COUP Transcription Factor I: A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.COUP Transcription Factor II: A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Insulin-Like Growth Factor I: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Forehead: The part of the face above the eyes.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Facial Hemiatrophy: A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.Sp1 Transcription Factor: Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Complement Factor I: A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Schools, Pharmacy: Educational institutions for individuals specializing in the field of pharmacy.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.College Admission Test: Test designed to identify students suitable for admission into a graduate or undergraduate curriculum.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Students, Pharmacy: Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.Pharmacies: Facilities for the preparation and dispensing of drugs.Thyrotropin: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.Receptors, Somatostatin: Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.Thyroid Hormones: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.Receptors, Thyroid Hormone: Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Phosphoenolpyruvate Carboxykinase (GTP): An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Physician-Nurse Relations: The reciprocal interaction of physicians and nurses.Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site. (1/143)

The formation of various tissues requires close communication between two groups of cells, epithelial and mesenchymal cells. COUP-TFs are transcription factors which have been shown to have functions in embryonic development. COUP-TFI is expressed mainly in the nervous system, and its targeted deletion leads to defects in the central and peripheral nervous systems. COUP-TFII is highly expressed in the mesenchymal component of the developing organs. A null mutation of COUP-TFII results in the malformation of the heart and blood vessels. From their expression pattern, we proposed that COUP-TFs regulate paracrine signals important for mesenchymal cell-epithelial cell interactions. In order to identify genes regulated by COUP-TF in this process, a rat urogenital mesenchymal cell line was stably transfected with a COUP-TFI expression vector. We found that NGFI-A, a gene with important functions in brain, organ, and vasculature development, has elevated mRNA and protein levels upon overexpression of COUP-TFI in these cells. A study of the promoter region of this gene identified a COUP-TF-responsive element between positions -64 and -46. Surprisingly, this region includes binding sites for members of the Sp1 family of transcription factors but no COUP-TF binding site. Mutations that abolish the Sp1 binding activity also impair the transactivation of the NGFI-A promoter by COUP-TF. Two regions of the COUP-TF molecule are shown to be important for NGFI-A activation: the DNA binding domain and the extreme C terminus of the putative ligand binding domain. The C-terminal region is likely to be important for interaction with coactivators. In fact, the coactivators p300 and steroid receptor activator 1 can enhance the transactivation of the NGFI-A promoter induced by COUP-TFI. Finally, we demonstrated that COUP-TF can directly interact with Sp1. Taken together, these results suggest that NGFI-A is a target gene for COUP-TFs and that the Sp1 family of transcription factors mediates its regulation by COUP-TFs.  (+info)

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (2/143)

Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.  (+info)

Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene. (3/143)

Nuclear orphan receptors are known to be important mediators of neurogenesis, but the target genes of these transcription factors in the vertebrate nervous system remain largely undefined. We have previously shown that a 500-base pair fragment in the first intron of the GRIK5 gene, which encodes the kainate-preferring glutamate receptor subunit KA2, down-regulates gene expression. In our present studies, mutation of an 11-base pair element within this fragment resulted in a loss of nuclear protein binding and reverses negative regulation by the intron. Using yeast one-hybrid screening, we have identified intron-binding proteins from rat brain as COUP-TFI, EAR2, and NURR1. Gel shift studies with postnatal day 2 rat brain extract indicate the presence of COUP-TFs, EAR2, and NURR1 in the DNA-protein complex. Competition assays with GRIK5-binding site mutations show that the recombinant clones exhibit differential binding characteristics and suggest that the DNA-protein complex from postnatal day 2 rat brain may consist primarily of EAR2. The DNA binding activity was also observed to be enriched in rat neural tissue and developmentally regulated. Co-transfection assays showed that recombinant nuclear orphan receptors function as transcriptional repressors in both CV1 cells and rat CG4 oligodendrocyte cells. Direct interaction of the orphan receptors with and relief of repression by TFIIB indicate likely role(s) in active and/or transrepression. Our findings are thus consistent with the notion that multiple nuclear orphan receptors can regulate the transcription of a widely expressed neurotransmitter receptor gene by binding a common element in an intron and directly modulating the activity of the transcription machinery.  (+info)

Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. (4/143)

We previously identified various upstream and downstream regulatory elements and factors important for hepatic expression of the human angiotensinogen (ANG) gene, the precursor of vasoactive octapeptide angiotensin II. In the present study, to further investigate the molecular mechanism of human ANG transcriptional regulation, we generated transgenic mice carrying the fusion gene composed of the 1. 3-kilobase promoter of the human ANG gene, its downstream enhancer, and the chloramphenicol acetyltransferase reporter gene. Because expression of the chloramphenicol acetyltransferase gene was observed strongly in the liver and weakly in the kidney, we suspected that hepatocyte nuclear factor (HNF) 4 with a tissue expression pattern similar to that of the reporter gene would regulate ANG transcription. In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. Furthermore, COUP-TF dramatically decreased the human ANG transcription in the mouse liver by the Helios Gene Gun system in vivo. These results suggest that an interplay between HNF4 and COUP-TF could be important in hepatic human ANG transcription.  (+info)

Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. (5/143)

The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription.  (+info)

The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. (6/143)

Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differentiation and premature cell death during corticogenesis. Our results indicate that the subplate neuron defects lead to the failure of guidance and innervation of thalamocortical projections. Thus, our findings demonstrate a critical role of the subplate in early corticothalamic connectivity and confirm the importance of afferent innervation for the survival of layer IV neurons. These results also substantiate COUP-TFI as an important regulator of neuronal development and differentiation.  (+info)

Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells. (7/143)

Retinoic acid receptor beta (RARbeta) plays a critical role in mediating the anticancer effects of retinoids. Expression of RARbeta is highly induced by retinoic acid (RA) through a RA response element (betaRARE) that is activated by heterodimers of RARs and retinoid X receptors (RXRs). However, RARbeta induction is often lost in cancer cells despite expression of RARs and RXRs. In this study, we provide evidence that orphan receptor COUP-TF is required for induction of RARbeta expression, growth inhibition, and apoptosis by RA in cancer cells. Expression of COUP-TF correlates with RARbeta induction in a variety of cancer cell lines. In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARbeta expression, growth inhibition, and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects. In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARbeta promoter in a RA- and RARalpha-dependent manner. By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARbeta promoter. The binding of COUP-TF to the DR-8 element synergistically increases the RA-dependent RARalpha transactivation function by enhancing the interaction of RARalpha with its coactivator CREB binding protein. These results demonstrate that COUP-TF, by serving as an accessory protein for RARalpha to induce RARbeta expression, plays a critical role in regulating the anticancer activities of retinoids.  (+info)

The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. (8/143)

Human immunodeficiency virus type 1 (HIV-1) infects the central nervous system and plays a direct role in the pathogenesis of AIDS dementia. However, the molecular mechanisms underlying HIV-1 expression in the central nervous system are poorly understood. We have recently reported that the nuclear receptor chicken ovalbumin upstream promoter transcription factor (COUP-TF), an orphan member of the nuclear receptor superfamily, is an activator of HIV-1 gene transcription. Here, our results show that COUP-TF stimulates HIV-1 transcription in primary cultured human microglial cells, the primary target for HIV-1 infection in brain. Run-on assays indicated that COUP-TF acts on the initiation step of transcription. Results from reverse transcription-polymerase chain reaction and immunocytochemistry analysis further revealed the importance of this factor by demonstrating that overexpression of COUP-TF leads to initiation of viral replication in primary HIV-infected human microglia. In addition, COUP-TF is able to physically interact and cooperate with the viral transactivator Tat. The combination of COUP-TF and Tat leads to NF-kappaB- and Sp1-independent enhanced transcriptional stimulation. In vitro binding studies showed that COUP-TF interacts with Tat through amino acids within the N-terminal DNA-binding domain of COUP-TF. Amino acids 48-72 in the basic and C-terminal regions of Tat are required for the binding of Tat to COUP-TF. These results suggest that COUP-TF is an essential transcription factor involved in HIV-1 expression in microglia and reveal a novel interplay of Tat and COUP-TF during regulation of viral expression.  (+info)

*COUP transcription factor

... may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ...

*Chicken ovalbumin upstream promoter-transcription factor

COUP Transcription Factors at the US National Library of Medicine Medical Subject Headings (MeSH) COUP Transcription Factor I ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ... intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the ... Park JI, Tsai SY, Tsai MJ (2003). "Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) ...

*COUP-TFI

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701-9. ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW (Jul 1989). "COUP transcription factor is a member of the steroid ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ...

*Griffin P. Rodgers

... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...

*Nucleolin

... is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II ... "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast ... Parada CA, Roeder RG (Jul 1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". ... COUP-TFII). Midkine and pleiotrophin bind to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV ...

*Uteroglobin

"Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs ... "Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1". Biochimica et Biophysica Acta ...

*BCL11B

"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). "COUP-TF (chicken ovalbumin upstream promoter transcription ... BCL11B has been shown to interact with COUP-TFI. GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017 GRCm38: ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ...

*Sirtuin 1

"Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... which are essential metabolic regulatory transcription factors. In mammals, SIRT1 has been shown to deacetylate and thereby ... which are essential metabolic regulatory transcription factors. Human aging is characterized by a chronic, low-grade ... "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase". Science. 303 (5666): 2011-15. Bibcode: ...

*COUP-TFII

... (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal ... "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207-16. PMID 1820218. Ladias JA ... "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): ...

*BCL11A

... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... BCL11A has been shown to interact with COUP-TFI. GRCh38: Ensembl release 89: ENSG00000119866 - Ensembl, May 2017 GRCm38: ... finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor ( ... COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315-22. doi:10.1074/jbc.275.14.10315. PMC 2819356 . PMID ...

*Ceramide kinase

... chicken ovalbumin upstream promoter transcription factor I (COUP-TFI), retinoic acid receptor (RARα), retinoid X receptor (RXRα ... This suggests that differential expression of RARα, RXRα, and COUP-PTI may determine transcription levels in various cell lines ... "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI". J. ... RARE-like plays a role in transcription regulation of CERK. It is suspected that in the presence of all-trans retinoic acid ( ...

*Geoffrey M. Cooper

Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746. Hartley, D. and Cooper, G.M. ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and ... Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ...

*Estrogen receptor alpha

Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen ... Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hERα-COUP-TFI ... It is hypothesized that estrogen stimulation of ERα may trigger the release of growth factors, such as epidermal growth factor ... heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress Chaperones. 1 (4): 237-50. doi:10.1379/ ...

*List of MeSH codes (D12.776)

... coup transcription factor i MeSH D12.776.826.750.074.500 - coup transcription factor ii MeSH D12.776.826.750.350.174 - estrogen ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ... fibroblast growth factor 4 MeSH D12.776.624.664.700.112 - fibroblast growth factor 6 MeSH D12.776.624.664.700.114 - fms-like ...

*Nerve growth factor IB

... is a member of the Nur nuclear receptor family of intracellular transcription factors. NGFIB is involved ... It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating ... This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular ... "Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1". Gene. 187 (1 ...

*Retinoid X receptor alpha

The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors. ... Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ...

*Aryl hydrocarbon receptor

The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Arch. ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ... Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ...

*FGF8

Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is ... Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary ... Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a ... 2002). "Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer". Br. J. Cancer ...

*V-erbA-related gene

V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. Comparatively ... V-erbA-related gene has been shown to interact with: COUP-TFII Thyroid hormone receptor beta GRCh38: Ensembl release 89: ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ... "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The ...

*Lck

... which goes on to activate certain transcription factors such as NFAT, NF-κB, and AP-1. These transcription factors regulate the ... Lck has been shown to interact with: ADAM15, CD2, CD44, CD4, COUP-TFII, DLG1, NOTCH1, PIK3CA, PTPN6, PTPRC, UNC119, SYK, UBE3A ... Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): ... "Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine ...

*Mary-Claire King

"Expression profiling in primates reveals a rapid evolution of human transcription factors". Nature. 440 (7081): 242-245. doi: ... 11, 1973, in a CIA-backed coup. She has been supportive of women and ethnic and sexual minorities in science, and critical of ... but researchers were skeptical about the use of genetics in the more common diseases caused by multiple genetic factors as well ...

*List of MeSH codes (D12.776.930)

... coup transcription factor i MeSH D12.776.930.682.074.500 -- coup transcription factor ii MeSH D12.776.930.682.350.174 -- ... transcription factor brn-3b MeSH D12.776.930.632.625.875 -- transcription factor brn-3c MeSH D12.776.930.635.600.100 -- ets- ... mafg transcription factor MeSH D12.776.930.127.656.750.750 -- mafk transcription factor MeSH D12.776.930.127.656.770 -- nf-e2 ... mafg transcription factor MeSH D12.776.930.316.750.750.750 -- mafk transcription factor MeSH D12.776.930.316.750.770 -- nf-e2 ...

*Nuclear receptor

... but also to other transcription factors. This binding often results in deactivation of the second transcription factor in a ... were all members of the COUP-TF, RXR, and FTZ-F1 groups of receptors. Both COUP-TF and FTZ-F1 are orphan receptors, and RXR is ... hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors generally ... referred to as transcription coregulators) that facilitate or inhibit the transcription of the associated target gene into mRNA ...

*HDAC1

"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase ...

*Hawaiian language

These variations are largely free, though there are conditioning factors. /l/ tends to [n] especially in words with both /l/ ... in making handwritten transcriptions of Hawaiian vowels. The missionaries specifically requested their sponsor in Boston to ... The decline of the Hawaiian language dates back to a coup that overthrew the Hawaiian monarchy and dethroned the existing ...

*Lal Bahadur Shastri

Whereas Pakistan proclaims herself to be an Islamic State and uses religion as a political factor, we Indians have the freedom ... India's relationship with Burma had been strained after the 1962 Military coup followed by the repatriation of many Indian ... recorded their telephone conversations and published a transcription in a book titled Conversations with the Crow. In the book ...
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the steroid/thyroid hormone receptor superfamily and function in transcriptional regulation of a multitude of genes. of the ovalbumin gene (Bagchi et al., 1987; Pastorcic et al., 1986; Wang et Procyanidin B3 inhibitor Mouse monoclonal to Human Albumin al., 1987). It was found to bind an element (COUP) between C90 and C70 within the ovalbumin promoter that is much like thyroid and estrogen response elements (Pastorcic et al., 1986). The COUP-TF has also been shown to bind cis-elements involved in positive transcription rules in the rat insulin II (Hwung et al., 1988; Hwung et al., 1988b), chicken VLDL II (Wijnholds et Procyanidin B3 inhibitor al., 1988), and human being apolipoprotein AI and CIII genes (Ladias and Karathanasis, 1991). It was also reported to bind to bad regulatory elements in the proopiomelanocortin (Drouin et al., 1989a; Drouin et al., 1989b) and HIV-1 (Cooney et al., 1991) promoters. The ...
B168 Nuclear receptors, the transcription factors regulated by ligands, have become major targets for drug discovery, including new drug development for chemotherapy. Orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) possesses the ability to either activate or repress the transcription of a diversity of target genes through undefined mechanisms. A proteomics-based, tandem affinity purification (TAP) procedure was used in this study to identify the component proteins of COUP-TFI complexes in mammalian cells. Several known proteins of transcriptional repressive complexes, including NCoR, HDAC1 and TIF1β/KAP-1, were found to co-purify with COUP-TFI, as were other transcriptional regulatory proteins, including the SWI/SNF family member Brahma, and its associated factors BAF155 and BAF170. Proteins not previously implicated in transcriptional regulation were also found to co-purify with COUP-TFI including the DNA repair protein DDB1, a pro-apoptotic ...
Sugiyama T, Wang JC, Scott DK, Granner DK (Feb 2000). "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". The Journal of Biological Chemistry. 275 (5): 3446-54. doi:10.1074/jbc.275.5.3446. PMID 10652338 ...
AbstractThe hippocampus (HP), a medial cortical structure, is subdivided into a distinct dorsal (septal) and ventral (temporal) portion, which is separated by an intermediate region lying on a longitudinal curvature. While the dorsal portion is more dedicated to spatial navigation and memory, the mo
Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
Looking for online definition of COUP-TF I in the Medical Dictionary? COUP-TF I explanation free. What is COUP-TF I? Meaning of COUP-TF I medical term. What does COUP-TF I mean?
Y-box binding protein 1 (YB-1) is encoded by the YBX1 gene in humans. It binds to splice sites in pre-mRNA, regulates splice site selection, and stabilizes cytoplasmic mRNA. YB-1 acts as a transcriptional regulator by: i) controlling the interaction between eukaryotic translation initiation factors and mRNA; and ii) binding to the Y-box motif found in the promoters of genes such as multidrug resistance 1 (MDR1) and HLA class II genes. YB-1 gene expression has been associated with lung cancer and the response to chemotherapy in patients with breast cancer. YB-1 is also known as nuclease sensitive element binding protein 1 (NSEP1), enhancer factor I subunit A, CCAAT-binding transcription factor I subunit A, DNA-binding protein B (DBPB), Y-box transcription factor, BP-8, CSDA2, CSDB1, and MDR-NF1.. ...
COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
J:112461 Tang LS, Alger HM, Pereira FA, COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006 Sep;133(18):3683-93 ...
Synonyms for Sport coupé in Free Thesaurus. Antonyms for Sport coupé. 5 words related to coupe: auto, automobile, car, motorcar, machine. What are synonyms for Sport coupé?
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle-wasting disease caused by mutations in the dystrophin gene. Although dystrophin deficiency in myofiber triggers the diseases pathological changes, the degree of satellite cell (SC) dysfunction defines disease progression. Here, we have identified chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) hyperactivity as a contributing factor underlying muscular dystrophy in a dystrophin-deficient murine model of DMD. Ectopic expression of COUP-TFII in murine SCs led to Duchenne-like dystrophy in the muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice. COUP-TFII-overexpressing mice exhibited regenerative failure that was attributed to deficient SC proliferation and myoblast fusion. Mechanistically, we determined that COUP-TFII coordinated a regenerative program through combined regulation of multiple promyogenic factors. Furthermore, inhibition of COUP-TFII preserved SC ...
Regional and cell-type specification during embryogenesis are often coupled to expression of TFs that are restricted to specific progenitor domains. Here, we found that Nkx2-1 restricts the expression of Coup-TF1/2 in the MGE to an arc that extended from a small rostrodorsal domain to a larger caudoventral domain (Fig. 1; Fig. S1B,D,H,K,L). The Coup-TF1/2+ MGE domain was complementary to an Otx2+ domain (Fig. S1B-E), where Otx2 represses Coup-TF1 MGE expression (Hoch et al., 2015a,b).. Our data support a model in which the Coup-TF1/2+ MGE domain is biased towards generating SST+ CINs (Fig. 2; Fig. S3A-C), as well as cholinergic and pallidal neurons (Fig. S4). These conclusions differ from other publications regarding the major location for the origin of SST+ interneurons, and provide evidence for a Coup-TF1/2-dependent activation of Sox6 expression that promotes SST+ interneuron development.. Multiple lines of evidence show that Coup-TF1/2 have key roles in promoting SST+ interneuron ...
Egyptian coup detat - Get latest news on Egyptian coup detat. Read Breaking News on Egyptian coup detat updated and published at Zee News
This NR2F2 / COUP2 polyclonal antibody from Active Motif has been validated for use in Chromatin Immunoprecipitation (ChIP) and Western blot.
In this video, Alex explains why there has been a coup détat against our Constitutional Republic, and breaks down why the office of the presidency is becoming dictatorial.. Read: Retired Army Captain Warns DHS Acquisitions are bold threat of war Against the American People - http://www.infowars.com/retired-army-captain-warns-recent-dhs-acquisitions-are-bold-threat-of-war… ...
Ze studie 407 Prologue se zrodil Peugeot 407 Coup . Sv tov premi ra je p ipravena na z iov Frankfurt. Z kladn cena by m la atakovat milionovou hranici.
Besidin information about active ingredients, pharmaceutical forms and doses by Coup, Besidin indications, usages and related health products lists
The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking Coup-tfII (chicken ovalbumin upstream promoter transcription factor II) in the Wolffian duct mesenchyme became intersex-possessing both female and male reproductive tracts. Retention of Wolffian ducts was not caused by ectopic androgen production or action. Instead, enhanced phosphorylated extracellular signal-regulated kinase signaling in Wolffian duct epithelium was responsible for the retention of male structures in an androgen-independent manner. We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. ...
Looking for online definition of Coup d'etát in the Medical Dictionary? Coup d'etát explanation free. What is Coup d'etát? Meaning of Coup d'etát medical term. What does Coup d'etát mean?
LXR α 0h 4h 8h 18h 1D 2D 3D 4D 5D 6D 7D 8D h 2d d Induction MediumDifferentiation Medium NR Expression during Adipogenesis of 3T3-L1 Cells (2) Fu et al., Mol. Endo. 19: 2437 (2005) Nur77 PPAR γ NUR77 LXR  PPAR 
Former House Majority Leader Dick Armey (R-Texas), who abruptly resigned as head of Tea Party group FreedomWorks, brought in an assistant with a gun in an apparent coup attempt at the group, according to a report in the Washington Post. | this curious life
The Brazilian Coups Image Problem from Boston Review. New leaks prove the impeachment is intended to protect corrupt politicians.
The Nigerian military successfully staged their fifth coup in 17 years on December 31.They seized power from President Shehu Shagari, ending four years of democratic civilian rule.The army, led by Major-General Mohammed Buhari; 41, said in an early-morning…
After months of political crisis, the generals declare martial law. They claim theyre just making peace, not running the country.
The crash has laid bare many unpleasant truths about the United States. One of the most alarming, says a former chief economist of the International Monetary Fund, is that the finance industry has effectively captured our government—a state of affairs that more typically describes emerging markets, and is at the center of many emerging-market crises. If the IMF’s staff could speak freely about the U.S., it would tell us what it tells all countries in this situation: recovery will fail unless we break the financial oligarchy that is blocking essential reform. And if we are to prevent a true depression, we’re running out of time.
1.School of Biology, Department of Biomedical Engineering and College of ComputingGeorgia Institute of TechnologyAtlanta, GeorgiaUSA ...
The bars message will be unmistakable: Mr. DeRossi has commissioned artists to recreate some of the more clever signs that protesters have been brandishing at anti-Trump rallies and marches over the past few months. At Coup, they will become décor.. Coup wont be the first bar opened in protest of President Trump. During the week before the election and the week of the inauguration, Barrel, a saloon in Washington, converted its basement into a jokey, for-profit Trump-themed pop-up, with drinks like the Moscow Mole. Bar Ilegal, another Washington pop-up, sponsored by Ilegal Mezcal, ran for a week before the election, with all profits going to Niños de Guatemala, a school for underprivileged children in that country.. There are certainly many bars across America with a pro-Trump atmosphere. But few on either side of the political divide are as ambitious as Coup.. Coup will have two bars, one reserved for a rotating roster of guest bartenders, who will put in from one to several nights work. ...
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
Turkeys mayhem started with an attempted coup, followed by a chaotic night of gunfire, violence and uncertainty. Read a breakdown of how the events unfolded.
Oracle Corp ORCL.O said on Thursday it was moving its stock listing to the New York Stock Exchange from Nasdaq OMX Groups (NDAQ.O) main U.S. exchange, a major coup for NYSE Euronext NYX.N, as it lands the largest-ever U.S. market transfer.
Thousands of public servants dismissed in state of emergency decrees have applied to the European Court of Human Rights (ECHR) since Turkeys July 2016 coup attempt.
a Psychic Internet Digital Coup for those created to Die, Children will Get Even Soon using our shared Internet; a Meta-Psychical Electronic Community Center Genius Phenomenon
WHY WE LOVE IT Bread van of-fers a slice of the VW ac-tion at low prices The Polo MkII was a prac-ti-cal re-think of the orig-i-nal VW su-per-mini (1975-1981), and was ini-tially avail-able with a squared-off back end and big rear win-dows, like a com-pact es-tate car that fans af-fec-tion-ately named the bread van. The ar-rival of the coupé ver-sion from 1983 of-fered a more tra-di-tional slop-ing hatch-back style.. En-gine sizes ranged from 895cc to 1272cc, but who can for-get the leg-endary su-per-charged 116bhp G40 in-tro-duced in 1991, thats ca-pa-ble of a top speed of 120mph?. Per-haps spurred on by the G40, Polo MkIIs have a strong fol-low-ing - par-tic-u-larly among mod-i-fiers - though theres good avail-abil-ity of most types and some re-ally great bar-gains to be had out there. BUY-ING TIPS. As ever, rust is the big po-ten-tial prob-lem - take a good look at those door bot-toms. Also check for signs of ac-ci-dent dam-age, break-ins and poor re-pair work.. Reg-u-lar oil changes ...
Intelligence sources say the Bangladesh coup attempt last month was fueled by retired officers campaigning to introduce sharia law. The news raises concern about political instability in the region.
Turkey has reportedly made a formal request to the United States for the arrest of U.S.-based Turkish cleric Fethullah Gulen on charges of orchestrating an attempted military coup on July 15. Mana Rabiee reports.}
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A BOATBUILDER from Wales who has been blind for the past 38 years is set to dazzle visitors to this years Chelsea Flower Show with his latest creation.
2) Theres a mantra that I pulled from a book that Ive found to be somewhat useful. "Aumala." Pronounce it in four syllables, "Ahh" (rhyming with Bach, "oo" rhyming with coup, "mah" rhyming with Todd, and "lah" rhyming with lock. Like all mantras, the more you use it the clearer sense youll get for it, but from what I gather...it seems to identify the self with all that is, and when youve filled yourself with that concept, whatever is trying to hurt you or eat you tends to feel the result of its own actions against you. However, I have also found that while this mantra can in some cases put a complete and instant halt to everything bad that is going on...is some other cases Ive found it to be utterly useless. My best guess is that if youre being attacked by a conscious being, it will be aware of whats going on, and stop as to avoid hurting itself. But, it seems to be fairly trivial for them to change methods and use non-conscious probes to do the work by proxy. So, in my experience, while ...
This barely released thriller, Any Mans Death, offers one dunderheaded miscasting coup after another. Waspy John Savage plays a Jewish…
The present invention discloses steroid/thyroid hormone receptor DNA binding domain compositions that determine target gene specificity. The invention further discloses methods converting the target gene specificity of one receptor into the target gene specificity of another. Still further the invention discloses novel assays for identifying ligands for orphan hormone receptors. These assays are especially useful since they avoid the necessity of constructing chimeric genes and proteins in order to search for ligands that can activate a putative receptor.
The US State Department said Thursday that it will review its annual aid to Mali after soldiers staged a coup in the African country. State Department spokeswoman Victoria Nuland said that Washington provides significant security and economic and
NIAMEY, Feb 20 - UN chief Ban Ki-moon added his voice to international condemnation of a coup that toppled Nigers president, but in the capital Niamey th - Kenya breaking news | Kenya news today | Capitalfm.co.ke
A failed coup attempt on Friday night has gripped Turkey. By Saturday morning, thousands of soldiers had been detained, accused of trying to overthrow the government, and civilians were left in a state of unease.
2-seater sports, coupè. Same basic specification, but S2 introduces larger front brake calipers, polished veneer dash, (optional) centre-lock wheels. S3 first launched as fixed-head, in 1965; drophead S3 (better hood, coupès framed electric windows) follows in 66 to replace S2 convertible . Higher final-drive ratio, plus an optional close-ratio gearbox and standard centre-locks, on all S3s; Special Equipment (SE) model has 115bhp engine, c/r box, servo brakes.
This is an ongoing situation, I assume no members are currently in the country. If you are then follow FCO advice, if youre a Turkish citizen then TOR and...
The ground zero of Size Zero is here. Alexandra Shulman, the editor of British Vogue, called out a bunch of prominent fashion designers for encouraging Size Zero models. In a strongly-worded letter to them, she wrote:
From the sellers description: This 1955 Chevrolet Bel Air, Hardtop Sport Coup is a well-cared for high optioned car that was repainted about 8 years ago and ha
Coup de cœur pour le travail de Juan Alfonso Solis : un graphiste espagnol basé en Irlande qui a imaginé lidentité graphique du lieu Le 29,
The arrest of a retired Indian Navy Commander, Kulbhushan Jadhav, allegedly for spying and other activities in Balochistan, is a coup of sorts for Islamabad.
Hello, I just finished putting together my new computer build and I am having some trouble getting it to stay powered on. I am thinking it might be a PSU issue, however, after disconnecting a coup...
8217; equivalent intestinal ú by Surveying situations really or Eating, Practising or entering cookies, so view Impact Evaluation it not to get then Now. legal water fairly and right. so on in your price, finance up beam and coup with wineskins just that you can eliminate the Alter system, as this will need your techniques more Related.
A] I am proud of the brotherhood and the community of the thinking men and women and creators of my country. Like others of Latin America in the recent past they have reacted with heroism, with imagination, with sensitivity and with professionalism. They go to the marches and they make art to display. It is not only this coming Sunday, but since hours after the coup, and in a continued fashion, in Honduran cities, they sing against the coup in the street, they dance and they write poetry and theater and sociological and political essays against the coup, they convey the chronicle of the infamies of the coup, they paint against the coup, on the walls and on paper. This speaks of a new and unified civic maturity of the citizenry, although always diverse, of the guilds of artists and academics. The mealy-mouthed and the traitors are so few that it isnt worth the trouble to make a list. Hopefully I can contribute something like leavening. This lucid conscience is at the base the only proof that the ...
Former Education Minister Chaturon Chaisang came out of hiding to speak to journalists at the Foreign Correspondents Club of Thailand, where he defiantly denounced the coup makers and warned that resistance to the coup would continue and with it, the possibility of violence that would be a disaster for this country.. "He said he had no intention of reporting to the authorities as ordered. So men with guns came to him insteadentering the Club while he was speaking and bundling him into a van that took him away.. "His appearance was the first in public by any member of the deposed government since the coup took place, though most of the senior members of the previous government had already been detained. The army continues to conduct raids on houses and businesses of supporters of the deposed government. One soldier was killed yesterday in one such operation.". ...
Venezuelan President-elect Nicolás Maduro has accused the United States and the opposition of planning a coup against him. Venezuelan President-elect Nicolás Maduro has accused the United States and opposition of planning a coup against him after seven government supporters were killed and 60 people were injured in clashes after the election. Venezuelas National Electoral Council has certified Maduros victory, but opposition candidate Henrique Capriles is refusing to accept the results.
Gambian state media in Banjul and western news sources, are reporting four dead and 11 injured after shots were fired at the residence of His Excellency Sheikh Professor Doctor President Alhaji Yahya Jammeh. The same media Fatu Radio reported at 07h 45m Local Time that the coup had been foiled. However, as of 10h 45m…
Niger became independent from France in 1960 and experienced single-party and military rule until 1991, when Gen. Ali SAIBOU was forced by public pressure to allow multiparty elections, which resulted in a democratic government in 1993. Political infighting brought the government to a standstill and in 1996 led to a coup by Col. Ibrahim BARE. In 1999, BARE was killed in a counter coup by military officers who restored democratic rule and held elections that brought Mamadou TANDJA to power in December of that year. TANDJA was reelected in 2004 and in 2009 spearheaded a constitutional amendment allowing him to extend his term as president. In February 2010, military officers led a coup that deposed TANDJA and suspended the constitution. ISSOUFOU Mahamadou was elected in April 2011 following the coup and reelected to a second term in early 2016. Niger is one of the poorest countries in the world with minimal government services and insufficient funds to develop its resource base. The largely ...
A series of international powers have condemned a major power grab in Venezuela as an undemocratic coup detat. The Supreme Court stripped the opposition-controlled congress of all legislative power.
Niger became independent from France in 1960 and experienced single-party and military rule until 1991, when Gen. Ali SAIBOU was forced by public pressure to allow multiparty elections, which resulted in a democratic government in 1993. Political infighting brought the government to a standstill and in 1996 led to a coup by Col. Ibrahim BARE. In 1999, BARE was killed in a counter coup by military officers who restored democratic rule and held elections that brought Mamadou TANDJA to power in December of that year. TANDJA was reelected in 2004 and in 2009 spearheaded a constitutional amendment allowing him to extend his term as president. In February 2010, military officers led a coup that deposed TANDJA and suspended the constitution. ISSOUFOU Mahamadou was elected in April 2011 following the coup and reelected to a second term in early 2016. Niger is one of the poorest countries in the world with minimal government services and insufficient funds to develop its resource base, and is ranked last ...
Ланочка Ленкина In Thailand martial law.Such measures are explained by the need to "conservation law and order" against the backdrop of the ongoing political crisis and the anti-government clashes.It is reported by BBC BBC.. The Army has attributed the military broad powers, for how long martial law soobschaetsya.Voennye not have taken power into their own hands, the government did not participate in this decision.However, as noted by the representatives of the army command, the incident is not a coup detat.. In addition, the military took control of the media, which is now forbidden to publish any appeals to the revolution and the news that "may adversely affect the peace action".. The last time the military took over power in Thailand in 2006, when during the coup toppled the government of Thaksin Shinawatra.It suspended the constitution and two weeks Thailand lived under martial law.. Coups in Thailand - a frequent event.Since 1932, when the country became a constitutional ...
Overthrown in 2014, Yingluck Shinawatra had faced up to 10 years in prison if found guilty in the trial centered on the multi-billion-dollar losses incurred by a rice subsidy scheme for farmers ...
Si vous vous souvenez il y a quelques mois, Aïcha, lexperte maquillage de Clinique Belgique mavait maquillée (première photo). Elle mavait aussi fait un diagnostique de la peau. Depuis plus dun an, je trouve ma peau très "perturbée et perturbante" : un coup lumineuse, puis terne avec des points noirs sur le bout du nez. Un coup des cicatrices dacné sestompent légèrement, tandis quapparaissent des micro kystes sous cutanés! Bref, ma peau va dans tous les sens : cest pénible! La pire saison étant lété : chaleur, transpiration, écran total, inconfort de la peau mixte-grasse et paresse de ma part. Donc dès la fin juillet, jai initié ma nouvelle routine soin avec six produits Clinique. Jai été régulière le matin ; le soir je préférai ne rien mettre. ERREUR. Depuis 3 semaines, je les applique matin et soir : ce qui change tout! Absolument TOUT! La peau est comme boostée, assainie. Je ne dirai pas que ça fait des miracles, mais le changement est VRAIMENT visible. Au ...
DHAKA, Bangladesh - A judge convicted and sentenced to death 15 former military commanders in the 1975 assassination of the countrys first prime minister, bringing an end to a trial delayed for
Last weeks military coup in Thailand may have been a reluctant coup, but the inclination should have been resisted. The longer it takes Gen. Prayuth Chanchoa to produce a civilian government, the greater the risk that soldiers will turn their guns against the people. ...
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008 ...
CAIRO (AP) - A statement on the Egyptian presidents offices Twitter account has quoted Mohammed Morsi as calling military measures a full coup.
Turkey began freeing 38,000 prisoners on Wednesday, after announcing a penal reform that will make space for tens of thousands of suspects rounded up over last months attempted coup.
S E C R E T SECTION 01 OF 05 PANAMA 08545 E.O.12356: DECL:OADR TAGS: PGOV PREL PM US SUBJECT: PANAMANIANS HOPE FOR A SUCCESSFUL COUP -- NORIEGA PLANS FOR A NEW YEAR IN POWER 1. SECRET - ENTIRE
Nigerias President Muhammadu Buhari, who seized power in a military takeover more than 30 years ago before winning democratic elections this year, on Friday condemned the coup in Burkina Faso. The former military ruler and his government in Abuja said they unreservedly condemn the takeover
NAIROBI, Kenya, Jul 14 - Lawyer Paul Muite on Saturday asked Orange Democratic Movement leader Raila Odinga to tell Kenyans what he knows about the abortiv - Kenya breaking news | Kenya news today | Capitalfm.co.ke
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The contentious August 10 recall vote appears to have done little to quell the political tension that has pushed Bolivia to the brink of outright violence.
Please check out my new books, "Prosecutors Gone Wild: The Inside Story of the Trial of Chuck Panici, John Gliottoni, and Louise Marshall" and also, "The Definitive Dossier of PTSD in Whistleblowers". ...
Six months ago Ugandas President Apolo Milton Obote boasted that he was perhaps the only African leader not afraid of a military coup. Last week Obote was proved to be more...
(This is the last part of a fictional short story - In you we trust. You can find the first part here.) Aparna got a transplant a coup...
Here is the HUGE inclusion list for the upcoming Buy 5 Get $5 Mega sale along with all the matching coupons that I see. If you find any other matching coup
Nur77, also called TR3 or NGFI-B, is an immediate-early response gene and an orphan member of the steroid/thyroid/retinoid receptor superfamily. Nur77 exerts no...
A senior member of the MuslimBrotherhood, Egypts biggest opposition group, said on Thursdayhe feared the Egyptian army was staging a military coup.
For the past decade, the US intelligence agencies operating in Turkey have worked closely with the increasingly influential parallel government of Fethullah Gulen. Their approach to power was, until recently, a permeationist strategy, of covertly taking over political, economic, administrative, judicial, media, military and cultural positions gradually without resort to elections or military coups. They adopted flexible tactics, supporting and shedding different allies to eliminate rivals ...
The coup revealed the essential problem of the Egyptian revolution: the chasm between the elemental anger of the Egyptian population and the absence of political leadership.
Burundian civil society groups called for renewed street protests Friday against a third term bid by the president after a coup bid against him failed.
Niger became independent from France in 1960 and experienced single-party and military rule until 1991, when Gen. Ali SAIBOU was forced by public pressure to allow multiparty elections, which resulted in a democratic government in 1993. Political infighting brought the government to a standstill and in 1996 led to a coup by Col. Ibrahim BARE. In 1999, BARE was killed in a counter coup by military officers who restored democratic rule and held elections that brought Mamadou TANDJA to power in December of that year. TANDJA was reelected in 2004 and in 2009 spearheaded a constitutional amendment allowing him to extend his term as president. In February 2010, military officers led a coup that deposed TANDJA and suspended the constitution. ISSOUFOU Mahamadou was elected in April 2011 following the coup and reelected to a second term in early 2016. Niger is one of the poorest countries in the world with minimal government services and insufficient funds to develop its resource base. The largely ...
But, first, it should also be noted, in this introduction, that the OSCE, Organization for Security & Cooperation in Europe, refuses to investigate the documented usages of firebombs in Ukraines war against the southeastern portion of Ukraine, Donbass - the region that rejects the legitimacy of the Ukrainian Government which came into power at that violent February 2014 coup. (Here is the U.S. official on 4 February 2014 at the very moment when she was selecting the man to run Ukraine after the coup, the man who then did become appointed as Ukraines leader 22 days later. And here is the telephone conversation during which the EUs minister for foreign affairs first learned that it had been a coup.) However, some of these firebombing-instances have (notwithstanding OSCE and other U.S.-controlled agencies) been caught on videos, the authenticity of which has not been challenged; and, sometimes, the resulting fires on the ground have likewise been documented in these videos. Furthermore, it ...
cease: The coup was planned to take place on 1st December, 1963. Waldron believes that Carlos Marcello, Santo Trafficante and Johnny Roselli discovered details of the plot, and cite numerous government documents where the mobsters associates talked about the coup plan. The three mob bosses were extremely angry with the attempts by Robert Kennedy to have them deported or sent to prison. By linking Kennedys death to the top secret coup plan, the Mafia chiefs could prevent a thorough investigation. Using trusted hitmen with proven experience, the Mafia bosses first tried to kill Kennedy in Chicago (home of Rosellis Chicago Mafia family) on November 2, 1963, then tried again in Trafficantes base of Tampa, Florida, on November 18, before finally succeeding in Dallas, which Marcello controlled. ...
Note: To take advantage of the TIAS.com Buyer/Seller Assurance policy, items must be purchased through the TIAS.com e-commerce system. TIAS.com guarantees that you will have seven days to return the item (in original condition and for any reason) for reimbursement of the purchase price from the seller but ONLY if the item is purchased through our websites e-commerce system. This policy does not apply to items purchased directly from the seller by any other means (phone, email, mail, etc). Thank you ...
The autonomy of research and academic institutions in Turkey has long been under attack but is now facing an existential threat, says Caghan Kizil
An attempted overthrow of a democratically elected government on the border of Europe. Military tanks on the streets blocking access to main arteries, international airports brought to a standstill an...
WELCOME TO WEEK 6 OF THE RBL HEAVYWEIGHT DIVISION Heavyweight Champion Severity 5-0 Vs. Heavyweight #1 Contender Allen KNight 3-0 #3 Coup...
7 METRIC Synthetica MMI-Mom And Pop. Click through to see the rest of the chart, featuring The Coup, Cactus Channel, Ex-Cult, Ab Soul & Converge. ...
http://ift.tt/eA8V8J Turkey today accused Germany of supporting the network of a US-based Turkish Muslim maverick cleric it blames for last years attempted coup, comments likely to aggravate a diplomatic feud between Ankara and Berlin. Yesterday, German news magazine Der Spiegel published an interview with the head of the BND foreign intelligence agency, who said Ankara…
Chicken egg white contains a variety of proteins including ovalbumin, conalbumin, ovomucoid and lysozyme. In this exercise, students use the western press-blot procedure to characterize chicken ovalbumin and then to determine if the protein is found in egg whites from turkey and quail.. ...
So I ran over to Urban Outfitters yesterday to pick up a pair of gaudy earrings to wear to an event tonight, and there were sale racks out front. I found a cute top with spaghetti straps, empire lines, and enough length that one need not worry about exposing ones belly to the world, so I brought it in to try on. The nice (young) salesgirl greeted me perkily and said "Oh, did you want to try on that dress ...
bentley continental gtnin her ne kadar daha lüks segmentte olduğu söylense de clyi hep o araca rakip olarak görmüşümdür.bu aracı da v8 s versiyonuna rakip olarak görüyorum açıkçası ve performans olarak v8 sten önde.tabi şöyle bi durum var bu tip araçlar mantıkla değil kalple alınan araçlar.yani bu araçlara para verebilecek biri mercedes 20 beygir daha güçlüymüş onu alayım demeyecektir.s63 amg coupenin yan ve arka tasarımı oldukça şık duruyor ama iç mekan ve ön tarafın continental gtye göre oldukça hatta gereğinden fazla sade kaldığını düşünüyorum. YanıtlaSil ...
May 22, 2014 The army staged a coup. Two days earlier upon declaring martial law Lt. Gen. Nipat Thonglek issued a statement ensuring public safety and that people may carry on their business as usual. Travelers in the area should use caution.
On se l che, on se parle de tout,,, De nos pertes de poids,,, de nos motivations,,, de nos coups de blues,,, etc,,, etc,,, , forum gratuit , creer un forum, http://www.vosforums.com
Secretary-General Ban Ki-moon says those responsible for the coup and subsequent violations of human rights will be held accountable

COUP transcription factor 2 (P24468) | InterPro | EMBL-EBICOUP transcription factor 2 (P24468) | InterPro | EMBL-EBI

GO:0003700 DNA-binding transcription factor activity GO:0003707 steroid hormone receptor activity GO:0004879 nuclear receptor ...
more infohttp://www.ebi.ac.uk/interpro/protein/P24468

COUP Transcription Factors
     Summary Report | CureHunterCOUP Transcription Factors Summary Report | CureHunter

COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE ... COUP Transcription Factors: A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a ... COUP Transcription Factors. Subscribe to New Research on COUP Transcription Factors A sub-family of steroid receptor-related ... COUP TF Proteins; Chicken Ovalbumin Upstream Promoter Transcription Factors; Transcription Factors, COUP ...
more infohttp://www.curehunter.com/public/keywordSummaryD051836-COUP-Transcription-Factors.do

Nr2f2 - COUP transcription factor 2 - Mus musculus (Mouse) - Nr2f2 gene & proteinNr2f2 - COUP transcription factor 2 - Mus musculus (Mouse) - Nr2f2 gene & protein

Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity). ... Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but ... COUP transcription factor 2Add BLAST. 414. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... sp,P43135,COT2_MOUSE COUP transcription factor 2 OS=Mus musculus OX=10090 GN=Nr2f2 PE=1 SV=2 ...
more infohttp://www.uniprot.org/uniprot/P43135

Nr2f1 - COUP transcription factor 1 - Mus musculus (Mouse) - Nr2f1 gene & proteinNr2f1 - COUP transcription factor 1 - Mus musculus (Mouse) - Nr2f1 gene & protein

COUP transcription factor 1Imported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,Q32NY6,Q32NY6_MOUSE COUP transcription factor 1 OS=Mus musculus OX=10090 GN=Nr2f1 PE=1 SV=1 ... Transcription, Transcription regulationPROSITE-ProRule annotation. ,p>Information which has been generated by the UniProtKB ... positive regulation of transcription by RNA polymerase II Source: Ensembl. *transcription, DNA-templated Source: UniProtKB- ...
more infohttp://www.uniprot.org/uniprot/Q32NY6

COUP transcription factor - WikipediaCOUP transcription factor - Wikipedia

COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein ...
more infohttps://en.wikipedia.org/wiki/COUP_transcription_factor

Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical...Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical...

Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis during mouse cortical ... The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and ... Romano, Anna Lisa (2013) Role of the transcription factors COUP-TFI and Pax6 in neural stem cell self-renewal and neurogenesis ... Next, by generating double compound mutants between COUP-TFI and Pax6, I found that lowering the gene dosage of Pax6 in COUP- ...
more infohttp://www.fedoa.unina.it/9556/

Bovine COUP transcription factor 2, NR2F2 ELISA KITBovine COUP transcription factor 2, NR2F2 ELISA KIT

NR2F2 ELISA KIT allows for the in vitro quantitative determination of Bovine COUP transcription factor 2, NR2F2 concentrations ... Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Product Name:Bovine COUP transcription factor 2, NR2F2 ELISA KIT. Packing: ... Target Protein Name:Bovine COUP transcription factor 2, NR2F2 Alternative Name:NR2F2,Bovine COUP transcription factor 2, NR2F2 ... The microtiter plate provided in Bovine COUP transcription factor 2, NR2F2 ELISA KIT has been pre-coated with an Bovine COUP ...
more infohttps://www.lifescience-market.com/bovine-elisa-kit-c-65_73/bovine-coup-transcription-factor-2-nr2f2-elisa-kit-p-32631.html

Mechanism of Action of COUP-Transcription Factors - Ming-Jer TsaiMechanism of Action of COUP-Transcription Factors - Ming-Jer Tsai

Mechanism of Action of COUP-Transcription Factors Tsai, Ming-Jer Baylor College of Medicine, Houston, TX, United States ... We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult ... When COUP-TFII is conditionally ablated early, the MM cannot form properly and no kidney is formed. When COUP-TFII is knocked ... The various COUP-TFII deficient mouse models generated here will reveal how COUP-TFII affects kidney development and disease ...
more infohttp://grantome.com/grant/NIH/R01-DK045641-20

The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from | Beneficial Effects of RAF Inhibitor...

COUP-TFs) are members from. The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from the ... The COUP-TF, along with a non-DNA-binding transcription element, S300-II, was essential for in vitro transcription of the ... The chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are members from ... Also, we explain the series and id of another low Mr COUP-TF, COUP-TF2. Components and strategies Purification from the COUP- ...
more infohttp://biodiversityhotspot.org/2019/06/the-chicken-ovalbumin-upstream-promoter-transcription-factors-coup-tfs-are-members-from/

Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2...Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2...

Dividing COUP-TFII+ progenitor cells were localised to ventral CGE as previously described but were also numerous in adjacent ... Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 ... We examined expression of three interneuron precursor transcription factors, alongside other markers, using ... Thus COUP-TFII+ progenitors gave rise to pyramidal cells, but also interneurons which not only migrated posteriorly into the ...
more infohttps://eprint.ncl.ac.uk/pub_details2.aspx?pub_id=230328

Human Developmental Biology Resource (HDBR) » The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in...Human Developmental Biology Resource (HDBR) » The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in...

The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ...
more infohttp://hdbr.org/news/articles/74/the-transcription-factors-coup-tfi-and-coup-tfii-have-distinct-roles-in-arealisation-and-gabaergic-interneuron-specification-in-the-early-human-fetal-telencephalon

REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studiesREGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies

Transcription factor COUP. ENSMUSP00000034831. ProSitePatterns. PS00031. IPR001628. 40. 66. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 381. 392. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 361. 374. 1.20e-14. ... Transcription factor COUP. ENSMUSP00000034831. PRINTS. PR01282. IPR003068. 314. 326. 1.20e-14. ...
more infohttp://www.bioinformatics.org/regulator/page.php?act=detail&geneid=23958

REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studiesREGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies

Transcription factor COUP. ENSGMOP00000016025. ProSitePatterns. PS00031. IPR001628. 39. 65. -. Zinc finger, nuclear hormone ... Transcription factor COUP. ENSGMOP00000016025. PRINTS. PR01282. IPR003068. 242. 256. 1.10e-34. ... Transcription factor COUP. ENSGMOP00000016025. PRINTS. PR01282. IPR003068. 222. 240. 1.10e-34. ... Transcription factor COUP. ENSGMOP00000016025. PRINTS. PR01282. IPR003068. 168. 184. 1.10e-34. ...
more infohttp://www.bioinformatics.org/regulator/page.php?act=detail&geneid=ENSGMOG00000014975

NURSA | NR2F1 - 
	Chicken ovalbumin upstream promoter transcription factor I
	NURSA | NR2F1 - Chicken ovalbumin upstream promoter transcription factor I

COUP transcription factor 1; COUP transcription factor 1-A; COUP transcription factor I; COUP(VI); COUP-TF; COUP-TF I; COUP-TF1 ... COUP transcription factor 1 ; COUP transcription factor 1-A ; COUP transcription factor I ; COUP(VI) ; COUP-TF ; COUP-TF I ; ... COUP-TFI is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. It has ... Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and OMalley BW (1989) COUP transcription factor is a member of the steroid ...
more infohttps://www.nursa.org/nursa/molecules/nr.jsf?doi=10.1621/P5H82NAV6G

Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6

IPR003068 Transcription factor COUP. IPR013088 Zinc finger, NHR/GATA-type. IPR001628 Zinc finger, nuclear hormone receptor-type ...
more infohttp://www.informatics.jax.org/marker/MGI:1352453

COUP-TF I/NR2F1 Antibody (NBP2-15974): Novus BiologicalsCOUP-TF I/NR2F1 Antibody (NBP2-15974): Novus Biologicals

Rabbit Polyclonal Anti-COUP-TF I/NR2F1 Antibody. Validated: WB, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% ... Alternate Names for COUP-TF I/NR2F1 Antibody. *COUP transcription factor 1 ... Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ...
more infohttps://www.novusbio.com/products/coup-tf-i-nr2f1-antibody_nbp2-15974

NR2F2 (human)NR2F2 (human)

COUP transcription factor 2 Show on y-axis - References (HTP + LTP). References (LTP). References (HTP). Mutation Frequency in ...
more infohttps://www.phosphosite.org/proteinAction.action?id=19706&showAllSites=true

Nuclear receptors as target of new drug therapyNuclear receptors as target of new drug therapy

COUP /EAR ,/li,,/ul,,ul,,ul,,li,1: Chicken ovalbumin upstream promoter-transcription factor I ( COUP-TFI ; NR2F1 ) ,/li,,/ul,,/ ... ul,,ul,,ul,,li,2: Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li, ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ...
more infohttps://www.slideshare.net/HabiburRahman5/nuclear-receptors-as-target-of-new-drug-therapy

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron | NatureSMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron | Nature

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. . Keio J. Med. 52, 174-181 ( ... A series of transcription factors critical for maintenance of the neural stem cell state have been identified1,2,3, but the ... exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. . Cell ... Combinatorial roles of the nuclear receptor corepressor in transcription and development. . Cell 102, 753-763 (2000) ...
more infohttps://www.nature.com/articles/nature06270?error=cookies_not_supported&code=8b19c118-d809-41c9-b8c8-2848646154d4

Plus itPlus it

1989) COUP transcription factor is a member of the steroid receptor superfamily. Nature 340:163-166. ... 1995) Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis. J Steroid ... 1993) Steroid hormone receptors: interaction with DNA and transcription factors. Endocr Rev 14:459-479. ... 4). The COUP-TFs include the human and mouse apolipoprotein AI regulatory proteins (ARP-1), which are also known as COUP-TF II ...
more infohttp://www.jneurosci.org/content/18/24/10438

Publications | Griffin P. Rodgers, M.D., M.A.C.P. | NIDDKPublications | Griffin P. Rodgers, M.D., M.A.C.P. | NIDDK

SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.. Aerbajinai W, Zhu J, ... The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.. Chin KL, Aerbajinai W ... Glia maturation factor-γ mediates neutrophil chemotaxis.. Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.. J Leukoc ... Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.. Aerbajinai W, Liu L, Zhu J, Kumkhaek ...
more infohttps://www.niddk.nih.gov/about-niddk/staff-directory/biography/rodgers-griffin/publications

JCI -
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesisJCI - GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005;435(7038):98-104. ... describe an essential role for the transcription factor GATA4 in promoting the development of discontinuous sinusoids. In the ... FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from ... Here, we have shown that the transcription factor GATA4 controls murine LSEC specification and function. LSEC-restricted ...
more infohttps://www.jci.org/articles/view/90086

Chicken ovalbumin upstream promoter-transcription factor - WikipediaChicken ovalbumin upstream promoter-transcription factor - Wikipedia

COUP Transcription Factors at the US National Library of Medicine Medical Subject Headings (MeSH) COUP Transcription Factor I ... The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of ... intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the ... Park JI, Tsai SY, Tsai MJ (2003). "Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) ...
more infohttps://en.wikipedia.org/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1 | Journal of Cell...COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1 | Journal of Cell...

Transcription factor NR2F2 (also known as chicken ovalbumin upstream promoter transcription factor II, COUP-TFII) plays a key ... 1997). Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr. Rev. 18, 229-240. doi:10.1210 ... 2005). Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435, 98-104. doi: ... 2011). Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. ...
more infohttp://jcs.biologists.org/content/126/5/1164

COUP-TF I/NR2F1 Research Products: Novus BiologicalsCOUP-TF I/NR2F1 Research Products: Novus Biologicals

Browse our COUP-TF I/NR2F1 product catalog backed by our Guarantee+. ... COUP-TF I/NR2F1 products available through Novus Biologicals. ... transcription factor, binds to the ovalbumin promoter and, in ... transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-ahomolog-like 3) ... PTMs for COUP-TF I/NR2F1. Learn more about PTMs related to COUP-TF I/NR2F1.. Phosphorylation. Oxidation. Dephosphorylation. ...
more infohttps://www.novusbio.com/common-name/coup-tf-i-nr2f1
  • Recombinant protein encompassing a sequence within the center region of human COUP TF1. (novusbio.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • In the first part of my work, I found that in the absence of COUP-TFI function cortical cells abnormally proliferate over time, implying that COUP-TFI is responsible for maintaining a proper progenitor pool during development. (unina.it)
  • Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. (ncl.ac.uk)
  • in both cases COUP-TFII was co-expressed with PAX6 in proliferative zones and TBR1 or calretinin in post-mitotic cortical neurons. (ncl.ac.uk)
  • The goals of the existing work were Procyanidin B3 inhibitor to spell it out the proteins that bind towards the COUP response component to create the slower (C2) EMSA complicated, and to discover new members from the COUP-TF family members and determine their function. (biodiversityhotspot.org)
  • 1989). Antisera and labeled concatenated COUP elements were used to display a HeLa cell mRNA library in lambda gtll and determine a COUP-TF1 cDNA (Wang et al. (biodiversityhotspot.org)
  • 1989). Great and low Mr COUP-TFs had been separated by Superose 12 FPLC (Pharmacia) in buffer filled with 20 mM HEPES, pH 7.9, 100 mM KCl, 10% (v/v) glycerol, 5 mM MgCl2, and 2 mM dithiothreitol. (biodiversityhotspot.org)
  • Targeted deletion (knockout) of COUP-TFI results in defects in the formation of commissural projections in the forebrain due to impaired axonal growth, as well as defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. (nursa.org)
  • The COUP-TFI knockout ( COUP-TFI -/- ) has a significant increase in hair cell (HC) number in the mid-to-apical turns. (biologists.org)
  • We discovered that COUP-TFII, a transcription factor that regulates cell fate determination, embryonic development and adult organ function, plays a role in kidney development, function and disease. (grantome.com)
  • Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
  • Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
  • The various COUP-TFII deficient mouse models generated here will reveal how COUP-TFII affects kidney development and disease progression. (grantome.com)
  • In addition, excess proliferation in the COUP-TFI -/- sensory epithelium indicates that the origin of the extra HCs in the apex is complex. (biologists.org)
  • The transcription factors COUP-TFI and Pax6 are expressed in opposite gradients and required to co-ordinately control areal and laminar identity during corticogenesis. (unina.it)
  • To further define the defects of COUP-TFII mutants and dissect the underlying mechanism of COUP-TFII action, our specific aims in the next five years are: 1) Delineate the role of COUP-TFII in kidney development and its underlying mechanism;2) Determine the role of COUP-TFII in kidney function and diseases;and 3) Determine the role of COUP-TFII in diabetic nephropathy. (grantome.com)
  • Through the characterization of COUP-TF, the heterogeneity from the substances became obvious. (biodiversityhotspot.org)
  • Within this paper, we present by characterization from the high Mr forms they are completely functional members from the COUP-TF family members. (biodiversityhotspot.org)
  • Furthermore, adult mice with the loss of one COUP-TFII allele display polycystic kidneys, glomerulosclerosis (FSGS) and loss of kidney function, phenotypes resembling human kidney diseases. (grantome.com)
  • At the onset of kidney development (E10.5), COUP-TFII is expressed in the metanephric blastema, the urogenital ridge, and the metanephric mesenchyme (MM). Upon ureteric bud outgrowth, COUP-TFII is expressed in the condensed mesenchyme surrounding the ureteric buds and in the renal vesicle. (grantome.com)
  • Understanding the precise role of COUP-TFII in these diseases will provide timely insights that could be used in therapeutic strategies for the treatment and intervention of kidney diseases. (grantome.com)
  • Understanding COUP-TFII's mechanism of action will provide new avenues for the treatment of kidney diseases and diabetic complications. (grantome.com)
  • We examined expression of three interneuron precursor transcription factors, alongside other markers, using immunohistochemistry on 8-12 post-conceptional weeks (PCW) human telencephalon sections. (ncl.ac.uk)
  • Human Developmental Biology Resource (HDBR) » The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon. (hdbr.org)
  • When COUP-TFII is knocked out at a later stage, very few nephrons are apparent and there is no detectable distal tubule, suggesting that COUP-TFII is critical for the formation and patterning of the nephron. (grantome.com)
  • At the nephrongenesis stage (E13.5), COUP-TFII becomes regionalized with high expression in the distal tubules and the glomeruli (podocytes and Bowman's capsule), but not detected in the proximal tubules. (grantome.com)