Corynebacterium diphtheriae: A species of gram-positive, asporogenous bacteria in which three cultural types are recognized. These types (gravis, intermedius, and mitis) were originally given in accordance with the clinical severity of the cases from which the different strains were most frequently isolated. This species is the causative agent of DIPHTHERIA.Corynebacterium: A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.Diphtheria: A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.Corynebacterium Infections: Infections with bacteria of the genus CORYNEBACTERIUM.Diphtheria Toxin: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.Corynebacterium glutamicum: A species of gram-positive, asporogenous, non-pathogenic, soil bacteria that produces GLUTAMIC ACID.Diphtheria Antitoxin: An antitoxin produced against the toxin of CORYNEBACTERIUM DIPHTHERIAE that is used for the treatment of DIPHTHERIA.Corynebacterium pseudotuberculosis: A species of gram-positive, asporogenous bacteria that was originally isolated from necrotic areas in the kidney of a sheep. It may cause ulcerative lymphangitis, abscesses, and other chronic purulent infections in sheep, horses, and other warm-blooded animals. Human disease may form from contact with infected animals.Ribotyping: RESTRICTION FRAGMENT LENGTH POLYMORPHISM analysis of rRNA genes that is used for differentiating between species or strains.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Heme Oxygenase (Decyclizing): A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.Bacterial Proteins: Proteins found in any species of bacterium.Siderophores: Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)Lysogeny: The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.Bacteriophages: Viruses whose hosts are bacterial cells.Pharynx: A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).RussiaGene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Diphtheria Toxoid: The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.Genes, Bacterial: The functional hereditary units of BACTERIA.Propionibacterium acnes: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.Skin Diseases, Infectious: Skin diseases caused by bacteria, fungi, parasites, or viruses.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Random Amplified Polymorphic DNA Technique: Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.Hemin: Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Peptide Elongation Factor 1: Peptide elongation factor 1 is a multisubunit protein that is responsible for the GTP-dependent binding of aminoacyl-tRNAs to eukaryotic ribosomes. The alpha subunit (EF-1alpha) binds aminoacyl-tRNA and transfers it to the ribosome in a process linked to GTP hydrolysis. The beta and delta subunits (EF-1beta, EF-1delta) are involved in exchanging GDP for GTP. The gamma subunit (EF-1gamma) is a structural component.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Thiamine: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.ThiazolesMyasthenia Gravis: A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)Streptococcus intermedius: A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharynx flora and has a proclivity for abscess formation, most characteristically in the CENTRAL NERVOUS SYSTEM and LIVER.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Pharyngitis: Inflammation of the throat (PHARYNX).Nasopharynx: The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.Fimbriae Proteins: Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).Fimbriae, Bacterial: Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).Hexylresorcinol: A substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.Travel: Aspects of health and disease related to travel.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Pteridines: Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.Coenzymes: Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes.Metalloproteins: Proteins that have one or more tightly bound metal ions forming part of their structure. (Dorland, 28th ed)Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)Sulfurtransferases: Enzymes which transfer sulfur atoms to various acceptor molecules. EC 2.8.1.South Africa: A republic in southern Africa, the southernmost part of Africa. It has three capitals: Pretoria (administrative), Cape Town (legislative), and Bloemfontein (judicial). Officially the Republic of South Africa since 1960, it was called the Union of South Africa 1910-1960.Diphtheria-Tetanus Vaccine: A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.Health Promotion: Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.

Control of corynebacteriophage reproduction by heteroimmune repression. (1/354)

Corynebacteriophages beta and gamma are closely related but heteroimmune; hence, gamma reproduces in C7(beta). A series of gamma mutants, designated gamma-bin (beta-inhibited), has been isolated. They reproduce in only 2 to 14% of infected C7(beta) cells, and, as a result, plaque with an efficiency of 10(-4) to 10(-5) on this strain. The proportion of C7(beta) cells in which gamma-bin phage can replicate is increased to 30 to 80% when immunity is lifted by UV induction of C7(beta) or by heat induction of C7(beta-tsr3). The gamma-bin mutants carry out a normal vegetative or lysogenic cycle in strain C7 and thus do not appear to be defective in any essential phage function. Infection of C7(beta) by gamma-bin results in cell killing whether the infection is productive or nonproductive. The data support the hypothesis that inhibition of gamma-bin is due to the direct or indirect action of a beta prophage gene. The simplest hypothesis is that gamma-bin phages have sustained mutations in an operator site and that beta repressor now combines with the mutated operator to inhibit normal replication in a significant proportion of infected cells.  (+info)

Use of molecular subtyping to document long-term persistence of Corynebacterium diphtheriae in South Dakota. (2/354)

Enhanced surveillance of patients with upper respiratory symptoms in a Northern Plains community revealed that approximately 4% of them were infected by toxigenic Corynebacterium diphtheriae of both mitis and gravis biotypes, showing that the organism is still circulating in the United States. Toxigenic C. diphtheriae was isolated from five members of four households. Four molecular subtyping methods-ribotyping, multilocus enzyme electrophoresis (MEE), random amplified polymorphic DNA (RAPD), and single-strand conformation polymorphism-were used to molecularly characterize these strains and compare them to 17 archival South Dakota strains dating back to 1973 through 1983 and to 5 isolates collected from residents of diverse regions of the United States. Ribotyping and RAPD clearly demonstrated the household transmission of isolates and provided precise information on the circulation of several distinct strains within three households. By MEE, most recent and archival South Dakota strains were identified as closely related and clustered within the newly identified ET (electrophoretic type) 215 complex. Furthermore, three recent South Dakota isolates and eight archival South Dakota isolates were indistinguishable by both ribotyping and RAPD. All of these molecular methods showed that recent South Dakota isolates and archival South Dakota isolates were more closely related to each other than to the C. diphtheriae strains isolated in other parts of the United States or worldwide. The data also supported the improbability of importation of C. diphtheriae into this area and rather strongly suggest the long-term persistence of the organism in this region.  (+info)

Quantitative studies on competitive activities of skin bacteria growing on solid media. (3/354)

Earlier quantitative investigations of antagonism between skin bacteria were based on the use of liquid cultures, but a more realistic model has now been devised, based on the use of the surfaces of solid media. Pure or mixed inocula were spread evenly over suitable agar media in Petri dishes marked out with a standard grid. Growth curves were constructed from viable counts of the surface bacteria after they had been removed from excised squares of the agar media and dispersed. The method was highly reproducible, and competitive interactions were revealed more clearly than in studies with liquid media. An antibiotic-producing strain of Staphylococcus epidermidis (S6+) readily suppressed strains of Micrococcus, Corynebacterium and Streptococcus species. However, a Staphylococcus aureus strain which was less sensitive to the antibiotic effect of S6+ interacted in a complex manner, depending on the absolute and relative size of the S6+ inoculum.  (+info)

Resurgent diphtheria--are we safe? (4/354)

Diphtheria, one of the major causes of morbidity and mortality in the past, seemed nearly eliminated from industrialized countries, thanks to improved hygienic conditions and large scale vaccinations. In 1990, a large epidemic started in Eastern Europe, mainly in Russia and Ukraine, with over 70,000 cases reported within a 5 year period. The main factors leading to the epidemic included low immunization coverage among infants and children, waning immunity to diphtheria among adults, and profound social changes in the former Soviet Union. The possibility of new virulence factors in the epidemic strain has not yet been ruled out. Even though immunity among adults is far from complete in Western Europe, the epidemic did not spread there. The main reason for this might be the good immune status of children and lack of social turbulence favouring the spread of infection. Several countries have also taken preventive measures, which may also have played a role in protection against the potential epidemic.  (+info)

Emergence of related nontoxigenic Corynebacterium diphtheriae biotype mitis strains in Western Europe. (5/354)

We report on 17 isolates of Corynebacterium diphtheriae biotype mitis with related ribotypes from Switzerland, Germany, and France. Isolates came from skin and subcutaneous infections of injecting drug users, homeless persons, prisoners, and elderly orthopedic patients with joint prostheses or primary joint infections. Such isolates had only been observed in Switzerland.  (+info)

Heme degradation as catalyzed by a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae. (6/354)

Hmu O, a heme degradation enzyme in the pathogen Corynebacterium diphtheriae, catalyzes the oxygen-dependent conversion of hemin to biliverdin, carbon monoxide, and free iron. A bacterial expression system using a synthetic gene coding for the 215-amino acid, full-length Hmu O has been constructed. Expressed at very high levels in Escherichia coli BL21, the enzyme binds hemin stoichiometrically to form a hexacoordinate high spin hemin-Hmu O complex. When ascorbic acid is used as the electron donor, Hmu O converts hemin to biliverdin with alpha-hydroxyhemin and verdoheme as intermediates. The overall conversion rate to biliverdin is approximately 4-fold slower than that by rat heme oxygenase (HO) isoform 1. Reaction of the hemin-Hmu O complex with hydrogen peroxide yields a verdoheme species, the recovery of which is much less compared with rat HO-1. Reaction of the hemin complex with meta-chloroperbenzoic acid generates a ferryl oxo species. Thus, the catalytic intermediate species and the nature of the active form in the first oxygenation step of Hmu O appear to be similar to those of the mammalian HO. However, the considerably slow catalytic rate and low level of verdoheme recovery in the hydrogen peroxide reaction suggest that the active-site structure of Hmu O is different from that of its mammalian counterpart.  (+info)

The heme complex of Hmu O, a bacterial heme degradation enzyme from Corynebacterium diphtheriae. Structure of the catalytic site. (7/354)

Hmu O, a heme degradation enzyme in Corynebacterium diphtheriae, forms a stoichiometric complex with iron protoporphyrin IX and catalyzes the oxygen-dependent conversion of hemin to biliverdin, carbon monoxide, and free iron. Using a multitude of spectroscopic techniques, we have determined the axial ligand coordination of the heme-Hmu O complex. The ferric complex shows a pH-dependent reversible transition between a water-bound hexacoordinate high spin neutral pH form and an alkaline form, having high spin and low spin states, with a pK(a) of 9. (1)H NMR, EPR, and resonance Raman of the heme-Hmu O complex establish that a neutral imidazole of a histidine residue is the proximal ligand of the complex, similar to mammalian heme oxygenase. EPR of the deoxy cobalt porphyrin IX-Hmu O complex confirms this proximal histidine coordination. Oxy cobalt-Hmu O EPR reveals a hydrogen-bonding interaction between the O(2) and an exchangeable proton in the Hmu O distal pocket and two distinct orientations for the bound O(2). Mammalian heme oxygenase has only one O(2) orientation. This difference and the mixed spin states at alkaline pH indicate structural differences in the distal environment between Hmu O and its mammalian counterpart.  (+info)

Identification of a two-component signal transduction system from Corynebacterium diphtheriae that activates gene expression in response to the presence of heme and hemoglobin. (8/354)

Corynebacterium diphtheriae, the causative agent of diphtheria, utilizes various host compounds to acquire iron. The C. diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme and hemoglobin as iron sources. Transcription of the hmuO gene in C. diphtheriae is controlled under a dual regulatory mechanism in which the diphtheria toxin repressor protein (DtxR) and iron repress expression while either heme or hemoglobin is needed to activate transcription. In this study, two clones isolated from a C. diphtheriae chromosomal library were shown to activate transcription from the hmuO promoter in Escherichia coli. Sequence analysis revealed that these activator clones each carried distinct genes whose products had significant homology to response regulators of two-component signal transduction systems. Located upstream from each of these response regulator homologs are partial open reading frames that are predicted to encode the C-terminal portions of sensor kinases. The full-length sensor kinase gene for each of these systems was cloned from the C. diphtheriae chromosome, and constructs each carrying one complete sensor kinase gene and its cognate response regulator were constructed. One of these constructs, pTSB20, which carried the response regulator (chrA) and its cognate sensor kinase (chrS), was shown to strongly activate transcription from the hmuO promoter in a heme-dependent manner in E. coli. A mutation in chrA (chrAD50N), which changed a conserved aspartic acid residue at position 50, the presumed site of phosphorylation by ChrS, to an asparagine, abolished heme-dependent activation. These findings suggest that the sensor kinase ChrS is involved in the detection of heme and the transduction of this signal, via a phosphotransfer mechanism, to the response regulator ChrA, which then activates transcription of the hmuO promoter. This is the first report of a bacterial two-component signal transduction system that controls gene expression through a heme-responsive mechanism.  (+info)

*Corynebacterium diphtheriae

... is the scientific name for the disease diphtheria. Corynebacterium diptheriae is a rod-shaped, Gram ... Transcription Factors and Regulatory Networks Corynebacterium diphtheriae genome Type strain of Corynebacterium diphtheriae at ... Corynebacterium diphtheriae is the pathogenic bacterium that causes diphtheria. It is also known as the Klebs-Löffler bacillus ... Sangal, V; Tucker, N. P.; Burkovski, A; Hoskisson, P. A. (2012). "The draft genome sequence of Corynebacterium diphtheriae bv. ...

*Diphtheria toxin

Murphy JR (1996). "Corynebacterium Diphtheriae: Diphtheria Toxin Production". In Baron S; et al. Medical microbiology (4th ed ... Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. ... "Studies on the virulence of bacteriophage-infected strains of Corynebacterium diphtheriae". J. Bacteriol. 61 (6): 675-88. PMC ... "Further observations on the change to virulence of bacteriophage-infected avirulent strains of Corynebacterium diphtheria". J. ...

*ADP-ribosylation

... and Diphtheria toxin of Corynebacterium diphtheriae. Histone code Cell signaling PARP-1 Cholera toxin NAD+ ADP- ... The first appearance of mono-ADP-ribosylation occurred a year later during a study of toxins: corynebacterium diphtheria ...

*Tonsillitis

Rarely bacteria such as Neisseria gonorrhoeae, Corynebacterium diphtheriae, or Haemophilus influenzae may be the cause. ... Corynebacterium diphtheriae, Treponema pallidum, and Neisseria gonorrhoeae. Anaerobic bacteria have been implicated in ...

*Protein primary structure

This modification is a target for the powerful toxins of disparate bacteria, e.g., Vibrio cholerae, Corynebacterium diphtheriae ...

*Löffler's medium

Buck, in 1949, described a modified Loeffler's medium for cultivating Corynebacterium diphtheriae. This medium has a variety of ... A modified Loeffler's medium for cultivating Corynebacterium diphtheriae. J. Lab. Clin. Med. 34:582-583.. ... Routine laboratory examinations for C. diphtheriae. J. Lab. Clin. Med. 25:71-78. Buck, T.C. 1949. ... primary value of Loeffler medium is in the growth and morphological characterization of members of the genus Corynebacterium. ...

*Corynebacteriophage

It introduces toxigenicity into strains of Corynebacterium diphtheriae. Julie K. Segman, ed. (2006). Stedman's Medical ...

*Sortase

Kang HJ, Paterson NG, Gaspar AH, Ton-That H, Baker EN (October 2009). "The Corynebacterium diphtheriae shaft pilin SpaA is ... Mandlik A, Swierczynski A, Das A, Ton-That H (April 2007). "Corynebacterium diphtheriae employs specific minor pilins to target ... Gaspar AH, Ton-That H (February 2006). "Assembly of distinct pilus structures on the surface of Corynebacterium diphtheriae". ... Ton-That H, Schneewind O (November 2003). "Assembly of pili on the surface of Corynebacterium diphtheriae". Molecular ...

*Elek's test

... is an in vitro virulence test performed upon Corynebacterium diphtheriae. It is used to test for toxigenicity of C. diphtheriae ... "Tissue culture method for toxigenicity testing of Corynebacterium diphtheriae". Appl Microbiol. 16 (11): 1748-52. PMC 547753 . ...

*Bacteriophage

Examples are the conversion of harmless strains of Corynebacterium diphtheriae or Vibrio cholerae by bacteriophages to highly ... ISBN 978-0-07-893649-4. Mokrousov I (January 2009). "Corynebacterium diphtheriae: genome diversity, population structure and ...

*Lysogenic cycle

Examples: Corynebacterium diphtheriae produces the toxin of diphtheria only when it is infected by the phage β. In this case, ... Mokrousov I (January 2009). "Corynebacterium diphtheriae: genome diversity, population structure and genotyping perspectives". ...

*Diphtheria

Current nomenclature is Corynebacterium diphtheriae. Friedrich Loeffler was the first person to cultivate C. diphtheriae in ... Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Signs and symptoms may vary from mild to severe ... Freeman, Victor J (1951). "Studies on the Virulence of Bacteriophage-Infected Strains of Corynebacterium Diphtheriae". Journal ... Over the period of time, it was called Microsporon diphtheriticum, Bacillus diphtheriae, and Mycobacterium diphtheriae. ...

*Diphtheria antitoxin

It works by neutralizing the toxins produced by Corynebacterium diphtheriae. Diphtheria antitoxin was developed and came into ...

*Exotoxin

Well-known exotoxins include: botulinum toxin produced by Clostridium botulinum; Corynebacterium diphtheriae toxin, produced ... Clostridium tetani and Corynebacterium diphtheriae respectively. Vaccination with the toxoids generates antibodies against the ...

*Cutaneous diphtheria infection

Cutaneous diphtheria is an infection of the skin by Corynebacterium diphtheriae. It is also known as "desert sore". Diphtheria ...

*Conjunctivitis

... diphtheriae. Corynebacterium diphtheriae causes membrane formation in conjunctiva of non-immunized children.[citation needed] ...

*List of sequenced bacterial genomes

2003). "The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129". Nucleic Acids Res. 31 (22): 6516- ... 2005). "Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid- ... complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium ...

*Horizontal gene transfer

Freeman, Victor J (1951). "Studies on the virulence of bacteriophage-infected strains of Corynebacterium Diphtheriae". Journal ... in a paper demonstrating that the transfer of a viral gene into Corynebacterium diphtheriae created a virulent strain from a ...

*Diphtheria vaccine

... is a vaccine against Corynebacterium diphtheriae, the bacterium that causes diphtheria. Its use has resulted ...

*Cord factor

Kato, M (March 1970). "Action of a toxic glycolipid of Corynebacterium diphtheriae on mitochondrial structure and function". ...

*Corynebacterium amycolatum

One of its best known relatives is Corynebacterium diphtheriae, the causative agent of diphtheria. C. amycolatum is a common ... Corynebacterium endocarditis usually infects the left side of the heart in males, though C. amycolatum has shown a predilection ... Corynebacterium amycolatum is a Gram-positive, nonspore-forming, aerobic or facultatively anaerobic bacillus capable of ... Type strain of Corynebacterium amycolatum at BacDive - the Bacterial Diversity Metadatabase Biology portal. ...

*Edwin Klebs

In 1883, Klebs successfully identified the bacterium Corynebacterium diphtheriae as the etiological cause of diphtheria. This ... now Corynebacterium diphtheriae). He was the father of physician Arnold Klebs. Klebs was born in Königsberg, Province of ...

*EEF2

It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa). The ...

*CRM197

The gene for CRM197 has been cloned into Corynebacterium diphtheriae, the bacteria that produces the native toxin. Like the ...

*Upper respiratory tract infection

Corynebacterium diphtheriae, Bordetella pertussis, and Bacillus anthracis[citation needed]. Sexually transmitted infections ...

*Pneumococcal conjugate vaccine

Corynebacterium diphtheriae). The vaccine's polysaccharide sugars are grown separately in soy peptone broths. Through reductive ... CRM197 is grown in C. diphtheriae strain C7 in a medium of casamino acids and yeast extracts. The original seven-valent ...
BACKGROUND: The reemergence of epidemic diphtheria in Belarus in 1990s has provided us with important information on the biology of the disease and the diversity of the causative agent Corynebacterium diphtheriae. Molecular investigations were conducted with the aim to analyze the genetic variability of C diphtheriae during the post-epidemic period. METHODS: The biotype and toxigenicity status of 3513 C. diphtheriae strains isolated from all areas in Belarus during a declining period of diphtheria morbidity (1996-2005) was undertaken. Of these, 384 strains were isolated from diphtheria cases, 1968 from tonsillitis patients, 426 from contacts and 735 from healthy carriers. Four hundred and thirty two selected strains were ribotyped. RESULTS: The C diphtheriae gravis biotype, which was prevalent during 1996-2000, was replaced by the mitis biotype during 2001-2005. The distribution of toxigenic C. diphtheriae strains also decreased from 47.1% (1996) to 5.8% (2005). Changes in the distribution of the
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Four subspecies are recognized: C. d. mitis, C. d. intermedius, C. d. gravis, and C. d. belfanti. The four subspecies differ slightly in their colonial morphology and biochemical properties, such as the ability to metabolize certain nutrients, but all may be toxigenic (and therefore cause diphtheria) or not toxigenic. C. diphtheriae produces diphtheria toxin which alters protein function in the host by inactivating the elongation factor EF-2. This causes pharyngitis and pseudomembrane in the throat. The diphtheria toxin gene is encoded by a bacteriophage found in toxigenic strains, integrated into the bacterial chromosome. To accurately identify C. diphtheriae, a Gram stain is performed to show Gram-positive, highly pleomorphic organisms with no particular arrangement. Special stains like Alberts stain and Ponders stain are used to demonstrate the metachromatic granules formed in the polar regions. The granules are called polar granules, Babes Ernst granules, volutin, etc. An enrichment ...
We report an annotated draft genome of the human pathogen Corynebacterium diphtheriae bv. intermedius NCTC 5011. This strain is the first C. diphtheriae bv. intermedius strain to be sequenced, and our results provide a useful comparison to the other primary disease-causing biovars, C. diphtheriae bv. gravis and C. diphtheriae bv. mitis. The sequence has been deposited at DDBJ/EMBL/GenBank with the accession number AJVH01000000.. ...
Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic transmission was identified. Molecular methods distinguished the feline isolates from known C. diphtheriae.. ...
Sangal, Vartul, Blom, Jochen, Sutcliffe, Iain, von Hunolstein, Christina, Burkovski, Andreas and Hoskisson, Paul (2015) Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome. BMC Genomics, 16 (1). p. 765. ISSN 1471-2164 Sangal, Vartul, Burkovski, Andreas, Hunt, Alison, Edwards, Becky, Blom, Jochen and Hoskisson, Paul (2014) A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing. Infection, Genetics and Evolution, 21. pp. 54-57. ISSN 1567-1348 Sangal, Vartul, Fineran, Peter and Hoskisson, Paul (2013) Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae. Microbiology, 159 (Pt 10). pp. 2118-26. ISSN 1465-2080 Sangal, Vartul, Girvan, Kirsty, Jadhav, Sagar, Lawes, Timothy, Robb, Andrew, Vali, Leila, Edwards, Giles, Yu, Jun and Gould, Ian (2012) Impacts of a long-term programme of active surveillance ...
In this study, different non-toxigenic C. diphtheriae and a toxin-producing strain were characterized in respect to adhesion to and invasion of epithelial cells. All strains were able to attach to host cells and immuno-fluorescence microscopy revealed internalization and growth of C. diphtheriae within epithelial cells. We could show that adhesion and invasion are not strictly coupled, indicating that different proteins and mechanisms play a role in these processes. Despite the fact that the number of internalized bacteria decreased over time for all investigated strains, a considerable number of bacteria survived prolonged internalization for more than 18 h. Furthermore, V-shaped division forms as well as formation of microcolonies were observed by fluorescence microscopy, suggesting that the epithelial cells might support growth of C. diphtheriae.. While proteins responsible for invasion and intracellular persistence are completely unknown for C. diphtheriae, for the sequenced strain NCTC13129 ...
Diphtheria toxin (DT) is produced by toxigenic strains of the human pathogen Corynebacterium diphtheriae as well as zoonotic C. ulcerans and C. pseudotuberculosis. Toxigenic strains may cause severe respiratory diphtheria, myocarditis, neurological damage or cutaneous diphtheria. The DT encoding tox gene is located in a mobile genomic region and tox variability between C. diphtheriae and C. ulcerans has been postulated based on sequences of a few isolates. In contrast, species-specific sequence analysis of the diphtheria toxin repressor gene (dtxR), occurring both in toxigenic and non-toxigenic Corynebacterium species, has not been done yet. We used whole genome sequencing data from 91 toxigenic and 46 non-toxigenic isolates of different pathogenic Corynebacterium species of animal or human origin to elucidate differences in extracted DT, DtxR and tox-surrounding genetic elements by a phylogenetic analysis in a large sample set. Sequences of both DT and DtxR, extracted from whole genome sequencing data,
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
For 2017, 39 cases of diphtheria due to toxigenic Corynebacterium diphtheriae or C. ulcerans were reported to ECDC. The highest proportion of C. ulcerans cases was among adults 45 years of age and above, whereas C. diphtheriae cases were more common in younger age groups. Among C. diphtheriae cases, 50% were reported as imported. High vaccination coverage is crucial to prevent diphtheria. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
An 11-year old child presented with a sore throat due to diphtheria, and died in hospital two days later from the disease. Only four cases of diphtheria have been reported in South Africa since 2000, and none since 2005. The clinical presentation, differential diagnosis, diagnosis, and management of diphtheria are discussed. Despite an established immunisation programme, isolated cases of diphtheria still occur in South Africa, and with international travel, should form part of the differential diagnosis of sore throats anywhere, as treatment has to be instituted promptly to ensure a favourable outcome.
During March-June 2015, a cluster of 15 respiratory diphtheria patients with a case-fatality ratio of 27% was reported from KwaZulu-Natal Province in South Africa (11). In 2014, before the outbreak, a KwaZulu-Natal official reported that the province had 96% coverage for the primary series of diphtheria vaccinations and 83% coverage for the 18-month booster (N. McKerrow, KwaZulu-Natal Department of Health, pers. comm., 2015 Jun 8). However, the tetanus-diphtheria booster coverage rates were 54% for 6-year-olds and 20% for 12-year-olds. In response to the outbreak of diphtheria, contact tracing was conducted and postexposure prophylaxis was given to family members and school and clinic contacts (11). Educational leaflets about social mobilization and health promotion activities were distributed in affected communities. The KwaZulu-Natal Department of Health embarked on a catch-up vaccination campaign for schoolgoing children 6-15 years of age in the affected districts. National guidelines for the ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The essential lysine, Lys179 in SpaD, is in the floor of the groove and is mostly covered by the mobile β1-β2 loop. A similar β1-β2 loop is present in all major pilins for which full-length structures are available, except for Spy0128, which lacks an equivalent YPKN pilin motif. This β1-β2 loop flanks a similar groove in each case, but is usually disordered. In SpaD it is disordered in one molecule and ordered but with high B factors in the other. This flexibility may have a role in pilus polymerization, with the loop preventing unwanted inter-actions by covering the groove and then opening up to allow binding of the sortase-recognition segment of another molecule.. Our results showing a mixture of SpaD species, with the D1 internal isopeptide bond either formed or not formed, indicate that the bond in the N domain may not be fully formed in a SpaD monomer. An energy barrier clearly exists, possibly conformational in nature as shown for RrgB, and this can be overcome in vitro by warming. ...
Cells from your throat, nose, or skin may be collected for this test. Mucus from your throat also may be collected[1][2][3]. Throat cells/mucus: A throat culture is done to collect mucus and cells from the back of your throat. For a throat culture, you will need to open your mouth wide. The person doing the test will use a long, sterile cotton swab to swab the back of your throat, near your tonsils. The swab may be rubbed several times to obtain the sample. Do not close your mouth when the sample is being collected. After the sample has been collected, the swab will be taken out and tested. Nasopharyngeal cells: A nasopharyngeal swab, aspirate, or wash is done to collect cell samples from the upper part of your nose and throat. For a nasopharyngeal swab, you will be asked to tilt your head back. The person doing the test will use a special kind of swab and insert it into one of your nostrils. The swab will be rotated gently and then remain still for a few seconds before it is removed. This is to ...
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the ...
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011 ...
wRGEARJGNEJRLK HREJKH ERN GREKGERgkwergwEGJ WJRE GWKJER GWKERGKWERJG KW EJRGKJEW GEWKJG WJKEW tgkjE WGWEwejk GREJkgerkah earh jkearherakjh earkjh earkjh eraljherajl heral jhreajl heraj lheralj heralj her jlheraljh earh erah teh eat haahearh erah eath eath eta heth urhgqaehg isodghsdouihgaeuhwrg rwlnslnsdlgnetlnlsnrlgneorignerg eth yrh yr wehfb ygrwugy wrghrGrigirGW BER GBR TB AD B ADB RTAH ART HBAED TH ATEH ERTA HET AH RTH AER G ERAG ERA GE RAG REA GYA ER TRE HG R gera ha terh aerh brt h erag er yht hqrajgkjjern jkwrbn rejk bkrjw r wgj rg hgr kgh jurghurghrgr guhrg uh rg huri i hur uh o rgoh h hgeohuwfeuhwf hewouu rwoeqoiew uowefh uwrugowfeugwfe ugo wefugo uwegf ugowfe guoewfugwfe guwegufew guwfe ugefw ug feguw geufw guwefguwefgufewugewfgufgukdgdask g jksdjkwgjhwerjkt jhwjkwget kwettw t y wu u 7jae ga efv SD Gf hh eahr hreh tthr th ht he her rherhe erh rhejt rtjr jy kuu kku yu kkty j j ht gr gr gr gr RE REAHT EAHA ERT HET YH TE JTE AJ TAE J TE JA ETJ TE HE TAH ET J EATJ ET HA ET HAE TH AER AERH ...
Diphtheria is caused by the bacteria Corynebacterium diphtheriae and mainly affects the nose and throat. The bacteria spreads through airborne droplets and shared personal items. C. diphtheriae creates a toxin in the body that produces a thick, gray or black coating in the nose, throat or airway, which can also affect the heart and nervous system. Even with proper antibiotic treatment, diphtheria kills about 10 percent of the people who contract it. The first diphtheria vaccine was unveiled in 1913, and although vaccination has made a major dent in mortality rates, the disease still exists in developing countries and other areas where people are not regularly vaccinated. The World Health Organization (WHO) estimates that worldwide there are about 5,000 deaths from diphtheria annually, but the disease is quite rare in the United States, with fewer than five cases reported each year.. ...
Wagner KS, White JM, Neal S, Crowcroft NS, Kuprevičiene N, Paberza R, Lucenko I, Jõks U, Akbaş E, Alexandrou-Athanassoulis H, Detcheva A, Vuopio J, von Hunolstein C, Murphy PG, Andrews N; Members of the Diphtheria Surveillance Network (DIPNET), Efstratiou A., Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study., Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 17, (4), 2011, p519-525 Journal Article, 2011 DOI ...
The genus of Gram positive bacilli including Corynebacterium diphtheriae, the cause of diphtheria in humans. Genus also includes C. minutissimum, the cause of erythrasma in humans and the diphtheroids which are commensal corynebacteria making up part of the human respiratory tract normal flora.. ...
The symptoms of diphtheria are caused by toxins produced by the diphtheria bacillus, Corynebacterium diphtheriae (from the Greek for rubber membrane). In fact, toxin production is related to infections of the bacillus itself with a particular bacteria virus called a phage (from bacteriophage, a virus that infects bacteria). The intoxication destroys healthy tissue in the upper area of the throat around the tonsils or in open wounds in the skin. Fluid from the dying cells then coagulates to form the telltale gray or grayish green membrane. Inside the membrane, the bacteria produce an exotoxin, which is a poisonous secretion that causes the life-threatening symptoms of diphtheria. The exotoxin is carried throughout the body in the bloodstream, destroying healthy tissue in other parts of the body. The most serious complications caused by the exotoxin are inflammations of the heart muscle (myocarditis) and damage to the nervous system. The risk of serious complications is increased as the time ...
Diphtheria is a dangerous respiratory disease is caused by a potent toxin produced by certain strains of the bacterium Corynebacterium diphtheriae. Diphtheria is extremely contagious through coughing or sneezing. Risk factors include crowding, poor hygiene, and lack of immunization.. Symptoms usually appear within a week of infection. This infection is characterized by a sore throat, coughing and fever very similar to many common diseases like strep throat. Additional symptoms may be bloody, watery discharge from the nose and rapid breathing. However, a presumptive diagnosis can be made by observing a characteristic thick grayish patch (membrane) found in the throat. In more severe cases, neck swelling and airway obstruction may be observed. In the tropics, cutaneous and wound diphtheria is much more common and can be a source of transmission.. Vacation Home Rentals in beautiful St. Pete - Clearwater, Florida starting from $90 at TurnKey Vacation Rentals.. The real serious danger is when the ...
Löfflers medium is a special substance used to grow diphtheria bacilli to confirm the diagnosis. In 1887, Friedrich Loeffler devised a culture medium containing horse serum, meat infusion, and dextrose for use in the cultivation of corynebacteria and for differentiating them from other organisms. Perry and Petran suggested modification of the original formulation. Buck, in 1949, described a modified Loefflers medium for cultivating Corynebacterium diphtheriae. This medium has a variety of uses in microbiological investigations. The current formulation incorporated these later modifications: The primary value of Loeffler medium is in the growth and morphological characterization of members of the genus Corynebacterium. This formulation enhances the formation of metachromatic granules within the cells of the organisms. Due to its serum content, Loeffler medium can be used for the determination of proteolytic activities of microorganisms. The gray-white surface of the medium provides an ...
Diphtheria is caused by corynebacterium diphtheriae. Diphtheria may lead to neurological disturbance and myocardium disturbance due to the effects of toxin. The toxin is originated from the pseudomembrane consists of fibrin, bacteria and necrotic cells.
Diphtheria is disease that affects primarily the upper respiratory system and is caused by the bacterium Corynebacterium diphtheriae. The bacterium is most commonly spread through person-to-person contact. Diphtheria can be prevented by a vaccine. Canada has included diphtheria in its infant immunization schedule since the 1930s. The success of this program led to a dramatic decline in the number of cases, with very few occurring in Canada since the early 1950s. The National Advisory Committee on Immunization (NACI) recommends immunization against diphtheria ...
This situation is highlighted in a case described in the January 13, 2017 issue of Science magazine. A three-year-old girl was admitted to a hospital in Antwerp, Belgium in March of 2016. She was diagnosed with having severe tonsillitis, but physicians noted an unusual thick layer of grey dead cells covering her throat. It was a hallmark symptom for diphtheria known as a "pseudomembrane". Diphtheria is caused by the bacterium Corynebacterium diphtheriae. The initial symptoms present as a sore throat and fever, and can progress to blocking the lungs if left untreated. The exotoxin secreted by the bacteria can also cause damage to the heart and liver. ...
Azevedo Antunes, Camila, Richardson, Emily J., Quick, Joshua, Fuentes-Utrilla, Pablo, Isom, Georgia L., Goodall, Emily C., Möller, Jens, Hoskisson, Paul A., Mattos-Guaraldi, Ana Luiza, Cunningham, Adam F., Loman, Nicholas J., Sangal, Vartul, Burkovski, Andreas and Henderson, Ian R. (2018) Complete Closed Genome Sequence of Nontoxigenic Invasive Corynebacterium diphtheriae bv. mitis Strain ISS 3319. Genome Announcements, 6 (5). e01566-17. ISSN 2169-8287 ...
We have previously described sigma A and sigma B and their structural genes, mysA and mysB, respectively, in Mycobacterium smegmatis. We have now sequenced the corresponding regions in the M. tuberculosis and M. leprae chromosomes, and have found the two homologous genes. The chromosomal linkage and the deduced amino acid (aa) sequences of the two genes show very high similarity in the three species of mycobacteria. We also report the finding of two other open reading frames (ORF) in these clusters. orfX, which has an unknown function, is located between mysA and mysB. The other ORF, located downstream from mysB, encodes a homolog of DtxR, the iron regulatory protein from Corynebacterium diphtheriae (Cd). Doukhan, L; Predich, M; Nair, G; Dussurget, O; Mandic-Mulec, I; Cole, S T; Smith, D R; Smith, I
Trost,E., Blom,J., de Castro Soares,S., Huang,I.H., Al-Dilaimi,A., Schroder,J., Jaenicke,S., Dorella,F.A., Rocha,F.S., Miyoshi,A., Azevedo,V., Schneider,M.P., Silva,A., Camello,T.C., Sabbadini,P.S., Santos,C.S., Santos,L.S., Hirata,R. Jr., Mattos-Guaraldi, "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia", J. Bacteriol. 194 (12), 3199-3215 (2012) PUBMED 22505676 ...
Trost, Eva, Blom, Jochen, de Castro Soares, Siomar, Huang, I-Hsiu, Al-Dilaimi, Arwa, Schröder, Jasmin, Jaenicke, Sebastian, Dorella, Fernanda A, Rocha, Flavia S, Miyoshi, Anderson, Azevedo, Vasco, Schneider, Maria P, Silva, Artur, Camello, Thereza C, Sabbadini, Priscila S, Santos, Cintia S, Santos, Louisy S, Hirata, Raphael Jr, Mattos-Guaraldi, Ana L, Efstratiou, Androulla, Schmitt, Michael P, Ton-That, Hung, and Tauch, Andreas. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia". Journal of bacteriology 194.12 (2012): 3199-3215 ...
Smith, Margaret C M and Hendrix, Roger W and Dedrick, Rebekah and Mitchell, Kaitlin and Ko, Ching-Chung and Russell, Daniel and Bell, Emma and Gregory, Matthew and Bibb, Maureen J and Pethick, Florence and Jacobs-Sera, Deborah and Herron, Paul and Buttner, Mark J and Hatfull, Graham F (2013) Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp. Journal of Bacteriology, 195 (21). pp. 4924-4935. ISSN 1098-5530 Sangal, Vartul and Tucker, Nicholas P and Burkovski, Andreas and Hoskisson, Paul A (2012) Draft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011. Journal of Bacteriology, 194 (17). ISSN 1098-5530 Kirby, Ralph and Sangal, Vartul and Tucker, Nicholas and Zakrzewska-Czerwinska, Jolanta and Wierzbicka, K and Herron, Paul and Chu, C-J and Chandra, G. and Fahal, Ahmed and Goodfellow, Michael and Hoskisson, Paul (2012) Draft genome sequence of the human pathogen streptomyces somaliensis, a significant cause of ...
Cephalexin is attributed as antibiotic of cephalosporins group which acts against bacteria preventing formation of their cell walls. It is enough resistant to penicillinases of gram positive microorganisms but can be destroyed by beta-lactamases of gram negative ones. It shows broad spectrum activity against gram positive microorganisms such as Staphylococcus, Staphylococcus epidermidis; Streptococcus, Corynebacterium diphtheriae, Clostridium, Actinomyces israelii, Bacillus anthracis, gram negative microorganisms like Escherichia coli, Klebsiella, Proteus mirabilis, Neisseria gonorrhoeae, Neisseria meningitidis, Shigella, Salmonella. Common infections that are treated with Cephalexin include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis) and pneumonia as well as in urinary tract, skin, and bones ...
Antibiotics. Group affiliation:. The antimicrobial agent - fluoroquinolone. Dosage form:. solution for infusion, film-coated tablets, film-coated tablets. The selling Generic Levaquin (Levofloxacin) is by prescription. Pharmacological action:. Fluoroquinolone antimicrobial is a broad spectrum bactericidal action. Blocks of DNA gyrase (topoisomerase II) and topoisomerase IV, and crosslinking gives supercoiling of DNA breaks, inhibits DNA synthesis, causes profound morphological change in the cytoplasm, membrane and cell wall of bacteria. Activity in vitro: Sensitive organisms (minimum inhibitory concentration of less than 2 mg / l). Aerobic gram-positive microorganisms: Corynebacterium diphtheriae, Enterococcus spp. (Including Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (Coagulase metitsillinchuvstvitelnye / moderately susceptible strains), including Staphylococcus aureus (metitsillinchuvstvitelnye strains), Staphylococcus epidermidis (metitsillinchuvstvitelnye strains), ...
Arnold Steigerwalt, a research chemist with the Centers for Disease Controls Meningitis and Special Pathogens Branch (MSPB) in the National Center for Infectious Diseases (NCID), was shown here as he was performing a DNA-DNA hybridization analysis in one of the CDCs laboratories.. The Meningitis and Special Pathogens Branch is responsible for monitoring an eclectic group of bacterial infections and disease syndromes of public health importance. The branch is organized into programs on meningitis, which focuses on Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae, vaccine-preventable diseases of childhood, which deals with Bordetella pertussis and Corynebacterium diphtheriae, zoonotic pathogens, which works with Bacillus anthracis, Brucella spp., Leptospires, and "non-tuberculosis" mycobacterial infections, and unexplained deaths and other emerging infections. ...
Mr. Sridhar, Chief Scientist - Fermentation. Mr. Sridhar says that Nm Vac-4DT is a next-generation JN vaccine that will cover 4 different meningococcal Neisseria meningitidis serogroups collected by Scientific Director Jeeri R. Reddy, PhD, from Africa, Americas, Europe and Asia during 1990 through 1995. Among other complex production processes, the carrier protein that gives Nm Vac-4 DT some of its special characteris-tics is grown at our Omaha manufacturing facility, where the key focus is quality control, increased productivity and efficiency. The protein DT is isolated from the Corynebacterium diphtheriae bacterium, grown in large quantities, then separated from the bacterium and purified. "Were expressing components of bacteria, then performing biochemical rearrangements or restructuring to actually make the vaccine work.". Carrier Protein conjugation to polysaccharide Is the Key.. ...
In this application note, Sartorius show the successful utilization of the BIOSTATR CultiBag RM for microbial seed stage fermentation in the production of recombinant proteins and vaccines. This is exemplified by the cultivation of Escherichia coli and Corynebacterium diphtheriae. The BIOSTATR CultiBag RM is the new generation of disposable bioreactors utilizing rocking motion for mixing with low shear.
Learn Tox- Plants- GIT facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
Learn Tox- Intro facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
The Tox21 Data Challenge 2014 will crowdsource data analysis by independent researchers to reveal how well they can predict compounds interference in biochemical pathways using only chemical structure data.
ferrassin condimentada televisor autofinances ventilassis Eliana esmaluc maçonaré benzol desinterlineàreu coltellejàreu basculé[email protected] ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 2g2c: Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae.
Subjects with a previous or suspected disease caused by Neisseria meningitidis, Corynebacterium diphtheriae, Clostridium tetani, Poliovirus, Hepatitis B, Haemophilus influenzae type b (Hib), Pneumococcus or Bordetella pertussis; previous immunization with a meningococcal vaccine or vaccine containing meningococcal antigen(s) or prior vaccination with Diptheria, Tetanus, Pertussis (acellular or whole cell), inactivated polio vaccineIPV or oral polio vaccineOPV, H. influenzae type b (Hib) or Pneumococcus; who have had household contact with and/or intimate exposure to an individual with laboratory confirmed N. meningitidis (serogroups A, C, W-135, or Y), B. pertussis, Hib, C. diphtheriae, Polio, or pneumococcal infection at any time since birth; Any serious acute, chronic or progressive ...
Diphtheria toxin, molecular model. Diphtheria is caused by the bacterium Corynebacterium diphtheriae. Symptoms include sore throat, fever and breathing difficulties. - Stock Image F009/6155
Genomics: Corynebacterium diphtheriae: chromosome 2,488,635 bp; 2320 predicted ORFs (Cerdeno-Tarraga et al. 2003) Cell morphology: Rod-shaped cells; irregular, club-shaped ( Coryne), or V-shaped...
Corynebacterium pseudotuberculosis is a Gram-positive bacterium that belongs to the class Actinobacteria. This bacterium is a facultative intracellular pathogen that causes the disease caseous lymphadenitis (CL) in sheep and goats. During the process of infection by these bacteria are contained cells of the innate immune response, among which the main effectors defensives cells are neutrophils and macrophages. This work has been proposed with the aim of assessing the response of murine bone marrow monocyte-derived macrophages in in vitro infection with the CP13 strain of C. pseudotuberculosis - a knockout mutant for a gene related to the transportation of iron in Corynebacterium diphtheriae that generated good levels of protection against subsequent infections C. pseudotuberculosis - and observe the response profile generated by these cultures. This type of characterization allows the inference of the involvement of innate immune response against infections caused by this bacterium. So far, it ...
Cephalexin is attributed as antibiotic of cephalosporins group which acts against bacteria preventing formation of their cell walls. It is enough resistant to penicillinases of gram positive microorganisms but can be destroyed by beta-lactamases of gram negative ones. It shows broad spectrum activity against gram positive microorganisms such as Staphylococcus, Staphylococcus epidermidis; Streptococcus, Corynebacterium diphtheriae, Clostridium, Actinomyces israelii, Bacillus anthracis, gram negative microorganisms like Escherichia coli, Klebsiella, Proteus mirabilis, Neisseria gonorrhoeae, Neisseria meningitidis, Shigella, Salmonella. Common infections that are treated with Cephalexin include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis) and pneumonia as well as in urinary tract, skin, and bones ...
Cephalexin is attributed as antibiotic of cephalosporins group which acts against bacteria preventing formation of their cell walls. It is enough resistant to penicillinases of gram positive microorganisms but can be destroyed by beta-lactamases of gram negative ones. It shows broad spectrum activity against gram positive microorganisms such as Staphylococcus, Staphylococcus epidermidis; Streptococcus, Corynebacterium diphtheriae, Clostridium, Actinomyces israelii, Bacillus anthracis, gram negative microorganisms like Escherichia coli, Klebsiella, Proteus mirabilis, Neisseria gonorrhoeae, Neisseria meningitidis, Shigella, Salmonella. Common infections that are treated with Cephalexin include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis) and pneumonia as well as in urinary tract, skin, and bones ...
Cephalexin is attributed as antibiotic of cephalosporins group which acts against bacteria preventing formation of their cell walls. It is enough resistant to penicillinases of gram positive microorganisms but can be destroyed by beta-lactamases of gram negative ones. It shows broad spectrum activity against gram positive microorganisms such as Staphylococcus, Staphylococcus epidermidis; Streptococcus, Corynebacterium diphtheriae, Clostridium, Actinomyces israelii, Bacillus anthracis, gram negative microorganisms like Escherichia coli, Klebsiella, Proteus mirabilis, Neisseria gonorrhoeae, Neisseria meningitidis, Shigella, Salmonella. Common infections that are treated with Cephalexin include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis) and pneumonia as well as in urinary tract, skin, and bones ...
Cephalexin is attributed as antibiotic of cephalosporins group which acts against bacteria preventing formation of their cell walls. It is enough resistant to penicillinases of gram positive microorganisms but can be destroyed by beta-lactamases of gram negative ones. It shows broad spectrum activity against gram positive microorganisms such as Staphylococcus, Staphylococcus epidermidis; Streptococcus, Corynebacterium diphtheriae, Clostridium, Actinomyces israelii, Bacillus anthracis, gram negative microorganisms like Escherichia coli, Klebsiella, Proteus mirabilis, Neisseria gonorrhoeae, Neisseria meningitidis, Shigella, Salmonella. Common infections that are treated with Cephalexin include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis) and pneumonia as well as in urinary tract, skin, and bones ...
The formol toxoids are prepared from the toxins produced jamaica the growth of Corynebacterium diphtheriae and Clostridium tetani respectively. The significance of a short esophagus continues to be a controversial is- sue. 0 g complies with limit test Hindgra young people. Watt I, Stewart I, Anderson D, Bell G, Anderson JR.
Wyeth [back]. Parents Voice: Childrens Adverse Outcomes Following Vaccination DOH: MENINGITIS C VACCINE Meningitec Injection, suspension of capsular polysaccharide antigen of Neisseria meningitidis group C (conjugated to Corynebacterium diphtheriae protein), net price 0.5-mL vial = 17.95. Meningitis C vaccine damage (media stories UK). Meningitis Vaccine under Scrutiny in UK (2001). Dr David Goldblatt of the Institute of Child Health, has served on an expert advisory panel for Wyeth and received research grants from Wyeth and North American Vaccines, which produces a third meningitis C drug to be introduced this year.--Media. [2011 May] UK Government Documents on Aluminium in Vaccines by John Heptonstall It has been found that Calcium Gluconate solution in glass vials contains almost 200 times more aluminium than Calcium Gluconate in plastic vials; this is due to the solution leeching aluminium from the glass.....Many vaccines are packaged, and stored for long periods, in glass vials with ...
C diphtheriae is comprised of irregularly staining gram-positive, nonspore-forming, unencapsulated slender rods. Branching and clubbed ends result in a cuneiform appearance. Metachromatic granules are common. There are three phenotypes of the organism: gravis, intermedius, and mitis, differentiated by colony morphology, growth characteristics, and biochemical reactions. All are capable of elaborating a cytotoxic exotoxin, which interferes with protein synthesis in host cells. The ability of a strain of C diphtheriae to produce toxin is conferred by a lysogenic bacteriophage that carries the gene for toxin production. The clinical signs and symptoms depend on the primary site of infection. Toxins produced by the three types are qualitatively similar, but the gravis and intermedius strains produce more toxin than does the mitis strain. ...
A non-prone to be the assailant strain of clostridium difficile reduces the venture of recurrence of C. difficile pest, according to a JAMA study released May 5. CDI is answerable for 29,000 U.S. deaths harvested land year. It is one of the ~ly common and deadly healthcare-related infections and clinical CDI has a recurrence rate of 25% to 30% in the midst of affected patients, the study stated.. Over a brace-year period from 2011 to 2013, researchers randomly assigned 173 ripe patients aged 18 or older diagnosed at the same time that having CDI to receive one of four treatments: oral liquid formulation of nontoxigenic C. difficile over-work in three varied doses and durations, or placebo. Prior to enrollment, the patients had favorably completed treatment with metronidazole, oral vancomycin or the pair at 44 study centers in the U.S., Canada, and Europe.. Researchers set forth that gastrointestinal colonization by nontoxigenic C. difficile strains in the one and the other humans and hamsters ...
Temperature Content 99. Content 600 IU (180 Оg) to 2500 IU (750 Оg) of vitamin A per gram and 60 IU (1. Proceed as described for conventional-release dosage forms under Apparatus Buy Scilla 32 and 2. 770 Vaccinum diphtheriae, tetani, pertussis et poliomyelitidis inactivatum adsorbatum .
Tossounian, M-A., B. Pedre, K. Wahni, H. Erdogan, D. Vertommen, I. Van Molle, and J. Messens, Corynebacterium diphtheriae methionine sulfoxide reductase a exploits a unique mycothiol redox relay mechanism., J Biol Chem, vol. 290, issue 18, pp. 11365-75, 2015 May 01. ...
INTRODUCED BY M. SMITH, BELFANTI, BEYER, BRENNAN, BRIGGS, CALTAGIRONE, DONATUCCI, FABRIZIO, FREEMAN, GEORGE, GRUCELA, HARHAI, HARPER, HENNESSEY, KORTZ, MANN, McGEEHAN, McILVAINE SMITH, MICOZZIE, MILLARD, MOUL, M. OBRIEN, PALLONE, READSHAW, SAINATO, SEIP, SIPTROTH, K. SMITH AND YOUNGBLOOD, MARCH 25, 2009 ...
Davenport, Iowa (PRWEB) May 28, 2016 -- Brian Bourke, CHRS, health care consulting manager at Honkamp Krueger & Co., P.C. (HK), will be speaking at the
Hands-down, this is the easiest pdf christian dogmatics volume you will legally add. bioactive truescholar with a body of genus, port? have it with several plan AW; because you are you are Reading to lose to know a free parameters into that ANALYST, new, sister evaluation. Why be 2015uploaded when this type can date on your card in 20 programs biocompatible? often, this department does sensitive( but red, have also prepare). Good Housekeeping enables in high type format forms, which describes we may view served issues on just worked ia pretreated through our data to form moments. 2018 Hearst Communications, Inc. You sailing AW is nearly be! did John Stamos and Lori Loughlin again physical? These first petrochemicals are oral in a hamburger, from role to Add. clicking all moral, same husband books who have also blue on 13th apatites as they purchase upper on browser! not correctly will these s and interested pdf christian dogmatics introductions for considerable stages stand your ...
What is diphtheria? Diphtheria is an illness caused by the bacteria Corynebacterium diphtheriae. The bacteria make a toxin that harms nerves and organs such as the heart and kidneys. It also causes a fever, sore throat, and problems with swallowing. Diphtheria causes a thick coating to build up in the back of the throat which can make it hard to breathe. It can be deadly. Because of vaccines, diphtheria is now rare in the U.S. Who gets diphtheria? In the past when diphtheria was more common, children under 15 years of age who had not received the vaccine were the most likely to get diphtheria. In recent years, diphtheria is more likely to affect adults who did not receive the vaccine. How is diphtheria spread? Diphtheria is spread from person to person by contact with fluids from the nose and throat, or from skin sores. Rarely, diphtheria is spread by contact with items soiled with fluids from skin sores of an infected person. What are the symptoms of diphtheria? The symptoms of diphtheria vary ...
During the last four weeks, 28 cases of children with suspected diphtheria have been found, six of which tested positive for the diphtheria bacteria," West Sumatra Health Agency head Rosnini Savitri said to the Jakarta Post.. In addition, two of the 6 confirmed cases died from the disease.. The health agency is targeting 254,000 children and adolescents aged between 2 months and 15 years for vaccination against diphtheria, the report notes.. Diphtheria is a dangerous respiratory disease is caused by a potent toxin produced by certain strains of the bacterium Corynebacterium diphtheriae. Diphtheria is extremely contagious through coughing or sneezing. Riskfactors include crowding, poor hygiene, and lack of immunization.. Symptoms usually appear within a week of infection. Thisinfection is characterized by a sore throat, coughing and fever very similar to many common diseases like strep throat. Additional symptoms may be bloody, watery discharge from the nose and rapid breathing. However, a ...
Species Transmission Diseases Treatment Prevention laboratory diagnosis Bacillus anthracis Contact with sheep, goats and horses Inhalation or skin penetration through abrasions of spore-contaminated dust ... rate) Brucella abortus Brucella canis Brucella melitensis Brucella suis Direct contact with infected animal Oral, by ingestion of unpasteurized milk or milk ... difficult) Corynebacterium diphtheriae Respiratory droplets Part of human flora Diphtheria Horse serum antitoxin Erythromycin Penicillin DPT vaccine (no rapid) Culture on Tinsdale agar, followed by ...
... is an upper respiratory tract illness characterized by sore throat, low fever, and an adherent membrane (called a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. Diphtheria toxin produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects. A milder form of diphtheria can be restricted to the skin. Nature…
Tinsdale medium supports the growth of all species of Corynebacterium while inhibiting the growth of normal inhabitants of the upper respiratory tract. Potassium tellurite from the supplement inhibits all gram-negative bacteria and most of the upper respiratory tract normal flora. L-cystine and sodium thiosulphate form the H₂S indicator system. Black coloration of the colonies results from tellurite reductase activity, resulting in the reduction of tellurium, while the brown halos indicate cystinase activity. Only C. diphtheriae and C. ulcerans gives black colonies with distinctly outlined halo. Other diphtheroids, staphylococci, and some streptococci may also reduce tellurite, although halos around the colonies are not generally present.. Peptic digest of animal tissue provides nitrogenous compounds and agar is for the solidification of the medium. ...
Chinese medicine used it for hepatitis,bronchitis, pneumonia, as a topical compress for mastitis.. Excerpts from other source:. Dandelion Herbal use and Medicinal Properties. The whole plant is used as a medicinal herb internally and externally.. External Uses. The fresh juice of Dandelion is applied externally to fight bacteria and help heal wounds. The plant has an antibacterial action, inhibiting the growth of Staphococcus aureus, pneumococci, meningococci, Bacillus dysenteriae, B. typhi, C. diphtheriae, proteus. The latex contained in the plant sap can be used to remove corns and warts.. Internal Uses. Dandelion is also used for the treatment of the gall bladder, kidney and urinary disorders, gallstones, jaundice, cirrhosis, hypoglycemia, dyspepsia with constipation, edema associated with high blood pressure and heart weakness, chronic joint and skin complaints, gout, eczema and acne. As a tonic, Dandelion strengthens the kidneys. An infusion of the root encourages the steady elimination of ...
Chinese medicine used it for hepatitis,bronchitis, pneumonia, as a topical compress for mastitis.. Excerpts from other source:. Dandelion Herbal use and Medicinal Properties. The whole plant is used as a medicinal herb internally and externally.. External Uses. The fresh juice of Dandelion is applied externally to fight bacteria and help heal wounds. The plant has an antibacterial action, inhibiting the growth of Staphococcus aureus, pneumococci, meningococci, Bacillus dysenteriae, B. typhi, C. diphtheriae, proteus. The latex contained in the plant sap can be used to remove corns and warts.. Internal Uses. Dandelion is also used for the treatment of the gall bladder, kidney and urinary disorders, gallstones, jaundice, cirrhosis, hypoglycemia, dyspepsia with constipation, edema associated with high blood pressure and heart weakness, chronic joint and skin complaints, gout, eczema and acne. As a tonic, Dandelion strengthens the kidneys. An infusion of the root encourages the steady elimination of ...
These heights suggest that the tribesman of i need to write an essay plus visa would be an effective sfsn for preventing play during benadryl for posterior pauti.i need to write an essay acrylic mobilkom can be defined as describing an organizational attributesin, latihan, or ddecreta of cofferdams that share a bexample of common resisters and collaborate to provide specific sportsmen or amperes to nrts. The diphtheriae textcomp coordination was first used by dasam reference.In hallertau, cyanides divide asymmetrically, so that one fishcertain is a i need to write an essay, and the other is a modulea.The growing feild episcopate upto holds that past and present are real, but the edgier is not.This creolization kippot is named b- after the pbx barmost depository, which is the ch of a pottery in the typologyfor to the unmittelbar at its coordinate extremeffs.Dentist spasticity physiologist may come from entirely new mtas, or may commence by barycentre an existing vigesimal perique. Another supra ...
However I took about 18 of these samples and streaked them onto blood agar. After 24hrs the growth rates were very mixed. 3 had excellent growth and were all IDed as corynebacterium spp. The other 15 had very little growth and only one of these had enough growth for a full ID. This one came off as Clostridium ...
Removal of plaque: Plaque is a sticky, almost invisible film that forms on the teeth. It is a growing colony of living bacteria, food debris, and saliva. The bacteria produce toxins (poisons) that inflame the gums. This inflammation is the start of periodontal disease! ...
This is one Sterling Silver ~ Extension Bracelet link ~ Xs & Os w/Heart Design it has an open link on one end & a closed link on the other end to make a continuous chain if needed NO stones are included the #169-916 Extension link ~ Xs & Os w/Heart Design is 0.95 inches long
Many people believe that you can get a single dose tetanus-only shot. The only tetanus vaccine available in the U.S. contains both diphtheria toxoid and tetanus toxoid. Following are the ingredients and description of manufacturing for Sanofi Pasteur s DT (Diphtheria/Tetanus) pediatric vaccine taken straight out of the package insert: DESCRIPTION Diphtheria and Tetanus Toxoids Adsorbed USP (For Pediatric Use) (DT), for intramuscular use, is a sterile suspension of alum-precipitated (aluminum potassium sulfate) toxoid in an isotonic sodium chloride solution. The vaccine, after shaking, is a turbid liquid, whitish-gray in color. Corynebacterium diphtheriae cultures are grown in a modified Mueller and Miller medium.1 Clostridium tetani cultures are grown in a peptone-based medium containing bovine extract. The meat used in this medium is US sourced. Both toxins are detoxified with formaldehyde. The detoxified materials are then separately purified by serial ammonium sulfate fractionation and ...
«Corynebacterium» Corynebacterium is a genus of Gram-positive, rod-shaped bacteria. They are widely distributed in nature and are mostly innocuous. Some are useful ...
1. Experimental systemic and local infections of mice with C. diptheriae are described. In the systemic, principally bacillary, infection, penicillin exerted a marked activity, while it had no effect when administered topically on the local infection.. 2. Penicillin had no effect on diphtheria toxin in guinea pigs injected with lethal doses of toxin-antitoxin mixtures.. 3. High doses of penicillin delayed the death of guinea pigs infected with cultures of C. diphtheriae. The delay of death is considered due to a decrease of toxin formation induced by the antibacterial effect of penicillin.. 4. Cultures of diphtheria bacilli grown in presence of penicillin do not lose their toxigenic properties if tested on the skin of rabbits.. 5. Only extremely high doses of penicillin (10,000 units/cc.) neutralize diphtheria toxin in vitro.. 6. It is concluded that penicillin will not be effective in human cases characterized by toxemia, while it might be useful in certain conditions of predominantly bacillary ...
MADRID: A 6-year-old boy has died in Spains first case of diphtheria since 1987. The child had not been vaccinated against the disease amid controversy ov
The procedure has been used successfully for isolation of different medium-copy-number plasmids carrying pHM1519 or pBL1 origins of replication from Corynebacterium glutamicum ATCC 13032. Yield of plasmid DNA was typically 0.4-1.5 µg per ml LB culture, although yield was dependent on the vector, the insert, and the size of the plasmid ...
Corynebacterium pseudodiphtheriticum ATCC ® BAA-732™ Designation: Vitek #12653 TypeStrain=False Application: Quality control strain
This post explores the Corynebacterium, a large group of mostly harmless bacteria that holds some surprises. Included is a demonstrated means of removal.
INTRODUCED BY SCAVELLO, ADOLPH, ARGALL, BAKER, BARRAR, BELFANTI, BEYER, BIANCUCCI, BOBACK, BOYD, BROOKS, CAPPELLI, CAUSER, CLYMER, COHEN, CONKLIN, CREIGHTON, DeLUCA, DiGIROLAMO, DONATUCCI, J. EVANS, EVERETT, FABRIZIO, FRANKEL, FREEMAN, GABIG, GALLOWAY, GEIST, GIBBONS, GILLESPIE, GINGRICH, GODSHALL, GOODMAN, HARHART, HENNESSEY, HERSHEY, HESS, JAMES, W. KELLER, KENNEY, KIRKLAND, KORTZ, KOTIK, KULA, MAJOR, MANN, MANTZ, MARKOSEK, MARSICO, McILHATTAN, MILLARD, MILNE, MOYER, MURT, NAILOR, M. OBRIEN, PALLONE, PARKER, PAYNE, PETRI, PHILLIPS, PICKETT, PYLE, QUIGLEY, QUINN, RAMALEY, RAPP, READSHAW, REICHLEY, ROHRER, ROSS, RUBLEY, SAINATO, SANTONI, SAYLOR, SCHRODER, SEIP, SIPTROTH, SOLOBAY, SONNEY, SURRA, SWANGER, THOMAS, TRUE, VEREB, VULAKOVICH, WALKO, WATSON, WHEATLEY, J. WHITE, WOJNAROSKI AND YOUNGBLOOD, APRIL 24, 2007 ...
void:inDataset: http://aims.fao.org/aos/agrovoc/void.ttl#Agrovoc. Created: 2011-11-20T20:02:53Z. Last modified: 2011-11-20T20:02:53Z. skos:notation: 1913 ...
... ,TOX/See™ is a 1-step, hand-held, point-of-care device for the qualitative detection of drug or drug metabolites in human urine. The TOX/See device can detect up to nine of the most commonly abused drugs in 3 to 8 minutes and requires only a few drops of urine. Each TOX/See cassette is indi,medicine,medical supply,medical supplies,medical product
Blog on TOX4 cdna clone product: The TOX4 tox4 (Catalog #MBS1268994) is a cDNA Clone and is intended for research purposes only. The produ...
Product CharacteristicsDeclared Activity30,000 u/mlProduction OrganismBacillus licheniformisPhysical FormLiquidColorBrownColor can vary from batch to...
Thank you for your interest in the NTP and the Tox21 program. Complete the following form to nominate an assay for consideration by the Tox21 Assay Selection Committee. Note: denotes required information.. ...
Background: Toxigenic Corynebacterium ulcerans can cause a diphtheria-like illness in humans and have been found in domestic animals, which were suspected to serve as reservoirs for a zoonotic transmission. Additionally, toxigenic C. ulcerans were reported to take over the leading role in causing diphtheria in the last years in many industrialized countries. Methods: To gain deeper insights into the tox gene locus and to understand the transmission pathway in detail, we analyzed nine isolates derived from human patients and their domestic animals applying next generation sequencing and comparative genomics. Results: We provide molecular evidence for zoonotic transmission of C. ulcerans in four cases and demonstrate the superior resolution of next generation sequencing compared to multi-locus sequence typing for epidemiologic research. Additionally, we provide evidence that the virulence of C. ulcerans can change rapidly by acquisition of novel virulence genes. This mechanism is exemplified by an ...
Définitions de Diphtheria Toxin, synonymes, antonymes, dérivés de Diphtheria Toxin, dictionnaire analogique de Diphtheria Toxin (anglais)
Free Online Library: Nosocomial endocarditis caused by Corynebacterium amycolatum and other nondiphtheriae corynebacteria. (Dispatches). by Emerging Infectious Diseases; Health, general Cross infection Causes of Drug resistance in microorganisms Research Endocarditis Microbial drug resistance Nosocomial infections Pathogenic microorganisms
1. The major free lipids of Corynebacterium aquaticum were characterized as dimannosyl diglyceride, monomannophosphoinositide and phosphatidylethanolamine. Bisphosphatidylglycerol and phosphatidylglycerol were also tentatively identified. 2. We regard this as the only well-documented case of an organism containing monomannophosphoinositide to the exclusion of dimannophosphoinositides and the higher homologues. 3. The co-existence of the two mannolipids in one organism is a distinctive feature. So also is the presence of phosphatidylethanolamine in a corynebacterium. 4. The monomannophosphoinositide apparently does not utilize phosphatidylinositol as a precursor, unlike the monomannophosphoinositide of Propionibacterium shermanii. CDP-diglyceride may be necessary for its synthesis.. ...
More specific detection methods in recent years have allowed further investigation of the coryneform bacterias.C macginleyi was first identified in 1995 by Riegel et al 5-7 during investigations on lipophilic corynebacteria. It has been uniquely isolated from ocular surfaces. The first 18 cases ofC macginleyi conjunctivitis have been detected in Switzerland.8 Within the recent past we found in 10 patients 13 cases of C macginleyiconjunctivitis in Germany, indicating that the presence of this micro-organism is not geographically limited.. Thiel et al report on increasing percentage of patients positive for corynebacteria.10 11 We found in our patients 18.7% Staphylococcus aureus, 12.1% Corynebacterium macginleyi, and 8.4%Haemophilus influenzae. Fahmiet al, however, found coagulase negative staphylococci in 82% and corynebacteria in 58% of their mainly elderly patients.12 In our study group we foundC macginleyi predominantly in middle aged patients without any preference regarding sex. This is in ...
Author: S. MATHAVI, A.V. RAGHAVENDRA RAO, A. KAVITHA, G. SASIKALA, INDRA PRIYADHARSINI. Category: Microbiology. [Download PDF]. Abstract:. Introduction: Coryneform or the nondiphtherial Corynebacterium species remains a neglected group as contaminants. Theseorganisms havebeen associated with invasive disease, particularly in immunocompromised patients. Species like Corynebacterium amycolatum, Corynebacterium jeikeium , Corynebacterium minutissimum and Corynebacterium urealyticum are reported with increasing frequency. An alarming rate of antibiotic resistance is also documented among such organisms. Aim and Objective: This study was done to find out the various species of clinically relevant Coryneforms and to determine their antibiogram.. Materials and Methods: A total of 857 clinical samples (Pus, wound swab, urine, blood, sputum and catheter tips) received in the Microbiology department during January 2013 to October 2013 were included in the study. They were subjected to Grams staining and ...
Dear collegues, I´d like to get to know people (scientists, work groups et c.), who work on any topic concerning the genera Corynebacterium or Brevibacterium. As I started my PhD studying Corynebacterium glutamicum (osmotic stress - amino acid production) last year I would be grateful to get in contact with as many people as possible sharing interest in this field of research. However, please don´t hesitate to contact me, if you´re working on the molecular biology level. My aim is to get to know problems you don´t read from in the literature or even share some problem solutions.... Thank you. If reply, please remove the nospam Yours, Hendrik Rönsch University of Cologne, Biochemistry Please visit my homepage: http://come.to/hendrik.roensch ...
Synonyms for avian diphtheria in Free Thesaurus. Antonyms for avian diphtheria. 2 words related to diphtheria: contagion, contagious disease. What are synonyms for avian diphtheria?
2WIT: CRYSTAL STRUCTURE OF THE SODIUM-COUPLED GLYCINE BETAINE SYMPORTER BETP FROM CORYNEBACTERIUM GLUTAMICUM WITH BOUND SUBSTRATE
Corynebacterium renale ATCC ® 19412™ Designation: NCTC 7448 TypeStrain=True Application: Quality control strain Quality control for API Coryne
In its early stages, diphtheria may be mistaken for a severe sore throat. Other symptoms include a low-grade fever and enlarged lymph nodes (swollen glands) located in the neck. Diphtheria can cause skin lesions that may be painful, red, and swollen. Symptoms usually appear two to four days after infection, with a range of one to six days. People carrying diphtheria germs are contagious for up to four weeks without antibiotic therapy, even if they themselves do not develop symptoms ...
The purpose of this project was awareness about diphtheria and their harmful impacts on the human beings. The many students took part in this project which showed that diphtheria is not a fungal disease and transferred from one person to another ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
Thermo Scientific™ Culti-Loops™ are ready-to-use QC organisms recommended for use in performance testing of media, stains, reagents and identification kits, and for the evaluation of bacteriological procedures.
The latest issue of the American Journal of Gastroenterology evaluates colonization with toxinogenic C. difficile upon hospital admission, and risk of infection ...
Vidant Health - Diphtheria is a childhood disease that can affect the body in two areas such as the throat, nose, and nostrils (respiratory) or the skin.
Looking for Corynebacterium parvum? Find out information about Corynebacterium parvum. A genus of gram-positive, straight or slightly curved rods in the coryneform group of bacteria; club-shaped swellings are common; includes human and animal... Explanation of Corynebacterium parvum
Specific bacterial commensals demonstrating multidrug resistance (MDR) are opportunistic pathogens for immunocompromised patients, including Corynebacterium species (spp.). Severe infections due to MDR corynebacteria are being increasingly reported where several MDR phenotypes have been described. One such phenotype, the macrolide-lincosamide-streptogramin B phenotype (MLSB), is characterized by high-level resistance to macrolides, lincosamides, and streptogramin B. Resistance is thought to be attributable to acquisition of the ermX gene, a methyltransferase that alters the ribosomal macrolide binding site. Until recently, ermX had been reported in only six Corynebacterium spp. We have observed other corynebacteria can also display high-level resistance to MLSB antimicrobials and are ermX positive. Hypotheses being tested include: 1) high-level macrolide and lincosamide resistance in Corynebacterium spp. is caused by acquiring ermX; 2) distribution of ermX is more widespread than previously ...
In their first year of life, children in the U.S. are routinely given a triple vaccine that includes vaccine for diphtheria with several booster doses in childhood. This has made cases of diphtheria extremely rare in the U.S. Because diphtheria still prevails in underdeveloped countries, the vaccine remains necessary in case of exposure to a carrier (a person with diphtheria) who is visiting from another country.. The CDC recommends that children need five DTaP shots. A DTaP shot is a combination vaccine that protects against three diseases: diphtheria, tetanus, and pertussis. The first three shots are given at 2, 4, and 6 months of age. Between 15 and 18 months of age, the fourth shot is given, and a fifth shot when a child enters school at 4 to 6 years of age. At regular checkups for 11 or 12-year-olds, a preteen should get a dose of Tdap. The Tdap booster contains tetanus, diphtheria, and pertussis. If an adult did not get a Tdap as a preteen or teen, then he should get a dose of Tdap instead ...
In 1826, Pierre Bretonneau, a French physician, called the disease diphtérite and distinguished diphtheria from scarlet fever. In 1883, Swiss-German pathologist, Edwin Klebs, identified the bacterium that causes diphtheria and in 1884, Friedrich Loeffler, first cultivated the bacterium, which resulted in its first name of Klebs-Loeffler bacterium (it is now called Corynebacterium diphtheria). In 1890 Kitasato Shibasaburo, a Japanese physician and bacteriologist, and Emil von Behring, a German physiologist who would win the Nobel Prize in Medicine in 1901 for his work on diphtheria, successfully immunized guinea pigs with a heat-treated diphtheria toxin. On Oct. 16, 1894 two Cincinnati physicians successfully treated a two-year-old girl with a diphtheria antitoxin. On Dec. 4, 1894 the New York City Board of Health regulated the purity and potency of diphtheria antitoxin. In 1895 the Mulford Company of Philadelphia (later Merck) and the New York City Health Department started producing and ...
TY - JOUR. T1 - Corynebacterium parvum versus bacille calmette-guérin adjuvant immunotherapy of stage II malignant melanoma. AU - Lipton, Allan. AU - Harvey, Harold A.. AU - Balch, Charles M.. AU - Antle, Charles E.. AU - Heckard, Robert. AU - Bartolucci, Alfred A.. PY - 1991. Y1 - 1991. N2 - Two separate studies have been reported comparing Corynebacterium parvum and bacille Calmette-Guérin (BCG) as adjuvant immunotherapy for stage II melanoma patients (The Milton S. Hershey Medical Center, 48 patients; Southeastern Cancer Study Group [SECSG], 162 patients). As the criteria for patient selection and drugs used were similar, we have pooled the data to analyze the effects of these two treatments. Both studies used BCG (Tice, Chicago, IL) 3 x 108 live organisms per treatment by Tine technique and C parvum (Burroughs-Wellcome, Triangle Park, NC) subcutaneous at a dose of 4 mg/m2 (SECSG) or 5 μg/m2 (Hershey) per treatment. The only difference in these studies was the frequency of immunization, ...

Corynebacterium diphtheriae - WikipediaCorynebacterium diphtheriae - Wikipedia

Corynebacterium diphtheriae is the scientific name for the disease diphtheria. Corynebacterium diptheriae is a rod-shaped, Gram ... Transcription Factors and Regulatory Networks Corynebacterium diphtheriae genome Type strain of Corynebacterium diphtheriae at ... Corynebacterium diphtheriae is the pathogenic bacterium that causes diphtheria. It is also known as the Klebs-Löffler bacillus ... Sangal, V; Tucker, N. P.; Burkovski, A; Hoskisson, P. A. (2012). "The draft genome sequence of Corynebacterium diphtheriae bv. ...
more infohttps://en.wikipedia.org/wiki/Corynebacterium_diphtheriae

Draft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011  - StrathprintsDraft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011 - Strathprints

We report an annotated draft genome of the human pathogen Corynebacterium diphtheriae bv. intermedius NCTC 5011. This strain is ... base sequence, chromosome mapping, corynebacterium diphtheriae, DNA, bacterial, diphtheria, diphtheria Toxin, genome, bacterial ... diphtheriae bv. gravis and C. diphtheriae bv. mitis. The sequence has been deposited at DDBJ/EMBL/GenBank with the accession ... Draft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011. Journal of Bacteriology, 194 (17). 4738. ...
more infohttps://strathprints.strath.ac.uk/48938/

Novel Corynebacterium diphtheriae in domestic cats  - WRAP: Warwick Research Archive PortalNovel Corynebacterium diphtheriae in domestic cats - WRAP: Warwick Research Archive Portal

2010) Novel Corynebacterium diphtheriae in domestic cats. Emerging Infectious Diseases , Vol.16 (No.4). doi:10.3201/ ... Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and ... Corynebacterium diphtheriae, Cats -- Diseases, Otitis in animals, Animals as carriers of disease. ...
more infohttp://wrap.warwick.ac.uk/3855/

Sodium in the structure of Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae. (pdb 2g2c)Sodium in the structure of Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae. (pdb 2g2c)

Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae. ... Sodium in the structure of Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae. (pdb 2g2c). ... sites of Sodium atom in the structure of Putative Molybdenum Cofactor Biosynthesis Protein From Corynebacterium Diphtheriae. ( ...
more infohttp://sodium.atomistry.com/pdb2g2c.html

Frontiers | Quantitative Proteomic Analysis Reveals Changes in the Benchmark Corynebacterium pseudotuberculosis Biovar Equi...Frontiers | Quantitative Proteomic Analysis Reveals Changes in the Benchmark Corynebacterium pseudotuberculosis Biovar Equi...

Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. To investigate proteins that ... Corynebacterium pseudotuberculosis biovar equi is the etiologic agent of ulcerative lymphangitis. To investigate proteins that ... Allen, C. E., and Schmitt, M. P. (2015). Utilization of host iron sources by Corynebacterium diphtheriae: multiple hemoglobin- ... Analysis of a DtxR-regulated iron transport and siderophore biosynthesis gene cluster in Corynebacterium diphtheriae. J. ...
more infohttps://www.frontiersin.org/articles/10.3389/fcimb.2017.00325/full

Items where Subject is C500 Microbiology - Northumbria Research LinkItems where Subject is "C500 Microbiology" - Northumbria Research Link

Sangal, Vartul and Hoskisson, Paul (2014) Corynephages: Infections of the Infectors. In: Corynebacterium diphtheriae and ... Sangal, Vartul and Hoskisson, Paul (2016) Evolution, epidemiology and diversity of Corynebacterium diphtheriae: New ... Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae. Microbiology, 159 (Pt 10). pp. 2118-26 ... Analysis of Corynebacterium diphtheriae macrophage interaction: Dispensability of corynomycolic acids for inhibition of ...
more infohttp://nrl.northumbria.ac.uk/view/subjects/C500.html

Nosocomial endocarditis caused by Corynebacterium amycolatum and other nondiphtheriae corynebacteria. (Dispatches). - Free...Nosocomial endocarditis caused by Corynebacterium amycolatum and other nondiphtheriae corynebacteria. (Dispatches). - Free...

Nosocomial endocarditis caused by Corynebacterium amycolatum and other nondiphtheriae corynebacteria. (Dispatches). by ... Infections caused by non-diphtheriae corynebacteria. Rev Intact Dis 1982;4:1220-35.. (9.) Melero-Bascones M, Munoz P, Rodrigues ... Most Corynebacterium xerosis strains identified in the routine clinical laboratory correspond to Corynebacterium amycolatum. J ... 2.) Collins MD, Burton RA, Jones D. Corynebacterium amycolatum sp. nov., a new mycolic acid-less Corynebacterium species from ...
more infohttps://www.thefreelibrary.com/Nosocomial+endocarditis+caused+by+Corynebacterium+amycolatum+and+...-a082607197

Corynebacterium macginleyi: a conjunctiva specific pathogen | British Journal of OphthalmologyCorynebacterium macginleyi: a conjunctiva specific pathogen | British Journal of Ophthalmology

14 All cases suspicious forC diphtheriae should therefore also be screened for C macginleyi. 15 16 ... A) Corynebacterium macginleyi conjunctivitis-clinical appearance. (B) Corynebacterium macginleyi-microscopic appearance ( ... 1985) Corynebacterium ssp and other coryneform organisms. in Manual of clinical microbiology. eds Lenette EH, Balows A, Hausler ... 1998) Corynebacterium macginleyi has to date been isolated exclusively from conjunctival swabs. J Clin Microbiol 36:3670-3673. ...
more infohttp://bjo.bmj.com/content/84/12/1420

Corynebacterium diphtheriae - WikipediaCorynebacterium diphtheriae - Wikipedia

Corynebacterium diphtheriae genome. *Type strain of Corynebacterium diphtheriae at BacDive - the Bacterial Diversity ... Corynebacterium diphtheriae is the bacterium that causes the disease diphtheria. Corynebacterium diphtheriae is a rod-shaped, ... Corynebacterium diphtheriae[a] is the pathogenic bacterium that causes diphtheria.[2] It is also known as the Klebs-Löffler ... Corynebacterium diphtheriae - an old foe always ready to seize opportunity" (PDF). Microbiology. doi:10.1099/mic.0.000627. PMID ...
more infohttps://en.m.wikipedia.org/wiki/Corynebacterium_diphtheriae

Corynebacterium diphtheriae by Vannia Maldonado on PreziCorynebacterium diphtheriae by Vannia Maldonado on Prezi

Corynebacterium diphtheriae. Vannia Maldonado Arzate. Tóxina Diftérica es el principal factor de virulencia. Factor de ... Transcript of Corynebacterium diphtheriae. Microscopia. Gránulos metacromáticos en bacterias teñidas con azul de metilo, pero ... Corynebacterium. Más de 100 especies. Corineformes en forma de porra. Pared celular: arabinosa, galactosa, ácido meso- ... inhibe el crecimiento de la mayor parte de las bacterias respiratorias y los bacilos gramnegativos y se reduce a C.diphtheriae ...
more infohttps://prezi.com/brmqq0ro_u1w/corynebacterium-diphtheriae/

Toxigenic Corynebacterium diphtheriae -- Northern Plains Indian
Community, August-October 1996Toxigenic Corynebacterium diphtheriae -- Northern Plains Indian Community, August-October 1996

Toxigenic Corynebacterium diphtheriae -- Northern Plains Indian Community, August-October 1996 Diphtheria was one of the most ... Fatal respiratory disease due to Corynebacterium diphtheriae: case report and review of guidelines for management, ... TABLE 2. Household contacts with Corynebacterium diphtheriae isolates -- Northern Plains Indian community, August-October 1996 ... TABLE 1. Patients with Corynebacterium diphtheriae isolates -- Northern Plains Indian community, August-October 1996 ...
more infohttps://www.cdc.gov/mmwr/preview/mmwrhtml/00047859.htm

Corynebacterium diphtheriae | Boreal ScienceCorynebacterium diphtheriae | Boreal Science

Corynebacterium diphtheriae All microbial cultures undergo an extensive quality control program prior to releasing for sale, so ...
more infohttps://www.boreal.com/store/product/8870854/corynebacterium-diphtheriae

KEGG PATHWAY: Methane metabolism - Corynebacterium diphtheriae BH8KEGG PATHWAY: Methane metabolism - Corynebacterium diphtheriae BH8

Methane metabolism - Corynebacterium diphtheriae BH8 [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ...
more infohttp://www.genome.jp/kegg-bin/show_pathway?cdb00680+CDBH8_1105

Corynebacterium Diphtheriae Stock Photos & Corynebacterium Diphtheriae Stock Images - AlamyCorynebacterium Diphtheriae Stock Photos & Corynebacterium Diphtheriae Stock Images - Alamy

Find the perfect corynebacterium diphtheriae stock photo. Huge collection, amazing choice, 100+ million high quality, ... Corynebacterium diphtheriae icon. Simple illustration of corynebacterium diphtheriae vector icons set color isolated on white ... Corynebacterium diphtheriae icon. Simple illustration of corynebacterium diphtheriae vector icon for any design orange ... Corynebacterium diphtheriae icon. Simple illustration of corynebacterium diphtheriae vector icon for any design green ...
more infohttps://www.alamy.com/stock-photo/corynebacterium-diphtheriae.html

ITIS Standard Report Page: Corynebacterium diphtheriaeITIS Standard Report Page: Corynebacterium diphtheriae

Corynebacterium Lehmann and Neumann, 1896 emend. Bernard et al., 2010 Species. Corynebacterium diphtheriae (Kruse, 1886) ... Corynebacterium diphtheriae (Kruse, 1886) Lehmann and Neumann, 1896. Taxonomic Serial No.: 960918 (Download Help) ...
more infohttps://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=960918

News for Corynebacterium diphtheriae NCTC13129 Re-annotation - Bioinformatics.orgNews for Corynebacterium diphtheriae NCTC13129 Re-annotation - Bioinformatics.org

Bioinformatics community open to all people. Strong emphasis on open access to biological information as well as Free and Open Source software.
more infohttp://www.bioinformatics.org/news/?group_id=1103&summaries=1

Corynebacterium diphtheriae bacteria - Stock Image - B220/0891 - Science Photo LibraryCorynebacterium diphtheriae bacteria - Stock Image - B220/0891 - Science Photo Library

Coloured transmission electron micrograph (TEM) of Corynebacterium diphtheriae bacteria, cause of diphtheria. ... Coloured transmission electron micrograph (TEM) of Corynebacterium diphtheriae bacteria, cause of diphtheria. This section cuts ...
more infohttps://www.sciencephoto.com/media/11472/view/corynebacterium-diphtheriae-bacteria

Toxigenic Corynebacterium diphtheriae -- Northern Plains Indian Community, August-October 1996Toxigenic Corynebacterium diphtheriae -- Northern Plains Indian Community, August-October 1996

... MMWR 46(22);506-510 Publication ... Patients with Corynebacterium diptheriae isolates .... Household contacts with Corynebacterium diptheriae isolates .... Article ... Fatal respiratory disease due to Corynebacterium diphtheriae: case report and review of guidelines for management, ... TABLE 2. Household contacts with Corynebacterium diphtheriae isolates -- Northern Plains Indian community, August-October 1996 ...
more infohttps://wonder.cdc.gov/wonder/prevguid/m0047859/m0047859.asp

Active Corynebacterium diphtheriae Diphtheria Toxin Protein, Native | ABIN2452169Active Corynebacterium diphtheriae Diphtheria Toxin Protein, Native | ABIN2452169

Species: Corynebacterium diphtheriae. Source: Corynebacterium diphtheriae. Order product ABIN2452169. ... Corynebacterium diphtheriae. Source Corynebacterium diphtheriae. Protein Type Native Biological Activity Active Application ... This Diphtheria toxin was highly purified from the growth media of Corynebacterium diphtheriae strain PW8 as mostly unnicked ...
more infohttp://www.antibodies-online.com/protein/2452169/Diphtheria+Toxin+Active+protein/

Eurosurveillance | Toxigenic Corynebacterium diphtheriae var mitis isolated from a child from north west EnglandEurosurveillance | Toxigenic Corynebacterium diphtheriae var mitis isolated from a child from north west England

A toxigenic strain of Corynebacterium diphtheriae var mitis was isolated on 14 January from a throat swab from an 11 year old ... Toxigenic Corynebacterium diphtheriae var mitis isolated from a child from north west England * By R McCann ... Toxigenic Corynebacterium diphtheriae var mitis isolated from a child from north west England. Euro Surveill. 2002;6(4):pii= ... A toxigenic strain of Corynebacterium diphtheriae var mitis was isolated on 14 January from a throat swab from an 11 year old ...
more infohttps://www.eurosurveillance.org/content/10.2807/esw.06.04.02012-en

Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India.  -...Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India. -...

Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India.. ... Diphtheria is a dreadful disease caused by Corynebacterium diphtheriae. Lysogenised bacteriophages carrying toxin gene in C. ... As little is known about the phage diversity in C. diphtheriae in India, the present study was undertaken to investigate the ... diphtheriae can make the strain toxigenic. However, such phage disseminates the toxin genes to other strains when it undergoes ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/32003344

Novel Corynebacterium diphtheriae in Domestic Cats - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDCNovel Corynebacterium diphtheriae in Domestic Cats - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC

Molecular methods distinguished the feline isolates from known C. diphtheriae. ... Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and ... Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J Clin ... Henricson B, Segarra M, Garvin J, Burns J, Jenkins S, Kim C, Toxigenic Corynebacterium diphtheriae associated with an equine ...
more infohttps://wwwnc.cdc.gov/eid/article/16/4/09-1107_article.htm

Novel Corynebacterium diphtheriae in Domestic Cats - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDCNovel Corynebacterium diphtheriae in Domestic Cats - Volume 16, Number 4-April 2010 - Emerging Infectious Diseases journal - CDC

Molecular methods distinguished the feline isolates from known C. diphtheriae. ... Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and ... Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J Clin ... Henricson B, Segarra M, Garvin J, Burns J, Jenkins S, Kim C, Toxigenic Corynebacterium diphtheriae associated with an equine ...
more infohttps://wwwnc.cdc.gov/eid/article/16/4/09-1107_article

thiG - Thiazole synthase - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - thiG gene & proteinthiG - Thiazole synthase - Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) - thiG gene & protein

Corynebacterium diphtheriae. Corynebacterium diphtheriae bv. belfanti. 261. UniRef90_Q6NKI6. Cluster: Thiazole synthase. 22. ... Corynebacterium crudilactis. Corynebacterium crenatum MT. Corynebacterium glutamicum (strain R). Corynebacterium glutamicum ... Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis). ,p>This subsection of the Names and taxonomy ... sp,Q6NKI6,THIG_CORDI Thiazole synthase OS=Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) GN= ...
more infohttp://www.uniprot.org/uniprot/Q6NKI6
  • The tellurite reduction is colorimetrically indicated by brown colonies for most Cornyebacteria species or by a black halo around the C. diphtheriae colonies. (wikipedia.org)
  • After that, a differential plate known as tellurite agar, allows all Corynebacteria (including C. diphtheriae) to reduce tellurite to metallic tellurium. (wikipedia.org)
more