Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Creatine Kinase, MB Form: An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.Clinical Enzyme Tests: Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Creatine: An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.Creatine Kinase, MM Form: An isoenzyme of creatine kinase found in the MUSCLE.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Myoglobin: A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.Creatine Kinase, BB Form: A form of creatine kinase found in the BRAIN.Creatine Kinase, Mitochondrial Form: A form of creatine kinase found in the MITOCHONDRIA.Technetium Tc 99m Pyrophosphate: A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.L-Lactate Dehydrogenase: A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.Electrophoresis, Agar Gel: Electrophoresis in which agar or agarose gel is used as the diffusion medium.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Troponin: One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Phosphocreatine: An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)MAP Kinase Signaling System: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Protein Kinases: A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Arginine Kinase: An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.Muscles: Contractile tissue that produces movement in animals.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Calcium-Calmodulin-Dependent Protein Kinases: A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.src-Family Kinases: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.Electrophoresis, Cellulose Acetate: Electrophoresis in which cellulose acetate is the diffusion medium.p38 Mitogen-Activated Protein Kinases: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Cyclic AMP-Dependent Protein Kinases: A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.Kinetics: The rate dynamics in chemical or physical systems.Mitogen-Activated Protein Kinase 1: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.Pyruvate Kinase: ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.Adenylate Kinase: An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.p21-Activated Kinases: A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Mitogen-Activated Protein Kinase Kinases: A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Guanidinoacetate N-Methyltransferase: This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.Mitogen-Activated Protein Kinase 3: A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Amidinotransferases: Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. EC 2.1.4.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.CDC2 Protein Kinase: Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Cyclin-Dependent Kinases: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.MAP Kinase Kinase Kinases: Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.eIF-2 Kinase: A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.Casein Kinase II: A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.Casein Kinases: A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.Mitochondria, Heart: The mitochondria of the myocardium.Ribosomal Protein S6 Kinases: A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.MAP Kinase Kinase 1: An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.Myositis: Inflammation of a muscle or muscle tissue.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Aspartate Aminotransferases: Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.Receptor Protein-Tyrosine Kinases: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Extracellular Signal-Regulated MAP Kinases: A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.MAP Kinase Kinase 4: A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.1-Phosphatidylinositol 4-Kinase: An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.Phosphotransferases (Alcohol Group Acceptor): A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).CDC2-CDC28 Kinases: A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE; S CEREVISIAE; and the CDC2 PROTEIN KINASE found in mammalian species.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction. (1/344)

BACKGROUND: Validation of whole blood, point-of-care testing devices for monitoring cardiac markers to aid clinicians in ruling in and ruling out myocardial infarction (MI) is necessary for both laboratory and clinical acceptance. METHODS: This study evaluated the clinical diagnostic sensitivity and specificity of the First Medical Cardiac Test device operated by nursing and laboratory personnel that simultaneously measures cardiac troponin I (cTnI), creatine kinase (CK) MB, myoglobin, and total CK on the Alpha Dx analyzer in whole blood for detection of MI. Over a 6-month period, 369 patients initially presenting to the emergency department with chest pain were evaluated for MI using modified WHO criteria. Eighty-nine patients (24%) were diagnosed with MI. RESULTS: In whole blood samples collected at admission and at 3- to 6-h intervals over 24 h, ROC curve-determined MI decision limits were as follows: cTnI, 0.4 microgram/L; CKMB, 7.0 microgram/L; myoglobin, 180 microgram/L; total CK, 190 microgram/L. Based on peak concentrations within 24 h after presentation, the following sensitivities (+/- 95% confidence intervals) were found: cTnI, 93% +/- 5.5%; myoglobin, 81% +/- 9.7%; CKMB, 90% +/- 6.3%; total CK, 86% +/- 7.5%. Sensitivities were maximal at >90% for both cTnI and CKMB at >12 h in MI patients, without differences between ST-segment elevation and non-ST-segment elevation MI patients. CONCLUSIONS: The First Medical point-of-care device provides cardiac marker assays that can be used by laboratories and clinicians in a variety of hospital settings for ruling in and ruling out MI.  (+info)

Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction. (2/344)

The study of ischemia/reperfusion injury included 25 patients in the acute phase of myocardial infarction (19 perfused, 6 remained non-reperfused as evaluated according to the time course of creatine kinase and CK-MB isoenzyme activity) and a control group (21 blood donors). Plasma level of malondialdehyde was followed as a marker of oxidative stress. Shortly after reperfusion (within 90 min), a transient increase of malondialdehyde concentration was detected. The return to the baseline level was achieved 6 h after the onset of therapy. The activity of a free radical scavenger enzyme, plasma glutathione peroxidase (GPx), reached its maximum 90 min after the onset of treatment and returned to the initial value after 18 h. The specificity of the GPx response was confirmed by comparing with both non-reperfused patients and the control group, where no significant increase was detected. The erythrocyte Cu,Zn-superoxide dismutase (SOD) did not exhibit significant changes during the interval studied in perfused patients, probably due to the stability of erythrocyte metabolism. In non-reperfused patients, a decrease of SOD was found during prolonged hypoxia. These results help to elucidate the mechanisms of fast activation of plasma antioxidant system during the reperfusion after myocardial infarction.  (+info)

Safe discharge from the cardiac emergency room with a rapid rule-out myocardial infarction protocol using serial CK-MB(mass). (3/344)

OBJECTIVE: To determine whether a new protocol, using a rapid and sensitive CK-MB(mass) assay and serial sampling, can rule out myocardial infarction in patients with chest pain and decrease their length of stay in the cardiac emergency room without increasing risk. DESIGN: The combined incidence of cardiac death and acute myocardial infarction at 30 days, six months, and 24 months of follow up were compared between patients discharged home from the cardiac emergency room after ruling out myocardial infarction with a CK-MB(activity) assay in 1994 and those discharged home after a rapid CK-MB(mass) assay in 1996. SETTING: Cardiac emergency room of a large university hospital. PATIENTS: In 1994 and 1996, 230 and 423 chest pain patients, respectively, were discharged home from the cardiac emergency room with a normal CK-MB and an uneventful observation period. RESULTS: The median length of stay in the cardiac emergency room was significantly reduced, from 16.0 hours in 1994 to 9.0 hours in 1996 (p < 0.0001). Mean event rates in patients from the 1994 and 1996 cohorts, respectively, were 0.9% (95% confidence interval (CI) -0.3% to 2.1%) v 0.7% (95% CI -0.1% to 1. 5%) at 30 days, 3.0% (95% CI 0.8% to 5.2%) v 2.8% (95% CI 1.2% to 4. 4%) at six months, and 7.0% (95% CI 3.7% to 10.3%) v 5.7% (95% CI 3. 5% to 7.9%) at 24 months. Kaplan-Meier survival analysis showed no difference in mean event-free survival at 30 days, six months, and 24 months of follow up. CONCLUSIONS: Using a rule-out myocardial infarction protocol with a rapid and sensitive CK-MB(mass) assay and serial sampling, the length of stay of patients with chest pain in the cardiac emergency room can be reduced without compromising safety.  (+info)

Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma. (4/344)

OBJECTIVE: To examine whether successful coronary reperfusion after thrombolytic treatment in patients with confirmed acute myocardial infarction can be diagnosed from the plasma marker fatty acid binding protein (FABP), for either acute clinical decision making or retrospective purposes. DESIGN: Retrospective substudy of the GUSTO trial. SETTING: 10 hospitals in four European countries. PATIENTS: 115 patients were treated with thrombolytic agents within six hours after the onset of acute myocardial infarction. Patency of the infarct related artery was determined by angiography within 120 minutes of the start of thrombolysis. MAIN OUTCOME MEASURES: First hour rate of increase in plasma FABP concentration after thrombolytic treatment, compared with increase in plasma myoglobin concentration and creatine kinase isoenzyme MB (CK-MB) activity. Infarct size was estimated from the cumulative release of the enzyme alpha hydroxybutyrate dehydrogenase in plasma during 72 hours, or from the sum of ST segment elevations on admission. Logistic regression analyses were performed to construct predictive models for patency. RESULTS: Complete reperfusion (TIMI 3) occurred in 50 patients, partial reperfusion (TIMI 2) in 36, and no reperfusion (TIMI 0+1) in 29. Receiver operating characteristic (ROC) curve analyses showed that the best performance of FABP was obtained when TIMI scores 2 and 3 were grouped and compared with TIMI score 0+1. The performance of FABP as a reperfusion marker was improved by combining it with alpha hydroxybutyrate dehydrogenase infarct size, but not with an early surrogate of infarct size (ST segment elevation on admission). In combination with infarct size FABP performed as well as myoglobin (areas under the ROC curve 0.868 and 0.857, respectively) and better than CK-MB (area = 0.796). At optimum cut off levels, positive predictive values were 97% for FABP, 95% for myoglobin, and 89% for CK-MB (without infarct size, 87%, 88%, and 87%, respectively), and negative predictive values were 55%, 52%, and 50%, respectively (without infarct size, 44%, 42%, and 34%). CONCLUSIONS: FABP and myoglobin perform equally well as reperfusion markers, and successful reperfusion can be assessed, with positive predictive values of 87% and 88%, or even 97% and 95% when infarct size is also taken into account. However, identification of non-reperfused patients remains a problem, as negative predictive values will generally remain below 70%.  (+info)

Detection of minor myocardial injury after successful percutaneous transluminal coronary angioplasty with or without stenting. (5/344)

Cardiac troponins are sensitive and specific markers for the detection of minor myocardial injury. However, they have been rarely used to monitor myocardial injury after coronary stenting. The purpose of the study was to measure cardiac troponin I (cTnI) and cardiac troponin T (cTnT) levels after apparently successful percutaneous transluminal coronary angioplasty (PTCA) with or without coronary stenting and to compare their results with serum creatine kinase (CK) and its isoform, creatine kinase-MB (CKMB). CTnI and cTnT levels were compared with those of CK or CKMB in 50 consecutive patients with stable angina undergoing visually successful PTCA with stenting (n = 35) or without stenting (n = 15). Cardiac TnI, cTnT, CK and CKMB levels were measured before and 6, 24, and 48 hours after the procedures was performed. None of the patients had abnormal cTnI or cTnT levels, CK activity, or CKMB levels before the procedures. Moreover, no patient showed electrocardiographic evidence of myocardial infarction. 13 patients (26%) had abnormal peak values of one or more markers at 24 hours after coronary intervention. Troponin I was elevated in 10/35 patients after coronary stenting (29%) and in 2/15 patients after PTCA (13%) (P = 0.327). Troponin T was elevated in 6 patients (17%) and CKMB activity was elevated in 3 patients (9%) of the coronary stenting group. CTnI was more significant than CKMB (P = 0.023) in detecting minor myocardial injury. When compared with cTnI and CKMB, cTnT did not reach significance (P = 0.129 and 0.489, respectively). 5 out of the 13 patients with abnormal markers (38%) developed side branch occlusion after stenting. In conclusion, cTnI was a very sensitive marker in detecting minor myocardial injury after coronary angioplasty with or without stenting. The frequency of increased serum levels of cardiac troponins was higher in patients undergoing stent implantation than in those treated with angioplasty alone but did not reach significance. Side branch occlusion may have accounted for some, but not all, periprocedural minor myocardial injury in the stent group.  (+info)

Effects of implantable cardioverter defibrillator implantation and shock application on biochemical markers of myocardial damage. (6/344)

BACKGROUND: Implantable cardioverter defibrillator (ICD) implantation is a common approach in patients at high risk of sudden cardiac death. To check for normal function, it is necessary to test the ICD. For this purpose, repetitive induction and termination of ventricular fibrillation by direct current shocks is required. This may lead to minor myocardial damage. Cardiac troponin T (cTnT) and I (cTnI) are specific markers for the detection of myocardial injury. Because these proteins usually are undetectable in healthy individuals, they are excellent markers for detecting minimal myocardial damage. The objective of this study was to evaluate the effect of defibrillation of induced ventricular fibrillation on markers of myocardial damage. METHODS: This study included 14 patients who underwent ICD implantation and intraoperative testing. We measured cTnT, cTnI, creatine kinase MB (CK-MB) mass, CK activity, and myoglobin before and at definite times after intraoperative shock application. RESULTS: Depending on the effectiveness of shocks and the energy applied, the cardiac-specific markers cTnT and cTnI, as well as CK-MB mass, showed a significant increase compared with the baseline value before testing and peaked for the most part 4 h after shock application. In contrast, the increases in CK activity and myoglobin were predominantly detectable in patients who received additional external shocks. CONCLUSIONS: ICD implantation and testing leads to a short release of cardiac markers into the circulation. This release seems to be of cytoplasmic origin and depends on the number and effectiveness of the shocks applied.  (+info)

Production of recombinant human creatine kinase (r-hCK) isozymes by tandem repeat expression of M and B genes and characterization of r-hCK-MB. (7/344)

BACKGROUND: Serum creatine kinase-MB isoenzyme (CK-MB) is widely used as a marker of myocardial injury. We prepared recombinant human CK (r-hCK) MB isoenzyme and examined its potential for use as a control material for assay of CK-MB in serum. METHODS: cDNAs encoding CK-M and CK-B subunits were inserted into the same plasmid vector, followed by transformation of Escherichia coli. The resulting three types of CK isoenzymes were purified by conventional chromatography. RESULTS: The ratio of MB to MM to BB was 50:40:10 on the basis of CK activity. Highly purified CK-MB with a specific activity of 533 U/mg was produced in a yield of 5.7 mg/g of packed cells. Purified r-hCK-MB had the isoelectric point (pI 5.3) and molecular size (46 kDa for the subunit) of native CK-MB. Its immunoreactivity in an ELISA using antibody against native heart enzyme was similar to that of cardiac CK-MB. The r-hCK-MB retained >90% activity for at least 4 months at 11 degrees C in a delipidated serum matrix in a liquid form at a concentration of 118 U/L. CONCLUSIONS: r-hCK-MB shows key properties of the native cardiac isoenzyme and may be useful as a control and calibrator for serum assays of CK-MB.  (+info)

Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes. (8/344)

OBJECTIVES: We sought to determine the incidence of and risk factors for thrombotic events early after discontinuing antithrombin therapy in patients with acute coronary syndromes. BACKGROUND: Discontinuation of treatment with heparin and other thrombin inhibitors in patients with unstable coronary syndromes has related to clinical and biochemical evidence of early reactivation of thrombosis. METHODS: We studied 8,943 of the 12,142 patients with acute coronary syndromes enrolled in the Global Use of Strategies To Open occluded arteries in acute coronary syndromes trial of hirudin versus heparin. We excluded patients who received no study drug, lacked timing data, died or had myocardial (re)infarction [(re)MI] during study-drug infusion, or began heparin treatment within 2 h after treatment with the study drug was stopped. We assessed the incidence and timing of (re)MI by type and timing of antithrombin treatment. RESULTS: In all, 215 patients (2.4%) suffered (re)MI, 49 within 12 h of antithrombin therapy discontinuation and 166 between hour 12 and hospital discharge. The duration of infusion did not differ between the hirudin and heparin groups. The rate of early re(MI) after drug therapy discontinuation was significantly higher in patients given heparin versus hirudin (0.8% vs. 0.3%, p = 0.002). Patients with (re)MI had higher mortality at 30 days (23.6% vs. 2.4%, p = 0.001) and 1 year (35.2% vs. 6.7%, p = 0.001) compared with patients without (re)MI. CONCLUSIONS: The incidence of (re)MI was clustered within 12 h of heparin therapy discontinuation, with the greatest risk within 4 h. There was no evidence of early reactivation of thrombotic events after hirudin. Patients who had (re)infarction had worse outcomes. Better understanding of the mechanism and possible prevention of recurrent thrombosis is needed.  (+info)

*Hyperthyroidism

In hyperthyroidism CK-MB (Creatine kinase) is usually elevated. In overt primary hyperthyroidism, TSH levels are low and T4 and ... This form of hyperthyroidism usually corrects itself within weeks or months without the need for treatment. A struma ovarii is ... Anti-thyroid drugs for cats are available in both pill form and in a topical gel, that is applied using a finger cot to the ... Surgery (thyroidectomy to remove the whole thyroid or a part of it) is not extensively used because most common forms of ...

*Outline of cardiology

Creatine kinase - When skeletal muscle injury is absent, CK-MB is fairly specific to myocardium injury. Troponin - The troponin ... It is a form of PCI and generally what is implied when referring to "PCI." Atherectomy - Enlarging the lumen of an artery by ... Dressler syndrome - A form of pericarditis that develops 2-3 weeks after myocardial infarction and is accompanied by fever, ... Stable angina results if the angina resolves with rest or nitroglycerin, but can progress to unstable angina which is a form of ...

*Anorexia nervosa

Creatine Kinase Test (CK-Test): measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), ... The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which not all of the diagnostic criteria for AN are met, is ... Stargrove MB, Treasure J, McKee DL (2008). Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic ... Walder A, Baumann P (2008). "Increased creatinine kinase and rhabdomyolysis in anorexia nervosa". The International Journal of ...

*Heart

Testing for the MB form of creatine kinase provides information about the heart's blood supply, but is used less frequently ... Two endocardial tubes form here that fuse to form a primitive heart tube known as the tubular heart. Between the third and ... In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary ... These nerves form a network of nerves that lies over the heart called the cardiac plexus. The vagus nerve is a long, wandering ...

*Creatine kinase

... there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter ... Skeletal muscle expresses CK-MM (98%) and low levels of CK-MB (1%). The myocardium (heart muscle), in contrast, expresses CK-MM ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ...

*Hyperthyroidism

Surgery (thyroidectomy to remove the whole thyroid or a part of it) is not extensively used because most common forms of ... This form of hyperthyroidism usually corrects itself within weeks or months without the need for treatment. ... A struma ovarii is a rare form of monodermal teratoma that contains mostly thyroid tissue, which leads to hyperthyroidism. ... Thyrotoxicosis can also occur after taking too much thyroid hormone in the form of supplements, such as levothyroxine (a ...

*CKM (gene)

"The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase". J. Biol. Chem. 282 ... "Cardiac involvement of major thalassemia and evaluation of total serum creatine kinase and creatine kinase-mB isoenzyme and ... Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene. In the figure to the ... Creatine Kinase, MM Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKM genome location and ...

*CKB (gene)

Creatine Kinase, BB Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKB genome location and ... In heart, a heterodimer (CK-MB) shahil consisting of one CK-B brain-type CK subunit and one CK-M muscle-type CK subunit is ... Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein ... Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly ...

*Phosphocreatine

... is catalyzed by several creatine kinases. The presence of creatine kinase (CK-MB, MB for muscle/brain) in blood plasma is ... A 70kg adult male has around 120g of creatine in them, with 40% being the non phosphorylated form, and 60% as creatine ... A methyl group is added to GAA from the amino acid methionine by the enzyme GAMT, forming non-phosphorylated creatine. This is ... Once inside the cells it is transformed into phosphocreatine by the enzyme complex creatine kinase, which makes it able to ...

*CKMT2

Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively ... Klein SC, Haas RC, Perryman MB, et al. (1991). "Regulatory element analysis and structural characterization of the human ... Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene. Mitochondrial creatine kinase ( ... Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. ...

*Cardiac marker

September 1997). "Assessment of coronary reperfusion after thrombolysis with a model combining myoglobin, creatine kinase-MB, ... AAK31795) is the soluble form of uPAR. uPAR is a membrane bound receptor for uPA, otherwise known as urokinase. suPAR results ...

*CKMT1B

Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ... Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. ... Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine ...

*C3orf62

... elevated serum creatine kinase levels, and white matter involvement". Wiley Online Library. American Journal of Medical ... Transcription of C3orf62 produces 5 alternatively spliced variants and 1 unspliced form. Of the four splice variants, two of ... "A 3.1 Mb Microdeletion of 3p21.31 Associated with Cortical Blindness, Cleft Lip, CNS Abnormalities, and Developmental Delay". ... No ortholog sequences of C3orf62 were found for the following life forms: Bacteria, archaea, protist, plant, fungus, trichoplax ...

*Ion chromatography

Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column chromatography". ... This competition led to fast growth of new forms and the fast evolution of IC.[11] A challenge that needs to be overcome in the ... Studies about CK-MB found in heart attack victims have expanded since this study and application of ion chromatography. ... A buffered aqueous solution known as the mobile phase carries the sample from the loop onto a column that contains some form of ...

*Myocardial infarction

Commonly used blood tests include troponin and less often creatine kinase MB. Treatment of an MI is time critical. Aspirin is ... A collagen scar forms in their place. When an artery is blocked, cells lack oxygen, needed to produce ATP in mitochondria. ATP ... Other tests, such as CK-MB or myoglobin, are discouraged. CK-MB is not as specific as troponins for acute myocardial injury, ... A cholesterol core forms as foam cells die. In response to growth factors secreted by macrophages, smooth muscle and other ...

*Ion chromatography

ISBN 0-444-88232-4. Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column ... Studies about CK-MB found in heart attack victims have expanded since this study and application of ion chromatography. Since ... This competition led to fast growth of new forms and the fast evolution of IC. A challenge that needs to be overcome in the ... Firstly, CK- MM was eluted, then CK-MB, followed by CK-BB. Therefore, the isoenzymes found in each sample could be used to ...

*List of MeSH codes (D08)

... creatine kinase, bb form MeSH D08.811.913.696.640.150.625 --- creatine kinase, mb form MeSH D08.811.913.696.640.150.750 --- ... creatine kinase, mitochondrial form MeSH D08.811.913.696.640.150.875 --- creatine kinase, mm form MeSH D08.811.913.696.645 --- ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ...

*Chest pain

Liver enzymes Creatine kinase (and CK-MB fraction in many hospitals) D-dimer (when suspicion for pulmonary embolism is present ... another benign and harmless form of a sharp, localised chest pain often mistaken for heart disease Breast conditions Herpes ...

*Liver function tests

"Cardiac troponin T and I and creatine kinase-MB as markers of myocardial injury and predictors of outcome following ... albumin-binding unconjugated bilirubin into a form that is more hydrophilic and able to be secreted in urine, sparing the ... although troponin and creatine kinase tests are more preferred. Reference ranges for blood tests Elevated transaminases Liver ...

*Chest pain

Creatine kinase (and CK-MB fraction in many hospitals). *D-dimer (when suspicion for pulmonary embolism is present but low) ... Precordial catch syndrome - another benign and harmless form of a sharp, localized chest pain often mistaken for heart disease ...

*Neosaxitoxin

Cheng HS, Chua SO, Hung JS, Yip KK (April 1991). "Creatine kinase MB elevation in paralytic shellfish poisoning" (PDF). Chest. ... Nav channels form the basis for electrical excitability in animals. Nav channels evolved from Ca2+ channels and were present in ... other forms of aquatic animal life other than birds or mammals, and all mollusks; and incorporate the use of "ppm" as another ... which can form extensive blooms around the world. Under special conditions, during harmful algal blooms (HAB) or red tide, all ...

*SLC25A5

Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M (Dec 2001). "Mitochondrial creatine kinase and mitochondrial outer ... This gene consists of 4 exons, while its encoded protein forms a homodimer embedded in the inner mitochondrial membrane. The ... Dehouck MB, Devriendt K, Fryns JP, Marynen P, Goldstein A, Froyen G (Oct 2013). "The mitochondrial solute carrier SLC25A5 at ... In later stages of apoptosis the entire cell becomes fragmented, forming a number of plasma membrane-bounded apoptotic bodies ...

*P110α

"The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes & Development ... Chr 3: 179.15 - 179.24 Mb. Chr 3: 32.4 - 32.47 Mb. PubMed search. [3]. [4]. ... 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". ... 1-phosphatidylinositol-3-kinase activity. • phosphatidylinositol-4,5-bisphosphate 3-kinase activity. • kinase activity. • ...

*Barotrauma

Creatine kinase (CPK) level: Increases in CPK levels indicate tissue damage associated with decompression sickness. ... 90 This form of barotrauma is avoidable by controlled descent rate, which is standard practice for commercial divers, who will ... 30 to 50 mb). As an indicator of transalveolar pressure, which predicts alveolar distention, plateau pressure or peak airway ...

*Citrate synthase

This forms a tetrahedral intermediate and results in the ejection of −SCoA as the carbonyl reforms. The −SCoA is protonated to ... Adenylate kinase. *Creatine kinase. Inner membrane. oxidative phosphorylation. *Coenzyme Q - cytochrome c reductase ... Chr 12: 56.27 - 56.3 Mb. Chr 10: 128.34 - 128.36 Mb. PubMed search. [3]. [4]. ... Only when this citroyl-CoA has formed will another conformational change cause thioester hydrolysis and release coenzyme A. ...
Percutaneous coronary intervention (PCI) may be complicated by post-procedural myocardial injury/infarction as manifested by elevated cardiac biomarkers such as creatine kinase-myocardial band or troponin T. The occurrence of post-procedural myocardial injury/infarction has been shown to be associated with worse short- and long-term clinical outcome (1,2), and even mild elevation of cardiac troponin after PCI has been related to a worse prognosis (3). Intravascular ultrasonography (IVUS) has shown that post-procedural myocardial injury/infarction is caused by lesions with ruptured plaques and/or those with a greater plaque burden (4). Virtual histology IVUS also has shown that post-PCI cardiac troponin (cTnT) elevation occurs in lesions with a large necrotic core area and positive remodeling (PR) of the vessel (5).. Multidetector computed tomography (MDCT) is a promising technique for noninvasive coronary angiography. With the development of MDCT, it is possible not only to detect coronary ...
Over the past several decades, we have made substantial progress in the early diagnosis and management of acute myocardial infarction (AMI). Throughout most of our careers, the diagnosis of AMI required that at least 2 of 3 criteria were met: prolonged ischemic symptoms, diagnostic electrocardiographic (ECG) changes, and elevation of total creatine kinase (CK) with creatine kinase-myocardial band (CK-MB) exceeding 3 times the upper limit of normal. Over the past several decades, these diagnostic criteria were repeatedly validated with evidence showing that the level of CK-MB was highly predictive of infarct size, development of heart failure, as well as short- and long-term mortality. Given these findings, why have many hospitals abandoned measurement of CK-MB in favor of troponin?. Unfortunately CK is present in other tissues, such as skeletal muscle or brain; thus the clinician used the % MB index and the typical rise and fall to determine the clinical significance of any CK elevation. It was ...
Results:. Of 69 patients with myocardial infarction, only 39% had diagnostic electrocardiographic ST-segment elevation. ST-segment elevation had a specificity of 99% and a positive predictive value of 93%. A relative lymphocytopenia (lymphocyte decrease ,20.3%) or elevated rapid creatine kinase-MB level (,4.7 ng/mL) was more sensitive than ST-segment elevation (sensitivities of 58% and 56%, respectively) but less specific (specificities of 91% and 93%, respectively). The presence of both a relative lymphocytopenia and an elevated rapid creatine kinase-MB level had a sensitivity of 44%, a specificity of 99.7%, and a positive predictive value of 97% (95% CI, 80% to 99%). Both a relative lymphocytopenia and an elevated rapid creatine kinase-MB level were independent (P , 0.001) predictors of infarction in patients without ST-segment elevation. If myocardial infarction was suspected by the presence of both abnormal markers or ST-segment elevation, the sensitivity for early diagnosis increased from ...
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We offer innovative solutions for assay development and research applications by providing immunological reagents for IVD industry and research groups.
The definition of myocardial infarction (MI) continues to evolve as refined ECG criteria, more advanced imaging, and more sensitive and specific biomarkers are developed. The acceptance globally of a clinically practical standard definition for everyday practice would allow for better comparisons across clinical experiences and further facilitate research in this critical area. Because of the evolution of better diagnostic tools and more information about the value and limitations of previous definitions, there was a need to update the Universal Definition of MI published in 20071 and this has recently been accomplished.2 Great efforts were made by the taskforce that developed these guidelines to establish clinical criteria which correspond to the contemporary management of patients suspected of having MI. Therefore, a combination of clinical symptoms, cardiac biomarkers, and ECG changes indicative of myocardial ischaemia are central to the 2012 Third Universal Definition of MI. It stresses the ...
A 69-year-old man presented with 2 weeks of exertional chest pressure typical of angina pectoris. An exercise stress test reproduced his symptoms and caused 1.5 mm of ST depression. Because a relative had a fatal event associated with invasive coronary angiography, he wished to have only noninvasive testing. Coronary computed tomographic (CT) angiography using 16-slice technology (Siemens Sensation 16) demonstrated a severe proximal left anterior descending artery lesion (Figure 1). A ruptured plaque was found with 14 Hounsfield units (HU) in one region and 60 HU in the remainder of this atheroma (Figure 2). The patient subsequently agreed to coronary angiography (Figure 3) and a stent was placed. This was complicated by transient slow flow and creatine kinase-MB elevation (110 IU). CT imaging demonstrating low HU suggests either thrombus or a lipid-laden lesion consistent with a ruptured vulnerable plaque. Its association with ruptured plaque thus identified the left anterior descending artery ...
MSF launched a program targeted at treating cardiac emergencies in Grozny, Chechnya, in late 2010. Within just a few months, the program treated nearly 700 patients.
Learn EMT - Cardiac Emergencies facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
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The Global Cardiac Biomarkers Testing Market size is expected to reach $16.2 billion by 2025, rising at a market growth of 11.4% CAGR during the forecast p
The Task Force for the Universal Definition of Myocardial Infarction recently published updated guidelines for the clinical and research diagnosis of myocardial infarction under a variety of circumstances and in a variety of categories. A type 1 myoc
We believe that one of the drivers of the obesity epidemic is ready access to energy dense, hyperpalatable foods, says an expert. Having a standard, universal definition is therefore key.
In the event of a cardiac emergency, it is needless to say that time means muscle. Rest assured that at the Emergency Department of NICVD, time is of vital importance to our physicians and medical staff.. Patients rushed in with cardiac emergencies manifested by chest pains, shortness of breath, palpitations and other symptoms are provided rapid appropriate treatment by our trained physicians, cardiologists, skilled nurses and nurse aid.. The emergency department at NICVD is accessible 24 hours, 7 days a week and consists of separate areas for males and females. Coordinating with local ambulance services in the city of Karachi, we receive and tend to an average of 600 - 1000 patients per day.. ...
Background: Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels.. Materials and Methods: We studied 118 consecutive patients presenting within 3 h of the onset of an acute neurological deficit [84 brain infarctions (BI), 18 brain hemorrhages (ICH) and 16 transient ischemic attacks lasting less than 1 h or epileptic seizures]. Serum samples were obtained for all patients at initial presentation and repeated only in patients with stroke at 6, 12 and 24 h. IMA was measured by the albumin-cobalt-binding test (Ischemia Technologies, Denver, Colo., USA). Results: The initial median IMA (bootstrap 95% confidence interval, CI) was 83 U/ml (79-86) and 86 U/ml (75-90) in patients with BI and ICH, respectively (p = 0.76), and was 73 U/ml (58-79) in others (p = 0.003 compared with BI, and p = 0.017 with ICH). Baseline IMA ...
Is there a relation between myocardial salvage and the release patterns of myoglobin and creatine kinase-MB in acute myocardial infarction submitted to thrombolysic ...
The global Cardiac Biomarkers market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022
AccessGUDID - CK-MB CONTROL (05055273201413)- The device is intended for use in the quality control of CK-MB assays on clinical chemistry systems.
(EMAILWIRE.COM, January 12, 2018 ) Asia Pacific Cardiac Marker Testing Market Size is expected to grow at 11.7% CAGR from 2016 to 2021 and it is projected that the Asia-Pacific market was valued at USD 0.37 billion in 2016 and is anticipated to reach USD 0.64 billion by 2021. Cardiac Bio-Marker...
Background The development of sensitive myocardial-specific cardiac biomarkers allows for detection of very small amounts of myocardial injury or necrosis. Myocardial injury (MI) as a prelude of the...
A CK-MB blood test can help differentiate heart damage from other muscle injuries. Take care of your heart and order affordable lab testing from Request A Test. We work with 1000s of labs nationwide.
Leading a healthy lifestyle remains top of mind for consumers globally, and Canadians are no exception. And while there is no universal definition for what "healthy" means, most people focus on products and services that deliver the best for their families, and thats a key driver of shopping ...
The definition of myocardial infarction (MI) continues to evolve as refined ECG criteria, more advanced imaging, and more sensitive and specific biomarkers are developed. The acceptance globally of a clinically practical standard definition for everyday practice would allow for better comparisons across clinical experiences and further facilitate research in this critical area. Because of the evolution of better diagnostic tools and more information about the value and limitations of previous definitions, there was a need to update the Universal Definition of MI published in 20071 and this has recently been accomplished.2 Great efforts were made by the taskforce that developed these guidelines to establish clinical criteria which correspond to the contemporary management of patients suspected of having MI. Therefore, a combination of clinical symptoms, cardiac biomarkers, and ECG changes indicative of myocardial ischaemia are central to the 2012 Third Universal Definition of MI. It stresses the ...
United States Creatine Kinase-MB (CK-MB) Market Report 2016 is a market research report available at US $3800 for a Single User PDF License from RnR Market Research Reports Library.
Creatine Kinase MB小鼠单克隆抗体[CK1](ab404)可与人样本反应并经ELISA, RIA实验严格验证,被2篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Following acute myocardial infarction, CK-MB activity increases significantly and this elevation is highly specific for the laboratory diagnosis of myocardial infarction. Although total CK activity usually increases following myocardial infarction, in some patients only the CK-MB activity increases, while the total CK remains in the normal range. In this procedure CK activity is measured in the presence of an antibody to CK-M monomer. This antibody completely inhibits the activity of CK-MM and half of the activity of CK-MB, while not affecting the B subunit activity of CK-MB and CK-BB. Due to negligible concentrations of CK-BB in the circulation, the remaining activity, multiplied by a factor of 2, represents the activity of the CK-MB isoenzyme ...
Criteria for abnormality: Hemoglobin greater than or equal to(,=)130*lower limit of normal(LLN); less than or equal to(,=)170*upper limit of normal(ULN), hematocrit ,=0.39*LLN;,=0.51*ULN, red blood cell ,=4.5*LLN;,=5.9*ULN, platelet,=150*LLN;,= 450*ULN, white blood cells ,=4*LLN;,=11*ULN; lymphocytes,=0.09;,=0.44, neutrophils=,0.16*LLN;,=0.7*ULN, eosinophils,=0.04*ULN, basophils,=0.02*ULN, monocytes,0.08*ULN; bilirubin ,=5.1*LLN;,=22.2*ULN, aspartate aminotransferase ,=13*LLN;,=36*ULN, alanine aminotransferase,=11*LLN;,=54*ULN, alkaline phosphatase,=31*LLN ;,=104 *ULN, total protein,=60*LLN; ,=76*ULN, albumin=,35*LLN;,=50*ULN, glucose,=3.77 ;,=6.05;blood urea nitrogen,=1.785*LLN;,=7.5*ULN, creatinine,=70.7*LLN;,=114.9*ULN, creatinine kinase,=30*LLN ;,=280*ULN, lactate dehydrogenase,=85*LLN;,=180*ULN, sodium,=137*LLN ;,=144*ULN, potassium ,=3.5*LLN;,=5*ULN, chloride,=102*LLN;,=111*ULN, calcium,=2.22*LLN ;,=2.57*ULN, phosphorus=,0.81 ;,=1.45); nitrogen cholesterol,=1.78*LLN ;,=7.49*ULN ...
The report demonstrates a far reaching blueprint of the whole headway heading of the market over the navigation of the figure time traverse. Unmistakable zones have been considered to give the perusers a broad perspective of the whole market condition. The commanding scene in thought with the principal affiliations and the affiliations working in the market has been incorporated and examined upon minutely. Unmistakable locales have in addition been cleared up where the market is working feasibly and the areas where the players may discover lucrative open passages later on have in like way been said in the report.. Cardiac biomarkers are the substances used to identify the hazard stratification of a patient with chest torment or suspected intense coronary disorder (ACS). These biomarkers are discharged in blood when the heart is harmed or pushed. The tests that are done by acquainting the cardiac biomarkers with the circulation system help in deciding the dangers of related heart conditions, for ...
We are classically taught to activate the cath lab for patients with STEMI or new LBBB. Given the unreliability/lack of specificity of new LBBB for diagnosis of myocardial infarction, it has been removed as a hard criteria for cath lab activation in the latest iteration (2013) of AHA/ACCF guidelines (Ref 4). The current Universal Definition of acute Myocardial infarction is: "new ST elevation at the J point in at least 2 contiguous leads of 2 mm (0.2 mV) in men or 1.5 mm (0.15 mV) in women in leads V2-V3 and/or of 1 mm (0.1mV) in other contiguous chest leads or the limb leads." According to the AHA, "New or presumably new LBBB has been considered a STEMI equivalent. Most cases of LBBB at time of presentation, however, are "not known to be old" because of prior electrocardiogram (ECG) is not available for comparison. New or presumably new LBBB at presentation occurs infrequently, may interfere with ST-elevation analysis, and should not be considered diagnostic of acute myocardial infarction (MI) ...
Inclusion: Cohort of Medicare beneficiaries ≥ 65 years of age admitted to hospital from Feb. 1, 1994 to July 30, 1995 with documented LVEF , 40% (measured by echocardiography, radionuclide scintigraphy, angiography) following confirmed acute MI. Acute MI was diagnosed as a creatine kinase-MB , 5% or a 2-fold elevated LDH-2 or the patient met 2 of the 3 following criteria: chest pain, creatine kinase level at least 2-fold greater than normal, or evidence of acute MI confirmed by electrocardiography ...
by Maureen McMichael, Ryan Fries May 2016 Life-Threatening Cardiac Emergencies for the Small Animal Practitioner offers a quick reference to recognizing …. Read More » ...
(KudoZ) English to Georgian translation of Myocardial necrosis biomarkers sample: მიოკარდიუმის ნეკროზის ბიომარკერების ნიმუში [Name of a Course - Medical (general) (Medical)].
Informaţii generale CK-MB este fracţiunea miocardică a creatinkinazei asociată cu infarctul miocardic. Este utilă pentru a estima mărimea zonei de necroză1. Recomandări pentru determinarea CK-MB Pentru stabilirea valorilor bazale ale enzimei este necesară recoltarea probei pacientului la debutul bolii, după care se va
34)高度低左心機能・重症多枝病変に対し有茎三本動脈グラフトによるoff-pump CABG(OPCAB)を施行した一治験例 (2003 ...
Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis? Abdurrahman Sahin,1 Semra Turkoglu,2 Nurettin Tunc,1 Deccane Duzenci,3 Ozgen Arslan Solmaz,4 Ibrahim Halil Bahcecioglu,1 Mehmet Yalniz1 1Medicine Faculty, Department of Gastroenterology, Firat University, Elazig, Turkey; 2Department of Nutrition and Dietetics, Health Sciences Faculty, Firat University, Elazig, Turkey; 3Department of Internal Medicine, Elazig Education and Training Hospital, Elazig, Turkey; 4Department of Pathology, Elazig Education and Training Hospital, Elazig, Turkey Purpose: Oxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP.Patients and methods: A
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Cardiac markers are biomarkers measured to evaluate heart function. They are often discussed in the context of myocardial infarction, but other conditions can lead to an elevation in cardiac marker level. Most of the early markers identified were enzymes, and as a result, the term "cardiac enzymes" is sometimes used. However, not all of the markers currently used are enzymes. For example, in formal usage, troponin would not be listed as a cardiac enzyme. Measuring cardiac biomarkers can be a step toward making a diagnosis for a condition. Whereas cardiac imaging often confirms a diagnosis, simpler and less expensive cardiac biomarker measurements can advise a physician whether more complicated or invasive procedures are warranted. In many cases medical societies advise doctors to make biomarker measurements an initial testing strategy especially for patients at low risk of cardiac death. Many acute cardiac marker IVD products are targeted at nontraditional markets, e.g., the hospital ER instead ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Looking for online definition of cardiac enzymes in the Medical Dictionary? cardiac enzymes explanation free. What is cardiac enzymes? Meaning of cardiac enzymes medical term. What does cardiac enzymes mean?
BULGULAR: Yirmi dokuz (%67.4) hastaya hafif AP tan s konarken, 14 (%32.6) hasta orta iddetli veya iddetli hastal k formuna sahipti ve iddetli AP olarak s n fland r ld . Hasta gruplar aras nda MA d zeylerinde anlaml bir fark yoktu (p=0.737). skemi modifiye alb min d zeyleri ile amilaz d zeyleri (p=0.470), Ranson skoru (p=0.664) ve hastal k iddeti (p=0.741) aras nda korelasyon saptanmad ...
San Francisco, Sept. 05, 2016-- The cardiac biomarkers market is expected to reach USD13.3 billion by 2024, according to a new report by Grand View Research, Inc. The cardiac biomarkers market is anticipated to witness a lucrative growth during the forecast period from 2016 to 2024. Analysis of global market trends focuses on the increasing demand for cardiac...
CK is a dimeric enzyme. There are two common gene products, one coding for the subunit (so named because of its predominance in muscle) and the other for the B subunit (so named because of its predominance in brain tissue). The three common forms of active CK include two homodimers and one heterodimer. The first homodimer (CK-1) consists of two B subunits and is referred to as CKBB. The other has two M subunits and is referred to as CKMM (CK-3). The heterodimer has one of each subunit and is referred to as CKMB (CK-2)2. The specificity of CKMB for cardiac tissue is what has made it such a powerful diagnostic tool for the diagnosis of acute myocardial infarction (AMI). There is a third gene product which results in the mitochondrial form of CK.. Along with CKMB, significant levels of CKMM activity are found in cardiac muscle and therefore a large increase in total CK was once used as a tool in the diagnosis of AMI3. Once the CK isoenzymes were elucidated and isoenzyme tests became available, CKMB ...
In this retrospective study, 1-cm-thick transverse sections of the ventricles were cut from the base to the apex in the necropsy hearts of 27 patients aged 47 to 86 years (mean 66, median 69; 19 men). Total and necrotic areas were measured using a computer-linked image analysis system. The weights of the necrotic areas were also calculated ...
global cardiac biomarkers market covers segments, by type (myocardial muscle creatine kinase (CK-MB), troponins (T, I), myoglobin, brain natriuretic peptide (BNPs) or NT-proBNP), location of testing (point of care testing, laboratory testing), applications (myocardial infarction), trends, CAGR, forecast up to 2025
Abnormalities were determined from laboratory measurements analyzed at the central or local laboratory. Division of AIDS Table (DAIDS) for Grading Severity of Adult and Pediatric AEs version (v) Dec 2004. Upper limit of normal (ULN): lower limit of normal (LLN), alanine transaminase (ALT); aspartate aminotransferase (AST); alkaline phosphatase (ALP). ALT Grade (Gr) 1: 1.25 to 2.5*ULN; Gr 2: 2.6 to 5.0*ULN; Gr 3: 5.1 to 10.0*ULN; Gr 4: ,10.0*ULN. AST Gr 1: 1.25 to 2.5*ULN; Gr 2: 2.6 to 5.0*ULN; Gr 3: 5.1 to 10.0*ULN; Gr 4: ,10.0*ULN. Total bilirubin Gr 1: 1.25 to 1.5*ULN; Gr 2: 1.6 to 2.5*ULN; Gr 3: 2.6 to 5.0*ULN; Gr 4: ,5.0*ULN. ALP (U/L) Gr 1: 1.25 to 2.5*ULN, Gr 2: 2.6 to 5.0*ULN, Gr 3: 5.1 to 10.0*ULN, Gr 4: ,10.0*ULN. Albumin (low) Gr 1: 3 grams per deciliter (g/dL) to ,LLN ; Gr 2: 2.0-2.9 g/dL; Gr 3: , 2 g/dL. Gr 4: Not applicable. Baseline visit was within 50 days after the screening visit and was prior to start of study medication (Week 1 ...
This test measures the amount of the enzyme creatine kinase in your blood. A certain form of this enzyme can help find out whether youre having a heart attack.
The heart is an impressive organ that works tirelessly 24/7, all our lives. However, sometimes while performing this heavy duty, it faces certain difficulties. Cardiac emergencies such as cardiac arre...
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We are in the business of saving lives. Reflecting on our commitment to enable faster and better response to cardiac emergencies, the Heart&Stroke Resuscitation Summit showcased the latest in resuscitation science, practice and training. It was a unique opportunity to advance knowledge and life-saving skills while connecting with Canadian and international experts ...
Foreword of Origins of Life. In order to fully appreciate the complexity of life, one must first acknowledge the multiple definitions and applications of the word. Dr. Tom Davis, having a biological background, led a discussion that revealed the diverse connotations of the word "life," ultimately allowing us to interpret the different meanings and relate it to our being. The word "life" to one person could refer to the possibility of extraterrestrial life, while to another it could spark interest in life after death. As individuals, "life" could encompass numerous meanings, including synthetic life, the diversification of life, and its origin. Since the scope is so broad and can have multiple interpretations, there is the necessity for a universal definition to divide the broad range into general categories. There are two main definitions of life; life as a property and life as a category. Life as a property is specified as the unique or defining characteristics of living things. An example of ...
The latter definition of "machine gun" is of course highly misleading. "Machine gun" means a gun that shoots more than one round per trigger pull; thats the nearly universal definition. Semiautomatic guns arent machine guns.. Whats more, this definition labels as a machine gun the overwhelming majority of all semiautomatic guns, since even those semiautomatic guns that come with a smaller magazine can generally be used with a larger magazine -- the only "conversion" required is simply slapping in the bigger magazine. But in any event, regardless of what labels the D.C. law uses, it likely covers about half or more of the guns that are sold throughout the country, including most standard handguns (other than revolvers) and most semiautomatic rifles.. And this law imposes liability for manufacturing and distributing semiautomatic weapons even if the manufacturers and dealers are distributing the guns far outside D.C., in a jurisdiction where the guns are perfectly legal -- and semiautomatic ...
Cardiac enzymes are substances that are found in the tissues of the heart. Raised levels of the enzymes can help in the diagnosis of certain heart conditions such as heart attack.
Monthly program for assessing cardiac health including D-dimer, that are tested in clinical labs near patient/POC settings worldwide
Ischemia-modified albumin (IMA) is assumed “N-terminal modified” albumin which is generated immediately following myocardial ischemia. The diagnosis of IMA is based on reduced cobalt binding affinity to albumin which is attributed mainly to incapability of cobalt to bind at albumin’s modified N-terminus. Although the albumin cobalt binding test was accepted as a potentially powerful marker for discriminating acute coronary syndrome from nonischemic chest pain, its usefulness has been brought into question in recent years. Patients with acutely ischemic myocardium exhibit a rapid increase in serum levels of fatty acids (FAs). Almost all released FAs are strongly bound to albumin which create conformational changes in the protein with resultant reduced cobalt binding affinity. There is a clear metabolic and temporal relationship between IMA measured via albumin cobalt binding testing and serum levels of FAs. In line with what has been suggested recently in the literature, we conclude
The relationship between periprocedural myocardial infarction and subsequent target vessel revascularization following percutaneous coronary revascularization: insights from the EPIC trial. Evaluation of IIb/IIIa platelet receptor antagonist 7E3 in Preventing Ischemic Complications.
PIOMBO, Alfredo C et al. Clinical Significance of High Troponin T with Normal Creatine Kinase Levels on Ventricular Function in Acute Coronary SyndromesClinical Significance of High Troponin T with Normal Creatine Kinase Levels on Ventricular Function in Acute Coronary Syndromes Background. Rev. argent. cardiol. [online]. 2012, vol.80, n.2, pp. 145-150. ISSN 1850-3748.. The role of elevated troponins to predict changes on ventricular function in patients with high creatine kinase (CK) levels has been well established; yet, little is known about the clinical significance of high troponin levels with normal CK levels. Objectives To analyze the relation between Troponin T (TnT) levels and global and regional left ventricular function in patients with acute coronary syndromes (ACS) with normal CK and CK-MB levels. Material and Methods We included patients admitted to the coronary care unit due to ACS within 48 hours from symptoms onset with elevated TnT levels measured by quantitative determination ...
The results of the study by Stewart and colleagues confirm previous findings showing that successful coronary reperfusion leads to an accelerated increase in the levels of plasma markers of myocardial injury in patients treated with thrombolytic therapy for MI (1-3). Changes in the level of myoglobin have been found in almost all previous studies to be useful in detecting coronary reperfusion but may lack specificity because this marker is not cardiac-specific. Rapid increases in CKMB, MB isoforms, and troponin may offer enhanced specificity but may be less sensitive because early changes in levels of these compounds are less marked than those of myoglobin. Differences also exist in the performance of the available assays for these markers. This is important for development of clinical criteria for failure of reperfusion. Nonetheless, available data suggest that using ratios of 60- and 90-minute levels to the initial levels of some of these markers is reasonably accurate for assessing the ...
Twenty-seven papers, with discussions, from a program held by the American College of Cardiology at Ponte Vedra, Florida: physiology of sudden death and hemodynamics of cardiovascular collapse; diagnostic approaches; drug, bypass, and pacemaker therapy; prevention; and special topics including drowning, lightning stroke, and electric shock. Subject and author indexes. Will be of value mainly to those physicians with some competence in these areas who wish to sample other views. Not a coherent textbook. ...
The significance of elevated levels of the MB isomer of creatine kinase (CK-MB) when creatine kinase (CK) level is normal was studied in 400 patients with suspected acute myocardial infarction (AMI). In 350 patients both CK and CK-MB were elevated (group 1), in 21 only CK-MB was elevated (group 2), in 24 neither enzyme was elevated (group 3) and in 5 only CK was elevated (group 4). In 57% of patients in group 2 the CK level was doubled, with a characteristic enzyme curve, within the normal range, suggesting that an increase in CK had been missed because arbitrary definitions of normal were used. The median CK increase (60 IU/liter) in group 2 was greater than that in group 3 (23 IU/liter) (p | 0.001). Patients in group 1 with small AMIs had a relative increase in CK similar to that in group 2. However, patients in group 2 had a lower baseline CK level so that peak CK did not become abnormally high despite a 5-fold increase in some patients. In patients in group 1 with small AMIs, CK was elevated in
This paper describes very rare chemical poisoning and characteristics of patients with acute endosulfan mass poisoning in a rural area of Turkey and our experiences of these patients. We included 41 patients who were treated in our hospital with the diagnosis of endosulfan poisoning. After the first vital intervention they were examined in terms of age, sex, symptoms and physical examination findings, laboratory results, treatment and outcome. Forty-one patients were admitted to the emergency department (ED) after triage. Nineteen (46.3%) of the patients were female, 22 (53.7%) were male. The mean age was 279 +/- 16.0 years (1-67 years). The mean time to the ED was 4.1 +/- 0.9 h (3-6.5 h). The most common symptoms were anxiety (976%), nausea (56.1%) and vomiting (48.8%). Tests of the blood samples obtained at the ED revealed leucocytosis (11070.6 +/- 4302.5/mu l), increased blood glucose, LDH, CK and CK-MB levels. Toxicological analysis of blood and urine samples revealed endosulfan as the ...
MP Biomedicals has a wide range of Rapid test & Immuno assay test Kits to diagnose different Cardiac markers like, serum accute phase proteins (CRP proteins) and other Cardiac proteins. These diferent cardiac markers cover some enzymes to screen myocardial infraction.It also consists of some proteins, motor proteins helps to make cardiac muscle contraction and relaxation. Learn More ...
Heres a snippet from the December 2012 release of the new 2013 AHA STEMI Management Guidelines, which has a couple of subtle changes to the diagnostic ECG criteria for STEMI, which may come up in the exam. You can access the full guideline here:. "STEMI is a clinical syndrome defined by characteristic symptoms of myocardial ischemia in association with persistent electrocardiographic (ECG) ST elevation and subsequent release of biomarkers of myocardial necrosis. Diagnostic ST elevation in the absence of left ventricular (LV) hypertrophy or left bundle-branch block (LBBB) is defined by the European Society of Cardiology/ACCF/AHA/World Heart Federation Task Force for the Universal Definition of Myocardial Infarction as new ST elevation at the J point in at least 2 contiguous leads of ≥2 mm (0.2 mV) in men or ≥1.5 mm (0.15 mV) in women in leads V2-V3 and/or of ≥1 mm (0.1 mV) in other contiguous chest leads or the limb leads (7). The majority of patients will evolve ECG evidence of Q-wave ...
Heres a snippet from the December 2012 release of the new 2013 AHA STEMI Management Guidelines, which has a couple of subtle changes to the diagnostic ECG criteria for STEMI, which may come up in the exam. You can access the full guideline here:. "STEMI is a clinical syndrome defined by characteristic symptoms of myocardial ischemia in association with persistent electrocardiographic (ECG) ST elevation and subsequent release of biomarkers of myocardial necrosis. Diagnostic ST elevation in the absence of left ventricular (LV) hypertrophy or left bundle-branch block (LBBB) is defined by the European Society of Cardiology/ACCF/AHA/World Heart Federation Task Force for the Universal Definition of Myocardial Infarction as new ST elevation at the J point in at least 2 contiguous leads of ≥2 mm (0.2 mV) in men or ≥1.5 mm (0.15 mV) in women in leads V2-V3 and/or of ≥1 mm (0.1 mV) in other contiguous chest leads or the limb leads (7). The majority of patients will evolve ECG evidence of Q-wave ...
United States Cardiac Biomarkers Market Report 2016 is a market research report available at US $3800 for a Single User PDF License from RnR Market Research Reports Library.
This course will prepare you to recognize and care for breathing and cardiac emergencies involving adults and meets OSHA/workplace requirements
This course will prepare you to recognize and care for breathing and cardiac emergencies involving adults and meets OSHA/workplace requirements
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The detection of myoglobin (Myo), cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and b-type natriuretic peptide (BNP) plays a vital role in diagnosing cardiovascular diseases. Here we present single site-specific polyaniline (PANI) nanowire biosensors that can detect cardiac biomarkers such as Myo, cTnI, CK-MB, and BNP with ultra-high sensitivity and good specificity. Using single PANI nanowire-based biosensors integrated with microfluidic channels, very low concentrations of Myo (100 pg/mL), cTnI (250 fg/mL), CK-MB (150 fg/mL), and BNP (50 fg/mL) were detected. The single PANI nanowire-based biosensors displayed linear sensing profiles for concentrations ranging from hundreds (fg/mL) to tens (ng/mL). In addition, devices showed a fast (few minutes) response satisfying respective reference conditions for Myo, cTnI, CK-MB, and BNP diagnosis of heart failure and for determining the stage of the disease. This single PANI nanowire-based biosensor demonstrated superior biosensing reliability with the
The primary endpoint of death or MI at 30 days occurred in 15.2% of the pexelizumab group and 16.3% of the placebo group (relative risk reduction [RRR] 6.7%, p=0.201). Among the components of the composite, MI occurred in 12.6% of the pexelizumab group and 13.3% of the placebo group, (p=0.311) and death in 3.8% and 4.6%, respectively (RRR 17%, p=0.177). Results of the primary endpoint were similar in the different risk factor subgroups. Serious adverse events did not differ by treatment group (31.2% for pexelizumab and 32.5% for placebo). Sepsis occurred less often in the pexelizumab group (2.1% for 3.1%).. ...
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Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
[149 Pages Report] Cardiac Marker Testing Market report categories the Global market by Product (Instrument, Reagent), Method (ELISA, Chemiluminescence), Type (Troponin I & T, CK-MB, Myoglobin, BNP, hsCRP), Disease (Congestive Heart Failure, Myocardial Infarction), Testing (Lab, POC) & Geography
We painted the perfect picture for you in your cardiac emergencies lecture in your EMT class. The pain felt like a pressure. It was brought on by exertion. It radiated to the left arm and through to the back. Sometimes, in your EMT skills stations, we would get fancy and have it begin at rest and radiate to the jaw. Just trying to keep you on your toes after all.. All this stuff is good to know. But we may have done you a disservice. You may be walking around with the idea that you can do a quick OPQRST and a SAMPLE and walk away with a fairly good feel for whether or not your patient is having a heart attack. You may be dead wrong.. What we may not have told you was that a large percentage of your patients suffering acute myocardial infarction wont look anything like this. Atypical cardiac chest pain, those folks who have heart attacks but dont quite feel like theyre supposed to feel, are actually very common. Common enough that we may need to think of a new name for them. Research says that ...
universal definition of myocardial infarction Table of Contents Abbreviations and acronyms Definition of myocardial infarction Introduction Pathological characteristics of myocardial ischaemia ... European Heart Journal, Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., White, Harvey D., Thygesen, Kristian, Alpert, Joseph S., White, Harvey D., ... ...
universal definition of myocardial infarction Table of Contents Abbreviations and acronyms Definition of myocardial infarction Introduction Pathological characteristics of myocardial ischaemia ... European Heart Journal, Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., White, Harvey D., Thygesen, Kristian, Alpert, Joseph S., White, Harvey D., ... ...
Cardiovascular Disease on Deakin Rural Health | Access and Outcomes to Cardiovascular Disease Services in Rural and Remote Australia In a cardiac emergency…
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Creatine is a naturally occurring chemical that can provide a major boost to your health and fitness routine. Keep reading for five great reasons to make creatine a part of your supplement routine. Learn more at eVitamins México.
Much has been made of Creatine and Side Effects. The question is whether there are enough negative effects to outweight the fact that studies show that creatine helps build muscle.
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Hi Patrick, Here is an interesting article, worth a look if you havent seen it before. Creatine: How Much Should You Be Taking? | Arnold
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At present, the risk of myocardial damage by endurance exercise is under debate because of reports on exercise-associated increases in cardiac biomarkers troponin and B-type natriuretic peptide (BNP); these markers are typically elevated in patients with acute myocardial infarction and chronic heart failure, respectively. Exercise-associated elevations of cardiac biomarkers can be present in elite and in recreational athletes, especially after prolonged and strenuous endurance exercise bouts (e.g., marathon and ultratriathlon). However, in contrast to cardiac patients, it is still unclear if the exercise-associated appearance or increase in cardiac biomarkers in obviously healthy athletes represents clinically significant cardiac insult or is indeed part of the physiological response to endurance exercise. In addition, elevations in cardiac biomarkers in athletes after exercise may generate difficulties for clinicians in terms of differential diagnosis and may result in inappropriate ...
Background: Excess alcohol consumption can lead to myocardial dysfunction. However, whether novel cardiac biomarkers tests can detect subclinical myocardial damage and wall stress in asymptomatic populations exposed to alcohol is currently unknown.. Objective: To characterize the association of alcohol consumption with subclinical myocardial damage, as assessed by a novel highly sensitive assay for cardiac troponin T (hs-cTnT) and wall stress, as assessed by N-terminal pro-brain natriuretic peptide (NT-proBNP).. Methods: Using data from the community-based ARIC Study we examined the cross-sectional association of categories of self-reported alcohol consumption with cardiac biomarkers among 10,381 individuals without cardiovascular disease (1990-92). We also examined the prospective association of alcohol consumption with 6-year change in cardiac biomarkers in a subset of participants (n=8,972 for hs-cTnT and n=9,060 for NT-proBNP), who had each biomarker measured at two time points. Incident ...
Percutaneous coronary intervention (PCI) is associated with a 15% to 35% incidence of periprocedural myocardial injury (PMI). Its spectrum ranges from obvious clinical myocardial infarction to subtle myocardial injury manifested by mild rises in cardiac enzymes. Even in the latter case, the resulting myocardial damage is clinically important, as multiple studies have consistently demonstrated that PMI is associated with increased long-term mortality with a graded risk related to the extent of creatine kinase-MB or cardiac troponin elevation. Despite extensive basic and clinical research and multiple therapeutic approaches, its incidence has not substantially decreased over the last 2 decades. Two patterns of PMI have been recognized by magnetic resonance imaging. Type I is near the intervention site consequent to side branch occlusion, and type II is in the downstream territory of the treated artery where perfusion is compromised mainly due to structural and functional microvascular dysfunction ...
Press Release issued Jan 19, 2015: Cardiac Marker Analyzer, also known as Cardiac Reader Systems, provides high point-of-care testing solutions for the diagnosis of myocardial infarction and other cardiac-related diseases. It performs all cardiac monitoring tests, such as myoglobin and cardiac troponin tests, through immunochromatographic assays. A Cardiac Marker Analyzer increases its efficacy and accuracy with special features, such as software, which provides an internal standard to diagnostic procedures and built in LCD displays for the visualization of practices. Cardiac Marker Analyzers are important for the prevention of the misdiagnoses of cardiac conditions.
Press Release issued Apr 25, 2014: Cardiovascular diseases are leading cause of morbidity and mortality globally. Biomarkers are generally used as an indicator forparticular diseases such as rheumatic and congenital heart diseases and cardiac arrhythmia. Cardiac biomarkers are measurable and quantifiable biological parameters. These are specifically used to check the presence or severity of cardiovascular diseases. Cardiac biomarkers are the substances that are released into blood when heart is damaged. These biomarkers are also used for diagnosing and monitoring diseases such as coronary syndrome or cardiac ischemia. The symptoms of these diseases includes chest pain, shortness of breath and nausea that ultimately leads to heart attack or angina. Cardiac biomarker tests helps to detect presence of coronary syndrome and cardiac ischemia to evaluate its severity and diagnosis.
Cardiac markers or cardiac enzymes are proteins that leak out of injured myocardial cells through their damaged cell membranes into the bloodstream. The markers most widely used in detection of MI are the enzyme creatine kinase and cardiac troponins T and I as they are more specific for myocardial injury. The cardiac troponins T and I which are released within 4-6 hours of an attack of MI and remain elevated for up to 2 weeks, have nearly complete tissue specificity and are now the preferred markers for assessing myocardial damage. The diagnosis of myocardial infarction requires two out of three components (history, ECG, and enzymes). When damage to the heart occurs, levels of cardiac markers rise over time.. ...
The early determination of whether a patient presenting with chest pain is truly having an MI has 2 important ramifications, only 1 of which is addressed by Puleo and colleagues. The authors rightly point out that resources are wasted when patients without MIs are placed in units designed to care for patients with MIs. Another important aspect of an early and accurate diagnosis of infarction is to allow for early treatment with thrombolytic drugs. This study clearly shows that CK-MB subforms detect MI within 6 hours after the onset of symptoms. It is clear that patients presenting with "big-bang" infarctions (i.e., significant ST-segment elevation) will need to receive thrombolytic drugs as early as possible and that in this group of patients an elevation of CK-MB subform would be of little value. The management of patients with a good history and equivocal electrocardiographic changes can be more difficult. Thus, although providing valuable information on the sensitivity and specificity of ...
It is commonly assumed that creatine kinase (CK) activity in plasma is related to a state of an inflammatory response in 24-48 h and also has shown
Although acute myocardial infarction can be diagnosed on the basis of clinical history, electrocardiographic (ECG) findings, and abnormalities of creatine kinase (CK) and lactate dehydrogenase (LDH) enzyme levels, measurement of cardiac enzyme levels
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Cardiac enzymes are sometimes called heart damage markers because they are released into the bloodstream when heart muscle cells are damaged. ...
Cardiac enzymes are sometimes called heart damage markers because they are released into the bloodstream when heart muscle cells are damaged. ...
Background Glycated hemoglobin (HbA1c) predicts clinical cardiovascular disease or cardiovascular mortality. However, the relationship between HbA1c and myocardial injury following elective percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (DM) has not been investigated. Objectives The study sought to assess the relationship between HbA1c and myocardial injury following elective PCI in patients with type 2 DM. Methods We studied a cohort of consecutive 994 diabetic patients with coronary artery disease (CAD) undergoing elective PCI. Periprocedural myocardial injury was evaluated by analysis of troponin I (cTnI). The association between preprocedural HbA1c levels and the peak values of cTnI within 24 hours after PCI was evaluated. Results Peak postprocedural cTnI |1×upper limit of normal (ULN), |3×ULN and |5×ULN were detected in 543 (54.6%), 337 (33.9%) and 245 (24.6%) respectively. In the multivariate model, higher HbA1c levels were associated with less risk of
Free Online Library: Creatine kinase isoenzyme MB (CKMB) controversy: perimortal tissue acidosis may explain the absence of CKMB in myocardium at autopsy.(Technical Briefs) by Clinical Chemistry; Cardiac patients Cardiology Enzymes Medical research Medicine, Experimental

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... evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging ... Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance ... Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle ... training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and ...
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Multicenter Registry on Inflammatory Myositis From the Rheumatology Society in Madrid, Spain: Descriptive Analysis |...Multicenter Registry on Inflammatory Myositis From the Rheumatology Society in Madrid, Spain: Descriptive Analysis |...

That patient was diagnosed with systemic sclerosis and had muscle weakness and a baseline creatine kinase (CK) level of 748IU/L ... In all, 25% of the patients had complications in the form of serious infections, mainly lower respiratory tract infections (63 ... 0.16MB).. Cumulative and current treatment.. Anti-TNFα, anti-tumor necrosis factor α; AZA, azathioprine; CP, cyclophosphamide; ... CAM, cancer-associated myositis; CK, creatine kinase; DM, idiopathic dermatomyositis; ILD, interstitial lung disease; JM, ...
more infohttp://reumatologiaclinica.org/en/multicenter-registry-on-inflammatory-myositis/articulo/S2173574317301235/

Aptamer-based fluorometric lateral flow assay for creatine kinase MB | SpringerLinkAptamer-based fluorometric lateral flow assay for creatine kinase MB | SpringerLink

A group of aptamers possessing high specificity and affinity for creatine kinase MB (CKMB) was obtained by magnetic systematic ... They form a well suited pair for CKMB binding. By using fluorescent microspheres, an aptamer-based lateral flow assay was ... A group of aptamers possessing high specificity and affinity for creatine kinase MB (CKMB) was obtained by magnetic systematic ... Roberts R, Sobel BE, Parker CW (1976) Radioimmunoassay for creatine kinase isoenzymes. Science 194(4267):855-857CrossRefPubMed ...
more infohttps://link.springer.com/article/10.1007%2Fs00604-018-2905-4

Analysis of troponin I levels after spontaneous implantable cardioverter defibrillator shocks.Analysis of troponin I levels after spontaneous implantable cardioverter defibrillator shocks.

Creatine Kinase / blood. Creatine Kinase, MB Form. Defibrillators, Implantable / adverse effects*. Female. Humans. Isoenzymes ... 0/Isoenzymes; 0/Troponin I; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form ... 25299619 - General immune status and oral microbiology in patients with different forms of periodo.... 21140239 - Prior and new ...
more infohttp://www.biomedsearch.com/nih/Analysis-troponin-levels-after-spontaneous/11900289.html

Clinical, angiographic, and intravascular ultrasound characteristics of early saphenous vein graft failure.Clinical, angiographic, and intravascular ultrasound characteristics of early saphenous vein graft failure.

Creatine Kinase / blood. Creatine Kinase, MB Form. Female. Graft Occlusion, Vascular / diagnosis*, etiology*, physiopathology. ... 0/Biological Markers; 0/Isoenzymes; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form ... 36.1%, p , 0.001). After PCI, 20.6% of early and 30.6% of late failure lesions had creatine kinase-myocardial band (CK-MB) ...
more infohttp://www.biomedsearch.com/nih/Clinical-angiographic-intravascular-ultrasound-characteristics/15234406.html

How are creatine kinase-MB (CK-MB) isoforms used as cardiac markers?How are creatine kinase-MB (CK-MB) isoforms used as cardiac markers?

CK-MB2 is the tissue form and initi... more ... Laboratory determination of CK-MB actually represents the ... The CK-MB isoenzyme exists as 2 isoforms: CK-MB1 and CK-MB2. ... How are creatine kinase-MB (CK-MB) isoforms used as cardiac ... How are creatine kinase-MB (CK-MB) isoforms used as cardiac markers?) and How are creatine kinase-MB (CK-MB) isoforms used as ... Use of a rapid assay of subforms of creatine kinase-MB to diagnose or rule out acute myocardial infarction. N Engl J Med. 1994 ...
more infohttps://www.medscape.com/answers/811905-55930/how-are-creatine-kinase-mb-ck-mb-isoforms-used-as-cardiac-markers

Creatine Kinase MB (Blood) -  Health Encyclopedia - University of Rochester Medical CenterCreatine Kinase MB (Blood) - Health Encyclopedia - University of Rochester Medical Center

It is called CK-MB. Your body makes 3 forms of CK, including CK-MB. CK is found in the heart, muscles, and other organs. These ... Creatine Kinase MB (Blood). Does this test have other names?. CK-MB ... This test measures the amount of an isoenzyme of creatine kinase (CK) in your blood. ... Levels of CK-MB do not rise in your blood within the first 4 to 6 hours after a heart attack. You may need to have repeated ...
more infohttps://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=creatine_kinase_mb

Creatine kinase - WikipediaCreatine kinase - Wikipedia

... there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter ... Skeletal muscle expresses CK-MM (98%) and low levels of CK-MB (1%). The myocardium (heart muscle), in contrast, expresses CK-MM ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ...
more infohttps://en.wikipedia.org/wiki/Creatine_kinase

Patent US7732199 - Process for making transplantable cardiomyocytes from human embryonic stem cells - Google PatentsPatent US7732199 - Process for making transplantable cardiomyocytes from human embryonic stem cells - Google Patents

creatine kinase MB (CK-MB) and myoglobin, which are elevated in serum following myocardial infarction Other markers that may be ... Included are compounds capable of forming a high energy phosphate bond (such as creatine); an acyl group carrier molecule (such ... Creatine kinase MB (CK-MB) and myoglobin were also detected by immunostaining of the hES-derived cardiomyocytes, costaining ... creatine kinase MB (CK-MB), myoglobin, or atrial natriuretic factor (AN F). ...
more infohttp://www.google.com/patents/US7732199?dq=5958006

Creatine Kinase MB (Blood) - AHealthyMe - Blue Cross Blue Shield of MassachusettsCreatine Kinase MB (Blood) - AHealthyMe - Blue Cross Blue Shield of Massachusetts

A certain form of this enzyme can help find out whether youre having a heart attack. ... This test measures the amount of the enzyme creatine kinase in your blood. ... Creatine Kinase MB (Blood). Does this test have other names?. CK-MB ... This test measures the amount of an isoenzyme of creatine kinase (CK) in your blood. It is called CK-MB. ...
more infohttp://www.ahealthyme.com/Conditions/Neuroscience/167,creatine_kinase_mb

Creatine Kinase MB (Blood) - AHealthyMe - Blue Cross Blue Shield of MassachusettsCreatine Kinase MB (Blood) - AHealthyMe - Blue Cross Blue Shield of Massachusetts

A certain form of this enzyme can help find out whether youre having a heart attack. ... This test measures the amount of the enzyme creatine kinase in your blood. ... Creatine Kinase MB (Blood). Does this test have other names?. CK-MB ... This test measures the amount of an isoenzyme of creatine kinase (CK) in your blood. It is called CK-MB. ...
more infohttp://www.ahealthyme.com/Library/Wellness/DiseasesConditions/167,creatine_kinase_mb

Patrick W Serruyss Research on Drug-Eluting Stents
     | CureHunterPatrick W Serruys's Research on Drug-Eluting Stents | CureHunter

MB Form Creatine KinaseIBA 07/2015 - 11/2005. 3. AdenosineFDA LinkGeneric 05/2015 - 02/2004. ... Creatine Kinase (Creatine Phosphokinase)IBA 07/2015 - 05/2004. 4. 1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF ...
more infohttp://www.curehunter.com/public/authorSummary-Serruys,%20Patrick%20W.do?keywordId=D054855

Hyperthyroidism - WikipediaHyperthyroidism - Wikipedia

In hyperthyroidism CK-MB (Creatine kinase) is usually elevated. In overt primary hyperthyroidism, TSH levels are low and T4 and ... This form of hyperthyroidism usually corrects itself within weeks or months without the need for treatment. A struma ovarii is ... Anti-thyroid drugs for cats are available in both pill form and in a topical gel, that is applied using a finger cot to the ... Surgery (thyroidectomy to remove the whole thyroid or a part of it) is not extensively used because most common forms of ...
more infohttps://en.wikipedia.org/wiki/Hyperthyroidism

Ranolazine Loading to Prevent PCI-induced Myocardial Injury - Tabular View - ClinicalTrials.govRanolazine Loading to Prevent PCI-induced Myocardial Injury - Tabular View - ClinicalTrials.gov

... creatine kinase-MB, myoglobin, and troponin I). *Able to understand and willing to sign the informed consent form ... Changes after percutaneous coronary intervention in absolute values of creatine kinase, creatine kinase-MB, myoglobin, and ... Occurrence of peri-procedural myocardial infarction (i.e. creatine kinase-MB,3 times the upper reference limit) ... Normal baseline values of markers of myocardial damage (creatine kinase, ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT01491061?show_rss=Y&sel_rss=mod14

Detection of Ischaemic Myocardial Damage during Balloon Coronary Angioplasty: Role of Creatine Kinase MB Isoform Ratios |...Detection of Ischaemic Myocardial Damage during Balloon Coronary Angioplasty: Role of Creatine Kinase MB Isoform Ratios |...

Production of rat soluble and membrane-bound catechol O -methyltransferase forms from bifunctional mRNAs Biochem J (December, ... Detection of Ischaemic Myocardial Damage during Balloon Coronary Angioplasty: Role of Creatine Kinase MB Isoform Ratios M ... Role of Creatine Kinase MB Isoform Ratios. Clin Sci (Lond) 1 March 1993; 84 (s28): 23P. doi: https://doi.org/10.1042/cs084023Pa ...
more infohttps://portlandpress.com/clinsci/article-abstract/84/s28/23P/104566/Detection-of-Ischaemic-Myocardial-Damage-during?redirectedFrom=fulltext

What are the signs of elevated creatine kinase? | Reference.comWhat are the signs of elevated creatine kinase? | Reference.com

Signs and symptoms that typically accompany an elevated creatine kinase include cardiac symptoms such as chest pain, breathing ... CK-MM is a form of creatine kinase found in the heart and skeletal muscles, whereas CK-MB is present in the heart. The type of ... creatine kinase located in the brain is called CK-BB.. A higher creatine kinase level usually manifests a few hours after a ... The heart, brain and skeletal muscles are the parts of the body that primarily contain the enzyme creatine kinase, states ...
more infohttps://www.reference.com/health/signs-elevated-creatine-kinase-78f2f8f94280f3ed

The creatine kinase system and pleiotropic effects of creatine | SpringerLinkThe creatine kinase system and pleiotropic effects of creatine | SpringerLink

... are based mostly on the functions of the enzyme creatine kinase (CK) and its high-energy product phosphocreatine (PCr). ... form homo-dimers or hetero-dimers, e.g. MM-CK in skeletal muscle, MM-, MB- and BB-CK in heart, or BB-CK in brain, kidney, ... Molecular structure and function of mitochondrial creatine kinases. In: Vial C (ed), Uversky VN (series ed) Creatine kinase- ... High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in ...
more infohttps://link.springer.com/article/10.1007%2Fs00726-011-0877-3

Diltiazem Reinfarction Study - American College of CardiologyDiltiazem Reinfarction Study - American College of Cardiology

Keywords: Diltiazem, Atrioventricular Block, Myocardial Infarction, Creatine Kinase, MB Form, Ticlopidine, Calcium Channel ... Non-Q-wave MI (elevated CK-MB and either ischemic pain for 30 minutes or ST-segment deviation [elevation or depression ≥1 mm or ... Reinfarction at 14 days (defined as increase of 50% or more in CK-MB above preceding baseline level in at least two samples ... Postinfarction angina of any severity, refractory angina not associated with abnormal CK-MB elevation, death within 14 days of ...
more infohttp://www.acc.org/latest-in-cardiology/clinical-trials/2010/02/23/19/01/diltiazem-reinfarction-study

Creatine kinase - WikipediaCreatine kinase - Wikipedia

... there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. The functional entity of the latter ... Skeletal muscle expresses CK-MM (98%) and low levels of CK-MB (1%). The myocardium (heart muscle), in contrast, expresses CK-MM ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ...
more infohttps://en.m.wikipedia.org/wiki/Creatine_kinase

Creatine kinase - wikidocCreatine kinase - wikidoc

In addition to those, there are two mitochondrial creatine kinases, the ubiquitous and sarcomeric form. ... CK and CK-MB Elevation During Pregnancy. *In contrast to troponin, the utility of CK-MB for the diagnosis of AMI in pregnancy ... Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2.7.3.2) expressed ... Thus Creatine Kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker ...
more infohttp://www.wikidoc.org/index.php/Creatine_kinase

A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary...A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary...

Change from baseline in Creatine Kinase-Myocardial Band (CK-MB) after PCI [ Time Frame: from baseline to 24 hours post PCI ]. * ... Change form baseline in Growth Differentiation Factor 15 (GDF-15) at 120 days post PCI [ Time Frame: from baseline to Day 120 ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01327183?term=heart+attack&lup_s=04%2F23%2F2014&lup_d=14&show_rss=Y&sel_rss=mod14
  • The first X-ray structures of Creatine Kinases, those of both mitochondrial types (sarcomeric-mtCK (in 1996) and ubiquitous mtCK (in 2000), forming highly four-symmetrical octameric structures, as well as that of cytosolic brain-type BB-CK (at 1.4 Angstoms, in 1999), forming symmetric dimers, have been solved by the T. Wallimann and W. Kabsch groups at ETH-Zürich and at MPI-Heidelberg. (wikipedia.org)
  • PCr is not only an energy buffer but also a cellular transport form of energy between subcellular sites of energy (ATP) production (mitochondria and glycolysis) and those of energy utilization (ATPases). (wikipedia.org)
  • Creatine (Cr) has emerged as a safe nutritional supplement not only to increase muscle mass and performance, prevent disease-induced muscle atrophy and improve rehabilitation, but also to strengthen cellular energetics in general (see Salomons and Wyss 2007). (springer.com)
  • 2008 ). Although Cr effects are likely due to pleiotropic cellular functions, its main role is in the creatine kinase (CK/PCr) system for temporal and spatial energy buffering. (springer.com)
  • Levels of CK-MB do not rise in your blood within the first 4 to 6 hours after a heart attack. (rochester.edu)
  • Higher levels of CK-MB may mean that you have had a heart attack or have other heart problems. (rochester.edu)
  • Higher levels of CK-MB may also mean more of the heart was damaged in the attack. (rochester.edu)
  • Of the 61 patients with AMI, 35 (57%) had a normal creatine kinase isoenzyme ratio at the time of presentation to the ED, but had high levels of circulating MPA (13.3). (umassmed.edu)
  • Reinfarction at 14 days (defined as increase of 50% or more in CK-MB above preceding baseline level in at least two samples taken a minimum of 4 hrs apart within a 24 hr interval and an absolute value of 14 IU/L or greater in1 or more of these samples). (acc.org)
  • Higher CK-MB may point more directly to heart damage. (rochester.edu)
  • This test is more commonly used than CK-MB because it more specifically shows heart damage. (rochester.edu)
  • A higher creatine kinase level usually manifests a few hours after a heart attack when the heart muscle cells start to die, says Healthgrades. (reference.com)
  • This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/ ) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage ). (pubmedcentralcanada.ca)
  • Lai XH, Liang RL, Liu TC, Dong ZN, Wu YS, Li LH (2016) A fluorescence immunochromatographic assay using europium (III) chelate microparticles for rapid, quantitative and sensitive detection of creatine kinase MB. (springer.com)
  • The bound cytosolic CK accepts the PCr shuttled through the cell and uses ADP to regenerate ATP, which can then be used as energy source by the ATPases (CK is associated intimately with the ATPases, forming a functionally coupled microcompartment). (wikipedia.org)