A family of icosahedral, lipid-containing, non-enveloped bacteriophages containing one genus (Corticovirus).
A genus of GRAM-NEGATIVE AEROBIC BACTERIA of marine origin. Many species were formerly classified under ALTEROMONAS.

The complete genome sequence of PM2, the first lipid-containing bacterial virus To Be isolated. (1/17)

Bacteriophage PM2 was isolated from the Pacific Ocean off the coast of Chile in the late 1960s. It was a new virus type, later classified as Corticoviridae, and also the first bacterial virus for which it was demonstrated that lipids are part of the virion structure. Here we report the determination and analysis of the 10, 079-bp circular dsDNA genome sequence. Noteworthy discoveries are the replication initiation system, which is related to the rolling circle mechanism described for phages such as φX174 and P2, and a 1.2-kb sequence that is similar to the maintenance region of a plasmid found in a marine Pseudoalteromonas sp. strain A28.  (+info)

Purification and protein composition of PM2, the first lipid-containing bacterial virus to be isolated. (2/17)

The marine, icosahedral bacteriophage PM2 was isolated in the late 1960s. It was the first phage for which lipids were firmly demonstrated to be part of the virion structure and it has been classified as the type organism of the Corticoviridae family. The host, Pseudoalteromonas espejiana BAL-31, belongs to a common group of marine bacteria. We developed a purification method producing virions with specific infectivity approximately as high as that of the lipid-containing phages PRD1 and φ6. The sensitivity of the virus to normally used purification media such as those containing sucrose is demonstrated. We also present an alternative host, a pseudoalteromonad, that allows enhanced purification of the virus under reduced salt conditions. We show, using N-terminal amino acid sequencing and comparison with the genomic sequence, that there are at least eight structural proteins in the infectious virus.  (+info)

A conserved genetic module that encodes the major virion components in both the coliphage T4 and the marine cyanophage S-PM2. (3/17)

Sequence analysis of a 10-kb region of the genome of the marine cyanomyovirus S-PM2 reveals a homology to coliphage T4 that extends as a contiguous block from gene (g)18 to g23. The order of the S-PM2 genes in this region is similar to that of T4, but there are insertions and deletions of small ORFs of unknown function. In T4, g18 codes for the tail sheath, g19, the tail tube, g20, the head portal protein, g21, the prohead core protein, g22, a scaffolding protein, and g23, the major capsid protein. Thus, the entire module that determines the structural components of the phage head and contractile tail is conserved between T4 and this cyanophage. The significant differences in the morphology of these phages must reflect the considerable divergence of the amino acid sequence of their homologous virion proteins, which uniformly exceeds 50%. We suggest that their enormous diversity in the sea could be a result of genetic shuffling between disparate phages mediated by such commonly shared modules. These conserved sequences could facilitate genetic exchange by providing partially homologous substrates for recombination between otherwise divergent phage genomes. Such a mechanism would thus expand the pool of phage genes accessible by recombination to all those phages that share common modules.  (+info)

Bacteriophage PM2 has a protein capsid surrounding a spherical proteinaceous lipid core. (4/17)

The marine double-stranded DNA (dsDNA) bacteriophage PM2, studied since 1968, is the type organism of the family Corticoviridae, infecting two gram-negative Pseudoalteromonas species. The virion contains a membrane underneath an icosahedral protein capsid composed of two structural proteins. The purified major capsid protein, P2, appears as a trimer, and the receptor binding protein, P1, appears as a monomer. The C-terminal part of P1 is distal and is responsible for receptor binding activity. The rest of the structural proteins are associated with the internal phospholipid membrane enclosing the viral genome. This internal particle is designated the lipid core. The overall structural organization of phage PM2 resembles that of dsDNA bacteriophage PRD1, the type organism of the family TECTIVIRIDAE:  (+info)

Transcription of bacteriophage PM2 involves phage-encoded regulators of heterologous origin. (5/17)

Bacteriophage PM2 is the only described member of the Corticoviridae family. It is an icosahedral dsDNA virus with a membrane residing underneath the protein coat. PM2 infects some gram-negative Pseudoalteromonas spp. In the present study, we mapped the viral promoters and showed that the PM2 genome consists of three operons. Four new virus genes were assigned based on their function in transcription. Proteins P15 and P16 are shown to repress early transcription, and proteins P13 and P14 are shown to activate late transcription events. The early regulatory region, containing genes for proteins P15 and P16, as well as the newly identified early promoter region in PM2, has significant sequence similarity with the Pseudoalteromonas pAS28 plasmid. P14, the transcription activator for the structural genes, has a zinc finger motif homologous to archaeal and eukaryotic TFIIS-type regulatory factors.  (+info)

Penetration of membrane-containing double-stranded-DNA bacteriophage PM2 into Pseudoalteromonas hosts. (6/17)

The icosahedral bacteriophage PM2 has a circular double-stranded DNA (dsDNA) genome and an internal lipid membrane. It is the only representative of the Corticoviridae family. How the circular supercoiled genome residing inside the viral membrane is translocated into the gram-negative marine Pseudoalteromonas host has been an intriguing question. Here we demonstrate that after binding of the virus to an abundant cell surface receptor, the protein coat is most probably dissociated. During the infection process, the host cell outer membrane becomes transiently permeable to lipophilic gramicidin D molecules proposing fusion with the viral membrane. One of the components of the internal viral lipid core particle is the integral membrane protein P7, with muralytic activity that apparently aids the process of peptidoglycan penetration. Entry of the virion also causes a limited depolarization of the cytoplasmic membrane. These phenomena differ considerably from those observed in the entry process of bacteriophage PRD1, a dsDNA virus, which uses its internal membrane to make a cell envelope-penetrating tubular structure.  (+info)

Biochemical quantitation of PM2 phage DNA as a substrate for endonuclease assay. (7/17)

Bacteriophage PM2 has a closed circular form of double stranded DNA as a genome. This DNA from the phage is a useful source for nick-circle endonuclease assay in the fmol range. Due to difficulties in the maintenance of viral infectivity, storage conditions of the phage should be considered for the purification of PM2 DNA. The proper condition for a short-term storage of less than 2 months is to keep the PM2 phage at 4 degrees C; whereas the proper condition for a long-term storage of the PM2 phage for over 2 months is to keep it under liquid nitrogen in 7.5% glycerol. The optimal conditions for a high yield of phage progeny were also considered with the goal to achieve a successful PM2 DNA preparation. A MOI(Multiplicity Of Infection) of 0.03, in which the OD600 of the host bacteria was between 0.3 and 0.5, turned out to be optimal for the mass production of PM2 phage with a burst size of about 214. Considerations of PM2 genome size, and the concentrations and radiospecific activities of purified PM2 DNA, are required to measure the endonuclease activity in the fmol range. This study reports the proper quantitation of radioactivity and the yield of purified DNA based on these conditions.  (+info)

Preliminary crystallographic analysis of the major capsid protein P2 of the lipid-containing bacteriophage PM2. (8/17)

PM2 (Corticoviridae) is a dsDNA bacteriophage which contains a lipid membrane beneath its icosahedral capsid. In this respect it resembles bacteriophage PRD1 (Tectiviridae), although it is not known whether the similarity extends to the detailed molecular architecture of the virus, for instance the fold of the major coat protein P2. Structural analysis of PM2 has been initiated and virus-derived P2 has been crystallized by sitting-nanodrop vapour diffusion. Crystals of P2 have been obtained in space group P2(1)2(1)2, with two trimers in the asymmetric unit and unit-cell parameters a = 171.1, b = 78.7, c = 130.1 A. The crystals diffract to 4 A resolution at the ESRF BM14 beamline (Grenoble, France) and the orientation of the non-crystallographic threefold axes, the spatial relationship between the two trimers and the packing of the trimers within the unit cell have been determined. The trimers form tightly packed layers consistent with the crystal morphology, possibly recapitulating aspects of the arrangement of subunits in the virus.  (+info)

To infect and replicate, Pseudoalteromonas virus PM2 delivers its genome across the cell envelope of two known marine host strains: gram-negative Pseudoalteromonas species ER72M2 and BAL-31. Virions adsorb via the distal tips of the spike proteins to uncharacterized receptors (Abrescia et al., 2008). The internal membrane mediates the translocation of the supercoiled genome across the host cell envelopes, most probably via fusion in a process that is not fully understood. Replication of the viral genome, most probably by a rolling circle mechanism, takes place in proximity to the host cytoplasmic membrane. The largest Pseudoalteromonas virus PM2 gene XII encoding protein P12 shares significant sequence similarity with the superfamily I group of replication initiation proteins (Männistö et al., 1999). The genome is organized in three operons (Figure 2.Corticoviridae). Operons OEL and OER encode early gene products: the replication initiation protein P12 and transcription regulatory proteins ...
To infect and replicate, PM2 delivers its genome across the cell envelope of two known marine host strains: Gram-negative Pseudoalteromonas species ER72M2 and BAL-31. Virions adsorb via the distal tips of the spike proteins to uncharacterized receptors (Abrescia et al., 2008). The internal membrane mediates the translocation of the supercoiled genome across the host cell envelopes most probably via fusion in a process which is not fully understood. Replication of the PM2 genome, most probably by a rolling circle mechanism, takes place in proximity to the host cytoplasmic membrane. The largest PM2 gene XII encoding protein P12 shares significant sequence similarity with the superfamily I group of replication initiation proteins (Männistö et al., 1999). The genome is organized in three operons (Figure 2.Corticoviridae). Operons OEL and OER encode early function gene products: the replication initiation protein P12 and transcription regulatory proteins P13, P14, P15 and P16. Expression of the ...
A total of 415 patients in whom Buruli ulcer has been clinically diagnosed will be included in the study, which will consist of 332 cases of category I and II Buruli ulcers (,10 cm) confirmed by polymerase chain reaction (PCR), plus 83 non PCR-confirmed Buruli ulcers. Patients will be randomized to receive treatment with the two antibiotic regimens as follows:. (i) Regimen I (SR8): 15 mg/kg streptomycin per day intramuscular injection for 8 weeks plus 10 mg/kg per day oral rifampicin for 8 weeks; (ii) Regimen II (CR8): 15 mg/kg per day oral extended-release clarithromycin for 8 weeks plus 10 mg/kg per day oral rifampicin for 8 weeks.. Assessments before, during and after the course of antibiotic treatment will include full medical history, clinical assessments and monitoring of vital signs, assessment of the lesion, laboratory investigations, hearing test, electrocardiogram, pregnancy test, voluntary HIV counseling and testing, and functional limitation assessment. The primary efficacy ...
Viruses are highly host specific.[5] Studies have shown that marine viruses are more likely to infect cooccurring organisms, those that live in the same region a virus exists in.[6] Therefore, biogeography is an important factor in a virions ability to infect. The knowledge of variation of viral populations across spatiotemporal and other environmental gradients is supported viral morphology, determined by transmission electron microscopy (TEM). Non-tailed viruses appear to be dominant in multiple depths and oceanic regions, followed by the Caudovirales myoviruses, podoviruses, and siphoviruses.[7] However, viruses belonging to families Corticoviridae,[8] Inoviridae[9] and Microviridae[10] are also known to infect diverse marine bacteria. Metagenomic evidence suggests that microviruses (icosahedral ssDNA phages) are particularly prevalent in marine habitats.[10] Metagenomic approaches to assess viral diversity are often limited by a lack of reference sequences, leaving many sequences ...
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced gly
TY - JOUR. T1 - Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA. AU - Lloyd, R. Stephen. AU - Haidle, Charles W.. AU - Hewitt, Roger R.. PY - 1978/10. Y1 - 1978/10. N2 - Bleomycin-induced breakage of an isolated covalently closed circular DNA from bacteriophage PM2 was assayed fluorometrically after agarose gel electrophoresis and staining with ethidium bromide. When bleomycin-damaged DNA was assayed under neutral conditions, there was a decrease in the amount of Form I DNA and a simultaneous increase in both Forms II and III of DNA. However, when the damage was assayed under nondenaturing alkaline conditions, there was a greater decrease in the amount of Form I DNA and a corresponding increase in both Forms II and III DNA compared with neutral conditions. Approximately one alkaline-labile site was formed for every single-strand break introduced. The rate of formation of Form III DNA was found to be approximately twice as fast when measured under alkaline ...
SARS Vaccine Compositions and Methods of Making and Using Them - Described is a composition and method for reducing the occurrence and severity of infectious diseases, especially infectious diseases such as SARS, in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating immunogenic modified, partially delipidated viral particles with reduced infectivity. The present invention provides delipidated viral vaccine compositions, such as therapeutic vaccine compositions, comprising these modified, partially delipidated viral particles with reduced infectivity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism or, in case of a therapeutic vaccine, to treat or ...
Titering of Bacterial Viruses Related protocols: Preparation of Phage Stocks Commonly Used Media for Phage Growth Agar Overlay Technique When an individual bacterial virus grows in a bacterial host suspended in a top agar lawn, its progeny infect and lyse the surrounding host cells. This causes the appearance of a hole or plaque in…
Culture supernatant of Staphylococcus aureus, isolated from a patient who died after surgery induced granulation in several cultured cell lines of human and animal origin.
TAKEUCHI Osamu , KAWAI Taro , MUHLRADT Peter F. , MORR Michael , RADOLF Justin D. , ZYCHLINSKY Arturo , TAKEDA Kiyoshi , AKIRA Shizuo International immunology 13(7), 933-940, 2001-07-01 DOI 参考文献30件 被引用文献37件 ...
This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.
Mycobacteria are distinguished from other micro-organisms by thick lipid-containing cell-walls that retain biochemical stains despite decolourisation by acid-containing reagents (so-called acid-fastness). Advantages: Microscopy of sputum smears is simple and inexpensive, quickly detecting infectious cases of pulmonary […]. ...
WASHINGTON, D.C. - The U.S. Agency for International Development (USAID) will host a forum on how sport is being used as an innovative and effective tool in international development and public engagement. The event will bring together high-profile speakers including Two Time All-Pro Wide Receiver with the Green Bay Packers Greg Jennings; former National Football League (NFL) Linebacker and founder of BowTieCause.org Dhani Jones; Phil de Picciotto, Founder & President Octagon, Inc. and USAID Administrator Rajiv Shah. The panel will be moderated by noted American political sportswriter Dave Zirin and will be preceded by remarks from former NFL Commissioner Paul Tagliabue.. ...
Cystovirus is a genus of viruses, in the family Cystoviridae. Pseudomonas syringae pathovar phaseolicola bacteria serve as natural hosts. There is currently only one species in this genus: the type species Pseudomonas phage phi6. Group: dsRNA Order: Unassigned Family: Cystoviridae Genus: Cystovirus Pseudomonas phage phi6 Pseudomonas phage phi8 Pseudomonas phage phi12 Pseudomonas phage phi13 Pseudomonas phage phi2954 Pseudomonas phage phiNN Pseudomonas phage phiYY Cystoviruses are distinguished by their tripartite dsRNA genome, totaling ~14 kb in length and their protein and lipid outer layer. No other bacteriophage has any lipid in its outer coat, though the Tectiviridae and the Corticoviridae have lipids within their capsids. Most identified cystoviruses infect Pseudomonas species, but this is likely biased due to the method of screening and enrichment. The type species is Pseudomonas phage phi6, but there are many other proposed members of this family. Pseudomonas phage φ7, φ8, φ9, φ10, ...
I have analyzed the time course of phage PR4 protein synthesis and have identified at least 34 proteins present in phage infected cells not detected in uninfected control cultures. In addition, I have isolated a more extensive set of conditional-lethal nonsense mutants of this virus. This collection of mutants permitted the identification of seven additional phage PR4 gene products, including the terminal genome protein and an accessory lytic factor. The present collection of phage PR4 mutants has been assigned to 19 distinct genetic groups on the basis of genetic complementation tests and sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis of the proteins produced in mutant infected UV irradiated cells ...
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Only recently have reproducible protocols for analyzing fecal phages emerged. A new review from University College Corks scientists explores the composition and relevance for health of the wide community of bacterial viruses colonizing our gastrointestinal tract.
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This was a fantastic opportunity to investigate the positive applications of bacterial viruses to fight infections. The recent and ongoing antibiotic-resistance crisis has heightened our awareness that we need to find alternative solutions to traditional antibiotic therapies. We isolated and tested the effectiveness of a number of bacterial viruses that can kill E. coli and Shigella, which are associated with gut infections. In the developed world, antibiotics have been used for decades to treat such infections rapidly but in developing countries, the water quality and sanitary conditions may create the perfect conditions for the growth of such illness-causing bacteria and antibiotic therapies may not be readily available. The lack of suitable treatments makes these infections potentially lethal, particularly to infants. Therefore, alternative treatments are required and bacterial viruses, or their encoded proteins, have the potential to be the next generation of antimicrobials to benefit all in ...
A team of Chinese and Danish researchers has identified 500 new species of gut-residing microorganisms and 800 new bacterial viruses which could attack them. The findings could lead to promising new t...
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Corticoviridae. NCBI Taxonomy. Kiveld, H.M., Kalkkinen, N. and Bamford, D.H. (2002). Bacteriophage PM2 has a protein capsid ... "Corticoviridae". ICTV Online (10th) Report. "Viral Zone". ExPASy. Retrieved 15 June 2015. Krupovic M, Bamford DH (2007). " ... Corticovirus is a genus of viruses in the family Corticoviridae. Corticoviruses are bacteriophages; that is, their natural ... ICTV Online(10th) Report: Corticoviridae Viralzone: Corticovirus (Articles with short description, Short description is ...
These non-tailed phages also infect marine bacteria, and include the families Corticoviridae,Inoviridae,Microviridae and ... However, viruses belonging to families Corticoviridae, Inoviridae and Microviridae are also known to infect diverse marine ...
Bacteriophages belonging to the families Corticoviridae, Inoviridae and Microviridae are also known to infect diverse marine ...
Phages belonging to the families Corticoviridae,Inoviridae,Microviridae, and Autolykiviridae are also known to infect diverse ...
... which is related to bacterial virus families Tectiviridae and Corticoviridae and many eukaryotic virus families such as ...
No other bacteriophage has any lipid in its outer coat, though the Tectiviridae and the Corticoviridae have lipids within their ...
... in the case of the family Corticoviridae. An exception is the order Halopanivirales, whose members do not encode any ...
Caulimoviridae Chaseviridae Chrysoviridae Chuviridae Circoviridae Clavaviridae Closteroviridae Coronaviridae Corticoviridae ...
... family Corticoviridae), which has a double-stranded DNA genome. A similar major capsid protein fold is also found in other ...
Corticoviridae Active Synonym false false 2648448013 Family Corticoviridae Active Synonym false false ...
Corticoviridae - Preferred Concept UI. M0028649. Scope note. A family of icosahedral, lipid-containing, non-enveloped ... Corticoviridae. Scope note:. Familia de bacteriófagos icosaédrocos que contienen lípidos y carecen de envoltura; contiene sólo ... Corticoviridae Entry term(s):. Alteromonas phage PM2. Bacteriophage PM2. Bacteriophage, PM2. Bacteriophages, PM2. Corticovirus ...
Bacteriophage PM2 use Corticoviridae Bacteriophage PRD1 Bacteriophage Q beta use Allolevivirus Bacteriophage T2 use ...
Ascoviridae · Baculoviridae · Corticoviridae · Fuselloviridae · Guttaviridae · Lipothrixviridae · Nimaviridae · Plasmaviridae · ...
... phage of the Corticoviridae family), PR772 (a dsDNA phage of the Tectiviridae family), human influenza A virus H1N1 (an ssRNA ...
Bacteriophage PM2 use Corticoviridae Bacteriophage PRD1 Bacteriophage Q beta use Allolevivirus Bacteriophage T2 use ...
Bacteriophage PM2 use Corticoviridae Bacteriophage PRD1 Bacteriophage Q beta use Allolevivirus Bacteriophage T2 use ...
Bacteriophage PM2 use Corticoviridae Bacteriophage PRD1 Bacteriophage Q beta use Allolevivirus Bacteriophage T2 use ...
Bacteriophage PM2 use Corticoviridae Bacteriophage PRD1 Bacteriophage Q beta use Allolevivirus Bacteriophage T2 use ...
Corticoviridae * Corticovirus * Fuselloviridae * Alphafusellovirus * Betafusellovirus * Globuloviridae * Globulovirus * ...
This graph shows the total number of publications written about "Salmonella Phages" by people in this website by year, and whether "Salmonella Phages" was a major or minor topic of these publications ...
Corticoviridae. VIRION. Icosahedral T=21 capsid 56 nm in diameter, composed of 1200 P1 (spike) and 60 P2 (capsid) proteins. The ...
Corticoviridae B04.123.370 Inoviridae B04.123.370.400 Inovirus B04.123.370.400.240 Bacteriophage IKe B04.123.370.400.250 ...
Corticoviridae Preferred Term Term UI T057308. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1997). ... The sole species in the genus Corticovirus, family CORTICOVIRIDAE.. Terms. Alteromonas phage PM2 Preferred Term Term UI T431054 ... Corticoviridae Preferred Concept UI. M0028649. Registry Number. txid10659. Related Numbers. txid10660. txid10661. Scope Note. A ... Corticoviridae. Tree Number(s). B04.123.210. Unique ID. D019240. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D019240 ...
Corticoviridae Preferred Term Term UI T057308. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1997). ... The sole species in the genus Corticovirus, family CORTICOVIRIDAE.. Terms. Alteromonas phage PM2 Preferred Term Term UI T431054 ... Corticoviridae Preferred Concept UI. M0028649. Registry Number. txid10659. Related Numbers. txid10660. txid10661. Scope Note. A ... Corticoviridae. Tree Number(s). B04.123.210. Unique ID. D019240. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D019240 ...
Family Corticoviridae (organism) {424406001 , SNOMED-CT } Download Relationships Other Relationships No other relationships ...
Corticoviridae. Cystoviridae. Inoviridae. Leviviridae. Lipothrixviridae. Microviridae. Myoviridae. Plasmaviridae. Podoviridae. ...
... subchondral sexta thulium pinkus niclosamide proplast bafilomycin crataegus benzenedithiol lyxofuranosyl corticoviridae ...
Corticoviridae phages- no envelope, 63 nm in size, complex capsid, lipids, dsDNA. *Phage PM2 ...
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Corticoviridae Corticovirus*Corticovirus. *Taxonomy. - 2 complete genomes Retrieve sequences: -- Select data set from the list ...
Corticoviridae [39] Cystoviridae Dicistroviridae [41] Elaviroid Endornaviridae [43] Filoviridae Flaviviridae [45 ...
The nucleotide or predicted amino acid sequences of the subfamily members form a distinct lineage within the family. Certain genes may be unique to members of the subfamily. These include BNRF-1, BTRF-1 and BRLF-1 of HHV-4 (the corresponding ORFs of saimiriine herpesvirus 2 are ORFs 3, 23 and 50, respectively). Many members of the subfamily infect lymphocytes in vitro, and "carrier" cultures can be established in which a minority of cells is productively infected. Latent infection in vivo occurs in lymphocytes or lymphoid tissue. Acute infection is frequently associated with lymphoproliferative disorders and many members of the subfamily are associated with malignancies of lymphoid and non-lymphoid origin.. ...
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Corticoviridae Cortinarius Cortisone Cortisone Reductase Cortodoxone Corydalis Corylus Corynebacterium Corynebacterium ...
Corticosterone Corticotrophs Corticotropin-Like Intermediate Lobe Peptide Corticotropin-Releasing Hormone Corticoviridae ...
  • The virion organization (pseudo T=21 dextro) and major capsid protein fold (double-β-barrel) resemble those of Pseudoalteromonas phage PM2 (family Corticoviridae), which has a double-stranded DNA genome. (jyu.fi)
  • The sole species in the genus Corticovirus, family CORTICOVIRIDAE. (bvsalud.org)
  • The sole species in the genus Corticovirus, family CORTICOVIRIDAE . (nih.gov)