A species of gram-positive, asporogenous bacteria that was originally isolated from necrotic areas in the kidney of a sheep. It may cause ulcerative lymphangitis, abscesses, and other chronic purulent infections in sheep, horses, and other warm-blooded animals. Human disease may form from contact with infected animals.
Infections with bacteria of the genus CORYNEBACTERIUM.
A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.
A human and animal pathogen causing mesenteric lymphadenitis, diarrhea, and bacteremia.
Inflammation of the lymph nodes.
Infections with bacteria of the species YERSINIA PSEUDOTUBERCULOSIS.
Diseases of domestic and mountain sheep of the genus Ovis.
A species of gram-positive, asporogenous, non-pathogenic, soil bacteria that produces GLUTAMIC ACID.
Diseases of the domestic or wild goat of the genus Capra.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
A species of gram-positive, asporogenous bacteria in which three cultural types are recognized. These types (gravis, intermedius, and mitis) were originally given in accordance with the clinical severity of the cases from which the different strains were most frequently isolated. This species is the causative agent of DIPHTHERIA.
An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.
Diseases of domestic and wild horses of the species Equus caballus.
The genetic complement of a BACTERIA as represented in its DNA.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A genus of gram-negative, facultatively anaerobic rod- to coccobacillus-shaped bacteria that occurs in a broad spectrum of habitats.
The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Infections with bacteria of the genus YERSINIA.
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.
An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.

Identification of nonlipophilic corynebacteria isolated from dairy cows with mastitis. (1/64)

Nonlipophilic corynebacteria associated with clinical and subclinical mastitis in dairy cows were found to belong to four species: Corynebacterium amycolatum, Corynebacterium ulcerans, Corynebacterium pseudotuberculosis, and Corynebacterium minutissimum. These species may easily be confused. However, clear-cut differences between C. ulcerans and C. pseudotuberculosis were found in their acid production from maltotriose and ethylene glycol, susceptibility to vibriostatic agent O129, and alkaline phosphatase. Absence of growth at 20 degrees C and lack of alpha-glucosidase and 4MU-alpha-D-glycoside hydrolysis activity differentiated C. amycolatum from C. pseudotuberculosis and C. ulcerans. The mastitis C. pseudotuberculosis strains differed from the biovar equi and ovis reference strains and from caprine field strains in their colony morphologies and in their reduced inhibitory activity on staphylococcal beta-hemolysin. C. amycolatum was the most frequently isolated nonlipophilic corynebacterium.  (+info)

Targeting improves the efficacy of a DNA vaccine against Corynebacterium pseudotuberculosis in sheep. (2/64)

A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (DeltaPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotuberculosis, the causal agent of caseous lymphadenitis in sheep. CTLA-4 binds to B7 on antigen-presenting cells and thus was used to direct the fusion antigens to sites of immune induction. Here we demonstrated that targeting DeltaPLD as a CTLA-4 fusion protein significantly enhanced the speed, magnitude, and longevity of the antibody response compared to that obtained with DNA encoding DeltaPLD. While all groups of sheep vaccinated with DNA encoding DeltaPLD were afforded better protection against an experimental challenge with C. pseudotuberculosis than those immunized with an irrelevant plasmid or those left unimmunized, the best protection was provided by the targeted DNA vaccine. We propose that targeting antigens to antigen-presenting cells offers a generic strategy for enhancing the efficacy of DNA vaccines.  (+info)

Tumor necrosis factor alpha and gamma interferon are required for the development of protective immunity to secondary Corynebacterium pseudotuberculosis infection in mice. (3/64)

The production and role of endogenous cytokines during the course of secondary Corynebacterium (C.) pseudotuberculosis infection were investigated in mice. When immunized mice were challenged on day 28 after primary infection, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were found to appear at 3 hr and to reach the maximum at 24 hr after challenge. Spleen cells of mice primarily infected from 2 to 8 weeks before produced a significant amount of TNF-alpha and IFN-gamma when stimulated with formalin-killed bacteria. However, they could not produce detectable amounts of IL-4. The administration of anti-TNF-alpha monoclonal antibody (MAb) and IFN-gamma MAb increased bacterial proliferation in the organs of immune mice and exacerbated the secondary infection. Injection of anti-CD4 MAb alone or anti-CD4 plus anti-CD8 MAbs resulted in significantly increased mortality and a marked suppression of bacterial elimination as well as cytokine production of secondarily infected mice, while the treatment with anti-CD8 MAb alone showed no effect on either the resistance or cytokine production of mice. These results suggest that CD4, probably Th1 T cells, play an important role for establishment of protective immunity against secondary C. pseudotuberculosis infection by secreting TNF-alpha and IFN-gamma.  (+info)

Characterization of United Kingdom isolates of Corynebacterium pseudotuberculosis using pulsed-field gel electrophoresis. (4/64)

Caseous lymphadenitis is a chronic suppurative disease caused by Corynebacterium pseudotuberculosis and is responsible for serious economic losses to the sheep and goat industry. Caseous lymphadenitis was first reported for goats in the United Kingdom in 1990 and for sheep in 1991. Recent evidence suggests that the prevalence of the disease within the national flock is increasing. Fifty isolates of C. pseudotuberculosis from the United Kingdom comprising sheep and horse isolates, the original goat outbreak strain, and the type strain were characterized by biotyping, antimicrobial susceptibility, production of phospholipase D, and genotyping by pulsed-field gel electrophoresis using SfiI and SmaI. All of the isolates were confirmed as C. pseudotuberculosis, and all produced phospholipase D but none reduced nitrate. Restriction with SfiI generated 16 to 18 bands between 48.5 and 290 kb and differentiated six pulsotypes. We conclude that 80% of the strains tested were epidemiologically related to the outbreak strain and that the equine profile was distinct both phenotypically and genotypically.  (+info)

Mechanism of induction of complement susceptibility of erythrocytes by spider and bacterial sphingomyelinases. (5/64)

We have recently shown that the sphingomyelinase toxins P1 and P2 from the venom of the spider Loxosceles intermedia induce complement (C)-dependent lysis of autologous erythrocytes by induction of the cleavage of cell surface glycophorins through activation of an endogenous metalloproteinase facilitating the activation of the alternative pathway of C. Phospholipase D (PLD) from Corynebacterium pseudotuberculosis shows some degree of homology with the spider sphingomyelinases and can induce similar clinical symptoms to those observed after spider envenomation. The aim of this study was to investigate if the bacterial PLD-induced haemolysis of human erythrocytes was C dependent and if cleavage of glycophorins occurred. We show here that haemolysis of both PLD- and P1-treated human erythrocytes was C dependent, but while PLD-mediated haemolysis was dependent on activation of the classical pathway of C, P1 induced lysis via both the classical and alternative pathways. P1, but not PLD, induced cleavage of glycophorins and no change in expression of complement regulators was induced by either of the toxins. In both cases, annexin V binding sites were exposed, suggesting that the membrane asymmetry had been disturbed causing exposure of phosphatidylserine to the cell surface. Our results suggest that C susceptibility induced by L. intermedia and C. pseudotuberculosis PLD is a result of exposure of phosphatidylserine, and the higher potency of P1 toxin can be explained by its additional effect of cleavage of glycophorins.  (+info)

Ovine mononuclear phagocytes in situ: identification by monoclonal antibodies and involvement in experimental pyogranulomas. (6/64)

In order to characterize in situ the macrophages present in experimental pyogranulomas induced in lambs with Corynebacterium pseudotuberculosis, a set of monoclonal antibodies (MAbs) was produced following immunization of BALB/c mice with alveolar macrophages from healthy sheep. Three MAbs were retained after two steps of screening using alveolar macrophages, peripheral blood lymphocytes, and polymorphonuclear leukocytes as target cells. Their reactivity was tested not only on macrophages in pyogranulomas but also on sections of various organs in steady-state conditions. One MAb, termed OM1, recognized the monocytes and the majority of cells of the mononuclear phagocyte system in lymphoid and nonlymphoid organs. The two other MAbs, OM2 and OM3, reacted with a subpopulation of alveolar macrophages and with other cell types in tissues, in particular with endothelial cells for the MAb OM2. On sections of experimental pyogranulomas that developed in lymph nodes draining the C. pseudotuberculosis-injected sites, MAb OM1 reacted with all the macrophages distributed in a palisade surrounding the necrotic center of the lesion from day 6 to day 28 postinoculation. The two other MAbs, OM2 and OM3, enabled two types of granulomas to be distinguished: one type was characterized by a large number of epithelioid cells stained by OM2; and the other was characterized by a few OM2-positive macrophages, whereas the OM3-positive cells were more numerous. These results show that macrophages are predominant cells in pyogranulomas and suggest two different histological patterns in the evolution of pyogranulomas induced by C. pseudotuberculosis, according to the immunological status of the host.  (+info)

Corynebacterium pseudotuberculosis infection in Israeli dairy cattle. (7/64)

Two forms of Corynebacterium pseudotuberculosis infection in Israeli dairy cattle herds during a survey period of 13 years (1989-2001) are described. The more common form, which was diagnosed in 45 herds, was characterized by ulcerative granulomatous lesions which occurred either sporadically--in 26 herds (with a morbidity rate of up to 5%)--or in an epidemic course in 19 herds. Most (80.6%) of the affected animals were cows; the rest were first-calving cows (16.2%) and heifers (3.2%). The morbidity occurred mostly during the summer months. The ulcerative granulomatous lesions appeared in three clinical forms: cutaneous, mastitic and visceral. Mixed forms were also observed. The morbidity rate was 6.4% and the culling rate reached 16.3% of the affected animals. Most of the strains of C. pseudotuberculosis which were isolated from the abscesses in the cutaneous form of the disease and from milk samples failed to reduce nitrate. A decrease in milk production (6%) and an increase in bulk-milk somatic cell count were noted. Necrotic and ulcerative dermatitis on the heel of the foot occurred in an epidemic course in heifers in only two herds during the winter months, with morbidity rates of 7.5 and 76.2%, respectively. C. pseudotuberculosis isolates from skin lesions and from the soil did reduce nitrate. Clinical, epizootiological and microbiological aspects of the infection are described.  (+info)

Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. (8/64)

The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease. This clearly establishes PLD as a major C. pseudotuberculosis virulence factor. Vaccination of sheep with live Toxminus C. pseudotuberculosis elicits strong humoral and cell-mediated immune responses and protects the animals from wild-type challenge.  (+info)

TY - JOUR. T1 - Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis. AU - Gorman, Jennifer K.. AU - Gabriel, Mourad. AU - Maclachlan, Nigel J. AU - Nieto, Nathan C.. AU - Foley, Janet E. AU - Spier, Sharon. PY - 2010. Y1 - 2010. N2 - This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. Twenty-four BALB/c mice were inoculated with two doses of bacterin-toxoid vaccine or two injections of a placebo. Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. Successful protection via a vaccine against equine internal abscesses might ...
Corynebacterium pseudotuberculosis is a pathogenic bacterium which has been rapidly spreading all over the world, causing economic losses in the agricultural sector and sporadically infecting humans. Six C. pseudotuberculosis strains were isolated from goats, sheep, and horses with distinct abscess locations. For the first time, Mexican genomes of this bacterium were sequenced and studied in silico. All strains were sequenced using Ion Personal Genome Machine sequencer, assembled using Newbler and SPAdes software. The automatic genome annotation was done using the software RAST and in-house scripts for transference, followed by manual curation using Artemis software and BLAST against NCBI and UniProt databases. The six genomes are publicly available in NCBI database. The analysis of nucleotide sequence similarity and the generated phylogenetic tree led to the observation that the Mexican strains are more similar between strains from the same host, but the genetic structure is probably more influenced by
Corynebacterium pseudotuberculosis is a bacterium which causes diseases such as caseous lymphadenitis in small ruminants, resulting in large-scale economic losses for agribusiness worldwide. Consequently, this bacterium including its transcriptional profile analysis has been the focus of various stu Integrative Computational Biology
Background Corynebacterium pseudotuberculosis is classified into two biovars, nitrate-negative biovar Ovis which is the etiologic agent of caseous lymphadenitis in small ruminants and nitrate-positive biovar Equi, which causes abscesses and ulcerative lymphangitis in equines. The aim of this study was to develop a quadruplex PCR assay that would allow simultaneous detection and biovar-typing of C. pseudotuberculosis. Methods In the present study, genomes of C. pseudotuberculosis strains were used to identify the genes involved in the nitrate reduction pathway to improve a species identification three-primer multiplex PCR assay. The nitrate reductase gene (narG) was included in the PCR assay along with the 16S, rpoB and pld genes to enhance the diagnosis of the multiplex PCR at biovar level. Results A novel quadruplex PCR assay for C. pseudotuberculosis species and biovar identification was developed. The results of the quadruplex PCR of 348 strains, 346 previously well-characterized clinical ...
Heat shock proteins (HSPs) are important candidates for the development of vaccines because they are usually able to promote both humoral and cellular immune responses in mammals. We identified and characterized the hsp60-hsp10 bicistronic operon of the animal pathogen Corynebacterium pseudotuberculosis, a Gram-positive bacterium of the class Actinobacteria, which causes caseous lymphadenitis (CLA) in small ruminants. To construct the DNA vaccine, the hsp60 gene of C. pseudotuberculosis was cloned in a mammalian expression vector. BALB/c mice were immunized by intramuscular injection with the recombinant plasmid (pVAX1/hsp60). This vaccination induced significant anti-hsp60 IgG, IgG1 and IgG2a isotype production. However, immunization with this DNA vaccine did not confer protective immunity.
Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. To investigate proteins that could be related to the virulence of this pathogen, we combined an experimental passage process using a murine model and high-throughput proteomics with a mass spectrometry, data-independent acquisition (LC-MSE) approach to identify and quantify the proteins released into the supernatants of strain 258_equi. To our knowledge, this approach allowed characterization of the exoproteome of a C. pseudotuberculosis equi strain for the first time. Interestingly, the recovery of this strain from infected mouse spleens induced a change in its virulence potential, and it became more virulent in a second infection challenge. Proteomic screening performed from culture supernatant of the control and recovered conditions revealed 104 proteins that were differentially expressed between the two conditions. In this context, proteomic analysis of the recovered condition detected the induction of
TY - CONF. T1 - Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates. AU - Magalhães, T.. AU - Oliveira, M.. AU - Nunes, S. F.. AU - Carneiro, C.. AU - Cavaco, Lina. AU - Vilela, C. L.. N1 - Conference code: 2. PY - 2006. Y1 - 2006. M3 - Poster. T2 - 2nd FEMS Congress of European Microbiologists. Y2 - 4 July 2006 through 8 July 2006. ER - ...
The results of ROC analysis indicated that the IgG isotype ELISA was more accurate than the total antibody ELISA. The efficiency of the test was greatest when serum samples were run in a dilution series than when any single serum dilution was used. The ELISA is considered to be suitable for application in field studies of CLA in UK sheep.. ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar ...
A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebocterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred. At subsequent necropsy, typical CLA lesions were seen in 133 sheep, and the diagnosis was confirmed on culture. Lesions were most commonly seen in lungs (n = 46), parotid lymph nodes (n = 44), prescapular lymph nodes (n = 38) and mediastinal lymph nodes (n = 31). The sensitivity of the ELISA test for detecting culture-positive sheep was 0.88, while the specificity of the test was 0.55. The antibody ELISA detected 87.5 per cent of sheep that had CLA lesions restricted to internal organs only. It was concluded that the ELISA test has a valuable role in detecting sheep with both clinical and subclinical CLA.. ...
Abstract: Goat farming in the northeastern regions of Brazil plays an important role in the socio-economic functions of the country. However, high rates of morbidity and mortality occur in the animals, caused primarily by infectious diseases like caseous lymphadenitis, which is widespread in goat herds; this causes serious economic losses to the farming business. Although events such as animal fairs are common in the region, wherein most of the goats and sheep are sold, the risk of disease transmission remains, since the health condition of the animal is unknown. The aim of this study was to determine the frequency of anti-Corynebacterium pseudotuberculosis antibodies present in the goats sold at the animal fair of Tabira - PE, Northeastern semi-arid. Serum samples from 233 goats were collected from the period of November 2014 to June 2015. The diagnosis of infection by C. pseudotuberculosis was made using the indirect ELISA technique. The number of goats seropositive for C. pseudotuberculosis ...
Corynebacterium pseudotuberculosis is a Gram-positive bacterium that belongs to the class Actinobacteria. This bacterium is a facultative intracellular pathogen that causes the disease caseous lymphadenitis (CL) in sheep and goats. During the process of infection by these bacteria are contained cells of the innate immune response, among which the main effectors defensives cells are neutrophils and macrophages. This work has been proposed with the aim of assessing the response of murine bone marrow monocyte-derived macrophages in in vitro infection with the CP13 strain of C. pseudotuberculosis - a knockout mutant for a gene related to the transportation of iron in Corynebacterium diphtheriae that generated good levels of protection against subsequent infections C. pseudotuberculosis - and observe the response profile generated by these cultures. This type of characterization allows the inference of the involvement of innate immune response against infections caused by this bacterium. So far, it ...
General Information: Strain FRC41 was isolated from the inguinal lymph node of a 12-year-old girl in France with necrotizing lymphadenitis. Corynebacterium pseudotuberculosis, an important animal pathogen, is the etiological agent of a disease that is commonly called caseous lymphadenitis (CLA) or cheesy gland. This disease is found in all the worlds major sheep and goat production areas, causing significant economic losses worldwide, mainly due to the reduction of wool, meat and milk yields, decreased reproductive efficiencies of affected animals and condemnation of carcasses and skins in abattoirs. In some cases, the infection produces few obvious clinical signs in the animal, remaining unrecognized until a post-mortem examination has been carried out and, making it difficult to obtain definitive data about prevalence of the disease. ...
Corynebacterium pseudotuberculosis is a facultative intracellular pathogen with pleomorphic forms. While two forms of the bacteria exist, in our study, we are most concerned with the equi biovar, the strain that affects horses and cattle. The major secreted exotoxin is phospholipase D (PLD), which catalyzes the hydrolysis of ester bonds in phospholipids. Management of the disease is highly challenging, as antibiotics are often ineffective since bacteria stay protected inside abscesses within thick enclosing capsules. This leads to the overarching goal of the study: the development of a vaccine against C. pseudotuberculosis . Since the disease can manifest either internally or externally, further understanding of the roles of the antibody and cell-mediated responses in determining the form of disease is crucial. Important stepping-stones for success include the establishment of the roles TH1 and TH2 lymphocytes in response to the bacteria and the comparison of antibody responses in different ...
There have been several reports of pigeon fever in the region. With this in mind, here are some facts about this condition in horses, including information about recognition, prevention, and treatment.. Pigeon fever got its name because the most common form of the disease involves swelling and abscessation of the pectoral region, which resembles a pigeons breast. The disease is not caused or carried by birds, but instead is the result of infection with a bacterium called Corynebacterium pseudotuberculosis. This pathogen can also affect other animals, including sheep and cattle, but the syndrome in horses is fairly unique to this species. It is most common in arid climates, but can definitely be found in Missouri and all throughout the United States, and its prevalence is increasing.. There are three forms of pigeon fever. The first is the most classic-the aforementioned abscesses in the chest (and potentially elsewhere on the body). While this can be painful and unsightly, most horses make a ...
Pigeon fever is an infection caused by the bacteria Corynebacterium pseudotuberculosis. This causes large abscesses on the chest or under the belly ...
External lumps and bumps in dairy goats have many causes, but most owners assume that all lumps are abscesses and that all abscesses are caused by Corynebacterium. Although Corynebacterium is a significant cause of external masses in goats, one should not assume that all lumps are abscesses or that all external masses occurring in a herd result from the same cause. Determining the correct origin of an external mass requires a detailed history, a thorough physical examination and aspiration or biopsy. Once a diagnosis has been made, an appropriate therapy can be chosen and a prognosis for recovery can be determined.. Abscesses caused by a wide variety of bacteria are the most common cause of external masses in dairy goats. Numerous bacteria live on the surface of healthy skin and mucous membranes and can be introduced into body tissues through small ulcers and puncture wounds. Coarse hay, grass awns, wood splinters, unsanitary injection needles and accidental trauma can introduce bacteria into ...
Risks for Caseous lymphadenitis , Caseous lymphadenitis treatments, recommended products for Caseous lymphadenitis , ways to prevent Caseous lymphadenitis , causes of Caseous lymphadenitis
Antisera against Actinobacillus seminis, Brucella ovis and Corynebacterium pseudotuberculosis were prepared in adult female goats. Specific immunofluorescence was observed in cultural smears of A seminis, B ovis and C pseudotuberculosis by the direct technique and in smears of A seminis also by the indirect technique. Individual organisms could be recognised. Specific fluorescence of A seminis was readily detected in semen. The results indicate that immunofluorescence may offer an effective method for rapidly and accurately diagnosing bacterial epididymitis in sheep, especially before epididymal lesions are palpable.. ...
Equine lymphangitis is an inflammation or swelling associated with impairment of the lymphatic system, particularly in a limb, in horses. It is most commonly a bacterial infection, although bacterial culture may be negative. Often referred to as fat/big leg disease, it is sometimes known as weed or Monday morning disease (not to be confused with the more common usage of MMD referring to exertional rhabdomyolysis or azoturia). This article refers mainly to sporadic lymphangitis. Ulcerative lymphangitis is referred to in passing, as it is managed in a similar manner. Epizootic lymphangitis is similar to glanders, but caused by the fungus Histoplasma farciminosum. Corynebacterium pseudotuberculosis has been cultured from some cases (particularly of ulcerative lymphangitis; however, in others, bacterial culture is negative. This may be because: a) The micro-organism responsible is difficult to culture (e.g. many Mycoplasma species). b) The organism has been effectively eliminated by the immune ...
When treating CLA *never burst the abscess to expel the fluid inside* this can be an extremely quick way of spreading the disease to others and to progressing the sheep to a visceral form of the disease. If it is necessary, shave the area round the abscess, isolate the sheep, make a small incision I the abscess, drain it fully, apply disinfectant to the area around it and thoroughly clean the area afterwards where the sheep has been penned. Never leave the fluid that is expelled on the floor or near water troughs or food sources. ...
Clinical signs include changes to the mucus membranes around the mouth, nose and coronary band of the foot. Generally the signs are more severe in sheep, than cattle. Symptoms notifiable are large numbers of sheep with lameness, high rectal temperatures, salivation, and lacrimation, ocular and nasal discharge. Incubation period of the virus is 4-12 days, followed by a fever (42 degrees C) and appear stiff or reluctant to move. Adopt arched back stance, neck extended, head lowered. Swelling on the face and ears, along with pulmonary oedema, sometimes causing breathing difficulties. Erosions may appear on lips, turning to ulcers. Profuse salivation and serous to mucopurulent nasal discharge. Reddening of the coronary band, and around the muzzle and mouth. Tongue may be swollen ...
24 May 2002 Shearing risks spreading CLACARE at shearing will help limit spread of sheep disease, caseous lymphadenitis. But development of a new blood tes
Abstract:. Veterinary inspection in abattoirs is extremely important either economic or public health point of view because a great amount of visceras are rejected in order to maintain a low risk for human. However, due to work dynamics in slaughterhouses, it is usually difficult to uncover this etiology. In this study, we applied simple protocols to determine the final diagnosis and the etiology of such rejections. Over the course of a year, organs rejected during meat inspection were sampled from an ovine slaughterhouse in central Spain that slaughtered both sheep and lambs. The application of these protocols were very useful in the identification of bacterial agents involved in those rejections that clinically were compatible with enzootic pneumonia and caseous lymphadenitis as well as abscesses, among others. The regular application of these protocols would provide valuable information to establish control measures of those processes that reach to the slaughterhouses and in consequence to ...
This case report describes a Yersinia pseudotuberculosis infection in an adult, female single pet goat kept on a dairy cattle farm. The doe showed the habitus of a chronically ill animal, with poor body condition and chronic diarrhoea, when presented at the clinic. The animal displayed a grave manifestation of the disease with severe enteritis and typhlocolitis, lymphadenitis and some up to 10 cm in diameter pyogranulomatous inflammation in the liver, spleen, pancreas, omasum and the intestinal lymph nodes. All other causative agents that might explain the described signs were ruled out (Corynebacterium pseudotuberculosis, Mycobacterium avium subspecies paratuberculosis, tuberculosis, tumorous alterations, foreign bodies, caprine arthritis encephalitis). Goats seem to be vulnerable for yersiniosis, but in contrast to this case report, in most cases, Yersinia enterocolitica, and not Y. pseudotuberculosis, can be proved as infectious cause of yersiniosis. ...
Goat farming in the Northeast region of Brazil plays an important socioeconomic and strategic role. The rusticity of this activity in this region, allied with its rapid expansion in other states, has caused losses in its production chain in regional and national levels, caused by infectious diseases, especially caseous lymphadenitis (CL), a widespread goat herds disease which has been causing serious economic loss to this activity. Although CL has been detected as an endemic problem in the Brazilian Northeast, a comprehensive and more recent analysis of this prevalence in Brazilian goats is necessary. The objective of this study was to determine the frequency of anti-Corynebacterium pseudotuberculosis antibodies in five of nine states of the northeast region of Brazil. Serum samples were collected from 2571 goats from 218 farms in five states in the Northeast region of Brazil, collected between 2010 and 2012. The diagnosis of C. pseudotuberculosis infection was made using the ELISA-indirect ...
Y. pseudotuberculosis is considered primarily an extracellular pathogen, and the plasmid-encoded T3SS has been studied largely with respect to its role in promoting the extracellular phase of Y. pseudotuberculosis pathogenesis (50). However, an early intracellular stage may be important for Y. pseudotuberculosis pathogenesis (14, 35, 47). Our results confirmed that phagocytosis inhibition by Yops is not complete (15, 36), as roughly 40% of the wild-type bacteria that came in contact with macrophages were taken up (Fig. 1). We found that the presence of a fully functional T3SS strongly restricted the intracellular survival of the bacteria, as only a small percentage of the pYV+ wild-type Y. pseudotuberculosis internalized under these conditions survived and replicated. Although the presence of the T3SS appeared to restrict the intracellular survival of the bacteria, it also allowed the bacteria to translocate YopJ and induce macrophages to undergo apoptosis. These findings expand our ...
Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyers patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. pseudotuberculosis gave rise to asymptomatic persistent infection in mice and identified the cecal lymphoid follicles as the primary site for colonization during persistence. Persistent Y. pseudotuberculosis is localized in the dome area, often in inflammatory lesions, as foci or as single cells, and also in neutrophil exudates in the cecal lumen. This new mouse model for bacterial persistence in cecum has potential as an investigative tool for deeper understanding of bacterial adaptation and host immune defense mechanisms during persistent infection. Here, we investigated the nature of the persistent infection established by Y. pseudotuberculosis in mouse cecal tissue using in vivo RNA-seq of bacteria during early ...
Pseudotuberculosis definition, an acute, sometimes fatal disease of rodents, birds, and other animals, including humans, caused by the bacterium Yersinia (Pasteurella) pseudotuberculosis, and characterized by the formation of nodules resembling those that result from tuberculosis. See more.
Acinetobacter baumannii Actinobacillus pleuropneumoniae Anaplasma phagocytophilum Bacillus anthracis Bacillus cereus Bartonella henselae Bartonella quintana Bordetella bronchiseptica Bordetella pertussis Borrelia burgdorferi Brucella abortus Brucella canis Burkholderia pseudomallei Campylobacter jejuni Capnocytophaga canimorsus Chlamydia pneumoniae Chlamydia trachomatis Chlamydophila psittaci Clostridium botulinum Clostridium tetani Clostridium perfringens Corynebacterium pseudotuberculosis Coxiella burnetii Cronobacter sakazakii Francisella tularensis Haemophilus influenzae Haemophilus parasuis Helicobacter pylori…
Yersinia pseudotuberculosis is a Gram-negative bacterium that causes Far East scarlet-like fever in humans, who occasionally get infected zoonotically, most often through the food-borne route. Animals are also infected by Y. pseudotuberculosis. The bacterium is urease positive. In animals, Y. pseudotuberculosis can cause tuberculosis-like symptoms, including localized tissue necrosis and granulomas in the spleen, liver, and lymph nodes. In humans, symptoms of Far East scarlet-like fever are similar to those of infection with Yersinia enterocolitica (fever and right-sided abdominal pain), except that the diarrheal component is often absent, which sometimes makes the resulting condition difficult to diagnose. Y. pseudotuberculosis infections can mimic appendicitis, especially in children and younger adults, and, in rare cases, the disease may cause skin complaints (erythema nodosum), joint stiffness and pain (reactive arthritis), or spread of bacteria to the blood (bacteremia). Far East ...
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
Pierce, chase C.; Fauve, R M.; and Dubos, R, Corynebacterial pseudotuberculosis in mice. I. Comparative susceptibility of mouse strains to experimental infection with coryne- bacterium kutscheri. (1964). Subject Strain Bibliography 1964. 1371 ...
Yersinia pseudotuberculosis ATCC ® 13979D-5™ Designation: Genomic DNA from NCTC 8580 (ATCC 13979) TypeStrain=False Application:
Yersinia pseudotuberculosis strain IP 31758. This strain is serotype 1b and was isolated in 1966 from the stools of a patient presenting with scarlet-like fever in the Primorski region of the former USSR. The strain was sent to the Institut Pasteur by Dr. Timofeeva (Antiplague Institute, Irkoutsk).Two libraries were constructed: a small insert library (4-5 kb) and a large insert library (10-12 kb) from which 11,818 and 49,665 reads were sequenced respectively. (NCBI BioProject: bp_list[1 ...
Yersinia pseudotuberculosis is a soil- and water-borne enteropathogen. Numerous species are potential carriers of Y.pseudotuberculosis. The asymptomatic carriage can evolve into a fatal infection when the animals are stressed. In Human, different degrees of illness are observed, from fever and abdominal pain to septicemia.(From http://www.expasy.org/sprot/hamap/YERPS.html) (BacMap ...
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other. ...
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
This is Sweetie. Shes a Pygmy goat. One of Moms friends rescued Sweetie, but now Sweetie needs a home so shes come to live with us on our farm.. Some people Moms friend knows bought Sweetie at a sheep and goat auction at a place called a sale barn. People bring their animals to sale barns to sell them fast, but theyre not good places to buy. Animals sold at sale barns are often sick or theres something wrong with them. Its better to buy livestock from individuals or breeders. Heres why:. Even if an animal isnt sick before its sold through a sale barn, its exposed to disease on sale day. Some serious diseases you can bring home are strangles and flu in horses; hoof rot in cloven-hoofed animals; an incurable abscess-causing disease called caseous lymphadenitis in sheep and goats; and respiratory disease in livestock of all kinds.. In addition to sick animals, some people take other kinds of problem animals to sale barns to sell to unsuspecting buyers. Theyll sell sows that never get ...
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
A 10 months old girl presented with left sided axillary lymphadenitis. There is no other lymphnode enlargement. Chest is clear and there is no fever.
This post explores the Corynebacterium, a large group of mostly harmless bacteria that holds some surprises. Included is a demonstrated means of removal.
void:inDataset: http://aims.fao.org/aos/agrovoc/void.ttl#Agrovoc. Created: 2011-11-20T20:02:53Z. Last modified: 2011-11-20T20:02:53Z. skos:notation: 1913 ...
Three coryneform strains isolated from clinical samples were analysed. These strains fitted the biochemical profile of Corynebacterium striatum by conventional methods. However, according to recently described identification tests for fermenting corynebacteria, the strains behaved rather like Corynebacterium minutissimum. The three isolates could be distinguished from C. minutissimum by a positive nitrate and nitrite reductase test and by not fermenting maltose; from C. striatum by their inability to acidify ethylene glycol and to grow at 20 degrees C. Genetic studies based on 16S rRNA showed that the three strains were in fact different from C. minutissimum and C. striatum (96.9 and 98% similarity, respectively) and from other corynebacteria. They represent a new species for which the name Corynebacterium simulans sp. nov. is proposed. The type strain is DSM 44415T (= UCL 553T = Co 553T).
Some species of Corynebacterium have sequenced genomes that range in size from 2.5 - 3 Mbp. They can be found in many environments including soil, trees and skin. The non-diptheiroid Corynebecterium can also be found in human mucous membranes. They grow slowly, even on enriched media, and undergo Chinese Letter division. Species of Corynebacterium have been used in the mass production of various amino acids including L-Glutamic Acid, a popular food additive that is made at a rate of 1.5 million tons/ year by Corynebacterium. The metabolic pathways of Corynebacterium have been further manipulated to produce L-Lysine and L-Threonine ...
BALLYA test for tulathromycin used for detection tulathromycin residues in feed and food. Just only 15 minutes to result. Rapid test manufacturer directly supply. Low cost, worldwide shipping. BALLYA Tulathromycin test kit wholesale.
Dear collegues, I´d like to get to know people (scientists, work groups et c.), who work on any topic concerning the genera Corynebacterium or Brevibacterium. As I started my PhD studying Corynebacterium glutamicum (osmotic stress - amino acid production) last year I would be grateful to get in contact with as many people as possible sharing interest in this field of research. However, please don´t hesitate to contact me, if you´re working on the molecular biology level. My aim is to get to know problems you don´t read from in the literature or even share some problem solutions.... Thank you. If reply, please remove the nospam Yours, Hendrik Rönsch University of Cologne, Biochemistry Please visit my homepage: http://come.to/hendrik.roensch ...
This is the business view business. Lymphadenitis is swollen lymph nodes because of inflammation, usually occur as a result of exposure to a bacteria or virus. Less commonly, swollen lymph nodes are caused by cancer. Common areas where you might notice swollen lymph nodes include your neck...
Lymphadenitis is the inflammation or enlargement of a lymph node. Lymph nodes are small, ovoid nodules normally ranging in size from a few millimeters to 2 cm.
Lymphadenitis is the inflammation or enlargement of a lymph node. Lymph nodes are small, ovoid nodules normally ranging in size from a few millimeters to 2 cm.
Corynebacterium pseudotuberculosis has also been isolated from occurring in other species such as such as deer, cattle, pigs, ... The biotype of Corynebacterium pseudotuberculosis affecting horses and cattle is distinguishable from the biotype that infects ... Baird, G.J.; Fontaine, M.C. (2007). "Corynebacterium pseudotuberculosis and its Role in Ovine Caseous Lymphadenitis". Journal ... Caseous lymphadenitis is an infectious disease caused by the bacterium Corynebacterium pseudotuberculosis, that affects the ...
Corbeil, LE; Morrissey, JF; Léguillette, R (October 2016). "Is Corynebacterium pseudotuberculosis infection (pigeon fever) in ... "Frequency of Corynebacterium pseudotuberculosis infection in horses across the United States during a 10-year period". Journal ... "Experimental transmission of Corynebacterium pseudotuberculosis biovar equi in horses by house flies". Journal of Veterinary ... caused by the Gram-positive bacteria Corynebacterium pseudotuberculosis biovar equi. Infected horses commonly have swelling in ...
Corynebacterium pseudotuberculosis has been cultured from some cases (particularly of ulcerative lymphangitis; however, in ... However, intracellular organisms such as Corynebacterium pseudotuberculosis will be susceptible to certain antibiotics in vitro ...
Corynebacterium pseudo tuberculosis I19 as a case study. Journal of Microbiological Methods, 86(2), 218-223. doi: 10.1016/j. ... pseudotuberculosis was assembled twice: once using a classical reference genome approach, and once using a hybrid approach. The ...
Corynebacterium ulcerans Coxiella burnetii or Q fever Plesiomonas shigelloides In addition to disease caused by direct ... including O1 and non-O1 Vibrio parahaemolyticus Vibrio vulnificus Yersinia enterocolitica and Yersinia pseudotuberculosis Less ...
Corynebacterium pseudotuberculosis (causative agent of pigeon fever), equine influenza virus, or equine herpes virus type 1, or ...
Corynebacterium pseudotuberculosis MeSH B03.510.024.049.180.625 - Corynebacterium pyogenes MeSH B03.510.024.049.250 - Frankia ... Corynebacterium glutamicum MeSH B03.510.460.400.400.200.600 - Corynebacterium pseudotuberculosis MeSH B03.510.460.400.400.200. ... Corynebacterium MeSH B03.510.024.049.180.100 - Brevibacterium flavum MeSH B03.510.024.049.180.150 - Corynebacterium diphtheriae ... Corynebacterium MeSH B03.510.460.400.400.200.150 - Corynebacterium diphtheriae MeSH B03.510.460.400.400.200.300 - ...
Several species cause disease in animals, most notably C. pseudotuberculosis, which causes the disease caseous lymphadenitis, ... afermentans Corynebacterium auris Corynebacterium pseudodiphtheriticum Corynebacterium propinquum Corynebacterium uropygiale ... Corynebacterium xerosis and Corynebacterium striatum Corynebacterium minutissimum Corynebacterium amycolatum Corynebacterium ... lipophilum Corynebacterium accolens Corynebacterium macginleyi CDC coryneform groups F-1 and G Corynebacterium bovis ...
... is a gram-positive bacterium known globally to infect ruminants, horses and, rarely, people ... Corynebacterium pseudotuberculosis can also cause disease in horses. Infected horses also present with abscessation, however ... "Corynebacterium pseudotuberculosis Infection of Horses and Cattle - Circulatory System". Merck Veterinary Manual. Retrieved ... Baird, G.J.; Fontaine, M.C. (2007). "Corynebacterium pseudotuberculosis and its Role in Ovine Caseous Lymphadenitis". Journal ...
Corynebacterium ulcerans e Corynebacterium pseudotuberculosis que son tanben la causa d'unas formas de difteria[17] d'origina ... C. pseudotuberculosis provòca tanben una zoonòsi, transmesa per las cabras[18]. Epidemiologia[modificar , modificar la font]. ... La difteria es causada per de socas toxigènas du bacil Corynebacterium diphtheriae de biotipes gravis, mitis o intermedius. La ... Toxigenic Corynebacterium ulcerans in a fatal human case and her feline contacts, France, March 2014. », Eurosurveillance,‎ 11 ...
Clostridium tetani Corynebacterium Corynebacterium diphtheriae Corynebacterium fusiforme Coxiella burnetii Ehrlichia ... parahaemolyticus Vibrio vulnificus Wolbachia Yersinia Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis List ...
... corynebacterium infections MeSH C01.252.410.040.246.388 - diphtheria MeSH C01.252.410.040.246.430 - erythrasma MeSH C01.252. ... yersinia pseudotuberculosis infections MeSH C01.252.400.349 - flavobacteriaceae infections MeSH C01.252.400.368 - ...
2005). "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid- ... 2004). "Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis". Proc ... 2003). "The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129". Nucleic Acids Res. 31 (22): 6516- ... complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium ...
Traditionally, gonorrhea was diagnosed with Gram stain and culture; however, newer polymerase chain reaction (PCR)-based testing methods are becoming more common.[16][28] In those failing initial treatment, culture should be done to determine sensitivity to antibiotics.[29] Tests that use polymerase chain reaction (PCR, aka nucleic acid amplification) to identify genes unique to N. gonorrhoeae are recommended for screening and diagnosis of gonorrhea infection. These PCR-based tests require a sample of urine, urethral swabs, or cervical/vaginal swabs. Culture (growing colonies of bacteria in order to isolate and identify them) and Gram-stain (staining of bacterial cell walls to reveal morphology) can also be used to detect the presence of N. gonorrhoeae in all specimen types except urine.[30][31] If Gram-negative, oxidase-positive diplococci are visualized on direct Gram stain of urethral pus (male genital infection), no further testing is needed to establish the diagnosis of gonorrhea ...
Yersinia pseudotuberculosis infection Yersinia pseudotuberculosis Yersiniosis Yersinia enterocolitica Yellow fever Yellow fever ... Corynebacterium diphtheriae Diphyllobothriasis Diphyllobothrium Dracunculiasis Dracunculus medinensis Ebola hemorrhagic fever ...
Corynebacterium diphtheriae *Diphtheria. *Corynebacterium minutissimum *Erythrasma. *Corynebacterium jeikeium *Group JK ...
Ionfhabhtú Yersinia pseudotuberculosis. Yersinia pseudotuberculosis. Yersiniosis. Yersinia enterocolitica. Yellow fever. Yellow ... Corynebacterium diphtheriae. Diphyllobothriasis. Diphyllobothrium. Dracunculiasis. Dracunculus medinensis. Ebola hemorrhagic ...
Corynebacterium pseudotuberculosis is a gram-positive bacterium known globally to infect ruminants, horses and, rarely, people ... Corynebacterium pseudotuberculosis can also cause disease in horses. Infected horses also present with abscessation, however ... "Corynebacterium pseudotuberculosis Infection of Horses and Cattle - Circulatory System". Merck Veterinary Manual. Retrieved ... Baird, G.J.; Fontaine, M.C. (2007). "Corynebacterium pseudotuberculosis and its Role in Ovine Caseous Lymphadenitis". Journal ...
Organism: CORYNEBACTERIUM PSEUDOTUBERCULOSIS 1002 If you have problems or comments... Back to PBIL home page ... Organism: CORYNEBACTERIUM PSEUDOTUBERCULOSIS 1002 15. CORP1_1_PE1010 RecName: Full=Pup--protein ligase; EC=6.3.2 n2;AltName: ... Organism: CORYNEBACTERIUM PSEUDOTUBERCULOSIS 1002 8. CORP1_1_PE1004 SubName: Full=Xaa-Pro amino peptidase; (CORP1_1.PE1004). ... Organism: CORYNEBACTERIUM PSEUDOTUBERCULOSIS 1002 10. CORP1_1_PE1006 SubName: Full=Sec-in dependent twin-arginine translocase ...
Glycolysis / Gluconeogenesis - Corynebacterium pseudotuberculosis 267 [ Pathway menu , Organism menu , Pathway entry , Download ...
Sulfur metabolism - Corynebacterium pseudotuberculosis Cp162 [ Pathway menu , Organism menu , Pathway entry , Download KGML , ...
... Kate L. Hepworth-Warren,1 Beatrice T ... Corynebacterium pseudotuberculosis biovar equi is the causative agent of "pigeon fever," or "dryland distemper" in horses. The ...
Information about Corynebacterium pseudotuberculosis infection (pigeon fever); signs, diagnosis, treatment options, and ... Corynebacterium pseudotuberculosis is a soil-borne anaerobic bacterium. has a thick lipid coat that lies outside its cell wall ... In horses Corynebacterium pseudotuberculosis causes infection of lower limbs, internal organs (lungs, liver, and kidneys), ... 6,7In the southwestern USA, Corynebacterium pseudotuberculosis infection is seasonal which peaks in the summer and fall. 1 ...
Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that ... Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis PLoS One. 2018 Nov ... Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that ... Corynebacterium pseudotuberculosis* / metabolism * Corynebacterium pseudotuberculosis* / pathogenicity * Drug Resistance, ...
The chromosomal gene encoding the phospholipase D from Corynebacterium pseudotuberculosis (biovar ovis) isolate Whetten 1 was ... Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis Mol ... The chromosomal gene encoding the phospholipase D from Corynebacterium pseudotuberculosis (biovar ovis) isolate Whetten 1 was ... Our results confirm that phospholipase D is a virulence determinant of C. pseudotuberculosis that increases the persistence and ...
Corynebacterium pseudotuberculosis is a bacterium which causes diseases such as caseous lymphadenitis in small ruminants, ... The core stimulon of Corynebacterium pseudotuberculosis strain 1002 identified using ab initio methodologies A. C. Pinto, R. T ... Corynebacterium pseudotuberculosis is a bacterium which causes diseases such as caseous lymphadenitis in small ruminants, ... We sequenced the cDNA of Corynebacterium pseudotuberculosis strain 1002, using the SOLiD V3 system, under the following ...
But this very interesting article from Israel describes a corynebacterium pseudotuberculosis outbreak in a dairy cattle herd ... Mastitis is a well-known sign for a corynebacterium pseudotuberculosis infection. ... CORYNEBACTERIUM PSEUDOTUBERCULOSIS OUTBREAK CAUSES SKIN LESIONS AND MASTITIS Mastitis is a well-known sign for a ... But this very interesting article from Israel describes a corynebacterium pseudotuberculosis outbreak in a dairy cattle herd ...
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a debilitating chronic disease of sheep and ... Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a debilitating chronic disease of sheep and ... Baird, G. J., and Fontaine, M. C. (2007).Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. ... Dorella, F. A., Pacheco, L. G. C., Oliveira, S. C., Miyoshi, A., and Azevedo, V. (2006). Corynebacterium pseudotuberculosis: ...
To our knowledge, this approach allowed characterization of the exoproteome of a C. pseudotuberculosis equi strain for the ... To our knowledge, this approach allowed characterization of the exoproteome of a C. pseudotuberculosis equi strain for the ... Moreover, this study enhances our understanding of the factors that may influence the pathogenesis of C. pseudotuberculosis. ... pseudotuberculosis. Collectively, bacterial pathogenesis-related proteins were identified that contribute to the processes of ...
Corynebacterium pseudotuberculosis (Cp) is the causative agent of caseous lymphadenitis (CLA), a chronic bacterial disease of ... Corynebacterium pseudotuberculosis (Cp) is the causative agent of caseous lymphadenitis (CLA), a chronic bacterial disease of ... Cell invasion and intracellular survival of corynebacterium pseudotuberculosis. 2011, University of Zurich, Vetsuisse Faculty. ...
Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates. T. Magalhães, M. Oliveira, S. F. ... title = "Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates",. author = "T. Magalh{\~a} ... Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates. / Magalhães, T.; Oliveira, M.; ... Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates. 2006. Poster session presented at ...
Serological and allergic study of the course of experimental Corynebacterium pseudotuberculosis infection in goats ... Corynebacterium pseudotuberculosis infection in goats. IV. Course of the infection in two recently infected goat herds. Acta ... Corynebacterium pseudotuberculosis infection in goats in Norway, with special reference to diagnosis, natural and experimental ... Experimental Corynebacterium pseudotuberculosis primary infection in goats: kinetics of IgG and interferon-gamma production, ...
In this work, we present the resequencing of Corynebacterium pseudotuberculosis strain 1002 (Cp1002). Cp1002 was the first ... The new assembly of C. pseudotuberculosis was deposited in GenBank under the accession no. CP012837. ... Studies have detected mis-assemblies in genomes of the species Corynebacterium pseudotuberculosis. These new discover have been ... Corynebacterium pseudotuberculosis strain 1002 (first assembly). Cp1002B: Corynebacterium pseudotuberculosis strain 1002 (new ...
This work represents the first report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black ... To our knowledge, this is the first characterization of C. pseudotuberculosis from caseous lymphadenitis lesions in Black ... Furthermore, swine isolates were compared with C. pseudotuberculosis from caprines and PFGE patterns also showed high ... Macrorestriction patterns obtained by Pulsed Field Gel Electrophoresis (PFGE) grouped the C. pseudotuberculosis in two clusters ...
There is paucity of information on the proinflammatory cytokine (IL-1β and IL-6) responses due to C. pseudotuberculosis and ... The concentration of IL-6 was significantly increased (p,0.05) in weeks five, six, seven and eight in C. pseudotuberculosis ... Group C was inoculated with 2 mL 1×109 colony forming unit (cfu) of live C. pseudotuberculosis intradermally. Blood was ... Therefore, this study was conducted to evaluate the immunogenicity of C. pseudotuberculosis and MAs. Twelve clinically healthy ...
... pseudotuberculosis over a 60-day course of infection. CBA mice (n = 25) were divided into three groups and infected with 102 ... pseudotuberculosis are important regulators of cellular response. Additionally, the lack of the MAPK p38 and ERK 1/2 pathways ... is a contagious infectious disease of small ruminants caused by Corynebacterium pseudotuberculosis. Is characterized by the ... MAPK involvement in cytokine production in response to Corynebacterium pseudotuberculosis infection. *Andréia Pacheco de Souza ...
A total of 2,621 flies of various species were tested for the PLD gene of C. pseudotuberculosis. RESULTS Evidence of bacterial ... CONCLUSIONS AND CLINICAL RELEVANCE Our results are consistent with the hypothesis that C. pseudotuberculosis may be vectored to ... Flies were collected monthly (May to November 2002) from 5 farms in northern California where C. pseudotuberculosis infection ... exotoxin gene of Corynebacterium pseudotuberculosis in an attempt to identify insect vectors that may be important in ...
Corynebacterium pseudotuberculosis biovar ovis. T1 (virulent strain isolates from goats; obtained from the Universidade Federal ... Corynebacterium pseudotuberculosis biovar ovis strain T1 was aerobically grown in brain heart infusion broth (BHI, Acumedia ... Corynebacterium pseudotuberculosis is a facultative, intracellular, Gram-positive bacterium of the class Actinobacteria, which ... Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis (CLA), or cheesy gland, which affects ...
The ERIC 1 + 2 Minimum-spanning tree from 367 strains of C. pseudotuberculosis showed that the great majority of biovar Ovis ... pseudotuberculosis. Taken together the results suggest that biovar Equi is forming the biovar Ovis. However, additional ... pseudotuberculosis belonging to both biovars Ovis and Equi. Additionally, conserved point mutation based on structural ... Corynebacterium pseudotuberculosis can be classified into two biovars or biovars based on their nitrate-reducing ability. ...
... is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goats acute phase ... There was a significant response by Hp to C. pseudotuberculosis infection and PLD challenge. This was supported by the early ... Therefore, it concluded that C. pseudotuberculosis and PLD can influence the level of acute phase proteins in goats. ... Serum Hp concentration in goats challenged with C. pseudotuberculosis (inoculated with 1x109 cfu subcutaneously) showed a ...
Attenuation of Corynebacterium pseudotuberculosis by targeted mutagenesis of the phospholipase D gene.. Author:. McNamara, ... Attenuation of Corynebacterium pseudotuberculosis by targeted mutagenesis of the phospholipase D gene.. en_US. ... Attenuation of Corynebacterium pseudotuberculosis by targeted mutagenesis of the phospholipase D gene. ... A toxic phospholipase D (PLD), is thought to be an essential virulence determinant of Corynebacterium pseudotuberculosis, an ...
Corynebacterium pseudotuberculosis PAT10, complete genome. (EMBL: CP002924). Sequence length: 2335323. Download in FASTA format ... Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work.. Heggelund L, Gaustad P, ... Survival capacity of Corynebacterium pseudotuberculosis biovar ovis in different soil types from Chubut, Argentine Patagonia]. ... Whole-Genome Sequence of Corynebacterium pseudotuberculosis PAT10 Strain Isolated from Sheep in Patagonia, Argentina. Cerdeira ...
... genus Corynebacterium, C. diphtheriae, Corynebacterium diphtheriae.... What are synonyms for Corynebacterium pseudotuberculosis ... Antonyms for Corynebacterium pseudotuberculosis. 7 words related to corynebacterium: eubacteria, eubacterium, true bacteria, ... Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis.. Corynebacterium pseudotuberculosis, o agente ... Corynebacterium pseudotuberculosis infection in production animals/Infeccoes por corynebacterium pseudotuberculosis em animais ...
... pseudotuberculosis. Overall we provide valuable information of possible targets against C. pseudotuberculosis where some of ... The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, ... Corynebacterium pseudotuberculosis (Cp) is a pathogen of great veterinary and economic importance, since it affects a broad ... The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, ...
WHAT IS CORYNEBACTERIUM PSEUDOTUBERCULOSIS AND HOW DOES IT RELATE TO CASEOUS LYMPHADENITIS?. Corynebacterium pseudotuberculosis ... Infection with the organism occurs when Corynebacterium pseudotuberculosis penetrates through skin or mucous membranes. The ... Home , Products , Goat/Caprine , Corynebacterium Pseudotuberculosis/FAQ .entityContainerModule{ white-space:normal; /*border: ...
Corynebacterium pseudotuberculosis. (bacterium). Corynebacterium pseudotuberculosis is a Gram-positive, rod-shaped bacterium of ...
Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis. In: Veterinary Therapeutics. ... Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis. Veterinary Therapeutics. 2010; ... Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis. / Gorman, Jennifer K.; Gabriel ... title = "Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis", ...
  • In small ruminants C. pseudotuberculosis causes a disease called caseous lymphadenitis characterized by pyogranulomatous abscess formation. (wikipedia.org)
  • citation needed] Distribution of C. pseudotuberculosis is mostly traced by examining prevalence of caseous lymphadenitis, the bacterium's main pathological disease. (wikipedia.org)
  • citation needed] C. pseudotuberculosis also causes disease in horses, and should be considered prevalent in areas where cases of "pigeon fever" and "ulcerative lymphadenitis" have been recorded. (wikipedia.org)
  • Corynebacterium pseudotuberculosis is a bacterium which causes diseases such as caseous lymphadenitis in small ruminants, resulting in large-scale economic losses for agribusiness worldwide. (rsc.org)
  • Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a debilitating chronic disease of sheep and goats. (springer.com)
  • Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. (springer.com)
  • Corynebacterium pseudotuberculosis (Cp) is the causative agent of caseous lymphadenitis (CLA), a chronic bacterial disease of sheep and goats characterized by granulomatous inflammation of Iymph nodes. (uzh.ch)
  • Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis, a common disease in small ruminant populations throughout the world and responsible for a significant economic impact for producers. (biomedcentral.com)
  • To our knowledge, this is the first characterization of C. pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig ( Sus scrofa domesticus ). (biomedcentral.com)
  • This work represents the first report of Corynebacterium pseudotuberculosis from caseous lymphadenitis lesions in Black Alentejano pig and alerts for the importance of the establishment of suitable control and sanitary management practices to control the infection and avoid further dissemination of this important pathogen to other animal hosts. (biomedcentral.com)
  • The causative agent of Caseous Lymphadenitis (CLA) is Corynebacterium pseudotuberculosis . (thescipub.com)
  • Caseous lymphadenitis (CL) is a contagious infectious disease of small ruminants caused by Corynebacterium pseudotuberculosis . (biomedcentral.com)
  • We identified and characterized the hsp60-hsp10 bicistronic operon of the animal pathogen Corynebacterium pseudotuberculosis , a Gram-positive bacterium of the class Actinobacteria , which causes caseous lymphadenitis (CLA) in small ruminants. (biomedcentral.com)
  • Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis (CLA), or cheesy gland, which affects small ruminants (sheep and goats) and occasionally other hosts. (biomedcentral.com)
  • The pathologies associated with C. pseudotuberculosis are of great importance to veterinary medicine because this bacterium is considered the main etiologic agent of caseous lymphadenitis (CLA). (biomedcentral.com)
  • Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis . (biomedcentral.com)
  • The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, and oedema in a number of hosts, comprising ruminants, thereby intimidating economic and dairy industries worldwide. (biomedcentral.com)
  • Corynebacterium pseudotuberculosis is a bacterial organism that causes the disease commonly referred to as Caseous Lymphadenitis or CL. (texasvetlab.com)
  • Several enzyme-linked immunosorbent assays (ELISAs) have been developed for the detection of antibodies to Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis (CLA). (warwick.ac.uk)
  • Caseous lymphadenitis is a disease caused by C. pseudotuberculosis which brings significant economic losses to small ruminant producers worldwide. (dvs.gov.my)
  • Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. (conicyt.cl)
  • Caseous lymphadenitis, also called pseudotubercu losis, is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis that presents a worldwide distribution and has a high prevalence among small ruminants, also affecting cows, horses and other domestic animals ( Belchior et al 2006 ). (conicyt.cl)
  • Background Corynebacterium pseudotuberculosis is classified into two biovars, nitrate-negative biovar Ovis which is the etiologic agent of caseous lymphadenitis in small ruminants and nitrate-positive biovar Equi, which causes abscesses and ulcerative lymphangitis in equines. (ufla.br)
  • Corynebacterium Pseudotuberculosis Bacterin is for use in healthy goats, 3 months of age or older, as an aid in the prevention of pyogranulomas/caseous lymphadenitis (CL), a disease characterized by localized collections of pus. (valleyvet.com)
  • Previous works defining antigens that might be used as vaccine targets against Corynebacterium pseudotuberculosis , which is the causative agent of sheep and goat caseous lymphadenitis, have focused on secreted proteins produced in a chemically defined culture media. (biomedcentral.com)
  • Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in sheep and goats, which is an infectious disease responsible for a high level of economic losses in the livestock sector [ 1 ]. (biomedcentral.com)
  • Corynebacterium pseudotuberculosis , a Gram-positive intracellular pathogen, is the etiological agent of caseous lymphadenitis or CLA. (bvsalud.org)
  • Clinical strains are occasionally recovered from human cases of lymphadenitis, such as C. pseudotuberculosis FRC41 that was isolated from the inguinal lymph node of a 12-year-old girl with necrotizing lymphadenitis. (pasteur.fr)
  • Caseous lymphadenitis is an infectious disease caused by the bacterium Corynebacterium pseudotuberculosis, that affects the lymphatic system, resulting in abscesses in the lymph nodes and internal organs. (wikipedia.org)
  • Pyogranulomas/Caseous Lymphadenitis caused by Corynebacterium Pseudotuberculosis. (jefferspet.com)
  • We knocked out the phoP in C. pseudotuberculosis, the causal organism of caseous lymphadenitis (CLA), and using a combination of in vitro and in vivo mouse system, we showed for the first time, that the PhoP of C. pseudotuberculosis plays an important role in the virulence and pathogenicity of this bacterium. (jove.com)
  • Caseous Lymphadenitis (CL) is a chronic contagious disease affecting mainly sheep and goats This disease is also called pseudotuberculosis or often "abscesses," and has been referred to as the curse of the goat industry throughout the world. (goatworld.com)
  • Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that were isolated from different hosts, including representatives of the Ovis and Equi biovars. (nih.gov)
  • The chromosomal gene encoding the phospholipase D from Corynebacterium pseudotuberculosis (biovar ovis) isolate Whetten 1 was replaced with an allele containing a nonsense mutation. (nih.gov)
  • In this study, phenotypic and genotypic identification methods allocated the swine isolates in C. pseudotuberculosis biovar ovis. (biomedcentral.com)
  • The ERIC 1 + 2 Minimum-spanning tree from 367 strains of C. pseudotuberculosis showed that the great majority of biovar Ovis strains clustered together, but separately from biovar Equi strains that also clustered amongst themselves. (biomedcentral.com)
  • Using evolutionarily conserved genes ( rpoB, gapA, fusA, and rsmE ) and their corresponding amino acid sequences, we analyzed the phylogenetic relationship among eighteen strains of C. pseudotuberculosis belonging to both biovars Ovis and Equi. (biomedcentral.com)
  • Especially based on its ability to breakdown nitrate [ 19 , 20 ], C. pseudotuberculosis was classified into two biovars, Ovis and Equi. (biomedcentral.com)
  • In this study, PLD was purified from C. pseudotuberculosis biovar equi isolate 155 and the gene encoding PLD (pld) was cloned, pld from 155 and C. pseudotuberculosis biovar ovis isolate Whetten 1 were sequenced, Pld⁻ mutants of Whetten 1 were constructed, and one mutant was tested for reduced virulence for goats. (openrepository.com)
  • Survival capacity of Corynebacterium pseudotuberculosis biovar ovis in different soil types from Chubut, Argentine Patagonia]. (uni-bielefeld.de)
  • A simplified double immunodiffusion technique for detection of Corynebacterium ovis antigen. (warwick.ac.uk)
  • Conclusions The ability of the quadruplex assay to discriminate between C. pseudotuberculosis biovar Ovis and Equi strains enhances its usefulness in the clinical microbiology laboratory. (ufla.br)
  • Because these corynebacteria are also pathogenic in animals (eg, C ulcerans, C pseudotuberculosis, C ovis ), a history of exposure to sick animals or to animal products (eg, milk, offal, hides) is common. (medscape.com)
  • Barksdale L, Linder R, Sulea IT, Pollice M (1981) Phospholipase D activity of Corynebacterium pseudotuberculosis ( Corynebacterium ovis ) and Corynebacterium ulcerans , a distinctive marker within the genus Corynebacterium . (springer.com)
  • A disease known as ulcerative lymphagenitis can also result from infection with C. pseudotuberculosis in the distal limbs of horses. (wikipedia.org)
  • In horses Corynebacterium pseudotuberculosis causes infection of lower limbs, internal organs (lungs, liver, and kidneys), abscesses of the pectoral region, and contagious acne. (gopetsamerica.com)
  • 6,7 In the southwestern USA, Corynebacterium pseudotuberculosis infection is seasonal which peaks in the summer and fall. (gopetsamerica.com)
  • Mastitis is a well-known sign for a corynebacterium pseudotuberculosis infection. (vetcontact.com)
  • In conclusion, therefore, the present study concluded that the mycolic acid group revealed significant responses of testosterone hormone concentration, semen quality, and its related pro-inflammatory cytokines in bucks following infection but the severity lesser compared to Corynebacterium pseudotuberculosis group. (springer.com)
  • The present study investigated the involvement of MAPK pathways (MAPK p38, ERK 1 and ERK 2) with respect to the production of cytokines induced by antigens secreted by C. pseudotuberculosis over a 60-day course of infection. (biomedcentral.com)
  • The authors hypothesize that MAPK p38 and ERK 1 pathways with respect to TNF-α production, as well as the MAPK p38 and ERK 1 and 2 pathways in relation to IL-10 production under infection by C. pseudotuberculosis are important regulators of cellular response. (biomedcentral.com)
  • The adaptive resistance to infection caused by facultative intracellular bacteria, such as C. pseudotuberculosis, is related to CD4 T cells and, more specifically, to clones that produce Th1-type cytokines, mainly IFN-γ and TNF-α. (biomedcentral.com)
  • There was a significant response by Hp to C. pseudotuberculosis infection and PLD challenge. (biomedcentral.com)
  • Risk factors associated with Corynebacterium pseudotuberculosis infection in California horses. (freethesaurus.com)
  • Immunization of mice against Corynebacterium pseudotuberculosis infection. (freethesaurus.com)
  • Infection with the organism occurs when Corynebacterium pseudotuberculosis penetrates through skin or mucous membranes. (texasvetlab.com)
  • This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. (elsevier.com)
  • Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. (elsevier.com)
  • Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. (elsevier.com)
  • Considering that such antigens might not reflect the repertoire of proteins expressed during infection conditions, this experiment aimed to investigate the membrane-associated proteins with pathogenic potential expressed by C. pseudotuberculosis grown directly in animal serum. (biomedcentral.com)
  • Recently, efforts have been made to characterize the bacterial exoproteome and discover novel secreted antigens for use as vaccine candidates against C. pseudotuberculosis infection. (biomedcentral.com)
  • Bostock AD, Gilbert FR, Lewis D, Smith DC (1984) Corynebacterium ulcerans infection associated with untreated milk. (springer.com)
  • Does infection with Corynebacterium pseudotuberculosis interfere with TB testing in goats? (bmj.com)
  • It has been suggested that, due to antigenic similarities between this bacterium and mycobacteria, infection with C pseudotuberculosis can interfere with the diagnostic testing for tuberculosis (TB). (bmj.com)
  • CL is an infection of goats, caused by Corynebacterium pseudotuberculosis. (goatworld.com)
  • However, certain factors such as C. pseudotuberculosis infection and paratuberculosis vaccination can have a negative impact in the most sensitive tests. (csic.es)
  • This photomicrograph shows numerous Gram-positive non-spore-forming, rod-shaped, Corynebacterium diphtheriae bacteria. (cdc.gov)
  • Taxonomy of Corynebacterium diphtheriae and related taxa, with recognition of Corynebacterium ulcerans sp. (straininfo.net)
  • The group, often referred to as "coryneform," comprises taxonomically diverse gram-positive rods resembling Corynebacterium diphtheriae and displaying pleomorphism and irregular cellular arrangements ( 1 , 2 ). (cdc.gov)
  • Diphtheria is a paradigm of an infectious disease caused by the toxigenic bacteria Corynebacterium diphtheriae and Corynebacterium ulcerans . (springer.com)
  • Isolation of C. diphtheriae strains were reported from domestic cats and horses and animal reservoirs are even more common, when Corynebacterium ulcerans is taken into consideration, which has been detected as a commensal in various domestic and wild animals. (springer.com)
  • Allen CE, Schmitt MP (2009) HtaA is an iron-regulated hemin binding protein involved in the utilization of heme iron in Corynebacterium diphtheriae . (springer.com)
  • Barksdale L (1970) Corynebacterium diphtheriae and its relatives. (springer.com)
  • Bezjak V, Farsey SJ (1970a) Corynebacterium diphtheriae carriership in Ugandan children. (springer.com)
  • Bezjak V, Farsey SJ (1970b) Corynebacterium diphtheriae in skin lesions in Ugandan children. (springer.com)
  • Bibb LA, Schmitt MP (2010) The ABC transporter HrtAB confers resistance to hemin toxicity and is regulated in a hemin-dependent manner by the ChrAS two-component system in Corynebacterium diphtheriae . (springer.com)
  • Corynebacterium diphtheriae , the cause of diphtheria in humans. (wikidoc.org)
  • The diphtheria toxin repressor, DtxR, is a global iron-dependent regulatory protein in Corynebacterium diphtheriae that controls gene expression by binding to 19-bp operator sequences. (asm.org)
  • Corynebacterium diphtheriae is a gram-positive bacterium and the causative agent of diphtheria, a disease associated with severe infections of the upper respiratory tract and with skin ulcerations ( 19 ). (asm.org)
  • The primary structure of the corynebacterial PLDs were compared to those produced by Corynebacterium ulcerans and Arcanobacterium haemolyticum. (openrepository.com)
  • Corynebacterium ulcerans is a bacterial species with high importance because it causes infections in animals and, rarely, in humans. (jove.com)
  • Corynebacterium pseudotuberculosis strains belonging to biovar equi , however, cause edematous skin illness in buffalos. (frontiersin.org)
  • Genomic analysis of four strains of Corynebacterium pseudotuberculosis bv. (semanticscholar.org)
  • However, molecular evidence has not been established so far to understand this difference, specifically if these C. pseudotuberculosis strains are under an evolutionary process. (biomedcentral.com)
  • However, additional analyses using other genes and other bacterial strains are required to further support our anagenesis hypothesis in C. pseudotuberculosis . (biomedcentral.com)
  • Methods In the present study, genomes of C. pseudotuberculosis strains were used to identify the genes involved in the nitrate reduction pathway to improve a species identification three-primer multiplex PCR assay. (ufla.br)
  • The results of the quadruplex PCR of 348 strains, 346 previously well-characterized clinical isolates of C. pseudotuberculosis from different hosts (goats, sheep, horse, cattle, buffalo, llamas and humans), the vaccine strain 1002 and the type strain ATCC 19410T, were compared to the results of nitrate reductase identification by biochemical test. (ufla.br)
  • A toxic phospholipase D (PLD), is thought to be an essential virulence determinant of Corynebacterium pseudotuberculosis, an animal pathogen which causes chronic, suppurative infections. (openrepository.com)
  • In this work, we report the complete genome sequence of a Corynebacterium pseudotuberculosis PAT10 isolate, collected from a lung abscess in an Argentine sheep in Patagonia, whose pathogen also required an investigation of its pathogenesis. (uni-bielefeld.de)
  • Corynebacterium pseudotuberculosis is generally regarded as an important animal pathogen that rarely infects humans. (pasteur.fr)
  • Originally isolated by Magnusson in 1923 from granulomatous lung infections in young horses (3) , Corynebacterium (now Rhodococcus equi ) remains an important pathogen of foals. (cdc.gov)
  • citation needed] Shortly after, it was sampled from abscesses in a sheep by Hugo von Preisz [hu], and the bacteria was named the ''Preisz-Nocard'' bacillus until further work by German microbiologists in the mid 1900s, when it was re-categorized into the Corynebacterium genus. (wikipedia.org)
  • C. pseudotuberculosis is a gram-positive bacteria that can be either coccoid or filamentous rods, which can be organized into palisades. (wikipedia.org)
  • This bacteria is grown at 37 °C under aerobic or anaerobic conditions, thus C. pseudotuberculosis is a faculatative anaerobe. (wikipedia.org)
  • Our results confirm that phospholipase D is a virulence determinant of C. pseudotuberculosis that increases the persistence and spread of the bacteria within the host. (nih.gov)
  • These results confirm that PLD is a virulence determinant of C. pseudotuberculosis which allows the persistence and spread of the bacteria within the host. (openrepository.com)
  • Rhodococcus equi and Arcanobacterium haemolyticum, formerly classified in the genus Corynebacterium, are members of the loosely defined taxon "coryneform" bacteria. (cdc.gov)
  • A variety of factors contribute to the underreporting of human infections caused by bacteria in the genus Corynebacterium and closely related genera. (cdc.gov)
  • Pigeon fever also called Dryland Distemper is caused by the bacteria Corynebacterium pseudotuberculosis. (horsecity.com)
  • Pigeon fever is a disease caused by the bacteria Corynebacterium pseudotuberculosis. (quarterhorsenews.com)
  • To construct the DNA vaccine, the hsp60 gene of C. pseudotuberculosis was cloned in a mammalian expression vector. (biomedcentral.com)
  • The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. (conicyt.cl)
  • However, with advances in the genomic field, many C. pseudotuberculosis genes have already been characterized, mainly those related to virulence such as phospholipase D . Here, we examined the use of the several available genes of C. pseudotuberculosis and reviewed their applications in vaccine construction , more efficient diagnostics for CLA, and control of this disease , among other applications. (bvsalud.org)
  • A novel comparative genomics analysis for common drug and vaccine targets in Corynebacterium pseudotuberculosis and other CMN group of human pathogens. (crcpress.com)
  • citation needed] It was finally renamed Corynebacterium pseudotuberculosis in 1948, to reflect that the clinical disease signs were similar to disease cause by tuberculosis species. (wikipedia.org)
  • Studies have detected mis-assemblies in genomes of the species Corynebacterium pseudotuberculosis . (biomedcentral.com)
  • C. pseudotuberculosis is a relatively homogenous taxonomic group that can be distinguished from most Corynebacterium species by the production of Phospholipase D (PLD) and urease and the inability to ferment starch. (biomedcentral.com)
  • Other species belonging to the Corynebacterium genus have already been related to CLA. (biomedcentral.com)
  • The latter three genera, together with Corynebacterium , form a group of potentially pathogenic species termed the CMN group. (biomedcentral.com)
  • There are numerous reports on vaccination against C. pseudotuberculosis in ovine species, with few studies in goats ( Baird et al 2007 ). (conicyt.cl)
  • CDC is actively researching new laboratory methods to better identify and characterize other Bordetella and Corynebacterium species. (cdc.gov)
  • Results A novel quadruplex PCR assay for C. pseudotuberculosis species and biovar identification was developed. (ufla.br)
  • Given the paucity of susceptibility data, minimum inhibitory concentration interpretive criteria for the genus Corynebacterium can be extrapolated to Arcanobacterium (Trueperella) species for interpretation [22]. (thefreedictionary.com)
  • Qualitative analysis in the studied workplaces revealed presence of 19 bacterial species belonging to 14 genera (Table 3), including 3 species of the genus Corynebacterium , and another 3 species of the genus Staphylococcus, and 2 of the genus Bacillus. (thefreedictionary.com)
  • Belmares J, Detterline S, Pak JB, Parada JP (2007) Corynebacterium endocarditis species-specific risk factors and outcomes. (springer.com)
  • Some nondiphtheria species of Corynebacterium produce disease in specific animal species, and some of these are also human pathogens . (wikidoc.org)
  • Some species of Corynebacterium have sequenced genomes that range in size from 2.5 - 3 Mbp. (wikidoc.org)
  • Species of Corynebacterium have been used in the mass production of various amino acids including L-Glutamic Acid , a popular food additive that is made at a rate of 1.5 million tons/ year by Corynebacterium. (wikidoc.org)
  • The study was carried out in 26 goats infected by intradermal inoculation of 5, 20 and 100 C. pseudotuberculosis cells. (eurekamag.com)
  • There is paucity of information on the proinflammatory cytokine (IL-1β and IL-6) responses due to C. pseudotuberculosis and Mycolic Acid (MAs) inoculation in goats. (thescipub.com)
  • This study was conducted to investigate the response of acute phase proteins, mainly haptoglobin (Hp), serum amyloid A (SAA) and the negative acute phase response, especially albumin after an experimental challenge of C. pseudotuberculosis and phospholipase D (PLD) in Cross bred Boer goats. (biomedcentral.com)
  • Serum Hp concentration in goats challenged with C. pseudotuberculosis (inoculated with 1x10 9 cfu subcutaneously) showed a significant increase, 5 fold in males (0.98 ± 0.12 mg/ml) and 3 fold in females (0.66 ± 0.12 mg/ml) compared to the control (0.2 ± 0.02 mg/ml). (biomedcentral.com)
  • Therefore, it concluded that C. pseudotuberculosis and PLD can influence the level of acute phase proteins in goats. (biomedcentral.com)
  • Identification of Corynebacterium pseudotuberculosis isolates from sheep and goats by PCR. (warwick.ac.uk)
  • Moxoto goats (n=17) were experimentally inoculated intradermally with broth culture containing varying numbers of living Corynebacterium pseudotuberculosis and its exotoxin, five goats with broth culture supernatant containing solely crude exotoxin and five goats with washed C. pseudotuberculosis suspended in physiological saline. (elsevier.com)
  • Compared with controls, Moxoto goats inoculated with broth cultures of C. pseudotuberculosis and exotoxin, or solely with the crude exotoxin, became acutely ill, with depression, rises in rectal temperature and edema at the site of inoculation. (elsevier.com)
  • Kass, P. H. / Observations on goats experimentally infected with Corynebacterium pseudotuberculosis . (elsevier.com)
  • CAUSE: Also referred to as "boils" this disease is caused by bacterium CORYNEBACTERIUM PSEUDOTUBERCULOSIS. (tvsp.org)
  • In the present work, we evaluate and propose a methodology for the use of the Ion Torrent PGM platform for decoding the gram-positive bacterium Corynebacterium pseudotuberculosis, for which 15 complete genome sequences have already been deposited based on fragment and mate-paired libraries with a 3-kb insert size. (uni-bielefeld.de)
  • Complete Genome Sequence of Corynebacterium pseudotuberculosis strain - CIP 52.97- isolated from Horse in Kenya. (crcpress.com)
  • Vilela, C. L. / Characterization of virulence factors of Corynebacterium pseudotuberculosis field isolates . (dtu.dk)
  • Furthermore, swine isolates were compared with C. pseudotuberculosis from caprines and PFGE patterns also showed high similarity, suggesting the prevalence of dominant clones and a potential cross-dissemination between these two animal hosts. (biomedcentral.com)
  • The control of diphtheria in industrialized countries and the subsequent deemphasis of the genus Corynebacterium have contributed to discounting isolates characteristic of the genus as contaminants. (cdc.gov)
  • The biotype of Corynebacterium pseudotuberculosis affecting horses and cattle is distinguishable from the biotype that infects small ruminants based on its ability to reduce nitrate in vitro. (wikipedia.org)
  • Corynebacterium pseudotuberculosis is a gram-positive bacterium known globally to infect ruminants, horses and, rarely, people. (wikipedia.org)
  • Corynebacterium pseudotuberculosis is a facultative, intracellular, Gram-positive bacterium of the class Actinobacteria , which also includes the genera Mycobacterium, Nocardia and Rhodococcus . (biomedcentral.com)
  • 3 Once established in the host, Corynebacterium pseudotuberculosis evades the immune system with relative ease, causing chronic infections that persist for the life of the animal. (gopetsamerica.com)
  • Use of a real-time polymerase chain reaction-based fluorogenic 5' nuclease assay to evaluate insect vectors of Corynebacterium pseudotuberculosis infections in horses. (semanticscholar.org)
  • Multiplex polymerase chain reaction to identify and determine the toxigenicity of Corynebacterium spp with zoonotic potential and an overview of human and animal infections. (semanticscholar.org)
  • The genus Corynebacterium belongs to the bacterial phylum Actinobacteria , also known as Actinomycetes . (biomedcentral.com)
  • Furthermore, we modeled the PhoP of C. pseudotuberculosis and our docking results showed that several natural compounds including Rhein, an anthraquinone from Rheum undulatum, and some drug-like molecules may target PhoP to inhibit the TCS of C. pseudotuberculosis, and therefore may facilitate a remarkable attenuation of bacterial pathogenicity being the CLA. (jove.com)
  • As vector patterns change with warming temperatures, "Corynebacterium pseudotuberculosis" in horses is re-emerging in the United States. (wikipedia.org)
  • Corynebacterium pseudotuberculosis biovar equi is the causative agent of "pigeon fever," or "dryland distemper" in horses. (hindawi.com)
  • This report describes the clinical findings of two horses in Iowa that presented with pectoral abscessation, confirmed in one to be C. pseudotuberculosis biovar equi . (hindawi.com)
  • OBJECTIVE To develop and use a sensitive molecular assay for detecting the phospholipase D (PLD) exotoxin gene of Corynebacterium pseudotuberculosis in an attempt to identify insect vectors that may be important in transmission of clinical disease in horses. (semanticscholar.org)
  • The relationship between Corynebacterium pseudotuberculosis biovar equi phenotype with location and extent of lesions in horses. (semanticscholar.org)
  • Corynebacterium pseudotuberculosis was isolated from the facial wounds in both horses. (elsevier.com)
  • Corynebacterium pseudotuberculosis is a Gram-positive pathogenic bacterium belonging to the class Actinobacteria, which is a member of the Corynebacterium , Mycobacterium , Nocardia and Rhodococcus genera (the CMNR group). (beds.ac.uk)
  • Comparison of cell wall antigens of Corynebacterium pseudotuberculosis and Mycobacterium tuberculosis. (ttu.edu)
  • uma plataforma de an lise interativa para estudar redes regulat rias transcricionais dos g neros Corynebacterium e Mycobacterium, Ano de obten o: 2014. (cnpq.br)
  • In this work, we present the resequencing of Corynebacterium pseudotuberculosis strain 1002 (Cp1002). (biomedcentral.com)
  • The completion of whole-genome sequencing for Corynebacterium pseudotuberculosis strain 1002 has contributed to major advances in research aimed at understanding the biology of this microorganism. (beds.ac.uk)
  • To our knowledge, this approach allowed characterization of the exoproteome of a C. pseudotuberculosis equi strain for the first time. (frontiersin.org)
  • Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. (frontiersin.org)
  • In the present study, we describe the complete genome of the Corynebacterium pseudotuberculosis Cp316 strain, biovar equi, isolated from the abscess of a North American horse. (monash.edu)
  • Corynebacterium pseudotuberculosis is a minuscule, Gram-positive, pleomorphic, non-sporulating facultative anaerobic bacillus. (biomedcentral.com)
  • Corynebacterium is a genus of Gram-positive , facultatively anaerobic , non- motile , rod-shaped actinobacteria . (wikidoc.org)
  • To detect potential virulence factors and corresponding gene-regulatory networks in this human isolate, the genome sequence of C. pseudotuberculosis FCR41 was determined by pyrosequencing and functionally annotated. (pasteur.fr)
  • But this very interesting article from Israel describes a corynebacterium pseudotuberculosis outbreak in a dairy cattle herd causing both ulcerative granulomatous skin lesions and mastitis. (vetcontact.com)
  • C. pseudotuberculosis organisms that were isolated from the ulcerative granulomatous lesions and from milk samples failed to reduce nitrate. (vetcontact.com)
  • These results will serve as a basis for further studies on the pathogenicity of C. pseudotuberculosis bv. (jove.com)
  • Attenuation of Corynebacterium pseudotuberculosis by targeted mutagenesis of the phospholipase D gene. (openrepository.com)
  • In vitro IFN-gamma production by goat blood cells after stimulation with somatic and secreted Corynebacterium pseudotuberculosis antigens. (freethesaurus.com)
  • Corynebacterium pseudotuberculosis is a Gram-positive, rod-shaped bacterium of the Corynebacteriaceae family. (hartmann-academie.nl)
  • Bacteriological characterization of Corynebacterium pseudotuberculosis in Venezuelan goat flocks. (freethesaurus.com)
  • Isolation of Corynebacterium falsenii and description of Corynebacterium aquilae sp. (straininfo.net)
  • The present work describes the identification and isolation of Corynebacterium pseudotuberculosis and Actinomyces bovis in a naturally infected herd in the region of Ribatejo. (grupolusofona.pt)
  • CC Corynebacterium pseudotuberculosis FRC41 chromosome, complete genome. (univ-lyon1.fr)
  • Moreover, this study enhances our understanding of the factors that may influence the pathogenesis of C. pseudotuberculosis . (frontiersin.org)
  • Out of 31 globally druggable targets, 9 targets have already been reported in other pathogenic microorganisms, 3 of them (3-isopropylmalate dehydratase small subunit, 50S ribosomal protein L30, Chromosomal replication initiator protein DnaA) in C. pseudotuberculosis . (biomedcentral.com)
  • Thus, this study aimed to investigate the membrane-associated proteins with pathogenic potential expressed by C. pseudotuberculosis grown directly in animal serum. (biomedcentral.com)
  • Six animals acted as controls and seven were experimentally infected with C pseudotuberculosis . (bmj.com)
  • Corynebacterium pseudotuberculosis can be classified into two biovars or biovars based on their nitrate-reducing ability. (biomedcentral.com)
  • Pseudotuberculosis is characterised by the formation of encapsulated abscesses containing thick, caseous pus, most frequently within peripheral lymph nodes, but also within internal lymph nodes and organs ( Fontaine et al 2006 ). (conicyt.cl)
  • Alterations in the phospholipid composition and morphology of ovine erythrocytes after intravenous inoculation of Corynebacterium pseudotuberculosis . (springer.com)
  • Within the genus Corynebacterium , the CuNIR proteins are found to have similar sizes to that of C. (thefreedictionary.com)
  • The resulting improved epidemiology and taxonomy have led, for example, to the definition of CDC groups JK and D-2 in the genus Corynebacterium , now recognized as important opportunistic pathogens (1) . (cdc.gov)
  • In this work, we report the whole-genome sequence of Corynebacterium pseudotuberculosis bv. (jove.com)
  • Little is known about the buck's reproductive pathophysiology with respect to inoculation with Corynebacterium pseudotuberculois and its immunogen mycolic acid extract. (springer.com)
  • In silico identification of essential proteins in Corynebacterium pseudotuberculosis based on protein-protein interaction networks. (uni-bielefeld.de)
  • The McNemar's Chi-squared test used to compare the two methods used for C. pseudotuberculosis biovar identification showed no significant difference (P = 0.75) [95% CI for odds ratio (0.16-6.14)] between the quadruplex PCR and the nitrate biochemical test. (ufla.br)
  • These findings show that secretion and secreted proteins are key elements in the virulence and adaptation of C. pseudotuberculosis . (frontiersin.org)