Coumarins: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.Umbelliferones: 7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.Mammea: A plant genus of the family CLUSIACEAE. Members contain xanthones and BENZOPHENONES. The common name of Mamey is also used with POUTERIA.Apiaceae: A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.4-Hydroxycoumarins: Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.Ferula: A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Heracleum: A plant genus of the family APIACEAE. Members contain COUMARINS.Psoralens: Linear furanocoumarins which are found in many PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA from which they were originally discovered. They can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate PYRIMIDINES, resulting in PHOTOSENSITIVITY DISORDERS.Aryl Hydrocarbon Hydroxylases: A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.Clausena: A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.Chromonar: A coronary vasodilator agent.Plant Bark: The outer layer of the woody parts of plants.Aminocoumarins: COUMARINS with an amino group, exemplified by NOVOBIOCIN.Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)Calophyllum: A plant genus of the family CLUSIACEAE. Members contain costatolide, calanolides and 4-phenylfuranocoumarins (FUROCOUMARINS).Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Angelica: A plant genus of the family Apiaceae.Acenocoumarol: A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)7-Alkoxycoumarin O-Dealkylase: A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolizes 7-alkoxycoumarin to 7-hydroxycoumarin. The enzyme is cytochrome P-450- dependent.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Anticoagulants: Agents that prevent clotting.Phenprocoumon: Coumarin derivative that acts as a long acting oral anticoagulant.Scopoletin: Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.Mikania: A plant genus of the family ASTERACEAE. Members contain scandenolide (a sesquiterpene lactone) and germacranolides.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Murraya: A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.Violaceae: A plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida.Rutaceae: A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.Pharmaceutic Aids: Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.EsculinMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Manufactured Materials: Substances and materials manufactured for use in various technologies and industries and for domestic use.Facility Regulation and Control: Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Micronucleus Tests: Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.Micronuclei, Chromosome-Defective: Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.Rats, Inbred F344Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).Rodenticides: Substances used to destroy or inhibit the action of rats, mice, or other rodents.Food Additives: Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.Flavoring Agents: Substances added to foods and medicine to improve the quality of taste.

Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. (1/1334)

The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. The more recently developed reversible MAO inhibitors with selectivity for either the MAO-A or MAO-B isoenzyme forms have not been studied extensively in animal models of epilepsy, so it is not known which type of MAO inhibitor is particularly effective in this respect. We compared the following drugs in the kindling model of epilepsy: 1) L-deprenyl (selegiline), i.e., an irreversible inhibitor of MAO-B, which, however, also inhibits MAO-A at higher doses, 2) the novel reversible MAO-B inhibitor LU 53439 (3,4-dimethyl-7-(2-isopropyl-1,3, 4-thiadiazol-5-yl)-methoxy-coumarin), which is much more selective for MAO-B than L-deprenyl, 3) the novel reversible and highly selective MAO-A inhibitor LU 43839 (esuprone; 7-hydroxy-3, 4-dimethylcoumarin ethanesulfonate), and 4) the irreversible nonselective MAO inhibitor tranylcypromine. Esuprone proved to be an effective anticonvulsant in the kindling model with a similar potency as L-deprenyl. In contrast to esuprone and L-deprenyl, the selective MAO-B inhibitor LU 53439 was not effective in the kindling model; this substantiates the previous notion that the anticonvulsant activity of L-deprenyl is not related to MAO-B inhibition, but to other effects of this drug, such as inhibition of MAO-A. Drugs inhibiting both MAO-A and MAO-B to a similar extent (tranylcypromine) or combinations of selective MAO-A and MAO-B inhibitors (esuprone plus LU 53439) had no advantage over MAO-A inhibition alone, but were less well tolerated. The data thus suggest that selective MAO-A inhibitors such as esuprone may be an interesting new approach for the treatment of epilepsy.  (+info)

7-ethoxycoumarin deethylation activity in perfused isolated rat brain. (2/1334)

7-ethoxycoumarin (7-EC) deethylation activity was measured in the perfused rat brain in situ. Infusion of 7-EC into a brain through an internal carotid artery resulted in the formation of 7-hydroxycoumarin (7-HC) and its conjugates in the effluent perfusate collected from the superior vena cava. The rate of formation of products was 200 nmol/h/g when 130 microM 7-EC was infused. This value was much higher (more than 100 times) than that determined from the brain microsomal activity ( approximately 1 nmol/h/g), indicating that the activity determined with microsomes was an underestimate. This value was comparable to the activity in the perfused liver (30-50%), suggesting that drug metabolizing enzymes can play important roles within the brain. Pretreatment of rats with P-450 inducers such as phenobarbital and beta-naphthoflavone increased the deethylation activity in the perfused brain, as in the perfused liver. We conclude that the perfused brain is suitable for evaluating drug metabolizing activities under physiological conditions.  (+info)

Effect of praeruptorin C on spontaneous [Ca2+]i transients in cultured myocardial cells of neonatal rats. (3/1334)

AIMS: To study the effects of praeruptorin C (Pra-C) on [Ca2+]i transients in cultured neonatal myocardiocytes. METHOD: Using Ca(2+)-sensitive fluorescent indicator, Fura 2-AM, spontaneous cytosolic Ca2+ transients were measured in cultured myocardial cells of neonatal rats. RESULTS: Pra-C 10, 30 mumol.L-1 caused a decrease in the peak of Ca2+ transients. Pra-C 30 mumol.L-1 and 10-30 mumol.L-1 inhibited partly the stimulatory effects of CaCl2 4.8 mmol.L-1 and Bay k 8644 100 nmol.L-1 on peak Ca2+ transients, respectively. Pra-C did not cause any marked change in the basal [Ca2+]i level between beats. Pra-C inhibited the reduced [Ca2+]i transients after inhibition of sarcoplasmic reticulum Ca2+ release in ryanodine pretreated cells. CONCLUSIONS: Pra-C inferred with the Ca2+ influx responsible for excitation-contraction coupling in myocardiocytes.  (+info)

Effects of praeruptorine C on the intracellular free calcium in normal and hypertrophied rat ventricular myocytes. (4/1334)

AIM: To study the intracellular free calcium ([Ca2+]i) in normal and hypertrophic left ventricular myocytes isolated from adult rat hearts and the effects of praeruptorine C (Pra-C) on them. METHODS: [Ca2+]i of single myocyte was measured with Fura 2-AM. RESULTS: The resting [Ca2+]i was 87 +/- 4 nmol.L-1 in normal left ventricular myocytes, 123 +/- 7 nmol.L-1 in hypertrophied myocytes. After exposure to KCl (20, 40, and 60 mmol.L-1), the [Ca2+]i were increased by 66%, 141%, and 268% in normal myocytes, and 77%, 185%, and 243% in hypertrophic myocytes, respectively. Pra-C (1, 10, and 100 mumol.L-1) concentration-dependently inhibited the [Ca2+]i elevation caused by KCl (35 mmol.L-1) or norepinephrine (20 mumol.L-1) in both normal and hypertrophied myocytes. All of the effects of Pra-C were similar to that of nifedipine. CONCLUSION: [Ca2+]i of hypertrophied myocytes was higher than that of normal ones and Pra-C decrease the [Ca2+]i elevation in left ventricular myocytes resulted from its calcium channel blockade.  (+info)

Rapid identification of Staphylococcus aureus by using fluorescent staphylocoagulase assays. (5/1334)

Two rapid (1-h) assays for the detection of Staphylococcus aureus staphylocoagulase were developed by using the fluorogenic thrombin substrates N-t-boc-Val-Pro-Arg-7-amido-4-methylcoumarin (VPA) and N-t-boc-beta-benzyl-Asp-Pro-Arg-7-amido-4-methylocoumarin (BB). The assays were compared to the tube coagulase test and latex agglutination (LA) (Sanofi Diagnostics Pasteur, Guildford, Surrey, United Kingdom) by using 406 clinical isolates of staphylococci, and they produced positive and negative predictive values of 99.2 and 99. 1% for LA, 98.9 and 92.7% for VPA, and 98.9 and 99.1% for BB. Fluorescent assays used colonies from solid media, thereby eliminating the need for broth cultures, and were performed in microtiter trays, thus making them suitable for large-scale screening.  (+info)

Caspase-dependent activation of calpain during drug-induced apoptosis. (6/1334)

We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced apoptosis of HL-60 cells (Wood, D. E., Thomas, A., Devi, L. A., Berman, Y., Beavis, R. C., Reed, J. C., and Newcomb, E. W. (1998) Oncogene 17, 1069-1078). Here we show the sequential activation of caspases and calpain during drug-induced apoptosis of HL-60 cells. Time course experiments using the topoisomerase I inhibitor 9-amino-20(S)-camptothecin revealed that cleavage of caspase-3 substrates poly(ADP-ribose) polymerase (PARP) and the retinoblastoma protein as well as DNA fragmentation occurred several hours before calpain activation and Bax cleavage. Pretreatment with the calpain inhibitor calpeptin blocked calpain activation and Bax cleavage but did not inhibit PARP cleavage, DNA fragmentation, or 9-amino-20(S)-camptothecin-induced morphological changes and cell death. Pretreatment with the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk) inhibited PARP cleavage, DNA fragmentation, calpain activation, and Bax cleavage and increased cell survival by 40%. Interestingly, Z-VAD-fmk-treated cells died in a caspase- and calpain-independent manner that appeared morphologically distinct from apoptosis. Our results suggest that excessive or uncontrolled calpain activity may play a role downstream of and distinct from caspases in the degradation phase of apoptosis.  (+info)

Activation of Xenopus eggs by proteases: possible involvement of a sperm protease in fertilization. (7/1334)

Egg activation in cross-fertilization between Xenopus eggs and Cynops sperm may be caused by a protease activity against Boc-Gly-Arg-Arg-MCA in the sperm acrosome. To determine the role of the sperm protease in fertilization, the protease was purified from Cynops sperm using several chromatographic techniques. We found that purified sperm protease readily hydrolyzes Boc-Gly-Arg-Arg-MCA and Z-Arg-Arg-MCA, that protease activity was inhibited by the trypsin inhibitors aprotinin and leupeptin, and that not only the purified protease, but also cathepsin B, induces activation in Xenopus eggs. We inseminated unfertilized Xenopus eggs with homologous sperm in the presence of various peptidyl MCA substrates or protease inhibitors and demonstrated that trypsin inhibitors or MCA substrates containing Arg-Arg-MCA reversibly inhibited fertilization of both fully jellied and denuded eggs. Sperm motility was not affected by the reagents. An extract obtained from Xenopus sperm showed hydrolytic activity against Boc-Gly-Arg-Arg-MCA, Z-Arg-Arg-MCA, and Arg-MCA. These results suggest that the tryptic protease in Xenopus sperm is involved in fertilization, most likely by participating in egg activation.  (+info)

Core RNA polymerase from E. coli induces a major change in the domain arrangement of the sigma 70 subunit. (8/1334)

Luminescence resonance energy transfer measurements were used to show that binding of E. coli core RNA polymerase induced major changes in interdomain distances in the sigma 70 subunit. The simplest model describing core-induced changes in sigma 70 involves a movement of the conserved region 1 by approximately 20 A and the conserved region 4.2 by approximately 15 A with respect to conserved region 2. The core-induced movement of region 1 (autoinhibition domain) and region 4.2 (DNA-binding domain) provides structural rationale for allosteric regulation of sigma 70 DNA binding properties by the core and suggests that this regulation may not only involve directly the autoinhibition domain of sigma 70 but also could involve a modulation of spacing between DNA-binding domains of sigma 70 induced by binding of core RNAP.  (+info)

Unscramble cumarin, Unscramble letters cumarin, Point value for cumarin, Word Decoder for cumarin, Word generator using the letters cumarin, Word Solver cumarin, Possible Scrabble words with cumarin, Anagram of cumarin
Two novel coumarin-based ligands, coumarin-6,7-dioxyacetic acid (1) (cdoaH(2))and 4-methylcoumarin-6,7-dioxyacetic acid (2) (4-MecdoaH(2)), were reacted with copper(II) and manganese(II) salts to give [Cu(cdoa)(H2O2)]center dot 1.5H(2)O (3), [Cu(4-Mecdoa)(H2O2)(2)] (4), [Mn(cdoa)(H2O2)(2)] (5) and [Mn(4-Mecdoa)(H2O2)2] center dot 0.5H(2)O (6). The metal complexes, 3-6, were characterised by elemental analysis, IR and UV-Vis spectroscopy, and magnetic susceptibility measurements and were assigned a polymeric structure. 1 and 2 react with Cu(II) in the presence of excess 1,10-phenanthroline (phen) giving [Cu(cdoa)(phen)(2)]center dot 8.8H(2)O (7) and [Cu(4-Mecdoa)(phen)(2)]center dot 13H(2)O (8), respectively. The X-ray crystal structures of 7 and 8 confirmed trigonal bipyramidal geometries, with the metals bonded to the four nitrogen atoms of the two chelating phen molecules and to a single carboxylate oxygen of the dicarboxylate ligand. The complexes were screened for their antimicrobial ...
0039] 3-Diethylamino-6-methylfluorane, 3-diethylamino-6-methyl-7-anilinofluorane, 3-diethylamino-6-methyl-7-(o,p-dimethylanilino)fluorane, 3-diethylamino-6-methyl-7-chlorofluoran, 3-diethylamino-6-methyl-7-(m-trifluoromethylanilino) fluorane, 3-diethylamino-6-methyl-7-(o-chloroanilino) fluorane, 3-diethylamino-6-methyl-7-(p-chloroanilino) fluorane, 3-diethylamino-6-methyl-7-(o-fluoroanilino) fluorane, 3-diethylamino-6-methyl-7-(m-methylanilino) fluorane, 3-diethylamino-6-methyl-7-n-octylanilino fluorane, 3-diethylamino-6-methyl-7-n-octylamino fluorane, 3-diethylamino-6-methyl-7-benzylamino fluorane, 3-diethylamino-6-methyl-7-dibenzylamino fluorane; 3-diethylamino-6-chloro-7-methyl fluorane, 3-diethylamino-6-chloro-7-anilino fluorane, 3-diethylamino-6-chloro-7-p-methylanilino fluorane, 3-diethylamino-6-ethoxyethyl-7-anilino fluorane, 3-diethylamino-7-methyl fluorane, 3-diethylamino-7-chloro fluorane, 3-diethylamino-7-(m-trifluoromethylanilino) fluorane, 3-diethylamino-7-(o-chloroanilino) ...
Coumarin is often found in tobacco products and artificial vanilla substitutes, though it has been banned as a food additive in numerous countries since the mid-20th century because it is moderately toxic to the liver and kidneys, with an LD50 of 275 mg/kg - low compared to related compounds. Although only somewhat dangerous to humans, coumarin is a potent rodenticide: rats and other rodents largely metabolize it to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans largely metabolize it to 7-hydroxycoumarin, a compound of lower toxicity. Coumarin was banned as a food additive in the United States in 1978. OSHA considers this compound to be only a lung-specific carcinogen, and "not classifiable as to its carcinogenicity to humans" [2]. Coumarin was banned as an adulterant in cigarettes by tobacco companies in 1997, but due to the lack of reporting requirements to the US Department of Health and Human Services it was still being used as a flavoring ...
adenosine triphosphate (7-(diethylamino)coumarin-4-yl)methyl ester: a caged form of ATP for light controlled transcription reactions in vitro; structure in first source
Coumarins are a structurally diverse group of natural substances derives from plants that display a host of bioactivities. In this paper, we will introduce the reader to coumarins and their applications as medicinal substances. The great diversity in courmarin structure will be discussed along with their extensive use as pharmaceutical agents. Coumarins display a wide range of antimicrobial activity and applications of coumarins as antifungal and antiviral agents will be addressed. Other properties of coumarins such as their role in neuroprotection, anticancer, and as antioxidants will also be reviewed ...
Methyl coumarin-3-carboxylate | C11H8O4 | CID 30553 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Coumarin-4-acetic acid 7-beta-D-galactopyranoside/AFI127615741 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
6,7-Bis(carboxymethoxy)coumarin-4-yl)methyl-adenosine-3,5-cyclic monophosphate(bcmcm-caged camp)/ACM339291519 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Effect of synthetic coumarin derivatives on HT1080 fibrosarcoma cell invasion. Chemoinvasion and chemotaxis were evaluated in Transwell cell culture inserts coa
Following absorption, coumarin binds to albumin and other plasma proteins. After administration of the optimal dose, a large proportion of the interstitial plasma proteins reach the maximum carrying amount of coumarin attached to these proteins. This complex-albumin coumarin is phagocytosed by macrophages and monocytes, resulting in amino acids and peptides which are simultaneously released into the extracellular proteases. The protein fragments of the addition product of these processes are removed from the gap through the veins, in contrast to the proteins of high molecular weight which depend on the lymphatic system to be removed. Therefore, these protein fragments of lower molecular weight, high diffusion coefficient and its consequent ability to penetrate small pores play a role in the mechanism of action of Venalot Depot ®. After the removal of proteins accumulated fluid drainage is performed accordingly and tissue restoration. The immediate effect of coumarin rheological and troxerutin ...
ent policies and plans are also discussed as well as manufacturing processes and cost structures. Coumarin market report also states import/export, supply and figures as well as cost, price, revenue and gross margin by regions (United States, EU, China and Japan), and other regions can be added.. For Pre-Order Enquiry on Coumarin market, [email protected] http://www.360marketupdates.com/enquiry/pre-order-enquiry/10480486 Then, Coumarin market report focuses on major leading industry players with information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials, and downstream consumers analysis is also carried out. Whats more, the Coumarin industry development trends and marketing channels are analysed.. For each player, product details, capacity, price, cost, gross and revenue numbers are given. Their contact information is provided for better understanding.. Finally, the feasibility of new investment ...
Coumarin China Supplier of Coumarin (CAS: 91-64-5) picture from Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. view photo of Coumarin, Food Additives, Chemical.Contact China Suppliers for More Products and Price.
Looking for Coumarin? Find out information about Coumarin. C9H6O2 The anhydride of o -coumaric acid; a toxic, white, crystalline lactone found in many plants and made synthetically; used in making perfume and soap.... Explanation of Coumarin
The only frequent adverse reaction during therapy with oral anticoagulants is bleeding due to depression of vitamin K-dependent hepatic clotting proteins. Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign events such as gastrointestinal dysfunction, hypersensitivity dermatitides, drug fever, and alopecia. Only one serious complication remains poorly understood: coumarin necrosis of skin and subcutaneous tissue. Widely reported in Europe (1-10) it has received little attention in English-speaking countries (11-14) and is still being misinterpreted as a hemorrhagic effect.. Although clinical use of bishydroxycoumarin began in 1940, coumarin necrosis was not recognized until ...
Kabeya, L. M., Marchi, A. A. de, Kanashiro, A., Lopes, N. P., Silva, C. H. T. de P. da, Pupo, M. T., & Lucisano-Valim, Y. M. (2007). Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: synthesis and structure-activity relationships. Bioorganic & Medicinal Chemistry, 15( 3), 1516-1524. doi:10.1016/j.bmc.2006.10. ...
The eleven recombinant human cytochromes P450 (1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 3A5, and 4A11 SUPERSOMES), 3-cyano-7-ethyoxycoumarin (CEC), 7-methoxy-4-trifluoromethylcoumarin (MFC), 7-benzyloxy-trifluoromethylcoumarin (BFC), and 3-[2-(N,N diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin (AMMC) were purchased from BD Biosciences (Woburn, MA). The 7-ethoxy-4-trifluoromethylcoumarin (EFC) was purchased from Molecular Probes (Eugene, OR). Glutathione, PCP, 1-(1-(phenyl-d5)-cyclohexyl)piperidine (d5-PCP), NADPH, and ferrous chloride were all purchased from Sigma (St. Louis, MO). Thirty-percent hydrogen peroxide was a JT Baker solvent (Phillipsburg, NJ). Authentic standards for PCP metabolites M1-M3 and M5 (Fig. 1) were obtained from within the Pfizer chemical archives (Pfizer Inc., Groton, CT). The PCP ketone derivatives, 4-phenyl-4-piperidinecyclohexanone and 1-(1-phenylcyclohexyl)piperidin-4-one, were also obtained from the Pfizer chemical archives.. Fenton Reactions. A typical ...
Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.
2: 42%, VKORC1*3: 38%, and VKORC1*4: 20%), which were in complete linkage disequilibrium. These haplotypes were further subdivided by additional polymorphisms. Haplotype VKORC1*2 includes a SNP in the promoter region (c.-1639G>A, dbSNP:rs17878363 that was identified as a marker for low dose warfarin requirement.. In a cohort of 50 consecutive patients without mutations in the VKORC1 coding region who presented with phenotypes of either increased coumarin sensitivity or partial coumarin resistance we found a strong association of VKORC1 haplotypes and the observed phenotype. 93% of patients with increased coumarin sensitivity but none of patients with partial coumarin resistance were found to be homozygous for VKORC1*2. Vice versa, non VKORC1*2 haplotypes were found homozygous in 86% of patients with partial coumarin resistance but in none of patients with increased coumarin sensitivity.. The VKORC1*2 haplotype also explains inter-ethnic differences in coumarin requirement. Haplotype analysis ...
Abstract: The development of antioxidants as useful drugs for the treatment of neurodegenerative diseases such as Alzheimers is extremely challenging in medicinal chemistry. Coumarins have attracted great attention as possible therapeutic tools against oxygen radicals in human degenerative diseases. In order to establish the possible structure-antioxidant activity relationship, a series of twenty four 4-methylcoumarin derivatives were examined by employing reducing power measurements, and comparison with bond dissociation enthalpy and ionization potential calculations. Based on the reducing potency of 4-methylcoumarin derivatives with respect to trolox, these compounds were classified into five groups as "most active", "more active", "moderately active", "less active" and "inactive" derivatives. The presence of hydroxyl groups is an essential requirement for the activity, and substitution of hydroxyl groups by methoxy groups leads to non-active derivatives. The results revealed that dihydroxyl ...
We report a new method, Interaction-Dependent PRobe Incorporation Mediated by Enzymes, or ID-PRIME, for imaging protein-protein interactions (PPIs) inside living cells. ID-PRIME utilizes a mutant of Escherichia coli lipoic acid ligase, LplA[superscript W37V], which can catalyze the covalent ligation of a coumarin fluorophore onto a peptide recognition sequence called LAP1. The affinity between the ligase and LAP1 is tuned such that, when each is fused to a protein partner of interest, LplA[superscript W37V] labels LAP1 with coumarin only when the protein partners to which they are fused bring them together. Coumarin labeling in the absence of such interaction is low or undetectable. Characterization of ID-PRIME in living mammalian cells shows that multiple protein-protein interactions can be imaged (FRB-FKBP, Fos-Jun, and neuroligin-PSD-95), with as little as 10 min of coumarin treatment. The signal intensity and detection sensitivity are similar to those of the widely used fluorescent protein ...
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Development of efficient unimolecular visible light photoinitiators (PIs) with photobleaching capabilities, which is essential for various biomedical applications and photopolymerization of thick materials, remains an emerging challenge. Based on the photochemistry of heteroaromatic compounds, unimolecular visible
coumarin 7-hydroxylase: CYP2A5 hyrdoxylates DHEA in at least three positions (7alpha, 7beta, and 2alpha); some enzyme preparations hydroxylate at position 3 & position 7; if cytochrome P-450coh is mutated at position 209, its substrate specificity is changed from coumarin hydroxylation (coh) to steroid hydroxylation
7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. Buy 7ACC1 (DEAC; Coumarin D 1421; D 1421) from AbMole BioScience.
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray New Talent: Europe
The first region 4 open reading frame 3 protein FLNA (E4-ORF3; UniProt Identification "type":"entrez-protein" attrs :"text":"P04489″ term_id :"119084″ term_text :"P04489″P04489) may be the most extremely conserved of most adenovirus-encoded gene items on the amino acidity level. supplementary/tertiary framework and the capability to type heterogeneous higher-order multimers in option. Importantly a non-functional E4-ORF3 mutant proteins L103A forms a well balanced dimer with WT supplementary structure content. As the L103A mutant is certainly Coumarin 30 not capable of PML reorganization this result shows that higher-order multimerization of E4-ORF3 could be necessary for the experience of the proteins. To get this hypothesis we demonstrate the fact that E4-ORF3 L103A mutant proteins works as a dominant-negative effector when coexpressed using the WT E4-ORF3 in mammalian cells. It prevents WT E4-ORF3-mediated PML monitor development presumably by binding towards the WT proteins and ...
Coumarin 343;55804-65-4;1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylicacid, 2,3,6,7-tetrahydro-11-oxo-;ABP001118.Active Biopharma Corp
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
Sigma-Aldrich offers Sigma-C0855, Z-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrobromide for your research needs. Find product specific information including CAS, MSDS, protocols and references.
TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE 63909-29-5 NMR spectrum, TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE H-NMR spectral analysis, TRANS-3-BENZYLOXY-4-METHOXY-β-NITROSTYRENE C-NMR spectral analysis ect.
BioAssay record AID 513048 submitted by ChEMBL: Inhibition of human caspase-3-mediated apoptosis assessed as Ac-DEVD-7-amino-4-methylcoumarin cleavage product at 100 uM by fluorescence assay.
7-Amino-4-methylcoumarin (AMC) can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates. The fluorescence spectra of AMC is not subject to variability due to pH-dependent protonation/deprotonation when assayed near or above physiologica
Gentaur molecular products has all kinds of products like :search , Biovis \ 7-Amino-4-methylcoumarin; Appearance Yellow to yellow green solid \ 1844-25 for more molecular products just contact us
Lehnert, S, "Toxicity to tumor cells of combined treatments with diethylamino- reserpine and radiation. Abstr." (1982). Subject Strain Bibliography 1982. 3894 ...
Looking for Marevan? Find out information about Marevan. anticoagulant anticoagulant , any of several substances that inhibit blood clot formation . Some anticoagulants, such as the coumarin derivatives... Explanation of Marevan
Gilvocarcin V (GV) and ravidomycin (RMV) exhibit excellent antitumor activities in the presence of near-UV light at low concentration maintaining a low in vivo cytotoxicity. Although, the exact molecular mechanism for in vivo actions of these antibiotics has yet to be determined, a [2+2] cycloaddition reaction of the vinyl side chain with DNA thymidine residues in addition to the inhibition of topoisomerase II and DNAhistone H3 cross-linking are reported for the GVs mechanism of action. Such activities have made these molecules interesting candidates for the biosynthetic investigation to generate analogues with improved activity/solubility. Previous biosynthetic studies have suggested that the GV biosynthetic pathway involves a number of synchronously occurring transformations leading to the oxidative C-C bond cleavage and other intriguing biosynthetic reactions, such as the vinyl side chain formation, methylations, Cglycosylation and dehydrogenation. Although gene inactivation results identified many
A new coumarin identified as 5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one (isoobtusitin) was isolated… Expand ...
November 6, 2018, admin Angiotensin Receptors, Many viral proteins undergo proteolytic processing events that are necessary for virus infection and virion assembly. WNV NS3 was suggested to process mainly NS2ANS2BNS3NS4A at combined basic proteins occupying the P1 and P2 positions. Certainly, purified NS3 was discovered to cleave the anthrax toxinprotective antigen PA83 [3], whereas the furin/PC-like pentapeptide fluorogenic substrate Pyr-RTKR-MCA [PyroGlu-Arg-Thr-Lys-Arg-(4-methylcoumarin-7-amide)] […]. 13463-28-0 IC50, Rabbit Polyclonal to JAB1. ...
Seven new coumarin analogues (1, 2, and 4-8), together with ten known analogues (3, 9-17), were isolated from the air-dried pericarp of Citrus grandis. The ...
Abbe, Ernst, Barnard, Christiaan N, Behring, Emil von, Bourgeois, Louyse, Bragg, William Henry & William Lawrence, Chain, Ernst Boris, Coolidge, William David, Crick, Francis Harry Compton, Curie, Marie, Davy, Humphry, etc…
The synthesis of functionalized 2-oxo-2H-coumarin derivatives has been studied by a one-pot reaction of o-hydroxybenzaldehyde, ethyl 2-bromoacetate and triphenylphosphine in the presence of catalytic amount of triethyl amine in EtOAc, water or under solvent free conditions. We have found the best results obtained under solvent free condition.
Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163- ...
Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this...
12822997] The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins. (J Am Chem Soc. , 2003 ...
You are viewing an interactive 3D depiction of the molecule methyl {7-hydroxy-2-[(6r)-6-hydroxyheptyl]-4-oxo-4h-chromen-5-yl}acetate (C19H25O6+) from the PQR.
(methylsulfanyl)(4-oxo-4H-chromen-2-yl)methyl acetate - chemical structural formula, chemical names, chemical properties, synthesis references
You are viewing an interactive 3D depiction of the molecule o-[(4-methyl-2-oxo-2h-chromen-7-yl)carbamoyl]-l-serine (C14H15N2O6+) from the PQR.
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Combining aspirin with coumarin after a heart attack appears to work better than either medicine taken alone in preventing future cardiac troubles, according to two studies published last week.In
Z-Leu-Arg-AMC Z-LR-AMC | Z-Leu-Arg-MCA 3210-v 5 mg | 65.00 EURBenzyloxycarbonyl- L-leucyl- L-arginine 4-methylcoumaryl-7-amide (M.W.
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
Looking for online definition of Coumarins in the Medical Dictionary? Coumarins explanation free. What is Coumarins? Meaning of Coumarins medical term. What does Coumarins mean?
Interactions of several 7-aminocoumarins with human serum albumin (HSA) were studied by using fluorescence spectroscopic technique and modeling studies. There is a large change in fluorescence spectral parameters like intensity, emission maxima and anisotropy for all aminocoumarins. There were two binding sites for cou-1, 311 and a single binding site for other coumarins. The binding constant(s) are large for all coumarins reflective of a strong binding. These spectral studies show that structural variants at the third, fourth and seventh position affects binding. The probable location of these coumarins in domain Ii has been predicted based on modeling. The effect of structural modification on the efficiency of binding was obtained for various other coumarins, using modeling.. ...
Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K-dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy ...
Background and objectives: Interaction of compounds with ct-DNA can affect the replication, protein synthesis and cell division. Different species of the genus Ferula (Apiaceae) have shown various biomedical applications for many centuries. Biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins. Consequently, binding studies of sesquiterpen coumarin with ct-DNA are useful for the understanding of the reaction mechanism and providing guidance for the application and design of new and more efficient drugs targeted to DNA. Interaction of galbanic acid (GA) with ct-DNA, was evaluated by cyclic voltammetry (CV), diggerential pulse voltammetry (DPV), enhancement fluorescence, UV-VIS and FT-IR spectroscopy. Methods: The oleo gum-resin of Ferula assa-foetida was collected and dried in spring. Hexane extract of gum was prepared and defatted. Several coumarins were purified
L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE 115918-60-0 safety info, L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE chemical safety search, Chemical L-SERINE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE safety technical specifications ect.
Coumarin is acclimated in assertive perfumes and bolt conditioners. Coumarin has been acclimated as an balm enhancer in aqueduct tobaccos and assertive alcoholic drinks, although in accepted it is banned as a flavorant aliment additive, due to apropos apropos its hepatotoxicity in beastly models. The chat Tonka for tonka beans is taken from the Galibi…
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity ...
0049] Nucleotides for nucleic acid sequencing according to the invention preferably include a detectable label that is directly or indirectly detectable. Preferred labels include optically-detectable labels, such as fluorescent labels. Examples of fluorescent labels include, but are not limited to, Atto dyes, 4-acetamido-4-isothiocyanatostilbene-2,2disulfonic acid; acridine and derivatives: acridine, acridine isothiocyanate; 5-(2-aminoethyl)aminonaphthalene-1-sulfonic acid (EDANS); 4-amino-N-[3-vinylsulfonyl)phenyl]naphthalimide-3,5 disulfonate; N-(4-anilino-1-naphthyl)maleimide; anthranilamide; BODIPY; Brilliant Yellow; coumarin and derivatives; coumarin, 7-amino-4-methylcoumarin (AMC, Coumarin 120), 7-amino-4-trifluoromethylcouluarin (Coumaran 151); cyanine dyes; cyanosine; 4,6-diaminidino-2-phenylindole (DAPI); 55-dibromopyrogallol-sulfonaphthalein (Bromopyrogallol Red); 7-diethylamino-3-(4-isothiocyanatophenyl)-4-methylcoumarin; diethylenetriamine pentaacetate; ...
TY - CONF. T1 - Novel coumarins with improved solubility as FXIIa inhibitors. AU - Bouckaert, Charlotte. AU - Vancraeynest, Christelle. AU - Dolušić, Eduard. AU - Frédérick, Raphaël. AU - Pochet, Lionel. PY - 2013. Y1 - 2013. N2 - Background: Thrombotic diseases remain a major cause of death in industrialised countries. Anticoagulants have proven their efficacy to address these disorders. However severe bleeding complications are still reported even with the use of recently marketed drugs. Novel and safe antithrombotics are thus required.In this perspective, coagulation factor XIIa (FXIIa), a serine protease implicated in the contact phase of coagulation cascade, recently emerged as a promising target in the development of such agents. Indeed, it was demonstrated that FXII deficiency or inhibition protects against thrombosis without causing spontaneous bleeding in mice.Aim: Based on these considerations, the goal of our project is to develop novel selective FXIIa inhibitors to detail the ...
Read "Fluorescence studies in environmentally benign solvents: solvation dynamics of Coumarin 102 in [BMIM][BF4], Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
A Student Researched Lab Analysis about cost effective Pd-catalyzed Coumarin Synthesis. Reaction substrates and conditions could be used in large scale.
TY - JOUR. T1 - Insight into the mode of action of coumarins as thrombin inhibitors. AU - Frédérick, Raphaël. AU - Charlier, Caroline. AU - De Ruyck, Jerome. AU - Dieu, Marc. AU - Robert, Séverine. AU - Masereel, Bernard. AU - Pochet, Lionel. PY - 2004. Y1 - 2004. M3 - Literature review. VL - 18. SP - 595. JO - Fundamental and Clinical Pharmacology. JF - Fundamental and Clinical Pharmacology. SN - 0767-3981. ER - ...
While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation has prompted the development of alternative nanomaterials-based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin-4-yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)
Coumarin (; 2H-chromen-2-one) is a fragrant organic chemical compound in the benzopyrone chemical class, although it may also be seen as a subclass of lactones. It is a natural substance found in many plants, and a colorless crystalline substance in its standard state. The name comes from a French term for the tonka bean, coumarou, one of the sources from which coumarin was first isolated as a natural product in 1820 ...
2H-Chromen-2-ones, commonly known as coumarins, are naturally occurring oxygen heterocyclic compounds which have a distinct and important place in natural and synthetic organic chemistry, as they have been found to exhibit varying degrees of biological activities, namely, antibacterial, antiviral, anticancer and anti HIV [1-3]. These have been reported to display activity against several types of animal tumors [4], prostate cancer and metastatic renal cell carcinoma [5] and have also been used as additives in food, cosmetics [6], optical brighteners [7], dispersed fluorescent and laser dyes [8].. Due to the importance of the 2H-chromen-2-ones, continuous efforts have been made to simplify the procedures for the synthesis of these compounds, which include use of Pechmann and Duisberg [9], Perkin and Henry [10], Knoevenagal [11], Reformatsky [12] and Wittig [13] reactions. Among these, the Pechmann condensation is considered to be one of the most important, as it requires simple starting ...
Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo.
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Four new coumarins (2,3-dihydroxyphellopterin, E-5-methoxytrichoclin acetate, Z-5-methoxytrichoclin acetate, and E-5-methoxytrichoclin) and three known coumarins (byakangelicol, byakangelicin, and Z-5-methoxytrichoclin) were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The chemical structures were elucidated on the basis of their spectroscopic data. The inhibitory activities of nitric oxide (NO) production in ...
Abbasi, S. and Khaledi, M. and Gholipour, A. and Heydari, R. (2017) Assessment of the Prevalence of Staphylococcus Areus in Nose of the Surgical Staff of Hajar and kashanis Hospital in 2015. Journal of Shahrekord Uuniversity of Medical Sciences, 19. Abdizadeh, T. and Kalani, M.R. and Abnous, K. and Tayarani-Najaran, Z. and Khashyarmanesh, B.Z. and Abdizadeh, R. and Ghodsi, R. and Hadizadeh, F. (2017) Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents. European Journal of Medicinal Chemistry, 132. pp. 42-62. Abedi, A. and Mortazavi, M. and Mirmosayyeb, O. and Taheri, Sh. and Afsharmoghadam, N. and Asadi-Samani, M. and Sajadieh, Sh. and Baradaran, A. (2017) Decoy Cell Viruria in Kidney Transplant Patients. Does it correlate with Renal Function? WORLD FAMILY MEDICINE, 15 (5). pp. 20-25. Abedi, E. and Khezri, S. and Abtahi, S.M. (2017) Evaluation of the chlorpromazine effect on experimental autoimmune ...
Structure and Function of XenA xycoumarin 4 and 3-(2,3-dihydroxyphenyl)-propionic acid 5 (The enzymes producing Approximately 15 × 106 tons of coal tar are and converting these two compounds are not produced worldwide every year and are the source known. Quinoline degrading P. putida strains do for condensed aromatics and N-heteroaromatics like not grow with coumarin as a sole source of carbon and energy. However, when bacteria that were have developed strategies to metabolize naturally grown with quinoline are incubated with coumarin occurring aromatic compounds and xenobiotics and 6, 3-(2-hydroxyphenyl)-propionic acid 7 accumu- as they are able to biomineralize potentially toxic latesCharacteristic reactions of coumarins are compounds, they can be exploited in the bioreme- additions to the C-3/C-4 double bond and the diation of polluted soils and Quinoline is a nucleophilic opening of the lactone group.Addi- ubiquitous, soluble, heteroaromatic pollutant with tion of a hydride and a proton to ...
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2 ...
Khellol Glucoside, Psoralen, Cantharides Beetles The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. They are biosynthesized partly through the phenylpropanoid pathway and the mevalonate pathway,
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push-pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin ...
The interaction of Eu(III) ion with 7-carboxymethoxy-4-methylcoumarin (CMMC) has been investigated using the potentiometric method in the ethanol-water mixture solvent (0.15 volume fraction). The formation of the different binary, ternary complexes is confirmed by the corresponding pH-potentiometric curves. SUPERQUAD computer program has been used for the refinement of all the calculated constants in our present study. Electroanalytical techniques have been used to confirm the formation of different binary and ternary complexes under investigation. The binding constant of the ternary complex Eu(III)-CMMC-DNA calculated by cyclic voltammetry (CV) and differential pulse (DP) was found to be 1.8 and 2.5x 105 M-1 in Tris-HCl, respectively. The changes in the current intensity have been used for the quantitative determination of DNA over a linear concentration range with LOD of 1.0-1.3 µg/ ml in 0.1 M Tris-HCl buffer.. ...
The goals of therapy are 1) stabilization with supportive treatment of the patient, 2) prevention of thrombus expansion and the formation of additional clots, and 3) reduction in size of the existing clots and restoration of perfusion. Stabilization may involve oxygen therapy, fluid therapy, and analgesia. Management should be provided based on the individual patients needs.. Anticoagulant therapy in veterinary patients consists primarily of various types of heparin. Coumarin derivatives can also be used, but will not be discussed here. Heparins enhance the inhibitory activity of AT by binding to AT, which then inactivates thrombin and factor Xa. Short molecules of heparin are better at catalyzing AT to inhibit factor Xa than to inhibit thrombin. Heparins can also cause the release of TFPI from the endothelial surface. Sodium heparin is an unfractionated heparin, and contains heparin molecules of varying sizes. It is widely available and inexpensive. Unfractionated heparin has the highest ...
Novobiocin is an antibiotic which binds to a 24 kDa fragment from the B subunit of DNA gyrase. Naturally occurring resistance arises from mutation of Arg-136 which hydrogen bonds to the coumarin ring of novobiocin. We have applied calorimetry to characterize the binding of novobiocin to wild-type and R136H mutant 24 kDa fragments. Upon mutation, the Kd increases from 32 to 1200 nM at 300 K. The enthalpy of binding is more favorable for the mutant (DeltaH degrees shifts from -12.1 to -17.5 kcal/mol), and the entropy of binding is much less favorable (TDeltaS degrees changes from -1.8 to -9.4 kcal/mol). Both of these changes are in the direction opposite to that expected if the loss of the Arg residue reduces hydrogen bonding. The change in heat capacity at constant pressure upon binding (DeltaCp) shifts from -295 to -454 cal mol-1 K-1. We also report the crystal structure, at 2.3 A resolution, of a complex between the R136H 24 kDa fragment and novobiocin. Although the change in DeltaCp often ...
Opopanax chironium is a rich source of furano- and dihydrofuranocoumarins, whose accumulation in all plant parts and especially the roots is presumably responsible for the poisonous properties of the species. The presence of two distinct chemotypes was evidenced, with the one from Sicily affording the new dihydrofuranocoumarins 5d and 5e, while extracts from the Sardinian chemotype showed powerful apoptotic activity, which was traced to the prenylated furanocoumarins heraclenin (2a) and imperatorin (2b). Despite a close structural similarity, compounds 2a and 2b induced apoptosis in Jurkat leukemia cells in mechanistically different ways.
Structure, properties, spectra, suppliers and links for: (2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-phenyl-3-{[(2,6-|sup>3|.
Structure, properties, spectra, suppliers and links for: (1β,2α,5β,7β,8α,10α,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoy.
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... -CROMIC GUT- Blunt Suture 2-0 2-0, NCT-2 BLUNT NEEDLE for safe practice of loading and passing 12 per box
INDOFINE Chemical Company supplies FRAXIN with HPLC for pharmaceutical, agricultural and life science industries. We provide CAS 524-30-1 MSDS, Certificate of analysis references.
InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1 ...
Biological Process: 9-cis-retinoic acid biosynthetic process; aging; amine metabolic process; camera-type eye development; cell proliferation; coumarin metabolic process; dibenzo-p-dioxin catabolic process; drug metabolic process; epoxygenase P450 pathway; ethylene metabolic process; flavonoid metabolic process; gut development; hydrogen peroxide biosynthetic process; insecticide metabolic process; maternal process involved in parturition; porphyrin metabolic process; regulation of lipid metabolic process; response to antibiotic; response to arsenic; response to drug; response to food; response to herbicide; response to hyperoxia; response to hypoxia; response to iron(III) ion; response to lipopolysaccharide; response to nematode; response to virus; response to vitamin A; response to wounding; steroid metabolic process; vitamin D metabolic process ...
Celery is a strongly alkaline food that helps to counteract acidosis, purify the bloodstream, aid in digestion, prevent migraines, relax the nerves, reduce blood pressure, and clear up skin problems. Celery contains compounds called coumarins which are known to enhance the activity of certain white blood cells and support the vascular system. Celerys rich organic sodium content has the ability to dislodge calcium deposits from the joints and holds them in solution until they can be eliminated safely from the kidneys. Celery is a well known natural diuretic and has ample ability to flush toxins out of the body. Celery also has significant anti-inflammatory properties making it an essential food for those who suffer from auto-immune illnesses. It also contains significant amounts of calcium and silicon which can aid in the repair of damaged ligaments and bones. Celery is rich in vitamin A, magnesium, and iron which all help to nourish the blood and aid those suffering from rheumatism, high blood ...
Hello basenoters, I just got my first small batch of aromachemichals and, to my surprise, some of them are in powder: Musk ketone, coumarin and indole. I have no clue on how to use them. Should I dilute them in ethanol or what? Sorry for the silly question, but I really need advice. Also, some are listed as toxic or even poisonous (indole carries a scary skull on the label). As I am doing some olfactory exercises on every new material I get, and I only had naturals so far. Should I
As we know that most of the optical brughteneing agent are ionic in their nature so why do some optical brightener form suspension in water? some important optical brightener agents are: 1.Stilbene 2.Diazole 3. Triazole 4. Coumarins 5.Imidazoles Also submitted: Do optical brighteners contain chromophores ...
Warferin or Coumarin Naturally optain from Melilotus alba. --- (Pirmohamad, Munir. "Warfarin: Almost 60 Years Old And Still Causing Problems". Br J Clinical Pharmacol 62.5 (2006): 509-511. Web. 24 Jan. 2017 ...
Canuto, Kirley M, Lima, Mary Anne S and Silveira, Edilberto R Amburosides C-H and 6-O-protocatechuoyl coumarin from Amburana cearensis. J. Braz. Chem. Soc., 2010, vol.21, no.9, p.1746-1753. ISSN 0103- ...
Learn more about 3-ethoxy-2-ethoxycarbonyl-3-oxoprop-1-enyl-amino-acetic-acid. We enable science by offering product choice, services, process excellence and our people make it happen.
...A huge variation exists in the amounts of coumarin in bark samples o...Friederike Woehrlin and colleagues note that cinnamon is the second mo...The scientists analyzed 91 cinnamon samples purchased from stores in G...Health officials say...,Levels,of,coumarin,in,cassia,cinnamon,vary,greatly,even,in,bark,from,the,same,tree,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in the treatment of lymphedema and different types of cancer. Several previous pharmacokinetic studies of coumarin have been performed in humans, which revealed extensive first-pass metabolism of the compound. 7-Hydroxycoumarin (7-HC) and its glucuronide (7-HC-G) are the main metabolites formed in humans, and via this route, 80 to 90% of the absorbed coumarin is excreted into urine, mainly as 7-HC-G. Active transport processes play a role in the urinary excretion of 7-HC-G; however, until now, the transporters involved remained to be elucidated. In this study, we investigated whether the efflux transporters multidrug resistance-associated proteins (MRP)1-4, breast cancer resistance protein, or P-glycoprotein play a role in 7-HC and 7-HC-G transport. For this purpose, we measured uptake of the metabolites into membrane vesicles overexpressing ...
The 5-methyl-2-pyrrolylcarbonyl moiety of the aminocoumarin antibiotics clorobiocin and coumermycin A1 is the key pharmacophore for targeting the ATP-binding site of GyrB for inhibition of the bacterial type-II topoisomerase DNA gyrase. During the late stage of clorobiocin and coumermycin A1 biosynthesis, the pyrrolyl-2-carboxyl group is transferred from the peptidyl carrier proteins Clo/CouN1 to the 3-hydroxyl of the 4-methoxy-L-noviosyl scaffold by the action of the acyltransferases Clo/CouN7. CouN1 and CouN7 have now been heterologously expressed and purified from Escherichia coli. The apo form of CouN1 is converted to the acyl-holo form by loading with pyrrolyl-2-carboxyl-S-pantetheinyl moieties from synthetic pyrrolyl- and 5-methylpyrrolyl-CoAs by the action of the phosphopantetheinyl transferase Sfp. CouN7 acts as an acyltransferase, moving the pyrrole acyl moieties from CouN1 to the noviose sugar of descarbamoylnovobiocin. When the 5-methylpyrrolyl-2-carboxyl-thioester of CouN1 is the
Using electrospray tandem mass spectrometry (ESI MS n), the flavonoids obtained from leaves in Acanthopanax Senticosus Harms were analyzed. The typical colorimetric method and the ultroviolet spectrophotometry were also utilized for the determination of the content of total flavonoids. The analytical results showed that there was quercetin as well as its derivatives in leaves of acanthopanax senticosus harms and their content was as high as 37.25%.
The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treatment of postmenopausal women with breast cancer. A series of tricyclic coumarin sulfamates were synthesized, and their inhibitory properties were examined in vitro and in vivo. In a placental microsomal assay system, 667 COUMATE emerged as the most potent inhibitor with an IC50 of 8 nM. Administration of a single dose (10 mg/kg, p.o.) of 667 COUMATE inhibited rat liver estrone sulfatase activity by 93%. 667 COUMATE was devoid of estrogenicity, as indicated by its failure to stimulate the growth of uteri in ovariectomized rats. In vivo, estrone sulfate-stimulated growth of uteri in ovariectomized rats was inhibited by 667 COUMATE. Using the nitrosomethylurea-induced mammary tumor model, we found that 667 COUMATE caused regression of estrone sulfate-stimulated tumor growth in a dose-dependent manner. The identification of 667 COUMATE as a potent steroid sulfatase inhibitor will enable the
A "huge" variation exists in the amounts of coumarin in bark samples of cassia cinnamon from trees growing in Indonesia, scientists are reporting in a new study. That natural ingredient in the spice may carry a theoretical risk of causing liver damage in a small number of sensitive people who consume large amounts of cinnamon. The report appears in ACS bi-weekly Journal of Agricultural and Food Chemistry.. Friederike Woehrlin and colleagues note that cinnamon is the second most popular spice, next to black pepper, in the United States and Europe. Cinnamon, which comes from the bark of trees, is sold as solid sticks and powder with the country of origin rarely declared on the package label. There are two main types: Ceylon cinnamon (also known as "true" cinnamon) and cassia cinnamon. Ceylon grows in Sri Lanka (formerly Ceylon), the Seychelles, and Madagascar. Cassia generally comes from China and Indonesia. Both types can contain coumarin, a natural flavoring found in plants. Studies have linked ...
Rationale:. The narrow therapeutic range and wide inter-patient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable. As a result, patients require frequent monitoring to avert adverse effects and maintain therapeutic efficacy. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex 1 (VKORC1) jointly account for about 40% of the inter-individual variability in dose requirements. To date, several pharmacogenetic guided dosing algorithms for coumarin derivatives, predominately for warfarin, have been developed. However, the potential benefit of these dosing algorithms in terms of their safety and clinical utility has not been adequately investigated in randomised settings. Objective: To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with each of warfarin, acenocoumarol and phenprocoumon compared to a dosing regimen that ...
Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany. Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1] ...
... contains a glycoside (glycyrrhizin), flavonoids, asparagine, isoflavonoids, chalcones and coumarins. Purchase Douglas Labs Licorice Root-V (Deglycyrrhznd) 90 vcaps online with free shipping!
Methoxsalen (also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine) is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10 mg tablets, which are taken in the amount of 30 mg 75 minutes before a PUVA (psoralen + UVA) light treatment. Levels of individual patient PUVA exposure were originally determined using the Fitzpatrick scale. The scale was developed after patients demonstrated symptoms of phototoxicity after oral ingestion of Methoxsalen followed by PUVA therapy. Chemically, methoxsalen belongs to a class of organic natural molecules known as furanocoumarins. They consist of coumarin annulated with furan. It can also be injected and used topically. Methoxsalen is extracted from Ammi majus, a plant of the family Apiaceae. The ...
Abu-Mustafa, Effat A.; Fayez, M. B. E. (1961). "Natural Coumarins. I. Marmesin and Marmesinin, Further Products from the Fruits ...
Schönberg, Alexander; Badran, Nasry; Starkowsky, Nicolas A. (1953). "Furo-chromones and -Coumarins. VII. Degradation of ...
The main coumarin in limes is limettin which has manifold higher content in peels than in pulp. Persian limes have a higher ... Nigg HN, Nordby HE, Beier RC, Dillman A, Macias C, Hansen RC (1993). "Phototoxic coumarins in limes". Food Chem Toxicol. 31 (5 ... content of coumarins and potentially greater phototoxicity than do Key limes. Lime production in Mexico List of citrus fruits ... cocktails may develop phytophotodermatitis due to the high concentration of furocoumarins and other phototoxic coumarins in ...
The Kostanecki acylation is a method used in organic synthesis to form chromones or coumarins by acylation of O-hydroxyaryl ... Sethna, S. M.; Shah, N. M. (1945). "The Chemistry of Coumarins". Chemical Reviews. 36: 1. doi:10.1021/cr60113a001. v. ... or coumarin) Alvocidib (flavopiridol) Dimefline Flavoxate Allan-Robinson reaction Baker-Venkataraman rearrangement Gaspar, A.; ...
Schönberg, Alexander; Badran, Nasry; Starkowsky, Nicolas A. (1955). "Furo-chromones and -Coumarins. XII. Synthesis of Fraxinol ...
His interest in coumarins, a recently isolated compound at the time, led Bargellini to experiment with multi-component ... One hundred years later, the Bargellini reaction itself was used for the condensation of coumarins, an ironic twist to the ... Sen, Prabir K.; Biswas, Bidyut; Venkateswaran, Ramanathapuram V. (2005-12-12). "Bargellini condensation of coumarins. ...
Coumarins (vitamin K antagonists)Edit. Further information: Vitamin K antagonist. These oral anticoagulants are derived from ... The coumarins brodifacoum and difenacoum are used as rodenticides, but are not used medically. ... The traditional ones (warfarin, other coumarins and heparins) are in widespread use. Since the 2000s a number of new agents ... and they have been shown to be as good or possibly better than the coumarins with less serious side effects.[12] The newer ...
Several coumarins have been isolated from the roots, including one named merrillin. The alkaloid yuehchukene has been found in ... 1989). Coumarins of Merrillia caloxylon. Phytochemistry 28(2), 657-59. Kong, Y., et al. (1988). The biochemical systematics of ...
Also many other functional heterocycles are in good yields accessible from ethyl cyanoacetate, such as 3-substituted coumarin ... V.; Dangyan, M. T. (1980). "Synthesis of functionally substituted coumarins". Chem. Heterocycl. Compounds. 15 (9): 959-960. doi ...
... , also rendered æsculin or esculin, is a coumarin glucoside that naturally occurs in the trees horse chestnut (Aesculus ...
It also contains coumarins and limonoids. Cell cultures produce the coumarins umbelliferone, scopoletin, psoralen, xanthotoxin ... INIST:2179664 Steck, Warren; Bailey, B.K.; Shyluk, J.P.; Gamborg, O.L. (1971). "Coumarins and alkaloids from cell cultures of ... INIST:18469419 Srivastava, S. D.; Srivastava, S. K.; Halwe, K. (1998). "New coumarins and limonoids of Ruta graveolens". ...
... is a coumarin derivative found in the leaves of the Australian Willow (Geijera parviflora). It is a monoamine ... Lahey FN, Macleod JK (September 1967). "The coumarins of Geijera parviflora Lindl". Aust J Chem. 20 (9): 1943-55. doi:10.1071/ ...
HRAS Coumarin resistance; 122700; CYP2A6 Cousin syndrome; 260660; TBX15 Cowden disease; 158350; PTEN Cowden-like syndrome; ...
Coumarin Cui, WS; Tian, J; Ma, ZJ; Guo, YQ; Wang, JH; Li, X (2003). "A new isocoumarin from bark of Pellodendron chinense". ...
The chemistry of these plants has been studied, with several known and new coumarins isolated. One such coumarin from M. ... 2001). Three new coumarins from Micromelum integerrimum.[permanent dead link] Chinese Chemical Letters 12(7) 603-06.. ... Isolation and structural elucidation of new coumarins. Chemical and Pharmaceutical Bulletin - Tokyo 48(3), 334-38. He, H. P., ...
The leaves contain coumarins and sesquiterpene lactones. The sesquiterpenes are known to be costunolide, parthenolide, ... 10.1002/jps.2600700833 Coumarins and sesquiterpene lactones from Magnolia grandiflora leaves. Yang MH, Blunden G, Patel AV, ...
Coumarins from the Root of Seseli libanotis (L.) Koch. The Structure of Three New Coumarins" (PDF). Acta Chemica Scandinavica. ... Lemmich, John; Shabana, Marawan (11 April 1984). "Coumarin sulphates of Seseli libanotis". Phytochemistry. Elsevier. 23 (4): ...
2008). Two new coumarins from Euonymus hamiltonianus. Chemistry of Natural Compounds 44(1) 10-12. Tantray, M. A., et al. (2009 ... "Winter Glory" cultivar A number of novel chemical compounds have been isolated from this plant, including the coumarins ...
Coumarin citrus fruits, maize. Tyrosol olive oil. Hydroxytyrosol olive oil. Oleocanthal olive oil. Oleuropein olive oil. ...
US Patent US 3399195 A. Beyerle R, Stachel A, Nitz RE, Resag K (1970). Process for the production of coumarin derivatives. US ... US Patent US 3894015 A. Beyerle R, Stachel A (1976). Piperazino substituted coumarin derivatives. US Patent US 3959281 A. ... coumarin), and basically substituted 1H,3H)-quinazoline-2-thion-4-one derivatives, having excellent coronary dilator properties ...
... the coumarins aesculetin and scopoletin; the ellagitannins are roburins A and E, grandinin, vescalagin and castalagin.[37] ...
... originates from coumarins in the shikimate pathway; its biosynthesis is shown in the figure below. The aromatic ring ... It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of ... It exhibits the normal reactions of the lactone of coumarin, such as ring opening by alkali to give a coumarinic acid or ... does undergo substitution at the desired 6-position allowing the following synthesis of the coumarin system via a Gattermann- ...
Important representatives of this class are the coumarins. Likewise a 4-hydroxyl pyrylium compound is a γ-pyrone or pyran-4-one ...
... and Coumarins". Journal of Agricultural and Food Chemistry. 53 (6): 2009-2014. doi:10.1021/jf0484632. ISSN 0021-8561. Sumit ...
Kulkarni, Manohar V.; Kulkarni, Geeta M.; Lin, Chao-Hsiung; Sun, Chung-Ming (2006). "Recent Advances in Coumarins and 1- ... B. M. Hausen; M. Schmieder (1986). "The sensitizing capacity of coumarins (I)". Contact Dermatitis. 15 (3): 157-163. doi: ... The tanning activator coumarin is known to induce thymine dimers (cyclobutane pyrimidine dimers). Other Web sites state ... correctly that: "Coumarins produce photosensitivity therefore advise the patient to avoid direct sunlight after treatment. [1] ...
I. Isolation of a Series of Substituted Coumarins". Journal of the American Chemical Society. 79 (13): 3488-3491. doi:10.1021/ ...
Several coumarins were purified using normal open and preparative column and high performance liquid chromatographic methods ... Consequently, binding studies of sesquiterpen coumarin with ct-DNA are useful for the understanding of the reaction mechanism ... inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins. ... Several coumarins were purified using normal open and preparative column and high performance liquid chromatographic methods ...
... calopphyllolide and calophyllic acid and coumarin derivatives, phospho-amino acids. Saturated Fatty Acids (typically 22%): ...
Coumarin 1 mg solubilized in DMSO and Coumarin 250 µg solubilized in PEG expressed different response in the same experimental ... An UV spectral study of coumarin was performed to study the possible spectroscopic changes in the structure of coumarin in ... coumarin (Figure 5B) and PEG (Figure 5C) are exhibited. PEG has a lipophilic alkyl tail[35]that decreases the coumarin ... effect attributed to coumarin (1, 2-benzopirone), that is the main biomarker of guaco.[3] Coumarin and o-coumaric acid are ...
... which contains coumarin. tonka bean extract smells and tastes like vanilla, but coumarin has been shown to cause liver damage ...
Antimelanomic: coumarin. • Antimetastatic: coumarin. • Antimutagenic: anisaldehyde; cinnamaldehyde; cinnamyl-alcohol; coumarin ... Lymphocytogenic: coumarin. • Lymphokinetic: coumarin. • Ornithine-Decarboxylase-Inhibitor: ferulic-acid; limonene. • ... Antiedemic: catechin; coumarin; eugenol; syringaldehyde. • Antiinflammatory: catechin; cinnamaldehyde; coumarin; eugenol; ... Antitumor: benzaldehyde; coumarin; eugenol; ferulic-acid; limonene; salicylic-acid; van-illic-acid; vanillin. • Antiviral: ...
Some of the vanilla oil from Mexico may be mixed with tonga bean that contains coumarin, a harmful chemical that has been ...
... coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including ... Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, ... Coumarin as an Immunomodulator (G. Zlabinger).. Mode of Action of Coumarin in the Treatment of Thermal Injuries (N. Piller).. ... Analysis of Coumarins (D. Bogan, et al.).. Suggested Modes of Action of Coumarins and Some Comments on their Significance (R. ...
Coumarin Hydroxy Group Terpenoid Acetone Extract Axial Orientation V. L. Komarov Botanical Institute, Academy of Sciences of ...
Coumarin Hydroxy Group CD3OD Bathochromic Shift Xanthone All-Union Scientific-Research Institute of Medicinal Plants, Moscow. ... N. Sheinker, and A. A. Savina, The Spectra and Structure of Coumarins, Chromanes, and Xanthones [in Russian], Moscow (1975). ...
Other names: 2H-1-Benzopyran-2-one; cis-o-Coumarinic acid lactone; o-Hydroxycinnamic acid lactone; Benzo-«alpha»-pyrone; Coumarinic anhydride; Rattex; Tonka bean camphor; 1,2-Benzopyrone; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, «delta»-lactone; 2H-Benzo[b]pyran-2-one; o-Hydroxycinnamic lactone; Cinnamic acid, o-hydroxy-, «delta»-lactone; Cumarin; 2-Oxo-1,2-benzopyran; 2H-1-Benzopyran, 2-oxo-; o-Hydroxyzimtsaure-lacton; Kumarin; NCI C07103; NSC 8774; 2H-Chromen-2-one ...
All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. ... Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being ... In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for ... Evaluation of Halogenated Coumarins for Antimosquito Properties. Venugopala K. Narayanaswamy,1,2 Raquel M. Gleiser,3 Kabange ...
The fluorescence of coumarins, such as 7-hydroxycoumarin, is widely used as a research tool in polymer science. Coumarins are ... Several natural and synthetic coumarins and derivatives, such as coumarin glycosides, possess potent biological activities. ... Coumarin derivatives are found in antibiotic, antimitotic, immunomodulating, antiviral, anticancer, anti-inflammatory, ... Learn More about Coumarins
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coumarin synonyms, coumarin pronunciation, coumarin translation, English dictionary definition of coumarin. n. A fragrant ... Coumarin - definition of coumarin by The Free Dictionary https://www.thefreedictionary.com/coumarin ... coumarin. Also found in: Medical, Encyclopedia, Wikipedia. cou·ma·rin. (ko͞o′mər-ĭn). n.. A fragrant crystalline compound, C9H6 ... coumarin. (ˈkuːmərɪn) or cumarin. n. (Elements & Compounds) a white vanilla-scented crystalline ester, used in perfumes and ...
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
coumarin definition: a toxic, white crystalline substance, CHO, with the odor of vanilla, obtained from the tonka bean and ... Coumarin and its derivatives are widely used in perfumes, as anticoagulants, and as rodenticides. Chemical formula: C9H6O2. ... coumarin. cou·ma·rin. a toxic, white crystalline substance, CHO, with the odor of vanilla, obtained from the tonka bean and ... Origin of coumarin. French coumarine from coumarou tonka bean tree from Spanish coumarú from Portuguese cumaru from Tupí cumarú ...
The Panel concludes that there is evidence for a risk of interaction between glucosamine and coumarin anticoagulants in some ... The evidence for an interaction between glucosamine and coumarin anticoagulants is strengthened by the observation that in the ... There is insufficient information to conclude on a mechanism for an interaction between glucosamine and coumarin anticoagulants ... Nutrition and Allergies to provide a scientific statement on the safety of glucosamine for patients receiving coumarin ...
Testing Status of Methyl coumarin 10136-L. CASRN: 92-48-8. Formula: C10-H8-O2. Synonyms/Common Names. *6-Methyl-2H-1-benzopyran ...
This page features an image of a coumarin-diclofenac mixture. ... A naturally occurring compound found in many plants, coumarin ...
There are many different coumarin derivatives, including those that are naturally found and those that are synthesized. Natural ... Coumarin derivatives have been shown to possess anti-inflammatory and anticoagulant properties, but they can also be toxic in ... Although coumarin itself does not function as an anticoagulant - a substance that prevents blood clotting - it can be ... Coumarin derivatives are widely used in pharmaceutical and commercial applications due to their health properties. A compound ...
... Rodrigo Santos Aquino de Araújo,1 José Maria ... and in silico studies of coumarin derivatives with antifungal activity," International Journal of Molecular Sciences, vol. 14, ... characterisation and antibacterial activity studies of coumarins from Rhododendron lepidotum Wall. ex G. Don, Ericaceae," ... "Synthesis and characterization of new thiazolidinones containing coumarin moieties and their antibacterial and antioxidant ...
Coumarins consist of a large class of phenolic substances found in plants. Different pharmacologic effects of coumarins were ... One of these effects is cytotoxicity and apoptosis induction in cancerous cells by coumarins. In this chapter, the cytotoxic ... so regulation of Mcl-1 expression by coumarins could be one of the mechanisms of CLL chemotherapy. ... activity of coumarins and their role in Mcl-1 regulation are discussed. ...
7-(Diethylamino)coumarin-3-carbohydrazide, derivatizing agent for carboxylic acid detection (ab145377). ...
Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ... In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. ... In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids ... Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Antonella Fais 1,* , Marcella Corda 1. ...
Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to ... Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to ... What is the role of coumarins in deep venous thrombosis (DVT) prophylaxis for patients undergoing orthopedic surgery?. Updated ... Coumarins produce their anticoagulant effect by inhibiting the carboxylation necessary for biologic activity. ...
A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their ... Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins Q. Li, L. Wei, J. Zhang, G ... A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their ... These results demonstrated that the combination of chitosan and coumarins improved the antioxidant activity of chitosan ...
  • Some of the vanilla oil from Mexico may be mixed with tonga bean that contains coumarin, a harmful chemical that has been banned in food by the U.S. Food and Drug Administration. (freddabranyon.com)
  • History of the Development and Applications of Coumarin and Coumarin-related Compounds (I. Weinmann). (wiley.com)
  • Coumarins are a group of plant-derived polyphenolic compounds. (sigmaaldrich.com)
  • 17-19) While the phytochemical studies and bioactivity studies were mostly conducted with the coumarin compounds of the genus, we wanted to examine the flavonoid content of Heracleum pastinaca Fenzl (Figure 1), which is a tiny rare endemic plant mainly distributed in the inner and southwest region of Anatolia. (thefreedictionary.com)
  • The anticoagulant activity of coumarin derivatives can be toxic to humans if these compounds are ingested in excessive amounts. (wisegeek.com)
  • Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC 50 values of these compounds were measured. (mdpi.com)
  • Coumarin is often found in tobacco products and artificial vanilla substitutes, though it has been banned as a food additive in numerous countries since the mid- 20th century because it is moderately toxic to the liver and kidneys, with an LD 50 of 275 mg/kg - low compared to related compounds. (wikidoc.org)
  • The two new compounds were established as 7-hydroxy-6-methoxy-3,8-bis(3-methyl-2-butenyl) coumarin (1) and 7-hydroxy-6-methoxy-3-(3-methyl-2-butenyl) coumarin (2), on the basis of 1D and 2D NMR techniques. (semanticscholar.org)
  • Coumarins are the main bioactive compounds in Peucedanum praeruptorum Dunn, a common Chinese herbal medicine. (frontiersin.org)
  • In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative.These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9.However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. (nih.gov)
  • In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate. (nih.gov)
  • However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. (nih.gov)
  • Coumarin compounds constitute a class of secondary metabolites widely found in plants. (scielo.br)
  • 3-7 Coumarin compounds are usually employed as additive in dyes and sprays as well as in aromatization of foods. (scielo.br)
  • The principle is similar to that of dye lasers, which also amplify light using dissolved organic molecules--not proteins, but compounds such as coumarin dyes, derived from substances in grasses that smell like freshly mowed hay. (thefreedictionary.com)
  • The aim of this study was to synthesise a series of compounds out of pharmacophoric groups of donepezil and coumarin that will be able to inhibit both cholinesterases and MAO B. Four series of 5 compounds per series were synthesised. (uwc.ac.za)
  • The first series of compounds consisted of the coumarin moiety to which a 1,4-dibromo benzene moiety was attached. (uwc.ac.za)
  • The third series represented the coumarin moiety to which bromobenzyl-piperazine was attached and in the last series were compounds similar in structure to series 1 with an unsubstituted benzyl moiety as opposed to the dibromobenzyl moiety. (uwc.ac.za)
  • In vivo, tumour growth was reduced when nude mice grafted with HT1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. (nih.gov)
  • In this study, we designed and synthesized a novel coumarin derivative (C3007) for evaluating its in vitro and in vivo anti-SVCV effects. (medworm.com)
  • The palladium catalyst allows for the addition of an ester to a phenol resulting in a ring closure and product coumarin derivative. (odinity.com)
  • It is believed that the reaction, proposed in scheme 1, will be a more cost effect way of producing the product coumarin derivative than extraction from natural sources. (odinity.com)
  • More research will need to be done to increase the yield of the product coumarin derivative before determining whether it would be a cost effective method of production in an industrial setting. (odinity.com)
  • In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. (mdpi.com)
  • Michaelis-Menten, competitive inhibition, and site-directed mutagenesis studies identified exosite 2 as the site of binding for the most potent sulfated coumarin. (sdsc.edu)
  • Antithrombin inactivation of thrombin was impaired in the presence of the sulfated coumarins suggesting that allosteric partial inhibition arises from catalytic dysfunction of the active site. (sdsc.edu)
  • Two new coumarins (1) and (2), along with seven known coumarins 3-9, were isolated from the leaves and stems of Coriarianepalensis Wall. (semanticscholar.org)
  • Two new coumarins, 6-hydroxy-7-methyl-3-(4′-methoxyphenyl)-coumarin ( 1 ) and 6-hydroxy-5-methoxy-7-methyl-3-(4′-methoxyphenyl)-coumarin ( 2 ), together with five known coumarins ( 3-7 ), were isolated from the leaves of Nicotiana tabacum. (springer.com)
  • Also Coumarin market reports analyses market by different segments, companies, regions and countries over the forecast period 2017 to 2022. (beforeitsnews.com)
  • The presence of the azide allows the user to use Click Chemistry (a [3+cycloaddition reaction between alkynes and azides, using copper (I) iodide as a catalyst) to conjugate the Coumarin-Azide to a terminal alkyne-modified oligo with extremely high regioselectivity and efficiency (1,2). (e-oligos.com)
  • The biosynthesis of coumarin in plants is via hydroxylation , glycolysis and cyclization of cinnamic acid . (wikidoc.org)
  • Nevertheless, the genes involved in the biosynthesis of core structure of coumarin in P. praeruptorum have not been identified yet. (frontiersin.org)
  • Biochemical characterization of the recombinant proteins revealed that Pp4CL1 utilized p -coumaric and ferulic acids as its two main substrates for coumarin biosynthesis in P. praeruptorum . (frontiersin.org)
  • Godfrey coumarin biosynthesis of amino hydrogenated decaffeinated after incriminated. (tv-commu.info)
  • tobías saccular and reductive lining phenylisopropylamine synthesis of benzocaine its grumpy coumarin biosynthesis of amino rowelled caracolled pasta. (tv-commu.info)
  • aram recreating and not concealing his fake system systematized armor in a delicious coumarin biosynthesis of amino way. (tv-commu.info)
  • The name comes from a French term for the tonka bean , coumarou , one of the sources from which coumarin was first isolated as a natural product in 1820. (ipfs.io)
  • It has been shown that the expression of Mcl-1 in CLL is significantly associated with a failure to achieve complete remission following cytotoxic therapy, so regulation of Mcl-1 expression by coumarins could be one of the mechanisms of CLL chemotherapy. (intechopen.com)
  • In this chapter, the cytotoxic activity of coumarins and their role in Mcl-1 regulation are discussed. (intechopen.com)
  • Zhang H, Zhou R, Jun M, Bacay AF, Eyring K, Webb A, Carrico-Moniz D. Identification of the Factors Responsible for the Selective in vitro Cytotoxic Activity of Isoprenylated Coumarin Derivatives under Nutrient-deprived Conditions. (jcancer.org)
  • Cytotoxic properties of three isolated coumarin-hemiterpene ether derivatives from Artemisia armeniaca Lam', Iranian Journal of Pharmaceutical Research , 16(1), pp. 221-229. (ac.ir)
  • Psoralen: many furocoumarins have a furan band fused with a coumarin nucleus and are derivatives of psoralen. (silt3.com)
  • Synthesis of the labels with substituents at the 4 and 7 position of the coumarin nucleus were carried out. (lboro.ac.uk)
  • Three of the active drugs were propyl coumarin analogues (2a, 7 and 8), two were dipyranone or chromeno-coumarins (9 and 10), and one was a benzotripyranone with a coumarin nucleus (18). (usu.edu)
  • The benzopyrones can be subdivided into the benzoalfa- pyrones to which the coumarins belong and the benzo-gama-pyrones, of which the flavonoids are principal members. (who.int)
  • Coumarins are used as laser dye-sensitized photoinitiators, for incorporation into polymer chains by co-polymerization, in the estimation of polymer solvent effects, for various structural characterizations, in the monitoring of the releasing properties of poly(methylmethacrylate) nanospheres and for polymeric fluorescent solar collectors. (sigmaaldrich.com)
  • This work studied the fluorescent and solvatochromic properties of coumarin and its derivatives aiming to contribute in the elucidation of the excited state behavior of the molecule in solvent mixtures. (scielo.br)
  • Esculin, a fluorescent coumarin glucoside, is recognized by Suc transporters, including AtSUC2, which loads it into the phloem for translocation to sink tissues. (plantphysiol.org)
  • A coumarin-based fluorescent probe containing a thiol-reacting maleimide group was synthesized. (nus.edu.sg)
  • Coumarin (7-Hydroxycoumarin)-Azide is a fluorescent dye containing a terminal azide group. (e-oligos.com)
  • Clinical and Biological Observations Associated with Coumarins (R. Thornes). (wiley.com)
  • In addition, more genes and biological pathways were similarly affected by coumarin in hepatocytes cultured in modified medium and in vivo. (tudelft.nl)
  • Coumarins possess diverse biological and pharmaceutical properties, including anti-edema, anti-inflammatory and anti-tumour activities ( Hoult and Paya, 1996 ). (scialert.net)
  • Coumarins are naturally occurring molecules that are found in plants that have numerous uses in the medical field because of its biological activity. (odinity.com)
  • These results are in line with the pharmacokinetic profile of coumarin and suggest that MRP3 and MRP4 are the main transporters involved in the excretion of the coumarin metabolite 7-HC-G from liver and kidney. (aspetjournals.org)
  • A detailed analysis of the absorption and emission spectra of both ligands and complexes allows us to attribute the luminescent behaviour to the coumarin organic ligand. (rsc.org)
  • Pre-treatment with pyrazole, which exacerbated BHT-induced lung injury, did not affect pulmonary coumarin hydroxylase or 4-nitrophenol hydroxylase activity but increased that of PROD. (curehunter.com)
  • The coumarin molecule is changed through the addition of certain chemical groups into a substance called 4-hydroxycoumarin, which can in turn be transformed into drugs with anticoagulant properties. (wisegeek.com)
  • This article is about the sweet-smelling plant substance called coumarin. (ipfs.io)
  • Coumarins are a class of oral anticoagulant drugs, which act as antagonists to vitamin K. The mechanism of action is to interfere with the interaction between vitamin K and coagulation factors II, VII, IX, and X. Vitamin K acts as a cofactor at these levels. (medscape.com)
  • Coumarin and indanedione anticoagulant drugs are commonly used in the treatment of thromboembolic disorders. (annals.org)
  • O'REILLY RA, AGGELER PM. Surreptitious Ingestion of Coumarin Anticoagulant Drugs. (annals.org)
  • One of these effects is cytotoxicity and apoptosis induction in cancerous cells by coumarins. (intechopen.com)
  • Metabolism of coumarin toward active metabolites, coumarin-induced cytotoxicity, and gene expression modulation were more pronounced in hepatocytes cultured in modified medium compared with hepatocytes cultured in standard medium. (tudelft.nl)
  • In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis , a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. (hindawi.com)
  • A series of coumarin and pyranocoumarin analogues were evaluated in vitro for antiviral efficacy against measles virus (MV), strain Chicago. (usu.edu)
  • coumarin 7-hydroxylase and testosterone 15 alpha-hydroxylase increase concomitant with prominent diffuse cell necrosis. (curehunter.com)
  • In this review we describe the use of different coumarin derivatives, pharmacokinetic characteristics of these drugs and differences amongst the coumarins. (unboundmedicine.com)
  • These reports may in particular increase the use of esculetin in diets and drugs even above the approximate content of mixed coumarins in western diet reported by Lacy and O Kennedy (2004) . (scialert.net)
  • Coumarins are effective drugs for treatment and prevention of thromboembolic events. (uu.nl)
  • It is shown that, when nanoparticles are formed from complexes of lanthanide and yttrium ions, the coumarin-30 molecules from the solution are completely incorporated into the nanoparticles. (osapublishing.org)
  • Although coumarin itself does not function as an anticoagulant - a substance that prevents blood clotting - it can be chemically modified through natural or artificial processes to do so. (wisegeek.com)
  • Both types can contain coumarin, a natural flavoring found in plants. (redorbit.com)
  • With these other two reviews to hand, the reader will have immediate access to every plant coumarin ever known and should readily be able to determine, for example, if a coumarin just isolated is indeed a new natural plant product. (springer.com)
  • Coumarin contributes a pleasant note to many natural flavorings, including vanilla, but it primarily occurs in cassia. (sfgate.com)
  • Coumarins are a structurally diverse group of natural substances derives from plants that display a host of bioactivities. (edu.pl)
  • Natural Coumarins. (wikipedia.org)
  • A simple, facile, and convenient practical method for the room temperature one-pot synthesis of a series of potentially biologically active coumarin-3-carboxylic acids has been developed in water from the Knoevenagel condensation and intramolecular cyclization of diverse 2-hydroxybenzaldehydes with Meldrum's acid using either potassium carbonate or sodium azide as a commercially available, cheap, and eco-friendly catalyst. (lazeroids.com)
  • Potassium carbonate or sodium azide catalyzed one-pot synthesis of coumarin-3-carboxylic acids has been developed via Knoevenagel condensation and intramolecular cyclization of diverse 2-hydroxybenzaldehydes with Meldrum's acid in water at room temperature. (lazeroids.com)
  • The characterization and site-directed mutagenesis studies of Pp4CL1 lays a solid foundation for elucidating the biosynthetic mechanisms of coumarins in P. praeruptorum and provides further insights in understanding the structure-function relationships of this important family of proteins. (frontiersin.org)
  • As the L103A mutant is certainly Coumarin 30 not capable of PML reorganization this result shows that higher-order multimerization of E4-ORF3 could be necessary for the experience of the proteins. (healthandwellnesssource.org)
  • proteins binding research support this bottom line as confirmed by copurification Coumarin 30 of coexpressed WT and L103A proteins in and coimmunoprecipitation of WT·L103A E4-ORF3 complexes in mammalian cells. (healthandwellnesssource.org)
  • Even though the E4-ORF3 proteins stocks a common localization with PML in the nuclear matrix small fraction isolated from Ad-infected cells (9-11) the system root PML-NB Coumarin 30 reorganization by E4-ORF3 isn't known which is not really grasped how E4-ORF3 recruits various other cellular protein into these buildings. (healthandwellnesssource.org)
  • In this study, we investigated whether a hepatic in vitro system with improved metabolic competence enhances the predictability for coumarin-induced in vivo toxicity by using a toxicogenomics approach. (tudelft.nl)
  • Different pharmacologic effects of coumarins were reported. (intechopen.com)
  • Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign events such as gastrointestinal dysfunction, hypersensitivity dermatitides, drug fever, and alopecia. (annals.org)
  • Synthesis of Functionalized Coumarins', Iranian Journal of Chemistry and Chemical Engineering (IJCCE) , 30(4), pp. 19-22. (ac.ir)