Corticotropin-Like Intermediate Lobe Peptide: A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS. Its sequence is identical to the C-terminal 22-amino acids of ACTH or ACTH 18-39.beta-Lipotropin: A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Pro-Opiomelanocortin: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).Pituitary Gland, Intermediate: The intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Melanotrophs: Neuroendocrine cells in the INTERMEDIATE LOBE OF PITUITARY. They produce MELANOCYTE STIMULATING HORMONES and other peptides from the post-translational processing of pro-opiomelanocortin (POMC).Melanocyte-Stimulating Hormones: Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Corticotropin-Releasing Hormone: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.Pituitary Hormones, Anterior: Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.Endorphins: One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.Pituitary Gland, Posterior: Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.

In-source decay characteristics of peptides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. (1/7)

In-source decay (ISD) of peptides, coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, has been examined to determine the influence of the matrix, the susceptibility of amino-acid residues to ISD, and the effect of extraction delay times. Out of nine di- and tri-hydroxybenzoic acids and three cinnamic derivatives tested, the most suitable matrix for ISD was 2,5-dihydroxybenzoic acid. The amine bond at Xxx-Gly and Xxx-Val residues was less susceptible than other amino-acid residues to ISD; however, the more sensitive residue(s) were not as clear. Using a peptide that gave the y(n)- and (z(n) + 2)-series product ions, it was confirmed that amide-bond cleavage (formation of the y(n)-series ions) accompanied metastable peaks, whereas metastable peaks were never observed with amine-bond cleavage [formation of the (z(n) + 2)-series ions]. Furthermore, abundant c(n)-series ions, which originate from amine-bond cleavage on the peptide backbone, were observed whenever a minimum delay time of 38 ns or continuous extraction was used to obtain spectra. These data indicate that amine-bond cleavage in ISD takes place on the ionization time scale before the energy randomization is completed.  (+info)

Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract. (2/7)

The alpha-melanocyte-stimulating hormone (alpha-MSH), derived from proopiomelanocortin (POMC), is generated by a posttranslational processing mechanism involving the prohormone convertases (PCs) PC1/3 and PC2. In the brain, alpha-MSH is produced in the arcuate nucleus (ARC) of the hypothalamus and in the nucleus of the solitary tract (NTS) of the medulla. This peptide is key in controlling energy balance, as judged by changes observed at transcriptional level. However, little information is available regarding the biosynthesis of the precursor POMC and the production of its processed peptides during feeding, fasting, and fasting plus leptin in the ARC compared with the NTS in conjunction with the PC activity. In this study we found that, in the ARC, pomc mRNA, POMC-derived peptides, and PC1/3 all decreased during fasting, and administration of leptin reversed these effects. In contrast, in the NTS, where there is a large amount of a 28.1-kDa peptide similar in size to POMC, the 28.1-kDa peptide and other POMC-derived peptides, including alpha-MSH, were further accumulated in fasting conditions, whereas pomc mRNA decreased. These changes were not reversed by leptin. We also observed that, during fasting, PC2 levels decreased in the NTS. These data suggest that, in the NTS, fasting induced changes in POMC biosynthesis, and processing is independent of leptin. These observations indicate that changes in energy status affect POMC in the brain in a tissue-specific manner. This represents a novel aspect in the regulation of energy balance and may have implications in the pathophysiology of obesity.  (+info)

Multiple feedback regulatory loops upon rat hypothalamic corticotropin-releasing hormone secretion. Potential clinical implications. (3/7)

To examine whether the hypothalamic corticotropin-releasing hormone (CRH) neuron is regulated by CRH, by products of the proopiomelanocortin (POMC) gene, and/or by glucocorticoids, we used a rat hypothalamic organ culture system in which rat CRH secretion from single explanted hypothalami was evaluated by an RIA (iCRH) specific for rat CRH. The effects of graded concentrations of ovine CRH (oCRH), adrenocorticotropin hormone (ACTH), beta-endorphin (beta-EP), alpha-melanocyte-stimulating hormone (alpha-MSH), corticotropin-like intermediate lobe peptide (CLIP), ovine beta-lipotropin (ovine beta-LPH), and dexamethasone (DEX) upon unstimulated and serotonin- (5HT), acetylcholine- (ACh), and norepinephrine-(NE) stimulated CRH secretion were determined. oCRH and DEX inhibited unstimulated iCRH secretion with ID50 at the 10(-8) M range. ACTH had no detectable suppressive effect at 10(-8) M. oCRH, ACTH, and DEX inhibited 5HT-, ACh-, and NE-stimulated iCRH secretion in a dose-dependent fashion. beta-EP, alpha-MSH, and CLIP also inhibited 5HT-induced iCRH secretion. Of the latter peptides, the strongest inhibitor was beta-EP and the weakest was CLIP. Ovine beta-LPH had only a weak inhibitory effect on 5HT-induced iCRH secretion. Generally, the concentrations required for 50% suppression of neurotransmitter-stimulated iCRH secretion were significantly lower than those required for a similar suppression of unstimulated iCRH secretion. In conclusion, these data suggest the presence of multiple negative feedback loops involved in the regulation of the hypothalamic CRH neuron: an ultrashort CRH-mediated loop, a short, hypothalamic POMC-derived peptide loop, and a long, glucocorticoid-mediated negative feedback loop. The potency of these negative feedback loops may be determined by the state of activation of the CRH neuron.  (+info)

Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. (4/7)

The proteolytic processing pattern of pro-ACTH/endorphin in rat hypothalamus is similar to the pattern in the pars intermedia; peptides the size of beta-endorphin, gamma-lipotropin (gamma-LPH), corticotropin-like intermediate lobe peptide (CLIP), alpha-melanotropin (gamma-MSH), joining peptide, and glycosylated gamma 3-MSH all represent predominant end products. Equimolar amounts of beta-endorphin-, alpha-MSH-, CLIP-, gamma-LPH-, and joining peptide-related immunoreactivity are found in hypothalamic extracts (approximately 3 pmol per hypothalamus). Although the proteolytic processing pattern in the hypothalamus is similar to that in the pars intermedia, a tissue-specific posttranslational processing pattern was detected. Ion-exchange analysis of beta-endorphin-sized immunoreactive material from hypothalamic extracts resolves three major forms, corresponding to beta-endorphin(1-31), beta-endorphin(1-27), and beta-endorphin(1-26). The alpha-N-acetylated forms of endorphin represent less than 10% of the total beta-endorphin immunoreactivity. Analyses of hypothalamic alpha-MSH-sized molecules with acetyl- and amide-directed alpha-MSH antisera suggest that hypothalamic alpha-MSH is fully amidated, but largely not alpha-N-acetylated. Fractionation by reverse-phase high-performance liquid chromatography (HPLC) confirms that greater than 85% of the alpha-MSH immunoreactivity corresponds to ACTH(1-13)NH2 or its sulfoxide, and less than 10% corresponds to alpha-MSH [alpha-N-acetyl-ACTH(1-13)NH2] or its sulfoxide. Isoelectric focusing demonstrates that 83-93% of hypothalamic CLIP is phosphorylated. Isoelectric focusing suggests that the majority of the hypothalamic gamma-LPH-sized immunoreactive material is indistinguishable from gamma-LPH synthesized by pituitary melanotropes. The minor extent of alpha-N-acetylation of alpha-MSH and beta-endorphin, the limited carboxyl-terminal proteolysis of beta-endorphin, and the extensive phosphorylation of CLIP represent major differences between the posttranslational processing patterns of pro-ACTH/endorphin in the hypothalamus and pars intermedia.  (+info)

Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. (5/7)

Naturally occurring derivatives of pro-opiomelanocortin (POMC) have been identified in various extra-pituitary sites, including the endocrine and exocrine pancreas. Corticotropin-like intermediate lobe peptide (CLIP = ACTH18-39), a naturally occurring derivative of POMC, has been suggested to be an insulin secretagogue. To determine whether CLIP might also affect the exocrine pancreas, we measured its effect on amylase secretion and protein synthesis and secretion in isolated rat pancreatic lobules. Lobules were dual-pulsed with trace amounts of 14C- and 3H-leucine, both in the presence and absence of CLIP (10(-9)-10(-6) M), using a technique that permitted the labeling of both the synthetic and secretory compartments. The effect of CLIP on protein synthesis was determined by comparing 3H-leucine incorporation into lobules with and without CLIP. The secretory effect of CLIP was determined by measuring (a) secreted 14C-labeled protein as a percent of total incorporated radiolabeled protein, and (b) amylase release into incubation medium. The effect of CLIP on amylase release was compared with that of secretin, cholecystokinin-octapeptide, and carbamylcholine. To localize the biologically active region of CLIP, we similarly studied synthetic ACTH25-39. We demonstrated that CLIP stimulates amylase and protein secretion in a dose-dependent manner and is of similar potency to secretin and carbamylcholine. This effect appears to require the ACTH18-24 region of CLIP and results from stimulus-secretion coupling rather than augmented protein synthesis. We also confirmed the presence of immunoreactive-adrenocorticotropic hormone (IR-ACTH) in rat pancreatic extract using a COOH-terminally directed antibody to ACTH1-39 and demonstrated that this IR-ACTH co-eluted with synthetic CLIP. These findings suggest that CLIP might be an endogenous modulator of pancreatic exocrine function.  (+info)

Biosynthesis of phosphorylated forms of corticotropin-related peptides. (6/7)

Phosphorylated forms of corticotropin[ACTH (1-39)], corticotropin-like intermediary lobe peptide[CLIP, ACTH (18-39)], and the common precursor for ACTH and beta-lipotropin (beta-LPH) have been identified in extracts of rat pituitaries, 32P-Labeled inorganic phosphate was successfully incorporated into ACTH (1-39), CLIP, and the ACTH/beta-LPH precursor in rat neurointermediary lobe explants and into ACTH (1-39) in isolated rat anterior pituitary cells. After peptidase digestion of the labeled CLIP and ACTH, the radioactive phosphate was recoverable as O-phosphoserine. The serine residue at position 31 was the only amino acid found to be phosphorylated in CLIP and ACTH (1-39). The unphosphorylated forms of both peptides were also synthesized. The demonstration of he incorporation of [32P]phosphate into CLIP, ACTH (1-39), and the ACTH/beta-LPH precursor is consistent with the hypothesis that, within the rat intermediary lobe, phosphorylated CLIP is derived from a phosphorylated form of the common precursor, with phosphorylated ACTH (1-39) acting as a biosynthetic intermediate.  (+info)

Characterization of eight forms of corticotropin-like intermediary lobe peptide from the rat intermediary pituitary. (7/7)

The isolation and characterization of eight forms of corticotropin-like intermediary lobe peptide (CLIP, adrenocorticotropin18-39) from the intermediary lobe of the rat pituitary has been accomplished by using reversed phase high performance liquid chromatography. The eight forms are the result of all combinations of the presence or absence of three post-translational modifications. These are glycosylation, phosphorylation, and removal of the carboxyl-terminal amino acid. The sites of phosphorylation and glycosylation are at serine 31 and asparagine 29, respectively. The eight forms (in order of elution from the reversed high performance liquid chromatography column) are glycosylated, phosphorylated CLIP18-38; glycosylated, nonphosphorylated CLIP18-38; nonglycosylated, phosphorylated CLIP18-38; nonglycosylated, nonphosphorylated CLIP18-38; glycosylated, phosphorylated CLIP18-39; glycosylated, nonphosphorylated CLIP18-39; nonglycosylated, phosphorylated CLIP18-39; and nonglycosylated, nonphosphorylated CLIP18-39.  (+info)

*Proopiomelanocortin

Corticotropin (Adrenocorticotropic Hormone, or ACTH Corticotropin-like Intermediate Peptide (CLIP) β-Lipotropin (β-LPH) Gamma ... while α-MSH secreted from the intermediate lobe of the pituitary regulates the production of melanin. ACTH is a peptide hormone ... The POMC gene is expressed in both the anterior and intermediate lobes of the pituitary gland. This gene encodes a 285-amino ... It is synthesized by: Corticotrope cells of the anterior pituitary gland Melanotrope cells of the intermediate lobe of the ...

*Corticotropin-like intermediate peptide

Peptides. 14 (6): 1221-4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304. Corticotropin-Like Intermediate Lobe Peptide at the ... Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), ... Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". ...

*Pituitary gland

... these three lobes are distinct.The intermediate is avascular and almost absent in human beings. The intermediate lobe is ... bombesin-like peptides (gastrin-releasing peptide, neuromedin B and C), and neurotensin, and inhibited by hypothalamic dopamine ... and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing hormone (CRH). ... This is also produced in the anterior lobe. When produced in the intermediate lobe, MSHs are sometimes called "intermedins". ...

*Adrenocorticotropic hormone

Glucocorticoids may also inhibit the rates of POMC gene transcription and peptide synthesis. The latter is an example of a slow ... POMC, ACTH and β-lipotropin are secreted from corticotropes in the anterior lobe (or adenohypophysis) of the pituitary gland in ... Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial ... many substances secreted within this axis exhibit slow/intermediate and fast feedback-loop activity. Glucocorticoids secreted ...

*Granulocyte

Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number of granules in an eosinophil can vary because ... Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes. ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... MCs contain numerous granules and secrete an abundance of prestored mediators such as corticotropin-releasing hormone (CRH), ...

*Granulocyte

Eosinophils also have kidney-shaped lobed nuclei (two to four lobes). The number of granules in an eosinophil can vary because ... Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes. Examples of ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... MCs contain numerous granules and secrete an abundance of prestored mediators such as corticotropin-releasing hormone (CRH), ...

*Endocrine system - Simple English Wikipedia, the free encyclopedia

Intermediate pituitary lobe (pars intermedia) *Melanocyte-stimulating hormone (MSH) Melanotroph. Thyroid[change , change source ... Atrial-natriuretic peptide (ANP) Cardiac myocytes. *Brain natriuretic peptide (BNP) Cardiac myocytes ... Corticotropin-releasing hormone (CRH) Parvocellular neurosecretory neurons. *Vasopressin Parvocellular neurosecretory neurons. ... Posterior pituitary lobe (neurohypophysis) *Oxytocin Magnocellular neurosecretory cells. *Vasopressin (AVP; also ADH, ...
Abbreviations AAG: α1-acid glycoprotein. AC: adenylyl cyclase. ACE: angiotensin-converting enzyme. ACh: acetylcholine. ACTH: corticotropin; formerly adrenocorticotropic hormone. ADH: antidiuretic hormone. ADME: absorption, distribution, metabolism, excretion. AT1: angiotensin II receptor, type 1. ATC: around the clock. BBB: blood-brain barrier. CaMK: Ca2+/calmodulin-dependent protein kinase. CDC: Centers for Disease Control and Prevention. CLIP: corticotropin-like intermediate lobe peptide. CNS: central nervous system. COPD: chronic obstructive pulmonary disease. COX: cyclooxygenase. CRH: corticotropin-releasing hormone. CSF: cerebrospinal fluid. CYP: cytochrome P450. DA: dopamine. DAMGO: [D-Ala2,MePhe4,Gly(ol)5]enkephalin. DHEA: dehydroepiandrosterone. DOR: δ opioid receptor. DYN: dynorphin. EEG: electroencephalogram. β-END: β-endorphin. L-ENK: Leu-enkephalin. ER/LA: extended-release/long-acting (a). FDA: Food and Drug Administration. FSH: follicle-stimulating hormone. GABA: γ-aminobutyric ...
BACKGROUND: There is an increasing interest in diet as a modifying factor in multiple sclerosis (MS), and gluten has been suggested to affect MS. OBJECTIVE: The aim of this systematic review is to qualitatively evaluate the evidence on the role of gluten in MS. METHODS: A review protocol was submitted to PROSPERO. A systematic literature search was conducted in PubMed, Web of Science, Scopus, Embase, Cab Abstracts, and Google Scholar. Studies on patients with MS, clinically isolated syndrome, or celiac disease presenting with MS-related markers were included, if they investigated effects of diets containing specified amounts of gluten or associations between gluten sensitivities and MS ...
Rio de Janeiro, Brazil, South America vacations: find accommodation, things to do, maps, attractions, hotels, photos, flights, weather, travel advice and more.,Canada travel online source for information including articles and features on tourism, accommodation, destination guides, Community, Tools and tips, dining, shopping, attractions, bookings, events, Trip Ideas, hotels, flights, vacation planning
Hyperplasia of Intermediate Lobe may be related to mutation in the Aryl Hydrocarbon Protein Gene in a Context of Familial Isolated Pituitary Adenoma (FIPA ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Preparation of the Pancreatic Lobules. After an overnight fast with free access to water, the animals were killed by cervical dislocation and the pancreatic lobules were obtained. The pancreatic lobules were prepared according to a method previously described [17]. In brief, the pancreas was quickly removed and immersed in modified calcium-free HEPES (25 mmol/L)-buffered Ringer solution with the following composition (Sigma-Aldrich, St. Louis, MO, USA): NaCl 113 mmol/L, HEPES 25 mmol/L, KCl 4.7 mmol/L, MgCl2 1.2 mmol/L, D-glucose 5.6 mmol/L, sodium pyruvate 5 mmol/L, sodium fumarate 5 mmol/L, sodium glutamate 5 mmol/L, and L-glutamine 2 mmol/L. The medium also contained 2% (v/v) essential amino acids, 1% (w/v) BSA, and 0.1% (w/v) soybean trypsin inhibitor. The solution was maintained at pH 7.4, while being continuously gassed with 100% O2 at 37 C. Whole pancreatic lobules were spread out by injecting calcium-free HEPES-Ringer solution gassed with 100% O2 into the loose connective tissue. The ...

Opioids, Analgesia, and Pain Management | Goodman & Gilmans: The Pharmacological Basis of Therapeutics, 13e | AccessPharmacy |...Opioids, Analgesia, and Pain Management | Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e | AccessPharmacy |...

CLIP: corticotropin-like intermediate lobe peptide. CNS: central nervous system. COPD: chronic obstructive pulmonary disease ... The term endorphin not only is used synonymously with endogenous opioid peptides but also refers to a specific endogenous ...
more infohttp://accesspharmacy.mhmedical.com/content.aspx?bookid=2189§ionid=170269577

Corticotropin-like intermediate peptide - WikipediaCorticotropin-like intermediate peptide - Wikipedia

Peptides. 14 (6): 1221-4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304. Corticotropin-Like Intermediate Lobe Peptide at the ... Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), ... Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on ... "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". ...
more infohttps://en.wikipedia.org/wiki/Corticotropin-like_intermediate_peptide

Frontiers | REM Sleep Rebound as an Adaptive Response to Stressful Situations | NeurologyFrontiers | REM Sleep Rebound as an Adaptive Response to Stressful Situations | Neurology

... corticotropin-like intermediate lobe peptide) and CLIP fragments on paradoxical sleep in rats. Peptides 15, 237-241. ... ACTH is metabolized originating corticotropin-like intermediate lobe peptide (CLIP), which is a major inducer of REMS. ... Moreover, ACTH derivatives - desacetyl-α-MSH and corticotropin-like intermediate lobe peptide (CLIP) induce, respectively, ... Influence of a 1 h immobilization stress on sleep states and corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39, ...
more infohttps://www.frontiersin.org/articles/10.3389/fneur.2012.00041/full

Frontiers | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound | EndocrinologyFrontiers | Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound | Endocrinology

Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved ... Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved ... Hypothalamic peptides (CRH, prolactin and the CLIP/ACTH18-39) play an important role in the expression of stress-induced sleep ... Hypothalamic peptides (CRH, prolactin and the CLIP/ACTH18-39) play an important role in the expression of stress-induced sleep ...
more infohttps://www.frontiersin.org/articles/10.3389/fendo.2016.00163/full

Biomarkers and acute brain injuries: interest and limits | Critical Care | Full TextBiomarkers and acute brain injuries: interest and limits | Critical Care | Full Text

... protein in clonal astroglioma cells is released by adrenocorticotropic hormone and corticotropin-like intermediate-lobe peptide ... Natriuretic peptides. Atrial natriuretic peptide and brain natriuretic peptide (BNP) are produced in the heart in response to ... and by adrenocorticotropic hormone and corticotrophin-like intermediate-lobe peptide [72]. Moreover, S100β protein is secreted ... ANP, atrial natriuretic peptide; ApoE, apolipoprotein E; BNP, brain natriuretic peptide; cTnI, cardiac troponin I; CRP, C- ...
more infohttps://ccforum.biomedcentral.com/articles/10.1186/cc13841

Code System ConceptCode System Concept

Corticotropin-like intermediate lobe peptide (substance). Code System Preferred Concept Name. Corticotropin-like intermediate ... Nervous system hormone-like substance (substance) {85860001 , SNOMED-CT } Peptide (substance) {52642002 , SNOMED-CT } ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=61795007

Pro-opiomelanocortin; POMC; Pro-OpiocortinPro-opiomelanocortin; POMC; Pro-Opiocortin

... corticotropin-like intermediate lobe peptide; N-terminal peptide of POMC or NPP). ... Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; ...
more infohttps://lookfordiagnosis.com/mesh_info.php?term=pro-opiomelanocortin&lang=1

DETERMINATION OF PRION PROTEIN (PrP) AND CHANGES IN FERTILITY HORMONES WITH SLEEP DEPRIVATION IN ALBINO RATS - Project TopicsDETERMINATION OF PRION PROTEIN (PrP) AND CHANGES IN FERTILITY HORMONES WITH SLEEP DEPRIVATION IN ALBINO RATS - Project Topics

CCIP Corticotropin Intermediate Lobe Peptide. *CCK Cholecystokinin. *CJD Creutzfeldt Jacobs Disease. *CNS Central Nervous ... Also the vasoactive intestinal peptide and peptide histidine isoleucine help to regulate prolactin secretion in humans, but the ... The frontal lobe of the brain keeps the body awake. It is the centre of planning, the memory search, motor control and ... For prion proteins, the cell surfaces were shown to trafic through the endocytic intermediates and this step was even shown to ...
more infohttps://www.projecttopics.org/determination-prion-protein-prp-changes-fertility-hormones-sleep-deprivation-albino-rats.html

Hypothalamus and Pituitary Gland | Greenspans Basic & Clinical Endocrinology, 10e | AccessBiomedical Science | McGraw-Hill...Hypothalamus and Pituitary Gland | Greenspan's Basic & Clinical Endocrinology, 10e | AccessBiomedical Science | McGraw-Hill...

Corticotropin-like intermediate lobe peptide. CRH. Corticotropin-releasing hormone. CRHBP. Corticotropin-releasing hormone- ... A single chemical messenger-peptide or amine-can be secreted by neurons as a neurotransmitter or neural hormone and by ... which regulate the hormone-secreting cells of the anterior lobe of the pituitary. Another example of neurosecretory regulation ...
more infohttps://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=2178§ionid=166247162

Medical | Page 9 | Full Form BookMedical | Page 9 | Full Form Book

... corticotropin-like intermediate lobe peptide , Childrens Longterm Inpatient Program ... CP Stands For : C peptide , C protein , caecal perforation , caeruloplasmin calcium phosphate , cancer patient , capillary ...
more infohttp://fullformbook.com/Medical?page=8

Proopiomelanocortin - WikipediaProopiomelanocortin - Wikipedia

Corticotropin (Adrenocorticotropic Hormone, or ACTH Corticotropin-like Intermediate Peptide (CLIP) β-Lipotropin (β-LPH) Gamma ... while α-MSH secreted from the intermediate lobe of the pituitary regulates the production of melanin. ACTH is a peptide hormone ... The POMC gene is expressed in both the anterior and intermediate lobes of the pituitary gland. This gene encodes a 285-amino ... It is synthesized by: Corticotrope cells of the anterior pituitary gland Melanotrope cells of the intermediate lobe of the ...
more infohttps://en.wikipedia.org/wiki/Proopiomelanocortin

Corticotropin-Releasing Hormone Immunoactivity - How is Corticotropin-Releasing Hormone Immunoactivity abbreviated?Corticotropin-Releasing Hormone Immunoactivity - How is Corticotropin-Releasing Hormone Immunoactivity abbreviated?

Looking for abbreviations of CRHI? It is Corticotropin-Releasing Hormone Immunoactivity. Corticotropin-Releasing Hormone ... Corticotropin-Releasing Hormone Receptor 1. *corticotropin-zinc hydroxide. *corticotropinlike intermediate-lobe peptide ... redirected from Corticotropin-Releasing Hormone Immunoactivity) Acronym. Definition. CRHI. Center for Rural Health Initiatives ... Corticotropin-Releasing Hormone Immunoactivity - How is Corticotropin-Releasing Hormone Immunoactivity abbreviated? https:// ...
more infohttp://acronyms.thefreedictionary.com/Corticotropin-Releasing+Hormone+Immunoactivity

Tony Howard - A new family of covalent inhibitors block nucleotide bindingTony Howard - A new family of covalent inhibitors block nucleotide binding

... corticotropin-like intermediate lobe peptide). The creation of MSH PSI-6206 takes a carboxypeptidase, PAM and an N- ... A critical function for peptide C-terminal amidation was apparent when the. A critical function for peptide C-terminal ... hydroxyglycine intermediate from the stereo-specific hydroxylation from the glycine-extended peptide precursor was suggested as ... Using a group of overlapping peptides spanning the complete XAGE-1b proteins, and to get the serological data, we discovered ...
more infohttp://bio-aromatica.com/author/administrator/

C - The Laminitis SiteC - The Laminitis Site

... corticotropin-like intermediate lobe peptide) or ACTH(18-39), a small biologically active peptide, was examined in the human ... CLIP - Corticotropin-like Intermediate Peptide. Corticotropin-like Intermediate Peptide (CLIP) is a POMC-derived peptide ... Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. J B ... Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain. ...
more infohttp://www.thelaminitissite.org/c.html

Biology, Geography & Health Research: Chapter 6360Biology, Geography & Health Research: Chapter 6360

S 100 protein in clonal astroglioma cells is released by acth and corticotropin like intermediate lobe peptide ... Tam J.P.; Heath W.F.; Merrifield R.B., 1983: S n2 de protection of synthetic peptides with a low concentration of hydrogen ... Cohen G.A.; O'connor R.D.; Hamburger R.N., 1984: Safety and efficacy of human immuno globulin e penta peptide ... Liakopoulou Kyriakides M.; Galardy R.E., 1979: S cis and s trans isomerism of the histidine proline peptide bond in angiotensin ...
more infohttps://eurekamag.com/research/006/359/

Cortisol:corticosterone ratio | definition of cortisol:corticosterone ratio by Medical dictionaryCortisol:corticosterone ratio | definition of cortisol:corticosterone ratio by Medical dictionary

corticotropinlike intermediate-lobe peptide. *corticotropinoma. *corticotropin-releasing factor. *corticotropin-releasing ...
more infohttps://medical-dictionary.thefreedictionary.com/cortisol%3Acorticosterone+ratio

Cortilymph | definition of cortilymph by Medical dictionaryCortilymph | definition of cortilymph by Medical dictionary

Corticotropin-Releasing Hormone Receptor 1. *corticotropin-zinc hydroxide. *corticotropinlike intermediate-lobe peptide ...
more infohttp://medical-dictionary.thefreedictionary.com/cortilymph

Neuroendocrine PerspectivesNeuroendocrine Perspectives

It focuses on four very rapidly evolving major topics: - the role of dopaminergic regulation of the intermediate pituitary lobe ... Dopaminergic Regulation of the Intermediate Pituitary.- Anatomy.- Innervation.- Dopaminergic Regulation of Intermediate Lobe ... Corticotropin Releasing Factor (Hormone): Physiological and Clinical Implications.- Corticotropin Releasing Factor and the ... intracellular signal transaction pathways and other regulatory mechanisms involved in transsynaptic regulation of peptide ...
more infohttps://www.moluna.de/buch/4190737-neuroendocrine+perspectives/

human endocrine system - Endocrine hyperfunction | anatomy | Britannica.comhuman endocrine system - Endocrine hyperfunction | anatomy | Britannica.com

pituitary gland, intermediate lobe. melanocyte-stimulating hormones (MSH)*. stimulate melanin synthesis in skin cells to ... pituitary gland, anterior lobe. corticotropin (adrenocorticotropin, ACTH). stimulates growth and secretion of cells of the ... vasoactive intestinal peptide (VIP). stimulates dilation of blood vessels and secretion of water and electrolytes from the ... corticotropin-releasing hormone (CRH). stimulates synthesis and secretion of corticotropin from the anterior pituitary gland. ...
more infohttps://www.britannica.com/science/human-endocrine-system/Endocrine-hyperfunction

Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in...Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in...

Corticotropin-releasing hormone (CRH) is a key regulator of POMC expression and the biological effects are mediated through its ... The POMC gene is predominantly expressed in the anterior and intermediate lobes of the pituitary and its mRNA has been detected ... Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999;885:312-28.View ArticlePubMedGoogle ... Solomon S. POMC-derived peptides and their biological action. Ann N Y Acad Sci. 1999;885:22-40.View ArticlePubMedGoogle Scholar ...
more infohttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0820-1

US Patent for Non-crosslinked protein particles for therapeutic and diagnostic use Patent (Patent #  5,616,311 issued April 1,...US Patent for Non-crosslinked protein particles for therapeutic and diagnostic use Patent (Patent # 5,616,311 issued April 1,...

Corticotropin-Like Intermediate Lobe Peptide. Corticotropin Releasing Factor and analogs. Tyr-Corticotropin Releasing Factor ... Adjuvant peptide (N-acetylmuramyl-1-alanyl-d-isoglutamine). 35. HIV-1 protease substrate (acetyl-ser-gln-asn-tyr-pro-val-val- ... In addition, the reduced TcO.sub.2.sup.- may first be stabilized by an intermediate product involving D-glucarate. ... Specific examples of particular interest are fibrinogen and peptides which contain reactive sequences of fibrinogen, such as ...
more infohttps://patents.justia.com/patent/5616311

WikiPremed MCAT Course - The Endocrine SystemWikiPremed MCAT Course - The Endocrine System

The melanocyte-stimulating hormones are a class of peptide hormones produced by cells in the intermediate lobe of the pituitary ... Corticotropin-releasing hormone. Corticotropin-releasing hormone stimulates corticotropes in the anterior pituitary to secrete ... Peptide hormone. Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions ... Brain natriuretic peptide. Brain natriuretic peptide is a polypeptide secreted by the ventricles of the heart in response to ...
more infohttp://www.wikipremed.com/mcat_course.php?code=040703

Anti-beta Endorphin antibody [B 31.15] (ab54205) | AbcamAnti-beta Endorphin antibody [B 31.15] (ab54205) | Abcam

ab54205, staining beta Endorphin in anterior (upper) and intermediate (lower) lobes of Wistar rat pituitary gland tissue by ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... ß-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). ß- ... Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous ...
more infohttp://www.abcam.com/beta-endorphin-antibody-b-3115-ab54205.html

pituitary glandpituitary gland

... these three lobes are distinct.The intermediate is avascular and almost absent in human beings. The intermediate lobe is ... bombesin-like peptides (gastrin-releasing peptide, neuromedin B and C), and neurotensin, and inhibited by hypothalamic dopamine ... and melanocyte-stimulating hormone are released under the influence of hypothalamic corticotropin-releasing hormone (CRH).[6][7 ... Intermediate lobe[edit]. Although rudimentary in humans (and often considered part of the anterior pituitary), the intermediate ...
more infohttps://en.wikipedia.org/wiki/Pituitary_gland

Endocrine system - wikidocEndocrine system - wikidoc

Intermediate pituitary lobe (pars intermedia). Secreted hormone. Abbreviation. From cells. Effect Melanocyte-stimulating ... Brain natriuretic peptide BNP. Cardiac myocytes. (To a minor degree than ANP) reduce blood pressure by: reducing systemic ... Corticotropin-releasing hormone CRH. Parvocellular neurosecretory neurons. Release ACTH from anterior pituitary ... Anterior pituitary lobe (adenohypophysis). Secreted hormone. Abbreviation. From cells. Effect Growth hormone GH. Somatotropes. ...
more infohttp://wikidoc.org/index.php/Endocrine
  • A single chemical messenger-peptide or amine-can be secreted by neurons as a neurotransmitter or neural hormone and by endocrine cells as a classic hormone. (mhmedical.com)
  • Beta-endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. (abcam.com)
  • Magno-cellular neurons are of two classes: those that secrete arginine vasopressin (AVP) and neurophysin II, and those that secrete oxytocin and neurophysin I. AVP often is colocalized with dynorphin or angiotensin II, whereas oxytocin frequently is colocalized with cholecystokinin (CCK), corticotropin-releasing hormone (CRH), metenkephalin, or proenkephalin. (wordpress.com)
  • Fink JS, Verhave M, Walton K, Mandel G, Goodman RH (1991) Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene. (springer.com)
  • Thus, the regulation of the so-called stress hormone clearly involves specific peptides synthesized and stored in the brain (i.e., corticotropin-releasing factor ((CRF) and arginine vasopressin (AVP)) and brain-derived neurotransmitters (i.e., noradrenaline). (doctorabel.us)
  • Development of the -hydroxyglycine intermediate from the stereo-specific hydroxylation from the glycine-extended peptide precursor was suggested as the first rung on the ladder in the response mediated by PAM (Youthful and Tamburini 1989). (bio-aromatica.com)
  • When fetal development is complete, the peptide-derived hormone oxytocin (tocia- = "childbirth") stimulates uterine contractions and dilation of the cervix. (openstax.org)
  • C-terminal valine amide neuropeptides constitute the smallest group of functional peptide compounds identified in neurosecretory structures in vertebrate and invertebrate species. (beds.ac.uk)
  • The α-amidation process is a highly specific enzyme-dependent post-translational modification need for converting prohormones into functional peptide products in neurosecretory cells. (beds.ac.uk)
  • These brain regions varied in the relative amount of putative novel valine amide peptide immunoreactive material (nmol/μg protein) estimated through a fmol-sensitive solid-phase radioimmunoassay (RIA) raised for P18C5 mAb. (beds.ac.uk)
  • Opioid bar of immunoreactive corticotropin-releasing factor leakage into the hypophysial-portal circulation of rats. (all-karelia.ru)
  • Alpha (α)-amidation of peptides is a mechanism required for the conversion of prohormones into functional peptide sequences that display biological activities, receptor recognition and signal transduction on target cells. (beds.ac.uk)
  • C-terminal amidation of peptides, a necessary step for the conversion of prohormones into functional products, is mediated by the activity of the peptidylglycine α-amidating monooxygenase (PAM), a type I membrane protein that is localized to the trans-Golgi network and to secretory granules in neural and endocrine tissues [ 6 ]. (beds.ac.uk)
  • This mAb offers a wide spectrum of potential applications in research and medicine, whose uses may extend from a biological reagent (used to detect valine amidated peptide substances in fluids and tissues) to a detoxifying reagent (used to neutralize exogenous toxic amide peptide compounds) or as a specific immunoreagent in immunotherapy settings (used to reduce tumor growth and tumorigenesis) among many others. (beds.ac.uk)
  • C.R. Harington, R.V. Pitt-Rivers, The synthesis of cysteine-(cystine-) tyrosine peptides and the action thereon of crystalline pepsin. (springer.com)
  • Stress is a major factor in drug relapse, and corticotropin-releasing factor (CRF) is key to the body's stress response. (newdrugs.com)
  • The role of glucocorticoids and the repressor isoform of cAMP response element (CRE) modulator (CREM), inducible cAMP early repressor (ICER), in limiting corticotropin-releasing hormone (CRH) transcription during restraint stress were examined in both intact and adrenalectomized rats receiving glucocorticoid replacement. (jneurosci.org)
  • 2002) Mice deficient for both corticotropin‐releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety‐like behavior. (els.net)
  • Neuro-adaptive changes occur as a consequence of excessive opioid exposure, including a recruitment of corticotropin-releasing factor (CRF) and norepinephrine (NE) brain stress systems. (readbyqxmd.com)
  • Corticotropin-releasing hormone (CRH) released during the stress response may suppress reproduction independent of downstream glucocorticoids. (deepdyve.com)
  • The balance of artificial peptides terminating having a COOH-terminal -hydroxyglyine residue was proven to decrease at pH ideals above 6, with half-lives of 8 h at pH7.4 (Bundgaard and Kahns 1991). (bio-aromatica.com)
  • G.W. Anderson, J. Blodinger, A.D. Welcher, Tetraethyl pyrophosphite as reagent in peptide synthesis. (springer.com)
  • Human C-peptide concentrations and in vivo glucose responsiveness demonstrated therapeutically relevant glycemic control and retrieved implants contained viable insulin-producing cells. (edu.au)
  • In support of the duplication-degeneration-complementation model of duplicate gene retention, partitioning of expression between grna and grnb was observed in the intermediate cell mass and yolk syncytial layer, respectively. (biomedcentral.com)
  • 65 year old man with progressive dyspnea and presumed COPD found to have lower lobe predominant panlobular emphysema from injecting Ritalin. (teachim.org)
  • The intermediate lobe is present in many lower animal species, in particular in rodents, mice and rats, that have been used extensively to study pituitary development and function. (wikipedia.org)
  • Kinetic constants of incretin hydrolysis by purified porcine kidney-derived enzyme and by human serum DP IV activity suggest that DP IV-mediated hydrolysis of these peptides is significant at physiological incretin concentrations. (ubc.ca)