A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.
A species of ENTEROVIRUS infecting humans and containing 36 serotypes. It is comprised of all the echoviruses and a few coxsackieviruses, including all of those previously named coxsackievirus B.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.
Enterovirus Infections are acute viral illnesses caused by various Enterovirus serotypes, primarily transmitted through the fecal-oral route, manifesting as a wide range of clinical symptoms, from asymptomatic or mild self-limiting fever to severe and potentially life-threatening conditions, such as meningitis, encephalitis, myocarditis, and neonatal sepsis-like illness, depending on the age, immune status, and serotype of the infected individual.
A mild, highly infectious viral disease of children, characterized by vesicular lesions in the mouth and on the hands and feet. It is caused by coxsackieviruses A.

T cells contribute to disease severity during coxsackievirus B4 infection. (1/525)

By using a model of coxsackievirus B4-induced disease, the question of whether tissue damage is due to the virus or to immune-mediated mechanisms was addressed. Both viral replication and T-cell function were implicated in contributing to the severity of disease. Three stages (I to III) of disease, which correspond to periods of high viral titers, low viral titers, and no infectious virus, have been identified. Stage I disease is considered to be primarily the result of viral replication. Immunopathological mechanisms appear to contribute to the severity of stage II and III disease. To investigate the role of T cells in contributing to the severity of disease, viral infection in CD8 knockout (ko) mice and CD4 ko mice was analyzed. CD8 T-cell responses appear to be beneficial during early, viral disease but detrimental in later disease when viral titers are diminishing. CD4 ko mice, unlike the parental strain, survived infection. Viral replication was lower in the CD4 ko mice. Was survival due to decreased viral replication or to the lack of T-helper-cell function? To investigate further the role of T helper cells in contributing to tissue damage, viral infection in two additional ko strains (interleukin-4 [IL-4] ko and gamma interferon ko strains) was examined. A clear correlation between viral replication and the outcome of infection was not observed. The absence of IL-4, which may influence T-helper-cell subset development, was advantageous during early viral disease but deleterious in later disease. The results suggest that T-cell-mediated immunity is both beneficial and detrimental during coxsackievirus B4 infection.  (+info)

Viral myocarditis: identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart. (2/525)

Differences in host susceptibility to viral myocarditis caused by a given strain of coxsackievirus B3 (CVB3) are known to be largely related to host genetic factors. Little is known, however, about the key genes that encode determinants (mediators) of myocarditis development or the nature of injury. To identify these genes and further understand the molecular mechanisms of the disease process, we have used a murine model and the differential display technique to fingerprint mRNAs from CVB3-infected mouse hearts. Total RNA was extracted from hearts of 4- and 10-week-old A/J(H-2(a)) mice at day 4 after CVB3 infection, and mRNAs were detected by reverse transcriptase-polymerase chain reaction and subsequently analyzed on polyacrylamide DNA sequencing gels. The differentially displayed bands were confirmed by Northern hybridization using the bands as cDNA probes. Twenty-eight upregulated or downregulated bands were selected from the sequencing gels; among these, 2 upregulated and 3 downregulated cDNA fragments were confirmed by Northern hybridization. DNA sequence analysis and GenBank searching have determined that 4 of the 5 candidate genes are homologous to genes encoding Mus musculus inducible GTPase, mouse mitochondrial hydrophobic peptide (a subunit of NADH dehydrogenase), mouse beta-globin, and Homo sapiens cAMP-regulated response element binding protein (CREB) binding protein (CBP), respectively. The remaining candidate gene matches an unpublished cDNA clone, M musculus Nip21 mRNA (GenBank accession number, AF035207), which is homologous to human Nip2, a Bcl-2 binding protein. Our data suggest preliminarily that both structural and nonstructural genes are involved in myocarditis development. For the structural gene, beta-globin, we further confirmed its downregulation at the protein level by measuring the mean cell volume of red blood cells and found it was marginally reduced in the CVB3-infected group (P<0.06), with no change in hemoglobin concentration. Cardiac myoglobin concentration was also measured and found to be decreased (P<0.005), with a parallel decrease in total soluble protein in the CVB3-infected mouse myocardium (P<0.01). We also noted that the ratio of myoglobin to total protein was not significantly changed; this may be due to the downregulation of additional genes in the host heart, a number being observed on the differential display gels. The significant downregulation of beta-globin major gene expression in the heart may be relevant to impaired cardiac function in both the early and late postinfection period. The other identified nonstructural genes are known to be involved in regulation of gene expression, signal transduction pathways, and apoptotic cell death. The altered expression of structural and nonstructural genes may play important roles in the mediation of myocarditis development and perhaps other pathological processes in the heart.  (+info)

Hormonal regulation of CD4(+) T-cell responses in coxsackievirus B3-induced myocarditis in mice. (3/525)

Coxsackievirus B3 infection causes significant cardiac inflammation in male, but not female, B1.Tg.Ealpha mice. This gender difference in disease susceptibility correlates with selective induction of CD4(+) Th1 (gamma interferon-positive) cell responses in animals with testosterone, whereas estradiol promotes preferential CD4(+) Th2 (interleukin-4 positive [IL-4(+)]) cell responses. Differences in immune deviation of CD4(+) T cells cannot be explained by variation in B7-1 or B7-2 expression. Infection significantly upregulated both molecules, but no differences were detected between estradiol- and testosterone-treated groups. Significantly increased numbers of activated (CD69(+)) T cells expressing the gammadelta T-cell receptor were found in male and testosterone-treated male and female mice. In vivo depletion of gammadelta+ cells by using monoclonal antibodies inhibited myocarditis and resulted in a shift from a Th1 to Th2 response phenotype. Taken together, our results indicate that testosterone promotes a CD4(+) Th1 cell response and myocarditis by promoting increased gammadelta+ cell activation.  (+info)

gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis. (4/525)

Coxsackievirus B3 (CVB3) infection induces myocardial inflammation and myocyte necrosis in some, but not all, strains of mice. C57BL/6 mice, which inherently lack major histocompatibility complex (MHC) class II IE antigen, develop minimal cardiac lesions despite high levels of virus in the heart. The present experiments evaluate the relative roles of class II IA and IE expression on myocarditis susceptibility in four transgenic C57BL/6 mouse strains differing in MHC class II antigen expression. Animals lacking MHC class II IE antigen (C57BL/6 [IA+ IE-] and ABo [IA- IE-]) developed minimal cardiac lesions subsequent to infection despite high concentrations of virus in the heart. In contrast, strains expressing IE (ABo Ealpha [IA- IE+] and Bl.Tg.Ealpha [IA+ IE+]) had substantial cardiac injury. Myocarditis susceptibility correlated to a Th1 (gamma interferon-positive) cell response in the spleen, while disease resistance correlated to a preferential Th2 (interleukin-4-positive) phenotype. Vgamma/Vdelta analysis indicates that distinct subpopulations of gamma delta+ T cells are activated after CVB3 infection of C57BL/6 and Bl.Tg.Ealpha mice. Depletion of gamma delta+ T cells abrogated myocarditis susceptibility in IE+ animals and resulted in a Th1-->Th2 phenotype shift. These studies indicate that the MHC class II antigen haplotype controls myocarditis susceptibility, that this control is most likely mediated through the type of gamma delta T cells activated during CVB3 infection, and finally that different subpopulations of gamma delta+ T cells may either promote or inhibit Th1 cell responses.  (+info)

Activity of pleconaril against enteroviruses. (5/525)

The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly isolated enterovirus serotypes was examined. The latter viruses were isolated by the Centers for Disease Control and Prevention during the 1970s and 1980s from clinically ill subjects. Pleconaril at a concentration of +info)

Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. (6/525)

Viral myocarditis is an important cause of heart failure and dilated cardiomyopathy. T lymphocytes are implicated in myocardial damage in murine models of coxsackievirus B3 (CVB3) myocarditis. We used knockout mice lacking CD4 (CD4(-/-)), CD8 (CD8(-/-)), both coreceptors (CD4(-/-)CD8(-/-)), or the T-cell receptor beta chain (TCRbeta(-/-)) to address the contribution of T-cell subpopulations to host susceptibility to CVB3 myocarditis. Severity of disease was magnified in CD8(-/-) mice but attenuated in CD4(-/-) mice, consistent with a pathogenic role for CD4(+) lymphocytes. Elimination of both CD4 and CD8 molecules from T lymphocytes by genetic knockout better protected mice from myocarditis, demonstrating that both CD4(+) and CD8(+) T cells contribute to host susceptibility. The same benefit occurred in TCRbeta(-/-) mice, with prolonged survival and minimal myocardial disease observed after CVB3 infection. Elevated interferon-gamma and decreased tumor necrosis factor-alpha expression are associated with attenuated myocardial damage in CD4(-/-)CD8(-/-) mice. These results show that the presence of TCRalphabeta(+) T cells enhances host susceptibility to myocarditis. The severity of myocardial damage and associated mortality are dependent on the predominant T-cell type available to respond to CVB3 infection. One mechanism by which CD4(+) and CD8(+) T-cell subsets influence the pathogenesis of myocarditis may involve specific cytokine expression patterns.  (+info)

Coxsackievirus B4 myocarditis in an orangutan. (7/525)

A 37-year-old female orangutan died at the zoological garden. Autopsy examination demonstrated severe coxsackievirus B4 myocarditis immunohistochemically as a cause of the death. Apoptosis of the cardiac muscle cells was observed using the TdT-mediated dUTP-biotin nick endo labeling method and was considered to play a role in the myocarditis. Congestion of the liver and both lungs due to cardiac failure was also observed. Coxsackievirus infection is found frequently in the Okinawan human population. The present orangutan's infection might have come from visitors who were allowed to go near the orangutan. Malignant tumors, severe suppurative infections, and intestinal parasite infections were not observed. Epstein-Barr virus DNA was detected in lymph nodes, but there was no Burkitt's lymphoma.  (+info)

The role of B lymphocytes in coxsackievirus B3 infection. (8/525)

Coxsackieviruses are important human pathogens, frequently causing myocarditis, pancreatitis, and a variety of less severe diseases. B lymphocytes appear central to the interaction between these viruses and their mammalian hosts, because agammaglobulinemic humans, genetically incapable of antibody production, are susceptible to chronic infections by coxsackieviruses and related enteroviruses, such as poliovirus and echovirus. However, recent studies show that Type B coxsackievirus (CVB) infects B lymphocytes soon after infection, suggesting the possibility that these cells may play some role in virus dissemination and/or that the virus may be able to modulate the host immune response. We analyzed the role of B lymphocytes in CVB infection and confirmed that CVB infects B lymphocytes, and extended these findings to show that this is a productive infection involving approximately 1 to 10% of the cells; however, infectious center assays show that other splenocytes are infected at approximately the same frequency. Virus is readily detectable by in situ hybridization in the spleen of immunocompetent mice but is difficult to detect in mice deficient in B cells (BcKO mice), consistent with much of the splenic signal being the result of B cell infection. Surprisingly, given the extent of their infection, B cells express barely detectable levels of the murine coxsackievirus-adenovirus receptor (mCAR), suggesting that another means of cell entry may be used. We found no evidence of B cell depletion following CVB infection, indicating that this is not the explanation for the transient immunosuppression previously reported. Virus replication and dissemination are slightly delayed in BcKO mice, consistent with B cells' playing a role as an important early target of infection and/or a means to distribute the virus to many tissues. In addition, we show that BcKO mice recapitulate a central feature of human agammaglobulinemia: CVB establishes chronic infection in a variety of organs (heart, liver, brain, kidney, lung, pancreas, spleen). In most of these tissues the viral titers remain high (10(5)-10(8) plaque forming units (pfu) per gram of tissue) for the life of the mouse, and in several there is severe pathology, particularly severe myocardial fibrosis with ventricular dilation, reminiscent of the dilated cardiomyopathy seen in humans with chronic enteroviral myocarditis. Transfer of B and/or T cells from non-immune mice had no discernible effect, whereas equivalent transfers from immune mice often resulted in transient or permanent disappearance of detectable CVB.  (+info)

Coxsackievirus infections are a type of viral illness caused by Coxsackie A and B viruses, which belong to the family Picornaviridae. These viruses can cause a wide range of symptoms, depending on the specific strain and the age and overall health of the infected individual.

The most common types of Coxsackievirus infections are hand, foot, and mouth disease (HFMD) and herpangina. HFMD is characterized by fever, sore throat, and a rash that typically appears on the hands, feet, and mouth. Herpangina is similar but is usually marked by painful sores in the back of the mouth or throat.

Other possible symptoms of Coxsackievirus infections include:

* Fever
* Headache
* Muscle aches
* Fatigue
* Nausea and vomiting
* Abdominal pain

In some cases, Coxsackievirus infections can lead to more serious complications, such as meningitis (inflammation of the membranes surrounding the brain and spinal cord), myocarditis (inflammation of the heart muscle), or pleurodynia (also known as "devil's grip," a painful inflammation of the chest and abdominal muscles).

Coxsackievirus infections are typically spread through close contact with an infected person, such as through respiratory droplets or by touching contaminated surfaces. The viruses can also be spread through fecal-oral transmission.

There is no specific treatment for Coxsackievirus infections, and most people recover on their own within a week or two. However, severe cases may require hospitalization and supportive care, such as fluids and pain relief. Prevention measures include good hygiene practices, such as washing hands frequently and avoiding close contact with sick individuals.

Enterovirus B, Human (HEVB) is a type of enterovirus that infects humans. Enteroviruses are small viruses that belong to the Picornaviridae family and are named after the Greek word "pico" meaning small. They are further classified into several species, including Human Enterovirus B (HEV-B).

HEVB includes several serotypes, such as Coxsackievirus A9, A16, and B types, and Echoviruses. These viruses are typically transmitted through the fecal-oral route or respiratory droplets and can cause a range of illnesses, from mild symptoms like fever, rash, and sore throat to more severe diseases such as meningitis, myocarditis, and paralysis.

HEVB infections are common worldwide, and people of all ages can be affected. However, young children and individuals with weakened immune systems are at higher risk for severe illness. Prevention measures include good hygiene practices, such as washing hands frequently and avoiding close contact with sick individuals. There is no specific treatment for HEVB infections, and most cases resolve on their own within a few days to a week. However, hospitalization may be necessary for severe cases.

An enterovirus is a type of virus that primarily infects the gastrointestinal tract. There are over 100 different types of enteroviruses, including polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses such as EV-D68 and EV-A71. These viruses are typically spread through close contact with an infected person, or by consuming food or water contaminated with the virus.

While many people infected with enteroviruses may not experience any symptoms, some may develop mild to severe illnesses such as hand, foot and mouth disease, herpangina, meningitis, encephalitis, myocarditis, and paralysis (in case of poliovirus). Infection can occur in people of all ages, but young children are more susceptible to infection and severe illness.

Prevention measures include practicing good hygiene, such as washing hands frequently with soap and water, avoiding close contact with sick individuals, and not sharing food or drinks with someone who is ill. There are also vaccines available to prevent poliovirus infection.

Myocarditis is an inflammation of the myocardium, which is the middle layer of the heart wall. The myocardium is composed of cardiac muscle cells and is responsible for the heart's pumping function. Myocarditis can be caused by various infectious and non-infectious agents, including viruses, bacteria, fungi, parasites, autoimmune diseases, toxins, and drugs.

In myocarditis, the inflammation can damage the cardiac muscle cells, leading to decreased heart function, arrhythmias (irregular heart rhythms), and in severe cases, heart failure or even sudden death. Symptoms of myocarditis may include chest pain, shortness of breath, fatigue, palpitations, and swelling in the legs, ankles, or abdomen.

The diagnosis of myocarditis is often based on a combination of clinical presentation, laboratory tests, electrocardiogram (ECG), echocardiography, cardiac magnetic resonance imaging (MRI), and endomyocardial biopsy. Treatment depends on the underlying cause and severity of the disease and may include medications to support heart function, reduce inflammation, control arrhythmias, and prevent further damage to the heart muscle. In some cases, hospitalization and intensive care may be necessary.

The Coxsackie and Adenovirus Receptor (CAR) is a transmembrane protein that serves as a receptor for several viruses, including Coxsackieviruses and certain types of Adenoviruses. The "Coxsackie and Adenovirus Receptor-Like Membrane Protein" likely refers to a membrane protein that shares structural or functional similarities with the CAR protein.

The CAR protein is a member of the immunoglobulin superfamily and is widely expressed in various tissues, including the heart, lungs, and nervous system. It plays important roles in cell adhesion, tissue development, and repair, as well as serving as an entry point for certain viruses to infect cells.

The CAR-like membrane protein may have similar functions or structures to the CAR protein, but its specific identity and role are not clearly defined in the medical literature. It is possible that it could be a target for viral infection or play a role in cellular processes, but further research is needed to confirm these possibilities.

Enterovirus infections are viral illnesses caused by enteroviruses, which are a type of picornavirus. These viruses commonly infect the gastrointestinal tract and can cause a variety of symptoms depending on the specific type of enterovirus and the age and overall health of the infected individual.

There are over 100 different types of enteroviruses, including polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses such as EV-D68 and EV-A71. Some enterovirus infections may be asymptomatic or cause only mild symptoms, while others can lead to more severe illnesses.

Common symptoms of enterovirus infections include fever, sore throat, runny nose, cough, muscle aches, and skin rashes. In some cases, enteroviruses can cause more serious complications such as meningitis (inflammation of the membranes surrounding the brain and spinal cord), encephalitis (inflammation of the brain), myocarditis (inflammation of the heart muscle), and paralysis.

Enterovirus infections are typically spread through close contact with an infected person, such as through respiratory droplets or fecal-oral transmission. They can also be spread through contaminated surfaces or objects. Preventive measures include good hygiene practices, such as washing hands frequently and avoiding close contact with sick individuals.

There are no specific antiviral treatments for enterovirus infections, and most cases resolve on their own within a few days to a week. However, severe cases may require hospitalization and supportive care, such as fluids and medication to manage symptoms. Prevention efforts include vaccination against poliovirus and surveillance for emerging enteroviruses.

Hand, foot, and mouth disease (HFMD) is a mild, contagious viral infection common in infants and children but can sometimes occur in adults. The disease is often caused by coxsackievirus A16 or enterovirus 71.

The name "hand, foot and mouth" comes from the fact that blister-like sores usually appear in the mouth (and occasionally on the buttocks and legs) along with a rash on the hands and feet. The disease is not related to foot-and-mouth disease (also called hoof-and-mouth disease), which affects cattle, sheep, and swine.

HFMD is spread through close personal contact, such as hugging and kissing, or through the air when an infected person coughs or sneezes. It can also be spread by touching objects and surfaces that have the virus on them and then touching the face. People with HFMD are most contagious during the first week of their illness but can still be contagious for weeks after symptoms go away.

There is no specific treatment for HFMD, and it usually resolves on its own within 7-10 days. However, over-the-counter pain relievers and fever reducers may help alleviate symptoms. It's important to encourage good hygiene practices, such as handwashing and covering the mouth and nose when coughing or sneezing, to prevent the spread of HFMD.

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Coxsackieviruses share many characteristics with poliovirus. With control of poliovirus infections in much of the world, more ... The coxsackieviruses subsequently were found to cause a variety of infections, including epidemic pleurodynia (Bornholm disease ... 2004). "Evidence for Coxsackievirus Infection in Primary Sjogren's Syndrome". Arthritis & Rheumatism. 50 (9): 2897-2902. doi: ... Dalldorf G, Gifford R (January 1954). "Susceptibility of gravid mice to Coxsackie virus infection". J. Exp. Med. 99 (1): 21-7. ...
"Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy". Group B ... and coxsackievirus A15 is the same serotype as coxsackievirus A11 and coxsackievirus A18 is the same serotype as coxsackievirus ... Chapman, N. M.; Kim, K. S. (2008). "Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and ... Enterovirus B includes coxsackievirus B1,2,3,4,5,6; coxsackievirus A9; echovirus 1-33 and enterovirus B69-113. Coxsackie B ...
Ren LQ, Li XJ, Li GS, Zhao ZT, Sun B, Sun F (November 2004). "Coxsackievirus B3 infection and its mutation in Keshan disease". ... Beck MA, Levander OA, Handy J (May 2003). "Selenium deficiency and viral infection". J. Nutr. 133 (5 Suppl 1): 1463S-7S. doi: ... Current research suggests that the lack of selenium results in a more virulent strain of the coxsackievirus becoming the ... In addition, an individual can experience eczema, psoriasis, arthritis, cataracts, alcoholism, and infections.[citation needed ...
"Clinical features of coxsackievirus A4, B3, and B4 infections in children". PLOS ONE. 9 (2): e87391. Bibcode:2014PLoSO... ... The chest x-ray showed bilateral pleural effusions which resolved after infection. The erythrocyte sedimentation rate (ESR) and ... Schmidt NJ, Magoffin RL, Lennette EH (September 1973). "Association of group B coxsackie viruses with cases of pericarditis, ... An outbreak associated with coxsackievirus B1". JAMA. 270 (18): 2205-6. doi:10.1001/jama.270.18.2205. PMID 8411604. Weller, TH ...
"Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy". Group B ... Coxsackie B infections have been reported to account for nearly a quarter of all enterovirus infections. Nearly half of all ... Chapman, N. M.; Kim, K. S. (2008). "Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and ... Coxsackie B3 (CB3) infections are the most common enterovirus cause of myocarditis and sudden cardiac death. CB3 infection ...
"Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells". The Journal of ... "Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells". Inflammation Research. 63 (4): 267-76. doi: ... "Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor". Nature Structural Biology. 8 (10): ... Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. The protein encoded by ...
Acquired diseases include mumps orchitis, Coxsackievirus B infection, irradiation, chemotherapy, or trauma; all problems ...
"Fatal Infection in an Infant Associated with Coxsackie Virus Group A, Type 16". New England Journal of Medicine. 268 (19): 1041 ... Schmidt, N. J.; Ho, H. H.; Lennette, E. H. (1975). "Propagation and isolation of group a coxsackieviruses in RD cells". Journal ... Lennette, E. H.; Koprowski, H. (1944). "Influence of age on the susceptibility of mice to infection with certain neurotropic ... Lennette and Koprowski published important findings on the influences of murine age on several murine viral infections and on ...
November 2020). "Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes". ... Coxsackievirus B3 viral proteinase 3C can proteolytically process ULK1 by cleaving after glutamine (Q) residue 524, separating ...
Herzum M, Ruppert V, Küytz B, Jomaa H, Nakamura I, Maisch B (July 1994). "Coxsackievirus B3 infection leads to cell death of ... sCAR-Fc (Soluble Receptor Analogue) is an experimental prophylactic treatment against coxsackievirus B3 (CVB) infections. ... September 2009). "Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic ... April 2004). "Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and ...
They followed a series of epidemics of Coxsackie virus infection in their part of France. After each epidemic there were ... Jan 1997). "Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as ... They were able to culture Coxsackie virus from the tissues of many of the cases at all stages of this apparent progression. A ... Evidence gradually accumulated as to the role of infection as one such type of stress. The studies of Fruhling and colleagues ...
... is a painful mouth infection caused by coxsackieviruses. Usually, herpangina is produced by one particular strain of coxsackie ... virus A (and the term "herpangina virus" refers to coxsackievirus A), but it can also be caused by coxsackievirus B or ...
... in combination with Coxsackievirus infection can lead to Keshan disease, which is potentially fatal. ...
Infection can lead to beta cell apoptosis which increases the risk of insulitis. Coxsackievirus B4 is one of the six serotypes ... 2012). "Outcome of challenge with coxsackievirus B4 in young mice after maternal infection with the same virus during gestation ... A 2004 systematic review analyzing a possible association between coxsackievirus B infection and type 1 diabetes was ... Coxsackieviruses have two groups, A and B, each associated with different diseases. Coxsackievirus group A is known for causing ...
Some patients had also an onset of severe disease in infancy like infection with RSV, norovirus, coxsackievirus, adenovirus or ... CMV and VZV infections were severe as well in few patients. The virus infection was treated by high-dose of intravenous ... Therefore complete AR STAT2 deficiency usually causes disseminated LAV infection and recurrent natural viral infections. ... From the age 5 years, the frequency and severity of viral infections decreased and the age of 10 years the patients were mostly ...
Pericarditis: This condition can be the result of viral infection such as coxsackie virus and echovirus, tuberculosis, ...
In a mouse model of viral myocarditis due to Coxsackievirus infection, CAP/Ponsin stabilized antiviral type I interferon ...
In chronic murine infection, the percentage of infected cardiomyocytes are much lower. Unlike in the DMD, in coxsackievirus ... In a mouse model, at the acute stage (7 days after infection with coxsackievirus B3) approximately 10% of the myocytes are ... Coxsackievirus shows a cardiac tropism partly due to the high expression of coxsackievirus and adenovirus receptors (CAR) in ... acute enterovirus infections such as Coxsackievirus B3 have been identified as the cause of virally induced acute myocarditis, ...
... severe and are more likely to have neurologic or cardiac complications including death than infections caused by Coxsackievirus ... Coxsackievirus A16 is the most common cause of HFMD. Enterovirus 71 (EV-71) is the second-most common cause. Many other strains ... Other strains of coxsackievirus and enterovirus can also be responsible. Some people may carry and pass on the virus despite ... Infection in older children, adolescents, and adults is typically mild and lasts approximately 1 week, but may occasionally run ...
... herpes simplex virus-2 or neonatal herpes simplex Other infections include: Parvovirus B19 Coxsackievirus Chickenpox (caused by ... For many infections, the baby is more at risk at particular stages of pregnancy. Problems related to perinatal infection are ... A vertically transmitted infection is an infection caused by pathogenic bacteria or viruses that use mother-to-child ... The term congenital infection can be used if the vertically transmitted infection persists after childbirth.[citation needed] ...
... syndrome Hyperthyroidism Hypothyroidism Pheochromocytoma Glucagonoma Infections Cytomegalovirus infection Coxsackievirus B ... Diabetic animals are more prone to infections. The long-term complications recognized in humans are much rarer in animals. The ... Petzold A, Solimena M, Knoch KP (October 2015). "Mechanisms of Beta Cell Dysfunction Associated With Viral Infection". Current ... such as a viral infection or diet. Several viruses have been implicated, but to date there is no stringent evidence to support ...
Eczema and psoriasis Deep telangiectasias Coxsackievirus A infection (Hand, foot and mouth disease) Rocky Mountain spotted ...
... suggesting that Telethonin may be involved in the mechanism underlying Coxsackievirus B3 infection in acute and chronic ... "Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection". ... "Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection". ...
This condition typically causes chest pain that may spread to the back, and is often caused by a viral infection (glandular ... fever, cytomegalovirus, or coxsackievirus). Fluid can build up within the pericardial sac, referred to as a pericardial ... but may also be caused by infection of the heart valves (endocarditis). In some parts of the world rheumatic heart disease is a ... and to protect the heart from infection. Heart tissue, like all cells in the body, needs to be supplied with oxygen, nutrients ...
The condition can occur following infection of an unborn baby with rubella, cytomegalovirus, toxoplasmosis, or coxsackie virus ... Other TORCH infections that can cause this rash include cytomegalovirus, herpes virus, and toxoplasma. Blood disorders, such as ... Syphilis: bacterial TORCH infection due to Treponema pallidum. Congenital syphilis can present with saber shins, saddle-shaped ... Rubella: viral TORCH infection associated with post-auricular and occipital lymphadenopathy in addition to a maculopapular rash ...
... may be involved in responses to viral infections such as the enteroviruses coxsackievirus B and poliovirus in epithelial ... and influences the replication of coxsackievirus B; when BPIFB3 is knocked out in experimental systems coxsackievirus B ... Like other BPI-fold family members involved in defense from infection, ... "BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation ...
Hand, Foot, and Mouth Disease: A highly contagious viral infection which infects young children and is caused by Coxsackie ... Oral fungal infections are most commonly caused by different Candida species such as Candida Albicans, Candida Glabrata and ... Chicken Pox: A type of viral infection which is caused by Varicella Zoster Virus and presents in children. Numerous itchy ... They may be mistaken for papilloma or verrucous leukoplakia but are benign (1). Syphilis- Bacterial infection which is usually ...
Pericarditis is often caused by a viral infection (glandular fever, cytomegalovirus, or coxsackievirus), or more rarely with a ... The pericardium sets the heart in mediastinum and limits its motion, protects it from infection, lubricates it and prevents ... It separates the heart from interference of other structures, protects it against infection and blunt trauma, and lubricates ... bacterial infection, but may also occur following a myocardial infarction. Pericarditis is usually a short-lived condition that ...
Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China. Emerging Infectious Diseases. 2012;18(5):821- ... Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China On This Page ... Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China. Emerg Infect Dis. 2012;18(5):821-824. https ... Coxsackievirus A21, Enterovirus 68, and Acute Respiratory Tract Infection, China. Volume 18, Number 5-May 2012 ...
"Infections with Coxsackie virus B5 in six midwestern States" 73, no. 6 (1958). Chin, Tom D. Y. et al. "Infections with ... 1958). Infections with Coxsackie virus B5 in six midwestern States. 73(6). Chin, Tom D. Y. and Greene, John C. and Wenner, ... Title : Infections with Coxsackie virus B5 in six midwestern States Personal Author(s) : Chin, Tom D. Y.;Greene, John C.;Wenner ... Coxsackie virus B5 in six midwestern States" vol. 73, no. 6, 1958. Export RIS Citation Information.. ...
Coxsackieviruses belong to the family Picornaviridae and the genus Enterovirus, which also includes poliovirus and echovirus. ... The CDC found that coxsackievirus infections accounted for approximately 25% of all neonatal enterovirus infections (26,737) ... 4] Coxsackieviruses have been identified in the respiratory tract up to 3 weeks after initial infection and in feces up to 8 ... Coxsackievirus infections occur in all age groups but are more common in young children and infants. Children are at higher ...
Hand-foot-mouth disease is a common viral infection that most often begins in the throat. ... Hand-foot-mouth disease is a common viral infection that most often begins in the throat. ... Antibiotics do not work because the infection is caused by a virus. (Antibiotics treat infections caused by bacteria, not ... Coxsackieviruses, echoviruses, and numbered enteroviruses (EV-A71, EVD-68, EVD-70). In: Bennett JE, Dolin R, Blaser MJ, eds. ...
Enteroviral infections (i.e., Group A and B Coxsackie viruses and Echo viruses) (excludes polio virus) ... Infection/Condition. Type of Precaution. Duration of Precaution. Precautions/Comments. Urinary tract infection (including ... Infection/Condition. Type of Precaution. Duration of Precaution. Precautions/Comments. Parainfluenza virus infection, ... Infection/Condition. Type of Precaution. Duration of Precaution. Precautions/Comments. Ebola virus (see Viral Hemorrhagic ...
May 2012). "Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71". Journal of Virology. 86 ( ... Yu, Weiming; Tellier, Raymond; Wright, James R. (2015). "Coxsackie Virus A16 Infection of Placenta with Massive Perivillous ... Sharma V, Rohrbough SN, Goessling LS, Brar AK, Eghtesady P (2019-11-19). "Abstract 17090: Perinatal Coxsackievirus B4 Infection ... Modlin JF (June 1988). "Perinatal echovirus and group B coxsackievirus infections". Clinics in Perinatology. 15 (2): 233-46. ...
Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to ... Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to ...
... certain viral infections (coxsackie virus, rotavirus, mumps); BMI above 25; high blood pressure (140/90 or higher); high ... The major types of pneumococcal disease are pneumonia (lung infection), bacteremia (blood infection), and meningitis (infection ... Syphilis is a sexually transmitted infection that can have very serious complications when left untreated.^. Get tested for ... Every flu season is different, and influenza infection can affect people differently.^. Everyone over six months of age should ...
Categories: Coxsackievirus Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Group B Coxsackievirus infections in NOD mice: Towards clarifying a role of enteroviruses in human type 1 diabetes onset, S, ... Group B coxsackievirus infections in NOD mice: towards clarifying the role of enteroviruses in human type 1 diabetes onset. 11 ... Coxsackievirus infections and NOD mice: Relevant models of protection from, and induction of, Type 1 Diabetes. 1130, p. 143-151 ... Drescher KM, Kono K, Bopemagamage S, Carson SD, Tracy S Coxsackievirus B3 infection and type 1 diabetes development in NOD mice ...
... families cause the most common primary viral infections of the oral cavity. HPV infections have received particular attention ... This article discusses viral conditions of the oral cavity, including HHV infection, HPV infection, coxsackievirus infection, ... group B coxsackieviruses, and echoviruses. Group A coxsackieviruses comprise 23 serotypes, and group B coxsackieviruses ... Infections - Parainfluenza 3 virus, coxsackievirus, influenza A virus, CMV, Staphylococcus aureus (suppurative parotitis), or ...
Yu, W., Tellier, R., & Wright, J. R. (2015, July 1). Coxsackie virus A16 infection of placenta with massive perivillous fibrin ... Coxsackieviruses are the most common type of enterovirus linked to HFMD, especially coxsackievirus A16. Enterovirus 71 is also ... Scratching at blisters or rashes can lead to a secondary infection.. If blisters develop in the throat, there may be a risk of ... Hand, foot, and mouth disease is the result of a viral infection. It mainly affects children. Symptoms include rashes on the ...
Actual infections with CMV, EBV, HSV, Adenovirus, Coxsackie virus, Toxoplasmosis, HIV and Borellia Burgdorferi were ruled out ... Serology revealed positive anti-Coxsackievirus antibodies, pointing to a currently undergone infection or persistency of ... Infection with Borellia Burgdorferi and Cytomegaly virus (CMV) were serologically evaluated in all patients. 5 patients were ... additionally screened for infections with Epstein Barr Virus (EBV), Herpes simplex virus (bHSV), Adenovirus, Coxsackie virus, ...
First description of herpangina, an acute infection associated with Coxsackie virus. *Synopsis of pediatrics.. With Theodore ...
Viral infections, such as chickenpox , Coxsackie virus, Epstein-Barr, or HIV. *Bacterial infections such as Lyme disease ...
Hand-foot-and-mouth disease is a viral infection most commonly caused by coxsackievirus. Although it can be seen in any age ... Ear Infections in Children. Dr. Jung Smith, Family Medicine Physician. Did you know that more than three out of four children ... Veronica M., Infection Prevention and Employee Health at The Womens Hospital Why should we immunize? The CDC recommends that ... Sexually Transmitted Infections: A Reality That Must Be Discussed. Rebecca Hopper, MD, Pediatrics/Internal Medicine, Deaconess ...
In response, a PSM investigator doubted that a widespread pericarditis-causing viral infection (e.g., coxsackievirus) could ... coxsackievirus infections) are difficult to detect, especially among populations with limited access to medical care. In short ... A panelist added that gathering information on past viral infections is extremely difficult and he doubted whether an alternate ... Commenting on these concerns, an ATSDR scientist said that some infections that might cause pericardial thickening (e.g., ...
... the association between coxsackievirus A7 infection and diabetes has not been discussed in regard to humans. Coxsackievirus A7 ... and a recent infection by coxsackievirus A7 may be associated with the development of β-cell autoantibody-negative insulin- ... coxsackievirus A7-infected pancreatic islet cells have been proved to be a suitable model for studies of experimental infection ... These findings suggest a significant association of coxsackievirus A7 infection for the development of diabetes in our patient. ...
L. Cui, Y. Qi, H. Li et al., "Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections ...
Slam Haplotype 2 Promotes NKT but Suppresses Vg4 T-cell Activation in Coxsackievirus B3 infection Leading to Increased Liver ... "Sex-specific signaling through toll-like receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in ... "Chromosome Y regulates survival following murine coxsackievirus B3 infection." G3: Genes, Genomes, Genetics 2, no. 1 (2012): ... "c-FLIP-Short Reduces Type I Interferon Production and Increases Viremia with Coxsackievirus B3". PLoS ONE 2014 9:5, pages ...
... and coxsackie virus infections.. In comparison with the control group, as well as the tissue from those with influenza and ... coxsackie virus, images of heart tissue from COVID-19 patients showed significant caliber changes of blood-filled capillaries. ...
Infections with Coxsackie virus B5 in six midwestern States Cite CITE. Title : Infections with Coxsackie virus B5 in six ... "Infections with Coxsackie virus B5 in six midwestern States" 73, no. 6 (1958). Chin, Tom D. Y. et al. "Infections with ... 1958). Infections with Coxsackie virus B5 in six midwestern States. 73(6). Chin, Tom D. Y. and Greene, John C. and Wenner, ... Coxsackie virus B5 in six midwestern States" vol. 73, no. 6, 1958. Export RIS Citation Information.. ...
... a genetic barrier and induce autoimmune myocarditis in a strain of mice genetically resistant to infection with coxsackievirus ... The administration of lipopoplysaccharide with coxsackievirus B3 is used to overcome ... in addition to the known mechanisms by which infections elicit autoimmunity, an infectious adjuvant mechanism may play a role ...
and echovirus and coxsackievirus infections (see table ). Manifestations can also resemble Kawasaki disease Kawasaki Disease ... erythema infectiosum Erythema Infectiosum (Parvovirus B19 Infection) Erythema infectiosum is caused by acute infection with ... Pneumonia Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. Initial diagnosis is usually ... Causes, symptoms, treatment, preventive measures, and... read more due to measles virus infection of the lungs occurs in ...
Gonococcal arthritis is caused by infection with the gram-negative diplococcus Neisseria gonorrhoeae . In the United States, ... Disseminated gonococcal infection in a homosexual man diagnosed by nucleic acid amplification testing from a skin lesion swab. ... Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011. Sex Transm Infect. 2013 Dec. ... Gonococcal arthritis (disseminated gonococcal infection). Infect Dis Clin North Am. 2005 Dec. 19(4):853-61. [QxMD MEDLINE Link ...
Molecular evolution of coxsackievirus A24v in Cuba over 23-years, 1986-2009. Fonseca, M. C., Pupo-Meriño, M., García-González, ... Human enteroviral infection impairs autophagy in clonal INS(832/13) cells and human pancreatic islet cells. Wernersson, A., ... Molecular characterization of coxsackievirus a24v from feces and conjunctiva reveals epidemiological links. Fonseca, M. C., ... Diagnostic Testing Accuracy for Helicobacter pylori Infection among Adult Patients with Dyspepsia in Cubas Primary Care ...
Infection with coxsackievirus B4 Type 2 diabetes mellitus has a 100% concordance in identical twins, implying a much stronger ... Infections (such as urinary tract infections, tuberculosis and skin infections). *Deterioration of vision (owing to diabetic ... 355 2.9 3 Urinary tract infection 345 2.8 5 148 1.2 9 197 1.6 9 Skin and subcutaneous tissue infection 342 2.8 6 134 1.1 - 208 ... The presenting complaints of the patients include lack of energy, delayed wound healing, visual blurring and fungal infections ...
Coxsackie (virus) (infection) B34.1 *pharyngitis B08.5 *Herpangina B08.5 *Infection, infected, infective (opportunistic) B99.9 ... Section B00-B09: Viral infections characterized by skin and mucous membrane lesions *Category B08: Other viral infections ... B08.0 Other orthopoxvirus infections *. B08.01 Cowpox and vaccinia not from vaccine. *B08.010 Cowpox ... B08.8 Other specified viral infections characterized by skin and mucous membrane lesions Inclusion term(s): ...
... families cause the most common primary viral infections of the oral cavity. HPV infections have received particular attention ... This article discusses viral conditions of the oral cavity, including HHV infection, HPV infection, coxsackievirus infection, ... group B coxsackieviruses, and echoviruses. Group A coxsackieviruses comprise 23 serotypes, and group B coxsackieviruses ... Infections - Parainfluenza 3 virus, coxsackievirus, influenza A virus, CMV, Staphylococcus aureus (suppurative parotitis), or ...
Coxsackie virus A24 infection presenting as acute flaccid paralysis. The Lancet 357:605. ... Surprisingly, fewer than one in 100 cases (and possibly as few as one in 1,000 cases) of infection with poliovirus produces any ... Since many of those cases showed all the hallmarks of a typical poliovirus infection fever, stiff neck and back, severe ... This fact raises new, disturbing questions, including whether there ever was an epidemic of poliovirus infection in the United ...
  • During August 2006-April 2010, in Beijing, China, 2 rare human enterovirus serotypes, coxsackievirus A21 and enterovirus 68, were detected most frequently in human enterovirus-positive adults with acute respiratory tract infections. (cdc.gov)
  • Thus, during some years, these 2 viruses cause a substantial proportion of enterovirus-associated adult acute respiratory tract infections. (cdc.gov)
  • For instance, in France and Spain, echovirus 11 and echovirus 6 are the predominant serotypes in patients with enterovirus respiratory infections ( 2 , 3 ). (cdc.gov)
  • Clusters of the rare serotype enterovirus 68 (EV68), which causes severe respiratory infections in children, have been recently reported in the Philippines ( 4 ) and Japan ( 5 ). (cdc.gov)
  • We report that in some years in Beijing, People's Republic of China, the rarely reported coxsackievirus A21 (CVA21) and EV68 are the predominant serotypes in adults with enterovirus-associated acute respiratory tract infection (ARTI). (cdc.gov)
  • Coxsackieviruses belong to the family Picornaviridae and the genus Enterovirus , which also includes poliovirus and echovirus. (medscape.com)
  • The CDC found that coxsackievirus infections accounted for approximately 25% of all neonatal enterovirus infections (26,737) from 1983 to 2003. (medscape.com)
  • Similarly, coxsackievirus A6 was the most frequently reported enterovirus from 2009-2013. (medscape.com)
  • Coxsackie A virus (CAV) is a cytolytic Coxsackievirus of the Picornaviridae family, an enterovirus (a group containing the polioviruses, coxsackieviruses, and echoviruses). (wikipedia.org)
  • Coxsackieviruses are the most common type of enterovirus linked to HFMD, especially coxsackievirus A16. (medicalnewstoday.com)
  • Although the precise underlying mechanisms for enterovirus-mediated development of diabetes remain unknown, the systematic review and meta-analysis of observational molecular studies demonstrates a clinically significant association between enteroviral infections detected by molecular methods and type 1 diabetes ( 2 ). (diabetesjournals.org)
  • Coxsackievirus B2, B4, B5, and enterovirus 71 have been reported to be associated with the development of diabetes ( 2 ). (diabetesjournals.org)
  • Meningitis is the leading infectious syndrome that affects the central nervous system, and most cases are caused by viral infections, mainly enterovirus. (bvsalud.org)
  • With control of poliovirus infections in much of the world, more attention has been focused on understanding the nonpolio enteroviruses such as coxsackieviruses. (medscape.com)
  • Hand, foot, and mouth disease (HFMD) is a viral infection caused by enteroviruses. (medicalnewstoday.com)
  • 4×) were significantly elevated, suggesting a history of infections by various enteroviruses. (diabetesjournals.org)
  • types of enteroviruses like coxsackieviruses. (cdc.gov)
  • Coxsackieviruses are nonenveloped viruses with linear single-stranded RNA. (medscape.com)
  • [ 1 ] Coxsackieviruses are divided into group A and group B viruses based on early observations of their pathogenicity in mice. (medscape.com)
  • However, coxsackievirus A16 has been one of the viruses recovered from cerebrospinal fluid in a small number of confirmed cases. (medscape.com)
  • Antibiotics treat infections caused by bacteria, not viruses. (medlineplus.gov)
  • Dr. Marc Horwitz is studying how viruses such as coxsackievirus can induce autoimmune diseases such as chronic heart disease, and how immune system components shape and control development of the disease. (healthresearchbc.ca)
  • These include glandular fever, herpes zoster, chickenpox and any infections caused by coxsackie viruses. (electronicsencyclopedia.com)
  • Complications can lead to bronchiectasis, chronic sinus damage, and also chronic meningoencephalitis due to echoviruses and coxsackieviruses. (lu.se)
  • The CDC reports coxsackievirus A16 as the virus most frequently isolated in hand, foot, and mouth disease (HFMD). (medscape.com)
  • Hand-foot-mouth disease (HFMD) is most commonly caused by a virus called coxsackievirus A16. (medlineplus.gov)
  • Since 2008, coxsackievirus A6 (CVA6) has been associated with several worldwide outbreaks of hand, foot and mouth disease (HFMD). (wikipedia.org)
  • In general, group A coxsackieviruses tend to infect the skin and mucous membranes, causing herpangina , acute hemorrhagic conjunctivitis (AHC), and hand-foot-and-mouth (HFM) disease. (medscape.com)
  • To help clinicians and public health officials better understand the epidemiologic and clinical profiles of HEV respiratory infections, temporal and geographic patterns of circulation, especially the dynamics of HEV serotype shift, need to be determined. (cdc.gov)
  • Most patients with XLA develop recurrent bacterial infections, particularly otitis, sinusitis and pneumonia, in the first two years of life. (lu.se)
  • Approximately 10 million symptomatic enteroviral infections are estimated to occur annually in the United States. (medscape.com)
  • Here we report a case of juvenile-onset insulin-dependent diabetes resulting from various enteroviral infections. (diabetesjournals.org)
  • HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
  • Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children. (cdc.gov)
  • Both group A and group B coxsackieviruses can cause nonspecific febrile illnesses, rashes, upper respiratory tract disease, and aseptic meningitis . (medscape.com)
  • From 2002-2004, an estimated 16.4-24.3% of these illnesses were attributed to coxsackievirus serotypes. (medscape.com)
  • Studies have shown that the body's immune response has a profound effect on the development of chronic heart disease after infection with the virus, revealing that immune cells and antibodies that attack infection also damage heart tissues. (healthresearchbc.ca)
  • Title : Infections with Coxsackie virus B5 in six midwestern States Personal Author(s) : Chin, Tom D. Y.;Greene, John C.;Wenner, Herbert A. (cdc.gov)
  • First description of herpangina, an acute infection associated with Coxsackie virus. (whonamedit.com)
  • Thyroid parameters, a white blood cell count and the determination of CRP were done and infection with Borellia Burgdorferi, Cytomegaly virus (CMV) Epstein Barr Virus (EBV), Herpes simplex virus (HSV), Adenovirus, Coxsackie virus, Toxoplasmosis and Human immunodeficiency virus (HIV) were serologically evaluated. (thieme-connect.de)
  • They compared samples of healthy human heart tissue with the heart tissue of patients who had died from severe forms of COVID-19, influenzas, and coxsackie virus infections. (integrativepractitioner.com)
  • Coxsackie Virus: Herpangina & Hand-Foot-And-MouthAbout half of all children with coxsackie virus infection have no symptoms. (bluefishmd.com)
  • The development of insulin-dependent diabetes (IDDM) has been associated with recent enteroviral infection, particularly coxsackievirus B infection. (medscape.com)
  • In summary, the past history of infections by various enterovuses, which have been reported to induce an impairment of β-cells, and a recent infection by coxsackievirus A7 may be associated with the development of β-cell autoantibody-negative insulin-dependent diabetes in our patient. (diabetesjournals.org)
  • Measles is a highly contagious viral infection that is most common among children. (msdmanuals.com)
  • In most individuals, infection is asymptomatic or causes only mild symptoms. (wikipedia.org)
  • Infection may be asymptomatic or have symptoms ranging from mild upper respiratory symptoms to acute respiratory. (msdmanuals.com)
  • [ 4 ] Coxsackieviruses have been identified in the respiratory tract up to 3 weeks after initial infection and in feces up to 8 weeks after initial infection. (medscape.com)
  • Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)
  • This is a viral infection caused by human herpesvirus type 6 (HHV6). (bluefishmd.com)
  • however, in most cases the clinical have a viral infection as the most common cause of results are not sufficient to allow a specific etiologic the disease3,5,13. (bvsalud.org)
  • Coxsackievirus A7 has been reported to impair β-cells by inducing an increase of tumor necrosis factor-α in mice as well as coxsackievirus B4 ( 3 ). (diabetesjournals.org)
  • The administration of lipopoplysaccharide with coxsackievirus B3 is used to overcome a genetic barrier and induce autoimmune myocarditis in a strain of mice genetically resistant to infection with coxsackievirus alone. (the-rheumatologist.org)
  • Moreover, cardiomyocyte Hmgb1-deficient mice are more susceptible to cardiac dysfunction after infection. (bvsalud.org)
  • Coxsackieviruses share many characteristics with poliovirus. (medscape.com)
  • The CDC identified 19 individuals in the Dominican Republic who developed acute flaccid paralysis (AFP, the hallmark symptom of poliovirus infection as well as a syndrome unto itself) between July 12 and November 18, 2000. (harvoa.org)
  • The mystery deepens when we examine World Health Organization (WHO) statistics on AFP and poliovirus infection in the Dominican Republic for the last several years. (harvoa.org)
  • This fact raises new, disturbing questions, including whether there ever was an epidemic of poliovirus infection in the United States and Canada. (harvoa.org)
  • Since many of those cases showed all the hallmarks of a typical poliovirus infection fever, stiff neck and back, severe headache, muscle pain, sore throat and, in severe cases, paralysis and occurred in clusters, they were assumed to be caused by the easily-transmitted poliovirus. (harvoa.org)
  • [ 5 ] However, the infection frequently is eradicated before antibody production occurs. (medscape.com)
  • HHV-6, which can produce acute infection in CD4 + T lymphocytes, causes roseola infantum , a febrile illness that affects young children. (medscape.com)
  • Impetigo is a common infection of the top layers of skin caused by bacteria that are frequently carried as normal skin flora. (bluefishmd.com)
  • For 2 of the 3 years, coxsackievirus B1 was the predominant serotype. (medscape.com)
  • In others, infection produces short-lived (7-10 days) fever and painful blisters in the mouth (a condition known as herpangina), on the palms and fingers of the hand, or on the soles of the feet. (wikipedia.org)
  • Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
  • It is noteworthy that the initial clinical infections can present high morbidity and low presentations of viral meningitis and bacterial mortality rates. (bvsalud.org)
  • Bronchiolitis is an infection that causes the small breathing tubes of the lungs (bronchioles) to swell and become inflamed. (bluefishmd.com)
  • Systemic neonatal disease often is associated with group B coxsackieviruses. (medscape.com)
  • Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)
  • A urinary tract infection can also occur and, if left untreated, lead to further symptoms and complications. (electronicsencyclopedia.com)
  • So, acute flaccid myelitis (or AFM for short) is an uncommon but serious neurologic condition that most often seems to occur after a viral upper respiratory infection. (cdc.gov)
  • La proteína puede intervenir en la adhesión célula-célula, y es el principal sitio de unión de los ADENOVIRUS durante la infección. (bvsalud.org)
  • Coxsackievirus infections can cause a variety of illnesses, including heart disease. (healthresearchbc.ca)
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
  • 9 Recently, Rose proposed that, in addition to the known mechanisms by which infections elicit autoimmunity, an infectious adjuvant mechanism may play a role in immunopathogenesis. (the-rheumatologist.org)
  • Address reprint requests to Mailstop E-69, Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333. (cdc.gov)
  • and the Director, National Center for Infectious Diseases, regarding the practice of hospital infection control and strategies for surveillance, prevention, and control of nosocomial infections in US hospitals. (cdc.gov)
  • We also know that more than 90% of children with AFM had an upper respiratory infection consistent with a viral infection in the days before they developed AFM symptoms. (cdc.gov)
  • Strep throat is an infection of the throat caused by a bacteria named Group A Streptococcus. (bluefishmd.com)
  • To our knowledge, the association between coxsackievirus A7 infection and diabetes has not been discussed in regard to humans. (diabetesjournals.org)
  • Coxsackieviruses primarily are transmitted via the fecal-oral route and respiratory aerosols, although transmission via fomites also is possible. (medscape.com)
  • Coxsackie A virus leads to a number of diseases, however the most common signs and symptoms that appear with infection are fever and flu-like symptoms, mouth sores, and skin rashes. (wikipedia.org)
  • Outside of the symptoms, age is also taken into consideration as the most common age of infection is under five years of age. (wikipedia.org)
  • Innate, humoral and cell-mediated immunity all play a role in the body's response to enteroviral infection. (medscape.com)
  • Dr. Horwitz is examining how innate and adaptive immune responses following viral infection contribute to development of chronic heart disease. (healthresearchbc.ca)
  • Hand-foot-mouth disease is a common viral infection that most often begins in the throat. (medlineplus.gov)
  • Hand, foot, and mouth disease is the result of a viral infection. (medicalnewstoday.com)
  • The presenting complaints of the patients include lack of energy , delayed wound healing, visual blurring and fungal infections such as pruritis vulvae or balanitis [5]. (symptoma.mt)
  • Approximately 20% of patients present with a dramatic, overwhelming infection, often with neutropenia . (lu.se)
  • To assist hospitals in maintaining up-to-date isolation practices, the Centers for Disease Control and Prevention (CDC) and the Hospital Infection Control Practices Advisory Committee (1) (HICPAC) have revised the 'CDC Guideline for Isolation Precautions in Hospitals. (cdc.gov)
  • The guideline recommendations are based on the latest epidemiologic information on transmission of infection in hospitals. (cdc.gov)
  • A working draft of the guideline was reviewed by experts in infection control and published in the Federal Register for public comment. (cdc.gov)
  • HHV-2, also known as HSV-2, causes genital herpes and occasionally causes oral disease that is clinically similar to that of HHV-1 infection. (medscape.com)
  • There is no specific treatment for the infection other than symptom relief. (medlineplus.gov)
  • See Cutaneous Manifestations of HIV Disease and Cutaneous Manifestations of Hepatitis C for information on these viral infections. (medscape.com)
  • HHV-5, also known as cytomegalovirus (CMV), causes a primary infection of the salivary glands and other tissues, and it is believed to have a chronic form. (medscape.com)
  • Numerous group A coxsackieviruses are responsible for causing CNS disease similar to poliomyelitis. (medscape.com)
  • In rare cases, the disease is due to a bacterial infection. (electronicsencyclopedia.com)
  • Modification of the recommendations is encouraged if (1) the principles of epidemiology and disease transmission are maintained, and (2) precautions are included to interrupt spread of infection by all routes that are likely to be encountered in the hospital. (cdc.gov)
  • HHV infections are common in the oral cavity. (medscape.com)
  • HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)