A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.
PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.
Non-steroidal compounds with estrogenic activity.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.
The formation of a nitrogen-fixing cell mass on PLANT ROOTS following symbiotic infection by nitrogen-fixing bacteria such as RHIZOBIUM or FRANKIA.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
Material prepared from plants.
Freedom of equipment from actual or potential hazards.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
The transference of a kidney from one human or animal to another.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A diet designed to cause an individual to lose weight.
Decrease in existing BODY WEIGHT.
The palm family of order Arecales, subclass Arecidae, class Liliopsida.
Time period from 1901 through 2000 of the common era.
Regular course of eating and drinking adopted by a person or animal.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Compensatory plans designed to motivate physicians in relation to patient referral, physician recruitment, and efficient use of the health facility.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.
Proteins which are present in or isolated from SOYBEANS.
A plant species of the family FABACEAE widely cultivated for ANIMAL FEED.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
Common name for various species of large, vigorous ocean fishes in the family Scombridae.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Societies whose membership is limited to physicians.
The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Societies whose membership is limited to nurses.
A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Databases devoted to knowledge about specific genes and gene products.
Hydrazines substituted with two methyl groups in any position.
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
Genetic loci associated with a QUANTITATIVE TRAIT.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.

Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol. (1/37)

Administration of the phytoestrogen coumestrol to ovariectomized rats leads to increases in both wet and dry uterine weights in the absence of an increase in uterine DNA content, as reported by Markaverich et al. [Effects of Coumestrol on Estrogen Receptor Function and Uterine Growth in Ovariectomized Rats. Environ Health Perspect 103:574-581 (1995)]. It was not possible to know if the observed atypical uterotrophic response of coumestrol was associated uniquely with the ovariectomized uterotrophic assay protocol. This question is answered in the present paper. Two experiments are described in which three daily oral gavage administrations of 60 mg/kg/day coumestrol to immature AP rats were followed by assessment of the reproductive tract on the fourth day. In both experiments coumestrol increased uterine fluid content and increased the weights of the uterus, cervix, and vagina. In addition, bromodeoxyuridine staining of uterine sections enabled confirmation of uterine hyperplasia for the coumestrol-treated animals. In the second experiment, total uterine DNA was determined; it doubled in the coumestrol-treated animals. Estradiol benzoate acted as the positive control agent for both of these experiments, and in each case it gave similar responses to those seen for coumestrol. We conclude that the uterotrophic activity of the phytoestrogen coumestrol in the immature intact rat is typical of the activity of the natural estrogen estradiol.  (+info)

Evaluation of a Tier I screening battery for detecting endocrine-active compounds (EACs) using the positive controls testosterone, coumestrol, progesterone, and RU486. (2/37)

After previously examining 12 compounds with known endocrine activities, we have now evaluated 4 additional compounds in a Tier I screening battery for detecting endocrine-active compounds (EACs): a weak estrogen receptor (ER) agonist (coumestrol; COUM), an androgen receptor (AR) agonist (testosterone; TEST), a progesterone receptor (PR) agonist (progesterone; PROG), and a PR antagonist (mifepristone; RU486). The Tier I battery incorporates 2 short-term in vivo tests (5-day ovariectomized female battery; 15-day intact male battery) and an in vitro yeast transactivation system (YTS). The Tier I battery is designed to identify compounds that have the potential to act as agonists or antagonists to the estrogen, androgen, progesterone, or dopamine receptors; steroid biosynthesis inhibitors (aromatase, 5alpha-reductase, and testosterone biosynthesis); or compounds that alter thyroid function. In addition to the Tier I battery, a 15-day dietary restriction experiment was performed using male rats to assess confounding due to treatment-related decreases in body weight. In the Tier I female battery, TEST administration increased uterine weight, uterine stromal cell proliferation, and altered hormonal concentrations (increased serum testosterone [T] and prolactin [PRL]; and decreased serum FSH and LH). In the male battery, TEST increased accessory sex gland weights, altered hormonal concentrations (increased serum T, dihydrotestosterone [DHT], estradiol [E2], and PRL; decreased serum FSH and LH), and produced microscopic changes of the testis (Leydig cell atrophy and spermatid retention). In the YTS, TEST activated gene transcription in the yeast containing the AR or PR. In the female battery, COUM administration increased uterine weight, uterine stromal cell proliferation, and uterine epithelial cell height, and increased serum PRL concentrations. In the male battery, COUM altered hormonal concentrations (decreased serum T, DHT, E2; increased serum PRL) and, in the YTS, COUM activated gene transcription in the yeast containing the ER. In the female battery, PROG administration increased uterine weight, uterine stromal cell proliferation, and uterine epithelial cell height and altered hormonal concentrations (increased serum progesterone and decreased serum FSH and LH). In the male battery, PROG decreased epididymis and accessory sex gland weights, altered hormonal concentrations (decreased serum T, PRL, FSH, and LH; increased serum progesterone and E2), and produced microscopic changes of the testis (Leydig cell atrophy). In the YTS, PROG activated gene transcription in the yeast containing the AR or PR. In the female battery, RU486 administration increased uterine weight and decreased uterine stromal cell proliferation. In the male battery, RU486 decreased epididymis and accessory sex gland weights and increased serum FSH and LH concentrations. In the YTS, RU486 activated gene transcription in the yeast containing the ER, AR, or PR. Dietary restriction data demonstrate that confounding due to decrements in body weight are not observed when body weight decrements are 10% or less in the Tier I male battery. In addition, minimal confounding is observed at body decrements of 15% (relative liver weight, T3, and T4). Hence, compounds can be evaluated in this Tier I at levels that produce a 10% decrease in body weight without confounding of the selected endpoints. Using the responses obtained for all the endpoints in the Tier I battery, a distinct "fingerprint" was produced for each type of endocrine activity against which compounds with unknown activity can be compared. These data demonstrate that the described Tier I battery is useful for identifying EACs and they extend the compounds evaluated to 16.  (+info)

Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays. (3/37)

Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding increases in uterine epithelial cell height, glandular formation, cell labeling, and DNA content. These papers did not answer the question of whether there is a basic difference between the ovariectomized and the intact rat uterotrophic assays. In this paper, we report that coumestrol gives a typical estradiol-type uterotrophic response in uterotrophic assays using immature intact, immature ovariectomized, and mature ovariectomized rats. We concluded that the uterotrophic activity of coumestrol is typical of the natural estrogen estradiol.  (+info)

Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay. (4/37)

The cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) have numerous industrial and consumer applications and thus have the potential for human exposure. The present study was undertaken to examine potential estrogenic and antiestrogenic activities of D4 and HMDS. To address potential differences in sensitivity between rat strains the study used both Sprague-Dawley (SD) and Fischer 344 (F-344) rats. Estrogenicity of the test compounds was determined by measuring absolute and relative uterine weights in immature rats and by monitoring uterine epithelial cell height. In order to place the data obtained for D4 into perspective relative to strong and weak estrogenic compounds, the response produced by D4 at 0, 10, 50, 100, 250, 500, and 1000 mg/kg/day was compared to responses produced by ethinyl estradiol (EE) (1, 3, 10, or 30 microg/kg/day), diethylstilbestrol dipropionate (DES-DP) (0.5, 1.5, 5, 15 microg/kg/day), and coumestrol (CE) (10, 35, 75, 150 mg/kg/day). Antiestrogenic effects were evaluated by co-administering D4 (500 mg/kg/day) with EE at 1, 3, 10, and 30 microg /kg/day. All compounds were administered in sesame oil at a volume of 5 mL/kg by oral gavage. Beginning on postnatal day 18 (SD) or 21 (F-344) each pup (12 per group) received a single dose of test compound once a day for 4 consecutive days. The pups were euthanized the morning after the last treatment and their uteri removed, weighed, and processed for histological examination. EE and DES-DP produced a significant dose-dependent increase in absolute and relative uterine weights and uterine cell height. The maximum increase in uterine weight following EE exposure was approximately 350% relative to controls in both strains. The weak phytoestrogen CE also produced a dose-related increase in absolute and relative uterine weight and epithelial cell height, but the response occurred over a much higher range of doses. At the highest dose of CE, uterine weight was increased approximately 230% relative to controls. Following exposure to D4, absolute and relative uterine weights and uterine epithelial cell height were statistically significantly increased in both strains of rats at doses above 100 mg/kg/day. In terms of uterine weight, D4 was approximately 0.6 million times less potent than EE or DES-DP in SD pups and 3.8 million times less potent than EE or DES-DP in F-344 pups. The maximal increase in uterine weight, relative to controls, produced by D4 at 1000 mg/kg/day was approximately 160% in SD rats, while the maximum increase produced by D4 in F-344 rats was 86%. D4 co-administered over a wide range of EE doses, resulted in a significant reduction in uterine weight compared to EE alone. HMDS was evaluated in SD rats only. The response produced by HMDS (600 and 1200 mg/kg/day) was compared to EE (3 microg/kg/day). Antiestrogenic effects were evaluated by co-administering HMDS (1200 mg/kg/day) with EE at 3 microg/kg/day. HMDS had no measurable effect on uterine weight under the experimental conditions described here. However, HMDS coadministered with EE did produce a small, but statistically significant reduction in uterine weight compared to EE alone. In conclusion, D4 showed weak estrogenic and antiestrogenic activity that was several orders of magnitude less potent than EE, and many times less potent than the weak phytoestrogen CE.  (+info)

Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure. (5/37)

We examined the effects of maternal exposure to estrogens on platelet-derived growth factor (PDGF) receptor (PDGFR) expression in newborn rat testis. Pregnant rats were treated from gestation Day 14 to birth with corn oil containing diethylstilbestrol, bisphenol A, genistein, or coumestrol by gavage or subcutaneous injection. These treatments induced a dose-dependent increase in the expression of PDGFR alpha and beta mRNAs, determined by semiquantitative reverse transcription polymerase chain reaction, though diethylstilbestrol had a biphasic effect on both mRNAs. In situ hybridization analysis showed that PDGFRalpha mRNA increased mostly in the interstitium, while PDGFRbeta mRNA increased both in the interstitium and seminiferous cords. Immunohistochemical studies of PDGFRalpha and beta proteins revealed that both receptors were present in testis before and after birth and that they were upregulated upon treatment with estrogens in 3-day-old rats, with PDGFRbeta increasing dramatically in gonocytes. PDGFRalpha and beta mRNAs and proteins were also found in purified gonocytes. Our previous finding that PDGF and 17beta-estradiol induce gonocyte proliferation in vitro, together with the present finding that in vivo exposure to estrogens upregulates PDGF receptors in testis, suggest that PDGF pathway is a target of estrogens in testis. In addition, these data identify PDGFRbeta in gonocytes as a major target of gestational estrogen exposure, suggesting that estrogen may have a physiological interaction with PDGF during gonocyte development. These results, however, do not exclude the possibility that the effects of the compounds examined in this study might be due to estrogen receptor-independent action(s).  (+info)

The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses. (6/37)

Many commercial laboratory diets have detectable levels of isoflavones (e.g., phytoestrogens such as genistein [GN]) that have weak estrogenic activity both in vitro and in vivo. During validation studies of the uterotrophic bioassay, diet samples from 20 participating laboratories were collected and analyzed for three major phytoestrogens: GN, daidzein (DN), and coumestrol (CM). Soy phytoestrogens GN and DN were found at total phytoestrogen levels from 100 to 540 microg/g laboratory diet; a forage phytoestrogen, CM, ranged from nondetectable to 4 microg/g laboratory diet. The phytoestrogen levels were compared with both baseline uterine weights of the control groups and with the relative uterine weight increase of groups administered two weak estrogen agonists: bisphenol A (BPA) and nonylphenol (NP). The comparison uses a working assumption of additivity among the phytoestrogens, despite several significant qualifications to this assumption, to estimate total genistein equivalents (TGE). Some evidence was found that phytoestrogen levels in the diet > 325-350 microg/g TGE could diminish the responsiveness of the uterotrophic bioassay to weak agonists. This was especially true for the case of the intact, immature female version of the uterotrophic bioassay, where higher food consumption relative to body weight leads to higher intakes of dietary phytoestrogens versus ovariectomized adults. This dietary level is sufficient in the immature female to approach a biological lowest observable effect level for GN of 40-50 mg/kg/day. These same data, however, show that low to moderate levels of dietary phytoestrogens do not substantially affect the responsiveness of the assay with weak estrogen receptor agonists such as NP and BPA. Therefore, laboratories conducting the uterotrophic bioassay for either research or regulatory purposes may routinely use diets containing levels of phytoestrogens < 325-350 microg/g TGE without impairing the responsiveness of the bioassay.  (+info)

Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. (7/37)

Epidemiological studies suggest that post-menopausal hormone replacement therapy (HRT) reduces colorectal cancer (CRC) incidence. Phytoestrogens, including the soy isoflavone genistein and coumestrol, are used by many women as alternatives to HRT. Previous studies showed that ovariectomy induced a 77% increase in intestinal adenoma number in the C57BL/6J-Min/+ (Min/+) mouse, an animal model of adenomatous polyposis coli (APC)-associated CRC. Replacement of estradiol (E(2)) in ovariectomized Min/+ mice reduced tumor number to baseline and up-regulated the expression of estrogen receptor beta (ERbeta). We hypothesized that the phytoestrogens genistein and coumestrol would inhibit intestinal tumorigenesis in ovariectomized Min/+ mice. Min/+ and Apc(+/+) (WT) mice were ovariectomized and assigned to either a control diet or treatment with E(2), genistein or coumestrol. Treatment of ovariectomized Min/+ (Min/+ OX) mice with genistein resulted in a non-significant reduction in tumor number. Min/+ OX mice treated with coumestrol had significantly fewer tumors than untreated Min/+ OX controls and the same number of tumors as non-ovariectomized Min/+ mice. Bromodeoxyuridine migration assays also demonstrated that treatment with E(2) or coumestrol improved enterocyte migration rate. Immunoprecipitation and immunohistochemistry analyses showed that impaired association of the adherens junction proteins E-cadherin and beta-catenin in Min/+ mice was improved by treatment with either E(2) or coumestrol. Immunoblot analyses also showed that expression of ERbeta was elevated in enterocytes of Min/+ OX mice treated with E(2) or coumestrol as compared with those of untreated Min/+ OX mice. In conclusion, both coumestrol and E(2) prevent intestinal tumorigenesis and ameliorate enterocyte migration and intercellular adhesion in the Apc(Min/+) mouse model of CRC.  (+info)

Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells. (8/37)

Xenoestrogens (XEs) are widespread in our environment and are known to have deleterious effects in animal (and perhaps human) populations. Acting as inappropriate estrogens, XEs are thought to interfere with endogenous estrogens such as estradiol (E2) to disrupt normal estrogenic signaling. We investigated the effects of E2 versus several XEs representing organochlorine pesticides (dieldrin, endosulfan, o',p'-dichlorodiphenylethylene), plastics manufacturing by-products/detergents (nonylphenol, bisphenol A), a phytoestrogen (coumestrol), and a synthetic estrogen (diethylstilbestrol) on the pituitary tumor cell subline GH3/B6/F10, previously selected for expression of high levels of membrane estrogen receptor-alpha. Picomolar to nanomolar concentrations of both E2 and XEs caused intracellular Ca2+ changes within 30 sec of administration. Each XE produced a unique temporal pattern of Ca2+ elevation. Removing Ca2+ from the extracellular solution abolished both spontaneous and XE-induced intracellular Ca2+ changes, as did 10 microM nifedipine. This suggests that XEs mediate their actions via voltage-dependent L-type Ca2+ channels in the plasma membrane. None of the Ca2+ fluxes came from intracellular Ca2+ stores. E2 and each XE also caused unique time- and concentration-dependent patterns of prolactin (PRL) secretion that were largely complete within 3 min of administration. PRL secretion was also blocked by nifedipine, demonstrating a correlation between Ca2+ influx and PRL secretion. These data indicate that at very low concentrations, XEs mediate membrane-initiated intracellular CCa2+ increases resulting in PRL secretion via a mechanism similar to that for E2, but with distinct patterns and potencies that could explain their abilities to disrupt endocrine functions.  (+info)

TY - JOUR. T1 - The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced toxicity on mice astrocytes. AU - Liu, Man Hai. AU - Tsuang, Fon Yih. AU - Sheu, Shiow Yunn. AU - Sun, Jui Sheng. AU - Shih, Chi Ming. PY - 2011/7. Y1 - 2011/7. N2 - Objectives: Estrogen replacement therapy can decrease the risk of developing Alzheimers disease. Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes. Methods: Different concentrations of coumestrol were tested for their protective efficacy against two toxic insults, lipopolysaccharide (LPS) and amyloid-beta peptide, on astrocytes. The mitochondrial activity of astrocytes was determined, and the protective efficacy and pathway were examined by their specific gene expression and protein change. Results: The results showed that coumestrol induced a modest but significant ...
Ovariectomized rats were pretreated with intravenous estradiol-17 beta (E2), coumestrol or genistein and were challenged 2 h later with GnRH (50 ng/kg BW, i.v.). Blood samples, drawn at the time of GnRH administration and 15 min afterwards, were assayed for luteinizing hormone (LH). While low-dose E2 pretreatment (10 ng/kg BW) significantly enhanced GnRH-induced LH release,
We recently showed that two different ALDH+ and CD44+/CD24-/low breast cancer stem cells (BSCSs) exhibited stem cell characteristics that include self-renewal, extensive proliferation, the ability to form non-adherent spherical clusters, chemotherapy resistance and high Notch1 expression. We have identified a compound compound: 6-(3-methylbut-2-enyl) coumestrol (Pso) and treatment with Pso resulted in growth inhibition and an EMT phenotype in both BCSCs and BC cells. Oral Pso administration at physiologically achievable doses (25 mg/kg/BW) suppressed the growth of BCSCs and BC xenografts without toxicity. In the current studies, we identified several novel Pso-derived analogs that may be more potent than the parent compound. One such compound, 1-methoxyphaseollidin (1MP), obtained via three main functional group changes: (i) translocation of the isoprenyl moiety from the phenyl ring fused to the pyran ring (as in Pso) to the phenyl ring adjacent to the furan ring, (ii) removal of the carbonyl ...
We are all fans of greens blended in smoothies, but they are also excellent when blended for a soup! This is a very thick but nourishing and light soup that combines so many nutrient-dense greens! Peas are high in fiber at 9g per cup and protein at 8g per cup which makes it a great food for healthy weight control. This soup is full of chlorophyll and rich with important micronutrients such as Vitamin K, manganese, iron, calcium, Vitamin B and Vitamin C. Peas are also high in antioxidants, one called coumestrol that has been shown to protect against stomach cancer ...
Sigma-Aldrich offers abstracts and full-text articles by [Chris Talsness, Konstanze Grote, Sergio Kuriyama, Kenia Presibella, Anja Sterner-Kock, Katia Poça, Ibrahim Chahoud].
Aims: Development of urinary incontinence, for many women, occurs following menopause. Dietary phytoestrogens consumed over the long term may affect the contractile function and maintenance of the urinary bladder in post menopausal women. This study examined the muscarinic receptor mediated contractile responses in the rat isolated bladder in response to ovariectomy and long term dietary phytoestrogen consumption. Main methods: Ovariectomised or sham-operated female Wistar rats (8 weeks) were fed either normal rat chow (soy, phytoestrogens) or a non-soy (phytoestrogen free) diet. Bladders were dissected from rats at 12, 24 and 52 weeks of age and placed in 25 ml organ baths filled with McEwans solution. Key findings: The contractile response to carbachol, in 12 week old female rats did not change as a result of dietary phytoestrogens or ovariectomy (PN0.05). At 24 weeks of age, detrusor muscle strip responses to carbachol from non-soy fed ovariectomised rats were attenuated (Pb0.05). At 52 ...
Phytoestrogens have been investigated as natural alternatives to hormone replacement therapy and their potential as chemopreventive agents. We investigated the effects of equol, genistein, and coumestrol on cell growth in fully estrogenized MCF7 cells, simulating the perimenopausal state, and long-term estrogen-deprived MCF7:5C cells, which simulate the postmenopausal state of a woman after years of estrogen deprivation, and compared the effects with that of steroidal estrogens: 17β estradiol (E2) and equilin present in conjugated equine estrogen. Steroidal and phytoestrogens induce proliferation of MCF7 cells at physiologic concentrations but inhibit the growth and induce apoptosis of MCF7:5C cells. Although steroidal and phytoestrogens induce estrogen-responsive genes, their antiproliferative and apoptotic effects are mediated through the estrogen receptor. Knockdown of ERα using siRNA blocks all estrogen-induced apoptosis and growth inhibition. Phytoestrogens induce endoplasmic reticulum ...
Dietary phytoestrogens present in soy dramatically increase cardiotoxicity in male mice receiving a chemotherapeutic tyrosine kinase inhibitor Journal Article ...
The new bone health nutrient. Potent bone-enhancing benefits are reported for ipriflavone, a type of isoflavone, that works by a non-hormonal mechanism. By inhibiting breakdown of bone, ipriflavone favorably affects bone density. Available separately or as part of our new Osteo-guard Plus Ipriflavone, a more complete bone support formula. Ipriflavone 300 mg. Suggested Usage: 1 capsule twice daily. Category: Flavonoid Antioxidants
Complete osteoporosis support formula, with ipriflavone; reduces the risk of osteoporosis This broad spectrum combination of minerals, vitamins, and herbs is formulated to aid in the formation and strengthening of the skeletal system. It provides highly bioavailable forms of calcium, a mineral essential not only for the maintenance of the functional integrity of the nervous, muscular, and skeletal systems, but also cell membrane and capillary impermeability. This formula also provides substances which nutritionally support and enhance the absorption of calcium and the incorporation of calcium into bone. In addition, it provides nutrients essential to healthy bone structure and formation, the synthesis and strengthening of connective tissue in cartilage and bone, and the formation of elastin. Ipriflavone, an advanced addition to this formula, is a synthetic derivative of naturally occurring isoflavones. It supports healthy bone maintenance by promoting secretion of the hormone calcitonin, and
Dietary phytoestrogen and fiber intake do not appear to prevent vasomotor symptoms (VMS), including hot flashes and night sweats.
Learn more about Ipriflavone at Portsmouth Regional Hospital Uses Principal Proposed Uses Preventing and Treating Osteoporosis ...
Learn more about Ipriflavone at Sky Ridge Medical Center Uses Principal Proposed Uses Preventing and Treating Osteoporosis ...
TY - JOUR. T1 - Dietary phytoestrogens. AU - Kurzer, Mindy S. AU - Xu, Xia. PY - 1997/8/19. Y1 - 1997/8/19. N2 - Broadly defined, phytoestrogens include isoflavones, coumestans, and lignans. A number of these compounds have been identified in fruits, vegetables, and whole grains commonly consumed by humans. Soybeans, clover and alfalfa sprouts, and oilseeds (such as flaxseed) are the most significant dietary sources of isoflavones, coumestans, and lignans, respectively. Studies in humans, animals, and cell culture systems suggest that dietary phytoestrogens play an important role in prevention of menopausal symptoms, osteoporosis, cancer, and heart disease. Proposed mechanisms include estrogenic and antiestrogenic effects, induction of cancer cell differentiation, inhibition of tyrosine kinase and DNA topoisomerase activities, suppression of angiogenesis, and antioxidant effects. Although there currently are no dietary recommendations for individual phytoestrogens, there may be great benefit in ...
Compounds with estrogenic potencies and their adverse effects in surface waters have received much attention. Both anthropogenic and natural compounds contribute to overall estrogenic activity in freshwaters. Recently, estrogenic potencies were also found to be associated with cyanobacteria and their blooms in surface waters. The present study developed and compared the solid phase extraction and LC-MS/MS analytical approaches for determination of phytoestrogens (8 flavonoids - biochanin A, coumestrol, daidzein, equol, formononetin, genistein, naringenin, apigenin - and 5 sterols - ergosterol, β-sitosterol, stigmasterol, campesterol, brassicasterol) and cholesterol in water. The method was used for analyses of samples collected in stagnant water bodies dominated by different cyanobacterial species. Concentrations of individual flavonoids ranged from below the limit of detection to 3.58 ng/L. Sterols were present in higher amounts up to 2.25 μg/L. Biological potencies of these phytoestrogens in vitro
The valuable compounds found in pueraria mirifica, miroestrol and deoxymiroestrol, are different and possess highest estrogenic activity among the known phytoestrogen (natural plant estrogen) plants. It has structural similarity to estradiol of the main human estrogen in women bodies, which can bind the female estrogen receptor at the breast tissues. Other phyto-chemicals are: Isoflavones and groups of phytoestrogens e.g. Genistein, Daidzein, Daizin, Genistin and Coumestrol are usually found in soy plant. The estrogenic activity of miroestrol and deoxymiroestrol (in pueraria mirifica) is much more potent than other soy isoflavones. Isoflavones enriched in pueraria mirifica supports healthy cardio-vascular system, enhances breast and skin appearance, support healthy prostate function and healthy bone structure. Its primarily use is as tonic and preserved feminine longevity; firming and tightening breast, nourishing skin, keeps skin supple, smooth and brilliant, black glittering hair and relieving ...
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Baru Rp 350.000 Royalty Breast up Cream Pembesar Payudara ini diformulasikan khusus untuk memperbesar payudara. Selain itu untuk merawat dan mengencangkan payudara agar padat dan montok. Bagian tubuh ini memiliki peranan penting bagi wanita yaitu untuk menunjang penampilan agar lebih cantik dan seksi. Pembesar Payudara Royalty Breast up Cream yang mengandung bahan alami Ekstrak Pueraria Mirifica. Pueraria Mirifica (juga dikenal sebagai Kwao Krua Putih adalah herbal akar berbonggol alami dan mengandung phytoestrogen alami tingkat tinggi, termasuk miroestrol, deoxymiroestrol, daidzein, genistin, B-sitosterol, stigmasterol, coumestrol, Pueraria, campestrol, mirificoumestan, kwakhurin, dan mirificine. MANFAAT PUERARIA MIRIFICA TERHADAP PAYUDARA : Mengangkat dan mengencangkan kembali payudara dan punggung yang mengendur. Memantapkan kembali lagi bentuk payudara menjadikan lebih padat dan berisi. Memperbesar payudara yang mengalami pertumbuhan yang terhambat. Menjadikan payudara lebih seksi. Mencerahkan
TY - JOUR. T1 - Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity. AU - Choi, Yun Hyeok. AU - Hong, Seong Su. AU - Shin, Yu Su. AU - Hwang, Bang Yeon. AU - Park, So Young. AU - Lee, Dongho. PY - 2010/10. Y1 - 2010/10. N2 - Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED50 values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.. AB - Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the ...
BACKGROUND: The causes of prostate cancer are poorly understood, but genetic factors may be more important than for many other malignancies, and dietary phytoestrogens may be protective. Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms. METHODS: We performed a population-based case-control study in Sweden. All participants reported their phytoestrogen intake and donated a blood sample. We identified four haplotype-tagging single nucleotide polymorphisms (htSNPs) and genotyped these htSNPs in 1314 prostate cancer patients and 782 controls. Odds ratios were estimated by multivariate logistic regression. Interactions between phytoestrogen intake and estrogen receptor-beta SNPs on prostate cancer risk were evaluated considering both multiplicative and additive effect scales. RESULTS: We found a significant multiplicative interaction (P = ...
Ipriflavone is a synthetic isoflavone derivative, which has been suggested to be an inhibitor of bone resorption and a stimulator of osteoblast activity in vitro in cell cultures and in vivo in experimental models of osteoporosis. Preliminary studies, mainly performed in Italy and Japan, suggested that ipriflavone (typical dosage 600 mg/day) is able to prevent bone loss, and some data even suggested that ipriflavone may increase bone mass in postmenopausal women. However, reports of lymphocytopenia in women taking ipriflavone generated concerns regarding the safety of this particular compound. In order to investigate the effect of oral ipriflavone in prevention of postmenopausal bone loss and to assess the safety profile of long-term treatment with ipriflavone in postmenopausal osteoporotic women, a prospective, randomized, placebo-controlled 4-year study was conducted in 474 postmenopausal white women with bone mineral densities below the threshold for a diagnosis of osteoporosis, according to ...
Epidemiological and pathological data suggest that thyroid cancer may well be an estrogen-dependent disease. In the study of the relationship between thyroid cancer risk and dietary phytoestrogens, which can have both estrogenic and antiestrogenic properties, using the present data from a multiethnic population-based case-control study of thyroid cancer conducted in the San Francisco Bay Area. Of 817 cases diagnosed between 1995 and 1998 (1992 and 1998 for Asian women), 608 (74%). Of 793 controls identified through random-digit dialing, 558 (70%) indicated that phytoestrogen consumption was assessed via a food-frequency questionnaire and a newly developed nutrient database. The consumption of traditional and nontraditional soy-based foods and alfalfa sprouts were associated with reduced risk of thyroid cancer. Consumption of western foods with added soy flour or soy protein did not affect risk. Of the seven specific phytoestrogenic compounds examined, the isoflavones, daidzein and genistein ...
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Phytoestrogens are used to treat menopausal vasomotor symptoms and osteoporosis, and to decrease the risk of breast cancer and cardiovascular disease. Learn about side effects, dosages, drug interactions, and more.
The purpose of this study was to examine the effects of phytoestrogens on luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Phytoestrogens are found in soybean based foods. The rats in a previous study were fed varying amounts of phytoestrogens, euthanized, and their pituitaries were preserved for further research, which is what was used in this study. In the previous study there was an increase in spermatogenesis for the low and high phytoestrogen diet group compared to the pre-treatment and medium group. The LH and FSH levels in the pituitaries were measured and the results were then analyzed to see if there was a correlation in LH and FSH levels to the phytoestrogen diet groups. A coomassie stain was done to ensure that the differences that were seen between the groups were because of varying amounts of phytoestrogens and not varying amounts of protein being loaded into the electrophoresis gels. There was no difference measured in any of the phytoestrogen diet groups for LHf3 and LH
In the study to review the sources, metabolism, potencies, and clinical effects of phytoestrogens on humans, posted in PubMed, suggested that phytoestrogens are among the dietary factors affording protection against cancer and heart disease in vegetarians. With this epidemiologic and cell line evidence, intervention studies are now an appropriate consideration to assess the clinical effects of phytoestrogens because of the potentially important health benefits associated with the consumption of foods containing these compounds ...
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a)Scope of section; definitions - (1)Service providers. (i) On or after January 1, 2018 for Tier I carriers and April 1, 2018 for service providers other than Tier I carriers, the hearing aid compatibility requirements of this section apply to providers of digital mobile service in the United States to the extent that they offer terrestrial mobile service that enables two-way real-time voice communications among members of the public or a substantial portion of the public, including both interconnected and non-interconnected VoIP services, and such service is provided over frequencies in the 698 MHz to 6 GHz bands. (ii) Prior to January 1, 2018 for Tier I carriers and April 1, 2018 for service providers other than Tier I carriers, the hearing aid compatibility requirements of this section apply to providers of digital CMRS in the United States to the extent that they offer real-time, two-way switched voice or data service that is interconnected with the public switched network and utilizes an ...
Phytoestrogens occupy estrogen receptor sites, just as a key blank will plug into a lock and not start your car, phytoestrogens do not key or activate...
Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats. 28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7 mg/kg) on day first and received saline for next 13 days. Third group received i.p injection of cisplatin at day one and treated with rutin (75 mg/kg) orally for next 13 days. Fourth group was treated with rutin orally for 13 days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters. Cisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids,
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SY09-03 Phytoestrogens are naturally occurring diphenolic compounds from plants that are structurally similar to the hormone 17β-estradiol. Possible anticarcinogenic effects of these compounds in breast cancer are attributed to their capability to bind to estrogen receptors. However, large-scale epidemiological studies have been limited by difficulties in quantifying phytoestrogen intake. Previous assays for phytoestrogens in biological fluids have analysed for a limited number of analytes and have often suffered from complex, multi-stage sample preparation techniques. Using newly developed GC/MS and LC/MS methods incorporating triply 13C-labelled standards, seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin (O-DMA), equol, enterodiol, and enterolactone), it is now possible to measure urinary and circulating levels of phytoestrogens more accurately 1,2. In the absence of food composition data (although analyses are ongoing for UK foods) either phytoestrogens in either ...
http://ThomasDeLauer.com. 4 Foods That Mess Up Your Hormones. 1. Soy - Specifically Non-Organic. According to the National Institutes of Health, we do not fully understand the health effects of pesticides, but their use is associated with cancer, neurological conditions, and diabetes. (9). Phytoestrogens are found in numerous plants, including legumes, broccoli, beans, and soy products. Studies have found both positive and negative effects of phytoestrogens, so these are not necessarily bad - have been found to inhibit certain types of cancer and improve metabolic parameters (1).. That said, phytoestrogens have a very similar structure to the estrogen found in our bodies. These phytoestrogens both connect to and stimulate estrogen receptors. Case Study. In the Avon Longitudinal Study of Pregnancy and Childhood, it was found that 51 of 7,928 boys born suffered from hypospadias, a conditions where the penis does not work and appears abnormal. It was found that boys born to vegetarian mothers who ...
Because the interaction of phytoestrogens with our hormones and receptors is so complex, the jury is still out on their benefits vs. potential harms. Here I present a detailed discussion of phytoestrogens and their impacts on breast cancer.
Estrogen is a hormone primarily involved in the development, maturation and function of the female reproductive system. Phytoestrogens are natural...
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This is a Phase 2b double-blind, randomized, placebo-controlled parallel-group study evaluating the safety and efficacy of arimoclomol (400 mg t.i.d.) compared to placebo. A safety lead-in phase will be employed to ensure the safety of all study volunteers.. Tier I (Safety Lead-in): During the enrollment period for the safety lead-in phase, 24 volunteers meeting inclusion/exclusion criteria will be randomized at 4 investigative sites. These volunteers will have weekly visits during the first 4 weeks after starting treatment. Pharmacokinetics (PK) will be performed at various timepoints throughout these 4 weeks. After the initial 4 weeks of treatment, visits will continue at 4-week intervals up to Week 36, subsequently visits will occur every 8 weeks up to Week 68. A final visit will occur at Week 72. There will be a 28-day post study medication Follow-Up Telephone Call to assess medical status and adverse events.. Tier II: After the Tier I volunteers finish 4 weeks of treatment, their data will ...
Doctors help you with trusted information about Fibroids in Fibroid: Dr. Derman on fibroids uterine growth pregnancy: Only in very rare instances can fibroids be cancerous. If there is very rapid growth in the size, these are the ones that could be a leiomyosarcomas but again very rare.
EPA proposed adding parent company information and e-mail addresses to the Emergency and Hazardous Chemical Inventory Forms (Tier I and Tier II) under Section 312 of the Emergency Planning and Community Right-to-Know Act.
The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a… Expand ...
Ever wanted to create your own custom ROM but dont have enough coding experience to actually get started? Luckily, XDA Senior Moderator Dsixda has created a wonderful kitchen for HTC Android devices that should fulfill all of your ROM baking needs. This kitchen is compatible with both Linux and Mac OS X, so if youre running Windows, you will need to use either Cygwin or a virtualization technology such as VirtualBox. Details for getting either of those solutions are available in the Kitchen FAQ.. According to the developer, this kitchen is targeted towards:. ...
Phytoestrogens are diphenolic, non steroidal compounds which are present in plants and are consumed by both humans and animals. Previous investigations have demonstrated that dietary phytoestrogens appear to have neurobehavioral effects on intermale aggression in male Syrian hamsters and the neural mechanisms require further exploration. In this study experiments involving a phytoestrogen (PE) and a phytoestrogen free (PE Free) diet were performed to determine whether or not diet had an effect on the expression of a and p estrogen receptors in the brain of male Syrian hamsters (Mesocricetus auratus). Twenty male hamsters were used for experimentation and animals were divided into a PE (n = 10) and a PE Free group (n = 10) for a period of 3 weeks. Animals were sacrificed, perfused and brains removed for subsequent protein extraction and immunohistochemisty. Estrogen receptors were quantified using western blot utilizing brains from both the PE and the PE Free group. Results revealed a wide spread
The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. A Swedish nationwide population-based case-control study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Participants in the highest quartile of intake of lignans ...
Nutritionists, dieticians and naturopathic doctors have bought into the claims that soy, soy milk, etc. add safe levels of natural plant-based estrogen which can help menopausal women prevent osteoporosis and other hormone-related ailments. The ingredient in soy which can do these alleged magical things is a substance called isoflavones. Since most isoflavones come from genetically modified soy, they are definitely not natural. Secondly, the increase in estrogen levels by soy isoflavones may be pathological and have never been studied. For instance, infants taking soy have sometimes shown phytoestrogen levels that are 13,000 times higher than normal blood estrogen levels! High levels of some estrogens can promote tumors in various organs, menstrual disruption and sex organ malfunction ...
There seems to be a common misconception in the natural health community that women with high estrogen levels should take phytoestrogen (plant estrogen) because phytoestrogens are protective estrogens which reduce estrogenic activity. It is believed that phytoestrogens compete with endogenous estrogens for estrogen receptors. When the estrogen receptors are occupied by phytoestrogens, cell divisions are reduced because phytoestrogens are weak estrogens. This theory made sense to me until my own experience showed otherwise. With my endometriosis, my pain level was a measurement for my condition. When I tried Don Quei, Licorice, Ginseng and Royal Jelly, I did feel better initially for a few weeks because they helped my blood circulation. As I continued to take these remedies, my pain would come back with a vengeance, more severe than before. I realized that weak estrogens could add up significantly if given enough time. I believe that many women are misled by initial feelings of wellness ...
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The once thriving captive-born southern white rhinoceros population is being threatened by their diet, according to new research. San Diego Zoo Global researchers predict that phytoestrogens in the rhinoceros´ food may be causing reproductive failure in the females.. In a press release detailing the research, Christopher Tubbs, researcher with the San Diego Zoo Institute for Conservation Research explained the importance of the study.. Understanding why the captive white rhinoceros population has been dwindling for decades is an important part of protecting the future of this species. Our work is the first step toward determining if phytoestrogens are involved in this phenomenon and whether we need to reevaluate captive white rhino diets.. Zoologists have only recently found the northern and southern white rhinoceros to be different species´ rather than a subspecies of the African white rhinoceros. As such, conservation efforts have been specifically designed to increase the population of ...
Learn more about Estrogen at Doctors Hospital of Augusta Folate -Supplementation Possibly Helpful Ipriflavone -...
Learn more about Estrogen at Doctors Hospital of Augusta Folate -Supplementation Possibly Helpful Ipriflavone -...
Buy ESTROLOGIC - 60 caps Online.ESTROLOGIC is a special formula that contains extracts of plants rich in phytoestrogens or isoflavones, with which the organism will maintain the balance of oestrogen levels and help with the prevention
Scandium triflate is an effective pre-catalyst for the deoxygenative allylation of benzylic alcohols with a narrow substrate window. The reaction is shown to proceed through a
Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity than 17α ... Coumestans, including coumestrol, a phytoestrogen, are found in a variety of plants. Food sources high in coumestans include ... Coumestrol Wedelolactone Plicadin Singh, Rishi Pal; Singh, Daljeet (1985). "An elegant synthesis of 6H-benzofuro[3,2-c][1] ... Yao, Tuanli; Yue, Dawei; Larock, Richard C (2005). "An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and ...
Red clover contains coumestrol, a phytoestrogen. Due to its activity on oestrogen receptors, red clover is contraindicated in ...
Coumestrol, an isoflavone coumarin derivative, is the only coumestan in foods. Saponins, a class of natural surfactants (soaps ...
Coumestrol levels in alfalfa have been shown to be elevated by fungal infection, but not significantly under drought stress or ... Coumestrol levels in unirrigated crops can be predicted practically using weather variables. Raw alfalfa seeds and sprouts are ... Coumestrol content of lucerne under drought stress, Proceedings of the 18th Australian Society of Agronomy Conference, Ballarat ... Grazing management can be utilised to mitigate the effects of coumestrol on ewe reproductive performance, with full recovery ...
In plants which produce the phytoestrogen coumestrol, such as alfalfa, damage by aphids is linked with higher concentrations of ... Studies on the Chemical and Biological Properties of Coumestrol and Related Compounds. US Government Printing Office. pp. 47-67 ... coumestrol. The coating of plants with honeydew can contribute to the spread of fungi which can damage plants. Honeydew ...
Structurally, psoralidin is a coumestan derivative; it has an isopentenyl group at the second carbon position of coumestrol. ...
... coumestrol, daidzein, genistein, miroestrol). Those produced by fungi are known as mycoestrogens (e.g., zearalenone). Estrogens ...
Isoflavanes Isoflavandiols Isoflavenes Pterocarpans or Coumestans (phytoestrogens) Coumestrol red clover, alfalfa sprouts, soy ...
Evidence does not support a benefit from phytoestrogens such as coumestrol, femarelle, or the non-phytoestrogen black cohosh. ...
... s have also been shown to contain the phytoestrogen coumestrol, which has a variety of possible health effects. Gallo ...
... coumestrol, kwakhurin, and mirificine, β-sitosterol, stigmasterol, campesterol, and mirificoumestan.[citation needed] There is ...
... anhydrovariabilin and coumestrol dimethyl ether. "The Plant List". Hyde, M. A.; Wursten, B. T.; Ballings, P.; Coates Palgrave, ...
... coumestrol, daidzein, deoxymiroestrol, equol, genistein, miroestrol, many others Selective estrogen receptor modulator ...
... coumestrol MeSH D03.438.150.266.450.400.375 - genistein MeSH D03.438.150.266.450.400.687 - pterocarpans MeSH D03.438.150.266. ... coumestrol MeSH D03.830.219.266.450.400.375 - genistein MeSH D03.830.219.266.450.400.687 - pterocarpans MeSH D03.830.219.266. ... coumestrol MeSH D03.438.150.446.400 - esculin MeSH D03.438.150.446.520 - 4-hydroxycoumarins MeSH D03.438.150.446.520.079 - ... coumestrol MeSH D03.830.219.446.400 - esculin MeSH D03.830.219.446.520 - 4-hydroxycoumarins MeSH D03.830.219.446.520.079 - ...
... coumestrol, daidzein, genistein, miroestrol) Selective estrogen receptor modulators (e.g., tamoxifen, clomifene, raloxifene) ...
... coumestrol - CP-358,774 - CP-609,754 - CP-724,714 - CP4071 - CpG 7909 - CPT 11 - CQS - craniopharyngioma - craniotomy - ...
... that both deoxymiroestrol and miroestrol were comparable in activity in vitro to other known phytoestrogens such as coumestrol ...
... has been shown to accelerate the onset of puberty in mice. Exposure to coumestrol immediately after birth resulted ... Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. Coumestrol was first identified as ... Levels of coumestrol within individual plants of the same species are variable. Studies of coumestrol levels in alfalfa suggest ... The highest concentrations of coumestrol are found in clover, Kala Chana, a type of chick pea, and Alfalfa sprouts. Coumestrol ...
Coumestans (e.g., coumestrol, psoralidin). *Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, ...
Coumestans (e.g., coumestrol, psoralidin). *Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, ... Plant products with estrogenic activity are called phytoestrogens (e.g., coumestrol, daidzein, genistein, miroestrol). ...
Coumestans (e.g., coumestrol, psoralidin). *Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, ...
Coumestans (e.g., coumestrol, psoralidin). *Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, ...
Coumestrol, an isoflavone coumarin derivative, is the only coumestan in foods.[175][176] ...
Coumestrol, an isoflavone coumarin derivative, is the only coumestan in foods.[43][44] ...
Coumestrol has been shown to accelerate the onset of puberty in mice. Exposure to coumestrol immediately after birth resulted ... Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. Coumestrol was first identified as ... Levels of coumestrol within individual plants of the same species are variable. Studies of coumestrol levels in alfalfa suggest ... The highest concentrations of coumestrol are found in clover, Kala Chana, a type of chick pea, and Alfalfa sprouts. Coumestrol ...
This topic has 1 study abstract on Coumestrol indicating that it may have therapeutic value in the treatment of Lupus ... Coumestrol from the national cancer Institutes natural product library is a novel inhibitor of protein kinase CK2.Jul 10, 2013 ... Coumestrol suppresses the accumulation of HIF-1α via suppression of SPHK1 pathway in hypoxic prostate cancer cells.May 31, 2014 ... Coumestrol treatment has potential benefits for either prevention or therapeutics use against cerebral ischemia in males.Feb 28 ...
High-performance liquid chromatographic assay of isoflavonoids and coumestrol from human urine.. Franke AA1, Custer LJ. ... and of coumestrol, another commonly occurring phytoestrogen. Analytes were isolated and concentrated by solid-phase extraction ... and separated by HPLC followed by identification through retention times and UV scans, and in the case of coumestrol ...
Male rats were injected either with 100 μg coumestrol or DMSO... ... Coumestrol had no effect on weights of testes and sex accessory ... Whereas steady state levels of LHβ mRNA in coumestrol-treated rats did not differ from those of controls, steady state levels ... Male rats were injected either with 100 μg coumestrol or DMSO (controls) daily during their first 5 d of life. Pituitary gland ... Neonatal exposure to coumestrol, a phytoestrogen, does not alter spermatogenic potential in rats. ...
These findings suggest that the anti-cancer effect of coumestrol is due to the direct targeting of haspin kinase. Coumestrol ... Haspin kinase was identified as a direct target protein of coumestrol using kinase profiling analysis. Histone H3 is a direct ... In the present study, we investigated coumestrol, a natural compound exhibiting broad anti-cancer effects against skin melanoma ... Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. Jong-Eun Kim 1 ...
Pea aphids had a minor effect on coumestrol content. When alfalfa was subjected to ~5 aphids per stem for 4 wk coumestrol ... Alfalfa coumestrol content in response to development stage, fungi, aphids, and cultivar. Fields, Rachel; Barrell, Graham K.; ... all reached coumestrol levels reported to pose a risk to ewe reproductive performance (,25 mg kg⁻¹ DM). In S. vesicarium- ... Coumestrol produced by alfalfa (Medicago sativa L.) can reduce the ovulation rate of ewes. This study isolated agronomic ...
Clandestine Coumestrol. Clover and soybean sprouts are highest in a phytoestrogen called coumestrol, a coumestan that can bind ... Brussels sprouts and spinach also contain coumestrol at a lower level, according to researchers of the 2007 mini review ...
Table of Substrates, Inhibitors and Inducers (including: CYP Enzymes, Clinical index drugs, transporters, and examples of clinical substrates, inhibitors, and inducers).
... coumestrol, n = 3; prunetin, n = 1), and the androgen trans-androsterone (n = 1). The poisson GLM indicated that the number of ... coumestrol, daidzein, formononetin, prunetin, and glycitein), and sterols (cholesterol, dihydrocholesterol, and 3β-coprostanol ... coumestrol, daidzein, formononetin, and prunetin) detected, total organic EDCs detected (classical estrogens + phytoestrogens ...
... coumestrol, ICI-164384 , 17 beta-estradiol , estrone, genistein , estriol , nafoxidine, 5-androstene-3 beta, 17 beta-diol , 17 ... coumestrol, ICI-164384 , estrone, 17 alpha-estradiol , nafoxidine, moxestrol , clomifene , estriol, 4-OH-estradiol , tamoxifen ...
Tahara 1987 coumestrolIngham 1988 mirificin, and 2 steroids, estrone and estriol.Sookvanichsilp 2008, Ingham 1986, Ingham 1989 ... coumestrol; genistein/equol; daidzein; resveratrol.Matsumura 2005P. mirifica also had an estrogenic effect on a human HepG2 ...
Coumestrol (CM), a phytoestrogen, and tetrachlorodioxin (TCDD) in concentrations of 10-4 to 10-6M significantly inhibited ... coumestrol and BPA are shown in Figure 3. 17-β-estradiol and coumestrol had significant cell cycle phase effect on actively ... Lower concentrations of coumestrol in long term exposure show increased cell accumulation in S phase and G2M (G2M shift from 10 ... Figure 7. RT-PCR of bcl-2 and p53 total Jurkat T cell RNA after 24 hours exposure to 10-6M 17-β-estradiol (E), coumestrol (CM ...
The science is complex, but imagine tiny messengers landing on a plant leaf in a light mist of water to hold urgent face-to-face meetings with the receptionists waiting on the plants surface.. Their news is so important, the receptionists signal the plants cells, then the whole plant sits up and takes note. It rapidly produces the essential oils needed to gets all its parts moving and swings into action. It marshals its defence forces, repairs breaches in the walls, and builds strength and vigour. If theres an attack, the plant is ready to go to war. If theres not, it is strongly motivated to become the best it can be. ...
Coumestrol Explained. Leave a Comment WHAT IS COUMESTROL? Coumestrol is a coumestan which is part of the phytonutrient (a group ... In this article I will be providing a full breakdown of coumestrol. WHEN WAS COUMESTROL DISCOVERED? Coumestrol was first ... Filed Under: Coumestans Tagged With: antioxidants, coumestans, coumestrol, flavonoids, phenolic compounds, phytochemicals, ... Coumestans (which include coumestrol). - Flavanones (which include hesperidin, naringenin and silymarin). - … [Read more...] ...
Coumestrol Explained. Leave a Comment WHAT IS COUMESTROL? Coumestrol is a coumestan which is part of the phytonutrient (a group ... In this article I will be providing a full breakdown of coumestrol. WHEN WAS COUMESTROL DISCOVERED? Coumestrol was first ... Filed Under: Coumestans Tagged With: antioxidants, coumestans, coumestrol, flavonoids, phenolic compounds, phytochemicals, ... There is relatively little information available on coumestrol although it is believed to have strong cancer fighting ...
The addition of coumestrol could reverse the toxic effect induced by LPS and amyloid-beta peptide. Both the LPS and amyloid- ... The addition of coumestrol could reverse the toxic effect induced by LPS and amyloid-beta peptide. Both the LPS and amyloid- ... The addition of coumestrol could reverse the toxic effect induced by LPS and amyloid-beta peptide. Both the LPS and amyloid- ... The addition of coumestrol could reverse the toxic effect induced by LPS and amyloid-beta peptide. Both the LPS and amyloid- ...
In the investigation in vitro of protective effects of coumestrol on mice astrocytes, found that coumestrol induced a modest ... In the investigation of the effects of coumestrol on osteoblasts and osteoclasts, inducated that phytoestrogen coumestrol has a ... but coumestrol had little effect on intestinal ALP activity at 10 days after parturition, according to "Effects of coumestrol ... M coumestrol, according to "The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced ...
Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.Aug 15, 2016 ...
... coumestrol for 4%, and the lignans for 2%. The primary sources of phytoestrogens were tofu (47%), soy milk (22%), and foods ... coumestrol; and the lignans: matairesinol and secoisolariciresinol. ...
... coumestrol for 4%, and the lignans for 2%. The primary sources of phytoestrogens were tofu (47%), soy milk (22%), and foods ... coumestrol; and the lignans: matairesinol and secoisolariciresinol. ...
Additionally, coumestrol and genistein induced apoptosis in MECs. These results indicate that phytoestrogens weaken the blood- ... The results showed that coumestrol and genistein changed the expression of TJ proteins (claudins-3 and -4 and occludin), ... Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, and daidzein) by using an in vitro mouse-MEC ... 0 (Caseins); 0 (Isoflavones); 0 (Phytoestrogens); 6287WC5J2L (daidzein); DH2M523P0H (Genistein); V7NW98OB34 (Coumestrol). ...
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model. ...
Medicago 10% Coumestrol Milk Thistle 80% Silymarin (HPLC) Morinda Root 4:1 Extract Motherwort 5:1 Extract Moutan Bark 20:1 ...
Zimmermann, M., Tilghman, S.L., Boue, S.M., Salvo, V.A., Elliott, S., Williams, K., Skripnikova, E.V., Ashe, H., Payton-Stewart, F., Vanhoy-Rhodes, L., Fonseca, J., Corbitt, C., Collins-Burow, B.M., Howell, M.H., Lacey, M., Shih, B.Y., Carter Wientjes, C.H., Cleveland, T.E., Mclachlan, J.A., Wiese, T.E., Beckman, B.S., Burow, M.E. 2010. Glyceollin I, A Novel Antiestrogenic Phytoalexin Isolated from Activated Soy. Journal of Pharmacology and Experimental Therapeutics. 332(1):35-45 ...
Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity than 17α ... Coumestans, including coumestrol, a phytoestrogen, are found in a variety of plants. Food sources high in coumestans include ... Coumestrol Wedelolactone Plicadin Singh, Rishi Pal; Singh, Daljeet (1985). "An elegant synthesis of 6H-benzofuro[3,2-c][1] ... Yao, Tuanli; Yue, Dawei; Larock, Richard C (2005). "An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and ...
coumestrol decreases expression. ISO. RGD:1323243. 6480464. Coumestrol results in decreased expression of TLNRD1 mRNA. CTD. ...
coumestrol multiple interactions. EXP. 6480464. [Coumestrol co-treated with resveratrol] results in increased expression of VXN ... Coumestrol co-treated with resveratrol] results in increased expression of VXN mRNA. CTD. PMID:19167446. ...
Based on in vitro (Table 1) and in vivo (Table 2) relative potency values for coumestrol, equol, and genistein, and ... 1997). Prepubertal CFLP mice; SQ injection; DES doses of 0.5, 5, 50 ng; coumestrol doses of 1, 10, 100 μg ... and coumestrol (Table 1), which are thought to be responsible for any potential estrogenic health effects, to the extent that ... coumestrol, genistein, zearalenol, and zearalenone have potencies just below that range. The cyclic siloxane ...
Study BM -1 adaptogens flashcards from jennifer davidson
  • Coumestrol is a phytoestrogen, mimicking the biological activity of estrogens. (wikipedia.org)
  • Although, due to the variability of the human diet, the exact amount of coumestrol the average person consumes has not been calculated, studies of phytoestrogen intake suggest that most human diets result in a negligible intake of coumestrol relative to the maximum tolerable daily intake. (wikipedia.org)
  • The phytoestrogen coumestrol decreases autoantibodies in a mouse model of systemic lupus. (greenmedinfo.com)
  • A rapid, sensitive and precise diode-array reversed-phase HPLC method was developed for human urine analysis of the most common dietary isoflavones daidzein, genistein, formononetin and biochanin-A, their mammalian metabolites equol and O-desmethylangolensin, and of coumestrol, another commonly occurring phytoestrogen. (nih.gov)
  • Clover and soybean sprouts are highest in a phytoestrogen called coumestrol, a coumestan that can bind to estrogen receptors. (livestrong.com)
  • Coumestrol (CM), a phytoestrogen, and tetrachlorodioxin (TCDD) in concentrations of 10 -4 to 10 -6 M significantly inhibited Jurkat T cell lymphoproliferation, whereas bisphenol A (BPA) and DDT had minimal effect, but did antagonize 17-β-estrtadiol induced effects. (mdpi.com)
  • Representative xenoestrogens include compounds such as coumestrol, a phytoestrogen found in high levels in legumes that acts as an estrogen agonist. (mdpi.com)
  • In the evaluation of Endogenous estrogens dramatic and differential effects on classical endocrine organ and proliferation, found that Using human cervical cancer cells (HeLa cells) as a model, the effects of representative xenoestrogens ( Coumestrol -a phytoestrogen, tetrachlorodioxin (TCDD)-a herbicide and DDT-a pesticide) on proliferation, cell cycle, and apoptosis were examined. (blogspot.com)
  • Alfalfa contains coumestrol , a phytoestrogen which mimics the estrogen in our body. (natural-homeremedies.com)
  • Chansakaow 2000 The tuberous roots of P. mirifica also contain daidzin, daidzein, genistin, genistein, puerarin Ingham 1986 mirificoumestan, kwakhurin Ingham 1986 , Tahara 1987 coumestrol Ingham 1988 mirificin, and 2 steroids, estrone and estriol. (drugs.com)
  • Therefore, we investigated the influence of phytoestrogens (coumestrol, genistein, and daidzein) by using an in vitro mouse-MEC-culture model. (bireme.br)
  • The results showed that coumestrol and genistein changed the expression of TJ proteins (claudins-3 and -4 and occludin), weakened barrier function, and reduced -casein production. (bireme.br)
  • Additionally, coumestrol and genistein induced apoptosis in MECs. (bireme.br)
  • Coumestrol induces transcription as strongly as genistein. (go.jp)
  • Coumestrol, genistein, naringenin and 8-prenylnaringenin were estrogenic and acted additively, while the plant sterols failed to show any effect. (springer.com)
  • The oestrogenic activity of 8-prenyl-naringenin in vitro was greater than that of established phyto-oestrogens such as coumestrol, genistein and daidzein. (bellaonline.com)
  • Previous studies have shown adverse effects on sexual dimorphic development in rat pups treated parenterally with the phytoestrogens genistein and coumestrol during the prenatal and neonatal intervals. (epa.gov)
  • The non-steroidal phyto-oestrogens, coumestrol and genistein, were able to compete with oestradiol-17β (Oe 2 ) for binding sites on a macromolecular component of the uterine cytosol from 6-day-pregnant rabbits. (bioscientifica.com)
  • Binding affinity for these compounds was related to their reported oestrogenic potency: approximately one part by weight of Oe 2 , seventy of coumestrol and 175 of genistein produced equivalent inhibition of the uptake in vitro of [ 3 H]Oe 2 by this uterine receptor. (bioscientifica.com)
  • Its useful range is 0·5 to 40 ng for coumestrol and 2·5 to 200 ng for genistein. (bioscientifica.com)
  • Controls reported consuming higher amounts of foods containing genistein, daidzein, and coumestrol and lower amounts of foods containing campesterol and stigmasterol. (nih.gov)
  • Metabolism of the isoflavones biochanin A, genistein, formononetin, daidzein, equol and prunetin, the lignans matairesinol, secoisolariciresinol, enterodiol and enterolactone and the coumestan coumestrol was investigated to study the metabolism of phytoestrogens in dairy cows, and the possibilities to influence the content in milk. (orgprints.org)
  • In any case, coumestrol has estrogenic activity that is 30 to 100 times greater than that of isoflavones. (wikipedia.org)
  • Soy contains many isoflavones, including the sub-classes ernistein, coumestrol and daidzein. (thenourishinggourmet.com)
  • Ellen B. Gold, PhD, professor and chair of the Department of Public Health at the University of California, Davis, and colleagues measured consumption of isoflavones, coumestrol, lignans, and fiber using a food frequency questionnaire at baseline and again in years 5 and 9. (medscape.com)
  • When passing to omasum, isoflavones and coumestrol mainly followed large particles, while lignans was in greater extent evenly distributed between phases. (orgprints.org)
  • Coumestrol is a coumestan which is part of the phytonutrient (a group of chemical compounds that occur naturally in plants and have multiple health benefits but are not considered essential to human health) family. (freefitnesstips.co.uk)
  • The Coumestan group includes coumestrol. (smart-publications.com)
  • Boué and colleagues 4 -for example, have shown that Aspergillus sojae induces the production of the coumestan phytoalexin, coumestrol, and the pterocarpan phytoalexins, glyceollins I-III in soybean cotyledons. (bmj.com)
  • The primary coumestan is coumestrol. (grainbininc.com)
  • Multivariate analysis, after adjustment for age, family history of prostate cancer, alcohol consumption, and total calorie intake, showed an inverse association between coumestrol (p = 0.03) and daidzein (p = 0.07) and prostate cancer risk. (nih.gov)
  • Coumestrol was first identified as a compound with estrogenic properties by E. M. Bickoff in ladino clover and alfalfa in 1957. (wikipedia.org)
  • The highest concentrations of coumestrol are found in clover, Kala Chana, a type of chick pea, and Alfalfa sprouts. (wikipedia.org)
  • Studies of coumestrol levels in alfalfa suggest that there may be a positive correlation between coumestrol production and infection of the plant by viruses, bacteria, and fungi. (wikipedia.org)
  • Coumestrol produced by alfalfa (Medicago sativa L.) can reduce the ovulation rate of ewes. (lincoln.ac.nz)
  • This study isolated agronomic factors that affect coumestrol levels in alfalfa. (lincoln.ac.nz)
  • However, in field-grown alfalfa there was a low relationship (R² = 0.388) between coumestrol content and visual fungal damage score which indicates a need for alternative methods of prediction. (lincoln.ac.nz)
  • When alfalfa was subjected to ~5 aphids per stem for 4 wk coumestrol increased from 2.4 ± 0.39 to 5.3 ± 0.65 mg kg⁻¹ DM. (lincoln.ac.nz)
  • This study highlights fungal pathogens traditionally not considered problematic in alfalfa stands due to limited effects on stand persistence and yield, as important causal agents of elevated coumestrol levels. (lincoln.ac.nz)
  • Coumestrol was present in the blood of goats (2·0 to 3·9 ng/ml) after feeding alfalfa hay at a rate supplying 12 mg coumestrol/24 hr/animal. (bioscientifica.com)
  • Coumestrol is the most potent of the phytoestrogens, but is some 100-200 times less potent than 17β-oestradiol, and almost 3000 times less potent than diethylstilboestrol. (bmj.com)
  • Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. (wikipedia.org)
  • Green peas contain a variety of phytochemicals like coumestrol which may have antioxidant activity (9) . (tarladalal.com)
  • Green peas are a rich source of phytochemicals, including coumestrol, saponins, phenolic acids (eg, ferulic and caffeic acid), and flavonoids like catechin and epicatechin. (todaysdietitian.com)
  • When 2 day old male Wistar rats are injected with coumestrol daily, they exhibit a decrease in size in the lumens of their seminiferous tubules and germ cells go through increased rates of apoptosis. (wikipedia.org)
  • Coumestrol produced accumulation of HeLa cells in G2/M phase, and subsequently induced apoptosis. (blogspot.com)
  • Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. (ewg.org)
  • Brussels sprouts and spinach also contain coumestrol at a lower level, according to researchers of the 2007 mini review published in 'Clinical Cases in Mineral and Bone Metabolism. (livestrong.com)
  • Coumestrol binds to the ERα and ERβ with similar affinity to that of estradiol (94% and 185% of the relative binding affinity of estradiol at the ERα and ERβ, respectively), although the estrogenic activity of coumestrol at both receptors is much less than that of estradiol. (wikipedia.org)
  • Similar effects were observed in estrogen treated cells, according to " Estrogenic activity of coumestrol , DDT, and TCDD in human cervical cancer cells " by Ndebele K, Graham B, Tchounwou PB. (blogspot.com)
  • Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity than 17α-estradiol, although the estrogenic potency of coumestrol at both receptors is much less than that of 17β-estradiol. (wikipedia.org)
  • When neonatal female mice were treated with coumestrol, similar reproductive irregularities occurred, and at 22 months old, atypical collagen distribution was observed in the uterine wall. (wikipedia.org)
  • We conclude that neonatal exposure to coumestrol does not alter reproductive organ structure or spermatogenic potential in male rats. (springer.com)
  • Neonatal rats and immature rats exposed to coumestrol had premature estrous cycles. (anabolicminds.com)
  • Coumestrol Confers Partial Resistance in Soybean Plants Against Cercospora Leaf Blight. (pubfacts.com)
  • Fluorescence and inmunohistological detection of estrogen receptors in dog testis and epidydimis after oral coumestrol administration. (nel.edu)
  • Serrano H, Perez-Rivero J, Martinez-Maya J, Aguilar-Setien A, Perez-Martinez M, Garcia-Suarez M. Fluorescence and inmunohistological detection of estrogen receptors in dog testis and epidydimis after oral coumestrol administration. (nel.edu)
  • Coumestrol induces apoptotic effects on placental choriocarcinoma cells. (greenmedinfo.com)
  • Coumestrol induces senescence in human breast cancer and colon cancer cells. (greenmedinfo.com)
  • Similarly, there were no significant differences among serum concentrations of testosterone, LHβ and FSH of coumestrol-treated rats and those of controls. (springer.com)
  • Methods: Different concentrations of coumestrol were tested for their protective efficacy against two toxic insults, lipopolysaccharide (LPS) and amyloid-beta peptide, on astrocytes. (elsevier.com)
  • However, the augmented FSHβ mRNA expression in coumestrol-treated rats did not negatively affect reproductive potential in male rats. (springer.com)
  • For some items, coumestrol, biochanin A and formononetin content are also included. (preparedfoods.com)
  • Based on extrapolation from studies done on animals, the maximum tolerable daily intake of coumestrol for human beings has been estimated at 22 μg per kg of body mass. (wikipedia.org)
  • In the estimation the risk of gastric cancer (GC) in relation to the individual and combined consumption of polyphenols and NOC precursors (nitrate and nitrite), found that for the first time, a protective effect for GC because of higher intake of cinnamic acids, secoisolariciresinol and coumestrol , and suggest that these polyphenols reduce GC risk through inhibition of endogenous nitrosation. (blogspot.com)
  • Peas also contain a high amount of a polyphenol known as coumestrol, which has been proven to decrease the risk of developing cancer especially colon cancer (10) (11) . (tarladalal.com)
  • Green Peas - contains a polyphenol called coumestrol, which can protect against stomach cancer. (amazonaws.com)
  • male rats that nursed from females with coumestrol in their diets were both less likely to mount a female rat and less likely to ejaculate, despite producing normal levels of testosterone. (wikipedia.org)
  • Female rats that were exposed to coumestrol neonatally did not adopt the lordosis position as much as those that were not exposed to coumestrol. (wikipedia.org)
  • Coumestrol has neuroprotective effects before and after global cerebral ischemia in female rats. (greenmedinfo.com)
  • Male rats were injected either with 100 μg coumestrol or DMSO (controls) daily during their first 5 d of life. (springer.com)
  • Whereas steady state levels of LHβ mRNA in coumestrol-treated rats did not differ from those of controls, steady state levels of FSHβ mRNA increased (37%) in treated animals. (springer.com)
  • Coumestrol binds as strongly as 17β-estradiol to both hERs. (go.jp)
  • In the clarification of the effects of coumestrol administration on Ca metabolism during pregnancy and in lactating mice, found that coumestrol did not affect serum Ca and the expression of vitamin D receptor protein in the duodenum and jejunum. (blogspot.com)
  • Coumestrol found in sunflower seeds when fed to the mother rat caused permanent reproductive problems in the rat pups: female pups when grown did not ovulate, and the male pups had altered mounting behavior and fewer ejaculations. (anabolicminds.com)
  • Los FIT seleccionados incluyeron flavonol (FOL), flavones (FES), flavanol (FAL), secoisolariciresinol (SE), matairesinol (MA), lariciresinol (LA), pinoresinol (PI), ácido cinámico (CA) y coumestrol (CU). El contenido de estos compuestos se obtuvo de cuatro diferentes fuentes de datos. (scielosp.org)
  • Lee, K.W. Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor. (mdpi.com)
  • High-performance liquid chromatographic assay of isoflavonoids and coumestrol from human urine. (nih.gov)
  • Analytes were isolated and concentrated by solid-phase extraction and separated by HPLC followed by identification through retention times and UV scans, and in the case of coumestrol additionally by fluorometric response. (nih.gov)
  • Coumestrol: helps the plant repair damaged cells. (google.com)
  • Coumestrol has been shown to accelerate the onset of puberty in mice. (wikipedia.org)
  • The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes. (elsevier.com)
  • Higher levels of coumestrol are also found in plants which had been damaged by aphids. (wikipedia.org)
  • According to the United States Department of Agriculture and Iowa State University database on isoflavanes and coumestrol, coumestrol is found in the following food items. (wikipedia.org)
  • Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. (greenmedinfo.com)
  • Haspin kinase was identified as a direct target protein of coumestrol using kinase profiling analysis. (mdpi.com)
  • Exposure to coumestrol immediately after birth resulted in an initial increase in uterine weight. (wikipedia.org)
  • Results: The results showed that coumestrol induced a modest but significant increase in viability of astrocytes, while the viability of astrocytes was reduced following exposure to LPS and amyloid-beta peptide. (elsevier.com)
  • Coumestrol had no effect on weights of testes and sex accessory organs, or sperm count. (springer.com)
  • These findings suggest that the anti-cancer effect of coumestrol is due to the direct targeting of haspin kinase. (mdpi.com)
  • Pea aphids had a minor effect on coumestrol content. (lincoln.ac.nz)
  • The addition of coumestrol could reverse the toxic effect induced by LPS and amyloid-beta peptide. (elsevier.com)
  • The estrogen receptor expression was upregulated by coumestrol, while the effect was more obvious on estrogen receptor-beta (ER-beta). (elsevier.com)
  • Coumestrol Counteracts Interleukin-1ß-Induced Catabolic Effects by Suppressing Inflammation in Primary Rat Chondrocytes. (harvard.edu)
  • In the present study, we investigated coumestrol, a natural compound exhibiting broad anti-cancer effects against skin melanoma, lung cancer and colon cancer cell growth. (mdpi.com)
  • Both the LPS and amyloid-beta peptide enhanced interleukin 1, interleukin 6, and tumor necrosis factor-alpha synthesis and these effects were inhibited by 10 -9 M coumestrol. (elsevier.com)
  • Levels of coumestrol within individual plants of the same species are variable. (wikipedia.org)
  • Further study is required to fully explain the cause of the correlation between damage, infection, and coumestrol levels. (wikipedia.org)
  • In this study, we demonstrated that high levels of coumestrol (COU) were associated with purple symptoms of CLB and that COU has strong antioxidant activity. (pubfacts.com)
  • When bulls graze on pastures containing coumestrol, metaplasia occurs in the prostate and bulbourethral glands, and sperm maturation is suppressed. (wikipedia.org)
  • The chemical shape of coumestrol orients its two hydroxy groups in the same position as the two hydroxy groups in estradiol, allowing it to inhibit the activity of aromatase and 3α-hydroxysteroid dehydrogenase. (wikipedia.org)
  • Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis. (greenmedinfo.com)
  • A high coumestrol diet has also been shown to induce early development of the vulva and udder of female lambs. (wikipedia.org)