Craniopharyngioma: A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Hypothalamic Neoplasms: Benign and malignant tumors of the HYPOTHALAMUS. Pilocytic astrocytomas and hamartomas are relatively frequent histologic types. Neoplasms of the hypothalamus frequently originate from adjacent structures, including the OPTIC CHIASM, optic nerve (see OPTIC NERVE NEOPLASMS), and pituitary gland (see PITUITARY NEOPLASMS). Relatively frequent clinical manifestations include visual loss, developmental delay, macrocephaly, and precocious puberty. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2051)Sella Turcica: A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.Hypopituitarism: Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.Pilomatrixoma: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)Eye Manifestations: Ocular disorders attendant upon non-ocular disease or injury.Diabetes Insipidus: A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.Cerebral Ventricle Neoplasms: Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.Central Nervous System Cysts: Congenital or acquired cysts of the brain, spinal cord, or meninges which may remain stable in size or undergo progressive enlargement.Third Ventricle: A narrow cleft inferior to the CORPUS CALLOSUM, within the DIENCEPHALON, between the paired thalami. Its floor is formed by the HYPOTHALAMUS, its anterior wall by the lamina terminalis, and its roof by EPENDYMA. It communicates with the FOURTH VENTRICLE by the CEREBRAL AQUEDUCT, and with the LATERAL VENTRICLES by the interventricular foramina.Odontogenic Cyst, Calcifying: A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)Neurosurgical Procedures: Surgery performed on the nervous system or its parts.Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Diabetes Insipidus, Neurogenic: A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.Myelinolysis, Central Pontine: A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)Jaw Neoplasms: Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Optic Chiasm: The X-shaped structure formed by the meeting of the two optic nerves. At the optic chiasm the fibers from the medial part of each retina cross to project to the other side of the brain while the lateral retinal fibers continue on the same side. As a result each half of the brain receives information about the contralateral visual field from both eyes.BostonHospitals, Pediatric: Special hospitals which provide care for ill children.Focal InfectionCysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Breast Cyst: A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Arachnoid Cysts: Intracranial or spinal cavities containing a cerebrospinal-like fluid, the wall of which is composed of arachnoidal cells. They are most often developmental or related to trauma. Intracranial arachnoid cysts usually occur adjacent to arachnoidal cistern and may present with HYDROCEPHALUS; HEADACHE; SEIZURES; and focal neurologic signs. (From Joynt, Clinical Neurology, 1994, Ch44, pp105-115)Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Cyst Fluid: Liquid material found in epithelial-lined closed cavities or sacs.TRPP Cation Channels: A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.Proto-Oncogene Proteins B-raf: A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Pituitary Irradiation: Radiation therapy used to treat the PITUITARY GLAND.Stereotaxic Techniques: Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.Hypernatremia: Excessive amount of sodium in the blood. (Dorland, 27th ed)Thirst: A drive stemming from a physiological need for WATER.Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Dehydration: The condition that results from excessive loss of water from a living organism.Information Centers: Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Rare Diseases: A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.National Health Planning Information Center (U.S.): A center in the HEALTH RESOURCES ADMINISTRATION Division of Planning Methods and Technology which provides access to current information on health planning and resources development.Poison Control Centers: Facilities which provide information concerning poisons and treatment of poisoning in emergencies.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.New JerseySpinal NeoplasmsVesicular stomatitis New Jersey virus: A species of VESICULOVIRUS causing VESICULAR STOMATITIS primarily in cattle, horses, and pigs. It can be transmitted to humans where it causes influenza-like symptoms.

Cyclic compression of the intracranial optic nerve: patterns of visual failure and recovery. (1/203)

A patient with a cystic craniopharyngioma below the right optic nerve had several recurrences requiring surgery. Finally the cyst was connected with a subcutaneous reservoir by means of a fine catheter. Symptoms of optic nerve compression recurred more than 50 times during the following year, and were relieved within seconds upon drainage of the reservoir. In each cycle, a drop in visual acuity preceded a measurable change in the visual field. The pattern of field changes was an increasingly severe, uniform depression. Optic nerve ischaemia induced by compression was probably the most important factor causing visual failure in this case.  (+info)

Recovery from anterograde and retrograde amnesia after percutaneous drainage of a cystic craniopharyngioma. (2/203)

A case is reported of a cystic craniopharyngioma involving the floor and walls of the third ventricle. Pronounced anterograde and retrograde amnesia were documented preoperatively by formal testing. Rapid improvement in both new learning capacity and remote memory occurred after percutaneous twist drill drainage of the cystic portion of the tumour. The relevance of these observations to the amnesic syndrome and its neuropathological basis is discussed.  (+info)

CT-guided stereotactic biopsy of deep brain lesions: report of 310 cases. (3/203)

OBJECTIVE: To evaluate the accuracy of CT-guided stereotactic biopsy in making correct pathological diagnosis and choosing corresponding management of brain tumors. METHODS: From 1991 to 1995, CT-guided stereotactic biopsy was performed in 310 patients with intracerebral lesions which were deep-seated or located in certain main functional areas. The patients were 198 men and 112 women. Their ages ranged from 4.5 to 70 years (average: 39.3 years). The lesions were located in the deep cerebrum (74 patients), the sellar area (62), the basal ganglion (51), the posterior part of the third ventricle (38), other intraventricleular area (21), the cerebellum (17) and the brain stem (9), and intracranial multiple lesions were found in 38 patients. RESULTS: Brain tumors were diagnosed pathologically in 266 patients (85.8%); inflammatory process in 25 (8.1%), other lesions in 8 (2.6%) and uncertain cases were 11 (3.6%). The overall positive rate of biopsy was 96.4% and the positive rate for brain tumor was 85.8%. Intracranial hematomas after biopsy were found in 5 patients (1.6%). There were no deaths induced by the biopsy or other serious complications. CONCLUSIONS: The results suggest that CT-guided stereotactic biopsy is a reliable method for histopathological diagnosis of brain tumors and it is also of great help in selecting appropriate management.  (+info)

Suprasellar arachnoid cyst presenting with precocious puberty : report of two cases. (4/203)

Suprasellar arachnoid cysts (SSAC) are uncommon intracranial lesions. Two patients of SSAC presenting with precocious puberty are described. In both the cases partial excision of the cyst wall, through a pterional craniotomy, establishing communication with the basal subarachnoid spaces was carried out. The endocrinological symptoms regressed after surgery. The clinical presentations of SSAC and the treatment options available are reviewed.  (+info)

Metastatic craniopharyngioma. (5/203)

We report a unique case of metastatic craniopharyngioma. Initially, the patient had a right frontal craniotomy for resection of a suprasellar mass, which was determined to be an adamantinomatous craniopharyngioma. Seven years later, an MR study of the brain showed two peripheral enhancing lesions adjacent to the dura and contralateral to the craniotomy site. Pathologic examination again showed adamantinomatous craniopharyngioma. Although recurrence, both local and along surgical tracts due to implantation of craniopharyngioma tissue, has been reported, this case raises the possibility of meningeal seeding to remote sites.  (+info)

Atypical Rathke's cleft cyst associated with ossification. (6/203)

We report a case of symptomatic Rathke's cleft cyst with ossification. CT scans showed curvilinear calcification on the wall of the cyst. MR images revealed a cystic sellar lesion with a nodular solid mass extending to the floor of the third ventricle. This case shows that calcification of the suprasellar cyst does not always suggest craniopharyngioma. Rathke's cysts should be histologically differentiated from craniopharyngiomas because their treatments are different.  (+info)

Long-term magnetic resonance imaging follow-up of asymptomatic sellar tumors. -- their natural history and surgical indications. (7/203)

Serial magnetic resonance (MR) images and clinical symptoms were analyzed in 23 patients with sellar lesions, who were followed up without initial therapy for mass reduction to evaluate their natural history and surgical indication for these lesions. The patients were aged 17 to 78 years (mean 47.3 years) and the follow-up period was 1.5 to 11.6 years (mean 5.1 years). Lesions were divided into two types based on the MR imaging findings, regardless of their histological types. Type C was cystic with or without enhancement of the smooth and thin wall. Type S had enhanced solid components. Ten patients had Type C tumors. Three patients presented with sudden onset of headache. The tumor size spontaneously decreased with intensity change, indicating pituitary apoplexy as the trigger of the onset and intensity change. Four patients presented with the visual disturbance which improved with the reduction of tumor size, but three patients deteriorated and required surgery. The operation revealed Rathke's cleft cyst. The remaining three patients were found incidentally and have been asymptomatic without MR imaging changes. Thirteen patients had Type S tumors. Six patients of nine with 14 mm or larger tumors developed symptomatic tumor enlargement over the follow-up period of 1.2 to 8.6 years (mean 4.9 years) and required treatment. The remainder showed no change. Type C tumors frequently shrink or even disappear spontaneously. We can justify conservative follow-up of Type C tumors in patients with no or only transient symptoms. Type S tumors, larger than 14 mm in size, need closer observation or treatment because they often enlarge and become symptomatic.  (+info)

Tension pneumocephalus after neurosurgery in the supine position. (8/203)

Tension pneumocephalus has been reported most frequently after posterior fossa surgery performed in the sitting position. We present a paediatric patient who developed tension pneumocephalus in the postoperative period after decompression of a craniopharyngioma performed with the patient in the supine position.  (+info)

Craniopharyngiomas are benign tumours that show a bimodal age distribution and arise in two distinct clinicopathological variants: the adamantinomatous and the papillary subtypes.1 The molecular mechanisms involved in craniopharyngiomas remain elusive. While a genetic susceptibility is not known, there are reports describing the occurrence of craniopharyngiomas in consanguineous siblings2 as well as in a mother and daughter.3 To date, cytogenetic (that is, karyotypic) data on only 11 craniopharyngiomas have been published,5-,8 and have shown multiple chromosomal abnormalities in two cases, both of which involved chromosomes 2 and 12,5,7 while the other nine cases presented with normal karyotypes6,8; four additional craniopharyngiomas showed no mutations of the TP53 tumour suppressor gene.9 In view of the association of naevoid basal cell carcinoma or Gorlin syndrome with the occurrence of craniopharyngiomas, a recent study was carried out on 22 adamantinomatous craniopharyngiomas. This found no ...
PRIMARY OBJECTIVES:. I. To determine the activity of BRAF and MEK inhibitor combination in untreated papillary craniopharyngiomas as measured by best response at any time during the first four cycles of BRAF and MEK inhibitor treatment.. II. To determine the activity of BRAF and MEK inhibitor combination in papillary craniopharyngiomas that have progressed after prior radiation treatment with or without surgical resection as measured by best response at any time during the first four cycles of BRAF and MEK inhibitor treatment.. SECONDARY OBJECTIVES:. I. To determine the progression-free survival of patients with papillary craniopharyngiomas receiving BRAF and MEK inhibitors.. II. To determine the toxicity of BRAF/MEK inhibitors in patients with papillary craniopharyngiomas.. III. To determine the activity of BRAF and MEK inhibitor combination in papillary craniopharyngiomas as measured by response of enhancing volume of craniopharyngioma.. IV. To determine the activity of BRAF and MEK inhibitor ...
Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alterations, and influenced by distinct molecular pathways and particular origins. The fact that CP is an uncommon tumor entity renders studies on large cohorts difficult and exceptional. In order to achieve further insights distinguishing CP variants, we conducted whole genome methylation (450 k array) and microarray-based gene expression studies in addition to CTNNB1 and BRAF mutation analysis using a comprehensive cohort of 80 adaCP and 35 papCP. BRAF V600E mutations were solely found in the papCP subgroup and were not detectable in adaCP samples. In contrast, CTNNB1 mutations were exclusively detected in adaCP. The methylome fingerprints assigned DNA
TY - JOUR. T1 - Proliferative activity in craniopharyngiomas. T2 - Clinicopathological correlations in adults and children. AU - Raghavan, Ravi. AU - Dickey, William T.. AU - Margraf, Linda R.. AU - White, Charles L.. AU - Coimbra, Caetano. AU - Hynan, Linda S.. AU - Rushing, Elisabeth J.. PY - 2000. Y1 - 2000. N2 - BACKGROUND: Craniopharyngiomas are slow-growing, locally invasive intracranial tumors that can generate considerable morbidity, and recurrences are often difficult to manage. Because reliable morphologic criteria for accurately predicting the clinical outcome of these tumors are lacking, we evaluated the growth potential of craniopharyngiomas by measuring their proliferative activity based on MIB-1 immunostaining for the Ki-67 antigen, which is expressed during all phases of the cell cycle except G0. METHODS: Paraffin sections from 37 cases of craniopharyngiomas were immunostained with the monoclonal antibody MIB-1, and a labeling index was derived in each case from an the with the ...
AbstractIntroduction: Craniopharyngioma of childhood are commonly cystic in nature. An intracystic catheter insertion and subsequent instillation of substances inducing cyst shrinkage seems a beneficial strategy avoiding additional morbidity in a highly vulnerable brain location. Methods: A systematic review of the medical literature was performed to identify potentially relevant, all languages articles using Ovid MEDLINE and EMBASE from inception to July 2011 and Cochrane Central Register of Controlled Trials to 3rd quarter 2011. All references were examined for relevancy. Results: Of 142 unique references x referred to substances used for intracystic craniopharyngioma treatment. General aspects of intracystic catheter insertion as well as response rates, risks and outcomes of children treated with intracystic radio-isotopes, bleomycin and interferon are critically reviewed and an outline for potential future endeavours provided. Conclusions: Interferon seems currently the intracystic substance with
Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis. The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, and CTNNB1 genes and evaluate a panel of miRNA expression in craniopharyngioma. We also verified whether the presence of CTNNB1 mutation is associated with clinical findings and miRNA expression. The study included 16 patients with adamantinomatous craniopharyngioma (nine children and seven adults; eight females and eight males; 6-55 years, median 15.5 years). DNA, RNA, and cDNA were obtained from craniopharyngioma and normal pituitaries. DNA was also extracted from peripheral blood of healthy subjects. All genes were amplified by polymerase chain reaction and direct sequenced. Relative quantification of miRNA expression was calculated using the 2(-ΔΔCt) method. We found no mutations in HESX1, PROP1, and POU1F1 genes and four polymorphisms in PROP1 gene ...
Craniopharyngiomas are benign epithelial tumors of the sellar region but can have significant neurological and endocrinological consequences and may require treatment that will cause further morbidity. The first description of a craniopharyngioma is credited to Zenker, who made this observation in 1857.
Craniopharyngiomas have always been an extremely challenging type of tumor to treat. The transsphenoidal route has been used for resection of these lesions since its introduction. The authors present a historical review of the literature from the introduction of the endonasal route for resection of craniopharyngiomas until the present. Abandoned early due to technological limitations, this approach has been expanded both in its application and in its anatomical boundaries with subsequent progressive improvements in outcomes. This expansion has coincided with advances in visualization devices, imaging guidance techniques, and anatomical understanding. The progression from the use of headlights, to microscopy, to endoscopy and fluoroscopy, and finally to modern intraoperative magnetic resonance-guided techniques, combined with collaboration between otolaryngologists and neurosurgeons, has provided the framework for the development of current techniques for the resection of sellar and suprasellar ...
Craniopharyngiomas (see the image below) are histologically benign neuroepithelial tumors of the CNS that are predominately observed in children aged 5-10 years.{file44804}These tumors arise from squamous cell embryologic rests found along the path of the primitive adenohypophysis and craniopharyngeal duct.
Surgery with cyst drainage. Surgery may be done to drain tumors that are mostly fluid-filled cysts. This lowers pressure in the brain and relieves symptoms. A catheter (thin tube) is inserted into the cyst and a small container is placed under the skin. The fluid drains into the container and is later removed. Sometimes, after the cyst is drained, a drug is put through the catheter into the cyst. This causes the inside wall of the cyst to scar and stops the cyst from making fluid or increases the amount of the time it takes for the fluid to build up again. Surgery to remove the tumor may be done after the cyst is drained.. Chemotherapy. Chemotherapy is a treatment that uses anticancer drugs to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach tumor cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly ...
Since a craniopharyngioma grows near the pituitary gland, symptoms are caused by the pressure the growing tumor puts on that glad as well as on nearby structures. The symptoms depend on what structure is being compressed:
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A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Craniopharyngioma
Charles H. Frazier (1870-1936), one of the pioneers of neurosurgery in the US, is known worldwide for devising surgical procedures to relieve trigeminal neuralgia and intractable pain. Less well-known are his substantial contributions to understanding and treating pituitary and parahypophyseal lesions. Along with Bernard Alpers, he defined Rathkes cleft tumors as a different pathological entity from adenomas and hypophyseal stalk tumors (craniopharyngiomas [CPs]). The surgical challenge posed by CPs piqued Fraziers interest in these lesions, although he never published a complete account of his CP series. An examination of the Charles Frazier papers at the College of Physicians of Philadelphia allowed the authors to identify 54 CPs that he had treated during his career. In the early 1910s, Frazier developed the subfrontal approach, which would become the primary surgical route to access these lesions, providing better control of the adjacent vital neurovascular structures than the ...
Purpose of this study is to investigate whether intraoperative imaging using a 1.5T MRI in craniopharyngioma surgery is useful in order to increase the
We identified 24 previously reported cases in addition to our three cases. Mean age was 36.6 years (range 5-68). There were 16 (59%) females. The most common (74%) presenting symptom was endocrinological deficits, typically either isolated diabetes insipidus (DI) or panhypopituitarism. Location was intrasellar in 3 (11%), suprasellar in 6 (22%), and intrasellar/suprasellar in 18 (67%) patients. Lesions were most commonly (83%) T1 hyperintense. Gross total resection was achieved in 16 (64%) and subtotal resection in 9 (36%) patients. Of the seventeen (63%) patients presenting with varying degrees of bitemporal hemianopsia, all had improvement in vision postoperatively. It is worth noting that no cases of preoperative hypopituitarism or DI improved postoperatively. Even though gross total resection was only achieved in 64%, there was only one recurrence reported. ...
Individuals with adult-onset craniopharyngioma reported postoperative quality of life measures that were comparable with those of other primary and secondary brain tumors, despite the benign biology of the condition, according to an analysis of German registry data published in The Journal of Clinical Endocrinology & Metabolism. “Adult craniopharyngioma, contrary to child-onset
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Bilateral subfrontal gives much better access than unilateral. The blind spot behind ipsilateral optic nerve can be visualised from the contralateral side. I never use unilateral approach. Head extended so that frontal lobes fall back by gravity. Do not use lumbar drain because much higher chance of extradural hematoma because frontal lobe often sunken at the end of surgery with drainage of CSF.. Bicoronal curvy incision results in better hair growth than straight one. Skin incision does not need to go all the way down to zygomatic arches unless pterygonal approach is needed as well. In that case head is tilted slightly toward that side. Harvest pericranium for repair using wet gauze to wipe the pericranium off the bone. Temporalis fascia may be harvested toward end of operation if needed for dural repair. Burr holes are made either above lateral orbital rim or behind depending on the amount of exposure needed. Use a long cutting blade to reach near midline and crack the middle.. Alternatively, ...
Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumor type, extent of resection and other clinical factors. Children who received radiation therapy on this study were evaluated for treatment failure at 12 months. In addition to the primary objective, the study was designed to explore the association between radiation dose and volume and a variety of neurological, endocrine and cognitive deficits up to 5 years after treatment ...
Story told by Jenny Shapiro- Mother of Alexis When Alexis was diagnosed with a brain tumor, I had never imagined what this would mean for our family long-term. The type of brain tumor she had is called Craniopharyngioma; which is a rare tumor found near the pituitary gland.. Although the surgery to remove the tumor a few years ago was a success; it in turn damaged Alexiss hypothalamus and pituitary gland, which are two organs that help regulate energy balance, appetite, and weight. My daughters adrenal insufficiency leaves her vulnerable to potentially lethal blackouts.. As we were leaving the hospital after her surgery, the doctor explained to us the extreme importance of carrying an emergency needle and vial of a special steroid called Solu- Cortef, which must be injected within minutes after feeling any symptoms. Without this hormone in her body; my daughter could easily become unresponsive very quickly, or even comatose.. This was profoundly frightening to me as a mother. I reached the ...
h2,How is a craniopharyngioma treated?,/h2,,h3,Surgery when the tumour is mostly solid,/h3,,p,One approach to treatment is to remove as much of the tumour as possible using surgery. This can be difficult because these tumours "stick" to nearby tissues. ,/p,,p,If only part of the tumour is removed in surgery, then radiation therapy may be used to treat the remaining tumour. Radiation involves the use of high-energy X-rays, gamma rays, or electrons to destroy tumour cells. ,/p,,p,Before the main operation to remove the tumour, the surgeon may need to do a smaller operation. If one of the cysts is pressing against an important part of the brain and causing an increase in pressure, the surgeon may decide to drain the fluid in the cyst. He will make a small hole (burr hole) in the skull and insert a tube into the cyst to drain it or he may put a permanent shunt in called an Ommaya reservoir. ,/p,,h3,Surgery when the tumour is mostly cystic,/h3,,p,If one of the cysts is pressing against an important ...
Shannon was diagnosed with a rare craniopharyngioma brain tumour when she was just nine-years-old. She underwent emergency surgery and has endured several operations over the years, plus treatment including radiotherapy and hormone replacement. Now 18, and a college student, she is certified blind and relies on a long cane to help her get about. She is looking forward to leaving home and studying at university.
Im the mom of Summer, who was diagnosed with a rare brain tumor called Craniopharyngioma on 4/29/2010 at 19 months old. She had two craniotomies before turning two, and started chemical therapy a few days after her 2nd birthday. Summer finished proton radiation in Boston at the end of February 2011, and now were in wait and see what happens mode! Here I blog about her treatment and progress as a way to keep family and friends up-to-date ...
Im the mom of Summer, who was diagnosed with a rare brain tumor called Craniopharyngioma on 4/29/2010 at 19 months old. She had two craniotomies before turning two, and started chemical therapy a few days after her 2nd birthday. Summer finished proton radiation in Boston at the end of February 2011, and now were in wait and see what happens mode! Here I blog about her treatment and progress as a way to keep family and friends up-to-date ...
Craniopharyngioma is a common tumor in childhood, but can also be seen in adults. These tumors often present with endocrine problems, abnormalities of appetite, visual problems. MRI gives diagnosis and treatment involves surgery. Attempt must be made at complete excision, with safeguarding of vital hypothalamic functions. Radiation may be required after surgery to halt tumor followed by surgical excision, with excellent results.. ...
Preoperative plain (a-f) and contrast (g-i)-computed tomography scan showing craniopharyngioma with calcification (arrow down) extending up to right side forame
Ashley Age 9 Craniopharyngioma Favorite character: Tigger and Pooh, because theyre funny Favorite Bert Show member: Bert, because hes funny! Favorite
At the European Molecular Biology Laboratory (EMBL) in Heidelberg, Professor Parton was mentored by Gareth Griffiths, where he honed his skills in electron microscopy while collaborating with other groups throughout the institute including Jean Gruenberg and Marino Zerial. He has maintained these collaborations to this day, despite the groups now being spread around the globe.. Collaboration has been central to his career. In a collaborative project with the laboratory of Kai Simons, he observed that the newly-discovered protein, VIP21 (later renamed caveolin-1), was an abundant marker protein of caveolae. Also at the EMBL Parton and Michael Way discovered a second member of the caveolin family, M-caveolin, now termed caveolin-3.. At The University of Queensland he collaborated with Professor John Hancock. Together they showed that caveolin mutants can act as dominant negative inhibitory mutants and that one of the mutants was a highly potent inhibitor of Ras signalling. Inhibition was specific ...
TY - JOUR. T1 - Stereotactic radiosurgery of residual or recurrent craniopharyngioma. T2 - New treatment concept using leksell gamma knife model C with automatic positioning system. AU - Yomo, Shoji. AU - Hayashi, Motohiro. AU - Chernov, Mikhail. AU - Tamura, Noriko. AU - Izawa, Masahiro. AU - Okada, Yoshikazu. AU - Hori, Tomokatsu. AU - Iseki, Hiroshi. PY - 2009/11/1. Y1 - 2009/11/1. N2 - Background/Aims: The present study analyzed the initial experience with the application of the original concept of robotic microradiosurgery using Leksell Gamma Knife Model C with automatic positioning system for management of craniopharyngiomas. Methods: Eighteen patients with residual or recurrent craniopharyngiomas underwent radiosurgery with the use of multiple isocenters, mainly of smaller size, which were positioned compactly within the border of the lesion with resultant improved dose homogeneity, increased average dose within the target, and sharp dose fall outside the treated volume. Treatment ...
Thirst is stimulated by increases in effective plasma osmolality that are detected by cerebral osmoreceptors located in the vascular organ of the lamina terminalis. However, surgical destruction or organic lesions of the lamina terminalis decrease the sensation of thirst in response to increased plasma osmolality. A 17-year-old boy who was diagnosed with craniopharyngioma at the age of 10 years and underwent tumor resection and gamma knife surgery was admitted for non-symptomatic severe hypernatremia. Although the sodium level was 173 mmol/L and serum osmolality was also high (371 mOsm/kg), the patient did not report increased thirst. Laboratory analysis revealed hypertonic dehydration and acute non-oliguric renal failure due to dehydration. Treatment was based on correction of hypernatremia with hydration and education about regular, periodic water ingestion. The patients hypernatremia and acute non-oliguric renal failure resolved with controlled daily fluid intake. To our knowledge, this is ...
This patient presented with hyperprolactinemia. MRI reveals T1/T2 hyperintense lesion in the left posterior aspect of the pituitary with convex superior margin with minimal enhancement on post contrast scans. The pituitary stalk is deviated to right. Fluid level is noted in the axial section. The optic chiasm & cavernous sinus appears normal. No parasellar abnormality. Differentials include first differential of rathkes cleft cyst versus other possibility of cystic adenoma. Rathkes cleft cysts are nonneoplastic, sellar or suprasellar epithelium-lined cysts arising from the embryologic remnants of Rathkes pouch in the pituitary gland. Hyperprolactinemia in Rathke cleft cyst is due infundibular stalk compression. ...
A Rathkes cleft cyst is a benign growth found on the pituitary gland in the brain, specifically a fluid-filled cyst in the posterior portion of the anterior pituitary gland. It occurs when the Rathkes pouch does not develop properly and ranges in size from 2 to 40mm in diameter. Asymptomatic cysts are commonly detected during autopsies in 2 to 26 percent of individuals who have died of unrelated causes. Females are twice as likely as males to develop a cyst. If a cyst adds pressure to the optic chiasm, it may cause visual disturbances, pituitary dysfunction, and headaches. The majority of pituitary patients with chronic headaches have Rathkes Cleft Cysts. This is believed to be caused by the constant change in volume and the drastic changes in vasopressure from fluctuations in gonadotrophs and ADH. The treatment of choice for symptomatic cysts is drainage and taking a biopsy. Radical excision is more dangerous because of the potential of damaging the patients pituitary function e.g. ADH ...
In embryogenesis, Rathkes pouch is an evagination at the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary (adenohypophysis), a part of the endocrine system. Rathkes pouch, and therefore the anterior pituitary, is derived from ectoderm. The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary. The anterior wall of Rathkes pouch proliferates, filling most of the pouch to form pars distalis and pars tuberalis. The posterior wall forms pars intermedia. In some organisms, the proliferating anterior wall does not fully occupy Rathkes pouch, leaving a remnant (Rathkes cleft) between the pars distalis and pars intermedia. Rathkes pouch may develop benign cysts. Craniopharyngioma is a neoplasm which can arise from the epithelium within the cleft. It is named for Martin Rathke. Rathkes cleft cyst synd/3564 at Who Named It? M. H. Rathke. Entwicklungsgeschichte der Natter (Coluber natrix). ...
Ophthalmologists are often the first port of consultation and patients may present with headache, unilateral or bilateral visual loss, visual field loss, hemislide phenomenon, post fixational blindness, see-saw nystagmus, cranial nerve palsy, papilledema, and bow tie optic atrophy. Besides causing the chiasmal syndrome most commonly, craniopharyngioma has infrequently been reported to cause junctional scotoma, paracentral bitemporal hemianopia(anterior or posterior optic chiasma syndrome) or homonymous hemianopia (optic tract syndrome). However because of the suprachiasmatic location of the tumour there is a clear association between inferior visual field defects and craniopharyngioma, but in clinical practice most patients do not present with inferior field loss (as in our patient) (4). Pleomorphism- distinct change from one type of field defect into another type of visual field defect- is characteristic of craniopharyngioma. It is related to intermittent emptying of cyst fluid into ventricular ...
J Neurosurg 124:627-638, 2016. Craniopharyngiomas and similar midline suprasellar tumors have traditionally been resected via transcranial approaches. More recently, expanded endoscopic endonasal transsphenoidal approaches have gained interest. Surgeons have advocated for both approaches, and at present there is no consensus whether one approach is superior to the other. The authors therefore compared surgical outcomes between craniotomy and endoscopic endonasal transsphenoidal surgery (EETS) for suprasellar tumors treated at their institution.. Methods: A retrospective review of patients undergoing resection of suprasellar lesions at Cedars-Sinai Medical Center between 2000 and 2013 was performed. Patients harboring suspected craniopharyngioma were selected for extensive review. Other pathologies or predominantly intrasellar masses were excluded. Cases were separated into 2 groups, based on the surgical approach taken. One group underwent EETS and the other cohort underwent craniotomy. Patient ...
J Neurosurg 124:627-638, 2016. Craniopharyngiomas and similar midline suprasellar tumors have traditionally been resected via transcranial approaches. More recently, expanded endoscopic endonasal transsphenoidal approaches have gained interest. Surgeons have advocated for both approaches, and at present there is no consensus whether one approach is superior to the other. The authors therefore compared surgical outcomes between craniotomy and endoscopic endonasal transsphenoidal surgery (EETS) for suprasellar tumors treated at their institution.. Methods: A retrospective review of patients undergoing resection of suprasellar lesions at Cedars-Sinai Medical Center between 2000 and 2013 was performed. Patients harboring suspected craniopharyngioma were selected for extensive review. Other pathologies or predominantly intrasellar masses were excluded. Cases were separated into 2 groups, based on the surgical approach taken. One group underwent EETS and the other cohort underwent craniotomy. Patient ...
Objective Rathkes cleft cysts (RCCs) are quite uncommon sellar lesions that can extend or even arise in the suprasellar area. The purpose of this study is to evaluate the effectiveness of both standard and extended endoscopic endonasal approaches in the management of different located RCCs. Methods We retrospectively analyzed a series of 29 patients (9 males, 20 females) complaining of a RCC, who underwent a standard or an extended endoscopic transsphenoidal approach at the Division of Neurosurgery, Department of Neurosciences and Reproductive and Odontostomatological Sciences, of the Università degli Studi di Napoli Federico II
Contributors. 1 Introduction (Edward J. Estlin, Richard J. Gilbertson and Robert F. Wynn).. Part I Central Nervous System Tumors of Childhood.. 2 Low- and High-Grade Glioma (Ian F. Pollack).. 3 Ependymoma (Thomas E. Merchant and Richard J. Gilbertson).. 4 Embryonal Tumors (Amar Gajjar and Steven C. Clifford).. 5 Pediatric Spinal Cord Tumors (Annie Huang, Ute Bartels and Eric Bouffet).. 6 Pediatric Craniopharyngioma, Mixed Glioneuronal Tumors, and Atypical Teratoid/Rhabdoid Tumor (Adrienne Weeks and Michael D. Taylor).. Part II Hematological Disorders.. 7 Acute Lymphoblastic Leukemia (Robert F. Wynn).. 8 Acute Myeloid Leukemia and Myelodysplastic Disorders (David K.H. Webb).. 9 Non-Hodgkins Lymphoma (Angelo Rosolen and Lara Mussolin).. 10 Hodgkins Lymphoma (Wolfgang Dörffel and Dieter Körholz).. 11 Histiocytic Disorders (Sheila Weitzman and R. Maarten Egeler).. Part III Solid Tumors of Childhood.. 12 Neuroblastoma (Sucheta J. Vaidya and Andrew D. J. Pearson).. 13 Renal Tumors (Edward J. ...
Objective: The presented single-centre study summarizes the outcome after intracavitary brachytherapy (IBT) using stereotactically applied phosphorus-32 (32P) colloid for the treatment of cystic craniopharyngiomas. We assessed its efficacy and safety, based on tumor control and endocrinological, ophthalmological, and neurological outcomes in one of the largest reported patient series.. Methods: Between April 1992 and January 2011, 53 patients (including 19 children aged , 20 y) with 56 cysts were treated with IBT-14 had no prior treatment and 39 had been treated for recurrent cysts. The intervention was performed by applying 200 Gy (median, range: 200-250 Gy) to the internal cyst wall (median volume 6.1 ml). The median clinical and radiological follow-up was 60.2 and 53.0 months, respectively.. Results: The actuarial tumor cyst control rate was 86.0 5.3% at 12, 24, and 60 months. The development of new cysts or progression of solid tumor parts (out-of-field progression) occurred in 18 patients ...
... Prolactinoma, Craniopharyngioma, Rathkes cleft cyst, Transnasal Transsphenoidal endoscopic pituitary surgery, technique of removal of tumour through the nose, Sellar and Parasellar tumors, Prof. Shahzad Shams presently works as Head and Professor of Neurosurgery Department at Lahore General Hospital, LGH, Lahore.
Cystic sellar lesions are a rare cause of hypopituitarism and extremely rare in the pediatric age group. The differential diagnosis is large and includes both primary pituitary abscesses and cystic components on pre-existing lesions, such as adenoma, craniopharyngioma, Rathkes cleft cyst, leukemia, granulomatous disease and lymphocytic hypophysitis. In the absence of a definitive diagnosis, treatment can be challenging. We report a case of a 15-year-old female, who presented with headaches, altered consciousness and diplopia after a molar extraction, for which she had received oral antibiotics. Broad-spectrum i.v. antibiotics were given for presumed meningitis. Blood cultures failed to identify pathogens. Cerebral magnetic resonance imaging showed a pituitary cystic lesion. Endocrine studies revealed abnormal pituitary function. In the absence of a therapeutic response, the patient underwent a transsphenoidal biopsy of the pituitary gland, which yielded a purulent liquid, but cultures were ...
Cystic sellar lesions are a rare cause of hypopituitarism and extremely rare in the pediatric age group. The differential diagnosis is large and includes both primary pituitary abscesses and cystic components on pre-existing lesions, such as adenoma, craniopharyngioma, Rathkes cleft cyst, leukemia, granulomatous disease and lymphocytic hypophysitis. In the absence of a definitive diagnosis, treatment can be challenging. We report a case of a 15-year-old female, who presented with headaches, altered consciousness and diplopia after a molar extraction, for which she had received oral antibiotics. Broad-spectrum i.v. antibiotics were given for presumed meningitis. Blood cultures failed to identify pathogens. Cerebral magnetic resonance imaging showed a pituitary cystic lesion. Endocrine studies revealed abnormal pituitary function. In the absence of a therapeutic response, the patient underwent a transsphenoidal biopsy of the pituitary gland, which yielded a purulent liquid, but cultures were ...
Appearances are unaltered. A cystic lesion mostly fills the pituitary fossa and bulges into the suprasellar cistern and not compressing or distorting the optic chiasm. It measures 17 x 10 by 11 mm, unaltered when compared to previous imaging, it continues to have a T1 hyper intensity and T2 hypointense (previous imaging) nodule posteroinferiorly within the cyst, which does not enhance. The remainder of the imaged brain (please note this study has been targeted to the pituitary, and as such the whole brain has not been imaged) appears unremarkable.. Conclusion:. Stable appearances when compared to previous imaging, and remain most consistent with a Rathkes cleft cyst. Particularly the luminal nodule, although unusually large, is quite characteristic. ...
In Females: HMG is used in a sequential manner in conjunction with HCG for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of anovulation is functional (secondary to pituitary insufficiency) and is not due to primary ovarian failure. HMG and HCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an in-vitro fertilization program. In Males: HMG is used in conjunction with HCG to stimulate spermatogenesis in primary hypogonadotropic hypogonadism (resulting from hypophysectomy, craniopharyngioma, cerebral aneurysm or chromophobe adenoma ...
Department of Otolaryngology and oral cancer can often cervical lymph node metastasis, the sites mostly in the deep cervical, middle and nerve chain lymph nodes. If there is transfer of supraclavicular lymph nodes, the first consideration should be from the chest, abdominal and pelvic malignancies. It should also pay attention to and craniopharyngioma, chordoma, and sphenoid sinus cyst phase identification. ...
Final Diagnosis: Suprasellar cyst, resection: consistent with Rathkes cleft cyst.Gross Description: The specimen is received in a single container labelled with the patients demographics and SUPRASELLAR CYST. It consists of multiple fragments o...
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The Virtua/GNI staff is trained and experienced in neurosurgical treatment of cancers of the central nervous system. Tumors of a variety of types with different growth rates may be located in the brain, spinal cord, nerves, skull or spine, and they may be noncancerous (benign) or cancerous (malignant). They may be a primary growth from the local tissues or a metastatic spread from a cancer in another part of the body. They are not among the most common types of cancers, and some primary forms are rare.. Types of primary brain tumors include gliomas, meningiomas, acoustic neuromas (schwannomas), pituitary adenomas, medulloblastomas, PNET (primitive neuroectodermal tumors), germ-cell tumor and craniopharyngiomas.. More common in the central nervous system are secondary tumors, which are other types of cancers that have spread from another location. The most common types of cancers to spread to the brain or other parts of the nervous system are cancers of the breast, colon and lung.. Imaging ...
TY - JOUR. T1 - Endoscopic versus open approaches to the skull base. T2 - A comprehensive literature review. AU - Raper, Daniel M S. AU - Komotar, Ricardo J. AU - Starke, Robert M.. AU - Anand, Vijay K.. AU - Schwartz, Theodore H.. PY - 2011/12/1. Y1 - 2011/12/1. N2 - The surgical approach to the skull base has traditionally been transcranial, often involving extensive bone drilling, brain retraction, and nerve manipulation to expose pathology. The endoscopic endonasal approach represents a minimal access, maximally aggressive alternative that provides a direct route to the area of interest. Few data exist that can be used to compare these 2 surgical strategies. We conducted a systematic review of case series and case reports in hope of furthering our understanding of the role of endoscopy in the management of difficult cranial base lesions. We found that the endonasal endoscopic technique generates equivalent or greater rates of gross total resection than open approaches for craniopharyngiomas, ...
Learn more about Panhypopituitarism at Doctors Hospital of Augusta DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Intracranial calcification may occur physiologically or pathologically and may be observed in asymptomatic individuals. Clinical assessment and laboratory investigations are required to determine whether these changes are physiological, idiopathic, neoplastic, inflammatory, traumatic, caused by metabolic disease, or manifestations of a generalised disease, such as hyperparathyroidism, vitamin D toxicity, Aicardi-Goutières syndrome, cerebroretinal microangiopathy with calcifications, COL4A1-related disease, Degos disease, Krabbe disease, Alexander disease, mitochondrial disease, tetrasomy 15, Hutchinson-Gilford progeria syndrome or chronic renal failure [1-3].. Certain intracranial tumours, especially oligodendrogliomas and craniopharyngiomas, tend to undergo calcification. Tumour calcifications were observed in approximately 83% of craniopharyngiomas [4] and 40% of intracranial oligodendrogliomas [5]. Approximately 22 to 62% of benign meningiomas were reported to contain calcification, while ...
... , BRAIN TUMORS OPERATED BY PROF. SHAHZAD SHAMS :- MENINGIOMAS , MALIGNANT Brain Tumour(Glioma, Astrocytoma, Metastatic), Cerebellopontine angle tumours, Acoustic Neuroma Schwannoma Tumor, Pituitary tumor, Prolactinoma, Colloid cysts, Craniopharyngioma, Rathkes Cleft Cyst, Sellar and Parasellar tumors and Brain Tuberculomas, Prof. Shahzad Shams presently works as Head and Professor of Neurosurgery Department at Lahore General Hospital, LGH, Lahore.
Neuroepithelial tumors. Astrocytic tumors. An increased risk of astrocytic tumors has been observed in patients who receive therapeutic radiation therapy for pituitary adenomas, craniopharyngioma, pineal parenchymal tumors, germinoma, and tinea capitis. In addition, children who receive prophylactic radiation therapy of the CNS for acute lymphoblastic leukemia have an increased risk of developing astrocytomas. Recurrent lesions often signal histologic progression to a higher grade; this malignant progression is associated with a cumulative acquisition of multiple genetic alterations. [4] Pilocytic astrocytoma (WHO grade I) is a grossly circumscribed, slow-growing, often cystic tumor that occurs primarily in children and young adults. [5] Histologically, pilocytic astrocytomas are composed of varying proportions of compacted bipolar cells with Rosenthal fibers and loose-textured multipolar cells with microcysts and granular bodies. This tumor is the most common glioma in children and represents ...
Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal that Sonic hedgehog (Shh) signaling is active in the cerebellar VZ and essential to radial glial cell proliferation and expansion of GABAergic interneurons. We demonstrate that the cerebellum is not the source of Shh that signals to the early VZ, and suggest a transventricular path for Shh ligand delivery. In agreement, we detected the presence of Shh protein in the circulating embryonic cerebrospinal fluid. This study identifies Shh as an essential proliferative signal for the cerebellar ventricular germinal zone, underscoring the potential contribution of VZ progenitors in the pathogenesis of cerebellar diseases associated with deregulated Shh signaling, and reveals a transventricular source of Shh in regulating neural development.. ...
Dr. Greenfield is a board-certified neurosurgeon who specializes in pediatric neurosurgery. In addition he sees certain adult patients with congenital neurosurgical conditions. Compassionate clinical care, research and education are all central to his philosophy as a neurosurgeon and physician.. As creator and director of the Chiari CARE program, Dr. Greenfield has developed an international reputation caring for children and adults with Chiari malformation, tethered cord, syringomyelia, and other associated conditions such as craniocervical instability, CSF leaks, and hydrocephalus as part of a large multidisciplinary team. Transitional neurosurgery - caring for patients with specific conditions from childhood through adulthood is a unique concept in medicine of which Dr. Greenfield is a strong proponent.. Dr. Greenfield also directs the pediatric skull base surgery program, evaluating and removing tumors of the pituitary gland region and skull base such as craniopharyngiomas with minimally ...
Rathke cleft cyst: Find the most comprehensive real-world symptom and treatment data on Rathke cleft cyst at PatientsLikeMe. 12 patients with Rathke cleft cyst experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Escitalopram to treat their Rathke cleft cyst and its symptoms.
Meningitis inflames the membranes that cover the brain and the spinal cord. It starts in a variety of ways. Various forms of meningitis come from bacteria...
The specialists at the Pituitary and Neuroendocrine Program at Weill Cornell Brain and Spine Center are highly skilled in the most advanced procedures for treating Rathke cleft cysts. Our relationship with NewYork-Presbyterian Hospital allows our doctors and surgeons access to the very best facilities and specialists, as well as the most leading-edge research laboratories, to ensure that you get the very best treatment available.
phdthesis{1a2f457d-a0f0-40b9-a3b2-daf2e925adf8, abstract = {Premature atherosclerosis, cardiovascular risk factors and increased cardiovascular mortality have been shown in patients with hypopituitarism on conventional hormone treatment, but without growth hormone (GH) replacement. The aims of paper I-III were to investigate separately the risks for cerebrovascular and cardiac mortality as well as the incidence of cardiovascular disease in patients with hypopituitarism and to assess the long-term prognosis for patients with craniopharyngioma. GH replacement has been associated with an impairment of glucose tolerance and the objectives of paper IV-V were to investigate whether individualized GH replacement therapy could avoid such a deterioration. There was a 1.75-fold increased cardiovascular mortality in 344 hypopituitary patients operated for a pituitary tumour compared to the general population. The risk for death in cerebrovascular disease was higher than for cardiac disease and females had ...
It is well known that circulating adiponectin concentrations are reduced in animal models of obesity and in patients with obesity or metabolic syndrome, despite adipocyte hypertrophy or increased body fat (2-6). However, the details of adiponectin production and release have varied among studies, especially in animal models (10,28,29,32,33). This is probably due to the apparently different etiology of the three types of obese animal models: genetic, diet-induced, and hypothalamic obesity (20,34).. VMH lesion-induced hypothalamic obesity in animals is the only obesity model that shows clear derangements of autonomic nervous activities (hyperactivity of the vagus nerve and hypoactivity of sympathetic nerves) compared with genetic (20), diet-induced obesity (34), and other types of hypothalamic obesity (19). Thus, there is a possibility that this animal model has different characteristics of adiponectin production and release, with resultant change of serum adiponectin, compared with those of other ...
Siobhans parents are advocates for not just their own daughter, but for other children with Panhypopituitarism. The word Panhypopituitarism. is daunting enough to read or say - but living with this complicated condition can be even harder. Siobhans dedicated parents, along with other parents, helped define a definition of the disease for a national organization for parents of children with growth related disorders. Simply put, panhypopituitarism means that s childs pituitary gland does not function properly and as a result, the child is deficient in hormones made by the pituitary. Some children have congenital panhypopituitarism, meaning they are born with it. Others have acquired panhypopituitarism following an event such as head trauma, brain tumor surgery, or brain radiation. Unfortunately the condition cannot be cured or reversed, but again, it can be effectively managed ...
Meeting with Dr.Lustig was very reassuring and very refreshing - although it did leave us with a ton of questions about which direction to go with Matts care. Dr.Lustig is *the* person researching hypothalamic obesity, and he reassured us that there is absolutely nothing we could do to stop the weight gain. We have had several people tell us that Matt just *HAS* to be sneaking and hoarding food, and that we needed to lock our cupboards. I have had a really hard time believing that because anyone who knows Matt knows that he is the most honest child on the planet. He has an almost debilitating conscience, is honest to a fault and he says hes not sneaking! Also, I do all the cooking and grocery shopping. I never notice food missing and I am with Matt for the majority of his meals. I spend 90% of my life in my kitchen and I have no evidence or suspicion that Matt is stealing food! Dr.Lustig discussed a study done in the 1970s in which 40 children were confined for one month. They were fed a ...
Looking for Rathke's cysts? Find out information about Rathke's cysts. craniobuccal pouch Explanation of Rathke's cysts
Non-Neoplastic Pathology of the Sellar Region: Common and Unusual Diseases. S Bravo-Grau1, L Arraño1, J Errázuriz1, J Cruz1, I Huete1 ...
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Background: Non functioning pituitary macro adenoma is rare during childhood. Therapeutic options are reduced to surgery and radiotherapy. Proton therapy is a particle therapy that uses a beam of protons to irradiate the tissue with the chief advantage that as a charged particle the dose is deposited over a narrow range and there is minimal exit dose.. Objective and hypotheses: Proton therapy is largely used in France for paediatric craniopharyngiomas irradiation and more recently for some adult pituitary adenomas. Proton therapy could be a good therapeutic option for benign tumor as pituitary adenoma in a young child to reduce side effects observed usually with conventional radiotherapy.. Method: We report a 10 years old boy with invasive and aggressive non-functioning pituitary adenoma treated by surgery and proton therapy with more 24 months follow up.. Clinical case: No significant familial or personal history. He was referred for a sudden lost of visual acuity and bilateral hemianopsia, but ...
Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are ,1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifesting as growth retardation.. First case: A 14-year-old boy was admitted because of growth retardation (S.D.S. height −2.5) and delayed puberty. Serum levels of SmC (21 ng/ml), cortisol (4.23 μg/dl), fT4 (0.61 ng/dl) and T3 (0.8 ng/ml) were low, TSH (1.84 μIU/ml) was normal and PRL (2556 μIU/ml) elevated. Stimulation tests of growth hormone (GH) secretion showed low GH (GHmax 1.6 ng/ml). Pituitary MRI revealed an intra- and suprasellar mass 1.2×3.8×2.3 cm with solid and cystic elements. Visual fields were normal. After the start ...
Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism. The specifics depend on the type of hormone. Some tumors secrete more than one hormone, the most common combination being GH and prolactin.. A pituitary adenoma may present with visual field defects, classically bitemporal hemianopsia. It arises from the compression of the optic nerve by the tumor. The specific area of the visual pathway at which compression by these tumours occurs is at the optic chiasma.. The anatomy of this structure causes pressure on it to produce a defect in the temporal visual field on both sides, a condition called bitemporal hemianopsia. If originating superior to the optic chiasm, more commonly in a craniopharyngioma of the pituitary stalk, the visual field defect will first appear as bitemporal inferior quadrantanopia, if originating inferior to the optic chiasm the visual field defect will first appear as bitemporal superior quadrantanopia. Lateral expansion of a pituitary adenoma ...
TY - JOUR. T1 - Indications and limitations of endoscopic endonasal surgery. AU - Yoshimoto, Koji. AU - Mukae, Nobutaka. AU - Kuga, Daisuke. AU - Iihara, Koji. PY - 2017/1/1. Y1 - 2017/1/1. N2 - The introduction of endoscopy, in conjunction with the technical development of endoscopy such as high definition and 3D, has had a significant impact on the field of endonasal transsphenoidal surgery. Cur-rently, endoscopic surgery is applied for the resection of not only sellar tumors but also parasellar tumors such as anterior skull base tumors, intraorbital tumors, cavernous sinus tumors, infratemporal fossa tumors, clival tumors, and others. Endoscopic endonasal surgery is expected to be used more frequently in the near future. In this paper, based on our own experiences and after reviewing the recent publications, we summarize the indications for endoscopic surgery, focusing on pituitary tumors, craniopharyngiomas, and tuberculum sellae meningiomas. In pituitary tumor surgery, operative results by ...
Expertise, Disease and Conditions: Achondroplasia, Arachnoid Cysts, Brachial Plexus Injuries, Brain Cancer, Brain Stem Tumors, Brain Tumors, Cerebral Palsy, Chiari Malformations, Craniopharyngiomas, Craniosynostosis, Endoscopy, Epilepsy Surgery, Hydrocephalus, Intramedullary Spinal Cord Tumors, Lipoma, Minimally Invasive Surgery, Neurosurgery, Oncology, Pediatric Brachial Plexus, Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Neurosurgery, Pediatric Spinal Cord Injury, Pediatric Spinal Cord Tumors, Pediatric Spinal Deformity, Pituitary Tumors, Skeletal Dysplasias, Spina Bifida, Spinal Cord Tumors, Spinal Dysraphism, Spine ...
Expertise, Disease and Conditions: Achondroplasia, Arachnoid Cysts, Brachial Plexus Injuries, Brain Cancer, Brain Stem Tumors, Brain Tumors, Cerebral Palsy, Chiari Malformations, Craniopharyngiomas, Craniosynostosis, Endoscopy, Epilepsy Surgery, Hydrocephalus, Intramedullary Spinal Cord Tumors, Lipoma, Minimally Invasive Surgery, Neurosurgery, Oncology, Pediatric Brachial Plexus, Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Neurosurgery, Pediatric Spinal Cord Injury, Pediatric Spinal Cord Tumors, Pediatric Spinal Deformity, Pituitary Tumors, Skeletal Dysplasias, Spina Bifida, Spinal Cord Tumors, Spinal Dysraphism, Spine ...
The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from adenoma to pituitary neuroendocrine tumour; (ii) reclassification of hormone-negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X-LAG and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathkes cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma ...
Injection of norepinephrine in the lateral ventricles of rats recovering from lateral hypothalamic anorexia caused immediate feeding and, frequently, overeating. Intraventricular administration of the α-noradrenergic blocker, phentolamine, suppressed feeding in both normal rats and rats that had recovered from lateral hypothalamic lesions. Feeding is reinforced by ascending medial forebrain bundle fibers that form α-noradrenergic synapses in the hypothalamus and forebrain. Damage to these fibers suppresses feeding by reducing noradrenergic transmission and, hence, the rewarding value of food. Recovery of feeding after hypothalamic lesions coincides with the recovery of noradrenergic reward function. ...
Intracranial tumours are often described as benign or malignant, but these terms cannot be directly compared with their extracranial counterparts:. A benign intracranial tumour may have devastating effects if allowed to expand within the rigid confines of the skull cavity. A benign astrocytoma may infiltrate widely throughout brain tissue preventing complete removal, or may occupy a functionally critical site preventing even partial removal.. A malignant intracranial tumour implies rapid growth, poor differentiation, increased cellularity, mitosis, necrosis and vascular proliferation, but metastases to extracranial sites rarely occur.. ...
Patient information literature is abundant in many ways, such as esophageal carcinoma or melanoma of the national institute of diabetes mellitus. 7 rigberg, d. A. B. C. Radiology and imaging workup the index procedure, a synovectomy, involves removal of the skin incision is made in the presence of a skin graft. Which could indicate active herpes around the intercostal vessels and prevertebral muscles, 7. Suggest smaller meals spaced throughout the brain and sellar region; ct can quickly result in permanent neurologic deficits. Nursing alert avoid placing vascular access device can be obtained with the index finger of one kidney only (unilateral) and are particularly difcult to determine when the child for initial assessment is required to evaluate extent of surgery, 48(8), 286330. 4. Insert indwelling catheter if closure device (vcd) angiography performed with a ph less than 92%). To promote maximum joint mobility, perform or teach the patient cope with the patient. 1. Can be used to manage ...
Responsive nerve stimulation (RNS) represents a safe and effective treatment option for patients with medically refractory temporal lobe epilepsy. In cases of long intraparenchymal course and posterior-anterior electrode direction through occipital burr holes, disciplined stereotaxy is essential for stimulation of the appropriate target. A 13-year-old female with a history of multifocal, independent, bitemporal-onset seizures since 12 months of age showing evidence of left-sided mesial temporal sclerosis on MRI, underwent placement of bilateral mesial temporal RNS leads. An O-arm spin was performed after the placement and the images obtained were fused to the preoperative CT images. It demonstrated curvature of the leads, with some deviation from the planned trajectory, but no deviation from the target, that was worse on the left side, compared to the right; the left lead was placed first, followed by the right lead. Following discussion with our epilepsy neurology colleagues in the operating ...
Sellar masses typically present in one or more ways:With neurologic symptoms, such as visual impairment or headacheAs an incidental finding on magnetic resonance imaging (MRI) performed for some other reasonWith hormonal abnormalitiesThis topic will
Were not ones to peruse the seedy underbelly of the adult film industry (hard to believe, with us working on the internet and all), but this story is too much...
TY - JOUR. T1 - Combined simultaneous endoscopic transsphenoidal and endoscopic transventricular resection of a giant pituitary macroadenoma. AU - Greenfield, J. P.. AU - Leng, L. Z.. AU - Chaudhry, Umar. AU - Brown, S.. AU - Anand, V. K.. AU - Souweidane, M. M.. AU - Schwartz, T. H.. PY - 2008/10/1. Y1 - 2008/10/1. N2 - Intrasellar and sellar-suprasellar adenomas are generally removed through a transsphenoidal approach. Giant adenomas with significant suprasellar extension often require a craniotomy or combined "above and below" approach. The use of endoscopes has increased the visualization capacity of the transsphenoidal route and made these surgeries less invasive. In this report, we describe a novel combination of the endoscopic transsphenoidal approach with the endoscopic transventricular approach to remove a giant pituitary macroadenoma extending into the third and lateral ventricles. The tumor was initially removed via an endoscopic transnasal transsphenoidal, transtuberculum, ...
A large avidly enhancing sellar/parasellar and suprasellar mass is evident. It measures 3.9 x 3.8 x 3.1 cm. The lesion invades the sphenoid bone, filling most of the right sphenoid sinus but also involving the left. It also invades into the base of the pterygoid. process on the right and into the adjacent apex of the petrous temporal bone. Posteriorly it invades through the right side of the clivus into the prepontine cistern. High T1 signal material within the remaining sphenoid sinus may represent proteinaceous or haemorrhagic fluid. The lesion is intimately related to the right ICA, from the posterior genu of the cavernous ICA, enveloping it in the cavernous sinus (and invading the cavernous sinus) and closely related to the supraclinoid ICA to just before the bifurcation. Enhancement is still noted within the internal carotid artery. In the suprasellar region it abuts and deforms the optic chiasm and adjacentoptic nerves. A further superior projection which is high T1 signal intrinsically ...
TY - JOUR. T1 - Metastases to Pituitary. T2 - A Case Report and Review of Literature. AU - Lee, Ji Hye. AU - Chotai, Silky. AU - Moon, Hong Joo. AU - Kim, Jong Hyun. AU - Park, Youn-Kwan. AU - Kwon, Taek-Hyun. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Pituitary metastasis (PM) secondary to systemic malignancies has been reported in the literature. Variety of clinical and neuroimaging presentation has been reported; however the diagnosis of PM is challenging. We report a case of a 44-year-old male with PM from non-small cell lung cancer (stage IV). He presented with sudden onset polyuria, polydypsia, and visual disturbance. Laboratory evaluation revealed pan-hypopituitarism and visual field test showed bitemporal lower quadrantanopsia. Brain magnetic resonance imaging demonstrated a suprasellar mass with focal hemorrhage and thickening of infundibular stalk. Surgical resection of the tumor followed by chemoradiotherapy was employed. Histopathologic examination of the tumor specimen revealed metastatic ...
According to recent investigations more than half of all growth disorders are due to growth hormone (GH) deficiency. I. The cause of the classic hypothalamo-pituitary dwarfism is: 1. perinatally acquired lesions of the hypothalamus; 2. suprasellar tumours; 3. brain malformations; 4. hereditary disturbances of GH-synthesis. - II. Constitutional delay of growth and adolescent development is clinically characterised by harmonious delay of growth, skeletal development and sexual maturation. The typical aspect of the pituitary dwarf is missing. Whereas provocation tests for GH do not show reliable deviations, assessment of the spontaneous GH secretion during sleep usually demonstrates a significant GH-deficit. - III. Impairments of GH synthesis with production of a hormone which reacts in the RIA but exhibits reduced biological effectivity causes the same clinical picture as constitutional delay. The disorders I--III can successfully be treated by GH. - IV. Familial short stature is based on the summation of
the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. If there is decreased secretion of most pituitary hormones, the term panhypopituitarism is used. The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of…
Care guide for Stereotactic Gamma Ray Surgery For Benign Intracranial Tumors (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Suprise, suprise, liberals lie yet again. link No matter what they say-Rathkes cleft cyst are considered a kind of a pituitary tumor by many brain surgeons and she was having increasing vision problems---and was told she needed to wait several months to see a neurosurgeon in Canada. I dont care what they say, thats unacceptable and no matter that what the dems are proposing-that it is different than the Canadian system it still will involve rationing and increasing wait times
3. Exercise 3 used ISSP date on the number of hours worked per week for a sample of 75 Japanese adults a. Calculate the mean for worked hours worked per week. b.Compare the value of the mean with those you have already.
Erdheim tumor: a synonym for craniopharyngioma. He used the term "nanosomia pituitaria" to describe pituitary dwarfism. Uber ...
Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". American Journal of Clinical Pathology. 120 (5): 732-6. doi ...
They are found in: Craniopharyngioma (Rathke pouch) Odontoma Ameloblastic fibroma Calcifying odontogenic cyst (Gorlin cyst) ... "The Spectrum of Malignancy in Craniopharyngioma". The American Journal of Surgical Pathology. 31 (7): 1020-8. doi:10.1097/PAS. ...
Scopis Surgical Navigation (23 November 2012). Scopis Augmented Reality: Path guidance to craniopharyngioma. YouTube. Retrieved ...
ISBN 0-7216-3256-4. Lustig, Robert H (November 2011). "Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and ...
ISBN 0-7216-3256-4. Lustig RH (2011). "Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment". ...
Brain tumors e.g. craniopharyngioma, prolactinoma, germinoma, glioma; diseases of hypothalamus, irradiation and trauma. ...
Craniopharyngioma is a neoplasm which can arise from the epithelium within the cleft. It is named for Martin Rathke. Rathke's ...
Craniopharyngioma is a neoplasm which can arise from the epithelium within the cleft. ...
... a 15-year-old female with well-documented hypopituitarism secondary to a craniopharyngioma; a 53-year-old female with carcinoma ...
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology 2009; 73:323-25. ...
Differentials to consider when diagnosing THS include craniopharyngioma, migraine and meningioma. Treatment of THS includes ...
Rohrer, TR; Fahlbusch, R; Buchfelder, M; Dörr, HG (2006). "Craniopharyngioma in a female adolescent presenting with symptoms of ...
... especially craniopharyngioma tumors. Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma. It is also ...
Pathological causes of weight gain may be Cushing's syndrome, hypothyroidism, insulinoma, craniopharyngioma. Genetic reasons ...
The embryonic remnants of Rathke's pouch may undergo neoplastic change called a craniopharyngioma. These tumors may develop at ...
... also occurs in long bones, and another variant is craniopharyngioma (Rathke's pouch tumour, pituitary ...
They may be mistaken for the much more common pituitary adenoma, as well as craniopharyngioma and meningioma. Symptoms from the ...
... to certain cases of papillary craniopharyngioma development. Other mutations which have been found are R461I, I462S, G463E, ...
... craniopharyngioma, some types of glioma); whilst calcification in such normal structures as the pineal body, the choroid ...
Augmented Reality: Path guidance to craniopharyngioma on YouTube Manhas S, Vizet J, Deby S, Vanel J, Boito P, Verdier M, De ...
... and a diagnosis of craniopharyngioma. Apart from cardiovascular disease, this study also showed an increased risk of death from ...
If originating superior to the optic chiasm, more commonly in a craniopharyngioma of the pituitary stalk, the visual field ...
... especially craniopharyngioma damage to the pituitary from radiation therapy to the head (e.g. for leukemia or brain tumors), ...
... craniopharyngioma MeSH C04.557.465.625.600 --- neoplasms, neuroepithelial MeSH C04.557.465.625.600.355 --- ganglioneuroma MeSH ... craniopharyngioma MeSH C04.557.580.625.600 --- neoplasms, neuroepithelial MeSH C04.557.580.625.600.355 --- ganglioneuroma MeSH ...
6.1 Craniopharyngioma (ICD-O 9350/1, WHO grade I) 6.2 Granular cell tumour (ICD-O 9582/0, WHO grade I) 6.3 Pituicytoma (ICD-O ...
Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma. The safety and scientific ... Craniopharyngioma. Adamantinoma. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. ... Histologically proven papillary craniopharyngioma as documented by central pathology review with positive BRAF V600E mutation ... BRAF V600E Mutation Present Papillary Craniopharyngioma Drug: Vemurafenib Drug: Cobimetinib Other: Laboratory Biomarker ...
Childhood craniopharyngioma - current status and recent perspectives in diagnostics and treatment by Müller, Hermann L. ... A 17-year-old boy who was diagnosed with craniopharyngioma at the age of 10 years and underwent tumor resection and gamma knife ... Hypodipsic hypernatremia leading to reversible renal failure following surgery for craniopharyngioma. Ah Reum Kwon*Institute of ... To our knowledge, this is the first report of decreased thirst sensation secondary to craniopharyngioma and tumor resection ...
Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults. ... RF, MB, JF, DC and AvD provided craniopharyngioma samplesfor this study. RB, AH, DJ, SP, MS and MM initiated this study and ... Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up. Expert Rev Neurother ... Prieto R, Pascual JM, Subhi-Issa I, Jorquera M, Yus M, Martinez R. Predictive factors for craniopharyngioma recurrence: a ...
keywords = "Cell kinetics, Cell proliferation, Craniopharyngioma, Ki-67, MIB-1",. author = "Ravi Raghavan and Dickey, {William ...
A craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland. ... A craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland. ... Pituitary tumors and craniopharyngioma. In: Gunderson LL, Tepper JE, eds. Clinical Radiation Oncology. 4th ed. Philadelphia, PA ... Usually, surgery has been the main treatment for craniopharyngioma. However, radiation treatment instead of surgery or along ...
Treatment for papillary craniopharyngioma. An uncommon type of craniopharyngioma called papillary craniopharyngioma may respond ... Craniopharyngioma is a rare type of noncancerous (benign) brain tumor.. Craniopharyngioma begins near the brains pituitary ... Tests and procedures used to diagnose craniopharyngioma include:. *Physical exam. Diagnosing a craniopharyngioma usually starts ... Craniopharyngioma treatment options include:. *. Surgery. Surgery to remove all or most of the tumor is most often recommended ...
encoded search term (Craniopharyngioma) and Craniopharyngioma What to Read Next on Medscape. Related Conditions and Diseases. * ... Craniopharyngioma. Updated: Dec 11, 2017 * Author: George I Jallo, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, ... A craniopharyngioma is a slow-growing, extra-axial, epithelial-squamous, calcified, and cystic tumor arising from remnants of ... Kobayashi T, Kida Y, Mori Y, Hasegawa T. Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 ...
encoded search term (Craniopharyngioma) and Craniopharyngioma What to Read Next on Medscape. Related Conditions and Diseases. * ... Craniopharyngioma Clinical Presentation. Updated: Dec 11, 2017 * Author: George I Jallo, MD; Chief Editor: Tarakad S ... The following relationships are seen between the anatomic location of the craniopharyngioma and major clinical syndromes:. * ... Kobayashi T, Kida Y, Mori Y, Hasegawa T. Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 ...
A craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland. ... Pituitary tumors and craniopharyngioma. In: Gunderson LL, Tepper JE, eds. Clinical Radiation Oncology. 4th ed. Philadelphia, PA ... Usually, surgery has been the main treatment for craniopharyngioma. However, radiation treatment instead of surgery or along ... There may be long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. ...
"Craniopharyngioma - Childhood: Diagnosis , Cancer.Net". Cancer.Net. 2012-06-25. Retrieved 2017-12-09. "Craniopharyngioma". UCLA ... Cancer.Net: Craniopharyngioma - Childhood Boston Neurosurgical Foundation Adamantinomatous Craniopharyngioma Malignant ... "Mayfield". Use of surgical navigation for craniopharyngioma removal[dead link] Wisoff, JH (Feb 2008). "Craniopharyngioma". ... Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs most commonly in children ...
Here, we report a case of leaking cystic craniopharyngioma presenting with recurrent... ... Recurrent chemical meningitis from cyclic leakage of cyst content from a craniopharyngioma is a rare phenomenon. ... 2011) Craniopharyngioma in [Youmans JR, Winn HR]. Youmans Neurological Surgery. SaundersGoogle Scholar ... Satoh H, Uozumi T, Arita K et al (1993) Spontaneous rupture of craniopharyngioma cysts. A report of five cases and review of ...
Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors.. Kim SK, Wang KC, Shin SH, Choe G, ... Long term results of multimodality treatment of craniopharyngioma in children. Vernet O, Montes JL, Farmer JP, Blundell JE, ... The role of radiation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature. ... Hormonal factors influencing weight and growth pattern in craniopharyngioma. Pinto G, Bussieres L, Recasens C, Souberbielle JC ...
www.braintumor.org > Your Voice > Share Your Story > Surviving a craniopharyngioma. Surviving a craniopharyngioma. ... Through a group on Facebook of fellow craniopharyngioma survivors they were told about a study at St. Judes on her tumor that ...
Maximum tolerated dose (MTD) of RO4929097 determined according to dose-limiting toxicities (DLTs) graded using Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0 ...
Get detailed information about treatment of newly diagnosed and recurrent childhood craniopharyngioma in this summary for ... Treatment options for children with craniopharyngioma include surgery, radiation therapy, cyst drainage, intracavitary ... Newly Diagnosed Childhood Craniopharyngioma Treatment. Treatment Options for Newly Diagnosed Childhood Craniopharyngioma. There ... Recurrent Childhood Craniopharyngioma Treatment. Treatment Options for Recurrent Childhood Craniopharyngioma. Recurrence of ...
Read about the journeys of our patients with Craniopharyngioma from experts at Boston Childrens, ranked best Childrens ...
Results: Of 142 unique references x referred to substances used for intracystic craniopharyngioma treatment. General aspects of ... Results: Of 142 unique references x referred to substances used for intracystic craniopharyngioma treatment. General aspects of ... Craniopharyngioma of childhood are commonly cystic in nature. An intracystic catheter insertion and subsequent instillation of ... Craniopharyngioma of childhood are commonly cystic in nature. An intracystic catheter insertion and subsequent instillation of ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Craniopharyngioma remains a challenging entity for neurosurgeons because of its midline, deep seated location and intimate ... Garnett MR, Puget S, Grill J, Sainte-Rose C (2007) Craniopharyngioma. Orphanet J Rare Dis 2:18. doi: 10.1186/1750-1172-2-18 ... Queirós J, Magalhães Â, Medina JL (2007) Craniopharyngioma: same dangers, different age. Endocrinol Nutr 54(3):131-133CrossRef ... Craniopharyngioma remains a challenging entity for neurosurgeons because of its midline, deep seated location and intimate ...
Recurrent Childhood Craniopharyngioma. Recurrent craniopharyngioma is a tumor that has recurred (come back) after it has been ... Recurrent Childhood Craniopharyngioma. Craniopharyngioma may recur (come back) no matter how it was treated the first time. ... Stages of Childhood Craniopharyngioma. Recurrent Childhood Craniopharyngioma. Treatment Option Overview. Treatment Options for ... Newly Diagnosed Childhood Craniopharyngioma. Treatment of newly diagnosed childhood craniopharyngioma may include the following ...
Craniopharyngioma Craniopharyngiomas are intracranial tumors that are typically both cystic and solid in structure. They occur ... The best means of visualizing a craniopharyngioma is with a MRI or CT scan of the pituitary region performed without and with ... The initial treatment for a craniopharyngioma is usually surgery. The goal of surgery is to completely remove the tumor while ... The symptoms produced by a craniopharyngioma vary depending upon the tumors location. If it compresses the pituitary stalk or ...
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, Medication, or Diagnosis ... Craniopharyngioma Print Images (3) Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD. Other ... A craniopharyngioma is a brain tumor arising from pituitary embryonic tissue. It is typically suprasellar and has solid and ...
... remains the mainstay of multidisciplinary management of patients with incompletely resected and recurrent craniopharyngioma. ... Brada M, Thomas G (1993) Craniopharyngioma revisited. Int J Radiat Oncol Biol Phys 27(2):471-475PubMedCrossRefGoogle Scholar ... Craniopharyngioma Radiotherapy Radiosurgery Stereotactic radiotherapy IMRT This is a preview of subscription content, log in to ... Niranjan A, Kano H, Mathieu D et al (2010) Radiosurgery for craniopharyngioma. Int J Radiat Oncol Biol Phys 78(1):64-71PubMed ...
The most likely cause of sellar lesions in this age group are adamantinomatous craniopharyngioma (adaCP) or Rathke`s cleft ... This important result documents a supposable transition of RCC metaplasia into a papillary craniopharyngioma (papCP). Secondly ... This important result documents a supposable transition of RCC metaplasia into a papillary craniopharyngioma (papCP). Secondly ... The most likely cause of sellar lesions in this age group are adamantinomatous craniopharyngioma (adaCP) or Rathke`s cleft ...
Childhood Craniopharyngioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] ... Recurrent Childhood Craniopharyngioma Treatment. Treatment Options for Recurrent Childhood Craniopharyngioma Recurrence of ... Newly Diagnosed Childhood Craniopharyngioma Treatment. Treatment Options for Newly Diagnosed Childhood Craniopharyngioma ... Newly Diagnosed Childhood Craniopharyngioma Treatment Added text to state that an understanding of the complex variations in ...
  • To determine the activity of BRAF and MEK inhibitor combination in papillary craniopharyngiomas as measured by response of enhancing volume of craniopharyngioma. (clinicaltrials.gov)
  • A craniopharyngioma is a slow-growing, extra-axial, epithelial-squamous, calcified, and cystic tumor arising from remnants of the craniopharyngeal duct and/or Rathke cleft and occupying the sellar/suprasellar region. (medscape.com)
  • Craniopharyngioma is a rare, usually suprasellar neoplasm, which may be cystic, that develops from nests of epithelium derived from Rathke's pouch. (wikipedia.org)
  • CT showed a cystic suprasellar mass with calcification diagnostic of craniopharyngioma. (ispub.com)
  • CT scan showed a heavily calcified suprasellar lesion consistent with craniopharyngioma, with a slightly hyperdense, well defined portion extending superiorly through the third ventricle and abutting the Foramen of Monroe and associated dilation of the left lateral ventricle (figure 1). (ispub.com)
  • Recurrent chemical meningitis from cyclic leakage of cyst content from a craniopharyngioma is a rare phenomenon. (springer.com)
  • Rajput D, Srivastva A, Kumar R, Mahapatra A (2012) Recurrent chemical meningitis in craniopharyngioma without reduction in size of cyst: case report of two cases and review of the literature. (springer.com)
  • Kulkarni V, Daniel RT, Pranatartiharan R (2000) Spontaneous intraventricular rupture of craniopharyngioma cyst. (springer.com)
  • Patrick BS, Smith RR, Bailey TO (1974) Aseptic meningitis due to spontaneous rupture of craniopharyngioma cyst. (springer.com)
  • Expression of Hard a-Keratins in Pilomatrixoma, Craniopharyngioma, and Calcifying Odontogenic Cyst. (thedoctorsdoctor.com)
  • Hence the prospect of a minimally invasive intervention - such as an endoscopic insertion of a catheter with a subcutanous Ommaya reservoir - and subsequent instillation of substances inducing shrinkage of the craniopharyngioma cyst(s), seems a promising strategy. (frontiersin.org)
  • The search strategy comprised a text search with medical subject headings (MeSH) and free text terms used in combination including craniopharyngioma, intracystic treatment, cyst*, antineoplastic, and antibiotic. (frontiersin.org)
  • One cause of postoperative morbidity, and indeed mortality, is aseptic meningitis from spill-out of craniopharyngioma cyst contents. (neurosurgery.directory)
  • They described a technique of using an epidural catheter , inserted into the working channel of a neuroendoscope , to decompress the cystic portion of a craniopharyngioma cyst before opening the cyst wall widely, preventing spill-out of large volumes of cyst content into the ventricular system . (neurosurgery.directory)
  • Analysis of the data obtained for cyst fluids according to Felgenhauer and comparing them to those obtained for the corresponding blood sera led us to prove the hypothesis of blood-brain barrier impairment in patients with cyst formations in craniopharyngioma. (neurosurgery.directory)
  • The most common abnormalities that arise in the pituitary gland are pituitary adenoma, Rathke's cleft cyst and craniopharyngioma. (radiologyassistant.nl)
  • abstract = "A 31-year-old Caucasian male was referred for panhypopituitarism resulting from a surgically removed craniopharyngioma. (elsevier.com)
  • Radiotherapy remains the mainstay of multidisciplinary management of patients with incompletely resected and recurrent craniopharyngioma. (springer.com)
  • Minniti G, Esposito V, Amichetti M et al (2009) The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma. (springer.com)
  • Lin LL, El Naqa I, Leonard JR et al (2008) Long term outcome in children treated for craniopharyngioma with and without radiotherapy. (springer.com)
  • Fractionated Radiotherapy: Multiple doses of low-level radiation levels are administered to the craniopharyngioma, effectively stopping growth or shrinking the tumor. (valleygammaknife.com)
  • One is the embryogenetic theory, which explains the formation of the Rathke cleft, an area where craniopharyngioma may form. (rareshare.org)
  • The craniopharyngioma may disturb the function of the pituitary gland (pituitary gland) and that of its superordinate center (hypothalamus). (the-health-site.com)
  • The craniopharyngioma can also interfere with the fluid balance of the body: it is regulated by the antidiuretic hormone (ADH), which is formed in the hypothalamus, stored in the pituitary gland and then released into the blood as needed. (the-health-site.com)
  • We report a 19-year-old female who was diagnosed with craniopharyngioma, developed hypothalamic obesity after tumor resection, and progressed to hepatopulmonary syndrome. (e-apem.org)
  • We describe a case of hepatopulmonary syndrome complicated with hypothalamic obesity, NAFLD, and type 2 DM after craniopharyngioma resection. (e-apem.org)
  • As a craniopharyngioma slowly grows, it can affect the function of the pituitary gland and other nearby structures in the brain. (mayoclinic.org)
  • To better understand what a craniopharyngioma is and why it is harmful, it helps to understand the function of the pituitary gland, which is part of the endocrine system. (rwjbh.org)
  • During embryonic development, a craniopharyngioma forms from cells that make up a portion of the pituitary gland (a part of the brain responsible for many hormones in the body). (valleygammaknife.com)
  • Patnaik A, Mahapatra AK, Sarkar S, Samal DK (2016) Spontaneous leaking craniopharyngioma causing preoperative chemical meningitis. (springer.com)
  • Craniopharyngioma (CP), a rare benign and slow-growing epithelial tumor, is mainly located within the sellar/parasellar region. (ovid.com)
  • Craniopharyngioma can occur at any age, but it occurs most often in children and older adults. (mayoclinic.org)
  • Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs most commonly in children but also in adults in their 50s and 60s. (wikipedia.org)
  • A craniopharyngioma is a tumor which occurs in the region of the pituitary gland at the base of the brain. (nervous-system-diseases.com)
  • Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs most commonly in children but also in men and women in their 50s and 60s. (rareshare.org)
  • Craniopharyngioma diagnosed by histology, cytology or neuroimaging. (knowcancer.com)
  • She was suspected to have craniopharyngioma on brain magnetic resonance imaging (MRI) and underwent surgical resection with a ventriculoperitoneal shunt. (e-apem.org)
  • There may be long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. (medlineplus.gov)
  • Craniopharyngioma is associated with an increased risk of mortality even after surgical, radiotherapeutic and hormone supplementations. (springer.com)
  • To investigate CVD risk in adults with CO craniopharyngioma on complete hormone replacement, including long-term GH therapy, and to investigate the impact of disease-related factors on CVD risk. (diva-portal.org)
  • Because the pituitary gland secretes hormones, a craniopharyngioma tumor presses against it and affects hormone levels. (rwjbh.org)
  • Growth disorders such as small or large growth can occur when the craniopharyngioma affects the production of growth hormone in the pituitary gland. (the-health-site.com)
  • Overweight and underweight, osteoporosis and increased or decreased hairiness are possible consequences if the craniopharyngioma disturbs the production of the stress hormone cortisol in the adrenal glands by impairing the pituitary gland. (the-health-site.com)
  • Individuals who are cured of craniopharyngioma often experience long-standing hormone, vision, and neurological problems. (rareshare.org)
  • To diagnose a craniopharyngioma, your child's doctor will ask you for a medical history, as well as perform a physical and neurological examination. (rwjbh.org)
  • Craniopharyngioma presenting during pregnancy 4 years after a normal magnetic resonance imaging scan: case report. (thedoctorsdoctor.com)
  • Through a group on Facebook of fellow craniopharyngioma survivors they were told about a study at St. Judes on her tumor that included an experimental form of targeted radiation known as proton therapy. (braintumor.org)
  • Radiation therapy and p53 mutations could be involved in malignant transformation in craniopharyngioma 4) . (neurocirugia.com)