Coxiella
Coxiella burnetii
Q Fever
Goats
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Endocarditis, Bacterial
Rickettsia
Zoonoses
Rickettsia rickettsii
Blotting, Southwestern
A method that is used to detect DNA-protein interactions. Proteins are separated by electrophoresis and blotted onto a nitrocellulose membrane similar to Western blotting (BLOTTING, WESTERN) but the proteins are identified when they bind labeled DNA PROBES (as with Southern blotting (BLOTTING, SOUTHERN)) instead of antibodies.
Seroepidemiologic Studies
Vacuoles
BRCA1 Protein
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
BRCA2 Protein
A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Recombination, Genetic
Cellular Apoptosis Susceptibility Protein
Thymidylate Synthase
Fluorodeoxyuridylate
Methylation
Formaldehyde
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Placenta
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages. (1/167)
Despite the antimicrobial mechanisms of vertebrate phagocytes, mycobacteria can survive within the phagosomes of these cells. These organisms use various strategies to evade destruction, including inhibition of acidification of the phagosome and inhibition of phagosome-lysosome fusion. In contrast to mycobacteria, Coxiella burnetii, the etiologic agent of Q fever, inhabits a spacious acidified intracellular vacuole which is prone to fusion with other vacuoles of the host cell, including phagosomes containing mycobacteria. The Coxiella-infected cell thus provides a unique model for investigating the survival of mycobacteria in an acidified phagosome-like compartment. In the present study, murine bone marrow-derived macrophages were infected with either Mycobacterium avium or Mycobacterium tuberculosis and then coinfected with C. burnetii. We observed that the majority of phagocytosed mycobacteria colocalized to the C. burnetii-containing vacuole, which maintained its acidic properties. In coinfected macrophages, the growth of M. avium was not impaired following fusion with the acidified vacuole. In contrast, the growth rate of M. tuberculosis was reduced in acidified vacuoles. These results suggest that although both species of mycobacteria inhibit phagosome-lysosome fusion, they may be differentially susceptible to the toxic effects of the acidic environment in the mature phagolysosome. (+info)Infectivity, transmission and 16S rRNA sequencing of a rickettsia, Coxiella cheraxi sp. nov., from the freshwater crayfish Cherax quadricarinatus. (2/167)
A rickettsia-like organism isolated from infected, farm-reared Cherax quadricarinatus was cultured in the yolk sac of developing chicken eggs, but could not be cultured in 3 continuous cell lines, bluegill fry (BF-2), fathead minnow (FHM), and Spodoptera frugiperda (Sf-9). The organism was confirmed by fulfilling Koch's postulates as the aetiological agent of mortalities amongst C. quadricarinatus. When C. quadricarinatus was inoculated with the organism, mortality was 100% at 28 degrees C and 80% at an ambient temperature of 24 degrees C. Horizontal transmission with food and via the waterborne route was demonstrated, but mortalities were lower at 30 and 10% respectively over a 4 wk period. The 16S rRNA sequence of 1325 base pairs of the Gram-negative, obligate intracellular organism was 95.6% homologous to Coxiella burnetii. Of 18 species compared to this rickettsia, the next most closely related bacterium was Legionella pneumophila at 86.7%. The suggested classification of this organism is Order Rickettsiales, family Rickettsiaceae, tribe Rickettsieae, within the genus Coxiella. We suggest it should be named Coxiella cheraxi sp. nov. (+info)Detection of long-term cellular immunity to Coxiella burneti as assayed by lymphocyte transformation. (3/167)
Delayed hypersensitivity to the antigens of Coxiella burneti, Nine Mile strain, was demonstrated in human subjects with various past histories of exposure to the organism by using lymphocyte transformation assays. Individuals with histories indicating exposure to C. burneti up to 8 years before the study demonstrated marked lymphocyte transformation in vitro to whole-cell antigens consisting of formalin-killed C. burneti phase I and phase II. These individuals also demonstrated a marked lymphocyte response to the trichloracetic acid-soluable phase I antigen. One individual who acquired Q fever during the study and one individual who received an experimental Q fever vaccine 4 years earlier were also evaluated by the lymphocyte transformation assay. It was also found that phase I trichloroacetic acid-soluble material was capable of acting as an antigen in the assay, whereas the phase II trichloroacetic acid-soluble material did not contain any antigenic material capable of causing lymphocyte transformation. The complete phase I trichloroacetic acid-soluble antigen, which was found to consist of protein and carbohydrate, was chemically fractionated into monospecific fractions. The fraction treated to eliminate carbohydrate was the only fraction found to elicit an in vitro response. (+info)Changes in buoyant density relationships of two cell types of Coxiella burneti phase I. (4/167)
Coxiella burneti phase I, purified from a formalin-inactivated yolk-sac vaccine, was separated into two bands of morphologically distinct cell types when subjected to sucrose gradient centrifugation. Recycling of the less dense, rod-shaped cells in unbuffered sucrose gradients (pH 5.5 to 6.0) resulted in the formation of bands having the location and appearance of the original two bands. Recycling of the denser band of larger ovoid-shaped cells yielded a single band, suggesting that the larger cell type arose from the smaller cell. In contrast to vaccine-derived rickettsiae, live, cell culture-propagated phase I organisms formed a single band in unbuffered sucrose gradients, at the same density as the upper band of the vaccine preparation. Centrifugation of cell culture-derived rickettsiae for 26 to 48 h in sucrose gradients of pH 5.5 resulted in the formation of a second band, at the same density as the lower band of the vaccine preparation. This did not occur in gradients of pH 7.0. Treatment of cell culture-propagated rickettsiae with formalin or germicidal ultraviolet radiation induced a total shift of the less dense cell population to a zone of higher density when centrifuged isopycnically in CsC1 gradients. This density change did not occur in sucrose gradients, suggesting a difference in the effect of these treatments on the permeability of the cell membrane to sucrose and CsC1. (+info)Glomerulonephritis associated with Coxiella burnetii endocarditis. (5/167)
A patient with endocarditis associated with chronic Coxiella burnetii infection is described in whom glomerulonephritis developed with granular deposits containing immunoglobulins and complement in the glomeruli. The serum was notable for the variety of circulating antibodies detected, which included antibodies directed against native DNA. (+info)Studies on the physiology of Rickettsiae. IV. Folic acids of Coxiella burnetii. (6/167)
Mattheis, Martha S. (University of Kansas, Lawrence), M. Silverman, and D. Paretsky. Studies on the physiology of rickettsiae. IV. Folic acids of Coxiella burnetii. J. Bacteriol. 85:37-41. 1963.-Yolk, yolk sac, and embryo tissues of uninfected eggs, and those infected with Coxiella burnetii, were analyzed for folic acid derivatives by employing diethylaminoethyl (DEAE)-cellulose column chromatography. Infected tissues contained quantitatively less folate, but the elution profiles of both infected and uninfected tissues were identical. Purified C. burnetii contained some types of folate apparently unique to these rickettsiae, and not found in infected tissue. The major folate fraction of C. burnetii was partially characterized by (i) elution position from DEAE columns; (ii) treatment with conjugase; (iii) growth response by Lactobacillus casei, Streptococcus faecalis R, and Pediococcus cerevisiae; and (iv) response to oxidation, reduction, and formylation. (+info)CONVERSION OF THE PHASE I ANTIGEN OF COXIELLA BURNETII TO HAPTEN BY PHENOL TREATMENT. (7/167)
Anacker, R. L. (Rocky Mountain Laboratory, Hamilton, Mont.), W. T. Haskins, D. B. Lackman, E. Ribi, and E. G. Pickens. Conversion of the phase I antigen of Coxiella burnetii to hapten by phenol treatment. J. Bacteriol. 85:1165-1170. 1963.-Trichloroacetic acid extracts of Coxiella burnetii are converted to hapten by treatment with phenol. Such extracts react, like the original trichloroacetic acid extract, at high dilution in the complement-fixation test and produce zones of precipitate with specific antibody in gel diffusion tests; but, unlike the parent extract, injection of the phenol-treated extract neither induces resistance to challenge in guinea pigs nor antibody formation in guinea pigs, rabbits, or mice. This loss of antigenicity is correlated with removal of protein from the original product. (+info)STUDIES ON THE PHYSIOLOGY OF RICKETTSIAE. V. METABOLISM OF CARBAMYL PHOSPHATE BY COXIELLA BURNETII. (8/167)
Mallavia, L. (University of Kansas, Lawrence) and D. Paretsky. Studies on the physiology of rickettsiae. V. Metabolism of carbamyl phosphate by Coxiella burnetii. J. Bacteriol. 86:232-238. 1963.-Preparations of disrupted Coxiella burnetii catalyze synthesis of citrulline from ornithine and carbamyl phosphate at an optimal pH of 7.0 to 7.5. Rickettsial synthesis of the pyrimidine precursor, ureidosuccinate, is demonstrated and confirmed by isolating C(14)-labeled ureidosuccinate from reaction mixtures of carbamyl phosphate and labeled aspartate. The data suggest a further rickettsial synthesis of orotate and imply rickettsial competence for host-independent pyrimidine synthesis. (+info)
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Prevalence Study of Coxiella burnetii in Aborted Ovine and Caprine Fetuses by Evaluation of Nested and Real-Time PCR Assays |...
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Electron microscopy of Coxiella burnetii in tissue culture. Induction of cell types as products of developmental cycle. - UQ...
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Phagosome
They either reproduce inside of the phagolysosome (e.g. Coxiella spp.) or escape into the cytoplasm before the phagosome fuses ... "Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii". Proceedings of the National Academy of ...
Q fever
Coxiella burnetii)" [Is A29, B12 vasculitis caused by the Q fever agent? (Coxiella burnetii)]. Journal Français d'Ophtalmologie ... Coxiella burnetii - named for Cox and Burnet - is no longer regarded as closely related to the Rickettsiae, but as similar to ... Q fever or query fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and other ... Camuset, P; Remmy, D (2008). "Q Fever (Coxiella burnetii) Eradication in a Dairy Herd by Using Vaccination with a Phase 1 ...
Gamasoidosis
Coxiella burnetii, Bartonella spp., Borrelia burgdorferi, Venezuelan equine encephalitis virus, Eastern equine encephalitis ...
Atypical pneumonia
Coxiella burnetii Causes Q fever. Francisella tularensis Causes tularemia. Legionella pneumophila Causes a severe form of ...
Pneumonia
Exposure to birds is associated with Chlamydia psittaci; farm animals with Coxiella burnetti; aspiration of stomach contents ...
Coccobacillus
Coxiella burnetii is also a coccobacillus. Bacteria from the genus Brucella are medically important coccobacilli that cause ...
Bacterial cellular morphologies
Coxiella burnetti is also a coccobacillus. Spiral bacteria are another major bacterial cell morphology. Spiral bacteria can be ...
Endospore
Coxiella (i.e. Coxiella burnetii). *Dendrosporobacter. *Desulfotomaculum. *Desulfosporomusa. *Desulfosporosinus. * ...
Lake Galilee (Queensland)
Coxiella sp.) Pastoral settlement began on the eastern side of Lake Galilee in 1877, when Charles Bowly acquired the Oakley run ...
Amblyomma gervaisi
It is a potential vector for Coxiella burnetii. "Species Details : Amblyomma gervaisi Lucas, 1847". Catalogue of Life. ...
Coxiellaceae
Coxiella burnetii is a species in this order. Another is Rickettsiella melolonthae. Legionellales "List of genera included in ...
Johnston Atoll
Coxiella burnetii (Agent OU), causative agent of Q fever; and Bacillus globigii (Agent BG). During Project SHAD, Bacillus ...
Legionella clemsonensis
Legionella has a correlation with another genus called Coxiella. Both cause lung infection that can eventually lead to ... "Specificity of Legionella pneumophila and Coxiella burnetii vacuoles and versatility of Legionella pneumophila revealed by ...
Haemaphysalis leporispalustris
Also, H. leporispalustris transmits Coxiella burnetii and Francisella tularensis. Strains of Anaplasma bovis have also been ...
Rickettsia akari
21: Rickettsia, Orientia, Ehrlichia, Anaplasma, Coxiella and Bartonella". Microbiology and Immunology On-line. University of ...
Bandicoot
... s may serve as a primary reservoir for Coxiella burnetii. Infection is transmitted among them by ticks. These are then ...
Intracellular parasite
However, in 2009 scientists reported a technique allowing the Q-fever pathogen Coxiella burnetii to grow in an axenic culture ... Rickettsia Coxiella Certain species of Mycobacterium such as Mycobacterium leprae Certain protozoa, including: Apicomplexans ( ... "Host cell-free growth of the Q fever bacterium Coxiella burnetii". Proceedings of the National Academy of Sciences USA. 106 (11 ...
Valérie Belin
Wachter, R. F.; Briggs, G. P.; Pedersen, C. E. (November 1975). "Precipitation of phase I antigen of Coxiella burnetii by ...
Pomatiopsidae
Terrestrial taxa occur only on the Japanese Archipelago located in East Asia (Blanfordia). Tomichia and Coxiella include ... Williams, W. D.; Mellor, M. W. (1991). "Ecology of Coxiella (Mollusca, Gastropoda, Prosobranchia), a snail endemic to ... 1861 Coxiella E. A. Smith, 1894 Floridiscrobs Pilsbry and McGinty, 1949 Fukuia Abbott & Hunter, 1949 Hemibia Heude, 1890 ( ...
Bremetennacum
Wachter, R. F.; Briggs, G. P.; Pedersen, C. E. (1975). "Precipitation of phase I antigen of Coxiella burnetii by sodium sulfite ...
List of sequenced bacterial genomes
2003). "Complete genome sequence of the Q-fever pathogen Coxiella burnetii". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5455-60. ...
Tick
Duron O (September 2015). "The IS1111 insertion sequence used for detection of Coxiella burnetii is widespread in Coxiella-like ... Since Coxiella and Francisella endosymbionts are closely related to pathogens, there is a substantial risk of misidentification ... Although Coxiella and Francisella endosymbionts are distantly related bacteria, they have converged towards an analogous B ... December 2017). "A Coxiella mutualist symbiont is essential to the development of Rhipicephalus microplus". Scientific Reports ...
Axenic
2009). "Host cell-free growth of the Q fever bacterium Coxiella burnetii". PNAS. 106 (11): 4430-4434. Bibcode:2009PNAS.. ... Coxiella burnetii. Asepsis Gnotobiotic animal Germ-free animal Sterilization (microbiology) Thain, M.; Hickman, M. (1994). ...
Pasteurization
Complete inactivation of Coxiella burnetii (which was thought at the time to cause Q fever by oral ingestion of infected milk) ... Enright, J.B.; Sadler, W.W.; Thomas, R.C. (1957). "Thermal inactivation of Coxiella burnetii and its relation to pasteurization ... Cerf, O.; Condron, R. (2006). "Coxiella burnetii and milk pasteurization: an early application of the precautionary principle ... of Hygienic Practice for Milk notes that milk pasteurization is designed to achieve at least a 5 log10 reduction of Coxiella ...
Haemaphysalis hystricis
It is a potential vector of Kyasanur Forest disease virus, Coxiella sp., Ehrlichia sp., and Rickettsia japonica. In 2007, an ...
Phagolysosome
Coxiella burnetii, the causative agent of Q fever, thrives and replicates in the acidic phagolysosomes of its host cell. The ... Maurin, M.; Benoliel, A. M.; Bongrand, P.; Raoult, D. (1992-12-01). "Phagolysosomes of Coxiella burnetii-infected cell lines ... Howe, Dale; Mallavia, Louis P. (2016-11-19). "Coxiella burnetii Exhibits Morphological Change and Delays Phagolysosomal Fusion ...
Phagosome
They either reproduce inside of the phagolysosome (e.g. Coxiella spp.)[1] or escape into the cytoplasm before the phagosome ... "Coxiella burnetii". Proc Natl Acad Sci U S A. 78 (5): 3240-3244. doi:10.1073/pnas.78.5.3240. PMC 319537. PMID 6942430.. .mw- ...
Legionellales
They comprise two families, typified by Legionella and Coxiella, both of which include notable pathogens. For example, Q fever ... is caused by Coxiella burnetii and Legionella pneumophila causes Legionnaires' disease and Pontiac fever. George M. Garrity: ...
Ixodes holocyclus
... is also commonly mentioned as a potential vector of Q fever (Coxiella burnetii). The ornate kangaroo tick ( ...
Brown rat
1995). "Q fever (Coxiella burnetii) reservoir in wild brown rat (Rattus norvegicus) populations in the UK". Parasitology. 110: ... In the United Kingdom, brown rats are an important reservoir for Coxiella burnetii, the bacterium that causes Q fever, with ...
Coxiella - Wikipedia
Coxiella burnetii - Wikipedia
Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. The genus Coxiella is ... Coxiella, and then in 1948 to its own genus of that name, proposed by Cornelius B. Philip, another RML researcher. Coxiella was ... Coxiella burnetii small RNAs (CbSRs 1, 11, 12, and 14) are encoded within intergenic region (IGR). CbSRs 2, 3, 4 and 9 are ... Sankaran N (2000). "Coxiella burnetii". Microbes and people : an A-Z of microorganisms in our lives. Phoenix, Arizona: The Oryx ...
The Coxiella burnetii parasitophorous vacuole. - PubMed - NCBI
Coxiella burnetii - BfR
Coxiella burnetii. Q Fever. The pathogens occur all over the world and can result in a Q fever infection in humans. The ... Coxiella brunetii has a broad host range but is detected primarily in sheep, goats, cattle and wild ruminants. In natural herds ... Coxiella (C.) burnetii is a pleomorphic (rod-like, coccoid lanceolate) gram-variable bacterium from the family of ...
How to Prevent Q Fever (Coxiella Burnetii Infection): 11 Steps
... caused by infection of the bacteria Coxiella burnetii) is an animal-to-human infection. The illness brings severe flu-like ... Preventing Coxiella burnetii Infection * {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/1\/10\/Prevent-Q-Fever-% ... Know if you are at risk. Coxiella burnetii is excreted in the milk, urine, and feces of infected animals. Cows, sheep, and ... Based on where your facility is located, you may or may not be able to legally use the Coxiella burnetii vaccine.[10] X ...
Animal Models of Q Fever (Coxiella burnetii): Ingenta Connect
Fusogenicity of the Coxiella burnetii parasitophorous vacuole. - PubMed - NCBI
Characterization of Coxiella burnetii outbreak strains - WUR
Characterization of Coxiella burnetii outbreak strains. Status: Completed Start project:. Sep 1, 2011. End project:. Sep 1, ... Characterization of Coxiella burnetii outbreak strains Q fever is a worldwide zoonotic infectious disease caused by the ... bacterium Coxiella burnetii. During 2007-2010, the largest Dutch Q fever outbreak was reported, reporting more than 4000 human ...
Developmental biology of Coxiella burnettii
Coxiella burnetii, has a remarkable ability to persist in the extracellular environment. It replicates only when phagocytosed ... Developmental biology of Coxiella burnettii Trends Microbiol. 1999 Apr;7(4):149-54. doi: 10.1016/s0966-842x(99)01475-4. ... The obligate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to persist in the ...
NIOSHTIC-2 Publications Search - 20023504 - Prevalence of Coxiella burnetii infections among North Dakota sheep producers.
Coxiella burnetii infections (Q fever)
View source for Coxiella - microbewiki
Coxiella is an acidophilic bacteria, requiring a pH of 4.5-5 to grow. Morpholgically, Coxiella resembles Rickettsia. ... Coxiella is a genus best known for the species Coxiella burnetii, the causative agent of Q fever. Q fever affects ... Coxiella, and Bartonella."]]] Coxiella are Gram-negative. Cell walls are composed of peptidoglycan. There are two cell ... Coxiella reproduce by binary fission. They are durable organisms, capable of reproduction in the presence of chemicals such ...
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Coxiella Burnetii (Q Fever) Antibodies - Serum (Surplus) Data Documentation, Codebook, and Frequencies
KEGG PATHWAY: Pentose phosphate pathway - Coxiella burnetii CbuK Q154
KEGG PATHWAY: Homologous recombination - Coxiella burnetii Dugway 5J108-111
RCSB PDB - 3TRH: Structure of a phosphoribosylaminoimidazole carboxylase catalytic subunit (purE) from Coxiella burnetii
Coxiella burnetii. Mutation(s): 0 Gene Names: CBU_2002, purE. EC: 4.1.1.21 (PDB Primary Data), 5.4.99.18 (UniProt). ... Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as ... Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as ... Find proteins for Q83AA3 (Coxiella burnetii (strain RSA 493 / Nine Mile phase I)) ...
thyA - Thymidylate synthase - Coxiella burnetii (strain Dugway 5J108-111) - thyA gene & protein
Coxiella burnetii (strain RSA 331 / Henzerling II). Coxiella burnetii (strain RSA 493 / Nine Mile phase I). Coxiella burnetii. ... Coxiella burnetii (strain RSA 331 / Henzerling II). Coxiella burnetii (strain RSA 493 / Nine Mile phase I). Coxiella burnetii. ... cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella ... sp,A9KF61,TYSY_COXBN Thymidylate synthase OS=Coxiella burnetii (strain Dugway 5J108-111) GN=thyA PE=3 SV=1 ...
Coxiella burnetii | Infection and Immunity
Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates Coxiella burnetii, the ... Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages Coxiella burnetii is an obligate intracellular ... Coxiella burnetii Requires Host Eukaryotic Initiation Factor 2α Activity for Efficient Intracellular Replication Coxiella ... Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella ...
RCSB PDB - 3TQN: Structure of the transcriptional regulator of the GntR family, from Coxiella burnetii.
Coxiella burnetii. Mutation(s): 0 Gene Names: CBU_0775. Find proteins for Q83DG1 (Coxiella burnetii (strain RSA 493 / Nine Mile ... Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as ... Coxiella burnetii is a highly infectious bacterium and potential agent of bioterrorism. However, it has not been studied as ... Structural genomics for drug design against the pathogen Coxiella burnetii.. Franklin, M.C., Cheung, J., Rudolph, M.J., ...
Additional Confirmed Cases of Q fever (Coxiella burnetii) in Colorado | Department of Agriculture - Animal Health
ASMscience | Coxiella*
This chapter talks about Coxiella burnetii, Q fever and typing systems. Q fever can be latent and recrudesce during periods of ... Coxiella burnetii antigens for detection of Q fever antibodies by ELISA in human sera. Acta Virol. 31:254-259.. ... Coxiella * , Page 1 of 2 , Previous page , Next page , /docserver/preview/fulltext/10.1128/9781555816728/9781555814632_Chap63-1 ... Coxiella * , p 1027-1034. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical ...
Frontiers | Horizontally Acquired Biosynthesis Genes Boost Coxiella burnetii's Physiology | Cellular and Infection Microbiology
... burnetii are different from that of Coxiella-like bacteria found in ticks. Horizontally acquired genes that allow C. burnetii ... burnetii are different from that of Coxiella-like bacteria found in ticks. Horizontally acquired genes that allow C. burnetii ... very little is known about genes that facilitate Coxiellas intracellular growth. Recent studies indicate that C. burnetii ... very little is known about genes that facilitate Coxiellas intracellular growth. Recent studies indicate that C. burnetii ...
PLOS ONE: Q Fever in Pregnant Goats: Pathogenesis and Excretion of Coxiella burnetii
gltX1 - Glutamate--tRNA ligase 1 - Coxiella burnetii (strain CbuG Q212) - gltX1 gene & protein
Coxiella burnetii (strain Dugway 5J108-111). Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154)). Coxiella ... Coxiella burnetii. Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154)). Coxiella burnetii (strain RSA 331 / ... Coxiella burnetii (strain RSA 493 / Nine Mile phase I). Coxiella burnetii. 465. UniRef90_A9KBJ3. Cluster: Glutamate--tRNA ... cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella ...
Coxiella burnetti bacteria, TEM - Stock Image C021/7428 - Science Photo Library
Coxiella burnetti bacteria, coloured transmission electron micrograph (TEM). This bacterium affects humans and other animals ... Keywords: animal vectors, bacteria, bacterial, bacteriology, bacterium, biological, biology, coloured, coxiella burnetii, ... Caption: Coxiella burnetti bacteria, coloured transmission electron micrograph (TEM). This bacterium affects humans and other ... coxiella burnetti, false-coloured, febrile illness, infected, infection, livestock transmission, micro-organism, micro- ...
Coxiella - Semantic Scholar
Highly prevalent Coxiella sp. bacterium in the tick vector Amblyomma americanum.. *Algimantas Jasinskas, Jianmin Zhong, Alan G ... Coxiella. Known as: Burnetia A genus of gram-negative, rod-shaped bacteria that is widely distributed in TICKS and various ... Legionella and Coxiella are intracellular pathogens that use the virulence-related Icm/Dot type-IVB secretion system to… (More) ... Coxiella burnetii, which causes Q fever, is a highly infectious agent that is widespread among livestock around the world… ( ...
Seroprevalence and risk factors of Coxiella burnetii infection in cattle in northeast Algeria | SpringerLink
Menadi, S.E., Mura, A., Santucciu, C. et al. Seroprevalence and risk factors of Coxiella burnetii infection in cattle in ... Seroprevalence and risk factors of Coxiella burnetii infection in cattle in northeast Algeria. *Salah Eddine Menadi. ORCID: ... Paper: Prevalence of Coxiella burnetii infection in Dutch dairy herds based on testing bulk tank milk and individual samples by ... Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds. ...
Small Things Considered: The Spell of Coxiella
... achieving the growth of Coxiella burnetii out-side its host cells in laboratory media (see Coxiella Escapes from Cell!). The ... Figure 2 Coxiella burnetii binds to macrophages through αvβ3 integrin, which triggers phago-cy-to-sis through an actin- ... The nascent Coxiella-containing vacuole (CCV) acidifies to pH ~5.4, which is characteristic of nor-mal phagosomal development. ... Within its vacuoles (known as Coxiella-Containing Vacuoles, or CCVs), the organisms proliferate to the extent that a CCV can ...
FeverInfectionRickettsiaBacteriaAbstractPathogenVacuoleAntibodiesBurnettiPrevalenceInfectionsVirulenceGenusOrganismMacrophagesPathogenesisCharacterizationGoatsType IVB secretionTicksGeneSpeciesAntibodyBurnetii seroprevalenceTransmission electron mStrictly intracellular bacteriumDairyGenomePathwaysSymbiontDetectionRisk factorsRuminantsGenotypesSerumGeneticReplication
Fever68
- Coxiella is a taxonomic homonym: Coxiella (bacterium), genus of bacteria in the family Coxiellaceae Coxiella burnetii, the causative agent of Q fever Coxiella (gastropod), genus of snails from saline lakes in the family Pomatiopsidae This disambiguation page lists articles about distinct genera with the same name. (wikipedia.org)
- Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. (wikipedia.org)
- Coxiella -like bacteria have been associated with infection cal signs (fever, skin eschar, local lymph node enlargement) in birds ( 4 , 5 ). (cdc.gov)
- Q fever (caused by infection of the bacteria Coxiella burnetii ) is an animal-to-human infection. (wikihow.com)
- Q fever, caused by the pathogen Coxiella burnetii , is an acute disease that can progress to become a serious chronic illness. (ingentaconnect.com)
- Q fever is a worldwide zoonotic infectious disease caused by the bacterium Coxiella burnetii . (wur.nl)
- The obligate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to persist in the extracellular environment. (nih.gov)
- Description and Significance== ''Coxiella'' is a genus best known for the species ''Coxiella burnetii'', the causative agent of Q fever. (kenyon.edu)
- Coxiella burnetii'', the most famous species of this genus, causes human Q fever (short for query fever). (kenyon.edu)
- Q fever is a zoonotic disease with acute and chronic stages caused by the rickettsia-like organism Coxiella burnetii. (cdc.gov)
- Coxiella burnetii is the causative agent of human Q fever, eliciting symptoms that range from acute fever and fatigue to chronic fatal endocarditis. (asm.org)
- The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious chronic infection. (asm.org)
- Coxiella burnetii , the etiological agent of Q fever, is a Gram-negative bacterium transmitted to humans by inhalation of contaminated aerosols. (asm.org)
- Coxiella burnetii is an obligate intracellular Gram-negative bacterium which causes human Q fever. (asm.org)
- Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. (asm.org)
- This chapter talks about Coxiella burnetii , Q fever and typing systems. (asmscience.org)
- Coxiella burnetii , the etiologic agent of acute Q fever and chronic endocarditis, has a unique biphasic life cycle, which includes a metabolically active intracellular form that occupies a large lysosome-derived acidic vacuole. (frontiersin.org)
- Coxiella burnetii is the etiological agent of acute Q fever and a chronic disease commonly manifested as endocarditis ( Maurin and Raoult, 1999 ). (frontiersin.org)
- Coxiella burnetii (medical condition): A disease caused by Coxiella burnetti which causes fever. (rightdiagnosis.com)
- Q fever is a zoonotic disease caused by Coxiella burnetii, a species of bacteria that is distributed globally. (rightdiagnosis.com)
- Coxiella burnetii , the causative agent of Q fever, is a small obligately intracellular bacterium, which is associated with animals. (mayomedicallaboratories.com)
- 4. Fenollar F, Fournier PE, Raoult D: Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection. (mayomedicallaboratories.com)
- Here, we describe a nonpreviously reported antibacterial mechanism used by MCs against Coxiella burnetii , the agent of Q fever. (asm.org)
- The intervening sequence (IVS) of Coxiella burnetii , the agent of Q fever, is a 428-nt selfish genetic element located in helix 45 of the precursor 23S rRNA. (frontiersin.org)
- van der Hoek W , Hogema B M , Dijkstra F , Rietveld A , Wijkmans C J , Schneeberger P M , Zaaijer H L . Relation between Q fever notifications and Coxiella burnetii infections during the 2009 outbreak in the Netherlands. (eurosurveillance.org)
- The present study was carried out immediately after the peak of the 2009 outbreak to estimate the ratio between Coxiella burnetii infections and Q fever notifications. (eurosurveillance.org)
- Q fever is a disease caused by a germ called Coxiella Burnetti. (thetraveldoctor.com.au)
- INTRODUCTION: Coxiella burnetii, the causative agent of Q fever, may cause endocarditis and vascular infections that result in severe morbidity and mortality. (biomedsearch.com)
- Coxiella burnetii , the causative organism of Q fever, is increasingly reported to be associated with infections of abdominal aortic aneurysms and vascular grafts. (biomedsearch.com)
- Coxiella burnetii is a bacterium that causes Q fever, a zoonosis that affects large numbers of both humans and animals. (rivm.nl)
- The Q fever agent Coxiella burnetii is a Gram-negative bacterium that invades macrophages and replicates inside a specialized lysosomal vacuole. (asm.org)
- Coxiella burnetii is a Gram-negative intracellular pathogen that causes human Q fever, a zoonotic disease that is commonly transmitted to humans through inhalation of by-products generated by infected domestic livestock ( 1 ). (asm.org)
- Monocytic THP-1 cells were infected with Coxiella burnetii , the etiological agent of Q fever, and then treated with IFN-γ. (jimmunol.org)
- Coxiella burnetii is the causative agent of Q fever Footnote 4 . (canada.ca)
- Q fever and Coxiella burnetii: a model for host-parasite interactions. (asm.org)
- The obligate intracellular bacterium Coxiella burnetii , the agent of Q fever in humans and of coxiellosis in other animals, survives and replicates within large, acidified, phagolysosome-like vacuoles known to fuse homo- and heterotypically with other vesicles. (asm.org)
- Coxiella burnetii is the causative agent of human Q fever, a zoonotic disease that can cause a debilitating, flu‐like illness in acute cases, or a life‐threatening endocarditis in chronic patients. (iupui.edu)
- Coxiella burnetii is a Gram-negative, obligate intracellular bacterium and the causative agent of Q fever, a widespread zoonotic infectious disease ( 2 , 11 ). (asm.org)
- Dairy cattle are a primary reservoir of Coxiella burnetii, which causes Q fever. (cdc.gov)
- Coxiella burnetii is an intracellular bacterium that causes the disease Q fever, which presents in both acute and chronic forms in humans ( 1 ). (asm.org)
- Goats are known reservoirs of Coxiella burnetii, the etiologic agent of Q fever. (biomedcentral.com)
- Coxiella burnetii , the causative agent of Q fever, is a zoonotic pathogen associated with sylvatic or domestic transmission cycles, with rodents being suspected to link the two transmission cycles. (biomedcentral.com)
- Q fever is a ubiquitous zoonosis caused by Coxiella burnetii , an obligate intracellular rickettsial organism that caused abortion and stillbirth in ruminants. (thescipub.com)
- Coxiella burnetii is a zoonotic pathogen that resides in wild and domesticated animals across the globe and causes a febrile illness, Q fever, in humans. (biomedcentral.com)
- Coxiella burnetii is an obligate intracellular pathogen and the etiological agent of Q-fever, a zoonotic disease of humans which has been reported from almost every country worldwide [ 1 ]. (biomedcentral.com)
- for example, Coxiella burnetti , responsible for Q-fever, can be excreted in the milk of aborting goats for up to 52 days (91). (thefreedictionary.com)
- For example, a syndrome with similarities to ME/CFS occurs in approximately 10% of patients with a variety of viral and nonviral pathogens, such as Epstein-Barr Virus, Ross River Virus, Coxiella burnetti (Q fever), or Giardia (12). (thefreedictionary.com)
- Coxiella burnetti infection, also known as Q fever, was another communicable disease that should have received greater predeployment consideration. (thefreedictionary.com)
- Coxiella burnetti Infection (Q fever): A bacterial disease occasionally associated with cats. (thefreedictionary.com)
- Coxiella burnetii, a gram-negative obligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterrorism. (nih.gov)
- Q-fever is an underreported disease caused by the bacterium Coxiella burnetii , which is highly infectious and has the ability to disperse great distances. (microbiologyresearch.org)
- 1. Seroprevalence and risk factors of Coxiella burnetii (Q fever) infection in humans in Bura irrigation scheme, Tana River County, Kenya Mwololo D.K.,1, 3 Kitala P.M.,1 Wanyoike S.K.2 and Bett B.3 1. (slideshare.net)
- 2. INTRODUCTION Coxiellosis (Q fever) is a zoonotic disease caused by the bacterium Coxiella burnetii (CB) (Brom et al. (slideshare.net)
- Coxiella burnetii, the etiologic agent of Q fever, is a Gram-negative obligate intracellular bacterium. (gob.ar)
- Infections from Coxiella burnetii , resulting in what is known as Q fever, are relatively rare and difficult to diagnose. (scientificscholar.in)
- Coxiella burnetii is a ubiquitous zoonotic bacterial pathogen and the cause of human acute Q fever, a disabling influenza-like illness. (grantome.com)
- BACKGROUND: Prior to the 2007-2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. (uu.nl)
- Coxiella burnetii is an intracellular bacterial pathogen that causes human Q fever, an acute flu-like illness that can progress to chronic endocarditis and liver and bone infections. (elsevier.com)
- purpose: Cardiac valves that were resected from patients with Q fever endocarditis were examined by immunohistologic methods to correlate the presence of Coxiella burnetii in the valves with the histopathologic, serologic, microbiologic, and clinical findings. (elsevier.com)
- Brouqui, P, Dumler, JS & Raoult, D 1994, ' Immunohistologic demonstration of coxiella burnetii in the valves of patients with Q fever endocarditis ', The American journal of medicine , vol. 97, no. 5, pp. 451-458. (elsevier.com)
- Coxiella burnetii (C. burnetii) is an intracellular gram-negative bacterium, which is the causative agent of the widespread zoonotic disease Q fever. (edu.au)
- Coxiella burnetii is the etiologic agent of human Q fever and targets alveolar phagocytic cells in vivo wherein the pathogen generates a phagolysosome-like parasitophorous vacuole (PV) for replication. (sparrho.com)
- Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii . (biomedcentral.com)
- An easy-to-handle microarray assay based on the cost-effective ArrayTube™ platform has been designed for the rapid and unequivocal identification of Coxiella burnetii, the causative agent of Q fever. (biomedcentral.com)
- Coxiella burnetii is a human pathogen that causes the serious zoonotic disease Q fever. (cdc.gov)
- From 2007 through 2010, over 4,000 human cases were notified and approximately a twelve-fold higher number was probably infected by Coxiella burnetii, the causative agent of Q fever. (uu.nl)
- Modelled airborne Coxiella burnetii concentrations were a better predictor for Q fever incidence than distance alone. (uu.nl)
- 4) Several variables related to transmission through re-aerosolisation from a contaminated environment - such as the sensitivity of soils to wind erosion - increased the correlation to reported Q fever incidence rates and thus probably influenced Coxiella burnetii exposure. (uu.nl)
Infection15
- To estimate the prevalence of Coxiella burnetii infection and identify associated risk factors, we conducted a study covering the whole state. (cdc.gov)
- Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole membrane into the host cytoplasm, where they. (asm.org)
- Evaluation of infected tissue, blood, or serum using PCR may be a useful tool for diagnosing some cases of Coxiella burnetii infection. (mayomedicallaboratories.com)
- A positive test is diagnostic of Coxiella burnetii infection. (mayomedicallaboratories.com)
- Coxiella burnetii prosthetic joint infection-case report and assay for detection. (mayomedicallaboratories.com)
- The purpose of this study was to determine the seroprevalence and risk factors of Coxiella burnetii infection in veterinary-associated populations in southern Taiwan. (wiley.com)
- This study showed a new and effective antimicrobial mechanism of MCs against Coxiella burnetii , an intracellular bacterium whose infection during pregnancy is associated with abortion, preterm labor, and stillbirth. (asm.org)
- Since asymptomatic Coxiella burnetii infection has been associated with maternal and obstetric complications, evidence about the effectiveness of routine screening during pregnancy in outbreak areas is needed. (eurosurveillance.org)
- Viability of the Coxiella in milk was shown by a ≥ 0.5 log genome equivalent (ge)/ml increase in the quantity of IS111a gene from the baseline post-infection (day 0) level after 9-11 d propagation. (unboundmedicine.com)
- Coxiella in skim, 2%, and whole milk, and half and half successfully infected Vero cells and increased in number by at least 2 logs using a 48-h infection period followed by 9-d propagation time. (unboundmedicine.com)
- Upon host cell infection, the obligate intracellular bacterium Coxiella burnetii resides and multiplies within the C oxiella -Containing Vacuole (CCV). (prolekare.cz)
- Using microinjection of fluorescence-coupled dextrans, a FRET assay, and galectins distribution, we demonstrate that Coxiella infection actually result in transient phagosomal/CRV membrane damage in a Dot/Icm-dependent manner. (gob.ar)
- Pathogenesis of Coxiella burnetii Human infection usually follows inhalation of aerosols containing C. burnetii. (microbenotes.com)
- Lundy P, Arnold P, Hance K. Coxiella burnetii infection of the spine requiring neurosurgical intervention. (scientificscholar.in)
- Thirteen strains within the six major genetic groups of Coxiella were evaluated for pathogenicity in a guinea pig model of infection. (grantome.com)
Rickettsia5
- The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and physiological differences. (wikipedia.org)
- As it became clear that the species differed significantly from other Rickettsia, it was first elevated to a subgenus named after Cox, Coxiella, and then in 1948 to its own genus of that name, proposed by Cornelius B. Philip, another RML researcher. (wikipedia.org)
- Infectivity, transmission and I6S rRNA sequencing of a rickettsia, Coxiella cheraxi sp nov. (thefreedictionary.com)
- Borrelia burgdorferi sensu lato, Coxiella burnetii, and Rickettsia spp. (google.com)
- Coxiella burnetii, and Rickettsia spp. (google.com)
Bacteria16
- To explore pathogenicity to humans, we used and if a removed tick was positive for Coxiella -like bacte- molecular techniques targeting Coxiella- like bacteria to ria according to qPCR but no skin biopsy was sampled or retrospectively analyze skin biopsy samples and ticks col- when serologic results were positive. (cdc.gov)
- Ticks were identified by matrix-assisted la- for the Coxiella -like bacteria associated with R. sanguin- ser desorption/ionization time-of-flight mass spectrom- eus , R. turanicus , and H. pusillus ticks to be Candidatus C. etry (Bruker Daltonics, Billerica, USA) ( 6 ). (cdc.gov)
- and Coxiella burnetii by quanti- tients were infected with Coxiella -like bacteria only: 11 tative PCR (qPCR) ( 2 , 7 ). (cdc.gov)
- On the basis of the aligned rrs (55%) Dermacentor marginatus , 7 (35%) R. sanguineus , gene sequences of Coxiella -like bacteria, we developed 1 (5%) R. bursa , and 1 (5%) Ixodes ricinus ticks. (cdc.gov)
- Coxiella- a specific qPCR to detect the DNA of all Coxiella spe- like bacteria were found significantly less commonly in I. cies and degenerated primers aimed to amplify a 659-bps ricinus ticks (p = 0.002, relative risk = 0.5). (cdc.gov)
- Coxiella ''is an acidophilic bacteria, requiring a pH of 4.5-5 to grow. (kenyon.edu)
- Coxiella'' bacteria are obligate organisms, meaning they rely on their hosts for nutritional and environmental support. (kenyon.edu)
- Monkey cell infected containing roughly twenty ''Coxiella burnetii'' bacteria. (kenyon.edu)
- Recent studies indicate that C. burnetii evolved from a tick-associated ancestor and that the metabolic capabilities of C. burnetii are different from that of Coxiella -like bacteria found in ticks. (frontiersin.org)
- Coxiella burnetti bacteria, coloured transmission electron micrograph (TEM). (sciencephoto.com)
- In contrast, Coxiella burnetii bacteria live and replicate in acidified compartments with phagolysosomal characteristics ( 23 ). (asm.org)
- This method provides insight into coxiella pathogensis and can also be applied to investigate the host pathogen interactions of other bacteria that depend on efficient protein translocation. (jove.com)
- As observed in other gram-negative bacteria, Tn7 inserts with high frequency into a single intergenic site downstream from Coxiella glmS encoding glucosamine-6-phophosphate synthetase. (grantome.com)
- The PhoBR two-component system of Coxiella is especially intriguing as homologous systems in other bacteria regulate virulence gene expression. (grantome.com)
- As an amenable model to help better understand the biological relevance of Coxiella differentiation, we established that SCV/LCV transitions are recapitulated by organisms growing in the third-generation axenic media, ACCM-D. This discovery enables studies of Coxiella developmental biology without experimental difficulties encountered with host cell-propagated bacteria. (grantome.com)
- However, with the discovery and study of Coxiella-like bacteria (CLB), many PCR genes targeted in routine molecular detection assays were found to also be present in CLB. (edu.au)
Abstract1
- abstract = "Milk samples of 12 Danish dairy herds were collected 3 times during an 11-mo period and tested for Coxiella burnetii DNA by real-time PCR, detecting the IS1111 element, and for the presence of antibodies against the bacterium by ELISA. (dtu.dk)
Pathogen7
- Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella -containing vacuole (CCV). (asm.org)
- The pathogen persists in the environment as a metabolically quiescent small cell variant (SCV), which transforms into a metabolically active large cell variant (LCV) within a lysosome-derived, acidic (pH ~4.5), Coxiella -containing vacuole (CCV) ( Voth and Heinzen, 2007 ). (frontiersin.org)
- The pathogen employs a type 4B secretion system (T4BSS) to deliver effector proteins into the host cell that modify the Coxiella- containing vacuole (CCV) into a replication-permissive niche. (asm.org)
- The obligate intracellular pathogen Coxiella burnetii has long been considered the most heat resistant pathogen in raw milk, making it the reference pathogen for determining pasteurisation conditions for milk products. (unboundmedicine.com)
- An obligate intracellular bacterial pathogen, Coxiella survives and multiplies in a large lysosome‐like vacuole known as the Coxiella parasitophorous vacuole (CPV). (iupui.edu)
- Coxiella burnetii is an important zoonotic pathogen of global distribution. (biomedcentral.com)
- Using Himar1, we have generated mCherry and GFP-expressing Coxiella useful for host-pathogen interaction studies. (grantome.com)
Vacuole9
- The Coxiella burnetii parasitophorous vacuole. (nih.gov)
- Coxiella burnetii is a bacterial intracellular parasite of eucaryotic cells that replicates within a membrane-bound compartment, or "parasitophorous vacuole" (PV). (nih.gov)
- Fusogenicity of the Coxiella burnetii parasitophorous vacuole. (nih.gov)
- This study investigated whether C. burnetii protein synthesis and replication is required for maintenance of the fusogenic character of the Coxiella parasitophorous vacuole (PV). (nih.gov)
- IMPORTANCE Coxiella burnetii is an intracellular pathogenic bacterium that replicates within a lysosomal vacuole. (asm.org)
- Biogenesis of the Coxiella -containing vacuole (CCV) requires effector proteins delivered into the host cell cytosol by the type 4B secretion system (T4BSS). (asm.org)
- By mechanisms not fully understood, C. burnetii resists degradation by acid hydrolases delivered by ongoing fusion of lysosomes with the Coxiella -containing vacuole (CCV). (asm.org)
- Furthermore, 3-methyladenine and wortmannin, agents known to inhibit early stages in the autophagic process, each blocked Coxiella vacuole formation. (asm.org)
- It has been previously described that both the endocytic and autophagic pathways contribute to the Coxiella replicative vacuole (CRV) generation. (gob.ar)
Antibodies7
- Background and Aim: In the course of our Indian Council of Medical Research project on coxiellosis in Puducherry and Tamil Nadu, 5.64% goat, 1.85% sheep, 1.06% buffaloes, and 0.97% cattle were positive for Coxiella burnetii antibodies by enzyme linked immunosorbent assay kit (IDEXX, Liebefeld, Switzerland). (doaj.org)
- Prevalence of Coxiella burnetii antibodies in wild ruminants in Kavecany zoo, Kosice, eastern Slovakia. (aaem.pl)
- Prevalence of antibodies to Coxiella burnetii among farming population in eastern Poland. (aaem.pl)
- The presented study aims to determine the seroprevalence of Coxiella burnetii antibodies in healthy adults of four different regions in Chile. (biomedcentral.com)
- The aim of this study was to determine the seroprevalence of anti- Coxiella burnetii antibodies in healthy inhabitants of four different Chilean regions and to analyze possible geographical differences. (biomedcentral.com)
- 9. SAMPLE ANALYSIS A commercial ELISA antibody test kit (SERION ELISA classic Coxiella burnetii Phase 1 IgG) (www.virion-serion.de) was used for the detection of human Coxiella burnetii antibodies in serum. (slideshare.net)
- Bulk tank milk (BTM) samples were collected from 81 sheep flocks in the Basque Country, Spain, in 2015 and were analysed for antibodies against Coxiella burnetii by ELISA and for C. burnetii DNA by real-time PCR. (biomedcentral.com)
Burnetti6
- Man can be infected with the germ (Coxiella Burnetti) following contact with infected animals or products from these animals, urine, faeces or milk birth products. (thetraveldoctor.com.au)
- Coxiella burnetti , Mycobacterium leprae), and protozoa. (thefreedictionary.com)
- Serum for Legionella pneumophila, Mycoplasma pneumoniae, and Coxiella burnetti serology was collected. (thefreedictionary.com)
- Alternatively, Coxiella burnetti endocarditis infections only require a single positive blood culture. (thefreedictionary.com)
- The qPCR assays include specific chemistries for the identification of Bacillus anthracis, Francisella tularensis, Yersinia pestis, Coxiella burnetti , Brucella spp. (thefreedictionary.com)
- Literaturde grup A streptokok, Epstein-Barr virus, Coxiella burnetti , Pasteurella multocida, Helicobacter pylori, Aspergillus, Varisella zoster ile iliskili bulunarak yayinlanmis MFS olgulari da vardir (8-14). (thefreedictionary.com)
Prevalence7
- Prevalence of Coxiella burnetii infections among North Dakota sheep producers. (cdc.gov)
- The prevalence of Coxiella burnetii in Iran is essentially unknown. (thescipub.com)
- Our results indicated that Caprine is more sensitive than Ovine to Coxiella burnetii 's abortion Khozestan and Gilan have the highest and Khorasan and Sistan va Baluchistan provinces have the lowest prevalence of Coxiella burnetii , respectively. (thescipub.com)
- To our knowledge, this study is the first prevalence report of direct identification of Coxiella burnetii in aborted Ovine and Caprine fetuses by evaluation of nested and real-time PCR assays in Iran. (thescipub.com)
- Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana. (microbiologyresearch.org)
- Prevalence of Coxiella burnetii and Brucella spp. (biomedcentral.com)
- A study based on bulk tank milk samples from 120 randomly selected dairy cattle herds was conducted to estimate the prevalence of Coxiella burnetii seropositive dairy herds, to describe the geographical distribut. (biomedcentral.com)
Infections2
- [1] X Trustworthy Source Centers for Disease Control and Prevention Main public health institute for the US, run by the Dept. of Health and Human Services Go to source Unlike many other bacterial infections, Coxiella burnetii is resistant to heat and to dry climate, and also shows resistance to common household disinfectants. (wikihow.com)
- sheep farms, were identified as the major source of these human infections with high Coxiella burnetii shedding rates during parturition of the animals. (uu.nl)
Virulence7
- Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal. (semanticscholar.org)
- A unique characteristic of the CPV is the acidic environment (pH ∼5.0), which is required to activate Coxiella metabolism and the Coxiella type 4 secretion system (T4SS), a major virulence factor required for intracellular survival. (iupui.edu)
- Together, these data suggest that CPV pH is an important limiting factor for Coxiella growth and virulence. (iupui.edu)
- Our results provide new insight into the genetic diversity and virulence potential of Coxiella species. (nih.gov)
- Collectively, our repertoire of Coxiella genetic tools now allows traditional mutation and complementation strategies for virulence factor discovery. (grantome.com)
- The only genetic lesions proven to result in attenuated Coxiella virulence in an immunocompetent animal model are associated with defective LPS synthesis. (grantome.com)
- Given the critical role of LPS in Coxiella virulence, it is important to understand the molecular basis of phase variation. (grantome.com)
Genus3
- However, the identification of Coxiella cheraxi in crayfish (Cherax quadricarinatus) (21) and other Coxiella-like endosymbionts suggests that there is far more genetic diversity within the genus than previously perceived. (thefreedictionary.com)
- The type species of the genus Coxiella . (thefreedictionary.com)
- Different species of ticks harbor a symbiont bacterium of the genus Coxiella. (gob.ar)
Organism3
- The first description of what may have been Coxiella burnetii was published in 1925 by Hideyo Noguchi, but since his samples did not survive, it remains unclear as to whether it was the same organism. (wikipedia.org)
- A negative result does not negate the presence of the organism or active disease, as false-negative results may occur due to inhibition of PCR, sequence variability underlying the primers and probes, or the presence of Coxiella burnetii in quantities less than the limit of detection of the assay. (mayomedicallaboratories.com)
- The lack of methods to genetically manipulate Coxiella significantly impedes study of the organism. (grantome.com)
Macrophages4
- To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. (frontiersin.org)
- Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. (prolekare.cz)
- These studies have confirmed that T4BSS function is critical for Coxiella growth in macrophages. (grantome.com)
- Coxiella burnetii alters cyclic AMP-dependent protein kinase signaling during growth in macrophages. (sparrho.com)
Pathogenesis1
- We found that Coxiella genetic diversity correlates with disease pathogenesis. (grantome.com)
Characterization3
- Cloning and characterization of an autonomous replication sequence from Coxiella burnetii. (semanticscholar.org)
- Characterization of a Coxiella burnetii ftsZ mutant generated by Himar1 transposon mutagenesis. (semanticscholar.org)
- Molecular characterization of Coxiella burnetii isolates by infrequent restriction site-PCR and MLVA typing. (microbiologyresearch.org)
Goats2
- Coxiella brunetii has a broad host range but is detected primarily in sheep, goats, cattle and wild ruminants. (bund.de)
- This is because animals such as cows and goats harbor ''Coxiella burnetii'' in large amounts, providing many opportunities for those working in agriculture to become infected. (kenyon.edu)
Type IVB secretion1
- Indeed, we have constructed knockout strains in both virulent and avirulent Coxiella, including those with deletions in genes encoding components of the Dot/Icm type IVB secretion system (T4BSS) and secreted proteins. (grantome.com)
Ticks3
- Five spawns of Rhipicephalus sanguineus ticks in- Bacteriageneticallyrelatedto Coxiella burnetii havebeen fected with Candidatus C. massiliensis were used for an- found in ticks. (cdc.gov)
- A Coxiella-type microbe occurs at 100% frequency in all Amblyomma americanum ticks thus far tested. (semanticscholar.org)
- Laboratory-reared and field-collected Amblyomma americanum ticks were hosts of a Coxiella sp. (semanticscholar.org)
Gene6
- long portion of the groEL gene of Coxiella spp. (cdc.gov)
- Mayo Medical Laboratories has developed a real-time PCR test that rapidly detects Coxiella burnetii DNA in clinical specimens by targeting a sequence of the shikimate dehydrogenase gene ( aroE ) unique to Coxiella burnetii . (mayomedicallaboratories.com)
- Here, we describe the necessary techniques to measure effector translocation by Coxiella burnetii during siRNA gene silencing using BlaM substrate. (jove.com)
- Moderate (CBU1169) and strong (CBU0311;outer membrane protein P1) promoters have been defined for driving gene expression in Coxiella. (grantome.com)
- Moreover, we are expressing dominant/negative proteins in Coxiella using these vectors which will also be critical in complementation studies of forthcoming Coxiella gene knockouts (discussed below). (grantome.com)
- Finally, suicide plasmids with ColE1/pUC replicons containing a cloned version of a Coxiella gene interrupted with an antibiotic resistance gene are currently being tested to promote allelic exchange. (grantome.com)
Species2
- The presently recommended conditions of "high-temperature, short-time" pasteurization at 71.5°C for 15 seconds are adequate to destroy viable Coxiella species. (microbenotes.com)
- Other wildlife samples were found to be positive for Coxiella, but the species remained undetermined. (edu.au)
Antibody1
- The aim was to identify risk factors associated with Coxiella burnetii antibody positivity in bulk tank milk (BTM) samples from 100 randomly selected Danish dairy cattle herds. (biomedcentral.com)
Burnetii seroprevalence2
- Coxiella burnetii seroprevalence and associated risk factors in dairy and mixed cattle farms from Ecuador. (springer.com)
- Potential association between Coxiella burnetii seroprevalence and selected risk factors among veterinary students in Slovakia. (aaem.pl)
Transmission electron m2
- Transmission electron micrograph of Candidatus Coxiella massiliensis taken with a Morgagni 268D microscope (Philips, Endhoven, the Netherlands) at an operating voltage of 60 kV. (cdc.gov)
- False colour transmission electron micrograph of Coxiella burnettii growing in a placental cell. (sciencephoto.com)
Strictly intracellular bacterium1
- Coxiella burnetii is a strictly intracellular bacterium. (asm.org)
Dairy1
- Coxiella burnetii shedding and environmental contamination at lambing in two highly naturally-infected dairy sheep flocks after vaccination. (springer.com)
Genome5
- Work on the genome structure of ''Coxiella ''is still in progress. (kenyon.edu)
- Another plasmid, [http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=15234 ''Coxiella burnetii'' plasmid QpDV], was sequenced in 1999. (kenyon.edu)
- Work has also been done on [http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=293 ''Coxiella burnetii'' RSA 493]. (kenyon.edu)
- One of the more recent developments is the sequencing of [http://www.ncbi.nlm.nih.gov/genomes/framik.cgi?db=Genome&gi=17002 ''Coxiella burnetii'' RSA 493 plasmid pQpH1], completed in 2003. (kenyon.edu)
- Coxiella plates with high efficiency on ACCM-2 agarose ( 1 to 2 genome equivalents per colony) and the resulting contain clonal populations. (grantome.com)
Pathways2
- Additionally, by using chemical agents that block heme and biotin biosyntheses, we show that these pathways are promising targets for the development of new anti- Coxiella therapies. (frontiersin.org)
- 5. Heinzen RA, Scidmore MA, Rockey DD, Hackstadt T. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. (prolekare.cz)
Symbiont2
- Localization and visualization of a coxiella-type symbiont within the lone star tick, Amblyomma americanum. (semanticscholar.org)
- It was showed that a Coxiella endosymbiont from R. microplus (CERM) is a vertically transmitted mutualist symbiont, comprising 98% of the 16S rRNA sequences in both eggs and larvae. (gob.ar)
Detection2
- 1. Frangoulidis D, Meyer H, Kahlhofer C, Splettstoesser WD: 'Real-time' PCR-based detection of Coxiella burnetii using conventional techniques. (mayomedicallaboratories.com)
- In this present study, for more sensitive and accurate detection and prevalence's determination of Coxiella burnetii in aborted Ovine and Caprine fetuses, the nested and real-time PCR methods are recommended. (thescipub.com)
Risk factors2
- This is the first cross-sectional study of the seroprevalence and risk factors for Coxiella burnetii in Jordan. (ajtmh.org)
- The current project was based on these two pilot studies and aimed at (1) modelling the airborne dispersion of Coxiella burnetii in the environment with a focus on farm-to-human transmission, and (2) identifying environmental risk factors for the transmission of Coxiella burnetii from infected farms to humans. (uu.nl)
Ruminants1
- Genotyping of Coxiella burnetii from domestic ruminants in northern Spain. (microbiologyresearch.org)
Genotypes1
- Maximum parsimony phylogeny of 35 MST genotypes for Coxiella burnetii . (cdc.gov)
Serum1
- We have now developed a serum-free version of ACCM termed ACCM-2 that supports improved Coxiella growth in both liquid and solid media. (grantome.com)
Genetic3
- Physical and genetic map of the obligate intracellular bacterium Coxiella burnetii. (semanticscholar.org)
- ACCM-2 will facilitate biochemical studies and, as described below, aid development of Coxiella genetic systems. (grantome.com)
- 2) Development of new tools for Coxiella genetic manipulation. (grantome.com)
Replication1
- A Coxiella burnetii chromosomal fragment capable of functioning as an origin for the replication of a kanamycin resistance (Kanr) plasmid was isolated by use of origin search methods utilizing an Escherichia coli host. (semanticscholar.org)