AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
COUP Transcription Factor ICOUP Transcription FactorsCOUP Transcription Factor IITranscription FactorsTranscription, GeneticScleroderma, LocalizedPromoter Regions, GeneticInsulin-Like Growth Factor IDNA-Binding ProteinsForeheadMolecular Sequence DataBase SequenceFacial HemiatrophySp1 Transcription FactorGene Expression RegulationComplement Factor I
COUP Transcription Factor I
A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.
COUP Transcription Factors
A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
COUP Transcription Factor II
A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Scleroderma, Localized
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Insulin-Like Growth Factor I
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Forehead
The part of the face above the eyes.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Facial Hemiatrophy
A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.
Sp1 Transcription Factor
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Complement Factor I
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site. (1/143)

The formation of various tissues requires close communication between two groups of cells, epithelial and mesenchymal cells. COUP-TFs are transcription factors which have been shown to have functions in embryonic development. COUP-TFI is expressed mainly in the nervous system, and its targeted deletion leads to defects in the central and peripheral nervous systems. COUP-TFII is highly expressed in the mesenchymal component of the developing organs. A null mutation of COUP-TFII results in the malformation of the heart and blood vessels. From their expression pattern, we proposed that COUP-TFs regulate paracrine signals important for mesenchymal cell-epithelial cell interactions. In order to identify genes regulated by COUP-TF in this process, a rat urogenital mesenchymal cell line was stably transfected with a COUP-TFI expression vector. We found that NGFI-A, a gene with important functions in brain, organ, and vasculature development, has elevated mRNA and protein levels upon overexpression of COUP-TFI in these cells. A study of the promoter region of this gene identified a COUP-TF-responsive element between positions -64 and -46. Surprisingly, this region includes binding sites for members of the Sp1 family of transcription factors but no COUP-TF binding site. Mutations that abolish the Sp1 binding activity also impair the transactivation of the NGFI-A promoter by COUP-TF. Two regions of the COUP-TF molecule are shown to be important for NGFI-A activation: the DNA binding domain and the extreme C terminus of the putative ligand binding domain. The C-terminal region is likely to be important for interaction with coactivators. In fact, the coactivators p300 and steroid receptor activator 1 can enhance the transactivation of the NGFI-A promoter induced by COUP-TFI. Finally, we demonstrated that COUP-TF can directly interact with Sp1. Taken together, these results suggest that NGFI-A is a target gene for COUP-TFs and that the Sp1 family of transcription factors mediates its regulation by COUP-TFs.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/143)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene. (3/143)

Nuclear orphan receptors are known to be important mediators of neurogenesis, but the target genes of these transcription factors in the vertebrate nervous system remain largely undefined. We have previously shown that a 500-base pair fragment in the first intron of the GRIK5 gene, which encodes the kainate-preferring glutamate receptor subunit KA2, down-regulates gene expression. In our present studies, mutation of an 11-base pair element within this fragment resulted in a loss of nuclear protein binding and reverses negative regulation by the intron. Using yeast one-hybrid screening, we have identified intron-binding proteins from rat brain as COUP-TFI, EAR2, and NURR1. Gel shift studies with postnatal day 2 rat brain extract indicate the presence of COUP-TFs, EAR2, and NURR1 in the DNA-protein complex. Competition assays with GRIK5-binding site mutations show that the recombinant clones exhibit differential binding characteristics and suggest that the DNA-protein complex from postnatal day 2 rat brain may consist primarily of EAR2. The DNA binding activity was also observed to be enriched in rat neural tissue and developmentally regulated. Co-transfection assays showed that recombinant nuclear orphan receptors function as transcriptional repressors in both CV1 cells and rat CG4 oligodendrocyte cells. Direct interaction of the orphan receptors with and relief of repression by TFIIB indicate likely role(s) in active and/or transrepression. Our findings are thus consistent with the notion that multiple nuclear orphan receptors can regulate the transcription of a widely expressed neurotransmitter receptor gene by binding a common element in an intron and directly modulating the activity of the transcription machinery.  (+info)

Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. (4/143)

We previously identified various upstream and downstream regulatory elements and factors important for hepatic expression of the human angiotensinogen (ANG) gene, the precursor of vasoactive octapeptide angiotensin II. In the present study, to further investigate the molecular mechanism of human ANG transcriptional regulation, we generated transgenic mice carrying the fusion gene composed of the 1. 3-kilobase promoter of the human ANG gene, its downstream enhancer, and the chloramphenicol acetyltransferase reporter gene. Because expression of the chloramphenicol acetyltransferase gene was observed strongly in the liver and weakly in the kidney, we suspected that hepatocyte nuclear factor (HNF) 4 with a tissue expression pattern similar to that of the reporter gene would regulate ANG transcription. In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. Furthermore, COUP-TF dramatically decreased the human ANG transcription in the mouse liver by the Helios Gene Gun system in vivo. These results suggest that an interplay between HNF4 and COUP-TF could be important in hepatic human ANG transcription.  (+info)

Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (5/143)

The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.  (+info)

The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. (6/143)

Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differentiation and premature cell death during corticogenesis. Our results indicate that the subplate neuron defects lead to the failure of guidance and innervation of thalamocortical projections. Thus, our findings demonstrate a critical role of the subplate in early corticothalamic connectivity and confirm the importance of afferent innervation for the survival of layer IV neurons. These results also substantiate COUP-TFI as an important regulator of neuronal development and differentiation.  (+info)

Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. (7/143)

Retinoic acid receptor beta (RARbeta) plays a critical role in mediating the anticancer effects of retinoids. Expression of RARbeta is highly induced by retinoic acid (RA) through a RA response element (betaRARE) that is activated by heterodimers of RARs and retinoid X receptors (RXRs). However, RARbeta induction is often lost in cancer cells despite expression of RARs and RXRs. In this study, we provide evidence that orphan receptor COUP-TF is required for induction of RARbeta expression, growth inhibition, and apoptosis by RA in cancer cells. Expression of COUP-TF correlates with RARbeta induction in a variety of cancer cell lines. In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARbeta expression, growth inhibition, and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects. In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARbeta promoter in a RA- and RARalpha-dependent manner. By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARbeta promoter. The binding of COUP-TF to the DR-8 element synergistically increases the RA-dependent RARalpha transactivation function by enhancing the interaction of RARalpha with its coactivator CREB binding protein. These results demonstrate that COUP-TF, by serving as an accessory protein for RARalpha to induce RARbeta expression, plays a critical role in regulating the anticancer activities of retinoids.  (+info)

The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. (8/143)

Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system and plays a direct role in the pathogenesis of AIDS dementia. However, the molecular mechanisms underlying HIV-1 expression in the central nervous system are poorly understood. We have recently reported that the nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF), an orphan member of the nuclear receptor superfamily, is an activator of HIV-1 gene transcription. Here, our results show that COUP-TF stimulates HIV-1 transcription in primary cultured human microglial cells, the primary target for HIV-1 infection in brain. Run-on assays indicated that COUP-TF acts on the initiation step of transcription. Results from reverse transcription-polymerase chain reaction and immunocytochemistry analysis further revealed the importance of this factor by demonstrating that overexpression of COUP-TF leads to initiation of viral replication in primary HIV-infected human microglia. In addition, COUP-TF is able to physically interact and cooperate with the viral transactivator Tat. The combination of COUP-TF and Tat leads to NF-kappaB- and Sp1-independent enhanced transcriptional stimulation. In vitro binding studies showed that COUP-TF interacts with Tat through amino acids within the N-terminal DNA-binding domain of COUP-TF. Amino acids 48-72 in the basic and C-terminal regions of Tat are required for the binding of Tat to COUP-TF. These results suggest that COUP-TF is an essential transcription factor involved in HIV-1 expression in microglia and reveal a novel interplay of Tat and COUP-TF during regulation of viral expression.  (+info)

The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
http://biodiversityhotspot.org/2019/06/the-chicken-ovalbumin-upstream-promoter-transcription-factors-coup-tfs-are-members-from/
Plus itPlus it
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
http://mct.aacrjournals.org/content/6/11_Supplement/B168
Orphan Receptor Chicken Ovalbumin Upstream Promoter Transcription Factors Inhibit Steroid Factor-1, Upstream Stimulatory Factor...Orphan Receptor Chicken Ovalbumin Upstream Promoter Transcription Factors Inhibit Steroid Factor-1, Upstream Stimulatory Factor...
Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
https://bioone.org/journals/biology-of-reproduction/volume-66/issue-6/biolreprod66.6.1656/Orphan-Receptor-Chicken-Ovalbumin-Upstream-Promoter-Transcription-Factors-Inhibit-Steroid/10.1095/biolreprod66.6.1656.short
COUP-TFI - wikidoc
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
http://es.wikidoc.org/index.php/COUP-TFI
Search Results for HSP60 | jmeSearch Results for HSP60 | jme
In the mosquito Aedes aegypti, vitellogenesis is activated via an ecdysteroid hormonal cascade initiated by a blood meal. The functional ecdysone receptor is a heterodimer composed of the ecdysone receptor (EcR) and ultraspiracle, the homolog of the retinoid X receptor. The precise tuning of this hormonal response requires participation of both positive and negative transcriptional regulators. In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor complex-mediated transactivation in vitro and in vivo. Here we report the cloning and characterization of the Svp homolog in mosquito Aedes aegypti, AaSvp. It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. AaSvp transcripts and protein are present in the fat body at high levels from the state of arrest to about 60 h post blood meal. AaSvp binds strongly to a variety of direct repeats of the sequence AGGTCA, but weakly to ...
https://jme.bioscientifica.com/search?q=HSP60
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4 + T cell effector functions | Cell Communication and...Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4 + T cell effector functions | Cell Communication and...
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. NR2F6 serves as an antigen receptor signaling threshold-regulated barrier against autoimmunity where NR2F6 is part of a negative feedback loop that limits inflammatory tissue damage induced by weakly immunogenic antigens such as self-antigens. Under such low affinity antigen receptor stimulation, NR2F6 appears as a prototypical repressor that functions to
https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-12-38/metrics
Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal AxisGradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis
AbstractThe hippocampus (HP), a medial cortical structure, is subdivided into a distinct dorsal (septal) and ventral (temporal) portion, which is separated by an intermediate region lying on a longitudinal curvature. While the dorsal portion is more dedicated to spatial navigation and memory, the mo
https://insights.ovid.com/cerebral-cortex/cecor/2017/02/000/gradient-coup-tfi-expression-required-functional/58/00008354
COUP-TF I/NR2F1 Antibody (NBP2-15974): Novus BiologicalsCOUP-TF I/NR2F1 Antibody (NBP2-15974): Novus Biologicals
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
https://www.novusbio.com/products/coup-tf-i-nr2f1-antibody_nbp2-15974
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter...Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter...
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
https://agsci.oregonstate.edu/biblio/regulation-retinoic-acid-induced-inhibition-ap-1-activity-orphan-receptor-chicken-ovalbumin
COUP-TF I | definition of COUP-TF I by Medical dictionaryCOUP-TF I | definition of COUP-TF I by Medical dictionary
Looking for online definition of COUP-TF I in the Medical Dictionary? COUP-TF I explanation free. What is COUP-TF I? Meaning of COUP-TF I medical term. What does COUP-TF I mean?
http://medical-dictionary.thefreedictionary.com/COUP-TF+I
Anti-Human YB-1 Antibody | Human YB-1 Antibody | YB-1 AntibodyAnti-Human YB-1 Antibody | Human YB-1 Antibody | YB-1 Antibody
Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cancer_and_Inflammation/YB-1?sitex=10020:22372:US&PEBCL1=Dm7FTxG1FysZdkrBbUhf5DYMmG&PEBCL1_pses=ZGC4A6FA625F7A680505A469470BE11678F412EBC881A2F2AF1B86A6E123958A18D38BCB6D5BF3FB3075DA61477DCD2CD4A82AFC1EAC80FE84
Assoc. Prof. Dr. Umut ŞAHIN | MBGAssoc. Prof. Dr. Umut ŞAHIN | MBG
Aside from harboring a vast amount of genetic material, the eukaryotic nucleus is highly organized into distinct microenvironments such as PML nuclear bodies. This organization is often compromised in cancer and viral diseases. For example, in acute promyelocytic leukemia (APL), an aggressive subtype of myeloid leukemias, PML nuclear bodies are disrupted. A combination of two potent drugs - arsenic & retinoic acid - can enforce reformation of PML nuclear bodies and cure APL. The scaffold of PML nuclear bodies is the PML (promyelocytic leukemia) protein. In APL a genetic defect creates a fusion oncogene: PML/RARA. The latter impairs the function of PML protein and disrupts PML nuclear bodies. PML nuclear bodies recruit numerous partner proteins, including transcription factors (i.e. P53, Rb) and DNA repair proteins. ...
http://mbg.boun.edu.tr/?q=en/node/62
COUP Transcription Factors Summary Report | CureHunterCOUP Transcription Factors Summary Report | CureHunter
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
http://www.curehunter.com/public/keywordSummaryD051836-COUP-Transcription-Factors.do
Gene Expression Literature DetailGene Expression Literature Detail
J:112461 Tang LS, Alger HM, Pereira FA, COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006 Sep;133(18):3683-93 ...
http://www.informatics.jax.org/gxdlit/key/60516
Sport coupé synonyms, Sport coupé antonyms - FreeThesaurus.comSport coupé synonyms, Sport coupé antonyms - FreeThesaurus.com
Synonyms for Sport coupé in Free Thesaurus. Antonyms for Sport coupé. 5 words related to coupe: auto, automobile, car, motorcar, machine. What are synonyms for Sport coupé?
http://www.freethesaurus.com/Sport+coup%C3%A9
ReMap2020ReMap2020
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] ...
http://remap.univ-amu.fr/target_page/NR2F2:9606
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Search used Mercedes-Benz GLE Coupé for sale in the UK at Evans Halshaw, or learn more about purchasing a pre-owned example.
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Evan Rosen, M.D., Ph.D. | Boston Area Diabetes Endocrinology Research CentersEvan Rosen, M.D., Ph.D. | Boston Area Diabetes Endocrinology Research Centers
1. Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metabolism. 2008; 7:86-94. PMCID:PMC2278019. 2. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA. 2008; 105: 2421-2426. PMCID:PMC2268152. 3. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, and Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010. 143; 156-169. PMCID:PMC2950833. 4. Eguchi J, Wang X, Yu S, Kershaw EE, Chui PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, and Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metabolism. 2011; 13: 249-259. PMCID: PMC3063358. 5. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong S-E, and Rosen ED. FOSL2 promotes adipocyte-specific leptin gene ...
https://www.baderc.org/evan-rosen-m-d-ph-d/
JCI - COUP-TFII regulates satellite cell function and muscular dystrophyJCI - COUP-TFII regulates satellite cell function and muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
https://www.jci.org/articles/view/87414/pdf
JCI - WelcomeJCI - Welcome
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
https://sdjiaheng.net.insight.mobile.jci.org/articles/view/87414/cite
Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons | DevelopmentCoup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons | Development
Regional and cell-type specification during embryogenesis are often coupled to expression of TFs that are restricted to specific progenitor domains. Here, we found that Nkx2-1 restricts the expression of Coup-TF1/2 in the MGE to an arc that extended from a small rostrodorsal domain to a larger caudoventral domain (Fig. 1; Fig. S1B,D,H,K,L). The Coup-TF1/2+ MGE domain was complementary to an Otx2+ domain (Fig. S1B-E), where Otx2 represses Coup-TF1 MGE expression (Hoch et al., 2015a,b).. Our data support a model in which the Coup-TF1/2+ MGE domain is biased towards generating SST+ CINs (Fig. 2; Fig. S3A-C), as well as cholinergic and pallidal neurons (Fig. S4). These conclusions differ from other publications regarding the major location for the origin of SST+ interneurons, and provide evidence for a Coup-TF1/2-dependent activation of Sox6 expression that promotes SST+ interneuron development.. Multiple lines of evidence show that Coup-TF1/2 have key roles in promoting SST+ interneuron ...
http://dev.biologists.org/content/144/15/2837
Search results for: NR2F2Search results for: NR2F2
Alias: NR2F2, ARP1, ARP-1, COUP transcription factor II, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, COUPTFII, COUP transcription factor 2, EAR3, NF-E3, SVP40, COUPTF-II, TFCOUP2 ...
https://www.avivasysbio.com/catalogsearch/result/?order=cb_product_weighting&dir=desc&q=NR2F2
Egyptian coup detat - Latest News on Egyptian coup detat | Read Breaking News on Zee NewsEgyptian coup detat - Latest News on Egyptian coup detat | Read Breaking News on Zee News
Egyptian coup detat - Get latest news on Egyptian coup detat. Read Breaking News on Egyptian coup detat updated and published at Zee News
http://zeenews.india.com/tags/egyptian-coup-d%E2%80%99etat.html
COUP September 3rd Options Begin Trading | NasdaqCOUP September 3rd Options Begin Trading | Nasdaq
Investors in Coupa Software Inc (Symbol: COUP) saw new options begin trading today, for the September 3rd expiration. At Stock Options Channel, our YieldBoost formula has looked up and down the COUP options chain for the new September 3rd contracts and identified one put and
https://www.nasdaq.com/articles/coup-september-3rd-options-begin-trading-2021-07-22
Active Motif » NR2F2 / COUP2 antibody (pAb)Active Motif » NR2F2 / COUP2 antibody (pAb)
This NR2F2 / COUP2 polyclonal antibody from Active Motif has been validated for use in Chromatin Immunoprecipitation (ChIP) and Western blot.
http://www.activemotif.com/catalog/details/61213/nr2f2-coup2-antibody-pab
Army Officer Warns Of DHS Coup: Emergency ReportArmy Officer Warns Of DHS Coup: Emergency Report
In this video, Alex explains why there has been a coup détat against our Constitutional Republic, and breaks down why the office of the presidency is becoming dictatorial.. Read: Retired Army Captain Warns DHS Acquisitions are bold threat of war Against the American People - http://www.infowars.com/retired-army-captain-warns-recent-dhs-acquisitions-are-bold-threat-of-war… ...
https://www.infowars.com/army-officer-warns-of-dhs-coup-emergency-report/
Peugeot 407 Coup : prvn foto a informace | auto.czPeugeot 407 Coup : prvn foto a informace | auto.cz
Ze studie 407 Prologue se zrodil Peugeot 407 Coup . Sv tov premi ra je p ipravena na z iov Frankfurt. Z kladn cena by m la atakovat milionovou hranici.
http://www.auto.cz/peugeot-407-coupe-prvni-foto-a-informace-15448
Why COUP? | COUP MovementWhy COUP? | COUP Movement
Presentations are the key to your success. They connect your ideas, your know-how, your stories, and your offerings with your target groups. But: it gets increasingly difficult to hold peoples attention. Youll lose if you dont master the art of presenting.
https://www.coupmovement.com/why
Besidin (Cimetidine) CoupBesidin (Cimetidine) Coup
Besidin information about active ingredients, pharmaceutical forms and doses by Coup, Besidin indications, usages and related health products lists
http://drugs-about.com/drugs-b/besidin.html
NLD Patron U Win Htein Arrested for Sedition After Condemning CoupNLD Patron U Win Htein Arrested for Sedition After Condemning Coup
The ailing confidant of Daw Aung San Suu Kyi and longtime former political prisoner called for nonviolent public opposition to the military regime shortly after Mondays coup.
https://www.irrawaddy.com/news/burma/nld-patron-u-win-htein-arrested-sedition-condemning-coup.html
The New BMW 1 Series M CoupéThe New BMW 1 Series M Coupé
/PRNewswire/ -- The new BMW 1 Series M Coupé heralds the introduction of a high performance sports car into a compact design that extends the BMW M portfolio...
https://www.prnewswire.co.uk/news-releases/the-new-bmw-1-series-m-coupe-145276295.html
Skoda Kodiaq Review (2021) | AutocarSkoda Kodiaq Review (2021) | Autocar
And yet this one damned near has. The Kodiaq is a compact SUV with a twist of extra space and functionality: a car, in prospect, thats as modern and close to as fuel efficient as any other 4x4 on the Volkswagen Groups MQB platform but approaches the size and usefulness of the Sorentos seven-seat sub-breed.. And we can take its blend of simple functionality, space and value for money as a preview of what to expect from the new Yeti, due in 2018, and the smaller crossover that will follow it by the end of the decade. Beyond, being the new corporate face of Skoda SUVs, the Kodiaq may also spark adventures into pastures new for the Czech manufacturer.. Following the standard SUV is the Kodiaq Scout, which brings genuine off-roading ability and underbody protection, while bosses are toying with the prospect of launching a vRS version as well as a coupé version of the Kodiaq in the same ilk as the BMW X6 and Mercedes-Benz GLE Coupé.. The Kodiaq also brings new driver assistance systems, new ...
https://www.autocar.co.uk/car-review/skoda/kodiaq
McDonnell: Soft Coup Underway, Murdoch and Moderates Behind Plot - Guido FawkesMcDonnell: Soft Coup Underway, Murdoch and Moderates Behind Plot - Guido Fawkes
John McDonnell has issued an extraordinary warning to the Corbynite left that a soft coup is in progress to unseat Jeremy Corbyn. McDonnell accuses an
https://order-order.com/2017/02/27/mcdonnell-soft-coup-underway-murdoch-moderates-behind-plot/
Xconomy: Counting Coups: Better, Fewer Deals in 2011 for Venture-Backed Cos.Xconomy: Counting Coups: Better, Fewer Deals in 2011 for Venture-Backed Cos.
2011 was a year of bigger deals and fewer exits for venture-backed companies, according to data being released today by Dow Jones VentureSource.
https://xconomy.com/national/2012/01/03/counting-coups-better-fewer-deals-in-2011-for-venture-backed-cos/
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice | ScienceElimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice | Science
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
https://science.sciencemag.org/content/357/6352/717.abstract
Coup detát | definition of Coup detát by Medical dictionaryCoup detát | definition of Coup detát by Medical dictionary
Looking for online definition of Coup d'etát in the Medical Dictionary? Coup d'etát explanation free. What is Coup d'etát? Meaning of Coup d'etát medical term. What does Coup d'etát mean?
http://medical-dictionary.thefreedictionary.com/Coup+d
1941 Iraqi coup détat | Military Wiki | Fandom1941 Iraqi coup détat | Military Wiki | Fandom
The 1941 Iraqi coup détat, also known as the Rashid Ali Al-Gaylani coup or the Golden Square coup, was a pro-Nazi military coup in Iraq on April 1, 1941 that overthrew the regime of Regent Abd al-Ilah and installed Rashid Ali as Prime Minister. It was led by four Iraqi nationalist army...
https://military.wikia.org/wiki/1941_Iraqi_coup_d%27%C3%A9tat
Failed Coup | Fact-Checking TurkeyFailed Coup | Fact-Checking Turkey
Fethullah Gulen penned an article for the New York Times on 25 July 2016, ten days after the failed coup attempt in Turkey. In the article, Gulen denies any involvement in the recent coup attempt and asks the US not to extradite him.. Read more ...
https://factcheckingturkey.com/failed-coup?page=3
Turkeys Curious Coup: What Turkeys Western Allies Make of the Evidence against Gülen - Hizmet StudiesTurkeys Curious Coup: What Turkeys Western Allies Make of the Evidence against Gülen - Hizmet Studies
A year after the Turkeys coup attempt, there are still many questions that need to be considered. Below you could find a summary of what makes the coup attempt so curious and the positions of the Turkish Government, Gulen Movement and Turkeys Western allies.
https://www.hizmetstudies.org/news/press-release/turkeys-curious-coup-turkeys-western-allies-make-evidence-gulen/
Expression of Nuclear Receptors during Adipogenesis of 3T3-L1 Cells COUP-TFI COUP-TFII PPAR  VDR GCNF ROR  HNF4  LXR  LXR ...Expression of Nuclear Receptors during Adipogenesis of 3T3-L1 Cells COUP-TFI COUP-TFII PPAR  VDR GCNF ROR  HNF4  LXR  LXR ...
LXR α 0h 4h 8h 18h 1D 2D 3D 4D 5D 6D 7D 8D h 2d d Induction MediumDifferentiation Medium NR Expression during Adipogenesis of 3T3-L1 Cells (2) Fu et al., Mol. Endo. 19: 2437 (2005) Nur77 PPAR γ NUR77 LXR  PPAR 
http://slideplayer.com/slide/3347478/
Failed coup in Turkey: What you need to know - CNNFailed coup in Turkey: What you need to know - CNN
The president blames a self-exiled cleric in the U.S. for the failed coup, Turkey rounds up collaborators and world and NATO relations could see changes.
https://edition.cnn.com/2016/07/18/middleeast/turkey-failed-coup-explainer/index.html
Volvo Concept XC Coupé wins Best Concept Car at Detroit auto showVolvo Concept XC Coupé wins Best Concept Car at Detroit auto show
The Volvo Concept XC Coupé that debuted at the Detroit auto show a couple weeks ago managed to snag not one but two design awards at the show. This is
https://www.autoweek.com/news/a1886001/volvo-concept-xc-coup-wins-best-concept-car-detroit-auto-show/
BMW 4 Series Gran Coupé: Connectivity & Driver AssistanceBMW 4 Series Gran Coupé: Connectivity & Driver Assistance
When driving the BMW 4 Series Gran Coupé, you receive support from a wide range of innovative technologies that significantly increase your comfort.
https://www.bmw.co.za/en/all-models/4-series/gran-coupe/2017/connectivity-driver-assistance.html
Coup DEclat Facial Lifting Vials | Skin Care | Feel22 | Worldwide Shipping - feel22.comCoup DEclat Facial Lifting Vials | Skin Care | Feel22 | Worldwide Shipping - feel22.com
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Coup DEclat Facial Lifting Vials | Skin Care | Feel22 | Worldwide Shipping - feel22.comCoup DEclat Facial Lifting Vials | Skin Care | Feel22 | Worldwide Shipping - feel22.com
Get Coup DEclat Facial Lifting Vials delivered to your home by ordering it online at Feel22 and check our wide range of Skin care. GET FAST INTERNATIONAL DELIVERY & 20% FIRST ORDER! Shop online now!
https://int.feel22.com/ar/collections/skin-care-1/products/coup-declat-facial-lifting-vials
Thailands oldest party will join coup leaders coalition - ABC NewsThailands oldest party will join coup leaders coalition - ABC News
Thailands prime minister appears set to win a parliamentary vote for a second term in office five years after he took power in a military coup
https://abcnews.go.com/International/wireStory/thailands-democrats-vote-join-coup-leaders-coalition-63544595
Nigeria: Coup Aftermath. - British PathéNigeria: Coup Aftermath. - British Pathé
The Nigerian military successfully staged their fifth coup in 17 years on December 31.They seized power from President Shehu Shagari, ending four years of democratic civilian rule.The army, led by Major-General Mohammed Buhari; 41, said in an early-morning…
https://britishpathe.com/video/VLVA4S6QKUVZ1D5J0UFIPYUAU1B4V-NIGERIA-COUP-AFTERMATH/query/Aftermath
The Brazilian Coups Image Problem | Boston ReviewThe Brazilian Coups Image Problem | Boston Review
The Brazilian Coups Image Problem from Boston Review. New leaks prove the impeachment is intended to protect corrupt politicians.
http://bostonreview.net/world/gianpaolo-baiocchi-brazilian-coup-image-problem
Tea Party Leader Reportedly Made Coup Attempt |...Tea Party Leader Reportedly Made Coup Attempt |...
Former House Majority Leader Dick Armey (R-Texas), who abruptly resigned as head of Tea Party group FreedomWorks, brought in an assistant with a gun in an apparent coup attempt at the group, according to a report in the Washington Post. | this curious life
https://www.scoop.it/t/this-curious-life/p/3861833461/2012/12/27/tea-party-leader-reportedly-made-coup-attempt
You Get One Life So Do It All - COUP ChampagneYou Get One Life So Do It All - COUP Champagne
You Get One Life So Do It All Laser-engraved black metal label. Hand painted matte black bottle. (Select from a variety of sabering, and gift case options)___________________________ La Cuvée Brut Champagne by Dumangin 91 Points Fresh, fruity and with a complex structure, this deep cellar aged cuvée blends equal propor
https://coupchampagne.com/collections/inspiration/products/you-get-one-life-so-do-it-all
The Quiet Coup - The AtlanticThe Quiet Coup - The Atlantic
The crash has laid bare many unpleasant truths about the United States. One of the most alarming, says a former chief economist of the International Monetary Fund, is that the finance industry has effectively captured our government—a state of affairs that more typically describes emerging markets, and is at the center of many emerging-market crises. If the IMF’s staff could speak freely about the U.S., it would tell us what it tells all countries in this situation: recovery will fail unless we break the financial oligarchy that is blocking essential reform. And if we are to prevent a true depression, we’re running out of time.
https://www.theatlantic.com/magazine/archive/2009/05/the-quiet-coup/307364/
Thailands Non-Coup CoupThailands Non-Coup Coup
After months of political crisis, the generals declare martial law. They claim theyre just making peace, not running the country.
https://www.thedailybeast.com/thailands-non-coup-coup?source=dictionary
Brazil bound: Socceroos set for world stage | Whitsunday TimesBrazil bound: Socceroos set for world stage | Whitsunday Times
In a major coup the Socceroos will have the opportunity to compete with the best in the world next year after a historic agreement.
https://www.whitsundaytimes.com.au/news/brazil-bound-socceroos-set-for-world-stage/3753097/
Bioinformatics Research and Applications | SpringerLinkBioinformatics Research and Applications | SpringerLink
1.School of Biology, Department of Biomedical Engineering and College of ComputingGeorgia Institute of TechnologyAtlanta, GeorgiaUSA ...
https://link.springer.com/book/10.1007/978-3-642-13078-6
COUP transcription factorCOUP transcription factor
... may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ... humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor ...
https://en.wikipedia.org/wiki/COUP_transcription_factor
COUP-TFICOUP-TFI
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...
https://en.wikipedia.org/wiki/COUP-TFI
COUP-TFIICOUP-TFII
... (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe- ... "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207-16. PMC 5952191. PMID ...
https://en.wikipedia.org/wiki/COUP-TFII
Griffin P. RodgersGriffin P. Rodgers
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...
https://en.wikipedia.org/wiki/Griffin_P._Rodgers
UteroglobinUteroglobin
"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ...
https://en.wikipedia.org/wiki/Uteroglobin
BCL11BBCL11B
"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... Transcription factors, All stub articles, Human chromosome 14 gene stubs). ... BCL11B has been shown to interact with COUP-TFI. BCL11B is closely connected with immune regulation and for so its mutation can ...
https://en.wikipedia.org/wiki/BCL11B
BCL11ABCL11A
... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... BCL11A was initially discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize ... Transcription factors, All stub articles, Human chromosome 2 gene stubs). ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ...
https://en.wikipedia.org/wiki/BCL11A
NucleolinNucleolin
... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ...
https://en.wikipedia.org/wiki/Nucleolin
Geoffrey M. CooperGeoffrey M. Cooper
Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746. Hartley, D. and Cooper, G.M. ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and ... Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ...
https://en.wikipedia.org/wiki/Geoffrey_M._Cooper
Ceramide kinaseCeramide kinase
... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ... RARE-like plays a role in transcription regulation of CERK. It is suspected that in the presence of all-trans retinoic acid ( ...
https://en.wikipedia.org/wiki/Ceramide_kinase
Chicken ovalbumin upstream promoter-transcription factorChicken ovalbumin upstream promoter-transcription factor
COUP+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) COUP+Transcription+Factor+I ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ... intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the ... Park JI, Tsai SY, Tsai MJ (2003). "Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) ...
https://en.wikipedia.org/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor
Estrogen receptor alphaEstrogen receptor alpha
Budhram-Mahadeo V, Parker M, Latchman DS (February 1998). "POU transcription factors Brn-3a and Brn-3b interact with the ... July 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ... heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress & Chaperones. 1 (4): 237-250. PMC 376461 ...
https://en.wikipedia.org/wiki/Estrogen_receptor_alpha
Aryl hydrocarbon receptorAryl hydrocarbon receptor
The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ... Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ...
https://en.wikipedia.org/wiki/Aryl_hydrocarbon_receptor
Retinoid X receptor alphaRetinoid X receptor alpha
The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ...
https://en.wikipedia.org/wiki/Retinoid_X_receptor_alpha
Fibroblast growth factor 8Fibroblast growth factor 8
Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is ... Tanaka S, Ueo H, Mafune K, Mori M, Wands JR, Sugimachi K (May 2001). "A novel isoform of human fibroblast growth factor 8 is ...
https://en.wikipedia.org/wiki/Fibroblast_growth_factor_8
Nuclear receptor 4A1Nuclear receptor 4A1
This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is ... Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses ...
https://en.wikipedia.org/wiki/Nuclear_receptor_4A1
V-erbA-related geneV-erbA-related gene
V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... Transcription factors, All stub articles, Human chromosome 19 gene stubs). ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...
https://en.wikipedia.org/wiki/V-erbA-related_gene
List of MeSH codes (D12.776.930)List of MeSH codes (D12.776.930)
... coup transcription factor i MeSH D12.776.930.682.074.500 - coup transcription factor ii MeSH D12.776.930.682.350.174 - estrogen ... transcription factor brn-3b MeSH D12.776.930.632.625.875 - transcription factor brn-3c MeSH D12.776.930.635.600.100 - ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 - mafk transcription factor MeSH D12.776.930.127.656.770 - nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 - mafk transcription factor MeSH D12.776.930.316.750.770 - nf-e2 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.930)
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ... fibroblast growth factor 4 MeSH D12.776.624.664.700.112 - fibroblast growth factor 6 MeSH D12.776.624.664.700.114 - fms-like ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
HDAC1HDAC1
"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase ...
https://en.wikipedia.org/wiki/HDAC1
Blackfoot languageBlackfoot language
"This is my coup story." A story in the Great Falls Tribune noted, "When the station was replaying programming that originated ... The transcription uses an official, technically accurate alphabet and the authors of this book have classified entries and ... According to the UNESCO Factor 9: Amount and Quality of Documentation, there may be adequate grammar or sufficient amount of ... According to the UNESCO Factor 1: Intergenerational Transmission, Blackfoot is classified under severely endangered. It is ...
https://en.wikipedia.org/wiki/Blackfoot_language
Nuclear receptorNuclear receptor
... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often ... referred to as transcription coregulators) that facilitate or inhibit the transcription of the associated target gene into mRNA ...
https://en.wikipedia.org/wiki/Nuclear_receptor
LckLck
... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 ( ... "Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine ...
https://en.wikipedia.org/wiki/Lck
Leadership analysisLeadership analysis
Applied analysts make great use of the psychobiography, while academics tend to analyze transcriptions in search of traits and ... Relate personality to key issues, emphasizing in which direction the psychological factors point. Estimate drives, values, and ... when most leaders of coups emerge), or in old age, when leaders, especially narcissists, feel the reins of power slipping and ... and cognitive factors. The important thing to note about leadership analysis is the consistency of the individual's belief ...
https://en.wikipedia.org/wiki/Leadership_analysis
HM Prison Wormwood ScrubsHM Prison Wormwood Scrubs
Julet Armstrong, protagonist of the 2018 Kate Atkinson World War II novel Transcription, works for MI5 for a time in the Scrubs ... A 2021 inquest subsequently identified the prison's failure to provide food and medication as contributing factors to the death ... Billy Liar The Man In Possession The Spy Who Came in from the Cold The Horse's Mouth Hot Millions Frenzy A Very British Coup ...
https://en.wikipedia.org/wiki/HM_Prison_Wormwood_Scrubs
Nazism and the WehrmachtNazism and the Wehrmacht
Not only letters and diaries of combat soldiers indicate that ideology was a considerable factor in German combat effectiveness ... significantly reducing the coup risk Hitler faced from building an effective army. However, as the successor to a ... Using transcriptions of secret records of conversations among POWs, they conclude that most soldiers were not interested in ... politics were not a factor. During World War II, the German military had thousands of its members executed, often for the most ...
https://en.wikipedia.org/wiki/Nazism_and_the_Wehrmacht
Hawaiian languageHawaiian language
These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... in making handwritten transcriptions of Hawaiian vowels. The missionaries specifically requested their sponsor in Boston to ... The decline of the Hawaiian language was accelerated by the coup that overthrew the Hawaiian monarchy and dethroned the ... implications for revitalization efforts as language attitudes and trends in existing language domains are both UNESCO factors ...
https://en.wikipedia.org/wiki/Hawaiian_language
John AdamsJohn Adams
In 1799, Napoleon took over as head of the French government in the Coup of 18 Brumaire and declared the French Revolution over ... Ferling attributes Adams's defeat to five factors: the stronger organization of the Republicans; Federalist disunity; the ... "Declaration of Independence: A Transcription". United States National Archives. November 2015. Retrieved October 1, 2018. " ...
https://en.wikipedia.org/wiki/John_Adams
Macedonian frontMacedonian front
Another major factor contributed to the Bulgarian request for an armistice. A mass of retreating Bulgarian mutineers had ... transcriptions of primary source documents, listing which units redeployed to Salonika Falls 1933, pp. 31-32, 42-50. Falls 1933 ... With Allied assistance, they launched a coup which secured Thessaloniki and most of Greek Macedonia for Venizelos. From that ... After the entry of the Ottoman Empire into the war on the side of the Central Powers (November 1914), the decisive factor in ...
https://en.wikipedia.org/wiki/Macedonian_front
Judaism and pop and rock musicJudaism and pop and rock music
"Interview: Michael Shuman on the 'Feed' soundtrack". Coup De Main. Azerrad, Michael. "THE REAL STORY ABOUT MARK SANDMAN". {{ ... Canarsie was misspelled as "Canarsey" in the transcription. Frydberg, Tracy (July 22, 2012). "Justin tweets tween Madison to ... "Who is Raign? 8 facts about the controversial X Factor 2014 contestant". Metro. 8 September 2014. Retrieved 28 September 2014 ...
https://en.wikipedia.org/wiki/Judaism_and_pop_and_rock_music
Black powerBlack power
Transcription by Andrew Pollack for the Encyclopaedia of Trotskyism On-Line. Brown, Scot, Fighting for US: Maulana Karenga, the ... It is often described as an attempted military coup. Williams, who was accused of upholding colonial and capitalist power ... dictating that black Americans create their own identities despite being subjected to pre-existing societal factors. "Black ...
https://en.wikipedia.org/wiki/Black_power
RCARCA
He was ousted in a 1975 "boardroom coup" led by Anthony Conrad, who became the new company president. Conrad resigned less than ... "RCA Program Transcription Album Discography (1931-33)". bsnpubs.com. Both Sides Now Publications. Retrieved August 19, 2015. A ... which would be an important factor in helping RCA survive the economic pressures of the Great Depression that began in late ...
https://en.wikipedia.org/wiki/RCA
Plymouth ColonyPlymouth Colony
Standish led two early military raids on Indian villages: the raid to find and punish Corbitant for his attempted coup, and the ... Note: this reference contains partial transcriptions of Winslow's Mourt's Relations and Bradford's Of Plimoth Plantation, which ... created great hardship for the colonists for many years and was directly cited by William Bradford as a contributing factor to ...
https://en.wikipedia.org/wiki/Plymouth_Colony
Neo-Assyrian EmpireNeo-Assyrian Empire
The sole factor for the higher frequency and more vivid descriptions from the Neo-Assyrian Empire is that the Assyrians were ... Through a well-developed network of spies and informants, Esarhaddon uncovered all of these coup attempts and in 670 BC had a ... such as the Rassam cylinder of Ashurbanipal Rassam cylinder transcription in "CDLI-Archival View". cdli.ucla.edu. "The country ... Perhaps the motivating factor was that Sargon did not feel safe at Nimrud after the early conspiracies against him. As ...
https://en.wikipedia.org/wiki/Neo-Assyrian_Empire
Stafford BeerStafford Beer
Upon returning to England he was assigned to the Human factors Branch of Operations research at the War Office. In 1949, he was ... Although Cybersyn was abandoned after Allende's death during the Pinochet coup in 1973, Beer continued to work in the Americas ... "Designing Freedom" The 1973 Massey Lectures RADIO CANADA INTERNATIONAL TRANSCRIPTION: E1121 "The Real Threat to all We Most ... but was interrupted by the 1973 coup d'état. The Viable System Model (VSM) is a model of the organisational structure of any ...
https://en.wikipedia.org/wiki/Stafford_Beer
Delhi SultanateDelhi Sultanate
This factor also played an important role in the synthesis of cultures. The Hindustani language (Hindi/Urdu) began to emerge in ... Muiz ud-Din Kaiqabad was assassinated and Jalal-ad din took power in a military coup. He was around 70 years old at the time of ... and their chancellery rescripts bore transcriptions in the Devanagari script of the Persian contents. The practice is said to ...
https://en.wikipedia.org/wiki/Delhi_Sultanate
Symphony No. 8 (Schubert)Symphony No. 8 (Schubert)
It could have been a combination of both factors. In 1823, the Graz Music Society gave Schubert an honorary diploma. He felt ... Puech, Benjamin (2019-02-07). "La Symphonie n°8 de Schubert achevée à coups d'intelligence artificielle". Le Figaro (in French ... using the transcription of the first two movements prepared by Hüttenbrenner, his own completion of Schubert's Scherzo, and the ... Rosamunde entr'acte in a transcription by Friedrich Hermann, edited by Goldstone. The work in this completed version was given ...
https://en.wikipedia.org/wiki/Symphony_No._8_(Schubert)
Supreme Court of the United StatesSupreme Court of the United States
What judges have wrought is a coup d'état - slow moving and genteel, but a coup d'état nonetheless. Leiter, Brian (March 19, ... CQ Transcriptions (Senator Kohl) (July 14, 2009). "Key Excerpt: Sotomayor on Bush v. Gore". The Washington Post. Archived from ... partisan and sometimes even political factors playing a role. The fear of mental decline and death often motivates justices to ... CQ Transcriptions (January 13, 2006). "U.S. Senate Judiciary Committee Hearing on Judge Samuel Alito's Nomination to the ...
https://en.wikipedia.org/wiki/Supreme_Court_of_the_United_States
YerevanYerevan
The location of Yerevan itself, is an inspiring factor for the foreigners to visit the city in order to enjoy the view of the ... The transcription of the second cuneiform bu [original emphasis] of the word was very essential in our interpretation as it is ... Serzh Sargsyan announced on the Public Television of Armenia that their respective agencies have prevented an attempted coup ...
https://en.wikipedia.org/wiki/Yerevan
Spanish InquisitionSpanish Inquisition
In addition, the coup that allowed Isabella to take the throne from Joana of Avis and the Catholic Monarchs to marry had ... A literal transcription of the verdict and sentence. If the accused has been accused of more than one thing the sentence ... The use of religion as a unifying factor across a land that was allowed to stay diverse and maintain different laws in other ... The transcription of a new speech by the procurator stating his view of the declarations and wrapping the witnesses' testimony ...
https://en.wikipedia.org/wiki/Spanish_Inquisition
Mary-Claire KingMary-Claire King
"Expression profiling in primates reveals a rapid evolution of human transcription factors". Nature. 440 (7081): 242-245. ... Her time there was cut short when the Chilean government of Salvador Allende was overthrown in a CIA-backed military coup on ... King in recent years has developed a deep interest in studying the genetic factors influencing schizophrenia. In collaboration ... skeptical about the usefulness of genetics in studying more common and complex diseases involving both multiple genetic factors ...
https://en.wikipedia.org/wiki/Mary-Claire_King
Debate over the atomic bombings of Hiroshima and NagasakiDebate over the atomic bombings of Hiroshima and Nagasaki
... and some regard the bombings as the deciding factor, but others see the bombs as a minor factor, and yet others assess their ... "United States Strategic Bombing Survey; Summary Report" (Transcription of original work). Report. United States Government ... Once these coup attempts had failed, senior leaders of the air force and Navy ordered bombing and kamikaze raids on the U.S. ... The mainstream position in the United States from 1945 to the 1960s regarded the bombings as the decisive factor in ending the ...
https://en.wikipedia.org/wiki/Debate_over_the_atomic_bombings_of_Hiroshima_and_Nagasaki
MajapahitMajapahit
After this coup, the war between Demak and Daha receded, since Raden Patah, Sultan of Demak, left Daha alone like his father ... The great prosperity of Majapahit was probably due to two factors. Firstly, the northeast lowlands of Java were suitable for ... Javanese Texts in Transcription (3rd (revised) ed.). The Hague: Martinus Nijhoff. Pigeaud, Theodoor Gautier Thomas (1960b). ... of Majapahit Kingdom A brief history of Majapahit Archived 1 January 2007 at the Wayback Machine A Complete Transcription of ...
https://en.wikipedia.org/wiki/Majapahit
PhilippinesPhilippines
Latitude is an insignificant factor in the variation of temperature while altitude shows greater contrast in temperature. Thus ... However, wealthier families were able to preserve transcriptions of these epics as family heirlooms, particularly in Mindanao. ... and coup attempts. A communist insurgency and a military conflict with Moro separatists persisted, while the administration ... 2001). "Cultural Landmarks and their Interactions with Economic Factors in the Second Millennium in the Philippines". Kinaadman ...
https://en.wikipedia.org/wiki/Philippines
Historiography of the May RevolutionHistoriography of the May Revolution
No religious factors were involved in the revolution: all the revolutionaries and royalists agreed to support Catholicism. ... The fascist author Hugo Wast would describe the Revolution as a military coup carried out by military leaders, and where the ... as the quotes kept do not come from transcriptions or recordings but from memories wrote years later or from oral tradition. ...
https://en.wikipedia.org/wiki/Historiography_of_the_May_Revolution
BangkokBangkok
Education has long been a prime factor in the centralization of Bangkok and will play a vital role in the government's efforts ... The latest gubernatorial election took place on 22 May 2022 after an extended lapse following the 2014 Thai coup d'état, and ... In contrast to the 169-letter-long transcription provided above in this article, the form recorded in the Guinness World ... are major triggering factors. Severe flooding affecting much of the city occurred in 1995 and 2011. In 2011, most of Bangkok's ...
https://en.wikipedia.org/wiki/Bangkok
Spread of the Latin scriptSpread of the Latin script
It was banned in some places such as Libya after Moammar Gaddafi's 1969 coup, in favour of exclusive Arabic script. Since at ... the crucial factor in Latinising these remaining groups that resisted full integration was granting them Roman citizenship ( ... Kabyle intelligentsia began to stimulate the transition and especially since the establishment of a standard transcription for ...
https://en.wikipedia.org/wiki/Spread_of_the_Latin_script
COUP Transcription Factors | Profiles RNS
"COUP Transcription Factors" by people in this website by year, and whether "COUP Transcription Factors" was a major or minor ... COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... "COUP Transcription Factors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "COUP Transcription Factors" by people in Profiles. ...
https://profiles.umassmed.edu/display/120680
Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical...Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical...
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... CTIP1 is a transcription factor that regulates both subtype- and area-specific identity [10,11]. Despite its close homology to ... Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical ... Moreover, the transcription factors CTIP2 and CTIP1 (BCL11B, BCL11A; [69]), which are differentially expressed with subtype- ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254113
COUP-TFII Knock-down Promotes Proliferation and Invasion in Colorectal Cancer Cells via Activation of Akt Pathway and Up...COUP-TFII Knock-down Promotes Proliferation and Invasion in Colorectal Cancer Cells via Activation of Akt Pathway and Up...
COUP transcription factor is a member of the steroid receptor superfamily. Nature 340(6229): 163-166, 1989. PMID: 2739739. DOI ... Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) knock-down enhanced the protein levels of p-Akt, p- ... Knock-down of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoted cell migration and invasion. (A ... The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) belongs to the superfamily ...
https://ar.iiarjournals.org/content/40/1/177
SMART: ZnF C4 domain annotationSMART: ZnF C4 domain annotation
Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1. ... regulation of transcription, DNA-templated (GO:0006355). GO function:. DNA-binding transcription factor activity (GO:0003700), ... They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), ... The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the ...
https://smart.embl.de/smart/do_annotation.pl?DOMAIN=ZnF_C4&START=165&END=236&E_VALUE=1.84e-34&TYPE=SMART&BLAST=AHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKC
Rare variants in NR2F2 cause congenital heart defects in humansRare variants in NR2F2 cause congenital heart defects in humans
COUP Transcription Factor II / genetics* * COUP Transcription Factor II / metabolism * Cell Line ... NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result ...
https://pubmed.ncbi.nlm.nih.gov/24702954/
Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1 | Development ...Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1 | Development ...
The COUP transcription factor UNC-55 has been previously shown to prevent the expression of the DD synaptic pattern in the VD ... ALR-1 acts together with the UNC-55 COUP transcription factor to regulate the differentiation of a GABAergic MN type in C. ... Thus, ALR-1 acts together with a member of the well-conserved COUP transcription factor family to regulate the differentiation ... COUP transcription factors have been implicated in neurogenesis,neuronal differentiation, migration and axonal guidance(Qiu et ...
https://journals.biologists.com/dev/article/132/8/1935/43298/Regulation-of-chemosensory-and-GABAergic-motor
RePub, Erasmus University Repository: Divergence of zebrafish and mouse lymphatic cell fate specification pathwaysRePub, Erasmus University Repository: Divergence of zebrafish and mouse lymphatic cell fate specification pathways
In line with this result, we found that the functionally related transcription factors Coup-TFII and Sox18 are also dispensable ... In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted ...
https://repub.eur.nl/pub/82416
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs.bvs.br/P/mnchg2016.txt
DeCSDeCS
COUP Transcription Factors Entry term(s). COUP TF Proteins COUP-TF Proteins Chicken Ovalbumin Upstream Promoter Transcription ... Chicken Ovalbumin Upstream Promoter-Transcription Factors. Transcription Factors, COUP. Tree number(s):. D12.776.260.643.039. ... Facteurs de transcription COUP-TF Entry term(s):. COUP TF Proteins. COUP-TF Proteins. Chicken Ovalbumin Upstream Promoter ... COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ...
https://decs.bvsalud.org/en/ths/resource/?id=50978
保健管理センター - 研究成果 - Keio University
COUP Transcription Factors 100% * Steroidogenic Factor 1 86% * Cytochrome P-450 CYP11B2 63% ... Ubc9 and protein inhibitor of activated STAT 1 activate chicken ovalbumin upstream promoter-transcription factor I-mediated ... Factor XII Shizuoka, a novel mutation (Ala392Thr) identified and characterized in a patient with congenital coagulation factor ... COUP-TF and transcriptional co-regulators in adrenal steroidogenesis. Shibata, H., Kobayashi, S., Kurihara, I., Suda, N., ...
https://keio.pure.elsevier.com/ja/organisations/3012-health-center/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&page=6
A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans. | Miller Lab | Vanderbilt...
Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit ... This remodeling program is blocked in Ventral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream ... Moreover, the well established roles of these conserved transcription factors in mammalian neural development suggest that a ... and transcription factors. We show that one of these targets, the Iroquois-like homeodomain protein, IRX-1, functions as a key ...
https://lab.vanderbilt.edu/miller-lab/publication/a-transcriptional-program-promotes-remodeling-of-gabaergic-synapses-in-caenorhabditis-elegans/
Categories XXXV PhD Course Archive | Ph.D. Program in Translational and Molecular Medicine (Dimet)Categories XXXV PhD Course Archive | Ph.D. Program in Translational and Molecular Medicine (Dimet)
Project Title: Role of the transcription factor COUP-TFII in early erythropoiesis. ...
http://www.dimet.org/portfolio_category/xxxv-phd-course/
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
... relies on COUP-TFI (chicken ovalbumin upstream promoter-transcription factor I), a patterning transcription factor with graded ... Thus, we conclude that a sharp boundary requires a subtle interplay between patterning transcription factors and differential ... COUP-TFI specifies the medial entorhinal cortex identity and induces differential cell adhesion to determine the integrity of ... Neocórtex , Fator I de Transcrição COUP/metabolismo , Adesão Celular , Córtex Entorrinal , Neocórtex/metabolismo , Fatores de ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Patterson,+Denis
UniProt ID F7- Growth Factors, Growth Hormones, Purified Proteins, Dominant Negative Clones, Constitutively Active Clones-...UniProt ID F7- Growth Factors, Growth Hormones, Purified Proteins, Dominant Negative Clones, Constitutively Active Clones-...
COUP transcription f. xPF7CII1Mu. Size: 0.2-1mg. Price Request Quote. Request Quote. Details. ...
https://lifeome.com/protein-expression-uniprot-id-f7-c-21_356_399.html
CDX2 Transcription Factor | Colorado PROFILES
COUP Transcription Factors. *Cyclic AMP Receptor Protein. *E2F Transcription Factors. *Early Growth Response Transcription ... "CDX2 Transcription Factor" by people in this website by year, and whether "CDX2 Transcription Factor" was a major or minor ... "CDX2 Transcription Factor" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA ...
https://profiles.ucdenver.edu/display/21256831
Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex. -...
COUP-TF interacting protein 2) have been shown to be required for callosal and corticospinal axon growth respectively from ... Our work shows that although expression of these transcription factors correlates well with the appearance of directed axon ... The transcription factors Satb2 (special AT-rich sequence binding protein 2) and Ctip2 ( ... The transcription factors Satb2 (special AT-rich sequence binding protein 2) and Ctip2 (COUP-TF interacting protein 2) have ...
https://www.stemcells.ox.ac.uk/publications/222364
MH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs2018.bvsalud.org/I/mnchg2016.txt
MH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs2019.bvsalud.org/E/mnchg2016.txt
MH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs2016.bvsalud.org/E/mnchg2016.txt
MH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs2020.bvsalud.org/E/mnchg2016.txt
MH DELETED MN ADDED MN
COUP Transcription Factor I D12.776.260.698.209.39.249 D12.776.260.643.39.249 D12.776.930.669.209.39.249 COUP Transcription ... Transcription Factor Brn-3 D12.776.930.632.625 D12.776.930.710.625 Transcription Factor Brn-3A D12.776.930.632.625.500 D12.776. ... 930.710.625.500 Transcription Factor Brn-3B D12.776.930.632.625.750 D12.776.930.710.625.750 Transcription Factor Brn-3C D12.776 ... Octamer Transcription Factor-1 D12.776.930.632.500.100 D12.776.930.710.500.100 Octamer Transcription Factor-2 D12.776.930.632. ...
https://decs2017.bvsalud.org/E/mnchg2016.txt
Trainee Merit Award - American Society of Andrology
THE TRANSCRIPTION FACTOR MEF2 IS A NOVEL REGULATOR OF GSTA1 EXPRESSION IN MA-10 LEY-DIG CELLS ... THE NUCLEAR RECEPTOR COUP-TFII ACTIVATES STAR GENE TRANSCRIPTION IN COOPERATION WITH CAMKI IN LEYDIG CELLS ... VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION FROM NEUROENDOCRINE (NE) CELLS IS ASSOCIATED WITH INVASIVE PHENOTYPE AND ... MEF2 AND COUP-TFII COOPERATE TO REGULATE AKR1C14 GENE EXPRESSION IN MOUSE MA-10 LEYDIG ...
https://andrologysociety.org/trainee-merit-award/
GSE37605 TREG VS TCONV NOD FOXP3 FUSION GFP UPGSE37605 TREG VS TCONV NOD FOXP3 FUSION GFP UP
MAF bZIP transcription factor F [So.... MAS1. 4142. MAS1. MAS1 proto-oncogene, G protein-coup.... ... TFT: Transcription Factor Targets TFT:GTRD: GTRD TFT:TFT_Legacy: TFT_Legacy C4: Computational CGN: Cancer Gene Neighborhoods CM ...
https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE37605_TREG_VS_TCONV_NOD_FOXP3_FUSION_GFP_UP.html
FOXP2FOXP2
transcription factor activity. • protein binding. • zinc ion binding. • transcription repressor activity. • protein ... COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone ( ... transcription. • regulation of transcription, DNA-dependent. • negative regulation of transcription. • caudate nucleus ... Transcription factors and intracellular receptors. (1) Basic domains. (1.1) Basic leucine zipper (bZIP). Activating ...
https://www.bionity.com/en/encyclopedia/FOXP2.html
TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGENTRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN
RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M. RT A chicken ovalbumin upstream promoter transcription factor I (COUP ... IN T08505 COUP-TF1; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T10210 Evi-1; human, Homo sapiens. IN T34374 ... TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN. AC T28757 XX ID T28757 XX DT 17.10.2006 (created); sou ... complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). RL J. Biol. Chem. ...
http://factor.genexplain.com/cgi-bin/transfac_factor/getTF.cgi?AC=T28757
Purchase Zion Labs Oxandrolone OnlinePurchase Zion Labs Oxandrolone Online
Quite different from upstream promoter transcription factor I (COUP-TF1), which itself is coactivated by the the back of the ...
https://www.chicagonewsdaily.com/zion-labs-oxandrolone.html
Transcriptome analysis of radish sprouts hypocotyls reveals the regulatory role of hydrogen-rich water in anthocyanin...Transcriptome analysis of radish sprouts hypocotyls reveals the regulatory role of hydrogen-rich water in anthocyanin...
In addition, other transcription factors (such as NAC, bZIP and TCP) might participate in HRW-promoted anthocyanin biosynthesis ... The MYB-bHLH-WD40 complex accounted for the majority of the transcription factors found to be involved in anthocyanin ... In addition, the co-up-regulation of NAC and MYB implied that the activation of MYB might be associated with NAC. In our study ... Expression profiling of transcription factors associated with anthocyanin biosynthesis. Transcription factors play important ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-018-1449-4
3,3-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal...3,3'-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal...
The expression of several growth inhibitory and pro-apoptotic factors such as activating transcription factor 3(ATF3 ), p21, ... COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. Breast ... These natural compounds are also effective modulators of transcription factors and non-coding RNAs. These effects explain their ... Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor response elements and half-sites, and ...
https://cdrjournal.com/article/view/3692
Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells | BMC Genomics | Full TextTranscriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells | BMC Genomics | Full Text
The "Transcription Factor" column identifies individual transcription factors recognized by GeneCodis as capable of controlling ... Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL: COUP-TFI ... The "Transcription Factor" column identifies individual transcription factors recognized by GeneCodis as capable of controlling ... Table 1 Transcription factors with recognition binding sites located in the mPttg1 promoter Full size table. ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-1019
ProteinsRegulatesHomeodomain transcription factorGenesChicken ovalbuProteinPromoterNR2F2TranscriptionalBZIPHomologMammalianTumorMRNAGene expressionDescriptorReverse transcriptionDifferentiationProx1PhysiologicalMammalsInhibitRolesNuclear factorBindExpressionProgressionFamilyMechanismsInvestigationHumanInvolvementFoundCellFormEarlyStudiesRisk factors
Proteins3
  • Forkhead box C1 (FOXC1), a member of the forkhead box transcription factor family, is an important transcriptional regulator of crucial proteins involved in several cancers ( 16 ). (iiarjournals.org)
  • In the CYTOPLASM , I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)
  • of the transcription factor proteins (see ?Zinc Fingers? (infoholix.net)
Regulates6
  • Background/Aim: The chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) regulates cancer cell proliferation and invasion via complex molecular mechanisms. (iiarjournals.org)
  • An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA. (ucdenver.edu)
  • In Drosophila , there is now compelling evidence that individual multipotent neuroblasts express a sequence of progenitor transcription factors which, in turn, regulates the postmitotic transcription factors that specify neuronal/glial temporal identities. (silverchair.com)
  • EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor. (jefferson.edu)
  • Recent studies suggest that glucose regulates gene transcription in the liver. (omeka.net)
  • A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. (omeka.net)
Homeodomain transcription factor1
  • In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. (eur.nl)
Genes10
  • The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. (embl.de)
  • These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. (embl.de)
  • Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely undefined. (vanderbilt.edu)
  • We exploited this UNC-55 function to identify downstream synaptic remodeling genes that encode a diverse array of protein types including ion channels, cytoskeletal components, and transcription factors. (vanderbilt.edu)
  • The regulatory genes, which regulate anthocyanin biosynthesis at the transcriptional level, encode transcription factors (TFs). (biomedcentral.com)
  • It represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES . (nih.gov)
  • Hundreds of genes have been identified, including several transcription factors, which have expression patterns tightly correlated with ESC differentiation. (proteinlounge.com)
  • Using classic molecular biology methods (gene promoter characterization) and the use of various cell line models, we have contributed significantly to a better understanding of the genes and network of genes targeted by GATA factors. (ulaval.ca)
  • Continuing along this path, we are now very interested in defining: 1) the sub-group of genes directly targeted by GATA factors (i.e. those requiring a direct GATA bond) and 2) how GATA genes are regulated (at the transcriptional and post-translational levels). (ulaval.ca)
  • It also inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha, all of which are involved in the early stages of T-cell activation. (medscape.com)
Chicken ovalbu4
  • The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) belongs to the superfamily of steroid/thyroid hormone receptors with highly conserved motifs ( 7 ). (iiarjournals.org)
  • This remodeling program is blocked in Ventral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream promoter transcription factor) homolog, UNC-55. (vanderbilt.edu)
  • 19112178 . RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M. RT A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). (genexplain.com)
  • Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription. (keio.ac.jp)
Protein6
  • The protein levels of forkhead box C1 (FOXC1), p-Akt, p-glycogen synthase kinase-3β (p-GSK-3β), and β-catenin, which are known to be involved in cell proliferation and invasion, were significantly increased in COUP-TFII shRNA-HT-29 cells. (iiarjournals.org)
  • The transcription factors Satb2 (special AT-rich sequence binding protein 2) and Ctip2 (COUP-TF interacting protein 2) have been shown to be required for callosal and corticospinal axon growth respectively from subtypes of cerebral cortex projection neurons. (ox.ac.uk)
  • MAS1 proto-oncogene, G protein-coup. (gsea-msigdb.org)
  • The formation of tumor resistance is complex and based on intrinsic and acquired resistance mechanisms which include increased efflux of chemotherapeutics (e.g., by ABC transporters), increased DNA repair, mutation or alteration of drug targets, epigenetic mechanisms such as epigenetic regulation of gene expression and/or of protein drug targets, induction of senescence, factors in the tumor microenvironment, and epithelial-to-mesenchymal transition [ 4 , 5 ] . (cdrjournal.com)
  • Atchison L, Ghias A, Wilkinson F, Bonini N, Atchison ML. Transcription factor YY1 functions as a PcG protein in vivo. (jefferson.edu)
  • Steroid hormones act on cells by passing through the cell membrane, entering the nucleus, binding to DNA, and initiating gene transcription and protein production, hgh fragment 176-191 cycle length. (the-seeds.net)
Promoter2
  • Quite different from upstream promoter transcription factor I (COUP-TF1), which itself is coactivated by the the back of the spinal canal between adjacent spinous processes (bony projection of the vertebra) or laminae (posterior wall of the vertebra) to reach the epidural space. (chicagonewsdaily.com)
  • Analysis of the mPttg1 promoter region identified specific recognition sites for numerous transcription factors which were also found to be differentially expressed in RasGrf1 KO pancreatic islets and are known to be relevant for Ras-ERK signaling as well as beta cell function. (biomedcentral.com)
NR2F22
  • NR2F2 encodes a pleiotropic developmental transcription factor, and decreased dosage of NR2F2 in mice has been shown to result in abnormal development of atrioventricular septa. (nih.gov)
  • Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children. (cdc.gov)
Transcriptional1
  • Our work shows that although expression of these transcription factors correlates well with the appearance of directed axon growth during cortical development, the transcriptional code underlying the bi-directional axonal projections of early neocortical neurons is not likely to be the result of Satb2/Ctip2 co-expression. (ox.ac.uk)
BZIP2
  • MAF bZIP transcription factor F [So. (gsea-msigdb.org)
  • In addition, other transcription factors (such as NAC, bZIP and TCP) might participate in HRW-promoted anthocyanin biosynthesis. (biomedcentral.com)
Homolog1
Mammalian1
  • Moreover, the well established roles of these conserved transcription factors in mammalian neural development suggest that a similar cascade may also control synaptic plasticity in more complex nervous systems. (vanderbilt.edu)
Tumor4
  • Recent reports have shown that COUP-TFII significantly contributes to the regulation of metabolism and angiogenesis in metastasis, tumor progression, and tumor formation ( 9 ). (iiarjournals.org)
  • Evidence suggests that COUP-TFII promotes tumor progression by enhancing cell proliferation and invasion ( 10 , 11 ). (iiarjournals.org)
  • However, COUP-TFII has also been reported to act as a tumor suppressor. (iiarjournals.org)
  • The current state of the anticancer activities of DIM and its synthetic derivatives is presented in this review with a focus on cancer drug resistance, tumor growth inhibition, and new insights concerning their effects on signaling pathways and transcription factors. (cdrjournal.com)
MRNA1
  • Building on recently identified central molecular controls over SCPN development, we used a combination of synthetic modified mRNA (modRNA) for Fezf2 , the central transcription factor controlling SCPN specification, and small molecule screening to investigate whether distinct chromatin modifiers might complement Fezf2 functions to promote SCPN-specific differentiation by mouse ES (mES)-derived cortical-like neurons. (plos.org)
Gene expression1
  • Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. (medscape.com)
Descriptor1
  • COUP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Reverse transcription3
  • Considering the very short generation time for a virus, and the high error rate associated with the reverse transcription step of HBV replication, decades of HBV infection are probably equivalent to million years of human evolution. (medsci.org)
  • By reverse transcription PCR, tissues from 32 (62%) case-patients (brains from 8 infants with microcephaly and placental/fetal tissues from 24 women) were positive for Zika virus. (cdc.gov)
  • Tissue-based reverse transcription PCR extends the time frame of Zika virus detection in congenital and pregnancy-associated infections. (cdc.gov)
Differentiation2
  • Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
  • In fact, the range of action of GATA factors now includes gonads where they control the early development of testis and ovaries, sexual differentiation and steroidogenesis. (ulaval.ca)
Prox11
  • Prox1, an early specific marker for developing liver and pancreas in foregut endoderm has recently been shown to interact with alpha-fetoprotein transcription factor and repress cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription. (omeka.net)
Physiological1
  • During the pas years, our main objective was to understand the physiological roles played by the transcription factor family, GATA. (ulaval.ca)
Mammals1
  • Here,we examine the hypothesis that the regulatory principles underlying this mode of temporal specification are shared between insects and mammals, even if some of the factors themselves are not. (silverchair.com)
Inhibit2
  • In addition, ectopic expression of COUP-TFII is reported to inhibit liver metastasis in vivo , as well as cell proliferation, migration and invasion in vitro ( 13 ). (iiarjournals.org)
  • Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. (omeka.net)
Roles1
  • Because of their well-established role in other tissues such as the heart and digestive system, we proposed that GATA factors could play roles of the same importance in the developmental and functional regulation of gonads. (ulaval.ca)
Nuclear factor1
  • Indoles are also prominent dietary compounds, and indole alkaloid derivatives of Brassica species such as indole glucosinolates, indole-3-carbinol (I3C), and 3,3'-diindolylmethane (DIM) display distinct anticancer activities based on apoptosis induction as well as suppression of phosphatidyl-inositol-3-kinase(PI3K)/Akt and nuclear factor κB (NF-κB) signaling [Figure 1] [ 11 - 13 ] . (cdrjournal.com)
Bind1
  • Transcription factors that form transcription initiation complexes on DNA , bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. (nih.gov)
Expression3
  • For example, overexpression of COUP-TFII in breast cancer cell lines leads to increased expression of cyclin D1 and p21, resulting in reduced cell growth and plating efficiency ( 12 ). (iiarjournals.org)
  • In line with this, expression of COUP-TFII has been shown to be reduced in human gastric cancer cells compared to normal cells ( 13 ). (iiarjournals.org)
  • Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex. (ox.ac.uk)
Progression1
  • Direct factor Xa inhibition attenuates acute lung injury progression via modulation of the PAR-2/NF-κB signaling pathway. (e-century.us)
Family2
  • FOXP2 is a member of the large FOX family of transcription factors . (bionity.com)
  • Heterozygous 17-bp deletion in the forkhead transcription factor gene, FOXL2, in a Japanese family with blepharophimosis-ptosis-epicanthus inversus syndrome. (cdc.gov)
Mechanisms1
  • In order to overcome these resistance factors, thorough knowledge of these mechanisms is necessary in addition to the identification of new drugs. (cdrjournal.com)
Investigation1
  • Thus, further investigation into the role of COUP-TFII in CRC is required. (iiarjournals.org)
Human2
  • Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. (omeka.net)
  • It is known that functional deficiencies in certain GATA factors are associated to human diseases and we believe the same applies to the reproductive system. (ulaval.ca)
Involvement1
  • Our recent work has already highlighted the potential involvement of these factors in various pathologies such as breast cancer, endometriosis, polycystic ovarian syndrome and cases of sexual reversion associated to AMH production deficiency. (ulaval.ca)
Found2
  • In line with this result, we found that the functionally related transcription factors Coup-TFII and Sox18 are also dispensable for lymphangiogenesis. (eur.nl)
  • The MYB-bHLH-WD40 complex accounted for the majority of the transcription factors found to be involved in anthocyanin biosynthesis, and levels of transcripts for this complex were in accordance with the anthocyanin concentrations observed. (biomedcentral.com)
Cell3
  • We aimed to investigate whether COUP-TFII modulates proliferation and invasion of the colorectal adenocarcinoma cell line HT-29. (iiarjournals.org)
  • Results: Cell proliferation and invasion were significantly enhanced in COUP-TFII shRNA-HT-29 cells. (iiarjournals.org)
  • Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor. (e-century.us)
Form1
  • Together, these factors form a ternary complex, the MYB-bHLH-WD repeat (MBW) complex, to orchestrate anthocyanin biosynthesis. (biomedcentral.com)
Early1
  • Role of the transcription factor COUP-TFII in early erythropoiesis. (dimet.org)
Studies1
  • Our previous studies showed that COUP-TFII is a good prognostic factor in CRC patients ( 14 , 15 ). (iiarjournals.org)
Risk factors1
  • Atrial fibrillation, rheumatic heart disease, and valvular prosthetics are risk factors for which type of stroke? (onlinebestessays.com)