Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.
A plant genus of the family CLUSIACEAE. Members contain xanthones and BENZOPHENONES. The common name of Mamey is also used with POUTERIA.
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.
A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A plant genus of the family APIACEAE. Members contain COUMARINS.
Linear furanocoumarins which are found in many PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA from which they were originally discovered. They can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate PYRIMIDINES, resulting in PHOTOSENSITIVITY DISORDERS.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.
A coronary vasodilator agent.
The outer layer of the woody parts of plants.
COUMARINS with an amino group, exemplified by NOVOBIOCIN.
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
A plant genus of the family CLUSIACEAE. Members contain costatolide, calanolides and 4-phenylfuranocoumarins (FUROCOUMARINS).
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
A plant genus of the family Apiaceae.
A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Agents that prevent clotting.
Coumarin derivative that acts as a long acting oral anticoagulant.
Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.
A plant genus of the family ASTERACEAE. Members contain scandenolide (a sesquiterpene lactone) and germacranolides.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.
A plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida.
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
Substances causing insects to turn away from them or reject them as food.
A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin.
A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.
A plant genus of the family VERBENACEAE. Members contain lantadene and other TRITERPENES.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
Substances and materials manufactured for use in various technologies and industries and for domestic use.
Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.
Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. (1/1334)

The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. The more recently developed reversible MAO inhibitors with selectivity for either the MAO-A or MAO-B isoenzyme forms have not been studied extensively in animal models of epilepsy, so it is not known which type of MAO inhibitor is particularly effective in this respect. We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine. Esuprone proved to be an effective anticonvulsant in the kindling model with a similar potency as L-deprenyl. In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A. Drugs inhibiting both MAO-A and MAO-B to a similar extent (tranylcypromine) or combinations of selective MAO-A and MAO-B inhibitors (esuprone plus LU 53439) had no advantage over MAO-A inhibition alone, but were less well tolerated. The data thus suggest that selective MAO-A inhibitors such as esuprone may be an interesting new approach for the treatment of epilepsy.  (+info)

7-ethoxycoumarin deethylation activity in perfused isolated rat brain. (2/1334)

7-ethoxycoumarin (7-EC) deethylation activity was measured in the perfused rat brain in situ. Infusion of 7-EC into a brain through an internal carotid artery resulted in the formation of 7-hydroxycoumarin (7-HC) and its conjugates in the effluent perfusate collected from the superior vena cava. The rate of formation of products was 200 nmol/h/g when 130 microM 7-EC was infused. This value was much higher (more than 100 times) than that determined from the brain microsomal activity ( approximately 1 nmol/h/g), indicating that the activity determined with microsomes was an underestimate. This value was comparable to the activity in the perfused liver (30-50%), suggesting that drug metabolizing enzymes can play important roles within the brain. Pretreatment of rats with P-450 inducers such as phenobarbital and beta-naphthoflavone increased the deethylation activity in the perfused brain, as in the perfused liver. We conclude that the perfused brain is suitable for evaluating drug metabolizing activities under physiological conditions.  (+info)

Effect of praeruptorin C on spontaneous [Ca2+]i transients in cultured myocardial cells of neonatal rats. (3/1334)

AIMS: To study the effects of praeruptorin C (Pra-C) on [Ca2+]i transients in cultured neonatal myocardiocytes. METHOD: Using Ca(2+)-sensitive fluorescent indicator, Fura 2-AM, spontaneous cytosolic Ca2+ transients were measured in cultured myocardial cells of neonatal rats. RESULTS: Pra-C 10, 30 mumol.L-1 caused a decrease in the peak of Ca2+ transients. Pra-C 30 mumol.L-1 and 10-30 mumol.L-1 inhibited partly the stimulatory effects of CaCl2 4.8 mmol.L-1 and Bay k 8644 100 nmol.L-1 on peak Ca2+ transients, respectively. Pra-C did not cause any marked change in the basal [Ca2+]i level between beats. Pra-C inhibited the reduced [Ca2+]i transients after inhibition of sarcoplasmic reticulum Ca2+ release in ryanodine pretreated cells. CONCLUSIONS: Pra-C inferred with the Ca2+ influx responsible for excitation-contraction coupling in myocardiocytes.  (+info)

Effects of praeruptorine C on the intracellular free calcium in normal and hypertrophied rat ventricular myocytes. (4/1334)

AIM: To study the intracellular free calcium ([Ca2+]i) in normal and hypertrophic left ventricular myocytes isolated from adult rat hearts and the effects of praeruptorine C (Pra-C) on them. METHODS: [Ca2+]i of single myocyte was measured with Fura 2-AM. RESULTS: The resting [Ca2+]i was 87 +/- 4 nmol.L-1 in normal left ventricular myocytes, 123 +/- 7 nmol.L-1 in hypertrophied myocytes. After exposure to KCl (20, 40, and 60 mmol.L-1), the [Ca2+]i were increased by 66%, 141%, and 268% in normal myocytes, and 77%, 185%, and 243% in hypertrophic myocytes, respectively. Pra-C (1, 10, and 100 mumol.L-1) concentration-dependently inhibited the [Ca2+]i elevation caused by KCl (35 mmol.L-1) or norepinephrine (20 mumol.L-1) in both normal and hypertrophied myocytes. All of the effects of Pra-C were similar to that of nifedipine. CONCLUSION: [Ca2+]i of hypertrophied myocytes was higher than that of normal ones and Pra-C decrease the [Ca2+]i elevation in left ventricular myocytes resulted from its calcium channel blockade.  (+info)

Rapid identification of Staphylococcus aureus by using fluorescent staphylocoagulase assays. (5/1334)

Two rapid (1-h) assays for the detection of Staphylococcus aureus staphylocoagulase were developed by using the fluorogenic thrombin substrates N-t-boc-Val-Pro-Arg-7-amido-4-methylcoumarin (VPA) and N-t-boc-beta-benzyl-Asp-Pro-Arg-7-amido-4-methylocoumarin (BB). The assays were compared to the tube coagulase test and latex agglutination (LA) (Sanofi Diagnostics Pasteur, Guildford, Surrey, United Kingdom) by using 406 clinical isolates of staphylococci, and they produced positive and negative predictive values of 99.2 and 99. 1% for LA, 98.9 and 92.7% for VPA, and 98.9 and 99.1% for BB. Fluorescent assays used colonies from solid media, thereby eliminating the need for broth cultures, and were performed in microtiter trays, thus making them suitable for large-scale screening.  (+info)

Caspase-dependent activation of calpain during drug-induced apoptosis. (6/1334)

We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced apoptosis of HL-60 cells (Wood, D. E., Thomas, A., Devi, L. A., Berman, Y., Beavis, R. C., Reed, J. C., and Newcomb, E. W. (1998) Oncogene 17, 1069-1078). Here we show the sequential activation of caspases and calpain during drug-induced apoptosis of HL-60 cells. Time course experiments using the topoisomerase I inhibitor 9-amino-20(S)-camptothecin revealed that cleavage of caspase-3 substrates poly(ADP-ribose) polymerase (PARP) and the retinoblastoma protein as well as DNA fragmentation occurred several hours before calpain activation and Bax cleavage. Pretreatment with the calpain inhibitor calpeptin blocked calpain activation and Bax cleavage but did not inhibit PARP cleavage, DNA fragmentation, or 9-amino-20(S)-camptothecin-induced morphological changes and cell death. Pretreatment with the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk) inhibited PARP cleavage, DNA fragmentation, calpain activation, and Bax cleavage and increased cell survival by 40%. Interestingly, Z-VAD-fmk-treated cells died in a caspase- and calpain-independent manner that appeared morphologically distinct from apoptosis. Our results suggest that excessive or uncontrolled calpain activity may play a role downstream of and distinct from caspases in the degradation phase of apoptosis.  (+info)

Activation of Xenopus eggs by proteases: possible involvement of a sperm protease in fertilization. (7/1334)

Egg activation in cross-fertilization between Xenopus eggs and Cynops sperm may be caused by a protease activity against Boc-Gly-Arg-Arg-MCA in the sperm acrosome. To determine the role of the sperm protease in fertilization, the protease was purified from Cynops sperm using several chromatographic techniques. We found that purified sperm protease readily hydrolyzes Boc-Gly-Arg-Arg-MCA and Z-Arg-Arg-MCA, that protease activity was inhibited by the trypsin inhibitors aprotinin and leupeptin, and that not only the purified protease, but also cathepsin B, induces activation in Xenopus eggs. We inseminated unfertilized Xenopus eggs with homologous sperm in the presence of various peptidyl MCA substrates or protease inhibitors and demonstrated that trypsin inhibitors or MCA substrates containing Arg-Arg-MCA reversibly inhibited fertilization of both fully jellied and denuded eggs. Sperm motility was not affected by the reagents. An extract obtained from Xenopus sperm showed hydrolytic activity against Boc-Gly-Arg-Arg-MCA, Z-Arg-Arg-MCA, and Arg-MCA. These results suggest that the tryptic protease in Xenopus sperm is involved in fertilization, most likely by participating in egg activation.  (+info)

Core RNA polymerase from E. coli induces a major change in the domain arrangement of the sigma 70 subunit. (8/1334)

Luminescence resonance energy transfer measurements were used to show that binding of E. coli core RNA polymerase induced major changes in interdomain distances in the sigma 70 subunit. The simplest model describing core-induced changes in sigma 70 involves a movement of the conserved region 1 by approximately 20 A and the conserved region 4.2 by approximately 15 A with respect to conserved region 2. The core-induced movement of region 1 (autoinhibition domain) and region 4.2 (DNA-binding domain) provides structural rationale for allosteric regulation of sigma 70 DNA binding properties by the core and suggests that this regulation may not only involve directly the autoinhibition domain of sigma 70 but also could involve a modulation of spacing between DNA-binding domains of sigma 70 induced by binding of core RNAP.  (+info)

Unscramble cumarin, Unscramble letters cumarin, Point value for cumarin, Word Decoder for cumarin, Word generator using the letters cumarin, Word Solver cumarin, Possible Scrabble words with cumarin, Anagram of cumarin
K2CO3 was utilized as an friendly catalyst for the environmentally fast and simple synthesis of ten 3-substituted coumarin derivatives by the Knoevenagel condensation of salicylaldehyde and its derivatives with diethyl malonate, ethyl acetoaceate or methyl acetoaceate under solvent free conditions. Three effect on the yield of coumarin-3-ethyl formate was investigated. The results showed that coumarin-3-ethyl formate were obtained 88.1% yields within based on 20 mmol of salicylaldehyde, molar ratio of salicylaldehyde to diethyl malonate 1:1.2, dosage of K2CO3 0.1 mmol and time of reaction 15-18 min. When ethyl (or methyl) acetoaceate displaces diethyl malonate, 3-acetyl coumarin were synthesized with the yield 84.7%(or 82.9%). When solid substituted salicylaldehyde displaces salicylaldehyde with diethyl malonate, ethyl (or methyl) acetoacetate at a mole ratio of 1:2.0, eight 3-substituted coumarin derivatives were synthesized with the yield from 62.5%-89.0%(or ...
Two novel coumarin-based ligands, coumarin-6,7-dioxyacetic acid (1) (cdoaH(2))and 4-methylcoumarin-6,7-dioxyacetic acid (2) (4-MecdoaH(2)), were reacted with copper(II) and manganese(II) salts to give [Cu(cdoa)(H2O2)]center dot 1.5H(2)O (3), [Cu(4-Mecdoa)(H2O2)(2)] (4), [Mn(cdoa)(H2O2)(2)] (5) and [Mn(4-Mecdoa)(H2O2)2] center dot 0.5H(2)O (6). The metal complexes, 3-6, were characterised by elemental analysis, IR and UV-Vis spectroscopy, and magnetic susceptibility measurements and were assigned a polymeric structure. 1 and 2 react with Cu(II) in the presence of excess 1,10-phenanthroline (phen) giving [Cu(cdoa)(phen)(2)]center dot 8.8H(2)O (7) and [Cu(4-Mecdoa)(phen)(2)]center dot 13H(2)O (8), respectively. The X-ray crystal structures of 7 and 8 confirmed trigonal bipyramidal geometries, with the metals bonded to the four nitrogen atoms of the two chelating phen molecules and to a single carboxylate oxygen of the dicarboxylate ligand. The complexes were screened for their antimicrobial ...
Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnkes reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.
0039] 3-Diethylamino-6-methylfluorane, 3-diethylamino-6-methyl-7-anilinofluorane, 3-diethylamino-6-methyl-7-(o,p-dimethylanilino)fluorane, 3-diethylamino-6-methyl-7-chlorofluoran, 3-diethylamino-6-methyl-7-(m-trifluoromethylanilino) fluorane, 3-diethylamino-6-methyl-7-(o-chloroanilino) fluorane, 3-diethylamino-6-methyl-7-(p-chloroanilino) fluorane, 3-diethylamino-6-methyl-7-(o-fluoroanilino) fluorane, 3-diethylamino-6-methyl-7-(m-methylanilino) fluorane, 3-diethylamino-6-methyl-7-n-octylanilino fluorane, 3-diethylamino-6-methyl-7-n-octylamino fluorane, 3-diethylamino-6-methyl-7-benzylamino fluorane, 3-diethylamino-6-methyl-7-dibenzylamino fluorane; 3-diethylamino-6-chloro-7-methyl fluorane, 3-diethylamino-6-chloro-7-anilino fluorane, 3-diethylamino-6-chloro-7-p-methylanilino fluorane, 3-diethylamino-6-ethoxyethyl-7-anilino fluorane, 3-diethylamino-7-methyl fluorane, 3-diethylamino-7-chloro fluorane, 3-diethylamino-7-(m-trifluoromethylanilino) fluorane, 3-diethylamino-7-(o-chloroanilino) ...
Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against |i|Anopheles arabiensis|/i|, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered
Coumarin is often found in tobacco products and artificial vanilla substitutes, though it has been banned as a food additive in numerous countries since the mid-20th century because it is moderately toxic to the liver and kidneys, with an LD50 of 275 mg/kg - low compared to related compounds. Although only somewhat dangerous to humans, coumarin is a potent rodenticide: rats and other rodents largely metabolize it to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans largely metabolize it to 7-hydroxycoumarin, a compound of lower toxicity. Coumarin was banned as a food additive in the United States in 1978. OSHA considers this compound to be only a lung-specific carcinogen, and not classifiable as to its carcinogenicity to humans [2]. Coumarin was banned as an adulterant in cigarettes by tobacco companies in 1997, but due to the lack of reporting requirements to the US Department of Health and Human Services it was still being used as a flavoring ...
adenosine triphosphate (7-(diethylamino)coumarin-4-yl)methyl ester: a caged form of ATP for light controlled transcription reactions in vitro; structure in first source
Coumarins are a structurally diverse group of natural substances derives from plants that display a host of bioactivities. In this paper, we will introduce the reader to coumarins and their applications as medicinal substances. The great diversity in courmarin structure will be discussed along with their extensive use as pharmaceutical agents. Coumarins display a wide range of antimicrobial activity and applications of coumarins as antifungal and antiviral agents will be addressed. Other properties of coumarins such as their role in neuroprotection, anticancer, and as antioxidants will also be reviewed ...
Small molecules containing a coumarin moiety display antibacterial efficacy against MRSA (32-34). In this study, coumarin derivate DCH exhibited the selective in vitro and in vivo antibacterial activity against MRSA; however, DCH had no obvious activity against Gram-negative bacteria including E. coli, K. pneumoniae, A. baumannii, and Salmonella typhimurium, and WT P. aeruginosa and efflux pump mutant or deleted stains including ΔmexB, ΔmexN, ΔmexW, and ΔmuxA P. aeruginosa. These results indicated that the selective activity of DCH against Staphylococcus was perhaps due to the difference in the possible target or cellular structure between Gram-positive and Gram-negative bacteria.. In this study, some new 4-hydroxycoumarin derivatives were demonstrated to be capable of remarkably inhibiting the growth and biofilm formation of MRSA USA300 strain, and dihydropyran derivatives almost had no antibacterial activities. The differences in bioactivity among these 4-hydroxycoumarin compounds might be ...
Methyl coumarin-3-carboxylate | C11H8O4 | CID 30553 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Coumarin-4-acetic acid 7-beta-D-galactopyranoside/AFI127615741 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
6,7-Bis(carboxymethoxy)coumarin-4-yl)methyl-adenosine-3,5-cyclic monophosphate(bcmcm-caged camp)/ACM339291519 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Effect of synthetic coumarin derivatives on HT1080 fibrosarcoma cell invasion. Chemoinvasion and chemotaxis were evaluated in Transwell cell culture inserts coa
Following absorption, coumarin binds to albumin and other plasma proteins. After administration of the optimal dose, a large proportion of the interstitial plasma proteins reach the maximum carrying amount of coumarin attached to these proteins. This complex-albumin coumarin is phagocytosed by macrophages and monocytes, resulting in amino acids and peptides which are simultaneously released into the extracellular proteases. The protein fragments of the addition product of these processes are removed from the gap through the veins, in contrast to the proteins of high molecular weight which depend on the lymphatic system to be removed. Therefore, these protein fragments of lower molecular weight, high diffusion coefficient and its consequent ability to penetrate small pores play a role in the mechanism of action of Venalot Depot ®. After the removal of proteins accumulated fluid drainage is performed accordingly and tissue restoration. The immediate effect of coumarin rheological and troxerutin ...
ent policies and plans are also discussed as well as manufacturing processes and cost structures. Coumarin market report also states import/export, supply and figures as well as cost, price, revenue and gross margin by regions (United States, EU, China and Japan), and other regions can be added.. For Pre-Order Enquiry on Coumarin market, [email protected] http://www.360marketupdates.com/enquiry/pre-order-enquiry/10480486 Then, Coumarin market report focuses on major leading industry players with information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials, and downstream consumers analysis is also carried out. Whats more, the Coumarin industry development trends and marketing channels are analysed.. For each player, product details, capacity, price, cost, gross and revenue numbers are given. Their contact information is provided for better understanding.. Finally, the feasibility of new investment ...
Coumarin China Supplier of Coumarin (CAS: 91-64-5) picture from Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. view photo of Coumarin, Food Additives, Chemical.Contact China Suppliers for More Products and Price.
Looking for Coumarin? Find out information about Coumarin. C9H6O2 The anhydride of o -coumaric acid; a toxic, white, crystalline lactone found in many plants and made synthetically; used in making perfume and soap.... Explanation of Coumarin
The only frequent adverse reaction during therapy with oral anticoagulants is bleeding due to depression of vitamin K-dependent hepatic clotting proteins. Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign events such as gastrointestinal dysfunction, hypersensitivity dermatitides, drug fever, and alopecia. Only one serious complication remains poorly understood: coumarin necrosis of skin and subcutaneous tissue. Widely reported in Europe (1-10) it has received little attention in English-speaking countries (11-14) and is still being misinterpreted as a hemorrhagic effect.. Although clinical use of bishydroxycoumarin began in 1940, coumarin necrosis was not recognized until ...
Kabeya, L. M., Marchi, A. A. de, Kanashiro, A., Lopes, N. P., Silva, C. H. T. de P. da, Pupo, M. T., & Lucisano-Valim, Y. M. (2007). Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: synthesis and structure-activity relationships. Bioorganic & Medicinal Chemistry, 15( 3), 1516-1524. doi:10.1016/j.bmc.2006.10. ...
4-Hydroxy coumarin (1.0 mole) and potassium carbonate (1.5 mole) in DMF (3 vol) as a solvent media was heated up to 75 °C and solution of 3-methyl-1-phenyl-1 H-pyrazol-5(4H)-one (1.0 mole) in DMF (2 vol) at 75 °C was added. The reaction mass stirred for 5 h at 75 °C (TLC monitoring: hexane/ethyl acetate 5:5, Rf = 0.47). After the completion of reaction, the product was obtained by adjusting the pH at 4-5 by HCl. It was filtered, dried and recrystallized from ethyl acetate and hexane to give the 4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (6).. Light cream crystal. Yield 73 %, m.p. 153-157 °C, IR (KBr, cm-1) (Fig. S15): 1631 cm-1 (C=O), 3084-3176 cm-1 (OH), 1375-1390 cm-1 (CH2), 759 cm-1, 775 cm-1 (substituted benzene); 1H NMR (400 MHz, DMSO) (Fig. S7)11.83 (s, 1H, OH), 7.11-8.03 (m, 9H, Ar-H), 2.76 (m, 1H, CH), 2.18-2.19 (s, 3H, CH3); C19H14N2O4 (334.32); Found (C-68.16, H-4.29, N-8.37 %) requires (C-68.26, H-4.22, O-19.14, N-8.40 %) MS: m/z: 335.4 ...
TY - JOUR. T1 - Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus. AU - Tsay, Shwu Chen. AU - Hwu, Jih Ru. AU - Singha, Raghunath. AU - Huang, Wen Chieh. AU - Chang, Yung Hsiung. AU - Hsu, Ming Hua. AU - Shieh, Fa Kuen. AU - Lin, Chun Cheng. AU - Hwang, Kuo Chu. AU - Horng, Jia Cherng. AU - De Clercq, Erik. AU - Vliegen, Inge. AU - Neyts, Johan. PY - 2013/3/18. Y1 - 2013/3/18. N2 - A new compound library that contained 20 hinged benzimidazole-coumarin hybrids and their β-d-ribofuranosides was established. The anti-hepatitis C virus (HCV) activity of all novel coumarin derivatives, which were obtained by use of organic synthetic methods, was tested. Two of these hybrids exhibited appealing EC50 values of as low as 3.0 and 5.5 μM. The best selectivity index was 14. The incorporation of a d-ribofuranose into the hinged hybrids provided the corresponding nucleosides with the β configuration, one of which inhibited HCV replication with an EC50 value ...
The eleven recombinant human cytochromes P450 (1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 3A5, and 4A11 SUPERSOMES), 3-cyano-7-ethyoxycoumarin (CEC), 7-methoxy-4-trifluoromethylcoumarin (MFC), 7-benzyloxy-trifluoromethylcoumarin (BFC), and 3-[2-(N,N diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin (AMMC) were purchased from BD Biosciences (Woburn, MA). The 7-ethoxy-4-trifluoromethylcoumarin (EFC) was purchased from Molecular Probes (Eugene, OR). Glutathione, PCP, 1-(1-(phenyl-d5)-cyclohexyl)piperidine (d5-PCP), NADPH, and ferrous chloride were all purchased from Sigma (St. Louis, MO). Thirty-percent hydrogen peroxide was a JT Baker solvent (Phillipsburg, NJ). Authentic standards for PCP metabolites M1-M3 and M5 (Fig. 1) were obtained from within the Pfizer chemical archives (Pfizer Inc., Groton, CT). The PCP ketone derivatives, 4-phenyl-4-piperidinecyclohexanone and 1-(1-phenylcyclohexyl)piperidin-4-one, were also obtained from the Pfizer chemical archives.. Fenton Reactions. A typical ...
Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.
2: 42%, VKORC1*3: 38%, and VKORC1*4: 20%), which were in complete linkage disequilibrium. These haplotypes were further subdivided by additional polymorphisms. Haplotype VKORC1*2 includes a SNP in the promoter region (c.-1639G>A, dbSNP:rs17878363 that was identified as a marker for low dose warfarin requirement.. In a cohort of 50 consecutive patients without mutations in the VKORC1 coding region who presented with phenotypes of either increased coumarin sensitivity or partial coumarin resistance we found a strong association of VKORC1 haplotypes and the observed phenotype. 93% of patients with increased coumarin sensitivity but none of patients with partial coumarin resistance were found to be homozygous for VKORC1*2. Vice versa, non VKORC1*2 haplotypes were found homozygous in 86% of patients with partial coumarin resistance but in none of patients with increased coumarin sensitivity.. The VKORC1*2 haplotype also explains inter-ethnic differences in coumarin requirement. Haplotype analysis ...
Abstract: The development of antioxidants as useful drugs for the treatment of neurodegenerative diseases such as Alzheimers is extremely challenging in medicinal chemistry. Coumarins have attracted great attention as possible therapeutic tools against oxygen radicals in human degenerative diseases. In order to establish the possible structure-antioxidant activity relationship, a series of twenty four 4-methylcoumarin derivatives were examined by employing reducing power measurements, and comparison with bond dissociation enthalpy and ionization potential calculations. Based on the reducing potency of 4-methylcoumarin derivatives with respect to trolox, these compounds were classified into five groups as most active, more active, moderately active, less active and inactive derivatives. The presence of hydroxyl groups is an essential requirement for the activity, and substitution of hydroxyl groups by methoxy groups leads to non-active derivatives. The results revealed that dihydroxyl ...
We report a new method, Interaction-Dependent PRobe Incorporation Mediated by Enzymes, or ID-PRIME, for imaging protein-protein interactions (PPIs) inside living cells. ID-PRIME utilizes a mutant of Escherichia coli lipoic acid ligase, LplA[superscript W37V], which can catalyze the covalent ligation of a coumarin fluorophore onto a peptide recognition sequence called LAP1. The affinity between the ligase and LAP1 is tuned such that, when each is fused to a protein partner of interest, LplA[superscript W37V] labels LAP1 with coumarin only when the protein partners to which they are fused bring them together. Coumarin labeling in the absence of such interaction is low or undetectable. Characterization of ID-PRIME in living mammalian cells shows that multiple protein-protein interactions can be imaged (FRB-FKBP, Fos-Jun, and neuroligin-PSD-95), with as little as 10 min of coumarin treatment. The signal intensity and detection sensitivity are similar to those of the widely used fluorescent protein ...
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Development of efficient unimolecular visible light photoinitiators (PIs) with photobleaching capabilities, which is essential for various biomedical applications and photopolymerization of thick materials, remains an emerging challenge. Based on the photochemistry of heteroaromatic compounds, unimolecular visible
coumarin 7-hydroxylase: CYP2A5 hyrdoxylates DHEA in at least three positions (7alpha, 7beta, and 2alpha); some enzyme preparations hydroxylate at position 3 & position 7; if cytochrome P-450coh is mutated at position 209, its substrate specificity is changed from coumarin hydroxylation (coh) to steroid hydroxylation
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7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. Buy 7ACC1 (DEAC; Coumarin D 1421; D 1421) from AbMole BioScience.
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray New Talent: Europe
A Novel One Pot Facile Synthesis of 1,2,4-Triazolo-1,3,4-Thiadiazepino Fused Coumarins and Their Antimicrobial and Antituberculosis Activity Studies, Dharati S Patel, Nilesh J Pate
The first region 4 open reading frame 3 protein FLNA (E4-ORF3; UniProt Identification type:entrez-protein attrs :text:P04489″ term_id :119084″ term_text :P04489″P04489) may be the most extremely conserved of most adenovirus-encoded gene items on the amino acidity level. supplementary/tertiary framework and the capability to type heterogeneous higher-order multimers in option. Importantly a non-functional E4-ORF3 mutant proteins L103A forms a well balanced dimer with WT supplementary structure content. As the L103A mutant is certainly Coumarin 30 not capable of PML reorganization this result shows that higher-order multimerization of E4-ORF3 could be necessary for the experience of the proteins. To get this hypothesis we demonstrate the fact that E4-ORF3 L103A mutant proteins works as a dominant-negative effector when coexpressed using the WT E4-ORF3 in mammalian cells. It prevents WT E4-ORF3-mediated PML monitor development presumably by binding towards the WT proteins and ...
Coumarin attenuates hepatic steatosis by down-regulating lipogenic gene expression in mice fed a high-fat diet - Volume 109 Issue 9 - Min Young Um, Mi Kyeong Moon, Jiyun Ahn, Tae Youl Ha
Coumarin 343;55804-65-4;1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylicacid, 2,3,6,7-tetrahydro-11-oxo-;ABP001118.Active Biopharma Corp
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
Sigma-Aldrich offers Sigma-C0855, Z-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrobromide for your research needs. Find product specific information including CAS, MSDS, protocols and references.
TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE 63909-29-5 NMR spectrum, TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE H-NMR spectral analysis, TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE C-NMR spectral analysis ect.
BioAssay record AID 513048 submitted by ChEMBL: Inhibition of human caspase-3-mediated apoptosis assessed as Ac-DEVD-7-amino-4-methylcoumarin cleavage product at 100 uM by fluorescence assay.
7-Amino-4-methylcoumarin (AMC) can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates. The fluorescence spectra of AMC is not subject to variability due to pH-dependent protonation/deprotonation when assayed near or above physiologica
Gentaur molecular products has all kinds of products like :search , Biovis \ 7-Amino-4-methylcoumarin; Appearance Yellow to yellow green solid \ 1844-25 for more molecular products just contact us
Lehnert, S, Toxicity to tumor cells of combined treatments with diethylamino- reserpine and radiation. Abstr. (1982). Subject Strain Bibliography 1982. 3894 ...
Looking for Marevan? Find out information about Marevan. anticoagulant anticoagulant , any of several substances that inhibit blood clot formation . Some anticoagulants, such as the coumarin derivatives... Explanation of Marevan
Gilvocarcin V (GV) and ravidomycin (RMV) exhibit excellent antitumor activities in the presence of near-UV light at low concentration maintaining a low in vivo cytotoxicity. Although, the exact molecular mechanism for in vivo actions of these antibiotics has yet to be determined, a [2+2] cycloaddition reaction of the vinyl side chain with DNA thymidine residues in addition to the inhibition of topoisomerase II and DNAhistone H3 cross-linking are reported for the GVs mechanism of action. Such activities have made these molecules interesting candidates for the biosynthetic investigation to generate analogues with improved activity/solubility. Previous biosynthetic studies have suggested that the GV biosynthetic pathway involves a number of synchronously occurring transformations leading to the oxidative C-C bond cleavage and other intriguing biosynthetic reactions, such as the vinyl side chain formation, methylations, Cglycosylation and dehydrogenation. Although gene inactivation results identified many
A new coumarin identified as 5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one (isoobtusitin) was isolated… Expand ...
Keywords: Farmacie/Biofarmaceutische wetenschappen (FARM), Epidemiology, Farmacie(FARM), Biomedische technologie en medicijnen, Ziekenhuisstructuur en organisatie van de gezondheidszorg, Public ...
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
Looking for online definition of Coumarins in the Medical Dictionary? Coumarins explanation free. What is Coumarins? Meaning of Coumarins medical term. What does Coumarins mean?
Interactions of several 7-aminocoumarins with human serum albumin (HSA) were studied by using fluorescence spectroscopic technique and modeling studies. There is a large change in fluorescence spectral parameters like intensity, emission maxima and anisotropy for all aminocoumarins. There were two binding sites for cou-1, 311 and a single binding site for other coumarins. The binding constant(s) are large for all coumarins reflective of a strong binding. These spectral studies show that structural variants at the third, fourth and seventh position affects binding. The probable location of these coumarins in domain Ii has been predicted based on modeling. The effect of structural modification on the efficiency of binding was obtained for various other coumarins, using modeling.. ...
Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K-dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy ...
Background and objectives: Interaction of compounds with ct-DNA can affect the replication, protein synthesis and cell division. Different species of the genus Ferula (Apiaceae) have shown various biomedical applications for many centuries. Biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins. Consequently, binding studies of sesquiterpen coumarin with ct-DNA are useful for the understanding of the reaction mechanism and providing guidance for the application and design of new and more efficient drugs targeted to DNA. Interaction of galbanic acid (GA) with ct-DNA, was evaluated by cyclic voltammetry (CV), diggerential pulse voltammetry (DPV), enhancement fluorescence, UV-VIS and FT-IR spectroscopy. Methods: The oleo gum-resin of Ferula assa-foetida was collected and dried in spring. Hexane extract of gum was prepared and defatted. Several coumarins were purified
L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 115918-60-0 safety info, L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE chemical safety search, Chemical L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE safety technical specifications ect.
Coumarin is acclimated in assertive perfumes and bolt conditioners. Coumarin has been acclimated as an balm enhancer in aqueduct tobaccos and assertive alcoholic drinks, although in accepted it is banned as a flavorant aliment additive, due to apropos apropos its hepatotoxicity in beastly models. The chat Tonka for tonka beans is taken from the Galibi…
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity ...
Patients receiving concomitant capecitabine and oral coumarin‐derivative anticoagulant therapy should have their anticoagulant response (INR or prothrombin time) monitored frequently in order to adjust the anticoagulant dose accordingly. A clinically important capecitabine‐warfarin drug interaction was demonstrated in a clinical pharmacology trial. Altered coagulation parameters and/or bleeding, including death, have been reported in patients taking capecitabine concomitantly with coumarin‐derivative anticoagulants such as warfarin and phenprocoumon. Post‐marketing reports have shown clinically significant increasesin prothrombin time and INR in patients who were stabilised on anticoagulants at the time capecitabine was introduced. These events occurred within several days and up to several months after initiating capecitabine therapy and, in a few cases, within 1 month after stopping capecitabine. These events occurred in patients with and without liver metastases. Age greater than 60 ...
0049] Nucleotides for nucleic acid sequencing according to the invention preferably include a detectable label that is directly or indirectly detectable. Preferred labels include optically-detectable labels, such as fluorescent labels. Examples of fluorescent labels include, but are not limited to, Atto dyes, 4-acetamido-4-isothiocyanatostilbene-2,2disulfonic acid; acridine and derivatives: acridine, acridine isothiocyanate; 5-(2-aminoethyl)aminonaphthalene-1-sulfonic acid (EDANS); 4-amino-N-[3-vinylsulfonyl)phenyl]naphthalimide-3,5 disulfonate; N-(4-anilino-1-naphthyl)maleimide; anthranilamide; BODIPY; Brilliant Yellow; coumarin and derivatives; coumarin, 7-amino-4-methylcoumarin (AMC, Coumarin 120), 7-amino-4-trifluoromethylcouluarin (Coumaran 151); cyanine dyes; cyanosine; 4,6-diaminidino-2-phenylindole (DAPI); 55-dibromopyrogallol-sulfonaphthalein (Bromopyrogallol Red); 7-diethylamino-3-(4-isothiocyanatophenyl)-4-methylcoumarin; diethylenetriamine pentaacetate; ...
TY - JOUR. T1 - A model of lymphoedema in the rabbits ear - The effects of the benzopyrones. AU - Casley-Smith, J. R.. AU - Clodius, L.. AU - Piller, N. B.. AU - Földi, M.. PY - 1977/3. Y1 - 1977/3. N2 - The dorsal surface of the rabbits ear is an easy place in which to produce a long-lasting lymphoedema, since the draining collecting lymphatics can readily be occluded. After six weeks of experimental lymphostasis the fine structure was examined and found to be identical with that observed elsewhere: The lymph capillary junctions were open here, as in some other regions where their support is not great. The benzopyrones produced their usual considerable reduction in the amounts of excess protein and oedema in the tissues. While they also reduced the concentration of protein in the lymphatics, they could not reduce their excessive dilatation, nor the increased numbers of open junctions, because the system was still occluded. After 32 weeks of experimental lymphostasis without benzopyrone ...
Hassanzadeh Khayyat, Mohammad and Vahdati-Mashhadian, Nasser and Eghbal, Saeed and Jalali, Navid (2013) Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population. Iranian Journal of Basic Medical Sciences, 16 (4). pp. 610-614. ...
TY - CONF. T1 - Novel coumarins with improved solubility as FXIIa inhibitors. AU - Bouckaert, Charlotte. AU - Vancraeynest, Christelle. AU - Dolušić, Eduard. AU - Frédérick, Raphaël. AU - Pochet, Lionel. PY - 2013. Y1 - 2013. N2 - Background: Thrombotic diseases remain a major cause of death in industrialised countries. Anticoagulants have proven their efficacy to address these disorders. However severe bleeding complications are still reported even with the use of recently marketed drugs. Novel and safe antithrombotics are thus required.In this perspective, coagulation factor XIIa (FXIIa), a serine protease implicated in the contact phase of coagulation cascade, recently emerged as a promising target in the development of such agents. Indeed, it was demonstrated that FXII deficiency or inhibition protects against thrombosis without causing spontaneous bleeding in mice.Aim: Based on these considerations, the goal of our project is to develop novel selective FXIIa inhibitors to detail the ...
Read Fluorescence studies in environmentally benign solvents: solvation dynamics of Coumarin 102 in [BMIM][BF4], Research on Chemical Intermediates on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
A Student Researched Lab Analysis about cost effective Pd-catalyzed Coumarin Synthesis. Reaction substrates and conditions could be used in large scale.
TY - JOUR. T1 - Insight into the mode of action of coumarins as thrombin inhibitors. AU - Frédérick, Raphaël. AU - Charlier, Caroline. AU - De Ruyck, Jerome. AU - Dieu, Marc. AU - Robert, Séverine. AU - Masereel, Bernard. AU - Pochet, Lionel. PY - 2004. Y1 - 2004. M3 - Literature review. VL - 18. SP - 595. JO - Fundamental and Clinical Pharmacology. JF - Fundamental and Clinical Pharmacology. SN - 0767-3981. ER - ...
While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation has prompted the development of alternative nanomaterials-based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin-4-yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)
Coumarin (; 2H-chromen-2-one) is a fragrant organic chemical compound in the benzopyrone chemical class, although it may also be seen as a subclass of lactones. It is a natural substance found in many plants, and a colorless crystalline substance in its standard state. The name comes from a French term for the tonka bean, coumarou, one of the sources from which coumarin was first isolated as a natural product in 1820 ...
2H-Chromen-2-ones, commonly known as coumarins, are naturally occurring oxygen heterocyclic compounds which have a distinct and important place in natural and synthetic organic chemistry, as they have been found to exhibit varying degrees of biological activities, namely, antibacterial, antiviral, anticancer and anti HIV [1-3]. These have been reported to display activity against several types of animal tumors [4], prostate cancer and metastatic renal cell carcinoma [5] and have also been used as additives in food, cosmetics [6], optical brighteners [7], dispersed fluorescent and laser dyes [8].. Due to the importance of the 2H-chromen-2-ones, continuous efforts have been made to simplify the procedures for the synthesis of these compounds, which include use of Pechmann and Duisberg [9], Perkin and Henry [10], Knoevenagal [11], Reformatsky [12] and Wittig [13] reactions. Among these, the Pechmann condensation is considered to be one of the most important, as it requires simple starting ...
Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo.
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Four new coumarins (2,3-dihydroxyphellopterin, E-5-methoxytrichoclin acetate, Z-5-methoxytrichoclin acetate, and E-5-methoxytrichoclin) and three known coumarins (byakangelicol, byakangelicin, and Z-5-methoxytrichoclin) were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The chemical structures were elucidated on the basis of their spectroscopic data. The inhibitory activities of nitric oxide (NO) production in ...
Abbasi, S. and Khaledi, M. and Gholipour, A. and Heydari, R. (2017) Assessment of the Prevalence of Staphylococcus Areus in Nose of the Surgical Staff of Hajar and kashanis Hospital in 2015. Journal of Shahrekord Uuniversity of Medical Sciences, 19. Abdizadeh, T. and Kalani, M.R. and Abnous, K. and Tayarani-Najaran, Z. and Khashyarmanesh, B.Z. and Abdizadeh, R. and Ghodsi, R. and Hadizadeh, F. (2017) Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents. European Journal of Medicinal Chemistry, 132. pp. 42-62. Abedi, A. and Mortazavi, M. and Mirmosayyeb, O. and Taheri, Sh. and Afsharmoghadam, N. and Asadi-Samani, M. and Sajadieh, Sh. and Baradaran, A. (2017) Decoy Cell Viruria in Kidney Transplant Patients. Does it correlate with Renal Function? WORLD FAMILY MEDICINE, 15 (5). pp. 20-25. Abedi, E. and Khezri, S. and Abtahi, S.M. (2017) Evaluation of the chlorpromazine effect on experimental autoimmune ...
Structure and Function of XenA xycoumarin 4 and 3-(2,3-dihydroxyphenyl)-propionic acid 5 (The enzymes producing Approximately 15 × 106 tons of coal tar are and converting these two compounds are not produced worldwide every year and are the source known. Quinoline degrading P. putida strains do for condensed aromatics and N-heteroaromatics like not grow with coumarin as a sole source of carbon and energy. However, when bacteria that were have developed strategies to metabolize naturally grown with quinoline are incubated with coumarin occurring aromatic compounds and xenobiotics and 6, 3-(2-hydroxyphenyl)-propionic acid 7 accumu- as they are able to biomineralize potentially toxic latesCharacteristic reactions of coumarins are compounds, they can be exploited in the bioreme- additions to the C-3/C-4 double bond and the diation of polluted soils and Quinoline is a nucleophilic opening of the lactone group.Addi- ubiquitous, soluble, heteroaromatic pollutant with tion of a hydride and a proton to ...
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Khellol Glucoside, Psoralen, Cantharides Beetles The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. They are biosynthesized partly through the phenylpropanoid pathway and the mevalonate pathway,
Read about the chemical and physical properties of (3-Ethoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-acetic acid. Get (3-Ethoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-acetic acid molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push-pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin ...
The interaction of Eu(III) ion with 7-carboxymethoxy-4-methylcoumarin (CMMC) has been investigated using the potentiometric method in the ethanol-water mixture solvent (0.15 volume fraction). The formation of the different binary, ternary complexes is confirmed by the corresponding pH-potentiometric curves. SUPERQUAD computer program has been used for the refinement of all the calculated constants in our present study. Electroanalytical techniques have been used to confirm the formation of different binary and ternary complexes under investigation. The binding constant of the ternary complex Eu(III)-CMMC-DNA calculated by cyclic voltammetry (CV) and differential pulse (DP) was found to be 1.8 and 2.5x 105 M-1 in Tris-HCl, respectively. The changes in the current intensity have been used for the quantitative determination of DNA over a linear concentration range with LOD of 1.0-1.3 µg/ ml in 0.1 M Tris-HCl buffer.. ...
The goals of therapy are 1) stabilization with supportive treatment of the patient, 2) prevention of thrombus expansion and the formation of additional clots, and 3) reduction in size of the existing clots and restoration of perfusion. Stabilization may involve oxygen therapy, fluid therapy, and analgesia. Management should be provided based on the individual patients needs.. Anticoagulant therapy in veterinary patients consists primarily of various types of heparin. Coumarin derivatives can also be used, but will not be discussed here. Heparins enhance the inhibitory activity of AT by binding to AT, which then inactivates thrombin and factor Xa. Short molecules of heparin are better at catalyzing AT to inhibit factor Xa than to inhibit thrombin. Heparins can also cause the release of TFPI from the endothelial surface. Sodium heparin is an unfractionated heparin, and contains heparin molecules of varying sizes. It is widely available and inexpensive. Unfractionated heparin has the highest ...
Novobiocin is an antibiotic which binds to a 24 kDa fragment from the B subunit of DNA gyrase. Naturally occurring resistance arises from mutation of Arg-136 which hydrogen bonds to the coumarin ring of novobiocin. We have applied calorimetry to characterize the binding of novobiocin to wild-type and R136H mutant 24 kDa fragments. Upon mutation, the Kd increases from 32 to 1200 nM at 300 K. The enthalpy of binding is more favorable for the mutant (DeltaH degrees shifts from -12.1 to -17.5 kcal/mol), and the entropy of binding is much less favorable (TDeltaS degrees changes from -1.8 to -9.4 kcal/mol). Both of these changes are in the direction opposite to that expected if the loss of the Arg residue reduces hydrogen bonding. The change in heat capacity at constant pressure upon binding (DeltaCp) shifts from -295 to -454 cal mol-1 K-1. We also report the crystal structure, at 2.3 A resolution, of a complex between the R136H 24 kDa fragment and novobiocin. Although the change in DeltaCp often ...
Opopanax chironium is a rich source of furano- and dihydrofuranocoumarins, whose accumulation in all plant parts and especially the roots is presumably responsible for the poisonous properties of the species. The presence of two distinct chemotypes was evidenced, with the one from Sicily affording the new dihydrofuranocoumarins 5d and 5e, while extracts from the Sardinian chemotype showed powerful apoptotic activity, which was traced to the prenylated furanocoumarins heraclenin (2a) and imperatorin (2b). Despite a close structural similarity, compounds 2a and 2b induced apoptosis in Jurkat leukemia cells in mechanistically different ways.
Read about the chemical and physical properties of (6-Benzyloxy-7-methoxy-isoquinolin-1-yl)-(2-hydroxy-phenyl)-methanone. Get (6-Benzyloxy-7-methoxy-isoquinolin-1-yl)-(2-hydroxy-phenyl)-methanone molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
Structure, properties, spectra, suppliers and links for: (2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-phenyl-3-{[(2,6-|sup>3|.
Structure, properties, spectra, suppliers and links for: (1β,2α,5β,7β,8α,10α,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoy.
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The 90 kDa heat shock proteins are proving to be extraordinary cancer chemotherapeutic targets as evidenced by the fact that more than 20 clinical trials are cu...
This page contains information on the chemical Distannoxane, 1,3-diacetoxy-1,1,3,3-tetrabutyl- including: 11 synonyms/identifiers.
Supplementary MaterialsFigure S1: c1 congenic mice possess an increased proportion of GC B and Tfh cells. 4 month aged B6, c1(96-100), c1(88-100) and c1(70-100) mice were stained with FITC anti-IgM (Green), biotinylated PNA followed by 7-amino-4-methylcoumarin-3-acetic acid-conjugated streptavidin (Blue), PE anti-PD1 (Yellow) and allophycocyanin anti-CD4 (Purple). Arrows show the location of Tfh cells within the germinal center for each mouse strain. Notice the improved numbers of Tfh cells (white dots) distributed Rabbit Polyclonal to ELAV2/4 throughout the large germinal center in c1(70-100) and to a lesser degree Defactinib c1(88-100) mice. Magnification= ? 10. The level bar shows 100 m. (D) Scatter storyline showing the number of Tfh cells within GC. Each point represents the average quantity of Tfh cells per GC for an individual mouse, with 5-7 GC becoming counted per mouse. Horizontal lines show the mean of each group examined. Significance levels were determined by one-way ANOVA with ...
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... coumarins; organic acids such as citric acid and a red dye; phenolics such as phenolic acid; and anthraquinone derivatives such ...
The coumarins can undergo further reactions such as prenylation and oxidation to give multiple furanocoumarins one of which is ... Steck, Warren; Bailey, B. K. (1969). "Leaf coumarins of Angelicaarchangelica". Canadian Journal of Chemistry. 47 (13): 2425- ... "Plant coumarins. IX.* Phenolic compounds of Ferulopsis hystrix growing in Mongolia. Cytotoxic activity of 8,9- ... and hydroxylases then transform these amino acids to cinnamic acid derivatives which undergo o-hydroxylation yielding coumarins ...
Abu-Mustafa, Effat A.; Fayez, M. B. E. (1961). "Natural Coumarins. I. Marmesin and Marmesinin, Further Products from the Fruits ...
Schönberg, Alexander; Badran, Nasry; Starkowsky, Nicolas A. (1953). "Furo-chromones and -Coumarins. VII. Degradation of ...
The Kostanecki acylation is a method used in organic synthesis to form chromones or coumarins by acylation of O-hydroxyaryl ... Sethna, S. M.; Shah, N. M. (1945). "The Chemistry of Coumarins". Chemical Reviews. 36: 1-62. doi:10.1021/cr60113a001. v. ... or coumarin) Alvocidib (flavopiridol) Dimefline Flavoxate Allan-Robinson reaction Baker-Venkataraman rearrangement Gaspar, A.; ...
They consist of coumarin annulated with furan. It can also be injected and used topically. In 1947, methoxsalen was isolated ( ... Nielsen BE (1970). Coumarins of Umbelliferous plants. Copenhagen: Royal Danish School of Pharmacy. Cited by Mitchell and Rook ( ...
Nielsen, B. E. (1970). Coumarins of Umbelliferous plants. Copenhagen: Royal Danish School of Pharmacy. Cited by Mitchell and ... Schönberg, Alexander; Badran, Nasry; Starkowsky, Nicolas A. (1955). "Furo-chromones and -Coumarins. XII. Synthesis of Fraxinol ... "The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the ...
His interest in coumarins, a recently isolated compound at the time, led Bargellini to experiment with multi-component ... One hundred years later, the Bargellini reaction itself was used for the condensation of coumarins, an ironic twist to the ... Sen, Prabir K.; Biswas, Bidyut; Venkateswaran, Ramanathapuram V. (2005-12-12). "Bargellini condensation of coumarins. ...
Nigg, H. N.; Nordby, H. E.; Beier, R. C.; Dillman, A.; Macias, C.; Hansen, R. C. (1993). "Phototoxic coumarins in limes" (PDF ... "The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the ...
... the coumarins aesculetin and scopoletin; the ellagitannins are roburins A and E, grandinin, vescalagin and castalagin. Guaiacol ...
Nigg, H. N.; Nordby, H. E.; Beier, R. C.; Dillman, A.; Macias, C.; Hansen, R. C. (1993). "Phototoxic coumarins in limes" (PDF ...
Several coumarins have been isolated from the roots, including one named merrillin. The alkaloid yuehchukene has been found in ... 1989). Coumarins of Merrillia caloxylon. Phytochemistry 28(2), 657-59. Kong, Y., et al. (1988). The biochemical systematics of ...
Also many other functional heterocycles are in good yields accessible from ethyl cyanoacetate, such as 3-substituted coumarin ... V.; Dangyan, M. T. (1980). "Synthesis of functionally substituted coumarins". Chem. Heterocycl. Compounds. 15 (9): 959-960. doi ...
It also contains coumarin, so care should be taken to avoid potential drug interactions, e.g. with blood thinners. While ... and coumarin. German chamomile is used in herbal medicine for a sore stomach, skin care, irritable bowel syndrome, and as a ...
It also contains coumarins and limonoids. Cell cultures produce the coumarins umbelliferone, scopoletin, psoralen, xanthotoxin ... INIST:2179664 Steck, Warren; Bailey, B.K.; Shyluk, J.P.; Gamborg, O.L. (1971). "Coumarins and alkaloids from cell cultures of ... INIST:18469419 Srivastava, S. D.; Srivastava, S. K.; Halwe, K. (1998). "New coumarins and limonoids of Ruta graveolens". ...
... is a coumarin derivative found in the leaves of the Australian Willow (Geijera parviflora). It is a monoamine ... Lahey FN, Macleod JK (September 1967). "The coumarins of Geijera parviflora Lindl". Aust J Chem. 20 (9): 1943-55. doi:10.1071/ ...
HRAS Coumarin resistance; 122700; CYP2A6 Cousin syndrome; 260660; TBX15 Cowden syndrome; 158350; PTEN Cowden-like syndrome; ...
Coumarin Cui, WS; Tian, J; Ma, ZJ; Guo, YQ; Wang, JH; Li, X (2003). "A new isocoumarin from bark of Pellodendron chinense". ...
The chemistry of these plants has been studied, with several known and new coumarins isolated. One such coumarin from M. ... 2001). Three new coumarins from Micromelum integerrimum.[permanent dead link] Chinese Chemical Letters 12(7) 603-06.. ... Isolation and structural elucidation of new coumarins. Chemical and Pharmaceutical Bulletin - Tokyo 48(3), 334-38. He, H. P., ...
The leaves contain coumarins and sesquiterpene lactones. The sesquiterpenes are known to be costunolide, parthenolide, ... 10.1002/jps.2600700833 Coumarins and sesquiterpene lactones from Magnolia grandiflora leaves. Yang MH, Blunden G, Patel AV, ...
Coumarins from the Root of Seseli libanotis (L.) Koch. The Structure of Three New Coumarins" (PDF). Acta Chemica Scandinavica. ... doi:10.2478/s11535-012-0094-4. Lemmich, John; Shabana, Marawan (11 April 1984). "Coumarin sulphates of Seseli libanotis". ...
2008). Two new coumarins from Euonymus hamiltonianus. Chemistry of Natural Compounds 44(1) 10-12. Tantray, M. A., et al. (2009 ... A number of novel chemical compounds have been isolated from this plant, including the coumarins euonidiol and euoniside and ...
Dicoumarol Coumarin Bye, A.; King, H. K. (1970). "The biosynthesis of 4-hydroxycoumarin and dicoumarol by Aspergillus fumigatus ... 4-Hydroxycoumarin is a coumarin derivative with a hydroxy group at the 4-position. 4-Hydroxycoumarin is an important fungal ... metabolite from the precursor coumarin, and its production leads to further fermentative production of the natural ...
... is a coumarin. It found in the root of plants in the genus Scopolia such as Scopolia carniolica and Scopolia ... A similar coumarin is scoparone. Scopoletin is highly fluorescent when dissolved in DMSO or water and is regularly used as a ... Ma J; Jones SH; Hecht SM (2004). "A coumarin from Mallotus resinosus that mediates DNA cleavage". J Nat Prod. 67 (9): 1614-1616 ... Scopoletin is derived from 1,2-benzopyrones which is the core structure of coumarins formed through hydroxylation of cinnamates ...
Coumarin citrus fruits, maize. Tyrosol olive oil. Hydroxytyrosol olive oil. Oleocanthal olive oil. Oleuropein olive oil. ...
US Patent US 3399195 A. Beyerle R, Stachel A, Nitz RE, Resag K (1970). Process for the production of coumarin derivatives. US ... US Patent US 3894015 A. Beyerle R, Stachel A (1976). Piperazino substituted coumarin derivatives. US Patent US 3959281 A. ... coumarin), and basically substituted 1H,3H)-quinazoline-2-thion-4-one derivatives, having excellent coronary dilator properties ...
... originates from coumarins in the shikimate pathway; its biosynthesis is shown in the figure below. The aromatic ring ... It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of ... It exhibits the normal reactions of the lactone of coumarin, such as ring opening by alkali to give a coumarinic acid or ... does undergo substitution at the desired 6-position allowing the following synthesis of the coumarin system via a Gattermann- ...
Important representatives of this class are the coumarins. Likewise a 4-hydroxyl pyrylium compound is a γ-pyrone or pyran-4-one ...
... and Coumarins". Journal of Agricultural and Food Chemistry. 53 (6): 2009-2014. doi:10.1021/jf0484632. ISSN 0021-8561. PMID ...
Kulkarni, Manohar V.; Kulkarni, Geeta M.; Lin, Chao-Hsiung; Sun, Chung-Ming (2006). "Recent Advances in Coumarins and 1- ... B. M. Hausen; M. Schmieder (1986). "The sensitizing capacity of coumarins (I)". Contact Dermatitis. 15 (3): 157-163. doi: ... The tanning activator coumarin is known to induce thymine dimers (cyclobutane pyrimidine dimers). Other Web sites state ... correctly that: "Coumarins produce photosensitivity therefore advise the patient to avoid direct sunlight after treatment. [1] ...
Among the various coumarin laser dyes are coumarins 480, 490, 504, 521, 504T, and 521T. Coumarin tetramethyl laser dyes offer ... including coumarins. Coumarin and its derivatives are all considered phenylpropanoids. Some naturally occurring coumarin ... Coumarin was first synthesized in 1868 by the English chemist William Henry Perkin. Coumarin has been an integral part of the ... Coumarin is found naturally also in many edible plants such as strawberries, black currants, apricots, and cherries. Coumarin ...
... coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including ... Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, ... Coumarin as an Immunomodulator (G. Zlabinger).. Mode of Action of Coumarin in the Treatment of Thermal Injuries (N. Piller).. ... Analysis of Coumarins (D. Bogan, et al.).. Suggested Modes of Action of Coumarins and Some Comments on their Significance (R. ...
Coumarin Hydroxy Group Terpenoid Acetone Extract Axial Orientation V. L. Komarov Botanical Institute, Academy of Sciences of ...
Coumarin Hydroxy Group CD3OD Bathochromic Shift Xanthone All-Union Scientific-Research Institute of Medicinal Plants, Moscow. ... N. Sheinker, and A. A. Savina, The Spectra and Structure of Coumarins, Chromanes, and Xanthones [in Russian], Moscow (1975). ...
Other names: 2H-1-Benzopyran-2-one; cis-o-Coumarinic acid lactone; o-Hydroxycinnamic acid lactone; Benzo-«alpha»-pyrone; Coumarinic anhydride; Rattex; Tonka bean camphor; 1,2-Benzopyrone; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, «delta»-lactone; 2H-Benzo[b]pyran-2-one; o-Hydroxycinnamic lactone; Cinnamic acid, o-hydroxy-, «delta»-lactone; Cumarin; 2-Oxo-1,2-benzopyran; 2H-1-Benzopyran, 2-oxo-; o-Hydroxyzimtsaure-lacton; Kumarin; NCI C07103; NSC 8774; 2H-Chromen-2-one ...
All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. ... Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being ... In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for ... Evaluation of Halogenated Coumarins for Antimosquito Properties. Venugopala K. Narayanaswamy,1,2 Raquel M. Gleiser,3 Kabange ...
All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. ... Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being ... In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for ... Mortality of Anopheles arabiensis larvae exposed to coumarins and halogenated coumarins at 4 g/mL and their negative (acetone) ...
The fluorescence of coumarins, such as 7-hydroxycoumarin, is widely used as a research tool in polymer science. Coumarins are ... Several natural and synthetic coumarins and derivatives, such as coumarin glycosides, possess potent biological activities. ... Coumarin derivatives are found in antibiotic, antimitotic, immunomodulating, antiviral, anticancer, anti-inflammatory, ... Learn More about Coumarins
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coumarin synonyms, coumarin pronunciation, coumarin translation, English dictionary definition of coumarin. n. A fragrant ... Coumarin - definition of coumarin by The Free Dictionary https://www.thefreedictionary.com/coumarin ... coumarin. Also found in: Medical, Encyclopedia, Wikipedia. cou·ma·rin. (ko͞o′mər-ĭn). n.. A fragrant crystalline compound, C9H6 ... coumarin. (ˈkuːmərɪn) or cumarin. n. (Elements & Compounds) a white vanilla-scented crystalline ester, used in perfumes and ...
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coumarin definition: a toxic, white crystalline substance, CHO, with the odor of vanilla, obtained from the tonka bean and ... Coumarin and its derivatives are widely used in perfumes, as anticoagulants, and as rodenticides. Chemical formula: C9H6O2. ... coumarin. cou·ma·rin. a toxic, white crystalline substance, CHO, with the odor of vanilla, obtained from the tonka bean and ... Origin of coumarin. French coumarine from coumarou tonka bean tree from Spanish coumarú from Portuguese cumaru from Tupí cumarú ...
The Panel concludes that there is evidence for a risk of interaction between glucosamine and coumarin anticoagulants in some ... The evidence for an interaction between glucosamine and coumarin anticoagulants is strengthened by the observation that in the ... There is insufficient information to conclude on a mechanism for an interaction between glucosamine and coumarin anticoagulants ... Nutrition and Allergies to provide a scientific statement on the safety of glucosamine for patients receiving coumarin ...
Testing Status of Methyl coumarin 10136-L. CASRN: 92-48-8. Formula: C10-H8-O2. Synonyms/Common Names. *6-Methyl-2H-1-benzopyran ...
This page features an image of a coumarin-diclofenac mixture. ... A naturally occurring compound found in many plants, coumarin ...
There are many different coumarin derivatives, including those that are naturally found and those that are synthesized. Natural ... Coumarin derivatives have been shown to possess anti-inflammatory and anticoagulant properties, but they can also be toxic in ... Although coumarin itself does not function as an anticoagulant - a substance that prevents blood clotting - it can be ... Coumarin derivatives are widely used in pharmaceutical and commercial applications due to their health properties. A compound ...
Coumarins consist of a large class of phenolic substances found in plants. Different pharmacologic effects of coumarins were ... One of these effects is cytotoxicity and apoptosis induction in cancerous cells by coumarins. In this chapter, the cytotoxic ... so regulation of Mcl-1 expression by coumarins could be one of the mechanisms of CLL chemotherapy. ... activity of coumarins and their role in Mcl-1 regulation are discussed. ...
7-(Diethylamino)coumarin-3-carbohydrazide, derivatizing agent for carboxylic acid detection (ab145377). ...
Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ... In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. ... In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids ... Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Antonella Fais 1,* , Marcella Corda 1. ...
Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to ... Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to ... What is the role of coumarins in deep venous thrombosis (DVT) prophylaxis for patients undergoing orthopedic surgery?. Updated ... Coumarins produce their anticoagulant effect by inhibiting the carboxylation necessary for biologic activity. ...
A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their ... Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins Q. Li, L. Wei, J. Zhang, G ... A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their ... These results demonstrated that the combination of chitosan and coumarins improved the antioxidant activity of chitosan ...
Coumarin and its derivatives are all considered phenylpropanoids. Coumarin toxicity. Coumarin is often found in tobacco ... The biosynthesis of coumarin in plants is via hydroxylation, glycolysis and cyclization of cinnamic acid. Coumarin can be ... Coumarin is a chemical compound; a toxin found in many plants, notably in high concentration in the tonka bean, woodruff, and ... Coumarin was banned as a food additive in the United States in 1978. OSHA considers this compound to be only a lung-specific ...
3-bromoacetyl coumarin, 3-2-bromoacetyl-2h-chromen-2-one, 3-2-bromoacetyl chromen-2-one, 3-bromoacetylcoumarin, 3-bromoacetyl- ... 3-bromoacetyl coumarin, 3-2-bromoacetyl-2h-chromen-2-one, 3-2-bromoacetyl chromen-2-one, 3-bromoacetylcoumarin, 3-bromoacetyl- ... 3-bromoacetyl coumarin, 3-2-bromoacetyl-2h-chromen-2-one, 3-2-bromoacetyl chromen-2-one, 3-bromoacetylcoumarin, 3-bromoacetyl- ... 2h-chromen-2-one, 2h-1-benzopyran-2-one, 3-bromoacetyl, pubchem8670, rarechem ab ka k003, 3-bromoacetyl coumarin, 3-2- ...
Coumarin Necrosis Associated with Hereditary Protein C Deficiency Annals of Internal Medicine; 101 (1): 59-60 ... KOCH-WESER J. Coumarin Necrosis. Ann Intern Med. 1968;68:1365-1367. doi: 10.7326/0003-4819-68-6-1365 ... Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign ... Only one serious complication remains poorly understood: coumarin necrosis of skin and subcutaneous tissue. Widely reported in ...
Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8′-O-acetyl-asacoumarin ... The genus Ferula is mainly known for the occurrence of coumarins, sesquiterpenes and sesquiterpene coumarins [9,10,11,12,13,14 ... it concerns 4-hydroxy-coumarins prenylated in position 3. Since this type of terpenyl coumarins has not been found in the ... The 1H- and 13C-NMR spectra of compounds 1-6 (Figure 1) all showed the typical signals of a coumarin moiety, e.g., for compound ...
TOXICITY OF COUMARIN. L. W. Hazleton, T. W. Tusing, B. R. Zeitlin, R. Thiessen and H. K. Murer ... TOXICITY OF COUMARIN. L. W. Hazleton, T. W. Tusing, B. R. Zeitlin, R. Thiessen and H. K. Murer ... TOXICITY OF COUMARIN. L. W. Hazleton, T. W. Tusing, B. R. Zeitlin, R. Thiessen and H. K. Murer ... Coumarin incorporated in the diet of male and femal albino rats for a 90-day period at levels of 50 ppm, 250 ppm, and 2500 ppm ...
Coumarin was rapidly metabolized after oral administration and more than 95% of the 7OHC formed was excret … ... formation of 7-hydroxycoumarin by measuring the urinary excretion of the metabolite in humans after administering 5 mg coumarin ... Interindividual variability of coumarin 7-hydroxylation in healthy volunteers Pharmacogenetics. 1992 Oct;2(5):227-33. doi: ... Coumarin was rapidly metabolized after oral administration and more than 95% of the 7OHC formed was excreted in 4 h. The total ...
Coumarins explanation free. What is Coumarins? Meaning of Coumarins medical term. What does Coumarins mean? ... Looking for online definition of Coumarins in the Medical Dictionary? ... redirected from Coumarins). Also found in: Dictionary, Encyclopedia.. Related to Coumarins: Tannins, Flavonoids coumarin. [koo´ ... Coumarins , definition of Coumarins by Medical dictionary https://medical-dictionary.thefreedictionary.com/Coumarins ...
Coumarin Coumarin 540 CAS Number: 38215-36-0 INQUIRY Coumarin 314 CAS Number: 55804-66-5 INQUIRY Coumarin 343 azide CAS Number ... Boc Sciences offers Coumarin in bulk, please inquire us to get a quote for Coumarin. ... 41044-12-6 INQUIRY Coumarin 334 CAS Number: 55804-67-6 INQUIRY Coumarin 343 CAS Number: 55804-65-4 INQUIRY Coumarine 545T CAS ... Coumarin 1 CAS Number: 91- Resources About Us Contact Us 946123-11-1 Purity: NMR 1H, HPLC-MS (95%) INQUIRY 62935-72-2 INQUIRY ...
Both types can contain coumarin, a natural flavoring found in plants. Studies have linked high coumarin intake to liver damage ... Levels Of Coumarin In Cassia Cinnamon Vary Greatly Even In Bark From The Same Tree. by Sam Savage ... They found that coumarin levels varied widely among different bark samples of Cassia cinnamon. Therefore they analyzed cassia ... A "huge" variation exists in the amounts of coumarin in bark samples of cassia cinnamon from trees growing in Indonesia, ...
A set of already reported antifungal bioactive coumarin and some well-known physical descriptors have been selected and using ... relation between some important thermodynamic and physico-chemical properties of coumarin compounds and their biological ... Modeling of thermodynamic and physico-chemical properties of coumarins bioactivity against Candida albicans using a Levenberg- ... A set of already reported antifungal bioactive coumarin and some well-known physical descriptors have been selected and using ...
  • History of the Development and Applications of Coumarin and Coumarin-related Compounds (I. Weinmann). (wiley.com)
  • Coumarins are a group of plant-derived polyphenolic compounds. (sigmaaldrich.com)
  • 17-19) While the phytochemical studies and bioactivity studies were mostly conducted with the coumarin compounds of the genus, we wanted to examine the flavonoid content of Heracleum pastinaca Fenzl (Figure 1), which is a tiny rare endemic plant mainly distributed in the inner and southwest region of Anatolia. (thefreedictionary.com)
  • The anticoagulant activity of coumarin derivatives can be toxic to humans if these compounds are ingested in excessive amounts. (wisegeek.com)
  • Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC 50 values of these compounds were measured. (mdpi.com)
  • Coumarin is often found in tobacco products and artificial vanilla substitutes, though it has been banned as a food additive in numerous countries since the mid- 20th century because it is moderately toxic to the liver and kidneys, with an LD 50 of 275 mg/kg - low compared to related compounds. (wikidoc.org)
  • In this study, by using a Levenberg--Marquardt (LM) neural network (the fastest of the training algorithms), the -relation between some important thermodynamic and physico-chemical properties of coumarin compounds and their biological activities (tested against Candida albicans ) has been evaluated. (dovepress.com)
  • A set of already reported antifungal bioactive coumarin and some well-known physical descriptors have been selected and using LM training algorithm the best architecture of neural model has been designed for forecasting the new bioactive compounds. (dovepress.com)
  • 1 ThIS family of compounds serve as an important model for the advanced design and synthesis of more active analogous coumarins, since natural compounds possess potent antioxidants and radical-scavenging properties as reportedin various experimental models. (scielo.org.za)
  • Coumarin heterocycles have been found to be very useful compounds for different types of activities. (scielo.org.za)
  • The two new compounds were established as 7-hydroxy-6-methoxy-3,8-bis(3-methyl-2-butenyl) coumarin (1) and 7-hydroxy-6-methoxy-3-(3-methyl-2-butenyl) coumarin (2), on the basis of 1D and 2D NMR techniques. (semanticscholar.org)
  • Coumarins are the main bioactive compounds in Peucedanum praeruptorum Dunn, a common Chinese herbal medicine. (frontiersin.org)
  • The chemical structures of new prenylated coumarins (1-3) were elucidated by means of comprehensive spectral analyses and the known compounds (4-12) were determined by means of comparing their experimental spectral data with those described data in the literatures. (physiciansweekly.com)
  • In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative.These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9.However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. (nih.gov)
  • In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. (nih.gov)
  • However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. (nih.gov)
  • Coumarin compounds constitute a class of secondary metabolites widely found in plants. (scielo.br)
  • 3-7 Coumarin compounds are usually employed as additive in dyes and sprays as well as in aromatization of foods. (scielo.br)
  • Coumarins (2H-chromen-2-ones) are heterocyclic compounds of wide scientific interest due to their important biological and pharmaceutical properties such as antitumor, antioxidant, anti-inflammatory and antimicrobial activities as well as enzymatic inhibitors related to neurodegenerative diseases. (eurekaselect.com)
  • The principle is similar to that of dye lasers, which also amplify light using dissolved organic molecules--not proteins, but compounds such as coumarin dyes, derived from substances in grasses that smell like freshly mowed hay. (thefreedictionary.com)
  • The aim of this study was to synthesise a series of compounds out of pharmacophoric groups of donepezil and coumarin that will be able to inhibit both cholinesterases and MAO B. Four series of 5 compounds per series were synthesised. (uwc.ac.za)
  • The first series of compounds consisted of the coumarin moiety to which a 1,4-dibromo benzene moiety was attached. (uwc.ac.za)
  • The third series represented the coumarin moiety to which bromobenzyl-piperazine was attached and in the last series were compounds similar in structure to series 1 with an unsubstituted benzyl moiety as opposed to the dibromobenzyl moiety. (uwc.ac.za)
  • Some naturally occurring coumarin derivatives include umbelliferone (7-hydroxycoumarin), aesculetin (6,7-dihydroxycoumarin), herniarin (7-methoxycoumarin), psoralen and imperatorin. (wikipedia.org)
  • Coumarin and its derivatives are widely used in perfumes, as anticoagulants, and as rodenticides. (yourdictionary.com)
  • The European Food Safety Authority (EFSA) asked the Panel on Dietetic Products, Nutrition and Allergies to provide a scientific statement on the safety of glucosamine for patients receiving coumarin anticoagulants. (europa.eu)
  • More than 40 case reports have been collected by drug-monitoring agencies that showed in some patients being prescribed coumarin anticoagulants, especially warfarin, that the International Normalised Ratio (INR) increased after they began taking glucosamine, which indicated an increase in the coagulation time. (europa.eu)
  • The evidence for an interaction between glucosamine and coumarin anticoagulants is strengthened by the observation that in the majority of cases the INR began to fall to normal values when glucosamine intake was discontinued. (europa.eu)
  • There is insufficient information to conclude on a mechanism for an interaction between glucosamine and coumarin anticoagulants. (europa.eu)
  • The Panel concludes that there is evidence for a risk of interaction between glucosamine and coumarin anticoagulants in some individuals that could lead to an increased INR, and, that this could further lead to haemorrhage. (europa.eu)
  • Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon. (unboundmedicine.com)
  • Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently prescribed oral anticoagulants to treat and prevent thromboembolism. (unboundmedicine.com)
  • Background and Purpose- It remains undetermined whether the use of coumarin anticoagulants associates with cerebral microbleeds in the general population. (empr.com)
  • Today, the most commonly used anticoagulants are heparin and coumarin. (discoveriesinmedicine.com)
  • The main anticoagulants used today, are heparin, which is injected, and coumarin, which is taken orally (by mouth). (discoveriesinmedicine.com)
  • The fluorescence of coumarins, such as 7-hydroxycoumarin, is widely used as a research tool in polymer science. (sigmaaldrich.com)
  • Although absorption of UV-radiation and light is a unifying theme among these π-expanded coumarins, the fluorescence properties strongly depend on the structure. (rsc.org)
  • Photophysical advantages of π-expanded coumarins have been already utilized in fluorescent probes and two-photon excited fluorescence microscopy. (rsc.org)
  • The use of fluorescence spectroscopy makes the understanding of the behavior of the systems studied when in the presence of different environments being extremely important for the identification and characterization of coumarin in different pharmaceutical formulations. (scielo.br)
  • This paper discusses the sensitized fluorescence of coumarin-30 in nanoparticles self-organized from complexes of phenylbenzoyltrifluoroacetone and 1, 10-phenanthroline with ions of the lanthanides, yttrium, aluminum, and scandium in water-alcohol solutions. (osapublishing.org)
  • Samanta, Anunay 2005-09-01 00:00:00 The steady-state and time-resolved fluorescence behavior of Coumarin 102 (C-102) has been investigated in a ionic liquid at room temperature, 1-buty1-3-methylimidazolium tetrafluoroborate, abbreviated here as [BMIM][BF4]. (deepdyve.com)
  • Warfarin is a synthetic coumarin analogue (known as Coumadin) that is used as an anticoagulant and is commercially available in the market with a trade name Coumadin. (hindawi.com)
  • this family includes: brodifacoum bromadiolone difenacoum auraptene ensaculin phenprocoumon (Marcoumar) PSB-SB-487 PSB-SB-1202 Scopoletin can be isolated from the bark of Shorea pinanga warfarin (Coumadin) Coumarin is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. (wikipedia.org)
  • Warfarin and other coumarin derivatives function as pesticides by causing uncontrolled hemorrhaging in the target animal. (wisegeek.com)
  • Warfarin 33 and aceno-comarol, 34 which are coumarin derivatives, exhibit anticoagulant activity. (scielo.org.za)
  • Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. (wiley.com)
  • The coumarin derivative pachyrrhizine, a compound from tubers of Neorautanenia mitis , showed larvicidal and adulticidal activities against Anopheles gambiae and Culex quinquefasciatus Say that were comparable to deltamethrin and alpha-cypermethrin, two standard mosquitocides [ 20 ]. (hindawi.com)
  • Coumarin (/ˈkuːmərɪn/) or 2H-chromen-2-one is an aromatic organic chemical compound with formula C 9H 6O 2. (wikipedia.org)
  • The trouble is that grocery store cinnamon, a spice known as cassia cinnamon, contains a compound called coumarin , which has been linked to an increased risk of liver disease when consumed in excess (more than a teaspoon per day). (thefreedictionary.com)
  • A naturally occurring compound found in many plants, coumarin is commonly used in cosmetics, perfumes, and tobacco products. (fsu.edu)
  • A compound found naturally in plants such as tonka beans, cinnamon, sweet clover, and vanilla grass, coumarin has several chemical derivatives that can be found naturally or synthesized in the laboratory. (wisegeek.com)
  • rats and other rodents largely metabolize it to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. (wikidoc.org)
  • Coumarin is a natural compound abundant in plant-based foods such as citrus fruits, tomatoes, vegetables and green tea. (cambridge.org)
  • Coumarin is a naturally occurring sweet-smelling compound found in many plants, including cinnamon and tonka beans. (gc.ca)
  • Coumarin was used as a model compound because its toxicity depends on bioactivation by P450 enzymes. (tudelft.nl)
  • The clotting factor in prothrombin turned out to be dicumarol, a coumarin (a fragrant organic substance often extracted from tonka beans) compound that had originally been synthesized in an impure form in 1903. (discoveriesinmedicine.com)
  • Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in the treatment of lymphedema and different types of cancer. (aspetjournals.org)
  • Several previous pharmacokinetic studies of coumarin have been performed in humans, which revealed extensive first-pass metabolism of the compound. (aspetjournals.org)
  • In this study, we report the effect of the various cell culture medium components on the preferential cytotoxicity of our lead isoprenylated coumarin compound against the pancreatic adenocarcinoma cell line PANC-1. (jcancer.org)
  • We report a new coumarin compound, termed DCH, that effectively combats MRSA in vitro and in vivo and exhibits potent antibiofilm activity without detectable resistance. (sciencemag.org)
  • Coumarin is a fragrant organic compound that is of importance in perfumery, medicines, and dyes. (stkate.edu)
  • Coumarin is a compound of natural source that has shown some MAO inhibitory activity. (uwc.ac.za)
  • The study confirmed that cassia cinnamon has the highest levels of coumarin, while Ceylon had the lowest levels. (redorbit.com)
  • Health Canada (HC) determined that the levels of coumarin observed in this survey are not expected to pose a concern to human health, therefore there were no follow-up actions resulting from this survey. (gc.ca)
  • Cured deer's tongue leaves contain relatively high levels of coumarin and lower amounts of o -HCA glucosides. (unl.edu)
  • And studies have discovered that high levels of coumarin can cause liver damage in sensitive people. (thefreedictionary.com)
  • The Pechmann condensation provides another synthesis of coumarin and its derivatives. (wikidoc.org)
  • 2 The synthesis of coumarin and its derivatives have attracted considerable attention from organic and medicinal chemists for many years, as large numbers of natural products contain this heterocyclic nucleus. (scielo.org.za)
  • Coumarin derivatives have been shown to possess anti-inflammatory and anticoagulant properties, but they can also be toxic in high amounts and are sometimes used as rodenticides. (wisegeek.com)
  • Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents. (thefreedictionary.com)
  • The coumarin derivatives possess a broad spectrum of biological activities such as, antifungal, 10 antibacterial, 11 anti-inflammatory, 12 antiproliferative, 13 antitumor, 14 antiviral, 15 antioxidant, 16 anticoagulant, 17 anticancer 18 and anti-HIV 19 activities. (scielo.org.za)
  • Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis. (physiciansweekly.com)
  • All isolated prenylated coumarins were assessed for their anti-inflammatory effects together with anti-HIV activities in vitro. (physiciansweekly.com)
  • These findings indicate that the isolation and identification of these prenylated coumarins with pronounced anti-inflammatory effects as well as anti-HIV activities separated from the stems of C. lenis could be of great significance to the development of new anti-inflammatory and anti-HIV agents and their potential applications in the pharmaceutical industry. (physiciansweekly.com)
  • Coumarins possess diverse biological and pharmaceutical properties, including anti-edema, anti-inflammatory and anti-tumour activities ( Hoult and Paya, 1996 ). (scialert.net)
  • Several natural and synthetic coumarins and derivatives, such as coumarin glycosides, possess potent biological activities. (sigmaaldrich.com)
  • Coumarin Glycosides from Edgeworthia chrysantha . (springer.com)
  • Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity. (semanticscholar.org)
  • Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against. (srce.hr)
  • MANOJKUMAR P, RAVI TK, GOPALAKRISHNAN G. Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells. (srce.hr)
  • The present study was designed to evaluate the effects of a series of natural coumarins on ethoxyresorufin O-dealkylase (EROD) and pentoxyresorufin O-dealkylase (PROD) activities in vitro using hepatic tissues from SENCAR mice. (nih.gov)
  • In this study, we investigated whether a hepatic in vitro system with improved metabolic competence enhances the predictability for coumarin-induced in vivo toxicity by using a toxicogenomics approach. (tudelft.nl)
  • Finn, G.J., Creaven, B. and Egan, D.A. (2001) Study of the in vitro cytotoxic potential of natural and synthetic coumarin derivatives using human normal and neoplastic skin cell lines. (scirp.org)
  • Prenylated coumarins 1-12 displayed remarkable inhibitory effects against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with the IC values which are comparable to hydrocortisone. (physiciansweekly.com)
  • In this study, we designed and synthesized a novel coumarin derivative (C3007) for evaluating its in vitro and in vivo anti-SVCV effects. (medworm.com)
  • Zhang H, Zhou R, Jun M, Bacay AF, Eyring K, Webb A, Carrico-Moniz D. Identification of the Factors Responsible for the Selective in vitro Cytotoxic Activity of Isoprenylated Coumarin Derivatives under Nutrient-deprived Conditions. (jcancer.org)
  • A series of coumarin and pyranocoumarin analogues were evaluated in vitro for antiviral efficacy against measles virus (MV), strain Chicago. (usu.edu)
  • Other plants with substantial coumarin content include cassia cinnamon (Cinnamomum cassia), not to be confused with true cinnamon (Cinnamomum verum), which contains little coumarin, deertongue (Carphephorus odoratissimus), tilo (Justicia pectoralis), mullein (genus Verbascum), and in many cherry blossom tree varieties (of the genus Prunus). (wikipedia.org)
  • Cinnamon contains a substance called coumarin , which works similar to a blood thinner. (thefreedictionary.com)
  • European health agencies have warned against consuming high amounts of cassia bark, one of the four species of cinnamon , because of its coumarin content. (wikidoc.org)
  • A "huge" variation exists in the amounts of coumarin in bark samples of cassia cinnamon from trees growing in Indonesia, scientists are reporting in a new study. (redorbit.com)
  • They found that coumarin levels varied widely among different bark samples of Cassia cinnamon. (redorbit.com)
  • On average, cassia cinnamon powder contained up to 63 times more coumarin than Ceylon cinnamon powder and cassia cinnamon sticks contained 18 times more coumarin than Ceylon sticks. (redorbit.com)
  • Further research is necessary to identify factors influencing the coumarin levels in cassia cinnamon and to possibly allow the harvesting of cassia cinnamon with low coumarin levels in the future," the report notes. (redorbit.com)
  • The CFIA considered it important to examine coumarin levels in commonly available ground cinnamon, cinnamon-containing products and licorice flavoured products to ensure that these are safe for consumption. (gc.ca)
  • The main objectives of this targeted survey were to generate further baseline surveillance data on the level of coumarin in ground cinnamon, cinnamon-containing products and licorice flavoured products on the Canadian retail market, and to compare the presence of coumarin in foods targeted in this survey to previous targeted surveys and scientific literature. (gc.ca)
  • High coumarin concentrations can be found in Cassia cinnamon (also known as true cinnamon) and Saigon cinnamon, whereas the Ceylon variety typically contains only traces. (gc.ca)
  • What Are the Dangers of Coumarin in Cassia Cinnamon? (sfgate.com)
  • Despite this broad acceptance, cassia cinnamon -- the type eaten most often in North America -- contains a substance called coumarin that can be dangerous when consumed in large quantities. (sfgate.com)
  • http://healthyeating.sfgate.com/dangers-coumarin-cassia-cinnamon-11595.html. (sfgate.com)
  • Shortly thereafter, his early lab experiments with highly potentized cinnamic aldehyde and coumarin (a variety of cinnamon) proved capable of immunizing chicken embryos from Newcastle disease virus and later was found to be effective against avian flu H9, Sendai virus, and herpes simplex 1. (thefreedictionary.com)
  • 2002/Nr 4] Quantitative determination of coumarins, flavonoids and chlorogenic acid in the. (ptfarm.pl)
  • Quantitative determination of coumarins, flavonoids and chlorogenic acid in the leaves and underground parts of some species of genus Scopolia JACQ. (ptfarm.pl)
  • Substituted pyrazolones and thiazoles reacted with 4-hydroxy coumarin to give pyrazolones and methyl thiazoles related coumarin derivatives. (scielo.org.za)
  • 28 Bucumolol, 29 Chromonar, 30 Folescutol and 4-methyl umbelliferone 31 are coumarin derivatives and are clinically used as antiarrhythmic, 32 vasodilator, 30 capillary and antispectively agents. (scielo.org.za)
  • 39 We report herein the design and synthesis of pyrazolone and methyl thiazole related coumarins derivatives with significant biological importance. (scielo.org.za)
  • Two new coumarins, 6-hydroxy-7-methyl-3-(4′-methoxyphenyl)-coumarin ( 1 ) and 6-hydroxy-5-methoxy-7-methyl-3-(4′-methoxyphenyl)-coumarin ( 2 ), together with five known coumarins ( 3-7 ), were isolated from the leaves of Nicotiana tabacum. (springer.com)
  • When sweet clover interacts with fungi and becomes moldy, it undergoes a chemical change that causes the coumarin in the plant to transform into bishydroxycoumarin. (wisegeek.com)
  • The anticoagulant properties of coumarin derivatives such as dicoumarol were first discovered in 1939 from evidence that cattle in North America that had been fed with sweet clover were suffering from hemorrhaging, or bleeding. (wisegeek.com)
  • The Chemistry and Occurrence of Coumarins (G. Keating & R. O'Kennedy). (wiley.com)
  • The genus Ferula is mainly known for the occurrence of coumarins, sesquiterpenes and sesquiterpene coumarins [ 9 , 10 , 11 , 12 , 13 , 14 ]. (mdpi.com)
  • In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. (mdpi.com)
  • Michaelis-Menten, competitive inhibition, and site-directed mutagenesis studies identified exosite 2 as the site of binding for the most potent sulfated coumarin. (sdsc.edu)
  • Antithrombin inactivation of thrombin was impaired in the presence of the sulfated coumarins suggesting that allosteric partial inhibition arises from catalytic dysfunction of the active site. (sdsc.edu)
  • Two new coumarins (1) and (2), along with seven known coumarins 3-9, were isolated from the leaves and stems of Coriarianepalensis Wall. (semanticscholar.org)
  • Several naturally occurring coumarins were also potent inhibitors of hepatic PROD activity, including imperatorin, bergamottin, isopimpinellin, and angelicin. (nih.gov)
  • The current data suggest that certain naturally occurring coumarins, to which humans are exposed in the diet, are potent modulators of cytochrome P450. (nih.gov)
  • Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. (hindawi.com)
  • In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis , a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. (hindawi.com)
  • Three of the active drugs were propyl coumarin analogues (2a, 7 and 8), two were dipyranone or chromeno-coumarins (9 and 10), and one was a benzotripyranone with a coumarin nucleus (18). (usu.edu)
  • The Potential Role of Coumarins in the Therapy of Prostate Cancer (J. Mohler, et al. (wiley.com)
  • What is the role of coumarins in deep venous thrombosis (DVT) prophylaxis for patients undergoing orthopedic surgery? (medscape.com)
  • Coumarin (CAS 588676-07-7) Market Research Report 2018 aims at providing comprehensive data on coumarin market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • Coumarin (CAS 588676-07-7) Market Research Report 2018 contents were worked out and placed on the website in February, 2018. (marketpublishers.com)
  • Please note that Coumarin (CAS 588676-07-7) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • In the present review we report the different synthetic methods used in the preparation of coumarin derivatives exploited in the last ten years (from 2008 to 2018), regarding the research demand for new structural scaffolds. (eurekaselect.com)
  • More important, cassia contains coumarin. (sfgate.com)
  • Coumarin contributes a pleasant note to many natural flavorings, including vanilla, but it primarily occurs in cassia. (sfgate.com)
  • It has been shown that the expression of Mcl-1 in CLL is significantly associated with a failure to achieve complete remission following cytotoxic therapy, so regulation of Mcl-1 expression by coumarins could be one of the mechanisms of CLL chemotherapy. (intechopen.com)
  • In this chapter, the cytotoxic activity of coumarins and their role in Mcl-1 regulation are discussed. (intechopen.com)
  • Cytotoxic properties of three isolated coumarin-hemiterpene ether derivatives from Artemisia armeniaca Lam', Iranian Journal of Pharmaceutical Research , 16(1), pp. 221-229. (ac.ir)
  • Sharma, S. Advances in synthesis and potentially bioactive of coumarin derivatives. (eurekaselect.com)
  • Coumarin was first isolated from tonka beans in 1820 by A. Vogel of Munich, who initially mistook it for benzoic acid. (wikipedia.org)
  • Smyth, W.F. A study of the antimicrobial activity of selected naturally occurring and synthetic coumarins. (eurekaselect.com)
  • Coumarins (2 H -1-benzopyran-2-one) are a class of phenolic substances found as secondary metabolites from plants, bacteria, and fungi, widely used as additives in food, perfumes, cosmetics, pharmaceuticals, optical brighteners, and dispersed fluorescent. (hindawi.com)
  • Coumarin derivatives are widely used in pharmaceutical and commercial applications due to their health properties. (wisegeek.com)
  • Further, their total coumarin content varied widely and could easily exceed the European Food Safety Authority's guideline of 0.1 milligrams per day per kilogram of body weight. (sfgate.com)
  • Psoralen: many furocoumarins have a furan band fused with a coumarin nucleus and are derivatives of psoralen. (silt3.com)
  • A study has been made of a novel fluorescent and phosphorescent label 6-coumarinsulphonyl chloride (6-CSCl) based an the coumarin nucleus with a reactive group similar to dansyl chloride. (lboro.ac.uk)
  • Synthesis of the labels with substituents at the 4 and 7 position of the coumarin nucleus were carried out. (lboro.ac.uk)
  • A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. (rsc.org)
  • These results demonstrated that the combination of chitosan and coumarins improved the antioxidant activity of chitosan obviously, and the antioxidants or free radical scavengers based on natural polymers and coumarins showed potential applications. (rsc.org)
  • The novel coumarin derivatives (2,3,4,5,6,7) have been synthesized from the reaction of o-acetyloxy benzoic acid with thionyl chloride yielding 2-acetoxy benzoyl chloride, which on further treatment with ethylacetoacetate gave 4-hydroxycoumarin. (scielo.org.za)
  • Esculin, a fluorescent coumarin glucoside, is recognized by Suc transporters, including AtSUC2, which loads it into the phloem for translocation to sink tissues. (plantphysiol.org)
  • Absolute Mag™ Amine Dextran Magnetic Particles, Fluorescent Coumarin, 35 nm (Cat# WHM-P007) are superparamagnetic iron oxide nanoparticles with a dextran coating. (cd-bioparticles.com)
  • Mazaahir Kidwai, Roona Poddar, Arti Jain, Rakesh Kumar and Pratibha M. Luthra, "Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents", Mini-Reviews in Organic Chemistry (2015) 12: 24. (eurekaselect.com)
  • citation needed] In humans, the enzyme encoded by the gene UGT1A8 has glucuronidase activity with many substrates, including coumarins. (wikipedia.org)
  • A test designed to estimate the extent and rate of formation of 7-hydroxycoumarin by measuring the urinary excretion of the metabolite in humans after administering 5 mg coumarin was developed. (nih.gov)
  • Coumarins consist of a large class of phenolic substances found in plants. (intechopen.com)
  • Natural coumarins are known for their several pharmacological properties and have been recently reviewed by Venugopala et al. (hindawi.com)
  • Although coumarin itself does not function as an anticoagulant - a substance that prevents blood clotting - it can be chemically modified through natural or artificial processes to do so. (wisegeek.com)
  • Both types can contain coumarin, a natural flavoring found in plants. (redorbit.com)
  • With these other two reviews to hand, the reader will have immediate access to every plant coumarin ever known and should readily be able to determine, for example, if a coumarin just isolated is indeed a new natural plant product. (springer.com)
  • In plants, coumarin derivatives are present in significant quantities and more than 1300 coumarins were identified from natural sources. (scielo.org.za)
  • Furthermore, experiments using a two-stage incubation assay revealed that coriandrin, imperatorin, ostruthin, and several other natural coumarins inactivated hepatic EROD activity (i.e., predominantly cytochrome P450 1A1-mediated) and that isopimpinellin inactivated hepatic PROD activity (i.e., predominantly cytochrome P450 2B1-mediated). (nih.gov)
  • Hoult, J.R. and Paya, M. (1996) Pharmacological and biochemical actions of simple coumarins natural products with therapeutic potential. (scirp.org)
  • Also Coumarin market reports analyses market by different segments, companies, regions and countries over the forecast period 2017 to 2022. (beforeitsnews.com)
  • Analysis of structure-activity relationship revealed that the presence of bromo group at 7-postion of the coumarin moiety along with the 4-chlorophenyl group at position-6 of the pyrimidine ring is critical for antimicrobial activity against Gram-positive bacteria, Gram negative bacteria and fungi. (ajol.info)
  • The second series represented the coumarin moiety to which a piperidine (donepezil moiety shown to confer cholinesterase inhibitory property) was attached. (uwc.ac.za)
  • Molecular modelling of Cp 9 showed that the coumarin core was located in the PAS region of AChE while the benzyl-piperidine moiety was situated in the CAS region of the enzyme. (uwc.ac.za)
  • Coumarins produce their anticoagulant effect by inhibiting the carboxylation necessary for biologic activity. (medscape.com)
  • Pulmonary coumarin hydroxylase activity was greater in DBA than in BALB/c mice but the severity of BHT-induced lung injury was similar. (curehunter.com)
  • Pre-treatment with pyrazole, which exacerbated BHT-induced lung injury, did not affect pulmonary coumarin hydroxylase or 4-nitrophenol hydroxylase activity but increased that of PROD. (curehunter.com)
  • Other tests have also indicated bronchodilating activity, while coumarin ( 1 ) was shown to be responsible for about 50 to 60% of this activity in relation to the total activity of the crude extract 5 . (scielo.br)
  • Advances in Structure and Activity Relationship of Coumarin Derivatives Edition by Penta, Santhosh and Publisher Academic Press. (vitalsource.com)
  • 2. The cDNA encodes a 49 kDa protein with coumarin 7-hydroxylase (COH) activity which cross-reacts with antisera to the mouse cytochrome P-450 isoenzyme responsible for COH activity and comigrates with a human liver microsomal protein. (portlandpress.com)
  • Recently, our laboratory has developed a novel series of isoprenylated coumarin derivatives that have exhibited anti-pancreatic cancer activity exclusively under nutrient-deprived conditions. (jcancer.org)
  • The biosynthetic pathway of coumarin is a part of phenylpropanoid metabolism. (frontiersin.org)
  • The biosynthesis of coumarin in plants is via hydroxylation, glycolysis, and cyclization of cinnamic acid. (wikipedia.org)
  • Nevertheless, the genes involved in the biosynthesis of core structure of coumarin in P. praeruptorum have not been identified yet. (frontiersin.org)
  • Biochemical characterization of the recombinant proteins revealed that Pp4CL1 utilized p -coumaric and ferulic acids as its two main substrates for coumarin biosynthesis in P. praeruptorum . (frontiersin.org)
  • Coumarin pyrazole hybrids have been synthesized from hydrazones, carbazones and thiocarbazones via Vilsmeier Haack formylation reaction. (wikipedia.org)
  • The synthesis of coumarin derivatives containing pyrazole, pyrazolone, thiazolidin-4-one, 5-carboxymethyl-4-thiazolidinone and 3-acetyl-1,3,4-oxadiazole ring is reported. (srce.hr)
  • Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to interfere with the interaction between vitamin K and coagulation factors II, VII, IX, and X. Vitamin K acts as a cofactor at these levels. (medscape.com)
  • The Pechmann condensation provides another route to coumarin and its derivatives, as does the Kostanecki acylation, which can also be used to produce chromones. (wikipedia.org)
  • 20-23 Coumarins have been synthesized by several routes including Pechmann, 24 Perkin, 25 Knoevenagel, 26 Refor-matsky 27 and the Wittig reaction. (scielo.org.za)
  • Coumarins and their derivatives have been prepared by a variety of methods, including Perkin, Wittig and Reformatsky reactions, Pechmann and Knoevenagel condensations, and Claisen rearrangement, among others. (eurekaselect.com)
  • Lacerda Jr, V. Coumarin-based hybrids as fluorescent probes for highly selective chemosensing and biological target imaging. (eurekaselect.com)
  • For example, coumarin extracted from southernwood ( Artemisia abrotanum L.) and essential oil of carnation flowers ( Dianthus caryophyllus L.) exerted a repellent effect against yellow fever mosquitoes ( Aedes aegypti L.) and ticks (nymphs of Ixodes ricinus L.) [ 18 ]. (hindawi.com)
  • Finally, the results indicate that some coumarins had selective inhibitory effects for EROD vs PROD and preliminary analyses suggested a possible structural basis for the observed differences. (nih.gov)
  • Essential oils and solvent extracts of plants containing coumarin have shown promising properties against mosquitoes. (hindawi.com)
  • Coumarins are used as laser dye-sensitized photoinitiators, for incorporation into polymer chains by co-polymerization, in the estimation of polymer solvent effects, for various structural characterizations, in the monitoring of the releasing properties of poly(methylmethacrylate) nanospheres and for polymeric fluorescent solar collectors. (sigmaaldrich.com)
  • This work studied the fluorescent and solvatochromic properties of coumarin and its derivatives aiming to contribute in the elucidation of the excited state behavior of the molecule in solvent mixtures. (scielo.br)
  • Hajinasiri, R. Preparation of a novel, efficient, and recyclable magnetic catalyst, γ-Fe 2 O 3 @HAp-Ag nanoparticles, and a solvent- and halogen-free protocol for the synthesis of coumarin derivatives. (eurekaselect.com)
  • Coumarin is found naturally in many plants, notably in high concentration in the tonka bean (Dipteryx odorata). (wikipedia.org)
  • Coumarin is found naturally also in many edible plants such as strawberries, black currants, apricots, and cherries. (wikipedia.org)
  • Coumarin and indanedione anticoagulant drugs are commonly used in the treatment of thromboembolic disorders. (annals.org)
  • O'REILLY RA, AGGELER PM. Surreptitious Ingestion of Coumarin Anticoagulant Drugs. (annals.org)
  • Centre Interfacultaire de Recherche en Pharmacochimie des substances naturelles et synthétiques, Laboratoire de Chimie Pharmaceutique, Université de Liège, Belgique. (nih.gov)
  • Although coumarin has been reported to exhibit anti-coagulant, anti-inflammation and cholesterol-lowering properties, the effect of coumarin on hepatic lipid metabolism remains unclear. (cambridge.org)
  • In the present study, we evaluated the ability of coumarin to protect against hepatic steatosis associated with a high-fat diet (HFD) and investigated potential mechanisms underlying this effect. (cambridge.org)
  • metabolize the coumarin into dicoumarol. (silt3.com)
  • One of these effects is cytotoxicity and apoptosis induction in cancerous cells by coumarins. (intechopen.com)
  • Metabolism of coumarin toward active metabolites, coumarin-induced cytotoxicity, and gene expression modulation were more pronounced in hepatocytes cultured in modified medium compared with hepatocytes cultured in standard medium. (tudelft.nl)