A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
A form of creatine kinase found in the BRAIN.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
An isoenzyme of creatine kinase found in the MUSCLE.
A form of creatine kinase found in the MITOCHONDRIA.
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.
An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC
Contractile tissue that produces movement in animals.
Agents that inhibit PROTEIN KINASES.
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Production of recombinant human creatine kinase (r-hCK) isozymes by tandem repeat expression of M and B genes and characterization of r-hCK-MB. (1/46)

BACKGROUND: Serum creatine kinase-MB isoenzyme (CK-MB) is widely used as a marker of myocardial injury. We prepared recombinant human CK (r-hCK) MB isoenzyme and examined its potential for use as a control material for assay of CK-MB in serum. METHODS: cDNAs encoding CK-M and CK-B subunits were inserted into the same plasmid vector, followed by transformation of Escherichia coli. The resulting three types of CK isoenzymes were purified by conventional chromatography. RESULTS: The ratio of MB to MM to BB was 50:40:10 on the basis of CK activity. Highly purified CK-MB with a specific activity of 533 U/mg was produced in a yield of 5.7 mg/g of packed cells. Purified r-hCK-MB had the isoelectric point (pI 5.3) and molecular size (46 kDa for the subunit) of native CK-MB. Its immunoreactivity in an ELISA using antibody against native heart enzyme was similar to that of cardiac CK-MB. The r-hCK-MB retained >90% activity for at least 4 months at 11 degrees C in a delipidated serum matrix in a liquid form at a concentration of 118 U/L. CONCLUSIONS: r-hCK-MB shows key properties of the native cardiac isoenzyme and may be useful as a control and calibrator for serum assays of CK-MB.  (+info)

Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia. (2/46)

To identify new markers of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (ALL), gene expression of leukemic cells obtained from 4 patients with newly diagnosed ALL was compared with that of normal CD19(+)CD10(+) B-cell progenitors obtained from 2 healthy donors. By cDNA array analysis, 334 of 4132 genes studied were expressed 1.5- to 5.8-fold higher in leukemic cells relative to both normal samples; 238 of these genes were also overexpressed in the leukemic cell line RS4;11. Nine genes were selected among the 274 overexpressed in at least 2 leukemic samples, and expression of the encoded proteins was measured by flow cytometry. Two proteins (caldesmon and myeloid nuclear differentiation antigen) were only weakly expressed in leukemic cells despite strong hybridization signals in the array. By contrast, 7 proteins (CD58, creatine kinase B, ninjurin1, Ref1, calpastatin, HDJ-2, and annexin VI) were expressed in B-lineage ALL cells at higher levels than in normal CD19(+)CD10(+) B-cell progenitors (P <.05 in all comparisons). CD58 was chosen for further analysis because of its abundant and prevalent overexpression. An anti-CD58 antibody identified residual leukemic cells (0.01% to 1.13%; median, 0.03%) in 9 of 104 bone marrow samples from children with ALL in clinical remission. MRD estimates by CD58 staining correlated well with those of polymerase chain reaction amplification of immunoglobulin genes. These results indicate that studies of gene expression with cDNA arrays can aid the discovery of leukemia markers. (Blood. 2001;97:2115-2120)  (+info)

Comparisons of the effects of tamoxifen, toremifene and raloxifene on enzyme induction and gene expression in the ovariectomised rat uterus. (3/46)

This study compares the actions of oestradiol, tamoxifen, toremifene and raloxifene on enzyme and gene expression in uterine tissues of ovariectomised rats over 72 h. The time-course for the induction of ornithine decarboxylase by the compounds showed a rapid biphasic response, while for creatine kinase brain type (BB) there was a continued increase over 72 h. The efficacy of induction showed that, with both markers, oestradiol gave the highest induction level, followed by tamoxifen or toremifene and then raloxifene. RT-PCR demonstrated that all compounds decreased oestrogen receptor (ER) alpha, ERbeta and ERbeta2 gene expression, 8-24 h after the first dose, suggesting that down-regulation of ER is not the primary cause of the difference in efficacy between these compounds. Using cDNA arrays, expression of 512 genes was examined in the uteri of oestradiol- or tamoxifen-treated rats. Both compounds resulted in the up-regulation of heat-shock protein 27, telomerase-associated protein 1 and secretin. However, most surprising was the marked down-regulation of Wilms' tumour and retinoblastoma genes. We speculate that this may result in a loss of regulation of the transition from the G1 to the S phase in the cell cycle and may make cells more vulnerable to the carcinogenic effects of tamoxifen in this tissue.  (+info)

Effect of weight bearing on recovery from nerve injury in skeletal muscle. (4/46)

We examined the effect of weight bearing (WB) on muscle recovery after nerve injury. Rats were housed in individual cages for 2 wk under WB or hindlimb suspension (HS) after being subjected to sciatic nerve compression for 1 wk. Sham operated on rats served as controls (sham group). We used 31P- and 19F-nuclear magnetic resonance spectroscopy combined with histochemical, physiological, and biochemical techniques to assess the outcome in the three groups. Creatine kinase-BB (CK-BB) mRNA levels expression, CK activity, and type I fiber density in the WB group were elevated compared with those in the HS group. In addition, sciatic functional index, tetanic tension, energy state, and local circulation dynamics of the WB group were greater than those of the HS group. These results suggested that WB plays an important role in muscle regeneration, inhibits the reduction of CK activity, and facilitates the activation of neural recovery, energy state, and local circulation dynamics.  (+info)

Expression of brain subtype creatine kinase in the zebrafish embryo. (5/46)

Creatine kinases (CK) play crucial roles in intracellular energy transfer. We have isolated a cDNA from zebrafish embryos, which encodes a CK highly related to the mammalian brain subtype creatine kinase (BCK). The bck mRNA is expressed maternally in the zebrafish embryo and transcripts are distributed uniformly in blastula and gastrula stages. Expression becomes restricted to the prechordal plate and the nervous system during subsequent somitogenesis stages. bck transcripts are abundant in primary neurons in the developing central nervous system of the 1-day-old embryo. While some bck expression persists in the hindbrain, expression vanishes in the spinal cord of the 2-day-old embryo. In summary, the expression pattern of bck is highly dynamic and suggests a role for bck during gastrulation and neuronal differentiation.  (+info)

Postoperative patterns and kinetics of cTnI, cTnT, CK-MB-activity and CK-activity after elective aortic valve replacement. (6/46)

OBJECTIVES: The aim of this prospective study was to evaluate postoperative kinetics of four different biochemical ischaemic markers after elective aortic valve replacement (AVR). Additionally, pre-, peri- and postoperative data were analysed in order to identify factors with possible impact on the postoperative release of the selected enzymes. DESIGN: Forty patients (14 males, 26 females, aged 70 +/- 11 years; EF = 54 +/- 18% [mean +/- SD]) undergoing elective AVR were prospectively included in this study. For all patients, serum concentrations of cTnI, cTnT, and serum activities of CK-MB and CK were measured preoperatively as well as 0, 6, 12, 24, 48 and 120 hours after removal of the aortic cross-clamp. Clinical data were assessed in all patients and correlated with postoperative enzyme patterns. RESULTS: There were no major complications. Preoperatively, all patients showed enzyme values in the normal range whereas the four ischaemic markers reached higher values postoperatively. cTnI reached its maximum values 24 hours (XMed = 2.35 micrograms/L, 95%-CI [2.0, 3.3]) and cTnT 48 hours after the operation (XMed = 0.239 microgram/L, 95%-CI [0.174, 0.283]). Typical biphasic release kinetics could be demonstrated for cTnT. There was a high linear correlation between cTnI and cTnT at all sampling times. In contrast, a high linear correlation between cTnI, cTnT, and CK-MB-activity was only found 48 hours after aortic unclamping. cTnI nearly was in normal range 120 h postoperatively (XMed = 0.5 microgram/L, 95%-CI [0.2, 0.6]), whereas cTnT still remained pathologically elevated (XMed = 0.223 microgram/L, 95%-CI [0.137, 0.299]). No linear correlation was found between maximum values of the ischaemic markers postoperatively and age, gender, body surface area, ejection fraction, LV-hypertrophy, operating time, ECC time, time of cardiac arrest, lowest body temperature, perfusion pressure, cardioplegia volume, reperfusion time, postoperative septiformic circulatory instability, or ventilation time. CONCLUSIONS: All four ischaemic markers showed individual peak characteristics and kinetics after uncomplicated AVR. In contrast to previous findings, aortic cross-clamping time had no detectable impact on postoperative peak patterns of any ischaemic marker.  (+info)

Two specific markers for neural differentiation of embryonal carcinoma cells. (7/46)

Two multipotential embryonal carcinoma (EC) cell lines, 1003 and 1009, can be induced to form preferentially neural derivatives in vitro. Synthesis of specific proteins during neural differentiation was followed by two-dimensional gel electrophoresis. The comparison of protein patterns obtained with neural and non-neural derivatives of these EC cell lines indicates that two changes are specific for the neural pathway: (i) the appearance of a new beta-tubulin isoform and (ii) the accumulation of the brain isozyme of creatine phosphokinase already present in small amounts in EC stem cells. These changes were found to take place early in the course of differentiation and to occur even when neurite outgrowth was prevented.  (+info)

Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation. (8/46)

Transcription and accumulation of brain-type creatine kinase (CKB) mRNA and its protein was examined during postnatal development of rat brain cerebellum, the brain region containing highest CKB mRNA in the adult. CKB protein was extremely low at day 1, increased about 10-fold until week 4 and remained constant until week 10. This time course was paralleled by cerebellar CKB mRNA, which was also extremely low at day 1 and increased 5-fold during the first 3 weeks and then remained constant. High levels of CKB protein were also detected in cultured primary cerebellar granular neurons. Nuclear run-on assays directly showed that CKB mRNA accumulation during postnatal cerebellar development was due to increased transcription. When compared with cerebrum and whole brain, cerebellar CKB mRNA accumulation during postnatal development was temporally delayed. Analysis of myocyte enhancer factor (MEF)-2 and Sp1, factors known to initiate or sustain CKB transcription in tissues other than brain, revealed that MEF-2 in cerebellum was low at week 1 but increased 3.5-fold by week 7, while Sp1 remained unchanged. The increase in CKB protein during cerebellar postnatal development was coincident with that of the ubiquitous mitochondrial CK protein and mRNA, indicating that a functional phosphocreatine energy shuttle probably exists for efficient ATP regeneration in the cerebellum. This should be beneficial for the many energy-demanding requirements during cerebellar development, as indicated by the observed temporal co-expression of CKB with myelin basic protein, which is involved in axon myelination by oligodendrocytes.  (+info)

There are several different types of brain injuries that can occur, including:

1. Concussions: A concussion is a type of mild traumatic brain injury that occurs when the brain is jolted or shaken, often due to a blow to the head.
2. Contusions: A contusion is a bruise on the brain that can occur when the brain is struck by an object, such as during a car accident.
3. Coup-contrecoup injuries: This type of injury occurs when the brain is injured as a result of the force of the body striking another object, such as during a fall.
4. Penetrating injuries: A penetrating injury occurs when an object pierces the brain, such as during a gunshot wound or stab injury.
5. Blast injuries: This type of injury occurs when the brain is exposed to a sudden and explosive force, such as during a bombing.

The symptoms of brain injuries can vary depending on the severity of the injury and the location of the damage in the brain. Some common symptoms include:

* Headaches
* Dizziness or loss of balance
* Confusion or disorientation
* Memory loss or difficulty with concentration
* Slurred speech or difficulty with communication
* Vision problems, such as blurred vision or double vision
* Sleep disturbances
* Mood changes, such as irritability or depression
* Personality changes
* Difficulty with coordination and balance

In some cases, brain injuries can be treated with medication, physical therapy, and other forms of rehabilitation. However, in more severe cases, the damage may be permanent and long-lasting. It is important to seek medical attention immediately if symptoms persist or worsen over time.

Cytosolic BB-CK, as well as muscle-type MM-CK both form banana-shaped symmetric dimers, with one catalytic active site in each ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ... Thus creatine kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC expressed ...
Macro-CK type 1 is a complex formed by one of the creatine kinase isoenzyme types, typically CK-BB, and antibodies; typically ... Macro-creatine kinase (macro-CK) is a macroenzyme, an enzyme of high molecular weight and prolonged half-life found in human ... Zhang, L; Han, F; Liu, X; Xie, C; Tian, K; Bi, Q; Hao, M; Mu, X (6 August 2020). "Macro creatine kinase in an asymptomatic ... Horino, T; Ichii, O; Ode-Hamada, K; Terada, Y (1 September 2017). "Macromolecular creatine kinase type 1 in immune-mediated ...
Creatine+Kinase,+BB+Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKB genome location and ... Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein ... Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly ... phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in ...
... measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), brain (CK-BB) and skeletal ... Various forms of family-based treatment have been proven to work in the treatment of adolescent AN including conjoint family ... The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which the person loses a significant amount of weight and ... Schema-Focused Therapy (a form of CBT) was developed by Dr. Jeffrey Young and is effective in helping patients identify origins ...
It has been inferred that levels of CSF neuron-specific enolase, serum NSE, and creatine kinase (type BB) are indicative in the ... In humans there are three subunits of enolase, α, β, and γ, each encoded by a separate gene that can combine to form five ... pyruvate kinase, creatine kinase, and lactate dehydrogenase). The same study showed that the fastest rate of tumor growth ... In human alpha enolase, the two subunits are antiparallel in orientation so that Glu20 of one subunit forms an ionic bond with ...
... itself can be phosphorylated by creatine kinase to form phosphocreatine, which is used as an energy buffer in skeletal ... need phosphocreatine and creatine and indeed kidneys express significant amounts of creatine kinases (BB-CK and u-mtCK ... A cyclic form of creatine, called creatinine, exists in equilibrium with its tautomer and with creatine. Creatine is ... Persky AM, Rawson ES (2007). "Safety of creatine supplementation". Creatine and Creatine Kinase in Health and Disease. ...
ISBN 978-0-444-88232-5. Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange ... This competition led to fast growth of new forms and the fast evolution of IC. A challenge that needs to be overcome in the ... Firstly, CK- MM was eluted, then CK-MB, followed by CK-BB. Therefore, the isoenzymes found in each sample could be used to ... Therefore, IC has been employed in drugs in the form of tablets and capsules in order to determine the amount of drug dissolve ...
... creatine kinase MeSH D08.811.913.696.640.150.500 - creatine kinase, bb form MeSH D08.811.913.696.640.150.625 - creatine kinase ... creatine kinase, mitochondrial form MeSH D08.811.913.696.640.150.875 - creatine kinase, mm form MeSH D08.811.913.696.645 - ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ...
... protein kinase A). AMPK is a heterotrimeric protein complex that is formed by α, β, and γ subunits. Each of these three ... Thomson DM, Porter BB, Tall JH, Kim HJ, Barrow JR, Winder WW (January 2007). "Skeletal muscle and heart LKB1 deficiency causes ... expression in skeletal muscle in response to creatine depletion. PGC-1α is a transcriptional regulator for genes involved in ... liver kinase B1 (LKB1), which works in a complex with STRAD and MO25, Calcium/calmodulin-dependent protein kinase kinase II-( ...
Protein kinase B (Akt) is thought to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. Akt itself is ... Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, ... Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable ... both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular stress. Fasting can ...
Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE (March 1999). "Actions of caffeine in the brain with special reference to ... A use of caffeine in this form is said to improve mental alertness. These tablets are commonly used by students studying for ... Tarnopolsky MA (2010). "Caffeine and creatine use in sport". Annals of Nutrition & Metabolism. 57 (Suppl 2): 1-8. doi:10.1159/ ... As a competitive nonselective phosphodiesterase inhibitor, caffeine raises intracellular cyclic AMP, activates protein kinase A ...
Creatine Kinase, BB Form / analysis Actions. * Search in PubMed * Search in MeSH ... The sequences obtained from the isolated spots revealed that they have close similarity to creatine kinase B (CKB) isoforms, ... Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group ... Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group ...
... creatine liberates a molar excess of mitochondrial ADP-pu … ... Creatine Kinase, BB Form / genetics Actions. * Search in PubMed ... 1:. Creatine kinase activity in BAT is dependent on CKB. a, Schematic of creatine methyl-D3 (D3-creatine) supplementation of ... h, Cartoon of creatine kinase activity from BAT lysates (h, left). Creatine kinase activity (PCr synthesis) from BAT extracts ... Creatine kinase B controls futile creatine cycling in thermogenic fat Janane F Rahbani 1 2 , Anna Roesler 1 2 , Mohammed F ...
A form of creatine kinase found in the BRAIN.. Entry Term(s). BB Creatine Kinase Brain Creatine Kinase Registry Number. EC 2.7. ... A form of creatine kinase found in the BRAIN.. Terms. Creatine Kinase, BB Form Preferred Term Term UI T009901. Date01/08/1981. ... Creatine Kinase [D08.811.913.696.640.150] * Creatine Kinase, BB Form [D08.811.913.696.640.150.500] ... 2006; CREATINE KINASE, BB FORM was indexed under CREATINE KINASE 2000-2005. History Note. 2006(2000). Date Established. 2006/01 ...
... of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase ... Elevated serum creatine kinase MB and creatine kinase BB-isoenzyme fractions after ultra-marathon running.. Noakes TD; ... Serum creatine kinase BB linked to immunoglobulin G.. Bohner J; Stein W; Kuhlmann E; Eggstein M. Clin Chim Acta; 1979 Sep; 97(1 ... 4. Macro creatine kinase BB isoenzyme in serum: most likely an antigen-autoantibody complex.. Urdal P. Scand J Clin Lab Invest ...
A form of creatine kinase found in the BRAIN.. Entry Term(s). BB Creatine Kinase Brain Creatine Kinase Registry Number. EC 2.7. ... A form of creatine kinase found in the BRAIN.. Terms. Creatine Kinase, BB Form Preferred Term Term UI T009901. Date01/08/1981. ... Creatine Kinase [D08.811.913.696.640.150] * Creatine Kinase, BB Form [D08.811.913.696.640.150.500] ... 2006; CREATINE KINASE, BB FORM was indexed under CREATINE KINASE 2000-2005. History Note. 2006(2000). Date Established. 2006/01 ...
BB Form Entry term(s). BB Creatine Kinase Brain Creatine Kinase Creatine Kinase, BB Creatine Kinase, Brain Kinase, BB Creatine ... BB Creatine Kinase. Brain Creatine Kinase. Creatine Kinase, BB. Creatine Kinase, Brain. Kinase, BB Creatine. Kinase, Brain ... 2006; CREATINE KINASE, BB FORM was indexed under CREATINE KINASE 2000-2005. ... A form of creatine kinase found in the BRAIN. Preferred term. Creatine Kinase, ...
BB Form N0000168297 Creatine Kinase, MB Form N0000168299 Creatine Kinase, Mitochondrial Form N0000168300 Creatine Kinase, MM ... MAP Kinase Kinase 6 N0000170606 MAP Kinase Kinase 7 N0000170480 MAP Kinase Kinase Kinase 1 N0000170477 MAP Kinase Kinase Kinase ... MAP Kinase Kinase Kinase 3 N0000170479 MAP Kinase Kinase Kinase 4 N0000170481 MAP Kinase Kinase Kinase 5 N0000170472 MAP Kinase ... N0000170603 MAP Kinase Kinase 1 N0000170602 MAP Kinase Kinase 2 N0000170601 MAP Kinase Kinase 3 N0000170607 MAP Kinase Kinase 4 ...
Creatine Kinase (CPK) - is an enzyme found in the brain, heart, skeletal muscle, and other tissues. Enzymes such as creatine ... There are three different forms of CK in your body, referred to as isoenzymes: CK-MB (found mostly in your heart); CK-MM ( ... located in your skeletal muscles and heart); CK-BB (found mostly in your brain). The small amount of CK in the blood comes ... kinase are proteins that help cells to perform their normal functions. Most of this energy in heart and muscle cells is used ...
Creatine Kinase, BB Form UI - D052276 MN - D8.811.913.696.640.150.500 MS - A form of creatine kinase found in the BRAIN. HN - ... A form of creatine kinase found in the MITOCHONDRIA. HN - 2006(2000) BX - Creatine Kinase, Mitochondrial MH - Creatine Kinase, ... Creatine Kinase, MB Form UI - D052279 MN - D8.811.913.696.640.150.625 MS - An isoenzyme of creatine kinase found in the CARDIAC ... HN - 2006(2000) MH - Creatine Kinase, Mitochondrial Form UI - D052281 MN - D8.811.913.696.640.150.750 MS - ...
... on the folding and aggregation of brain creatine kinase (CK-BB). We developed a method to purify CK-BB from rabbit brain and ... nonspecifically may protect CK-BB and allow it to exist in the active form. ... Effect of SNPs on creatine kinase structure and function: identifying potential molecular mechanisms for possible creatine ... compared to those of the wild-type creatine kinase to explore the potential molecular mechanisms of possible creatine kinase ...
Check the creatine kinase level. * Always exclude hypoglycemia as a cause of altered mental status. ... Roberts CA, Quednow BB, Montgomery C, Parrott AC. MDMA and brain activity during neurocognitive performance: An overview of ... Evolution of the toxins muscarine and psilocybin in a family of mushroom-forming fungi. PLoS One. 2013. 8(5):e64646. [QxMD ...
... isoenzymes test measures the different forms of CPK in the blood. CPK is an enzyme found mainly in the heart, brain, and ... Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes; Heart attack - CPK; Crush - CPK ... CPK-1 (also called CPK-BB) is found mostly in the brain and lungs ... The creatine phosphokinase (CPK) isoenzymes test measures the ... different forms of CPK in the blood. CPK is an enzyme found mainly in the heart, brain, and skeletal muscle. ...
creatine kinase B-type; Creatine kinase B-type; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; creatine ... kinase, brain; B-CK; Creatine kinase B chain. Form/Appearance. Purified (Purified IgG - liquid) ... Phosphatidylinositol-3-kinases 2a], Recombinant Dog Creatine kinase B-type (CKB), Rabbit anti-human creatine kinase, Muscle ... CREATINE PHOSPHOKINASE Creatine phosphokinase, also known as creatine kinase (CK), is an enzyme expressed by various tissues ...
Creatine Kinase: Increases in creatine kinase of ,300% were recorded in about 1% of aliskiren monotherapy patients vs. 0.5% of ... 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Fetal/neonatal morbidity and mortality 5.2 Head ... Five cases of creatine kinase rises, three leading to discontinuation and one diagnosed as subclinical rhabdomyolysis, and ... 3 DOSAGE FORMS AND STRENGTHS 150 mg light pink biconvex round tablet, imprinted NVR/IL (Side 1/Side 2) ...
Kinase, Aspartyl use Aspartate Kinase Kinase, BB Creatine use Creatine Kinase, BB Form ... Kinase Kinase, Map use Mitogen-Activated Protein Kinase Kinases Kinase Kinases, MAP use Mitogen-Activated Protein Kinase ... Kinase, Microtubule-Associated Protein-2 use Mitogen-Activated Protein Kinase 3 Kinase, Mitochondrial Creatine use Creatine ... Kinase, MM Creatine use Creatine Kinase, MM Form Kinase, Muscle Creatine use Creatine Kinase, MM Form ...
For instance, the estimated incidence of one of the more frequent NBIA forms (Pantothenate Kinase-Associated Neurodegeneration ... creatine kinase, ceruloplasmin, lactate, TSH) can be collected, too. To assess progression of motor symptoms, two well- ... BB, FG, AK, and TK contributed substantially to the manuscript as well as providing critical comments to the content. All ... A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat Genet. (2001) 28:345-9. doi: 10.1038/ ...
The generalized estimating equation model also showed that the co-infection group had higher levels of serum creatine kinase (p ... Please use the form below to submit correspondence to the authors or contact them at the following address:. Wei Liu, State Key ... Platelet-derived growth factor-BB and RANTES (regulated on activation, normal T cell expressed and secreted) were decreased in ...
37 for discussion). Different forms of actin and creatine kinase with conserved 3 untranslated regions have been shown to be ... G*TC*GAGGCCCCA HB GACTAGAGTCTTGCAGCAACACAGAATGTAATATAAGGCARATGCATCTGGGACITGACCAAAGTITGTTCTGTTTTGTT BB shh veescennac cece sescc ... and creatine kinase mRNAs from different organisms also have been conserved during evolution (see ref. ... 3) are predicted to form an a-helix that is not present in a;-2. Conversely, amino acid residues 97-100 and 120-123 of ZKEvmwt ...
Creatine Kinase: Increases in creatine kinase of ,300% were recorded in about 1% of aliskiren monotherapy patients vs. 0.5% of ... 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS 5.1 Fetal/neonatal morbidity and mortality 5.2 Head ... Five cases of creatine kinase rises, three leading to discontinuation and one diagnosed as subclinical rhabdomyolysis, and ... 3 DOSAGE FORMS AND STRENGTHS 150 mg light pink biconvex round tablet, imprinted NVR/IL (Side 1/Side 2) ...
Creatine Kinase BB (CK-BB) MAb * Creatine Kinase MB (CK-MB) MAb - 2 clones ... Physical Form:. Lyophilized powder. Purity:. ≥98% by SDS-PAGE. * Amount: Required Choose Options. 50 ug. 100 ug. ...
Serum amylase, creatine kinase, or hepatic transaminases may be elevated in association with pancreatic, muscle, or hepatic ... Knoell KA, Patterson JW, Wilson BB. Sudden onset of disseminated porokeratosis of Mibelli in a renal transplant patient. J Am ... Other skin changes observed in both forms of SSc include hypopigmentation and hyperpigmentation, xerosis, alopecia, ...
... such as elevated levels of creatine kinase or serum lactate dehydrogenase, might be present later in the course of illness. ... Chloramphenicol is no longer available in the oral form in the United States, and the intravenous form is not readily available ... Dantas-Torres F, Chomel BB, Otranto D. Ticks and tick-borne diseases: a One Health perspective. Trends Parasitol 2012;28:437-46 ... Data in the case report form system is collected by CDC from local and state health departments most often using a standardized ...
... ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis. Our results showed that EE: (1 ... In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK ( ... Kahn BB, Alquier T, Carling D, Hardie DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern ... The resultant phosphocreatine acts as the cytosolic transport and storage form of energy and used to regenerate ATP from ...
Creatine Kinase Creatine Kinase, BB Form Creatine Kinase, MB Form Creatine Kinase, Mitochondrial Form Creatine Kinase, MM Form ... Casein Kinase I Casein Kinase Ialpha Casein Kinase Idelta Casein Kinase Iepsilon Casein Kinase II Casein Kinases Caseins ... Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 3 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinase ... Cyclin-Dependent Kinase 9 Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase ...
The internal solution contained the following (in mm): 135 KCl, 18 HEPES, 1 EGTA, 4.6 MgCl2, 4 ATP, 0.3 GTP, 15 creatine ... mutation in the gene encoding VGLUT3 exchanges the amino acid alanine 211 for a valine and segregates with an early-onset form ... phosphate, and 20 U/ml phosphocreatine kinase. EPSCs were evoked by 2 ms of depolarization at 0 mV, resulting in an unclamped ... Lowell BB, *Kreitzer AC, *Sabatini BL. (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission ...
Thus, PDGF-BB, but not IGF-I, evokes a strong and rapid activation of mitogen-activated protein (MAP) kinase kinase and MAP ... 35 +/- 4% of area at risk, P < 0.01). The cardioprotection was confirmed by significantly lower plasma creatine kinase ... MIP-1 alpha was higher in RA SF (mean, 29 +/- 8 ng/ml [SE]) compared with other forms of arthritis (2.8 +/- 1.7), or ... Inhibitors of protein kinases and calmodulin-dependent enzyme system did not prevent the PUFA-induced migration inhibition, ...
Misrouted Case Report Forms (CRFs) Outline in DataFax. Author(s): F Appiah, N Moodley, M Holdsworth, C Lassnoff, S Debrincat, J ... PAK1 kinase promotes activated T cell trafficking by regulating the expression of CD62L and CCR7. Author(s): AD Dios-Esponera, ... Author(s): HM Hall, SW Bartlinski, GK Ha, T Ahmed, S Xu, KJ Footer, BB Smith, JW Croghan, A Rosenthal, DB Parrish ... Diagnostic and prognostic utility of urinary creatine riboside for early stage non-small cell lung cancer. Author(s): Y Kanke, ...
One clinical study reported no change in isokinetic and isometric muscle performance, central activation, or creatine kinase ... Acetaldehyde can form adducts with DNA and proteins that can produce injury through activation of immune responses. During the ... Rosito GA, Fuchs FD, Duncan BB. Dose-dependent biphasic effect of ethanol on 24-h blood pressure in normotensive subjects. Am J ... In binge drinking episodes, the form of alcohol consumed most frequently is beer (67.1%), followed by liquor (21.9%) and wine ( ...
Isoenzyme Pattern of Creatine Kinase in Acute Organophosphorus Compound Poisoning.. (. 2011-07. ) Vijayakumar, P G; Samudram, P ... Grade 4 cases showed a mild increase in CK-BB and CK-MB fractions along with predominant CK-MM fraction. The increase of CK in ... to analyze the legal and cultural flaws which have influenced the rapid and silent rise of this novel and dangerous form of ... In this study, an attempt was made to study the isoenzyme pattern of serum creatine kinase (CK) in acute OP poisoning. Acute OP ...
  • 19. Serum creatine kinase BB linked to immunoglobulin G. (nih.gov)
  • 20. Elevated serum creatine kinase MB and creatine kinase BB-isoenzyme fractions after ultra-marathon running. (nih.gov)
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (medlineplus.gov)
  • CREATINE PHOSPHOKINASE Creatine phosphokinase, also known as creatine kinase (CK), is an enzyme expressed by various tissues and cell types. (creatinekinases.com)
  • 2. Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals. (nih.gov)
  • 5. Differentiation of creatine kinase MB and IgA-linked BB isoenzymes on electrophoresis. (nih.gov)
  • 10. Elevated serum CK-MB and CK-BB isoenzymes in a patient with small cell lung cancer: a case report. (nih.gov)
  • The sequences obtained from the isolated spots revealed that they have close similarity to creatine kinase B (CKB) isoforms, heterogeneous nuclear ribonucleoprotein F (hnRNP F) and high mobility group box 1 protein (HMGB1) isoforms. (nih.gov)
  • The various protein kinase inhibitors vary greatly in chemical structure and there is little evidence for cross sensitivity to the liver injury. (nih.gov)
  • In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK (ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis. (biomedcentral.com)
  • The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl cyclase and sequestration of the receptors away from the cell surface. (jci.org)
  • CK catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). (creatinekinases.com)
  • 14. Activity concentration and mass concentration (monoclonal antibody immunoenzymometric method) compared for creatine kinase MB isoenzyme in serum. (nih.gov)
  • 15. Mass concentration and activity concentration of creatine kinase isoenzyme MB compared in serum after acute myocardial infarction. (nih.gov)
  • A form of creatine kinase found in the BRAIN . (nih.gov)
  • Our advisers will certainly help you choose the best Bovine Phosphatidylinositol-3-kinases 2a ELISA Kit[Phosphatidylinositol-3-kinases 2a], Porcine Phosphatidylinositol-3-kinases 2a ELISA Kit[Phosphatidylinositol-3-kinases 2a], Recombinant Dog Creatine kinase B-type (CKB), Rabbit anti-human creatine kinase, Muscle polyclonal Antibody products nad else and advise you on the best solutions for you and your business. (creatinekinases.com)
  • Seven studies from 2002 to 2010 show a tendency for 2g of carnitine to improve post-workout recovery through indicators such as 1) reduction in muscle injury, 2) reduction in lactic acid accumulation, 3) grip after training and 4) creatine kinase levels in the blood. (fotopharmacy.com)
  • The microglial processes then fused to form an area of containment between healthy and injured tissues, suggesting that microglia may represent the first line of defense following TBI [ 11 ]. (biomedcentral.com)
  • The synthetic form of EPO has been shown to exert remarkable, tissue-protective effects on several tissues. (biomedcentral.com)
  • 3. Sensitive and specific radioimmunoassay for creatine kinase BB isoenzyme in serum, with use of an autoantibody. (nih.gov)
  • Sonidegib (soe" ni deg' ib) is an orally available, kinase inhibitor with specific activity against a key step (activation of smoothened: SMO) in the hedgehog signaling pathway. (nih.gov)
  • Glycogen is found in the form of granules in the cytosol in many cell types. (np-mrd.org)
  • Leftmost panels illustrate different levels of input consistency and input noise by means of the spatial map of the stability of input Creatine cells, defined as the average PV correlation of input cells for each position. (mdm2-inhibitors.com)
  • Sonidegib is a small molecule kinase inhibitor that blocks signaling in the hedgehog pathway and is used in the therapy of unresectable or metastatic basal cell carcinoma. (nih.gov)
  • Nor do we ask you to fill a cursed inkwell with orc's blood and demon saliva and then use it to complete reams of return forms written in ancient Cyrillic script. (legionathletics.com)
  • 17. Creatine kinase B-subunit activity in human sera: temporal aspects of its sensitivity after myocardial infarction. (nih.gov)
  • Awareness, diagnosis, and control of tickborne rickettsial diseases are most effectively addressed by considering the intersecting components of human, animal, and environmental health that collectively form the foundation of One Health ( 1 ), an approach that integrates expertise from multiple disciplines and facilitates understanding of these complex zoonoses. (cdc.gov)
  • The proposed model accounts for differences in how place and grid cells represent different environments and provides a new interpretation in which place and grid cells mutually interact to form a coupled code for space. (mdm2-inhibitors.com)
  • 4. Macro creatine kinase BB isoenzyme in serum: most likely an antigen-autoantibody complex. (nih.gov)
  • 7. IgA-CK-BB complex with CK-MB electrophoretic mobility can lead to erroneous diagnosis of acute myocardial infarction. (nih.gov)
  • P61959.1 MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY 1367453_at NP_446195 8.92 hsp90 co-chaperone Cdc37 Cdc37 Rattus norvegicus " Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. (nih.gov)
  • In addition, it transports the toxic compounds that form inside the mitochondria outside them, in order to prevent their accumulation. (fotopharmacy.com)
  • Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed. (oncotarget.com)
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (medlineplus.gov)
  • The elevated CK-BB in cerebrospinal fluid is a useful predictor of hypoxic brain injury after cardiac arrest. (medscape.com)
  • All heart transplant recipients are at risk for cardiac allograft vasculopathy, a form of coronary disease characterized by diffuse intimal proliferation of the coronary vasculature, a process that is to a large extent immune-mediated. (medscape.com)
  • To identify patients with periprocedural MI (PMI), several conflicting definitions of PMI have been proposed, relying either on cardiac troponin (cTn) or the MB isoenzyme of creatine kinase, with or without supporting evidence of ischaemia. (medscape.com)
  • In using kinase inhibitors for treatment of cancer, serum aminotransferase elevations above 5 times the upper limit of normal (if confirmed) or any elevations accompanied by jaundice or symptoms should lead to dose reduction or temporary cessation. (nih.gov)
  • The 2 subunits can form 3 isozymes: CK-MM, CK-MB, and CK-BB. (medscape.com)