Dictionaries, MedicalCorticotrophs: Anterior pituitary cells that produce ADRENOCORTICOTROPHIC HORMONE.Pro-Opiomelanocortin: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Ciliary Neurotrophic Factor Receptor alpha Subunit: A ciliary neurotrophic factor receptor subunit. It is anchored to the cell surface via GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and has specificity for binding to CILIARY NEUROTROPHIC FACTOR. It lacks signal transducing domains which are found on the other two subunits of the receptor.Receptors, Glucocorticoid: Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Lung Neoplasms: Tumors or cancer of the LUNG.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.NADH Tetrazolium Reductase: Catalyzes the reduction of tetrazolium compounds in the presence of NADH.Securin: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.Adenoma: A benign epithelial tumor with a glandular organization.Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Pituitary Diseases: Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.Hyperprolactinemia: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)Ergolines: A series of structurally-related alkaloids that contain the ergoline backbone structure.Bromocriptine: A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Pituitary Hormones: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.Pituitary Gland, Posterior: Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.Median Eminence: Raised area at the infundibular region of the HYPOTHALAMUS at the floor of the BRAIN, ventral to the THIRD VENTRICLE and adjacent to the ARCUATE NUCLEUS OF HYPOTHALAMUS. It contains the terminals of hypothalamic neurons and the capillary network of hypophyseal portal system, thus serving as a neuroendocrine link between the brain and the PITUITARY GLAND.Pituitary Hormones, Anterior: Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Endocrine System: The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.Endocrine Glands: Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.EncyclopediasTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Enhancer Elements, Genetic: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)Societies, Scientific: Societies whose membership is limited to scientists.
Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release. (1/20)Apelin is a bioactive peptide recently identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. The presence of apelin-immunoreactive nerve fibers, together with the detection of apelin receptor mRNA in the parvocellular part of the paraventricular nucleus and the stimulatory action of apelin on corticotropin-releasing hormone release, indicate that apelin modulates adrenocorticotropin (ACTH) release via an indirect action on the hypothalamus. However, a direct action of apelin in the anterior pituitary cannot be excluded. Here, we provided evidence for the existence of an apelinergic system within the adult male rat pituitary gland. Double immunofluorescence staining indicated that apelin is highly coexpressed in the anterior pituitary, mainly in corticotrophs (96.5 +/- 0.3%) and to a much lower extent in somatotropes (3.2 +/- 0.2%). Using in situ hybridization combined with immunohistochemistry, a high expression of apelin receptor mRNA was also found in corticotrophs, suggesting a local interaction between apelin and ACTH. In an ex vivo perifusion system of anterior pituitaries, apelin 17 (K17F, 10(-6) M) significantly increased basal ACTH release by 41%, whereas apelin 10 (R10F, 10(-6) M), an inactive apelin fragment, was ineffective. In addition, K17F but not R10F induced a dose-dependent increase in K(+)-evoked ACTH release, with maximal increase being observed for a 10(-6) M concentration. Taken together, these data outline the potential role of apelin as an autocrine/paracrine-acting peptide on ACTH release and provide morphological and neuroendocrine basis for further studies that explore the physiological role of apelin in the regulation of anterior pituitary functions. (+info)
Lack of annexin 1 results in an increase in corticotroph number in male but not female mice. (2/20)Annexin 1 (ANXA1) is a member of the annexin family of phospholipid- and calcium-binding proteins with a well demonstrated role in early delayed (30 min to 3 h) inhibitory feedback of glucocorticoids in the pituitary. We have examined corticotrophs in wild-type and ANXA1 knockout mice to determine the effects of lack of ANXA1 in male and female animals. Anterior pituitary tissue from ANXA1 wild-type, heterozygote and null mice was fixed and examined (i) by confocal immunocytochemistry to determine the number of corticotrophs and (ii) by electron microscopy to examine the size, secretory granule population and secretory machinery of corticotrophs. No differences in these parameters were detected in female mice. In male ANXA1 null mice, there were approximately four-fold more corticotrophs than in wild-type animals. However, the corticotrophs in ANXA1 null mice were smaller and had reduced numbers of secretory granules (the reduction in granules paralleled the reduction in cell size). No differences in the numerical density of folliculo-stellate, gonadotroph, lactotroph or somatotroph cells were detected in male ANXA1 null mice. Plasma corticosterone, adrenocorticotrophic hormone (ACTH) and pituitary pro-opiomelanocortin mRNA were unchanged but pituitary ACTH content was increased in male ANXA1 null mice. Interleukin (IL)-6 pituitary content was significantly elevated in male and reduced in female ANXA1 null mice compared to wild-type. In conclusion, these data indicate that ANXA1 deficiency is associated with gender-specific changes in corticotroph number and structure, via direct actions of ANXA1 and/or indirect changes in factors such as IL-6. (+info)
Cell-specific expression of X-linked inhibitor of apoptosis in the anterior pituitary of streptozotocin-induced diabetic rats. (3/20)Cell death is increased in the anterior pituitary of poorly controlled diabetic rats, but anti-apoptotic mechanisms are also activated. We hypothesized that specific cell types are selectively protected against diabetes-induced cell death. To determine when anti-apoptotic mechanisms are activated, streptozotocin-induced diabetic rats were killed after 1, 4, 6 and 8 weeks of evolution. Anterior pituitaries were processed for western blot analysis to determine changes in the intrinsic cell death pathway and upstream kinases involved in cell protection mechanisms. An increase in cell death was detected by ELISA at 4 weeks of diabetes. TUNEL labelling demonstrated that this corresponded to death of primarily lactotrophs, a few somatotrophs, and no thyrotrophs, corticotrophs or gonadotrophs. Levels of phosphorylated (p) Akt were increased at 1 week of diabetes, while pERK1/2 levels increased at 4 weeks and pJNK at 6 weeks. Activation of caspase 3 decreased and anti-apoptotic members of the Bcl-2 protein family increased as early as 1 week after diabetes onset. These changes were coincident with increased IGF-I receptor levels. Levels of X-linked inhibitor of apoptosis protein (XIAP) increased significantly after 6 weeks of diabetes, as did activation of nuclear factor (NF)kappaB. Double immunohistochemistry indicated that XIAP was expressed in less than 1% of lactotrophs and gonadotrophs, approximately 50% of somatotrophs and more than 90% of corticotrophs and thyrotrophs. These results suggest that some cell survival mechanisms are rapidly activated in the anterior pituitary, even before increased cell death can be detected, while others are more delayed. Furthermore, both pituitary cell death and expression of protective mechanisms such as XIAP are cell-type specific. (+info)
Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells. (4/20)Starvation is known to activate the hypothalamo-pituitary-adrenal (HPA) axis, a representative antistress system in the living organism. In this study, we investigated in vitro whether activation of the AMP-activated protein kinase (AMPK), which is known to occur in intracellular energy depletion, influences the expression of POMC gene that encodes adrenocorticotropin. We first confirmed that each subunit of AMPK was expressed in the AtT20 corticotroph cell line. We then found that AICAR, a cell-permeable AMP analog and an activator of AMPK, potently stimulated the 5'-promoter activity of POMC gene in a dose-dependent manner. The effects were promoter specific because AICAR enhanced the AP1-mediated POMC promoter activities but did not influence other transcription factor-induced transcription. The effect of AICAR on POMC gene transcription was completely eliminated by specific AMPK inhibitor compound C or by dominant negative AMPK, whereas overexpression of constitutively active AMPK mimicked the effect of AICAR. Finally, experiments using specific kinase inhibitors suggested that the PI 3-kinase-mediated signaling pathway is at least partly involved in the effect. Our results suggest that intracellular energy depletion with the resultant activation of AMPK directly stimulates the HPA axis at the pituitary level by increasing the expression of POMC gene. (+info)
Paracrinicity: the story of 30 years of cellular pituitary crosstalk. (5/20)Living organisms represent, in essence, dynamic interactions of high complexity between membrane-separated compartments that cannot exist on their own, but reach behaviour in co-ordination. In multicellular organisms, there must be communication and co-ordination between individual cells and cell groups to achieve appropriate behaviour of the system. Depending on the mode of signal transportation and the target, intercellular communication is neuronal, hormonal, paracrine or juxtacrine. Cell signalling can also be self-targeting or autocrine. Although the notion of paracrine and autocrine signalling was already suggested more than 100 years ago, it is only during the last 30 years that these mechanisms have been characterised. In the anterior pituitary, paracrine communication and autocrine loops that operate during fetal and postnatal development in mammals and lower vertebrates have been shown in all hormonal cell types and in folliculo-stellate cells. More than 100 compounds have been identified that have, or may have, paracrine or autocrine actions. They include the neurotransmitters acetylcholine and gamma-aminobutyric acid, peptides such as vasoactive intestinal peptide, galanin, endothelins, calcitonin, neuromedin B and melanocortins, growth factors of the epidermal growth factor, fibroblast growth factor, nerve growth factor and transforming growth factor-beta families, cytokines, tissue factors such as annexin-1 and follistatin, hormones, nitric oxide, purines, retinoids and fatty acid derivatives. In addition, connective tissue cells, endothelial cells and vascular pericytes may influence paracrinicity by delivering growth factors, cytokines, heparan sulphate proteoglycans and proteases. Basement membranes may influence paracrine signalling through the binding of signalling molecules to heparan sulphate proteoglycans. Paracrine/autocrine actions are highly context-dependent. They are turned on/off when hormonal outputs need to be adapted to changing demands of the organism, such as during reproduction, stress, inflammation, starvation and circadian rhythms. Specificity and selectivity in autocrine/paracrine interactions may rely on microanatomical specialisations, functional compartmentalisation in receptor-ligand distribution and the non-equilibrium dynamics of the receptor-ligand interactions in the loops. (+info)
Lipopolysaccharide stimulates proopiomelanocortin gene expression in AtT20 corticotroph cells. (6/20)While lipopolysaccharides (LPS) are known to activate the hypothalamo-pituitary-adrenal axis, their direct effects on proopiomelanocortin (POMC) and adrenocorticotropin (ACTH) expression at the pituitary level through Toll-like receptors (TLRs) remain unclear. In this study, we examined the effects of LPS on ACTH secretion and the transcription of the POMC gene in the AtT20 mouse pituitary corticotroph cell line. RT-PCR analysis showed that TLR1-4 and 6 subtype mRNAs were expressed in AtT20 cells. When the cells were treated with LPS, a significant increase in the 5'-promoter activity of POMC gene was observed at 24 h, without any stimulatory effect on ACTH secretion. LPS also stimulated the expression of c-Fos gene and protein, and AP1-, but not NF-kappaB-, mediated transcription. Overall, our data show the expression of TLRs in the pituitary corticotroph cells, and suggest the direct stimulatory effect of LPS on POMC gene expression via TLR (probably TLR4), although the intracellular signaling pathways in the corticotroph may be different from those in immune cells. (+info)
Immunohistochemical distribution of regulatory peptides in the human fetal adenohypophysis. (7/20)(+info)
Flow cytometry-assisted purification and proteomic analysis of the corticotropes dense-core secretory granules. (8/20)(+info)
Corticotroph adenomas are detected in more females than males. Therefore, Nelson's syndrome is observed in more females than ... Corticotroph adenomas are also detected in the younger population compared to the older population. Earlier, Nelson's syndrome ... Corticotrophinomas are generated from corticotroph cells. Expression of functional CRH and vasopressin V3 receptors increase in ...
Development of the endocrine system
Six weeks into gestation, the corticotroph cells can be identified. By seven weeks of gestation, the anterior pituitary is ...
2006). "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone ...
Vasopressin receptor 1B
"The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311-8 ...
2002). "Human lipocalin-1, a physiological scavenger of lipophilic compounds, is produced by corticotrophs of the pituitary ...
January 2006). "Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory ...
Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce melanocyte-stimulating hormone, ...
The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary, where four cleavage sites are used; ...
... the corticotrophs and melanotrophs. The Tpit gene is responsible for a neonatal form of acth deficiency and hypocortisolism. ...
Corticotropin-releasing hormone released from the hypothalamus stimulates corticotrophs in the anterior pituitary to release ...
... patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph ...
... and corticotrophs in the anterior pituitary gland, decreasing the amount of adrenocorticotropic hormone [ACTH]. For this reason ...
This translocation is dependent on protein kinase C. ANXA1 subsequently acts on the corticotrophs of the anterior pituitary, ...
... the corticotroph cells which produce adrenocorticotropic hormone (ACTH). It is described as such, as opposed to acidophil or ...
... and MIB-1 between human anterior and corticotroph cell "basophil invasion" of the posterior pituitary". The Journal of ...
Cushing's disease refers only to hypercortisolism secondary to excess production of ACTH from a corticotroph pituitary adenoma ...
2003). "Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a ...
ASTM E389 - 13 Standard Test Method for Particle Size or Screen Analysis at No. 4 (4.75-mm) Sieve and Coarser for Metal...
E389-13 Standard Test Method for Particle Size or Screen Analysis at No. 4 (4.75-mm) Sieve and Coarser for Metal-Bearing Ores and Related Materials screen analysis~ particle size~ metallic ores~
北京大学医学部机构知识库([email protected]): Effects of Apelin on RAW264.7 cells under both normal and hypoxic conditions
Macrophages are an important source of pro-inflammatory and pro-angiogenic factors, which can promote pathological processes involving inflammation and angiogenesis. This study investigated the effects of Apelin on macrophages under both normal and hypoxic conditions. Under normal culture conditions, Apelin down-regulated the mRNA expression levels of monocyte chemotactic protein 1 (MCP1), monocyte chemotactic protein 3 (MCP3), macrophage inflammatory protein 1 (MIP1 alpha, MIP1 beta), vascular endothelial growth factor A (VEGFA), Angiopoietin 2 (Ang2) and tumor necrosis factor alpha (TNF alpha). The supernatant concentrations of MCP1, MCP3, MIP1 alpha, MIP1 beta, macrophage inflammatory protein 2 (MIP2) and TNF alpha proteins were significantly decreased in the Apelin treated group. Hypoxia induced profound up-regulations of the angiogenic, chemokine, and inflammatory factors at both the mRNA and protein levels. Apelin suppressed the hypoxia-induced increases in MCP1, MCP3, MIP2, MIP1 beta and ...
HIV: Finding latent needles in a haystack - CD32 Commentary: CD32a is a marker for only 50% of reservoir....
As with any breakthrough, new questions arise and new experiments become feasible.....One problem, however, is that CD32a is a marker for only 50% of the reservoir, whereas the eradication of latent HIV would require a much greater reduction in the number of latently infected cells in the body. Moreover, targeting CD32a would also make the antigen-presenting cells that normally express CD32a vulnerable to destruction, which might well cause unwanted or harmful side effects.....Second, the authors studied CD4 lymphocytes from the blood, but these circulating cells account for 2%, at most, of the CD4 T cells in the body2. It remains to be seen whether CD32a is as good a marker for latently infected cells in the lymph nodes, bone marrow, gut and other tissues. Perhaps more markers could be identified from the 103 differentially expressed genes found in the researchers screen - analysis of these proteins in combination with CD32a might increase the total proportion of identifiable latent ...
Looking for online definition of corticotroph cell in the Medical Dictionary? corticotroph cell explanation free. What is corticotroph cell? Meaning of corticotroph cell medical term. What does corticotroph cell mean?
Looking for online definition of corticotrope in the Medical Dictionary? corticotrope explanation free. What is corticotrope? Meaning of corticotrope medical term. What does corticotrope mean?
Morfometrijska i imunohistohemijska analiza struktura adenohipofize uključenih u sistem hipotalamo-hipofizno-adrenalne osovine...
The aging in men is accompanied by an increase in the presence of connective tissue in all the organs and tissues, and with increase of corticotrophs and folliculostellate cells in adenohypophysis, which can affect the function of the HPA axis in healthy elderly individuals. Objective of the research was to perform quantification of structural changes during aging (cellularity, presence of the connective tissue and blood flow), collagen type IV, corticotrophs and folliculostellate cells on the pituitary tissue, obtained at autopsy, using histochemical, immunohistochemical and morphometric methods. Histochemical part of the research showed an increase of the cell size that occured during normal aging in the adenohypophysis. The analyzed cells of the adenohypophysis were significantly larger and, at the same time, they were characterized by a substantially more regular shape in female in comparison to the male patients cases. Differences in the cellular composition of the pituitary ...
Corticotroph releasing hormone (CRH) is one of the major regulatory hormones associated with the neuroendocrine response to stress. Pituitary corticotroph cells generate repetitive action potentials and associated Ca2+ transients in response to the agonist CRH. The mechanisms underlying this process are complex. CRH is known to activate the adenosine 3,5-cyclic monophosphate (cAMP)-dependent protein kinase A (PKA) pathway. PKA phosphorylates L-type voltage-sensitive Ca2+ channels, activating them and contributing to the generation of an action potential and Ca2+ transients. In an earlier Hodgkin-Huxley type mathematical model of this process, LeBeau et al. showed than an increase in the L-type current was sufficient to generate repetitive action potentials from a resting state in the model (LeBeau et al., 1997). However, they found that the action potential frequency of the model was much higher than the observed experimental action potential frequency. This problem was addressed in the ...
Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH ...
The involvement of excitatory amino acids in the control of ACTH release is well established. Activation of ionotropic glutamate receptors has a stimulatory effect on ACTH release, while the role of...
Sequence requirements for proinsulin processing at the B-chain/C-peptide junction | Biochemical Journal
Proinsulin is converted into insulin by the action of two endoproteases. Type I (PC1/PC3) is thought to cleave between the B-chain and the connecting peptide (C-peptide) and type II (PC2) between the C-peptide and the A-chain. An acidic region immediately C-terminal to the point of cleavage at the B-chain/C-peptide junction is well conserved throughout evolution and has been suggested to be important for proinsulin conversion [Gross, Villa-Komaroff, Kahn, Weir and Halban (1989) J. Biol. Chem. 264, 21486-21490]. We have here compared the precise role of this region as a whole and just the first acidic residue C-terminal to the point of cleavage in processing of proinsulin by PC3. To this end, several mutations were introduced in this region of human proinsulin (native sequence, B-chain RREAEDL C-peptide): RRPAEDL (C1Pro mutant); RRLAEDL (C1Leu mutant); RRL (C1-C4del mutant); RRE (del-C1Glu mutant). Mutant and native cDNAs were stably transfected into AtT20 (pituitary corticotroph) cells, in which ...
Semantic Scholar extracted view of [Chimeras from regulatory peptides as a device for studying their action]. by E. P. Kharchenko et al.
Rapid proteomic responses to a near-lethal heat stress in the salt marsh mussel Geukensia demissa | Journal of Experimental...
The universal response to cellular stress involves expression of chaperones to protect and refold proteins undergoing denaturation, or to send irretrievably damaged proteins into the ubiquitin-proteasome pathway for degradation. In addition, it has become clear that protection from oxidative stress is a component of the minimal stress proteome (Kültz, 2005), and oxidative stress proteins are often increased in abundance after heat stress, including in bivalves (Tomanek and Zuzow, 2010; Fields et al., 2012a). Stress proteins form a substantial portion of the proteomic response to acute heat exposure in G. demissa, but interestingly, changes in abundance do not appear immediately (i.e. at 0 h), instead becoming apparent at the 3 h time point.. Among the stress proteins increased in abundance at 3 h are GRP78, HSP24.1 and PPIase (Fig. 4A). GRP78 is an HSP70 analog found in the endoplasmic reticulum, where it has a central role in the unfolded protein response (Lai et al., 2010) and may help limit ...
Authors Abstract: COPYRIGHT 1999, John Wiley & Sons, Inc. The release of Ca(super 2+) from intracellular stores is an important trigger for secretion in many sell types. Depending on the spatial relationship between the intracellular Ca(super 2+) stores and the site of exocytosis, the Ca(super 2+) signal can be very local or spread throughout the entire cell. Here, we review how the release of Ca(super 2+) from inositol trisphospate (IP(sub 3))-sensitive stores contributes differently to the stimulus-secretion coupling in three types of secretory cells (acinar cells of the pancrease, gonadotrophs, and corticotrophs of the anterior pituitary gland). We propose that in both pancreatic acinar cells and pituitary gonadotrophs the IP(sub 3)-sensitive stores may be in close proximity to the sites of exocytosis such that the concentration of Ca(super 2+) at those sites are transiently much higher than the average cytosolic (Ca(sub 2+) concentration. In contract, the local Ca(super 2+) gradient is less ...
Species: Mouse Immunogen: Synthetic peptide corresponding to aa 1-24 of human ACTH (AH26); N-terminal fragment of human ACTH conjugated to KLH (57). Clone: AH26 & 57 Isotype: IgG1, kappa (AH26); IgG1, kappa (57). Species Reactivity: Human, Mouse, and Rat. Expected to show a broad species reactivity. Positive Control: Normal pituitary gland or pituitary tumor. Specificity: This antibody is specific to Synacthen (aa 1-24 of ACTH); this antibody does not react with CLIP (aa 17-39 of ACTH). Anti-ACTH is a useful marker in classification of pituitary tumors and in the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Status: ...
Combine the advantages of rationally designed shRNA with selectable promoters and reporters to perform functional screens of hundreds or thousands of shRNAs in dividing and non-dividing cells.
I Need to delete/unregistera ATT 5800 handset to replace a broken I am trying to replace a ATT 5800 handset with a - Lands Phones question
TY - JOUR. T1 - Apelin regulates the electrophysiological characteristics of atrial myocytes. AU - Cheng, Chen Chuan. AU - Weerateerangkul, Punate. AU - Lu, Yen Yu. AU - Chen, Yao Chang. AU - Lin, Yung Kuo. AU - Chen, Shih Ann. AU - Chen, Yi Jen. PY - 2013/1. Y1 - 2013/1. N2 - Backgroud: Apelin, a potential agent for treating heart failure, has various ionic effects on ventricular myocytes. However, the effects of apelin on the atrium are not clear. The purpose of this study was to investigate the acute effects of apelin on the electrophysiological characteristics of atrial myocytes. Method: Whole-cell patch-clamp techniques were used to investigate the action potential (AP) and ionic currents in isolated rabbit left atrial (LA) myocytes before and after the administration of apelin. Result: Apelin reduced LA AP duration measured at 90%, 50% and 20% repolarization of the amplitude by 11±3%, 24±5%, 30±7% at 1nM (n=11), and by 14±4%, 36±6% and 45±5% at 10nM (n=11), but not at 0·1nM. Apeline ...
2005) A Functional Screen Identifies Lateral Transfer of ß-Glucuronidase (gus) from Bacteria to Fungi - Cambia - Enabling...
Cambia means change.Cambia is an independent non-profit institute creating new technologies, tools and paradigms to promote change and enable innovation. ...
Forskare i Cederträ-Sinaien Samuel Oschin som Omfattande Cancer Instiftar upptäckt i pre-kliniskt, modellerar att dormant prostatacancerceller som finnas i bensilkespapper kan reawakeneds och att
För att uppmärksamma att Sveriges diplomatiska relationer med Japan firar 150 år under 2018 genomförs en särskild utlysning i samarbete mellan STINT och Riksbankens Jubileumsfond (RJ).. ...
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KBT vid samtidig somatisk sjukdom : KBT-terapeuters erfarenheter av att i psykiatrin möta patienter som lever med allvarlig och...
Studiens syfte var att undersöka erfarenheter hos psykoterapeuter inom psykiatrin av att bedriva KBT med patienter som samtidigt lever med kronisk och/eller allvarlig somatisk sjukdom. Detta utifrån frågeställningar om hur KBT-terapeuter beskriver hur samtidig allvarlig och/eller kronisk somatisk sjukdom påverkar det terapeutiska arbetet och hur terapeuterna förhåller sig till denna påverkan i relation till att genomföra terapin? Semistrukturerade intervjuer genomfördes med sex psykoterapeuter som alla hade KBT-inriktning och arbetade inom psykiatrin. En tematisk analys gjordes sedan av intervjuerna och där framkom huvudteman som följsamhet, helhetssyn och organisatorisk påverkan. Följsamhet till patienternas behov av anpassning gällde allt från längden på sessionerna till möjligheten att pausa terapin under vissa perioder. Att ha en helhetssyn kunde innebära att psykoterapeuten klev utanför sitt expertområde för att samarbeta med den somatiska vården kring en patient, ...
LifeMap Lösningar, Inc., en medicinsk teknologistart fokuserad på att skapa innovativa mobila vård- produkter (för mHealth) och servar drivit av stora data, meddelade i dag att en initial $5 miljon
Abstract 1475: The Apelin-APJ Pathway Is an Endogenous Regulator of Cardiac Function and Is Upregulated in Cardiac Pressure...
The inotropic and vasoactive properties of the ligand apelin and its cognate G-protein coupled receptor APJ have been characterized by administration of exogenous peptide, but the function of endogenous apelin on the cardiovascular system is not well described. To investigate the tonic effects of apelin-APJ in contractile function, we generated and characterized apelin and APJ null mice. We also investigated the regulation of apelin and APJ receptor expression in response to cardiac pressure overload. While knockout apelin mice were viable and fertile, APJ null mice showed evidence of fetal wastage for approximately half of the embryos. Compared to wild-type controls, APJ deficient mice reaching adulthood had significantly reduced exercise capacity (treadmill runtime: 20.30 ± 0.974 vs. 23.64 ± 0.737, P=0.009) and LV fractional shortening by echocardiography (29.88 ± 0.927% vs. 44.93 ± 2.66%, P,0.0001). Isolated myocytes from APJ knockouts exhibited reduced sarcomeric shortening (5.070 ± ...
The clinical success of targeted therapies along with technological advances in genome-wide profiling have spurred large-scale efforts to systematically map the molecular landscape of human cancers. These approaches nominate candidate essential or tumor suppressor genes, but are not able to identify all types of acquired vulnerabilities, such as synthetic lethal relationships between aberrantly regulated pathways.. Functional studies are therefore an essential complement to these approaches, serving both to confirm the biological roles of candidate cancer genes, and also to identify other vulnerabilities that are acquired as a consequence of observed genetic alterations.. Pooled short hairpin RNAi screening is proving to be a powerful method by which loss-of-function studies can identify new cancer targets. We are developing novel in vivo methods to identify genes which are essential for lung tumorigenesis, using mini-libraries of short hairpins against selected genes of interest.. ...
Att arbeta med ensamkommande flyktingbarn : En kvalitativ studie ur ett personalperspektiv på HVB-hem
Syftet med denna studie är att undersöka vilket stöd ensamkommande barn behöver vid ankomsten till Sverige utifrån personalens erfarenhet. Metoden är en kvalitativ studie som baseras utifrån intervjuer och litteraturkunskap för att få mer ingående och friare svar från intervjupersonerna. Huvudteman som framkom under intervjuerna är grundläggande behov, stödet som erbjuds, trygghet, föräldragestalter, utbildning, fritid och hinder i arbetet. Samtliga intervjupersoner beskriver ungdomarnas behov mycket olika då det skiljer sig från person till person. Det stöd barnen får är den viktigaste faktor som de ensamkommande barnen behöver för att kunna utvecklas och få ett bättre och tryggare liv. Resultatet visar att personalen har vetskap om all den kunskap som behövs för att kunna vara en bra förebild och en stödjande vuxen i barnens vardag. Det framkom tydligt hur relationen och tryggheten för de ensamkommande barnen är avgörande och ...
and so publications internetprofessional essay writersand after that items on-line Målgruppsanpassning av ett budskap är många gånger svårt att genomföra utan att trampa på någons ideologiska självkänsla. Jag tänker närmast på stora organisationers offentliga budskap, och framför allt i den offentliga sektorn. För att förtydliga lite tänkte jag ta några exempel på politiska budskap och hur dessa förmedlats till allmänheten, och hur de har bemötts internt.
Corticotroph cell | definition of corticotroph cell by Medical dictionary
What is corticotroph cell? Meaning of corticotroph cell medical term. What does corticotroph cell mean? ... Looking for online definition of corticotroph cell in the Medical Dictionary? corticotroph cell explanation free. ... corticotroph cell. Corticotroph.. cuboid cell. A cell - usually epithelial - with a height about equal to its width and depth. ... redirected from corticotroph cell). Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia. cell. (sel), 1. The ...https://medical-dictionary.thefreedictionary.com/corticotroph+cell
Prognostic significance of corticotroph staining in radiosurgery for non-functioning pituitary adenomas: a multicenter study |...
Silent corticotroph staining pituitary adenoma (SCA) represents an uncommon subset of Non-Functioning adenomas (NFAs), ... Xu Z, Ellis S, Lee CC, Starke RM, Schlesinger D, Lee Vance M et al (2014) Silent corticotroph adenomas after stereotactic ... Scheithauer BW, Jaap AJ, Horvath E, Kovacs K, Lloyd RV, Meyer FB et al (2000) Clinically silent corticotroph tumors of the ... Alahmadi H, Lee D, Wilson JR, Hayhurst C, Mete O, Gentili F et al (2012) Clinical features of silent corticotroph adenomas. ...https://link.springer.com/article/10.1007%2Fs11060-017-2520-y
Immunohistochemistry for transcription factor T-Pit as a tool in diagnostics of corticotroph pituitary tumours | SpringerLink
We have read with interest the recent review on silent corticotroph pituitary tumours published in the Pituitary . The ... Immunohistochemistry for transcription factor T-Pit is an essential tool in the diagnostics of corticotroph pituitary tumours ... The importance of T-Pit immunohistochemistry, especially in corticotroph pituitary tumours with sparse or no ACTH- ... Immunohistochemistry for transcription factor T-Pit as a tool in diagnostics of corticotroph pituitary tumours. ...https://link.springer.com/article/10.1007%2Fs11102-018-0879-1
Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor? | Springer for Research & Development
A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the ... A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the ... Felix I, Asa SL, Kovacs K, Horvath E. Changes in hormone production of a recurrent silent corticotroph adenoma of the pituitary ... Immunoreactive luteinizing hormone in functioning corticotroph adenomas of the pituitary. Immunohistochemical and tissue ...https://rd.springer.com/article/10.1007/BF02921343
Paediatric cyclical Cushing's disease due to corticotroph cell hyperplasia | springermedizin.de
... and is invariably due to a corticotroph adenoma, usually a microadenoma [ 1 ]. Corticotroph … ... Paediatric cyclical Cushings disease due to corticotroph cell hyperplasia Autoren:. E. Noctor S. Gupta T. Brown M. Farrell M. ... Paediatric cyclical Cushings disease due to corticotroph cell hyperplasia. Zeitschrift:. BMC Endocrine Disorders > Ausgabe 1/ ... Although uncommon, corticotroph hyperplasia causing Cushings syndrome has been described in the adult population, but appears ...https://www.springermedizin.de/paediatric-cyclical-cushing-s-disease-due-to-corticotroph-cell-h/9753896
Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report, Neurosurgery | 10.1097/00006123-199910000-00041 | DeepDyve
"Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report, Neurosurgery" on DeepDyve, the largest online rental service ... Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report. Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case ... Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report. Sanno, Naoko; Tahara, Shigeyuki; Yoshida, Yoichi; Onose, ... Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report. 914 Sanno et al. ment. If evidence of an ACTH-secretin • s ...https://www.deepdyve.com/lp/ou_press/ectopic-corticotroph-adenoma-in-the-cavernous-sinus-case-report-2zNNOwMPk4
Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas | Springer for Research &...
Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to ... Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas. ... Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature. Neurosurg. Focus 38, E17 ...https://rd.springer.com/article/10.1007%2Fs12020-018-1815-x
corticotrophs | Filipino Doctors
A mass that arises from the pituitary gland is called a pituitary adenoma. It is usually benign. It is classified based on the size of the mass and the type of cells that predominate in the tumor. These tumors can be functioning or nonfunctioning. Their function is based on the type of cells that comprise them. Tumors that are less than 10 mm in size are called pituitary microadenoma while those that are more than 10 mm are called pituitary macroadenoma. A pituitary microadenoma does not usually cause symptoms because they are small and they do not impinge on the » » » [Read more]. ...http://filipinodoctors.org/tag/corticotrophs/
KAKEN - Research Projects | Study on the gene abnormalities that cause glucocorticoid-resistant POMC gene expression in...
2) CRF-R1 mRNA levels were down-regulated by CRF in corticotrophs, but were up-regulated by CRF in corticotroph adenoma cells. ... 1) c-f os Gene expression of c-fos in corticotroph adenoma cells was greater than that in non-adenoma cells. There were 2 point ... Vib mRNA levels in corticotroph adenoma cells increased after stimulation of VP and CRF.The size of Vib mRNA in adenoma cells ... 3) DDAVP, V2-agonist, stimulated ACTH secretion from corticotroph adenoma cells, but did not stimulate it in normal ACTH cells ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671016/
Complete surgical removal of a very enlarged pituitary corticotroph adenoma in a dog | Advanced Veterinary Medical Imaging
Complete surgical removal of a very enlarged pituitary corticotroph adenoma in a dog. by Heather Hill , posted in: CT Concepts ... Pituitary transsphenoidal debulking surgery was performed and immunocytochemistry confirmed a corticotroph adenoma. The dog ...https://www.avmi.net/information/ct-concepts/complete-surgical-removal-of-a-very-enlarged-pituitary-corticotroph-adenoma-in-a-dog/
corticotroph adenoma case series [Operative Neurosurgery]
Corticotroph adenoma case series In a retrospective study 118 patients with Cushings syndrome (CS) [102 Cushings disease (CD ... corticotroph_adenoma_case_series. Corticotroph adenoma case series. In a retrospective study 118 patients with Cushings ... Among 50 cases of pituitary Corticotroph adenoma, 31 were vasopressin receptor 2 positive, 38 were vasopressin receptor 3 ... corticotroph_adenoma_case_series.txt. · Last modified: 2019/07/25 09:25 by administrador. ...https://operativeneurosurgery.com/doku.php?id=corticotroph_adenoma_case_series
Progression rate of silent corticotroph adenomas after stereotactic radiosurgery. In regard to Xu et al. - Semantic Scholar
Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study.. *Zhiyuan Xu. , Scott Ellis. , +5 authors. ... Progression rate of silent corticotroph adenomas after stereotactic radiosurgery. In regard to Xu et al.. *. Shao-Ching Chen. ... The role of mediators of cell invasiveness, motility, and migration in the pathogenesis of silent corticotroph adenomas.. * ... Predictors of silent corticotroph adenoma recurrence; a large retrospective single center study and systematic literature ...https://www.semanticscholar.org/paper/Progression-rate-of-silent-corticotroph-adenomas-a-Chen-Chung/5ca4e723b97d346016c22b70d54e4751161a006b
Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas<...
Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas. / Lim, Jung Soo; Lee, Mi ... Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas. Endocrine. 2019 Apr 1;64(1): ... Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas. In: Endocrine. 2019 ; Vol. 64 ... Methods: Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to ...https://yonsei.pure.elsevier.com/en/publications/hormonal-aggressiveness-according-to-the-expression-of-cellular-m
Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?<...
title = "Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?",. abstract = "A silent corticotroph adenoma ... Silent corticotroph adenoma with multiple cysts : Pars intermedia tumor? / Nishioka, Hiroshi; Hirano, Asao; Asa, Sylvia L. ... N2 - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the ... AB - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the ...https://einstein.pure.elsevier.com/en/publications/silent-corticotroph-adenoma-with-multiple-cysts-pars-intermedia-t-2
No mutations in TPIT, a corticotroph-specific gene, in human tumoral pituitary ACTH-secreting cells<...
Bucciarelli, L. G. ; Giraldi, F. Pecori ; Cavagnini, F. / No mutations in TPIT, a corticotroph-specific gene, in human tumoral ... Bucciarelli, L. G., Giraldi, F. P., & Cavagnini, F. (2005). No mutations in TPIT, a corticotroph-specific gene, in human ... No mutations in TPIT, a corticotroph-specific gene, in human tumoral pituitary ACTH-secreting cells. / Bucciarelli, L. G.; ... Bucciarelli, LG, Giraldi, FP & Cavagnini, F 2005, No mutations in TPIT, a corticotroph-specific gene, in human tumoral ...https://moh-it.pure.elsevier.com/en/publications/no-mutations-in-tpit-a-corticotroph-specific-gene-in-human-tumora
Suppressive effects of dehydroepiandrosterone and the nuclear factor-κB inhibitor parthenolide on corticotroph tumor cell...
We then examined the effects of DHEA and PRT on corticotroph tumor growth and function in vivo using xenografts of AtT20 cells ... Effects of DHEA and PRT on corticotroph cell function. (A) AtT20PL cells were treated with DHEA (100 μM) and/or PRT (7 μM), and ... Effects of DHEA and PRT on corticotroph cell function. (A) AtT20PL cells were treated with DHEA (100 μM) and/or PRT (7 μM), and ... Effects of DHEA and PRT on corticotroph cell function. (A) AtT20PL cells were treated with DHEA (100 μM) and/or PRT (7 μM), and ...https://joe.bioscientifica.com/view/journals/joe/188/2/1880321.xml
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease. - PubMed - NCBI
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushings disease.. Hayashi K1, Inoshita ... Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph ... USP8 mutations as well as clinicopathological characteristics were examined in 60 corticotroph adenomas including 15 Crookes ...https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=121408
HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas. - PubMed - NCBI
HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas.. Evang JA1, Borota OC, ... This study aimed to examine HDAC2 expression in a Norwegian cohort of corticotroph adenomas, screen for exonic HDAC2 gene ... Strongly reduced HDAC2 protein expression was confirmed in a small portion of corticotroph tumours. Mutations in HDAC2 exons ... and lack of nuclear expression of HDAC2 has previously been shown in some human and canine corticotroph adenomas. ...https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=51926
Neurosecretory cell | definition of neurosecretory cell by Medical dictionary
corticotroph cell. Corticotroph.. cuboid cell. A cell - usually epithelial - with a height about equal to its width and depth. ...https://medical-dictionary.thefreedictionary.com/neurosecretory+cell
Pituitary disease: presentation, diagnosis, and management | Journal of Neurology, Neurosurgery & Psychiatry
CORTICOTROPH ADENOMAS. Diagnosis. The lack of specificity of many of the phenotypic characteristics of Cushings syndrome ( ...http://jnnp.bmj.com/content/75/suppl_3/iii47
Pathology Flashcards by Daniel Part | Brainscape
Corticotrophs -> ACTH (20%). - Thyrotrophs -> TSH (5%). - Gonadotrophs -> FSH/LH (5%). Chromophobe 79 ...https://www.brainscape.com/flashcards/pathology-4994963/packs/7378807
Treatment of Functional (Hormone-Making) Pituitary Tumors
Treatment of corticotroph or corticotropin (ACTH)-secreting adenomas. These tumors cause the adrenal glands to make too much of ...https://www.cancer.org/cancer/pituitary-tumors/treating/functional-tumors.html
Endocrine System | Adrenal Gland (342 views)
Corticotroph (ACTH) Corticotropin releasing. hormone(CRH) ---------. Corticotroph (MSH) Corticotropin releasing. hormone(CRH) ... thyrotrophs, gonadotrophs, lactotrophs and corticotrophs-secrete seven hormones. Anterior pituitary cells Releasing hormone ...https://www.scribd.com/document/8966601/Endocrine-System
The Pituitary - 4th Edition
Corticotroph Biology. *Proopiomelanocortin Gene. *Regulation of the HPA Axis. *Effects of Secreted POMC-Derived Peptides in ...https://www.elsevier.com/books/the-pituitary/melmed/978-0-12-804169-7?start_rank=1&sortby=sortByDateDesc&cat0=medicine&cat1=endocrinology
Hypothalamus-Pituitary Relationship Flashcards by Steven Marincel | Brainscape
Study Hypothalamus-Pituitary Relationship flashcards from Steven Marincelhttps://www.brainscape.com/flashcards/hypothalamus-pituitary-relationship-5064070/packs/7486585
- Although uncommon, corticotroph hyperplasia causing Cushing's syndrome has been described in the adult population, but appears to be extremely rare in children. (springermedizin.de)
- This report describes a rare case of cyclical Cushing's disease secondary to corticotroph hyperplasia in a paediatric patient. (springermedizin.de)
- Haap M, Gallwitz B, Meyermann R, Mittelbronn M. Cushing's disease associated with both pituitary microadenoma and corticotroph hyperplasia. (springermedizin.de)
- Conclusions: Aberrant TPIT is unlikely to play a role in corticotroph tumoral trasformation, ie, Cushing's disease, as the entire coding sequence is expressed without any mutation by human pituitary ACTH-secreting adenomas. (elsevier.com)
- 2001) showed that retinoic acid, an inducer of cell differentiation, has potent inhibitory effects on Cushing's adenoma using AtT20 mouse corticotroph tumor cells as a model system. (bioscientifica.com)
- The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease. (cdc.gov)
- Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph adenomas of Cushing's disease (CD). (cdc.gov)
- Xu Z, Ellis S, Lee CC, Starke RM, Schlesinger D, Lee Vance M et al (2014) Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. (springer.com)
- Progression rate of silent corticotroph adenomas after stereotactic radiosurgery. (semanticscholar.org)
- Silent corticotroph adenomas after stereotactic radiosurgery: a case-control study. (semanticscholar.org)
- Immunohistochemistry for transcription factor T-Pit is an essential tool in the diagnostics of corticotroph pituitary tumours with sparse or no ACTH immunolabeling. (springer.com)
- 3) DDAVP, V2-agonist, stimulated ACTH secretion from corticotroph adenoma cells, but did not stimulate it in normal ACTH cells. (nii.ac.jp)
- As with other transcription factors, TPIT could theoretically also be involved in corticotroph adenomatous transformation and ACTH hypersecretion and published data indicate that TPIT is present in normal and adenomatous human corticotrophs. (elsevier.com)
- Silent corticotroph adenoma (SCA) is a non-functioning macroadenoma that has positive immunoreactivity for ACTH. (nel.edu)
- Silent corticotroph staining represents an independent factor for adenoma progression and hypopituitarism after SRS. (springer.com)
- Kovacs K, Horvath E, Bayley TA, Hassaram ST, Ezrin C (1978) Silent corticotroph cell adenoma with lysosomal accumulation and crinophagy. (springer.com)
- The review provides an update on pathogenesis, molecular biology and clinical behaviour of the silent corticotroph tumours, recognised by the 2017 WHO classification of pituitary tumours as a subtype with potentially more-aggressive behaviour. (springer.com)
- In the introduction, the authors comment on immunohistochemistry with anti-T-Pit antibody that may result in reclassification of a subset of clinically non-functioning pituitary neuroendocrine tumours as silent corticotroph tumours. (springer.com)
- The antibody demonstrated distinct nuclear immunolabeling in tumour cells of corticotroph tumours, both hormone-producing and clinically silent. (springer.com)
- Ben-Shlomo A, Cooper O (2018) Silent corticotroph adenomas. (springer.com)
- Felix I, Asa SL, Kovacs K, Horvath E. Changes in hormone production of a recurrent silent corticotroph adenoma of the pituitary. (springer.com)
- The role of mediators of cell invasiveness, motility, and migration in the pathogenesis of silent corticotroph adenomas. (semanticscholar.org)
- Biochemical behaviour of an incidentally diagnosed silent corticotroph adenoma. (nel.edu)
- s Ectopic Corticotroph Adenoma in the adenoma is convincing but the existence of a tumor cannot be confirmed using Cavernous Sinus: Case Report imaging studies or during surgery, a hem ihypophysectom y or total hypophy- sectomy is sometimes performed. (deepdyve.com)
- Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to immunohistochemical study using the following antibodies: pituitary tumor-transforming gene 1 (PTTG1), cyclin D1, p16, p27, brahma related-gene 1 (Brg1), and Ki-67. (springer.com)
- To clarify the possible inhibitory action of DHEA on pituitary tumor cells, we tested the effects of DHEA, alone or in combination with the nuclear factor-κB (NF-κB) inhibitor parthenolide (PRT), on AtT20 corticotroph cell growth and function both in vitro and in vivo . (bioscientifica.com)
- Altogether, these results suggested that combined treatments of DHEA and PRT potently inhibit the growth and function of corticotroph tumor cells both in vitro and in vivo . (bioscientifica.com)
- Sjöstedt E, Bollerslev J, Mulder J, Lindskog C, Pontén F, Casar-Borota O (2017) A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours. (springer.com)
- Strongly reduced HDAC2 protein expression was confirmed in a small portion of corticotroph tumours. (cdc.gov)
- Objective: The aim of the present study was to corroborate this finding and to seek evidence for mutations in the TPIT coding sequence in human tumoral corticotrophs. (elsevier.com)
- USP8 mutations as well as clinicopathological characteristics were examined in 60 corticotroph adenomas including 15 Crooke's cell adenomas (CCAs), a rare histological variant presenting with generally aggressive behavior, using qRT-PCR and/or immunohistochemistry. (cdc.gov)
- Mutations in HDAC2 exons are unlikely to play an important role in the development of corticotroph adenomas. (cdc.gov)