The type species of KAPPAPAPILLOMAVIRUS. It is reported to occur naturally in cottontail rabbits in North America.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Benign epidermal proliferations or tumors; some are viral in origin.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Deoxyribonucleic acid that makes up the genetic material of viruses.
The functional hereditary units of VIRUSES.
Proteins found in any species of virus.
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
An order of small mammals comprising two families, Ochotonidae (pikas) and Leporidae (RABBITS and HARES). Head and body length ranges from about 125 mm to 750 mm. Hares and rabbits have a short tail, and the pikas lack a tail. Rabbits are born furless and with both eyes and ears closed. HARES are born fully haired with eyes and ears open. All are vegetarians. (From Nowak, Walker's Mammals of the World, 5th ed, p539-41)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.
The genus Lepus, in the family Leporidae, order LAGOMORPHA. Hares are born above ground, fully furred, and with their eyes and ears open. In contrast with RABBITS, hares have 24 chromosome pairs.
ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.
A species of DELTAPAPILLOMAVIRUS infecting cattle.

Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. (1/83)

In this study, cottontail rabbit papillomavirus infection of domestic rabbits was used as an animal model to develop papillomavirus early gene-based vaccines. Groups of rabbits were intracutaneously vaccinated with single papillomavirus early genes E1, E2, E6, and E7 or with a combination of these four genes. Only a fraction of rabbits were protected from subsequent viral challenge when vaccinated with the E1 or E6 gene. Viral tumor growth in those rabbits vaccinated with the E1 or E2 gene was suppressed compared to that in controls. In contrast, seven of nine rabbits vaccinated with the combination of the E1, E2, E6, and E7 genes were completely protected against viral challenge. These data indicated that intracutaneous genetic vaccination with the combination of the E1, E2, E6, and E7 genes can be an effective strategy for immunoprophylaxis of papillomavirus infection.  (+info)

Induction of E6/E7 expression in cottontail rabbit papillomavirus latency following UV activation. (2/83)

Latent human papillomavirus (HPV) infections are widespread in the genital and respiratory tracts and are a source of recurrent disease. This study used a cottontail rabbit papillomavirus (CRPV) model to determine the presence of E1, E6, and E7 transcripts in latent infection and to determine the temporal change in transcripts following UV activation. We found E1 transcripts in all latently infected sites but no detectable E6 and E7 transcripts, consistent with our earlier studies of HPV6/11 latency. These results suggest that this transcription pattern is broadly characteristic of latent papillomavirus infections. E6/E7 transcripts were detectable within 1 week of irradiation, with maximal induction (approximately 40% of sites) at 2 weeks postirradiation. Papillomas were induced in approximately 26% of irradiated sites after a 3- to 5-week lag. Sites that did not form papillomas by 3 months after irradiation were CRPV DNA positive but E6/E7 RNA negative. Thus, only a subset of latent infections can be induced to express E6/E7 transcripts and form papillomas. We propose that CRPV can be used to study the molecular processes regulating papillomavirus activation.  (+info)

Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. (3/83)

Rabbit oral papillomavirus (ROPV) infects mucosal tissues of domestic rabbits. The viral genomic sequence has been determined and the most related papillomavirus type was the cutaneous cottontail rabbit papillomavirus (CRPV). Homologies between the open reading frames (ORFs) of ROPV and CRPV, however, ranged from 68% amino acid identity for L1 to only 23% identity for E4. Shared features unique to the two rabbit viruses included a large E6 ORF and a small E8 ORF that overlapped the E6 ORF. Serological responses to ROPV L1 viruslike particles (VLPs) were detected in rabbits infected at either the genital or oral mucosa with ROPV. The antibody response was specific to intact ROPV L1 VLP antigen, was first detected at the time of late regression, and persisted at high levels for several months after complete regression. Both oral and genital lesions regressed spontaneously, accompanied by a heavy infiltrate of lymphocytes. ROPV infection of rabbit genital mucosa is a useful model to study host immunological responses to genital papillomavirus infections.  (+info)

Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model. (4/83)

A cottontail rabbit papillomavirus (CRPV) E6 DNA vaccine that induces significant protection against CRPV challenge was used in a superior vaccination regimen in which the cutaneous sites of vaccination were primed with an expression vector encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that induces differentiation and local recruitment of professional antigen-presenting cells. This treatment induced a massive influx of major histocompatibility complex class II-positive cells. In a vaccination-challenge experiment, rabbit groups were treated by E6 DNA vaccination, GM-CSF DNA inoculation, or a combination of both treatments. After two immunizations, rabbits were challenged with CRPV at low, moderate, and high stringencies and monitored for papilloma formation. As expected, all clinical outcomes were monotonically related to the stringency of the viral challenge. The results demonstrate that GM-CSF priming greatly augmented the effects of CRPV E6 vaccination. First, challenge sites in control rabbits (at the moderate challenge stringency) had a 0% probability of remaining disease free, versus a 50% probability in E6-vaccinated rabbits, and whereas GM-CSF alone had no effect, the interaction between GM-CSF priming and E6 vaccination increased disease-free survival to 67%. Second, the incubation period before papilloma onset was lengthened by E6 DNA vaccination alone or to some extent by GM-CSF DNA inoculation alone, and the combination of treatments induced additive effects. Third, the rate of papilloma growth was reduced by E6 vaccination and, to a lesser extent, by GM-CSF treatment. In addition, the interaction between the E6 and GM-CSF treatments was synergistic and yielded more than a 99% reduction in papilloma volume. Finally, regression occurred among the papillomas that formed in rabbits treated with the E6 vaccine and/or with GM-CSF, with the highest regression frequency occurring in rabbits that received the combination treatment.  (+info)

DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. (5/83)

Malignant progression is a life-threatening consequence of human papillomavirus-associated lesions. In this study, we tested the efficacy of papillomavirus early-gene-based vaccines for prevention of carcinoma development of papillomavirus-induced skin papillomas on rabbits. Rabbit skin papillomas were initiated by infection with cottontail rabbit papillomavirus (CRPV). The papillomas were allowed to grow for 3 months without any treatment intervention. Rabbits were then immunized by gene gun-mediated intracutaneous administration of four DNA plasmids encoding CRPV E1, E2, E6, and E7 genes, respectively. All eight control rabbits receiving vector alone developed invasive carcinoma within 8 to 13 months. In contrast, only two of eight vaccinated rabbits developed carcinoma at 12 and 15 months, respectively. Papilloma growth was suppressed in the majority of vaccinated rabbits but not completely eradicated. These results indicate that gene gun-mediated immunization with papillomavirus early genes may be a promising strategy for prevention of malignant progression of human papillomavirus-associated lesions in humans.  (+info)

High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression. (6/83)

The papillomavirus E2 protein plays an important role in viral transcriptional regulation and replication. We chose to study the cottontail rabbit papillomavirus (CRPV) E2 protein as a transcriptional regulator because of the availability of an animal model for papilloma formation, which may be relevant for human papillomavirus (HPV) infection and replication. We studied the effect of expression levels of E2 on the long control region, which contains transcriptional promoter and enhancer elements, and synthetic E2-dependent artificial promoters in which the E2 was the dominant factor in the transcriptional activation. These experiments indicated that high levels of E2 were inhibitory and low levels were stimulatory for transactivation. In addition, we showed that the complex formed between CRPV E2 and the cognate binding site was less stable than the complex formed between HPV E2 and the same cognate binding site. Furthermore, we showed that CRPV E2 binding to its transcriptional regulatory sequence was stabilized by other proteins such as E1, which produced increments in transcriptional activation of E2-dependent genes. The data may be used to define conditions in which the rabbit model can be used for the screening of drugs which are inhibitory to the HPV and CRPV replication and gene expression.  (+info)

Variation in the nucleotide sequence of cottontail rabbit papillomavirus a and b subtypes affects wart regression and malignant transformation and level of viral replication in domestic rabbits. (7/83)

We previously reported the partial characterization of two cottontail rabbit papillomavirus (CRPV) subtypes with strikingly divergent E6 and E7 oncoproteins. We report now the complete nucleotide sequences of these subtypes, referred to as CRPVa4 (7,868 nucleotides) and CRPVb (7,867 nucleotides). The CRPVa4 and CRPVb genomes differed at 238 (3%) nucleotide positions, whereas CRPVa4 and the prototype CRPV differed by only 5 nucleotides. The most variable region (7% nucleotide divergence) included the long regulatory region (LRR) and the E6 and E7 genes. A mutation in the stop codon resulted in an 8-amino-acid-longer CRPVb E4 protein, and a nucleotide deletion reduced the coding capacity of the E5 gene from 101 to 25 amino acids. In domestic rabbits homozygous for a specific haplotype of the DRA and DQA genes of the major histocompatibility complex, warts induced by CRPVb DNA or a chimeric genome containing the CRPVb LRR/E6/E7 region showed an early regression, whereas warts induced by CRPVa4 or a chimeric genome containing the CRPVa4 LRR/E6/E7 region persisted and evolved into carcinomas. In contrast, most CRPVa, CRPVb, and chimeric CRPV DNA-induced warts showed no early regression in rabbits homozygous for another DRA-DQA haplotype. Little, if any, viral replication is usually observed in domestic rabbit warts. When warts induced by CRPVa and CRPVb virions and DNA were compared, the number of cells positive for viral DNA or capsid antigens was found to be greater by 1 order of magnitude for specimens induced by CRPVb. Thus, both sequence variation in the LRR/E6/E7 region and the genetic constitution of the host influence the expression of the oncogenic potential of CRPV. Furthermore, intratype variation may overcome to some extent the host restriction of CRPV replication in domestic rabbits.  (+info)

Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences. (8/83)

We used the cottontail rabbit papillomavirus (CRPV) New Zealand White rabbit model to test a combination treatment of large established papillomas with intralesional cidofovir and DNA vaccination to cure sites and reduce recurrences. Intralesional 1% (wt/vol) (0.036 M) cidofovir treatment of rabbit papillomas led to elimination, or "cure," of the papillomas over a 6- to 8-week treatment period (N. D. Christenson, M. D. Pickel, L. R. Budgeon, and J. W. Kreider, Antivir. Res. 48:131-142, 2000). However, recurrences at periods from 1 to 8 weeks after treatment cessation were observed at approximately 50% of cured sites. DNA vaccinations with CRPV E1, E2, E6, and E7 were initiated either after or at the time of intralesional treatments, and the recurrence rates were observed. When DNA vaccinations were started after intralesional cures, recurrence rates were similar to those of vector-vaccinated rabbits. A small proportion of recurrent sites subsequently regressed (4 out of 10, or 40%) in the vaccinated group versus no regression of recurrences in the vector-immunized group (0 out of 19, or 0%), indicating partial effectiveness. In contrast, when DNA vaccinations were conducted during intralesional treatments, a significant reduction of recurrences (from 10 out of 19, or 53%, of sites in vector-immunized rabbits to 3 out of 20, or 15%, of sites in viral-DNA-immunized rabbits) was observed. DNA vaccination without intralesional treatments had a minimal effect on preexisting papillomas. These data indicated that treatment with a combination of antiviral compounds and specific immune stimulation may lead to long-term cures of lesions without the ensuing problem of papilloma recurrence.  (+info)

Papillomas can occur anywhere on the body, but they are most commonly found on the face, neck, and scalp. They may appear as small bumps or growths that look like a wart. In some cases, papillomas may be associated with human papillomavirus (HPV) infection.

Papillomas are typically diagnosed through a physical examination of the affected area. In some cases, a biopsy may be performed to confirm the diagnosis and rule out other potential causes. Treatment for papillomas usually involves removal of the growth through a minor surgical procedure or cryotherapy (freezing).

Papillomas are not cancerous and do not typically pose any long-term health risks. However, they may be unsightly and can cause psychological distress for some people. In these cases, treatment may be sought for cosmetic reasons. It is important to note that papillomas should not be confused with squamous cell carcinoma, a type of skin cancer that can resemble a papilloma in appearance but has the potential to be more aggressive and harmful.

Papillomavirus infections can be classified into two main categories: low-risk and high-risk. Low-risk papillomavirus infections typically cause benign growths such as common warts, which are usually harmless and resolve on their own over time. High-risk papillomavirus infections, on the other hand, can lead to serious health problems such as cancer, particularly cervical cancer in women and anal cancer in both men and women.

The most common form of papillomavirus infection is genital warts, which are caused by human papillomavirus (HPV). HPV is the most common sexually transmitted virus and affects both men and women. It is estimated that up to 80% of people will be infected with HPV at some point in their lifetime, but most will not develop any symptoms or complications.

Other forms of papillomavirus infections include plantar warts, which are common on the soles of the feet and palms of the hands, and flat warts, which are small, rough growths that can appear anywhere on the body.

Papillomavirus infections can be diagnosed through a variety of methods, including visual inspection, biopsy, and molecular tests such as PCR (polymerase chain reaction). Treatment options vary depending on the type and location of the infection, but may include cryotherapy (freezing), surgical removal, or topical medications. Vaccines are also available to protect against certain types of papillomaviruses, particularly HPV.

Overall, papillomavirus infections are a common and diverse group of conditions that can have significant health implications if left untreated or if they progress to more severe forms. Proper diagnosis and treatment are important for managing these infections and preventing long-term complications.



There are several different types of tumor viruses, including:

1. Human papillomavirus (HPV): This virus is responsible for causing cervical cancer and other types of cancer, such as anal, vulvar, vaginal, and penile cancer.
2. Hepatitis B virus (HBV): This virus can cause liver cancer, known as hepatocellular carcinoma (HCC).
3. Human immunodeficiency virus (HIV): This virus can increase the risk of developing certain types of cancer, such as Kaposi's sarcoma and lymphoma.
4. Epstein-Barr virus (EBV): This virus has been linked to the development of Burkitt lymphoma and Hodgkin's lymphoma.
5. Merkel cell polyomavirus (MCPyV): This virus is responsible for causing Merkel cell carcinoma, a rare type of skin cancer.
6. Human T-lymphotropic virus (HTLV-1): This virus has been linked to the development of adult T-cell leukemia/lymphoma (ATLL).

Tumor virus infections can be diagnosed through a variety of methods, including blood tests, imaging studies, and biopsies. Treatment for these infections often involves antiviral medications, chemotherapy, and surgery. In some cases, tumors may also be removed through radiation therapy.

It's important to note that not all tumors or cancers are caused by viruses, and that many other factors, such as genetics and environmental exposures, can also play a role in the development of cancer. However, for those tumor virus infections that are caused by a specific virus, early diagnosis and treatment can improve outcomes and reduce the risk of complications.

Overall, tumor virus infections are a complex and diverse group of conditions, and further research is needed to better understand their causes and develop effective treatments.

There are several types of warts, including:

* Common warts: These are the most common type of wart and appear as rough, bumped growths on the skin.
* Flat warts: These are smaller and smoother than common warts and can appear on the face, neck, or arms.
* Plantar warts: These are found on the soles of the feet and can be painful.
* Genital warts: These are a type of HPV infection that appears in the genital area and can be spread through sexual contact.

Warts are usually diagnosed by a healthcare provider based on their appearance. In some cases, a biopsy may be performed to confirm the diagnosis.

Treatment for warts depends on the type and location of the growth, as well as the patient's overall health. Some common treatment options include:

* Cryotherapy: This involves freezing the wart with liquid nitrogen to kill the infected cells.
* Cantharidin: A blistering agent made from the secretions of the blister beetle, it is applied to the wart and causes a painless blister to form under the wart, which eventually falls off.
* Salicylic acid: A common ingredient in over-the-counter wart removers, it works by dissolving the keratin protein that makes up the wart.
* Surgical removal: In some cases, surgical removal of the wart may be necessary if other treatments have been unsuccessful.
* Immunotherapy: This is a newer treatment for warts that uses a patient's own immune system to fight off the HPV infection. It involves applying a solution to the wart that stimulates the immune system and causes the wart to fall off.

It is important to note that while warts are usually harmless, they can be a sign of a weakened immune system, so it is important to consult with a healthcare professional if you have any concerns. Additionally, it's important to avoid using over-the-counter treatments for long periods of time or on multiple areas of the body, as they can cause skin irritation and scarring.

The Shope papilloma virus (SPV), also known as cottontail rabbit papilloma virus (CRPV) or Kappapapillomavirus 2, is a ... Therefore, the major host species of SPV is the cottontail rabbit of the western United States. Cottontail rabbits in Shope's ... Using a mutant cottontail rabbit papillomavirus (SPV) genome incapable of expressing the viral E4 protein, it has been shown ... Giri, Isabelle; Danos, Olivier; Yaniv, Moshe (March 1985). "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus ...
"Latent Infection Induced with Cottontail Rabbit Papillomavirus: A Model for Human Papillomavirus Latency". American Journal of ... Steinberg began her studies of human papillomaviruses (HPVs) and their role in diseases of the head and neck, especially ...
"Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV- ... Soon after Jian Zhou and Ian Frazer started work on the HPV vaccine, proposing that the proteins of the human papillomavirus ... She became interested in making vaccines, and started work on the human papillomavirus infection. ... "A controlled trial of a human papillomavirus type 16 vaccine". The New England Journal of Medicine. 347 (21): 1645-1651. doi: ...
Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts in its native host, the North American rabbit genus ... Christensen ND (2005). "Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ... CRPV, rabbit oral papillomavirus (ROPV) and canine oral papillomavirus (COPV) have also been used extensively for laboratory ... Four papillomaviruses are known to infect birds: Fringilla coelebs papillomavirus 1, Francolinus leucoscepus papillomavirus 1, ...
In 1933 Richard Shope and Edward Weston Hurst showed that warts from wild cottontail rabbits contained the Shope papilloma virus ... The human papillomavirus-16 (HPV-16) has been shown to lead to cervical cancer and other cancers, including head and neck ... "Human papillomavirus (HPV) and cervical cancer". WHO. June 2016. Archived from the original on 5 August 2016. Anjum T, Zohaib J ... Human papillomavirus infection is a major cause of cervical cancer, vulvar cancer, vaginal cancer, penis cancer, anal cancer, ...
... papillomavirus MeSH B04.280.535.600.650 - papillomavirus, bovine MeSH B04.280.535.600.660 - papillomavirus, cottontail rabbit ... papillomavirus MeSH B04.909.624.600.650 - papillomavirus, bovine MeSH B04.909.624.600.660 - papillomavirus, cottontail rabbit ... papillomavirus, bovine MeSH B04.909.204.210.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.204.210.655.600.690 - ... papillomavirus, bovine MeSH B04.909.574.204.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.574.204.655.600.690 - ...
Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis ... Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV ... His research has focused on papillomaviruses and their association with benign tumours and skin and cervical cancers. He is a ... Papilloma viruses: Possible role in human cancer », Cold Spring Harbor Conf. Cell Prolif, (1977) 4, p. 1043-68 Orth G, Favre M ...
... in cottontail rabbits was due to a filterable virur, later known as Shope papilloma virus, and showed in 1935 that the virus ... "Fluorescent antibody detection of the antigens of the Shope papilloma virus in papillomas of the wild and domestic rabbit". The ... Rous obliged and soon reported on the details Shope papilloma virus. From his initial study, he knew that such tumor can " ... Rous, Peyton; Beard, J. W. (1935-10-01). "The progression to carcinoma of virus-induced rabbit papillomas (Shope)". Journal of ...
References to horned rabbits may originate in sightings of rabbits affected by the Shope papilloma virus, named for Richard E. ... Shope initially examined wild cottontail rabbits that had been shot by hunters in Iowa and later examined wild rabbits from ... The Huichol oral tradition has passed down tales of a horned rabbit and of the deer getting horns from the rabbit. The rabbit ... A 13th-century Persian work depicts a rabbit with a single horn, like a unicorn. In Europe, the horned rabbit appeared in ...
Scope also discovered that virus infection caused fibroma in the cottontail rabbits he had hunted in New Jersey, and that a ... In 1933, Shope identified the Shope papillomavirus, which infects rabbits. His discovery later assisted other researchers to ... virus infection was also responsible for the papillomatosis in the cottontail rabbits he had observed in Iowa. By the last ... link the papilloma virus to warts and cervical cancer. He received the 1957 Albert Lasker Clinical Medical Research Award. In ...
A transactivator function of cottontail rabbit papillomavirus e2 is essential for tumor induction in rabbits.. Jeckel S; Huber ... 1. Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations.. Schneider M; ... High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression.. Fujii T; ... of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus.. Jeckel S; ...
However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how ... Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. ... The cottontail rabbit papillomavirus model of high-risk HPV-induced disease. Brandsma JL. Brandsma JL. Methods Mol Med. 2005; ... Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus. Cladel NM, Xu J, Peng X, Jiang P, ...
It is reported to occur naturally in cottontail rabbits in North America.. Terms. Cottontail rabbit papillomavirus Preferred ... 2007; see PAPILLOMAVIRUS, COTTONTAIL RABBIT 1997-2006, see PAPILLOMAVIRUS SYLVILAGI 1994-1996, see SHOPE PAPILLOMA VIRUS 1991- ... It is reported to occur naturally in cottontail rabbits in North America.. Entry Term(s). Papilloma Virus, Shope Papillomavirus ... Cottontail rabbit papillomavirus Preferred Concept UI. M0019793. Registry Number. txid10623. Scope Note. The type species of ...
We report a proof-of-principle study to monitor the viral DNA copy number using a newly established mouse papillomavirus ( ... To our knowledge, our study is the first in vivo study to sequentially monitor papillomavirus infection from mucosal anal, oral ... Brandsma J. L. 2005; The cottontail rabbit papillomavirus model of high-risk HPV-induced disease. Methods Mol Med 119:217-235[ ... Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
... wild cottontail rabbits. In 1975, Harald zur Hausen published the hypothesis that the human papillomavirus played a role in the ... Papillomavirus [papʺĭ-loʹmə-viʺrəs]. From the Latin papillo- ("nipple") + oma ("tumor"), papillomaviruses are nonenveloped DNA ... Infectious papillomatosis of rabbits. J Exp Med. 1933;58:607-24 . DOIPubMedGoogle Scholar ... Human papilloma viruses and cancer. Bibl Haematol. 1975; (. 58. ):569-71 .PubMedGoogle Scholar ...
Cottontail rabbit papillomavirus Entry term(s). Cottontail rabbit papillomaviruses Papilloma Virus, Shope Papillomavirus ... Cottontail rabbit papillomaviruses. Papilloma Virus, Shope. Papillomavirus sylvilagi. Shope Papilloma Virus. papillomaviruses, ... 2007; see PAPILLOMAVIRUS, COTTONTAIL RABBIT 1997-2006, see PAPILLOMAVIRUS SYLVILAGI 1994-1996, see SHOPE PAPILLOMA VIRUS 1991- ... Cottontail rabbit papillomavirus - Preferred Concept UI. M0019793. Scope note. The type species of KAPPAPAPILLOMAVIRUS. It is ...
It is reported to occur naturally in cottontail rabbits in North America.. Terms. Cottontail rabbit papillomavirus Preferred ... 2007; see PAPILLOMAVIRUS, COTTONTAIL RABBIT 1997-2006, see PAPILLOMAVIRUS SYLVILAGI 1994-1996, see SHOPE PAPILLOMA VIRUS 1991- ... It is reported to occur naturally in cottontail rabbits in North America.. Entry Term(s). Papilloma Virus, Shope Papillomavirus ... Cottontail rabbit papillomavirus Preferred Concept UI. M0019793. Registry Number. txid10623. Scope Note. The type species of ...
... cottontail rabbit papilloma virus, hepatitis B virus, bovine respiratory syncytial virus, Japanese encephalitis virus, Russian ... rabbit papillomavirus, showed that conformationally specific virus-neutralizing antibodies could be induced even though the ... Later studies of DNA vaccines that encoded proteins that were not normally targeted for secretion, such as L1 of cottontail ... papillomavirus L1, hepatitis C virus nucleocapsid, hepatitis B core protein, duck hepatitis B virus surface antigen, hepatitis ...
Cottontail rabbit papillomavirus B04.280.210.655.520 Lambdapapillomavirus B04.280.210.655.540 Mupapillomavirus B04.280.210.655. ... Cottontail rabbit papillomavirus B04.613.204.655.520 Lambdapapillomavirus B04.613.204.655.540 Mupapillomavirus B04.613.204.655. ... Human papillomavirus 6 B04.280.210.655.050.606.611 Human papillomavirus 11 B04.280.210.655.050.616 Human papillomavirus 16 ... Human papillomavirus 6 B04.613.204.655.050.606.611 Human papillomavirus 11 B04.613.204.655.050.616 Human papillomavirus 16 ...
Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that ... Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced ... Papillomavirus de Coelho Cottontail/metabolismo , Papiloma/terapia , Proteínas não Estruturais Virais/uso terapêutico , Animais ... Papillomavirus de Coelho Cottontail/fisiologia , Papiloma/patologia , Papiloma/virologia , RNA Mensageiro/metabolismo , Coelhos ...
Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ...
Mouse papillomavirus type 1 and cotton-tail rabbit papillomavirus infection models are two gold-standard preclinical animal ... 1) Papillomavirus infection and viral and host gene expression. Human papillomavirus type 16 (HPV16) or 18 (HPV18) infection, ... Dong H, Shu X, Xu Q, Zhu C, Kaufmann AM, Zheng ZM, Albers AE, Qian X. Current Status of Human Papillomavirus-Related Head and ... Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining. PLoS ...
Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. ... Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein. JVirol 70:3355- ... Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus ... Characterization of transformation function of cottontail rabbit papillomavirus E5 and E8 genes. Virology 251:253-263. ...
5. Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
A10.690.637.750 Papillomavirus, Cottontail Rabbit B4.280.535.600.660 B4.280.535.500.150 B4.909.204.210.655.600.660 B4.909. ... Replaced for 2007 by Cottontail rabbit papillomavirus) Parametritis C13.371.56.750.750 C13.351.500.56.750.750 Parapsychology ... B4.909.624.50.606.611 Human papillomavirus 16 B4.280.535.600.690.616 B4.280.535.50.616 B4.909.204.210.655.600.690.616 B4.909. ... B4.909.624.50.618 Human papillomavirus 6 B4.280.535.600.690.606 B4.280.535.50.606 B4.909.204.210.655.600.690.606 B4.909.204.210 ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
Rabbit papilloma virus has occasionally been maintained by repeated passages in the domestic rabbit (Shope, 1935). One such ... Reversion of adaptation to domestic rabbit by passage through cottontail. Brit. J. Cancer 2:375-380. Suope, R. E., 1935, Serial ... Yet, in the classical cases of masking, for example, with rabbit papil- loma virus in domestic rabbit, virus particles seem to ... domestic rabbit- adapted strain lost its adaptation in a single passage in cottontail hare (Selbie et al., 1948). The condi- ...
Cottontail rabbit papillomavirus Coturnix Cotyledon Cough Coumaphos Coumaric Acids Coumarins Coumestrol Counseling Counselors ... Bovine papillomavirus 1 Bovine papillomavirus 4 Bovine Respiratory Disease Complex Bovine Virus Diarrhea-Mucosal Disease ...
"Rabbits dont grow antlers. They grow tumors that look like antlers. Its called the Shope papilloma virus. Its common and ... I panned my beam up his cotton tail, his rocky spine, and broad shoulders. The creature had the body of a giant, the horns of a ... A bulky bipedal beast, with the face of a rabbit, and antlers that glowed like charcoal. Its nose turned in our direction and ... Stumper was a stuffed rabbit with antlers. An original Herricks brothers Jackalope. A classic piece of chimera taxidermy. ...
In total, 55 desert cottontail rabbits (Sylvilagus audubonii) (Baird) and 2 black-tailed jackrabbits (Lepus californicus) (Gray ... Universal hepatitis B birth dose; human papillomavirus vaccine; rotavirus vaccine; and diphtheria, tetanus, and pertussis- ... Lagomorphs-principally rabbits and hares-have been implicated as hosts for vectors and reservoirs for pathogens associated with ... Euhoplopsyllus glacialis affinis Baker (Siphonaptera: Pulicidae) fleas were collected from 72% of rabbits and 1 jackrabbit from ...
This article provides a quick overview of what is currently known about the lifecycle of human papillomaviruses as well as the ... Cottontail rabbit papillomavirus; HPV: Human papillomavirus.. References. ... Is the Human Papillomavirus Vaccine Effective? 0.25 CME / CE / ABIM MOC Credits Clinical Review ... Attachment of papillomaviruses to heparan sulfate proteoglycans causes exposure of a furin cleavage site at the N-terminus of ...
Papillomavirus, Cottontail Rabbit. Cottontail rabbit papillomavirus. Reovirus 3. Mammalian orthoreovirus 3. Sarcoma Viruses, ...
Cottontail Rabbit Papillomavirus E1 and E2 Proteins Mutually Influence Their Subcellular Localizations.. Schneider M; ... 3. AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit ... 2. Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase ... 5. The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes ...
A papilloma has been observed in wild cottontail rabbits and has been found to be transmissible to both wild and domestic ... rabbits. The clinical and pathological pictures of the condition have been described. It has been found that the causative ... Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus. Cladel NM, Xu J, Peng X, Jiang P, ... INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY ...
Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV ... Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 1995;. 87(11): 796-802. ... Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 1991;. 184:9-13. [Tables]. Table 1. The 1991 Bethesda ... Genital papillomaviruses and related neoplasms. 1st ed.. New York, NY: Raven Press, 1991. Delgado G, Bundy BN, Fowler WC Jr, et ...
Papillomavirus, Cottontail Rabbit. Cottontail rabbit papillomavirus. Reovirus 3. Mammalian orthoreovirus 3. Sarcoma Viruses, ...
Cottontail rabbit papillomavirus (organism) {56794007 , SNOMED-CT } Application Version: 4.0.6.6. Content Version: 2021.03.26. ...
Papillomavirus, Cottontail Rabbit. Cottontail rabbit papillomavirus. Reovirus 3. Mammalian orthoreovirus 3. Sarcoma Viruses, ...
Human Papillomavirus Viruses [B04.280.210.655.450] * Kappapapillomavirus [B04.280.210.655.500] * Cottontail rabbit ... Human Papillomavirus Viruses [B04.613.204.655.450] * Kappapapillomavirus [B04.613.204.655.500] * Cottontail rabbit ... COTTONTAIL RABBIT PAPILLOMAVIRUS is the type species.. Terms. Kappapapillomavirus Preferred Term Term UI T650022. Date08/31/ ... COTTONTAIL RABBIT PAPILLOMAVIRUS is the type species.. Registry Number. txid325457. Public MeSH Note. 2007. History Note. 2007 ...
... showed efficacy against papillomavirus-induced warts in the cottontail rabbit. Basic Research in Immunology and Infectious ... and rabbit and nude mouse models for papillomavirus infections. Several compounds have shown promising effectiveness in the ... Besides the herpesvirus family of diseases, genital warts, caused by specific human papillomaviruses, are another significant ... of NIAIDs DMID also supports clinical trials of experimental therapies for severe herpesvirus and papillomavirus infections. ...
... by using rabbits with cottontail rabbit papillomavirus-induced tumors and the canine larynx as model systems. DESIGN: ... agent for destruction of papillomas in cottontail rabbit papillomavirus-infected Dutch belted and New Zealand rabbits. Three ... The rabbit skin damage threshold was 40 to 60 J/cm2 at 6 days. The canine laryngeal edema and erythema thresholds were 50 to 70 ... Efficacy of intravenous delta-aminolaevulinic acid photodynamic therapy on rabbit papillomas. Lofgren, L A; Ronn, A M; Nouri, M ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
Cottontail rabbit papillomavirus B4.280.535.500.150 B4.280.210.655.500.150 B4.909.204.210.655.500.150 B4.613.204.655.500.150 ... Human papillomavirus 31 B4.280.535.50.631 B4.280.210.655.50.616.500 B4.613.204.655.50.616.500 Human papillomavirus 6 B4.280. ... Human Papillomavirus DNA Tests E5.393.462 Human T-lymphotropic virus 1 B4.909.574.807.200.725.400 B4.613.807.200.725.400 B4.909 ... Rabbit B4.909.204.210.600.250 B4.280.210.600.250 B4.909.204.783.160.500.250 B4.613.204.600.250 B4.909.574.204.600.250 Ficusin ...
Risk of Guillain-Barre Syndrome following quadrivalent human papillomavirus vaccine in the Vaccine Safety DatalinkExternal. Gee ... The white-footed mouse (Peromyscus leucopus), house mouse (Mus musculus) marsh rice rat (Oryzomys palustris), marsh rabbit ( ... Sylvilagus palustris), eastern cottontail (Sylvilagus floridanus) and six-lined racerunner (Cnemidophorus sexlineatus) were ...
... pf16 septate depalmitoylation unskilled pf12 pf11 septata spa32 terpestacin pdme citreus hnrpk isoleucyl citreum rabbit ... galioides castration brotherhood ballast opisthotonus azorense nonvenomous hs19 hs15 hs14 liners hs12 hs10 papillomaviruses ... kleptomania arietinum ccr2b ccr2a leucokinin spaca3 abarenicola hexosyl cinnamtannin aphelasterias puellus zorba cottontail ... praneem pseudanabaena triangle allerton unisystem beraprost hynic varanus gasterosteus superfine stability regulator rabbits ...
  • 16. A transactivator function of cottontail rabbit papillomavirus e2 is essential for tumor induction in rabbits. (nih.gov)
  • 1998. Characterization of transformation function of cottontail rabbit papillomavirus E5 and E8 genes. (nih.gov)
  • 11. The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site. (nih.gov)
  • Cell transformation by the E5/E8 protein of bovine papillomavirus type 4. (nih.gov)
  • The first animal papillomavirus was described in 1933 by Richard Shope, who researched papillomata in "warty" wild cottontail rabbits. (cdc.gov)
  • Genomic structure of the cottontail rabbit (Shope) papillomavirus. (nih.gov)
  • From the Latin papillo- ("nipple") + oma ("tumor"), papillomaviruses are nonenveloped DNA viruses that induce exophytic lesions of the skin and mucous membranes. (cdc.gov)
  • The E10 ORF was named in July 2016, based on suggestions from senior members of the papillomavirus community at the DNA Tumor Virus Conference in Montreal. (nih.gov)
  • We report a proof-of-principle study to monitor the viral DNA copy number using a newly established mouse papillomavirus (MmuPV1) mucosal infection model. (microbiologyresearch.org)
  • To our knowledge, our study is the first in vivo study to sequentially monitor papillomavirus infection from mucosal anal, oral and vaginal tracts in a preclinical model. (microbiologyresearch.org)
  • 1) Papillomavirus infection and viral and host gene expression. (nih.gov)
  • Human papillomavirus type 16 (HPV16) or 18 (HPV18) infection, acquired primarily via sexual transmission, is widely recognized as a leading cause of cervical and anal cancer as well as oropharyngeal cancer. (nih.gov)
  • Mouse papillomavirus type 1 and cotton-tail rabbit papillomavirus infection models are two gold-standard preclinical animal models for studying HPV-associated infections and tumors. (nih.gov)
  • 14. Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication. (nih.gov)
  • Control of viral replication and transcription by the papillomavirus E8^E2 protein. (nih.gov)
  • In 1975, Harald zur Hausen published the hypothesis that the human papillomavirus played a role in the etiology of cervical cancer, work for which he was awarded the Nobel Prize in Physiology or Medicine in 2008. (cdc.gov)
  • 17. The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment. (nih.gov)
  • 20. Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. (nih.gov)
  • The nucleotide sequence and genome organization of bovine papillomavirus type 4. (nih.gov)
  • 10. High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression. (nih.gov)
  • At this point, E10 ORFs are only annotated in PaVE for Xi and Kappa papillomaviruses, since there is published evidence for the function of these proteins in these viruses. (nih.gov)
  • 8. Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions. (nih.gov)
  • 15. Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins. (nih.gov)
  • 19. Identification of the E9/E2C cDNA and functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus. (nih.gov)
  • 2. Mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 E1 DNA helicase to promote efficient nuclear import. (nih.gov)
  • 3. Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein. (nih.gov)
  • 4. Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction. (nih.gov)
  • 5. Human papillomavirus type 31 replication modes during the early phases of the viral life cycle depend on transcriptional and posttranscriptional regulation of E1 and E2 expression. (nih.gov)
  • 9. Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase. (nih.gov)
  • 12. Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. (nih.gov)
  • 13. The hinge of the human papillomavirus type 11 E2 protein contains major determinants for nuclear localization and nuclear matrix association. (nih.gov)
  • 18. Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA. (nih.gov)
  • Anorectal human papillomavirus: current concepts. (microbiologyresearch.org)
  • The prevalence of human papillomavirus in colorectal adenomas and adenocarcinomas: a systematic review and meta-analysis. (microbiologyresearch.org)
  • Human papillomavirus in the HIV-infected host: epidemiology and pathogenesis in the antiretroviral era. (microbiologyresearch.org)
  • Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes. (nih.gov)
  • 6. Nuclear import of bovine papillomavirus type 1 E1 protein is mediated by multiple alpha importins and is negatively regulated by phosphorylation near a nuclear localization signal. (nih.gov)
  • Analysis of the transforming functions of bovine papillomavirus type 4. (nih.gov)
  • 5. Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system. (tuftsmedicalcenter.org)
  • 7. Acetylation of E2 by P300 Mediates Topoisomerase Entry at the Papillomavirus Replicon. (nih.gov)
  • The B subgroup bovine papillomaviruses lack an identifiable E6 open reading frame. (nih.gov)
  • Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. (nih.gov)
  • A papilloma has been observed in wild cottontail rabbits and has been found to be transmissible to both wild and domestic rabbits. (nih.gov)
  • The first animal papillomavirus was described in 1933 by Richard Shope, who researched papillomata in "warty" wild cottontail rabbits. (cdc.gov)
  • 2. Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway. (nih.gov)
  • 2002. Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits. (nih.gov)
  • Infectious papillomatosis of rabbits. (cdc.gov)
  • Both invasive cervical cancers and precursor lesions have been firmly associated with the presence of human papillomavirus (HPV) DNA. (nih.gov)
  • From the Latin papillo- ("nipple") + oma ("tumor"), papillomaviruses are nonenveloped DNA viruses that induce exophytic lesions of the skin and mucous membranes. (cdc.gov)
  • A genus of DNA viruses in the family PAPILLOMAVIRIDAE , causing cutaneous and mucosal lesions in rabbits. (nih.gov)
  • Cell transformation by the E5/E8 protein of bovine papillomavirus type 4. (nih.gov)
  • Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes. (nih.gov)
  • The B subgroup bovine papillomaviruses lack an identifiable E6 open reading frame. (nih.gov)
  • The nucleotide sequence and genome organization of bovine papillomavirus type 4. (nih.gov)
  • Analysis of the transforming functions of bovine papillomavirus type 4. (nih.gov)
  • At this point, E10 ORFs are only annotated in PaVE for Xi and Kappa papillomaviruses, since there is published evidence for the function of these proteins in these viruses. (nih.gov)
  • Rabbits carrying experimentally produced papillomata are partially or completely immune to reinfection and, furthermore, their sera partially or completely neutralize the causative virus. (nih.gov)
  • The disease is transmissible in series through wild rabbits and virus of wild rabbit origin is readily transmissible to domestic rabbits, producing in this species papillomata identical in appearance with those found in wild rabbits. (nih.gov)
  • 11. Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP. (nih.gov)
  • In 1975, Harald zur Hausen published the hypothesis that the human papillomavirus played a role in the etiology of cervical cancer, work for which he was awarded the Nobel Prize in Physiology or Medicine in 2008. (cdc.gov)
  • E10 is now designated as an ORF that either overprints the E6 ORF, or is encoded in this region (in the absence of an E6 gene) in certain papillomaviruses. (nih.gov)
  • 3. AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. (nih.gov)
  • Control of viral replication and transcription by the papillomavirus E8^E2 protein. (nih.gov)
  • 1996. Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein. (nih.gov)
  • Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. (nih.gov)
  • The virus of infectious papillomatosis is not related immunologically to either the virus of infectious fibroma or to that of infectious myxoma of rabbits. (nih.gov)
  • The E10 ORF was named in July 2016, based on suggestions from senior members of the papillomavirus community at the DNA Tumor Virus Conference in Montreal. (nih.gov)