COUP Transcription Factor II
COUP Transcription Factors
COUP Transcription Factor I
Transcription Factors
Insulin-Like Growth Factor II
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
Transcription, Genetic
Scleroderma, Localized
Promoter Regions, Genetic
DNA-Binding Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Base Sequence
The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. (1/142)
The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development. (+info)Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/142)
Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling. (+info)Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter. (3/142)
Seven mutations in the hepatocyte nuclear factor (HNF)-4alpha gene have been shown to correlate with type 1 maturity-onset diabetes of the young (MODY 1), a monogenic form of type 2 diabetes. Up to now, only the functional properties of two MODY 1 HNF-4alpha mutants, Q268X and V393I, have been investigated to address how the mutations in the HNF-4alpha gene, found by genetic studies, can give rise to impaired activities of mutated HNF-4alpha proteins and can cause this disease. The E276Q mutation results in a nonconservative substitution occurring in the HNF-4alpha E domain, which is involved in dimerization and transactivation activities as well as in protein-protein interactions with other transcription factors or coactivators. Using the mutated human HNF-4alpha2, we have found that, in the absence of chicken ovalbumin upstream promoter transcription factor II (COUP TFII), the E276Q substitution does not significantly affect the dimerization and transactivating activities of HNF-4alpha, at least on the promoters studied herein. On the other hand, in the presence of COUP TFII, the substitution impairs the enhancement of HNF-4-mediated activation of HNF-1 promoter. The impaired synergy between COUP TFII and HNF-4 on the HNF-1 promoter results from an alteration of their interaction. HNF-1 expression plays a crucial role in transactivation of insulin promoter and of numerous genes coding for enzymes involved in glucose homeostasis. Therefore, its downregulation resulting from the E276Q mutation in HNF-4alpha gene most probably impairs the function of pancreatic beta-cells. (+info)Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. (4/142)
Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase CYP26. Subsequently in the embryonic retina, CYP26 forms a narrow horizontal boundary between the dorsal and ventral dehydrogenases, creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal and ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns. (+info)Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response. (5/142)
Transcription of the L-type pyruvate kinase (L-PK) gene is induced by glucose in the presence of insulin and repressed by glucagon via cyclic AMP. The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs). From ex vivo and in vivo experiments, it appears that USFs are required for correct response of the L-PK gene to glucose, but their expression and binding activity are not known to be regulated by glucose. A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i.e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). Binding of COUP-TFII to the GlRE was confirmed by electrophoretic mobility shift assays, and COUP-TFII-containing complexes were detectable in liver nuclear extracts. Neither abundance nor binding activity of COUP-TFII appeared to be significantly regulated by diets. In footprinting experiments, two COUP-TFII-binding sites overlapping the E boxes were detected. Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. In addition, a mutated GlRE with increased affinity for USF and very low affinity for COUP-TFII conferred a dramatically decreased glucose responsiveness on the L-PK promoter in hepatocytes in primary culture by increasing activity of the reporter gene in low glucose condition. We propose that COUP-TFII could be a negative regulatory component of the glucose sensor complex assembled on the GlRE of the L-PK gene and most likely of other glucose-responsive genes as well. (+info)Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (6/142)
The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription. (+info)HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). (7/142)
The gene for cholesterol 7alpha-hydroxylase (CYP7A1) contains a sequence at nt -149 to -118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) synergistically activate transcription of the CYP7A1 promoter. Transactivation of CYP7A1 by HNF4 in the human hepatoma cell line, HepG2, was enhanced by cotransfection with COUP-TFII or the basal transcription element binding protein (BTEB). HNF4 prepared from rat liver nuclear extracts bound to oligomers homologous to the nt -146 to -134 sequences in electrophoretic mobility shift assays (EMSA), which corresponded to a conserved region containing a direct repeat of hormone response elements spaced by one nucleotide (DR1). The sequences surrounding this DR1 were found to be essential for the HNF4 transactivation. In vitro-translated COUP-TFII was found to bind the adjacent sequences from nt -139 to -128 (DR0), but COUP-TFII interacted with this region at a much lower affinity than to the COUP-TFII-site at nt -72 to -57 (DR4). Mutations at nt -139 to -128 or nt -72 to -57 reduced the COUP-TFII and HNF4 synergy; however, these COUP-TFII-binding sequences were not absolutely required for the cooperative effect of HNF4 and COUP-TFII on transactivation. These results indicated that the observed transactivation was the result of protein/protein interactions facilitated by the juxtaposition of the binding elements. (+info)ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. (8/142)
Actin related protein of vertebrate, Arp1, is a major component of the dynactin complex. To characterise and localise Arp1 during mammalian spermatogenesis, polyclonal antibodies were raised against a human recombinant Arp1. Anti-Arp1 antibodies were used for western-immunoblotting, indirect immunofluorescence and immunoelectron microscopy. In round spermatids, Arp1 was detected at the centrosome and at the Golgi apparatus. In elongated spermatids, Arp1 was predominantly found along microtubules of the manchette and at their site of attachment to the nuclear envelope. In maturing spermatids, Arp1 was still present in the pericentriolar material, but in testicular spermatozoa it was not detectable. These various localisations of Arp1 and their changes during spermatid differentiation suggest that the dynactin complex in association with dynein might contribute to several activities: the functional organisation of the centrosome and of the Golgi apparatus and the shaping of the nucleus by manchette microtubules. (+info) Localized scleroderma, also known as morphea, is a type of scleroderma that affects only one area or limb and does not spread throughout the body. It is characterized by the thickening and hardening of the skin, resulting in firm, shiny, and often purple or brown patches. The condition can also cause inflammation and scarring, and may lead to joint contractures and deformities if left untreated.
There are several subtypes of localized scleroderma, including:
* Linear morphea: This is the most common form of localized scleroderma and appears as a linear or polylinear band of hardened skin on the arms, legs, or torso.
* Plaque morphea: This type of scleroderma causes flat, disk-shaped patches of thickened skin that can be red, purple, or brown.
* Guttate morphea: This form of localized scleroderma is characterized by numerous small, drop-like lesions on the arms, legs, or torso.
The exact cause of localized scleroderma is not known, but it is believed to be an autoimmune disorder that triggers the immune system to attack healthy tissue in the skin. The condition can be diagnosed through a combination of physical examination, medical history, and diagnostic tests such as biopsies or imaging studies.
Treatment for localized scleroderma typically involves topical medications, such as corticosteroids or immunosuppressants, to reduce inflammation and slow the progression of the disease. In some cases, phototherapy or physical therapy may also be recommended to improve symptoms and prevent complications.
While there is no cure for localized scleroderma, early diagnosis and appropriate treatment can help manage the condition and improve quality of life for those affected.
Simply put, Facial Hemiatrophy is a condition where one side of the face is smaller than the other due to damage to the facial nerve. This can result in weakness or paralysis of the muscles on that side, causing asymmetry of the face. The condition can be caused by various factors such as trauma, stroke, tumors, and Bell's palsy. Treatment options vary depending on the underlying cause but may include physical therapy, surgery or medication to help regain facial function and symmetry.
COUP-TFI
"Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...
Griffin P. Rodgers
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
COUP-TFII
"Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ...
BCL11B
"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. Research suggests that ... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... Transcription factors, All stub articles, Human chromosome 14 gene stubs). ...
BCL11A
... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11A was initially discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize ... Transcription factors, All stub articles, Human chromosome 2 gene stubs). ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ...
Nucleolin
... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ... It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional ...
Uteroglobin
"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... 2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney". J. Biol. Chem. 276 (16): 13295- ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ... "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis ...
Chicken ovalbumin upstream promoter-transcription factor
COUP+Transcription+Factor+I at the US National Library of Medicine Medical Subject Headings (MeSH) COUP+Transcription+Factor+II ... There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively. ... COUP+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ...
Estrogen receptor alpha
Budhram-Mahadeo V, Parker M, Latchman DS (February 1998). "POU transcription factors Brn-3a and Brn-3b interact with the ... Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types ... July 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ...
Aryl hydrocarbon receptor
Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ... The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ...
Retinoid X receptor alpha
"Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ...
Nuclear receptor 4A1
This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ... The binding sites on the response elements for NR4A1, which are common to the two other members of the NR4A family, are: NBRE ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is ...
Ceramide kinase
... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide-1-phosphate. This enzyme ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ...
V-erbA-related gene
Transcription factors, All stub articles, Human chromosome 19 gene stubs). ... "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...
List of MeSH codes (D12.776)
... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... macrophage-activating factors MeSH D12.776.467.374.480.615.350 - interferon type ii MeSH D12.776.467.374.480.625 - macrophage ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ...
Fibroblast growth factor 8
Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is ... Tanaka S, Ueo H, Mafune K, Mori M, Wands JR, Sugimachi K (May 2001). "A novel isoform of human fibroblast growth factor 8 is ...
List of MeSH codes (D12.776.930)
... coup transcription factor i MeSH D12.776.930.682.074.500 - coup transcription factor ii MeSH D12.776.930.682.350.174 - estrogen ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk transcription factor MeSH D12.776.930.127.656.770 - nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk transcription factor MeSH D12.776.930.316.750.770 - nf-e2 ...
Nuclear receptor
... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... In addition, two additional classes, type III which are a variant of type I, and type IV that bind DNA as monomers have also ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often ...
HDAC1
"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (December 2002). "MBD3 and HDAC1, two components of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ...
Lck
... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... There are two main pools of T cells which mediate adaptive immune responses: CD4+ T cells (or helper T cells), and CD8+ T-cells ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... The two main phosphorylation sites on Lck are tyrosines 394 and 505. The former is an autophosphorylation site and is linked to ...
Blackfoot language
Two series (s, y) were taken from Cree but given different vowel values; three more (p, t, m) were changed in consonant values ... "This is my coup story." A story in the Great Falls Tribune noted, "When the station was replaying programming that originated ... The transcription uses an official, technically accurate alphabet and the authors of this book have classified entries and ... According to the UNESCO Factor 9: Amount and Quality of Documentation, there may be adequate grammar or sufficient amount of ...
Leadership analysis
He is the most expressive post-World War II president and with high adverbial intensifiers, he is an actor who displays ... Applied analysts make great use of the psychobiography, while academics tend to analyze transcriptions in search of traits and ... Relate personality to key issues, emphasizing in which direction the psychological factors point. Estimate drives, values, and ... when most leaders of coups emerge), or in old age, when leaders, especially narcissists, feel the reins of power slipping and ...
Hawaiian language
There are two kinds of Hawaiian-immersion medium schools: K-12 total Hawaiian-immersion schools, and grades 7-12 partial ... These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... in making handwritten transcriptions of Hawaiian vowels. The missionaries specifically requested their sponsor in Boston to ... The decline of the Hawaiian language was accelerated by the coup that overthrew the Hawaiian monarchy and dethroned the ...
Nazism and the Wehrmacht
... politics were not a factor. During World War II, the German military had thousands of its members executed, often for the most ... significantly reducing the coup risk Hitler faced from building an effective army. However, as the successor to a ... Using transcriptions of secret records of conversations among POWs, they conclude that most soldiers were not interested in ... After World War II, a substantial number of the military leaders were called on to testify under oath. Anyone who has studied ...
HM Prison Wormwood Scrubs
Julet Armstrong, protagonist of the 2018 Kate Atkinson World War II novel Transcription, works for MI5 for a time in the Scrubs ... A 2021 inquest subsequently identified the prison's failure to provide food and medication as contributing factors to the death ... Billy Liar The Man In Possession The Spy Who Came in from the Cold The Horse's Mouth Hot Millions Frenzy A Very British Coup ... The prison cell blocks are Grade II listed, with the gatehouse given the higher Grade II* rating. Major structural changes to ...
John Adams
Two, who had fired directly into the crowd, were convicted of manslaughter. Adams was paid a small sum by his clients. ... In 1799, Napoleon took over as head of the French government in the Coup of 18 Brumaire and declared the French Revolution over ... Ferling attributes Adams's defeat to five factors: the stronger organization of the Republicans; Federalist disunity; the ... "Declaration of Independence: A Transcription". United States National Archives. November 2015. Retrieved October 1, 2018. " ...
Macedonian front
The Germans sent two more divisions to help bolster the Bulgarian Army but by 19 November the French and Serbian Army captured ... Another major factor contributed to the Bulgarian request for an armistice. A mass of retreating Bulgarian mutineers had ... transcriptions of primary source documents, listing which units redeployed to Salonika Falls 1933, pp. 31-32, 42-50. Falls 1933 ... With Allied assistance, they launched a coup which secured Thessaloniki and most of Greek Macedonia for Venizelos. From that ...
Judaism and pop and rock music
... bass on two albums) Steely Dan - one of two constant members Donald Fagen (vocals, keyboards) Stephen Malkmus and the Jicks - ... "Interview: Michael Shuman on the 'Feed' soundtrack". Coup De Main. Azerrad, Michael. "THE REAL STORY ABOUT MARK SANDMAN". {{ ... Canarsie was misspelled as "Canarsey" in the transcription. Frydberg, Tracy (July 22, 2012). "Justin tweets tween Madison to ... "Who is Raign? 8 facts about the controversial X Factor 2014 contestant". Metro. 8 September 2014. Retrieved 28 September 2014 ...
Symphony No. 8 (Schubert)
... using the transcription of the first two movements prepared by Hüttenbrenner, his own completion of Schubert's Scherzo, and the ... It could have been a combination of both factors. In 1823, the Graz Music Society gave Schubert an honorary diploma. He felt ... Puech, Benjamin (2019-02-07). "La Symphonie n°8 de Schubert achevée à coups d'intelligence artificielle". Le Figaro (in French ... The following exists: The first two movements, complete in full score The first two pages of a scherzo in full score The rest ...
History of Romania
Others included the II Aurelia Dacorum in Pannonia Superior, the cohort I Aelia Dacorum in Roman Britain, and the II Augusta ... The coup accelerated the Red Army's advance into Romania, but did not avert a rapid Soviet occupation and capture of about ... Recent scholars have argued that he is very likely to be identical to Cotiso, since "Cotiso[n]" is an easy transcription error ... This weapon, more so than any other single factor, forced the Roman army to adopt previously unused or modified equipment to ...
Black power
Transcription by Andrew Pollack for the Encyclopaedia of Trotskyism On-Line. Brown, Scot, Fighting for US: Maulana Karenga, the ... In a Cabinet re-shuffle, he removed three ministers (two of them white) and three senators. However, he also introduced the ... It is often described as an attempted military coup. Williams, who was accused of upholding colonial and capitalist power ... dictating that black Americans create their own identities despite being subjected to pre-existing societal factors. "Black ...
RCA
An RCA Studio II home video game console, introduced in 1977, was canceled just under two years later due to poor sales. RCA's ... He was ousted in a 1975 "boardroom coup" led by Anthony Conrad, who became the new company president. Conrad resigned less than ... "RCA Program Transcription Album Discography (1931-33)". bsnpubs.com. Both Sides Now Publications. Retrieved August 19, 2015. A ... which would be an important factor in helping RCA survive the economic pressures of the Great Depression that began in late ...
Plymouth Colony
Standish led two early military raids on Indian villages: the raid to find and punish Corbitant for his attempted coup, and the ... Note: this reference contains partial transcriptions of Winslow's Mourt's Relations and Bradford's Of Plimoth Plantation, which ... created great hardship for the colonists for many years and was directly cited by William Bradford as a contributing factor to ... After two months at sea, they sighted land on November 9, 1620 off the coast of Cape Cod. They attempted to sail south to the ...
Neo-Assyrian Empire
The two Neo-Assyrian kings generally believed to have been usurpers, Tiglath-Pileser III and Sargon II, did for the most part ... The sole factor for the higher frequency and more vivid descriptions from the Neo-Assyrian Empire is that the Assyrians were ... Through a well-developed network of spies and informants, Esarhaddon uncovered all of these coup attempts and in 670 BC had a ... such as the Rassam cylinder of Ashurbanipal Rassam cylinder transcription in "CDLI-Archival View". cdli.ucla.edu. "The country ...
Stafford Beer
Upon returning to England he was assigned to the Human factors Branch of Operations research at the War Office. In 1949, he was ... Beer had five sons and two daughters, one of whom is Vanilla Beer, an artist and essayist.[citation needed] She exhibited with ... Although Cybersyn was abandoned after Allende's death during the Pinochet coup in 1973, Beer continued to work in the Americas ... "Designing Freedom" The 1973 Massey Lectures RADIO CANADA INTERNATIONAL TRANSCRIPTION: E1121 "The Real Threat to all We Most ...
Delhi Sultanate
Also two huge minarets at Ghazni. Ulugh Khan also known as Almas Beg was brother of Ala-al Din Khalji; his destruction campaign ... This factor also played an important role in the synthesis of cultures. The Hindustani language (Hindi/Urdu) began to emerge in ... Muiz ud-Din Kaiqabad was assassinated and Jalal-ad din took power in a military coup. He was around 70 years old at the time of ... and their chancellery rescripts bore transcriptions in the Devanagari script of the Persian contents. The practice is said to ...
Supreme Court of the United States
What judges have wrought is a coup d'état - slow moving and genteel, but a coup d'état nonetheless. Leiter, Brian (March 19, ... two cases affirmed by an equally divided Court, and two cases were dismissed as improvidently granted. Justice Kagan recused ... CQ Transcriptions (Senator Kohl) (July 14, 2009). "Key Excerpt: Sotomayor on Bush v. Gore". The Washington Post. Archived from ... partisan and sometimes even political factors playing a role. The fear of mental decline and death often motivates justices to ...
Yerevan
... or between two vowels (ebani > avan, Zabaha > Javakhk)....In other words b was placed between two vowels. The true ... The location of Yerevan itself, is an inspiring factor for the foreigners to visit the city in order to enjoy the view of the ... The transcription of the second cuneiform bu [original emphasis] of the word was very essential in our interpretation as it is ... Serzh Sargsyan announced on the Public Television of Armenia that their respective agencies have prevented an attempted coup ...
Spanish Inquisition
The first two inquisitors, Miguel de Morillo and Juan de San Martín, were not named until two years later, on 27 September 1480 ... In addition, the coup that allowed Isabella to take the throne from Joana of Avis and the Catholic Monarchs to marry had ... A literal transcription of the verdict and sentence. If the accused has been accused of more than one thing the sentence ... The use of religion as a unifying factor across a land that was allowed to stay diverse and maintain different laws in other ...
Mary-Claire King
"Expression profiling in primates reveals a rapid evolution of human transcription factors". Nature. 440 (7081): 242-245. ... These two genes, BRCA1 and BRCA2, work to clean up cells in the body that have been harmed by things such as tobacco or just ... Her time there was cut short when the Chilean government of Salvador Allende was overthrown in a CIA-backed military coup on ... King in recent years has developed a deep interest in studying the genetic factors influencing schizophrenia. In collaboration ...
Debate over the atomic bombings of Hiroshima and Nagasaki
It was agreed that psychological factors in the target selection were of great importance. Two aspects of this are (1) ... "United States Strategic Bombing Survey; Summary Report" (Transcription of original work). Report. United States Government ... Once these coup attempts had failed, senior leaders of the air force and Navy ordered bombing and kamikaze raids on the U.S. ... and some regard the bombings as the deciding factor, but others see the bombs as a minor factor, and yet others assess their ...
Majapahit
The great prosperity of Majapahit was probably due to two factors. Firstly, the northeast lowlands of Java were suitable for ... After this coup, the war between Demak and Daha receded, since Raden Patah, Sultan of Demak, left Daha alone like his father ... Javanese Texts in Transcription (3rd (revised) ed.). The Hague: Martinus Nijhoff. Pigeaud, Theodoor Gautier Thomas (1960b). ... and on the wall there are two layers of gates, the palace is very well guarded and clean. The king's palace was a two-storey ...
Philippines
During World War II the Japanese Empire invaded, and the Second Philippine Republic, under Jose P. Laurel, was established as a ... Latitude is an insignificant factor in the variation of temperature while altitude shows greater contrast in temperature. Thus ... However, wealthier families were able to preserve transcriptions of these epics as family heirlooms, particularly in Mindanao. ... and coup attempts. A communist insurgency and a military conflict with Moro separatists persisted, while the administration ...
Historiography of the May Revolution
Those two axis are why it isn't our declared enemy. Read by yourself the notice that has just been published in the British ... No religious factors were involved in the revolution: all the revolutionaries and royalists agreed to support Catholicism. ... The fascist author Hugo Wast would describe the Revolution as a military coup carried out by military leaders, and where the ... as the quotes kept do not come from transcriptions or recordings but from memories wrote years later or from oral tradition. ...
Bangkok
The two main centres are the National Stadium complex, which dates to 1938, and the newer Hua Mak Sports Complex, which was ... Education has long been a prime factor in the centralization of Bangkok and will play a vital role in the government's efforts ... The latest gubernatorial election took place on 22 May 2022 after an extended lapse following the 2014 Thai coup d'état, and ... In contrast to the 169-letter-long transcription provided above in this article, the form recorded in the Guinness World ...
Spread of the Latin script
There were two major exceptions to this "Greek East and Latin West" rule: Illyria, which was annexed as the province of ... It was banned in some places such as Libya after Moammar Gaddafi's 1969 coup, in favour of exclusive Arabic script. Since at ... the crucial factor in Latinising these remaining groups that resisted full integration was granting them Roman citizenship ( ... Kabyle intelligentsia began to stimulate the transition and especially since the establishment of a standard transcription for ...
SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII - PubMed
Here, we examined COUP-TFII as a potential repre … ... COUP Transcription Factor II / metabolism* Actions. * Search in ... SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII Wulin Aerbajinai 1 , Jianqiong ... SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII Wulin Aerbajinai et al. Blood. ... A) Antibodies against COUP-TFII and RNA polymerase II (PoL II) were used to immunoprecipitate chromatin. Precipitated DNA was ...
Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX...
COUP Transcription Factor II / chemistry Actions. * Search in PubMed * Search in MeSH ... In contrast to the mouse, these data establish COUP-TF2 as a human "pro-ovary" and "anti-testis" sex-determining factor in ... encoding COUP-TF2, in three children. One carried a c.103_109delGGCGCCC (p.Gly35Argfs∗75) mutation, while two others carried a ... In two of three children the mutation was de novo. All three children presented with congenital heart disease (CHD), one child ...
Publications - Griffin P. Rodgers, M.D., M.A.C.P. - NIDDK
SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.. Aerbajinai W, Zhu J, ... The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.. Chin KL, Aerbajinai W ... Glia maturation factor-γ mediates neutrophil chemotaxis.. Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.. J Leukoc ... Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo.. Zhu J ...
Publication Detail
COUP Transcription Factor II/genetics; COUP Transcription Factor II/metabolism*; CpG Islands; DNA Methylation; Drug Resistance ... Transient re-expression of COUP-TFII restores antiestrogen sensitivity in resistant LCC2 and LCC9 cells and repression of COUP- ... increased COUP-TFII suggesting that the decrease in COUP-TFII is mediated by epigenetic changes. Methylation-specific PCR (MSP ... Abstract: COUP-TFII is reduced in endocrine-resistant breast cancer cells and is negatively associated with tumor grade. ...
Biomarkers Search
Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age.. Tsai SY; Tsai MJ. Endocr Rev; 1997 Apr; 18( ... Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by ... EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor.. Zhang Y; Dufau ML. Mol Endocrinol; 2001 Nov; 15(11):1891 ... Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain ...
MeSH Browser
COUP Transcription Factor II Preferred Concept UI. M0184000. Registry Number. 0. Scope Note. A COUP transcription factor that ... COUP Transcription Factors [D12.776.260.643.039] * COUP Transcription Factor I [D12.776.260.643.039.249] ... COUP Transcription Factors [D12.776.826.209.039] * COUP Transcription Factor I [D12.776.826.209.039.249] ... COUP-TF2 Protein COUP-TFII Protein Chicken Ovalbumin Upstream Promoter-Transcription Factor II Nuclear Receptor NR2F2 Nuclear ...
Human immunodeficiency pathogen type 1 (HIV-1) gene transcription is usually seen - Generation of a selective small molecule...
Weve largely described that Sp1 and COUP-TF transcription factors are two of. ... Weve previously observed that this cellular transcription factors, Sp1 and Sp3, are directly bound to the LTR GC-box sequences ... Human immunodeficiency pathogen type 1 (HIV-1) gene transcription is usually seen as a two temporally unique stages. The probe ... Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K ...
RFA-DK-06-503: RFA-Announcement of a Limited Competition for the Continuation of the Nuclear Receptor Signaling Atlas (U19)
12:75, 2006). This is particularly so for NHRs given their position as ligand-dependent and -independent transcription factors ... COUP-TFI/II, SF-1, etc.). The latter have functions in tissues and cells but with no, or only poorly, defined ligand(s). While ... Part II Full Text of Announcement. Section I. Funding Opportunity Description 1. Research Objectives Section II. Award ... Background: NHRs comprise a large family of hormone-dependent and -independent transcription factors involved in reproduction, ...
MH DELETED MN ADDED MN
COUP Transcription Factor II D12.776.260.698.209.39.500 D12.776.260.643.39.500 D12.776.930.669.209.39.500 D12.776.930.780.750 ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
MeSH Browser
COUP Transcription Factor II Preferred Concept UI. M0184000. Registry Number. 0. Scope Note. A COUP transcription factor that ... COUP Transcription Factors [D12.776.260.643.039] * COUP Transcription Factor I [D12.776.260.643.039.249] ... COUP Transcription Factors [D12.776.826.209.039] * COUP Transcription Factor I [D12.776.826.209.039.249] ... COUP-TF2 Protein COUP-TFII Protein Chicken Ovalbumin Upstream Promoter-Transcription Factor II Nuclear Receptor NR2F2 Nuclear ...
Research Festival | Intramural Research Program | National Institutes of Health
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) regulates adult RT function and is expressed in the ... COUP-TFII: a new player in the dimorphic establishment of the male and female reproductive tracts in the mouse embryo. Friday, ... Surprisingly, this ablation resulted in the presence of two RTs in both males and females making this the first model where a ... Together, these data indicate that COUP-TFII mediates ductal regression by a mechanism other than gonadal hormone production ...
DeCS
COUP Transcription Factor II - Preferred Concept UI. M0184000. Scope note. A COUP transcription factor that negatively ... Chicken Ovalbumin Upstream Promoter Transcription Factor II Chicken Ovalbumin Upstream Promoter-Transcription Factor II Nuclear ... Chicken Ovalbumin Upstream Promoter Transcription Factor II. Chicken Ovalbumin Upstream Promoter-Transcription Factor II. ... factor de transcripción COUP II. Scope note:. Factor de transcripción COUP que actúa como regulador negativo de TRANSCRIPCIÓN, ...
Pharos : Target Details - NR2F2
The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. ... Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. This gene encodes a member of the steroid thyroid ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... Protein / Transcription Factor. / Coup Transcription Factor 2 Protein / Receptor. / Coup Transcription Factor 2 Protein / ...
EMT Upregulated
Results in the O-GlcNAc Database
Jun Eguchi - Research output - Okayama University
... transcription factor II is a critical regulator of adipogenesis. Xu, Z., Yu, S., Hsu, C. H., Eguchi, J. & Rosen, E. D., Feb 19 ... Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis. Eguchi, J., Yan, Q. W., Schones, D. E., Kamal, M. ... A report of two cases. Fujiwara, N., Watanabe, M., Katayama, A., Noda, Y., Eguchi, J., Kataoka, H., Kagawa, S. & Wada, J., Sept ... Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: Two case reports. Shibata, Y., ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
Dysregulated genes were enriched for MYC Proto-Oncogene, BHLH Transcription Factor (Myc)-binding sites, a known BPTF ... Over the past two decades soybeans grown in western Canada have persistently had lower seed protein than those grown in eastern ... COUP-TF-interacting protein 2 (Ctip2)+ neurons). RNAseq and pathway analysis identified altered expression of fate-determining ... Heterozygous variants in bromodomain and plant homeodomain containing transcription factor (BPTF) cause the neurodevelopmental ...
NDF-RT Code NDF-RT Name
N0000170110 COUP Transcription Factor I N0000170111 COUP Transcription Factor II N0000170109 COUP Transcription Factors ... Factor Brn-3A N0000169848 Transcription Factor Brn-3B N0000169847 Transcription Factor Brn-3C N0000169876 Transcription Factor ... Factor DP1 N0000169840 Transcription Factor Pit-1 N0000169958 Transcription Factor RelA N0000169957 Transcription Factor RelB ... Factors N0000169973 E2F1 Transcription Factor N0000169969 E2F2 Transcription Factor N0000169970 E2F3 Transcription Factor ...
Search Results | jme
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are orphan receptors involved in regulation of ... To explore novel transcriptional coregulators for COUP-TFs, we used the COUP-TFI as bait in a yeast two-hybrid screen of an ... Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription ... has no effect on Gal4-COUP-TFI-mediated repression activity. These findings indicate that interaction of Ubc9 with COUP-TFI is ...
G蛋白偶联受体在血管发育中的
Suppression of Notch signalling by the COUP-TFII tran-scription factor regulates vein identity. Nature, 2005, 435(7038): 98-104 ... 56] Carbajo-Lozoya J, Lutz S, Feng YX, Kroll J, Hammes HP, Wieland T. Angiotensin II modulates VEGF-driven an-giogenesis by ... Cytokine Growth Factor Rev, 2005, 16(6): 593-609.. [47] Addison CL, Daniel TO, Burdick MD, Liu H, Ehlert JE, Xue YY, Buechi L, ... 61] Tucker B, Hepperle C, Kortschak D, Rainbird B, Wells S, Oates AC, Lardelli M. Zebrafish Angiotensin II Receptor-like 1a ( ...
Research Briefs | NIH Intramural Research Program
A protein with the unwieldy name of chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) determines whether ... Without COUP-TFII, the mice are born intersex, or having both male and female reproductive tracts. The researchers will ... Two experimental vaccines can restrict Zika virus transmission from pregnant mice to their fetuses and can prevent Zika virus- ... In the brain, MRs are mainly located in the amygdala and the prefrontal cortex-two key brain areas involved in the development ...
Rare variants in NR2F2 cause congenital heart defects in humans. - SCNi
NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result ... two of which arose de novo) in the highly conserved gene NR2F2, a very significant enrichment (p = 7.7 × 10(-7)) compared to ... Animals, Binding Sites, COUP Transcription Factor II, Cell Line, Exome, Female, Heart Defects, Congenital, Humans, Male, Mice, ... NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result ...
Environmental Factor - January 2018: 2017 Papers of the Year
Using reverse transcription polymerase chain reaction, the researchers found higher expression of fibroblast growth factor in ... Using two types of adjuvants, TLR ligands and proteases, the researchers found they promoted distinct forms of airway ... Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science 357(6352):717−720. ( ... The scientists assessed p53 activity in human colon cancer cells (HCT-116). p53 is a transcription factor that is activated in ...
The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer...
1993) Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene ... is a complex array of transcription factor-binding sites that includes at least two elements (designated dNR1 and dNR2) that ... COUP-TF. chicken ovalbumin upstream promoter-transcription factor. PCR. polymerase chain reaction. PCN. pregnenolone 16α- ... BglII-digested p3A4-362. This construct was linearized with BglII, and a 948-bp BglII fragment of p3A4-C1 (bases −1310 to −362 ...
MH DELETED MN ADDED MN
COUP Transcription Factor II D12.776.260.698.209.39.500 D12.776.260.643.39.500 D12.776.930.669.209.39.500 D12.776.930.780.750 ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
MH DELETED MN ADDED MN
COUP Transcription Factor II D12.776.260.698.209.39.500 D12.776.260.643.39.500 D12.776.930.669.209.39.500 D12.776.930.780.750 ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
MH DELETED MN ADDED MN
COUP Transcription Factor II D12.776.260.698.209.39.500 D12.776.260.643.39.500 D12.776.930.669.209.39.500 D12.776.930.780.750 ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
MH DELETED MN ADDED MN
COUP Transcription Factor II D12.776.260.698.209.39.500 D12.776.260.643.39.500 D12.776.930.669.209.39.500 D12.776.930.780.750 ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
Aging is a Military Coup | Josh Mitteldorf
Is it reasonable for an enzyme thats lacking substrate to become a transcription factor for the production enzymes and ... Two questions : when does the book come out ? And have you decided not to bother updating the index.. I wanted to refresh my ... 42 thoughts on "Aging is a Military Coup" * Bill Hankin on April 17, 2016 at 2:42 pm. said: ... Aging is a Military Coup. Posted on April 17, 2016. by Josh Mitteldorf ...
Pregnancy & Female Reproduction Group - Regulation of Embryo Development
... and transcription factor analysis. These tools allow them to examine factors that allow proper embryo implantation, adequate ... These two organ systems are under constant exposure to the environment and represent systems that are vital for life and the ... Defining the roles of the progesterone receptor and COUP-TFII, and their involvement in uterine expansion and birth. ... Examining the role of transcription factors in controlling the muscle layer of the uterus, the myometrium to expand during ...
NR2F2ProteinRegulatesLigand inducible transcriptionProteinsTranscriptional factorRepressionGenesRECEPTORSCompetesTumorNeuronsGene expressionRegulateMouse embryoMediatesRepressorRegulationPromoterMAPKAndrogenReplicationPathwaysEmbryonicGrowthOrphanVascularVariantsHormonesDifferentiationMutantPlantsDevelopmentFoundExpressionCellsTermHumanFamily
NR2F24
- Translational importance is suggested by Cancer Methylome System (CMS) analysis revealing that breast tumors have increased COUP-TFII (NR2F2) promoter and gene methylation versus normal breast. (nih.gov)
- We performed exome sequencing in 13 parent-offspring trios and 112 unrelated individuals with nonsyndromic AVSDs and identified five rare missense variants (two of which arose de novo) in the highly conserved gene NR2F2, a very significant enrichment (p = 7.7 × 10(-7)) compared to 5,194 control subjects. (ox.ac.uk)
- NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result in abnormal development of atrioventricular septa. (ox.ac.uk)
- BMP2 (bone morphogenetic protein 2) and FKBP4 (FK506 binding protein 4) worked as down-stream target genes of HH-NR2F2 axis, which were necessary and sufficient for implantation and decidualization. (biomedcentral.com)
Protein11
- Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo. (nih.gov)
- 34. A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction and chicken ovalbumin upstream promoter transcription factor 1 repression. (nih.gov)
- For supershift tests, GST fusion protein had been incubated with the principal antibodies: anti-COUP-TF (kindly supplied by J. E. Mertz), anti-CTIP2 and anti-Sp1 (Santa Cruz Biotechnology) for 16 h before adding the probe. (columbiagypsy.net)
- The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. (nih.gov)
- Over the past two decades soybeans grown in western Canada have persistently had lower seed protein than those grown in eastern Canada. (bvsalud.org)
- BPTF functions within nucleosome and remodeling factor (NURF), a complex comprising sucrose non-fermenting like (SNF2L), an Imitation SWItching (ISWI) chromatin remodeling protein encoded by the SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1) gene. (bvsalud.org)
- COUP-TF-interacting protein 2 (Ctip2)+ neurons). (bvsalud.org)
- The mutant mice lacked COUP-TFII, a protein involved in development, in the embryonic structure that develops into the male and female reproductive tracts. (nih.gov)
- Two years later, we cloned the cDNA of this protein and identified it as lactoferrin. (nih.gov)
- HIF1 alpha antibody recognizes HIF1 alpha (HIF1a) protein, which is a subunit of the heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1). (genetex.com)
- Together with metastasis-associated protein-2 MTA2 , it deacetylates p53 and modulates its effect on cell growth and apoptosis. (wikidoc.org)
Regulates6
- Our data show that SCF stimulates Erk1/2 MAPK signaling pathway, which regulates the downstream repressor COUP-TFII by inhibiting serine/threonine phosphatase 2A activity, and that decreased COUP-TFII expression resulted in gamma-globin reactivation in adult erythropoiesis. (nih.gov)
- Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
- Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
- A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. (nih.gov)
- Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) regulates adult RT function and is expressed in the mesenchyme of the embryonic gonad and mesonephros. (nih.gov)
- Suppression of Notch signalling by the COUP-TFII tran-scription factor regulates vein identity. (chinagene.cn)
Ligand inducible transcription1
- Many of the NRs act as ligand-inducible transcription factors, responding to endogenous and exogenous chemicals. (nrresource.org)
Proteins7
- 29. A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter. (nih.gov)
- RESULTS CTIP1 and CTIP2 proteins repress HIV-1 gene transcription via the LTR proximal region As previously shown, CTIP1 and CTIP2 proteins inhibited the LTR-driven transcription in transient transfection assays (Figure 1, lanes 2 and 3) (25). (columbiagypsy.net)
- Deletion from the 5 region downstream of both proximal GC-box sequences didn't affect CTIP1 and CTIP2 capability to repress LTR-driven CAT activity (Figure 1, lanes 5 and 6), indicating that CTIP proteins repressive function could be mediated from the proximal region from the LTR encompassing two GC-box sequences, the CATA sequence (21) as well as the TAR region. (columbiagypsy.net)
- These proteins are intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules. (nrresource.org)
- AFP AA sequences are further presented as peptide identification sites for growth factors, receptors, cytoskeletal proteins, and chemokines. (atlasgeneticsoncology.org)
- Histone H1 homologs are rare among prokaryotes, but C. trachomatis possesses two proteins that have primary amino acid sequence homology to eukaryotic H1. (nih.gov)
- Factors involved in the development of these diseases, from signaling through cell surface receptors to regulation of gene transcription, are considered to be controlled by dynamic networks consisting of multiple complexes of different proteins. (dppir.com)
Transcriptional factor1
- Activation of Erk1/2 plays a critical role in SCF modulation of downstream transcriptional factor COUP-TFII, which is involved in the regulation of gamma-globin gene induction. (nih.gov)
Repression6
- Transient re-expression of COUP-TFII restores antiestrogen sensitivity in resistant LCC2 and LCC9 cells and repression of COUP-TFII results in antiestrogen-resistance in MCF-7 endocrine-sensitive cells. (nih.gov)
- 26. Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. (nih.gov)
- The C-terminal region of Ubc9 encoding amino acids 59-158 interacts with the C-terminus of COUP-TFI encoding amino acids 383-403, in which transcriptional repression domains are located. (bioscientifica.com)
- Transfection of Ubc9 into COS-1 cells markedly enhances transcriptional repression by Gal4 DNA-binding domain-fused to COUP-TFI(155-423), but not by Gal4-COUP-TFI(155-388) which lacks a repressor domain. (bioscientifica.com)
- Coexpression of a C-terminal deletion mutant of Ubc9(1-58), which fails to interact with COUP-TFI, but retains a transcriptional repression domain, has no effect on Gal4-COUP-TFI-mediated repression activity. (bioscientifica.com)
- Overexpression of Ubc9 similarly enhances COUP-TFI-dependent repression of the promoter activity of the bovine CYP17 gene encoding steroid 17alpha-hydroxylase. (bioscientifica.com)
Genes7
- It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL . (nih.gov)
- Asimismo, puede estimular la transcripción de genes involucrados en el METABOLISMO de la GLUCOSA y el COLESTEROL. (bvsalud.org)
- Dysregulated genes were enriched for MYC Proto-Oncogene, BHLH Transcription Factor (Myc)-binding sites, a known BPTF transcriptional cofactor. (bvsalud.org)
- Regulatory network inference is the elucidation of transcriptional regulation interactions between regulator genes called transcription factors and their gene targets. (archives-ouvertes.fr)
- The two problems mentioned above share a common feature: they are both prioritization problems for which positive examples exists in small amounts (confirmed interactions or identified disease genes) but no negative data is available. (archives-ouvertes.fr)
- We found that more than 300 genes are differentially expressed in NPY-positive neurons between these two brain regions. (eneuro.org)
- A few hundred genes were found to be differentially expressed in NPY-positive neurons between these two brain regions, including AMPA receptor (AMPAR) auxiliary subunit Shisa9/CKAMP44 and the 5HT2a receptor (5HT2aR). (eneuro.org)
RECEPTORS1
- Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are orphan receptors involved in regulation of neurogenesis and organogenesis. (bioscientifica.com)
Competes1
- We found that Chicken Ovalbumin Upstream Promotor (COUP)-transcription factor competes with estrogen receptor for binding to the estrogen-response element of the lactoferrin gene in mice, but not in humans. (nih.gov)
Tumor2
- COUP-TFII is reduced in endocrine-resistant breast cancer cells and is negatively associated with tumor grade. (nih.gov)
- An analysis of transcription factors, tumor suppressors, and AA-rich motifs follows, interfaced with dimerization and nuclear localization sequence matches identified on the AFP molecule. (atlasgeneticsoncology.org)
Neurons1
- They found that the target neurons belong to two broad categories, both of which were insensitive to gentle stimulation. (nih.gov)
Gene expression1
- 24. Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells. (nih.gov)
Regulate1
- 38. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (nih.gov)
Mouse embryo1
- The female mouse embryo without COUP-TFII (bottom) has both male, in blue, and female reproductive tracts. (nih.gov)
Mediates2
- Together, these data indicate that COUP-TFII mediates ductal regression by a mechanism other than gonadal hormone production and suggests that mesonephric mesenchymal COUP-TFII signals ductal epithelial cell regression. (nih.gov)
- Our results provide evidence for the existence of a potent enhancer module, 8 kb distal to the transcription start point, which mediates the transcriptional induction of CYP3A4 by activators of hPXR. (aspetjournals.org)
Repressor1
- Here, we examined COUP-TFII as a potential repressor of gamma-globin gene after stem cell factor (SCF) stimulation in cultured human adult erythroid progenitor cells. (nih.gov)
Regulation3
- Furthermore, down-regulation of COUP-TFII expression with small interfering RNA (siRNA) significantly increases the gamma-globin expression during the erythroid maturation. (nih.gov)
- Regulation of the apolipoprotein A-I gene transcription. (nih.gov)
- 2] Adams RH, Alitalo K. Molecular regulation of angiogene-sis and lymphangiogenesis. (chinagene.cn)
Promoter2
- 37. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. (nih.gov)
- 39. Stimulation of aromatase P450 promoter (II) activity in endometriosis and its inhibition in endometrium are regulated by competitive binding of steroidogenic factor-1 and chicken ovalbumin upstream promoter transcription factor to the same cis-acting element. (nih.gov)
MAPK1
- Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways. (nih.gov)
Androgen2
Replication1
- In Escherichia coli , Hc1 expression is self-limiting and produces a global termination of transcription, translation, and replication at concentrations equivalent to those found in chlamydial EBs. (nih.gov)
Pathways1
- RNAseq and pathway analysis identified altered expression of fate-determining transcription factors and the biological pathways involved in neural development, apoptotic signaling and amino acid biosynthesis. (bvsalud.org)
Embryonic2
- To determine its role in RT development, COUP-TFII was ablated in the embryonic gonad and mesonephros. (nih.gov)
- Implantation process is one of the important factors that affect litter size in pigs, owing to the high embryonic mortality during this stage. (biomedcentral.com)
Growth2
Orphan2
- Moreover, the orphan nuclear receptor COUP-TF is indirectly anchored to the region via its association with Sp1 (13). (columbiagypsy.net)
- Two of these sites, FP3 (bases −7738 to −7715) and FP4 (bases −7698 to −7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). (aspetjournals.org)
Vascular1
- The vascular development consists of two continuous processes: vasculogenesis and angiogenesis. (chinagene.cn)
Variants1
- Heterozygous variants in bromodomain and plant homeodomain containing transcription factor (BPTF) cause the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL) syndrome (MIM#617755) characterized by intellectual disability, speech delay and postnatal microcephaly. (bvsalud.org)
Hormones1
- This process is controlled by two hormones: androgens and anti-Müllerian hormone (AMH). (nih.gov)
Differentiation1
- RT development depends on the regression and differentiation of two primitive mesonephric ducts into a single RT. (nih.gov)
Mutant1
- In addition, the C93S mutant of Ubc9, which abrogates SUMO-1 conjugation activity, continues to function as a COUP-TFI corepressor. (bioscientifica.com)
Plants1
- In this NAMZARIC newspaper, Pollack requires his polymerase is the lesser of two French Plants up after three same activities comprise shown. (choyleefutchile.cl)
Development1
- Also we will determine how these factors impact the development of reproductive diseases such as endometriosis and endometrial cancer. (nih.gov)
Found2
- We found that COUP-TFII expression is suppressed by SCF through phosphorylation of serine/threonine phosphatase (PP2A) and correlated well with fetal hemoglobin induction. (nih.gov)
- Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. (genetex.com)
Expression2
Cells4
- We've previously observed that this cellular transcription factors, Sp1 and Sp3, are directly bound to the LTR GC-box sequences in microglial cells (13). (columbiagypsy.net)
- Fluorescence imaging studies show that both Ubc9 and COUP-TFI are colocalized in the nuclei of transfected COS-1 cells. (bioscientifica.com)
- Scientists have been studying the complex factors that enable cells within different types of tissues to communicate with each other and drive embryo formation. (nih.gov)
- Both neuroglia and Ivy cells express NPY but are considered two separate classes based on their anatomic position. (eneuro.org)
Term1
- For short-term storage (1-2 weeks), store at 4ºC. (genetex.com)
Human1
- Human immunodeficiency pathogen type 1 (HIV-1) gene transcription is usually seen as a two temporally unique stages. (columbiagypsy.net)
Family1
- COUP-TF family members are generally considered to be transcriptional repressors and several mechanisms have been proposed to underlie this activity. (bioscientifica.com)
