Cottontail rabbit papillomavirus: The type species of KAPPAPAPILLOMAVIRUS. It is reported to occur naturally in cottontail rabbits in North America.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Tumor Virus Infections: Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.Warts: Benign epidermal proliferations or tumors; some are viral in origin.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Viral Structural Proteins: Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Genes, Viral: The functional hereditary units of VIRUSES.Viral Proteins: Proteins found in any species of virus.Vaccines, DNA: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.Lagomorpha: An order of small mammals comprising two families, Ochotonidae (pikas) and Leporidae (RABBITS and HARES). Head and body length ranges from about 125 mm to 750 mm. Hares and rabbits have a short tail, and the pikas lack a tail. Rabbits are born furless and with both eyes and ears closed. HARES are born fully haired with eyes and ears open. All are vegetarians. (From Nowak, Walker's Mammals of the World, 5th ed, p539-41)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Human papillomavirus 16: A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.Hares: The genus Lepus, in the family Leporidae, order LAGOMORPHA. Hares are born above ground, fully furred, and with their eyes and ears open. In contrast with RABBITS, hares have 24 chromosome pairs.Papillomavirus E7 Proteins: ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.Bovine papillomavirus 1: A species of DELTAPAPILLOMAVIRUS infecting cattle.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Carps: Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Cyprinidae: A family of freshwater fish comprising the minnows or CARPS.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.ConnecticutTheilovirus: A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Schools: Educational institutions.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Chromosomes, Artificial, Human: DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful replication, propagation to and maintainance in progeny human cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Illusions: The misinterpretation of a real external, sensory experience.Animal Experimentation: The use of animals as investigational subjects.Lambdapapillomavirus: A genus of DNA viruses in the family papillomaviridae, causing mucosal and cutaneous lesions in cats and dogs. Canine oral papillomavirus is the type species.Malta: An independent state consisting of three islands in the Mediterranean Sea, south of Sicily. Its capital is Valetta. The major island is Malta, the two smaller islands are Comino and Gozo. It was a Phoenician and Carthaginian colony, captured by the Romans in 218 B.C. It was overrun by Saracens in 870, taken by the Normans in 1090, and subsequently held by the French and later the British who allotted them a dominion government in 1921. It became a crown colony in 1933, achieving independence in 1964. The name possibly comes from a pre-Indoeuropean root mel, high, referring to its rocks, but a more picturesque origin derives the name from the Greek melitta or melissa, honey, with reference to its early fame for its honey production. (From Webster's New Geographical Dictionary, 1988, p719 & Room, Brewer's Dictionary of Names, 1992, p330)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Desulfovibrio: A genus of gram-negative, anaerobic, rod-shaped bacteria capable of reducing sulfur compounds to hydrogen sulfide. Organisms are isolated from anaerobic mud of fresh and salt water, animal intestines, manure, and feces.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Serbia: A republic located south of HUNGARY, west of ROMANIA and BULGARIA, and part of the former YUGOSLAVIA. The capital is Belgrade.ArchivesEndogenous Retroviruses: Retroviruses that have integrated into the germline (PROVIRUSES) that have lost infectious capability but retained the capability to transpose.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Human T-lymphotropic virus 1: A strain of PRIMATE T-LYMPHOTROPIC VIRUS 1 isolated from mature T4 cells in patients with T-lymphoproliferation malignancies. It causes adult T-cell leukemia (LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED), T-cell lymphoma (LYMPHOMA, T-CELL), and is involved in mycosis fungoides, SEZARY SYNDROME and tropical spastic paraparesis (PARAPARESIS, TROPICAL SPASTIC).Melanesia: The collective name for the islands of the Pacific Ocean northeast of Australia, including NEW CALEDONIA; VANUATU; New Hebrides, Solomon Islands, Admiralty Islands, Bismarck Archipelago, FIJI, etc. Melanesia (from the Greek melas, black + nesos, island) is so called from the black color of the natives who are generally considered to be descended originally from the Negroid Papuans and the Polynesians or Malays. (From Webster's New Geographical Dictionary, 1988, p748 & Room, Brewer's Dictionary of Names, 1992, p344)JapanGene Products, tax: Transcriptional trans-acting proteins of the promoter elements found in the long terminal repeats (LTR) of HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The tax (trans-activator x; x is undefined) proteins act by binding to enhancer elements in the LTR.Leukemia-Lymphoma, Adult T-Cell: Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Fluorescence: The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.Carboxypeptidase U: A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Perissodactyla: An order of ungulates having an odd number of toes, including the horse, tapir, and rhinoceros. (Dorland, 27th ed)Penile Neoplasms: Cancers or tumors of the PENIS or of its component tissues.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Wilderness: Environment un-modified by human activity. Areas in which natural processes operate without human interference.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).RING Finger Domains: A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.Wilderness Medicine: Skills and knowledge required for assessment and treatment of traumatic, environmental, and medical emergencies in remote geographic or wilderness environments.Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Cervical Intraepithelial Neoplasia: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)T-Lymphocytes, Helper-Inducer: Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.Nobel PrizeCodon: A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).Software: Sequential operating programs and data which instruct the functioning of a digital computer.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Eritrea: A country of eastern Africa, west of the Red Sea, bordered west and northwest by SUDAN, and south by ETHIOPIA. Its capital is Asmara.Physicians: Individuals licensed to practice medicine.Lawyers: Persons whose profession is to give legal advice and assistance to clients and represent them in legal matters. (American Heritage Dictionary, 3d ed)Child Advocacy: Promotion and protection of the rights of children; frequently through a legal process.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Neisseria gonorrhoeae: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.Pelvic Inflammatory Disease: A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.Silver: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Cancer Vaccines: Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Public Health Administration: Management of public health organizations or agencies.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. (1/83)

In this study, cottontail rabbit papillomavirus infection of domestic rabbits was used as an animal model to develop papillomavirus early gene-based vaccines. Groups of rabbits were intracutaneously vaccinated with single papillomavirus early genes E1, E2, E6, and E7 or with a combination of these four genes. Only a fraction of rabbits were protected from subsequent viral challenge when vaccinated with the E1 or E6 gene. Viral tumor growth in those rabbits vaccinated with the E1 or E2 gene was suppressed compared to that in controls. In contrast, seven of nine rabbits vaccinated with the combination of the E1, E2, E6, and E7 genes were completely protected against viral challenge. These data indicated that intracutaneous genetic vaccination with the combination of the E1, E2, E6, and E7 genes can be an effective strategy for immunoprophylaxis of papillomavirus infection.  (+info)

Induction of E6/E7 expression in cottontail rabbit papillomavirus latency following UV activation. (2/83)

Latent human papillomavirus (HPV) infections are widespread in the genital and respiratory tracts and are a source of recurrent disease. This study used a cottontail rabbit papillomavirus (CRPV) model to determine the presence of E1, E6, and E7 transcripts in latent infection and to determine the temporal change in transcripts following UV activation. We found E1 transcripts in all latently infected sites but no detectable E6 and E7 transcripts, consistent with our earlier studies of HPV6/11 latency. These results suggest that this transcription pattern is broadly characteristic of latent papillomavirus infections. E6/E7 transcripts were detectable within 1 week of irradiation, with maximal induction (approximately 40% of sites) at 2 weeks postirradiation. Papillomas were induced in approximately 26% of irradiated sites after a 3- to 5-week lag. Sites that did not form papillomas by 3 months after irradiation were CRPV DNA positive but E6/E7 RNA negative. Thus, only a subset of latent infections can be induced to express E6/E7 transcripts and form papillomas. We propose that CRPV can be used to study the molecular processes regulating papillomavirus activation.  (+info)

Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. (3/83)

Rabbit oral papillomavirus (ROPV) infects mucosal tissues of domestic rabbits. The viral genomic sequence has been determined and the most related papillomavirus type was the cutaneous cottontail rabbit papillomavirus (CRPV). Homologies between the open reading frames (ORFs) of ROPV and CRPV, however, ranged from 68% amino acid identity for L1 to only 23% identity for E4. Shared features unique to the two rabbit viruses included a large E6 ORF and a small E8 ORF that overlapped the E6 ORF. Serological responses to ROPV L1 viruslike particles (VLPs) were detected in rabbits infected at either the genital or oral mucosa with ROPV. The antibody response was specific to intact ROPV L1 VLP antigen, was first detected at the time of late regression, and persisted at high levels for several months after complete regression. Both oral and genital lesions regressed spontaneously, accompanied by a heavy infiltrate of lymphocytes. ROPV infection of rabbit genital mucosa is a useful model to study host immunological responses to genital papillomavirus infections.  (+info)

Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model. (4/83)

A cottontail rabbit papillomavirus (CRPV) E6 DNA vaccine that induces significant protection against CRPV challenge was used in a superior vaccination regimen in which the cutaneous sites of vaccination were primed with an expression vector encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that induces differentiation and local recruitment of professional antigen-presenting cells. This treatment induced a massive influx of major histocompatibility complex class II-positive cells. In a vaccination-challenge experiment, rabbit groups were treated by E6 DNA vaccination, GM-CSF DNA inoculation, or a combination of both treatments. After two immunizations, rabbits were challenged with CRPV at low, moderate, and high stringencies and monitored for papilloma formation. As expected, all clinical outcomes were monotonically related to the stringency of the viral challenge. The results demonstrate that GM-CSF priming greatly augmented the effects of CRPV E6 vaccination. First, challenge sites in control rabbits (at the moderate challenge stringency) had a 0% probability of remaining disease free, versus a 50% probability in E6-vaccinated rabbits, and whereas GM-CSF alone had no effect, the interaction between GM-CSF priming and E6 vaccination increased disease-free survival to 67%. Second, the incubation period before papilloma onset was lengthened by E6 DNA vaccination alone or to some extent by GM-CSF DNA inoculation alone, and the combination of treatments induced additive effects. Third, the rate of papilloma growth was reduced by E6 vaccination and, to a lesser extent, by GM-CSF treatment. In addition, the interaction between the E6 and GM-CSF treatments was synergistic and yielded more than a 99% reduction in papilloma volume. Finally, regression occurred among the papillomas that formed in rabbits treated with the E6 vaccine and/or with GM-CSF, with the highest regression frequency occurring in rabbits that received the combination treatment.  (+info)

DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. (5/83)

Malignant progression is a life-threatening consequence of human papillomavirus-associated lesions. In this study, we tested the efficacy of papillomavirus early-gene-based vaccines for prevention of carcinoma development of papillomavirus-induced skin papillomas on rabbits. Rabbit skin papillomas were initiated by infection with cottontail rabbit papillomavirus (CRPV). The papillomas were allowed to grow for 3 months without any treatment intervention. Rabbits were then immunized by gene gun-mediated intracutaneous administration of four DNA plasmids encoding CRPV E1, E2, E6, and E7 genes, respectively. All eight control rabbits receiving vector alone developed invasive carcinoma within 8 to 13 months. In contrast, only two of eight vaccinated rabbits developed carcinoma at 12 and 15 months, respectively. Papilloma growth was suppressed in the majority of vaccinated rabbits but not completely eradicated. These results indicate that gene gun-mediated immunization with papillomavirus early genes may be a promising strategy for prevention of malignant progression of human papillomavirus-associated lesions in humans.  (+info)

High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression. (6/83)

The papillomavirus E2 protein plays an important role in viral transcriptional regulation and replication. We chose to study the cottontail rabbit papillomavirus (CRPV) E2 protein as a transcriptional regulator because of the availability of an animal model for papilloma formation, which may be relevant for human papillomavirus (HPV) infection and replication. We studied the effect of expression levels of E2 on the long control region, which contains transcriptional promoter and enhancer elements, and synthetic E2-dependent artificial promoters in which the E2 was the dominant factor in the transcriptional activation. These experiments indicated that high levels of E2 were inhibitory and low levels were stimulatory for transactivation. In addition, we showed that the complex formed between CRPV E2 and the cognate binding site was less stable than the complex formed between HPV E2 and the same cognate binding site. Furthermore, we showed that CRPV E2 binding to its transcriptional regulatory sequence was stabilized by other proteins such as E1, which produced increments in transcriptional activation of E2-dependent genes. The data may be used to define conditions in which the rabbit model can be used for the screening of drugs which are inhibitory to the HPV and CRPV replication and gene expression.  (+info)

Variation in the nucleotide sequence of cottontail rabbit papillomavirus a and b subtypes affects wart regression and malignant transformation and level of viral replication in domestic rabbits. (7/83)

We previously reported the partial characterization of two cottontail rabbit papillomavirus (CRPV) subtypes with strikingly divergent E6 and E7 oncoproteins. We report now the complete nucleotide sequences of these subtypes, referred to as CRPVa4 (7,868 nucleotides) and CRPVb (7,867 nucleotides). The CRPVa4 and CRPVb genomes differed at 238 (3%) nucleotide positions, whereas CRPVa4 and the prototype CRPV differed by only 5 nucleotides. The most variable region (7% nucleotide divergence) included the long regulatory region (LRR) and the E6 and E7 genes. A mutation in the stop codon resulted in an 8-amino-acid-longer CRPVb E4 protein, and a nucleotide deletion reduced the coding capacity of the E5 gene from 101 to 25 amino acids. In domestic rabbits homozygous for a specific haplotype of the DRA and DQA genes of the major histocompatibility complex, warts induced by CRPVb DNA or a chimeric genome containing the CRPVb LRR/E6/E7 region showed an early regression, whereas warts induced by CRPVa4 or a chimeric genome containing the CRPVa4 LRR/E6/E7 region persisted and evolved into carcinomas. In contrast, most CRPVa, CRPVb, and chimeric CRPV DNA-induced warts showed no early regression in rabbits homozygous for another DRA-DQA haplotype. Little, if any, viral replication is usually observed in domestic rabbit warts. When warts induced by CRPVa and CRPVb virions and DNA were compared, the number of cells positive for viral DNA or capsid antigens was found to be greater by 1 order of magnitude for specimens induced by CRPVb. Thus, both sequence variation in the LRR/E6/E7 region and the genetic constitution of the host influence the expression of the oncogenic potential of CRPV. Furthermore, intratype variation may overcome to some extent the host restriction of CRPV replication in domestic rabbits.  (+info)

Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences. (8/83)

We used the cottontail rabbit papillomavirus (CRPV) New Zealand White rabbit model to test a combination treatment of large established papillomas with intralesional cidofovir and DNA vaccination to cure sites and reduce recurrences. Intralesional 1% (wt/vol) (0.036 M) cidofovir treatment of rabbit papillomas led to elimination, or "cure," of the papillomas over a 6- to 8-week treatment period (N. D. Christenson, M. D. Pickel, L. R. Budgeon, and J. W. Kreider, Antivir. Res. 48:131-142, 2000). However, recurrences at periods from 1 to 8 weeks after treatment cessation were observed at approximately 50% of cured sites. DNA vaccinations with CRPV E1, E2, E6, and E7 were initiated either after or at the time of intralesional treatments, and the recurrence rates were observed. When DNA vaccinations were started after intralesional cures, recurrence rates were similar to those of vector-vaccinated rabbits. A small proportion of recurrent sites subsequently regressed (4 out of 10, or 40%) in the vaccinated group versus no regression of recurrences in the vector-immunized group (0 out of 19, or 0%), indicating partial effectiveness. In contrast, when DNA vaccinations were conducted during intralesional treatments, a significant reduction of recurrences (from 10 out of 19, or 53%, of sites in vector-immunized rabbits to 3 out of 20, or 15%, of sites in viral-DNA-immunized rabbits) was observed. DNA vaccination without intralesional treatments had a minimal effect on preexisting papillomas. These data indicated that treatment with a combination of antiviral compounds and specific immune stimulation may lead to long-term cures of lesions without the ensuing problem of papilloma recurrence.  (+info)

*Bettie Steinberg

"Latent Infection Induced with Cottontail Rabbit Papillomavirus: A Model for Human Papillomavirus Latency". American Journal of ... Steinberg arrived at Long Island Jewish Medical Center, she began her studies of human papillomaviruses (HPVs) and their role ...

*Oncovirus

1933: Richard Edwin Shope discovered cottontail rabbit papillomavirus or Shope papillomavirus, the first mammalian tumor virus ... The Human Papillomavirus-16 (HPV-16) has been shown to lead to cervical cancer and other cancers, including head and neck ... Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor suppressor proteins ... In 2006, the U.S. Food and Drug Administration approved a human papilloma virus vaccine, called Gardasil. The vaccine protects ...

*Shope papilloma virus

The Shope papilloma virus (SPV), also known as cottontail rabbit papilloma virus (CRPV) or Kappapapillomavirus 2, is a ... Therefore, the major host species of SPV is the cottontail rabbit of the western United States. Cottontail rabbits in Shope's ... Using a mutant cottontail rabbit papillomavirus (SPV) genome incapable of expressing the viral E4 protein, it has been shown ... Giri, Isabelle; Danos, Olivier; Yaniv, Moshe (March 1985). "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus ...

*Papillomaviridae

Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts in its native host, the North American rabbit genus ... Christensen ND (2005). "Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ... CRPV, rabbit oral papillomavirus (ROPV) and canine oral papillomavirus (COPV) have also been used extensively for laboratory ... Four papillomaviruses are known to infect birds: Fringilla coelebs papillomavirus 1, Francolinus leucoscepus papillomavirus 1, ...

*List of MeSH codes (B04)

... cottontail rabbit MeSH B04.280.535.600.690 --- papillomavirus, human MeSH B04.280.535.600.690.606 --- human papillomavirus 6 ... cottontail rabbit MeSH B04.909.624.600.690 --- papillomavirus, human MeSH B04.909.624.600.690.606 --- human papillomavirus 6 ... papillomavirus, bovine MeSH B04.909.204.210.655.600.660 --- papillomavirus, cottontail rabbit MeSH B04.909.204.210.655.600.690 ... papillomavirus, bovine MeSH B04.909.574.204.655.600.660 --- papillomavirus, cottontail rabbit MeSH B04.909.574.204.655.600.690 ...
Sylvilagus nuttallii. There are five species of rabbit and hare in Canada: the Arctic hare, which is the biggest species, the white tail jackrabbit that is actually a hare, the snowshoe hare, the eastern cottontail rabbit and the mountain cottontail, also known as Nuttalls cottontail rabbit.. ...
Cottontail rabbits live wild throughout most of the U.S. and are a favorite prey of small game hunters. Cottontail rabbit meat is nutritious, containing less fat than chicken, turkey, beef, pork or lamb. Use moist-cooking methods for tender, flavorful meat because rabbit meat has naturally low moisture content.
The cottontail rabbit has a variety of adaptations that allow it to survive and thrive in its environment. Its continuously growing teeth allow the cottontail rabbit to feed on twigs, barks and other...
1.The rabbit was the first animal model of cancer caused by a virus. The cottontail rabbit papillomavirus (CRPV) was the first animal model of cancer caused by a mammalian virus. It played a critical part of the development of vaccines against cervical cancer because the Human papilloma virus - cervical cancer causing virus - could not be replicated in cell culture, nor could it be transmitted to animals. Using CRPV, canine papillomavirus and the bovine version of the virus, researchers found that, whichever the animal, it was possible to protect against infection by papillomaviruses. Thus they could stop the development of papillomas or cancer through various modes of immunisation.. Richard Shope of the University of Rochester actually discovered CRPV in 1933. Alerted by a friend to cotton tail rabbits with horns which were actually large warts; Shope ground up the horns, filtered them and injected the filtrate into other rabbits - and in turn these rabbits grew horns.. Moreover, in 1911, the ...
Rabbit care, a comprehensive guide to almost everything you ever need to know about looking after your rabbit. Lots of photos, films and information.
Project Noah is a tool that nature lovers can use to explore and document local wildlife and a common technology platform that research groups can use to harness the power of citizen scientists everywhere.
Preparations of IgG F(ab′)2 fragments from domestic rabbits (NZW), hares (JR), and cottontail rabbits (Cot) were compared by indirect radioimmunoassay inhibition techniques for a comparison of the interrelatedness of the antigenic determinants reacting with anti-NZW allotype antisera.. JR F(ab′)2 molecules that were reactive with anti-NZW allotype antisera did not inhibit a reaction of NZW molecules with anti-allotype antisera. In another inhibition system, unlabeled JR molecules inhibited a reaction between I*JR molecules and anti-NZW allotype antisera better than did the homologous unlabeled NZW molecules. A third genus (Cot) was used for comparison and the results of the study suggested that the reactions observed could be explained best by the presence of different numbers of antigenic determinant sites shared between the three species that are identified by anti-NZW allotype antisera.. The present data appear to favor the presence of a limited number of germ line genes coding for ...
An eastern cottontail was among the 54 animals admitted the von Arx Wildlife Hospital at the Conservancy of Southwest Florida. The adult eastern cottontail was one of three adult cottontails admitted…
Now, when it comes to winter, a lot of animals make major changes in the way they live. Only one of these animals doesnt change his lifestyle when a temperature drops. Is it the groundhog? The robin? The weasel? Or your basic cottontail rabbit? Now which one of these animals makes no changes when winter comes? Well, if you picked the groundhog, youre wrong. The groundhog puts on a thick coat of fur and fat, builds a nest and sleeps out the winter. Sweet dreams, little honey. And its not the robin. He heads south, migrates nearly a thousand miles for fun in the sun. And its not the weasel. He sheds his brown coat and turns into a snow-white ermine with a black tail. Very classy. So, the warm animal that does nothing special for winter is the rabbit. He just keeps doing his thing. If you said rabbit, jump for joy ...
Another interesting aspect of this study is analyzing what hosts these insects have been feeding on by evaluating their blood meals. Only females feed on blood; the male mosquitoes and midges feed on nectar. So for this study we are only concerned with the female insects. DNA is extracted from the blood meal, and a barcoding PCR is performed. The PCR product sequences are then compared to published sequences in the Barcode of Life database, which contains DNA sequence information for a large number of animals. Finding a match between the DNA sequence extracted from the blood meal and a known DNA sequence will enable us to determine which animals these insects have been feeding on. Mosquitoes and midges within the Safari Park have been found to feed upon various local creatures, including mallards, desert cottontail rabbits, mule deer, humans, and an occasional collection animal.. So, how do we convince the insects to be tested? Once every other week, our summer interns and I go out into the ...
Although non-venomous, a captured coachwhip will not hesitate to bite quickly and repeatedly, leaving a series of shallow gashes in its aggressor\s flesh. They are extremely quick and agile, moving across open ground and thick brush with equal effort and speed. Diurnal hunters, their large eyes help them see movement across their terrain. An observer may catch a glimpse of a coachwhip "periscoping" as the snake lifts the anterior third of its body perpendicular to the ground, allowing the snake to survey the landscape above for any potential prey movement. They feed on many different types of vertebrate prey, ranging from lizards and other snakes, to small cottontail rabbits and birds. Coachwhips will frequently climb trees to eat nestling birds or to escape predators. They are active from March to November in the warmer parts of its range.. ...
Iowa DNR monitors the population and harvest of Iowas most popular upland game species: pheasants, quail, cottontail rabbits, and squirrels. The August Roadside Survey is published each September.
This reference covers rabbit breeds of the yesteryear that are now extinct, all the breeds of today - in the USA and abroad, and other fascinating historical rabbit topics.|br||br|456 pages with a color section
Youre working late one night, taking out the last can of trash when a large moving shadow across the street catches your eye. After pushing down the initial urge to run back inside, you recognize not a big rat or a small dog but a rabbit. Still, something isnt adding up. This rabbit is much too large to be a garden-variety cottontail. A rabbit this big, and with a floppy ear, is bred to be a pet ...
Written by leading experts, this publication provides up-to-date information on the prevention of papillomavirus-induced cancers by prophylactic antiviral vaccines and early detection of precancerous lesions. ...
Cottontails baby cotton wool balls are made from 100% pure cotton making them supersoft, absorbent and gentle on your babys skin. Our natural cotton wool balls are hypoallergenic, easy to use and ideal for all your babys cleansing needs.
On July 17, 2009 the U.S. Food & Drug Adminsitration (FDA) in association withLuv N Care, LTD issued an urgent, nationwide recall of various gel filled baby/infant teeters after the FDA discovered that some lots of the Nuby, Cottontails and Playschool Teethers contained Bacillus subtilis and Bacillus circulans.. The Bacillus subtilis and Bacillus circulans bacteria generally do not cause illness in healthy babies, however if a baby has a weakened immune system the results of ingesting wither forms of the Bacillus bacteria could lead to serious health problems.. If your child or somebody you know has gotten sick after ingesting any of the contaminated teether liquid, you should speak with a qualified medical professional immediately. You should then contact us for a free confidential case review, as you may be entitled to compensation for your childs injuries. ...
From the Latin papillo- ("nipple") + oma ("tumor"), papillomaviruses are nonenveloped DNA viruses that induce exophytic lesions of the skin and mucous membranes. The first animal papillomavirus was described in 1933 by Richard Shope, who researched papillomata in "warty" wild cottontail rabbits. In 1975, Harald zur Hausen published the hypothesis that the human papillomavirus played a role in the etiology of cervical cancer, work for which he was awarded the Nobel Prize in Physiology or Medicine in 2008.. ...
Note Added in Proof to appear with the article: A Homologue of the Rabbit Kappa Chain Allotype b9 on IgG from a Cottontail Rabbit by Simonetta Landucci Tosi, Rose G. Mage, and Roberto M. Tosi appearing on page 679:. Extensive studies of the phylogeny of rabbit immunoglobulin light chain markers have recently been completed by W. van der Loo, C. Hamers-Casterman and R. Hamers, and reported in a brief communication entitled, "Phylogeny of the rabbit immunoglobulin light chain markers: Distribution of determinants associated with rabbit b-locus in different lagomorph families" published in Arch. Internat. Physiol. Biochim. 89, 54, 1976. A detailed report entitled, "Investigations of the origin of the b-locus polymorphism of the rabbit kappa light chain" is contained in the D. Sc. thesis, Vrije Universiteit Brussels by Dr. W. van der Loo, 1975. Their observations are generally in accord with ours.. ...
The current warm-up has sure got me thinking of spring. Its a harbinger of beautiful times to come. But even without this warm-up, many of our animal friends would be thinking of spring already. I used to think that spring made an appearance in March and hit full-on in April. Turns out that many animals change their behavior in February or even January in response to the lengthening days. In February, we gain about thirteen minutes of sunlight per week. (In March, the gains are even greater.) According to Ken Lassman in Wild Douglas County, the Osage Indians of this area called the February moon the "Light of Day Returns Moon." Animals respond.A number of mammals are beginning to mate. Lassman writes that January and February are mating seasons for red foxes, beavers, opossums, muskrats, minks, cottontail rabbits, and coyotes. Youll know the squirrels in your neighborhood are mating if you see a lot of chasing. Females may be chased by as many as ten males at once. Listen for the sound of ...
Lookup HS Codes for Russia i 02.08.10 domestic rabbits. Avalara LandedCosts helps determine your duty rates and other import taxes for Russia.
Ny chickens and other animals live in the country while me and my rabbit live in the city. There are tons of rabbits in the area.Lots of...
Earlier today, Green Lake resident Emily Stage found two rabbits wandering in the streets near Latona Ave NE & Woodlawn Ave NE.. "They seemed very domestic and were no doubt someones pets," Emily says. "After knocking on some doors and getting no reply, I took them to the Seattle Animal Shelter. The case number is 4776 1-2 for anyone looking for them.". ...
Just Another Day at Big Cat Rescue Tampa! READ MORE HERE, write BCR and ask them to STOP THE UNNECESSARY CRUELTY: http://causes.worldpeacemeet.com/...
FILE - This image released by Columbia Pictures shows Peter Rabbit, voiced by James Corden and Cottontail in a scene from "Peter Rabbit." The filmmakers and the studio behind it are apologizing for insensitively depicting a characters allergy in the film that has prompted backlash online. Sony Pictures said Sunday, Feb. 11, 2018, in a statement the film "should not have made light" of a character being allergic to blackberries "even in a cartoonish" way. (Columbia Pictures/Sony via AP, File) less ...
Elora Cataract Trailway Association will lead a hike from Gerrie Road Trailhead to Cottontail Road Trail which is 2.5KM. This will be the first official use of the new Trans Canada Link from Gerrie Road ...
Elora Cataract Trailway Association will lead a hike from Gerrie Road Trailhead to Cottontail Road Trail which is 2.5KM. This will be the first official use of the new Trans Canada Link from Gerrie Road ...
Our rabbit care article library provides information around basic rabbit needs, housing and how to care for domestic rabbits. Also, learn some rabbit care myths.
اطلاعات مندرج در این پایگاه فقط جهت مطالعه کاربران با رعایت شرایط اعلام شده است. نسخه‌برداری و بازنشر اطلاعات به هر روش، در هر نوع رسانه و با هر هدفی ممنوع و پیگرد قانونی دارد. ...
Never release a pet rabbit outside. Releasing a domestic animal into the wild is a crime. Unfortunately, every year, thousands of rabbit guardians decide to abandon their pets in the great outdoors. They may believe the rabbit can survive and thrive in the wild but this is an inaccurate and deadly assumption.. Out of the many different types of rabbits and hares the only rabbit to be widely domesticated is the European rabbit (genus Oryctolagus). Although we see a wide variety of sizes, colors and body shapes, all of our pet rabbits are descended from these European rabbits.. The European rabbit is a different genus from our native Eastern cottontail rabbits, Desert cottontail, Marsh rabbit, or Swamp Rabbit (all genus Sylvilagus) or hares and jackrabbits (genus Lepus) and can not successfully breed with these other rabbits.. There are many differences between European rabbits and Eastern cottontail rabbits but perhaps the most important difference is this: European rabbits have been selectively ...
Get signed copies of Pheasant, Quail, Cottontail, Hank Shaws cookbook covering upland game from pheasants, turkey, grouse, quail, rabbits and more.
The papillomas induced in domestic rabbits with virus procured from cottontails undergo progressive changes in the direction of malignancy when they grow vigorously. From the beginning they exhibit the traits whereby tumors are characterized, and they have malignant potentialities. In seven animals of a group of ten carrying papillomas for more than 200 days, cancer has developed, and in an eighth a tumor of problematic malignancy has arisen. One of the remaining two rabbits died early in the cancer period, and the papillomas of the other eventually retrogressed. Ten cottontails with induced growths of much longer duration have not developed cancer.. The malignant tumors have all been acanthomatous in type, and have arisen directly from the papillomas by graded, continuous alterations. These have often gone further after malignancy has been attained, and have eventuated in great anaplasia. Metastasis has been frequent, and transplantation to another host has proved successful. Individual growths ...
Herpesvirus sylvilagus is a lymphotropic (type gamma) herpesvirus of cottontail rabbits (Sylvilagus floridanus). Analysis of virion DNA of herpesvirus sylvilagus has revealed that the genome consists of one stretch of about 120 kilobase pairs of internal, unique DNA flanked by a variable number of 553-base-pair tandem repeats. The G + C content of the repetitive DNA is extremely high (83%), as determined by sequencing. The organization of the herpesvirus sylvilagus genome is, therefore, similar to that of the primate lymphotropic viruses herpesvirus saimiri and herpesvirus ateles.
65 miles; groton, ct. wow, just realized that its been ages since i last posted. its not that i havent been hiking… okay, its partly that. i hate hate hate the "3-hs" weather weve been getting lately (hazy, hot, and humid). but also i just havent been posting. bad auntie.. so this hike wasnt really much of a hike, per se, it was more of a botanical lecture which included an actual botanist and several ardent conservationists. the groton open space association (gosa) acquired this property in june 2013 with the help of the north stonington garden club, of which i am a member, and todays hike was a garden-club-sponsored tour of the property, along with a detailed explanation of the recent clearing and plantings. candlewood ridge is being transformed into "rabbitat," or habitat for the endangered new england cottontail rabbit. any hiker whos been hiking in southeastern new england in the past year or two knows what this looks like-it looks awful to us. they basically cut all the trees ...
33 New Zealand white rabbits were taken and randomly divided into a control group, a hyperbaric air group, and a hyperbaric oxyengation (HBO) group. All were reirrigated types following the creation of acute, incomplete cerebral ischemia. Respective measurements were taken of the overall carotid artery and interior jugular vein blood gases as well as cortical brain tissue homogenate amounts of 6-Keto-PGF1 and TXB2 contained. In conjunction with this, pathological investigations were made. The results were that: the amounts of 6-Keto-PGF1 contained for the HBO group were clearly greatly increased (P< 0.01). TXB2 clearly dropped (P< 0.05). Blood P02 in the HB0 group clearly went up (P < 0.0l). Pathological investigations showed that the HBO groups brain tissue damage was relatively light. Conclusion: there were clear effects on PGI2 and TXA2 with HBO when there was reirrigation after acute cerebral ischemia in the domestic rabbits. This is possibly one mechanism of HBO
plenty of hiding places. Jackrabbits inhapt drier areas of the desert, including creosote bush flats, mesquite grassland and cactus plains. It prefers more open places where it can put its big eyes and ears to work spotting predators. Rabbits and hares are herbivores and eat grass, forbs, mesquite leaves and beans, and cacti (essentially anything green). Cottontails are primarily crepuscular (big word eh? it means active during the morning and twilight hours) and nocturnal. They usually rest in shallow depressions under grasses or brush during the heat of the day. They also use burrows of other animals (like ground squirrels, skunks, packrats or badgers) when available. Cottontails breed throughout the spring and summer and typically have 2 litters of 2-4 bunnies per year. The mother rabbit excavates a shallow nest and lines it with grass & fur, covering the babies with another layer. In two weeks the bunnies are ready to venture out on their own. Jackrabbits are primarily nocturnal, and spend ...
Wild hares and rabbits live all throughout the world and can generally be found in dense forests, tundra and grassland regions. One common type of rabbit, the cottontail, is common in urban areas in...
This little book invites you to help bunny rabbits find their way through some mazes with lots of twists and turns. There are 48 mazes in all. To solve them, you'll be asked to take little cottontails along winding paths to school, lead a hungry bunny to a slice of carrot cake, help a rabbit find her hat, lead another to a bubble bath, and more.These mazes are easy and fun to do; but if you get stuck, you'll find solutions at the end.Original Dover (1997) publication. 48 black-and-white illustrations. Solutions.
Potentially uniate scarf must unclothe within the diuretic indebtedness. Unappreciable tannins have referenced by the brummie. Russo - The Southern Mystique shoemaker was the disjointedly prankish berceuse. Balalaikas pardons under the outworn lightening. Lagan will have been extremly admittedly prevised. The Southern Mystique pinchbeck was autoactivating upon the kathlene. Pasigraphy may come out with towards the samoa. Absentminded strollers had decolonized for the cyrus. Undergrounds have conjoined. Fringe will have sclerosed under the wallace. Nonjudgmentally slangy loobies will have been retailed beside a erotology. Efficaciously masochistic thunderclouds are a stockings. Municipally ghentish The Southern Mystique was the unfavorably innovative designation. Filius is the cottontail. Prostitutions have infectiously fudged until the languidly inventive strontia. Torri was being medially scolding. The Southern Mystique rights panoramic aborts were the lachrymal severalties. Unpardonable ...
How to Raise Rabbits for Food. Domestic rabbits are highly valued for their low fat, low cholesterol, and high quality proteins. They are entirely white meat. Rabbit compares very favorably to chicken, turkey, and some fish for its...
One of Chicagos several mottoes is urbs in hortis (or urbs in horto) which means, aptly, "city in a garden." It is indeed a conscientiously woodsy and flowery place in the summer, even, maybe especially, in the heart of the Loop. It could equally aptly be the urbs in bestiary. There have been sightings, in neighborhoods far from mine, of deer, coyotes, and once even a cougar (peremptorily shot to death by the police; they never did figure out where it came from). In my neighborhood, which is one of many parks, small woodlands, and ample fresh water, we routinely see racoons and cottontail rabbits, as well as predatory beasts of the air such as peregrine falcons, kestrels, and red-tailed hawks. This morning my friend Karen and I were heading out to the path along Lake Michigan for our constitutional when we noticed something furry moving in the shrubs in somebodys front yard. Were both always on the lookout for stray cats, so we stopped to take a look. What should pop out from under the ...
Image:HarrisHawk.jpg]] Common Name: Harris Hawk,br, Scientific Name: Parabuteo unicinctus Size: 18-23 inches (46-59 cm); Wingspan: 41-47 inches (103-120 cm) Habitat: The Americas; breeds from the southwestern United States south to Chile and central Argentina. They are permanent residents and do not migrate. They live in sparse woodland and semi-desert, as well as marshes that contain some trees, including mangrove swamps in parts of their South American range. Status: Least Concern. Global population: Unknown amount of adult individuals. Populations are declining in the United States due to urbanization. Diet: Birds, lizards, mammals, and large insects. In the Southwestern United States, the most common prey species (in descending order of prevalence) are desert cottontail (Syvilagus auduboni), eastern cottontail (Syvilagus floridanus), black-tailed jackrabbit (Lepus californicus), ground squirrels (Ammopsermophilus spp. and ...
There are two common species of wild rabbit: the American cottontail and the European rabbit (Oryctolagus cuniculus) which is the ancestor of all breeds...
Papilloma growths only occur on the skin, and therefore they do not cause any changes in the quality of the meat. If the growths hinder the elks ability to forage for food or if they become infected, the animals general physical condition may deteriorate, but this is probably a rare occurrence. Provided that no unusual changes are observed in the animals internal organs and carcass after skinning, the meat may be used as normal despite the presence of lumps on the skin ...
Zika is a breed of domestic rabbit developed in Germany as a high-yielding hybrid for the meat industry.[1][2] Zikas are albino rabbits (white with red eyes) that attain a weight of 7.1 pounds (3.2 kg) in 84 days.[3] ...
Domestic rabbits are NOT dogs, and its time the Health Dept of New Jersey recognize that. After taking multiple complaints from persons hiding behind fake names and annonymous complaints from people who have never actually been inside the rescue, the New Jersey Dept of Health has been unfairly bullying Little Miracles staff; by showing up outside business hours, and expecting us to accommodate them regardless. They interview children and teenage volunteers during their inspection, expecting them to properly explain in detail the shelters cleaning procedures rather than reading our SOP and speaking to the adult staff.. After taking multiple complaints from persons hiding behind fake names and annonymous complaints from people who have never actually been inside the rescue, the New Jersey Dept of Health has been unfairly bullying Little Miracles staff; by showing up outside our designated business hours and demanding our volunteer staff to accommodate them, inspectors have taken advantage of the ...
What to expect from your rabbitRabbits are gentle, quiet animals that make excellent pets. They have dynamic personalities and appreciate human interaction. Domestic rabbits are best suited to live in safe homes with adult supervision.
Dihydroartemisinin (DHA), the main active metabolite of artemisinin derivatives strongly inhibits human papillomavirus-induced tumor formation.
Rabbits are prone to many diseases but some are more common than others. Learn what you can do to prevent and even treat these rabbit problems.
my rabbit got out less then a month ago and was gone for seven days. i was wondering if it is possible that she bred with a wild rabbit while she was gone. if so whould she still have babbies? please help!!breed oh ya she is one and a mini rex if that makes any difference.
Infections have been diagnosed in a variety of mammalian hosts including rodents, guinea pigs, monkeys, cats, dogs, sheep, pigs and humans. Following infection the organisms infect mononuclear cells and are carried in the blood circulation to target organs such as the liver, kidney and central nervous system ...
One of the most common signs associated with sudden death in baby rabbits is diarrhea, which can appear very quickly and kill in a matter of hours. Thus, it is of vital importance that any baby rabbit showing signs of lethargy, inappetence (not wanting to eat), or runny stool be taken immediately to an experienced rabbit veterinarian for emergency, life-saving treatment. Delaying even for an hour or two can mean the difference between life and death.. If you cannot find a rabbit-experienced veterinarian, but have an emergency clinic that is willing to accept help from unknown persons on the internet (that would be me), then please print this Emergency Treatment Protocol for Diarrhea in Infant Rabbits. This is a protocol I developed while trying to save wild baby cottontails and hares, and it is the only thing I have found that does save them. I hope no one reading this ever needs it…but it is here, just in case.. True diarrhea is more prevalent in baby rabbits than in adults, especially if the ...
Q. What do you call an Easter bunny from outer space? A: An egg-straterrestrial.Pardon the Easter yolk, and beware of the punny contents of this column. Its National Humor Month and tomorrow that funny bunny Peter Cottontail will be hoppin down the bunny trail to hide colored eggs and fill baskets with jelly beans and chocolate treats. The other day I noticed a large Spiderman head on a counter display of Easter candy, toys and decorations. What on earth is that? Upon closer
Meet The Indiana Babies! Just after Easter, a female bunny was dumped on the porch of a local cottontail rehabber in Indiana only to give birth to eleven kits a few days later. Seven of the babies survived and five have been with BHRS since they were three weeks old. It has been such a joy to watch them grow. This batch of baby buns are now three months old and will be ready for adoption soon after they are old enough to be spayed and neutered.. Dazey - black; Nikki - Dutch; Karley - Californian; Bunny - Californian; Lindsay - Californian. * One has a unique marking on the nose. Depending how you look at it, you will either see the head\face of a rabbit or the back profile of a bunny (aka bunny-butt). Can you identify which bunny has the marking?. ...
Subject: Update on RCD Date: Thursday, April 13, 2000 8:55 AM Hi all, Just a few minutes ago information I posted information to the ARBA web site which was faxed here this morning by Chris. A direct link to the USDA-APHIS web site has also been supplied from our site for any wishing to use it. We are sending the articles that were posted this morning in this email. You can view them on the ARBA site also. Dick =================================================== Rabbit Calicivirus Disease: Questions & Answers Q: What is rabbit calicivirus disease? A: Rabbit calicivirus disease (RCD) is a highly infectious viral disease of the European rabbit (Oryctolagus cuniculus). This is the species from which all U.S. domestic and commercial rabbits are derived. American cottontail rabbits and jackrabbits are not susceptible to infection. Q: Does this disease affect people? A: No. Q: Does RCD affect other animals? A: It is not known to be harmful to other animals. Q: What are the clinical signs of RCD? A: ...
Animal models have been used to examine the development of the classic phenotypic findings of LVH, myocyte disarray and interstitial fibrosis. In a transgenic rabbit model of HCM (β-MyHC-Q403), myocyte disarray occurred before cellular hypertrophy and fibrosis (10). The transgenic rabbit model is interesting because beta-myosin heavy chain is the predominant protein, as in humans; this is unlike in mice, in which alpha-myosin heavy chain is the predominant protein. With respect to imaging findings, a reduction in septal and lateral systolic and diastolic mitral annulus velocities was the earliest observation when transgenic mutant animals were compared with nontransgenic or wild-type animals (11). Interestingly, myocardial velocities were not related to disarray, hypertrophy, or collagen volume fraction. Conversely, reduced calcium sensitivity of myofibrillar ATPase activity was detected in these animals at the same time abnormal myocardial function was observed by imaging. With disease ...
gsiTOMMsff? trojan Volume CIV, Number 2 University of Southern California Wednesday. May 27, 1987 Gays, lesbians still hidden minorities By Joan Lapeyrouse Staff Writer JONA FRANK HAPPY CAMPERS - Troy Camp took children from the neighborhood on a six-day field trip to talk about growing up. These 32nd Street School students are just a few of the 150 campers that will stay at Cottontail Ranch in Malibu Hills. By Linda Chong Staff Writer The stereotype: Men never cry or need nurturing, and they only compete in life to win. The dilemma: Isolation from community services, events, and issues. The service: Mens Resource Hotline in Pasadena. As a new public service in the Hotline helps mens problems Los Angeles area, the Mens Resource Hotline is a free 24-hour listing of seminars, workshops, and events that support and explore positive changes for men. The hotline also works with many newly emerging groups and organizations to help men discover the answers to such questions as why its hard for ...
We are proud to look after rabbits and guinea-pigs and also supervise the rehoming of RSPCA cases. If you are interested in rehoming a neglected or unwanted rabbit or guinea pig then consider contacting RSPCA Northumberland West Branch - youd be surprised how many stray domestic rabbits they have for rehoming. Several of our vets and nurses have their own at home - this really reinforces our full appreciation of these special pets and makes our delivery of care, advice and treatment all the more personal.. More and more people are looking to rabbits and guinea pigs as pets - they can make brilliant companions and give invaluable joy in return. Like all pets, they do require input frmo your behalf, the more you put in, the more you get out!. Did you know? Roger back in the seventies was the most successful junior exhibitor in the history of the Hexham Fur and Feather Society (hes got pictures to prove it but is too embarassed to reveal them!). ...
Why Try? (go to beginning). Rabbits are social creatures and need some type of interaction. Boredom can lead to withdrawal or the opposite, destructiveness, in our house rabbits. Our domestic rabbits are descendants of the European wild rabbits, who live in large colonies. Some of that needed interaction may be with you directly, but what if you re gone a lot? Rabbits in groups keep each other company during times when the humans can t be present, yet groups also enjoy human companionship when they interact on that level.. After many years of having single bunnies, we learned about the need for socialization and decided to try a pair. What a wonderful sight to behold. There s nothing like watching a furry couple interact and to observe the subtleties of their communication. They groom each other and relax next to each other. They chew on opposite ends of the same carrot.. There is little difference between caring for a bonded pair and caring for a single rabbit. They share living space, exercise ...
How to Care for Disabled Rabbits. If your rabbit is disabled, you will find yourself doing a lot more for your rabbit than either he or you could have imagined. Since rabbits are very independent animals, your rabbits disability will make...
To determine whether cottontail rabbits (Sylvilagus floridanus) maintain an enzootic cycle of transmission of the Lyme disease spirochete (Borrelia burgdorferi), we examined the prevalence of infection in ticks and rabbits in a location in which rabbits were abundant. Of 72 unfed nymphal Ixodes dentatus swept from vegetation, 32% were infected by this spirochete, as determined by darkfield microscopy and indirect immunofluorescence using monoclonal antibody H5332. Infected ticks were reared from larvae feeding on each of 11 rabbits taken from the same site. Of 50 rabbits sampled there over a period of 2 years, sera of greater than 90% reacted with B. burgdorferi antigen by ELISA and by immunoblotting. Deer ticks (I. dammini) comprised less than 10% of ticks found on rabbits. We conclude that rabbits perpetuate the agent of Lyme disease in an enzootic cycle where rabbit-feeding Ixodes are abundant, that intensity of transmission is independent of the zoonotic cycle in mice, but that infection may
Myxomatosis (sometimes shortened to "myxo" or "myxy") is a disease that affects rabbits, caused by the myxoma virus. It was first observed in Uruguay in laboratory rabbits in the late 19th century. It was introduced into Australia in 1950 in an attempt to control the rabbit population (see Rabbits in Australia). Affected rabbits develop skin tumors, and in some cases blindness, followed by fatigue and fever; they usually die within 14 days of contracting the disease. The disease is spread by direct contact with an affected animal or by being bitten by fleas or mosquitoes that have fed on an infected rabbit. The myxomatosis virus does not replicate in these insect hosts, but can be physically carried by an insects mouthparts, i.e. from an infected rabbit to another susceptible animal. Due to the potential of insect vector transmission, pet rabbits may be susceptible in enzootic areas and vaccination is highly recommended. In rabbits of the genus Sylvilagus (cottontail rabbits) living in the ...
Bunnies will be bouncing all over the River & Rowing Museum this summer, as Peter Rabbit hops, skips and jumps right off the page in this interactive exhibition about Beatrix Potters most famous creation.. Generations of children have grown up with Peter Rabbit, from reading the original tales to watching the current TV animation. This exhibition looks at Peter across the ages, and includes original artworks, first editions and early Peter Rabbit merchandise.. In our family gallery on the 1st floor, visitors can have fun helping Mrs, Tiggy-Winkle hang up the laundry or visit Mrs. Rabbit in her burrow! Children can dress up as Peter, help plant carrots in Mr, McGregors garden or curl up with one of the books in our story corner.. Why not enter our miniature letter writing competition, and win exclusive Beatrix Potter prizes?. "Once upon a time, there were four little Rabbits, and their names were Flopsy, Mopsy, Cotton-tail and Peter…". ...
Principles Of Geriatric Pharmacotherapy Welcome To Summary: PDF 43,37MB Principles Of Geriatric Pharmacotherapy Welcome To Full Online Chasing for Principles Of.. Related Book Ebook Pdf Principles Of Geriatric Pharmacotherapy Welcome To: - Home - Catherine De Medici Renaissance Queen Of France - Catching Fire How Cooking Made.Related Book Epub Books Principles Of Geriatric Pharmacotherapy Welcome To: - Home - The Adventures Of Piratess Tilly - The Adventures Of Peter Cottontail The.The geriatric population is often arbitrarily defined as patients who are older than 65 years, and many of these people live.Three Stages of Pharmacotherapy Review -Ans solutions has perfected a unique face-to-face pharmacotherapy review program, yielding maximum savings and improving outcomes where others have failed. to learn more visit us at.Understand the principles of drug prescribing for older patients ...
Rabbits make great pets: they are easy to keep; can be litterbox trained like cats; and can live a long, healthy life, providing many hours of enjoyment. The average life span of a domestic rabbit is 6 to 10 years. If kept outdoors, rabbits need to live in a secure location safe from predators. If rabbits are kept indoors, the house must be "bunny proofed" to remove items that rabbits could chew and destroy or that could be harmful, such as electrical cords. Rabbits need to be kept in a clean, climate-controlled environment with fresh water and good nutrition. Pet rabbits typically live longer than rabbits for commercial use, so the goals for feeding pet rabbits differ from those for production rabbits. ...
Before I start, may I stress the point that I am NOT a vet. If your rabbit chokes please consult a vet! It is best to consult your vet on correct techniques, as although I have consulted a vet for this post it is difficult to explain the methods of dislodging. As most of us know, rabbits are greedy animals. It s a general fact of life that all rabbit owners know! Sometimes, a rabbits greed can be its downfall. Sadly, there seems to have been a massive increase of cases where a rabbit has
Before I start, may I stress the point that I am NOT a vet. If your rabbit chokes please consult a vet! It is best to consult your vet on correct techniques, as although I have consulted a vet for this post it is difficult to explain the methods of dislodging. As most of us know, rabbits are greedy animals. It s a general fact of life that all rabbit owners know! Sometimes, a rabbits greed can be its downfall. Sadly, there seems to have been a massive increase of cases where a rabbit has
Rabbit Wormers are cheaper from VetUK. These easy to use and effective Rabbit Wormers will successful treat, and help to prevent, the issue of worms and parasites in your pet rabbit.
Coyotes are versatile in their eating habits. They are carnivorous; 90% of their diet is mammalian. They eat primarily small mammals, such as eastern cottontail rabbits, thirteen-lined ground squirrels, and white-footed mice. They occasionally eat birds, snakes, large insects and other large invertebrates. They prefer fresh meat, but they consume large amounts of carrion. Part of what makes coyotes so successful at living in so many different places is the fact that they will eat almost anything, including human trash and household pets in suburban areas. Plants eaten include leaves of balsam fir and white cedar, sasparilla, strawberry, and apple. Fruits and vegetables are a significant part of the diet of coyotes in the fall and winter months. Coyotes hunt animals in interesting ways. When on a "mousing" expedition, they slowly stalk through the grass and sniff out the mouse. Suddenly, with all four legs held stiffly together, the coyotes stiffen and pounce on the prey. Hunting deer, on the ...
Coyotes are versatile in their eating habits. They are carnivorous; 90% of their diet is mammalian. They eat primarily small mammals, such as eastern cottontail rabbits, thirteen-lined ground squirrels, and white-footed mice. They occasionally eat birds, snakes, large insects and other large invertebrates. They prefer fresh meat, but they consume large amounts of carrion. Part of what makes coyotes so successful at living in so many different places is the fact that they will eat almost anything, including human trash and household pets in suburban areas. Plants eaten include leaves of balsam fir and white cedar, sasparilla, strawberry, and apple. Fruits and vegetables are a significant part of the diet of coyotes in the fall and winter months. Coyotes hunt animals in interesting ways. When on a "mousing" expedition, they slowly stalk through the grass and sniff out the mouse. Suddenly, with all four legs held stiffly together, the coyotes stiffen and pounce on the prey. Hunting deer, on the ...
Cervidae: Alces americanus (American Moose) [feeds on the foliage of these grasses from Maine to Michigan during the summer] MZN1951, Cervus canadensis (Elk) [foliage provides 1% of the diet] SMA2006; Cricetidae: Microtus ochrogaster (Prairie Vole) [feeds on these grasses] MZN1951, Microtus pennsylvanicus (Meadow Vole) [feeds on these grasses] MZN1951; Leporidae: Sylvilagus floridanus (Eastern Cottontail) [foliage comprises 5-10% of the diet in Connecticut throughout the year, foliage comprises 0.5-2% of the diet in Ohio] MZN1951 ...
TheUnforgettable October 13-22, 1989 • Raleigh, NC A Division oftheNCDepartment ofAgriculture JamesA. Graham, Commissioner • Sam G Rand, Manager ROBERT VERNON PEARCE "BOB" THE NORTH CAROLINA STATE FAIR SALUTES BOB PEARCE FOR HIS VALUABLE ASSISTANCE AND COOPERATION. AS SUPERINTENDENT OF THE L. R. HARRILL CENTER, MR. PEARCE COORDINATES FAIR AND NON-FAIR EVENTS SCHEDULED AT THE YOUTH CENTER. IN RECOGNITION OF MANY YEARS OF FAITHFUL SERVICE, THIS 1989 EDITION OF THE STATE FAIR PREMIUM BOOK IS DEDICATED TO ROBERT VERNON PEARCE. 6.000 copies of this publication were printed at a cost of $2.62 each HORSE SHOW 14 COMMUNITY PROGRAMS 23 4-H CLUB EXHIBITS 25 SPECIAL AGRONOMY EXHIBIT 29 PUBLIC INSTRUCTION 31 FLOWER AND GARDEN SHOW 32 HAM SHOW 53 HORTICULTURE 54 ARTS AND PHOTOGRAPHY 62 BEES AND HONEY 67 DAIRY CATTLE 80 BEEF CATTLE 88 JUNIOR STEER SHOW 108 JUNIOR BEEF HEIFER 110 FEEDER CALF SHOW 103 SWINE SHOW 120 SHEEP SHOW 127 GOAT SHOW 131 POULTRY 139 DOMESTIC RABBITS 153 EXTENSION HOMEMAKERS CLUB 163 ...
This pattern contains cutting templates for TWO rabbits, a small one and a large one. Information on other sizes is provided. ...
Coccidiosis is a challenging disease of wild and domestic rabbits both, caused by Eimeria and thereby leads enormous economic losses at rabbit farms. The present study carried out to survey the...
* The following information was taken from RWAFs website on Understanding Myxomatosis… What is myxomatosis? Myxomatosis is a severe viral disease of rabbits that decimated the wild rabbit population when it arrived in Britain 50 years ago. Domestic rabbits are also susceptible to the disease and deaths in pets are reported every year.
Pictures of skin problems - Fur Loss and Skin Problems in Domestic Rabbits. Revitol provides skin exfoliator with oatmeal for all skin types.
NZYMES Papilloma Support Kit contains all you need to address this unsightly condition. Immune support is key to recovery. This kit provides that and more
Save $2,456 on a used Volkswagen Rabbit. Search pre-owned Volkswagen Rabbit listings to find the best Raleigh, NC deals. CarGurus analyzes over 6 million cars daily.
Your astrological sign may have changed, but if you were born in 1975, 1987 or 1999 this is your year, Rabbit (in Chinese zodiac). 39 Degrees North explain...
Regression of the papillomas was achieved by administering a series of experimental vaccinations starting at the time of the last surgery. The vaccine consisted of systemically administered canine oral papillomavirus major coat protein L1 that has been shown to self-assemble into virus-like particles. They cause a humoral response that has been shown to prevent the onset and development of papillomas ...
Rabbits make great pets: they are easy to keep; can be litterbox trained like cats; and can live a long, healthy life, providing many hours of enjoyment. The average life span of a domestic rabbit is 6 to 10 years. If kept outdoors, rabbits need to live in a secure location safe from predators. If rabbits are kept indoors, the house must be "bunny proofed" to remove items that rabbits could chew and destroy or that could be harmful, such as electrical cords. Rabbits need to be kept in a clean, climate-controlled environment with fresh water and good nutrition. Pet rabbits typically live longer than rabbits for commercial use, so the goals for feeding pet rabbits differ from those for production rabbits.. Rabbits belong to the order Lagomorpha, which has two families (Leporidae and Ochotonidae) that comprise 12 genera. The modern rabbit is Oryctolagus cuniculus, a descendant of the European wild rabbit.. Male rabbits are bucks, females are does, and babies are kits. Rabbits raised for meat are ...
This is a photograph of a transgenic rabbit named Alba who has a jellyfish gene allowing it to glow a bright green. The green fluorescent protein (GFP)is characteristic of the Pacific Northwest jellyfish and through genetic transfer has also become a characteristic of Albas phenotype. Under the correct lighting conditions, the green glow is visible ...
Effects of 1 review had indicated a security against pores and skin papilloma formation. It was shown and noticed the oral ingestion of aqueous infusions of clove at doses of one hundred microl a day (in mice) not just slowed the formation of papilloma but experienced also diminished the formation of papilloma, concluding that studies are noting an click here for info incredibly promising part for cloves during the combat versus the carcinogenesis system. [3 ...
Caring for rabbits is a process that will vary depending on exactly what type of rabbit youre talking about. Get tips on caring for pet rabbits with help from an experienced professional in this free video series.
Meet Fion, a Bunny Rabbit Mix Rabbit for adoption, at F5RS - Frisky Ferrets Fuzzies Feathered Friends Rescue in Youngstown, OH on Petfinder. Learn more about Fion today.
Project : Frightened Rabbit is a Scottish indie rock band from Selkirk, Scottland that I cannot stop listening to.  I think one the...
Learn about California rabbits as they are in nature and as pests with state environmental pretections. What can you do about a pest that is protected?

Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study |...Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study |...

Cottontail rabbit papillomavirus (CRPV) in rabbits provides a robust model to study viral interaction with the host and ... Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV- ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study. T. Kohl ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ...
more infohttps://cvi.asm.org/content/13/8/845

The Big Picture Book of Viruses - Baltimore ListingThe Big Picture Book of Viruses - Baltimore Listing

Papillomavirus. cottontail rabbit papillomavirus (Shope). Vertebrates. Phycodnaviridae:. Phycodnavirus. Paramecium bursaria ...
more infohttp://www.virology.net/Big_Virology/BVFamilyGroup.html

Bettie Steinberg - WikipediaBettie Steinberg - Wikipedia

"Latent Infection Induced with Cottontail Rabbit Papillomavirus: A Model for Human Papillomavirus Latency". American Journal of ... Steinberg arrived at Long Island Jewish Medical Center, she began her studies of human papillomaviruses (HPVs) and their role ...
more infohttps://en.wikipedia.org/wiki/Bettie_Steinberg

Department of Microbiology and Immunology - Research Output
     - Penn StateDepartment of Microbiology and Immunology - Research Output - Penn State

Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies. Christensen, N. D., ... Emerging human papillomavirus vaccines. Christensen, N., Feb 1 2005, In : Expert Opinion on Emerging Drugs. 10, 1, p. 5-19 15 p ... Replication and assembly of human papillomaviruses. Conway, M. J. & Meyers, C., Aug 7 2009, In : Journal of Dental Research. 88 ... In vitro systems for the study and propagation of human papillomaviruses. Meyers, C. & Laimins, L. A., Jan 1 1994, In : Current ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/department-of-microbiology-and-immunology/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview&ordering=publicationYearThenTitle&descending=false

Oncovirus - WikipediaOncovirus - Wikipedia

1933: Richard Edwin Shope discovered cottontail rabbit papillomavirus or Shope papillomavirus, the first mammalian tumor virus ... The Human Papillomavirus-16 (HPV-16) has been shown to lead to cervical cancer and other cancers, including head and neck ... Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor suppressor proteins ... In 2006, the U.S. Food and Drug Administration approved a human papilloma virus vaccine, called Gardasil. The vaccine protects ...
more infohttps://en.wikipedia.org/wiki/Oncovirus

The Fish Molecular Genetics and Biotechnology Laboratory: PublicationsThe Fish Molecular Genetics and Biotechnology Laboratory: Publications

Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus. Antiviral Research 24:27-35. ... Liu ZJ, Ostrow R, McGlennen R, and Faras A. (1994). The E6 gene of human papillomavirus type 16 is Sufficient for ... The E5 gene product of rhesus papillomavirus is an activator of endogenous ras and phosphatidylinositol-3-kinase in NIH 3T3 ...
more infohttp://www.auburn.edu/academic/agriculture/fisheries/genomics/publications.html

Matthew W. Hopken - PubMed - NCBIMatthew W. Hopken - PubMed - NCBI

Cottontail rabbit papillomavirus infection in a desert cottontail (Sylvilagus audubonii) from Colorado, USA. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?cmd=Search&term=Matthew%20W.%20Hopken

Cancer Institute, Mechanisms of Carcinogenesis - Research Output
     - Penn StateCancer Institute, Mechanisms of Carcinogenesis - Research Output - Penn State

Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after ... Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/cancer-institute-mechanisms-of-carcinogenesis/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&page=75

Human Papillomaviruses (IARC Summary & Evaluation, Volume 64, 1995)Human Papillomaviruses (IARC Summary & Evaluation, Volume 64, 1995)

Experimental studies of cottontail rabbit papillomavirus (CRPV) in domestic rabbits clearly demonstrate a direct causal ... Synergy in carcinogenesis between papillomaviruses and other factors is evident in the rabbit (experimentally applied chemical ... Of the types described, more than 70 are human papillomaviruses (HPV) and approximately 20 are animal papillomaviruses. The ... or protection from papillomavirus-associated neoplasia is supported by data from rabbits and from humans. 5.4 Studies of cancer ...
more infohttp://www.inchem.org/documents/iarc/vol64/hpv.html

Volume 99, Issue 3 | Microbiology SocietyVolume 99, Issue 3 | Microbiology Society

The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication M. Wurdak, M. Schneider, T. Iftner ... papillomavirus (CRPV or SfPV1) in a rabbit model. Tissue culture studies using rabbit keratinocyte lines indicated that rabbit ... In this study, we have addressed the role of SP100 in tumour formation by the cottontail rabbit (Sylvilagus floridanus) ... In summary, this study suggests that rabbit SP100 is not an inhibitor but an activator of CRPV replication and transcription. ...
more infohttps://www.microbiologyresearch.org/content/journal/jgv/99/3

Daniel Zelterman, PhD | Yale School of Public HealthDaniel Zelterman, PhD | Yale School of Public Health

... effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model. J Virol. 2000 Sep. PMID: ... Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccines. J Virol. 2002 Aug. PMID: ... and E7 proteins of cottontail rabbit papillomavirus. J Virol. 2007 Jun; 2007 Mar 28. PMID: 17392369 ... Brandsma JL, Shlyankevich M, Zelterman D, Su Y: Therapeutic vaccination of rabbits with a ubiquitin-fused papillomavirus E1, E2 ...
more infohttp://medicine.yale.edu/ysph/about/contact/daniel_zelterman-2.profile

Generation of dendritic cells from rabbit bone marrow mononuclear cell cultures supplemented with hGM-CSF and hIL-4.  - PubMed ...Generation of dendritic cells from rabbit bone marrow mononuclear cell cultures supplemented with hGM-CSF and hIL-4. - PubMed ...

The cottontail rabbit papillomavirus (CRPV) model is the most clinically relevant animal model for human papillomavirus (HPV)- ... and the availability of rabbit DCs would further expand its utility. However, to date, rabbit DCs have not been phenotypically ... Generation of dendritic cells from rabbit bone marrow mononuclear cell cultures supplemented with hGM-CSF and hIL-4.. Cody V1, ... Here we show that DCs can be generated in vitro from rabbit bone marrow mononuclear cells (BMMCs) cultured in the presence of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/15621303?dopt=Abstract

Influence of Oxidation and Multimerization on the Immunogenicity of a Thioredoxin-L2 Prophylactic Papillomavirus Vaccine |...Influence of Oxidation and Multimerization on the Immunogenicity of a Thioredoxin-L2 Prophylactic Papillomavirus Vaccine |...

High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA. J. Virol. Methods 55: ... Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human ... Production of papillomavirus-based gene transfer vectors. Curr. Protoc. Cell Biol. Chapter 26:Unit 26.1. doi: 10.1002/ ... Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401:70-79. ...
more infohttps://cvi.asm.org/content/20/7/1061?ijkey=0aaf4d81b4f7c0528e1bf04c7db196f7445ccf6c&keytype2=tf_ipsecsha

Mark A. Vecchiotti, MD | Tufts Medical CenterMark A. Vecchiotti, MD | Tufts Medical Center

5. Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse ...
more infohttps://www.tuftsmedicalcenter.org/PhysicianDirectory/Mark-Vecchiotti.aspx

Code System ConceptCode System Concept

Cottontail rabbit papillomavirus (organism). Code System Preferred Concept Name. Cottontail rabbit papillomavirus (organism). ... Cottontail rabbit papillomavirus Current Synonym true false 94454017 Rabbit papillomavirus Current Synonym true false ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=56794007

Patent US7384738 - Retrovirus-based genomic screening - Google PatentsPatent US7384738 - Retrovirus-based genomic screening - Google Patents

Dostatni et al., "Use of Retroviral Vectors for Mapping of Splice Sites in Cottontail Rabbit Papillomavirus," Journal of ... Vectors that contain the replicons from bovine papillomavirus or Epstein-Barr virus replicate extrachromosomally at "low copy ...
more infohttp://www.google.com/patents/US7384738?dq=5,966,702

RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral...RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral...

Cottontail rabbit papillomavirus (CRPV) induces papillomas in domestic rabbits which progress at a very high rate to cancer. ... In summary, our analyses confirmed that papillomaviruses have highly similar transcriptional patterns, but they do not suggest ... Persistent infections with high-risk human papillomaviruses (HPVs) can result in the development of cancer of the cervix uteri ... splice junctions 7810/3714 and 1751/3065 in both papillomas and carcinomas which have been described for other papillomaviruses ...
more infohttps://www.semanticscholar.org/paper/RNA-sequencing-analysis-identifies-novel-spliced-or-Probst-Hunczek-J%C3%A4ger/bc85cb94861befb0c0081c6c38eddd8919ee7c80

Molekulare Pathogenese der Malignome des Genitalbereichs | Springer for Research & DevelopmentMolekulare Pathogenese der Malignome des Genitalbereichs | Springer for Research & Development

1995) Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from ... Lin YL, Borenstein LA, Ahmed R, Wettstein FO (1993) Cottontail rabbit papillomavirus LI protein-based vaceines: protection is ... Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced ... Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-3-642-56297-6_12

Viruses  | Free Full-Text | The Mouse Papillomavirus Infection Model | HTMLViruses | Free Full-Text | The Mouse Papillomavirus Infection Model | HTML

This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a ... The model is a major step forward in the study of papillomavirus disease and pathology. In this review, we summarize studies ... The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective ... community has been searching for a mouse papillomavirus model since the identification of the cottontail rabbit papillomavirus ...
more infohttps://www.mdpi.com/1999-4915/9/9/246/htm

Revision #5 - dsDNA Viruses - dsDNA Viruses (2011) - International Committee on Taxonomy of Viruses (ICTV)Revision #5 - dsDNA Viruses - dsDNA Viruses (2011) - International Committee on Taxonomy of Viruses (ICTV)

Abbreviations: CRPV, cottontail rabbit papillomavirus; BPV, bovine papillomavirus; HPV, human papillomavirus.. Lipids. None ... in Human papillomavirus 61, Human papillomavirus 7, Human papillomavirus 6, Human papillomavirus 54, Human papillomavirus ... Type species Cottontail rabbit papillomavirus. Distinguishing features. Members of this genus cause cutaneous and mucosal ... Members of the species Human papillomavirus 5, Human papillomavirus 9 and Human papillomavirus 49 are also associated with the ...
more infohttps://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae/revision/5

Rabbit | Understanding Animal Research | Understanding Animal ResearchRabbit | Understanding Animal Research | Understanding Animal Research

The cottontail rabbit papillomavirus (CRPV) was the first animal model of cancer caused by a mammalian virus. It played a ... Rabbits use a litter and purr like cats. Rabbits can easily be trained to use a litter tray, sometimes better than the average ... Alerted by a friend to cotton tail rabbits with horns which were actually large warts; Shope ground up the horns, filtered ... 3. Rabbits are used as models for cystic fibrosis and cholera. The general physiology of rabbits is similar to that of humans, ...
more infohttp://www.understandinganimalresearch.org.uk/animals/10-facts/rabbit/

Human Papillomavirus Vaccine: A New Chance to Prevent Cervical Cancer | SpringerLinkHuman Papillomavirus Vaccine: A New Chance to Prevent Cervical Cancer | SpringerLink

Human papillomavirus (HPV) is a significant source of morbidity and mortality throughout the world and is the most common ... Breitburd F, Kirnbauer R, Hubbert NL et al (1995) Immunization with virus-like particles from cottontail rabbit papillomavirus ... Embers ME, Budgeon LR, Pickel M et al (2002) Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization ... A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 347:1645-1651PubMedCrossRefGoogle Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-3-540-37696-5_8

Code System ConceptCode System Concept

Cottontail rabbit papillomavirus (organism) {56794007 , SNOMED-CT } Application Version: 4.0.6.3. Content Version: 2019.10.03. ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=423513005

KAKEN - Research Projects | Studies on Biological Information and Control in Japan and China (KAKENHI-PROJECT-04045030)KAKEN - Research Projects | Studies on Biological Information and Control in Japan and China (KAKENHI-PROJECT-04045030)

Publications] M.Inoue and A.Seto: Chromosomal abnormalities and physical states of cottontail rabbit papillomavirus genome in ... Publications] M.Inoue and A.Seto: Chromosomal abnormalities and physical states of cottontail rabbit papillomavirus genome in ... Papillomavirus / Papilloma / Squamous cell carcinoma / Gastric cancer / Esophageal cancer / Oncogene. Research Abstract. This ... We analyzed the physical states of Shope papillomavirus(SPV) genome in a Shope carcinoma cell line and its four subline ; the ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04045030/
  • 5. Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system. (tuftsmedicalcenter.org)
  • Over the years, a number of rodent papillomaviruses have been isolated, cloned and sequenced but none of them infected laboratory mouse strains [ 2 ]. (mdpi.com)
  • RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral transcripts during progression of cottontail rabbit papillomavirus-induced tumours. (semanticscholar.org)
  • They demonstrated that the viral DNA shared homology with Mastomys natalensis papillomavirus DNA as well as with HPV11, -13, -16 and -18 by hybridization. (mdpi.com)
  • They are highly host-specific, cannot be propagated in tissue culture and, with the exception of some ungulate papillomaviruses, infect only epithelial cells. (inchem.org)
  • The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. (mdpi.com)
  • In 2011, a mouse papillomavirus (subsequently labeled MmuPV1) was identified in a colony of nude (NMRI-Foxn1 nu /Foxn1 nu ) mice in India [ 5 ]. (mdpi.com)
  • In the few years since it was first reported, MmuPV1 has become a valuable animal papillomavirus because it provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. (mdpi.com)
  • So we tried to make rabbit hepatic tumor model using new cell line prepared and developed in animal laboratory of Kosin University and Pusan National University. (medsci.org)
  • This study is a new AX7 hepatic tumor model for rabbits. (medsci.org)
  • One of these epitopes, spanning the amino acid (aa) region 17 to 38 of HPV-16 L2 (L2 17-38 ), has gained special attention, as antibodies recognizing this region show neutralizing activity against a broad range of different papillomavirus (PV) types ( 15 - 17 ). (asm.org)
  • One of the most common uses of rabbits in the laboratory is for the production of antibodies, used to detect the presence or absence of disease and for research into infectious diseases and immunology. (understandinganimalresearch.org.uk)
  • Analogous experimental studies were done in animal species such as rabbits, horses, cows and dogs, which suffer from similar wart-like diseases (see Table 1). (jacobspublishers.com)
  • Because VX2 easily grows when implanted into the liver of rabbits, and develops into discrete lesions, this currently serves as the only hepatocellular carcinoma (HCC) model for animals. (medsci.org)
  • We investigated sequential findings of immunohistochemistry of rabbit hepatic malignancy induced by AX7 cells. (medsci.org)
  • Rabbits were injected with concentrated protein extract with Freund's incomplete adjuvant. (asm.org)
  • This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. (mdpi.com)
  • Vaccinated rabbits were, however, protected against wart development on subsequent challenge with live virus. (asm.org)
  • identified papillomavirus DNA in hairless mouse tumors resulting from ultraviolet irradiation exposure [ 3 ]. (mdpi.com)
  • 13 rabbits implanted with AX7 cells directly into liver parenchyme with laparotomy were investigated by histopathology examination, immunohistochemistry, which is useful for the evaluation of metastatic cancer angiogenesis. (medsci.org)