A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Dysprosium. An element of the rare earth family that has the atomic symbol Dy, atomic number 66, and atomic weight 162.50. Dysprosium is a silvery metal used primarily in the form of various salts.
An isoenzyme of creatine kinase found in the MUSCLE.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
A form of creatine kinase found in the BRAIN.
A form of creatine kinase found in the MITOCHONDRIA.
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.
An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC
Contractile tissue that produces movement in animals.
Agents that inhibit PROTEIN KINASES.
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Electrophoresis in which cellulose acetate is the diffusion medium.
The rate dynamics in chemical or physical systems.
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.
A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.
Elements of limited time intervals, contributing to particular results or situations.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. EC 2.1.4.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. (1/79)

The primary aim of this study was to relate molecular and structural properties of in vitro reconstructed cardiac muscle with its electrophysiological function using an in vitro model system based on neonatal rat cardiac myocytes, three-dimensional polymeric scaffolds, and bioreactors. After 1 wk of cultivation, we found that engineered cardiac muscle contained a 120- to 160-microm-thick peripheral region with cardiac myocytes that were electrically connected through gap junctions and sustained macroscopically continuous impulse propagation over a distance of 5 mm. Molecular, structural, and electrophysiological properties were found to be interrelated and depended on specific model system parameters such as the tissue culture substrate, bioreactor, and culture medium. Native tissue and the best experimental group (engineered cardiac muscle cultivated using laminin-coated scaffolds, rotating bioreactors, and low-serum medium) were comparable with respect to the conduction velocity of propagated electrical impulses and spatial distribution of connexin43. Furthermore, the structural and electrophysiological properties of the engineered cardiac muscle, such as cellularity, conduction velocity, maximum signal amplitude, capture rate, and excitation threshold, were significantly improved compared with our previous studies.  (+info)

Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure. (2/79)

OBJECTIVE: Oxidative stress is implicated in the initiation and progression of congestive heart failure, but the putative reactive species and cellular targets involved remain undefined. We have previously shown that peroxynitrite (ONOO(-), an aggressive biological oxidant and nitrating agent) potently inhibits myofibrillar creatine kinase (MM-CK), a critical controller of contractility known to be impaired during heart failure. Here we hypothesized that nitration and inhibition of MM-CK participate in cardiac failure in vivo. METHODS: Heart failure was induced in rats by myocardial infarction (left coronary artery ligation) and confirmed by histological analysis at 8 weeks postinfarct (1.3+/-1.4 vs. 37.7+/-3.2% left ventricular circumference; sham control vs. CHF, n=10 each). RESULTS: Immunohistochemistry demonstrated significantly increased protein nitration in failing myocardium compared to control (optical density: 0.58+/-0.06 vs. 0.93+/-0.09, sham vs. CHF, P<0.05). Significant decreases in MM-CK activity and content were observed in failing hearts (MM-CK k(cat): 6.0+/-0.4 vs. 3.0+/-0.3 micromol/nM M-CK/min, P<0.05; 6.8+/-1.3 vs. 4.7+/-1.2% myofibrillar protein, P<0.05), with no change in myosin ATPase activity. In separate experiments, isolated rat cardiac myofibrils were exposed to ONOO(-) (2-250 microM) and enzyme studies were conducted. Identical to in vivo studies, selective reductions in MM-CK were observed at ONOO(-) concentrations as low as 2 microM (IC(50)=92.5+/-6.0 microM); myosin ATPase was unaffected with ONOO(-) concentrations as high as 250 microM. Concentration dependent nitration of MM-CK occurred and extent of nitration was statistically correlated to extent of CK inhibition (P<0.001). Immunoprecipitation of MM-CK from failing left ventricle yielded significant evidence of tyrosine nitration. CONCLUSION: These data demonstrate that cardiac ONOO(-) formation and perturbation of myofibrillar energetic controllers occur during experimental heart failure; MM-CK may be a critical cellular target in this setting.  (+info)

Production of recombinant human creatine kinase (r-hCK) isozymes by tandem repeat expression of M and B genes and characterization of r-hCK-MB. (3/79)

BACKGROUND: Serum creatine kinase-MB isoenzyme (CK-MB) is widely used as a marker of myocardial injury. We prepared recombinant human CK (r-hCK) MB isoenzyme and examined its potential for use as a control material for assay of CK-MB in serum. METHODS: cDNAs encoding CK-M and CK-B subunits were inserted into the same plasmid vector, followed by transformation of Escherichia coli. The resulting three types of CK isoenzymes were purified by conventional chromatography. RESULTS: The ratio of MB to MM to BB was 50:40:10 on the basis of CK activity. Highly purified CK-MB with a specific activity of 533 U/mg was produced in a yield of 5.7 mg/g of packed cells. Purified r-hCK-MB had the isoelectric point (pI 5.3) and molecular size (46 kDa for the subunit) of native CK-MB. Its immunoreactivity in an ELISA using antibody against native heart enzyme was similar to that of cardiac CK-MB. The r-hCK-MB retained >90% activity for at least 4 months at 11 degrees C in a delipidated serum matrix in a liquid form at a concentration of 118 U/L. CONCLUSIONS: r-hCK-MB shows key properties of the native cardiac isoenzyme and may be useful as a control and calibrator for serum assays of CK-MB.  (+info)

Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. (4/79)

Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the alpha 7 beta 1 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), alpha 2 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and alpha 7 integrin congenital muscular dystrophy. Therefore, the molecular continuity between the extracellular matrix and cell cytoskeleton is essential for the structural and functional integrity of skeletal muscle. To test whether the alpha 7 beta 1 integrin can compensate for the absence of dystrophin, we expressed the rat alpha 7 chain in mdx/utr(-/-) mice that lack both dystrophin and utrophin. These mice develop a severe muscular dystrophy highly akin to that in DMD, and they also die prematurely. Using the muscle creatine kinase promoter, expression of the alpha 7BX2 integrin chain was increased 2.0-2.3-fold in mdx/utr(-/-) mice. Concomitant with the increase in the alpha 7 chain, its heterodimeric partner, beta 1D, was also increased in the transgenic animals. Transgenic expression of the alpha 7BX2 chain in the mdx/utr(-/-) mice extended their longevity by threefold, reduced kyphosis and the development of muscle disease, and maintained mobility and the structure of the neuromuscular junction. Thus, bolstering alpha 7 beta 1 integrin-mediated association of muscle cells with the extracellular matrix alleviates many of the symptoms of disease observed in mdx/utr(-/-) mice and compensates for the absence of the dystrophin- and utrophin-mediated linkage systems. This suggests that enhanced expression of the alpha 7 beta 1 integrin may provide a novel approach to treat DMD and other muscle diseases that arise due to defects in the dystrophin glycoprotein complex. A video that contrasts kyphosis, gait, joint contractures, and mobility in mdx/utr(-/-) and alpha 7BX2-mdx/utr(-/-) mice can be accessed at http://www.jcb.org/cgi/content/full/152/6/1207.  (+info)

Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle. (5/79)

Significant levels of adenovirus (Ad)-mediated gene transfer occur only in immature muscle or in regenerating muscle, indicating that a developmentally regulated event plays a major role in limiting transgene expression in mature skeletal muscle. We have previously shown that in developing mouse muscle, expression of the primary Ad receptor CAR is severely downregulated during muscle maturation. To evaluate how global expression of CAR throughout muscle affects Ad vector (AdV)-mediated gene transfer into mature skeletal muscle, we produced transgenic mice that express the CAR cDNA under the control of the muscle-specific creatine kinase promoter. Five-month-old transgenic mice were compared to their nontransgenic littermates for their susceptibility to AdV transduction. In CAR transgenics that had been injected in the tibialis anterior muscle with AdVCMVlacZ, increased gene transfer was demonstrated by the increase in the number of transduced muscle fibers (433 +/- 121 in transgenic mice versus 8 +/- 4 in nontransgenic littermates) as well as the 25-fold increase in overall beta-galactosidase activity. Even when the reporter gene was driven by a more efficient promoter (the cytomegalovirus enhancer-chicken beta-actin gene promoter), differential transducibility was still evident (893 +/- 149 versus 153 +/- 30 fibers; P < 0.001). Furthermore, a fivefold decrease in the titer of injected AdV still resulted in significant transduction of muscle (253 +/- 130 versus 14 +/- 4 fibers). The dramatic enhancement in AdV-mediated gene transfer to mature skeletal muscle that is observed in the CAR transgenics indicates that prior modulation of the level of CAR expression can overcome the poor AdV transducibility of mature skeletal muscle and significant transduction can be obtained at low titers of AdV.  (+info)

Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. (6/79)

Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents, but it is not known whether these alterations contribute to the pathogenesis of insulin resistance. To address this question, we generated transgenic mice that overexpress human LAR, specifically in muscle, to levels comparable to those reported in insulin-resistant humans. In LAR-transgenic mice, fasting plasma insulin was increased 2.5-fold compared with wild-type controls, whereas fasting glucose was normal. Whole-body glucose disposal and glucose uptake into muscle in vivo were reduced by 39-50%. Insulin injection resulted in normal tyrosyl phosphorylation of the insulin receptor and insulin receptor substrate 1 (IRS-1) in muscle of transgenic mice. However, phosphorylation of IRS-2 was reduced by 62%, PI3' kinase activity associated with phosphotyrosine, IRS-1, or IRS-2 was reduced by 34-57%, and association of p85alpha with both IRS proteins was reduced by 39-52%. Thus, overexpression of LAR in muscle causes whole-body insulin resistance, most likely due to dephosphorylation of specific regulatory phosphotyrosines on IRS proteins. Our data suggest that increased expression and/or activity of LAR or related PTPs in insulin target tissues of obese humans may contribute to the pathogenesis of insulin resistance.  (+info)

Screening of dystrophin gene deletions in Egyptian patients with DMD/BMD muscular dystrophies. (7/79)

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are allelic disorders caused by mutations within the dystrophin gene. Our study has identified 100 Egyptian families collected from the Human Genetics Clinic, National Research Center, Cairo. All cases were subjected to complete clinical evaluation pedigree analysis, electromyography studies, estimation of serum creatine phosphokinase enzyme (CPK) levels and DNA analysis. Multiplex PCR using 18 pairs of specific primers were used for screening of deletion mutations within the dystrophin gene. A frequency of 55% among the families. Sixty per cent of detected deletions involved multiple exons spanning the major or the minor hot spot of the dystrophin gene. The remainder 40% which mainly involved exon 45. Comparing these findings with frequencies of other countries it was found that our figures fall within the reported range of 40%- distribution of deletions in our study and other different studies was variable and specific ethnic differences do not apparently account for specific deletions. In addition this study concluded that employment of the 18 exon analysis is a cost effective and a highly accurate (97% to launch a nationwide program.  (+info)

Electrophoresis of creatine kinase isoforms: a highly sensitive fluorescence scanning method. (8/79)

OBJECTIVE: To develop an agarose electrophoretic method for creatine kinase (CK) isoforms, using highly sensitive fluorescence scanning. METHODS: A discontinuous buffer system was used. Electrophoresis on agarose gel was performed under constant current and low voltage. CK isoforms were separated within 30 minutes and detected by fluorescence scanning. RESULTS: There were no significant differences when the activities of CK-MM were between 853.0 U/L and 14.0 U/L and those of CK-MB between 152.0 U/L and 2.4 U/L. The detection limits of stain method for CK-MM and CK-MB isoforms were 36.0 U/L and 12.3 U/L, respectively; while those of fluorescence method were 12.0 U/L and 2.1 U/L. The experimental results showed good precision for CK-MM isoforms, as well for CK-MB isoforms and isoenzymes. CONCLUSION: An agarose electrophoretic method has been developed to measure CK isoenzymes and isoforms clinically. This method is rapid, simple, sensitive, highly reproducible and inexpensive. It is suitable for general laboratories.  (+info)

Rhabdomyolysis can be caused by a variety of factors, including:

1. Physical trauma or injury to the muscles
2. Overuse or strain of muscles
3. Poor physical conditioning or training
4. Infections such as viral or bacterial infections that affect the muscles
5. Certain medications or drugs, such as statins and antibiotics
6. Alcohol or drug poisoning
7. Heat stroke or other forms of extreme heat exposure
8. Hypothyroidism (underactive thyroid)
9. Genetic disorders that affect muscle function.

Symptoms of rhabdomyolysis can include:

1. Muscle weakness or paralysis
2. Muscle pain or cramping
3. Confusion or disorientation
4. Dark urine or decreased urine output
5. Fever, nausea, and vomiting
6. Shortness of breath or difficulty breathing
7. Abnormal heart rhythms or cardiac arrest.

If you suspect that someone has rhabdomyolysis, it is important to seek medical attention immediately. Treatment typically involves supportive care, such as fluids and electrolyte replacement, as well as addressing any underlying causes of the condition. In severe cases, hospitalization may be necessary to monitor and treat complications such as kidney failure or cardiac problems.

1. Muscular dystrophy: A group of genetic disorders characterized by progressive muscle weakness and degeneration.
2. Myopathy: A condition where the muscles become damaged or diseased, leading to muscle weakness and wasting.
3. Fibromyalgia: A chronic condition characterized by widespread pain, fatigue, and muscle stiffness.
4. Rhabdomyolysis: A condition where the muscle tissue is damaged, leading to the release of myoglobin into the bloodstream and potentially causing kidney damage.
5. Polymyositis/dermatomyositis: Inflammatory conditions that affect the muscles and skin.
6. Muscle strain: A common injury caused by overstretching or tearing of muscle fibers.
7. Cervical dystonia: A movement disorder characterized by involuntary contractions of the neck muscles.
8. Myasthenia gravis: An autoimmune disorder that affects the nerve-muscle connection, leading to muscle weakness and fatigue.
9. Oculopharyngeal myopathy: A condition characterized by weakness of the muscles used for swallowing and eye movements.
10. Inclusion body myositis: An inflammatory condition that affects the muscles, leading to progressive muscle weakness and wasting.

These are just a few examples of the many different types of muscular diseases that can affect individuals. Each condition has its unique set of symptoms, causes, and treatment options. It's important for individuals experiencing muscle weakness or wasting to seek medical attention to receive an accurate diagnosis and appropriate care.

Cytosolic BB-CK, as well as muscle-type MM-CK both form banana-shaped symmetric dimers, with one catalytic active site in each ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ... Thus creatine kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC expressed ...
Creatine+Kinase,+MM+Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKM genome location and ... "The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase". J. Biol. Chem. 282 ... Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene. In the figure to the ... 2007). "CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise". J. Appl. Physiol. ...
Creatine kinase (CK) test: measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), brain ... Various forms of family-based treatment have been proven to work in the treatment of adolescent AN including conjoint family ... Halmi KA, Tozzi F, Thornton LM, Crow S, Fichter MM, Kaplan AS, et al. (December 2005). "The relation among perfectionism, ... The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which the person loses a significant amount of weight and ...
... itself can be phosphorylated by creatine kinase to form phosphocreatine, which is used as an energy buffer in skeletal ... The phosphate group is attached to an NH center of the creatine. In skeletal muscle, PCr concentrations may reach 20-35 mM or ... A cyclic form of creatine, called creatinine, exists in equilibrium with its tautomer and with creatine. Creatine is ... Persky AM, Rawson ES (2007). "Safety of creatine supplementation". Creatine and Creatine Kinase in Health and Disease. ...
Latham J, Campbell D, Nichols W, Mott T (2008). "How much can exercise raise creatine kinase level-and does it matter?". The ... Use of high-potency neuroleptics, a rapid increase in the dosage of neuroleptics, and use of long-acting forms of neuroleptics ... Dhib-Jalbut S, Hesselbrock R, Mouradian MM, Means ED (1987). "Bromocriptine treatment of neuroleptic malignant syndrome". The ... The raised white blood cell count and creatine phosphokinase (CPK) plasma concentration seen in those with NMS is due to ...
Creatine kinase (CPK-MM) levels in the bloodstream are extremely high. An electromyography (EMG) shows that weakness is caused ... Form-fitting removable leg braces that hold the ankle in place during sleep can defer the onset of contractures. Appropriate ... Those affected also have a high level of creatine kinase in their blood. Although there is no known cure, physical therapy, ... People with Becker's muscular dystrophy, which is milder than DMD, have a form of dystrophin which is functional even though it ...
Tests can be run to check creatine kinase in the blood, which is often normal or mildly elevated in congenital myopathies. ... In its severest form, affected babies often die from respiratory failure. To date, 9 gene mutations have been found to cause ... Ryan MM, Schnell C, Strickland CD, et al. (September 2001). "Nemaline myopathy: a clinical study of 143 cases". Annals of ... Diagnosis usually relies on this method, as creatine kinase levels and electromyography can be unreliable and non-specific. ...
Elevated creatine kinase (CK) levels in the blood (at most ~10 times normal) are typical in sIBM but affected individuals can ... Since these forms do not show features of muscle inflammation, they are classified as myopathies rather than forms of myositis ... Machado, P; Dimachkie, MM; Bahron, RJ (October 2014). "Sporadic Inclusion Body Myositis: new insights and potential therapy". ... Moghadam-Kia, Siamak; Oddis, Chester V.; Aggarwal, Rohit (2016). "Approach to asymptomatic creatine kinase elevation". ...
... releasing intracellular muscle content into the blood as reflected by elevated blood levels of creatine kinase. Exercise ... 200 mm Hg or resting diastolic blood pressure >110 mm Hg Severe pulmonary hypertension Chronic fatigue syndrome Suspected or ... Chronic pain that makes a person unwilling to undertake a physical activity is not, by itself, a form of exercise intolerance. ...
Creatine conversion to phosphocreatine is catalyzed by creatine kinase; spontaneous formation of creatinine occurs during the ... In chemical terms, creatinine is a lactam and an imidazolidinone, so a spontaneously formed cyclic derivative of creatine. ... Lewis SL, Bucher L, Heitkemper MM, Harding MM, Kwong J, Roberts D (September 2016). Medical-surgical nursing : assessment and ... Leland KM, McDonald TL, Drescher KM (September 2011). "Effect of creatine, creatinine, and creatine ethyl ester on TLR ...
ISBN 978-0-444-88232-5. Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange ... Firstly, CK- MM was eluted, then CK-MB, followed by CK-BB. Therefore, the isoenzymes found in each sample could be used to ... This competition led to fast growth of new forms and the fast evolution of IC. A challenge that needs to be overcome in the ... Therefore, IC has been employed in drugs in the form of tablets and capsules in order to determine the amount of drug dissolve ...
substrate pages: glycerol 3-phosphate, dihydroxyacetone phosphate related topics: glycerol phosphate shuttle, creatine kinase, ... White MR, Khan MM, Deredge D, Ross CR, Quintyn R, Zucconi BE, Wysocki VH, Wintrode PL, Wilson GM, Garcin ED (Jan 2015). "A ... As a result, there is a tendency to form adipose tissue leading to an accumulation of fat that favors obesity. GPDH has also ... The reactions catalyzed by cytosolic (soluble) and mitochondrial GPDH are as follows: There are two forms of GPDH: The ...
... include muscle pain and weakness in the presence of an elevated creatine kinase (CK). King brown snake venom has some ... If the smoke resembled the mali, or immaterial form, of a snake, then the person would die, as the victim of a ragalk (sorcerer ... The incubating temperature has been recorded as between 22 and 32 °C (72 and 90 °F). The eggs average 40.1 mm (1+5⁄8 in) in ... Clade II corresponded to a lineage of large snakes found across Australia, clade III was a dwarf form from the Kimberley, and ...
... creatine kinase, mitochondrial form MeSH D08.811.913.696.640.150.875 - creatine kinase, mm form MeSH D08.811.913.696.645 - ... creatine kinase MeSH D08.811.913.696.640.150.500 - creatine kinase, bb form MeSH D08.811.913.696.640.150.625 - creatine kinase ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ...
Adult patients often have serum and/or urine screen positive for the presence of myoglobin and serum creatine kinase and ... Severe forms may have continual pain from general life activity. The adult form has a variable age of onset. The first ... Nelson DL and Cox MM (2005). "Fatty Acid Catabolism" in Lehninger Principles of Biochemistry, 4th Ed. New York: W.H. Freeman ... This is noteworthy in light of the fact that this mutation is associated with the exercise-induced adult form (i.e., rising ...
Liver enzymes Creatine kinase (and CK-MB fraction in many hospitals) D-dimer (when suspicion for pulmonary embolism is present ... Wertli MM, Ruchti KB, Steurer J, Held U (November 2013). "Diagnostic indicators of non-cardiovascular chest pain: a systematic ... Another benign and harmless form of a sharp, localized chest pain often mistaken for heart disease. Breast conditions Herpes ... Burgstaller JM, Jenni BF, Steurer J, Held U, Wertli MM (2014-08-11). "Treatment efficacy for non-cardiovascular chest pain: a ...
Cheng HS, Chua SO, Hung JS, Yip KK (April 1991). "Creatine kinase MB elevation in paralytic shellfish poisoning". Chest. 99 (4 ... Nav channels form the basis for electrical excitability in animals. Nav channels evolved from Ca2+ channels and were present in ... Zhang MM, Gruszczynski P, Walewska A, Bulaj G, Olivera BM, Yoshikami D (July 2010). "Cooccupancy of the outer vestibule of ... other forms of aquatic animal life other than birds or mammals, and all mollusks; and incorporate the use of "ppm" as another ...
Creatine kinase (CK) blood level is often ordered when muscle damage is suspected. CK is an enzyme found in muscle, leaking ... Another form of operative scapular fixation is scapulopexy. "Scapulo-" refers to the scapula bone, and "-pexy" is derived from ... Bergsma, A; Cup, EH; Janssen, MM; Geurts, AC; de Groot, IJ (February 2017). "Upper limb function and activity in people with ... Casein kinase 1 (CK1) inhibition has been identified by Facio Therapies, a Dutch pharmaceutical company, to repress DUX4 ...
... is produced in inactive form as chymotrypsinogen in the pancreas and transported in this form to the stomach where it is ... Cox MM, Nelson DL (2013). "Chapter 6.2: How enzymes work". Lehninger Principles of Biochemistry (6th ed.). New York, N.Y.: W.H ... This is frequently seen in the main enzyme classes such as kinases. Artificial (in vitro) evolution is now commonly used to ... One example of an enzyme that has changed its activity is the ancestor of methionyl amino peptidase (MAP) and creatine ...
Commonly used blood tests include troponin and less often creatine kinase MB. Treatment of an MI is time-critical. Aspirin is ... 2 mm (0,2 mV) for males or ≥1.5 mm (0.15 mV) for females or ≥1 mm (0.1 mV) in two other adjacent chest or limb leads. ST ... A collagen scar forms in their place. When an artery is blocked, cells lack oxygen, needed to produce ATP in mitochondria. ATP ... A cholesterol core forms as foam cells die. In response to growth factors secreted by macrophages, smooth muscle and other ...
Markers of myocardial damage (troponin or creatine kinase cardiac isoenzymes) are elevated. The CRP and ESR are sometimes ... in the form of glucocorticoids with or without azathioprine and cyclosporine. Some of these immune mediated forms of ... Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Colvin MM, et al. (August 2017). "2017 ACC/AHA/HFSA Focused Update of the ... Electric shock Hyperpyrexia, and radiation Most forms of myocarditis involve the infiltration of heart tissues by one or two ...
... creatine kinase increase, metabolic acidosis and hematuria. The patient received 5 ampoules of serum, but the condition ... The documentation and specimen provided indicate a fish that was 133.5 mm in length and had a head with a diameter of 11.5 mm. ... The spots on the head and neck are generally solid, as are those on the tail, where they may merge to form a band. Jaguars ... these spiders grow 30-50 mm in length and 150 mm in wingspan, and are characterized by their aggressive behavior, in the 1970s ...
Khan HA, Alhomida AS, Sobki SH, Moghairi AA, Koronki HE (2012). "Blood cell counts and their correlation with creatine kinase ... They form an essential part of the innate immune system, with their functions varying in different animals. They are formed ... Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, et al. (April 2007). "Platelet TLR4 activates neutrophil ... Trapping of bacteria may be a particularly important role for NETs in sepsis, where NETs are formed within blood vessels. ...
In a similar mechanism, the pro-apoptotic creatine kinase binds and opens VDAC in the absence of HK2. An alternative model ... Lehto M, Xiang K, Stoffel M, Espinosa R, Groop LC, Le Beau MM, Bell GI (Dec 1993). "Human hexokinase II: localization of the ... This gene encodes a 100-kDa, 917-residue enzyme with highly similar N- and C-terminal domains that each form half of the ... As an isoform of hexokinase and a member of the sugar kinase family, HK2 catalyzes the rate-limiting and first obligatory step ...
Perfect MM, Archbold K, Goodwin JL, Levine-Donnerstein D, Quan SF (April 2013). "Risk of behavioral and adaptive functioning ... It is possible that aberrant immune activity during critical periods of neurodevelopment is part of the mechanism of some forms ... glycine amidinotransferase deficiency Guanidinoacetate methyltransferase deficiency X-linked creatine transporter defect 6-N- ... Homocystinuria Branched-chain ketoacid dehydrogenase kinase deficiency Succinic semialdehyde dehydrogenase deficiency Smith- ...
Protein kinase B (Akt) is thought to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. Akt itself is ... Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable ... Chan MM, Adapala N, Chen C (2012). "Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in ... both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular stress. Fasting can ...
... it triggers transporter phosphorylation via protein kinase A (PKA) and protein kinase C (PKC) signaling, ultimately resulting ... The latter is no longer produced and is a gradual-release form of the drug, flattening the curve of the effect of the drug ... Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, ... creatine (Sekine et al., 2002) and increases in a marker of glial activation, myoinositol (Chang et al., 2002; Ernst et al., ...
This altered form, called mutant huntingtin (mHtt), increases the decay rate of certain types of neurons. Regions of the brain ... Kordasiewicz HB, Stanek LM, Wancewicz EV, Mazur C, McAlonis MM, Pytel KA, Artates JW, Weiss A, Cheng SH, Shihabuddin LS, Hung G ... These include chorea acanthocytosis and pantothenate kinase-associated neurodegeneration. One X-linked disorder of this type is ... creatine, minocycline, ethyl-EPA, phenylbutyrate and dimebon. Medicine portal Dayalu P, Albin RL (February 2015). "Huntington ...
Snel J, Lorist MM (2011). "Effects of caffeine on sleep and cognition". Human Sleep and Cognition Part II - Clinical and ... A use of caffeine in this form is said to improve mental alertness. These tablets are commonly used by students studying for ... Tarnopolsky MA (2010). "Caffeine and creatine use in sport". Annals of Nutrition & Metabolism. 57 (Suppl 2): 1-8. doi:10.1159/ ... As a competitive nonselective phosphodiesterase inhibitor, caffeine raises intracellular cyclic AMP, activates protein kinase A ...
MM Form Creatine Kinase Medicine & Life Sciences 100% * Creatine Chemical Compounds 85% ... and of mitochondrial creatine kinase were studied in saponin-skinned fibers taken from normal and M-creatine kinase-deficient ... and of mitochondrial creatine kinase were studied in saponin-skinned fibers taken from normal and M-creatine kinase-deficient ... and of mitochondrial creatine kinase were studied in saponin-skinned fibers taken from normal and M-creatine kinase-deficient ...
MM Form Entry term(s). Creatine Kinase, M Creatine Kinase, MM Creatine Kinase, Muscle Kinase, M Creatine Kinase, MM Creatine ... Kinase, M Creatine. Kinase, MM Creatine. Kinase, Muscle Creatine. M Creatine Kinase. MM Creatine Kinase. Muscle Creatine Kinase ... MM Creatine Kinase Entry term(s):. Creatine Kinase, M. Creatine Kinase, MM. Creatine Kinase, Muscle. ... Kinase, Muscle Creatine M Creatine Kinase MM Creatine Kinase Muscle Creatine Kinase ...
Creatine Kinase (CPK) - is an enzyme found in the brain, heart, skeletal muscle, and other tissues. Enzymes such as creatine ... There are three different forms of CK in your body, referred to as isoenzymes: CK-MB (found mostly in your heart); CK-MM ( ... kinase are proteins that help cells to perform their normal functions. Most of this energy in heart and muscle cells is used ...
For cell function experiments, cell proliferation; the contents of creatine kinase (CK), lactate dehydrogenase (LDH), ... METHODS: H9c2 cells were incubated with H2O2 (final concentration of 1 mM) and then intervened with donepezil at doses of 2.5 ... Hence, we hypothesized that PON2 and its polymorphic forms may be hydrolyzing the AChEIs differently, and thus, different ... OBJECTIVE: Necroptosis, as a form of regulated cell necrosis, could participate in myocardial oxidative damage. We investigated ...
M Creatine Kinase use Creatine Kinase, MM Form m Dihydroxybenzenes use Resorcinols ...
An in vitro kinase assay was performed to assess the phosphorylation activities of a novel CaMK-like protein in T. gondii by ... However, calmodulin antagonists had no effect on its kinase activity. In T. gondii-infected cells, TgCaMKrk localized to the ... We identified a novel CaMK homolog in T. gondii, T. gondii CaMK-related kinase (TgCaMKrk), which exhibits calmodulin- ... Our data improve our understanding of T. gondii motility and infection, the interaction between parasite protein kinases and ...
I also determined the difference between the amino acid composition of Mit-CK and the isoenzyme form (MM-form) of the enzyme. ... I extracted and purified mitochondrial Creatine Kinase (CK). I also determined the mode of interaction between mitochondrial CK ... which is also published by Lambert Publishing Academy Germany in book form. Actually I want to work on the same topic but I ... Mit-CK) and the mitochondrial membrane, and the kinetic parameters of bound and unbound forms of the enzyme. ...
Laboratory results, including creatine kinase, were normal except for an increased erythrocyte sedimentation rate of 60 mm. CSF ... The nerve biopsy showed inflammatory infiltrates predominantly with endoneurial compound formed by CD45 and CD68. The patient ... A sural nerve biopsy showed an inflammatory infiltrate, predominantly endoneurial, formed mainly by CD45 leucocytes and CD68; ...
Creatine kinase isoenzyme (IU/L)§. Phosphocreatine kinase (IU/L)¶. Hospitalized. Outcome. A. 45. Numbness, vomiting, heart ... All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of ... Dhesi P, Ng R, Shehata MM, Shah PK. Ventricular tachycardia after ingestion of ayurveda herbal antidiarrheal medication ... Other indicators of myocardial damage included abnormal levels of creatine kinase isoenzyme and phosphocreatine kinase. The ...
M Creatine Kinase use Creatine Kinase, MM Form m Dihydroxybenzenes use Resorcinols ...
... isoenzymes test measures the different forms of CPK in the blood. CPK is an enzyme found mainly in the heart, brain, and ... Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes; Heart attack - CPK; Crush - CPK ... CPK-3 (also called CPK-MM) is found mostly in skeletal muscle ... The creatine phosphokinase (CPK) isoenzymes test measures the ... different forms of CPK in the blood. CPK is an enzyme found mainly in the heart, brain, and skeletal muscle. ...
Cardiospecific isoenzyme CK-MB (creatine kinase myocardial band), and cardiospecific proteins troponin T and troponin I are ... ST-segment elevation must be greater than 2 mm in chest leads (v1 - v6) or greater than 1 mm in limb leads (I, II, III, aVL and ... Triglycerides-another form of fat in your blood. If it is not possible to get a lipoprotein profile done, knowing your total ... Most of the cholesterol in the blood is the LDL form. The higher the level of LDL cholesterol in the blood, the greater your ...
... reference materials spiked with varying levels of creatine kinase MM isoform (CK-MM). These DBS were evaluated over a 3-week ... Search Form Controls. Search The CDC. submit. CDC A-Z Index Note: Javascript is disabled or is not supported by your browser. ... Multi-laboratory evaluation of prototype dried blood spot quality control materials for creatine kinase-MM newborn screening ... Results from each laboratory were highly correlated with the relative proportion of CK-MM added to each of the six spiked pools ...
... in 100 mM ammonium bicarbonate (eluent for LC-MS, Sigma-Aldrich), 2 mM calcium chloride (anhydrous, free-flowing, Redi-Dri3 97 ... Moreover, in contrast to the other 14-3-3 epitopes, 14-3-3-γ did not form extracellular deposits in our analysis. The chaperone ... Compartmentation of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in neurons: evidence for a creatine ... 2006). The creatine kinase/creatine connection to Alzheimers disease: CK-inactivation, APP-CK complexes and focal creatine ...
Smoke-the vaporous colloidal system formed when a material undergoes combustion or pyrolysis-comprises a collection of noxious ... Patients with large cutaneous burns, crush injuries, or prolonged immobilization should have their serum creatine kinase (CK) ... This value, usually less than 5-10 mm Hg, may be several hundred mm Hg in the setting of significant pulmonary injury and can ... which detect oxygenated and deoxygenated hemoglobin only and not any other form of hemoglobin. Readings are falsely elevated by ...
A retrospective study suggested that even in the absence of myalgias or creatine kinase elevation, a muscle biopsy can aid in ... Boomsma MM, Stegeman CA, van der Leij MJ, et al. Prediction of relapses in Wegeners granulomatosis by measurement of ... He was diagnosed with the limited form of granulomatosis with polyangiitis. View Media Gallery ... Schlieben DJ, Korbet SM, Kimura RE, Schwartz MM, Lewis EJ. Pulmonary-renal syndrome in a newborn with placental transmission of ...
... and they exist in liquid form at room temperature. ... Inhibition of creatine kinase activity by ethylene oxide. Br J ... Jovanic JM, Jovanovich MM, Spasic MJ. Peripheral nerve conduction study in workers exposed to a mixture of organic solvents in ... Ruijten MW, Sallé HJ, Verberk MM. Verification of effects on the nervous system of low level occupational exposure to CS2. Br J ...
Rhabdomyolysis with elevated creatine kinase and renal failure are frequent secondary features. Overall mortality has been ... Pcap is roughly 35 mm Hg at the arterial finish of the capillaries and roughly 15 mm Hg on the venous end. The tight junctions ... If the omega-3 fat is delivered in the 18 carbon -linolenic acid form (canola oil or flaxseed oil), it often has little effect ... At low move, erythrocytes lose their axial place within the stream of blood, lose their ellipsoidal shape, form aggregates, and ...
35 +/- 4% of area at risk, P < 0.01). The cardioprotection was confirmed by significantly lower plasma creatine kinase ... In the controls, the beta cell was most sensitive to an increase in glucose at concentrations between 5.5 and 6.0 mM, whereas ... MIP-1 alpha was higher in RA SF (mean, 29 +/- 8 ng/ml [SE]) compared with other forms of arthritis (2.8 +/- 1.7), or ... kinase kinase and MAP kinase. However, IGF-I is a potent stimulator of directed migration of human arterial SMC, as measured in ...
Her creatine kinase level is within the reference range. Her antinuclear antibody (ANA) titer is 1:160 (low-positive range = 1: ... Her erythrocyte sedimentation rate (ESR) is 26 mm/h (reference range = 0-20 mm/h). Her C-reactive protein (CRP) level is 0.5 mg ... Help us make reference on Medscape the best clinical resource possible. Please use this form to submit your questions or ... Pleasedo not use this form to submit personal or patient medical information or to report adverse drug events. You are ...
Under control conditions, cell fusion and creatine kinase (CK) activity increased in parallel and peaked at 4-6 days. WEF ... The PVA-SNP-cur and PVA-SNP-ba films showed high antioxidant activity of 15.9 and 14.7 Mm/g TEAC, respectively. The described ... A second fluorescently labeled antibody is then added, forming a "sandwich" with the analyte and the capture protein. An ... The PK3 kinase, which integrates SLS signals, is modified by phosphorylation on multiple sites. To determine which of the ...
20 K2-creatine phosphate, and phosphocreatine kinase (50 U/ml). Currents were recorded with pClamp software for Windows ( ... Columns were eluted with a NaCl2 step gradient of 30 ml each of 200, 400, 600, and 800 mm and 1 m NaCl2 in 20 mm HEPES, 1 mm ... The number of synapses formed by RGCs cultured from NP1/2 KO mice is normal. A, B, RGC cultured without astrocytes and stained ... Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000) Biochemical interactions of the neuronal pentraxins. J Biol Chem 276:17786 ...
... ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis. Our results showed that EE: (1 ... In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK ( ... cortex with a pneumatic piston with a 6 mm diameter tip at a rate of 4 m/sec, with 1.5 mm of compression. Velocity was measured ... The resultant phosphocreatine acts as the cytosolic transport and storage form of energy and used to regenerate ATP from ...
The muscle creatine kinase level at the end of the overreaching cycle was 7 times higher than the muscle creatine kinase level ... which is why they form the three categories of Anabolic Steroids. This way we are able to easily find and locate the best ... report letrozole assessment public.5 mm), report letrozole assessment public. Among those who reported hearing no more than ... After the initial administration of creatine kinase (CK), the subjects were given 1 to 2 grams/day of creatine monohydrate (DAA ...
... and his creatine kinase (CK) level was markedly elevated (1145 U/L), with normal CK MB fraction and cardiac troponin levels. ... Adnet PJ, Krivosic-Horber RM, Adamantidis MM, Haudecoeur G, Adnet-Bonte CA, Saulnier F, et al. The association between the ... an elevated creatine kinase level and autonomic instability. The syndrome often develops after a sudden increase in dosage of ... His temperature was elevated (38.3°C), and although normotensive (blood pressure 124/84 mm Hg) he had tachycardia (heart rate ...
Researchers asked 7 female volunteers to perform 5 × 20 maximal drop jumps to induce muscle soreness (11). Creatine kinase and ... a form of rock climbing. Weinbruch et al. (55) investigated the effect of different forms of magnesium carbonate on dust ... Moreover, the garments were composed of 75% closed cell neoprene and 25% butyl rubber and were 4.76-mm thick, which is quite ... Results showed only marginal benefits in creatine kinase and muscle soreness when the participants wore compression garments. ...
They may become acutely insulin-deficient the effects of creatine kinase ck is elevated, and the severity and previous quit ... The selection of an x-linked inheritance except in infantile form. Convalescent fecal excretion of urea nitrogen and creatinine ... Head normal initially may be severe and associated st depressions of mm hg, prehypertension systolic blood pressure and ...
  • Other indicators of myocardial damage included abnormal levels of creatine kinase isoenzyme and phosphocreatine kinase. (cdc.gov)
  • The Newborn Screening Quality Assurance Program (NSQAP) at the U.S. Centers for Disease Control and Prevention (CDC) produced a set of seven prototype dried blood spot (DBS) reference materials spiked with varying levels of creatine kinase MM isoform (CK-MM). These DBS were evaluated over a 3-week period by CDC, NYS, and RTI, all using the same CK-MM isoform-specific fluoroimmunoassay. (cdc.gov)
  • Functional properties of in situ mitochondria and of mitochondrial creatine kinase were studied in saponin-skinned fibers taken from normal and M-creatine kinase-deficient mice. (elsevier.com)
  • In mutant fast-twitch muscle, a decrease rather than increase in mitochondrial sensitivity to ADP occurred, but creatine still had no effect. (elsevier.com)
  • I extracted and purified mitochondrial Creatine Kinase (CK). (victorjtemple.com)
  • I also determined the mode of interaction between mitochondrial CK (Mit-CK) and the mitochondrial membrane, and the kinetic parameters of bound and unbound forms of the enzyme. (victorjtemple.com)
  • CKB, which has both a cytosolic and mitochondrial form, is responsible for the transformation of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and thus maintains ATP reserves through phosphocreatine production. (proquest.com)
  • In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK (ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis. (biomedcentral.com)
  • We previously showed that Plasmodium falciparum expresses a homolog of human calcium calmodulin-dependent protein kinase (CaMK) that is important for host cell invasion. (biomedcentral.com)
  • An in vitro kinase assay was performed to assess the phosphorylation activities of a novel CaMK-like protein in T. gondii by using purified proteins with various concentrations of calcium, calmodulin antagonists, or T. gondii glideosome proteins. (biomedcentral.com)
  • Indirect immunofluorescence microscopy was performed to detect the localization of this protein kinase by using the antibodies against this protein and organellar maker proteins of T. gondii . (biomedcentral.com)
  • Our data improve our understanding of T. gondii motility and infection, the interaction between parasite protein kinases and glideosomes, and drug targets for protozoan diseases. (biomedcentral.com)
  • Additional T. gondii protein kinases are involved in host manipulation, cell cycle regulation, and functions required for growth, stress responses, and the transition from tachyzoite to bradyzoite [ 15 ]. (biomedcentral.com)
  • 14-3-3-γ belongs to a highly conserved protein family mainly expressed in the brain where it regulates diverse functions by binding to kinases, signaling proteins, hydroxylases, and about 170 other ligands (Umahara et al. (proquest.com)
  • Complete blood cell count, C-reactive protein (CRP), creatine kinase (CK), lipid peroxidation and antioxidant capacity against peroxyl radicals were previously evaluated (baseline), and at 0, 30 and 120 min. (bvsalud.org)
  • The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl cyclase and sequestration of the receptors away from the cell surface. (jci.org)
  • These measurements showed that a moderate amount of protein, carbohydrates, and some fat consumption were sufficient for the creatine kinase in the blood to increase as compared to that in the overreaching cycle, letrozole assessment report public. (luciasalvi.ca)
  • An isoenzyme of creatine kinase found in the MUSCLE . (bvsalud.org)
  • I also determined the difference between the amino acid composition of Mit-CK and the isoenzyme form (MM-form) of the enzyme. (victorjtemple.com)
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (medlineplus.gov)
  • Isoenzima de la creatina-cinasa que se encuentra en el MÚSCULO. (bvsalud.org)
  • Hemograma completo, proteína C-reativa (PCR), creatina kinase (CK), lipoperoxidação e capacidade antioxidante contra o radical peroxil foram avaliados previamente (basal), 0, 30 e 120 min. (bvsalud.org)
  • Drugs which require thymidine kinase (TK) for activity are ineffective in vitro. (pipoforex.com)
  • CK stands for creatine kinase , an enzyme that leaks out of damaged muscle. (mda.org)
  • Muscle creatine kinase-deficient mice. (elsevier.com)
  • Dive into the research topics of 'Muscle creatine kinase-deficient mice. (elsevier.com)
  • In the overreaching cycle, in contrast, there was no significant change in the muscle creatine kinase level between the fasting and the overreaching cycle, letrozole public assessment report. (luciasalvi.ca)
  • The muscle creatine kinase level at the end of the overreaching cycle was 7 times higher than the muscle creatine kinase level at the beginning of the overreaching cycle in the overreaching cycle group. (luciasalvi.ca)
  • Studies have shown that vegetarians do have marginally lower muscle creatine concentra- tions than those who eat meat and fish (Delanghe et al. (pipoforex.com)
  • We identified a novel CaMK homolog in T. gondii , T. gondii CaMK-related kinase (TgCaMKrk), which exhibits calmodulin-independent autophosphorylation and substrate phosphorylation activity. (biomedcentral.com)
  • Thus, given their level of involvement in many aspects of the parasitic life-cycle, the kinases encoded by the parasite genome are obvious potential drug targets. (biomedcentral.com)
  • 60 mm Hg in room air) or hypercarbia (alveolar [arterial] carbon dioxide pressure [PaCO 2 ] level of 55 mm Hg) indicate significant respiratory insufficiency. (medscape.com)
  • Her creatine kinase level is within the reference range. (medscape.com)
  • The same creatine kinase level was determined at the final week of the overreaching cycle, 2nd round of letrozole success stories. (luciasalvi.ca)
  • When overreaching (n = 20) was carried out in the absence of food (n = 10), there was no change in the creatine kinase level in the overreaching cycle. (luciasalvi.ca)
  • However, after a 4-week fast (n = 10) and after an infusion of 1 g/day of β-alanine plus 1 and 2 g/day of EAAs for 7 days after the fast and 1 and 2 g/day of BIA for the last 4 days of the fasting, creatine kinase level increased in the overreaching cycle by 7%, obat kortikosteroid salep. (luciasalvi.ca)
  • NMS, a rare but potentially fatal complication of neuroleptic medications (e.g., antipsychotics, sedatives and antinauseants), is characterized by hyperthermia, muscle rigidity, an elevated creatine kinase level and autonomic instability. (cmaj.ca)
  • Laboratory investigation revealed mild leukocytosis (leukocyte count 11.7 х 10 9 /L), with a shift to the left (neutrophil count 9.9 х 10 9 /L). His aspartate aminotransferase level was elevated (82 U/L), and his creatine kinase (CK) level was markedly elevated (1145 U/L), with normal CK MB fraction and cardiac troponin levels. (cmaj.ca)
  • The PVA-SNP-cur and PVA-SNP-ba films showed high antioxidant activity of 15.9 and 14.7 Mm/g TEAC, respectively. (articali.app)
  • OBJECTIVE: Necroptosis, as a form of regulated cell necrosis, could participate in myocardial oxidative damage. (bvsalud.org)
  • Abstract This study was carried out to evaluate the effect of Glutamine, as a dipeptide or a free amino acid form, on the progression of burn injuries in rats. (bvsalud.org)
  • 1 to 2 grams of EAAs to induce maximal energy mobilization of the heart, and 0.5 g/day of BIA to produce a dose of creatine in the blood with a plasma to creatinine (Cr), and a peak plasma creatine to Cr ratio of 2 to 15, with a half-life of 6 to 8 hours. (luciasalvi.ca)
  • His temperature was elevated (38.3°C), and although normotensive (blood pressure 124/84 mm Hg) he had tachycardia (heart rate 128 beats/min) and exhibited Parkinsonian features, including tremor, rigidity and unsteady gait. (cmaj.ca)
  • however, no kinase function has been found to be of critical importance in the primary host, felines. (biomedcentral.com)
  • Based on reference ranges established by NYS and RTI for their pilot studies, these contrived DBS collectively spanned the CK-MM ranges found in typical newborns and the elevated ranges associated with DMD. (cdc.gov)
  • However, calmodulin antagonists had no effect on its kinase activity. (biomedcentral.com)
  • Pulse oximetry readings can be misleading in the setting of carbon monoxide (CO) exposure or methemoglobinemia because these devices use only 2 wavelengths of light (the red and the infrared spectrum), which detect oxygenated and deoxygenated hemoglobin only and not any other form of hemoglobin. (medscape.com)
  • Results from each laboratory were highly correlated with the relative proportion of CK-MM added to each of the six spiked pools. (cdc.gov)
  • Xeljanz (tofacitinib) is the first entry into a class of medications called Janus kinase (JAK) inhibitors . (verywellhealth.com)
  • Please contact [email protected] if you need assistance with data entry, if you have any query on the CRF, and to let us know that you are using the forms. (who.int)
  • Her erythrocyte sedimentation rate (ESR) is 26 mm/h (reference range = 0-20 mm/h). (medscape.com)
  • METHODS: H9c2 cells were incubated with H2O2 (final concentration of 1 mM) and then intervened with donepezil at doses of 2.5 and 10 µM. (bvsalud.org)
  • Question 21: Cells from a muscle tumor show a reduced ability to form new muscle and appear highly disorganized. (coursefighter.com)
  • This value, usually less than 5-10 mm Hg, may be several hundred mm Hg in the setting of significant pulmonary injury and can be used to assess improvement or deterioration in lung function when measured at a stable fraction of inspired oxygen (FiO 2 ). (medscape.com)
  • The assessment of creatine kinase (CK), testosterone, and cortisol was carried out at the ninth and tenth weeks during the overreaching cycleand in the final 3 weeks of the overreaching cycle. (luciasalvi.ca)
  • As compared to control, in situ mitochondria in transgenic ventricular and slow- twitch muscles showed two times lower K(m) values for ADP, and the presence of creatine only slightly decreased the K(m) values. (elsevier.com)
  • Please use this form to submit your questions or comments on how to make this article more useful to clinicians. (medscape.com)
  • Please do not use this form to submit personal or patient medical information or to report adverse drug events. (medscape.com)