Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Creatine Kinase, BB Form: A form of creatine kinase found in the BRAIN.Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Creatine: An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.Creatine Kinase, MM Form: An isoenzyme of creatine kinase found in the MUSCLE.Creatine Kinase, Mitochondrial Form: A form of creatine kinase found in the MITOCHONDRIA.Creatine Kinase, MB Form: An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Clinical Enzyme Tests: Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.Phosphocreatine: An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)MAP Kinase Signaling System: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.Rats, Inbred BB: A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).Protein Kinases: A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Arginine Kinase: An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.Muscles: Contractile tissue that produces movement in animals.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Calcium-Calmodulin-Dependent Protein Kinases: A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)4-1BB Ligand: A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.src-Family Kinases: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.L-Lactate Dehydrogenase: A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Dizziness: An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Wolves: Any of several large carnivorous mammals of the family CANIDAE that usually hunt in packs.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Electrophoresis, Cellulose Acetate: Electrophoresis in which cellulose acetate is the diffusion medium.Immobilized Proteins: Proteins that are chemically bound to a substrate material which renders their location fixed. The immobilization of proteins allows their use in chemical reactions without being diluted by solvent.Batch Cell Culture Techniques: Methods for cultivation of cells, usually on a large-scale, in a closed system for the purpose of producing cells or cellular products to harvest.Enzymes, Immobilized: Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with little or no loss of their catalytic activity. Since they can be reused continuously, immobilized enzymes have found wide application in the industrial, medical and research fields.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Bioreactors: Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.Social Support: Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.Troponin: One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Troponin C: One of the three polypeptide chains that make up the TROPONIN complex of skeletal muscle. It is a calcium-binding protein.Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Reagent Strips: Narrow pieces of material impregnated or covered with a substance used to produce a chemical reaction. The strips are used in detecting, measuring, producing, etc., other substances. (From Dorland, 28th ed)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Influenzavirus A: A genus in the family ORTHOMYXOVIRIDAE causing influenza and other diseases in humans and animals. It contains many strains as well as antigenic subtypes of the integral membrane proteins hemagglutinin (HEMAGGLUTININS) and NEURAMINIDASE. The type species is INFLUENZA A VIRUS.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Scavenger Receptors, Class B: A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Myofibrils: The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Heart: The hollow, muscular organ that maintains the circulation of the blood.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.

Production of recombinant human creatine kinase (r-hCK) isozymes by tandem repeat expression of M and B genes and characterization of r-hCK-MB. (1/46)

BACKGROUND: Serum creatine kinase-MB isoenzyme (CK-MB) is widely used as a marker of myocardial injury. We prepared recombinant human CK (r-hCK) MB isoenzyme and examined its potential for use as a control material for assay of CK-MB in serum. METHODS: cDNAs encoding CK-M and CK-B subunits were inserted into the same plasmid vector, followed by transformation of Escherichia coli. The resulting three types of CK isoenzymes were purified by conventional chromatography. RESULTS: The ratio of MB to MM to BB was 50:40:10 on the basis of CK activity. Highly purified CK-MB with a specific activity of 533 U/mg was produced in a yield of 5.7 mg/g of packed cells. Purified r-hCK-MB had the isoelectric point (pI 5.3) and molecular size (46 kDa for the subunit) of native CK-MB. Its immunoreactivity in an ELISA using antibody against native heart enzyme was similar to that of cardiac CK-MB. The r-hCK-MB retained >90% activity for at least 4 months at 11 degrees C in a delipidated serum matrix in a liquid form at a concentration of 118 U/L. CONCLUSIONS: r-hCK-MB shows key properties of the native cardiac isoenzyme and may be useful as a control and calibrator for serum assays of CK-MB.  (+info)

Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia. (2/46)

To identify new markers of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (ALL), gene expression of leukemic cells obtained from 4 patients with newly diagnosed ALL was compared with that of normal CD19(+)CD10(+) B-cell progenitors obtained from 2 healthy donors. By cDNA array analysis, 334 of 4132 genes studied were expressed 1.5- to 5.8-fold higher in leukemic cells relative to both normal samples; 238 of these genes were also overexpressed in the leukemic cell line RS4;11. Nine genes were selected among the 274 overexpressed in at least 2 leukemic samples, and expression of the encoded proteins was measured by flow cytometry. Two proteins (caldesmon and myeloid nuclear differentiation antigen) were only weakly expressed in leukemic cells despite strong hybridization signals in the array. By contrast, 7 proteins (CD58, creatine kinase B, ninjurin1, Ref1, calpastatin, HDJ-2, and annexin VI) were expressed in B-lineage ALL cells at higher levels than in normal CD19(+)CD10(+) B-cell progenitors (P <.05 in all comparisons). CD58 was chosen for further analysis because of its abundant and prevalent overexpression. An anti-CD58 antibody identified residual leukemic cells (0.01% to 1.13%; median, 0.03%) in 9 of 104 bone marrow samples from children with ALL in clinical remission. MRD estimates by CD58 staining correlated well with those of polymerase chain reaction amplification of immunoglobulin genes. These results indicate that studies of gene expression with cDNA arrays can aid the discovery of leukemia markers. (Blood. 2001;97:2115-2120)  (+info)

Comparisons of the effects of tamoxifen, toremifene and raloxifene on enzyme induction and gene expression in the ovariectomised rat uterus. (3/46)

This study compares the actions of oestradiol, tamoxifen, toremifene and raloxifene on enzyme and gene expression in uterine tissues of ovariectomised rats over 72 h. The time-course for the induction of ornithine decarboxylase by the compounds showed a rapid biphasic response, while for creatine kinase brain type (BB) there was a continued increase over 72 h. The efficacy of induction showed that, with both markers, oestradiol gave the highest induction level, followed by tamoxifen or toremifene and then raloxifene. RT-PCR demonstrated that all compounds decreased oestrogen receptor (ER) alpha, ERbeta and ERbeta2 gene expression, 8-24 h after the first dose, suggesting that down-regulation of ER is not the primary cause of the difference in efficacy between these compounds. Using cDNA arrays, expression of 512 genes was examined in the uteri of oestradiol- or tamoxifen-treated rats. Both compounds resulted in the up-regulation of heat-shock protein 27, telomerase-associated protein 1 and secretin. However, most surprising was the marked down-regulation of Wilms' tumour and retinoblastoma genes. We speculate that this may result in a loss of regulation of the transition from the G1 to the S phase in the cell cycle and may make cells more vulnerable to the carcinogenic effects of tamoxifen in this tissue.  (+info)

Effect of weight bearing on recovery from nerve injury in skeletal muscle. (4/46)

We examined the effect of weight bearing (WB) on muscle recovery after nerve injury. Rats were housed in individual cages for 2 wk under WB or hindlimb suspension (HS) after being subjected to sciatic nerve compression for 1 wk. Sham operated on rats served as controls (sham group). We used 31P- and 19F-nuclear magnetic resonance spectroscopy combined with histochemical, physiological, and biochemical techniques to assess the outcome in the three groups. Creatine kinase-BB (CK-BB) mRNA levels expression, CK activity, and type I fiber density in the WB group were elevated compared with those in the HS group. In addition, sciatic functional index, tetanic tension, energy state, and local circulation dynamics of the WB group were greater than those of the HS group. These results suggested that WB plays an important role in muscle regeneration, inhibits the reduction of CK activity, and facilitates the activation of neural recovery, energy state, and local circulation dynamics.  (+info)

Expression of brain subtype creatine kinase in the zebrafish embryo. (5/46)

Creatine kinases (CK) play crucial roles in intracellular energy transfer. We have isolated a cDNA from zebrafish embryos, which encodes a CK highly related to the mammalian brain subtype creatine kinase (BCK). The bck mRNA is expressed maternally in the zebrafish embryo and transcripts are distributed uniformly in blastula and gastrula stages. Expression becomes restricted to the prechordal plate and the nervous system during subsequent somitogenesis stages. bck transcripts are abundant in primary neurons in the developing central nervous system of the 1-day-old embryo. While some bck expression persists in the hindbrain, expression vanishes in the spinal cord of the 2-day-old embryo. In summary, the expression pattern of bck is highly dynamic and suggests a role for bck during gastrulation and neuronal differentiation.  (+info)

Postoperative patterns and kinetics of cTnI, cTnT, CK-MB-activity and CK-activity after elective aortic valve replacement. (6/46)

OBJECTIVES: The aim of this prospective study was to evaluate postoperative kinetics of four different biochemical ischaemic markers after elective aortic valve replacement (AVR). Additionally, pre-, peri- and postoperative data were analysed in order to identify factors with possible impact on the postoperative release of the selected enzymes. DESIGN: Forty patients (14 males, 26 females, aged 70 +/- 11 years; EF = 54 +/- 18% [mean +/- SD]) undergoing elective AVR were prospectively included in this study. For all patients, serum concentrations of cTnI, cTnT, and serum activities of CK-MB and CK were measured preoperatively as well as 0, 6, 12, 24, 48 and 120 hours after removal of the aortic cross-clamp. Clinical data were assessed in all patients and correlated with postoperative enzyme patterns. RESULTS: There were no major complications. Preoperatively, all patients showed enzyme values in the normal range whereas the four ischaemic markers reached higher values postoperatively. cTnI reached its maximum values 24 hours (XMed = 2.35 micrograms/L, 95%-CI [2.0, 3.3]) and cTnT 48 hours after the operation (XMed = 0.239 microgram/L, 95%-CI [0.174, 0.283]). Typical biphasic release kinetics could be demonstrated for cTnT. There was a high linear correlation between cTnI and cTnT at all sampling times. In contrast, a high linear correlation between cTnI, cTnT, and CK-MB-activity was only found 48 hours after aortic unclamping. cTnI nearly was in normal range 120 h postoperatively (XMed = 0.5 microgram/L, 95%-CI [0.2, 0.6]), whereas cTnT still remained pathologically elevated (XMed = 0.223 microgram/L, 95%-CI [0.137, 0.299]). No linear correlation was found between maximum values of the ischaemic markers postoperatively and age, gender, body surface area, ejection fraction, LV-hypertrophy, operating time, ECC time, time of cardiac arrest, lowest body temperature, perfusion pressure, cardioplegia volume, reperfusion time, postoperative septiformic circulatory instability, or ventilation time. CONCLUSIONS: All four ischaemic markers showed individual peak characteristics and kinetics after uncomplicated AVR. In contrast to previous findings, aortic cross-clamping time had no detectable impact on postoperative peak patterns of any ischaemic marker.  (+info)

Two specific markers for neural differentiation of embryonal carcinoma cells. (7/46)

Two multipotential embryonal carcinoma (EC) cell lines, 1003 and 1009, can be induced to form preferentially neural derivatives in vitro. Synthesis of specific proteins during neural differentiation was followed by two-dimensional gel electrophoresis. The comparison of protein patterns obtained with neural and non-neural derivatives of these EC cell lines indicates that two changes are specific for the neural pathway: (i) the appearance of a new beta-tubulin isoform and (ii) the accumulation of the brain isozyme of creatine phosphokinase already present in small amounts in EC stem cells. These changes were found to take place early in the course of differentiation and to occur even when neurite outgrowth was prevented.  (+info)

Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation. (8/46)

Transcription and accumulation of brain-type creatine kinase (CKB) mRNA and its protein was examined during postnatal development of rat brain cerebellum, the brain region containing highest CKB mRNA in the adult. CKB protein was extremely low at day 1, increased about 10-fold until week 4 and remained constant until week 10. This time course was paralleled by cerebellar CKB mRNA, which was also extremely low at day 1 and increased 5-fold during the first 3 weeks and then remained constant. High levels of CKB protein were also detected in cultured primary cerebellar granular neurons. Nuclear run-on assays directly showed that CKB mRNA accumulation during postnatal cerebellar development was due to increased transcription. When compared with cerebrum and whole brain, cerebellar CKB mRNA accumulation during postnatal development was temporally delayed. Analysis of myocyte enhancer factor (MEF)-2 and Sp1, factors known to initiate or sustain CKB transcription in tissues other than brain, revealed that MEF-2 in cerebellum was low at week 1 but increased 3.5-fold by week 7, while Sp1 remained unchanged. The increase in CKB protein during cerebellar postnatal development was coincident with that of the ubiquitous mitochondrial CK protein and mRNA, indicating that a functional phosphocreatine energy shuttle probably exists for efficient ATP regeneration in the cerebellum. This should be beneficial for the many energy-demanding requirements during cerebellar development, as indicated by the observed temporal co-expression of CKB with myelin basic protein, which is involved in axon myelination by oligodendrocytes.  (+info)

Phagocytosis requires locally coordinated cytoskeletal rearrangements driven by actin polymerization and myosin motor activity. How this actomyosin dynamics is dependent upon systems that provide access to ATP at phagosome microdomains has not been determined. We analyzed the role of brain-type creatine kinase (CK-B), an enzyme involved in high-energy phosphoryl transfer. We demonstrate that endogenous creatine kinase (CK-B), in macrophages is mobilized from the cytosolic pool and coaccumulates with F-actin at nascent phagosomes. Live cell imaging with XFP-tagged CK-B and β-actin revealed the transient and specific nature of this partitioning process. Overexpression of a catalytic dead CK-B or CK-specific cyclocreatine inhibition caused a significant reduction of actin accumulation in the phagocytic cup area, and reduced complement receptor-mediated, but not Fc-γR-mediated, ingestion capacity of macrophages. Finally, we found that inhibition of CK-B affected phagocytosis already at the stage ...
Rabbit recombinant monoclonal Creatine kinase B type antibody [EPR3926] validated for WB, IP, IHC, ICC, Flow Cyt and tested in Human, Mouse and Rat. Referenced…
ALDOC Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 364 amino acids (1-364 a.a.).
Because p97/CDC‐48 is involved in protein degradation [5], we reasoned that it might modulate ER‐stress‐induced ckb‐2p transcription by eliminating a transcriptional repressor. To address this hypothesis, we designed an RNAi suppressor screen to identify genes whose knockdown could restore tunicamycin ckb‐2p::gfp activation following ER stress in a cdc‐48.2(−/−) mutant background ([4]; Fig 1C). We performed the screen in liquid culture by feeding cdc‐48.2(−/−); ckb‐2p::gfp synchronized L1 larvae with double‐stranded RNA (dsRNA)‐expressing E. coli derived from the C. elegans ORFeome library that targets 11,698 open reading frames covering 62% of C. elegans genes [6]). We then exposed the worms to a concentration of tunicamycin (0.5 μg/ml for 16 h) leading to maximal ckb‐2p::gfp induction in WT worms grown in liquid culture and analyzed them by flow cytometry [7] to measure their length, number and fluorescence intensity. Each RNAi clone was tested in duplicate, and ...
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Anti-Sarcomeric Alpha Actinin antibody [EA-53] (ab9465) has been cited in 63 publications. References for Human, Mouse, Rat, Goat, Pig, Xl, Xp in Flow Cyt…
引用Abcams Anti-Sarcomeric Alpha Actinin抗体[EP2529Y] (ab68167)的参考文献列表。为您列举引用本产品的发表文章,并提供信息包括论文文献数据库中的检索编号以便您搜寻文章
Established in 1979 from the bone marrow aspirated from a 55-year-old white man with small cell lung carcinoma prior to treatment; corresponds to NCI-H209; described as expressing neuroendocrine biochemical markers, e.g. neuron-specific enolase, brain creatine kinase, L-DOPA decarboxylase and ...
The carrier status of the HMSN/ACC gene can be confirmed through genetic testing. If you have a family history of HMSN/ACC, you may wish to consult a genetic counselor to understand your chances of having a child affected with HMSN/ACC and discuss family planning alternatives.. A paediatrician and/or neurologist will conduct a clinical examination, as well as genetic testing to confirm diagnosis of HMSN/ACC. Additional testing may be recommended, such as a brain scan performed with highly precise radiography technology (cerebral tomography) or an analysis of the electrical activity in the arm and leg muscles (electromyogram).. Symptoms appear shortly after birth or during the first year of life and are characterized by a lack of muscle strength and a delay in the development of motor skills. HMSN/ACC results in a loss of mobility and developmental abnormalities in the spine, hands, and feet. In addition to the physical symptoms, HMSN/ACC also causes mild to moderate cognitive impairment.. Babies ...
Mouse Monoclonal Anti-Alpha Actinin 4 Antibody (4D10) [DyLight 488]. Validated: WB, ELISA, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat. 100% Guaranteed.
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Clearly my myosin LC2 and my alpha actinin genes count as two (or is it 4, because I have two copies of each), but do we have 2 more if we add in those of the mouse? And how about the chimpanzee, if we discover that (unlike the mouse) their genes/alleles are absolutely identical to mine? Do we have 2 more when we add in the alleles of the mayor of my town (which, unbeknowst to her have synonomous substitions that make the protein-encoding portion of her DNA, but not the protein itself, different from mine)? Or how about those of the guy next door, who has a neutral mutation in an intron region? Or my third cousin, who has a neutral AA substition in his proteins ...
UniProtKB IDs are not shown, 1) if protein (or gene) isotypes are not specified in the referred articles, 2) if their IDs are not found in the UniprotKB database or by us ...
tomografía axial computarizada (es); CAT (is); Imbasan tomografi berkomputer (ms); Компютърна томография (bg); Bilgisayarlı tomografi (tr); Počítačová tomografia (sk); компютерна томографія (uk); 엑스선 전산화 단층 촬영 (ko); Komputila tomografio (eo); počítačová tomografie (cs); Kompjuterizirana tomografija (bs); tomodensitométrie (fr); računalna tomografija (hr); CT (vi); datortomogrāfija (lv); компјутеризована томографија (sr); tomografia computadorizada (pt-br); x-ray computit tomografie (sco); Computertomographie (lb); komputertomografi (nn); computertomografi (nb); Kompyuter tomoqrafiyası (az); ಗಣಕೀಕೃತ ಛೇದಚಿತ್ರಣ (kn); سی تی سکەن (ckb); computed tomography (en); تصوير مقطعي محوسب (ar); Tomografiez jedet (br); 電腦斷層掃描 (yue); komputertomográfia (hu); Thien-nó Thôn-chhèn Só-mèu (hak); tomografia computada (ca); Computertomographie ...
dolor (es); Sársauki (is); sakit (ms); Болка (bg); durere (ro); Bolesť (sk); dolor (oc); Doloro (io); 고통 (ko); Ауырсыну (kk); doloro (eo); bolest (cs); bol (bs); ব্যথা (bn); douleur (fr); bol (hr); ווייטאג (yi); वेदना (mr); đau (vi); sāpes (lv); Skausmos (sgs); бол (sr); Kurwadziwa (sn); pyne (sco); smerte (nn); smerte (nb); Ağrı (az); ನೋವು (kn); ئازار (ckb); pain (en); ألم (ar); Poan (br); 痛 (yue); Fájdalom (hu); Min (eu); Dolor (ast); dolor (ca); Nanay (qu); poen (cy); боль (be); درد (fa); 疼痛 (zh); smerte (da); दुखाई (ne); 疼痛 (ja); боль (be-tarask); כאב (he); Dolor (la); 痛 (wuu); दर्द (hi); నొప్పి (te); kipuaisti (fi); Ցաւ (hyw); smärta (sv); ਪੀੜ (pa); வலி (ta); dolore (it); Dhimbja (sq); боль (ru); Doulè (ht); Valu (et); bol (sh); Ul-ol (war); Êş (ku); ağrı (tr); pian (ga); Dogghia (scn); dor (pt); ความเจ็บปวด (th); бол ...
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Actinin alpha (pan), 0.1 mg. The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins.
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BACKGROUND AND PURPOSE: Brain creatine (Cr) deficiencies (BCr-d) are rare disorders of creatine biosynthesis and transport. We performed consecutive measures of total Cr (tCr) and of its phosphorylated fraction, phosphocreatine (PCr), in the brains of children affected by Cr synthesis defects during a long period of therapy. The aim was to identify the optimal treatment strategy for these disorders. MATERIALS AND METHODS: Two patients with guanidinoacetate methyltransferase defect (GAMT-d) were treated with different amounts of Cr and with diet restrictions aimed at reducing endogenous guanidinoacetate (GAA) synthesis. Three patients with arginine:glycine amidinotransferase defect (AGAT-d) were treated with different Cr intakes. The patients treatments were monitored by means of (1)H- and (31)P-MR spectroscopy. RESULTS: Cr and PCr replenishment was lower in GAMT-d than in AGAT-d even when GAMT-d therapy was carried out with a very high Cr intake. Cr and especially PCr replenishment became more ...
Our results suggest that the clinical differences between mania and depression states are supported by contrasting levels of creatine kinase CK . The lack of correlations between creatine kinase level and motor items suggest that creatine kinase CK level in mania versus depression could emphasize the "thinking speed" and not the motor one ...
Background: Biomarkers specificity is an important factor for their reliable utilization. Known markers for acute myocardial infarction (AMI) including creati...
sp:CHKB_MOUSE] Chkb, Chetk, Chkl, Ck, Ck/Ek, Ck/Ek-beta, Ckb, Ckekb, Ek; choline kinase beta; K14156 choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82] ...
de Almeida Ribeiro E., Pinotsis N., Ghisleni A., Salmazo A., Konarev P. V., Kostan J., Sjöblom B., Schreiner C., Polyansky A., Gkougkoulia E. A., Holt M. R., Aachmann F. L., Žagrović B., Bordignon E., Pirker K. F., Svergun D. I., Gautel M., Djinović-Carugo K. (2014), The structure of human muscle α-actinin: Insight into the intramolecular regulation of ligand binding and Z-disk assembly, Cell 159(6):1447-60. ...
de Almeida Ribeiro E., Pinotsis N., Ghisleni A., Salmazo A., Konarev P. V., Kostan J., Sjöblom B., Schreiner C., Polyansky A., Gkougkoulia E. A., Holt M. R., Aachmann F. L., Žagrović B., Bordignon E., Pirker K. F., Svergun D. I., Gautel M., Djinović-Carugo K. (2014), The structure of human muscle α-actinin: Insight into the intramolecular regulation of ligand binding and Z-disk assembly, Cell 159(6):1447-60. ...
Hee Jeong Son, Yoon Hee Lee, Jeong Hoon Chae, Chang Keun Kim Biol Sport 2015; 32(4):357-361 It is commonly assumed that creatine kinase (CK) activity in plasma is related to a state of an inflammatory response in 24-48 h and ...
article{2910d34e-79d3-4a7a-880b-f6f182695042, abstract = {Objective . Intestinal ischaemia is a life-threatening condition with high mortality, and the lack of accurate and readily available diagnostic methods often results in delay in diagnosis and treatment. The aim of this study was to investigate the accuracy of different plasma biomarkers in diagnosing intestinal ischaemia. Material and methods . Prospective inclusion of patients older than 50 years with acute abdomen admitted to hospital in Karlskrona, Sweden, between 2001 and 2003. Venous blood was sampled prior to any surgery and within 24 h from onset of pain. D-lactate, alpha glutathione S-transferase, intestinal fatty acid binding protein, creatine kinase B, isoenzymes of lactate dehydrogenase (LD) and alkaline liver phosphatase (ALP) were analysed. D-dimer was analysed using four different commercially available test kits. Results . In-hospital mortalities among patients with (n = 10) and without (n = 61) intestinal ischaemia were 40 ...
McQuade and colleagues (1) suggest that achieving predischarge natriuretic peptide (NP) thresholds is associated with reduced heart failure mortality and readmissions. Although this proposed association has biological plausibility, it should be evaluated with caution. One suspects that clinicians would hesitate to discharge patients who seem clinically unstable even if their NP level had decreased. As a result, patients would tend to remain hospitalized longer if their discharge was contingent on achieving both the clinical appearance of stability and a decreasing NP level rather than solely the former. A longer hospital stay in turn would mean that an early relapse would translate into a complicated, prolonged hospitalization rather than a readmission or an early outpatient death. As such, knowing whether the proposed association between a decreasing NP level and better outpatient outcomes persists even after controlling for length of stay would be of interest ...
Hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC; Online Mendelian Inheritance in Man No. 218000) is a severe and progressive autosomal-recessive polyneuropathy associated with hypotonia, mental retardation, dysmorphism, variable degrees of agenesis of the CC, and visual/auditory hallucinations, resulting in death typically during the third decade (Dupré et al., 2003). Our group previously reported that the K+/Cl− cotransporter 3 (KCC3), encoded by the SLC12A6 gene, is disrupted in patients with this disorder (Howard et al., 2002). KCC3 belongs to a family of four K+/Cl− cotransporters that have crucial roles in ion homeostasis, cell volume regulation, and modulation of the cellular responses to GABA during neuronal development (Kahle et al., 2008). Structurally, KCC3 has 12 transmembrane domains and both the N and C termini extend into the cytoplasm (Hiki et al., 1999). The predominant mutation found in HMSN/ACC patients consists of a G ...
INTRODUCTION. Trauma of diverse origins is a common reason for presentation of pets for treatment. It is often difficult clinically to objectively quantify the severity of any trauma suffered by an animal. One approach is to measure changes in the various serum constituents that are known to alter in response to trauma or inflammation. Creatine kinase (CK) is an enzyme found predominantly in skeletal muscle and significantly elevated serum activity is largely associated with muscle damage. It is an extremely sensitive indicator of muscle damage, but is not specific as to cause14,27. Serum elevations in dogs are associated with cell membrane leakage and will therefore be seen in any condition associated with muscular inflammation, necrosis or degeneration. Peak serum activity is expected between 3 and 12 hours after muscular insult and the elevation is roughly proportional to the amount of muscle tissue involved1,5,27.It is also possible to quantify the mass of muscle damage if the changes in CK ...
Creatine kinase MT 1A Antibodies available through Novus Biologicals. Browse our Creatine kinase MT 1A Antibody catalog backed by our Guarantee+.
... definition, an enzyme that, during muscular activity, catalyzes the transfer of a phosphoryl group from phosphocreatine in muscle to produce ATP. See more.
Signs and symptoms that typically accompany an elevated creatine kinase include cardiac symptoms such as chest pain, breathing trouble, dizziness, excessive sweating and pain that reaches the jaw or...
University of Helsinki, Faculty of Biosciences, Department of Biological and Environmental Sciences, Division of genetics and Institute of Biotechnology. The actin cytoskeleton is essential for a large variety of cell biological processes. Actin exists in either a monomeric or a filamentous form, and it is very important for many cellular functions that the local balance between these two actin populations is properly regulated. A large number of proteins participate in the regulation of actin dynamics in the cell, and twinfilin, one of the proteins examined in this thesis, belongs to this category. The second level of regulation involves proteins that crosslink or bundle actin filaments, thereby providing the cell with a certain shape. α-Actinin, the second protein studied, mainly acts as an actin crosslinking protein. Both proteins are conserved in organisms ranging from yeast to mammals. In this thesis, the roles of twinfilin and α-actinin in development were examined using Drosophila ...
html, ,ul, ,li,,b,Summer Research: Production and purification of human ATP citrate Lyase protein for determining its function using structural analysis,/b,,/li, [,a href=http://www.bio.ucalgary.ca/contact/faculty/fraser.html, Dr. Marie Fraser ,/a,; May 2014 - Aug 2014] ,br, ,p,,b,Abstract: ,/b,ATP-citrate lyase (ACLY) is the enzyme that 1) links energy metabolism from carbohydrates to the production of acetyl-CoA in the cytoplasm of animals and 2) closes the reductive citric acid cycle in bacteria that use this cycle to fix carbon dioxide. The crystal structure of two-thirds of ACLY in complex with the substrate citrate, the inhibitor tartrate and the product ADP-Mg2+ has been already determined. These structures answered the question of where the organic acid bound to this member of the family of succinyl-CoA synthetase-related enzymes; but the truncated protein did not bind CoA. Our goal is to determine the structure of a longer form of ACLY, which will also show the binding sites of CoA ...
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CK is a dimeric enzyme. There are two common gene products, one coding for the subunit (so named because of its predominance in muscle) and the other for the B subunit (so named because of its predominance in brain tissue). The three common forms of active CK include two homodimers and one heterodimer. The first homodimer (CK-1) consists of two B subunits and is referred to as CKBB. The other has two M subunits and is referred to as CKMM (CK-3). The heterodimer has one of each subunit and is referred to as CKMB (CK-2)2. The specificity of CKMB for cardiac tissue is what has made it such a powerful diagnostic tool for the diagnosis of acute myocardial infarction (AMI). There is a third gene product which results in the mitochondrial form of CK.. Along with CKMB, significant levels of CKMM activity are found in cardiac muscle and therefore a large increase in total CK was once used as a tool in the diagnosis of AMI3. Once the CK isoenzymes were elucidated and isoenzyme tests became available, CKMB ...
Creatine Kinase is an enzyme present in muscle, brain, and other tissues of vertebrates that catalyzes the reversible conversion of ADP and phosphocreatine into ATP and c
Questions such as : What is the significance of a slightly elevated creatine kinase blood test presumed not cardiac related?. Find more questions on Blood Tests here.
Although it is by no means the only major risk factor, elevated serum (blood) cholesterol is clearly associated with a high risk of heart disease.. Most doctors suggest cholesterol levels should stay under 200 mg/dl. As levels fall below 200, the risk of heart disease continues to decline. Many doctors consider cholesterol levels of no more than 180 to be optimal. A low cholesterol level, however, is not a guarantee of good heart health, as some people with low levels do suffer heart attacks.. Medical laboratories now subdivide total cholesterol measurement into several components, including LDL ("bad") cholesterol, which is directly linked to heart disease, and HDL ("good") cholesterol, which is protective. The relative amount of HDL to LDL is more important than total cholesterol. For example, it is possible for someone with very high HDL to be at relatively low risk for heart disease even with total cholesterol above 200. Evaluation of changes in cholesterol requires consultation with a ...
Creatine phosphokinase (CK) isoenzymes are found in various tissues, such as skeletal muscle (CK-MM), cardiac muscle (CK-MB), and the brain (CK-BB). Elevated CK isoenzymes indicate damage or injury to specific tissue. Using CK isoenzymes as a marker in order to indicate muscle damage as a result of different degrees of resistance exercise has not been clearly examined. Purpose: To determine the changes in CK isoenzymes following resistance exercise at different intensities. Methods: Ten healthy recreationally resistance-trained (at least 3 - 6 days per week for a minimum of one year) men participated in the study. The participants performed a lower body resistance exercise, composed of leg press and unilateral knee extension, at two different intensities (low: 50% of 1-RM and high: 80% of 1-RM) in random order. The volume of two intensities was similar. Overnight fasting serum samples were collected at baseline and 3-hr, 24-hr, and 48-hr post exercise for each intensity to determine CK-MM, CK-MB, and CK
www.MOLUNA.de Cellular Bioenergetics: Role of Coupled Creatine Kinases [4194320] - Preface. I: Muscle Energy Metabolism. II: Substrate and Creatine Kinase Isoenzyme Compartmentation. III: Creatine Kinases and Metabolic Integration. IV: Molecular Biology of Creatine Kinases. V: Developmental and Pathological Alterations of Creatine Kinases. VI: Metabolic Regulation: Theoretical Basis.InhaltsverzeichnisPreface. I: Muscle Energy Metabolism. II: Substrate and Creatine Kinase Isoenzyme
Our study provided preliminary evidence that 4 weeks of supplementation with 3.0 g/day of guanidinoacetic acid is superior to creatine in facilitating cellular bioenergetics, as evaluated by the skeletal muscle and brain creatine levels," the researchers summarised.. But that doesnt mean that the researchers think athletes should start taking guanidinoacetic acid instead of their creatine supplements. The rise in homocysteine levels is too high for that in their view. It came perilously close to the 15 micromoles per litre that doctors regard as just still acceptable.. "Guanidinoacetic acid loading should be considered as a controversial dietary routine since elevated homocysteine has been implicated as a risk factor for cardiovascular disease, renal dysfunction, and orosteoporotic fractures. Therefore, long-term safety studies evaluating different biomarkers of cardiometabolic health during guanidinoacetic acid loading are warranted before recommending it as a novel dietary supplement.". Some ...
Effects of pH and KCl on the conformations of creatine kinase from rabbit muscle. Infrared, circular dichroic and fluorescence studies.: The activity loss of cr
Gentaur molecular products has all kinds of products like :search , Prospecbio \ Human Creatine Kinase MM \ CKI-273 for more molecular products just contact us
This test measures the amount of the enzyme creatine kinase in your blood. A certain form of this enzyme can help find out whether youre having a heart attack.
CK : Creatine kinase (CK) activity is greatest in striated muscle, heart tissue, and brain. The determination of CK activity is a proven tool in the investigation of skeletal muscle disease (muscular dystrophy) and is also useful in the diagnosis of myocardial infarction (MI) and cerebrovascular accidents. Increased levels of CK also can be found in viral myositis, polymyositis, and hypothyroidism.   Following injury to the myocardium, such as occurs in acute MI, CK is released from the damaged myocardial cells. A rise in the CK activity can be found 4 to 8 hours after an infarction. CK activity reaches a maximum after 12 to 24 hours and then falls back to the normal range after 3 to 4 days.
In the dog, creatine kinase (CK) is mostly present in the skeletal muscles, myocardium, brain and intestine. The MM isoenzyme predominates in muscles and myocardium. In plasma, reference values depend on the technique used and CK-MB accounts for about 30-45% of total CK activity. Sex has no influence on plasma CK activity, which is higher in young dogs than in adults. Plasma CK is elevated after physical exercise. After its release from the cells, CK reaches the plasma mostly via the lymphatic route and then remains in the plasma compartment. It is rapidly cleared with a half-life of about 2 hours. Muscle diseases are the main source of plasma CK elevations: inherited myopathies, malignant hyperthermia, hypothyroidism, vitamin E-selenium deficiency, prolonged decubitus, intramuscular injections, surgery, etc. Plasma CK is also increased in experimental myocardial infarction, for which the dog is an interesting model, allowing quantification of the damage by measuring the total CK activity ...
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The significance of elevated levels of the MB isomer of creatine kinase (CK-MB) when creatine kinase (CK) level is normal was studied in 400 patients with suspected acute myocardial infarction (AMI). In 350 patients both CK and CK-MB were elevated (group 1), in 21 only CK-MB was elevated (group 2), in 24 neither enzyme was elevated (group 3) and in 5 only CK was elevated (group 4). In 57% of patients in group 2 the CK level was doubled, with a characteristic enzyme curve, within the normal range, suggesting that an increase in CK had been missed because arbitrary definitions of normal were used. The median CK increase (60 IU/liter) in group 2 was greater than that in group 3 (23 IU/liter) (p | 0.001). Patients in group 1 with small AMIs had a relative increase in CK similar to that in group 2. However, patients in group 2 had a lower baseline CK level so that peak CK did not become abnormally high despite a 5-fold increase in some patients. In patients in group 1 with small AMIs, CK was elevated in
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Following acute myocardial infarction, CK-MB activity increases significantly and this elevation is highly specific for the laboratory diagnosis of myocardial infarction. Although total CK activity usually increases following myocardial infarction, in some patients only the CK-MB activity increases, while the total CK remains in the normal range. In this procedure CK activity is measured in the presence of an antibody to CK-M monomer. This antibody completely inhibits the activity of CK-MM and half of the activity of CK-MB, while not affecting the B subunit activity of CK-MB and CK-BB. Due to negligible concentrations of CK-BB in the circulation, the remaining activity, multiplied by a factor of 2, represents the activity of the CK-MB isoenzyme ...
CK (creatine kinase) is an enzyme (protein) found in several tissues, including muscles and the heart. Depending on the tissue, different forms of CK are present: CK-MM is primarily present in skeletal muscles, CK-MB represents 30% of CK from the heart, while CK-BB comes from the brain and smooth muscle, such as the intestinal walls. Atypical forms of CK (macro CK1 and macro CK2) can also be present. CK electrophoresis is most useful when muscular or cardiac disease does not seem to be responsible for the increased level of total CK.
Males. 6-11 years: 150-499 U/L. 12-17 years: 94-499 U/L. , or =18 years: 52-336 U/L. Females. 6-7 years: 134-391 U/L. 8-14 years: 91-391 U/L. 15-17 years: 53-269 U/L. , or =18 years: 38-176 U/L. Reference values have not been established for patients that are less than 6 years of age.. Note: Strenuous exercise or intramuscular injections may cause transient elevation of CK. ...
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1. The dose of pentobarbitone required for anaesthesia was significantly greater for dystrophic hamsters than for normal animals.. 2. Serum creatine kinase activity was significantly higher in dystrophic than in normal hamsters.. 3. Brain, heart and tibialis anterior muscle from dystrophic animals contained significantly less creatine kinase than the normal tissues.. 4. Creatine kinase in normal and dystrophic sera, as in skeletal muscles, consisted of MM isoenzyme. Heart creatine kinase consisted of both MM and MB types and brain contained only the BB isoenzyme.. 5. Pentobarbitone raised serum creatine kinase activity of normal and dystrophic hamsters to the same extent, elevation of enzyme activity being dependent on the amount of pentobarbitone injected.. 6. The sera of pentobarbitone-treated normal and dystrophic hamsters contained only the MM isoenzyme.. ...
It is commonly assumed that creatine kinase (CK) activity in plasma is related to a state of an inflammatory response in 24-48 h and also has shown
• The concentration of creatine kinase BB isoenzyme (CK BB) was measured by radioimmunoassay in CSF from 306 patients with various neurologic disorders. Levels
Walikonis, Randall S. and Oguni, Asako and Khorosheva, Eugenia M. et al. (2001) Densin-180 forms a ternary complex with the α-subunit of Ca^(2+)/calmodulin-dependent protein kinase II and α-actinin. Journal of Neuroscience, 21 (2). pp. 423-433. ISSN 0270-6474. PMCID PMC6763799. https://resolver.caltech.edu/CaltechAUTHORS:20120424-150007753 ...
The muscle protein, which covers the active sites on the actin filament at rest, is: a. Troponin-I b. Troponin-C c. Tropomyosin d. Myosin e. Actinin
... measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), brain (CK-BB) and skeletal ... The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which not all of the diagnostic criteria for AN are met, is ... Walder A, Baumann P (2008). "Increased creatinine kinase and rhabdomyolysis in anorexia nervosa". The International Journal of ... Blood urea nitrogen (BUN) test: urea nitrogen is the byproduct of protein metabolism first formed in the liver then removed ...
1999 [5]). Cytosolic BB-CK, as well as muscle-type MM-CK are both forming banana-shaped symmetric dimers, with one active site ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ... Thus creatine kinase is an important enzyme in such tissues.[3] Clinically, creatine kinase is assayed in blood tests as a ...
Creatine Kinase, BB Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKB genome location and ... Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein ... Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly ... phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in ...
It has been inferred that levels of CSF neuron-specific enolase, serum NSE, and creatine kinase (type BB) are indicative in the ... In human alpha enolase, the two subunits are antiparallel in orientation so that Glu20 of one subunit forms an ionic bond with ... pyruvate kinase, creatine kinase, and lactate dehydrogenase). The same study showed that the fastest rate of tumor growth ... When present in the same cell, different isozymes readily form heterodimers.[citation needed] Enolase is a member of the large ...
September 1997). "Assessment of coronary reperfusion after thrombolysis with a model combining myoglobin, creatine kinase-MB, ... AAK31795) is the soluble form of uPAR. uPAR is a membrane bound receptor for uPA, otherwise known as urokinase. suPAR results ... Lippi, G.; Mattiuzzi, C.; Comelli, I.; Cervellin, G. (2013). "Glycogen phosphorylase isoenzyme BB in the diagnosis of acute ...
Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column chromatography". ... This competition led to fast growth of new forms and the fast evolution of IC.[11] A challenge that needs to be overcome in the ... Firstly, CK- MM was eluted, then CK-MB, followed by CK-BB. Therefore, the isoenzymes found in each sample could be used to ... A buffered aqueous solution known as the mobile phase carries the sample from the loop onto a column that contains some form of ...
ISBN 0-444-88232-4. Mercer, Donald W (1974). "Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column ... This competition led to fast growth of new forms and the fast evolution of IC. A challenge that needs to be overcome in the ... Firstly, CK- MM was eluted, then CK-MB, followed by CK-BB. Therefore, the isoenzymes found in each sample could be used to ... Therefore, IC has been employed in drugs in the form of tablets and capsules in order to determine the amount of drug dissolve ...
... creatine kinase, bb form MeSH D08.811.913.696.640.150.625 --- creatine kinase, mb form MeSH D08.811.913.696.640.150.750 --- ... creatine kinase, mitochondrial form MeSH D08.811.913.696.640.150.875 --- creatine kinase, mm form MeSH D08.811.913.696.645 --- ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ...
Alquier T, Kawashima J, Tsuji Y, Kahn BB (2007). "Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in ... protein kinase A). AMPK is a heterotrimeric protein complex that is formed by α, β, and γ subunits. Each of these three ... AMPK is required for increased PGC-1α expression in skeletal muscle in response to creatine depletion. LKB1 knockout mice show ... liver kinase B1 (LKB1) which works in a complex with STRAD and MO25, calcium-/calmodulin-dependent kinase kinase 2 (]]CAMKK2, ...
Protein kinase B / Akt is thought to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. Akt itself is ... Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, ... Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable ... both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular stress. It is ...
Salvadori A, Fanari P, Ruga S, Brunani A, Longhini E (1992). "Creatine kinase and creatine kinase-MB isoenzyme during and after ... क्रियेटीन काइनेज़ टेस्ट (CK-टेस्ट): इसमें हृदय (CK-MB), मस्तिष्क (CK-BB) और मांसपेशियों (CK-MM) में पाए जाने वाले क्रियेटीन ... Lucka I, Cebella A (2004). "[Characteristics of the forming personality in children suffering from anorexia nervosa]". ... Walder A, Baumann P (2008). "Increased creatinine kinase and rhabdomyolysis in anorexia nervosa". The International Journal of ...
Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE (March 1999). "Actions of caffeine in the brain with special reference to ... Caffeine can produce a mild form of drug dependence - associated with withdrawal symptoms such as sleepiness, headache, and ... Tarnopolsky MA (2010). "Caffeine and creatine use in sport". Annals of Nutrition & Metabolism. 57 Suppl 2: 1-8. doi:10.1159/ ... As a competitive nonselective phosphodiesterase inhibitor, caffeine raises intracellular cAMP, activates protein kinase A, ...
doi:10.1146/annurev.bb.15.060186.000525. PMID 3013232.. *^ a b Gillen JB, Martin BJ, MacInnis MJ, Skelly LE, Tarnopolsky MA, ... This forms a tetrahedral intermediate and results in the ejection of −SCoA as the carbonyl reforms. The −SCoA is protonated to ... Adenylate kinase. *Creatine kinase. Inner membrane. oxidative phosphorylation. *Coenzyme Q - cytochrome c reductase ... Only when this citroyl-CoA has formed will another conformational change cause thioester hydrolysis and release coenzyme A. ...
Testing for the MB form of creatine kinase provides information about the heart's blood supply, but is used less frequently ... e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb ... Two endocardial tubes form here that fuse to form a primitive heart tube known as the tubular heart.[35] Between the third and ... In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary ...
Salvadori A, Fanari P, Ruga S, Brunani A, Longhini E (1992). "Creatine kinase and creatine kinase-MB isoenzyme during and after ... ಕ್ರಿಯಟಿನ್ ಕಿನೇಸ್ ಪರೀಕ್ಷೆ(CK-Test): ಕ್ರಿಯಟಿನ ಕಿನೇಸ್ ಎಂಬ ಒಂದು ಕಿಣ್ವವು ಹೃದಯದಲ್ಲಿ (CK-MB), ಮೆದುಳಿ (CK-BB) ನಲ್ಲಿ ಮತ್ತು ಅಸ್ಥಿಪಂಜರ ... Lucka I, Cebella A (2004). "[Characteristics of the forming personality in children suffering from anorexia nervosa]". ... Walder A, Baumann P (2008). "Increased creatinine kinase and rhabdomyolysis in anorexia nervosa". The International Journal of ...
1999 [5]). Cytosolic BB-CK, as well as muscle-type MM-CK are both forming banana-shaped symmetric dimers, with one active site ... Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed ... Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood ... Thus creatine kinase is an important enzyme in such tissues.[3] Clinically, creatine kinase is assayed in blood tests as a ...
Signs and symptoms that typically accompany an elevated creatine kinase include cardiac symptoms such as chest pain, breathing ... CK-MM is a form of creatine kinase found in the heart and skeletal muscles, whereas CK-MB is present in the heart. The type of ... creatine kinase located in the brain is called CK-BB.. A higher creatine kinase level usually manifests a few hours after a ... The heart, brain and skeletal muscles are the parts of the body that primarily contain the enzyme creatine kinase, states ...
... are based mostly on the functions of the enzyme creatine kinase (CK) and its high-energy product phosphocreatine (PCr). ... form homo-dimers or hetero-dimers, e.g. MM-CK in skeletal muscle, MM-, MB- and BB-CK in heart, or BB-CK in brain, kidney, ... Molecular structure and function of mitochondrial creatine kinases. In: Vial C (ed), Uversky VN (series ed) Creatine kinase- ... High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in ...
In addition to those, there are two mitochondrial creatine kinases, the ubiquitous and sarcomeric form. ... CK-BB occurs mainly in tissues, and its levels do rarely have any significance in bloodstream. Skeletal muscle expresses CK-MM ... Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2.7.3.2) expressed ... Thus Creatine Kinase is an important enzyme in such tissues. Clinically, creatine kinase is assayed in blood tests as a marker ...
... creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating ... With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, ... PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. ... PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. ...
... creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating ... Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form ... in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.By similarity. ... PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. ...
... measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), brain (CK-BB) and skeletal ... The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which not all of the diagnostic criteria for AN are met, is ... Walder A, Baumann P (2008). "Increased creatinine kinase and rhabdomyolysis in anorexia nervosa". The International Journal of ... Blood urea nitrogen (BUN) test: urea nitrogen is the byproduct of protein metabolism first formed in the liver then removed ...
CKBB creatine kinase B-type; creatine kinase, brain; CKBB; Brain creatine kinase; Creatine kinase B-type; Creatine Kinase BB ... Ester dyes are stable in solid form as long as they are protected from light and moisture. Esters are not stable in aqueous ... B-CK; BB-CK; creatine kinase-B; Creatine kinase B chain; ... Anti-Creatine Kinase-BB (CKBB/1268) Antibody # prefix. ... Creatine Kinase B Monoclonal Mouse Antibody (CKBB/1268) Creatine kinases (CK) are a large family of isoenzymes that regulate ...
Rabbit polyclonal Creatine kinase B type antibody validated for WB, ELISA and tested in Human and Mouse. Referenced in 5 ... looking for Ab specific to Creatine Kinase BB, MM and MB that does not crossreact with the other forms check homology human and ... Anti-Creatine kinase B type antibody. See all Creatine kinase B type primary antibodies. ... A KLH conjugated synthetic peptide selected within aa 200~300 of human Creatine Kinase BB. ...
Creatine Kinase, BB Form at the US National Library of Medicine Medical Subject Headings (MeSH) Human CKB genome location and ... Brain-type creatine kinase also known as CK-BB is a creatine kinase that in humans is encoded by the CKB gene. The protein ... Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly ... phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in ...
... that binds human creatine Kinase MB (also known as CKMB). ... Creatine Kinase MB antibody LS-C193283 is a protein G-purified ... there are two mitochondrial creatine kinase isoenzymes, the ubiquitous and sarcomeric form. (More About CKMB / Creatine Kinase ... CK-BB and CK-MB. The genes for these subunits are located on different chromosomes: B on 14q32 and M on 19q13. In addition to ... Most Popular CKMB / Creatine Kinase MB Antibodies. Anti-CKMB / Creatine Kinase MB Antibody LS-C14666 ...
Creatine kinase is a dimer occurring in various in three isoenzymic forms, depending on the particular combination of its non- ... identical subunits: BB (brain type); MM (skeletal type); and MB(hybrid type). Creatine kinase-MB isoenzyme is released into ... The sample continues to move to the control area and forms a pink to purple color, indicating the test is working and the ...
... creatine kinase (CK: three isozymes of CK-MM derived from skeletal muscle, CK-BB derived from smooth muscle, and CK-MB derived ... open ring-like configuration (C letter form).. FIG. 2. is a schematic diagram showing a form of the measuring probe in Example. ... The configuration may be a non-linear form or an open ring-form (C letter configuration) as shown in FIGS. 1D and 1E. . ... Binder resin containing polyhydroxyalkanoate, toner containing the binder resin, and image-forming method and image-forming ...
... evidenced by the leakage of creatine kinase-BB, was not seen, the jugular bulb venous hemoglobin saturation levels (,50% in 27 ... evidenced by the leakage of creatine kinase-BB, was not seen, the jugular bulb venous hemoglobin saturation levels (,50% in 27 ... evidenced by the leakage of creatine kinase-BB, was not seen, the jugular bulb venous hemoglobin saturation levels (,50% in 27 ... evidenced by the leakage of creatine kinase-BB, was not seen, the jugular bulb venous hemoglobin saturation levels (,50% in 27 ...
Creatine kinase is a dimer occurring in various in three isoenzymic forms, depending on the particular combination of its non- ... identical subunits:BB(brain type);MM(skeletal type); and MB(hybrid type). Creatine kinase-MB isoenzyme is released into ... The sample continues to move to the control area and forms a pink to purple color, indicating the 3 in 1 Cardiac Markers test ... acid residues on its N-terminal that are not exist on the skeletal forms thus making cTnI a specific marker for indicating ...
The recombinant BB-CK protein was purified to over 99% homogeneity from the total protein extract of AcDZ1-CKB infected cells ... formed up to 30% of the total soluble cellular protein. Upon analysis by PAGE, zymogram assay and gel filtration chromatography ... A full-length human creatine kinase B (B-CK) cDNA was used to produce a recombinant baculovirus (AcDZ1-BCK). Sf9 cells infected ... the recombinant protein behaved like authentic dimeric human BB-CK protein. Studies with a newly produced monoclonal antibody ( ...
... topographical interaction with the Na+-K+ ATPase and its modulators such as creatine kinase should modulate functions of Cl- ... In addition, activation of these kinases is modulated by humoral factors such as estrogen and taurine. Because these ... KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 ... BB (the predominant form in brain), MM (in skeletal muscle) and MB (in cardiac muscle). Of these, only CKB interacts with KCC2 ...
Rabbit recombinant monoclonal Creatine kinase B type antibody [EPR3926] validated for WB, IP, IHC, ICC, Flow Cyt and tested in ... ab108388, at 1/100 dilution, staining Creatine Kinase BB in Human heart by Immunohistochemistry, Paraffin-embedded tissue. ... Anti-Creatine kinase B type antibody [EPR3926] (HRP) (ab197066) *Anti-Creatine kinase B type antibody [EPR3926] (Biotin) ( ... Anti-Creatine kinase B type antibody [EPR3926]. See all Creatine kinase B type primary antibodies. ...
Creatine kinase Mb (CKMB) Clinical Use:. Background:. CK-MB is a dimeric enzyme. Three different iso-forms occur in normal ... circulation: CK-MM (muscle type), CK-BB (brain type) and CK-MB that is primarily associated with the myocardium. ... should match on the specimen and request form. This check may be performed prior to centrifugation by the Central Sort ...
BB Form Creatine Kinase * Chaperonins * Protein Disulfide-Isomerases * Electrophoresis * Mass spectrometry * Glial Fibrillary ... Together they form a unique fingerprint. * Sort by ...
CK-BB) Isoenzyme Recombinant. Full length Creatine Kinase BBisoenzyme with amino acid sequence identical to the native enzyme. ... Purified in theenzymatically active form ... creatine kinase B-type; creatine kinase-B; creatine kinase B ... Human Creatine Kinase BB Isoenzyme (DAG279) Human Creatine Kinase BB Isoenzyme, recombinant protein from P. pastoris Datasheet ... CreatineKinase BB (CK-BB) Isoenzyme Recombinant. Full length Creatine Kinase BBisoenzyme with amino acid sequence identical to ...
Chicken heart muscle contains almost exclusively the BB isoenzyme of creatine kinase (CK), its myofibrils, moreover, lack an M- ... Chicken heart myofibrils may thus possess binding sites for both M and B forms of CK. ... Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle. T Wallimann T Wallimann ... Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle. Isoenzyme-Specific Interaction of Muscle- ...
Creatine Kinase, BB Form - metabolism , Creatine Kinase, BB Form - genetics , Creatine Kinase, BB Form - chemistry , Proteomics ... Creatine Kinase, MM Form - chemistry , Creatine Kinase, BB Form - genetics , Creatine Kinase, BB Form - chemistry , Protein ... Creatine Kinase, BB Form - metabolism , Mice, Knockout , Bone Resorption - enzymology , Creatine Kinase, BB Form - genetics , ... Creatine Kinase, BB Form - biosynthesis , Creatine Kinase, BB Form - genetics , Neoplasm Metastasis - genetics , Animals , Mice ...
MM creatine kinase. Using a polyclonal antisera, we have localized BB creatine kinase to the cuboidal epithelial cells of the ... In human muscle creatine kinase (HMCK) this residue, Cys283, forms part of a conserved cysteine-proline-serine (CPS) motif and ... Several physical properties of creatine kinase (EC 2.7.3.2) isozymes MM (CK-MM, muscle-type) and BB (CK-BB, brain-type), both ... Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase.. Bürklen TS, Hirschy A and ...
Creatine Kinase consists of the M and B subunits and is found in the MM, MB and BB isomorphs. The CK-MB isomorph is found ... Form: Freeze-dried. Shelf life: 24 months @ 2-8 C. On-Board Stability: 14 days Sample: Non lipemic, non hemolyzed human serum. ...
  • Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats," Clinical and Experimental Pharmacology and Physiology , vol. 38, no. 1, pp. 55-62, 2011. (hindawi.com)
  • and (3) phosphorylation experiments, showing that the cellular energy sensor AMP-activated protein kinase (AMPK) is able to phosphorylate BCK at serine 6 to trigger BCK localization at the ER, in close vicinity of the highly energy-demanding Ca 2+ ATPase pump. (springer.com)
  • 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis. (wikipedia.org)
  • Protein kinase B / Akt is thought to downregulate PGC-1α, but upregulate its downstream effectors, NRF1 and NRF2. (wikipedia.org)
  • This antibody is specific for Creatine kinase BB. (abcam.com)
  • Almost all of the bound enzyme is located within the Z-line region of each sarcomere, as revealed by indirect fluorescent-antibody staining with antiserum against purified chicken BB-CK. (rupress.org)
  • Includes C-Reactive Protein (CRP), Rheumatoid Arthritis (RA) Factor, Antinuclear Antibody(ANA), Sedimentation Rate, Uric Acid plus Wellness #2 Essential Panel that includes Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP-14), Lipid Panel with Total Cholesterol: HDL Ratio, Thyroid Panel plus TSH plus Cyclic Citrullinated Peptide (CCP) Antibodies, Creatine Kinase (CPK), Aldolase and Prostate-specific Antigen. (walkinlab.com)
  • This antibody completely inhibits the activity of CK-MM and half of the activity of CK-MB, while not affecting the B subunit activity of CK-MB and CK-BB. (pointescientific.com)
  • The ELISA analytical biochemical technique of the MBS706326 kit is based on CK-BB antibody-CK-BB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CK-BB antigen targets in samples. (mybiosource.com)
  • Antibody specific for CK-BB has been pre-coated onto a microplate. (mybiosource.com)
  • Standards and samples are pipetted into the wells and any CK-BB present is bound by the immobilized antibody. (mybiosource.com)
  • After removing any unbound substances, a biotin-conjugated antibody specific for CK-BB is added to the wells. (mybiosource.com)
  • Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy , autoimmune myositides , and acute kidney injury . (wikipedia.org)
  • Clinically, creatine kinase is assayed in blood tests as a marker of myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy and in acute renal failure . (wikidoc.org)
  • The primary clinical use of CK studies is the diagnosis of Myocardial Infarction , (increased in the MB variant), but CK is also increased in different conditions as muscular diseases and traumas (MM and MB) and brain trauma and brain surgery (BB). (golifescience.com)
  • The determination of CK using creatine phosphate and adenosine-5'-diphosphate (ADP) as substrates rather than creatine and adenosine-5'-triphosphate (ATP) has several advantages in test performance as it allows for a faster reaction rate resulting in greater sensitivity. (randoxonlinestore.com)
  • BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. (wikipedia.org)
  • KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 and their downstream effectors STE20/SPS1-related proline/alanine-rich kinase (SPAK)-oxidative stress responsive kinase-1 (OSR1). (frontiersin.org)
  • BB improved diastolic function, partially restored metabolic enzymes and augmented contractility in PAH. (bris.ac.uk)
  • Protein and myosin content and pyruvate kinase (PK) activity were similar in normal and Duchenne muscular dystrophy cultures. (elsevier.com)
  • Creatine kinase (CK) activity was lower in Duchenne muscular dystrophy cultures and the isoenzyme distribution indicated MB-CK was significantly lower, while BB-CK was significantly higher in later Duchenne muscular dystrophy cultures. (elsevier.com)
  • The heart is an organ built of muscular fibres forming into a pyramidal shape. (dynamicdeism.org)
  • This article is about the screening of 528,410, mostly 4-6-week-old, boys in Germany between 1977 and 2011 for high levels of creatine kinase (CK) to identify those with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). (cdc.gov)
  • El uso indiscriminado de anabolizantes en los gimnasios ha aumentado de forma generalizada, entre éstos la hormona de crecimiento (HC) es una de las más utilizadas, y a corto plazo puede potencializar el crecimiento muscular, principalmente cuando es realizado en combinación con el entrenamiento de fuerza. (bvsalud.org)