COUP Transcription Factor II: A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.COUP Transcription Factor I: A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Insulin-Like Growth Factor II: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Forehead: The part of the face above the eyes.Facial Hemiatrophy: A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.Receptors, Retinoic Acid: Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.Nuclear Receptor Subfamily 1, Group F, Member 1: A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.Receptors, Thyroid Hormone: Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Schools, Pharmacy: Educational institutions for individuals specializing in the field of pharmacy.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.College Admission Test: Test designed to identify students suitable for admission into a graduate or undergraduate curriculum.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Students, Pharmacy: Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.Pharmacies: Facilities for the preparation and dispensing of drugs.Orchiectomy: The surgical removal of one or both testicles.TexasAndrostenols: Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.Los AngelesProstatic Neoplasms, Castration-Resistant: Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Phenylthiohydantoin: Thiohydantoin benzene derivative.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)Dystrophin: A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.Electron Microscope Tomography: A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.Dopamine and cAMP-Regulated Phosphoprotein 32: A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Transdermal Patch: A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. (1/142)

The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/142)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter. (3/142)

Seven mutations in the hepatocyte nuclear factor (HNF)-4alpha gene have been shown to correlate with type 1 maturity-onset diabetes of the young (MODY 1), a monogenic form of type 2 diabetes. Up to now, only the functional properties of two MODY 1 HNF-4alpha mutants, Q268X and V393I, have been investigated to address how the mutations in the HNF-4alpha gene, found by genetic studies, can give rise to impaired activities of mutated HNF-4alpha proteins and can cause this disease. The E276Q mutation results in a nonconservative substitution occurring in the HNF-4alpha E domain, which is involved in dimerization and transactivation activities as well as in protein-protein interactions with other transcription factors or coactivators. Using the mutated human HNF-4alpha2, we have found that, in the absence of chicken ovalbumin upstream promoter transcription factor II (COUP TFII), the E276Q substitution does not significantly affect the dimerization and transactivating activities of HNF-4alpha, at least on the promoters studied herein. On the other hand, in the presence of COUP TFII, the substitution impairs the enhancement of HNF-4-mediated activation of HNF-1 promoter. The impaired synergy between COUP TFII and HNF-4 on the HNF-1 promoter results from an alteration of their interaction. HNF-1 expression plays a crucial role in transactivation of insulin promoter and of numerous genes coding for enzymes involved in glucose homeostasis. Therefore, its downregulation resulting from the E276Q mutation in HNF-4alpha gene most probably impairs the function of pancreatic beta-cells.  (+info)

Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. (4/142)

Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase CYP26. Subsequently in the embryonic retina, CYP26 forms a narrow horizontal boundary between the dorsal and ventral dehydrogenases, creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal and ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns.  (+info)

Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response. (5/142)

Transcription of the L-type pyruvate kinase (L-PK) gene is induced by glucose in the presence of insulin and repressed by glucagon via cyclic AMP. The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs). From ex vivo and in vivo experiments, it appears that USFs are required for correct response of the L-PK gene to glucose, but their expression and binding activity are not known to be regulated by glucose. A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i.e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). Binding of COUP-TFII to the GlRE was confirmed by electrophoretic mobility shift assays, and COUP-TFII-containing complexes were detectable in liver nuclear extracts. Neither abundance nor binding activity of COUP-TFII appeared to be significantly regulated by diets. In footprinting experiments, two COUP-TFII-binding sites overlapping the E boxes were detected. Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. In addition, a mutated GlRE with increased affinity for USF and very low affinity for COUP-TFII conferred a dramatically decreased glucose responsiveness on the L-PK promoter in hepatocytes in primary culture by increasing activity of the reporter gene in low glucose condition. We propose that COUP-TFII could be a negative regulatory component of the glucose sensor complex assembled on the GlRE of the L-PK gene and most likely of other glucose-responsive genes as well.  (+info)

Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (6/142)

The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.  (+info)

HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). (7/142)

The gene for cholesterol 7alpha-hydroxylase (CYP7A1) contains a sequence at nt -149 to -118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) synergistically activate transcription of the CYP7A1 promoter. Transactivation of CYP7A1 by HNF4 in the human hepatoma cell line, HepG2, was enhanced by cotransfection with COUP-TFII or the basal transcription element binding protein (BTEB). HNF4 prepared from rat liver nuclear extracts bound to oligomers homologous to the nt -146 to -134 sequences in electrophoretic mobility shift assays (EMSA), which corresponded to a conserved region containing a direct repeat of hormone response elements spaced by one nucleotide (DR1). The sequences surrounding this DR1 were found to be essential for the HNF4 transactivation. In vitro-translated COUP-TFII was found to bind the adjacent sequences from nt -139 to -128 (DR0), but COUP-TFII interacted with this region at a much lower affinity than to the COUP-TFII-site at nt -72 to -57 (DR4). Mutations at nt -139 to -128 or nt -72 to -57 reduced the COUP-TFII and HNF4 synergy; however, these COUP-TFII-binding sequences were not absolutely required for the cooperative effect of HNF4 and COUP-TFII on transactivation. These results indicated that the observed transactivation was the result of protein/protein interactions facilitated by the juxtaposition of the binding elements.  (+info)

ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. (8/142)

Actin related protein of vertebrate, Arp1, is a major component of the dynactin complex. To characterise and localise Arp1 during mammalian spermatogenesis, polyclonal antibodies were raised against a human recombinant Arp1. Anti-Arp1 antibodies were used for western-immunoblotting, indirect immunofluorescence and immunoelectron microscopy. In round spermatids, Arp1 was detected at the centrosome and at the Golgi apparatus. In elongated spermatids, Arp1 was predominantly found along microtubules of the manchette and at their site of attachment to the nuclear envelope. In maturing spermatids, Arp1 was still present in the pericentriolar material, but in testicular spermatozoa it was not detectable. These various localisations of Arp1 and their changes during spermatid differentiation suggest that the dynactin complex in association with dynein might contribute to several activities: the functional organisation of the centrosome and of the Golgi apparatus and the shaping of the nucleus by manchette microtubules.  (+info)

*Griffin P. Rodgers

... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...

*BCL11B

"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. Recent research suggests ... Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). "COUP-TF (chicken ovalbumin upstream promoter transcription ... BCL11B has been shown to interact with COUP-TFI. GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017 GRCm38: ...

*Nucleolin

... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ... COUP-TFII). Midkine and pleiotrophin bind to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV ...

*Sirtuin 1

"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... "The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms". Genes & ... which are essential metabolic regulatory transcription factors. In mammals, SIRT1 has been shown to deacetylate and thereby ... which are essential metabolic regulatory transcription factors. Human aging is characterized by a chronic, low-grade ...

*Uteroglobin

"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... 2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney". J. Biol. Chem. 276 (16): 13295- ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ... "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis ...

*BCL11A

... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... BCL11A has been shown to interact with COUP-TFI. GRCh38: Ensembl release 89: ENSG00000119866 - Ensembl, May 2017 GRCm38: ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315-22. doi:10.1074/jbc.275.14.10315. PMC 2819356 . PMID ...

*COUP-TFI

"Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...

*COUP-TFII

"Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ...

*Chicken ovalbumin upstream promoter-transcription factor

COUP Transcription Factor I at the US National Library of Medicine Medical Subject Headings (MeSH) COUP Transcription Factor II ... There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively. ... COUP Transcription Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ...

*Nerve growth factor IB

Cofactors interact with NGFI-B at a hydrophobic region between helices 11 and 12 to modulate transcription. Along with the two ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... Nerve growth factor IB is a member of the Nur nuclear receptor family of intracellular transcription factors. NGFIB is involved ... This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ...

*Estrogen receptor alpha

Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen ... Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hERα-COUP-TFI ... Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ...

*Retinoid X receptor alpha

"Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ...

*Zinc finger transcription factor

Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... COUP-TF *(I. *II. *Ear-2. *HNF4 *α. *γ. *PNR. *RXR *α ... Artificial transcription factor, of which the ZF-TF is a type. ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...

*Aryl hydrocarbon receptor

Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Arch. ... The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ...

*Ceramide kinase

... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide-1-phosphate. This enzyme ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ...

*FGF8

Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a ... 2002). "Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer". Br. J. Cancer ...

*V-erbA-related gene

"Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ... "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...

*FOXP2 - 维基百科,自由的百科全书

第二亚族(COUP-TF(英语:Chicken ovalbumin upstream promoter-transcription factor)(I、II)、Ear-2(英语:V-erbA-related gene)、HNF4(英语: ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... GATA(英语:GATA transcription factor)(1、2、3、4、5、6) · MTA(1、2、3) · TRPS1(英语:Tricho-rhino-phalangeal syndrome Type

*Lck

... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... The two main phosphorylation sites on Lck are tyrosines 394 and 505. The former is an autophosphorylation site and is linked to ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): ...

*List of MeSH codes (D12.776)

... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... macrophage-activating factors MeSH D12.776.467.374.480.615.350 - interferon type ii MeSH D12.776.467.374.480.625 - macrophage ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ...

*Mary-Claire King

"Expression profiling in primates reveals a rapid evolution of human transcription factors". Nature. 440 (7081): 242-245. doi: ... 11, 1973, in a CIA-backed coup. She has been supportive of women and ethnic and sexual minorities in science, and critical of ... "Evolution at two levels in humans and chimpanzees". Science. 188 (4184): 107-116. doi:10.1126/science.1090005. PMID 1090005. ... but researchers were skeptical about the use of genetics in the more common diseases caused by multiple genetic factors as well ...

*List of MeSH codes (D12.776.930)

... coup transcription factor i MeSH D12.776.930.682.074.500 -- coup transcription factor ii MeSH D12.776.930.682.350.174 -- ... transcription factor brn-3b MeSH D12.776.930.632.625.875 -- transcription factor brn-3c MeSH D12.776.930.635.600.100 -- ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 -- mafk transcription factor MeSH D12.776.930.127.656.770 -- nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 -- mafk transcription factor MeSH D12.776.930.316.750.770 -- nf-e2 ...

*Nuclear receptor

... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... In addition, two additional classes, type III which are a variant of type I, and type IV that bind DNA as monomers have also ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally ...

*HDAC1

"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (December 2002). "MBD3 and HDAC1, two components of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ...

*Hawaiian language

These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... The banishment was only two years removed from acknowledgement as a legitimate sovereign government. From July 1894 to January ... in making handwritten transcriptions of Hawaiian vowels. The missionaries specifically requested their sponsor in Boston to ... The decline of the Hawaiian language dates back to a coup that overthrew the Hawaiian monarchy and dethroned the existing ...

*Leadership analysis

He is the most expressive post-World War II president and with high adverbial intensifiers, he is an actor who displays ... Applied analysts make great use of the psychobiography, while academics tend to analyze transcriptions in search of traits and ... Relate personality to key issues, emphasizing in which direction the psychological factors point. Estimate drives, values, and ... when most leaders of coups emerge), or in old age, when leaders, especially narcissists, feel the reins of power slipping and ...

*HOXD8

RNA polymerase II transcription regulatory region sequence-specific binding. • RNA polymerase II transcription factor activity ... transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... regulation of transcription from RNA polymerase II promoter. • skeletal system morphogenesis. • transcription, DNA-templated. • ...

*NF-κB - 维基百科,自由的百科全书

第二亚族(COUP-TF(I、II)、Ear-2、HNF4(α、γ)、PNR、RXR(α、β、γ)、Testicular receptor(2、4)、TLX). 第三亚族(甾类激素(英语:Steroid hormone receptor)(雄激素、雌激素 ... Handbook of Transcription Factor NF-κB. Boca Raton: CRC. 2006. ISBN 0-8493-2794-6.. ... BBX(英语:BBX (gene)) · HMGB(1(英语:HMGB1)、2(英语:HMGB2)、3(英语:HMGB3)、4(英语:HMGB4)) · HMGN(英语:HMGN)、(1(英语:HMGN1)、2(英语:HMGN2)、3(英语:HMGN3) ... 核因子活化B细胞κ轻链增强子(英語:nuclear factor kappa-light
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
Sigma-Aldrich offers abstracts and full-text articles by [Jae Hyeon Kim, Jin-Kyu Kim, Eun-Kyung Ahn, Hye-Jin Ko, Young-Rak Cho, Choong Hyun Lee, Yong Kee Kim, Gyu-Un Bae, Joa Sub Oh, Dong-Wan Seo].
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
J:244916 Zhao F, Franco HL, Rodriguez KF, Brown PR, Tsai MJ, Tsai SY, Yao HH, Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017 Aug 18;357(6352):717-720 ...
Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated the importance of this pathway in driving artery endothelial cell differentiation. However, when and where Notch activation occurs to affect endothelial cell fate is less clear. Using transgenic zebrafish bearing a Notch-responsive reporter, we demonstrate that Notch is activated in endothelial progenitors during vasculogenesis prior to blood vessel morphogenesis and is maintained in arterial endothelial cells throughout larval stages. Furthermore, we find that endothelial progenitors in which Notch is activated are committed to a dorsal aorta fate. Interestingly, some arterial endothelial cells subsequently downregulate Notch signaling and then contribute to veins during vascular remodeling. Lineage analysis, together with perturbation of both Notch receptor and ligand function, further suggests several distinct
LXR α 0h 4h 8h 18h 1D 2D 3D 4D 5D 6D 7D 8D h 2d d Induction MediumDifferentiation Medium NR Expression during Adipogenesis of 3T3-L1 Cells (2) Fu et al., Mol. Endo. 19: 2437 (2005) Nur77 PPAR γ NUR77 LXR  PPAR 

JCI -
COUP-TFII regulates satellite cell function and muscular
                    dystrophyJCI - COUP-TFII regulates satellite cell function and muscular dystrophy

... identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor ... suggesting that targeting COUP-TFII is a potential treatment for DMD. Together, our findings reveal a regulatory role of COUP- ... regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC function and counteracted the ... Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated ...
more infohttps://www.jci.org/articles/view/87414/pdf

The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...

The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ... COUP-TFs) are members from. The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the ... The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from ... The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et ...
more infohttp://biodiversityhotspot.org/2019/06/the-chicken-ovalbumin-upstream-promoter-transcription-factors-coup-tfs-are-members-from/

JCI -
WelcomeJCI - Welcome

... identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor ... suggesting that targeting COUP-TFII is a potential treatment for DMD. Together, our findings reveal a regulatory role of COUP- ... regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC function and counteracted the ... Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated ...
more infohttps://sdjiaheng.net.insight.mobile.jci.org/articles/view/87414/cite

COUP transcription factor 2 (P24468) | InterPro | EMBL-EBICOUP transcription factor 2 (P24468) | InterPro | EMBL-EBI

GO:0003700 DNA-binding transcription factor activity GO:0003707 steroid hormone receptor activity GO:0004879 nuclear receptor ...
more infohttp://www.ebi.ac.uk/interpro/protein/P24468

Nr2f2 - COUP transcription factor 2 - Mus musculus (Mouse) - Nr2f2 gene & proteinNr2f2 - COUP transcription factor 2 - Mus musculus (Mouse) - Nr2f2 gene & protein

Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... COUP transcription factor 2Add BLAST. 414. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter.". Huggins G.S., ...
more infohttp://www.uniprot.org/uniprot/P43135

Bovine COUP transcription factor 2, NR2F2 ELISA KITBovine COUP transcription factor 2, NR2F2 ELISA KIT

NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Starting at: $796.00. *Model: ELI-25413b ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Product Name:Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Packing: ... Target Protein Name:Bovine COUP transcription factor 2, NR2F2 Alternative Name:NR2F2,Bovine COUP transcription factor 2, NR2F2 ...
more infohttps://www.lifescience-market.com/bovine-elisa-kit-c-65_73/bovine-coup-transcription-factor-2-nr2f2-elisa-kit-p-32631.html

Nr2f1 - COUP transcription factor 1 - Mus musculus (Mouse) - Nr2f1 gene & proteinNr2f1 - COUP transcription factor 1 - Mus musculus (Mouse) - Nr2f1 gene & protein

positive regulation of transcription by RNA polymerase II Source: Ensembl. *transcription, DNA-templated Source: UniProtKB- ... COUP transcription factor 1Imported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,Q32NY6,Q32NY6_MOUSE COUP transcription factor 1 OS=Mus musculus OX=10090 GN=Nr2f1 PE=1 SV=1 ... Transcription, Transcription regulationPROSITE-ProRule annotation. ,p>Information which has been generated by the UniProtKB ...
more infohttp://www.uniprot.org/uniprot/Q32NY6

COUP Transcription Factors
     Summary Report | CureHunterCOUP Transcription Factors Summary Report | CureHunter

COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a ... 09/01/2010 - "Here, we review the emerging role(s) of orphan nuclear receptors in breast cancer, with a particular focus on two ... COUP Transcription Factors. Subscribe to New Research on COUP Transcription Factors A sub-family of steroid receptor-related ...
more infohttp://www.curehunter.com/public/keywordSummaryD051836-COUP-Transcription-Factors.do

Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6

IPR003068 Transcription factor COUP. IPR013088 Zinc finger, NHR/GATA-type. IPR001628 Zinc finger, nuclear hormone receptor-type ... J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2): ... J:215426 Ichim CV, et al., The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development. Exp ... 1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus. ...
more infohttp://www.informatics.jax.org/marker/MGI:1352453

Nuclear receptors as target of new drug therapyNuclear receptors as target of new drug therapy

Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li,6: V-erbA-related ... COUP /EAR ,/li,,/ul,,ul,,ul,,li,1: Chicken ovalbumin upstream promoter-transcription factor I ( COUP-TFI ; NR2F1 ) ,/li,,/ul,,/ ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ...
more infohttps://www.slideshare.net/HabiburRahman5/nuclear-receptors-as-target-of-new-drug-therapy

Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical...Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical...

Università degli Studi di Napoli Federico II. Department:. Biologia strutturale e funzionale. ... Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical ... The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and ... Romano, Anna Lisa (2013) Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis ...
more infohttp://www.fedoa.unina.it/9556/

Publications | Griffin P. Rodgers, M.D., M.A.C.P. | NIDDKPublications | Griffin P. Rodgers, M.D., M.A.C.P. | NIDDK

SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.. Aerbajinai W, Zhu J, ... The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.. Chin KL, Aerbajinai W ... Glia maturation factor-γ mediates neutrophil chemotaxis.. Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.. J Leukoc ... Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.. Aerbajinai W, Liu L, Zhu J, Kumkhaek ...
more infohttps://www.niddk.nih.gov/about-niddk/staff-directory/biography/rodgers-griffin/publications

NR2F2 (human)NR2F2 (human)

COUP transcription factor 2 Show on y-axis - References (HTP + LTP). References (LTP). References (HTP). Mutation Frequency in ...
more infohttps://www.phosphosite.org/proteinAction.action?id=19706&showAllSites=true

Griffin P. Rodgers - WikipediaGriffin P. Rodgers - Wikipedia

... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
more infohttps://en.wikipedia.org/wiki/Griffin_P._Rodgers

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum | Biochemical JournalCalreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum | Biochemical Journal

COUP-TF1, chicken ovalbumin upstream promoter-transcription factor 1; CTL, cytotoxic T-lymphocyte; EDEM, ER degradation- ... Abbreviations: BiP, immunoglobulin heavy-chain-binding protein; CaMKII, Ca2+/calmodulin-dependent protein kinase II; C/EBP, ... nuclear factor of activated T-cells; Nkx2.5, NK2 transcription factor related, locus 5; PACS-2, phosphofurin acidic cluster ... transforming growth factor; TSP-1, thrombospondin 1; UGGT, UDP-glucose:glycoprotein transferase ...
more infohttp://www.biochemj.org/content/417/3/651

JCI -
Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancerJCI - Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer

Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment ... Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. J ... Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005;310(5748):644-648.. View this ... In addition, since NCoA2 does not directly bind to DNA, it is currently unclear which transcription factor(s) cooperates with ...
more infohttps://www.jci.org/articles/view/76412

Plus itPlus it

COUP-TF, chicken ovalbumin upstream promoter transcription factor; EAR-2, v-erbA-related; NURR1, NR-related 1; NOR1, neuron- ... Mammalian Two-Hybrid Assay. The mammalian two-hybrid system (Promega) consists of VP16-hPXR (wild-type or mutant), Gal4-SRC-1, ... Tang ED, Nuñez G, Barr FG, and Guan KL (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem ... Pregnane X receptor (PXR) is a member of the nuclear receptor (NR) family of ligand-activated transcription factors and is ...
more infohttp://dmd.aspetjournals.org/content/37/4/719

Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus...Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus...

Expression level of Coup-TFII and Ucp3 mRNA in tissues of P. sungorus. Coup-TFII mRNA is expressed in all examined tissue types ... Several studies have demonstrated interaction of these factors with chicken ovalbumin upstream promoter transcription factor II ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17204145?dopt=Abstract

Similar articles for PubMed (Select 14976264) - PubMed - NCBISimilar articles for PubMed (Select 14976264) - PubMed - NCBI

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Mammalian SIRT1 represses forkhead transcription factors.. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, ... Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.. Brunet A, Sweeney LB, Sturgill JF, Chua KF ... FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed&from_uid=14976264

RMND5B Gene - GeneCards | RMD5B Protein | RMD5B AntibodyRMND5B Gene - GeneCards | RMD5B Protein | RMD5B Antibody

Top Transcription factor binding sites by QIAGEN in the RMND5B gene promoter:. *COUP ... No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ... Transcription Factor. Binding Sites. Gene Targets. GH05J178129. Promoter/Enhancer. 2.2. EPDnew Ensembl ENCODE CraniofacialAtlas ... The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=RMND5B&keywords=GH05J178103&prefilter=genomic_location

COUP-TF I/NR2F1 Antibody (NBP2-15974): Novus BiologicalsCOUP-TF I/NR2F1 Antibody (NBP2-15974): Novus Biologicals

Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation ... Alternate Names for COUP-TF I/NR2F1 Antibody. *COUP transcription factor 1 ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ...
more infohttps://www.novusbio.com/products/coup-tf-i-nr2f1-antibody_nbp2-15974

Frontiers | Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal...Frontiers | Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal...

Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse ... As the two phenotypes are not identical, a cross-repression between the two receptors appears to be unlikely. The sequential ... It will greatly improve our understanding of transcription factors, like RORα and TRα1, which are already well known to be ... suggesting that several of the small ligand molecules that bind these transcription factors are required locally. We have ...
more infohttps://www.frontiersin.org/articles/10.3389/fnana.2012.00011/full

BCL11B - WikipediaBCL11B - Wikipedia

"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. Recent research suggests ... Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). "COUP-TF (chicken ovalbumin upstream promoter transcription ... BCL11B has been shown to interact with COUP-TFI. GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017 GRCm38: ...
more infohttps://en.wikipedia.org/wiki/BCL11B

Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum |...Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum |...

2002) COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific ... 4M,M′), usually with only one or two large areas of dense staining in the subcallosal streak (Fig. 4N,N′). These data indicate ... We demonstrated previously that the transcription factor COUP TF1-interacting protein 2 (CTIP2) plays critical roles during ... 2003) Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)- ...
more infohttp://www.jneurosci.org/content/28/3/622.long

Frontiers | Regulation of Adaptive Immune Cells by Sirtuins | EndocrinologyFrontiers | Regulation of Adaptive Immune Cells by Sirtuins | Endocrinology

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... resveratrol has been shown to improve outcomes in two well-characterized murine models of autoimmunity: EAE (80) and colitis ( ... Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate ... Kuroda S, Yamazaki M, Abe M, Sakimura K, Takayanagi H, Iwai Y. Basic leucine zipper transcription factor, ATF-like (BATF) ...
more infohttps://www.frontiersin.org/articles/10.3389/fendo.2019.00466/full
  • Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. (jci.org)
  • Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. (jci.org)
  • Furthermore, inhibition of COUP-TFII preserved SC function and counteracted the muscle weakness associated with Duchenne-like dystrophy in the murine model, suggesting that targeting COUP-TFII is a potential treatment for DMD. (jci.org)
  • Together, our findings reveal a regulatory role of COUP-TFII in the development of muscular dystrophy and open up a potential therapeutic opportunity for managing disease progression in patients with DMD. (jci.org)
  • After the model of eutopic primary cultured endometrial cells of endometiosis and hysteromyoma in vitro was successfully established, the changes of steroidgenic factor-1 (SF-1), chicken ovalbumin upstream-transcription factor (COUP-TF), 17-beta-hydroxysteroid dehydrogenase 1 (17-beta-HSD1) and 17-beta-hydroxysteroid dehydrogenase 2 (17-beta-HSD2) mRNA were detected by RT-PCR before and after treatment of medicated serum of SLW. (readbyqxmd.com)
  • We have discovered PF-8, the processivity factor KSHV that enables the viral DNA polymerase (Pol-8) to remain on the template and incorporate thousands of nucleotides. (upenn.edu)
  • [2] The expression of a gene can also be downregulated by blocking elongation by RNA polymerase (without the need for an effector domain) in the coding region or alternatively, RNA itself can also be targeted. (wikipedia.org)
  • Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K and Yamamoto T (1988) Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (nursa.org)
  • A 2009 study, published under the mentorship of Griffin P. Rodgers, discovered that in human erythrocytes (peripheral blood CD34+ cells), the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can be a crucial molecular mechanism that has the potential for the development of effective pharmacologic strategies for treatment of patients with sickle cell disease or other β-hemoglobinopathies. (wikipedia.org)
  • In addition, a variety of transcription factor families acting downstream of-or in concert with-these signaling networks play vital roles in arteriovenous (AV) specification. (edu.au)
  • We find that the transcription factor Ctip2 (also known as Bcl11b ) is central to MSN differentiation and striatal development. (jneurosci.org)
  • Th2 cells are important for responses to helminthic and other gastrointestinal parasitic infections, producing IL-4, IL-5, and IL-10, and stimulating B cell differentiation ( 2 ). (frontiersin.org)
  • This subset secretes key anti-inflammatory cytokines, notably TGFβ and IL-10, and Treg differentiation is driven by the transcription factor Foxp3. (frontiersin.org)
  • rs143383 is a C to T transition SNP located in the 5′untranslated region (5′UTR) of the growth differentiation factor 5 gene GDF5 . (prolekare.cz)
  • We showed that COUP-TFI is expressed in the stroma and mesenchymal cells at embryonic d 11.5 (E11.5) and expression persists throughout embryonic development. (nih.gov)
  • Specification of arterial, venous, and lymphatic endothelial cells during embryonic development [2] "The groundbreaking discovery about arterial and venous expression of ephrinB2 and EphB4, respectively, in early embryonic development has led to a new paradigm for vascular research, providing compelling evidence that arterial and venous endothelial cells are established by genetic mechanisms before circulation begins. (edu.au)
  • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. (medecinesciences.org)
  • 2010). In retinal pigment epithelium cells of patients suffering from the wet form, but not the dry form, of macular degeneration, TNFalpha represses BMP4 transcription through phosphorylation of the transcription factor Sp1, demonstrating a BMP4 expression-dependent molecular switch (Xu et al. (atlasgeneticsoncology.org)
  • MUC13 also contains 3 epidermal growth factor (EGF)-like domains and a cytoplasmic domain containing potential phosphorylation sites, which could play a role in cell signaling. (aacrjournals.org)
  • We identified a novel class of PP1-targeting compounds that reactivate latent HIV-1 provirus by targeting PP1, increasing CDK9 phosphorylation and enhancing HIV transcription. (biomedcentral.com)
  • Understanding how islet cells sense changes in the concentration of blood glucose is an important question for human health since defective glucose-stimulated insulin release is a contributory factor in non-insulin-dependent diabetes mellitus (NIDDM). (physiology.org)
  • 1992) and insulin like growth factor-1 (IGF-1) synthesis and secretion with gene transcription positively regulated by GH (Hannon et al. (espritrock.org)
  • The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. (ubc.ca)
  • said insulin-sensitive element comprises a nucleotide sequence set forth in SEQ ID NO.: 2. (google.com)
  • Ucp3 is expressed in brown adipose tissue and skeletal muscle and controlled by a transcription factor complex including PPARalpha, MyoD and the histone acetyltransferase p300. (nih.gov)
  • Chemokines are small, structurally related proteins that play a significant role in leukocyte trafficking and are divided into four groups (CXC, CC, C, and CX3C) based on the position of the first two conserved cysteines. (dovepress.com)
  • CCAAT-enhancer-binding proteins (or C/EBPs) are a family of transcription factors that are composed of six members C/EBP α to C/EBP ζ. (bionity.com)
  • We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH (zeige CHDH Antikörper ) patients, particularly those with comorbid congenital heart defects. (antikoerper-online.de)
  • Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. (medecinesciences.org)
  • Western Blot: COUP-TF I/NR2F1 Antibody [NBP2-- Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. (novusbio.com)
  • Moreover, recent studies demonstrated mutual inhibition between PXR and nuclear factor (NF)-κB signaling pathway, providing a potential molecular mechanism that links xenobiotic metabolism and inflammation [ 10 , 11 ]. (mdpi.com)
  • Our research utilises transgenic mouse models and focuses on understanding the molecular role of NRs (coregulators) and how they control metabolism in muscle, fat and the liver in the context of obesity and type 2 diabetes. (edu.au)
  • Molecular Genetics and Metabolism , 74 (1-2), 206-216. (elsevier.com)