A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.
A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The part of the face above the eyes.
A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.
Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.
A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.
Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Educational institutions for individuals specializing in the field of pharmacy.
Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.
Test designed to identify students suitable for admission into a graduate or undergraduate curriculum.
Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.
Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.
Facilities for the preparation and dispensing of drugs.
The surgical removal of one or both testicles.
Unsaturated androstanes which are substituted with one or more hydroxyl groups in any position in the ring system.
Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.
Tumors or cancer of the PROSTATE.
Thiohydantoin benzene derivative.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Established cell cultures that have the potential to propagate indefinitely.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.
A publication issued at stated, more or less regular, intervals.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.
A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. (1/142)

The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/142)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter. (3/142)

Seven mutations in the hepatocyte nuclear factor (HNF)-4alpha gene have been shown to correlate with type 1 maturity-onset diabetes of the young (MODY 1), a monogenic form of type 2 diabetes. Up to now, only the functional properties of two MODY 1 HNF-4alpha mutants, Q268X and V393I, have been investigated to address how the mutations in the HNF-4alpha gene, found by genetic studies, can give rise to impaired activities of mutated HNF-4alpha proteins and can cause this disease. The E276Q mutation results in a nonconservative substitution occurring in the HNF-4alpha E domain, which is involved in dimerization and transactivation activities as well as in protein-protein interactions with other transcription factors or coactivators. Using the mutated human HNF-4alpha2, we have found that, in the absence of chicken ovalbumin upstream promoter transcription factor II (COUP TFII), the E276Q substitution does not significantly affect the dimerization and transactivating activities of HNF-4alpha, at least on the promoters studied herein. On the other hand, in the presence of COUP TFII, the substitution impairs the enhancement of HNF-4-mediated activation of HNF-1 promoter. The impaired synergy between COUP TFII and HNF-4 on the HNF-1 promoter results from an alteration of their interaction. HNF-1 expression plays a crucial role in transactivation of insulin promoter and of numerous genes coding for enzymes involved in glucose homeostasis. Therefore, its downregulation resulting from the E276Q mutation in HNF-4alpha gene most probably impairs the function of pancreatic beta-cells.  (+info)

Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. (4/142)

Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase CYP26. Subsequently in the embryonic retina, CYP26 forms a narrow horizontal boundary between the dorsal and ventral dehydrogenases, creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal and ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns.  (+info)

Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response. (5/142)

Transcription of the L-type pyruvate kinase (L-PK) gene is induced by glucose in the presence of insulin and repressed by glucagon via cyclic AMP. The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs). From ex vivo and in vivo experiments, it appears that USFs are required for correct response of the L-PK gene to glucose, but their expression and binding activity are not known to be regulated by glucose. A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i.e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). Binding of COUP-TFII to the GlRE was confirmed by electrophoretic mobility shift assays, and COUP-TFII-containing complexes were detectable in liver nuclear extracts. Neither abundance nor binding activity of COUP-TFII appeared to be significantly regulated by diets. In footprinting experiments, two COUP-TFII-binding sites overlapping the E boxes were detected. Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. In addition, a mutated GlRE with increased affinity for USF and very low affinity for COUP-TFII conferred a dramatically decreased glucose responsiveness on the L-PK promoter in hepatocytes in primary culture by increasing activity of the reporter gene in low glucose condition. We propose that COUP-TFII could be a negative regulatory component of the glucose sensor complex assembled on the GlRE of the L-PK gene and most likely of other glucose-responsive genes as well.  (+info)

Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (6/142)

The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.  (+info)

HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). (7/142)

The gene for cholesterol 7alpha-hydroxylase (CYP7A1) contains a sequence at nt -149 to -118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) synergistically activate transcription of the CYP7A1 promoter. Transactivation of CYP7A1 by HNF4 in the human hepatoma cell line, HepG2, was enhanced by cotransfection with COUP-TFII or the basal transcription element binding protein (BTEB). HNF4 prepared from rat liver nuclear extracts bound to oligomers homologous to the nt -146 to -134 sequences in electrophoretic mobility shift assays (EMSA), which corresponded to a conserved region containing a direct repeat of hormone response elements spaced by one nucleotide (DR1). The sequences surrounding this DR1 were found to be essential for the HNF4 transactivation. In vitro-translated COUP-TFII was found to bind the adjacent sequences from nt -139 to -128 (DR0), but COUP-TFII interacted with this region at a much lower affinity than to the COUP-TFII-site at nt -72 to -57 (DR4). Mutations at nt -139 to -128 or nt -72 to -57 reduced the COUP-TFII and HNF4 synergy; however, these COUP-TFII-binding sequences were not absolutely required for the cooperative effect of HNF4 and COUP-TFII on transactivation. These results indicated that the observed transactivation was the result of protein/protein interactions facilitated by the juxtaposition of the binding elements.  (+info)

ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. (8/142)

Actin related protein of vertebrate, Arp1, is a major component of the dynactin complex. To characterise and localise Arp1 during mammalian spermatogenesis, polyclonal antibodies were raised against a human recombinant Arp1. Anti-Arp1 antibodies were used for western-immunoblotting, indirect immunofluorescence and immunoelectron microscopy. In round spermatids, Arp1 was detected at the centrosome and at the Golgi apparatus. In elongated spermatids, Arp1 was predominantly found along microtubules of the manchette and at their site of attachment to the nuclear envelope. In maturing spermatids, Arp1 was still present in the pericentriolar material, but in testicular spermatozoa it was not detectable. These various localisations of Arp1 and their changes during spermatid differentiation suggest that the dynactin complex in association with dynein might contribute to several activities: the functional organisation of the centrosome and of the Golgi apparatus and the shaping of the nucleus by manchette microtubules.  (+info)

1. Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metabolism. 2008; 7:86-94. PMCID:PMC2278019. 2. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA. 2008; 105: 2421-2426. PMCID:PMC2268152. 3. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, and Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010. 143; 156-169. PMCID:PMC2950833. 4. Eguchi J, Wang X, Yu S, Kershaw EE, Chui PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, and Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metabolism. 2011; 13: 249-259. PMCID: PMC3063358. 5. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong S-E, and Rosen ED. FOSL2 promotes adipocyte-specific leptin gene ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Gtf2ird1 (untagged) - Mouse general transcription factor II I repeat domain-containing 1 (Gtf2ird1), transcript variant 9, (10ug), 10 µg.
The general transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] Before the start of transcription, the transcription factor II D (TFIID) complex, binds to the core promoter of the gene. TFIID is the first protein to bind to DNA during the formation of the pre-initiation transcription complex of RNA polymerase II (RNA Pol II). Binding of TFIID to the TATA box in the promoter region of the gene initiates the recruitment of other factors required for RNA Pol II to begin transcription. Some of the other recruited transcription factors include TFIIA, TFIIB, and TFIIF. Each of these transcription factors is formed from the interaction of many protein subunits, indicating that transcription is a heavily regulated process. Several of the TFIID subunits have been implicated in core promoter selectivity (Verrijzer and Tijan, 1996; Hampsey and Reinberg, 1997; Smale, 1997; Hahn, 1998).[2] ...
Alias: NR2F2, ARP1, ARP-1, COUP transcription factor II, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, COUPTFII, COUP transcription factor 2, EAR3, NF-E3, SVP40, COUPTF-II, TFCOUP2 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Rheumatoid arthritis (RA) is associated with a high prevalence of atherosclerosis. Recently increased levels of microparticles (MPs) have been reported in patients with RA. MPs could represent a link between autoimmunity and endothelial dysfunction by expressing tumor necrosis factor alpha (TNFα), a key cytokine involved in the pathogenesis of RA, altering endothelial apoptosis and autophagy. The aim of this study was to investigate TNFα expression on MPs and its relationship with endothelial cell fate. MPs were purified from peripheral blood from 20 healthy controls (HC) and from 20 patients with RA, before (time (T)0) and after (T4) 4-month treatment with etanercept (ETA). Surface expression of TNFα was performed by flow cytometry analysis. EA.hy926 cells, an immortalized endothelial cell line, were treated with RA-MPs purified at T0 and at T4 and also, with RA-MPs in vitro treated with ETA. Apoptosis and autophagy were then evaluated. RA-MPs purified at T0 expressed TNFα on their surface and this
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
In the mosquito Aedes aegypti, vitellogenesis is activated via an ecdysteroid hormonal cascade initiated by a blood meal. The functional ecdysone receptor is a heterodimer composed of the ecdysone receptor (EcR) and ultraspiracle, the homolog of the retinoid X receptor. The precise tuning of this hormonal response requires participation of both positive and negative transcriptional regulators. In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor complex-mediated transactivation in vitro and in vivo. Here we report the cloning and characterization of the Svp homolog in mosquito Aedes aegypti, AaSvp. It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. AaSvp transcripts and protein are present in the fat body at high levels from the state of arrest to about 60 h post blood meal. AaSvp binds strongly to a variety of direct repeats of the sequence AGGTCA, but weakly to ...
Sigma-Aldrich offers abstracts and full-text articles by [Jae Hyeon Kim, Jin-Kyu Kim, Eun-Kyung Ahn, Hye-Jin Ko, Young-Rak Cho, Choong Hyun Lee, Yong Kee Kim, Gyu-Un Bae, Joa Sub Oh, Dong-Wan Seo].
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. NR2F6 serves as an antigen receptor signaling threshold-regulated barrier against autoimmunity where NR2F6 is part of a negative feedback loop that limits inflammatory tissue damage induced by weakly immunogenic antigens such as self-antigens. Under such low affinity antigen receptor stimulation, NR2F6 appears as a prototypical repressor that functions to
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
Telescoape astronomice Celestron CGE PRO semiprofesionale SCT clasice si Edge HD pentru observatoare astronomice si cercetare, telescop astronomic Celestron CGE PRO 925 1100 1400 Edge HD
J:244916 Zhao F, Franco HL, Rodriguez KF, Brown PR, Tsai MJ, Tsai SY, Yao HH, Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017 Aug 18;357(6352):717-720 ...
Differentiation of arteries and veins is essential for the development of a functional circulatory system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated the importance of this pathway in driving artery endothelial cell differentiation. However, when and where Notch activation occurs to affect endothelial cell fate is less clear. Using transgenic zebrafish bearing a Notch-responsive reporter, we demonstrate that Notch is activated in endothelial progenitors during vasculogenesis prior to blood vessel morphogenesis and is maintained in arterial endothelial cells throughout larval stages. Furthermore, we find that endothelial progenitors in which Notch is activated are committed to a dorsal aorta fate. Interestingly, some arterial endothelial cells subsequently downregulate Notch signaling and then contribute to veins during vascular remodeling. Lineage analysis, together with perturbation of both Notch receptor and ligand function, further suggests several distinct
LXR α 0h 4h 8h 18h 1D 2D 3D 4D 5D 6D 7D 8D h 2d d Induction MediumDifferentiation Medium NR Expression during Adipogenesis of 3T3-L1 Cells (2) Fu et al., Mol. Endo. 19: 2437 (2005) Nur77 PPAR γ NUR77 LXR  PPAR 
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. Recent research suggests ... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11B has been shown to interact with COUP-TFI. BCL11B is closely connected with immune regulation and for so its mutation can ...
... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11A was initially discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (December 2002). "COUP-TF ( ...
... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ... It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional ...
"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... 2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney". J. Biol. Chem. 276 (16): 13295- ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ... "Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis ...
"Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...
"Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ...
COUP+Transcription+Factor+I at the US National Library of Medicine Medical Subject Headings (MeSH) COUP+Transcription+Factor+II ... There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively. ... COUP+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ...
This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ... The binding sites on the response elements for NR4A1, which are common to the two other members of the NR4A family, are: NBRE ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... Besides these, NR4A1 can mediate T cell function, the transcription factor NR4A1 is stably expressed at high levels in tolerant ...
Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen ... Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hERα-COUP-TFI ... Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ...
Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ... The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ...
"Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ...
Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... COUP-TF *(I. *II. *Ear-2. *HNF4 *α. *γ. *PNR. *RXR *α ... Artificial transcription factor, of which the ZF-TF is a type. ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...
... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide-1-phosphate. This enzyme ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ...
"Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ... "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...
... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... macrophage-activating factors MeSH D12.776.467.374.480.615.350 - interferon type ii MeSH D12.776.467.374.480.625 - macrophage ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ...
第二亚族(COUP-TF(英语:Chicken ovalbumin upstream promoter-transcription factor)(I、II)、Ear-2(英语:V-erbA-related gene)、HNF4(英语: ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... GATA(英语:GATA transcription factor)(1、2、3、4、5、6) · MTA(1、2、3) · TRPS1(英语:Tricho-rhino-phalangeal syndrome Type
Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a ... Tanaka S, Ueo H, Mafune K, Mori M, Wands JR, Sugimachi K (May 2001). "A novel isoform of human fibroblast growth factor 8 is ...
... coup transcription factor i MeSH D12.776.930.682.074.500 - coup transcription factor ii MeSH D12.776.930.682.350.174 - estrogen ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk transcription factor MeSH D12.776.930.127.656.770 - nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk transcription factor MeSH D12.776.930.316.750.770 - nf-e2 ...
... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... The two main phosphorylation sites on Lck are tyrosines 394 and 505. The former is an autophosphorylation site and is linked to ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... In addition to significance of Lck and Fyn in T cell receptor signaling, these two src kinases have also been shown to be ...
... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... In addition, two additional classes, type III which are a variant of type I, and type IV that bind DNA as monomers have also ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally ...
"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, Ishikawa F (December 2002). "MBD3 and HDAC1, two components of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ...
He is the most expressive post-World War II president and with high adverbial intensifiers, he is an actor who displays ... Applied analysts make great use of the psychobiography, while academics tend to analyze transcriptions in search of traits and ... Relate personality to key issues, emphasizing in which direction the psychological factors point. Estimate drives, values, and ... when most leaders of coups emerge), or in old age, when leaders, especially narcissists, feel the reins of power slipping and ...
People Power Revolution 1986-1987 Philippine coup attempts 1989 Philippine coup attempt EDSA Revolution of 2001 Attempted coups ... occupation by the Empire of Japan during World War II and participation in Asian conflicts post-World War II such as the Korean ... "A Complete Transcription of Majapahit Royal Manuscript of Nagarakertagama". Jejak Nusantara (in Indonesian). Cite error: The ... 2001). "Cultural Landmarks and their Interactions with Economic Factors in the Second Millennium in the Philippines". Kinaadman ...
Hawaiian syllable structure is (C)V. All CV syllables occur except for wū;[97] wu occurs only in two words borrowed from ... These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... The decline of the Hawaiian language was accelerated by the coup that overthrew the Hawaiian monarchy and dethroned the ... in making handwritten transcriptions of Hawaiian vowels.[86] The missionaries specifically requested their sponsor in Boston to ...
第二亚族(COUP-TF(I、II)、Ear-2、HNF4(α、γ)、PNR、RXR(α、β、γ)、Testicular receptor(2、4)、TLX). 第三亚族(甾类激素(英语:Steroid hormone receptor)(雄激素、雌激素 ... Handbook of Transcription Factor NF-κB. Boca Raton: CRC. 2006. ISBN 0-8493-2794-6.. ... BBX(英语:BBX (gene)) · HMGB(1(英语:HMGB1)、2(英语:HMGB2)、3(英语:HMGB3)、4(英语:HMGB4)) · HMGN(英语:HMGN)、(1(英语:HMGN1)、2(英语:HMGN2)、3(英语:HMGN3) ... 核因子活化B细胞κ轻链增强子(英語:nuclear factor kappa-light
... politics were not a factor. During World War II, the German military had thousands of its members executed, often for the most ... significantly reducing the coup risk Hitler faced from building an effective army. However, as the successor to a ... Using transcriptions of secret records of conversations among POWs, they conclude that most soldiers were not interested in ... After World War II, a substantial number of the military leaders were called on to testify under oath. Anyone who has studied ...
Roeder RG (1996). „The role of general initiation factors in transcription by RNA polymerase II". Trends Biochem. Sci. 21 (9): ... COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). potfamilija 3 (Steroidni hormon ( ... Transcription Factor Classification, A classification of transcription factors based on their DNA-binding domains". BIOBASE ... Latchman DS (1997). „Transcription factors: an overview". Int. J. Biochem. Cell Biol. 29 (12): 1305-12. PMID 9570129. doi: ...
repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... transcription factor binding. • RNA polymerase II core promoter proximal region sequence-specific DNA binding. • E-box binding ... transcription, DNA-templated. • transcription from RNA polymerase II promoter. • G1/S transition of mitotic cell cycle. • ... regulation of transcription from RNA polymerase II promoter. • protein deubiquitination. • positive regulation of transcription ...
RNA polymerase II transcription regulatory region sequence-specific binding. • RNA polymerase II transcription factor activity ... transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... regulation of transcription from RNA polymerase II promoter. • skeletal system morphogenesis. • transcription, DNA-templated. • ...
COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 (Steroidni hormon ( ... Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1-2): 1-14. PMID ... ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFY (A, B, C) • Ro/Sigma ... ARX • CDX (1, 2) • CRX • CUTL1 • DBX (1, 2) • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox ...
transcription factor binding. • protein domain specific binding. • RNA polymerase II transcription factor activity, sequence- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... transcription, DNA-templated. • spermatogenesis. • positive regulation of transcription from RNA polymerase II promoter. • ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • sequence- ...
... so that both the amino-terminal transcription factor domain and the COOH-terminal regulatory domain face the cytoplasm. The two ... Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... Mammalian genomes have two separate SREBP genes (SREBF1 and SREBF2):. *SREBP-1 expression produces two different isoforms, ... SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ...
RNA polymerase II regulatory region sequence-specific DNA binding. • RNA polymerase II transcription factor activity, ligand- ... transcription corepressor activity. • transcription factor activity, sequence-specific DNA binding. • transcription coactivator ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • nuclear euchromatin. • ... transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. • chenodeoxycholic acid binding. • ...
3 losses over the past two decades have caused a negative forcing of the surface-troposphere system"[24] of about −0.15 ± 0.10 ... Gunkel, Christoph (September 13, 2013). "Öko-Coup aus Ostdeutschland". Der Spiegel (in German). Retrieved 4 September 2015.. ... Another factor that may prolong ozone depletion is the drawdown of nitrogen oxides from above the stratosphere due to changing ... resulting in transcription errors when the DNA replicates. These cancers are relatively mild and rarely fatal, although the ...
Chaffee, John W. (2015), The Cambridge History of China Volume 5 Part Two Sung China, 960-1279, Cambridge University Press. ... The officials who gained power by succeeding in the imperial examination became a leading factor in the shift from a military- ... out of fear that Emperor Gong would stage a coup to restore his reign.[58] Other members of the Song Imperial Family continued ... Haw, Stephen G. (2013). "The deaths of two Khaghans: a comparison of events in 1242 and 1260". Bulletin of the School of ...
a b History of Mongolia, Volume II, 2003. *^ Shurkhuu, D. (2014). "Similarities and Differences between Mongolia and Tuva in ... This unsettled the Kremlin, which orchestrated a coup carried out in 1929 by five young Tuvan graduates of Moscow's Communist ... Then, Tuva was administered as part of Outer Mongolia, and the language difference was a determining factor in Tuva seeking ... Two religions are widespread among the people of Tuva: Tibetan Buddhism and shamanism. Tibetan Buddhism's present-day spiritual ...
RNA polymerase II transcription factor activity, sequence-specific DNA binding. • RNA polymerase II distal enhancer sequence- ... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is ... RNA polymerase II core promoter proximal region sequence-specific DNA binding. • chromatin binding. • transcription factor ...
transcription factor activity, RNA polymerase II transcription factor recruiting. • RNA polymerase II transcription factor ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... transcription, DNA-templated. • positive regulation of transcription from RNA polymerase II promoter. • positive regulation of ... transcription from RNA polymerase II promoter. • mitotic cell cycle. • response to hypoxia. • positive regulation of collagen ...
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is ... positive regulation of transcription from RNA polymerase II promoter by glucose. • regulation of transcription from RNA ...
The decoration of two cranes on his chest is a "rank badge" that indicates he was a civil official of the first rank. ... Dardess, John W. (1968), Background Factors in the Rise of the Ming Dynasty, Columbia University.. ... On 7 August 1461, the Chinese general Cao Qin and his Ming troops of Mongol descent staged a coup against the Tianshun Emperor ... Transcriptions. Standard Mandarin. Hanyu Pinyin. Dà Míng Dì Guó. Wade-Giles. Ta Ming Ti Kuo. ...
COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 (Steroidni hormon ( ... "A phylogenomic analysis of bacterial helix-turn-helix transcription factors.". FEMS Microbiol Rev 33 (2): 411-29. PMID 19076237 ... ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFY (A, B, C) • Ro/Sigma ... ARX • CDX (1, 2) • CRX • CUTL1 • DBX (1, 2) • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox ...
transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ... positive regulation of transcription from RNA polymerase II promoter. • suckling behavior. • regulation of tissue remodeling. • ... transcription regulatory region DNA binding. Cellular component. • transcription factor complex. • protein complex. • nuclear ... In addition, this transcription factor plays an important role in limb and branchial arch development.[6] In one study, it was ...
transcription factor complex. • RNA polymerase II transcription factor complex. • Ядерце. • клітинне ядро. • nucleoplasm. • ... GO:0001105 transcription coactivator activity. • transcription factor binding. • GO:0000980 RNA polymerase II cis-regulatory ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... transcription from RNA polymerase II promoter. • cellular response to tumor necrosis factor. • positive regulation of DNA- ...
repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. • transcription ... positive regulation of transcription from RNA polymerase II promoter. • transcription initiation from RNA polymerase II ... RNA polymerase II repressing transcription factor binding. • protein binding. • recombinase activity. • chromatin binding. • ...
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • GO:0001078, GO: ... regulation of transcription from RNA polymerase II promoter. • negative regulation of transcription from RNA polymerase II ... GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity. • ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • ...
RNA polymerase II transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence- ... negative regulation of transcription from RNA polymerase II promoter. • mesonephric duct morphogenesis. • transcription, DNA- ... OSR1, ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ...
0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • transcription factor activity, RNA polymerase ... RNA polymerase II regulatory region sequence-specific DNA binding. • RNA polymerase II transcription factor binding. • GO: ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... transcription from RNA polymerase II promoter. • positive regulation of transcription from RNA polymerase II promoter. • aortic ...
0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • GO:0001105 transcription coactivator activity ... 0001204 DNA-binding transcription factor activity. • 5'-deoxyribose-5-phosphate lyase activity. • transcription factor binding ... transcription, DNA-templated. • transcription by RNA polymerase II. • nuclear transport. • GO:0022415 viral process. • base- ... "Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y ...
RNA polymerase II transcription factor binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • metanephros development ... negative regulation of sequence-specific DNA binding transcription factor activity. • regulation of transcription, DNA- ...
... the domain in winged-helix transcription factors (see Regulation of gene expression) has four helices and a two-strand beta- ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
RNA polymerase II core promoter proximal region sequence-specific DNA binding. • RNA polymerase II transcription factor ... positive regulation of transcription from RNA polymerase II promoter. • transcription from RNA polymerase II promoter. • ... MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1. ... regulation of transcription, DNA-templated. • regulation of transcription from RNA polymerase II promoter. • response to metal ...
RNA polymerase II-specific. • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II- ... positive regulation of transcription from RNA polymerase II promoter. • transcription, DNA-templated. • transcription from RNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... regulation of transcription, DNA-templated. • organ induction. • anterior/posterior pattern specification. • ...
transcription corepressor activity. • metal ion binding. • nucleic acid binding. • RNA polymerase II transcription factor ... negative regulation of transcription from RNA polymerase II promoter. • negative regulation of intracellular estrogen receptor ... DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. ... it was shown that DC-SCRIPT can act as a coregulator of multiple nuclear receptors having opposite effects on type I vs type II ...
see also transcription factor/coregulator deficiencies. This article on a gene on the human X chromosome and/or its associated ... COUP-TF *(I. *II. *Ear-2. *HNF4 *α. *γ. *PNR. *RXR *α ... a new member of the Hmg1/2 gene family". Genomics. 49 (2): 247- ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • DNA geometric change. • negative regulation of B ...
RNA polymerase II core promoter sequence-specific DNA binding. • transcription factor activity, RNA polymerase II core promoter ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... negative regulation of transcription from RNA polymerase II promoter. • transcription from RNA polymerase II promoter. • ... Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription ...
GO:0003700 DNA-binding transcription factor activity GO:0003707 steroid hormone receptor activity GO:0004879 nuclear receptor ...
Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... COUP transcription factor 2Add BLAST. 414. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter.". Huggins G.S., ...
NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Starting at: $796.00. *Model: ELI-25413b ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Product Name:Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Packing: ... Target Protein Name:Bovine COUP transcription factor 2, NR2F2 Alternative Name:NR2F2,Bovine COUP transcription factor 2, NR2F2 ...
positive regulation of transcription by RNA polymerase II Source: Ensembl. *transcription, DNA-templated Source: UniProtKB- ... COUP transcription factor 1Imported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,Q32NY6,Q32NY6_MOUSE COUP transcription factor 1 OS=Mus musculus OX=10090 GN=Nr2f1 PE=1 SV=1 ... Transcription, Transcription regulationPROSITE-ProRule annotation. ,p>Information which has been generated by the UniProtKB ...
View Mouse Monoclonal anti-COUP-TF II/NR2F2 Antibody (H7147) [Unconjugated] (PP-H7147-00). Validated Applications: WB, IHC, IP ... Chicken ovalbumin upstream promoter transcription factor II (COUP-TF II, ARP-1, COUP-TFB; NR2F2) is a member of the orphan ... Blogs on COUP-TF II/NR2F2. There are no specific blogs for COUP-TF II/NR2F2, but you can read our latest blog posts. ... PTMs for COUP-TF II/NR2F2 Antibody (PP-H7147-00). Learn more about PTMs related to COUP-TF II/NR2F2 Antibody (PP-H7147-00). ...
COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a ... 09/01/2010 - "Here, we review the emerging role(s) of orphan nuclear receptors in breast cancer, with a particular focus on two ... COUP Transcription Factors. Subscribe to New Research on COUP Transcription Factors A sub-family of steroid receptor-related ...
... our data suggest the role of these two variants in the et … ... COUP Transcription Factor II / genetics * DNA-Binding Proteins ... Nori Matsunami 1 , Hari Shanmugam 2 , Lisa Baird 1 , Jeff Stevens 1 , Janice L Byrne 3 , Douglas C Barnhart 4 , Carrie Rau 2 , ... CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. Although recent studies ... aka COUP-TFII), generating a premature truncation of the protein. This patient also carried a missense variant predicted to be ...
IPR003068 Transcription factor COUP. IPR013088 Zinc finger, NHR/GATA-type. IPR001628 Zinc finger, nuclear hormone receptor-type ... J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2): ... J:215426 Ichim CV, et al., The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development. Exp ... 1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus. ...
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AGPAT3 Gene ... Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] See more... ... Transcription Factor. Binding Sites. Gene Targets. GH21J043863. Promoter/Enhancer. 2.2. EPDnew Ensembl ENCODE CraniofacialAtlas ... Top Transcription factor binding sites by QIAGEN in the AGPAT3 gene promoter:. *ATF-2 ...
Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li,6: V-erbA-related ... COUP /EAR ,/li,,/ul,,ul,,ul,,li,1: Chicken ovalbumin upstream promoter-transcription factor I ( COUP-TFI ; NR2F1 ) ,/li,,/ul,,/ ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ...
Università degli Studi di Napoli Federico II. Department:. Biologia strutturale e funzionale. ... Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical ... The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and ... Romano, Anna Lisa (2013) Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis ...
Rabbit recombinant monoclonal COUP TF1 antibody [EPR10841] conjugated to Alexa Fluor® 647. Validated in ICC/IF and tested in ... transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation ... Alexa Fluor® 555 Anti-COUP TF1 antibody [EPR10841] (ab211712) *Anti-COUP TF1 antibody [EPR10841] - BSA and Azide free (ab224272 ... Alexa Fluor® 647 Anti-COUP TF1 antibody [EPR10841]. See all COUP TF1 primary antibodies. ...
"Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, OMalley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...
SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.. Aerbajinai W, Zhu J, ... The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.. Chin KL, Aerbajinai W ... Glia maturation factor-γ mediates neutrophil chemotaxis.. Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.. J Leukoc ... Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.. Aerbajinai W, Liu L, Zhu J, Kumkhaek ...
COUP transcription factor 2 Show on y-axis - References (HTP + LTP). References (LTP). References (HTP). Mutation Frequency in ...
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
Top Transcription factor binding sites by QIAGEN in the MAG gene promoter:. *COUP ... No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MAG Gene ... Transcription Factor. Binding Sites. Gene Targets. GH19J035293. Enhancer. 1. FANTOM5 Ensembl dbSUPER 634.4. +1.8. 1776. 1.7. ... 2. ^. 3a. ·. 3b. ·. 3c. ^. 4a. ·. 4b. ·. 4c. ·. 4d. ^. 5. ^. 6a. ·. 6b. ·. 6c. ^. 7. ^. 8. ^. 9a. ·. 9b. ^. 10a. ·. 10b. ^. 11 ...
COUP-TF1, chicken ovalbumin upstream promoter-transcription factor 1; CTL, cytotoxic T-lymphocyte; EDEM, ER degradation- ... Abbreviations: BiP, immunoglobulin heavy-chain-binding protein; CaMKII, Ca2+/calmodulin-dependent protein kinase II; C/EBP, ... nuclear factor of activated T-cells; Nkx2.5, NK2 transcription factor related, locus 5; PACS-2, phosphofurin acidic cluster ... transforming growth factor; TSP-1, thrombospondin 1; UGGT, UDP-glucose:glycoprotein transferase ...
Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment ... Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. J ... Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005;310(5748):644-648.. View this ... In addition, since NCoA2 does not directly bind to DNA, it is currently unclear which transcription factor(s) cooperates with ...
COUP transcription factor II, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, COUPTFII, COUP transcription factor 2, EAR3, NF-E3, ... COUP transcription factor II, Nuclear receptor subfamily 2 group F member 2 ... Protein Name: COUP transcription factor 2 Alias: NR2F2, ARP1, TFCOUP2, COUP transcription factor 2, Apolipoprotein A-I ... Protein Name: COUP transcription factor 2 Alias: NR2F2, ARP1, ARP-1, ...
COUP-TF, chicken ovalbumin upstream promoter transcription factor; EAR-2, v-erbA-related; NURR1, NR-related 1; NOR1, neuron- ... Mammalian Two-Hybrid Assay. The mammalian two-hybrid system (Promega) consists of VP16-hPXR (wild-type or mutant), Gal4-SRC-1, ... Tang ED, Nuñez G, Barr FG, and Guan KL (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem ... Pregnane X receptor (PXR) is a member of the nuclear receptor (NR) family of ligand-activated transcription factors and is ...
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation ... Alternate Names for COUP-TF I/NR2F1 Antibody. *COUP transcription factor 1 ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ...
Expression level of Coup-TFII and Ucp3 mRNA in tissues of P. sungorus. Coup-TFII mRNA is expressed in all examined tissue types ... Several studies have demonstrated interaction of these factors with chicken ovalbumin upstream promoter transcription factor II ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ...
The nuclear receptor chicken ovalbumin upstream promoter-transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult ... COUP-TFII regulates mouse Amhr2 gene transcription in MA-10 Leydig cells. (A) Depletion of COUP-TFII in MA-10 Leydig cells ... 1 transcription factor. COUP-TFII transcriptionally cooperates with SP1 on the Amhr2 promoter. Mutations that altered the ... supporting an additional role in steroidogenesis for this transcription factor. COUP-TFII action in Leydig cells remains to be ...
... identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor ... suggesting that targeting COUP-TFII is a potential treatment for DMD. Together, our findings reveal a regulatory role of COUP- ... regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC function and counteracted the ... Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated ...
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse ... As the two phenotypes are not identical, a cross-repression between the two receptors appears to be unlikely. The sequential ... It will greatly improve our understanding of transcription factors, like RORα and TRα1, which are already well known to be ... suggesting that several of the small ligand molecules that bind these transcription factors are required locally. We have ...
2002) COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific ... 4M,M′), usually with only one or two large areas of dense staining in the subcallosal streak (Fig. 4N,N′). These data indicate ... We demonstrated previously that the transcription factor COUP TF1-interacting protein 2 (CTIP2) plays critical roles during ... 2003) Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)- ...
COUP-TF I explanation free. What is COUP-TF I? Meaning of COUP-TF I medical term. What does COUP-TF I mean? ... Looking for online definition of COUP-TF I in the Medical Dictionary? ... COUP transcription factor I. *COUP transcription factor II. *Coup-detat. *Coup-detat ... redirected from COUP-TF I) NR2F1. A gene on chromosome 5q14 that encodes a transcription factor that binds to the ovalbumin ...
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... resveratrol has been shown to improve outcomes in two well-characterized murine models of autoimmunity: EAE (80) and colitis ( ... Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate ... Kuroda S, Yamazaki M, Abe M, Sakimura K, Takayanagi H, Iwai Y. Basic leucine zipper transcription factor, ATF-like (BATF) ...
Renin gene expression is regulated by Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TF II). Joint Annual ... Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) mediated downregulation of arterial transcription ... Glucose-dependent regulation of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) in human endothelial ... Impact of growth factors, shear stress and transcription factor COUP-TFII on the Notch pathway in human endothelial cells. ...
  • Although the majority of these genes are not known to be associated with CDH, one patient with CDH and cardiac anomalies harbored a frameshift mutation in NR2F2 (aka COUP-TFII), generating a premature truncation of the protein. (nih.gov)
  • Two transcript variants encoding the same protein have been found for this gene. (genecards.org)
  • COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. (wikipedia.org)
  • Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. (wikipedia.org)
  • Recombinant protein encompassing a sequence within the center region of human COUP TF1. (novusbio.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Gene reporter, Western blotting, immunocytochemistry, mammalian two-hybrid, and electrophoretic mobility shift assays were used to study cytochrome P450 3A4 ( CYP3A4 ) promoter activation, protein levels, localization, cofactor interaction, and CYP3A4 promoter binding of the hPXR mutants, respectively. (aspetjournals.org)
  • Similar to steroid receptors, the N-terminal part of the PXR protein contains a highly conserved DNA binding domain (DBD) ( Fig. 1A ), and the C-terminal part of the protein contains a ligand binding domain (LBD) with an additional ligand-inducible transactivation function 2 (AF-2). (aspetjournals.org)
  • Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. (nih.gov)
  • Even though the -67/-34 bp region contains an imperfect nuclear receptor element, COUP-TFII-mediated activation of the Amhr2 promoter requires a GC-rich sequence at -39 bp known to bind the specificity protein (SP)1 transcription factor. (nih.gov)
  • Insufficiency of RAN-binding protein-2 (RANBP2), a large, mosaic protein with pleiotropic functions, suppresses apoptosis of photoreceptor neurons upon aging and light-elicited oxidative stress, and promotes age-dependent tumorigenesis by mechanisms that are not well understood. (nih.gov)
  • In the absence of the NICD, the RBPJ protein binds to specific DNA sequences in the regulatory elements of various target genes and represses transcription of these genes by recruiting histone deacetylases and other components to form a co-repressor complex. (biologists.org)
  • A common feature of the members of this protein family is the presence of a conserved domain in the carboxyterminal part of the protein, which has the capacity to bind ligands (ligand-binding domain: LBD) modulating the transcriptional activity of the receptor and which folds as an antiparallel alpha-helical sandwich [ 2 ]. (hindawi.com)
  • We've shown that the E1A-12 protein mediates this effect by altering the binding of two transcription factors (NF-kB and COUP-TF) to the class I enhancer which, in turn, blocks transcription from the class I promoter. (upenn.edu)
  • The E1A-5 protein of adenovirus contains a 46 amino acid transactivating domain that stimulates promoters by serving as a bridge between the basal transcription complex and upstream factor binding sites. (upenn.edu)
  • A zinc finger within the transactivating domain binds to the TATA box binding protein (TBP) and a newly discovered cellular factor, hSur-2 (a subunit of human mediator complex), while residues flanking the zinc finger associate with other basal transcription factors, referred to as TAFs. (upenn.edu)
  • In addition, we discuss relatively novel chemical genetic studies of zebrafish vascular development that have provided evidence that a crosstalk between 2 ubiquitous signaling pathways, the phosphoinositide 3-kinase (PI3K) and the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathways, plays a central antagonistic role in artery-vein specification during vasculogenesis. (ahajournals.org)
  • Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)
  • Zusätzlich bieten wir Ihnen Nuclear Receptor Subfamily 2, Group F, Member 6 Antikörper (95) und Nuclear Receptor Subfamily 2, Group F, Member 6 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Sato, Suzuki, Hidaka, Sato, Ito, Ito, Sasano: Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle. (antikoerper-online.de)
  • Protein binding to the gene was investigated by two experimental approaches: 1) competition and supershift electrophoretic mobility shift assays (EMSAs) and 2) an oligonucleotide pull down assay followed by quantitative mass spectrometry. (prolekare.cz)
  • Previous studies using chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (Ctip2) knockout mice have demonstrated the importance of this transcription factor for the formation of the epidermal permeability barrier. (elsevier.com)
  • Bollag, WB 2013, ' COUP-TF-interacting protein-2 (Ctip2): Driving the coupé of sphingolipid biosynthesis in the epidermis ', Journal of Investigative Dermatology , vol. 133, no. 3, pp. 593-594. (elsevier.com)
  • Terminal differentiation is characterized by the induction of metabolic genes, many of which are the direct targets of the transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and C/CAAT-binding protein (C/EBP) α and β ( 8 - 14 ). (pnas.org)
  • Zinc finger protein 423 (Zfp423) is a critical preadipocyte factor upstream of PPARγ that is not present in non-adipogenic fibroblasts ( 17 ). (pnas.org)
  • 2001). Jak2 protein can then phosphorylate signal transducer and activator of transcription (STAT5B) a DNA binding protein which following translocation to the nucleus binds to interferon-gamma-activated sites (GAS) increasing transcription (Lucy et al. (espritrock.org)
  • The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. (thermofisher.com)
  • Nevertheless, the analyses of transcripts suggest alternative forms(see Figure 2 and the Protein tab, under Isoforms). (ubc.ca)
  • 2 , 3 Chemokine receptors are a family of G protein-coupled cell surface receptors (GPCRs) with seven transmembrane-spanning domains. (dovepress.com)
  • Product Description:Bovine COUP transcription factor 2, NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. (lifescience-market.com)
  • Only those wells that contain Bovine COUP transcription factor 2, NR2F2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (lifescience-market.com)
  • The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm.The concentration of Bovine COUP transcription factor 2, NR2F2 in the samples is then determined by comparing the O.D. of the samples to the standard curve. (lifescience-market.com)
  • There are currently no images for COUP-TF II/NR2F2 Antibody (PP-H7147-00). (novusbio.com)
  • Since NR2F2 null mice exhibit a diaphragmatic defect, and XIRP2 is implicated in cardiac development, our data suggest the role of these two variants in the etiology of CDH, and possibly cardiac anomalies. (nih.gov)
  • The nuclear receptor chicken ovalbumin upstream promoter-transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii / Nr2f2 gene impedes their differentiation. (nih.gov)
  • We provide evidence that Coup-TF1 and Coup-TF2 ( Nr2f1 and Nr2f2 ) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST + CINs. (biologists.org)
  • Auf www.antikoerper-online.de finden Sie aktuell 73 Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2) Antikörper von 16 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Studied the role of Nuclear receptor subfamily 2 group F member 2 (NR2F2 ) in MSC (zeige MSC Antikörper ) chondrogenesis in bioprinted cartilage. (antikoerper-online.de)
  • NR2F2 (nuclear receptor subfamily 2, group F, member 2), NR2F1 and NR2F6 are human members of Subfamily 2/Group F of nuclear receptors according to the Unified Nomenclature System [14] . (ubc.ca)
  • COUP-TFs were shown to interact with a number of other nuclear receptors. (novusbio.com)
  • Both CD4 + and CD8 + T cells exist as a number of subsets that perform unique functions within the immune milieu and exhibit unique surface receptors, produce lineage-specific cytokines, and express lineage-defining transcription factors. (frontiersin.org)
  • Among the nuclear orphan receptors affected by insufficiency of RANBP2, we identified an isoform of COUP-TFI (Nr2f1) as the only receptor stably co-associating in vivo with RANBP2 and distinct isoforms of UBC9. (nih.gov)
  • In addition to COUP-TFs, we also examined the expression profiles of eight other nuclear receptors (farnesoid X receptor, vitamin D receptor, hepatocyte nuclear factor 4alpha, retinoid X receptor alpha, mineralocorticoid receptor, steroidogenic factor 1, liver receptor homolog-1, and germ cell nuclear factor). (nih.gov)
  • Noticeably, this domain harbors a ΦΦXEΦΦ motif in its carboxyterminal portion, which is required for ligand-dependent transcriptional activation (AF-2) in other ligand-binding nuclear receptors and lies inside a structured alpha helix (helix H12) [ 2 ]. (hindawi.com)
  • An unusually large ligand-binding pocket is a distinguishing feature of PPARγ and two related receptors, PPARα and PPARβ (also known as PPARδ), which allows these receptors to interact with diverse chemical ligands including various fatty acids, fibrates, and the thiazolidinedione class of antidiabetic drugs. (sciencemag.org)
  • Small-molecule ligands are critical for determining the specificity and activity of most nuclear receptors, because ligand binding induces receptor conformational changes that affect the recruitment of coactivators or co-repressors, a key mechanism for regulating target gene expression ( 2 ). (sciencemag.org)
  • PPARγ and two related receptors, PPARα and PPARβ (also known as PPARδ), form a subfamily of nuclear receptors that play key roles in lipid and glucose metabolism ( 5 - 7 ). (sciencemag.org)
  • Similar to the activation of other nuclear receptors, PPARγ activation depends on the conformation of its C-terminal activation function-2 (AF-2) helix (the red helix in Fig. 1B ). (sciencemag.org)
  • Type II nonsteroid nuclear receptors include the thyroid hormone receptors (TRα and β), retinoic acid receptors (RARα, β, and γ), vitamin D receptor (VDR), and peroxisome proliferator-activated receptors (PPARα, β, and γ). (cellsignal.com)
  • Most of these receptors regulate transcription by binding to their target DNA elements either as monomers or homodimers and recruiting chromatin modifying coactivators and the transcription machinery. (cellsignal.com)
  • We have also extended our previous observations by showing that a sequence containing an E-box was not only bound by USF proteins but also recognized by COUP-TF orphan receptors. (bioone.org)
  • Crystallographic structure of a heterodimer of the nuclear receptors PPAR-γ (green) and RXR-α (cyan) bound to double stranded DNA (magenta) and two molecules of the NCOA2 coactivator (red). (gutenberg.org)
  • Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors . (gutenberg.org)
  • [2] [3] The regulation of gene expression by nuclear receptors generally only happens when a ligand - a molecule that affects the receptor's behavior - is present. (gutenberg.org)
  • A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. (bvsalud.org)
  • Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A). (omeka.net)
  • Overall, these data strongly suggest a molecular cross-regulation between COUP-TFI and Pax6 during the maintenance of a proper balance between the stem/ progenitor and committed precursor pools, most probably acting on similar target genes. (unina.it)
  • Given the substantial evidence for a function of Ucp3 in lipid metabolism, Coup-TFII may not only be a negative regulator of glucose responsive genes but also transactivate genes involved in lipid metabolism. (nih.gov)
  • Given that both hypothalamus and amygdala have overlapping functions, but their CRH-expressing neurons may respond differently to a given perturbation, we sought to identify differentially expressed genes between two neuronal cell types, amygdalar AR-5 and hypothalamic IVB cells. (biomedcentral.com)
  • Of the 10,572 genes, 2,320 genes in AR-5 were expressed at ≥ 2-fold relative to IVBs, 1,104 genes were expressed at ≥2-fold in IVB relative to AR-5 and 7,148 genes were expressed at similar levels between the two cell lines. (biomedcentral.com)
  • The differentially expressed mitochondrial genes were cytochrome b (MT-CYB), cytochrome c oxidase subunit 1 and 2 (MT-CO1 and MT-CO2) and NADH-ubiquinone oxidoreductase chain 1, 2, and 3 (MT-ND1, MT-ND2, MT-ND3). (biomedcentral.com)
  • however the greatest difference between the two cell lines was in genes encoded by the mitochondrial genome. (biomedcentral.com)
  • NR1I2), a member of the nuclear receptor superfamily, primarily expressed in the liver and intestine [ 1 ], has a major role in the induction of genes involved in drug and xenobiotic transport and metabolism [ 2 ], thus preventing the accumulation of toxic chemicals in the body. (mdpi.com)
  • The nuclear receptor and ligand complexes can then bind directly to DNA and activate the transcription of genes involved in a broad spectrum of physiological processes, ranging from development and differentiation to metabolism ( 1 ). (sciencemag.org)
  • The next group of genes is common to liver, adipose tissue, and (in the case of two of them) to islet β-cells. (physiology.org)
  • In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. (semanticscholar.org)
  • Genome-wide strategies identify downstream target genes of chick connective tissue-associated transcription factors. (semanticscholar.org)
  • In Xenopus embryos, BMP4 itself, along with the homeobox genes Vox, X-vent1, X-vent2, GATA-1 , GATA-2 and AP-1 were found to induce the expression of BMP4 and control dorsoventral patterning in the mesoderm (Jones et al. (atlasgeneticsoncology.org)
  • We show that nuclear COUP-TFII expression in fetal rat LC relates inversely to LC expression of steroidogenic factor-1 (SF-1)-dependent genes (StAR, Cyp11a1, Cyp17a1) with overlapping binding sites for SF-1 and COUP-TFII in their promoter regions, but does not affect an SF-1 dependent LC gene (3β-HSD) without overlapping sites. (qub.ac.uk)
  • We then combined sequence and co-expression data in order to identify the transcription factors responsible for regulating genes within their respective communities. (biomedcentral.com)
  • Here we report that the transcriptional repressor transcription factor 7-like 1 (TCF7L1) binds and directly regulates the expression of cell structure genes. (pnas.org)
  • These studies revealed the existence of transcriptional regulatory loops among ERRα, PROX1, and BMAL1, as well as extensive overlaps in their target genes, implicating these three factors in the control of clock and metabolic gene networks in the liver. (prolekare.cz)
  • Genes encoding different α- and β-polypeptide chains are located in two multigene clusters on different chromosomes. (springer.com)
  • The phenomenon of stage-specific transcription of globin genes is referred to as globin gene switching. (springer.com)
  • Mechanisms of expression switching, stage-specific activation, and repression of transcription of α- and β-globin genes are of interest from both theoretical and practical points of view. (springer.com)
  • For arterial specification, vascular endothelial growth factor (VEGF) induces expression of Notch signaling genes, including Notch1 and its ligand, Delta-like 4 (Dll4), and Foxc1 and Foxc2 transcription factors directly regulate Dll4 expression. (edu.au)
  • Upon activation of Notch signaling, the Notch downstream genes, Hey1/2 in mice or gridlock in zebrafish, further promote arterial differentiation. (edu.au)
  • On the other hand, the orphan nuclear receptor COUP-TFII is a determinant factor for venous specification by inhibiting expression of arterial specific genes, including Nrp1 and Notch. (edu.au)
  • It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL. (bvsalud.org)
  • 2) Studying expression of schizophrenia susceptibility genes in the early fetal human thalamus and cerebral cortex. (ncl.ac.uk)
  • To clone and identify the proteins involved in regulating the transcription of hTERT and study the role of genes in both hTERT transcription and telomerase activity. (bvsalud.org)
  • Western Blot: COUP-TF I/NR2F1 Antibody [NBP2-15974] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. (novusbio.com)
  • Several studies have demonstrated interaction of these factors with chicken ovalbumin upstream promoter transcription factor II (Coup-TFII). (nih.gov)
  • In reporter gene assays Coup-TFII enhanced transactivation of the Ucp3 promoter conveyed by MyoD, PPARalpha, RXRalpha and/or p300. (nih.gov)
  • Two TATA-like boxes ( bold ) can only be found in the human promoter. (nih.gov)
  • The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells. (nih.gov)
  • Consistent with this, COUP-TFII directly activates a -1486 bp fragment of the mouse Amhr2 promoter in transient transfection assays. (nih.gov)
  • Chromatin immunoprecipitation assay confirmed COUP-TFII recruitment to the proximal Amhr2 promoter whereas DNA precipitation assay revealed that COUP-TFII associates with the -67/-34 bp region in vitro . (nih.gov)
  • COUP-TFII transcriptionally cooperates with SP1 on the Amhr2 promoter. (nih.gov)
  • Mutations that altered the GCGGGGCGG sequence at -39 bp abolished COUP-TFII-mediated activation, COUP-TFII/SP1 cooperation, and reduced COUP-TFII binding to the proximal Amhr2 promoter. (nih.gov)
  • Our data provide a better understanding of the mechanism of COUP-TFII action in Leydig cells through the identification and regulation of the Amhr2 promoter as a novel target. (nih.gov)
  • B) COUP-TFII activates the mouse Amhr2 promoter in MA-10 Leydig cells. (nih.gov)
  • MA-10 Leydig cells were cotransfected with either 100 ng of an empty expression vector (control, open bars) or an expression vector for COUP-TFII (filled bars), along with 400 ng of Amhr2 promoter construct (−1486/+77 bp or −34/+77 bp, as indicated). (nih.gov)
  • Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. (jci.org)
  • A gene on chromosome 5q14 that encodes a transcription factor that binds to the ovalbumin promoter and, in conjunction with S300-II, stimulates initiation of transcription. (thefreedictionary.com)
  • Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. (sciencemag.org)
  • As a prototype for our analysis, we investigated the expression patterns of chicken ovalbumin upstream promoter transcription factor (COUP-TF) -I and -II in more details during embryonic development and in the adult by immunohistochemistry. (nih.gov)
  • The receptor transactivation domain is responsible for interaction at the promoter with co-activators such as acetyltransferases and the general transcription machinery, resulting in transcriptional activation. (cellsignal.com)
  • 1993). The presence of dual promoter regions flanking exons I and II were later confirmed in human cancer cell lines (van den Wijngaard et al. (atlasgeneticsoncology.org)
  • 1996). Mouse BMP4 is negatively regulated by direct binding of chicken ovalbumin upstream-transcription factor I (COUP-TF1) to the proximal promoter of exon I (Feng et al. (atlasgeneticsoncology.org)
  • 1995). Deletion analysis of the mouse BMP4 promoter in MC3T3E1 cells identified a cis-acting E-box element proximal to the transcriptional start site that is bound by upstream regulatory factor ( USF ), a member of the helix-loop-helix family of regulatory proteins (Ebara et al. (atlasgeneticsoncology.org)
  • We identify a potentially important role for Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) in Leydig cell (LC) steroidogenesis that may partly explain this. (qub.ac.uk)
  • 1998). Three promoters are involved in the control of GHR mRNA UTR 5′ transcription variants, GHR promoter 1 and GHR 1A, GHR P2 and P3 control GHR 1B and 1C. (espritrock.org)
  • Gel mobility shift and antibody supershift assays demonstrated that nuclear factors c-Fos/c-Jun, steroidogenic factor-1 (SF-1), upstream stimulatory factor-1/2 (USF-1/2), and chicken ovalbumin upstream promoter transcription factor-1/2 (COUP-TFI/II) potentially bound to RE-3. (bioone.org)
  • Cell type specific regulation of COUP-TF II promoter activity. (ubc.ca)
  • Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines. (ubc.ca)
  • 6 Two important regulatory domains include the promoter found in the 1.2-kb region immediately upstream of the first exon and an enhancer found immediately downstream of the second polyadenylation site in the 3′ flanking region. (ahajournals.org)
  • The full cDNA of COUP-TFII was cloned from HeLa cDNA library by hTERT promoter-based yeast one- hybrid assay and then in-frame inserted into His-tag fusion expression vector pEK318. (bvsalud.org)
  • The interaction of COUP-TFII with hTERT promoter in vitro was identified by electrophoretic mobility shift assay and Footprint. (bvsalud.org)
  • COUP-TFII could firmly bind to the downstream E-box and the other two binding sites in hTERT promoter. (bvsalud.org)
  • Luciferase reporter assay indicated COUP-TFII could suppress hTERT promoter activity and stable introduction of COUP-TFII into HeLa cells also decreased both endogenous hTERT transcription and telomerase activity. (bvsalud.org)
  • The human COUP-TFII can firmly bind to hTERT promoter, and inhibit telomerase activity through decreasing hTERT transcription. (bvsalud.org)
  • This, in turn, initiates a complex signaling cascade of stress-inducible proteins and transcription factors that serves to return the cell to homeostatic conditions. (biomedcentral.com)
  • The extracellular domain of Notch family proteins contains up to 36 tandemly repeated copies of an epidermal growth factor (EGF)-like motif. (biologists.org)
  • In Drosophila , two decades of work have revealed a network of sequentially expressed transcription factors and RNA-binding proteins that compose a neural progenitor-intrinsic temporal patterning system. (biologists.org)
  • Remember, transcription factors can interact with hundreds of different binding sites to regulate hundreds of different proteins. (blogspot.com)
  • Chemokines are small, structurally related proteins that play a significant role in leukocyte trafficking and are divided into four groups (CXC, CC, C, and CX3C) based on the position of the first two conserved cysteines. (dovepress.com)
  • The His-tag COUP-TFII fusion proteins were purified by Ni-NTA chromatography . (bvsalud.org)
  • Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
  • Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
  • COUP-TFII regulates mouse Amhr2 gene transcription in MA-10 Leydig cells. (nih.gov)
  • Leukemia inhibitory factor (LIF), a pleiotropic cytokine from interleukin- (IL-) 6 family, regulates various cellular functions via binding to membrane-bound LIF receptor (LIFR) and gp130 [ 1 ]. (hindawi.com)
  • Here we review recent advances in understanding how glucose regulates gene transcription in mammals. (physiology.org)
  • ERK5 regulates muscle cell fusion through Klf transcription factors. (semanticscholar.org)
  • Epithelial progesterone-induced Indian hedgehog regulates stromal COUP-TFII, which in turn controls BMP2 to allow decidualization to manifest in vivo. (elsevier.com)
  • Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. (medecinesciences.org)
  • COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. (medecinesciences.org)
  • A 2009 study, published under the mentorship of Griffin P. Rodgers, discovered that in human erythrocytes (peripheral blood CD34+ cells), the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can be a crucial molecular mechanism that has the potential for the development of effective pharmacologic strategies for treatment of patients with sickle cell disease or other β-hemoglobinopathies. (wikipedia.org)
  • Binding of LIF to LIFR recruits gp130 to form high affinity functional receptor complex leading to activation of downstream signal transduction pathway such as signal transducer and activator of transcription (STAT) [ 3 ]. (hindawi.com)
  • In the differentiation of neurons and glia in the developing Drosophila eye, we found that the proper intensity of RTK signaling downstream of fibroblast growth factor receptor (FGFR) or epidermal growth factor receptor required two mutually antagonistic feedback loops. (sciencemag.org)
  • Using this animal model, we have identified a novel genetic pathway in which BMP2 lies downstream of COUP-TFII. (elsevier.com)
  • In addition, a variety of transcription factor families acting downstream of-or in concert with-these signaling networks play vital roles in arteriovenous (AV) specification. (edu.au)
  • After the model of eutopic primary cultured endometrial cells of endometiosis and hysteromyoma in vitro was successfully established, the changes of steroidgenic factor-1 (SF-1), chicken ovalbumin upstream-transcription factor (COUP-TF), 17-beta-hydroxysteroid dehydrogenase 1 (17-beta-HSD1) and 17-beta-hydroxysteroid dehydrogenase 2 (17-beta-HSD2) mRNA were detected by RT-PCR before and after treatment of medicated serum of SLW. (readbyqxmd.com)
  • In the present work, we report that COUP-TFII is an essential regulator of the gene encoding the anti-Müllerian hormone receptor type 2 ( Amhr2 ), which participates in Leydig cell differentiation and steroidogenesis. (nih.gov)
  • The receptor-ligand interaction induces two additional proteolytic cleavages in the membrane-tethered fragment of the Notch heterodimer. (biologists.org)
  • Cloning of expressed sequences in this region led to the identification of a two-exon gene encoding a novel member of the nuclear receptor family [ 4 ]. (hindawi.com)
  • This ligand-dependent regulation has become the focus of intense research, and over the past two decades, there have been tremendous efforts to identify nuclear receptor ligands and develop them for pharmaceutical purposes. (sciencemag.org)
  • Genomic footprinting analysis shows that the glucocorticoid receptor uses local DNA demethylation as one of several steps to recruit transcription factors in hepatoma cells. (embopress.org)
  • The nuclear receptor superfamily are ligand-activated transcription factors that play diverse roles in cell di erentiation/development, proliferation, and metabolism and are associated with numerous pathologies such as cancer, cardiovascular disease, infl ammation, and reproductive abnormalities. (cellsignal.com)
  • In addition to ligand binding, nuclear receptor activity can be modulated through the action of numerous growth factor and cytokine signaling cascades that result in receptor phosphorylation or other post-translational modifi cations, typically within the N-terminal transactivation domain. (cellsignal.com)
  • Prior to ligand binding, receptor heterodimers are located in the nucleus as part of complexes with histone deacetylases (HDACs) and other co-repressors that keep target DNA in a tightly wound conforma- tion, preventing exposure to transacting factors. (cellsignal.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 6 Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) ELISA Kits von 4 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Insgesamt sind aktuell 116 Nuclear Receptor Subfamily 2, Group F, Member 6 Produkte verfügbar. (antikoerper-online.de)
  • The orphan nuclear receptor Ear-2 (Nr2f6 ) is a novel negative regulator of T cell development. (antikoerper-online.de)
  • Depletion of TCF7L1 inhibits differentiation, because TCF7L1 indirectly induces the adipogenic transcription factor peroxisome proliferator-activated receptor γ in a manner that can be replaced by inhibition of myosin II activity. (pnas.org)
  • Growth hormone (GH) is a key hormone in the regulation of lactation in dairy cows (Bauman, 1992), its actions are mediated by the GH receptor (GHR) which following binding of the ligand dimerizes and activates the Janus kinase 2 second messenger pathway (Carter-Su et al. (espritrock.org)
  • 2001). GH receptor mRNA is expressed in two forms 1A and 1B (Adams, 1995) with the adult bovine liver expressing both forms while all other adult tissues only express 1B mRNA, the greatest amount of 1B is found in the liver with 1A being liver specific (Lucy et al. (espritrock.org)
  • C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12). (dovepress.com)
  • Nuclear Receptor Subfamily 4, Group A, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 2" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 2" by people in Profiles. (harvard.edu)
  • Meir T, Durlacher K, Pan Z, Amir G, Richards WG, Silver J, Naveh-Many T. Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. (harvard.edu)
  • COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. (wikipedia.org)
  • Preferentially binds to alpha-2,3-linked sialic acid. (genecards.org)
  • Highly conserved domain containing two zinc fingers that binds to specific sequences of DNA called hormone response elements (HRE). (gutenberg.org)
  • Steroid production is also reduced in COUP-TFII-depleted Leydig cells, supporting an additional role in steroidogenesis for this transcription factor. (nih.gov)
  • Regulation of the apolipoprotein A-I gene transcription. (uniprot.org)
  • Transcriptional regulation of the Coup-TFII gene in response to starvation and cold exposure seems to be the regulatory mechanism of Ucp3 mRNA expression in brown adipose and skeletal muscle tissue determining the final appropriate rate of transcript synthesis. (nih.gov)
  • Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. (jci.org)
  • The orchestration of these processes for different cell types requires the tight regulation of both intrinsic and extrinsic factors. (frontiersin.org)
  • Thus, during brain formation, the regulation of cell number and the precise timing of differentiation require the interplay between intrinsic programs of development and extrinsic factors. (frontiersin.org)
  • see below), an important transcription factor in the regulation of the fatty acid synthase ( FAS ) gene, is independent of external glucose. (physiology.org)
  • Tsai, Sophia Y. / COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity . (elsevier.com)
  • Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. (medecinesciences.org)
  • Several transcription factors have been shown to regulate the development of patch and/or matrix neurons by acting on the progenitors of MSN. (jneurosci.org)
  • In contrast, less is known about the transcription factor codes that regulate MSN differentiation and patch-matrix development after the progenitor stage. (jneurosci.org)
  • Here, through conditional mutagenesis, forced expression and transplantation we demonstrate that Coup-TF2 , in conjunction with Coup-TF1 , regulate cell cycle dynamics and cell fate decisions, including apoptosis, in MGE progenitors, but not in neurons. (biologists.org)
  • Nur77 and NURR1 can also heterodimerize with RXRs and these heterodimers are able to respond to RXR ligands to regulate transcription. (cellsignal.com)
  • 1996), whereas organizer signals, chordin and noggin, and X-lim1 negatively regulate BMP4 transcription (Kim et al. (atlasgeneticsoncology.org)
  • 1997). In mouse development, GATA-4 and - GATA-6 were found to specifically regulate BMP4 transcription to mediate endoderm-mesoderm signalling and early vasculogenesis (Nemer et al. (atlasgeneticsoncology.org)
  • 2008). Furthermore, the transcription factor Cdx2 has been shown to directly regulate BMP4 expression in mouse trophoblast cells to promote early mouse embryogenesis (Murohashi et al. (atlasgeneticsoncology.org)
  • 2011). In hepatocellular carcinoma cells, Ets-1 was demonstrated to directly regulate hypoxia-induced BMP4 transcription to promote tumorigenesis (Maegdefrau et al. (atlasgeneticsoncology.org)
  • Notch, COUP-TFII, and Prox1), While some factors specifically regulate lymphatic (Prox1), vein (COUP-TFII), or artery formation (Hey1/2), other vascular signaling pathways show overlapping activities (e.g. (biomedcentral.com)
  • The aim of this study was to identify trans -acting factors that bind to rs143383 and which regulate this GDF5 DAE. (prolekare.cz)
  • Using deletions and mutated constructs, we identified a Coup-TFII enhancer element 816-840 bp upstream of the transcriptional start site. (nih.gov)
  • Binding of Coup-TFII to this upstream enhancer was confirmed in electrophoretic mobility shift and supershift assays. (nih.gov)
  • Furthermore, we provide evidence that Coup-TF2 directs the development of layer V SST + interneurons, in part through driving Sox6 expression via an enhancer element near the Sox6 locus. (biologists.org)
  • In addition, the repressor COUP-TF becomes strongly bound to a different recognition site on the class I enhancer, where it associates with a histone deacetylase (HDAC) and E1A-12, resulting in chromatin compaction. (upenn.edu)
  • Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene. (ubc.ca)
  • This antibody does not cross-react with human COUP-TF I or EAR2. (novusbio.com)
  • Ear2 ligand binding domain is required for Rasd1 (zeige RASD1 ELISA Kits ) to alleviate Ear2 -mediated repression of renin (zeige REN ELISA Kits ) transcription. (antikoerper-online.de)
  • Antibody specifically recognices human COUP-TF I and cross reacts with mouse and rat COUP-TF I. This antibody does not recognices human COUP-TF II and EAR2. (peptanova.de)
  • The expression of the Prospero homeodomain transcription factor (Prox1) in a subset of cardinal venous cells specifies the lymphatic lineage in mice. (plos.org)
  • In zebrafish, there are two prox1 paralogues, the previously described prox1 (also known as prox1a ) and the newly identified prox1b . (plos.org)
  • After arterial and venous endothelial cells differentiate, a subpopulation of venous endothelial cells is thought to become competent to acquire lymphatic endothelial cell fate by progressively expressing the transcription factors Sox18 and Prox1 to differentiate into lymphatic endothelial cells. (edu.au)
  • We find that the transcription factor Ctip2 (also known as Bcl11b ) is central to MSN differentiation and striatal development. (jneurosci.org)
  • Th2 cells are important for responses to helminthic and other gastrointestinal parasitic infections, producing IL-4, IL-5, and IL-10, and stimulating B cell differentiation ( 2 ). (frontiersin.org)
  • This subset secretes key anti-inflammatory cytokines, notably TGFβ and IL-10, and Treg differentiation is driven by the transcription factor Foxp3. (frontiersin.org)
  • rs143383 is a C to T transition SNP located in the 5′untranslated region (5′UTR) of the growth differentiation factor 5 gene GDF5 . (prolekare.cz)
  • In vitro models of adipogenesis, such as the extensively studied committed preadipocyte cell line 3T3-L1 cells, have elucidated two major phases of adipogenesis: commitment and terminal differentiation ( 6 , 7 ). (pnas.org)
  • Moreover, recent studies demonstrated mutual inhibition between PXR and nuclear factor (NF)-κB signaling pathway, providing a potential molecular mechanism that links xenobiotic metabolism and inflammation [ 10 , 11 ]. (mdpi.com)
  • Our research utilises transgenic mouse models and focuses on understanding the molecular role of NRs (coregulators) and how they control metabolism in muscle, fat and the liver in the context of obesity and type 2 diabetes. (edu.au)
  • Together, our findings reveal a regulatory role of COUP-TFII in the development of muscular dystrophy and open up a potential therapeutic opportunity for managing disease progression in patients with DMD. (jci.org)
  • Ser118 may be the substrate of the transcription regulatory kinase CDK7, whereas Ser167 may be phosphorylated by p90RSK and Akt. (cellsignal.com)
  • Regulatory T (T reg ) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. (sciencemag.org)
  • Little is known regarding how the regulatory factors balance expression of this gene in ovarian cycles or spermatogenic stages. (bioone.org)
  • Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. (medecinesciences.org)
  • The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro culture condition from human or mouse adult erythroid cells, confirming previous microarray, as well as RNA-seq studies. (wikipedia.org)
  • Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways. (nih.gov)
  • By quantitative PCR we demonstrated a positive correlation of Coup-TFII and Ucp3 mRNA expression in skeletal muscle and brown adipose tissue in response to food deprivation and cold exposure, respectively. (nih.gov)
  • A) Depletion of COUP-TFII in MA-10 Leydig cells reduces Amhr2 gene expression. (nih.gov)
  • Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. (jci.org)
  • Coup-TF1 and Coup-TF2 autonomously repress PV + fate in MGE progenitors, in part through directly driving Sox6 expression. (biologists.org)
  • We showed that COUP-TFI is expressed in the stroma and mesenchymal cells at embryonic d 11.5 (E11.5) and expression persists throughout embryonic development. (nih.gov)
  • In the adult kidney, only mesangial cells show meaningful COUP-TFI expression. (nih.gov)
  • In contrast, COUP-TFII expression is detected as early as E9.5 and high expression is seen in the mesenchymal-derived epithelial cells but not in the ureteric buds through E12.5. (nih.gov)
  • At E13.5, COUP-TFII expression becomes regionalized with higher expression in the region that gives rise to the distal tubule. (nih.gov)
  • The proximal part of the S-shaped body that will become the glomerulus after endothelial cell migration shows COUP-TFII expression in podocyte precursor cells and epithelial cells of the Bowman's capsule. (nih.gov)
  • Here, we identify that retinoic acid (RA) signaling directly promotes the expression of the transcription factor Nr2f1a within the anterior lateral plate mesoderm. (zfin.org)
  • 2010). In retinal pigment epithelium cells of patients suffering from the wet form, but not the dry form, of macular degeneration, TNFalpha represses BMP4 transcription through phosphorylation of the transcription factor Sp1, demonstrating a BMP4 expression-dependent molecular switch (Xu et al. (atlasgeneticsoncology.org)
  • Exposure of fetuses to dibutyl phthalate (DBP), which induces masculinization disorders, dose-dependently prevented the age-related decrease in LC COUP-TFII expression and the normal increases in LC size and ITT. (qub.ac.uk)
  • We also show that once COUP-TFII expression in LC has switched off, it is re-induced by DBP exposure, coincident with suppression of ITT. (qub.ac.uk)
  • Furthermore, other treatments that reduce fetal ITT in rats (dexamethasone, diethylstilbestrol (DES)) also maintain/induce LC nuclear expression of COUP-TFII. (qub.ac.uk)
  • In contrast to rats, in mice DBP neither causes persistence of fetal LC COUP-TFII nor reduces ITT, whereas DES-exposure of mice maintains COUP-TFII expression in fetal LC and decreases ITT, as in rats. (qub.ac.uk)
  • As we also show an age-related decline in expression of COUP-TFII in human fetal LC, this mechanism may also be functional in humans, and its susceptibility to disruption by environmental chemicals, stress and pregnancy hormones could explain the origin of some human male reproductive disorders. (qub.ac.uk)
  • Further, the expression of sprouty was repressed and that of rau was increased by the COUP transcription factor Seven-up in the presence of weak, but not constitutive, activation of FGFR. (sciencemag.org)
  • Knockdown and over expression of the factors demonstrated that Sp1, Sp3, and DEAF-1 are repressors of GDF5 expression. (prolekare.cz)
  • In conclusion, we have identified four trans -acting factors that are binding to GDF5 , three of which are modulating GDF5 expression via the OA susceptibility locus rs143383. (prolekare.cz)
  • [18] The transcriptional activation of AF-1 is normally very weak, but it does synergize with AF-2 in the E-domain (see below) to produce a more robust upregulation of gene expression. (gutenberg.org)
  • Specification of arterial, venous, and lymphatic endothelial cells during embryonic development [2] "The groundbreaking discovery about arterial and venous expression of ephrinB2 and EphB4, respectively, in early embryonic development has led to a new paradigm for vascular research, providing compelling evidence that arterial and venous endothelial cells are established by genetic mechanisms before circulation begins. (edu.au)
  • CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. (nih.gov)
  • 3 Consequently, researchers must attempt to tease out what must be a dynamic interplay among heterogeneous genetic backgrounds, diverse environmental factors, and differential etiologies in the pathogenesis of this disorder, all of which make attempts to understand the genetic basis of hypertension a challenge. (ahajournals.org)
  • Whereas some of the disagreement among reports must arise from the factors discussed above (ie, genetic, etiologic, and environmental heterogeneity), a substantial proportion may be because of poorly defined inclusion criteria or inadequate appreciation of the importance of statistical power and replication. (ahajournals.org)
  • HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). (omeka.net)
  • Specifically, two novel platforms are being developed that intentionally modulate the AhR: (1) combining AhR agonists and DC-specific antibodies in liposomal nanoparticles to generate targeted immunosuppression, and (2) targeting both DCs and CD4+ T cells with AhR antagonist-loaded nanoparticles to block pollutant-induced immunotoxicity. (umt.edu)
  • Our hypothesis was that we would identify differentially expressed transcription factors, coregulators and chromatin-modifying enzymes. (biomedcentral.com)
  • 1 h) chromatin remodeling and recruitment of a first transcription factor, HNF‐3. (embopress.org)
  • Upon demethylation, two additional transcription factors are recruited when chromatin is remodeled. (embopress.org)
  • 1 The CXC chemokine stromal-derived-factor-1 (SDF-1 or CXCL12) is expressed in a variety of cells, including stromal cells (fibroblasts and endothelial cells). (dovepress.com)
  • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. (medecinesciences.org)
  • However, unlike deletion of Foxp3, lack of such transcription factors has not led to systemic lymphoproliferative diseases, but rather to more specific pathologies. (rupress.org)
  • T reg cell transcriptional program is dependent on the transcription factor (TF) Foxp3, which is also essential for their development and suppression function ( 1 - 3 ). (sciencemag.org)
  • These include the Hedgehog, Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-β (TGF-β), Wnt and Notch signaling pathways. (edu.au)
  • CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. (medecinesciences.org)
  • These include Notch and Notch-regulated transcription factors (e.g. (edu.au)
  • Understanding how islet cells sense changes in the concentration of blood glucose is an important question for human health since defective glucose-stimulated insulin release is a contributory factor in non-insulin-dependent diabetes mellitus (NIDDM). (physiology.org)
  • 1992) and insulin like growth factor-1 (IGF-1) synthesis and secretion with gene transcription positively regulated by GH (Hannon et al. (espritrock.org)
  • The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. (ubc.ca)
  • Coup-TFII mRNA is expressed in all examined tissue types as measured by qPCR. (nih.gov)
  • We have discovered PF-8, the processivity factor KSHV that enables the viral DNA polymerase (Pol-8) to remain on the template and incorporate thousands of nucleotides. (upenn.edu)
  • These findings suggest that lifting of repression by COUP-TFII may be an important mechanism that promotes increased testosterone production by fetal LC to drive masculinization. (qub.ac.uk)
  • Transcription factor predominantly involved in transcriptional repression. (antikoerper-online.de)
  • Glia maturation factor-γ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages. (nih.gov)
  • In rats, fetal LC size and intratesticular testosterone (ITT) increased ~3-fold between e15.5-e21.5 which associated with a progressive decrease in the percentage of LC expressing COUP-TFII. (qub.ac.uk)
  • Variable regions' in zinc finger 2 (zf2-VR), containing all non-conserved sites in zinc finger 2 within vertebrates, are shown for SP1, SP3, and SP4. (blogspot.com)
  • B) Zinc finger 2 (zf2) of human SP1, SP3, and SP4. (blogspot.com)
  • Each zinc finger contains an alpha-helix and two beta sheets (Philipsen et al. (blogspot.com)
  • MUC13 also contains 3 epidermal growth factor (EGF)-like domains and a cytoplasmic domain containing potential phosphorylation sites, which could play a role in cell signaling. (aacrjournals.org)
  • We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH (zeige CHDH Antikörper ) patients, particularly those with comorbid congenital heart defects. (antikoerper-online.de)