AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
CREB-Binding ProteinCyclic AMP Response Element-Binding ProteinTrans-ActivatorsNuclear Proteinsp300-CBP Transcription FactorsHistone AcetyltransferasesE1A-Associated p300 ProteinRubinstein-Taybi SyndromeTranscription FactorsTranscriptional ActivationPromoter Regions, GeneticAcetyltransferasesAcetylationNuclear Receptor Coactivator 1Protein BindingDNA-Binding ProteinsBinding SitesTranscription, GeneticNuclear Receptor Coactivator 3Cell LineRecombinant Fusion ProteinsMolecular Sequence DataProtein Structure, TertiaryGene Expression RegulationTransfectionPhosphorylationSignal TransductionAmino Acid SequenceHistonesHeLa CellsPoly(A)-Binding ProteinsGenes, ReporterMutationActivating Transcription Factor 1Base SequenceGene Products, taxActivating Transcription FactorsTumor Cells, CulturedCarrier ProteinsCyclic AMP-Dependent Protein KinasesResponse ElementsHuman T-lymphotropic virus 1Tacrolimus Binding ProteinsRNA, MessengerPoly(A)-Binding Protein ICyclic AMPAdenovirus E1A ProteinsDNAInsulin-Like Growth Factor Binding ProteinsChromatin ImmunoprecipitationCell NucleusLuciferasesRepressor ProteinsRNA-Binding ProteinsCells, CulturedFatty Acid-Binding ProteinsBlotting, WesternPoly(A)-Binding Protein IIInsulin-Like Growth Factor Binding Protein 3Periplasmic Binding ProteinsCalcium-Binding ProteinsTacrolimus Binding Protein 1ALatent TGF-beta Binding ProteinsCell Line, TumorInsulin-Like Growth Factor Binding Protein 2
CREB-Binding Protein
A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.
Cyclic AMP Response Element-Binding Protein
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
Trans-Activators
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
p300-CBP Transcription Factors
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
Histone Acetyltransferases
Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones.
E1A-Associated p300 Protein
A member of the p300-CBP transcription factors that was originally identified as a binding partner for ADENOVIRUS E1A PROTEINS.
Rubinstein-Taybi Syndrome
A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Transcriptional Activation
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Acetyltransferases
Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.
Acetylation
Formation of an acetyl derivative. (Stedman, 25th ed)
Nuclear Receptor Coactivator 1
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in the transcriptional activation of chromatin regions.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Nuclear Receptor Coactivator 3
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Recombinant Fusion Proteins
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Phosphorylation
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Histones
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Poly(A)-Binding Proteins
Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.
Genes, Reporter
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Activating Transcription Factor 1
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Gene Products, tax
Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.
Activating Transcription Factors
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Cyclic AMP-Dependent Protein Kinases
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
Response Elements
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
Human T-lymphotropic virus 1
A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).
Tacrolimus Binding Proteins
A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Poly(A)-Binding Protein I
A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.
Cyclic AMP
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Adenovirus E1A Proteins
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Insulin-Like Growth Factor Binding Proteins
A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)
Chromatin Immunoprecipitation
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Luciferases
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
Repressor Proteins
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
RNA-Binding Proteins
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Fatty Acid-Binding Proteins
Intracellular proteins that reversibly bind hydrophobic ligands including: saturated and unsaturated FATTY ACIDS; EICOSANOIDS; and RETINOIDS. They are considered a highly conserved and ubiquitously expressed family of proteins that may play a role in the metabolism of LIPIDS.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Poly(A)-Binding Protein II
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Insulin-Like Growth Factor Binding Protein 3
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
Periplasmic Binding Proteins
Periplasmic proteins that scavenge or sense diverse nutrients. In the bacterial environment they usually couple to transporters or chemotaxis receptors on the inner bacterial membrane.
Calcium-Binding Proteins
Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.
Tacrolimus Binding Protein 1A
A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.
Latent TGF-beta Binding Proteins
A family of secreted multidomain proteins that were originally identified by their association with the latent form of TRANSFORMING GROWTH FACTORS. They interact with a variety of EXTRACELLULAR MATRIX PROTEINS and may play a role in the regulation of TGB-beta bioavailability.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Insulin-Like Growth Factor Binding Protein 2
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

The amino-terminal C/H1 domain of CREB binding protein mediates zta transcriptional activation of latent Epstein-Barr virus. (1/1067)

Latent Epstein-Barr virus (EBV) is maintained as a nucleosome-covered episome that can be transcriptionally activated by overexpression of the viral immediate-early protein, Zta. We show here that reactivation of latent EBV by Zta can be significantly enhanced by coexpression of the cellular coactivators CREB binding protein (CBP) and p300. A stable complex containing both Zta and CBP could be isolated from lytically stimulated, but not latently infected RAJI nuclear extracts. Zta-mediated viral reactivation and transcriptional activation were both significantly inhibited by coexpression of the E1A 12S protein but not by an N-terminal deletion mutation of E1A (E1ADelta2-36), which fails to bind CBP. Zta bound directly to two related cysteine- and histidine-rich domains of CBP, referred to as C/H1 and C/H3. These domains both interacted specifically with the transcriptional activation domain of Zta in an electrophoretic mobility shift assay. Interestingly, we found that the C/H3 domain was a potent dominant negative inhibitor of Zta transcriptional activation function. In contrast, an amino-terminal fragment containing the C/H1 domain was sufficient for coactivation of Zta transcription and viral reactivation function. Thus, CBP can stimulate the transcription of latent EBV in a histone acetyltransferase-independent manner mediated by the CBP amino-terminal C/H1-containing domain. We propose that CBP may regulate aspects of EBV latency and reactivation by integrating cellular signals mediated by competitive interactions between C/H1, C/H3, and the Zta activation domain.  (+info)

The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. (2/1067)

Transcription factors of the interferon regulatory factor (IRF) family bind to the type I interferon (IFN)-responsive element (ISRE) and activate transcription from IFN-inducible genes. To identify cofactors that associate with IRF proteins, DNA affinity binding assays were performed with nuclear extracts prepared from tissue culture cells. The results demonstrated that the endogenous IRFs bound to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE complexes. By testing recombinant proteins, we show that PCAF directly binds to some but not all members of the IRF family through distinct domains of the two proteins. This interaction was functionally significant, since transfection of PCAF strongly enhanced IRF-1- and IRF-2-dependent promoter activities. Further studies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorbol ester treatment, which led to increased recruitment of PCAF to the IRF-ISRE complexes. Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-stimulated gene expression in U937 cells. Supporting the role for PCAF in conferring IFN responsiveness, transfection of PCAF into U937 cells led to a large increase in IFN-alpha-inducible promoter activity. These results demonstrate that PCAF is a phorbol ester-inducible coactivator of the IRF proteins which contributes to the establishment of type I IFN responsiveness.  (+info)

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP. (3/1067)

Association with the cellular coactivators p300 and CBP is required for the growth-regulatory function of adenoviral (Ad) early region 1A (E1A) proteins. E1A regions necessary for these interactions overlap with domains involved in the induction of tumours in immunocompetent rodents through highly oncogenic Ad12. Differences in the association of cellular factors with the respective E1A domains of Ad12 and nononcogenic Ad2 might therefore be involved in serotype-specific oncogenicity. We analyzed the interaction of the Ad12 E1A 235R protein with p300 and CBP. Here we demonstrate that in the case of Ad12, but not Ad2/5, amino acids (aa) 1-29 of E1A proteins are sufficient to bind the p300-C/H3 domain in vivo and wild-type p300 in vitro. The conserved arginine-2, which is essential for the interaction between Ad2 E1A and p300, was dispensable for the Ad12 E1A 235R-p300 interaction in vitro. In addition to the p300-C/H3 region, we identified a second domain within p300 (aa 1999-2200) binding to the 235R protein. Contrary to p300, the amino-terminus and CR1 are necessary to associate with CBP. The aa 1-29 of the 235R protein but not CR1 are essential for the repression of colTRE-driven gene expression. This repression function is strictly dependent on p300 but not on CBP.  (+info)

Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. (4/1067)

Yeast two-hybrid system was employed to isolate novel proteins that physically interact with PU.1, a member of Ets family transcription factors. Sequence analyses of several isolated clones positive for beta-galactosidase activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP). GST binding assay showed that the interacting sites were located at the transcriptional activation domain of PU.1 through 74-122 and the region spanning residues 1283-1915 of CBP. CBP potentiated PU.1-mediated transcription of the reporter gene driven by the multimerized PU.1-binding sites, suggesting that CBP functions as a coactivator for PU.1. Considering that CBP is a limited cellular component to function as a coactivator for several transcription factors, CBP may mediate synergistic and antagonistic interactions between PU.1 and other transcription factors during the process of hematopoietic cell differentiation.  (+info)

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation. (5/1067)

Calcium is the principal second messenger in the control of gene expression by electrical activity in neurons. Recruitment of the coactivator CREB-binding protein, CBP, by the prototypical calcium-responsive transcription factor, CREB and stimulation of CBP activity by nuclear calcium signals is one mechanism through which calcium influx into excitable cells activates gene expression. Here we show that another CBP-interacting transcription factor, c-Jun, can mediate transcriptional activation upon activation of L-type voltage-gated calcium channels. Calcium-activated transcription mediated by c-Jun functions in the absence of stimulation of the c-Jun N-terminal protein kinase (JNK/SAPK1) signalling pathway and does not require c-Jun amino acid residues Ser63 and Ser73, the two major phosphorylation sites that regulate c-Jun activity in response to stress signals. Similar to CREB-mediated transcription, activation of c-Jun-mediated transcription by calcium signals requires calcium/ calmodulin-dependent protein kinases and is dependent on CBP function. These results identify c-Jun as a calcium-regulated transcriptional activator and suggest that control of coactivator function (i.e. recruitment of CBP and stimulation of CBP activity) is a general mechanism for gene regulation by calcium signals.  (+info)

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. (6/1067)

Disaggregation of the spherical nuclear bodies termed promyelocytic (PML) oncogenic domains (PODs) is a characteristic of acute promyelocytic leukemia. Here, we demonstrate that the cAMP enhancer binding protein (CREB)-binding protein (CBP) associates with PML in vitro and is recruited to the PODs in vivo. Through its association with CBP, wild-type PML dramatically stimulates nuclear receptor transcriptional activity. These results demonstrate that a fraction of CBP is compartmentalized to the POD through its association with PML and thus suggest that PML and other POD-associated proteins may play an unexpectedly broad role in aspects of transcriptional regulation and human disease.  (+info)

CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. (7/1067)

Nuclear factor I (NFI) binds to a region of the phosphoenolpyruvate carboxykinase (GTP) (PEPCK) gene promoter adjacent to the cAMP regulatory element (CRE) and inhibits the induction of transcription from the gene promoter caused by the catalytic subunit of protein kinase A. In vivo footprinting studies demonstrated that both the CRE and the NFI-binding site are occupied by transcription factors, regardless of the presence of factors that stimulate (dibutyryl cAMP or dexamethasone) or inhibit (insulin) transcription from the PEPCK gene promoter. The NFI effects on transcription from the PEPCK gene promoter were observed even in the absence of the NFI binding site, suggesting the possibility of other weaker binding sites on the promoter or an interaction of NFI with a transcriptional co-activator. A mammalian two-hybrid system was used to demonstrate direct interaction between the transactivation domain of NFI-C and the CREB binding domain of the CREB-binding protein (CBP). Overexpression of a gene fragment encoding the CREB binding domain of CBP stimulates transcription from the PEPCK gene promoter. The inhibitory effect of NFI on transcription of the PEPCK gene induced by the catalytic subunit of protein kinase A appears to be the result of an interaction between NFI and the CREB-binding protein in which NFI competes with CREB for binding to the CREB-binding site on CBP. In contrast, glucocorticoids and thyroid hormone use the steroid hormone receptor binding domain of CBP to stimulate transcription from the PEPCK gene promoter. NFI-A combines with dexamethasone or thyroid hormone in an additive manner to stimulate PEPCK gene transcription. We conclude that CBP coordinates the action of the multiple factors known to control transcription of the PEPCK gene.  (+info)

CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. (8/1067)

Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched transcription factor that is crucial in the regulation of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism and in determining the hepatic phenotype. We have previously shown that HNF-4 contains transcription activation functions at the N terminus (AF-1) and the C terminus (AF-2) which work synergistically to confer full HNF-4 activity. Here, we show that HNF-4 recruits the CREB-binding protein (CBP) coactivator on promoters of genes that contain functional HNF-4 sites. HNF-4 interacts with the N-terminal region of CBP (amino acids 1-771) and the C-terminal region of CBP (amino acids 1812-2441). The two activating functions of HNF-4, AF-1 and AF-2, interact with the N terminus and the N and C terminus of CBP, respectively. In addition, we show that in contrast to the other nuclear hormone receptors the interaction between HNF-4 and CBP is ligand-independent. Recruitment of CBP by HNF-4 results in an enhancement of the transcriptional activity of the latter. CBP does not activate gene expression in the absence of HNF-4, and dominant negative forms of HNF-4 prevent transcriptional activation by CBP, suggesting that the mere recruitment of CBP by HNF-4 is not sufficient for enhancement of gene expression. These findings demonstrate that CBP acts as a transcriptional coactivator for HNF-4 and provide new insights into the regulatory function of HNF-4.  (+info)

C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/p300<...
TY - JOUR. T1 - C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/p300. AU - Wang, Haitao. AU - Larris, Brian. AU - Peiris, T. Harshani. AU - Zhang, Liping. AU - Le Lay, John. AU - Gao, Yan. AU - Greenbaum, Linda E.. PY - 2007/8/24. Y1 - 2007/8/24. N2 - The E2F transcription factors play an essential role in regulating the G1- to S-phase transition of the cell cycle. Previous studies have identified the importance of interactions between E2Fs and other transcription factors as a mechanism for transcriptional control of a subset of E2F regulated target genes. However, the mechanisms responsible for E2F target gene specificity remain incompletely understood. Here we report that in a mammalian in vivo model of synchronized proliferation, C/EBPβ occupancy on the promoters of E2F-regulated growth-related genes increases as a function of cell cycle progression. C/EPBβ binding to these promoters is associated with recruitment of the coactivator ...
https://mayoclinic.pure.elsevier.com/en/publications/cebp%CE%B2-activates-e2f-regulated-genes-in-vivo-via-recruitment-of-th
2rny - Proteopedia, life in 3D2rny - Proteopedia, life in 3D
Histone lysine acetylation is central to epigenetic control of gene transcription. Bromodomains of chromosomal proteins function as acetyl-lysine (Kac) binding domains. However, how bromodomains recognize site-specific histones remains unanswered. Here, we report three three-dimensional solution structures of the bromodomains of the human transcriptional coactivators CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) bound to peptides derived from histone acetylation sites at lysines 36 and 9 in H3, and lysine 20 in H4. From structural and biochemical binding analyses, we determine consensus histone recognition by the bromodomains of PCAF and CBP, which represent two different subgroups of the bromodomain family. Through bromodomain residues in the ZA and BC loops, PCAF prefers acetylation sites with a hydrophobic residue at (Kac+2) position and a positively charged or aromatic residue at (Kac+3), whereas CBP favors bulky hydrophobic residues at (Kac+1) and (Kac+2), a positively ...
http://proteopedia.org/wiki/index.php/2rny
Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family,...
Members of the CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) family bind CREB-binding protein and p300 with high affinity and regulate gene transcription. Gene knockout studies indicate that CITED2 is required for neural crest and neural tube development and that it functions as a co-activator for transcription factor AP-2 (TFAP2). Here we describe human CITED4, a new member of this family, which is encoded by a single exon mapping to chromosome 1p34--1p35. CITED4 and p300/CREB-binding protein are present in endogenous naturally occurring complexes, indicating that they interact physiologically. The interaction occurs between the cysteine-histidine-rich domain 1 of p300 and the carboxyl terminus of CITED4. In keeping with this, CITED4 functions as a transactivator when artificially targeted to a promoter element. CITED4 physically interacts with all TFAP2 isoforms in vitro and strongly co-activates all TFAP2 isoforms in Hep3B cells. Co-activation of TFAP2 requires amino
https://www.cardioscience.ox.ac.uk/publications/110442
The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein |...The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein |...
Mier1 encodes a novel transcriptional regulator and was originally isolated as a fibroblast growth factor early response gene. Two major protein isoforms have been identified, MIER1α and β, which differ in their C-terminal sequence. Previously, we demonstrated that both isoforms recruit histone deacetylase 1 (HDAC1) to repress transcription. To further explore the role of MIER1 in chromatin remodeling, we investigated the functional interaction of MIER1 with the histone acetyltransferase (HAT), Creb-binding protein (CBP). Using GST pull-down assays, we demonstrate that MIER1 interacts with CBP and that this interaction involves the N-terminal half (amino acids 1-283) of MIER1, which includes the acidic activation and ELM2 domains and the C-terminal half (amino acids 1094-2441) of CBP, which includes the bromo-, HAT, C/H3 and glutamine-rich domains. Functional analysis, using HEK293 cells, shows that the CBP bound to MIER1 in vivo has no detectable HAT activity. Histone 4 peptide binding assays
https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-1-68
Arbeiten aus dem pathologischen institut 1999
Avots, A., Buttmann, M., Chupvilo, S., Escher, C., Smola, U., Bannister, A.J., Rapp, U.R., Kouzarides, T., Serfling, E. CBP/p300 integrates Raf/Rac-signalling pathways in the transcriptional induction of NF-Atc during T cell activation Immunity 10: 515-524 (1999) Chirmule, N., Avots, A., LakshmiTamma, S.M., Pahwa, S., Serfling, E. CD4-mediated signals induce T cell dysfunction in vivo J. Immunol. 163: 644-649 (1999) Bannert, N., Avots, A., Baier, M., Serfling, E., Kurth, R. GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes Proc. Natl. Acad. Sci. USA 96: 1541-1546 (1999) Chupvilo, S., Zimmer, M., Kerstan, A., Glöckner, J., Avots, A., Escher, C., Fischer, C., Inashkina, I., Jankevics, E., Berberich-Siebelt, F., Schmitt, E., Serfling, E. Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells Immunity 10: 261-269 (1999) Chupvilo, S., Avots, A., ...
http://pdfpills.com/p/pathologie.uni-wuerzburg.de1.html
Correction to: Multiple functions of CREB-binding protein during postembryonic development: identification of target genes |...Correction to: Multiple functions of CREB-binding protein during postembryonic development: identification of target genes |...
Following the publication of this article [1], the authors found that the primers listed for CREB-binding protein were not correct. This mistake occurred during assembly of the primer table and the authors apologize for this error. This correction does not change the data included in the paper, their interpretation nor the conclusions drawn.
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4939-8
Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha...Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha...
In the present study, we sought to examine the molecular basis for the differential regulation of several members of the IFN-α/β gene family (IFNA and IFNB) by IRF-3 and IRF-7. The IFNB, IFNA1, IFNA2, and RANTES promoters were activated by coexpression of either IRF-3 or IRF-7, whereas the IFNA4, IFNA7, and IFNA14 promoters were exclusively activated by IRF-7 and not by IRF-3. Analysis of protein-DNA interactions revealed that recombinant IRF-3 and IRF-7 selectively bound to different regions of the IFNB promoter; IRF-3 bound preferentially to the PRDIII domain of the IFNB promoter, while IRF-7 interacted exclusively with the PRDI domain. PCR-mediated DNA binding site selection results demonstrated that IRF-3 recognized the IRF consensus element 5′-GAAANNGAAANN-3′. Replacement of a single nucleotide within the GAAA core half-site was sufficient to preclude IRF-3 DNA binding. IRF-7 bound to a related sequence motif but with greater flexibility than IRF-3; a single nucleotide replacement did ...
https://mcb.asm.org/content/20/17/6342?ijkey=0ed32a5df8be9c37b47e08ea630dc54ce72296fd&keytype2=tf_ipsecsha
Plus itPlus it
The major finding in this study is that ethanol induces an increase in gene expression via CREB and PKA. This increase in gene expression requires both PKA and CREB phosphorylation. Although we had previously shown that exposure to ethanol resulted in phosphorylation of CREB in NG108-15 cells, there is accumulating evidence that CREB phosphorylation is not sufficient to regulate gene expression under the control of CREs; activation of the coactivator CREB-binding protein (CBP) and other downstream elements is also required for increases in CRE-mediated gene expression (Montminy, 1997; Cardinaux et al., 2000).Thibault et al. (2000) have reported increases in genes the expression of which is known to be cAMP-dependent. However, ethanol activates many different signal transduction pathways in addition to PKA (Diamond and Gordon, 1997), and most genes have regulatory elements activated or inhibited by all of these pathways. Therefore, the experiments presented here are the first demonstration that ...
http://jpet.aspetjournals.org/content/301/1/66
CREB-binding protein (Q92793) | InterPro | EMBL-EBICREB-binding protein (Q92793) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/protein/Q92793
Peter Tompa LabPeter Tompa Lab
We also aim to understand the structure-function relationship of very large (oversized) proteins, practically neglected from a structural point of view thus far. Structural biology has traditionally addressed the structure of small folded proteins, whereas the field of structural disorder has focused on either fully disordered proteins/regions or short disordered elements that undergo induced folding in the presence of their partner. Here we would like to probe into the structure of the very large transcriptional co-activator CREB-binding protein (CBP), by addressing its structure by means traditionally applied in the case of protein complexes. CBP has about seven domains and disordered linker regions connecting them, the topology of which will be outlined by a combination of high-resolution (NMR, X-ray) and low-resolution (MS, EM, AFM) techniques ...
http://www.vib.be/en/research/scientists/Pages/Peter-Tompa-Lab.aspx
JoVE Author Search: Altura RA
Cancer, Epidermal Growth Factor, Gene, Growth, Survival, Cell Line, Tumors, Disease, Kinase, Mutation, Patient, Phenotype, Cell, Insulin, Mouse, Acetylation, Binding Protein, Creb-binding Protein, Neuroblastoma, Nuclear Export
http://labindex.jove.com/author/Altura-RA
RegPhos
Function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase ...
http://regphos.mbc.nctu.edu.tw/browse_kinase_substrate.php?group=CMGC&family=CDK&subfamily=CDC2&kinase=CDK2&substrate=KHDRBS1&ID=KHDR1_HUMAN
Want to stop ageing and look younger, go dieting.Want to stop ageing and look younger, go dieting.
It does not matter how the diet is restricted. It can be in terms of carbohydrates,fats or proetins. What matters is the diet should be of low calorie. This brings about a change in the CBP proteins that control the genes related to cellular functions ...
http://world4u-world4u.blogspot.com/2009/11/want-to-stop-ageing-and-look-younger-go.html
JCI - Obstructive sleep apnea and insight into mechanisms of sympathetic overactivityJCI - Obstructive sleep apnea and insight into mechanisms of sympathetic overactivity
The inappropriate sustained SNA increase in OSA patients likely contributes to hypertension, organ damage, and mortality; however, it is unclear how excessive SNA develops in these patients. Several factors, including obesity and increased carotid body chemoreceptor sensitivity due to intermittent hypoxia, have been considered. Obesity could mechanically obstruct the airway and increase SNA through leptin, insulin, angiotensin, and cytokine actions; however, many OSA patients are not obese (23). Carotid body hypersensitivity as a result of intermittent hypoxia has been confirmed in animal models of OSA. In fact, plasticity of the carotid body glomus cells with long-term sensory facilitation and sensitization have been reported (18, 24) and associated with ROS and NOX2-dependent accumulation of HIF1 and the transcriptional coactivator CREB-binding protein (25). Central neuroplasticity. A provocative possibility for OSA-associated SNA dysfunction is that excessive activation of CNS nuclei induces ...
https://www.jci.org/articles/view/70420
Sabinet | Rubinstein-Taybi syndrome : dental manifestations and management : case reportSabinet | Rubinstein-Taybi syndrome : dental manifestations and management : case report
Rubinstein-Taybi syndrome (RSTS) is an uncommon genetic disorder characterised by a typical facies, small stature, broad angulated thumbs and intellectual impairment. Dental changes are a minor, yet significant component of the condition. Craniofacial growth retardation in RSTS is frequently complicated by unerupted teeth, while dental caries is related to the inherent intellectual deficit. Dental problems necessitate interdisciplinary management in terms of oral surgery, conservative dentistry, periodontics and orthodontics. When affected individuals are unco-operative, certain dental procedures may warrant general anaesthesia. In these instances, dental and medical staff will combine their expertise to enhance the well-being of the patient. In addition, specific dental changes may alert the medical practitioner to the possible diagnosis of RSTS. In this article we document the oro-dental manifestations and review the oro-dental approach in the management of three patients with RSTS. Our experience in
http://journals.co.za/content/m_sajch/8/1/EJC150063
Rubinstein - Taybi Syndrome (Rubinstein syndrome, broad thumb-hallux syndrome, broad thumbs and great toes, characteristic...Rubinstein - Taybi Syndrome (Rubinstein syndrome, broad thumb-hallux syndrome, broad thumbs and great toes, characteristic...
Rubinstein, J. Broad thumb-hallux (Rubinstein-Taybi) Syndrome 1957-1988. Am J Med Gen Suppl . vol. 6. 1990. pp. 3-16. (An early review of 571 cases, this article provides a detailed description of the physical findings in this syndrome.). Wiley, S, Swayne, S, Rubinstein, J, Lanphear, N, Stevens, C. Rubinstein-Taybi syndrome medical guidelines. Am J Med Genet. vol. 119A. 2003. pp. 101-110. (This article includes specific surveillance and intervention recommendations compiled by a group of pediatric experts.). Cantani, A, Gagliesi, D. Rubinstein-Taybi syndrome. Review of 732 cases and analysis of typical traits. Eur Rev Med Pharmacol Sci. vol. 2. 1998. pp. 81-87. (This is an analysis of 732 cases and provides a summary of the physical findings of the syndrome and discusses epidemiology and genetics known at the time of publication.). Roelfsema, J, Peters, D. Rubinstein-Taybi syndrome: clinical and molecular overview. Expert Rev Mol Med. vol. 9. 2007. pp. 1-15. (This article details the ...
https://www.oncologynurseadvisor.com/home/decision-support-in-medicine/dermatology/rubinstein-taybi-syndrome-rubinstein-syndrome-broad-thumb-hallux-syndrome-broad-thumbs-and-great-toes-characteristic-facies-and-mental-retardation/
EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74...EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74...
EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74 patients.
https://scholars.duke.edu/display/pub1462445
JCI - Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or...JCI - Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or...
Mutations in the coactivator CREB-binding protein (CBP) are a major cause of the human skeletal dysplasia Rubinstein-Taybi syndrome (RTS); however, the mechanism by which these mutations affect skeletal mineralization and patterning is unknown. Here, we report the identification of 3-phosphoinositide-dependent kinase 1 (PDK1) as a key regulator of CBP activity and demonstrate that its functions map to both osteoprogenitor cells and mature osteoblasts. In osteoblasts, PDK1 activated the CREB/CBP complex, which in turn controlled runt-related transcription factor 2 (RUNX2) activation and expression of bone morphogenetic protein 2 (BMP2). These pathways also operated in vivo, as evidenced by recapitulation of RTS spectrum phenotypes with osteoblast-specific Pdk1 deletion in mice (Pdk1osx mice) and by the genetic interactions observed in mice heterozygous for both osteoblast-specific Pdk1 deletion and either Runx2 or Creb deletion. Finally, treatment of Pdk1osx and Cbp+/- embryos with BMPs in utero ...
https://www.jci.org/articles/view/59466/figure/1
CREBBP CREB binding protein [Homo sapiens (human)] - Gene - NCBICREBBP CREB binding protein [Homo sapiens (human)] - Gene - NCBI
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in ...
https://www.ncbi.nlm.nih.gov/gene/?term=1387
CREBBP | SelfDecode | Genome AnalysisCREBBP | SelfDecode | Genome Analysis
hypothetical protein, A306_06942, Anapl_13162, AS27_07110, CBP, CBP/p300, CREB-binding protein, CREB binding protein (Rubinstein-Taybi syndrome), crebbp-a, crebbp-b, D623_10028045, E1A binding protein p300, EP300, H920_13788, hmm291030, KAT3A, M91_18874, MDA_GLEAN10009599, N301_13283, N302_12939, N303_04372, N307_13277, N308_10632, N309_02966, N311_11763, N312_01973, N321_00697, N326_12400, N327_01513, N332_08465, N334_05471, N335_14336, N336_02992, N339_02947, p300, p300/CBP, PAL_GLEAN10011621, RSTS, RTS, UY3_13419, Y1Q_016907, Z169_09090, crebbp ...
https://www.selfdecode.com/gene/crebbp/
Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15<...
TY - JOUR. T1 - Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666 - 15. AU - Xie, Fuchun. AU - Fan, Qiuhua. AU - Li, Bingbing X.. AU - Xiao, Xiangshu. PY - 2019/1/1. Y1 - 2019/1/1. N2 - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, we designed an ester prodrug of 666-15 through a long-range O,N-acyl transfer reaction for improved aqueous solubility. Unexpectedly, we discovered a small molecule 11 (653-47) that can potentiate the CREB inhibitory activity of 666-15 although 653-47 alone does not inhibit CREB.. AB - CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor. Herein, ...
https://ohsu.pure.elsevier.com/en/publications/discovery-of-a-synergistic-inhibitor-of-camp-response-element-bin
What does p/ CIP mean? - Definition of p/ CIP - p/ CIP stands for p300/ CREB-binding protein (CBP)-interacting protein. By...What does p/ CIP mean? - Definition of p/ CIP - p/ CIP stands for p300/ CREB-binding protein (CBP)-interacting protein. By...
Hop on to get the meaning of p/ CIP acronym / slang / Abbreviation. The Medical & Science Acronym / Slang p/ CIP means... AcronymsAndSlang. The p/ CIP acronym/abbreviation definition. The p/ CIP meaning is p300/ CREB-binding protein (CBP)-interacting protein. The definition of p/ CIP by AcronymAndSlang.com
http://acronymsandslang.com/definition/3337905/p%2F-CIP-meaning.html
Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene...
TY - JOUR. T1 - Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene promoter.. AU - Illi, B.. AU - Puri, P.. AU - Morgante, L.. AU - Capogrossi, M. C.. AU - Gaetano, C.. PY - 2000/6/23. Y1 - 2000/6/23. N2 - -The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding protein (CREB) and nuclear factor-kappaB (NF-kappaB)-related antigens bind specific sequences in the Flk-1/KDR promoter. Functional studies demonstrate that cAMP represses whereas tumor necrosis factor-alpha, an activator of NF-kappaB, stimulates promoter activity. Histone acetyltransferases (HATs) P/CAF and CBP/p300 together with p65/RelA, the catalytic subunit of NF-kappaB, increase Flk-1/KDR promoter ...
https://moh-it.pure.elsevier.com/en/publications/nuclear-factor-kappab-and-camp-response-element-binding-protein-m
Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.
CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma. Through transcriptional and epigenetic profiling of these B cells, we found that Crebbp inactivation was associated with broad transcriptional alterations, but no changes in the patterns of histone acetylation at the proximal regulatory regions of these genes. However, B cells with Crebbp inactivation showed high expression of Myc and patterns of altered histone acetylation that were localized to intragenic regions, enriched for Myc DNA binding motifs, and showed Myc binding. Through the analysis of CREBBP mutations from a large cohort of primary human FL and DLBCL, we show a significant difference in the spectrum of CREBBP mutations in these 2 diseases, with higher frequencies of ...
https://www.sebbm.es/web/en/science-for-society/article-of-the-month/2237-crebbp-loss-cooperates-with-bcl2-overexpression-to-promote-lymphoma-in-mice
Gene | CREBBPGene | CREBBP
The CREBBP gene is associated with autosomal dominant Rubinstein-Taybi syndrome 1 (RSTS1) (MedGen UID: 48517) and is commonly deleted in the recurrent 16p13.3 microdeletion syndrome (OMIM: 610543), a severe form of RSTS resulting from a contiguous gene deletion involving CREBBP as well as other neighboring genes.
https://www.invitae.com/en/physician/genes/20705/
Genetics of Rubinstein-Taybi Syndrome Follow-up: Further Outpatient Care, Complications, PrognosisGenetics of Rubinstein-Taybi Syndrome Follow-up: Further Outpatient Care, Complications, Prognosis
In 1963, Rubinstein and Taybi first described a malformation syndrome characterized by distinctive facies, mental retardation, broad thumbs, and broad great toes as are seen in the images below. {file44122}{file44123}{file44124}Deletions in band 16p13 have been described in association with this disorder, and mutations in the cyclic adenosin...
https://emedicine.medscape.com/article/948453-followup
OriGene - CREBBP (NM 004380) Human ORF cDNA CloneOriGene - CREBBP (NM 004380) Human ORF cDNA Clone
CREBBP - CREBBP (Myc-DDK-tagged)-Human CREB binding protein (CREBBP), transcript variant 1 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_004380/RC219036/CREBBP.aspx
The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction. | Sigma-AldrichThe LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Q Li, H Peng, H Fan, X Zou, Q Liu, Y Zhang, H Xu, Y Chu, C Wang, K Ayyanathan, F J Rauscher, K Zhang, Z Hou].
https://www.sigmaaldrich.com/catalog/papers/26113042
Directly Modulating Glucose Homeostasis | Science SignalingDirectly Modulating Glucose Homeostasis | Science Signaling
The concentration of glucose in the bloodstream is regulated by glucose itself, along with the hormones insulin and glucagon. Glucagon stimulates gluconeogenesis in part by regulating phosphorylation of a transcriptional coactivator known as cyclic adenosine monophosphate response element-binding protein 2 (CRTC2). Dentin et al. (see the Perspective by Birnbaum) found that high concentrations of circulating glucose also regulate CRTC2, but do so through stimulation of the hexosamine biosynthetic pathway and consequent O-linked glycosylation of the same serine residue in CRTC2 that is modified by phosphorylation. Thus, CRTC2 integrates signals from hormones and nutrients and might be a target for efforts to treat abnormalities of glucose homeostasis that are associated with diabetes.. R. Dentin, S. Hedrick, J. Xie, J. Yates, III, M. Montminy, Hepatic glucose sensing via the CREB coactivator CRTC2. Science 319, 1402-1405 (2008). [Abstract] [Full Text]. M. J. Birnbaum, Sweet conundrum. Science 319, ...
http://stke.sciencemag.org/content/1/10/ec93
Thiopental Inhibits the Activation of Nuclear Factor κB | Anesthesiology | American Society of AnesthesiologistsThiopental Inhibits the Activation of Nuclear Factor κB | Anesthesiology | American Society of Anesthesiologists
Total cell extracts were prepared using a high-salt detergent buffer (20 mm Hepes, pH 7.9, 350 mm NaCl, 20%[vol/vol] glycerol, 1%[wt/vol] NP-40, 1 mm MgCl2, 0.5 mm EDTA, 0.1 mm EGTA, 0.5 mm dithiothreitol, 0.1% PMSF, 1% aprotinin). Cells were harvested by centrifugation, washed once in ice-cold phosphate-buffered saline, and resuspended in four cell volumes of the detergent buffer. The cell lysate was incubated for 30 min on ice and then centrifuged for 5 min at 13,000 g at 4°C. EMSAs were performed with 32P-labeled oligonucleotides of either the inducible NF-κB or the constitutively active cyclic adenosine monophosphate response element binding protein (CREB) as previously described. 20The reaction mixture consisted of 37 μl purified water, 1 μl NF-κB or CREB oligonucleotides (25 ng/μl; Promega, Madison, WI), 5 μl kinase buffer, 5 μl γ-32P-dATP (Amersham International, Braunschweig, Germany), and 1.5 μl T4 kinase (polynucleotide kinase [PNK] buffer and PNK T4 kinase; New England ...
https://pubs.asahq.org/anesthesiology/article/96/5/1202/40067/Thiopental-Inhibits-the-Activation-of-Nuclear?searchresult=1
CREBBP - CHDgene
Roelfsema, J. H., White, S. J., Ariyürek, Y., Bartholdi, D., Niedrist, D., Papadia, F., … Peters, D. J. M. (2005). Genetic Heterogeneity in Rubinstein-Taybi Syndrome: Mutations in Both the CBP and EP300 Genes Cause Disease. The American Journal of Human Genetics, 76(4), 572-580. DOI:10.1086/429130 PMID:15706485 ...
http://chdgene.victorchang.edu.au/gene/1387
Molecular Characterization of Propionyllysines in Non-histone Proteins | Molecular & Cellular ProteomicsMolecular Characterization of Propionyllysines in Non-histone Proteins | Molecular & Cellular Proteomics
Lysine propionylation and butyrylation are protein modifications that were recently identified in histones. The molecular components involved in the two protein modification pathways are unknown, hindering further functional studies. Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein. We used mass spectrometry to map lysine propionylation sites within these three proteins. We also identified the first two in vivo eukaryotic lysine propionyltransferases, p300 and CREB-binding protein, and the first eukaryotic depropionylase, Sirt1. p300 was able to perform autopropionylation on lysine residues in cells. Our results suggest that lysine propionylation, like lysine acetylation, is a dynamic and regulatory post-translational modification. Based on these observations, it appears that some enzymes are common to the lysine propionylation and lysine acetylation regulatory pathways. Our ...
https://www.mcponline.org/content/8/1/45.abstract
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta...
In type 2 diabetes, chronic hyperglycemia is detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element-binding protein (CREB) is crucial for beta-cell survival and function. We inves
http://www.biomedsearch.com/nih/Degradation-cAMP-responsive-element-binding/19223597.html
Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription<...Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription<...
TY - JOUR. T1 - Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription. AU - Xie, Fuchun. AU - Li, Bingbing X.. AU - Xiao, Xiangshu. N1 - Funding Information: This work was made possible through financial supports provided by the United States National Institutes of Health ( R01GM087305 ) and OHSU Office of Technology Transfer and Business Development . PY - 2017/2/1. Y1 - 2017/2/1. N2 - cAMP-response element binding protein (CREB) is a nuclear transcription factor that has been implicated in the pathogenesis and maintenance of various types of human cancers. Identification of small molecule inhibitors of CREB-mediated gene transcription has been pursued as a novel strategy for developing cancer therapeutics. We recently discovered a potent and cell-permeable CREB inhibitor called 666-15. 666-15 is a bisnaphthamide and has been shown to possess efficacious anti-breast cancer activity without toxicity in vivo. In this study, we ...
https://ohsu.pure.elsevier.com/en/publications/design-synthesis-and-biological-evaluation-of-regioisomers-of-666
Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB<...
TY - JOUR. T1 - Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. AU - Asahara, H.. AU - Santoso, B.. AU - Guzman, E.. AU - Du, K.. AU - Cole, P. A.. AU - Davidson, I.. AU - Montminy, M.. PY - 2001/11/22. Y1 - 2001/11/22. N2 - The cyclic AMP (cAMP)-responsive factor CREB induces target gene expression via constitutive (Q2) and inducible (KID, for kinase-inducible domain) activation domains that function synergistically in response to cellular signals. KID stimulates transcription via a phospho (Ser133)-dependent interaction with the coactivator paralogs CREB binding protein and p300, whereas Q2 recruits the TFIID complex via a direct association with hTAFII130. Here we investigate the mechanism underlying cooperativity between the Q2 domain and KID in CREB by in vitro transcription assay with naked DNA and chromatin templates containing the cAMP-responsive somatostatin promoter. The Q2 domain was highly active on a naked DNA template, and Ser133 ...
https://jhu.pure.elsevier.com/en/publications/chromatin-dependent-cooperativity-between-constitutive-and-induci-3
Plus itPlus it
Extensive evidence implicates CREB-dependent gene transcription in memory (Bourtchuladze et al., 1994; Yin et al., 1994; Guzowski and McGaugh, 1997; Bartsch et al., 1998; Kida et al., 2002; Pittenger et al., 2002; Frankland et al., 2004). Multiple signaling pathways phosphorylate CREB at Ser133 (Shaywitz and Greenberg, 1999; Mayr and Montminy, 2001; Lonze and Ginty, 2002), which stimulates the recruitment of coactivators CBP/p300 (Chrivia et al., 1993; Parker et al., 1996). However, this phosphorylation event is not always sufficient to activate transcription (Impey et al., 1996; Mayr and Montminy, 2001) suggesting that CREB-mediated transcription is regulated by additional mechanisms.. In 2003, two laboratories identified a new family of CREB-specific coactivators, now referred to as CRTCs (Iourgenko et al., 2003; Conkright et al., 2003b). CRTC is thought to enhance transcription by facilitating the interaction of CREB with the RNA polymerase II pre-initiation complex (Conkright et al., 2003b; ...
http://www.jneurosci.org/content/32/49/17857
Reassessing the folding of the KIX domain: evidence for a two-state mechanism. - RIIP - Réseau International des Instituts...Reassessing the folding of the KIX domain: evidence for a two-state mechanism. - RIIP - Réseau International des Instituts...
The debate about the presence and role of intermediates in the folding of proteins has been a critical issue, especially for fast folders. One of the classical methodologies to identify such metastable species is the burst-phase analysis, whereby the observed signal amplitude from stopped-flow traces is determined as a function of denaturant concentration. However, a complication may arise when folding is sufficiently fast to jeopardize the reliability of the stopped-flow technique. In this study, we reassessed the folding of the KIX domain from cAMP Response Element-Binding (CREB)-binding protein, which has been proposed to involve the formation of an intermediate that accumulates in the dead time of the stopped flow. By using an in-house-built capillary continuous flow with a 50-μs dead time, we demonstrate that this intermediate is not present; the problem arose because of the instrumental limitation of the standard stopped flow to assess very fast refolding rate constants (e.g., ≥ 500 s⁻¹).
https://hal-riip.archives-ouvertes.fr/pasteur-00960069
ERES MI HÉROE - Teaming GroupERES MI HÉROE - Teaming Group
ERES MI HÉROE. Eres mi Héroe es un grupo creado con la intención de ayudar a mejorar la calidad de vida de Iván (www.eresmiheroe.com). Iván nació con cataratas e hipotonía. Los médicos creen que tiene una enfermedad rara de origen genético llamada Síndrome de Rubinstein-Taybi. Iván tiene 18 dioptrías y un 72% de minusvalía. Entre otras cosas, Iván necesita recibir sesiones de fisioterapia y rehabilitación para ganar fuerza y movilidad. ¡Te necesitamos! ¿Nos ayudas?. Created on {2}.
https://www.teaming.net/eresmiheroe?lang=en_UK&page=1&f=1
New 2022 Jayco Eagle HT 28.5RSTS Fifth Wheel at Zoomers RV | Wabash, IN | #4907
Jayco Eagle HT fifth wheel 28.5RSTS highlights: Kitchen Island Dual Opposing Slides Tri-Fold Sofa Outside Kitchen LED Fireplace Auto-Leveling You will... #4907
https://www.zoomersrviowa.com/product/new-2022-jayco-eagle-ht-28-dot-5rsts-1557465-5
ALSU-PCREB-A-HV | PerkinElmerALSU-PCREB-A-HV | PerkinElmer
The AlphaLISA SureFire Ultra p-CREB (Ser133) assay kit (High Volume) is an immunoassay for quantitative detection of phospho-CREB in cellular lysates.
http://www.perkinelmer.com/product/alpha-sf-ultra-creb-ps133-hv-alsu-pcreb-a-hv
Cereal Eats: Kix | Serious EatsCereal Eats: Kix | Serious Eats
I remember the fateful day when I saw my first Kix Commercial with its slogan Kid Tested, Mother Approved. In my ten-year-old mind, Id finally found the loophole in the cruel system of parental cereal control. Somehow, my mom actually obeyed this mantra. Kix occasionally landed in our cabinets, a brightly colored beacon in a sea of white and brown boxes. Recently, I bought a box to see if they were still as great as I remembered.
http://www.seriouseats.com/2011/11/cereal-eats-kix.html
Long-term results following osteotomy of the thumb delta phalanx in Rubinstein-Taybi Syndrome. - The Kennedy Institute of...
Rubinstein-Taybi Syndrome is a rare condition affecting 1:125,000 children. It is associated with short broad radially deviated thumbs, secondary to a delta proximal phalanx of the thumb. We undertook a retrospective review of seven children (13 thumbs) with Rubinstein-Taybi syndrome whose thumbs were treated using a corrective osteotomy to the delta phalanx over a 13 year period. The types of osteotomy used in the series were reverse wedge osteotomy, opening wedge osteotomy and dome shaped osteotomy. The mean preoperative radial deviation of thumbs was 68 degrees (range 45-85 degrees ). At follow up five of the 13 thumbs demonstrated some residual radial deviation. All recurrences occurred in the dome shaped osteotomy group. Our data suggest that surgery is effective in correcting the deformity, but there is a risk of incomplete correction or recurrence. Despite the recurrence the mean postoperative deformity was significantly better than preoperatively and the majority of patients families
https://www.kennedy.ox.ac.uk/publications/244617
CAMP-responsive element-binding protein 3-like protein 4 | definition of cAMP-responsive element-binding protein 3-like protein...CAMP-responsive element-binding protein 3-like protein 4 | definition of cAMP-responsive element-binding protein 3-like protein...
Looking for online definition of cAMP-responsive element-binding protein 3-like protein 4 in the Medical Dictionary? cAMP-responsive element-binding protein 3-like protein 4 explanation free. What is cAMP-responsive element-binding protein 3-like protein 4? Meaning of cAMP-responsive element-binding protein 3-like protein 4 medical term. What does cAMP-responsive element-binding protein 3-like protein 4 mean?
http://medical-dictionary.thefreedictionary.com/cAMP-responsive+element-binding+protein+3-like+protein+4
CAMP-responsive element-binding protein 3-like protein 1 | definition of cAMP-responsive element-binding protein 3-like protein...CAMP-responsive element-binding protein 3-like protein 1 | definition of cAMP-responsive element-binding protein 3-like protein...
Looking for online definition of cAMP-responsive element-binding protein 3-like protein 1 in the Medical Dictionary? cAMP-responsive element-binding protein 3-like protein 1 explanation free. What is cAMP-responsive element-binding protein 3-like protein 1? Meaning of cAMP-responsive element-binding protein 3-like protein 1 medical term. What does cAMP-responsive element-binding protein 3-like protein 1 mean?
http://medical-dictionary.thefreedictionary.com/cAMP-responsive+element-binding+protein+3-like+protein+1
Rubinstein-Taybi Syndrome | Colorado PROFILES
A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3 ...
https://profiles.ucdenver.edu/display/214524
Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the...Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the...
Most reported microdeletions of the CREB-binding protein (CBP) gene in the Rubinstein-Taybi syndrome (RTS) were detected by fluorescence in situ hybridization (FISH) with a single cosmid probe specific to the 3 region of the gene. In order to test the hypothesis that the rate of microdeletion-posit …
https://pubmed.ncbi.nlm.nih.gov/10602114/?dopt=Abstract
Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...Identification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
https://www.hindawi.com/journals/bmri/2013/892491/
The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis<...
TY - JOUR. T1 - The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. AU - Ghosh, Asish K.. AU - Varga, John. PY - 2007/12/1. Y1 - 2007/12/1. N2 - The transcriptional coactivator p300 is a ubiquitous nuclear phosphoprotein and transcriptional cofactor with intrinsic acetyltransferase activity. p300 controls the expression of numerous genes in cell-type and signal-specific manner, and plays a pivotal role in cellular proliferation, apoptosis, and embryogenesis. By catalyzing acetylation of histones and transcription factors, p300 plays a significant role in epigenetic regulation. Recent evidence suggests that abnormal p300 function is associated with deregulated target gene expression, and is implicated in inflammation, cancer, cardiac hypertrophy, and genetic disorders such as the Rubinstein-Taybi syndrome. The activity of p300 is regulated at multiple levels, including developmental stage-specific expression, post-translational modifications, subcellular ...
https://www.scholars.northwestern.edu/en/publications/the-transcriptional-coactivator-and-acetyltransferase-p300-in-fib
4-PPBP - Wikipedia4-PPBP - Wikipedia
4-PPBP is a molecule which binds to sigma receptors.[1] 4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+dysregulation.[2]4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB. [3] ...
https://en.wikipedia.org/wiki/4-PPBP
Human Gene ATF4 (ENST00000337304.2) Description and Page IndexHuman Gene ATF4 (ENST00000337304.2) Description and Page Index
RefSeq Summary (NM_001675): This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011 ...
http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=ENST00000337304.2&hgg_prot=uc003aya.4&hgg_chrom=chr22&hgg_start=39520563&hgg_end=39522683&hgg_type=knownGene&db=hg38&hgsid=792032863_QAgkGU0ca3pjHwdSeLxJbUe0TjIP
Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide...Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide...
Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which increased cAMP-response element-binding protein (CREB) phosphorylation, was the predominant regulator of Pde3b expression. Real time PCR and immunoblotting indicated that in 3T3-L1 preadipocytes, IBMX-stimulated induction of Pde3b mRNA and protein was markedly inhibited by dominant-negative CREB proteins. By transfecting preadipocytes, differentiating preadipocytes, and HEK293A cells with luciferase reporter vectors containing different fragments of the 5- flanking region of the Pde3b gene, we identified a distal promoter that contained canonical cis-acting cAMP-response elements (CRE) and a proximal, GC-rich promoter region, which contained atypical CRE. Mutation of the CRE sequences dramatically reduced distal promoter activity; H89 inhibited IBMX-stimulated CREB phosphorylation and proximal and distal promoter activities. Distal promoter ...
https://www.ludc.lu.se/eva-degerman-pi/publication/22b14732-23a7-49da-acf7-b7dd55095f70
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease - Wang - 2005 - The EMBO Journal - Wiley...Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease - Wang - 2005 - The EMBO Journal - Wiley...
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional knockin strategy to bypass the embryonic lethality caused by MLL-CBP expression and to assess the immediate effects of induced MLL-CBP expression on hematopoiesis. Within days of activating MLL-CBP, the fusion protein selectively expanded granulocyte/macrophage progenitors (GMP) and enhanced their self-renewal/proliferation. MLL-CBP altered the gene expression program of GMP, upregulating a subset of genes including Hox a9. Inhibition of Hox a9 expression by RNA interference demonstrated that MLL-CBP required Hox a9 for its enhanced cell expansion. Following exposure to sublethal γ-irradiation or N-ethyl-N-nitrosourea (ENU), MLL-CBP mice developed myelomonocytic hyperplasia and progressed to fatal myeloproliferative disorders. These represented the spectrum of therapy-induced acute myelomonocytic ...
http://onlinelibrary.wiley.com/doi/10.1038/sj.emboj.7600521/abstract
Cardioprotection against experimental myocardial ischemic injury using corninCardioprotection against experimental myocardial ischemic injury using cornin
Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and r …
https://pubmed.ncbi.nlm.nih.gov/26871971/
Tissue expression of CREBBP - Staining in cervix, uterine - The Human Protein AtlasTissue expression of CREBBP - Staining in cervix, uterine - The Human Protein Atlas
Expression of CREBBP (CBP, KAT3A, RSTS, RTS) in cervix, uterine tissue. Antibody staining with HPA055861 and CAB004212 in immunohistochemistry.
http://www.proteinatlas.org/ENSG00000005339-CREBBP/tissue/cervix,+uterine
Plus itPlus it
The highly conserved, multifunctional Tudor-SN (also called SND1/p100) modulates gene expression by an assortment of processes in the nucleus and in the cytoplasm. The multifunctional properties of Tudor-SN can be attributed to its complex structure, consisting of multiple domains within the 4SN and Tsn modules (Gutierrez-Beltran et al., 2016). As a key component in RNA splicing, processing, and editing, the 4SN module has RNA-binding and RNA cleavage activities (Caudy et al., 2003; Scadden, 2005; Li et al., 2008). This modular region also exhibits unique protein recognition properties, as it interacts with several components of the basal transcription machinery, including ATP-dependent RNA helicase A (Välineva et al., 2006), Signal Transducer and Activator of Transcription6 (Yang et al., 2002), DNA-directed RNA polymerase II largest subunit, and CREB-binding protein (Välineva et al., 2005; Yang et al., 2007). A subsequent study also demonstrated that the SN-like domains bind to the 3′ UTR ...
http://www.plantphysiol.org/content/175/4/1608
Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy. | SBRCJust a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy. | SBRC
Here, we present a structural and dynamic description of CBP-ID4 at atomic resolution. ID4 is the fourth intrinsically disordered linker of CREB-binding protein (CBP). In spite of the largely disordered nature of CBP-ID4, NMR chemical shifts and relaxation measurements show a significant degree of α-helix sampling in the protein regions encompassing residues 2-25 and 101-128 (1852-1875 and 1951-1978 in full-length CBP). Proline residues are uniformly distributed along the polypeptide, except for the two α-helical regions, indicating that they play an active role in modulating the structural features of this CBP fragment. The two helical regions are lacking known functional motifs, suggesting that they represent thus-far uncharacterized functional modules of CBP. This work provides insights into the functions of this protein linker that may exploit its plasticity to modulate the relative orientations of neighboring folded domains of CBP and fine-tune its interactions with a multitude of ...
http://sbrc.vub.ac.be/node/1299
Plus itPlus it
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)-derived lymphomas in mice. In both human and murine lymphomas, CREBBP loss-of-function resulted in focal depletion of enhancer H3K27 acetylation and aberrant transcriptional silencing of genes that regulate B-cell signaling and immune responses, including class II MHC. Mechanistically, CREBBP-regulated enhancers are counter-regulated by the BCL6 transcriptional repressor in a complex with SMRT and HDAC3, which we found to bind extensively to MHC class II loci. HDAC3 loss-of-function rescued repression of these enhancers and corresponding genes, including MHC class II, and more profoundly suppressed CREBBP-mutant lymphomas in vitro and in vivo. Hence, CREBBP loss-of-function contributes to lymphomagenesis by enabling unopposed suppression of enhancers by BCL6/SMRT/HDAC3 complexes, suggesting HDAC3-targeted therapy as a precision approach for ...
http://cancerdiscovery.aacrjournals.org/content/early/2016/12/15/2159-8290.CD-16-0975
April | 2013 | dub inhibitors
LCLs from patients with various kinds of chromatin abnormalities were obtained: ICF problem, CLS, FSHD and RSTS. Two of the three RSTS products had confirmedmutations in CREB binding protein. Nuclear extracts from these LCLs were immunoblotted for ATM s1981. demonstrates that low irradiated LCLs fromICF people displayedmarkedly increased amounts Geneticin manufacturer of ATM s1981 that resembled irradiated normal cells. In contrast to the ICF LCLs, samples from two FSHD patients displayed low phosphorylation levels that resembled the non irradiated get a handle on samples N1 and N 3. An individual with CLS and samples from three RSTS people also exhibited low phosphorylation levels that were slightly greater than the get a handle on samples, an effect that was reproducible. LCLs from an ATM individual failed to show ATM s1981 despite IR, as previously reported. The strong ATM s1981 transmission in the ICF products caused us to further examine these LCLs. We first addressed whether ATM s1981 in ...
https://dubinhibitors.com/2013/04
DIGITAL.CSIC: Essential role of RelA Ser311 phosphorylation by PKC in NF-kB transcriptional activationDIGITAL.CSIC: Essential role of RelA Ser311 phosphorylation by PKC in NF-kB transcriptional activation
The activation of the transcription factor NF-kB is central to the control of the cellular response triggered by many stimuli. Once released from the inhibitory molecule IkB, NF-kB is translocated to the nucleus, and it has to be phosphorylated to activate transcription. In protein kinase C (PKC)-deficient cells, NF-kB is transcriptionally inactive and the phosphorylation of the RelA subunit in response to tumor necrosis factor (TNF-alpha) is severely impaired. In vitro assays showed that PKC directly phosphorylates RelA. Here we demonstrate that Ser311 accounts for PKC phosphorylation of RelA and that this site is phosphorylated in vivo in response to TNF-alpha. Also, an inactivating mutation of that residue severely impairs RelA transcriptional activity, blocks its anti-apoptotic function and abrogates the interaction of RelA with the co-activator CBP as well as its recruitment, and that of RNA polymerase II (Pol II) with the interleukin-6 (IL-6) promoter. The interaction of endogenous CBP ...
http://digital.csic.es/handle/10261/8238
Freds Dērsts - VikipēdijaFreds Dērsts - Vikipēdija
Freds Dērsts piedzima Džeksonvilā, Floridā, ASV. Fredu audzināja viņa māte Anita, jo viņa bioloģiskais tēvs aizgāja no ģimenes, kad Fredam bija tikai dažas nedēļas. Freds ar māti dzīvoja ļoti trūcīgi, viņiem nebija ne mājas, ne darba, ne naudas. Viņi dzīvoja baznīcas bēniņos, ēdot bērnu pārtiku, ko nesa draudzes locekļi. Kad Fredam bija divi gadi, Anita iepazinās ar policijas oficieri Bilu, ar kuru drīz vien viņa apprecējās.. Fredam jaunībā patika tā pati mūzika, kas viņa vecākiem, un viņš bieži ākstījās dejojot un iztēlojoties, ka uzstājas publikas priekšā. Kad Freds paaugās, viņš un viņa pusbrālis Korijs (Bila un Anitas dēls) kļuva par Kiss faniem.. Vēlāk Freda ģimene pārvācās no Džeksonvillas, Floridā, uz Gastoniju, Ziemeļkarolīnā, kur Dērsts mācījās Hunter Huss vidusskolā.[1] Šeit viņš sāk aizrauties ar hiphopu un izveido breika dejošanas grupu Reckless Crew. Viņš sāk interesēties par kultūru, kas ir ...
https://lv.wikipedia.org/wiki/Freds_D%C4%93rsts
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π InteractionA Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1002%252Fanie.201402750/reader
CREBBP - PrimePCR Assay and Template | Life Science | Bio-RadCREBBP - PrimePCR Assay and Template | Life Science | Bio-Rad
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
https://www.bio-rad.com/en-us/prime-pcr-assays/gene/crebbp-human
Sumava Rsts, IN
Demographics for Sumava Rsts, IN by Free US Zip Code Look Up, Zip Codes by City, County & State, Zip Code Map & Demographics, US Post Office Look Up, US and Canadian Zip Code Database.
https://www.zip-code-database.org/?Page=City&Id=40998&Country=us
Jaunumu raksts | Ārsts.lvJaunumu raksts | Ārsts.lv
Vislielāko vīrusu daudzumu inficētie pacienti izdala 2.-3. slimības dienā, t.i., šajā periodā viņi ir visinfekciozākie, tomēr nelielos, inficēšanai pietiekamos daudzumos vīrusa izdale var saglabāties līdz pat 1-2 nedēļām.. Attiecībā uz sabiedrībā valdošo uzskatu, ka gaisa recirkulācijas sistēmas, piemēram, lidmašīnās, paaugstina saaukstēšanās risku, ASV 2002. gadā veiktais pētījums šādu faktu nav apstiprinājis, tāpēc šobrīd jādomā, ka pārneses ceļam ar nemazgātām rokām ir vislielākā nozīme saaukstēšanās vīrusu izplatībā.. Nereti tiek diskutēts par to, cik bieži gada laikā slimot ar saaukstēšanos ir normāli. Vidēji pirmsskolas vecuma bērni slimo 6-8 (līdz pat 12) reizes gadā, katru reizi slimībai ilgstot aptuveni 14 dienas, savukārt vecāki bērni un pieaugušie vidēji slimo 2-4 reizes gadā, katru reizi simptomiem ilgstot 5-7 dienas.. Smēķētājiem gan simptomi parasti ilgst vairāk par nedēļu hroniska elpceļu ...
http://arsts.lv/jaunumi/angelika-krumina-saaukstesanas-slimibas-kas-jazina-katram
CREB-binding proteinCREB-binding protein
Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREB-binding protein), also known as CREBBP or ... Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques". The Protein Journal. 40 (1 ... Some of the proteins that bind to this domain have been shown to bind competitively-such as CREB and Myb-whereas others bind ... activates cAMP response element binding protein (CREB), which then binds to CBP as a coactivator for transcription of FOXO1. ...
https://en.wikipedia.org/wiki/CREB-binding_protein
RELARELA
Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (Apr 1997). "CREB-binding protein/p300 are transcriptional ... Aarnisalo P, Palvimo JJ, Jänne OA (Mar 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ... "Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with ... Parry GC, Mackman N (Dec 1997). "Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB- ...
https://en.wikipedia.org/wiki/RELA
P300-CBP coactivator familyP300-CBP coactivator family
... also called EP300 or E1A binding protein p300) CBP (also known as CREB-binding protein or CREBBP) Both p300 and CBP interact ... Vo N, Goodman RH (Apr 2001). "CREB-binding protein and p300 in transcriptional regulation". The Journal of Biological Chemistry ... "Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in ... "Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein". Mechanisms of Development. ...
https://en.wikipedia.org/wiki/P300-CBP_coactivator_family
In situ lymphoid neoplasiaIn situ lymphoid neoplasia
... encodes CREB-binding protein which contributes to the activation of various genes); 3) TNFSF14 (encodes tumor necrosis factor ... "CREBBP CREB binding protein [Homo sapiens (human)] - Gene - NCBI". "TNFSF14 TNF superfamily member 14 [Homo sapiens (human)] - ... In consequence, CCND1 overexpresses cyclin D1, a protein which promotes the cell cycle and thereby cellular proliferation. The ... a kinase that regulates the activity of various tumor suppressors and cell cycle proteins). It may also involve gains in the ...
https://en.wikipedia.org/wiki/In_situ_lymphoid_neoplasia
KIX domainKIX domain
"MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249- ... and mutability at the binding interface between the p160 coactivator and CREB-binding protein". Protein Science. 13 (1): 203-10 ... "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein ... It was thus first termed CREB-binding domain. However, when it was later discovered that it also binds many other proteins, the ...
https://en.wikipedia.org/wiki/KIX_domain
NFATC4NFATC4
... has been shown to interact with CREB-binding protein. NFAT ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ... NFATC4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. The product of ... Lahti AL, Manninen A, Saksela K (May 2003). "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct ...
https://en.wikipedia.org/wiki/NFATC4
PROX1PROX1
2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081-9. doi:10.1074/ ... Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation ... Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the ... PROX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural ...
https://en.wikipedia.org/wiki/PROX1
NFE2NFE2
Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)- ... Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated ... NFE2 has been shown to interact with CREB-binding protein. GRCh38: Ensembl release 89: ENSG00000123405 - Ensembl, May 2017 ... and NF-E2-binding proteins". J. Biol. Chem. 277 (44): 41563-70. doi:10.1074/jbc.M208184200. PMID 12196550. Marini MG, Asunis I ...
https://en.wikipedia.org/wiki/NFE2
MAF (gene)MAF (gene)
Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene ... Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene ... MAF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Vanita V, Singh D, Robinson PN, Sperling K, Singh JR (Mar 2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 ...
https://en.wikipedia.org/wiki/MAF_(gene)
SS18L1SS18L1
... has been shown to interact with CREB-binding protein. Biochemical pull down assays reveal SS18L1 to interact with ... SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene. Synovial sarcomas occur most frequently in the ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): ...
https://en.wikipedia.org/wiki/SS18L1
KLF4KLF4
... has been shown to interact with CREB-binding protein. It was found that the transcription factor Klf4 present at the ... are dependent on acidic amino acid residues and protein-protein interaction". Nucleic Acids Research. 28 (5): 1106-13. doi: ... are dependent on acidic amino acid residues and protein-protein interaction". Nucleic Acids Research. 28 (5): 1106-13. doi: ... are dependent on acidic amino acid residues and protein-protein interaction". Nucleic Acids Research. 28 (5): 1106-13. doi: ...
https://en.wikipedia.org/wiki/KLF4
Autoimmune regulatorAutoimmune regulator
The first AIRE partner that was identified is the CREB-binding protein (CBP) that is localized in nuclear bodies and is a co- ... Autoimmune regulator has been shown to interact with CREB binding protein. List of human clusters of differentiation for a list ... regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein ... regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein ...
https://en.wikipedia.org/wiki/Autoimmune_regulator
EBF1EBF1
... has been shown to interact with ZNF423 and CREB binding protein. GRCh38: Ensembl release 89: ENSG00000164330 - Ensembl, ... Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1. EBF1 ... Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 ... Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to ...
https://en.wikipedia.org/wiki/EBF1
GluconeogenesisGluconeogenesis
May 2009). "Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein". Cell. 137 ... Transport of PEP across the mitochondrial membrane is accomplished by dedicated transport proteins; however no such proteins ... it triggers phosphorylation of enzymes and regulatory proteins by Protein Kinase A (a cyclic AMP regulated kinase) resulting in ... In the liver, the FOX protein FOXO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks FOXO6 upon ...
https://en.wikipedia.org/wiki/Gluconeogenesis
PCAFPCAF
"Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein- ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ... Jin Y, Zeng SX, Dai MS, Yang XJ, Lu H (Aug 2002). "MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated ... The protein encoded by the PCAF gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, ...
https://en.wikipedia.org/wiki/PCAF
Sterol regulatory element-binding protein 2Sterol regulatory element-binding protein 2
SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. Sterol regulatory element-binding protein GRCh38: ... Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22 ... "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22 ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_2
HOXB7HOXB7
... has been shown to interact with PBX1 and CREB-binding protein. Homeobox GRCh38: Ensembl release 89: ENSG00000260027 - ... "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663-674. ... "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663-674. ... This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a ...
https://en.wikipedia.org/wiki/HOXB7
Ribosomal s6 kinaseRibosomal s6 kinase
p90rsk also regulates transcription factors including cAMP response element-binding protein (CREB); estrogen receptor-α (ERα); ... Ribosomal+Protein+S6+Kinases,+90-kDa at the US National Library of Medicine Medical Subject Headings (MeSH) Ribosomal+Protein+ ... Erikson, Eleanor; Maller, James L. (1985). "A Protein Kinase from Xenopus Eggs Specific for Ribosomal Protein S6". PNAS. 82 (3 ... including other ribosomal proteins. Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 ( ...
https://en.wikipedia.org/wiki/Ribosomal_s6_kinase
Deficiency of RbAp48 protein and memory lossDeficiency of RbAp48 protein and memory loss
CREB-binding protein, also known as CREBBP or CBP, is a protein that is encoded by the CREBBP gene in humans. The CREB protein ... "Histone Binding Protein RbAp48 Interacts with a Complex of CREB Binding Protein and Phosphorylated CREB". Molecular and ... and the interferon response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a ... This process involves many proteins, one of which is the Histone-binding protein RbAp48 (also known as RBBP4 or NURF55), ...
https://en.wikipedia.org/wiki/Deficiency_of_RbAp48_protein_and_memory_loss
Androgen receptorAndrogen receptor
CREB-binding protein, Cyclin D1, Cyclin-dependent kinase 7, DACH1, Death associated protein 6, L-DOPA, EFCAB6, Epidermal growth ... Frønsdal K, Engedal N, Slagsvold T, Saatcioglu F (November 1998). "CREB binding protein is a coactivator for the androgen ... Aarnisalo P, Palvimo JJ, Jänne OA (March 1998). "CREB-binding protein in androgen receptor-mediated signaling". Proceedings of ... "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at ...
https://en.wikipedia.org/wiki/Androgen_receptor
CREBCREB
The activated CREB protein then binds to a CRE region, and is then bound to by CBP (CREB-binding protein), which coactivates it ... Abnormalities of a protein that interacts with the KID domain of CREB, the CREB-binding protein, (CBP) is associated with ... CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences ... CREB also has a role in photoentrainment in mammals. The following genes encode CREB or CREB-like proteins: CREB1 (CREB1) CREB2 ...
https://en.wikipedia.org/wiki/CREB
Sterol regulatory element-binding protein 1Sterol regulatory element-binding protein 1
CREB-binding protein, DAX1 LMNA, and TWIST2. BHLHE40 BHLHE41 Sterol regulatory element-binding protein GRCh38: Ensembl release ... Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 ( ... "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22 ... DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)". The Journal of ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_1
RPS6KA3RPS6KA3
... has been shown to interact with CREB-binding protein, MAPK1 and PEA15. GRCh38: Ensembl release 89: ENSG00000177189 - ... Du K, Montminy M (December 1998). "CREB is a regulatory target for the protein kinase Akt/PKB". The Journal of Biological ... Paudel HK (November 1997). "Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro ... protein S6 kinase, 90kDa, polypeptide 3, also s RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene. This gene ...
https://en.wikipedia.org/wiki/RPS6KA3
Protein SETProtein SET
"Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and ... Protein SET, also known as Protein SET 1, is a protein that in humans is encoded by the SET gene. Protein SET has been shown to ... a novel protein that binds to the acute undifferentiated leukemia-associated protein SET" (PDF). European Journal of ... Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and ...
https://en.wikipedia.org/wiki/Protein_SET
POU2F3POU2F3
A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036-44. doi:10.1074/ ... POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene. GRCh38: Ensembl release ... v t e (Genes on human chromosome 11, All stub articles, Human chromosome 11 gene stubs, POU-domain proteins). ... 2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. ...
https://en.wikipedia.org/wiki/POU2F3
MAFGMAFG
Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)- ... and Bach proteins (BACH1 and BACH2). sMaf homodimers bind to a palindromic DNA sequence called the Maf recognition element ( ... "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming ... "Picosecond-hetero-FRET microscopy to probe protein-protein interactions in live cells". Biophysical Journal. 83 (6): 3570-7. ...
https://en.wikipedia.org/wiki/MAFG
Follicular lymphomaFollicular lymphoma
... encodes CREB-binding protein which contributes to the activation of various genes); 3) TNFSF14 (encodes tumor necrosis factor ... Most such regimens add rituximab (a monoclonal antibody which binds and thereby kills the CD20 cell surface protein on B cells ... None of these protein markers or genomic abnormalities are diagnostic for FL, e.g. the t(14:18)(q32:q21.3) translocation is ... Suspect mutations include those in the following genes: 1) EZH2 (encodes polycomb repressive complex 2 family protein which is ...
https://en.wikipedia.org/wiki/Follicular_lymphoma
Sirtuin 2Sirtuin 2
Shimazu T, Horinouchi S, Yoshida M (Feb 2007). "Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3 ... SIRT2 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin ... The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from ... Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular ...
https://en.wikipedia.org/wiki/Sirtuin_2
CLOCKCLOCK
This dimer then recruits co-activator CREB-binding protein (CBP) and is further phosphorylated. Once phosphorylated, this CLK- ... proteins causes formation of the PER-TIM heterodimer which prevents the CLK-CYC heterodimer from binding to the E-boxes of per ... leading to the degradation of both proteins. Hypophosphorylated CLK then accumulates, binds to the E-boxes of per and tim and ... The binding of CLOCK-BMAL to an E-box promoter element activates transcription of clock genes such as per1, 2, and 3 and tim in ...
https://en.wikipedia.org/wiki/CLOCK
SKI proteinSKI protein
The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB ... "Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling". J ... "The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription". Proc. Natl. Acad. ... The SnoN protein was identified as a similar protein and is often discussed in conjugation with the Ski protein in publications ...
https://en.wikipedia.org/wiki/SKI_protein
Homeobox protein SIX1Homeobox protein SIX1
... and Dach proteins mediated through CREB binding protein". Molecular and Cellular Biology. 22 (19): 6759-66. doi:10.1128/MCB. ... which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. Genes in the ... Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream ... Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene. The vertebrate ...
https://en.wikipedia.org/wiki/Homeobox_protein_SIX1
Nuclear receptor coactivator 2Nuclear receptor coactivator 2
"Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor ... Jimenez-Lara AM, Heine MJ, Gronemeyer H (2000). "Cloning of a mouse glucocorticoid modulatory element binding protein, a new ... "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation ... "The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent ...
https://en.wikipedia.org/wiki/Nuclear_receptor_coactivator_2
STAT6STAT6
CREB-binding protein, EP300, IRF4, NFKB1, Nuclear receptor coactivator 1, and SND1. Gene fusion Recurrent somatic fusions of ... STAT6 shares structural similarity with the other STAT proteins and is composed of the N-terminal domain, DNA binding domain, ... NGFI-A-binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors ... family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene ...
https://en.wikipedia.org/wiki/STAT6
TGS1TGS1
... has been shown to interact with: CREB-binding protein, and EED, EP300, MED1, and NCOA6. GRCh38: Ensembl release 89: ... Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a ... Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with ... Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (2003). "Different isoforms of PRIP-interacting protein with ...
https://en.wikipedia.org/wiki/TGS1
Estrogen receptor betaEstrogen receptor beta
"Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating ... Upon binding to 17-β-estradiol, estriol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with ... Thus, ERβ helps control Aβ levels by maintaining the protein it is derived from, β-amyloid precursor protein. ERβ helps by up- ... The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus ...
https://en.wikipedia.org/wiki/Estrogen_receptor_beta
Food-entrainable oscillatorFood-entrainable oscillator
... binding protein (CREB) also play a role and may be involved as part of FEO location. It has been suggested that the CREB in ... Clock genes are transcribed and translated into a protein product, and this protein accumulates and inhibits the promoter of ... In both rat and hamster models, light stimulus at night has been found to increase CREB phosphorylation and this has led to ... It is believed that feeding-induced alterations of a possible FEO site such as the CREB only take place in peripheral tissues, ...
https://en.wikipedia.org/wiki/Food-entrainable_oscillator
MECOMMECOM
EVI1 has been shown to interact with: CREB binding protein, CTBP1, HDAC1, Mothers against decapentaplegic homolog 3, and PCAF ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ... Studies show that EVI1 also binds to known coactivators cAMP responsive element binding protein (CBP) and p300/CBP-associated ...
https://en.wikipedia.org/wiki/MECOM
RPS6KA4RPS6KA4
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377-32379. ... 2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169-5178. doi: ... is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): ... Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene. This gene encodes a member of ...
https://en.wikipedia.org/wiki/RPS6KA4
Neural backpropagationNeural backpropagation
... action potentials have been shown to induce BDNF-dependent phosphorylation of cyclic AMP response element-binding protein (CREB ...
https://en.wikipedia.org/wiki/Neural_backpropagation
Epigenetics of neurodegenerative diseasesEpigenetics of neurodegenerative diseases
Rouaux C, Loeffler JP, Boutillier AL (September 2004). "Targeting CREB-binding protein (CBP) loss of function as a therapeutic ... "Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve ... As that gene's name suggests, BACE1 is an enzymatic protein that cleaves the Amyloid Precursor Protein into the insoluble ... Mutations in UBQLN2 interfere with protein degradation resulting in neurodegeneration through abnormal protein aggregation. ...
https://en.wikipedia.org/wiki/Epigenetics_of_neurodegenerative_diseases
CREB1CREB1
"Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and ... This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein ... "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249- ... CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This ...
https://en.wikipedia.org/wiki/CREB1
Interleukin 16Interleukin 16
"GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin ... It's precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene. This gene was discovered in 1982 at ... Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of ... Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of ...
https://en.wikipedia.org/wiki/Interleukin_16
CREB in cognitionCREB in cognition
The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and ... While viral CREB reversed the conditioning deficits in CREB knockout animals, additional CREB did not seem to enhance memory of ... When a herpes simplex virus expressing CREB was infused into the amygdala of CREB knockout mice, the expression of CREB in the ... CREB for binding sites in the DNA; the transgenic protein lacks the domains required for making functional complexes. To ...
https://en.wikipedia.org/wiki/CREB_in_cognition
Homeobox protein MSX-1Homeobox protein MSX-1
MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 (3): 751-758. doi: ... Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)". The Biochemical Journal. 339 (3): 751-758. doi: ... MSX1 and LHX2 form a protein complex in the absence of DNA, and that DNA binding by either protein alone can occur at the ...
https://en.wikipedia.org/wiki/Homeobox_protein_MSX-1
Mucoepidermoid carcinomaMucoepidermoid carcinoma
The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation ... cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". ...
https://en.wikipedia.org/wiki/Mucoepidermoid_carcinoma
PDE4DPDE4D
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (Feb 2001). "HIV-1 Tat protein down-regulates CREB ... MacKenzie SJ, Baillie GS, McPhee I, Bolger GB, Houslay MD (Jun 2000). "ERK2 mitogen-activated protein kinase binding, ... The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the ... Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999). "The RACK1 signaling scaffold protein selectively ...
https://en.wikipedia.org/wiki/PDE4D
Forkhead box protein O1Forkhead box protein O1
"DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in ... CREB-binding protein, and tuberous sclerosis protein 2. GRCh38: Ensembl release 89: ENSG00000150907 - Ensembl, May 2017 GRCm38 ... Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by ... protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein ...
https://en.wikipedia.org/wiki/Forkhead_box_protein_O1
Human genetic enhancementHuman genetic enhancement
Recently, it was also shown that the gene transfer of CBP (CREB (c-AMP response element binding protein) binding protein) ... Reduction of p11, a serotonin receptor binding protein, in the nucleus accumbens led to depression-like behaviour in rodents, ... Gavish B, Gratton E, Hardy CJ (February 1983). "Adiabatic compressibility of globular proteins". Proceedings of the National ... interfered with CREB activity which is physiologically involved in memory formation. In another study, it was shown that Aβ ...
https://en.wikipedia.org/wiki/Human_genetic_enhancement
NCOA6NCOA6
... has been shown to interact with: ASCL2 and Activating transcription factor 2, Androgen receptor, CREB-binding protein, ... Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ... "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. ...
https://en.wikipedia.org/wiki/NCOA6
Alpha cellAlpha cell
... protein kinase A (PKA) is activated and phosphorylates the transcription factor cAMP Response Element Binding (CREB) protein. ... Somatostatin inhibits glucagon secretion through the activation of SSTR2, a membrane bound protein that when activated causes a ... Glucagon will bind to the glucagon receptors on the plasma membranes of hepatocytes (liver cells). This ligand binding causes ... This protein channel allows zinc to cross the plasma membrane into the cell. When ZnT8 is under-expressed, there is a marked ...
https://en.wikipedia.org/wiki/Alpha_cell
Picornain 3CPicornain 3C
Also, 3C and 2A are responsible for down-regulation of cyclic AMP responsive element binding protein (CREB), a cellular ... binding protein, PABP. This disruption of this binding domain results in down regulation of the initiation of cap dependent ... P1 encodes for a proteins (VP1, VP2, VP3, and VP4) that make the capsid proteins. P2 and P3 proteins assist in infectivity of ... Polioviruses' protease 3C is responsible for host cell transcription shut off by cleaving the TATA-binding protein and other ...
https://en.wikipedia.org/wiki/Picornain_3C
RBBP7RBBP7
"Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Mol. Cell. Biol. 20 ( ... Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. This protein is a ubiquitously ... It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The ... Huang S, Lee WH, Lee EY (1991). "A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene ...
https://en.wikipedia.org/wiki/RBBP7
Phosphoenolpyruvate carboxykinasePhosphoenolpyruvate carboxykinase
... in the liver which consequently leads to the phosphorylation of S133 on a beta sheet in the CREB protein. CREB then binds ... In addition, hyper-reactive cysteine (C307) is involved in the binding of Mn2+ to the active site. As discussed previously, ... PEP transport across the inner mitochondrial membrane involves the mitochondrial tricarboxylate transport protein and to a ... Protein Expression and Purification. 31 (2): 298-304. doi:10.1016/S1046-5928(03)00189-X. PMID 14550651. Liu K, Ba X, Yu J, Li J ...
https://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase
ZGRF1ZGRF1
The transcriptional start site for ZGRF1 aligns best with ATF, CREB, deltaCREB, E2F, and E2F-1 transcription factor binding ... ZGRF1 is a protein in humans that is encoded by the ZGRF1 gene that has a weight of 236.6 kDa. The ZGRF1 gene product localizes ... A majority of these proteins are in the RNA helicase family. There are no known paralogs to the large N-terminal portion of the ... A weak transmembrane domain is predicted in the TMHMM server with one loop in the C-terminus of the protein prior to the ...
https://en.wikipedia.org/wiki/ZGRF1
Cassava SciencesCassava Sciences
"Retraction: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling and CREB Activation of ... Filaman A (FLNA) is a protein that Cassava Sciences says becomes misshaped in people with Alzheimer's, leading to amyloid ... Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling and CREB Activation of Acute Morphine ... Wang HY, Lee KC, Pei Z, Khan A, Bakshi K, Burns LH (July 2017). "PTI-125 binds and reverses an altered conformation of filamin ...
https://en.wikipedia.org/wiki/Cassava_Sciences
Tapas Kumar KunduTapas Kumar Kundu
... a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone ... protein) M. R. S. Rao India portal Biology portal His thesis won the Giri Memorial Award for best thesis in Biochemistry. ... Compounds that selectively bind to copper ions in a sample and methods of preparation and use - Patent No. 8642764. {{cite web ... Zinc-Metalloprotein Nature of Rat Spermatidal Protein TP2 and its Interactions with DNA. After a short stint at the National ...
https://en.wikipedia.org/wiki/Tapas_Kumar_Kundu
CYR61CYR61
"Silencing cAMP-response element binding protein (CREB) identifies cysteine-rich protein 61 (CYR61) as a tumor suppressor gene ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, von Willebrand ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ...
https://en.wikipedia.org/wiki/CYR61
cAMP response element-binding protein (CREB) regulates differentiation and survival of newborn neurons in the olfactory bulbcAMP response element-binding protein (CREB) regulates differentiation and survival of newborn neurons in the olfactory bulb
... C ... The transcription factor cAMP response element-binding protein (CREB) is involved in multiple aspects of neuronal development ... The transcription factor cAMP response element-binding protein (CREB) is involved in multiple aspects of neuronal development ... 2_cAMP response element-binding protein (CREB) regulates differentiation and survival of newborn neurons in the olfactory bulb ...
https://iris.unito.it/handle/2318/98778
CBP/KAT3A Antibody [Janelia Fluor® 549] (NBP2-98753JF549): Novus BiologicalsCBP/KAT3A Antibody [Janelia Fluor® 549] (NBP2-98753JF549): Novus Biologicals
CREB binding protein. *CREB-binding protein. *CREBBP. *EC 2.3.1.48. *KAT3A. *RSTS ...
https://www.novusbio.com/products/cbp-kat3a-antibody_nbp2-98753jf549
The human T-cell leukemia virus-1 transcriptional activator tax enhances cAMP-responsive element-binding protein (CREB) binding...The human T-cell leukemia virus-1 transcriptional activator tax enhances cAMP-responsive element-binding protein (CREB) binding...
... the target of cAMP responsive element-binding protein (CREB). CREB binds the TxRE with reduced affinity; however, the ... the target of cAMP responsive element-binding protein (CREB). CREB binds the TxRE with reduced affinity; however, the ... the target of cAMP responsive element-binding protein (CREB). CREB binds the TxRE with reduced affinity; however, the ... the target of cAMP responsive element-binding protein (CREB). CREB binds the TxRE with reduced affinity; however, the ...
https://ohsu.pure.elsevier.com/en/publications/the-human-t-cell-leukemia-virus-1-transcriptional-activator-tax-e-2
MedlinePlus: Genes: CMedlinePlus: Genes: C
CREBBP: CREB binding protein. *CRLF1: cytokine receptor like factor 1. *CRPPA: CDP-L-ribitol pyrophosphorylase A ... CHD2: chromodomain helicase DNA binding protein 2. *CHD3: chromodomain helicase DNA binding protein 3 ... CHD7: chromodomain helicase DNA binding protein 7. *CHD8: chromodomain helicase DNA binding protein 8 ...
https://medlineplus.gov/genetics/gene-c/
Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fearActivation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear
CREB-Binding Protein Grant support * U54 NS039406/NS/NINDS NIH HHS/United States ... In addition, oral administration of DMP696 significantly reduced phosphorylation of cyclic AMP response element-binding protein ...
https://pubmed.ncbi.nlm.nih.gov/17988803/?dopt=Abstract
RCSB PDB - 1R8U: NMR structure of CBP TAZ1/CITED2 complexRCSB PDB - 1R8U: NMR structure of CBP TAZ1/CITED2 complex
CREB-binding protein. B. 100. Mus musculus. Mutation(s): 0 Gene Names: Crebbp, Cbp. EC: 2.3.1.48 (UniProt), 2.3.1 (UniProt). ... Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition ... The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 ... The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 ...
https://www.rcsb.org/structure/1r8u
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA | Nature NeurosciencePolyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA | Nature Neuroscience
We found that polyQ-AR reduced long-term protein turnover and impaired autophagic flux in motor neuron-like cells. ... CREB-binding protein sequestration by expanded polyglutamine. Hum. Mol. Genet. 9, 2197-2202 (2000). ... Supplementary Figure 1 Reduced long-term protein turnover in MN-1 AR65Q cells.. After labeling of newly synthesized proteins ... We noted a significantly reduced rate of long-term protein turnover for MN-1 AR65Q cells in comparison to wild-type MN-1 cells ...
https://www.nature.com/articles/nn.3787?error=cookies_not_supported&code=23bc4947-1893-4322-b012-710246158e2c
Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization - Oxford...
Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization ... Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization ... Cells, Cultured Chromosome Mapping *Chromosomes, Human, Pair 16 Human In Situ Hybridization, Fluorescence Nuclear Proteins/* ...
https://www.cardioscience.ox.ac.uk/publications/165130
CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons | Journal of...CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons | Journal of...
The CREB family has two types of coactivators. First, CREB binding protein (CBP) and its paralogue p300 (Lundblad et al., 1995 ... CREB protein levels were normalized to total protein levels, and P-CREB protein levels were normalized to CREB protein levels. ... P-CREB protein levels were normalized to total CREB protein levels, and the relative level of P-CREB protein in nontreated ... P-CREB) protein levels and Coomassie staining for loading control. C, Quantification of total CREB protein levels. CREB protein ...
https://www.jneurosci.org/content/40/7/1405
KEGG PATHWAY: hsa05167
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]. 2033 EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]. ... MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]. 5595 MAPK3; mitogen-activated protein kinase 3 [KO:K04371 ... MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]. 6300 MAPK12; mitogen-activated protein kinase 12 [KO: ... MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]. 1432 MAPK14; mitogen-activated protein kinase 14 [KO: ...
https://www.genome.jp/dbget-bin/www_bget?pathway+hsa05167
Interactions between corticosteroids and β agonists | ThoraxInteractions between corticosteroids and β agonists | Thorax
CREB binding protein; CRE = cAMP response element; CREB = cAMP response element binding protein; cAMP = cyclic adenosine ... It is likely that "cross talk" includes competitive binding of protein co-factors such as CREB binding protein (CBP) or the ... are bound to protein complexes (including heat shock protein, HSP-90) in the cytosol. After ligand binding, activated GRs ... 5) The glucocorticoid receptor and CREB may compete for or synergistically bind protein co-factors such as CBP which are ...
https://thorax.bmj.com/content/55/7/595
lung small cell carcinoma - Ontology Report - Rat Genome Databaselung small cell carcinoma - Ontology Report - Rat Genome Database
CREB binding protein. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:22941188. NCBI chr10:11,335,551...11,461,888 ... ELAV like RNA binding protein 2. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:22941189. NCBI chr 5:105,960,872... ... E1A binding protein p300. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:22941188. NCBI chr 7:113,108,476...113,178,529 ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer ( ...
https://rgd.mcw.edu/rgdweb/ontology/annot.html?species=Rat&acc_id=DOID:5409
Available Clones(KOP)
CREB binding protein, transcript variant 1. CREBBP. ---. ---. ORK07683. ---. ---. CREB-binding protein Gene Symbol Aliases. ...
http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=CREBBP
SCOPe 2.08: Domain d3p1fa1: 3p1f A:1081-1197SCOPe 2.08: Domain d3p1fa1: 3p1f A:1081-1197
PDB Compounds: (A:) creb-binding protein. SCOPe Domain Sequences for d3p1fa1:. Sequence; same for both SEQRES and ATOM records ... Protein automated matches [190366] (2 species). not a true protein. *. Species Human (Homo sapiens) [TaxId:9606] [187201] (46 ... Other proteins in same PDB: d3p1fa2. automated match to d1jspb_. complexed with 3pf, edo, k. ... Class a: All alpha proteins [46456] (290 folds). *. Fold a.29: Bromodomain-like [47363] (15 superfamilies). 4 helices; bundle; ...
http://scop.berkeley.edu/sunid=183451
PDF] Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis...PDF] Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis...
Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis ... Sevoflurane-mediated downregulation of cAMP/CREB and BDNF/TrkB signalling was inhibited by EGCG. Reverse transcription PCR ... inhibit sevoflurane-induced neurodegeneration and improve learning and memory retention of mice via activation of CREB/BDNF/ ... inhibit sevoflurane-induced neurodegeneration and improve learning and memory retention of mice via activation of CREB/BDNF/ ...
https://www.semanticscholar.org/paper/Protective-effects-of-a-green-tea-polyphenol%2C-of-in-Ding-Ma/58b83064eb0a0606b456240aba936c8b912ab453?p2df
Frontiers | Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive DeclineFrontiers | Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline
... mitogen activated protein kinase; FOXO, forkhead box O transcription factor; CREB, cAMP response element-binding protein. ... and the transcription factors cAMP response element-binding protein (CREB) and forkhead box O (FOXO) family (Fernandez and ... protein kinase B; mTOR, target of rapamycin; GSK3β, glycogen synthase kinase 3 beta; GRB2, growth factor receptor-bound protein ... 2012b). A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc. Natl. ...
https://www.frontiersin.org/articles/10.3389/fnins.2019.00788/full
Publications by Roman A. Eliseev, M.D., Ph.D. - University of Rochester Medical CenterPublications by Roman A. Eliseev, M.D., Ph.D. - University of Rochester Medical Center
"Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and ... "High-Yield Expression and Purification of p18 Form of Bax as an MBP-Fusion Protein." Prot Expr Purif. 2004; : 206-209. ... "Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport." Biochimica et biophysica acta.. 2003 Apr 18; 1604( ... "Bone Morphogenic Protein-2 Signaling in Human Disc Degeneration and Correlation to the Pfirrmann MRI Grading System." The ...
https://www.urmc.rochester.edu/people/21881749-roman-a-eliseev/publications
MPD: Genes and genomic regionsMPD: Genes and genomic regions
protein coding gene. CREB binding protein. Tssr139753. 16. 4086126 to 4086140 14. -. TSS region. transcription start site ... protein coding gene. TNF receptor-associated protein 1. Tssr139751. 16. 4045157 to 4045163 6. -. TSS region. transcription ... protein coding gene. deoxyribonuclease I. Tssr136844. 16. 4037092 to 4037103 11. +. TSS region. transcription start site region ... protein coding gene. SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). Cpgi7904. 16. 4003354 to 4004172 818 ...
https://phenome.jax.org/markers/search?searchterm=16%3A3981334-4313413
Publications | National Institute on Alcohol Abuse and Alcoholism | Update on the Genetics of AlcoholismPublications | National Institute on Alcohol Abuse and Alcoholism | Update on the Genetics of Alcoholism
CREB) protein and CREB-binding protein (CBP) in the epigenetic regulation of gene expression. CREB is activated after its ... Phosphorylated CREB (pCREB) then recruits another transcriptional co-factor called CREB-binding protein (CBP), which contains ... CREB) protein. This protein helps modulate the transcription of certain genes by binding to a specific sequence on the DNA ... CREB binding protein is required for both short-term and long-term memory formation. Journal of Neuroscience 30:13066-13077, ...
https://pubs.niaaa.nih.gov/publications/arcr343/293-305.htm
Cells | Free Full-Text | Nerve, Muscle, and SynaptogenesisCells | Free Full-Text | Nerve, Muscle, and Synaptogenesis
... bone morphogenic protein 4 [175,176], and, through the intermediation of their dedicated binding proteins, insulin growth ... CREB) modulation. J. Biol. Chem. 2013, 288, 35222-35236. [Google Scholar] [CrossRef] [PubMed][Green Version] ... Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell ... Zhang, W.; Coldefy, A.S.; Hubbard, S.R.; Burden, S.J. Agrin binds to the N-terminal region of Lrp4 protein and stimulates ...
https://www.mdpi.com/2073-4409/8/11/1448
Genetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, EpidemiologyGenetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, Epidemiology
... in the cAMP response element-binding protein (CREB)-binding protein (CBP) gene or from EP300 mutations. [4, 5] ... 16p13 deletion syndrome - A submicroscopic, proximal deletion on chromosome 16p13.3, which includes the CREB-binding protein ( ...
https://emedicine.medscape.com/article/948453-overview
Reconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate TumorsReconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate Tumors
CREB-binding protein) [57] which then can bind with AR and can enhance AR activity [57, 58] (Figure 4, bold green lines). ... IRE3 activates transcription factor XBP1 (X-box binding protein 1) which regulates a number of proteins involved in protein ... CREB-binding protein in androgen receptor-mediated signaling. Proc Natl Acad Sci U S A. 1998;95:2122-2127 ... Fronsdal K, Engedal N, Slagsvold T, Saatcioglu F. CREB binding protein is a coactivator for the androgen receptor and mediates ...
https://jcancer.org/v06p0490.htm
ORVOSI SZÓTÁR - C-reaktív protein (CRP) jelentése
acute phase protein - English → Magyar. Akute-Phase-Protein - Deutsch → Magyar. CREB-binding protein - English → Magyar. C- ... CREB-binding protein (CBP) - English → Magyar. Protein losing enteropathy - Magyar → szinonima. protein-free hemodialysate - ... protein crops - English → Magyar. total protein - English → Magyar. protein bound - English → keresési javaslat. blood protein ... plasma protein - English → Magyar. protein kináz - Magyar → értelmezés. Protein Folding - English → Magyar. Protein Binding - ...
https://super55.com/index.php?s=1&q=C-reakt%C3%ADv+protein+%28CRP%29
WikiGenes - TFAP2A - transcription factor AP-2 alpha...WikiGenes - TFAP2A - transcription factor AP-2 alpha...
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. Bragança, J., ... The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells ... Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. ... Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human ...
https://www.wikigenes.org/e/gene/e/7020.html
Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical...Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical...
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve ... eight postnatal weeks in mice), the widely expressed methyl binding protein MeCP2 is required for proper development and/or ... Dobreva G, Dambacher J, Grosschedl R. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene ... Combined with the protein expression data in Fig 4, these results demonstrated that Sirt1 mRNA and protein are specifically and ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254113
Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with...Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with...
One downstream effector of CaMKIV is cAMP response element-binding protein (CREB; Redmond et al., 2002). In normal mice, a high ... or downstream signaling proteins, such as mitogen-activated protein kinases (MAPKs) and protein kinase A (PKA; Ghosh and ... Brain-derived neurotrophic factor (BDNF) is a key downstream target of CREB. The expression of phospho-CREB in immature adult- ... Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci 22: ...
https://www.eneuro.org/content/6/2/ENEURO.0110-18.2019.full
Huntington Disease: Background, Pathophysiology, EtiologyHuntington Disease: Background, Pathophysiology, Etiology
Recent work suggests that polyglutamine interference with transcription of CREB binding protein (CBP), a major mediator of ... Caspases, among other proteins, cleave huntingtin within the N-terminal region. To address the question of a potential in vivo ... The role of caspases (a class of highly specific proteases) in apoptosis involves cleavage of target proteins at different ... One theory is that expanded polyglutamine repeats cause neuronal degeneration through abnormal interactions with other proteins ...
https://emedicine.medscape.com/article/1150165
Necessities 100 - Bear Necessities Pediatric Cancer Foundation
We are developing a small molecule that blocks the interaction of CREB and its binding partner CBP (CREB Binding Protein). We ... leukemia (ALL). CREB (cAMP Response Element Binding Protein) is a protein that is overproduced in leukemia cells from patients ... In addition, overexpression of the CREB protein in AML patients was associated with an increased risk of relapse and decrease ... CREB INHIBITORS FOR RELAPSED LEUKEMIA. Dr. Kathleen Sakamoto, MD., PhD. Stanford University. The overall survival of pediatric ...
https://bearnecessities.org/get-involved/necessities-100/
Post-Translational Modifications Of Β-Catenin And TCF/LEF-1 Regulate Canonical Wnt SignalingPost-Translational Modifications Of Β-Catenin And TCF/LEF-1 Regulate Canonical Wnt Signaling
... in beta-catenins role as a co-transcriptional factor with the DNA binding proteins TCF (T cell factor) and LEF-1 (lymphoid ... Acetylation of beta-catenin by CREB-binding protein (CBP). J. Biol. Chem. 277, 25562-25567. ... The binding affinity between TCF/LEF-1 and co-regulators is significantly affected by each proteins respective PTM status (Fig ... In the absence of Wnt binding to the co-receptor complex of Frizzled (Fz) and low-density lipoprotein receptor-related proteins ...
https://www.cytoskeleton.com/post-translational-modifications-of-beta-catenin-and-tfc-lef-1-regulate-canonical-wnt-signaling
CREBBPCAMP responsKinaseP300PhosphorylationOverexpressionCoactivatorsHistoneGenesBDNFVitroNuclear proteinMutationsNeuronsTranscriptionalScaffold proteinModulateInhibitorsDownregulationRegulatesResponsiveAffinityInteractionZincRNAsGene encodesDominant-negativeFluorescenceMotifEncodesNitric oxideCellularSynthesisMembraneNucleusReceptorViralFamilySCOPeFoldsPathwaysRegulationHeat shock pIncreasesCalmodulinKinasesRepressorEnhances
CREBBP1
  • Causes of Rubinstein-Taybi syndrome include: a microdeletion of chromosome 16p13.3 or chromosome 22q13.2, a variant in CREB-binding protein ( CREBBP , 16p13.3) or a variant in E1A-binding protein p300 ( EP300 , 22q13.2). (orpha.net)
CAMP respons8
  • The transcription factor cAMP response element-binding protein (CREB) is involved in multiple aspects of neuronal development and plasticity. (unito.it)
  • Most cases arise from sporadic, fresh mutations (1% recurrence risk) in the cAMP response element-binding protein (CREB)-binding protein ( CBP ) gene or from EP300 mutations. (medscape.com)
  • CREB (cAMP Response Element Binding Protein) is a protein that is overproduced in leukemia cells from patients with AML. (bearnecessities.org)
  • Elevations of cAMP in cells activate PKA, which in turn phosphorylates cAMP-response element binding protein (CREB) to induce gene expression. (llhf.org)
  • Contrarily, methyl CpG binding protein 2 (MeCP2) were dramatically reduced in 50 and 100 mg/L NaF groups, while cAMP-response element binding protein (CREB) mRNA level was significantlydecreased in all fluoride groups. (greenmedinfo.com)
  • Activator protein (AP)‐1, cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), nuclear factor of activated T‐cells (NFAT), nuclear factor (NF)‐κB, the serum response element (SRE) complex and signal transducer and activator of transcription (STAT) are all known to be involved in proliferation and/or inflammation and have been implicated in the inflammatory state causing asthma and related airway diseases 8 . (ersjournals.com)
  • The number of cells in superficial and deep dorsal horn laminae at the L4-L5 level immunostained for phosphorylated cAMP response element binding protein (pCREB) were quantified. (asahq.org)
  • A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. (bvsalud.org)
Kinase5
  • Evidence is provided to support the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol-3 kinase/ protein kinase B (PI3K/AKT) pathways in EGCG-mediated protection against corticosterone-induced neuron injuries. (semanticscholar.org)
  • In the absence of Wnt binding to the co-receptor complex of Frizzled (Fz) and low-density lipoprotein receptor-related proteins (LRP) 5 and 6, a multi-protein destruction complex consisting of the scaffolding/tumor suppressor proteins Axin and adenomatous polyposis coli (APC), and the serine/threonine kinases casein kinase 1α (CK-1α) and glycogen synthase kinase 3 (GSK3) mediates phosphorylation of β-catenin 2,3,9 . (cytoskeleton.com)
  • One key proliferative signalling mediator is the extracellular signal-regulated kinase (ERK), a member of the mitogen-activation protein kinase (MAPK) family, and both LPA and EGF signal through ERK in many cell types 6 , 7 . (ersjournals.com)
  • The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
  • CHIR 99021 is a small organic molecule that inhibits GSK3α and GSK3β by competing for their ATP-binding sites.In vitro kinase assays reveal that CHIR 99021 specifically inhibits GSK3β (IC50=~5 nM) and GSK3α (IC50=~10 nM), with little effect on other kinases[2]. (dcchemicals.com)
P3002
  • We show that CREB family transcription factors, together with the coactivator CBP/p300, but not the CRTC family, are the main regulators of rat BDNF gene expression after TrkB signaling. (jneurosci.org)
  • Cited-2 binds to the CH1 region of CREB binding protein (CBP)/p300 and blocks its ability to interact with HIF-1 alpha and STAT2. (rndsystems.com)
Phosphorylation9
  • Combining immunohistochemistry with bromodeoxyuridine treatments, cell tracer injections, cell transplants, and quantitative analyses, we show that although CREB is expressed by the SVZ neuroblasts throughout the neurogenic process, its phosphorylation is transient and parallels neuronal differentiation, increasing during the late phase of tangential migration and decreasing after dendrite elongation and spine formation. (unito.it)
  • This finding is further supported by peripheral afferent denervation experiments resulting in downregulation of CREB phosphorylation in neuroblasts, the survival of which appears heavily impaired. (unito.it)
  • In addition, oral administration of DMP696 significantly reduced phosphorylation of cyclic AMP response element-binding protein (pCREB) in the lateral and basolateral amygdala nuclei, but not in the CeA, during the post-fear conditioning period. (nih.gov)
  • 6) Direct phosphorylation of protein co-factors such as CBP may alter their activity. (bmj.com)
  • Protein post-translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, and SUMOylation, to name but a few, have evolved to diversify the functions of a single protein and account for the vast increase in proteome complexity and functional diversity 1 . (cytoskeleton.com)
  • Upon phosphorylation, the E3 ubiquitin ligase β-transducin repeats containing protein (β-TrCP) ubiquitinates phospho-β-catenin on Lys19 and Lys49 13,14 , which leads to proteasomal destruction and low β-catenin levels and activity 15,16 . (cytoskeleton.com)
  • Stabilization occurs through partial inhibition of CK-1α and GSK318, inhibition of β-TrCP20, phosphorylation of five highly conserved PPPSP motifs in LRP6's intracellular domain 21,22 (Fig.1), and subsequent aggregation of these Wnt signaling proteins. (cytoskeleton.com)
  • This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. (bris.ac.uk)
  • These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition. (bris.ac.uk)
Overexpression2
  • In the current study, we have investigated this phenomenon in primary cultures of rat cortical neurons using overexpression of dominant-negative forms of several transcription factors, including CREB, ATF2, C/EBP, USF, and NFAT. (jneurosci.org)
  • In addition, overexpression of the CREB protein in AML patients was associated with an increased risk of relapse and decrease in survival. (bearnecessities.org)
Coactivators1
  • SIKs can modulate energy metabolism through phosphorylating CREB regulated transcription coactivators (CRTCs) and class IIa histone deacetylases (HDACs) respectively, revealing that SIKs govern two downstream branches of cAMP signaling to regulate gene expression and diverse metabolic programs. (llhf.org)
Histone2
  • Epigenetic alterations include the direct addition of methyl groups to (i.e., methylation of) DNA and the chemical modification of the proteins around which the DNA is wrapped (i.e., histone proteins) to form the chromosomes. (nih.gov)
  • Luckily, nature has evolved histone proteins to wind up the extremely long nucleotide into a manageable package. (alzforum.org)
Genes5
  • 5) The glucocorticoid receptor and CREB may compete for or synergistically bind protein co-factors such as CBP which are required for coupling with RNA polymerase and activation of response elements in the promoter regions of target genes. (bmj.com)
  • In canonical Wnt-mediated signaling, β-catenin is a key effector and interacts, as a co-transcription factor, with the DNA binding proteins TCF (T cell factor) and LEF-1 (lymphoid enhancer factor 1) to activate the transcription of Wnt/β-catenin target genes including cyclin D1, c-jun, and c-myc 8-11 (Fig. 1). (cytoskeleton.com)
  • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. (biologists.com)
  • Ubiquitination-triggered proteasomal degradation of DNA-bound NF-ĸB strongly limits the expression of its target genes. (jbc.org)
  • Using chromatin immunoprecipitation experiments, Guan and colleagues report that HDAC2 was associated with, amongst others, the promoter region of brain-derived neurotrophic factor (BDNF), Creb, and Creb-binding protein genes, all of which are implicated in memory formation. (alzforum.org)
BDNF6
  • CREB family transcription factors are required for the early induction of all the major BDNF transcripts, whereas CREB itself directly binds only to BDNF promoter IV, is phosphorylated in response to BDNF-TrkB signaling, and activates transcription from BDNF promoter IV by recruiting CBP. (jneurosci.org)
  • Our complementary reporter assays with BDNF promoter constructs indicate that the regulation of BDNF by CREB family after BDNF-TrkB signaling is generally conserved between rat and human. (jneurosci.org)
  • However, we demonstrate that a nonconserved functional cAMP-responsive element in BDNF promoter IXa in humans renders the human promoter responsive to BDNF-TrkB-CREB signaling, whereas the rat ortholog is unresponsive. (jneurosci.org)
  • Here, we have elucidated the molecular mechanisms behind TrkB signaling-dependent BDNF mRNA induction and show that CREB family transcription factors are the main regulators of BDNF gene expression after TrkB signaling. (jneurosci.org)
  • PDF] Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice. (semanticscholar.org)
  • Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. (semanticscholar.org)
Vitro2
  • In vitro, inhibition of CREB function impairs morphological differentiation of SVZ-derived neuroblasts. (unito.it)
  • HASM cells grown in vitro proliferate in response to a variety of stimuli, including G protein-coupled receptor (GPCR) agonists as well as peptide growth factors acting via receptor tyrosine kinases (RTKs) 1 , 2 . (ersjournals.com)
Nuclear protein1
  • Here we report that all these breakpoints are restricted to a region that contains the gene for the human CREB binding protein (CBP), a nuclear protein participating as a co-activator in cyclic-A IMP-regulated gene expression 9-12 . (harvard.edu)
Mutations2
  • Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME. (bvsalud.org)
  • Comprehensive screening of CREB-binding protein gene mutations among patients with Rubinstein-Taybi syndrome using denaturing high-performance liquid chromatography. (cdc.gov)
Neurons2
  • Transgenic mice lacking CREB, in a null CREM genetic background, show reduced survival of newborn neurons in the OB. (unito.it)
  • Together, these findings provide evidence that CREB regulates differentiation and survival of newborn neurons in the OB. (unito.it)
Transcriptional1
  • Tax-1, the transcriptional activation protein of human T-cell leukemia virus-1, increases transcription from the human T-cell leukemia virus-1 long terminal repeat and specific cellular promoters through interactions with cellular DNA-binding proteins. (elsevier.com)
Scaffold protein1
  • Conversely, in the presence of Wnt binding, the scaffold protein Dishevelled (Dvl) is recruited to the Fz-LRP5/6 co-receptor complex, which activates a sequence of molecular signals that inhibit the destruction complex and result in stabilization of unphosphorylated, cytosolic β-catenin and β-catenin-dependent transcription 2,3,17-19 . (cytoskeleton.com)
Modulate1
  • Recent research shows the involvement of additional proteins that modulate the function of the miRNA processing machinery, the Drosha processing complex, or microprocessor. (cdc.gov)
Inhibitors1
  • Our hope is that CREB inhibitors will lead to discovery of a new class of drugs that will be used to treat acute leukemia. (bearnecessities.org)
Downregulation1
  • 1) The steroid-glucocorticoid receptor complex upregulates β 2 receptors by enhancing β 2 receptor coupling with G protein and/or preventing downregulation following β 2 receptor activation. (bmj.com)
Regulates1
  • Here, we demonstrate that CREB regulates specific phases of adult neurogenesis in the subventricular zone/olfactory bulb (SVZ/OB) system. (unito.it)
Responsive1
  • The Tax response elements (TxREs) of the long terminal repeat resemble cAMP response elements (CREs), the target of cAMP responsive element-binding protein (CREB). (elsevier.com)
Affinity1
  • Finally, the IC-substituted TxRE binds CREB with increased affinity, suggesting flanking DNA influences the binding of CREB to the core CRE-like element. (elsevier.com)
Interaction1
  • We are developing a small molecule that blocks the interaction of CREB and its binding partner CBP (CREB Binding Protein). (bearnecessities.org)
Zinc1
  • contains a zinc finger,XV" YOL091W 1 15 16 YOL091W "involved in sporulation,XV" YOL103W-B 1 15 17 YOL103W-B "TyB Gag-Pol protein. (davidson.edu)
RNAs1
  • MicroRNAs (miRNAs) are endogenously synthesized small non-coding RNAs that regulate gene expression by interfering with protein translational machinery and/or inducing degradation of target mRNAs [ 1 ]. (cdc.gov)
Gene encodes2
  • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. (biologists.com)
  • This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. (nih.gov)
Dominant-negative1
  • Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. (bris.ac.uk)
Fluorescence1
  • Using a fluorescence quenching method, we determined that CREB dimerizes in the absence of DNA, and that Tax does not enhance dimerization. (elsevier.com)
Motif3
  • CITED2 and HIF-1alpha both contain a four residue motif, LP(E/Q)L, which binds in the TAZ1 alpha(1)/alpha(2)/alpha(3) junction in each complex. (rcsb.org)
  • XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)
  • Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers. (nih.gov)
Encodes1
  • STK11/LKB1 encodes a 433 amino acid ubiquitously expressed protein with a central catalytic domain and regulatory N- and C-terminal domains. (medscape.com)
Nitric oxide1
  • We observed that, like Sc WhiD and other Wbl proteins, Sv WhiD binds a [4Fe-4S] cluster that is moderately sensitive to O 2 and highly sensitive to nitric oxide (NO). (jbc.org)
Cellular1
  • Stress stimuli or growth factor deprivation promotes nuclear localization and activation of FoxO proteins, which-depending on the cellular context-can lead to cell cycle arrest or apoptosis. (jbc.org)
Synthesis1
  • 8) The promoter region of the β 2 receptor gene contains GREs which may enhance or suppress synthesis of the β 2 receptor protein. (bmj.com)
Membrane1
  • Glucose is the main energy source used by brain cells and its transport across the plasma membrane is mediated by a specific family of membrane proteins known as glucose transporters (GLUTs) ( Shepherd and Kahn, 1999 ). (frontiersin.org)
Nucleus5
  • 2) Binding between the activated glucocorticoid receptor and CREB in the cytoplasm may inhibit translocation to the nucleus. (bmj.com)
  • 4) "Cross talk" between the glucocorticoid receptor and CREB in the nucleus. (bmj.com)
  • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. (biologists.com)
  • After successful cleavage, the pre-miRNA is bound by exportin-5 in a ran-GTP dependant manner and exported from the nucleus [ 5 - 7 ]. (cdc.gov)
  • Interestingly, reduced binding of exportin-5 by reduction of the protein itself or alteration in the miRNA structure causes a reduced expression of the mature miRNA, without buildup of pre-miRNA in the nucleus [ 5 ]. (cdc.gov)
Receptor1
  • 3) "Cross talk" between the glucocorticoid receptor, CREB, and other nuclear transcription factors. (bmj.com)
Viral2
  • Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. (genome.jp)
  • Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies. (genome.jp)
Family2
  • The bacterial protein WhiD belongs to the Wbl family of iron-sulfur [Fe-S] proteins present only in the actinomycetes. (jbc.org)
  • XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)
SCOPe1
  • SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Folds1
  • The activation domain of CITED2 is unstructured when free and folds upon binding, forming a helix (termed alpha(A)) and an extended structure that wraps around TAZ1. (rcsb.org)
Pathways1
  • Activation of the inhibitory guanine nucleotide-binding protein and of ERK signalling pathways were required for most transcription factor responses to LPA. (ersjournals.com)
Regulation1
  • Forkhead box O (FoxO) transcription factors are conserved proteins involved in the regulation of life span and age-related diseases, such as diabetes and cancer. (jbc.org)
Heat shock p1
  • Proteomics 4:1052В-1059 Palmer G, Louvion JF, Tibbetts RS, Engman DM, Picard D (1995) Trypanosoma cruzi heat-shock protein 90 can functionally round out yeast. (daubnet.com)
Increases1
  • CREB increases the growth and survival of immature blood cells resulting in AML. (bearnecessities.org)
Calmodulin1
  • The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. (nih.gov)
Kinases1
  • CHIR-99021 is a GSK-3α/β inhibitor with an IC50 of 10 and 6.7 nM，showing 500-fold selectivity over its closest homologs CDC2 and ERK2, as well as other protein kinases. (dcchemicals.com)
Repressor1
  • The researchers found that HDAC2, but not HDAC1, binds to this co-repressor. (alzforum.org)
Enhances1
  • These data indicate that Tax does not regulate DNA binding of CREB by altering dimerization, but rather enhances DNA binding by additionally interacting with the minor groove of flanking DNA sequences. (elsevier.com)