A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.
A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The part of the face above the eyes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.
A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.
Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.
Pathological processes of the KIDNEY or its component tissues.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Educational institutions for individuals specializing in the field of pharmacy.
Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.
Test designed to identify students suitable for admission into a graduate or undergraduate curriculum.
Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.
Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.
Facilities for the preparation and dispensing of drugs.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.
The field of biology which deals with the process of the growth and differentiation of an organism.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Databases devoted to knowledge about specific genes and gene products.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
The systematic study of the complete DNA sequences (GENOME) of organisms.

COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site. (1/143)

The formation of various tissues requires close communication between two groups of cells, epithelial and mesenchymal cells. COUP-TFs are transcription factors which have been shown to have functions in embryonic development. COUP-TFI is expressed mainly in the nervous system, and its targeted deletion leads to defects in the central and peripheral nervous systems. COUP-TFII is highly expressed in the mesenchymal component of the developing organs. A null mutation of COUP-TFII results in the malformation of the heart and blood vessels. From their expression pattern, we proposed that COUP-TFs regulate paracrine signals important for mesenchymal cell-epithelial cell interactions. In order to identify genes regulated by COUP-TF in this process, a rat urogenital mesenchymal cell line was stably transfected with a COUP-TFI expression vector. We found that NGFI-A, a gene with important functions in brain, organ, and vasculature development, has elevated mRNA and protein levels upon overexpression of COUP-TFI in these cells. A study of the promoter region of this gene identified a COUP-TF-responsive element between positions -64 and -46. Surprisingly, this region includes binding sites for members of the Sp1 family of transcription factors but no COUP-TF binding site. Mutations that abolish the Sp1 binding activity also impair the transactivation of the NGFI-A promoter by COUP-TF. Two regions of the COUP-TF molecule are shown to be important for NGFI-A activation: the DNA binding domain and the extreme C terminus of the putative ligand binding domain. The C-terminal region is likely to be important for interaction with coactivators. In fact, the coactivators p300 and steroid receptor activator 1 can enhance the transactivation of the NGFI-A promoter induced by COUP-TFI. Finally, we demonstrated that COUP-TF can directly interact with Sp1. Taken together, these results suggest that NGFI-A is a target gene for COUP-TFs and that the Sp1 family of transcription factors mediates its regulation by COUP-TFs.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/143)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene. (3/143)

Nuclear orphan receptors are known to be important mediators of neurogenesis, but the target genes of these transcription factors in the vertebrate nervous system remain largely undefined. We have previously shown that a 500-base pair fragment in the first intron of the GRIK5 gene, which encodes the kainate-preferring glutamate receptor subunit KA2, down-regulates gene expression. In our present studies, mutation of an 11-base pair element within this fragment resulted in a loss of nuclear protein binding and reverses negative regulation by the intron. Using yeast one-hybrid screening, we have identified intron-binding proteins from rat brain as COUP-TFI, EAR2, and NURR1. Gel shift studies with postnatal day 2 rat brain extract indicate the presence of COUP-TFs, EAR2, and NURR1 in the DNA-protein complex. Competition assays with GRIK5-binding site mutations show that the recombinant clones exhibit differential binding characteristics and suggest that the DNA-protein complex from postnatal day 2 rat brain may consist primarily of EAR2. The DNA binding activity was also observed to be enriched in rat neural tissue and developmentally regulated. Co-transfection assays showed that recombinant nuclear orphan receptors function as transcriptional repressors in both CV1 cells and rat CG4 oligodendrocyte cells. Direct interaction of the orphan receptors with and relief of repression by TFIIB indicate likely role(s) in active and/or transrepression. Our findings are thus consistent with the notion that multiple nuclear orphan receptors can regulate the transcription of a widely expressed neurotransmitter receptor gene by binding a common element in an intron and directly modulating the activity of the transcription machinery.  (+info)

Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. (4/143)

We previously identified various upstream and downstream regulatory elements and factors important for hepatic expression of the human angiotensinogen (ANG) gene, the precursor of vasoactive octapeptide angiotensin II. In the present study, to further investigate the molecular mechanism of human ANG transcriptional regulation, we generated transgenic mice carrying the fusion gene composed of the 1. 3-kilobase promoter of the human ANG gene, its downstream enhancer, and the chloramphenicol acetyltransferase reporter gene. Because expression of the chloramphenicol acetyltransferase gene was observed strongly in the liver and weakly in the kidney, we suspected that hepatocyte nuclear factor (HNF) 4 with a tissue expression pattern similar to that of the reporter gene would regulate ANG transcription. In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. Furthermore, COUP-TF dramatically decreased the human ANG transcription in the mouse liver by the Helios Gene Gun system in vivo. These results suggest that an interplay between HNF4 and COUP-TF could be important in hepatic human ANG transcription.  (+info)

Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (5/143)

The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.  (+info)

The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. (6/143)

Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differentiation and premature cell death during corticogenesis. Our results indicate that the subplate neuron defects lead to the failure of guidance and innervation of thalamocortical projections. Thus, our findings demonstrate a critical role of the subplate in early corticothalamic connectivity and confirm the importance of afferent innervation for the survival of layer IV neurons. These results also substantiate COUP-TFI as an important regulator of neuronal development and differentiation.  (+info)

Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. (7/143)

Retinoic acid receptor beta (RARbeta) plays a critical role in mediating the anticancer effects of retinoids. Expression of RARbeta is highly induced by retinoic acid (RA) through a RA response element (betaRARE) that is activated by heterodimers of RARs and retinoid X receptors (RXRs). However, RARbeta induction is often lost in cancer cells despite expression of RARs and RXRs. In this study, we provide evidence that orphan receptor COUP-TF is required for induction of RARbeta expression, growth inhibition, and apoptosis by RA in cancer cells. Expression of COUP-TF correlates with RARbeta induction in a variety of cancer cell lines. In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARbeta expression, growth inhibition, and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects. In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARbeta promoter in a RA- and RARalpha-dependent manner. By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARbeta promoter. The binding of COUP-TF to the DR-8 element synergistically increases the RA-dependent RARalpha transactivation function by enhancing the interaction of RARalpha with its coactivator CREB binding protein. These results demonstrate that COUP-TF, by serving as an accessory protein for RARalpha to induce RARbeta expression, plays a critical role in regulating the anticancer activities of retinoids.  (+info)

The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. (8/143)

Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system and plays a direct role in the pathogenesis of AIDS dementia. However, the molecular mechanisms underlying HIV-1 expression in the central nervous system are poorly understood. We have recently reported that the nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF), an orphan member of the nuclear receptor superfamily, is an activator of HIV-1 gene transcription. Here, our results show that COUP-TF stimulates HIV-1 transcription in primary cultured human microglial cells, the primary target for HIV-1 infection in brain. Run-on assays indicated that COUP-TF acts on the initiation step of transcription. Results from reverse transcription-polymerase chain reaction and immunocytochemistry analysis further revealed the importance of this factor by demonstrating that overexpression of COUP-TF leads to initiation of viral replication in primary HIV-infected human microglia. In addition, COUP-TF is able to physically interact and cooperate with the viral transactivator Tat. The combination of COUP-TF and Tat leads to NF-kappaB- and Sp1-independent enhanced transcriptional stimulation. In vitro binding studies showed that COUP-TF interacts with Tat through amino acids within the N-terminal DNA-binding domain of COUP-TF. Amino acids 48-72 in the basic and C-terminal regions of Tat are required for the binding of Tat to COUP-TF. These results suggest that COUP-TF is an essential transcription factor involved in HIV-1 expression in microglia and reveal a novel interplay of Tat and COUP-TF during regulation of viral expression.  (+info)

The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
In the mosquito Aedes aegypti, vitellogenesis is activated via an ecdysteroid hormonal cascade initiated by a blood meal. The functional ecdysone receptor is a heterodimer composed of the ecdysone receptor (EcR) and ultraspiracle, the homolog of the retinoid X receptor. The precise tuning of this hormonal response requires participation of both positive and negative transcriptional regulators. In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor complex-mediated transactivation in vitro and in vivo. Here we report the cloning and characterization of the Svp homolog in mosquito Aedes aegypti, AaSvp. It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. AaSvp transcripts and protein are present in the fat body at high levels from the state of arrest to about 60 h post blood meal. AaSvp binds strongly to a variety of direct repeats of the sequence AGGTCA, but weakly to ...
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions. In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. NR2F6 serves as an antigen receptor signaling threshold-regulated barrier against autoimmunity where NR2F6 is part of a negative feedback loop that limits inflammatory tissue damage induced by weakly immunogenic antigens such as self-antigens. Under such low affinity antigen receptor stimulation, NR2F6 appears as a prototypical repressor that functions to
AbstractThe hippocampus (HP), a medial cortical structure, is subdivided into a distinct dorsal (septal) and ventral (temporal) portion, which is separated by an intermediate region lying on a longitudinal curvature. While the dorsal portion is more dedicated to spatial navigation and memory, the mo
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor
Looking for online definition of COUP-TF I in the Medical Dictionary? COUP-TF I explanation free. What is COUP-TF I? Meaning of COUP-TF I medical term. What does COUP-TF I mean?
Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
J:112461 Tang LS, Alger HM, Pereira FA, COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006 Sep;133(18):3683-93 ...
Synonyms for Sport coupé in Free Thesaurus. Antonyms for Sport coupé. 5 words related to coupe: auto, automobile, car, motorcar, machine. What are synonyms for Sport coupé?
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] ...
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1. Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metabolism. 2008; 7:86-94. PMCID:PMC2278019. 2. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA. 2008; 105: 2421-2426. PMCID:PMC2268152. 3. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, and Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010. 143; 156-169. PMCID:PMC2950833. 4. Eguchi J, Wang X, Yu S, Kershaw EE, Chui PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, and Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metabolism. 2011; 13: 249-259. PMCID: PMC3063358. 5. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong S-E, and Rosen ED. FOSL2 promotes adipocyte-specific leptin gene ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Regional and cell-type specification during embryogenesis are often coupled to expression of TFs that are restricted to specific progenitor domains. Here, we found that Nkx2-1 restricts the expression of Coup-TF1/2 in the MGE to an arc that extended from a small rostrodorsal domain to a larger caudoventral domain (Fig. 1; Fig. S1B,D,H,K,L). The Coup-TF1/2+ MGE domain was complementary to an Otx2+ domain (Fig. S1B-E), where Otx2 represses Coup-TF1 MGE expression (Hoch et al., 2015a,b).. Our data support a model in which the Coup-TF1/2+ MGE domain is biased towards generating SST+ CINs (Fig. 2; Fig. S3A-C), as well as cholinergic and pallidal neurons (Fig. S4). These conclusions differ from other publications regarding the major location for the origin of SST+ interneurons, and provide evidence for a Coup-TF1/2-dependent activation of Sox6 expression that promotes SST+ interneuron development.. Multiple lines of evidence show that Coup-TF1/2 have key roles in promoting SST+ interneuron ...
Alias: NR2F2, ARP1, ARP-1, COUP transcription factor II, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, COUPTFII, COUP transcription factor 2, EAR3, NF-E3, SVP40, COUPTF-II, TFCOUP2 ...
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This NR2F2 / COUP2 polyclonal antibody from Active Motif has been validated for use in Chromatin Immunoprecipitation (ChIP) and Western blot.
In this video, Alex explains why there has been a coup détat against our Constitutional Republic, and breaks down why the office of the presidency is becoming dictatorial.. Read: Retired Army Captain Warns DHS Acquisitions are bold threat of war Against the American People - http://www.infowars.com/retired-army-captain-warns-recent-dhs-acquisitions-are-bold-threat-of-war… ...
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Besidin information about active ingredients, pharmaceutical forms and doses by Coup, Besidin indications, usages and related health products lists
2011 was a year of bigger deals and fewer exits for venture-backed companies, according to data being released today by Dow Jones VentureSource.
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
Looking for online definition of Coup d'etát in the Medical Dictionary? Coup d'etát explanation free. What is Coup d'etát? Meaning of Coup d'etát medical term. What does Coup d'etát mean?
LXR α 0h 4h 8h 18h 1D 2D 3D 4D 5D 6D 7D 8D h 2d d Induction MediumDifferentiation Medium NR Expression during Adipogenesis of 3T3-L1 Cells (2) Fu et al., Mol. Endo. 19: 2437 (2005) Nur77 PPAR γ NUR77 LXR  PPAR 
Former House Majority Leader Dick Armey (R-Texas), who abruptly resigned as head of Tea Party group FreedomWorks, brought in an assistant with a gun in an apparent coup attempt at the group, according to a report in the Washington Post. | this curious life
The Nigerian military successfully staged their fifth coup in 17 years on December 31.They seized power from President Shehu Shagari, ending four years of democratic civilian rule.The army, led by Major-General Mohammed Buhari; 41, said in an early-morning…
The Brazilian Coups Image Problem from Boston Review. New leaks prove the impeachment is intended to protect corrupt politicians.
The crash has laid bare many unpleasant truths about the United States. One of the most alarming, says a former chief economist of the International Monetary Fund, is that the finance industry has effectively captured our government—a state of affairs that more typically describes emerging markets, and is at the center of many emerging-market crises. If the IMF’s staff could speak freely about the U.S., it would tell us what it tells all countries in this situation: recovery will fail unless we break the financial oligarchy that is blocking essential reform. And if we are to prevent a true depression, we’re running out of time.
After months of political crisis, the generals declare martial law. They claim theyre just making peace, not running the country.
In a major coup the Socceroos will have the opportunity to compete with the best in the world next year after a historic agreement.
1.School of Biology, Department of Biomedical Engineering and College of ComputingGeorgia Institute of TechnologyAtlanta, GeorgiaUSA ...
The bars message will be unmistakable: Mr. DeRossi has commissioned artists to recreate some of the more clever signs that protesters have been brandishing at anti-Trump rallies and marches over the past few months. At Coup, they will become décor.. Coup wont be the first bar opened in protest of President Trump. During the week before the election and the week of the inauguration, Barrel, a saloon in Washington, converted its basement into a jokey, for-profit Trump-themed pop-up, with drinks like the Moscow Mole. Bar Ilegal, another Washington pop-up, sponsored by Ilegal Mezcal, ran for a week before the election, with all profits going to Niños de Guatemala, a school for underprivileged children in that country.. There are certainly many bars across America with a pro-Trump atmosphere. But few on either side of the political divide are as ambitious as Coup.. Coup will have two bars, one reserved for a rotating roster of guest bartenders, who will put in from one to several nights work. ...
The Cayenne Coupé models have active aerodynamics, as do the Cayenne Turbo and Cayenne Turbo S E-Hybrid. Active slats in the front air intakes enable the combustion engine to be efficiently cooled. In the Cayenne Coupé models, the adaptive rear spoiler extends by 135mm, also ensuring the appropriate downforce for every situation. While the adaptive roof spoiler on the Cayenne Turbo provides stabilising contact pressure on the rear axle while driving. In the air brake position, this helps to shorten braking distances ...
The Cayenne Coupé models have active aerodynamics, as do the Cayenne Turbo and Cayenne Turbo S E-Hybrid. Active slats in the front air intakes enable the combustion engine to be efficiently cooled. In the Cayenne Coupé models, the adaptive rear spoiler extends by 135mm, also ensuring the appropriate downforce for every situation. While the adaptive roof spoiler on the Cayenne Turbo provides stabilising contact pressure on the rear axle while driving. In the air brake position, this helps to shorten braking distances ...
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
Turkeys mayhem started with an attempted coup, followed by a chaotic night of gunfire, violence and uncertainty. Read a breakdown of how the events unfolded.
Coup De Gráce testo canzone cantato da 360: Ayy They wanna know where 6 at (6 at) When I hit em with this track they would likely...
Turkey has reportedly made a formal request to the United States for the arrest of U.S.-based Turkish cleric Fethullah Gulen on charges of orchestrating an attempted military coup on July 15. Mana Rabiee reports.}
Intelligence sources say the Bangladesh coup attempt last month was fueled by retired officers campaigning to introduce sharia law. The news raises concern about political instability in the region.
Deep State Panics Over NY Times Confirming Active FBI Coup Against Trump https://youtu.be/2yHLSIhMYRM Lets get busy, patriots. Time to educate and enlighten your circle of influence about these traitors and international conspirators who attempted to overthrow Donald J. Trump. This is truth history. James Comey John Brennan James Clapper Susan Rice Andrew McCabe Robert Mueller…
WHY WE LOVE IT Bread van of-fers a slice of the VW ac-tion at low prices The Polo MkII was a prac-ti-cal re-think of the orig-i-nal VW su-per-mini (1975-1981), and was ini-tially avail-able with a squared-off back end and big rear win-dows, like a com-pact es-tate car that fans af-fec-tion-ately named the bread van. The ar-rival of the coupé ver-sion from 1983 of-fered a more tra-di-tional slop-ing hatch-back style.. En-gine sizes ranged from 895cc to 1272cc, but who can for-get the leg-endary su-per-charged 116bhp G40 in-tro-duced in 1991, thats ca-pa-ble of a top speed of 120mph?. Per-haps spurred on by the G40, Polo MkIIs have a strong fol-low-ing - par-tic-u-larly among mod-i-fiers - though theres good avail-abil-ity of most types and some re-ally great bar-gains to be had out there. BUY-ING TIPS. As ever, rust is the big po-ten-tial prob-lem - take a good look at those door bot-toms. Also check for signs of ac-ci-dent dam-age, break-ins and poor re-pair work.. Reg-u-lar oil changes ...
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
Thousands of public servants dismissed in state of emergency decrees have applied to the European Court of Human Rights (ECHR) since Turkeys July 2016 coup attempt.
Oracle Corp ORCL.O said on Thursday it was moving its stock listing to the New York Stock Exchange from Nasdaq OMX Groups (NDAQ.O) main U.S. exchange, a major coup for NYSE Euronext NYX.N, as it lands the largest-ever U.S. market transfer.
Carpictures.cc is a service of Ontology2; © copyright 2008. Images on this site are licensed CC-BY or CC-BY-SA; Image descriptions and metadata are CC-BY-SA. Information from Freebase and Dbpedia have played a role in the construction of this site ...
A BOATBUILDER from Wales who has been blind for the past 38 years is set to dazzle visitors to this years Chelsea Flower Show with his latest creation.
2) Theres a mantra that I pulled from a book that Ive found to be somewhat useful. Aumala. Pronounce it in four syllables, Ahh (rhyming with Bach, oo rhyming with coup, mah rhyming with Todd, and lah rhyming with lock. Like all mantras, the more you use it the clearer sense youll get for it, but from what I gather...it seems to identify the self with all that is, and when youve filled yourself with that concept, whatever is trying to hurt you or eat you tends to feel the result of its own actions against you. However, I have also found that while this mantra can in some cases put a complete and instant halt to everything bad that is going on...is some other cases Ive found it to be utterly useless. My best guess is that if youre being attacked by a conscious being, it will be aware of whats going on, and stop as to avoid hurting itself. But, it seems to be fairly trivial for them to change methods and use non-conscious probes to do the work by proxy. So, in my experience, while ...
This barely released thriller, Any Mans Death, offers one dunderheaded miscasting coup after another. Waspy John Savage plays a Jewish…
... may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ... humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor ...
Consisting of about 110 amino acids, the domain in winged-helix transcription factors (see Regulation of gene expression) has ... Winged-Helix+Transcription+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Winged-helix_transcription_factors&oldid=730546101" ...
Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a ... Zinc finger transcription factor. From Wikipedia, the free encyclopedia. (Redirected from Zinc finger protein transcription ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ... Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single ...
"This is my coup story." A story in the Great Falls Tribune noted, "When the station was replaying programming that originated ... The transcription uses an official, technically accurate alphabet and the authors of this book have classified entries and ... According to the UNESCO Factor 9: Amount and Quality of Documentation, there may be adequate grammar or sufficient amount of ... According to the UNESCO Factor 1: Intergenerational Transmission, Blackfoot is classified under severely endangered. It is ...
第二亚族(COUP-TF(英语:Chicken ovalbumin upstream promoter-transcription factor)(I、II)、Ear-2(英语:V-erbA-related gene)、HNF4(英语: ... 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、4、5、6、7) · AP-1(c-Fos、 ... sequence-specific enhancer binding RNA polymerase II transcription factor activity. · transcription factor binding. · zinc ion ... GATA(英语:GATA transcription factor)(1、2、3、4、5、6) · MTA(1、2、3) · TRPS1(英语:Tricho-rhino-phalangeal syndrome Type
In 1799, Napoleon took over as head of the French government in the Coup of 18 Brumaire and declared the French Revolution over ... Ferling attributes Adams's defeat to five factors: the stronger organization of the Republicans; Federalist disunity; the ... "Declaration of Independence: A Transcription". United States National Archives. November 2015. Retrieved October 1, 2018. " ...
These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... The decline of the Hawaiian language was accelerated by the coup that overthrew the Hawaiian monarchy and dethroned the ... in making handwritten transcriptions of Hawaiian vowels.[86] The missionaries specifically requested their sponsor in Boston to ...
Handbook of Transcription Factor NF-κB. Boca Raton: CRC. 2006. ISBN 0-8493-2794-6.. ... 第二亚族(COUP-TF(I、II)、Ear-2、HNF4(α、γ)、PNR、RXR(α、β、γ)、Testicular receptor(2、4)、TLX). 第三亚族(甾类激素(英语:Steroid hormone receptor)(雄激素、雌激素 ... ELF(2、4、5) · EGF · ELK(1、3、4) · ERF · ERG · ETS(1、2、SPIB) · ETV(1、4、5、6) · FLI1 · Interferon regulatory factors(1、2、3、4、5、6、7、8 ... 核因子活化B细胞κ轻链增强子(英語:nuclear factor kappa-light-chain-enhancer of activated
repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. • ... activating transcription factor binding. Cellular component. • cytosol. • nucleoplasm. • protein complex. • nucleolus. • ... Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, ... transcription factor binding. • RNA polymerase II core promoter proximal region sequence-specific DNA binding. • E-box binding ...
It could have been a combination of both factors. In 1823, the Graz Music Society gave Schubert an honorary diploma. He felt ... Puech, Benjamin (2019-02-07). "La Symphonie n°8 de Schubert achevée à coups d'intelligence artificielle". Le Figaro.fr (in ... using the transcription of the first two movements prepared by Hüttenbrenner, his own completion of Schubert's Scherzo, and the ... Rosamunde entr'acte in a transcription by Friedrich Hermann, edited by Goldstone. The work in this completed version was given ...
Upon returning to England he was assigned to the Human factors Branch of Operations research at the War Office. In 1949, he was ... Although Cybersyn was abandoned after Allende was removed from power by the Pinochet coup in 1973, Beer continued to work in ... "Designing Freedom" The 1973 Massey Lectures RADIO CANADA INTERNATIONAL TRANSCRIPTION: E1121 "The Real Threat to all We Most ... but was interrupted by the 1973 coup d'état. The Viable System Model (VSM) is a model of the organisational structure of any ...
A sigma factorfactor) is a protein needed only for initiation of transcription.[1] It is a bacterial transcription ... Sigma factors in E. coli:. *σ70(RpoD) - σA - the "housekeeping" sigma factor or also called as primary sigma factor, ... It is homologous to archaeal transcription factor B and to eukaryotic TFIIB.[2] The specific sigma factor used to initiate ... The number of sigma factors varies between bacterial species.[1][4] E. coli has seven sigma factors. Sigma factors are ...
Transcription Factor Classification, A classification of transcription factors based on their DNA-binding domains". BIOBASE ... potfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). potfamilija 3 ( ... Latchman DS (1997). „Transcription factors: an overview". Int. J. Biochem. Cell Biol. 29 (12): 1305-12. PMID 9570129. doi: ... DBD: Transcription factor database Home". Приступљено 2. 3. 2008.. *. Wilson D, Charoensawan V, Kummerfeld SK, Teichmann SA ( ...
transcription factor activity, sequence-specific DNA binding. • RNA polymerase II transcription factor activity, sequence- ... "Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Hormone and ... transcription factor complex. • nucleolus. • cell nucleus. Biological process. • skeletal system development. • pituitary gland ... "Entrez Gene: PITX1 paired-like homeodomain transcription factor 1".. *^ Philippi A, Tores F, Carayol J, Rousseau F, Letexier M ...
transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ... transcription regulatory region DNA binding. Cellular component. • transcription factor complex. • protein complex. • nuclear ... In addition, this transcription factor plays an important role in limb and branchial arch development.[6] In one study, it was ... Shen L, Li XF, Shen AD, Wang Q, Liu CX, Guo YJ, Song ZJ, Li ZZ (July 2010). "Transcription factor HAND2 mutations in sporadic ...
M type MADS family at PlantTFDB: Plant Transcription Factor Database. *MIKC type MADS family at PlantTFDB: Plant Transcription ... Gramzow L, Ritz MS, Theissen G (April 2010). "On the origin of MADS-domain transcription factors". Trends in Genetics. 26 (4): ... Shore P, Sharrocks AD (April 1995). "The MADS-box family of transcription factors". European Journal of Biochemistry. 229 (1): ... the protein shows homology to transcription factors". The EMBO Journal. 9 (3): 605-13. PMC 551713 . PMID 1968830.. ...
transcription factor activity, sequence-specific DNA binding. • DNA binding. • transcription cofactor activity. • histone ... regulation of transcription from RNA polymerase II promoter. • regulation of transcription, DNA-templated. • transcription, DNA ... Dimberg J, Hugander A, Häll-Karlsson BM, Sirsjö A (Mar 2002). "RFX-B, a MHC class II transcription factor, suppressed in human ... The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex ...
RNA polymerase II transcription factor binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... negative regulation of sequence-specific DNA binding transcription factor activity. • regulation of transcription, DNA- ... negative regulation of transcription, DNA-templated. • transcription, DNA-templated. • negative regulation of transcription ... Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by ...
... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is ... "Entrez Gene: GATA1 GATA binding protein 1 (globin transcription factor 1)".. *^ a b c Da Costa L, O'Donohue MF, van Dooijeweert ... transcription factor complex. • protein-DNA complex. Biological process. • negative regulation of cell proliferation. • ...
transcription factor binding. • protein domain specific binding. • RNA polymerase II transcription factor activity, sequence- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... transcription factor activity, sequence-specific DNA binding. • transcription regulatory region DNA binding. • sequence- ... transcription, DNA-templated. • spermatogenesis. • positive regulation of transcription from RNA polymerase II promoter. • ...
transcription corepressor activity. • transcription factor activity, sequence-specific DNA binding. • transcription coactivator ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • nuclear euchromatin. • ... transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. • chenodeoxycholic acid binding. • ... RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. • bile acid receptor activity ...
transcription factor activity, RNA polymerase II transcription factor recruiting. • RNA polymerase II transcription factor ... Arabidospsis thaliana MYB family at Database of Arabidopsis Transcription Factors (DATF). This article incorporates text from ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ...
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... negative regulation of sequence-specific DNA binding transcription factor activity. • transcription, DNA-templated. • positive ...
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • protein kinase binding. • ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. Cellular component. • cytoplasm. • cell nucleus ... This transcription factor is most noted for its use in the interspecifically induced expression of ectopic eyes and is of ... As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system. The ...
transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence-specific DNA ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... regulation of transcription, DNA-templated. • negative regulation of transcription from RNA polymerase II promoter. • positive ... "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339-47. PMC ...
transcription factor activity, sequence-specific DNA binding. • sequence-specific DNA binding. • transcription factor binding. ... repressing transcription factor binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... transcription factor complex. • cytoplasm. • cell nucleus. • nucleoplasm. • transcriptional repressor complex. Biological ... RNA polymerase II repressing transcription factor binding. • protein binding. • recombinase activity. • chromatin binding. • ...
0001204 DNA-binding transcription factor activity. • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • regulation of transcription from RNA polymerase ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ... KLF17, ZNF393, Zfp393, Kruppel-like factor 17, Kruppel like factor 17, ZLF393. ...
... , ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.[5][6][7] The OSR1 and OSR2 ... OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd,[5] bowl, sob[9] and ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • RNA polymerase II regulatory region sequence- ...
... , MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1. ... transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... transcription, DNA-templated. • positive regulation of transcription, DNA-templated. • positive regulation of transcription ... Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[5][6] ...
The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... positive regulation of transcription from RNA polymerase II promoter. • transcription, DNA-templated. • transcription from RNA ... GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. ... regulation of transcription, DNA-templated. • organ induction. • anterior/posterior pattern specification. • ...
Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1-2): 1-14. PMID ... podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 ( ... a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor". ... Coller HA, Forman JJ, Legesse-Miller A (2007). ""Myc'ed Messages": Myc Induces Transcription of E2F1 while Inhibiting Its ...
... s (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... Sterol regulatory element-binding transcription factor 1. X-ray crystallography of Sterol Regulatory Element Binding Protein 1A ... The precursor has a hairpin orientation in the membrane, so that both the amino-terminal transcription factor domain and the ...
Gunkel, Christoph (September 13, 2013). "Öko-Coup aus Ostdeutschland". Der Spiegel (in German). Retrieved 4 September 2015.. ... Another factor that may prolong ozone depletion is the drawdown of nitrogen oxides from above the stratosphere due to changing ... resulting in transcription errors when the DNA replicates. These cancers are relatively mild and rarely fatal, although the ... due to a combination of political factors (continued resistance from the halocarbon industry and a general change in attitude ...
The officials who gained power by succeeding in the imperial examination became a leading factor in the shift from a military- ... out of fear that Emperor Gong would stage a coup to restore his reign.[58] Other members of the Song Imperial Family continued ... Transcriptions. Standard Mandarin. Hanyu Pinyin. Sòng cháo. Gwoyeu Romatzyh. Sonq chaur. Wade-Giles. Sung4 ch'ao2. ...
This unsettled the Kremlin, which orchestrated a coup carried out in 1929 by five young Tuvan graduates of Moscow's Communist ... Then, Tuva was administered as part of Outer Mongolia, and the language difference was a determining factor in Tuva seeking ...
Dardess, John W. (1968), Background Factors in the Rise of the Ming Dynasty, Columbia University.. ... On 7 August 1461, the Chinese general Cao Qin and his Ming troops of Mongol descent staged a coup against the Tianshun Emperor ... Transcriptions. Standard Mandarin. Hanyu Pinyin. Dà Míng Dì Guó. Wade-Giles. Ta Ming Ti Kuo. ... Robinson, David M. (1999), "Politics, Force and Ethnicity in Ming China: Mongols and the Abortive Coup of 1461", Harvard ...
"A phylogenomic analysis of bacterial helix-turn-helix transcription factors.". FEMS Microbiol Rev 33 (2): 411-29. PMID 19076237 ... podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX). podfamilija 3 ( ... "Prokaryotic transcription regulators: more than just the helix-turn-helix motif.". Curr Opin Struct Biol 12 (1): 98-106. PMID ...
transcription factor complex. • RNA polymerase II transcription factor complex. • Ядерце. • клітинне ядро. • nucleoplasm. • ... 0001204 DNA-binding transcription factor activity. • GO:0001105 transcription coactivator activity. • transcription factor ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... transcription from RNA polymerase II promoter. • cellular response to tumor necrosis factor. • positive regulation of DNA- ...
... s (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors.[2] Unactivated SREBPs are attached ... The precursor has a hairpin orientation in the membrane, so that both the amino-terminal transcription factor domain and the ... Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol- ...
0001201 DNA-binding transcription factor activity, RNA polymerase II-specific. • transcription factor activity, RNA polymerase ... RNA polymerase II transcription factor binding. • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription ... GO:0000975 transcription regulatory region DNA binding. • transcription factor activity, RNA polymerase II distal enhancer ... regulation of transcription, DNA-templated. • cellular response to BMP stimulus. • зсідання крові. • transcription, DNA- ...
transcription corepressor activity. • metal ion binding. • nucleic acid binding. • RNA polymerase II transcription factor ... DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. ... negative regulation of transcription from RNA polymerase II promoter. • negative regulation of intracellular estrogen receptor ... than normal breast tissue from the same patient and that DC-SCRIPT mRNA expression is an independent prognostic factor for good ...
see also transcription factor/coregulator deficiencies. This article on a gene on the human X chromosome and/or its associated ... regulation of transcription, DNA-templated. • transcription, DNA-templated. • DNA geometric change. • negative regulation of B ...
Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has ... "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP ...
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... Alternate Names for COUP-TF I/NR2F1 Antibody. *COUP transcription factor 1 ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ...
COUP-TFs) are members from. The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the ... The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ... The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from ... Also, we explain the series and id of another low Mr COUP-TF, COUP-TF2. Components and strategies Purification from the COUP- ...
Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either ... Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new ... COUP-TFI target gene in HeLa S3 cells. These results may underlie the complexity of COUP-TFI action in mammalian cells. ... Many of these proteins and COUP-TFI were demonstrated to co-occupy the promoter of retinoic acid-induced 1, a newly identified ...
... chicken ovalbumin upstream promoter transcription factor 1) in controlling the hippocampal, anatomical, and functional ... Genetic factors expressed in gradient during development seem to control the size and correct positioning of the HP along its ... Loss of cortical COUP-TFI function results in a dysmorphic HP with altered shape, volume, and connectivity, particularly in its ... Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis ...
"Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, OMalley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine ...
... upstream stimulatory factor-1/2 (USF-1/2), and chicken ovalbumin upstream promoter transcription factor-1/2 (COUP-TFI/II) ... Orphan Receptor Chicken Ovalbumin Upstream Promoter Transcription Factors Inhibit Steroid Factor-1, Upstream Stimulatory Factor ... "Orphan Receptor Chicken Ovalbumin Upstream Promoter Transcription Factors Inhibit Steroid Factor-1, Upstream Stimulatory Factor ... "Orphan Receptor Chicken Ovalbumin Upstream Promoter Transcription Factors Inhibit Steroid Factor-1, Upstream Stimulatory Factor ...
In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor ... A COUP-TF/Svp homolog is highly expressed during vitellogenesis in the mosquito Aedes aegypti ... It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. AaSvp transcripts and ... 2004 ). ER stability depends on many factors, such as post-translational modifications, interactions with other proteins (i.e. ...
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF ... a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro ...
COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ... humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor ...
GO:0003700 DNA-binding transcription factor activity GO:0003707 steroid hormone receptor activity GO:0004879 nuclear receptor ...
COUP transcription factor 1Imported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,Q32NY6,Q32NY6_MOUSE COUP transcription factor 1 OS=Mus musculus OX=10090 GN=Nr2f1 PE=1 SV=1 ... Transcription, Transcription regulationPROSITE-ProRule annotation. ,p>Information which has been generated by the UniProtKB ... positive regulation of transcription by RNA polymerase II Source: Ensembl. *transcription, DNA-templated Source: UniProtKB- ...
Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... COUP transcription factor 2Add BLAST. 414. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... sp,P43135,COT2_MOUSE COUP transcription factor 2 OS=Mus musculus OX=10090 GN=Nr2f2 PE=1 SV=2 ...
COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a ... COUP Transcription Factors. Subscribe to New Research on COUP Transcription Factors A sub-family of steroid receptor-related ... COUP TF Proteins; Chicken Ovalbumin Upstream Promoter Transcription Factors; Transcription Factors, COUP ...
Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical ... The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and ... Romano, Anna Lisa (2013) Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis ... Next, by generating double compound mutants between COUP-TFI and Pax6, I found that lowering the gene dosage of Pax6 in COUP- ...
NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Product Name:Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Packing: ... Target Protein Name:Bovine COUP transcription factor 2, NR2F2 Alternative Name:NR2F2,Bovine COUP transcription factor 2, NR2F2 ... The microtiter plate provided in Bovine COUP transcription factor 2, NR2F2 ELISA KIT has been pre-coated with an Bovine COUP ...
Rabbit recombinant monoclonal COUP TF1 antibody [EPR10841] conjugated to Alexa Fluor® 647. Validated in ICC/IF and tested in ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... Alexa Fluor® 555 Anti-COUP TF1 antibody [EPR10841] (ab211712) *Anti-COUP TF1 antibody [EPR10841] - BSA and Azide free (ab224272 ... Alexa Fluor® 647 Anti-COUP TF1 antibody [EPR10841]. See all COUP TF1 primary antibodies. ...
Rabbit recombinant monoclonal COUP TF1 antibody [EPR10841] conjugated to Alexa Fluor® 488. Validated in ICC/IF and tested in ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 647) (ab210038) *Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 555) (ab211712 ... Anti-COUP TF1 antibody [EPR10841] (Alexa Fluor® 488). See all COUP TF1 primary antibodies. ...
Mechanism of Action of COUP-Transcription Factors Tsai, Ming-Jer Baylor College of Medicine, Houston, TX, United States ... We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult ... When COUP-TFII is conditionally ablated early, the MM cannot form properly and no kidney is formed. When COUP-TFII is knocked ... The various COUP-TFII deficient mouse models generated here will reveal how COUP-TFII affects kidney development and disease ...
Dividing COUP-TFII+ progenitor cells were localised to ventral CGE as previously described but were also numerous in adjacent ... Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 ... We examined expression of three interneuron precursor transcription factors, alongside other markers, using ... Thus COUP-TFII+ progenitors gave rise to pyramidal cells, but also interneurons which not only migrated posteriorly into the ...
Wang, L. H., Tsai, S. Y., Cook, R. G., Beattie, W. G., Tsai, M. J. and OMalley, B. W. (1989). COUP transcription factor is a ... C) Expression of COUP-TFI and COUP-TFII transcripts in cochleae treated with DAPT. COUP-TFI and COUP-TFII expression was not ... Expression of COUP-TFI and COUP-TFII are unchanged by DAPT treatment. We next determined whether DAPT treatment affected COUP- ... COUP-TFI (chicken ovalbumin upstream promoter transcription factor I; also known as NR2F1) is an ONR proposed to function as a ...
Transcription factor NR2F2 (also known as chicken ovalbumin upstream promoter transcription factor II, COUP-TFII) plays a key ... 1997). Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr. Rev. 18, 229-240. doi:10.1210 ... 2005). Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435, 98-104. doi: ... 2011). Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. ...
The nuclear receptor chicken ovalbumin upstream promoter-transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult ... COUP-TFII regulates mouse Amhr2 gene transcription in MA-10 Leydig cells. (A) Depletion of COUP-TFII in MA-10 Leydig cells ... 1 transcription factor. COUP-TFII transcriptionally cooperates with SP1 on the Amhr2 promoter. Mutations that altered the ... supporting an additional role in steroidogenesis for this transcription factor. COUP-TFII action in Leydig cells remains to be ...
COUP /EAR ,/li,,/ul,,ul,,ul,,li,1: Chicken ovalbumin upstream promoter-transcription factor I ( COUP-TFI ; NR2F1 ) ,/li,,/ul,,/ ... ul,,ul,,ul,,li,2: Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li, ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ...
Browse our COUP-TF I/NR2F1 product catalog backed by our Guarantee+. ... COUP-TF I/NR2F1 products available through Novus Biologicals. ... transcription factor, binds to the ovalbumin promoter and, in ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ... PTMs for COUP-TF I/NR2F1. Learn more about PTMs related to COUP-TF I/NR2F1.. Phosphorylation. Oxidation. Dephosphorylation. ...
The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ...
Working in mice, Zhao et al. discovered that this process instead was actively promoted by the transcription factor COUP-TFII ( ... Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) ... A transcription factor drives the process by which female mouse embryos establish their sex-specific reproductive structures. ... A transcription factor drives the process by which female mouse embryos establish their sex-specific reproductive structures. ...
Transcription factor COUP. ENSMUSP00000034831. ProSitePatterns. PS00031. IPR001628. 40. 66. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 381. 392. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 361. 374. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 314. 326. 1.20e-14. ...
Transcription factor COUP. ENSSARP00000012244. ProSitePatterns. PS00031. IPR001628. 46. 72. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSSARP00000012244. PRINTS. PR01282. IPR003068. 390. 401. 5.10e-05. ... Transcription factor COUP. ENSSARP00000012244. PRINTS. PR01282. IPR003068. 370. 383. 5.10e-05. ... Copyright © 2017 REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies ...
Top Transcription factor binding sites by QIAGEN in the TAOK2 gene promoter:. *COUP ... No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAOK2 Gene ... Transcription Factor. Binding Sites. Gene Targets. GH16J029972. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE CraniofacialAtlas ...
Top Transcription factor binding sites by QIAGEN in the MYL7 gene promoter:. *COUP ... Transcription Factor Targets and HOMER Transcription for MYL7 Gene Localization for MYL7 Gene Jump to section. Aliases. ... Transcription Factor. Binding Sites. Gene Targets. GH07J044146. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE CraniofacialAtlas ...
COUP Transcription Factor II * DNA-Binding Proteins * LIM Domain Proteins * MEF2 Transcription Factors ... CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. Although recent studies ... aka COUP-TFII), generating a premature truncation of the protein. This patient also carried a missense variant predicted to be ...
IPR003068 Transcription factor COUP. IPR013088 Zinc finger, NHR/GATA-type. IPR001628 Zinc finger, nuclear hormone receptor-type ...
Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. . Keio J. Med. 52, 174-181 ( ... A series of transcription factors critical for maintenance of the neural stem cell state have been identified1,2,3, but the ... exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. . Cell ... Combinatorial roles of the nuclear receptor corepressor in transcription and development. . Cell 102, 753-763 (2000) ...
... yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress ... COUP Transcription Factor I / metabolism * Cholesterol / metabolism * Cytoprotection* / radiation effects * Fatty Acids / ... Among the nuclear orphan receptors affected by insufficiency of RANBP2, we identified an isoform of COUP-TFI (Nr2f1) as the ... yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress ...
... chicken OVA upstream promoter-transcription factor 1; HNF-4α, hepatocyte nuclear factor-4α; SHBG, sex hormone-binding globulin ... We have also demonstrated that competition between HNF-4α and COUP-TF1 occurs at this site, with HNF-4α promoting transcription ... Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter. J. Biol. ... Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors. J. ...
COUP-TF. Chicken ovalbumin upstream promoter transcription factor. mCPT I. Muscle carnitine palmitoyl transferase I ... Akazawa H, Komuro I (2003) Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res 92:1079-1088PubMedGoogle ... Sack MN, Disch DL, Rockman HA, Kelly DP (1997) A role for Sp and nuclear receptor transcription factors in a cardiac ... Oka T, Xu J, Molkentin JD (2007) Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev ...
  • Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. (novusbio.com)
  • Western Blot: COUP-TF I/NR2F1 Antibody [NBP2-15974] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. (novusbio.com)
  • Gel mobility shift and antibody supershift assays demonstrated that nuclear factors c-Fos/c-Jun, steroidogenic factor-1 (SF-1), upstream stimulatory factor-1/2 (USF-1/2), and chicken ovalbumin upstream promoter transcription factor-1/2 (COUP-TFI/II) potentially bound to RE-3. (bioone.org)
  • Here, we challenge the in vivo function of the nuclear receptor COUP-TFI (chicken ovalbumin upstream promoter transcription factor 1) in controlling the hippocampal, anatomical, and functional properties along its longitudinal axis. (ovid.com)
  • In Drosophila, Svp, a homolog of chicken ovalbumin upstream promoter transcription factor (COUP-TF), inhibits ecdysone receptor complex-mediated transactivation in vitro and in vivo. (bioscientifica.com)
  • We have also extended our previous observations by showing that a sequence containing an E-box was not only bound by USF proteins but also recognized by COUP-TF orphan receptors. (bioone.org)
  • Little is known regarding how the regulatory factors balance expression of this gene in ovarian cycles or spermatogenic stages. (bioone.org)
  • Recombinant protein encompassing a sequence within the center region of human COUP TF1. (novusbio.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • It possesses a high degree of amino acid sequence similarity to the members of the COUP-TF/Svp subfamily. (bioscientifica.com)
  • Functional studies demonstrated that USF-1/2, c-Fos/c-Jun, and SF-1 were activators, whereas COUP-TFs were repressors. (bioone.org)
  • Loss of cortical COUP-TFI function results in a dysmorphic HP with altered shape, volume, and connectivity, particularly in its dorsal and intermediate regions. (ovid.com)
  • COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein that in humans is encoded by the NR2F2 gene This disambiguation page lists articles associated with the title COUP transcription factor. (wikipedia.org)
  • Product Description:Bovine COUP transcription factor 2, NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. (lifescience-market.com)
  • Only those wells that contain Bovine COUP transcription factor 2, NR2F2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (lifescience-market.com)
  • The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm.The concentration of Bovine COUP transcription factor 2, NR2F2 in the samples is then determined by comparing the O.D. of the samples to the standard curve. (lifescience-market.com)
  • In the present study, we demonstrate that NR2F2 differentially regulates gene expression of venous versus lymphatic ECs (LECs) and document a novel paradigm whereby NR2F2 homodimers induce a venous EC fate, while heterodimers with the LEC-specific transcription factor PROX1 instruct LEC lineage specification. (biologists.org)
  • The nuclear receptor chicken ovalbumin upstream promoter-transcription factor type II (COUP-TFII)/NR2F2 is expressed in adult Leydig cells, and conditional deletion of the Coup-tfii / Nr2f2 gene impedes their differentiation. (nih.gov)
  • Although the majority of these genes are not known to be associated with CDH, one patient with CDH and cardiac anomalies harbored a frameshift mutation in NR2F2 (aka COUP-TFII), generating a premature truncation of the protein. (nih.gov)
  • NR2F2 / COUP2 (ARP1, TFCOUP2, COT2, COUP-TF2) is a member of the nuclear receptor superfamily related to the COUP transcription factor. (activemotif.com)
  • The goals of the existing work were Procyanidin B3 inhibitor to spell it out the proteins that bind towards the COUP response component to create the slower (C2) EMSA complicated, and to discover new members from the COUP-TF family members and determine their function. (biodiversityhotspot.org)
  • A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. (aacrjournals.org)
  • Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. (aacrjournals.org)
  • Collectively, our TAP strategy revealed that COUP-TFI may associate with a number of transcriptional regulatory proteins in HeLa S3 cells as well as other classes of proteins that have not been previously implicated in the regulation of gene expression. (aacrjournals.org)
  • Many of these proteins and COUP-TFI were demonstrated to co-occupy the promoter of retinoic acid-induced 1, a newly identified, COUP-TFI target gene in HeLa S3 cells. (aacrjournals.org)
  • We identified interactions between the cortical hem, rich in Wingless-Int (WNT) proteins and bone morphogenetic proteins (BMPs), and an anterior telencephalic source of fibroblast growth factors (FGFs). (biologists.org)
  • 2004) Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. (prolekare.cz)
  • It interacts with several nuclear receptor co-activator proteins to activate transcription. (activemotif.com)
  • 1995). Deletion analysis of the mouse BMP4 promoter in MC3T3E1 cells identified a cis-acting E-box element proximal to the transcriptional start site that is bound by upstream regulatory factor ( USF ), a member of the helix-loop-helix family of regulatory proteins (Ebara et al. (atlasgeneticsoncology.org)
  • In Drosophila , two decades of work have revealed a network of sequentially expressed transcription factors and RNA-binding proteins that compose a neural progenitor-intrinsic temporal patterning system. (biologists.org)
  • Remember, transcription factors can interact with hundreds of different binding sites to regulate hundreds of different proteins. (blogspot.com)
  • The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells. (nih.gov)
  • Consistent with this, COUP-TFII directly activates a -1486 bp fragment of the mouse Amhr2 promoter in transient transfection assays. (nih.gov)
  • Chromatin immunoprecipitation assay confirmed COUP-TFII recruitment to the proximal Amhr2 promoter whereas DNA precipitation assay revealed that COUP-TFII associates with the -67/-34 bp region in vitro . (nih.gov)
  • COUP-TFII transcriptionally cooperates with SP1 on the Amhr2 promoter. (nih.gov)
  • Mutations that altered the GCGGGGCGG sequence at -39 bp abolished COUP-TFII-mediated activation, COUP-TFII/SP1 cooperation, and reduced COUP-TFII binding to the proximal Amhr2 promoter. (nih.gov)
  • Our data provide a better understanding of the mechanism of COUP-TFII action in Leydig cells through the identification and regulation of the Amhr2 promoter as a novel target. (nih.gov)
  • B) COUP-TFII activates the mouse Amhr2 promoter in MA-10 Leydig cells. (nih.gov)
  • MA-10 Leydig cells were cotransfected with either 100 ng of an empty expression vector (control, open bars) or an expression vector for COUP-TFII (filled bars), along with 400 ng of Amhr2 promoter construct (−1486/+77 bp or −34/+77 bp, as indicated). (nih.gov)
  • The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. (biodiversityhotspot.org)
  • 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al. (biodiversityhotspot.org)
  • Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. (sciencemag.org)
  • This occurred via a downregulation of hepatocyte nuclear factor-4α (HNF-4α) and replacement of HNF-4α by the chicken OVA upstream promoter-transcription factor 1 at a cis -element within the human SHBG promoter, coincident with repression of its transcriptional activity. (jci.org)
  • Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. (aacrjournals.org)
  • Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. (jci.org)
  • Here we show that unc-55 encodes a member of the nuclear hormone receptor gene family that is similar to the vertebrate chicken ovalbumin upstream promoter transcription factors. (jneurosci.org)
  • A gene on chromosome 5q14 that encodes a transcription factor that binds to the ovalbumin promoter and, in conjunction with S300-II, stimulates initiation of transcription. (thefreedictionary.com)
  • Here, we challenge the in vivo function of the nuclear receptor COUP-TFI (chicken ovalbumin upstream promoter transcription factor 1) in controlling the hippocampal, anatomical, and functional properties along its longitudinal axis. (ovid.com)
  • Chicken ovalbumin upstream promoter-transcription factor (COUP-TF), DAX-1, and steroidogenic factor-1 (SF-1) are orphan members of the nuclear hormone receptor superfamily. (elsevier.com)
  • As a prototype for our analysis, we investigated the expression patterns of chicken ovalbumin upstream promoter transcription factor (COUP-TF) -I and -II in more details during embryonic development and in the adult by immunohistochemistry. (nih.gov)
  • Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. (elsevier.com)
  • The receptor transactivation domain is responsible for interaction at the promoter with co-activators such as acetyltransferases and the general transcription machinery, resulting in transcriptional activation. (cellsignal.com)
  • Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. (zfin.org)
  • 1996). Mouse BMP4 is negatively regulated by direct binding of chicken ovalbumin upstream-transcription factor I (COUP-TF1) to the proximal promoter of exon I (Feng et al. (atlasgeneticsoncology.org)
  • Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. (aacrjournals.org)
  • It was reported that nuclear receptors COUP-TFII and TR4 are recruited to the enriched GGGTCA variant repeats embedded within ALT telomeres, implicating nuclear receptors in regulating ALT activity. (sciencemag.org)
  • Transcription factors 3: nuclear receptors. (embl.de)
  • In addition to COUP-TFs, we also examined the expression profiles of eight other nuclear receptors (farnesoid X receptor, vitamin D receptor, hepatocyte nuclear factor 4alpha, retinoid X receptor alpha, mineralocorticoid receptor, steroidogenic factor 1, liver receptor homolog-1, and germ cell nuclear factor). (nih.gov)
  • Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. (wikipathways.org)
  • The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ovalbumin gene (Sagami et al. (biodiversityhotspot.org)
  • Competition oligonucleotides included the ovalbumin COUP series (C70 to C90) or a mutant series, with two bottom adjustments that abolish COUP-TF binding (Wang et al. (biodiversityhotspot.org)
  • Western Blot: COUP-TF I/NR2F1 Antibody [NBP2-15974] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. (novusbio.com)
  • Antibody specifically recognices human COUP-TF I and cross reacts with mouse and rat COUP-TF I. This antibody does not recognices human COUP-TF II and EAR2. (peptanova.de)
  • Because loss-of-function studies of Notch signaling components have similar phenotypes, we investigated Notch regulation of hair cell differentiation in COUP-TFI -/- mice and confirmed misregulation of Notch signaling components, including Jag1, Hes5 and in a manner consistent with reduced Notch signaling, and correlated with increases in hair cell and support cell differentiation. (biologists.org)
  • Importantly, inhibition of Notch activity resulted in a greater increase in hair cell differentiation in COUP-TFI -/- cochlear cultures than in wild-type cultures, suggesting a hypersensitivity to Notch inactivation in COUP-TFI -/- cochlea, particularly at the apical turn. (biologists.org)
  • Thus, we present evidence that reduced Notch signaling contributes to increases in hair cell and support cell differentiation in COUP-TFI -/- mice, and suggest that COUP-TFI is required for Notch regulation of hair cell and support cell differentiation. (biologists.org)
  • The formidable challenge of unravelling the molecular complexity of AEC, VEC and LEC differentiation is further enhanced by the notion that several factors are commonly expressed amongst EC subtypes. (biologists.org)
  • In the present work, we report that COUP-TFII is an essential regulator of the gene encoding the anti-Müllerian hormone receptor type 2 ( Amhr2 ), which participates in Leydig cell differentiation and steroidogenesis. (nih.gov)
  • GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. (ucsf.edu)
  • We find that the transcription factor Ctip2 (also known as Bcl11b ) is central to MSN differentiation and striatal development. (jneurosci.org)
  • In contrast, less is known about the transcription factor codes that regulate MSN differentiation and patch-matrix development after the progenitor stage. (jneurosci.org)
  • Bagheri-Yarmand R , Vadlamudi RK, Kumar R. Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. (thyroid.org)
  • Thus, during brain formation, the regulation of cell number and the precise timing of differentiation require the interplay between intrinsic programs of development and extrinsic factors. (frontiersin.org)
  • Endothelial cell differentiation depends on communication between the surrounding tissues, which is mediated by growth and differentiation factors able to activate specific gene expression programs. (ahajournals.org)
  • This further level of endothelial cell specialization is induced by the crosstalk with the cells of the surrounding tissues that produce growth and differentiation factors able to activate specific gene expression programs in endothelial cells (see Figure 1 ). (ahajournals.org)
  • All of these steps of endothelial differentiation are regulated by sets of transcription factors, which, in the figure, are listed in boxes corresponding to specific types of vessels. (ahajournals.org)
  • All the steps of endothelial cell differentiation are orchestrated by specific transcription factors ( Figure 1 ). (ahajournals.org)
  • However, very little is known about the transcription factors that induce organ-specific differentiation of the endothelium. (ahajournals.org)
  • This subset secretes key anti-inflammatory cytokines, notably TGFβ and IL-10, and Treg differentiation is driven by the transcription factor Foxp3. (frontiersin.org)
  • For instance, Foxg1 is required constitutively to repress the Cajal-Retzius fate in deep-layer neurons ( 10 ), and COUP-TF1 and Tbr1 are each required for subplate neuron differentiation ( 11 ). (pnas.org)
  • Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
  • TRA16 overexpression was significantly associated with TNM stage, tumor size, lymph node metastasis, tumor thrombus in vein, tumor differentiation and prognosis of NSCLC patients, in which TRA16 was shown to be an independent prognostic factor. (spandidos-publications.com)
  • In the differentiation of neurons and glia in the developing Drosophila eye, we found that the proper intensity of RTK signaling downstream of fibroblast growth factor receptor (FGFR) or epidermal growth factor receptor required two mutually antagonistic feedback loops. (sciencemag.org)
  • rs143383 is a C to T transition SNP located in the 5′untranslated region (5′UTR) of the growth differentiation factor 5 gene GDF5 . (prolekare.cz)
  • Several transcription factors have been shown to regulate the development of patch and/or matrix neurons by acting on the progenitors of MSN. (jneurosci.org)
  • Most of these receptors regulate transcription by binding to their target DNA elements either as monomers or homodimers and recruiting chromatin modifying coactivators and the transcription machinery. (cellsignal.com)
  • Nur77 and NURR1 can also heterodimerize with RXRs and these heterodimers are able to respond to RXR ligands to regulate transcription. (cellsignal.com)
  • 1996), whereas organizer signals, chordin and noggin, and X-lim1 negatively regulate BMP4 transcription (Kim et al. (atlasgeneticsoncology.org)
  • 1997). In mouse development, GATA-4 and - GATA-6 were found to specifically regulate BMP4 transcription to mediate endoderm-mesoderm signalling and early vasculogenesis (Nemer et al. (atlasgeneticsoncology.org)
  • 2008). Furthermore, the transcription factor Cdx2 has been shown to directly regulate BMP4 expression in mouse trophoblast cells to promote early mouse embryogenesis (Murohashi et al. (atlasgeneticsoncology.org)
  • 2011). In hepatocellular carcinoma cells, Ets-1 was demonstrated to directly regulate hypoxia-induced BMP4 transcription to promote tumorigenesis (Maegdefrau et al. (atlasgeneticsoncology.org)
  • Notch, COUP-TFII, and Prox1), While some factors specifically regulate lymphatic (Prox1), vein (COUP-TFII), or artery formation (Hey1/2), other vascular signaling pathways show overlapping activities (e.g. (biomedcentral.com)
  • The aim of this study was to identify trans -acting factors that bind to rs143383 and which regulate this GDF5 DAE. (prolekare.cz)
  • Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. (hindawi.com)
  • The nuclear receptor superfamily are ligand-activated transcription factors that play diverse roles in cell di erentiation/development, proliferation, and metabolism and are associated with numerous pathologies such as cancer, cardiovascular disease, infl ammation, and reproductive abnormalities. (cellsignal.com)
  • We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult organ function, plays a role in kidney development, function and disease. (grantome.com)
  • The orphan nuclear receptor COUP-TFI (Nr2f1) regulates many aspects of mammalian development, but little is known about its role in cochlear hair cell and Deiter's support cell development. (biologists.org)
  • COUP-TFII regulates mouse Amhr2 gene transcription in MA-10 Leydig cells. (nih.gov)
  • Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
  • Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
  • ERK5 regulates muscle cell fusion through Klf transcription factors. (semanticscholar.org)
  • Thus, our findings reveal that COUP-TFII/TR4 regulates ALT telomere maintenance through a novel noncanonical FANCD2 pathway. (sciencemag.org)
  • Here we review recent advances in understanding how glucose regulates gene transcription in mammals. (physiology.org)
  • Among the nuclear orphan receptors affected by insufficiency of RANBP2, we identified an isoform of COUP-TFI (Nr2f1) as the only receptor stably co-associating in vivo with RANBP2 and distinct isoforms of UBC9. (nih.gov)
  • COUP-TFI is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. (nursa.org)
  • In summary, the results indicate that co-localization of COUP-TF, DAX-1, and SF-1 in NL was lost in adrenocortical tumors and that these orphan receptors play an important role in the regulation of steroidogenesis in human adrenals. (elsevier.com)
  • To further define the defects of COUP-TFII mutants and dissect the underlying mechanism of COUP-TFII action, our specific aims in the next five years are: 1) Delineate the role of COUP-TFII in kidney development and its underlying mechanism;2) Determine the role of COUP-TFII in kidney function and diseases;and 3) Determine the role of COUP-TFII in diabetic nephropathy. (grantome.com)
  • Both CD4 + and CD8 + T cells exist as a number of subsets that perform unique functions within the immune milieu and exhibit unique surface receptors, produce lineage-specific cytokines, and express lineage-defining transcription factors. (frontiersin.org)
  • T reg cell transcriptional program is dependent on the transcription factor (TF) Foxp3, which is also essential for their development and suppression function ( 1 - 3 ). (sciencemag.org)
  • By analysing the vein-to-artery cell fate switch at single-cell resolution, they reveal two unexpected features: first, that the vein-to-artery conversion is gradual and overlapping until a transcriptional threshold is reached forming pre-specified artery cells and second, that this arterial pre-specification threshold is actively inhibited by cell cycle activation induced by the vein-specifying transcription factor COUP-TF2. (natureasia.com)
  • Transcription factor predominantly involved in transcriptional repression. (antikoerper-online.de)
  • In the first part of my work, I found that in the absence of COUP-TFI function cortical cells abnormally proliferate over time, implying that COUP-TFI is responsible for maintaining a proper progenitor pool during development. (unina.it)
  • Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. (ncl.ac.uk)
  • in both cases COUP-TFII was co-expressed with PAX6 in proliferative zones and TBR1 or calretinin in post-mitotic cortical neurons. (ncl.ac.uk)
  • Loss of cortical COUP-TFI function results in a dysmorphic HP with altered shape, volume, and connectivity, particularly in its dorsal and intermediate regions. (ovid.com)
  • The factor, COUP-TF1, ensures that the frontal areas dont claim too much cortical real estate. (bio-medicine.org)
  • So OLeary and his team collaborated with Italian researchers, led by Dr. Michele Studer, who is co-senior author with OLeary of the study, to develop mice in which COUP-TF1 can be selectively removed from progenitor cells in the cortex just before they start generating cortical neurons. (bio-medicine.org)
  • Regulation of the apolipoprotein A-I gene transcription. (uniprot.org)
  • Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. (jci.org)
  • The orchestration of these processes for different cell types requires the tight regulation of both intrinsic and extrinsic factors. (frontiersin.org)
  • Bolte C, Ren X, Tomley T et al (2015) Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development. (springer.com)
  • see below), an important transcription factor in the regulation of the fatty acid synthase ( FAS ) gene, is independent of external glucose. (physiology.org)
  • Oxidative stress is a deleterious stressor associated with a plethora of disease and aging manifestations, including neurodegenerative disorders, yet very few factors and mechanisms promoting the neuroprotection of photoreceptor and other neurons against oxidative stress are known. (nih.gov)
  • Generation of pure GABAergic neurons by transcription factor programming. (ucsf.edu)
  • In previous studies, the OLeary lab discovered that Emx2, a gene common to mice and men as is COUP-TF1, instructs progenitor cells to develop into visual neurons. (bio-medicine.org)
  • While Emx2 works in a positive manner to specify the area identity of visual neurons, the presence of COUP-TF1 prevents progenitor cells from taking on a motor area identity. (bio-medicine.org)
  • Most strikingly, Ctip2 , a transcription factor required for the formation of the corticospinal tract, was not expressed in the Fezl -deficient cortex. (pnas.org)
  • In addition, the repressor COUP-TF becomes strongly bound to a different recognition site on the class I enhancer, where it associates with a histone deacetylase (HDAC) and E1A-12, resulting in chromatin compaction. (upenn.edu)
  • Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). (jove.com)
  • In addition, a variety of transcription factor families acting downstream of-or in concert with-these signaling networks play vital roles in arteriovenous (AV) specification. (edu.au)
  • However, unlike deletion of Foxp3, lack of such transcription factors has not led to systemic lymphoproliferative diseases, but rather to more specific pathologies. (rupress.org)
  • Regulatory T (T reg ) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. (sciencemag.org)
  • After arterial and venous endothelial cells differentiate, a subpopulation of venous endothelial cells is thought to become competent to acquire lymphatic endothelial cell fate by progressively expressing the transcription factors Sox18 and Prox1 to differentiate into lymphatic endothelial cells. (edu.au)
  • Furthermore, adult mice with the loss of one COUP-TFII allele display polycystic kidneys, glomerulosclerosis (FSGS) and loss of kidney function, phenotypes resembling human kidney diseases. (grantome.com)
  • Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. (jci.org)
  • COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. (jci.org)
  • Abnormal signaling centers were further investigated in mice lacking the transcription factor EMX2, in which FGF8 activity is increased, WNT expression reduced, and the hippocampus defective. (biologists.org)
  • Completely eliminating the gene in lab mice through genetic engineering a mainstay of scientists trying to figure out the function of a particular gene did not clarify the roles of COUP-TF1. (bio-medicine.org)
  • Mice without COUP-TF1 have many defects and die a few days after birth before functional areas can be defined, explains co-first author Shen-Ju Chou, a postdoctoral researcher in the OLeary lab. (bio-medicine.org)
  • Although the mice lacking COUP-TF1 in their cortex do not have any obvious sensory or motor problems, the researchers believe that a closer look will reveal substantial deficits. (bio-medicine.org)
  • These include the Hedgehog, Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-β (TGF-β), Wnt and Notch signaling pathways. (edu.au)
  • These include Notch and Notch-regulated transcription factors (e.g. (edu.au)
  • Aitola M, Carlsson P, Mahlapuu M, Enerback S, Pelto-Huikko M (2000) Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions. (springer.com)
  • 1989). Therefore, COUPTF1, defined as a transcription aspect originally, Procyanidin B3 inhibitor joined up with the steroid/thyroid hormone receptor superfamily. (biodiversityhotspot.org)
  • Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and O'Malley BW (1989) COUP transcription factor is a member of the steroid receptor superfamily. (nursa.org)
  • 16. Moon NS, Di Stefano L, Dyson N (2006) A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. (prolekare.cz)
  • Genomic footprinting analysis shows that the glucocorticoid receptor uses local DNA demethylation as one of several steps to recruit transcription factors in hepatoma cells. (embopress.org)
  • In addition to ligand binding, nuclear receptor activity can be modulated through the action of numerous growth factor and cytokine signaling cascades that result in receptor phosphorylation or other post-translational modifi cations, typically within the N-terminal transactivation domain. (cellsignal.com)
  • Prior to ligand binding, receptor heterodimers are located in the nucleus as part of complexes with histone deacetylases (HDACs) and other co-repressors that keep target DNA in a tightly wound conforma- tion, preventing exposure to transacting factors. (cellsignal.com)
  • C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12). (dovepress.com)
  • TCF21 (zeige TCF21 Antikörper ) modulates Steroidogenic factor-1 and estrogen receptor beta (zeige ESR2 Antikörper ) expression through the recruitment of USF2 (zeige USF2 Antikörper ) in endometriotic stromal cells. (antikoerper-online.de)
  • The proximal part of the S-shaped body that will become the glomerulus after endothelial cell migration shows COUP-TFII expression in podocyte precursor cells and epithelial cells of the Bowman's capsule. (nih.gov)
  • In addition, excess proliferation in the COUP-TFI -/- sensory epithelium indicates that the origin of the extra HCs in the apex is complex. (biologists.org)
  • Dietary omega (n)-3, n-6 or n-9 fatty acids can variably alter (i.e. increase or decrease) the production of ILs (interleukins) and TNF (tumour necrosis factor) as well as the activity (e.g. phagocytosis) and proliferation of leukocytes (e.g. (biomedcentral.com)
  • Disruption of the cell cycle required the ability of AML-1-ETO to repress transcription because a mutant of AML-1-ETO, Δ469, which removes the majority of the corepressor binding sites, had no phenotype. (asm.org)
  • Furthermore, the COUP-TFII/TR4-mediated ALT telomere pathway does not require the FA core complex or the monoubiquitylation of FANCD2, key steps in the canonical FA pathway. (sciencemag.org)
  • 4. Dimova DK, Stevaux O, Frolov MV, Dyson NJ (2003) Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. (prolekare.cz)
  • Moreover, recent studies demonstrated mutual inhibition between PXR and nuclear factor (NF)-κB signaling pathway, providing a potential molecular mechanism that links xenobiotic metabolism and inflammation [ 10 , 11 ]. (mdpi.com)
  • Through the characterization of COUP-TF, the heterogeneity from the substances became obvious. (biodiversityhotspot.org)
  • At the nephrongenesis stage (E13.5), COUP-TFII becomes regionalized with high expression in the distal tubules and the glomeruli (podocytes and Bowman's capsule), but not detected in the proximal tubules. (grantome.com)
  • We examined expression of three interneuron precursor transcription factors, alongside other markers, using immunohistochemistry on 8-12 post-conceptional weeks (PCW) human telencephalon sections. (ncl.ac.uk)
  • NKX2.1, OLIG2 and COUP-TFII expression occupied distinct (although overlapping) neurogenic domains which extended into the cortex and revealed three CGE compartments: lateral, medial and ventral. (ncl.ac.uk)
  • A) Depletion of COUP-TFII in MA-10 Leydig cells reduces Amhr2 gene expression. (nih.gov)
  • We therefore examined the expression levels and immunolocalization of COUP-TF, DAX-1, and SF-1 in human adrenal gland (NL) and adrenocortical adenomas, and compared the results with CYP17 expression levels and its enzyme activities to study their potential correlation with adrenocortical steroidogenesis. (elsevier.com)
  • These results showed CYP17 expression to be upregulated and downregulated in CS and DOC, respectively, in a manner reciprocal to that of its repressors, COUP-TF and/or DAX-1. (elsevier.com)
  • We showed that COUP-TFI is expressed in the stroma and mesenchymal cells at embryonic d 11.5 (E11.5) and expression persists throughout embryonic development. (nih.gov)
  • In the adult kidney, only mesangial cells show meaningful COUP-TFI expression. (nih.gov)
  • In contrast, COUP-TFII expression is detected as early as E9.5 and high expression is seen in the mesenchymal-derived epithelial cells but not in the ureteric buds through E12.5. (nih.gov)
  • At E13.5, COUP-TFII expression becomes regionalized with higher expression in the region that gives rise to the distal tubule. (nih.gov)
  • Here, we identify that retinoic acid (RA) signaling directly promotes the expression of the transcription factor Nr2f1a within the anterior lateral plate mesoderm. (zfin.org)
  • BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. (elsevier.com)
  • Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. (elsevier.com)
  • Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development. (elsevier.com)
  • Further, the expression of sprouty was repressed and that of rau was increased by the COUP transcription factor Seven-up in the presence of weak, but not constitutive, activation of FGFR. (sciencemag.org)
  • Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV (2011) Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. (springer.com)
  • 2010). In retinal pigment epithelium cells of patients suffering from the wet form, but not the dry form, of macular degeneration, TNFalpha represses BMP4 transcription through phosphorylation of the transcription factor Sp1, demonstrating a BMP4 expression-dependent molecular switch (Xu et al. (atlasgeneticsoncology.org)
  • Knockdown and over expression of the factors demonstrated that Sp1, Sp3, and DEAF-1 are repressors of GDF5 expression. (prolekare.cz)
  • In conclusion, we have identified four trans -acting factors that are binding to GDF5 , three of which are modulating GDF5 expression via the OA susceptibility locus rs143383. (prolekare.cz)
  • CDH is considered to be a multifactorial disease, with strong evidence implicating genetic factors. (nih.gov)
  • In a genetic screen for factors that promoted Rb mutant cell death in Drosophila , we identified Psid, a regulatory subunit of N-terminal acetyltransferase B (NatB). (prolekare.cz)
  • 3 Consequently, researchers must attempt to tease out what must be a dynamic interplay among heterogeneous genetic backgrounds, diverse environmental factors, and differential etiologies in the pathogenesis of this disorder, all of which make attempts to understand the genetic basis of hypertension a challenge. (ahajournals.org)
  • Whereas some of the disagreement among reports must arise from the factors discussed above (ie, genetic, etiologic, and environmental heterogeneity), a substantial proportion may be because of poorly defined inclusion criteria or inadequate appreciation of the importance of statistical power and replication. (ahajournals.org)
  • Ear2 ligand binding domain is required for Rasd1 (zeige RASD1 ELISA Kits ) to alleviate Ear2 -mediated repression of renin (zeige REN ELISA Kits ) transcription. (antikoerper-online.de)
  • Birdsey GM, Shah AV, Dufton N et al (2015) The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling. (springer.com)
  • Together, our findings reveal a regulatory role of COUP-TFII in the development of muscular dystrophy and open up a potential therapeutic opportunity for managing disease progression in patients with DMD. (jci.org)
  • Ser118 may be the substrate of the transcription regulatory kinase CDK7, whereas Ser167 may be phosphorylated by p90RSK and Akt. (cellsignal.com)
  • Next, by generating double compound mutants between COUP-TFI and Pax6, I found that lowering the gene dosage of Pax6 in COUP-TFI mutants, and vice versa, of COUP-TFI in Pax6 mutants, rescued the reciprocal mutant phenotype. (unina.it)
  • Notably, topographic inputs from the entorhinal cortex are strongly impaired in the dorsal portion of COUP-TFI mutants. (ovid.com)
  • The COUP-TFI knockout ( COUP-TFI -/- ) has a significant increase in hair cell (HC) number in the mid-to-apical turns. (biologists.org)
  • Targeted deletion (knockout) of COUP-TFI results in defects in the formation of commissural projections in the forebrain due to impaired axonal growth, as well as defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. (nursa.org)
  • MUC13 also contains 3 epidermal growth factor (EGF)-like domains and a cytoplasmic domain containing potential phosphorylation sites, which could play a role in cell signaling. (aacrjournals.org)