A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS. Its sequence is identical to the C-terminal 22-amino acids of ACTH or ACTH 18-39.
A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
The intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Neuroendocrine cells in the INTERMEDIATE LOBE OF PITUITARY. They produce MELANOCYTE STIMULATING HORMONES and other peptides from the post-translational processing of pro-opiomelanocortin (POMC).
Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.

In-source decay characteristics of peptides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. (1/7)

In-source decay (ISD) of peptides, coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, has been examined to determine the influence of the matrix, the susceptibility of amino-acid residues to ISD, and the effect of extraction delay times. Out of nine di- and tri-hydroxybenzoic acids and three cinnamic derivatives tested, the most suitable matrix for ISD was 2,5-dihydroxybenzoic acid. The amine bond at Xxx-Gly and Xxx-Val residues was less susceptible than other amino-acid residues to ISD; however, the more sensitive residue(s) were not as clear. Using a peptide that gave the y(n)- and (z(n) + 2)-series product ions, it was confirmed that amide-bond cleavage (formation of the y(n)-series ions) accompanied metastable peaks, whereas metastable peaks were never observed with amine-bond cleavage [formation of the (z(n) + 2)-series ions]. Furthermore, abundant c(n)-series ions, which originate from amine-bond cleavage on the peptide backbone, were observed whenever a minimum delay time of 38 ns or continuous extraction was used to obtain spectra. These data indicate that amine-bond cleavage in ISD takes place on the ionization time scale before the energy randomization is completed.  (+info)

Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract. (2/7)

The alpha-melanocyte-stimulating hormone (alpha-MSH), derived from proopiomelanocortin (POMC), is generated by a posttranslational processing mechanism involving the prohormone convertases (PCs) PC1/3 and PC2. In the brain, alpha-MSH is produced in the arcuate nucleus (ARC) of the hypothalamus and in the nucleus of the solitary tract (NTS) of the medulla. This peptide is key in controlling energy balance, as judged by changes observed at transcriptional level. However, little information is available regarding the biosynthesis of the precursor POMC and the production of its processed peptides during feeding, fasting, and fasting plus leptin in the ARC compared with the NTS in conjunction with the PC activity. In this study we found that, in the ARC, pomc mRNA, POMC-derived peptides, and PC1/3 all decreased during fasting, and administration of leptin reversed these effects. In contrast, in the NTS, where there is a large amount of a 28.1-kDa peptide similar in size to POMC, the 28.1-kDa peptide and other POMC-derived peptides, including alpha-MSH, were further accumulated in fasting conditions, whereas pomc mRNA decreased. These changes were not reversed by leptin. We also observed that, during fasting, PC2 levels decreased in the NTS. These data suggest that, in the NTS, fasting induced changes in POMC biosynthesis, and processing is independent of leptin. These observations indicate that changes in energy status affect POMC in the brain in a tissue-specific manner. This represents a novel aspect in the regulation of energy balance and may have implications in the pathophysiology of obesity.  (+info)

Multiple feedback regulatory loops upon rat hypothalamic corticotropin-releasing hormone secretion. Potential clinical implications. (3/7)

To examine whether the hypothalamic corticotropin-releasing hormone (CRH) neuron is regulated by CRH, by products of the proopiomelanocortin (POMC) gene, and/or by glucocorticoids, we used a rat hypothalamic organ culture system in which rat CRH secretion from single explanted hypothalami was evaluated by an RIA (iCRH) specific for rat CRH. The effects of graded concentrations of ovine CRH (oCRH), adrenocorticotropin hormone (ACTH), beta-endorphin (beta-EP), alpha-melanocyte-stimulating hormone (alpha-MSH), corticotropin-like intermediate lobe peptide (CLIP), ovine beta-lipotropin (ovine beta-LPH), and dexamethasone (DEX) upon unstimulated and serotonin- (5HT), acetylcholine- (ACh), and norepinephrine-(NE) stimulated CRH secretion were determined. oCRH and DEX inhibited unstimulated iCRH secretion with ID50 at the 10(-8) M range. ACTH had no detectable suppressive effect at 10(-8) M. oCRH, ACTH, and DEX inhibited 5HT-, ACh-, and NE-stimulated iCRH secretion in a dose-dependent fashion. beta-EP, alpha-MSH, and CLIP also inhibited 5HT-induced iCRH secretion. Of the latter peptides, the strongest inhibitor was beta-EP and the weakest was CLIP. Ovine beta-LPH had only a weak inhibitory effect on 5HT-induced iCRH secretion. Generally, the concentrations required for 50% suppression of neurotransmitter-stimulated iCRH secretion were significantly lower than those required for a similar suppression of unstimulated iCRH secretion. In conclusion, these data suggest the presence of multiple negative feedback loops involved in the regulation of the hypothalamic CRH neuron: an ultrashort CRH-mediated loop, a short, hypothalamic POMC-derived peptide loop, and a long, glucocorticoid-mediated negative feedback loop. The potency of these negative feedback loops may be determined by the state of activation of the CRH neuron.  (+info)

Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. (4/7)

The proteolytic processing pattern of pro-ACTH/endorphin in rat hypothalamus is similar to the pattern in the pars intermedia; peptides the size of beta-endorphin, gamma-lipotropin (gamma-LPH), corticotropin-like intermediate lobe peptide (CLIP), alpha-melanotropin (gamma-MSH), joining peptide, and glycosylated gamma 3-MSH all represent predominant end products. Equimolar amounts of beta-endorphin-, alpha-MSH-, CLIP-, gamma-LPH-, and joining peptide-related immunoreactivity are found in hypothalamic extracts (approximately 3 pmol per hypothalamus). Although the proteolytic processing pattern in the hypothalamus is similar to that in the pars intermedia, a tissue-specific posttranslational processing pattern was detected. Ion-exchange analysis of beta-endorphin-sized immunoreactive material from hypothalamic extracts resolves three major forms, corresponding to beta-endorphin(1-31), beta-endorphin(1-27), and beta-endorphin(1-26). The alpha-N-acetylated forms of endorphin represent less than 10% of the total beta-endorphin immunoreactivity. Analyses of hypothalamic alpha-MSH-sized molecules with acetyl- and amide-directed alpha-MSH antisera suggest that hypothalamic alpha-MSH is fully amidated, but largely not alpha-N-acetylated. Fractionation by reverse-phase high-performance liquid chromatography (HPLC) confirms that greater than 85% of the alpha-MSH immunoreactivity corresponds to ACTH(1-13)NH2 or its sulfoxide, and less than 10% corresponds to alpha-MSH [alpha-N-acetyl-ACTH(1-13)NH2] or its sulfoxide. Isoelectric focusing demonstrates that 83-93% of hypothalamic CLIP is phosphorylated. Isoelectric focusing suggests that the majority of the hypothalamic gamma-LPH-sized immunoreactive material is indistinguishable from gamma-LPH synthesized by pituitary melanotropes. The minor extent of alpha-N-acetylation of alpha-MSH and beta-endorphin, the limited carboxyl-terminal proteolysis of beta-endorphin, and the extensive phosphorylation of CLIP represent major differences between the posttranslational processing patterns of pro-ACTH/endorphin in the hypothalamus and pars intermedia.  (+info)

Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. (5/7)

Naturally occurring derivatives of pro-opiomelanocortin (POMC) have been identified in various extra-pituitary sites, including the endocrine and exocrine pancreas. Corticotropin-like intermediate lobe peptide (CLIP = ACTH18-39), a naturally occurring derivative of POMC, has been suggested to be an insulin secretagogue. To determine whether CLIP might also affect the exocrine pancreas, we measured its effect on amylase secretion and protein synthesis and secretion in isolated rat pancreatic lobules. Lobules were dual-pulsed with trace amounts of 14C- and 3H-leucine, both in the presence and absence of CLIP (10(-9)-10(-6) M), using a technique that permitted the labeling of both the synthetic and secretory compartments. The effect of CLIP on protein synthesis was determined by comparing 3H-leucine incorporation into lobules with and without CLIP. The secretory effect of CLIP was determined by measuring (a) secreted 14C-labeled protein as a percent of total incorporated radiolabeled protein, and (b) amylase release into incubation medium. The effect of CLIP on amylase release was compared with that of secretin, cholecystokinin-octapeptide, and carbamylcholine. To localize the biologically active region of CLIP, we similarly studied synthetic ACTH25-39. We demonstrated that CLIP stimulates amylase and protein secretion in a dose-dependent manner and is of similar potency to secretin and carbamylcholine. This effect appears to require the ACTH18-24 region of CLIP and results from stimulus-secretion coupling rather than augmented protein synthesis. We also confirmed the presence of immunoreactive-adrenocorticotropic hormone (IR-ACTH) in rat pancreatic extract using a COOH-terminally directed antibody to ACTH1-39 and demonstrated that this IR-ACTH co-eluted with synthetic CLIP. These findings suggest that CLIP might be an endogenous modulator of pancreatic exocrine function.  (+info)

Biosynthesis of phosphorylated forms of corticotropin-related peptides. (6/7)

Phosphorylated forms of corticotropin[ACTH (1-39)], corticotropin-like intermediary lobe peptide[CLIP, ACTH (18-39)], and the common precursor for ACTH and beta-lipotropin (beta-LPH) have been identified in extracts of rat pituitaries, 32P-Labeled inorganic phosphate was successfully incorporated into ACTH (1-39), CLIP, and the ACTH/beta-LPH precursor in rat neurointermediary lobe explants and into ACTH (1-39) in isolated rat anterior pituitary cells. After peptidase digestion of the labeled CLIP and ACTH, the radioactive phosphate was recoverable as O-phosphoserine. The serine residue at position 31 was the only amino acid found to be phosphorylated in CLIP and ACTH (1-39). The unphosphorylated forms of both peptides were also synthesized. The demonstration of he incorporation of [32P]phosphate into CLIP, ACTH (1-39), and the ACTH/beta-LPH precursor is consistent with the hypothesis that, within the rat intermediary lobe, phosphorylated CLIP is derived from a phosphorylated form of the common precursor, with phosphorylated ACTH (1-39) acting as a biosynthetic intermediate.  (+info)

Characterization of eight forms of corticotropin-like intermediary lobe peptide from the rat intermediary pituitary. (7/7)

The isolation and characterization of eight forms of corticotropin-like intermediary lobe peptide (CLIP, adrenocorticotropin18-39) from the intermediary lobe of the rat pituitary has been accomplished by using reversed phase high performance liquid chromatography. The eight forms are the result of all combinations of the presence or absence of three post-translational modifications. These are glycosylation, phosphorylation, and removal of the carboxyl-terminal amino acid. The sites of phosphorylation and glycosylation are at serine 31 and asparagine 29, respectively. The eight forms (in order of elution from the reversed high performance liquid chromatography column) are glycosylated, phosphorylated CLIP18-38; glycosylated, nonphosphorylated CLIP18-38; nonglycosylated, phosphorylated CLIP18-38; nonglycosylated, nonphosphorylated CLIP18-38; glycosylated, phosphorylated CLIP18-39; glycosylated, nonphosphorylated CLIP18-39; nonglycosylated, phosphorylated CLIP18-39; and nonglycosylated, nonphosphorylated CLIP18-39.  (+info)

Corticotropin-Like+Intermediate+Lobe+Peptide at the US National Library of Medicine Medical Subject Headings (MeSH) (Genes on ... Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), ... Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". ...
Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... These peptide hormones are stored within vesicles in the corticotropic cells and are released in response to CRH stimulation ... These peptide hormones are then released into the bloodstream, where they circulate and act on target tissues. ACTH released ... CRH is a 41-amino-acid peptide hormone that is secreted by the parvocellular neurosecretory cells, which are found within the ...
... with the intermediate lobe that joins the two regions. In many animals, these three lobes are distinct. The intermediate is ... bombesin-like peptides (gastrin-releasing peptide, neuromedin B and C), and neurotensin, and inhibited by hypothalamic dopamine ... and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing hormone (CRH).: ... This is also produced in the anterior lobe. When produced in the intermediate lobe, MSHs are sometimes called "intermedins". ...
... and capillary shunts exchanging blood between the intermediate and neural lobes. Such microvascular structures indicate moment- ... The peptides released at the median eminence enter the primary plexus capillaries. From there, they are transported to the ... The main hormones transported by the system include gonadotropin-releasing hormone, corticotropin-releasing hormone, growth ... Peptides released near the median eminence from hypothalamic nuclei are transported to the anterior pituitary, where they apply ...
The intermediate lobe of the pituitary gland secretes only one enzyme that is melanocyte stimulating hormone. It is linked with ... Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the ... Adrenocorticotropic hormone release is triggered by corticotropin-releasing hormone and inhibited by rising glucocorticoid ...
Corticotropin (Adrenocorticotropic Hormone, or ACTH) Corticotropin-like Intermediate Peptide (CLIP) β-Lipotropin (β-LPH) Gamma ... The POMC gene is expressed in both the anterior and intermediate lobes of the pituitary gland. This gene encodes a 285-amino ... POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core ... while α-MSH secreted from the intermediate lobe of the pituitary regulates the movement of melanin produced from melanocytes in ...
Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow ... POMC, ACTH and β-lipotropin are secreted from corticotropic cells in the anterior lobe (or adenohypophysis) of the pituitary ... Veldhuis JD, Iranmanesh A, Naftolowitz D, Tatham N, Cassidy F, Carroll BJ (November 2001). "Corticotropin secretory dynamics in ... many substances secreted within this axis exhibit slow/intermediate and fast feedback-loop activity. Glucocorticoids secreted ...
Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number of granules in an eosinophil can vary because ... Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes. Examples of ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... MCs contain numerous granules and secrete an abundance of prestored mediators such as corticotropin-releasing hormone (CRH), ...
The pituitary gland is divided into three lobes: the anterior pituitary, the intermediate pituitary lobe, and the posterior ... The peptides secreted by hypothalamic neuroendocrine neurons into the blood proved to be released also into the brain, and the ... "On the presence in hog hypothalamus of 3-corticotropin releasing factor, alpha- and beta-melanocyte stimulating hormones, ... These two neuronal systems project axons to the median eminence, where they release their peptides into portal blood vessels ...
Corticotropin-Like Intermediate Lobe Peptide. D6.472.699.631.525.475.498 D6.472.699.631.525.600.498. Cosyntropin D6.472.699.631 ... Occipital Lobe A8.186.211.730.885.213.571 A8.186.211.730.885.287.500.571. Oleanolic Acid D2.455.849.919.530.733. Olfactory Bulb ... Parietal Lobe A8.186.211.730.885.213.670 A8.186.211.730.885.287.500.670. Passive Cutaneous Anaphylaxis E5.478.594.800.600. ... Pituitary Gland, Intermediate A6.407.747.671 A6.407.747.750. A6.688.357.750.717 A6.688.357.750.750. A8.186.211.730.385.357. ...
Corticotropin-Like Intermediate Lobe Peptide Preferred Concept UI. M0066247. Registry Number. 53917-42-3. Scope Note. A peptide ... Corticotropin-Like Intermediate Lobe Peptide Preferred Term Term UI T096250. LexicalTag NON. ThesaurusID NLM (2007). ... Corticotropin-Like Intermediate Lobe Peptide. Tree Number(s). D06.472.699.327.935.498. D06.472.699.631.525.600.498. D12.644. ... A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but ...
Influence of a 1 h immobilization stress on sleep states and corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39, ... 2. Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in ... 7. Corticotrophin-related peptides in the intermediate lobe of the rodent pituitary gland: characterization by high performance ... Characterization of eight forms of corticotropin-like intermediary lobe peptide from the rat intermediary pituitary.. Bennett ...
Corticotropin-Like Intermediate Lobe Peptide Entry term(s). ACTH(18-39) CLILP CLIP (ACTH 18-39) Corticotropin Like Intermediate ... Corticotropin-Like Intermediate Lobe Peptide - Preferred Concept UI. M0066247. Scope note. A peptide derived from the cleavage ... Corticotropin-Like Intermediate Lobe Peptide Descriptor Spanish: Péptido de la Porción Intermedia de la Adenohipófisis Similar ... Corticotropin Like Intermediate Lobe Peptide. Tree number(s):. D06.472.699.327.935.498. D06.472.699.631.525.600.498. D12.644. ...
Corticotropin-Like Intermediate Lobe Peptide Preferred Concept UI. M0066247. Registry Number. 53917-42-3. Scope Note. A peptide ... Corticotropin-Like Intermediate Lobe Peptide Preferred Term Term UI T096250. LexicalTag NON. ThesaurusID NLM (2007). ... Corticotropin-Like Intermediate Lobe Peptide. Tree Number(s). D06.472.699.327.935.498. D06.472.699.631.525.600.498. D12.644. ... A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but ...
Corticotropin-Like Intermediate Lobe Peptide. D6.472.699.631.525.475.498 D6.472.699.631.525.600.498. Cosyntropin D6.472.699.631 ... Occipital Lobe A8.186.211.730.885.213.571 A8.186.211.730.885.287.500.571. Oleanolic Acid D2.455.849.919.530.733. Olfactory Bulb ... Parietal Lobe A8.186.211.730.885.213.670 A8.186.211.730.885.287.500.670. Passive Cutaneous Anaphylaxis E5.478.594.800.600. ... Pituitary Gland, Intermediate A6.407.747.671 A6.407.747.750. A6.688.357.750.717 A6.688.357.750.750. A8.186.211.730.385.357. ...
CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).. ... Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).. ... Corticotropin-Releasing Hormone. A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. ... It is hypothesised BMS-654457 that silent corticotroph adenomas (SCA) originate from the intermediate lobe, while adenomas ...
... ovine N0000167495 Corticosterone N0000175137 Corticotropin-Like Intermediate Lobe Peptide N0000007539 Corticotropin-Releasing ... Peptide Library N0000170686 Peptide Nucleic Acids N0000170384 Peptide PHI N0000167767 Peptide Synthases N0000170312 Peptide T ... Peptide Elongation Factor 1 N0000170085 Peptide Elongation Factor 2 N0000170086 Peptide Elongation Factor G N0000170088 Peptide ... Factor Tu N0000170083 Peptide Elongation Factors N0000011457 Peptide Fragments N0000011202 Peptide Hormones N0000005793 Peptide ...
... is a common precursor of melanocortin-related peptides in the pituitary and primarily regulated by corticotropin- releasing ... show that the forced inhibition of endogenous miR-375 in AtT-20 mouse pituitary tumor cells and in the intermediate lobe of the ... results show that miR-375 is highly expressed in the mouse pituitary gland and located specifically in the intermediate lobe of ... MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) ...
A8.713.357.750.500.500 Corticotropin-Like Intermediate Lobe Peptide D6.472.699.631.525.475.498 D6.472.699.631.525.600.498 ... N5.700.175.520 Occipital Lobe A8.186.211.730.885.213.571 A8.186.211.730.885.287.500.571 Oleanolic Acid D2.455.849.919.530.733 ... Intermediate A6.407.747.671 A6.407.747.750 A6.688.357.750.717 A6.688.357.750.750 A8.186.211.730.385.357.352.435.500.717 A8.186. ... Temporal Lobe A8.186.211.730.885.213.863 A8.186.211.730.885.287.500.863 Thalamic Nuclei A8.186.211.730.385.826.701 A8.186. ...
D4.210.500.745.745.654.237 Corticotropin-Like Intermediate Lobe Peptide D12.776.641.650.405.935.498 D12.776.631.650.405.935.498 ... Glucagon-Like Peptide Receptors D12.776.543.750.100.21 D12.776.543.750.695.21 Glucagon-Like Peptide-1 Receptor D12.776.543.750. ... Peptide Biosynthesis G2.111.87.675 G2.111.660 G2.149.115.675 G3.734 G3.495.770 Peptide Biosynthesis, Nucleic Acid-Independent ... Vasoactive Intestinal Peptide D12.776.543.750.100.900 D12.776.543.750.695.900 Receptors, Vasoactive Intestinal Peptide, Type II ...
... biosynthesis in the amphibian and mouse pituitary intermediate lobe. In: Melanotropic Peptides, Hadley, M.E. (Ed.), Boca Raton ... 1981) Processing, turnover and release of corticotropins, endorphins, and melanotropin in the toad pituitary. In: Peptides of ... Loh YP and Chang T-L (1982) Pro-opiocortin converting activity in rat intermediate and neural lobe secretory granules. FEBS ... Loh YP and Gritsch HA (1981) Evidence for intragranular processing of pro-opiocortin in the mouse pituitary intermediate lobe. ...
Corticotropin-Like Intermediate Lobe Peptide. Peptídeo da Parte Intermédia da Adenohipófise Semelhante à Corticotropina. ... Pituitary Gland, Intermediate. Adenohipófise Parte Intermédia. Adenohipófisis Porción Intermedia. Somatotrophs. Somatotrofos. ... D12 - Amino Acids, Peptides, and Proteins. 4-1BB Ligand. Ligante 4-1BB. Ligando 4-1BB. ... Glucagon-Like Peptide 2. Peptídeo 2 Semelhante ao Glucagon. Péptido 2 Similar al Glucagon. ...
Human CLIP(Corticotropin Like Intermediate Lobe Peptide) ELISA Kit. *Human CNTNAP2(Contactin Associated Protein Like Protein 2 ...
Human CLIP(Corticotropin Like Intermediate Lobe Peptide) ELISA Kit. *Human CNTNAP2(Contactin Associated Protein Like Protein 2 ... Human CLIP(Corticotropin Like Intermediate Lobe Peptide) ELISA Kit. *Human CNTNAP2(Contactin Associated Protein Like Protein 2 ... rhenium isotopes of sodium isotypes bio meaning peptides anti-aging peptidesciences peptides for skin peptides serum peptides ... Antimicrobial resistance of ocular microbes and the function of antimicrobial peptides * Mitochondrial-Focused Peptide, SS31, ...
Human CLIP(Corticotropin Like Intermediate Lobe Peptide) ELISA Kit. *Human CNTNAP2(Contactin Associated Protein Like Protein 2 ... Human CLIP(Corticotropin Like Intermediate Lobe Peptide) ELISA Kit. *Human CNTNAP2(Contactin Associated Protein Like Protein 2 ... cDNA / Devices / Enzymes / Equipments / Gels / Isotypes / Peptides Extreme-level Multiplexing in Digital PCR With Intercalating ... Devices / Enzymes / Equipments / Gels / Peptides Construction and evaluation of a pUC-type prokaryotic promoter reporter system ...
... of basal and regulated proopiomelanocortin-derived peptide secretion from fetal and neonatal pituitary intermediate lobe cells ... CRH, corticotropin-releasing hormone; VP, vasopressin. Color images are available online.. FIG. 5. ... The intermediate lobe of the pituitary, model of neuroendocrine communication]. Lamacz M, Tonon MC, Louiset E, Cazin L, Vaudry ... Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates cyclic AMP formation as well as peptide output of ...
Corticotropin-Like Intermediate Lobe Peptide Corticotropin-Releasing Hormone Corticoviridae Cortinarius Cortisone Cortisone ... Antigen Peptide Transporter-1 Antigen Peptide Transporter-2 Antigen Presentation Antigen-Antibody Complex Antigen-Antibody ... C-Peptide C-Reactive Protein C2 Domains Ca(2+) Mg(2+)-ATPase CA-125 Antigen CA-19-9 Antigen CA1 Region, Hippocampal CA2 Region ... Peptides, and Proteins Amino Acids, Sulfur Amino Acyl-tRNA Synthetases Amino Alcohols Amino Sugars Amino-Acid N- ...
Ans: Melanocyte-stimulating hormone (MSH) peptides are secreted exclusively by the intermediate lobe of the pituitary gland in ... Corticotropin is another name for ACTH.. *. Luteinising Hormone (LH) and Follicle-Stimulating Hormone (FSH): Gonadotropins are ... The -MSH peptide is made up of 13 amino acids that appear in the same order in all of the organisms studied. The duration and ... MSH, -MSH, and -MSH is the MSH peptide. They differ from one another in terms of their preferential binding to different ...
Corticotropin-like Intermediate Peptide (CLIP), Lipotropin Beta (β-LPH), Lipotropin Gamma (γ-LPH), Melanotropin Beta (β-MSH), ... POMC, ACTH and β-lipotropin are secreted from corticotropes in the anterior lobe (or adenohypophysis) of the pituitary gland in ... These fragments include NPP, Melanotropin Gamma (γ-MSH), Potential Peptide, Corticotropin (Adrenocorticotropic Hormone, or ACTH ... We investigated the central effect of ACTH 1-39 (ACTH) and peptides derived from the N-terminus (ACTH 1-10, Acetyl-ACTH 1-13- ...
Receptor Variant Enhances Alcohol Reward Molecules known as opioid peptides bind to opioid receptors in the brain to signal ... Compound Suppresses Stress-Related Drinking in Animals Corticotropin-releasing factor (CRF) is a neuropeptide that plays an ... RFA-AA-07-013 Animal Models of Endophenotypes and Intermediate Phenotypes for Alcohol Related Behaviors (RO1): 2 applications ... using the new technique were consistent with earlier research showing atrophy of brain tissue in the frontal and temporal lobes ...
Design and Synthesis of a Non-Peptide Small Molecule as an Imaging Tracer to Monitor the Corticotropin-Releasing Hormone (CRH) ... Quantification of 5-HT1A Receptors in Temporal Lobe Epilepsy (TLE) with PET and [18F]FCWAY: Effects of Modeling Methods on ... Kaposis Sarcoma-Associated Herpesvirus K8beta RNA is a Splicing Intermediate and Precursor of K8alpha ... Ion-pair Assisted Recovery: A Method to Obtain of MALDI-MS Signals from Protein/Peptide Mixtures Containing SDS ...
Samples and of the nicely, an intermediate aqueous layer, and an natural layer analyte stock solutions were stored at в€eighty ... Examples include barbiturates, carbamazepine, corticosteroids, corticotropin, mercaptopurine, nafcillin, hormonal ... secretion of peptide hor- mones). Screening urinalysis may usually determine persistent microhematuria which eventually ... The strap muscular tissues are anterior to the thyroid lobes, and the parathyroid glands and recurrent laryngeal nerves are ...
signal peptide, CUB domain, EGF-like 1 SCUBE3 signal peptide, CUB domain, EGF-like 3 ... kinase non-catalytic C-lobe domain (KIND) containing 1 KRT77 keratin 77, type II ... corticotropin releasing hormone CRHR1 corticotropin releasing hormone receptor 1 CRTAC1 cartilage acidic protein 1 ... internexin neuronal intermediate filament protein, alpha INSM2 insulinoma-associated 2 IQSEC3 IQ motif and Sec7 domain 3 ...
The intermediate lobe of the pituitary gland secretes only one enzyme that is melanocyte stimulating hormone. It is linked with ... Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the ... Adrenocorticotropic hormone release is triggered by corticotropin-releasing hormone and inhibited by rising glucocorticoid ...
... frontal lobe along with posterior left lobe, and constant speed shifting (slow or and varied) of the midbrain (right lobe) ... Rationale: The corticotropin-releasing hormone (CRH) stimulation test has been used as a diagnostic test in both adrenal ... The paleopallium or intermediate ("old mammalian") brain, comprising the structures of the limbic system. Note: This is study ... which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of ...
Peptides with morphine-like activity. AB - Two penta-peptides with morphine-like properties have recently been found in the ... lobe. Besides consolidated results given in the table, 2 cases (with pathology of the left and right frontal lobe) show ... Corticotropin increased the incorporation of labelled leucine into proteins within 4 h, but no effect was observed before 2 h ... The presence of the intermediate fraction between pre-beta- and beta lipoproteids is also found in the same animal by the ...
... lobe lobes,lobar lobes,lobe lobe,lobar lobe,lung field lobules,lobular lobule,lobular localisation,location localization, ... stomach peptides,peptide per centum,percent percentage body fat,body habitus percentage body fat,obesity percentage body fat, ... acth corticotropins,acth corticotropin,acth cortisols,cortisol cor,cardiac cor,heart costal,rib costal,ribs costa,rib ... matrix intermediate coronary syndrome,angina crescendo intermediate ischemic heart syndrome,angina crescendo intermenstrual ...
... lobe lobes,lobar lobes,lobe lobe,lobar lobe,lung field lobules,lobular lobule,lobular localisation,location localization, ... stomach peptides,peptide per centum,percent percentage body fat,body habitus percentage body fat,obesity percentage body fat, ... acth corticotropins,acth corticotropin,acth cortisols,cortisol cor,cardiac cor,heart costal,rib costal,ribs costa,rib ... matrix intermediate coronary syndrome,angina crescendo intermediate ischemic heart syndrome,angina crescendo intermenstrual ...
  • A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE , found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS . (nih.gov)
  • 3. Corticotrophin-like intermediary lobe peptide as a marker of alternate pro-opiomelanocortin processing in ACTH-producing non-pituitary tumours. (nih.gov)
  • 7. Corticotrophin-related peptides in the intermediate lobe of the rodent pituitary gland: characterization by high performance liquid chromatography and radioimmunoassay. (nih.gov)
  • 12. Post-translational processing of pro-opiomelanocortin (POMC)-derived peptides during fetal monkey pituitary development. (nih.gov)
  • 14. Proopiolipomelanocortin peptides in normal pituitary, pituitary tumor, and plasma of normal and Cushing's horses. (nih.gov)
  • 15. Characterization of eight forms of corticotropin-like intermediary lobe peptide from the rat intermediary pituitary. (nih.gov)
  • 16. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. (nih.gov)
  • 18. Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma. (nih.gov)
  • The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. (lookformedical.com)
  • Melanocyte-stimulating hormone refers to a group of peptide hormones released by the pituitary gland and hypothalamus. (vedantu.com)
  • The intermediate lobe of the pituitary gland secretes only one enzyme that is melanocyte stimulating hormone . (goto95.com)
  • N-terminal peptide of POMC or NPP). (lookformedical.com)
  • For example, the -MSH peptide is derived from the middle region of POMC, while -MSH is derived from the C-terminus (the carboxyl group-containing end) and -MSH is derived from the N-terminus (the end containing an amine group). (vedantu.com)
  • The peptide adrenocorticotropic hormone (ACTH) is another result of POMC cleavage, and it can be further cleaved to form alpha-MSH. (vedantu.com)
  • 9. The corticotropin-releasing hormone test in the diagnosis of ACTH-dependent Cushing's syndrome: a reappraisal. (nih.gov)
  • Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). (lookformedical.com)
  • The presence of apelin-immunoreactive nerve fibers, together with the detection of apelin receptor mRNA in the parvocellular part of the paraventricular nucleus and the stimulatory action of apelin on corticotropin-releasing hormone release, indicate that apelin modulates adrenocorticotropin (ACTH) release via an indirect action on the hypothalamus. (lookformedical.com)
  • We investigated the central effect of ACTH 1-39 (ACTH) and peptides derived from the N-terminus (ACTH 1-10, Acetyl-ACTH 1-13-amide [alpha-MSH]) and C-terminus (ACTH 18-39 and ACTH 22-39) of this peptide on feeding in 16 hour-fasted or rats fed ad libitum. (phoenixpeptide.com)
  • The N-terminal-derived peptide alpha-MSH, but not ACTH 1-10, reduced cumulative food intake over 2 h after its injection intracerebroventricularly (icv) in 16 h-fasted, but not in fed rats. (phoenixpeptide.com)
  • A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. (lookformedical.com)
  • Adrenocorticotropic hormone release is triggered by corticotropin -releasing hormone and inhibited by rising glucocorticoid levels. (goto95.com)
  • 1. Phosphorylated forms of adrenocorticotropin and corticotropin-like intermediary lobe peptide in human tumors. (nih.gov)
  • 2. Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors. (nih.gov)
  • 4. Phosphorylation of rat and human adrenocorticotropin-related peptides: physiological regulation and studies of secretion. (nih.gov)
  • The -MSH peptide is made up of 13 amino acids that appear in the same order in all of the organisms studied. (vedantu.com)
  • The ability of the MSH peptides to activate various MCRs is thought to be due to their different amino-acid sequences. (vedantu.com)
  • 13. Influence of a 1 h immobilization stress on sleep states and corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39, Ph-ACTH18-39) brain contents in the rat. (nih.gov)
  • 19. Characterization of immunoreactive corticotropin and corticotropin-releasing factor in human adrenal and ovarian tumours. (nih.gov)
  • Apelin is a bioactive peptide recently identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. (lookformedical.com)
  • 3. Corticotrophin-like intermediary lobe peptide as a marker of alternate pro-opiomelanocortin processing in ACTH-producing non-pituitary tumours. (nih.gov)
  • 7. Corticotrophin-related peptides in the intermediate lobe of the rodent pituitary gland: characterization by high performance liquid chromatography and radioimmunoassay. (nih.gov)
  • 12. Post-translational processing of pro-opiomelanocortin (POMC)-derived peptides during fetal monkey pituitary development. (nih.gov)
  • 14. Proopiolipomelanocortin peptides in normal pituitary, pituitary tumor, and plasma of normal and Cushing's horses. (nih.gov)
  • 15. Characterization of eight forms of corticotropin-like intermediary lobe peptide from the rat intermediary pituitary. (nih.gov)
  • 16. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. (nih.gov)
  • 18. Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma. (nih.gov)
  • A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE , found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS . (nih.gov)
  • Physiological peptide substrates are defined as those peptides whose endogenous levels of intact to cleaved forms are significantly different following genetic inactivation or chemical inhibition of DPP4 activity in vivo. (medscape.com)
  • There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. (nih.gov)
  • These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta opioid receptor (DOR) and kappa opioid receptor (KOR), and play important roles not only in analgesia, but also many other biological processes such as reward, stress response, feeding and emotion. (nih.gov)
  • The pharmacological functions of several endogenous opioid peptides through the mouse, rat and human OPRM1 7TM C -terminal variants have been considerably investigated together with various mu opioid ligands. (nih.gov)
  • The current review focuses on the studies of these endogenous opioid peptides and summarizes the results from early pharmacological studies, including receptor binding affinity and G protein activation, and recent studies of β-arrestin2 recruitment and biased signaling, aiming to provide new insights into the mechanisms and functions of endogenous opioid peptides, which are mediated through the OPRM1 7TM C -terminal splice variants. (nih.gov)
  • Peptides cleaved by DPP4 may be pharmacological or physiological substrates. (medscape.com)
  • 4. Phosphorylation of rat and human adrenocorticotropin-related peptides: physiological regulation and studies of secretion. (nih.gov)
  • 1. Phosphorylated forms of adrenocorticotropin and corticotropin-like intermediary lobe peptide in human tumors. (nih.gov)
  • 6. Biosynthesis of phosphorylated forms of corticotropin-related peptides. (nih.gov)
  • In contrast, studies in mice with disruption of single incretin receptors, or analysis of mice with combined genetic disruption of both the GIP and GLP-1 receptors (double incretin receptor knockout or DIRKO mice), strongly suggest that GIP and GLP-1 are the principal peptide substrates responsible for transducing the glucose-lowering actions of DPP-4 inhibitors (Figure 3). (medscape.com)

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