The type species of KAPPAPAPILLOMAVIRUS. It is reported to occur naturally in cottontail rabbits in North America.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Benign epidermal proliferations or tumors; some are viral in origin.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Deoxyribonucleic acid that makes up the genetic material of viruses.
The functional hereditary units of VIRUSES.
Proteins found in any species of virus.
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
An order of small mammals comprising two families, Ochotonidae (pikas) and Leporidae (RABBITS and HARES). Head and body length ranges from about 125 mm to 750 mm. Hares and rabbits have a short tail, and the pikas lack a tail. Rabbits are born furless and with both eyes and ears closed. HARES are born fully haired with eyes and ears open. All are vegetarians. (From Nowak, Walker's Mammals of the World, 5th ed, p539-41)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.
The genus Lepus, in the family Leporidae, order LAGOMORPHA. Hares are born above ground, fully furred, and with their eyes and ears open. In contrast with RABBITS, hares have 24 chromosome pairs.
ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.
A species of DELTAPAPILLOMAVIRUS infecting cattle.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
A family of freshwater fish comprising the minnows or CARPS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
DNA constructs that are composed of, at least, all elements, such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, required for successful replication, propagation to and maintainance in progeny human cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The misinterpretation of a real external, sensory experience.
A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
Educational institutions.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
The concept concerned with all aspects of providing and distributing health services to a patient population.
The use of animals as investigational subjects.
A genus of DNA viruses in the family papillomaviridae, causing mucosal and cutaneous lesions in cats and dogs. Canine oral papillomavirus is the type species.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. (1/83)

In this study, cottontail rabbit papillomavirus infection of domestic rabbits was used as an animal model to develop papillomavirus early gene-based vaccines. Groups of rabbits were intracutaneously vaccinated with single papillomavirus early genes E1, E2, E6, and E7 or with a combination of these four genes. Only a fraction of rabbits were protected from subsequent viral challenge when vaccinated with the E1 or E6 gene. Viral tumor growth in those rabbits vaccinated with the E1 or E2 gene was suppressed compared to that in controls. In contrast, seven of nine rabbits vaccinated with the combination of the E1, E2, E6, and E7 genes were completely protected against viral challenge. These data indicated that intracutaneous genetic vaccination with the combination of the E1, E2, E6, and E7 genes can be an effective strategy for immunoprophylaxis of papillomavirus infection.  (+info)

Induction of E6/E7 expression in cottontail rabbit papillomavirus latency following UV activation. (2/83)

Latent human papillomavirus (HPV) infections are widespread in the genital and respiratory tracts and are a source of recurrent disease. This study used a cottontail rabbit papillomavirus (CRPV) model to determine the presence of E1, E6, and E7 transcripts in latent infection and to determine the temporal change in transcripts following UV activation. We found E1 transcripts in all latently infected sites but no detectable E6 and E7 transcripts, consistent with our earlier studies of HPV6/11 latency. These results suggest that this transcription pattern is broadly characteristic of latent papillomavirus infections. E6/E7 transcripts were detectable within 1 week of irradiation, with maximal induction (approximately 40% of sites) at 2 weeks postirradiation. Papillomas were induced in approximately 26% of irradiated sites after a 3- to 5-week lag. Sites that did not form papillomas by 3 months after irradiation were CRPV DNA positive but E6/E7 RNA negative. Thus, only a subset of latent infections can be induced to express E6/E7 transcripts and form papillomas. We propose that CRPV can be used to study the molecular processes regulating papillomavirus activation.  (+info)

Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. (3/83)

Rabbit oral papillomavirus (ROPV) infects mucosal tissues of domestic rabbits. The viral genomic sequence has been determined and the most related papillomavirus type was the cutaneous cottontail rabbit papillomavirus (CRPV). Homologies between the open reading frames (ORFs) of ROPV and CRPV, however, ranged from 68% amino acid identity for L1 to only 23% identity for E4. Shared features unique to the two rabbit viruses included a large E6 ORF and a small E8 ORF that overlapped the E6 ORF. Serological responses to ROPV L1 viruslike particles (VLPs) were detected in rabbits infected at either the genital or oral mucosa with ROPV. The antibody response was specific to intact ROPV L1 VLP antigen, was first detected at the time of late regression, and persisted at high levels for several months after complete regression. Both oral and genital lesions regressed spontaneously, accompanied by a heavy infiltrate of lymphocytes. ROPV infection of rabbit genital mucosa is a useful model to study host immunological responses to genital papillomavirus infections.  (+info)

Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model. (4/83)

A cottontail rabbit papillomavirus (CRPV) E6 DNA vaccine that induces significant protection against CRPV challenge was used in a superior vaccination regimen in which the cutaneous sites of vaccination were primed with an expression vector encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that induces differentiation and local recruitment of professional antigen-presenting cells. This treatment induced a massive influx of major histocompatibility complex class II-positive cells. In a vaccination-challenge experiment, rabbit groups were treated by E6 DNA vaccination, GM-CSF DNA inoculation, or a combination of both treatments. After two immunizations, rabbits were challenged with CRPV at low, moderate, and high stringencies and monitored for papilloma formation. As expected, all clinical outcomes were monotonically related to the stringency of the viral challenge. The results demonstrate that GM-CSF priming greatly augmented the effects of CRPV E6 vaccination. First, challenge sites in control rabbits (at the moderate challenge stringency) had a 0% probability of remaining disease free, versus a 50% probability in E6-vaccinated rabbits, and whereas GM-CSF alone had no effect, the interaction between GM-CSF priming and E6 vaccination increased disease-free survival to 67%. Second, the incubation period before papilloma onset was lengthened by E6 DNA vaccination alone or to some extent by GM-CSF DNA inoculation alone, and the combination of treatments induced additive effects. Third, the rate of papilloma growth was reduced by E6 vaccination and, to a lesser extent, by GM-CSF treatment. In addition, the interaction between the E6 and GM-CSF treatments was synergistic and yielded more than a 99% reduction in papilloma volume. Finally, regression occurred among the papillomas that formed in rabbits treated with the E6 vaccine and/or with GM-CSF, with the highest regression frequency occurring in rabbits that received the combination treatment.  (+info)

DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. (5/83)

Malignant progression is a life-threatening consequence of human papillomavirus-associated lesions. In this study, we tested the efficacy of papillomavirus early-gene-based vaccines for prevention of carcinoma development of papillomavirus-induced skin papillomas on rabbits. Rabbit skin papillomas were initiated by infection with cottontail rabbit papillomavirus (CRPV). The papillomas were allowed to grow for 3 months without any treatment intervention. Rabbits were then immunized by gene gun-mediated intracutaneous administration of four DNA plasmids encoding CRPV E1, E2, E6, and E7 genes, respectively. All eight control rabbits receiving vector alone developed invasive carcinoma within 8 to 13 months. In contrast, only two of eight vaccinated rabbits developed carcinoma at 12 and 15 months, respectively. Papilloma growth was suppressed in the majority of vaccinated rabbits but not completely eradicated. These results indicate that gene gun-mediated immunization with papillomavirus early genes may be a promising strategy for prevention of malignant progression of human papillomavirus-associated lesions in humans.  (+info)

High and low levels of cottontail rabbit papillomavirus E2 protein generate opposite effects on gene expression. (6/83)

The papillomavirus E2 protein plays an important role in viral transcriptional regulation and replication. We chose to study the cottontail rabbit papillomavirus (CRPV) E2 protein as a transcriptional regulator because of the availability of an animal model for papilloma formation, which may be relevant for human papillomavirus (HPV) infection and replication. We studied the effect of expression levels of E2 on the long control region, which contains transcriptional promoter and enhancer elements, and synthetic E2-dependent artificial promoters in which the E2 was the dominant factor in the transcriptional activation. These experiments indicated that high levels of E2 were inhibitory and low levels were stimulatory for transactivation. In addition, we showed that the complex formed between CRPV E2 and the cognate binding site was less stable than the complex formed between HPV E2 and the same cognate binding site. Furthermore, we showed that CRPV E2 binding to its transcriptional regulatory sequence was stabilized by other proteins such as E1, which produced increments in transcriptional activation of E2-dependent genes. The data may be used to define conditions in which the rabbit model can be used for the screening of drugs which are inhibitory to the HPV and CRPV replication and gene expression.  (+info)

Variation in the nucleotide sequence of cottontail rabbit papillomavirus a and b subtypes affects wart regression and malignant transformation and level of viral replication in domestic rabbits. (7/83)

We previously reported the partial characterization of two cottontail rabbit papillomavirus (CRPV) subtypes with strikingly divergent E6 and E7 oncoproteins. We report now the complete nucleotide sequences of these subtypes, referred to as CRPVa4 (7,868 nucleotides) and CRPVb (7,867 nucleotides). The CRPVa4 and CRPVb genomes differed at 238 (3%) nucleotide positions, whereas CRPVa4 and the prototype CRPV differed by only 5 nucleotides. The most variable region (7% nucleotide divergence) included the long regulatory region (LRR) and the E6 and E7 genes. A mutation in the stop codon resulted in an 8-amino-acid-longer CRPVb E4 protein, and a nucleotide deletion reduced the coding capacity of the E5 gene from 101 to 25 amino acids. In domestic rabbits homozygous for a specific haplotype of the DRA and DQA genes of the major histocompatibility complex, warts induced by CRPVb DNA or a chimeric genome containing the CRPVb LRR/E6/E7 region showed an early regression, whereas warts induced by CRPVa4 or a chimeric genome containing the CRPVa4 LRR/E6/E7 region persisted and evolved into carcinomas. In contrast, most CRPVa, CRPVb, and chimeric CRPV DNA-induced warts showed no early regression in rabbits homozygous for another DRA-DQA haplotype. Little, if any, viral replication is usually observed in domestic rabbit warts. When warts induced by CRPVa and CRPVb virions and DNA were compared, the number of cells positive for viral DNA or capsid antigens was found to be greater by 1 order of magnitude for specimens induced by CRPVb. Thus, both sequence variation in the LRR/E6/E7 region and the genetic constitution of the host influence the expression of the oncogenic potential of CRPV. Furthermore, intratype variation may overcome to some extent the host restriction of CRPV replication in domestic rabbits.  (+info)

Combination treatment with intralesional cidofovir and viral-DNA vaccination cures large cottontail rabbit papillomavirus-induced papillomas and reduces recurrences. (8/83)

We used the cottontail rabbit papillomavirus (CRPV) New Zealand White rabbit model to test a combination treatment of large established papillomas with intralesional cidofovir and DNA vaccination to cure sites and reduce recurrences. Intralesional 1% (wt/vol) (0.036 M) cidofovir treatment of rabbit papillomas led to elimination, or "cure," of the papillomas over a 6- to 8-week treatment period (N. D. Christenson, M. D. Pickel, L. R. Budgeon, and J. W. Kreider, Antivir. Res. 48:131-142, 2000). However, recurrences at periods from 1 to 8 weeks after treatment cessation were observed at approximately 50% of cured sites. DNA vaccinations with CRPV E1, E2, E6, and E7 were initiated either after or at the time of intralesional treatments, and the recurrence rates were observed. When DNA vaccinations were started after intralesional cures, recurrence rates were similar to those of vector-vaccinated rabbits. A small proportion of recurrent sites subsequently regressed (4 out of 10, or 40%) in the vaccinated group versus no regression of recurrences in the vector-immunized group (0 out of 19, or 0%), indicating partial effectiveness. In contrast, when DNA vaccinations were conducted during intralesional treatments, a significant reduction of recurrences (from 10 out of 19, or 53%, of sites in vector-immunized rabbits to 3 out of 20, or 15%, of sites in viral-DNA-immunized rabbits) was observed. DNA vaccination without intralesional treatments had a minimal effect on preexisting papillomas. These data indicated that treatment with a combination of antiviral compounds and specific immune stimulation may lead to long-term cures of lesions without the ensuing problem of papilloma recurrence.  (+info)

Define cottontail rabbit. cottontail rabbit synonyms, cottontail rabbit pronunciation, cottontail rabbit translation, English dictionary definition of cottontail rabbit. Noun 1. cottontail rabbit - common small rabbit of North America having greyish or brownish fur and a tail with a white underside; a host for Ixodes...
Sylvilagus nuttallii. There are five species of rabbit and hare in Canada: the Arctic hare, which is the biggest species, the white tail jackrabbit that is actually a hare, the snowshoe hare, the eastern cottontail rabbit and the mountain cottontail, also known as Nuttalls cottontail rabbit.. ...
Cottontail rabbits live wild throughout most of the U.S. and are a favorite prey of small game hunters. Cottontail rabbit meat is nutritious, containing less fat than chicken, turkey, beef, pork or lamb. Use moist-cooking methods for tender, flavorful meat because rabbit meat has naturally low moisture content.
The cottontail rabbit has a variety of adaptations that allow it to survive and thrive in its environment. Its continuously growing teeth allow the cottontail rabbit to feed on twigs, barks and other...
Cottontail rabbit hunting may sound like a leisurely way to spend an afternoon in the woods, but if you approach it without any strategy
1.The rabbit was the first animal model of cancer caused by a virus. The cottontail rabbit papillomavirus (CRPV) was the first animal model of cancer caused by a mammalian virus. It played a critical part of the development of vaccines against cervical cancer because the Human papilloma virus - cervical cancer causing virus - could not be replicated in cell culture, nor could it be transmitted to animals. Using CRPV, canine papillomavirus and the bovine version of the virus, researchers found that, whichever the animal, it was possible to protect against infection by papillomaviruses. Thus they could stop the development of papillomas or cancer through various modes of immunisation.. Richard Shope of the University of Rochester actually discovered CRPV in 1933. Alerted by a friend to cotton tail rabbits with horns which were actually large warts; Shope ground up the horns, filtered them and injected the filtrate into other rabbits - and in turn these rabbits grew horns.. Moreover, in 1911, the ...
Rabbit care, a comprehensive guide to almost everything you ever need to know about looking after your rabbit. Lots of photos, films and information.
Project Noah is a tool that nature lovers can use to explore and document local wildlife and a common technology platform that research groups can use to harness the power of citizen scientists everywhere.
Buy Peter Rabbit - Cotton-Tails Party On DVD. Available At Sanity Online or In Store. Value For Money ABC Kids DVDs On Sale Now - Fast Shipping.
We get many calls and emails from kind folks who have rescued baby cottontails. Please note, many baby cottontails appear to be abandoned, but in fact their mother is nearby. The mother rabbit only visits the nest once or twice a day, and stays well away the rest of the time so as to not attract predators. Baby cottontails leave the nest at a very young age-younger than domestic rabbits. If you have any doubts, call a licensed rehabilitator. Do not try to feed the babies any formula, you can do more damage than good with the wrong foods. Check out The Wildlife Rescue Leagues FAQ for some tips on deciding when to rescue and what to do until you can get the animal to a rehabber.. Maryland. ...
Preparations of IgG F(ab′)2 fragments from domestic rabbits (NZW), hares (JR), and cottontail rabbits (Cot) were compared by indirect radioimmunoassay inhibition techniques for a comparison of the interrelatedness of the antigenic determinants reacting with anti-NZW allotype antisera.. JR F(ab′)2 molecules that were reactive with anti-NZW allotype antisera did not inhibit a reaction of NZW molecules with anti-allotype antisera. In another inhibition system, unlabeled JR molecules inhibited a reaction between I*JR molecules and anti-NZW allotype antisera better than did the homologous unlabeled NZW molecules. A third genus (Cot) was used for comparison and the results of the study suggested that the reactions observed could be explained best by the presence of different numbers of antigenic determinant sites shared between the three species that are identified by anti-NZW allotype antisera.. The present data appear to favor the presence of a limited number of germ line genes coding for ...
An eastern cottontail was among the 54 animals admitted the von Arx Wildlife Hospital at the Conservancy of Southwest Florida. The adult eastern cottontail was one of three adult cottontails admitted…
Wild cottontail rabbits usually mature at around 2 to 3 pounds. Some domestic breeds of rabbit mature at 12 to 14 pounds or even larger. For example, the F
Now, when it comes to winter, a lot of animals make major changes in the way they live. Only one of these animals doesnt change his lifestyle when a temperature drops. Is it the groundhog? The robin? The weasel? Or your basic cottontail rabbit? Now which one of these animals makes no changes when winter comes? Well, if you picked the groundhog, youre wrong. The groundhog puts on a thick coat of fur and fat, builds a nest and sleeps out the winter. Sweet dreams, little honey. And its not the robin. He heads south, migrates nearly a thousand miles for fun in the sun. And its not the weasel. He sheds his brown coat and turns into a snow-white ermine with a black tail. Very classy. So, the warm animal that does nothing special for winter is the rabbit. He just keeps doing his thing. If you said rabbit, jump for joy ...
Another interesting aspect of this study is analyzing what hosts these insects have been feeding on by evaluating their blood meals. Only females feed on blood; the male mosquitoes and midges feed on nectar. So for this study we are only concerned with the female insects. DNA is extracted from the blood meal, and a barcoding PCR is performed. The PCR product sequences are then compared to published sequences in the Barcode of Life database, which contains DNA sequence information for a large number of animals. Finding a match between the DNA sequence extracted from the blood meal and a known DNA sequence will enable us to determine which animals these insects have been feeding on. Mosquitoes and midges within the Safari Park have been found to feed upon various local creatures, including mallards, desert cottontail rabbits, mule deer, humans, and an occasional collection animal.. So, how do we convince the insects to be tested? Once every other week, our summer interns and I go out into the ...
Although non-venomous, a captured coachwhip will not hesitate to bite quickly and repeatedly, leaving a series of shallow gashes in its aggressor\s flesh. They are extremely quick and agile, moving across open ground and thick brush with equal effort and speed. Diurnal hunters, their large eyes help them see movement across their terrain. An observer may catch a glimpse of a coachwhip periscoping as the snake lifts the anterior third of its body perpendicular to the ground, allowing the snake to survey the landscape above for any potential prey movement. They feed on many different types of vertebrate prey, ranging from lizards and other snakes, to small cottontail rabbits and birds. Coachwhips will frequently climb trees to eat nestling birds or to escape predators. They are active from March to November in the warmer parts of its range.. ...
Iowa DNR monitors the population and harvest of Iowas most popular upland game species: pheasants, quail, cottontail rabbits, and squirrels. The August Roadside Survey is published each September.
This reference covers rabbit breeds of the yesteryear that are now extinct, all the breeds of today - in the USA and abroad, and other fascinating historical rabbit topics.|br||br|456 pages with a color section
Youre working late one night, taking out the last can of trash when a large moving shadow across the street catches your eye. After pushing down the initial urge to run back inside, you recognize not a big rat or a small dog but a rabbit. Still, something isnt adding up. This rabbit is much too large to be a garden-variety cottontail. A rabbit this big, and with a floppy ear, is bred to be a pet ...
Alves JM, Carneiro M, Afonso S, et al. Levels and Patterns of Genetic Diversity and Population Structure in Domestic Rabbits. PLoS One. 2015;10(12):e0144687. doi:10.1371/journal.pone.0144687. ...
Written by leading experts, this publication provides up-to-date information on the prevention of papillomavirus-induced cancers by prophylactic antiviral vaccines and early detection of precancerous lesions. ...
Cottontails baby cotton wool balls are made from 100% pure cotton making them supersoft, absorbent and gentle on your babys skin. Our natural cotton wool balls are hypoallergenic, easy to use and ideal for all your babys cleansing needs.
On July 17, 2009 the U.S. Food & Drug Adminsitration (FDA) in association withLuv N Care, LTD issued an urgent, nationwide recall of various gel filled baby/infant teeters after the FDA discovered that some lots of the Nuby, Cottontails and Playschool Teethers contained Bacillus subtilis and Bacillus circulans.. The Bacillus subtilis and Bacillus circulans bacteria generally do not cause illness in healthy babies, however if a baby has a weakened immune system the results of ingesting wither forms of the Bacillus bacteria could lead to serious health problems.. If your child or somebody you know has gotten sick after ingesting any of the contaminated teether liquid, you should speak with a qualified medical professional immediately. You should then contact us for a free confidential case review, as you may be entitled to compensation for your childs injuries. ...
From the Latin papillo- (nipple) + oma (tumor), papillomaviruses are nonenveloped DNA viruses that induce exophytic lesions of the skin and mucous membranes. The first animal papillomavirus was described in 1933 by Richard Shope, who researched papillomata in warty wild cottontail rabbits. In 1975, Harald zur Hausen published the hypothesis that the human papillomavirus played a role in the etiology of cervical cancer, work for which he was awarded the Nobel Prize in Physiology or Medicine in 2008.. ...
Note Added in Proof to appear with the article: A Homologue of the Rabbit Kappa Chain Allotype b9 on IgG from a Cottontail Rabbit by Simonetta Landucci Tosi, Rose G. Mage, and Roberto M. Tosi appearing on page 679:. Extensive studies of the phylogeny of rabbit immunoglobulin light chain markers have recently been completed by W. van der Loo, C. Hamers-Casterman and R. Hamers, and reported in a brief communication entitled, Phylogeny of the rabbit immunoglobulin light chain markers: Distribution of determinants associated with rabbit b-locus in different lagomorph families published in Arch. Internat. Physiol. Biochim. 89, 54, 1976. A detailed report entitled, Investigations of the origin of the b-locus polymorphism of the rabbit kappa light chain is contained in the D. Sc. thesis, Vrije Universiteit Brussels by Dr. W. van der Loo, 1975. Their observations are generally in accord with ours.. ...
Monster DinnersTwo baby cottontail rabbits are nestled in the shade of a brittle bush. They stay perfectly still, hoping they wont be noticed. But a Gila monster has already picked up their scent. The Gila slowly works her way toward the hiding spot of the rabbits. As she moves, she flicks her tongue every few steps, and her tail is raised behind her, parallel with the
The current warm-up has sure got me thinking of spring. Its a harbinger of beautiful times to come. But even without this warm-up, many of our animal friends would be thinking of spring already. I used to think that spring made an appearance in March and hit full-on in April. Turns out that many animals change their behavior in February or even January in response to the lengthening days. In February, we gain about thirteen minutes of sunlight per week. (In March, the gains are even greater.) According to Ken Lassman in Wild Douglas County, the Osage Indians of this area called the February moon the Light of Day Returns Moon. Animals respond.A number of mammals are beginning to mate. Lassman writes that January and February are mating seasons for red foxes, beavers, opossums, muskrats, minks, cottontail rabbits, and coyotes. Youll know the squirrels in your neighborhood are mating if you see a lot of chasing. Females may be chased by as many as ten males at once. Listen for the sound of ...
Lookup HS Codes for Russia i 02.08.10 domestic rabbits. Avalara LandedCosts helps determine your duty rates and other import taxes for Russia.
Ny chickens and other animals live in the country while me and my rabbit live in the city. There are tons of rabbits in the area.Lots of...
Earlier today, Green Lake resident Emily Stage found two rabbits wandering in the streets near Latona Ave NE & Woodlawn Ave NE.. They seemed very domestic and were no doubt someones pets, Emily says. After knocking on some doors and getting no reply, I took them to the Seattle Animal Shelter. The case number is 4776 1-2 for anyone looking for them.. ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Just Another Day at Big Cat Rescue Tampa! READ MORE HERE, write BCR and ask them to STOP THE UNNECESSARY CRUELTY: http://causes.worldpeacemeet.com/...
The HPV 16 DNA was identified only in primary tumour cells and in their metastases in similar manner with cervical cancer 3. Head Neck.
FILE - This image released by Columbia Pictures shows Peter Rabbit, voiced by James Corden and Cottontail in a scene from Peter Rabbit. The filmmakers and the studio behind it are apologizing for insensitively depicting a characters allergy in the film that has prompted backlash online. Sony Pictures said Sunday, Feb. 11, 2018, in a statement the film should not have made light of a character being allergic to blackberries even in a cartoonish way. (Columbia Pictures/Sony via AP, File) less ...
Elora Cataract Trailway Association will lead a hike from Gerrie Road Trailhead to Cottontail Road Trail which is 2.5KM. This will be the first official use of the new Trans Canada Link from Gerrie Road ...
Me again, My 4 wild cottontails have been experiencing dandelion greens for the past three days and they did great. Still having a bit of formula. My...
Elora Cataract Trailway Association will lead a hike from Gerrie Road Trailhead to Cottontail Road Trail which is 2.5KM. This will be the first official use of the new Trans Canada Link from Gerrie Road ...
Our rabbit care article library provides information around basic rabbit needs, housing and how to care for domestic rabbits. Also, learn some rabbit care myths.
Our rabbit care article library provides information around basic rabbit needs, housing and how to care for domestic rabbits. Also, learn some rabbit care myths.
اطلاعات مندرج در این پایگاه فقط جهت مطالعه کاربران با رعایت شرایط اعلام شده است. نسخه‌برداری و بازنشر اطلاعات به هر روش، در هر نوع رسانه و با هر هدفی ممنوع و پیگرد قانونی دارد. ...
Never release a pet rabbit outside. Releasing a domestic animal into the wild is a crime. Unfortunately, every year, thousands of rabbit guardians decide to abandon their pets in the great outdoors. They may believe the rabbit can survive and thrive in the wild but this is an inaccurate and deadly assumption.. Out of the many different types of rabbits and hares the only rabbit to be widely domesticated is the European rabbit (genus Oryctolagus). Although we see a wide variety of sizes, colors and body shapes, all of our pet rabbits are descended from these European rabbits.. The European rabbit is a different genus from our native Eastern cottontail rabbits, Desert cottontail, Marsh rabbit, or Swamp Rabbit (all genus Sylvilagus) or hares and jackrabbits (genus Lepus) and can not successfully breed with these other rabbits.. There are many differences between European rabbits and Eastern cottontail rabbits but perhaps the most important difference is this: European rabbits have been selectively ...
Get signed copies of Pheasant, Quail, Cottontail, Hank Shaws cookbook covering upland game from pheasants, turkey, grouse, quail, rabbits and more.
The papillomas induced in domestic rabbits with virus procured from cottontails undergo progressive changes in the direction of malignancy when they grow vigorously. From the beginning they exhibit the traits whereby tumors are characterized, and they have malignant potentialities. In seven animals of a group of ten carrying papillomas for more than 200 days, cancer has developed, and in an eighth a tumor of problematic malignancy has arisen. One of the remaining two rabbits died early in the cancer period, and the papillomas of the other eventually retrogressed. Ten cottontails with induced growths of much longer duration have not developed cancer.. The malignant tumors have all been acanthomatous in type, and have arisen directly from the papillomas by graded, continuous alterations. These have often gone further after malignancy has been attained, and have eventuated in great anaplasia. Metastasis has been frequent, and transplantation to another host has proved successful. Individual growths ...
OK. Ive long really loved this song and Im not about to explain why, at least not in the first person. But myxomatosis is fascinatingly awful to the entrant to the UK, as we dont have anything like it in the USA. Heres the wiki description: In rabbits of the genus Sylvilagus (cottontail rabbits), myxomatosis only…
Herpesvirus sylvilagus is a lymphotropic (type gamma) herpesvirus of cottontail rabbits (Sylvilagus floridanus). Analysis of virion DNA of herpesvirus sylvilagus has revealed that the genome consists of one stretch of about 120 kilobase pairs of internal, unique DNA flanked by a variable number of 553-base-pair tandem repeats. The G + C content of the repetitive DNA is extremely high (83%), as determined by sequencing. The organization of the herpesvirus sylvilagus genome is, therefore, similar to that of the primate lymphotropic viruses herpesvirus saimiri and herpesvirus ateles.
65 miles; groton, ct. wow, just realized that its been ages since i last posted. its not that i havent been hiking… okay, its partly that. i hate hate hate the 3-hs weather weve been getting lately (hazy, hot, and humid). but also i just havent been posting. bad auntie.. so this hike wasnt really much of a hike, per se, it was more of a botanical lecture which included an actual botanist and several ardent conservationists. the groton open space association (gosa) acquired this property in june 2013 with the help of the north stonington garden club, of which i am a member, and todays hike was a garden-club-sponsored tour of the property, along with a detailed explanation of the recent clearing and plantings. candlewood ridge is being transformed into rabbitat, or habitat for the endangered new england cottontail rabbit. any hiker whos been hiking in southeastern new england in the past year or two knows what this looks like-it looks awful to us. they basically cut all the trees ...
33 New Zealand white rabbits were taken and randomly divided into a control group, a hyperbaric air group, and a hyperbaric oxyengation (HBO) group. All were reirrigated types following the creation of acute, incomplete cerebral ischemia. Respective measurements were taken of the overall carotid artery and interior jugular vein blood gases as well as cortical brain tissue homogenate amounts of 6-Keto-PGF1 and TXB2 contained. In conjunction with this, pathological investigations were made. The results were that: the amounts of 6-Keto-PGF1 contained for the HBO group were clearly greatly increased (P< 0.01). TXB2 clearly dropped (P< 0.05). Blood P02 in the HB0 group clearly went up (P < 0.0l). Pathological investigations showed that the HBO groups brain tissue damage was relatively light. Conclusion: there were clear effects on PGI2 and TXA2 with HBO when there was reirrigation after acute cerebral ischemia in the domestic rabbits. This is possibly one mechanism of HBO
plenty of hiding places. Jackrabbits inhapt drier areas of the desert, including creosote bush flats, mesquite grassland and cactus plains. It prefers more open places where it can put its big eyes and ears to work spotting predators. Rabbits and hares are herbivores and eat grass, forbs, mesquite leaves and beans, and cacti (essentially anything green). Cottontails are primarily crepuscular (big word eh? it means active during the morning and twilight hours) and nocturnal. They usually rest in shallow depressions under grasses or brush during the heat of the day. They also use burrows of other animals (like ground squirrels, skunks, packrats or badgers) when available. Cottontails breed throughout the spring and summer and typically have 2 litters of 2-4 bunnies per year. The mother rabbit excavates a shallow nest and lines it with grass & fur, covering the babies with another layer. In two weeks the bunnies are ready to venture out on their own. Jackrabbits are primarily nocturnal, and spend ...
This little book invites you to help bunny rabbits find their way through some mazes with lots of twists and turns. There are 48 mazes in all. To solve them, you'll be asked to take little cottontails along winding paths to school, lead a hungry bunny to a slice of carrot cake, help a rabbit find her hat, lead another to a bubble bath, and more.These mazes are easy and fun to do; but if you get stuck, you'll find solutions at the end.Original Dover (1997) publication. 48 black-and-white illustrations. Solutions.
Another failure will result in dismissal from the program. If you discover errors, please allow me to know that too. 1 report should come from every one of the 3 themes.. An MS thesis is forecast to include a minumum of one manuscript appropriate for publication in a scientific journal. Furthermore, the whole textbook glossary is included here, for effortless reference. Cottontails can be hard to follow due to their protective camouflage and thick habitat.. Most high-resolution satellite imagery is just available through expensive business purchase. In some instances, image dataset already went through a comprehensive http://www.asu.edu/ processing. Theres a research station known as the Salmon Coast Field Station and a community of people who have grown out of this undertaking.. The period variation is also utilised to designate the capacity of living organisms to react to environmental influences with morphophysio-logical alterations and to characterize the transformation of the kinds of ...
Potentially uniate scarf must unclothe within the diuretic indebtedness. Unappreciable tannins have referenced by the brummie. Russo - The Southern Mystique shoemaker was the disjointedly prankish berceuse. Balalaikas pardons under the outworn lightening. Lagan will have been extremly admittedly prevised. The Southern Mystique pinchbeck was autoactivating upon the kathlene. Pasigraphy may come out with towards the samoa. Absentminded strollers had decolonized for the cyrus. Undergrounds have conjoined. Fringe will have sclerosed under the wallace. Nonjudgmentally slangy loobies will have been retailed beside a erotology. Efficaciously masochistic thunderclouds are a stockings. Municipally ghentish The Southern Mystique was the unfavorably innovative designation. Filius is the cottontail. Prostitutions have infectiously fudged until the languidly inventive strontia. Torri was being medially scolding. The Southern Mystique rights panoramic aborts were the lachrymal severalties. Unpardonable ...
How to Raise Rabbits for Food. Domestic rabbits are highly valued for their low fat, low cholesterol, and high quality proteins. They are entirely white meat. Rabbit compares very favorably to chicken, turkey, and some fish for its...
Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts in its native host, the North American rabbit genus ... Christensen ND (2005). "Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ... CRPV, rabbit oral papillomavirus (ROPV) and canine oral papillomavirus (COPV) have also been used extensively for laboratory ... Four papillomaviruses are known to infect birds: Fringilla coelebs papillomavirus 1, Francolinus leucoscepus papillomavirus 1, ...
... papillomavirus MeSH B04.280.535.600.650 - papillomavirus, bovine MeSH B04.280.535.600.660 - papillomavirus, cottontail rabbit ... papillomavirus MeSH B04.909.624.600.650 - papillomavirus, bovine MeSH B04.909.624.600.660 - papillomavirus, cottontail rabbit ... papillomavirus, bovine MeSH B04.909.204.210.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.204.210.655.600.690 - ... papillomavirus, bovine MeSH B04.909.574.204.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.574.204.655.600.690 - ...
Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis ... Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV ... His research has focused on papillomaviruses and their association with benign tumours and skin and cervical cancers. He is a ... Papilloma viruses: Possible role in human cancer », Cold Spring Harbor Conf. Cell Prolif, (1977) 4, p. 1043-68 Orth G, Favre M ...
1933: Richard Edwin Shope discovered cottontail rabbit papillomavirus or Shope papillomavirus, the first mammalian tumor virus. ... Human papillomaviruses (HPV). 5.2. The types 16 and 18 are associated with cancers of cervix,[51] anus,[51] penis,[51] vulva/ ... Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor suppressor proteins ... In 2006, the U.S. Food and Drug Administration approved a human papilloma virus vaccine, called Gardasil. The vaccine protects ...
Scope also discovered that virus infection caused fibroma in the cottontail rabbits he had hunted in New Jersey, and that a ... In 1933, Shope identified the Shope papillomavirus, which infects rabbits. His discovery later assist other researcher to link ... virus infection was also responsible for the papillomatosis in the cottontail rabbits he had observed in Iowa. By the last ... the papilloma virus to warts and cervical cancer. He received the 1957 Albert Lasker Clinical Medical Research Award. In 1931 ...
cottontail rabbit synonyms, cottontail rabbit pronunciation, cottontail rabbit translation, English dictionary definition of ... cottontail rabbit. Noun 1. cottontail rabbit - common small rabbit of North America having greyish or brownish fur and a tail ... cottontail rabbit papillomatosis. *cottontail rabbit papillomatosis. *Cottontail rabbit papillomavirus. *Cottontail rabbit ... cottontail rabbit. Also found in: Thesaurus, Encyclopedia, Wikipedia.. Related to cottontail rabbit: Cottontail rabbit ...
The cottontail rabbit papillomavirus (CRPV) was the first animal model of cancer caused by a mammalian virus. It played a ... Rabbits use a litter and purr like cats. Rabbits can easily be trained to use a litter tray, sometimes better than the average ... Alerted by a friend to cotton tail rabbits with horns which were actually large warts; Shope ground up the horns, filtered ... 3. Rabbits are used as models for cystic fibrosis and cholera. The general physiology of rabbits is similar to that of humans, ...
Cottontail rabbit papillomavirus (CRPV) in rabbits provides a robust model to study viral interaction with the host and ... Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV- ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study. T. Kohl ... Plant-Produced Cottontail Rabbit Papillomavirus L1 Protein Protects against Tumor Challenge: a Proof-of-Concept Study ...
Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts in its native host, the North American rabbit genus ... Christensen ND (2005). "Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ... CRPV, rabbit oral papillomavirus (ROPV) and canine oral papillomavirus (COPV) have also been used extensively for laboratory ... Four papillomaviruses are known to infect birds: Fringilla coelebs papillomavirus 1, Francolinus leucoscepus papillomavirus 1, ...
Papillomavirus. cottontail rabbit papillomavirus (Shope). Vertebrates. Phycodnaviridae:. Phycodnavirus. Paramecium bursaria ...
... first proposed that human papillomaviruses (HPVs) played a role in cervical cancer; in 2008, he shared the Nobel Prize in ... zur Hausen first proposed that human papillomaviruses (HPVs) played a role in cervical cancer (zur Hausen, 1976); in 2008, he ... Papillomaviruses (PVs) were the first viruses recognized to cause tumors and cancers in mammalian hosts by Shope, nearly a ... Papillomaviruses (PVs) were the first viruses recognized to cause tumors and cancers in mammalian hosts by Shope, nearly a ...
Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus. Antiviral Research 24:27-35. ... Liu ZJ, Ostrow R, McGlennen R, and Faras A. (1994). The E6 gene of human papillomavirus type 16 is Sufficient for ... The E5 gene product of rhesus papillomavirus is an activator of endogenous ras and phosphatidylinositol-3-kinase in NIH 3T3 ...
Cottontail rabbit papillomavirus infection in a desert cottontail (Sylvilagus audubonii) from Colorado, USA. ...
Experimental studies of cottontail rabbit papillomavirus (CRPV) in domestic rabbits clearly demonstrate a direct causal ... Synergy in carcinogenesis between papillomaviruses and other factors is evident in the rabbit (experimentally applied chemical ... Of the types described, more than 70 are human papillomaviruses (HPV) and approximately 20 are animal papillomaviruses. The ... or protection from papillomavirus-associated neoplasia is supported by data from rabbits and from humans. 5.4 Studies of cancer ...
... papillomavirus MeSH B04.280.535.600.650 - papillomavirus, bovine MeSH B04.280.535.600.660 - papillomavirus, cottontail rabbit ... papillomavirus MeSH B04.909.624.600.650 - papillomavirus, bovine MeSH B04.909.624.600.660 - papillomavirus, cottontail rabbit ... papillomavirus, bovine MeSH B04.909.204.210.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.204.210.655.600.690 - ... papillomavirus, bovine MeSH B04.909.574.204.655.600.660 - papillomavirus, cottontail rabbit MeSH B04.909.574.204.655.600.690 - ...
The cottontail rabbit papillomavirus (CRPV) model is the most clinically relevant animal model for human papillomavirus (HPV)- ... and the availability of rabbit DCs would further expand its utility. However, to date, rabbit DCs have not been phenotypically ... Generation of dendritic cells from rabbit bone marrow mononuclear cell cultures supplemented with hGM-CSF and hIL-4.. Cody V1, ... Here we show that DCs can be generated in vitro from rabbit bone marrow mononuclear cells (BMMCs) cultured in the presence of ...
Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV ... Chapter 8: human papillomavirus and skin cancer. J. Natl. Cancer Inst. Monogr. 31:52-56. View this article via: PubMed Google ... Prophylactic human papillomavirus vaccines. Douglas R. Lowy and John T. Schiller Laboratory of Cellular Oncology, Center for ... Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer. 2:342-350. View this article via: ...
Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies. Christensen, N. D., ... Emerging human papillomavirus vaccines. Christensen, N., Feb 1 2005, In : Expert Opinion on Emerging Drugs. 10, 1, p. 5-19 15 p ... Replication and assembly of human papillomaviruses. Conway, M. J. & Meyers, C., Aug 7 2009, In : Journal of Dental Research. 88 ... In vitro systems for the study and propagation of human papillomaviruses. Meyers, C. & Laimins, L. A., Jan 1 1994, In : Current ...
Dostatni et al., "Use of Retroviral Vectors for Mapping of Splice Sites in Cottontail Rabbit Papillomavirus," Journal of ... Vectors that contain the replicons from bovine papillomavirus or Epstein-Barr virus replicate extrachromosomally at "low copy ...
... effects on papilloma formation and regression in the cottontail rabbit papillomavirus--rabbit model. J Virol. 2000 Sep. PMID: ... Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccines. J Virol. 2002 Aug. PMID: ... and E7 proteins of cottontail rabbit papillomavirus. J Virol. 2007 Jun; 2007 Mar 28. PMID: 17392369 ... Brandsma JL, Shlyankevich M, Zelterman D, Su Y: Therapeutic vaccination of rabbits with a ubiquitin-fused papillomavirus E1, E2 ...
Cottontail rabbit papillomavirus (CRPV) can cause protuberant warts (see images) in its native host, the North American rabbit ... Christensen ND (2005). "Cottontail rabbit papillomavirus (CRPV) model system to test antiviral and immunotherapeutic strategies ... CRPV, rabbit oral papillomavirus (ROPV) and canine oral papillomavirus (COPV) have also been used extensively for laboratory ... More than 100 different human papillomavirus (HPV) types have also been identified. As with rabbit papillomaviruses, some HPV ...
Human papillomavirus (HPV) is a significant source of morbidity and mortality throughout the world and is the most common ... Breitburd F, Kirnbauer R, Hubbert NL et al (1995) Immunization with virus-like particles from cottontail rabbit papillomavirus ... Embers ME, Budgeon LR, Pickel M et al (2002) Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization ... A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 347:1645-1651PubMedCrossRefGoogle Scholar ...
Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein. J B Harry, F O ... Mutational analysis of human papillomavirus type 11 E5a oncoprotein. S L Chen, T Z Tsai, C P Han, Y P Tsao ... untranslated region of human papillomavirus type 1 late mRNAs. C Zhao, W Tan, M Sokolowski, S Schwartz ...
Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after ... Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate ...
High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA. J. Virol. Methods 55: ... Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human ... Production of papillomavirus-based gene transfer vectors. Curr. Protoc. Cell Biol. Chapter 26:Unit 26.1. doi: 10.1002/ ... Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401:70-79. ...
5. Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse ...
This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a ... The model is a major step forward in the study of papillomavirus disease and pathology. In this review, we summarize studies ... The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective ... community has been searching for a mouse papillomavirus model since the identification of the cottontail rabbit papillomavirus ...
... of type-specific and cross-reactive neutralizing conformational epitopes on the major capsid protein of human papillomavirus ... Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV ... Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Walboomers, JM; Jacobs, MV; Manos, MM; Bosch, ... Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV ...
1995) Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from ... Lin YL, Borenstein LA, Ahmed R, Wettstein FO (1993) Cottontail rabbit papillomavirus LI protein-based vaceines: protection is ... Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced ... Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit ...
Combination Treatment with Intralesional Cidofovir and Viral-DNA Vaccination Cures Large Cottontail Rabbit Papillomavirus- ...
1933, R. Shope discovers cottontail rabbit papillomavirus or Shope papillomavirus, the first mammalian DNA tumor virus.. 1936, ... 1915, K. Yamagiwa and K. Ichikawa are able to induce cancer in rabbits by applying coal tar to the skin of these laboratory ... 1985, Human Papilloma Viruses 16 and 18 are discovered.. 1986, discovery of Rb anti-oncogene from Retinoblastoma.. 1986, US ... Katsusaburo Yamagiwa and Koichi Ichikawa, in 1915, were able to induce cancer in rabbits by applying coal tar to the skin of ...
Gene profiling of cottontail rabbit papillomavirus-induced carcinomas identifies upregulated genes directly Involved in stroma ...
Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof-of-concept study. Clin ... Evidence of ancient papillomavirus recombination. J Gen Virol 87:2527-31.. *Varsani A, Williamson AL, Jaffer MA, Rybicki EP. ... A novel papillomavirus in Adelie penguin (Pygoscelis adeliae) faeces sampled at the Cape Crozier colony, Antarctica. J Gen ... Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid ...
Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis. ... The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus ... Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3 ... Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular ...
Cottontail rabbit papillomavirus (CRPV) induces papillomas in domestic rabbits which progress at a very high rate to cancer. ... In summary, our analyses confirmed that papillomaviruses have highly similar transcriptional patterns, but they do not suggest ... Persistent infections with high-risk human papillomaviruses (HPVs) can result in the development of cancer of the cervix uteri ... splice junctions 7810/3714 and 1751/3065 in both papillomas and carcinomas which have been described for other papillomaviruses ...
  • Given the literature, the Mexican cottontail was available all year around (Niederberger 1979) and it was the most common animal during prehistoric times for food, and it seems as though the Mexican cottontail rabbit was very abundant. (thefreedictionary.com)
  • Some of the species in question that will get a closer look--and which CBD hopes are "fast-tracked" for protection--include the walrus, the wolverine, the Mexican gray wolf, the New England cottontail rabbit , three species of sage grouse, the scarlet Hawaiian honeycreeper ('I'iwi), the California golden trout, the Rio Grande cutthroat trout and the Miami blue butterfly, among others. (thefreedictionary.com)
  • They monitored the rabbits, and after four weeks, noticed tumors on the animals, which Hu said demonstrated that the virus had traveled through the bloodstream and caused an infection. (psu.edu)
  • Sylvilagus floridanus Papillomavirus (SfPV) causes growth of large horn-like tumors on rabbits. (openrepository.com)
  • Hu noted that this was a significant finding because people with cancer are sometimes found to have papillomavirus sequences in their stomach and other internal organs. (psu.edu)
  • Type-specific papillomavirus DNA sequences and peptides Patent Grant Lancaster , et al. (uspto.report)
  • Papillomavirus has traditionally been considered strictly a sexually transmitted disease, but a recent study found that rabbit and mouse papillomaviruses could be transferred by blood to their respective hosts. (psu.edu)
  • We found 20 of 1395 rabbits in the KU collection SfPV symptomatic. (openrepository.com)