A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.
A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The part of the face above the eyes.
A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
Established cell cultures that have the potential to propagate indefinitely.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
A specificity protein transcription factor that regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.
The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
A family of transcription factors that control EMBRYONIC DEVELOPMENT within a variety of cell lineages. They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.
An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Nucleic acid sequences involved in regulating the expression of genes.
An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.
Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.
A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.
An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.
A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.
A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.
A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
A cell line derived from cultured tumor cells.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
A GATA transcription factor that is expressed predominately in SMOOTH MUSCLE CELLS and regulates vascular smooth muscle CELL DIFFERENTIATION.
An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A transcription factor that takes part in WNT signaling pathway where it may play a role in the differentiation of KERATINOCYTES. The transcriptional activity of this protein is regulated via its interaction with BETA CATENIN.
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.
A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
An RNA POLYMERASE II specific transcription factor. It may play a role in transcriptional activation of gene expression by interacting with the TATA-BOX BINDING PROTEIN component of TRANSCRIPTION FACTOR TFIID.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. It is a binding partner for E2F TRANSCRIPTION FACTORS and enhances the DNA binding and transactivation function of the DP-E2F complex.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
Proteins found in any species of fungus.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
A ubiquitously expressed octamer transcription factor that regulates GENETIC TRANSCRIPTION of SMALL NUCLEAR RNA; IMMUNOGLOBULIN GENES; and HISTONE H2B genes.
Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Proteins prepared by recombinant DNA technology.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.
A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Factors that bind to RNA POLYMERASE III and aid in transcription. They include the assembly factors TFIIIA and TFIIIC and the initiation factor TFIIIB. All combine to form a preinitiation complex at the promotor that directs the binding of RNA POLYMERASE III.
A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Deletion of sequences of nucleic acids from the genetic material of an individual.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A family of low-molecular weight, non-histone proteins found in chromatin.
Proteins found in any species of bacterium.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN. Transcription factor 7-like 2 protein plays an important role in the embryogenesis of the PANCREAS and ISLET CELLS.
An ets proto-oncogene expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.
Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The biosynthesis of DNA carried out on a template of RNA.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A basic helix-loop-helix transcription factor that was originally identified in DROSOPHILA as essential for proper gastrulation and MESODERM formation. It plays an important role in EMBRYONIC DEVELOPMENT and CELL DIFFERENTIATION of MUSCLE CELLS, and is found in a wide variety of organisms.
A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.
Transport proteins that carry specific substances in the blood or across cell membranes.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signaling pathways.
One of several general transcription factors that are specific for RNA POLYMERASE III. TFIIIB recruits and positions pol III over the initiation site and remains stably bound to the DNA through multiple rounds of re-initiation by RNA POLYMERASE III.
Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.
One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
A family of mammalian POU domain factors that are expressed predominately in NEURONS.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
A subclass of SOX transcription factors that are expressed in neuronal tissue where they may play a role in the regulation of CELL DIFFERENTIATION. Members of this subclass are generally considered to be transcriptional activators.
Formation of an acetyl derivative. (Stedman, 25th ed)
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
A heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
A species of fruit fly much used in genetics because of the large size of its chromosomes.
A subclass of closely-related SOX transcription factors. Members of this subfamily have been implicated in regulating the differentiation of OLIGODENDROCYTES during neural crest formation and in CHONDROGENESIS.
Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
Elements of limited time intervals, contributing to particular results or situations.
A family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to alpha-amanitin in comparison to RNA polymerase I and II. EC 2.7.7.6.

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. (1/113)

The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development.  (+info)

Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. (2/113)

talpid3 is an embryonic-lethal chicken mutation in a molecularly un-characterised autosomal gene. The recessive, pleiotropic phenotype includes polydactylous limbs with morphologically similar digits. Previous analysis established that hox-D and bmp genes, that are normally expressed posteriorly in the limb bud in response to a localised, posterior source of Sonic Hedgehog (Shh) are expressed symmetrically across the entire anteroposterior axis in talpid3 limb buds. In contrast, Shh expression itself is unaffected. Here we examine expression of patched (ptc), which encodes a component of the Shh receptor, and is probably itself a direct target of Shh signalling, to establish whether talpid3 acts in the Shh pathway. We find that ptc expression is significantly reduced in talpid3 embryos. We also demonstrate that talpid3 function is not required for Shh signal production but is required for normal response to Shh signals, implicating talpid3 in transduction of Shh signals in responding cells. Our analysis of expression of putative components of the Shh pathway, gli1, gli3 and coupTFII shows that genes regulated by Shh are either ectopically expressed or no longer responsive to Shh signals in talpid3 limbs, suggesting possible bifurcation in the Shh pathway. We also describe genetic mapping of gli1, ptc, shh and smoothened in chickens and confirm by co-segregation analysis that none of these genes correspond to talpid3.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (3/113)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter. (4/113)

Seven mutations in the hepatocyte nuclear factor (HNF)-4alpha gene have been shown to correlate with type 1 maturity-onset diabetes of the young (MODY 1), a monogenic form of type 2 diabetes. Up to now, only the functional properties of two MODY 1 HNF-4alpha mutants, Q268X and V393I, have been investigated to address how the mutations in the HNF-4alpha gene, found by genetic studies, can give rise to impaired activities of mutated HNF-4alpha proteins and can cause this disease. The E276Q mutation results in a nonconservative substitution occurring in the HNF-4alpha E domain, which is involved in dimerization and transactivation activities as well as in protein-protein interactions with other transcription factors or coactivators. Using the mutated human HNF-4alpha2, we have found that, in the absence of chicken ovalbumin upstream promoter transcription factor II (COUP TFII), the E276Q substitution does not significantly affect the dimerization and transactivating activities of HNF-4alpha, at least on the promoters studied herein. On the other hand, in the presence of COUP TFII, the substitution impairs the enhancement of HNF-4-mediated activation of HNF-1 promoter. The impaired synergy between COUP TFII and HNF-4 on the HNF-1 promoter results from an alteration of their interaction. HNF-1 expression plays a crucial role in transactivation of insulin promoter and of numerous genes coding for enzymes involved in glucose homeostasis. Therefore, its downregulation resulting from the E276Q mutation in HNF-4alpha gene most probably impairs the function of pancreatic beta-cells.  (+info)

Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. (5/113)

Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase CYP26. Subsequently in the embryonic retina, CYP26 forms a narrow horizontal boundary between the dorsal and ventral dehydrogenases, creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal and ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns.  (+info)

Sagittal band expression of COUP-TF2 gene in the developing cerebellum. (6/113)

In the developing cerebellum, the medio-lateral compartmentalization of the adult cerebellum is preceded by the transient expression of factors which divide the cortex into similar parasagittal stripes. Here we report that COUP-TF2, an orphan member of the nuclear receptor family which suppresses RA actions by forming heterodimers with RXR, shows a pattern of sagittal bands in developing mouse cerebellum. The band pattern changes according to the developmental stage. At embryonic day 13 it is expressed in the lateral half of the cerebellum, but at later stages the expression is divided into several parasagittal bands. By postnatal day 5 the COUP-TF2 expression substantially decreases to low, but detectable, levels.  (+info)

Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response. (7/113)

Transcription of the L-type pyruvate kinase (L-PK) gene is induced by glucose in the presence of insulin and repressed by glucagon via cyclic AMP. The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs). From ex vivo and in vivo experiments, it appears that USFs are required for correct response of the L-PK gene to glucose, but their expression and binding activity are not known to be regulated by glucose. A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i.e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). Binding of COUP-TFII to the GlRE was confirmed by electrophoretic mobility shift assays, and COUP-TFII-containing complexes were detectable in liver nuclear extracts. Neither abundance nor binding activity of COUP-TFII appeared to be significantly regulated by diets. In footprinting experiments, two COUP-TFII-binding sites overlapping the E boxes were detected. Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. In addition, a mutated GlRE with increased affinity for USF and very low affinity for COUP-TFII conferred a dramatically decreased glucose responsiveness on the L-PK promoter in hepatocytes in primary culture by increasing activity of the reporter gene in low glucose condition. We propose that COUP-TFII could be a negative regulatory component of the glucose sensor complex assembled on the GlRE of the L-PK gene and most likely of other glucose-responsive genes as well.  (+info)

Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells. (8/113)

Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system (CNS) and plays a direct role in the pathogenesis of AIDS dementia. However, mechanisms underlying HIV-1 gene expression in the CNS are poorly understood. The importance of CCAAT/enhancer binding proteins (C/EBP) for HIV-1 expression in cells of the immune system has been recently reported. In this study, we have examined the role and the molecular mechanisms by which proteins of the C/EBP family regulate HIV-1 gene transcription in human brain cells. We found that NF-IL6 acts as a potent activator of the long terminal repeat (LTR)-driven transcription in microglial and oligodendroglioma cells. In contrast, C/EBPgamma inhibits NF-IL6-induced activation. Consistent with previous data, our transient expression results show cell-type-specific NF-IL6-mediated transactivation. In glial cells, full activation needs the presence of the C/EBP binding sites; however, NF-IL6 is still able to function via the minimal -40/+80 region. In microglial cells, C/EBP sites are not essential, since NF-IL6 acts through the -68/+80 LTR region, containing two binding sites for the transcription factor Sp1. Moreover, we show that functional interactions between NF-IL6 and Sp1 lead to synergistic transcriptional activation of the LTR in oligodendroglioma and to mutual repression in microglial cells. We further demonstrate that NF-IL6 physically interacts with the nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF), via its DNA binding domain, in vitro and in cells, which results in mutual transcriptional repression. These findings reveal how the interplay of NF-IL6 and C/EBPgamma, together with Sp1 and COUP-TF, regulates HIV-1 gene transcription in brain cells.  (+info)

Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
1. Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metabolism. 2008; 7:86-94. PMCID:PMC2278019. 2. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA. 2008; 105: 2421-2426. PMCID:PMC2268152. 3. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, and Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010. 143; 156-169. PMCID:PMC2950833. 4. Eguchi J, Wang X, Yu S, Kershaw EE, Chui PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, and Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metabolism. 2011; 13: 249-259. PMCID: PMC3063358. 5. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong S-E, and Rosen ED. FOSL2 promotes adipocyte-specific leptin gene ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Alias: NR2F2, ARP1, ARP-1, COUP transcription factor II, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, COUPTFII, COUP transcription factor 2, EAR3, NF-E3, SVP40, COUPTF-II, TFCOUP2 ...
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
Gtf2ird1 (untagged) - Mouse general transcription factor II I repeat domain-containing 1 (Gtf2ird1), transcript variant 9, (10ug), 10 µg.
In the mosquito Aedes aegypti, vitellogenesis is activated via an ecdysteroid hormonal cascade initiated by a blood meal. The functional ecdysone receptor is a heterodimer composed of the ecdysone receptor (EcR) and ultraspiracle, the homolog of the retinoid X receptor. The precise tuning of this hormonal response requires participation of both positive and negative transcriptional regulators. In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor complex-mediated transactivation in vitro and in vivo. Here we report the cloning and characterization of the Svp homolog in mosquito Aedes aegypti, AaSvp. It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. AaSvp transcripts and protein are present in the fat body at high levels from the state of arrest to about 60 h post blood meal. AaSvp binds strongly to a variety of direct repeats of the sequence AGGTCA, but weakly to ...
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Very well explained, thank you very much. The div structure you mention is the one I used, but the background image (film strip) was in the wrong div. Locally, on my machine, I corrected the situation: I put the background image (film strip) in the container, and removed it from menuside. Now it appears ok in IE6 but not in Firefox nor Chrome. On those 2 browsers, the film strip does not go down all the way.. Using Firebug, I can see the container stops about 1/3 of content side??? How can it be possible?. I just made some more tests and I can see that when I reduce the browser window (firefox and chrome), the film strip shortens too! It looks like the height of the container varies with the height of the browsers window (no matter the size of the contentside), with some kind of fixed offset from the bottom of the window.. The maximum height of the film strip (or container) seems to be reached when the browser window is maximized to full screen. (I wish I would have a longer ...
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. NR2F6 serves as an antigen receptor signaling threshold-regulated barrier against autoimmunity where NR2F6 is part of a negative feedback loop that limits inflammatory tissue damage induced by weakly immunogenic antigens such as self-antigens. Under such low affinity antigen receptor stimulation, NR2F6 appears as a prototypical repressor that functions to
Regional and cell-type specification during embryogenesis are often coupled to expression of TFs that are restricted to specific progenitor domains. Here, we found that Nkx2-1 restricts the expression of Coup-TF1/2 in the MGE to an arc that extended from a small rostrodorsal domain to a larger caudoventral domain (Fig. 1; Fig. S1B,D,H,K,L). The Coup-TF1/2+ MGE domain was complementary to an Otx2+ domain (Fig. S1B-E), where Otx2 represses Coup-TF1 MGE expression (Hoch et al., 2015a,b).. Our data support a model in which the Coup-TF1/2+ MGE domain is biased towards generating SST+ CINs (Fig. 2; Fig. S3A-C), as well as cholinergic and pallidal neurons (Fig. S4). These conclusions differ from other publications regarding the major location for the origin of SST+ interneurons, and provide evidence for a Coup-TF1/2-dependent activation of Sox6 expression that promotes SST+ interneuron development.. Multiple lines of evidence show that Coup-TF1/2 have key roles in promoting SST+ interneuron ...
Looking for online definition of COUP-TF I in the Medical Dictionary? COUP-TF I explanation free. What is COUP-TF I? Meaning of COUP-TF I medical term. What does COUP-TF I mean?
Rasd1 is becoming somewhat of avant-garde member of the Ras family of GTPases by performing many non-conventional signaling functions. Our identification of Rasd1 in Avp neurons starts a new chapter for this small GTPase. Here we show that Rasd1 is rapidly induced by stress in the PVN, and by elevated plasma osmolality in the PVN and SON of the hypothalamus. We propose that the abundance of RASD1 in MCN and PCNs, based on its inhibitory actions on CREB phosphorylation, is an important mechanism for controlling the transcriptional responses to stressors in both the PVN and SON. In MCN we show, by virally mediated overexpression of Rasd1, that Rasd1 inhibits HS induced stimulation of cAMP inducible genes. When a CAAX box deficient mutant form of Rasd1 is expressed in the SON cAMP inducible genes were further increased by SL. These effects likely occur through modulation of cAMP-PKA-CREB signaling pathway.. Our interest in Rasd1 began following identification increased expression of this gene in ...
Sediqque Mir Mateen. Sediqque Mir Mateen stated of his son, We were in Downtown Miami, Bayside, people were playing music. And he saw two men kissing each other in front of his wife and kid and he got very angry. They were kissing each other and touching each other and he said, Look at that. In front of my son they are doing that. And they were in the mens bathroom and men were kissing each other. He has also apologized for his sons actions. A former classmate of Mateens stated the terrorist was gay, a claim his father denies, If he was gay, why would he do something like this. The list of gay bars Mateens classmate stated they visited have all stated they do not recognize him. However, some of the staff at Pulse recognized him, stating he had visited the club in the past. Mateen was clearly studying the club and planning an attack, which he executed to deadly results. RELATED ARTICLE. 20 People Shot In A Gay And Lesbian Night Club In Orlando, Florida Where Hostages Are Being Held By ...
Bereken de fiscale bijtelling van je Audi A5 Coupé 2.0 TFSI 211pk quattro Pro Line S. Zie exact wat een auto van de zaak aan netto bijtelling kost.
Egyptian coup detat - Get latest news on Egyptian coup detat. Read Breaking News on Egyptian coup detat updated and published at Zee News
Ze studie 407 Prologue se zrodil Peugeot 407 Coup . Sv tov premi ra je p ipravena na z iov Frankfurt. Z kladn cena by m la atakovat milionovou hranici.
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Coup De Gráce testo canzone cantato da 360: Ayy They wanna know where 6 at (6 at) When I hit em with this track they would likely...
Complete information for RASD2 gene (Protein Coding), RASD Family Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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The general transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] Before the start of transcription, the transcription factor II D (TFIID) complex, binds to the core promoter of the gene. TFIID is the first protein to bind to DNA during the formation of the pre-initiation transcription complex of RNA polymerase II (RNA Pol II). Binding of TFIID to the TATA box in the promoter region of the gene initiates the recruitment of other factors required for RNA Pol II to begin transcription. Some of the other recruited transcription factors include TFIIA, TFIIB, and TFIIF. Each of these transcription factors is formed from the interaction of many protein subunits, indicating that transcription is a heavily regulated process. Several of the TFIID subunits have been implicated in core promoter selectivity (Verrijzer and Tijan, 1996; Hampsey and Reinberg, 1997; Smale, 1997; Hahn, 1998).[2] ...
Looking for online definition of Coup d'etát in the Medical Dictionary? Coup d'etát explanation free. What is Coup d'etát? Meaning of Coup d'etát medical term. What does Coup d'etát mean?
The president blames a self-exiled cleric in the U.S. for the failed coup, Turkey rounds up collaborators and world and NATO relations could see changes.
After months of political crisis, the generals declare martial law. They claim theyre just making peace, not running the country.
2011 was a year of bigger deals and fewer exits for venture-backed companies, according to data being released today by Dow Jones VentureSource.
In a major coup the Socceroos will have the opportunity to compete with the best in the world next year after a historic agreement.
Synonyms for Sport coupé in Free Thesaurus. Antonyms for Sport coupé. 5 words related to coupe: auto, automobile, car, motorcar, machine. What are synonyms for Sport coupé?
The Cayenne Coupé models have active aerodynamics, as do the Cayenne Turbo and Cayenne Turbo S E-Hybrid. Active slats in the front air intakes enable the combustion engine to be efficiently cooled. In the Cayenne Coupé models, the adaptive rear spoiler extends by 135mm, also ensuring the appropriate downforce for every situation. While the adaptive roof spoiler on the Cayenne Turbo provides stabilising contact pressure on the rear axle while driving. In the air brake position, this helps to shorten braking distances ...
The Cayenne Coupé models have active aerodynamics, as do the Cayenne Turbo and Cayenne Turbo S E-Hybrid. Active slats in the front air intakes enable the combustion engine to be efficiently cooled. In the Cayenne Coupé models, the adaptive rear spoiler extends by 135mm, also ensuring the appropriate downforce for every situation. While the adaptive roof spoiler on the Cayenne Turbo provides stabilising contact pressure on the rear axle while driving. In the air brake position, this helps to shorten braking distances ...
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
In this video, Alex explains why there has been a coup détat against our Constitutional Republic, and breaks down why the office of the presidency is becoming dictatorial.. Read: Retired Army Captain Warns DHS Acquisitions are bold threat of war Against the American People - http://www.infowars.com/retired-army-captain-warns-recent-dhs-acquisitions-are-bold-threat-of-war… ...
The Brazilian Coups Image Problem from Boston Review. New leaks prove the impeachment is intended to protect corrupt politicians.
Oracle Corp ORCL.O said on Thursday it was moving its stock listing to the New York Stock Exchange from Nasdaq OMX Groups (NDAQ.O) main U.S. exchange, a major coup for NYSE Euronext NYX.N, as it lands the largest-ever U.S. market transfer.
Former House Majority Leader Dick Armey (R-Texas), who abruptly resigned as head of Tea Party group FreedomWorks, brought in an assistant with a gun in an apparent coup attempt at the group, according to a report in the Washington Post. | this curious life
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
WHY WE LOVE IT Bread van of-fers a slice of the VW ac-tion at low prices The Polo MkII was a prac-ti-cal re-think of the orig-i-nal VW su-per-mini (1975-1981), and was ini-tially avail-able with a squared-off back end and big rear win-dows, like a com-pact es-tate car that fans af-fec-tion-ately named the bread van. The ar-rival of the coupé ver-sion from 1983 of-fered a more tra-di-tional slop-ing hatch-back style.. En-gine sizes ranged from 895cc to 1272cc, but who can for-get the leg-endary su-per-charged 116bhp G40 in-tro-duced in 1991, thats ca-pa-ble of a top speed of 120mph?. Per-haps spurred on by the G40, Polo MkIIs have a strong fol-low-ing - par-tic-u-larly among mod-i-fiers - though theres good avail-abil-ity of most types and some re-ally great bar-gains to be had out there. BUY-ING TIPS. As ever, rust is the big po-ten-tial prob-lem - take a good look at those door bot-toms. Also check for signs of ac-ci-dent dam-age, break-ins and poor re-pair work.. Reg-u-lar oil changes ...
Thousands of public servants dismissed in state of emergency decrees have applied to the European Court of Human Rights (ECHR) since Turkeys July 2016 coup attempt.
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
Intelligence sources say the Bangladesh coup attempt last month was fueled by retired officers campaigning to introduce sharia law. The news raises concern about political instability in the region.
Turkey has reportedly made a formal request to the United States for the arrest of U.S.-based Turkish cleric Fethullah Gulen on charges of orchestrating an attempted military coup on July 15. Mana Rabiee reports.}
Thailands prime minister appears set to win a parliamentary vote for a second term in office five years after he took power in a military coup
This is an ongoing situation, I assume no members are currently in the country. If you are then follow FCO advice, if youre a Turkish citizen then TOR and...
Coup de cœur pour le travail de Juan Alfonso Solis : un graphiste espagnol basé en Irlande qui a imaginé lidentité graphique du lieu Le 29,
This barely released thriller, Any Mans Death, offers one dunderheaded miscasting coup after another. Waspy John Savage plays a Jewish…
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ...
"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11B has been shown to interact with COUP-TFI. BCL11B is closely connected with immune regulation and for so its mutation can ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ...
... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11A was initially discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (December 2002). "COUP-TF ( ...
Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746. Hartley, D. and Cooper, G.M. ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and ... Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ...
... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ...
... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ... RARE-like plays a role in transcription regulation of CERK. It is suspected that in the presence of all-trans retinoic acid ( ...
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...
... (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe- ... "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207-16. PMC 5952191. PMID ...
... may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ... humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor ...
Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen ... Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hERα-COUP-TFI ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ... heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress Chaperones. 1 (4): 237-50. doi:10.1379/ ...
COUP+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) COUP+Transcription+Factor+I ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ... intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the ... Park JI, Tsai SY, Tsai MJ (2003). "Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) ...
This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... Besides these, NR4A1 can mediate T cell function, the transcription factor NR4A1 is stably expressed at high levels in tolerant ... Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is ...
The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ... Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ...
Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a ... Tanaka S, Ueo H, Mafune K, Mori M, Wands JR, Sugimachi K (May 2001). "A novel isoform of human fibroblast growth factor 8 is ...
The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ...
Consisting of about 110 amino acids, the domain in winged-helix transcription factors (see Regulation of gene expression) has ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ... Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single ...
V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...
... coup transcription factor i MeSH D12.776.930.682.074.500 - coup transcription factor ii MeSH D12.776.930.682.350.174 - estrogen ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk transcription factor MeSH D12.776.930.127.656.770 - nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk transcription factor MeSH D12.776.930.316.750.770 - nf-e2 ...
... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ... fibroblast growth factor 4 MeSH D12.776.624.664.700.112 - fibroblast growth factor 6 MeSH D12.776.624.664.700.114 - fms-like ...
... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 ( ... "Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine ...
第二亚族(COUP-TF(英语:Chicken ovalbumin upstream promoter-transcription factor)(I、II)、Ear-2(英语:V-erbA-related gene)、HNF4(英语: ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ... GATA(英语:GATA transcription factor)(1、2、3、4、5、6) · MTA(1、2、3) · TRPS1(英语:Tricho-rhino-phalangeal syndrome Type
... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally ... referred to as transcription coregulators) that facilitate or inhibit the transcription of the associated target gene into mRNA ...
"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase ...
Applied analysts make great use of the psychobiography, while academics tend to analyze transcriptions in search of traits and ... Relate personality to key issues, emphasizing in which direction the psychological factors point. Estimate drives, values, and ... when most leaders of coups emerge), or in old age, when leaders, especially narcissists, feel the reins of power slipping and ... and cognitive factors. The important thing to note about leadership analysis is the consistency of the individual's belief ...
People Power Revolution 1986-1987 Philippine coup attempts 1989 Philippine coup attempt EDSA Revolution of 2001 Attempted coups ... "A Complete Transcription of Majapahit Royal Manuscript of Nagarakertagama". Jejak Nusantara (in Indonesian). Cite error: The ... 2001). "Cultural Landmarks and their Interactions with Economic Factors in the Second Millennium in the Philippines". Kinaadman ...
These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... The decline of the Hawaiian language was accelerated by the coup that overthrew the Hawaiian monarchy and dethroned the ... in making handwritten transcriptions of Hawaiian vowels.[86] The missionaries specifically requested their sponsor in Boston to ...
Handbook of Transcription Factor NF-κB. Boca Raton: CRC. 2006. ISBN 0-8493-2794-6.. ... 第二亚族(COUP-TF(I、II)、Ear-2、HNF4(α、γ)、PNR、RXR(α、β、γ)、Testicular receptor(2、4)、TLX). 第三亚族(甾类激素(英语:Steroid hormone receptor)(雄激素、雌激素 ... ELF(2、4、5) · EGF · ELK(1、3、4) · ERF · ERG · ETS(1、2、SPIB) · ETV(1、4、5、6) · FLI1 · Interferon regulatory factors(1、2、3、4、5、6、7、8 ... 核因子活化B细胞κ轻链增强子(英語:nuclear factor kappa-light-chain-enhancer of activated
transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339-47. PMC ...
Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1-2): 1-14. PMID ... podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 ( ... a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor". ... Coller HA, Forman JJ, Legesse-Miller A (2007). ""Myc'ed Messages": Myc Induces Transcription of E2F1 while Inhibiting Its ...
transcription factor binding. • protein domain specific binding. • RNA polymerase II transcription factor activity, sequence- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • sequence- ... transcription, DNA-templated. • spermatogenesis. • positive regulation of transcription from RNA polymerase II promoter. • ...
... s (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... Sterol regulatory element-binding transcription factor 1. X-ray crystallography of Sterol Regulatory Element Binding Protein 1A ... The precursor has a hairpin orientation in the membrane, so that both the amino-terminal transcription factor domain and the ...
transcription corepressor activity. • transcription factor activity, sequence-specific DNA binding. • transcription coactivator ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • nuclear euchromatin. • ... transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. • chenodeoxycholic acid binding. • ... RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. • bile acid receptor activity ...
Gunkel, Christoph (September 13, 2013). "Öko-Coup aus Ostdeutschland". Der Spiegel (in German). Retrieved 4 September 2015.. ... Another factor that may prolong ozone depletion is the drawdown of nitrogen oxides from above the stratosphere due to changing ... resulting in transcription errors when the DNA replicates. These cancers are relatively mild and rarely fatal, although the ... due to a combination of political factors (continued resistance from the halocarbon industry and a general change in attitude ...
The officials who gained power by succeeding in the imperial examination became a leading factor in the shift from a military- ... out of fear that Emperor Gong would stage a coup to restore his reign.[58] Other members of the Song Imperial Family continued ... Transcriptions. Standard Mandarin. Hanyu Pinyin. Sòng cháo. Gwoyeu Romatzyh. Sonq chaur. Wade-Giles. Sung4 ch'ao2. ...
This unsettled the Kremlin, which orchestrated a coup carried out in 1929 by five young Tuvan graduates of Moscow's Communist ... Then, Tuva was administered as part of Outer Mongolia, and the language difference was a determining factor in Tuva seeking ...
Transcription Factor Classification, A classification of transcription factors based on their DNA-binding domains". BIOBASE ... potfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). potfamilija 3 ( ... Latchman DS (1997). „Transcription factors: an overview". Int. J. Biochem. Cell Biol. 29 (12): 1305-12. PMID 9570129. doi: ... DBD: Transcription factor database Home". Приступљено 2. 3. 2008.. *. Wilson D, Charoensawan V, Kummerfeld SK, Teichmann SA ( ...
... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is ... "Entrez Gene: GATA1 GATA binding protein 1 (globin transcription factor 1)".. *^ a b c Da Costa L, O'Donohue MF, van Dooijeweert ... transcription factor complex. • protein-DNA complex. Biological process. • negative regulation of cell proliferation. • ...
transcription factor activity, RNA polymerase II transcription factor recruiting. • RNA polymerase II transcription factor ... Arabidospsis thaliana MYB family at Database of Arabidopsis Transcription Factors (DATF). This article incorporates text from ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ...
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... negative regulation of sequence-specific DNA binding transcription factor activity. • transcription, DNA-templated. • positive ...
Dardess, John W. (1968), Background Factors in the Rise of the Ming Dynasty, Columbia University.. ... On 7 August 1461, the Chinese general Cao Qin and his Ming troops of Mongol descent staged a coup against the Tianshun Emperor ... Transcriptions. Standard Mandarin. Hanyu Pinyin. Dà Míng Dì Guó. Wade-Giles. Ta Ming Ti Kuo. ... Robinson, David M. (1999), "Politics, Force and Ethnicity in Ming China: Mongols and the Abortive Coup of 1461", Harvard ...
"A phylogenomic analysis of bacterial helix-turn-helix transcription factors.". FEMS Microbiol Rev 33 (2): 411-29. PMID 19076237 ... podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 ( ... "Prokaryotic transcription regulators: more than just the helix-turn-helix motif.". Curr Opin Struct Biol 12 (1): 98-106. PMID ...
transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ... transcription regulatory region DNA binding. Cellular component. • transcription factor complex. • protein complex. • nuclear ... In addition, this transcription factor plays an important role in limb and branchial arch development.[6] In one study, it was ... Shen L, Li XF, Shen AD, Wang Q, Liu CX, Guo YJ, Song ZJ, Li ZZ (July 2010). "Transcription factor HAND2 mutations in sporadic ...
transcription factor complex. • RNA polymerase II transcription factor complex. • Ядерце. • клітинне ядро. • nucleoplasm. • ... 0001204 DNA-binding transcription factor activity. • GO:0001105 transcription coactivator activity. • transcription factor ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... transcription from RNA polymerase II promoter. • cellular response to tumor necrosis factor. • positive regulation of DNA- ...
transcription factor activity, sequence-specific DNA binding. • sequence-specific DNA binding. • transcription factor binding. ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... transcription factor complex. • cytoplasm. • cell nucleus. • nucleoplasm. • transcriptional repressor complex. Biological ... RNA polymerase II repressing transcription factor binding. • protein binding. • recombinase activity. • chromatin binding. • ...
0001204 DNA-binding transcription factor activity. • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • regulation of transcription from RNA polymerase ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ... KLF17, ZNF393, Zfp393, Kruppel-like factor 17, Kruppel like factor 17, ZLF393. ...
... s (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... The precursor has a hairpin orientation in the membrane, so that both the amino-terminal transcription factor domain and the ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...
... , ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ... OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd,[5] bowl, sob[9] and ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence- ...
0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • transcription factor activity, RNA polymerase ... RNA polymerase II transcription factor binding. • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... regulation of transcription, DNA-templated. • cellular response to BMP stimulus. • зсідання крові. • transcription, DNA- ...
0001204 DNA-binding transcription factor activity. • 5'-deoxyribose-5-phosphate lyase activity. • transcription factor binding ... "Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y ... 0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • GO:0001105 transcription coactivator activity ... transcription, DNA-templated. • transcription by RNA polymerase II. • nuclear transport. • GO:0022415 viral process. • base- ...
RNA polymerase II transcription factor binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... negative regulation of sequence-specific DNA binding transcription factor activity. • regulation of transcription, DNA- ... negative regulation of transcription, DNA-templated. • transcription, DNA-templated. • negative regulation of transcription ... Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by ...
... , MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1. ... transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... transcription, DNA-templated. • positive regulation of transcription, DNA-templated. • positive regulation of transcription ... Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[5][6] ...
The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... positive regulation of transcription from RNA polymerase II promoter. • transcription, DNA-templated. • transcription from RNA ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. ... regulation of transcription, DNA-templated. • organ induction. • anterior/posterior pattern specification. • ...
transcription corepressor activity. • metal ion binding. • nucleic acid binding. • RNA polymerase II transcription factor ... DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. ... negative regulation of transcription from RNA polymerase II promoter. • negative regulation of intracellular estrogen receptor ... than normal breast tissue from the same patient and that DC-SCRIPT mRNA expression is an independent prognostic factor for good ...
see also transcription factor/coregulator deficiencies. This article on a gene on the human X chromosome and/or its associated ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • DNA geometric change. • negative regulation of B ...
COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ... humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor ...
GO:0003700 DNA-binding transcription factor activity GO:0003707 steroid hormone receptor activity GO:0004879 nuclear receptor ...
COUP transcription factor 1Imported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,Q32NY6,Q32NY6_MOUSE COUP transcription factor 1 OS=Mus musculus OX=10090 GN=Nr2f1 PE=1 SV=1 ... Transcription, Transcription regulationPROSITE-ProRule annotation. ,p>Information which has been generated by the UniProtKB ... positive regulation of transcription by RNA polymerase II Source: Ensembl. *transcription, DNA-templated Source: UniProtKB- ...
Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... COUP transcription factor 2Add BLAST. 414. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... sp,P43135,COT2_MOUSE COUP transcription factor 2 OS=Mus musculus OX=10090 GN=Nr2f2 PE=1 SV=2 ...
COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a ... COUP Transcription Factors. Subscribe to New Research on COUP Transcription Factors A sub-family of steroid receptor-related ... COUP TF Proteins; Chicken Ovalbumin Upstream Promoter Transcription Factors; Transcription Factors, COUP ...
Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical ... The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and ... Romano, Anna Lisa (2013) Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis ... Next, by generating double compound mutants between COUP-TFI and Pax6, I found that lowering the gene dosage of Pax6 in COUP- ...
NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Product Name:Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Packing: ... Target Protein Name:Bovine COUP transcription factor 2, NR2F2 Alternative Name:NR2F2,Bovine COUP transcription factor 2, NR2F2 ... The microtiter plate provided in Bovine COUP transcription factor 2, NR2F2 ELISA KIT has been pre-coated with an Bovine COUP ...
Mechanism of Action of COUP-Transcription Factors Tsai, Ming-Jer Baylor College of Medicine, Houston, TX, United States ... We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult ... When COUP-TFII is conditionally ablated early, the MM cannot form properly and no kidney is formed. When COUP-TFII is knocked ... The various COUP-TFII deficient mouse models generated here will reveal how COUP-TFII affects kidney development and disease ...
Dividing COUP-TFII+ progenitor cells were localised to ventral CGE as previously described but were also numerous in adjacent ... Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 ... We examined expression of three interneuron precursor transcription factors, alongside other markers, using ... Thus COUP-TFII+ progenitors gave rise to pyramidal cells, but also interneurons which not only migrated posteriorly into the ...
COUP-TFs) are members from. The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the ... The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ... The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from ... Also, we explain the series and id of another low Mr COUP-TF, COUP-TF2. Components and strategies Purification from the COUP- ...
Rabbit recombinant monoclonal COUP TF1 antibody [EPR10841] conjugated to Alexa Fluor® 647. Validated in ICC/IF and tested in ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... Alexa Fluor® 555 Anti-COUP TF1 antibody [EPR10841] (ab211712) *Anti-COUP TF1 antibody [EPR10841] - BSA and Azide free (ab224272 ... Alexa Fluor® 647 Anti-COUP TF1 antibody [EPR10841]. See all COUP TF1 primary antibodies. ...
Rabbit recombinant monoclonal COUP TF1 antibody [EPR10841] conjugated to Alexa Fluor® 488. Validated in ICC/IF and tested in ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 647) (ab210038) *Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 555) (ab211712 ... Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 488). See all COUP TF1 primary antibodies. ...
COUP /EAR ,/li,,/ul,,ul,,ul,,li,1: Chicken ovalbumin upstream promoter-transcription factor I ( COUP-TFI ; NR2F1 ) ,/li,,/ul,,/ ... ul,,ul,,ul,,li,2: Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li, ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ...
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... Alternate Names for COUP-TF I/NR2F1 Antibody. *COUP transcription factor 1 ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ...
The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ...
COUP Transcription Factor II , COUP Transcription Factors , Cloning, Molecular , DNA, Complementary , Genetics , DNA-Binding ... Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells / 中国医学科学杂志(英文版) ... Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Transcription Factors / Transcription, Genetic ...
Transcription factor COUP. ENSMUSP00000034831. ProSitePatterns. PS00031. IPR001628. 40. 66. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 381. 392. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 361. 374. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 314. 326. 1.20e-14. ...
Transcription factor COUP. ENSSARP00000012244. ProSitePatterns. PS00031. IPR001628. 46. 72. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSSARP00000012244. PRINTS. PR01282. IPR003068. 390. 401. 5.10e-05. ... Transcription factor COUP. ENSSARP00000012244. PRINTS. PR01282. IPR003068. 370. 383. 5.10e-05. ... Copyright © 2017 REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies ...
COUP Transcription Factor II * DNA-Binding Proteins * LIM Domain Proteins * MEF2 Transcription Factors ... CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. Although recent studies ... aka COUP-TFII), generating a premature truncation of the protein. This patient also carried a missense variant predicted to be ...
IPR003068 Transcription factor COUP. IPR013088 Zinc finger, NHR/GATA-type. IPR001628 Zinc finger, nuclear hormone receptor-type ...
Transcription factor NR2F2 (also known as chicken ovalbumin upstream promoter transcription factor II, COUP-TFII) plays a key ... 1997). Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr. Rev. 18, 229-240. doi:10.1210 ... 2005). Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435, 98-104. doi: ... 2011). Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. ...
Wang, L. H., Tsai, S. Y., Cook, R. G., Beattie, W. G., Tsai, M. J. and OMalley, B. W. (1989). COUP transcription factor is a ... C) Expression of COUP-TFI and COUP-TFII transcripts in cochleae treated with DAPT. COUP-TFI and COUP-TFII expression was not ... Expression of COUP-TFI and COUP-TFII are unchanged by DAPT treatment. We next determined whether DAPT treatment affected COUP- ... COUP-TFI (chicken ovalbumin upstream promoter transcription factor I; also known as NR2F1) is an ONR proposed to function as a ...
COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe- ... "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207-16. PMC 5952191. PMID ...
Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. . Keio J. Med. 52, 174-181 ( ... A series of transcription factors critical for maintenance of the neural stem cell state have been identified1,2,3, but the ... exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. . Cell ... Combinatorial roles of the nuclear receptor corepressor in transcription and development. . Cell 102, 753-763 (2000) ...
... yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress ... COUP Transcription Factor I / metabolism * Cholesterol / metabolism * Cytoprotection* / radiation effects * Fatty Acids / ... Among the nuclear orphan receptors affected by insufficiency of RANBP2, we identified an isoform of COUP-TFI (Nr2f1) as the ... yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress ...
... chicken OVA upstream promoter-transcription factor 1; HNF-4α, hepatocyte nuclear factor-4α; SHBG, sex hormone-binding globulin ... We have also demonstrated that competition between HNF-4α and COUP-TF1 occurs at this site, with HNF-4α promoting transcription ... Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter. J. Biol. ... Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors. J. ...
COUP-TF. Chicken ovalbumin upstream promoter transcription factor. mCPT I. Muscle carnitine palmitoyl transferase I ... Akazawa H, Komuro I (2003) Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res 92:1079-1088PubMedGoogle ... Sack MN, Disch DL, Rockman HA, Kelly DP (1997) A role for Sp and nuclear receptor transcription factors in a cardiac ... Oka T, Xu J, Molkentin JD (2007) Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev ...
Top Transcription factor binding sites by QIAGEN in the TAOK2 gene promoter:. *COUP ... No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAOK2 Gene ... Transcription Factor. Binding Sites. Gene Targets. GH16J029972. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE CraniofacialAtlas ...
Top Transcription factor binding sites by QIAGEN in the PPP2R1B gene promoter:. *COUP ... No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription ... Transcription Factor. Binding Sites. Gene Targets. GH11J111764. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE CraniofacialAtlas ... Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis. *Decreased viability in ...
Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr. Rev. 1997. 18:229-240. View this ... Notably, four transcription factors were identified among the upregulated genes, namely GATA-3, ABF1, Nrf3, and EAR3. GATA-3 is ... These 20 genes include four transcription factors, namely GATA-3, ABF1, Nrf3, and EAR3, the imprinted gene IPL, the tumor ... Molecular cloning and functional characterization of a new Capncollar family transcription factor Nrf3. J. Biol. Chem. 1999. ...
  • COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein that in humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor. (wikipedia.org)
  • Product Description:Bovine COUP transcription factor 2, NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. (lifescience-market.com)
  • Only those wells that contain Bovine COUP transcription factor 2, NR2F2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (lifescience-market.com)
  • The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm.The concentration of Bovine COUP transcription factor 2, NR2F2 in the samples is then determined by comparing the O.D. of the samples to the standard curve. (lifescience-market.com)
  • Although the majority of these genes are not known to be associated with CDH, one patient with CDH and cardiac anomalies harbored a frameshift mutation in NR2F2 (aka COUP-TFII), generating a premature truncation of the protein. (nih.gov)
  • In the present study, we demonstrate that NR2F2 differentially regulates gene expression of venous versus lymphatic ECs (LECs) and document a novel paradigm whereby NR2F2 homodimers induce a venous EC fate, while heterodimers with the LEC-specific transcription factor PROX1 instruct LEC lineage specification. (biologists.org)
  • The nuclear receptor chicken ovalbumin upstream promoter-transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii / Nr2f2 gene impedes their differentiation. (nih.gov)
  • NR2F2 / COUP2 (ARP1, TFCOUP2, COT2, COUP-TF2) is a member of the nuclear receptor superfamily related to the COUP transcription factor. (activemotif.com)
  • The goals of the existing work were Procyanidin B3 inhibitor to spell it out the proteins that bind towards the COUP response component to create the slower (C2) EMSA complicated, and to discover new members from the COUP-TF family members and determine their function. (biodiversityhotspot.org)
  • To clone and identify the proteins involved in regulating the transcription of hTERT and study the role of genes in both hTERT transcription and telomerase activity. (bvsalud.org)
  • The His-tag COUP-TFII fusion proteins were purified by Ni-NTA chromatography . (bvsalud.org)
  • A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. (aacrjournals.org)
  • Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. (aacrjournals.org)
  • Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic protein that is deleted in breast cancer (DBC1), HSP70, HSP90 and the ubiquitin ligase HYD1. (aacrjournals.org)
  • Collectively, our TAP strategy revealed that COUP-TFI may associate with a number of transcriptional regulatory proteins in HeLa S3 cells as well as other classes of proteins that have not been previously implicated in the regulation of gene expression. (aacrjournals.org)
  • Many of these proteins and COUP-TFI were demonstrated to co-occupy the promoter of retinoic acid-induced 1, a newly identified, COUP-TFI target gene in HeLa S3 cells. (aacrjournals.org)
  • We identified interactions between the cortical hem, rich in Wingless-Int (WNT) proteins and bone morphogenetic proteins (BMPs), and an anterior telencephalic source of fibroblast growth factors (FGFs). (biologists.org)
  • This, in turn, initiates a complex signaling cascade of stress-inducible proteins and transcription factors that serves to return the cell to homeostatic conditions. (biomedcentral.com)
  • 2004) Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. (prolekare.cz)
  • It interacts with several nuclear receptor co-activator proteins to activate transcription. (activemotif.com)
  • 1995). Deletion analysis of the mouse BMP4 promoter in MC3T3E1 cells identified a cis-acting E-box element proximal to the transcriptional start site that is bound by upstream regulatory factor ( USF ), a member of the helix-loop-helix family of regulatory proteins (Ebara et al. (atlasgeneticsoncology.org)
  • Remember, transcription factors can interact with hundreds of different binding sites to regulate hundreds of different proteins. (blogspot.com)
  • Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. (abcam.com)
  • Recombinant protein encompassing a sequence within the center region of human COUP TF1. (novusbio.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Even though the -67/-34 bp region contains an imperfect nuclear receptor element, COUP-TFII-mediated activation of the Amhr2 promoter requires a GC-rich sequence at -39 bp known to bind the specificity protein (SP)1 transcription factor. (nih.gov)
  • COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. (wikipedia.org)
  • Terminal differentiation is characterized by the induction of metabolic genes, many of which are the direct targets of the transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and C/CAAT-binding protein (C/EBP) α and β ( 8 - 14 ). (pnas.org)
  • Zinc finger protein 423 (Zfp423) is a critical preadipocyte factor upstream of PPARγ that is not present in non-adipogenic fibroblasts ( 17 ). (pnas.org)
  • Here, we identified a function of nuclear receptors in ALT telomere maintenance that involves a direct interaction between COUP-TFII/TR4 and FANCD2, the key protein in the Fanconi anemia (FA) DNA repair pathway. (sciencemag.org)
  • A glucose sensitive regulator of insulin transcription includes a glucose response element (GIRE) of a liver-pyruvate (L-PK) gent promoter, and an insulin-sensitive element of an insulin-like growth factor binding protein-1 (IGFBP-1) basal promoter. (google.com)
  • b) an insulin-sensitive element of an insulin-like growth factor binding protein-1 (IGFBP-1) basal promoter. (google.com)
  • said glucose response element is inserted upstream of said insulin-sensitive element in an insulin-like growth factor binding protein-1 (IGFBP-1) basal promoter. (google.com)
  • We've shown that the E1A-12 protein mediates this effect by altering the binding of two transcription factors (NF-kB and COUP-TF) to the class I enhancer which, in turn, blocks transcription from the class I promoter. (upenn.edu)
  • The E1A-5 protein of adenovirus contains a 46 amino acid transactivating domain that stimulates promoters by serving as a bridge between the basal transcription complex and upstream factor binding sites. (upenn.edu)
  • A zinc finger within the transactivating domain binds to the TATA box binding protein (TBP) and a newly discovered cellular factor, hSur-2 (a subunit of human mediator complex), while residues flanking the zinc finger associate with other basal transcription factors, referred to as TAFs. (upenn.edu)
  • Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice have demonstrated the importance of this transcription factor for the formation of the epidermal permeability barrier. (elsevier.com)
  • Bollag, WB 2013, ' COUP-TF-interacting protein-2 (Ctip2): Driving the coupé of sphingolipid biosynthesis in the epidermis ', Journal of Investigative Dermatology , vol. 133, no. 3, pp. 593-594. (elsevier.com)
  • The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. (biodiversityhotspot.org)
  • 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al. (biodiversityhotspot.org)
  • The full cDNA of COUP-TFII was cloned from HeLa cDNA library by hTERT promoter-based yeast one- hybrid assay and then in-frame inserted into His-tag fusion expression vector pEK318. (bvsalud.org)
  • The interaction of COUP-TFII with hTERT promoter in vitro was identified by electrophoretic mobility shift assay and Footprint. (bvsalud.org)
  • COUP-TFII could firmly bind to the downstream E-box and the other two binding sites in hTERT promoter. (bvsalud.org)
  • Luciferase reporter assay indicated COUP-TFII could suppress hTERT promoter activity and stable introduction of COUP-TFII into HeLa cells also decreased both endogenous hTERT transcription and telomerase activity. (bvsalud.org)
  • The human COUP-TFII can firmly bind to hTERT promoter, and inhibit telomerase activity through decreasing hTERT transcription. (bvsalud.org)
  • This occurred via a downregulation of hepatocyte nuclear factor-4α (HNF-4α) and replacement of HNF-4α by the chicken OVA upstream promoter-transcription factor 1 at a cis -element within the human SHBG promoter, coincident with repression of its transcriptional activity. (jci.org)
  • The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells. (nih.gov)
  • Consistent with this, COUP-TFII directly activates a -1486 bp fragment of the mouse Amhr2 promoter in transient transfection assays. (nih.gov)
  • Chromatin immunoprecipitation assay confirmed COUP-TFII recruitment to the proximal Amhr2 promoter whereas DNA precipitation assay revealed that COUP-TFII associates with the -67/-34 bp region in vitro . (nih.gov)
  • COUP-TFII transcriptionally cooperates with SP1 on the Amhr2 promoter. (nih.gov)
  • Mutations that altered the GCGGGGCGG sequence at -39 bp abolished COUP-TFII-mediated activation, COUP-TFII/SP1 cooperation, and reduced COUP-TFII binding to the proximal Amhr2 promoter. (nih.gov)
  • Our data provide a better understanding of the mechanism of COUP-TFII action in Leydig cells through the identification and regulation of the Amhr2 promoter as a novel target. (nih.gov)
  • B) COUP-TFII activates the mouse Amhr2 promoter in MA-10 Leydig cells. (nih.gov)
  • MA-10 Leydig cells were cotransfected with either 100 ng of an empty expression vector (control, open bars) or an expression vector for COUP-TFII (filled bars), along with 400 ng of Amhr2 promoter construct (−1486/+77 bp or −34/+77 bp, as indicated). (nih.gov)
  • Here we show that unc-55 encodes a member of the nuclear hormone receptor gene family that is similar to the vertebrate chicken ovalbumin upstream promoter transcription factors. (jneurosci.org)
  • To determine how the promoter is involved in brain-specific transcription of the aromatase gene, we first detected the in vivo occupancy of the aro-AII site by ARP-1 using chromatin immunoprecipitation assays. (frontiersin.org)
  • Transcription of the aromatase gene is governed by multiple tissue-specific promoter regions. (frontiersin.org)
  • Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. (sciencemag.org)
  • Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. (aacrjournals.org)
  • A gene on chromosome 5q14 that encodes a transcription factor that binds to the ovalbumin promoter and, in conjunction with S300-II, stimulates initiation of transcription. (thefreedictionary.com)
  • As a prototype for our analysis, we investigated the expression patterns of chicken ovalbumin upstream promoter transcription factor (COUP-TF) -I and -II in more details during embryonic development and in the adult by immunohistochemistry. (nih.gov)
  • Chicken ovalbumin upstream promoter-transcription factor (COUP-TF), DAX-1, and steroidogenic factor-1 (SF-1) are orphan members of the nuclear hormone receptor superfamily. (elsevier.com)
  • Here, we challenge the in vivo function of the nuclear receptor COUP-TFI (chicken ovalbumin upstream promoter transcription factor 1) in controlling the hippocampal, anatomical, and functional properties along its longitudinal axis. (ovid.com)
  • The receptor transactivation domain is responsible for interaction at the promoter with co-activators such as acetyltransferases and the general transcription machinery, resulting in transcriptional activation. (cellsignal.com)
  • 1996). Mouse BMP4 is negatively regulated by direct binding of chicken ovalbumin upstream-transcription factor I (COUP-TF1) to the proximal promoter of exon I (Feng et al. (atlasgeneticsoncology.org)
  • Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. (elsevier.com)
  • Overall, these data strongly suggest a molecular cross-regulation between COUP-TFI and Pax6 during the maintenance of a proper balance between the stem/ progenitor and committed precursor pools, most probably acting on similar target genes. (unina.it)
  • Preliminary results suggest that COUP-TFII regulates the expression of Angiopoietin 1, WT1, PKD1, TGF and many inflammatory genes, raising the possibility that COUP-TFII functions to protect the kidney from fibrosis, inflammation and from diabetic complications. (grantome.com)
  • Discover related pathways, diseases and genes to COUP-TF I/NR2F1. (novusbio.com)
  • In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. (semanticscholar.org)
  • Genome-wide strategies identify downstream target genes of chick connective tissue-associated transcription factors. (semanticscholar.org)
  • Here we report that the transcriptional repressor transcription factor 7-like 1 (TCF7L1) binds and directly regulates the expression of cell structure genes. (pnas.org)
  • The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. (embl.de)
  • These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. (embl.de)
  • Both genes code for transcription factors which operate by controlling a cascade of other genes hinting at a possible role for COUP-TF1 in area patterning as well. (bio-medicine.org)
  • The phenomenon of stage-specific transcription of globin genes is referred to as globin gene switching. (springer.com)
  • Mechanisms of expression switching, stage-specific activation, and repression of transcription of α- and β-globin genes are of interest from both theoretical and practical points of view. (springer.com)
  • COUP-TF and DAX-1 have been shown to negatively regulate the transcriptional activity of SF-1, a steroidogenic cell-specific activator of various steroidogenic cytochrome P450 genes. (elsevier.com)
  • The nuclear receptor and ligand complexes can then bind directly to DNA and activate the transcription of genes involved in a broad spectrum of physiological processes, ranging from development and differentiation to metabolism ( 1 ). (sciencemag.org)
  • For arterial specification, vascular endothelial growth factor (VEGF) induces expression of Notch signaling genes, including Notch1 and its ligand, Delta-like 4 (Dll4), and Foxc1 and Foxc2 transcription factors directly regulate Dll4 expression. (edu.au)
  • On the other hand, the orphan nuclear receptor COUP-TFII is a determinant factor for venous specification by inhibiting expression of arterial specific genes, including Nrp1 and Notch. (edu.au)
  • Our results provide evidence for the existence of a potent enhancer module, 8 kb distal to the transcription start point, which mediates the transcriptional induction of CYP3A4 by activators of hPXR. (aspetjournals.org)
  • T reg cell transcriptional program is dependent on the transcription factor (TF) Foxp3, which is also essential for their development and suppression function ( 1 - 3 ). (sciencemag.org)
  • By analysing the vein-to-artery cell fate switch at single-cell resolution, they reveal two unexpected features: first, that the vein-to-artery conversion is gradual and overlapping until a transcriptional threshold is reached forming pre-specified artery cells and second, that this arterial pre-specification threshold is actively inhibited by cell cycle activation induced by the vein-specifying transcription factor COUP-TF2. (natureasia.com)
  • Transcription factor predominantly involved in transcriptional repression. (antikoerper-online.de)
  • ARP-1 is a member of the nuclear receptor superfamily and functions as an orphan-type transcription factor. (frontiersin.org)
  • COUP-TFI is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. (nursa.org)
  • The nuclear receptor superfamily are ligand-activated transcription factors that play diverse roles in cell di erentiation/development, proliferation, and metabolism and are associated with numerous pathologies such as cancer, cardiovascular disease, infl ammation, and reproductive abnormalities. (cellsignal.com)
  • Western Blot: COUP-TF I/NR2F1 Antibody [NBP2-15974] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. (novusbio.com)
  • We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult organ function, plays a role in kidney development, function and disease. (grantome.com)
  • The orphan nuclear receptor COUP-TFI (Nr2f1) regulates many aspects of mammalian development, but little is known about its role in cochlear hair cell and Deiter's support cell development. (biologists.org)
  • COUP-TFII regulates mouse Amhr2 gene transcription in MA-10 Leydig cells. (nih.gov)
  • Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
  • Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
  • ERK5 regulates muscle cell fusion through Klf transcription factors. (semanticscholar.org)
  • Thus, our findings reveal that COUP-TFII/TR4 regulates ALT telomere maintenance through a novel noncanonical FANCD2 pathway. (sciencemag.org)
  • TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. (sciencemag.org)
  • Here we review recent advances in understanding how glucose regulates gene transcription in mammals. (physiology.org)
  • The formidable challenge of unravelling the molecular complexity of AEC, VEC and LEC differentiation is further enhanced by the notion that several factors are commonly expressed amongst EC subtypes. (biologists.org)
  • Because loss-of-function studies of Notch signaling components have similar phenotypes, we investigated Notch regulation of hair cell differentiation in COUP-TFI -/- mice and confirmed misregulation of Notch signaling components, including Jag1, Hes5 and in a manner consistent with reduced Notch signaling, and correlated with increases in hair cell and support cell differentiation. (biologists.org)
  • Importantly, inhibition of Notch activity resulted in a greater increase in hair cell differentiation in COUP-TFI -/- cochlear cultures than in wild-type cultures, suggesting a hypersensitivity to Notch inactivation in COUP-TFI -/- cochlea, particularly at the apical turn. (biologists.org)
  • Thus, we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI -/- mice, and suggest that COUP-TFI is required for Notch regulation of hair cell and support cell differentiation. (biologists.org)
  • In the present work, we report that COUP-TFII is an essential regulator of the gene encoding the anti-Müllerian hormone receptor type 2 ( Amhr2 ), which participates in Leydig cell differentiation and steroidogenesis. (nih.gov)
  • Depletion of TCF7L1 inhibits differentiation, because TCF7L1 indirectly induces the adipogenic transcription factor peroxisome proliferator-activated receptor γ in a manner that can be replaced by inhibition of myosin II activity. (pnas.org)
  • We find that the transcription factor Ctip2 (also known as Bcl11b ) is central to MSN differentiation and striatal development. (jneurosci.org)
  • In contrast, less is known about the transcription factor codes that regulate MSN differentiation and patch-matrix development after the progenitor stage. (jneurosci.org)
  • Bagheri-Yarmand R , Vadlamudi RK, Kumar R. Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. (thyroid.org)
  • Thus, during brain formation, the regulation of cell number and the precise timing of differentiation require the interplay between intrinsic programs of development and extrinsic factors. (frontiersin.org)
  • GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. (ucsf.edu)
  • Endothelial cell differentiation depends on communication between the surrounding tissues, which is mediated by growth and differentiation factors able to activate specific gene expression programs. (ahajournals.org)
  • This further level of endothelial cell specialization is induced by the crosstalk with the cells of the surrounding tissues that produce growth and differentiation factors able to activate specific gene expression programs in endothelial cells (see Figure 1 ). (ahajournals.org)
  • All of these steps of endothelial differentiation are regulated by sets of transcription factors, which, in the figure, are listed in boxes corresponding to specific types of vessels. (ahajournals.org)
  • All the steps of endothelial cell differentiation are orchestrated by specific transcription factors ( Figure 1 ). (ahajournals.org)
  • However, very little is known about the transcription factors that induce organ-specific differentiation of the endothelium. (ahajournals.org)
  • For instance, Foxg1 is required constitutively to repress the Cajal-Retzius fate in deep-layer neurons ( 10 ), and COUP-TF1 and Tbr1 are each required for subplate neuron differentiation ( 11 ). (pnas.org)
  • Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
  • TRA16 overexpression was significantly associated with TNM stage, tumor size, lymph node metastasis, tumor thrombus in vein, tumor differentiation and prognosis of NSCLC patients, in which TRA16 was shown to be an independent prognostic factor. (spandidos-publications.com)
  • In the differentiation of neurons and glia in the developing Drosophila eye, we found that the proper intensity of RTK signaling downstream of fibroblast growth factor receptor (FGFR) or epidermal growth factor receptor required two mutually antagonistic feedback loops. (sciencemag.org)
  • Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. (hindawi.com)
  • To further define the defects of COUP-TFII mutants and dissect the underlying mechanism of COUP-TFII action, our specific aims in the next five years are: 1) Delineate the role of COUP-TFII in kidney development and its underlying mechanism;2) Determine the role of COUP-TFII in kidney function and diseases;and 3) Determine the role of COUP-TFII in diabetic nephropathy. (grantome.com)
  • The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ovalbumin gene (Sagami et al. (biodiversityhotspot.org)
  • 1987). An connection between COUP-TF and the S300-II element was shown in electro-phoretic mobility shift assays (EMSAs) by Tsai et al. (biodiversityhotspot.org)
  • The expression of the Prospero homeodomain transcription factor (Prox1) in a subset of cardinal venous cells specifies the lymphatic lineage in mice. (plos.org)
  • After arterial and venous endothelial cells differentiate, a subpopulation of venous endothelial cells is thought to become competent to acquire lymphatic endothelial cell fate by progressively expressing the transcription factors Sox18 and Prox1 to differentiate into lymphatic endothelial cells. (edu.au)
  • Notch, COUP-TFII, and Prox1), While some factors specifically regulate lymphatic (Prox1), vein (COUP-TFII), or artery formation (Hey1/2), other vascular signaling pathways show overlapping activities (e.g. (biomedcentral.com)
  • in both cases COUP-TFII was co-expressed with PAX6 in proliferative zones and TBR1 or calretinin in post-mitotic cortical neurons. (ncl.ac.uk)
  • Oxidative stress is a deleterious stressor associated with a plethora of disease and aging manifestations, including neurodegenerative disorders, yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress are known. (nih.gov)
  • Several transcription factors have been shown to regulate the development of patch and/or matrix neurons by acting on the progenitors of MSN. (jneurosci.org)
  • Generation of pure GABAergic neurons by transcription factor programming. (ucsf.edu)
  • In previous studies, the OLeary lab discovered that Emx2, a gene common to mice and men as is COUP-TF1, instructs progenitor cells to develop into visual neurons. (bio-medicine.org)
  • So OLeary and his team collaborated with Italian researchers, led by Dr. Michele Studer, who is co-senior author with OLeary of the study, to develop mice in which COUP-TF1 can be selectively removed from progenitor cells in the cortex just before they start generating cortical neurons. (bio-medicine.org)
  • While Emx2 works in a positive manner to specify the area identity of visual neurons, the presence of COUP-TF1 prevents progenitor cells from taking on a motor area identity. (bio-medicine.org)
  • In the first part of my work, I found that in the absence of COUP-TFI function cortical cells abnormally proliferate over time, implying that COUP-TFI is responsible for maintaining a proper progenitor pool during development. (unina.it)
  • Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. (ncl.ac.uk)
  • The factor, COUP-TF1, ensures that the frontal areas dont claim too much cortical real estate. (bio-medicine.org)
  • Loss of cortical COUP-TFI function results in a dysmorphic HP with altered shape, volume, and connectivity, particularly in its dorsal and intermediate regions. (ovid.com)
  • COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. (wikipedia.org)
  • Among the nuclear orphan receptors affected by insufficiency of RANBP2, we identified an isoform of COUP-TFI (Nr2f1) as the only receptor stably co-associating in vivo with RANBP2 and distinct isoforms of UBC9. (nih.gov)
  • Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. (aacrjournals.org)
  • It was reported that nuclear receptors COUP-TFII and TR4 are recruited to the enriched GGGTCA variant repeats embedded within ALT telomeres, implicating nuclear receptors in regulating ALT activity. (sciencemag.org)
  • Transcription factors 3: nuclear receptors. (embl.de)
  • In addition to COUP-TFs, we also examined the expression profiles of eight other nuclear receptors (farnesoid X receptor, vitamin D receptor, hepatocyte nuclear factor 4alpha, retinoid X receptor alpha, mineralocorticoid receptor, steroidogenic factor 1, liver receptor homolog-1, and germ cell nuclear factor). (nih.gov)
  • In summary, the results indicate that co-localization of COUP-TF, DAX-1, and SF-1 in NL was lost in adrenocortical tumors and that these orphan receptors play an important role in the regulation of steroidogenesis in human adrenals. (elsevier.com)
  • Most of these receptors regulate transcription by binding to their target DNA elements either as monomers or homodimers and recruiting chromatin modifying coactivators and the transcription machinery. (cellsignal.com)
  • In addition, a variety of transcription factor families acting downstream of-or in concert with-these signaling networks play vital roles in arteriovenous (AV) specification. (edu.au)
  • CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. (nih.gov)
  • Completely eliminating the gene in lab mice through genetic engineering a mainstay of scientists trying to figure out the function of a particular gene did not clarify the roles of COUP-TF1. (bio-medicine.org)
  • In a genetic screen for factors that promoted Rb mutant cell death in Drosophila , we identified Psid, a regulatory subunit of N-terminal acetyltransferase B (NatB). (prolekare.cz)
  • 3 Consequently, researchers must attempt to tease out what must be a dynamic interplay among heterogeneous genetic backgrounds, diverse environmental factors, and differential etiologies in the pathogenesis of this disorder, all of which make attempts to understand the genetic basis of hypertension a challenge. (ahajournals.org)
  • Whereas some of the disagreement among reports must arise from the factors discussed above (ie, genetic, etiologic, and environmental heterogeneity), a substantial proportion may be because of poorly defined inclusion criteria or inadequate appreciation of the importance of statistical power and replication. (ahajournals.org)
  • Regulation of the apolipoprotein A-I gene transcription. (uniprot.org)
  • The orchestration of these processes for different cell types requires the tight regulation of both intrinsic and extrinsic factors. (frontiersin.org)
  • Bolte C, Ren X, Tomley T et al (2015) Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development. (springer.com)
  • The orphan receptor TR3 (also known as nur77 or nerve growth factor-induced clone B NGFI-B) ( 1-3 ) functions as a nuclear transcription factor in the regulation of target gene expression ( 4-7 ). (sciencemag.org)
  • see below), an important transcription factor in the regulation of the fatty acid synthase ( FAS ) gene, is independent of external glucose. (physiology.org)
  • Most strikingly, Ctip2 , a transcription factor required for the formation of the corticospinal tract, was not expressed in the Fezl -deficient cortex. (pnas.org)
  • Human Developmental Biology Resource (HDBR) » The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon. (hdbr.org)
  • Furthermore, adult mice with the loss of one COUP-TFII allele display polycystic kidneys, glomerulosclerosis (FSGS) and loss of kidney function, phenotypes resembling human kidney diseases. (grantome.com)
  • Abnormal signaling centers were further investigated in mice lacking the transcription factor EMX2, in which FGF8 activity is increased, WNT expression reduced, and the hippocampus defective. (biologists.org)
  • Mice without COUP-TF1 have many defects and die a few days after birth before functional areas can be defined, explains co-first author Shen-Ju Chou, a postdoctoral researcher in the OLeary lab. (bio-medicine.org)
  • Although the mice lacking COUP-TF1 in their cortex do not have any obvious sensory or motor problems, the researchers believe that a closer look will reveal substantial deficits. (bio-medicine.org)
  • Recent efforts have focused on identifying committed preadipocyte populations in vivo ( 15 , 16 ), as well as on determining molecular factors that define the committed preadipocytes phenotype. (pnas.org)
  • Moreover, recent studies demonstrated mutual inhibition between PXR and nuclear factor (NF)-κB signaling pathway, providing a potential molecular mechanism that links xenobiotic metabolism and inflammation [ 10 , 11 ]. (mdpi.com)
  • 2010). In retinal pigment epithelium cells of patients suffering from the wet form, but not the dry form, of macular degeneration, TNFalpha represses BMP4 transcription through phosphorylation of the transcription factor Sp1, demonstrating a BMP4 expression-dependent molecular switch (Xu et al. (atlasgeneticsoncology.org)
  • Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development. (elsevier.com)
  • Our hypothesis was that we would identify differentially expressed transcription factors, coregulators and chromatin-modifying enzymes. (biomedcentral.com)
  • In addition, the repressor COUP-TF becomes strongly bound to a different recognition site on the class I enhancer, where it associates with a histone deacetylase (HDAC) and E1A-12, resulting in chromatin compaction. (upenn.edu)
  • 1 h) chromatin remodeling and recruitment of a first transcription factor, HNF‐3. (embopress.org)
  • Upon demethylation, two additional transcription factors are recruited when chromatin is remodeled. (embopress.org)
  • Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). (jove.com)
  • These include the Hedgehog, Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-β (TGF-β), Wnt and Notch signaling pathways. (edu.au)
  • These include Notch and Notch-regulated transcription factors (e.g. (edu.au)
  • Aitola M, Carlsson P, Mahlapuu M, Enerback S, Pelto-Huikko M (2000) Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions. (springer.com)
  • At the nephrongenesis stage (E13.5), COUP-TFII becomes regionalized with high expression in the distal tubules and the glomeruli (podocytes and Bowman's capsule), but not detected in the proximal tubules. (grantome.com)
  • We examined expression of three interneuron precursor transcription factors, alongside other markers, using immunohistochemistry on 8-12 post-conceptional weeks (PCW) human telencephalon sections. (ncl.ac.uk)
  • NKX2.1, OLIG2 and COUP-TFII expression occupied distinct (although overlapping) neurogenic domains which extended into the cortex and revealed three CGE compartments: lateral, medial and ventral. (ncl.ac.uk)
  • A) Depletion of COUP-TFII in MA-10 Leydig cells reduces Amhr2 gene expression. (nih.gov)
  • We showed that COUP-TFI is expressed in the stroma and mesenchymal cells at embryonic d 11.5 (E11.5) and expression persists throughout embryonic development. (nih.gov)
  • In the adult kidney, only mesangial cells show meaningful COUP-TFI expression. (nih.gov)
  • In contrast, COUP-TFII expression is detected as early as E9.5 and high expression is seen in the mesenchymal-derived epithelial cells but not in the ureteric buds through E12.5. (nih.gov)
  • At E13.5, COUP-TFII expression becomes regionalized with higher expression in the region that gives rise to the distal tubule. (nih.gov)
  • The proximal part of the S-shaped body that will become the glomerulus after endothelial cell migration shows COUP-TFII expression in podocyte precursor cells and epithelial cells of the Bowman's capsule. (nih.gov)
  • We therefore examined the expression levels and immunolocalization of COUP-TF, DAX-1, and SF-1 in human adrenal gland (NL) and adrenocortical adenomas, and compared the results with CYP17 expression levels and its enzyme activities to study their potential correlation with adrenocortical steroidogenesis. (elsevier.com)
  • These results showed CYP17 expression to be upregulated and downregulated in CS and DOC, respectively, in a manner reciprocal to that of its repressors, COUP-TF and/or DAX-1. (elsevier.com)
  • Here, we identify that retinoic acid (RA) signaling directly promotes the expression of the transcription factor Nr2f1a within the anterior lateral plate mesoderm. (zfin.org)
  • Further, the expression of sprouty was repressed and that of rau was increased by the COUP transcription factor Seven-up in the presence of weak, but not constitutive, activation of FGFR. (sciencemag.org)
  • Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV (2011) Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. (springer.com)
  • 2008). Furthermore, the transcription factor Cdx2 has been shown to directly regulate BMP4 expression in mouse trophoblast cells to promote early mouse embryogenesis (Murohashi et al. (atlasgeneticsoncology.org)
  • Other diverse signals, such as membrane depolarization and nerve growth factor, also increase TR3 expression ( 3 , 11 ). (sciencemag.org)
  • BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. (elsevier.com)
  • Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. (elsevier.com)
  • 16. Moon NS, Di Stefano L, Dyson N (2006) A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. (prolekare.cz)
  • Disruption of the cell cycle required the ability of AML-1-ETO to repress transcription because a mutant of AML-1-ETO, Δ469, which removes the majority of the corepressor binding sites, had no phenotype. (asm.org)
  • The COUP-TFII/TR4-FANCD2 complex actively induces the DNA damage response by recruiting endonuclease MUS81 and promoting the loading of the PCNA-POLD3 replication complex in ALT telomeres. (sciencemag.org)
  • Through the characterization of COUP-TF, the heterogeneity from the substances became obvious. (biodiversityhotspot.org)
  • PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. (jove.com)
  • In addition, excess proliferation in the COUP-TFI -/- sensory epithelium indicates that the origin of the extra HCs in the apex is complex. (biologists.org)
  • Birdsey GM, Shah AV, Dufton N et al (2015) The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling. (springer.com)
  • When COUP-TFII is knocked out at a later stage, very few nephrons are apparent and there is no detectable distal tubule, suggesting that COUP-TFII is critical for the formation and patterning of the nephron. (grantome.com)
  • In the adult mouse kidney, COUP-TFII is detected in distal tubules, podocytes, and the epithelial cells of the Bowman's capsule. (nih.gov)
  • 1989). Antisera and labeled concatenated COUP elements were used to display a HeLa cell mRNA library in lambda gtll and determine a COUP-TF1 cDNA (Wang et al. (biodiversityhotspot.org)
  • 1989). Therefore, COUPTF1, defined as a transcription aspect originally, Procyanidin B3 inhibitor joined up with the steroid/thyroid hormone receptor superfamily. (biodiversityhotspot.org)
  • 1989). Great and low Mr COUP-TFs had been separated by Superose 12 FPLC (Pharmacia) in buffer filled with 20 mM HEPES, pH 7.9, 100 mM KCl, 10% (v/v) glycerol, 5 mM MgCl2, and 2 mM dithiothreitol. (biodiversityhotspot.org)
  • Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and O'Malley BW (1989) COUP transcription factor is a member of the steroid receptor superfamily. (nursa.org)
  • For example, in the developing spinal cord, neuronal fates are defined by unique combinations of transcription factors (TFs) ( 8 , 9 ). (pnas.org)
  • The formation of each vessel type is regulated by different combinations of transcription factors (e.g. (biomedcentral.com)
  • The identification of factors that define adipocyte precursor potential has important implications for obesity. (pnas.org)
  • However, Zfp423 also has been identified as a regulator of neurologic development ( 18 ), suggesting that other factors also may be involved in specifying adipogenic competency and commitment of precursor cells upstream of PPARγ. (pnas.org)
  • The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. (elifesciences.org)