Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Games, Experimental: Games designed to provide information on hypotheses, policies, procedures, or strategies.Punishment: The application of an unpleasant stimulus or penalty for the purpose of eliminating or correcting undesirable behavior.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.Thyroid (USP): A dehydrated extract of thyroid glands from domesticated animals. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.Xerostomia: Decreased salivary flow.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Submandibular Gland: One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)Adrenal Gland Diseases: Pathological processes of the ADRENAL GLANDS.Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.Fludrocortisone: A synthetic mineralocorticoid with anti-inflammatory activity.Mineralocorticoids: A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Adrenal Cortex HormonesCortodoxone: 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Wound Healing: Restoration of integrity to traumatized tissue.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Polysorbates: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.SqualeneOils: Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)Fatty Alcohols: Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Emollients: Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.Waxes: A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)Short-Wave Therapy: The use of focused short radio waves to produce local hyperthermia in an injured person or diseased body area.Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Equipment and Supplies: Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Equipment Safety: Freedom of equipment from actual or potential hazards.Medical Device Legislation: Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.DNA-Directed RNA Polymerases: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.DNA-Directed DNA Polymerase: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.DNA Replication: The process by which a DNA molecule is duplicated.

A radioimmunoassay for human plasma corticosterone. (1/79)

A radioimmunoassay for human plasma corticosterone has been developed. Antiserum against corticosterone was produced in rabbits immunized with corticosterone-21-hemisuccinate conjugated to bovine serum albumin. The antiserum cross-reacted with progesterone, DOC and dehydrocorticosterone more than 20%. After the extraction with ether, and the separation by Sephadex LH-20 microcolumn chromatography, recovery was 51.2 +/- 12.1% in 50 assays. The mean coefficient of variation between assays was 7.7% and within assays was 8.6%. Human plasma corticosterone is measured readily by assaying aliquots of an ether extract of 0.05 to 0.1 ml of plasma after microcolumn chromatography. The mean plasma corticosterone concentration at 9 a.m. was 7.1 +/- 3.2 ng/ml in 45 normal subjects. Plasma corticosterone increased 5.2 times as much as basal values after ACTH injection, whereas radioimmunoassayed cortisol increased 2.4 times. On the other hand, plasma corticosterone decreased to 22.6% of basal values at four hours after 1 mg dexamethasone, whereas radioimmunoassayed cortisol decreased to 12.3% of basal values.  (+info)

Radioimmunoassay for 11-deoxycortisol using iodine-labeled tracer. (2/79)

A simple and sensitive radioimmunoassay for 11-deoxycortisol was developed. The antiserum produced in rabbits by immunizing with a complex of 11-deoxycortisol-3-oxime and bovine serum albumin (BSA) has little cross-reactivity with other endogenous steroids. The immunoassay procedure requires only one-step ethanol denaturation of binding proteins in plasma and extraction by an organic solvent can be omitted. Furthermore, use of 125I-labeled tracer significantly simplify the counting procedure. The method is sensitive enough to detect 1 microng/100 ml of 11-deoxycortisol. Plasma 11-deoxycortisol levels measured by this method after the administration of a single dose of metyrapone ranged from 5.0 to 19.2 microng/100 ml, whereas they were 0 to 4.0 microng/100 ml in hypopituitary patients. It is concluded that this simple method is useful for the routine assay of plasma 11-deoxycortisol as a parameter of the metyrapone tests.  (+info)

Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis. (3/79)

The specificity for 11-deoxycortisol (11-DOC) of a monoclonal antibody (mAb), designated SCET, was changed to specificity for cortisol (CS) by site-specific mutagenesis followed by random mutagenesis. The Fab form of SCET was expressed on the surface of a phage. During the first step, mutations were introduced at 14 amino acid positions in three complementarity-determining regions (CDRs) of the VH domain that seemed likely to form the steroid-binding pocket. A clone, DcC16, was isolated from the resultant library with multiple mutations and this clone was shown to have CS-binding activity but also to retain high 11-DOC-binding activity. During the second step, mutations were introduced randomly into the entire VH-coding region of the DcC16 clone by an error-prone polymerase chain reaction, and CS-specific mutant antibodies were selected in the presence of 11-DOC as a competitor. Three representative clones were analyzed with the BIAcore instrument, and each revealed a large increase in the binding constant for CS and a decrease in that for 11-DOC. Structural models, constructed by computer simulation, indicated the probable molecular basis for these changes in specificity.  (+info)

Apparent activities of 21-hydroxylase, 17alpha-hydroxylase and 17,20-lyase are impaired in adrenal incidentalomas. (4/79)

OBJECTIVE: An increased response of 17-hydroxyprogesterone to ACTH stimulation has been observed in adrenal incidentaloma and linked to an impairment of either 21-hydroxylase or of 11beta-hydroxylase activity. To analyse this question further, we investigated the steroidogenic pathways in a series of 17 adrenal incidentalomas. DESIGN AND PATIENTS: 17 patients (7 women, 10 men; mean age, 62 +/- 12 years) with non-histologically analyzed adrenal incidentalomas were prospectively evaluated. METHODS: The following variables were investigated: 24-h urinary methanephrines and free cortisol excretion; plasma levels of ACTH and dehydroepiandrosterone; overnight dexamethasone suppression test; 1-24 ACTH stimulation test with measurement of: cortisol, 11-deoxycortisol, 17-hydroxyprogesterone, aldosterone, 11-deoxycorticosterone, progesterone, 17-hydroxypregnenolone, Delta4-androstenedione, dehydroepiandrosterone and 21-deoxycortisol. RESULTS: Discordant features of subclinical hypercorticism were noted in one case. No patient had dehydroepiandrosterone sulfate levels in the normal range for his or her age. Peak 17-hydroxyprogesterone and peak 21-deoxycortisol disclosed impairment of 21-hydroxylase in 11 and 10 cases respectively. An increased 11-deoxycortisol/cortisol ratio identified reduced activity of 11beta-hydroxylase in 11 patients. Eight patients displayed features of mild 17,20-lyase impairment, which was related to 21-hydroxylase dysfunction. Whereas only 2 patients showed no enzyme modification, 9 displayed alterations of at least two pathways. CONCLUSION: In our hands, a combination of enzyme dysfunction was frequently observed. Shared biochemical mechanisms could explain combined 17,20-lyase and 21-hydroxylase alterations, whereas coexistence of 21-hydroxylase (particularly when based on peak 21-deoxycortisol) and 11beta-hydroxylase is more puzzling.  (+info)

Effects of insulin-like growth factor-I on in vitro final oocyte maturation and ovarian steroidogenesis in striped bass, Morone saxatilis. (5/79)

Recombinant human (rh) insulin-like growth factor-I (IGF-I) was more potent than rhIGF-II at inducing in vitro germinal vesicle breakdown (GVBD), a marker for resumption of meiosis, in oocytes of striped bass. Treatment of ovarian fragments containing oocytes in intact follicles with rhIGF-I increased concentrations of estradiol-17beta and maturation-inducing steroid (MIS) 17,20beta, 21-trihydoxy-4-pregnen-3-one (20beta-S) in the culture medium and decreased testosterone levels. The follicles were too immature for oocytes to complete GVBD in response to 20beta-S (MIS incompetent) or hCG. Addition of 20beta-S to cultures did not increase the percentage of oocytes completing GVBD in response to rhIGF-I or rhIGF-II. Bovine insulin was without effect on GVBD or steroid production. Incubation of MIS-competent follicles with actinomycin D, cyanoketone, trilostane, 1-heptanol, or 1-octanol had no effect on rhIGF-I-induced GVBD, but attenuated hCG-induced GVBD and 20beta-S production. Cycloheximide inhibited rhIGF-I-induced GVBD. Collectively, these observations indicate that IGF-I can induce GVBD via MIS- and transcription-independent pathways without coupled gap junctions between oocytes and granulosa cells or among granulosa cells, but requires protein synthesis to do so. An rhIGF-I analogue that does not bind IGF-binding proteins, des(1,3)IGF-I, was more potent than rhIGF-I in inducing GVBD, suggesting ovarian IGF-binding proteins may inhibit IGF-I action.  (+info)

Nonchromatographic radioimmunoassay of plasma 11-deoxycortisol, for use in the metyrapone test, with polyethylene glycol as the precipant. (6/79)

We have developed a simple, reliable radioimmunoassay for plasma 11-deoxycortisol. The method does not require chromatography but instead makes use of a simple extraction procedure which, in combination with the antibody characteristics, is highly specific for the metyrapone test. Polyethylene glycol was used to separate free and antibody-bound steroid. The smallest amount measurable is 15 pg (2.0 mug/liter of plasma). The method is shown to be precise and accurate. Intraassay precision of the method for two plasma pools was 26.7 plus or minus 2.5 mug/liter (CV equals 9.4%) and 61.2 plus or minus 3.7 mug/liter (CV equals 6.0%). The respective inter-assay precision was 27.0 plus or minus 1.7 mug/liter (CV equals 6.3%) and 59.9 plus or minus 2.3 mug/liter (CV equals 3.8%). The validity of the assay was further verified by evaluating the plasma 11-deoxycortisol response to metyrapone administration. The relative simplicity of the method and the commercial availability of all reagents, including antisera, makes this radioimmunoassay procedure practical for use in clinical laboratories.  (+info)

CYP11A1 stimulates the hydroxylase activity of CYP11B1 in mitochondria of recombinant yeast in vivo and in vitro. (7/79)

In mammals, hydrocortisone synthesis from cholesterol is catalyzed by a set of five specialized enzymes, four of them belonging to the superfamily of cytochrome P-450 monooxygenases. A recombinant yeast expression system was recently developed for the CYP11B1 (P45011beta) enzyme, which performs the 11beta hydroxylation of steroids such as 11-deoxycortisol into hydrocortisone, one of the three mitochondrial cytochrome P-450 proteins involved in steroidogenesis in mammals. This heterologous system was used to test the potential interaction between CYP11B1 and CYP11A1 (P450scc), the mitochondrial cytochrome P-450 enzyme responsible for the side chain cleaving of cholesterol. Recombinant CYP11B1 and CYP11A1 were targeted to Saccharomyces cerevisiae mitochondria using the yeast cytochrome oxidase subunit 6 mitochondrial presequence fused to the mature form of the two proteins. In yeast, the presence of CYP11A1 appears to improve 11beta hydroxylase activity of CYP11B1 in vivo and in vitro. Fractionation experiments indicate the presence of the two proteins in the same membrane fractions, i.e. inner membrane and contact sites of mitochondria. Thus, yeast mitochondria provide interesting insights to study some molecular and cellular aspects of mammalian steroid synthesis. In particular, recombinant yeast should permit a better understanding of the mechanism permitting the synthesis of steroids (sex steroids, mineralocorticoids and glucocorticoids) with a minimal set of enzymes at physiological level, thus avoiding disease states.  (+info)

Parallel radioimmunoassay for plasma cortisol and 11-deoxycortisol. (8/79)

We describe a direct, rapid, and specific procedure for the parallel radioimmunoassay for cortisol and 11-deoxycortisol in plasma. The plasma sample is used directly, after heat inactivation of the natural cortisol-binding protein. The radioimmunoassay utilizes antibodies generated in rabbits by steroids congugated at their 3-oxo position to thyroglobulin. Ammonium sulfate is used to separate bound and free steroids. Our cortisol antibody and an 11-deoxycortisol antibody obtained elsewhere cross reacted negligibly with each other or with other steroids that might be present in plasma. Radioimmunoassays were therefore developed for both steroids in only 1.25 mul of plasma. The intra- and inter-assay coefficients of variation for both steroids were less than 10%, with a sensitivyt of 4 mug/liter. Steroid values obtained by a competitive protein binding method were consistently higher than those of the present method, suggesting that the former is measuring total corticosteroids. This simple approach requires only 4 h for the specific measurement of both cortisol and 11-deoxycortisol in 20 samples of plasma.  (+info)

*Deoxycortisol

... may refer to: 11-Deoxycortisol (cortodoxone, cortexolone, Reichstein's Substance; 17α,21-dihydroxyprogesterone) ...

*Cortifen

It is a hydrophobic chlorphenacyl nitrogen mustard ester of 11-deoxycortisol (cortodoxone). List of hormonal alkylating ...

*List of corticosteroids

... cortodoxone, cortexolone) = 17α,21-dihydroxypregn-4-ene-3,20-dione 11-Ketoprogesterone (11-oxoprogesterone; Ketogestin) = pregn ...

*List of corticosteroid esters

... cortodoxone chlorphenacyl ester) Cortisone acetate Corticosterone acetate Corticosterone benzoate Cortodoxone acetate ...

*List of drugs: Cm-Co

Cortoderm cortodoxone (INN) Cortone Cortril Cortrophin-Zinc Cortrosyn Corvert Coryphen Codeine Corzide cositecan (USAN, INN) ...

*List of MeSH codes (D06)

... cortodoxone MeSH D06.472.040.585.478.392 --- hydrocortisone MeSH D06.472.040.585.478.782 --- tetrahydrocortisol MeSH D06.472. ...

*11-Deoxycortisol

... , also known as cortodoxone (INN) or cortexolone, as well as 17α,21-dihydroxyprogesterone or 17α,21- ...

*List of MeSH codes (D04)

... cortodoxone MeSH D04.808.745.745.654.339 --- desoxycorticosterone MeSH D04.808.745.745.654.339.400 --- 18- ...
11-Deoxycortisol (Compound S) is the immediate precursor of cortisol:. 11 beta-hydroxylase. 11-deoxycortisol---------------------------,cortisol. Compound S is typically increased when adrenocorticotropic hormone (ACTH) levels are increased (eg, Cushing disease, ACTH-producing tumors) or in 11 beta-hydroxylase deficiency, a rare subform of congenital adrenal hyperplasia (CAH). In CAH due to 11 beta-hydroxylase deficiency, cortisol levels are low, resulting in increased pituitary ACTH production and increased serum and urine 11-deoxycortisol levels.. Pharmacological blockade of 11 beta-hydroxylase with metyrapone can be used to assess the function of the hypothalamic-pituitary-adrenal axis (HPA). In this procedure metyrapone is administered to patients, and serum 11-deoxycortisol levels or urinary 17-hydroxy steroid levels are measured either at baseline (midnight) and 8 hours later (overnight test), or at baseline and once per day during a 2-day metyrapone test (4-times a day metyrapone ...
The adrenal glands, ovaries, testes, and placenta produce steroid hormones, which can be subdivided into 3 major groups: mineral corticoids, glucocorticoids, and sex steroids. Synthesis proceeds from cholesterol along 3 parallel pathways, corresponding to these 3 major groups of steroids, through successive side-chain cleavage and hydroxylation reactions. At various levels of each pathway, intermediate products can move into the respective adjacent pathways via additional, enzymatically catalyzed reactions (see Steroid Pathways in Special Instructions).. 21-Deoxycortisol is an intermediate steroid in the glucocorticoid pathway. While the main substrate flow in glucocorticoid synthesis proceeds from 17-hydroxyprogesterone via 21-hydroxylation to 11-deoxycortisol and then, ultimately, to cortisol, a small proportion of 17-hydroxyprogesterone is also hydroxylated at carbon number 11 by 11-beta-hydroxylase 1 (CYP11B1), yielding 21-deoxycortisol. This in turn can also serve as a substrate for ...
Male Sprague-Dawley rats (Charles River Laboratories, Wilmington, MA) weighing 200 to 350 mg were used to test the duration of sciatic blockade with each of the preparations described below. The rats were anesthetized briefly (less than 1 min) with 2% to 3% halothane in oxygen using a face mask. Sciatic nerve percutaneous blockade was performed through the posterolateral approach immediately medial and cephalad to the greater trochanter and inferior to the sciatic notch of the pelvis. At least four rats were used in each test. After injection, the halothane anesthetic was discontinued and animals were awakened within 1 min. Sensory blockade was examined using a modified unilateral 56 degrees Celsius hotplate technique developed by Masters and coworkers. [2] A cut-off latency of 12 s was used to prevent development of hyperalgesia or injury. Duration of dense sensory blockade was defined operationally as the time from injection to recovery of hot plate latency to 7 s or less. Each leg was tested ...
Results At birth, VPT infants exhibit a global defect in adrenal steroid synthesis pathways leading to lower levels of aldosterone, cortisol and androstenedione than in term infants. This defect was strongly related to GA. On day 3, steroid precursors (progesterone, 11-deoxycorticosterone (DOC), 17-hydroxyprogesterone(17-OH-P) and 11-deoxycortisol (S)) were higher in VPT and negatively correlated with GA. Despite of precursors accumulation, aldosterone and cortisol were similar in the three groups. At birth and day 3, a low cortisol/11-deoxycortisol ratio was found in preterm infants, suggesting an 11-beta-hydroxylase activity (CYP11B1) deficiency. ...
Looking for online definition of 11-deoxycortisol in the Medical Dictionary? 11-deoxycortisol explanation free. What is 11-deoxycortisol? Meaning of 11-deoxycortisol medical term. What does 11-deoxycortisol mean?
The metyrapone test has been improved by specific measurement of plasma 11-deoxycortisol. This simplified method measures 11-deoxycortisol and cortisol in a sample of 0.1 ml of plasma after a standard dose of metyrapone. In normal patients, after metyrapone ingestion, plasma 11-deoxycortisol rises from a base line of 0.8 ± 0.8 µg/100 ml to 16.8 ± 4.4 µg/100 ml, and plasma cortisol falls from 13.5 ± 5.1 µg/100 ml to 3.3 ± 2.8 µg/100 ml. After metyrapone 11-deoxycortisol is reduced only in adrenocorticotrophin (ACTH) deficiency. Patients with hypopituitarism or chronic corticoid therapy and 9 of 12 acromegalics had subnormal levels. Patients with the "empty sella" syndrome or trophic hormone deficiency other than ACTH had normal levels. In primary hypothyroidism postmetyrapone 11-deoxycortisol is significantly greater than in normals. This difference is thought to be caused by delayed metabolic clearance of the steroid. Simultaneous measurement of serum cortisol affords an internal ...
TY - JOUR. T1 - Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila. AU - Moeller, Morten E.. AU - Danielsen, E. Thomas. AU - Herder, Rachel. AU - OConnor, Michael B.. AU - Rewitz, Kim F.. N1 - This work was supported by the Danish Council for Independent Research,Natural Sciences [grant 11-105446 to K.F.R.] and the National Institutes of Health[grant R01 GM093301 to M.B.O.]. PY - 2013. Y1 - 2013. N2 - Steroid hormones trigger the onset of sexual maturation in animals by initiating genetic response programs that are determined by steroid pulse frequency, amplitude and duration. Although steroid pulses coordinate growth and timing of maturation during development, the mechanisms generating these pulses are not known. Here we show that the ecdysone steroid pulse that drives the juvenile-adult transition in Drosophila is determined by feedback circuits in the prothoracic gland (PG), the major steroid-producing tissue of insect larvae. These ...
The overall goal of this research was to verify the involvement of membrane progestin receptor alpha (mPRα) in mediating progestin-stimulated sperm hypermotility in the Atlantic croaker and southern flounder. Sperm motility in Atlantic croaker and southern flounder were tested with both the endogenous progestin, 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S) or the selective mPRα agonist, 10-ethenyl-19-norprogesterone (Org OD 02-0). In croaker, the Pi3k/Akt/Pde and ErbB2/Mapk intracellular signaling pathways were examined. The role of mPRα in mediating sperm hypermotility and fertility in southern flounder was also studied. The effects of seasonal hypoxia on sperm motility in croaker were investigated in a field study in the northern Gulf of Mexico in the fall of 2010. Finally, the effects of acidified activator solution (simulating ocean acidification) were studied in the laboratory. In vitro, Org OD 02-0 mimicked the stimulatory actions of 20β-S in inducing sperm hypermotility and ...
Hypoxia is an endocrine disruptor, altering estrogen, testosterone, and progestin hormone levels and stunting gonadal growth in Atlantic croaker. Steroids act through specific hormone receptors to alter reproductive functions, and the hormonal response is dependent on the concentrations of these receptors. However, information is currently lacking on the effects of hypoxia on expression and functions of membrane receptors mediating rapid, non-genomic steroid actions such as final oocyte maturation and apoptosis. Atlantic croakers were exposed to normoxia (7.0 mg DO/L) or hypoxia (1.7 mg DO/L) for 6 weeks during their period of gonadal recrudescence (October-December). Relative gene expression was quantified using quantitative real-time PCR (qRT-PCR). mRNA expression of the membrane androgen receptor, ZIP9, was increased in hypoxia-exposed fish compared to normoxia-exposed controls, whereas mRNA expression of the membrane estrogen receptor, GPER, and membrane progestin receptor, mPRα, was ...
Metyrapone (trade name Metopirone) is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushings syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-deoxycortisol levels. Metyrapone can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3000 mg, is administered at midnight usually with a snack. The plasma cortisol and 11-deoxycortisol are measured the next morning between 8:00 and 9:00 am. A plasma cortisol less than 220 nmol/l indicates adequate inhibition of 11β-hydroxylase. In patients with intact Hypothalamo-pituitary-adrenal axis, CRH and ACTH levels rise as a response to the falling cortisol levels. This results in an increase of the steroid precursors in the pathway. Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dl (202 nmol/l) and ACTH rises, then it is ...
1 x CJC 1295 - 2mg (Receptor) 1 x Delta Sleep Inducing Peptide 1mg 1 x Cabergoline 0.5mg x 30ml vial I picked up the 1st one when they emailed me it
High performance liquid chromatography (HPLC) is a chemistry technique used to separate chemical compound(s) of interest from other compounds in a liquid sample. When HPLC is coupled to a detection method, these can be quantified to provide detailed information on the chemical composition of a sample. HPLC is commonly used in quality control and research laboratories in the biotechnology, chemical, agricultural, pharmaceutical, dietary supplement, and cosmetic industries.
iiF, RE"F~~ copy & t, Do Not Remove from the Library lJ. S. Fish and Wildlife Service National Wetlands Research Center Biological k?pOrt 82( 10.98) JUNE 1985 HABITAT SUITABILITY INDEX MODELS: JUVENILE ATLANTIC CROAKER (Revised) Fish and Wildlife Service U.S. Department of the Interior This model is designed to be used by the Division of Ecological Services in conjunction with the Habitat Evaluation Procedures. This is one of the first reports to be published in the new "Biological Report" series. This technical report series, published by the Research and Development branch of the U.S. Fish and Wildlife Service, replaces the "FWS/OBS" series published from 1976 to September 1984. The Biological Report series is designed for the rapid publication of reports with an application orientation, and it continues the focus of the FWS/OBS series on resource management issues and fish and wildlife needs. Biological Report 82(10.98) June 1985 HABITAT SUITABILITY INDEX MODELS: JUVENILE ATLANTIC CROAKER ...
76 BOOK REVIEWS The Chemistry of Organic Silicon Compounds S Patai (general ed) Updates on the Silicon-Heteroatom Bond D A Arrnitage (ed) Wiley, Chichester, 1991 540 pages, $90. ISBN 0 471 92904 2 Most chemists reach first for the appropriately coloured Patai volume when looking for the reactions of a particular system or functional group. The previous publication, The Chemistry of Organic Silicon Compounds, like its predecessors in this series, provide a useful coverage of particular topics, but there was one important omission from the main text; it lacked any detailed account of the reactions of the silicon-nitrogen bond. This omission has now been rectified, in that this recent Update volume includes a chapter on the silicon-nitrogen bond, together with an appendix to the Si-N chapter covering publications over the past few years. The observation by the author that there have been 300 references to silicon-nitrogen chemistry over the past three years in the RSC Specialist Reports on ...
11β-Hydroxyprogesterone (11β-OHP), also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone. It is a potent mineralocorticoid. Increased levels of 11β-OHP occur in 21-hydroxylase deficiency. Along with its epimer 11α-hydroxyprogesterone (11α-OHP), 11β-OHP has been identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). 21-Deoxycortisol (11β,17α-dihydroxyprogesterone) 11-Deoxycorticosterone (21-hydroxyprogesterone) Corticosterone (11β,21-dihydroxyprogesterone) Cortisol (11β,17α,21-trihydroxyprogesterone) 11-Deoxycortisol (17α,21-dihydroxyprogesterone) 9α-Bromo-11-ketoprogesterone "Human Metabolome Database: Showing metabocard for 11b-Hydroxyprogesterone (HMDB04031)". hmdb.ca. Retrieved 2016-12-16. Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of ...
A better testing choice is the Metyrapone test.. Unlike ACTH which requires an injection, the metyrapone drug can be given PO orally. The metyrapone test is superior to the ACTH stimulation test because evaluates both hypothalamic and adrenal function. HCG stimulates testicular production of testosterone without impairing fertility, and is therefore a preferred treatment in the er age group. He was also given a small dosage of natural thyroida half grain tablet daily.. Additional treatment protocols were also given as outlined by Dr. Jim had hypothalamic damage from MDMA drug use which caused his low hormone levels and chronic fatigue. LH and FSH then travel to the testicle to stimulate testosterone LH and sperm production FSH.. Chronic recreational drug use with Ecstasy. For Part Three, Click Here Low Testosterone From Pain Pills by Jeffrey Dach MD Dr John Crisler on HCG for Symptoms of Low Testosterone Low Testosterone Diagnosis and Treatment by Jeffrey Dach MD More articles on Low ...
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A sample of venous blood and a 24 hour urine collection may be collected for this test. Methods used collect a sample for this test vary. Depending on the method used, you may need a sample collected more than once, over multiple days, or at specific times. Ask the healthcare worker to explain the details of this test to you. Venous blood: When a blood sample from a vein is needed, a vein in your arm is usually selected. A tourniquet (large rubber strap) may be secured above the vein. The skin over the vein will be cleaned, and a needle will be inserted. You will be asked to hold very still while your blood is collected. Blood will be collected into one or more tubes, and the tourniquet will be removed. When enough blood has been collected, the healthcare worker will take the needle out. 24 hour urine collection: For a 24-hour urine collection, all of the urine that you pass over a 24-hour time period must be collected. If you are in the hospital, a healthcare worker will collect your urine. You ...
At the end of the MS2 and Raoultella trials, an effluent sample was collected a spiked to serve as a control sample to determine whether anti-microbial agents leach into the effluent water. This is critical in terms of claims of treatment within a specific timeframe. This sample was spiked with a known concentration of MS2 (10e3 PFU/mL) and Raoultella (10e3 CFU/mL). Two samples were collected from this seeded control; one sample was analyzed immediately and the other sample was analyzed after approximately three hours contact time. If no anti-microbial agents are present in the treated water, the results for each organism type at different time points are expected to be similar; if analysis of the second sample indicates a substantially lower concentration, it suggests anti-microbial compounds are present in the effluent water. In this case, the compound(s) would need to be identified and neutralized upon sample collection to generate valid microbiological reduction data as the water leaves the ...
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English - Chinese Bio-chemistry Dictionary. By: Joe Hing Kwok Chu. Back to Biochemistry Dictionary Main page. Adrenocortical Hormone, Page 1 Page 1 (index 11-deoxycortisol~18-hydroxycorticosterone). page 2 (3b-hydroxydehydrogenase~cardiac inhibiting factor). page 3 (circadian rhythms ~ dexamethasone). page 4 (metyrapone test ~ stress reaction). page 5 (tetrahydrocortisol ~ water test). Go to Next page ...
11β-hydroxylase deficiency (11β-OHD), an autosomal recessive inherited disorder, accounts for 5-8% of congenital adrenal hyperplasia. In Greece, no cases of 11β-OHD have been described so far. The patient presented at the age of 13 months with mild virilization of external genitalia and pubic hair development since the age of 3 months. Hormonal profile showed elevated 11-deoxycortisol, adrenal androgens and ACTH levels. ACTH stimulation test was compatible with 11β-OHD. DNA of the proband and her parents was isolated and genotyped for CYP11B1 gene coding cytochrome P450c11. The girl was found to be compound heterozygous for two CYP11B1 novel mutations, p.Ala386Glu (exon 7), inherited from the father and p.Leu471Argin (exon 9) from the mother. Hydrocortisone supplementation therapy was initiated. Four years after presentation she remains normotensive, her growth pattern is normal and the bone age remains advanced despite adequate suppression of adrenal androgens. ...
The present invention relates to a cosmetic process for making up and/or caring for keratin material(s), comprising the application, on contact with a keratin material, of at least one cosmetic composition consisting of at least 50% by weight, relative to its total weight, of compound(s) approved for food use, including at least particles with color and/or optical effects containing at least two materials, said particles being referenced in the Codex alimentarius or consisting exclusively of materials referenced in the Codex alimentarius.
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Expression of genes related totriacylglycerol synthesis and catabolism in the liver of large yellow croaker.Values (means±S.E.M.) in bars that have the same le
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11β-hydroxylase deficiency (11β-OHD), an autosomal recessive inherited disorder, accounts for 5-8% of congenital adrenal hyperplasia. In Greece, no cases of 11β-OHD have been described so far. The patient presented at the age of 13 months with mild virilization of external genitalia and pubic hair development since the age of 3 months. Hormonal profile showed elevated 11-deoxycortisol, adrenal androgens and ACTH levels. ACTH stimulation test was compatible with 11β-OHD. DNA of the proband and her parents was isolated and genotyped for CYP11B1 gene coding cytochrome P450c11. The girl was found to be compound heterozygous for two CYP11B1 novel mutations, p.Ala386Glu (exon 7), inherited from the father and p.Leu471Argin (exon 9) from the mother. Hydrocortisone supplementation therapy was initiated. Four years after presentation she remains normotensive, her growth pattern is normal and the bone age remains advanced despite adequate suppression of adrenal androgens. ...
I am female, 25 and recently had an ACTH stimulation test performed. Cortisol started at 6.3 and after an hour jumped to 28.2. My doctor said this was good but everything I have read indicates that this is bad because it is a symptom of secondary adrenal insufficiency. Is my doctor right or should more tests be performed ...
The striped bass is a delicious fish. It has been in the Saguenay for about 10 years but it is prohibited to fish for the purpose of restoring this endangered and protected population under the Species at Risk Act. Anyone who catches a striped bass in the Saguenay must return it to the water immediately, dead or…
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
Bones found at the bottom of a ravine this week in Croaker have been identified as the remains of Steve Huff, James City police said Friday.Huff lived nearby but disappeared without a trace 18
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BARNARD L. The Biosynthesis of Adrenal C11-Oxy C21 Steroids, Implicated in 21-Hydroxylase Deficiency - Desoxycortisol and Desoxycortisone and Their Downstream Metabolism. MSc, 2017. 105 pp. Studieleier: SWART AC.. BARNARD M. The characterization of 17β-hydroxysteroid dehydrogenase type 2 (17βHSD2) activity towards novel C19 substrates. MSc, 2017. 104 pp. Studieleier: STORBECK K.. BARRY CJ. Modelling the glucocorticoid receptor dimerisation cycle. MSc, 2017. 123 pp. Studieleier: ROHWER JM. Medestudieleier: LOUW A.. BURGER R. Flux balance analysis of Plasmodium falciparum growth and energy metabolism. MSc, 2017. 100 pp. Studieleier: SNOEP JL. Medestudieleier: EICHER JJ.. JOHNSTONE E. Comparative secretome analysis of normal prostate and prostate cancer cell models. MSc, 2017. 134 pp. Studieleier: STORBECK K. Medestudieleier: VLOK NM.. JONKER HI. Evaluation of DNA vaccines against Mycoplasma nasistruthionis sp. nov. str. Ms03 infections in ostriches and the production of IgA heavy chain proteins. ...
This study proposes to provide the reference range of cortisol results when the ACTH stimulation test is done under stressful conditions. This important information is currently not available in the literature. To achieve this, we will perform the ACTH stimulation test in a cohort of patients who are booked for elective surgery. By choosing elective surgery patients, we afford ourselves the opportunity of performing the test once before surgery. The test is then repeated within 12 hours of surgery. The first test will be done on an out-patient basis under usual conditions (minimal stress) while the second will be done under intense physical stress. The 2 sets of results will be compared and the effect of stress on test results will be determined. For the sake of uniformity, we have chosen patients who are booked to undergo repair of an abdominal aortic aneurysm (AAA) as our study cohort.. The ACTH stimulation is an important test that suffers from limitations resulting from lack of clear ...
0017] By "corticosteroid" is meant any naturally occurring or synthetic steroid hormone which can be derived from cholesterol and is characterized by a hydrogenated cyclopentanoperhydrophenanthrene ring system. Naturally occurring corticosteroids are generally produced by the adrenal cortex. Synthetic corticosteroids may be halogenated. Functional groups required for activity include a double bond at Δ4, a C3 ketone, and a C20 ketone. Corticosteroids may have glucocorticoid and/or mineralocorticoid activity. In preferred embodiments, the corticosteroid is either fludrocortisone or prednisolone. Exemplary corticosteroids are 11-alpha,17-alpha,21-trihydroxypregn-4-ene-3,20-dione; 11-beta,16-alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione; 11-beta,16-alpha,17,21-tetrahydroxypregn-1,4-diene-3,20-dione; 11-beta,17-alpha,21-trihydroxy-6-alpha-methylpregn-4-ene-3,20-dione; 11-dehydrocorticosterone; 11-deoxycortisol; 11-hydroxy-1,4-androstadiene-3,17-dione; 11-ketotestosterone; ...
60 to 90 minutes after falling asleep. Deep sleep is also called slow wave sleep or delta sleep. Delta sleep precedes REM. Delta sleep is only about 10 percent of ...
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Describes how the 17-hydroxyprogesterone (17-OHP) test is used, when a 17-OHP test is ordered, and what the results of a 17-hydroxyprogesterone test might mean
Long Neck & Cassava Croaker fish exporters in Banjul. Here are their contact addresses, telephone numbers, emails, some faxes, main locations in Gambia.
Recombinant Yeast Thioredoxin produced inE.Coliis a single, non-glycosylated, polypeptide chain. The protein has a molecular mass of 12.6 kDa.
Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines ...
Ethyln-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl)oxy]-3-hydroxy-2-methyloxan-4-yl]carbamate/ACM144285596 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone. Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. This medication will not stop premature labor that has already begun. Hydroxyprogesterone is not for...
ABSTRACT: The aim of this study was to evaluate the effect of environmentally realistic egg loadings of the polychlorinated biphenyl Aroclor 1254 on the subsequent growth and behavioural survival skills of Atlantic croaker Micropogonias undulatus larvae. Adult fish were given a dietary administration of 0 (control) or 0.4 (dosed) mg Aroclor 1254 kg-1 fish d-1 for 2 wk during the final stages of gonadal recrudescence. Fertilised eggs collected from control and dosed adults immediately after spawning contained 0 and 0.66 µg Aroclor 1254 g-1 egg, respectively. Growth rate (increase in total length) of dosed larvae was significantly lower than that of control larvae between 2 and 13 d post-hatching, with dosed larvae showing a 4 d delay in attaining the same size as control larvae. Behavioural assays were conducted to evaluate survival skills of larvae on Days 5 (complete yolk absorption), 9 (complete oil globule absorption), and 13 (larva wholly dependent on exogenous food sources) post-hatching. ...
The 17-hydroxyprogesterone test is mainly used to check for the most common form of the genetic disorder congenital adrenal hyperplasia (CAH) in infants and children.
The thing is, the results of these tests will only go so far. They cant tell you if your levels are high or adrenal-hyperplasia-high. The endo called this a "grey zone," where adrenal hyperplasia still cant be confirmed or ruled out, and further testing is required. And so I am waiting for a nurse from the lab at the hospital to schedule me ACTH stimulation test. I am not going to look this up right now, I think Id rather not know too much about it and risk making myself more nervous, but the endo did explain in a nutshell what happens. I go in, the nurse injects me with something that will stimulate the production of hormones, then do a blood test 30 and 60 minutes afterward. I think Ill be able to handle that, but still, it being at the hospital and something Ive never done before, I know Ill get more and more anxious closer to. So Id appreciate it if readers didnt share their horror stories about this test or anything. Ignorance is bliss right now ...
The reference range of urinary 17-hydroxyprogesterone (17-OHPG) in children is as follows: Age 3 days to 1 year: Up to 50 ng/24 hours Age 1-8 years: Up to 300 ng/24 hours The following is the reference of urinary 17-OHPG in adults: Males: Up to 2 µg/24 hours Females: Up to 4.5 µg/24 hours .
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In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor.. If you miss a dose of danazol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.. DOSAGE. The dose of danazol will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of danazol. If your dose is different, do not change it unless your doctor tells you to do so ...
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Welcome to 4hbtalk.com - The largest 4 Hour Body forum. This forum is a place where you can ask questions about exercises, the slow carb diet, the PAGG stack or anything related to creating your four hour body. The forum was built around The 4-Hour body book by Tim Ferris. This community is in no way affiliated with the 4 Hour Body or Tim Ferris.
Synonyms: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency, Adrenal hyperplasia IV, Adrenal hyperplasia 4, Steroid 11-beta-hydroxylase deficiency, Adrenal hyperplasia hypertensive form, P450c11b1 deficiency, CAH due to 11-beta-hydroxylase deficiency, CYP11B1 deficiency ...
A method for the analysis of testosterone, androstenedione, 5β-dihydrotestosterone, 11-ketotestosterone, estrone, 17β-estradiol, 17α-hydroxyprogesterone, 17α,20β-dihydroxy-4-pregnen-3-one, 5β-pregnane-3α,17α,20α-triol, 5β-androstane-3α,17β-diol, 5β-androstane-3β,17β-diol, 5β-pregnane-3α,17α,20β-triol, 5β-androstane-3α,11β-diol-17-one, 5β-pregnane-3α,17α-diol-20-one, 17α,20β,21-trihydroxy-pregn-4-en-3-one and 11-deoxycortisol in water was developed using gas chromatography-mass spectrometry with selected ion monitoring.. Fish sex steroids were extracted from holding water using C18 SPE cartridges, and eluted using methanol. Free and glucuronide conjugate levels of steroids were determined, glucuronide conjugates by hydrolysis using β-glucuronidase prior to. derivatisation and free steroids by direct derivatisation. The method thus developed was applied to twelve goldfish holding water samples.. Androstenedione was found to be excreted in considerably higher quantities ...
This thread is over a year old but I thought I would check in on you. How are you now? Here is something that may help with what your dealing with. Im 43 years old and a female in 1993 I was diagnosed with Congenital Adrenal Hyperplasia 21 OH deficiency I had a stress dose of cortisol for adrenal crisis and was sent home with no other instructions. Being a young mother and ignorant of this condition I thought it was a one time event and tried to move on with my life. Needless to say for twenty some odd years I had no idea I was in trouble. I had an ACTH stimulation test that showed a morning cortisol of 16 the 17 hydroxyprogesterone level was 10,900 at thirty minutes. I asked for an adrenal washout CT scan and it showed a .09 x 1.3 cm growth on my left adrenal gland. These can produce excess cortisol but is you are CAH 21 OH deficient you cant use it and full physiologic replacement should be given. I recommend Dr Maria New at Mount Sanai hospital in New York she is an expert in ...
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by this medicine.. If you plan to have surgery, including dental surgery, do not take aspirin (contained in this combination medicine) for 5 days before the surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.. If you think you or someone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or other CNS depressants with it may lead to unconsciousness and possibly death. Some signs of an overdose are continuing ringing or buzzing in ears; any hearing loss; severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; staggering; and slow heartbeat.. This medicine may cause some people to become dizzy, ...
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Defective conversion of 17-hydroxyprogesterone to 11-deoxycortisol accounts for more than 90 percent of cases of congenital adrenal hyperplasia (CAH). This conversion is mediated by 21-hydroxylase, the enzyme encoded by theCYP21A2gene.Patients with c
The day when sufficient follicle maturation is observed you will be informed of the exact time for your last injection which will induce final oocyte maturation and ovulation (Pregnyl or Profasi or Ovitrelle) as well as the dose that must be used. This injection is human chorionic gonadotrophin which mimics the LH action and induces final oocyte maturation and ovulation. The injection is administered late in the evening or after midnight. Ovulation is expected about 36 hours later.. This last injection concludes the painful phase of daily injections and marks the end of GnRH analogue and gonadotrophin administration. The following day is a day to rest and prepare for the egg collection. This last injection is very particular in that it must be done at a very specific time, which will be the deciding factor for the time of egg collection. If we attempt to retrieve the eggs before they develop completely, i.e. much earlier than 36 hours after the injection, we shall collect immature eggs. On the ...
Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone [MD:M00107]. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid [MD:M00108]. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate [MD:M00109]. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via ...
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Formula: C14H24N2O7MW: 332. 35Salt: 2HClCAS: 22189-32-8TNP NUMBER: TNP00199MDL NUMBER: MFCD00058104IUPAC: (8S,11S,13S,14S,3R,6R,10R,12R)-12,14-bis(methylamino)-3,11,13-trihydroxy-6-met hyl-2,7,9-trioxatricyclo[8....
290924807 - EP 1124893 B1 2004-12-22 - POLYISOCYANATE POLYADDITION PRODUCTS - [origin: DE19928676A1] Polyisocyanate poly-addition products contains: (i) hydrophobic compounds; (ii) cyclic organic compounds; (iii) certain metal salts; (iv) acid anhydrides; (v) cyclic sulfonic acid esters or sulfones; (vi) lactones, lactams or cyclic esters; and/or (vii) alpha , beta -unsaturated carboxylic acids, acid derivatives, ketones and/or aldehydes. Polyisocyanate poly-addition products (I) containing hydrophobic compounds and other compound(s) selected from: (i) cyclic organic compounds with mol. wts. of 200-3000; (ii) salts of Sub-Group I, II and/or VIII metals; (iii) organic and/or inorganic acid anhydrides; (iv) cyclic sulfonic acid esters or sulfones; (v) lactones, lactams or cyclic esters; and/or (vi) alpha , beta -unsaturated carboxylic acids and their derivatives and alpha , beta -unsaturated ketones and/or aldehydes. Independent claims are also included for: (a) a process for the production of (I)
Get the convenience of timely results and the ability to initiate or modify therapy immediately by measuring cortisol concentrations in your patients using your in-house laboratory.. Each SNAP Cortisol Test lot is tested with canine serum from healthy animals and from animals being tested for adrenal disease using either dexamethasone suppression or ACTH stimulation tests.. This IDEXX internal calibration process ensures that each SNAP Cortisol Test lot maintains a high level of performance and will provide accurate results for patient samples across all areas of the range.. Get a more accurate read on your SNAP tests with the SNAPshot Dx Analyser:. ...
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11-Deoxycortisol - Wikipedia11-Deoxycortisol - Wikipedia

11-Deoxycortisol, also known as cortodoxone (INN) or cortexolone, as well as 17α,21-dihydroxyprogesterone or 17α,21- ...
more infohttps://en.wikipedia.org/wiki/11-Deoxycortisol

11-deoxycortisol (CHEBI:28324)11-deoxycortisol (CHEBI:28324)

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Cortodoxone * Deoxycorticosterone * Fludrocortisone * Antagonists: 6β-Hydroxy-7α-thiomethylspironolactone * 7α- ...
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Cortodoxone / metabolism. Cross-Sectional Studies. Female. Humans. Hydroxytestosterones / metabolism. Male. Middle Aged. Organ ... Cortodoxone; Congenital adrenal hyperplasia due to 21 hydroxylase deficiency ...
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WO 2008/148105 A1 - Endometrial Stem Cells And Methods Of Making And Using Same - 
The LensWO 2008/148105 A1 - Endometrial Stem Cells And Methods Of Making And Using Same - The Lens

Cortodoxone; Deflazacort; Desonide; Desoximetasone; Dexamethasone Dipropionate; Diclofenac Potassium; Diclofenac Sodium; ...
more infohttps://www.lens.org/lens/patent/WO_2008_148105_A1/fulltext

Code System ConceptCode System Concept

Cortodoxone Current Synonym true false 196232018 Cortexolone Current Synonym true false 196233011 Compound S Current Synonym ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=22941009

Deoxycortisol - WikipediaDeoxycortisol - Wikipedia

Deoxycortisol may refer to: 11-Deoxycortisol (cortodoxone, cortexolone, Reichsteins Substance; 17α,21-dihydroxyprogesterone) ...
more infohttps://en.wikipedia.org/wiki/Deoxycortisol

Cortifen - WikipediaCortifen - Wikipedia

It is a hydrophobic chlorphenacyl nitrogen mustard ester of 11-deoxycortisol (cortodoxone). List of hormonal alkylating ...
more infohttps://en.wikipedia.org/wiki/Cortifen

Gendoo - Relevant featuresGendoo - Relevant features

Cortodoxone コルトドキソン Corticotropin-Releasing Hormone コルチコトロピン放出ホルモン Plasminogen Activator Inhibitor 1 プラスミノーゲンアクチベーターインヒビター1 ...
more infohttp://gendoo.dbcls.jp/cgi-bin/gendoo.cgi?geneid=3290&taxonomy=human

Methods Using Lipoprotein-Associated Phospholipase A2 in an Acute Care     Setting - Patent applicationMethods Using Lipoprotein-Associated Phospholipase A2 in an Acute Care Setting - Patent application

Cortodoxone; Deflazacort; Desonide; Desoximetasone; Dexamethasone Dipropionate; Diclofenac Potassium; Diclofenac Sodium; ...
more infohttp://www.patentsencyclopedia.com/app/20130236450

Research - Research Output
     - UC DavisResearch - Research Output - UC Davis

Hathout, Y., Brody, E., Clemens, P. R., Cripe, L., DeLisle, R. K., Furlong, P., Gordish-Dressman, H., Hache, L., Henricson, E. K., Hoffman, E. P., Kobayashi, Y. M., Lorts, A., Mah, J. K., McDonald, C. M., Mehler, B., Nelson, S., Nikrad, M., Singer, B., Steele, F., Sterling, D. & 3 othersSweeney, H. L., Williams, S. & Gold, L., Jun 9 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 23, p. 7153-7158 6 p.. Research output: Contribution to journal › Article ...
more infohttps://ucdavis.pure.elsevier.com/en/organisations/research/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

Abnormalities of 21-hydroxylase gene ratio and adrenal steroidogenesis in hyperandrogenic women with an exaggerated 17...Abnormalities of 21-hydroxylase gene ratio and adrenal steroidogenesis in hyperandrogenic women with an exaggerated 17...

TY - JOUR. T1 - Abnormalities of 21-hydroxylase gene ratio and adrenal steroidogenesis in hyperandrogenic women with an exaggerated 17-hydroxyprogesterone response to acute adrenal stimulation. AU - Azziz, Ricardo. AU - Wells, Gretchen. AU - Zacur, Howard A.. AU - Acton, Ronald T.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - One to 2% of hyperandrogenic women demonstrate a 17-hydroxyprogesterone (17-HP) level greater than 36.3 nmol/L (1200 ng/dL) after acute ACTH-(l-24) adrenal stimulation, consistent with 21-hydroxylase (21-OH) deficient lateonset adrenal hyperplasia (LOAH). The following study was undertaken to endocrinologically and genetically define hyperandrogenic patients with an exaggerated 17-HP response to ACTH stimulation, and which do not represent LOAH. Of 265 consecutive patients suffering from hirsutism and/or hyperandrogenic oligomenorrhea, 23 (8.7%) demonstrated a 17-HP level 30 min post stimulation greater than 9.6 nmol/L or 316 ng/dL (the upper 95th percentile in 41 eumenorrheic ...
more infohttps://augusta.pure.elsevier.com/en/publications/abnormalities-of-21-hydroxylase-gene-ratio-and-adrenal-steroidoge

Livestock Metabolome Database: Showing metabocard for Cortexolone (LMDB00005)Livestock Metabolome Database: Showing metabocard for Cortexolone (LMDB00005)

Cortodoxone. HMDB. Reichstein S. HMDB. ReichsteinS compound S. HMDB. ReichsteinS substance S. HMDB. ...
more infohttp://lmdb.ca/metabolites/LMDB00005

Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension<...Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension<...

TY - JOUR. T1 - Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension. AU - Taylor, A. A.. AU - Mitchell, J. R.. AU - Bartter, F. C.. AU - Snodgrass, W. R.. AU - McMurtry, R. J.. AU - Gill, J. R.. AU - Franklin, R. B.. PY - 1978. Y1 - 1978. N2 - An inhibitor of adrenal steroid biosynthesis, aminoglutethimide, was administered to seven patients with low renin essential hypertension, and the antihypertensive action of the drug was compared with its effects on adrenal steroid production. In all patients aldosterone concentrations in plasma and urine were within normal limits before the study. Mean arterial pressure was reduced from a pretreatment value of 117±2 (mean±SE) mm Hg to 108±3 mm Hg after 4 days of aminoglutethimide therapy and further to 99±3 mm Hg when drug administration was stopped (usually 21 days). Body weight was also reduced from 81.6±7.2 kg in the control period to 80.6±7.0 kg after 4 days of drug treatment and ...
more infohttps://researchexperts.utmb.edu/en/publications/effect-of-aminoglutethimide-on-blood-pressure-and-steroid-secreti

THERAPEUTIC REGIMENS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS - Patent applicationTHERAPEUTIC REGIMENS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS - Patent application

... cortodoxone; daturaolone; deflazacort, 21-deoxycortisol, dehydroepiandrosterone; delmadinone; deoxycorticosterone; deprodone; ... cortodoxone; daturaolone; deflazacort, 21-deoxycortisol, dehydroepiandrosterone; delmadinone; deoxycorticosterone; deprodone; ...
more infohttp://www.patentsencyclopedia.com/app/20120309722

DimethisteroneDimethisterone

11-Deoxycortisol (cortodoxone, cortexolone) *Cortifen (cortiphen, kortifen). *Cortodoxone acetate. *11β-Hydroxyprogesterone ...
more infohttps://readtiger.com/wkp/en/Dimethisterone

GlucocorticoidGlucocorticoid

Cortodoxone (cortexolone, 11-deoxycortisol). *Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone) *Desoxycortone ...
more infohttps://readtiger.com/wkp/en/Glucocorticoid

hydrocortisone sodium succinate - meddichydrocortisone sodium succinate - meddic

11-Deoxycortisol (cortodoxone). *16α,18-Dihydroxy-11-deoxycorticosterone. *17-Hydroxyaldosterone. *18-Hydroxy-11- ...
more infohttp://meddic.jp/hydrocortisone_sodium_succinate

Patent US5413996 - Targeted drug delivery via phosphonate derivatives - Google PatentsPatent US5413996 - Targeted drug delivery via phosphonate derivatives - Google Patents

... cortodoxone, fludrocortisone, flurandrenolone acetonide (flurandrenolide) and paramethasone. ... cortodoxone, fludrocortisone, flurandrenolide, paramethasone and the like. ...
more infohttp://www.google.com/patents/US5413996?dq=7751826

US Patent for Pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use Patent (Patent # ...US Patent for Pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use Patent (Patent # ...

methyl prednisolone, prednisolone, triamcinolone, cortodoxone, flurandrenolone acetonide (flurandrenolide), paramethasone ...
more infohttps://patents.justia.com/patent/9023818

Wound and skin care compositions - Kimberly-Clark Worldwide, Inc.Wound and skin care compositions - Kimberly-Clark Worldwide, Inc.

... cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenolone, fludrocortisone, difluorosone diacetate, ...
more infohttp://www.freepatentsonline.com/8524771.html

Patente US5976555 - Topical oil-in-water emulsions containing retinoids - Google PatentesPatente US5976555 - Topical oil-in-water emulsions containing retinoids - Google Patentes

... cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amciafel, amcinafide, ...
more infohttp://www.google.es/patents/US5976555

Patente US7824601 - Process of making a tubular implantable medical device - Google PatentesPatente US7824601 - Process of making a tubular implantable medical device - Google Patentes

... cortodoxone, deflazacort, desonide, desoximetasone, dexamethasone dipropionate, diclofenac potassium, diclofenac sodium, ...
more infohttp://www.google.es/patents/US7824601

Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.comApplication # 2005/0002865. Diagnostic/therapeutic agents - Patents.com

... cortodoxone, cotarnine chloride, cotinine, cotriptyline, coumaphos, coumazoline, coumermycin, coumetarol, creatinolfosfate, ...
more infohttp://www.patents.com/us-20050002865.html