Corticosterone
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Pituitary-Adrenal System
Hypothalamo-Hypophyseal System
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
Restraint, Physical
Adrenal Glands
Stress, Physiological
Metyrapone
Corticotropin-Releasing Hormone
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Receptors, Glucocorticoid
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Mifepristone
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Receptors, Mineralocorticoid
Rats, Sprague-Dawley
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Adrenal Cortex
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Rats, Wistar
11-beta-Hydroxysteroid Dehydrogenases
Handling (Psychology)
Steroid 11-beta-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Hormone Antagonists
Body Weight
Swimming
Aldosterone
Hydroxysteroid Dehydrogenases
11-beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Circadian Rhythm
Pro-Opiomelanocortin
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
11-beta-Hydroxysteroid Dehydrogenase Type 1
Hippocampus
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Hypothalamus
Ether
Drug Implants
Receptors, Corticotropin-Releasing Hormone
Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.
Neurosecretory Systems
Analysis of Variance
Desoxycorticosterone
Exploratory Behavior
Mineralocorticoids
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Hydrocortisone
Maze Learning
Immobilization
Hormones
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Anxiety
Amygdala
Cortodoxone
Rats, Inbred Strains
Aldosterone Synthase
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Zona Reticularis
Zona Fasciculata
Cortisone
Dose-Response Relationship, Drug
Feathers
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Social Isolation
Sparrows
Solar Activity
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Hydroxyprogesterones
Biogenic Monoamines
Oviparity
Arginine Vasopressin
Carbenoxolone
Electroshock
Pituitary Gland
Disease Models, Animal
Nesting Behavior
Hypophysectomy
Phenelzine
Feeding Behavior
Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (1/3099)
In Balb/c mice with pulmonary tuberculosis, there is a switch from a protective Th1-dominated cytokine profile to a non-protective profile with a Th2 component. This switch occurs while the adrenals are undergoing marked hyperplasia. Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective. We investigated the effects of these hormones as therapeutic agents by administering them from day 60, when the switch to the non-protective cytokine profile was already well established. Given at this time (day 60), doses that were protective when given early (from day 0) were rapidly fatal. A physiological dose of the glucocorticoid corticosterone was also rapidly fatal. However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha. Therefore this combination of steroids has an emergent property that is quite unlike that of either type of steroid given alone. It may be possible to exploit the ant-inflammatory properties of glucocorticoids while preserving a Th1 bias, by combining glucocorticoids with DHEA or suitable metabolites. (+info)Maternal adrenocortical hormones maintain the early development of pancreatic B cells in the fetal rat. (2/3099)
To investigate the effect of maternal adrenocortical hormones on the development of fetal pancreatic islet cells, pregnant rats were adrenalectomised on d 6 of gestation. On d 12-16 the growth patterns of fetal insulin-producing B cells, glucagon-producing A cells, and somatostatin-producing D cells were observed histometrically. Maternal adrenalectomy resulted in growth retardation of fetal B cells on d 12-15. Maternal corticosterone therapy prevented this retardation. Maternal adrenalectomy, however, did not affect the developmental patterns of A and D cells. By Western blotting and immunohistochemistry, glucocorticoid receptors were demonstrated to be present in the islet cells from d 12 to d 15. These results suggest that maternal adrenocortical hormones, glucocorticoids in particular, maintain the early development of fetal pancreatic B cells through their specific intracellular glucocorticoid receptor. (+info)The Ca2+ channel blockade changes the behavioral and biochemical effects of immobilization stress. (3/3099)
We investigated how the effects of chronic immobilization stress in rats are modified by Ca2+ channel blockade preceding restraint sessions. The application of nifedipine (5 mg/kg) shortly before each of seven daily 2 h restraint sessions prevented the development of sensitized response to amphetamine as well as the stress-induced elevation of the densities of L-type Ca2+ channel in the hippocampus and significantly reduced the elevation of the densities of [3H]nitrendipine binding sites in the cortex and D1 dopamine receptors in the limbic forebrain. Neither stress, nor nifedipine affected the density of alpha 1-adrenoceptors and D1 receptors in the cerebral cortex nor D2 dopamine receptors in the striatum. A single restraint session caused an elevation of blood corticosterone level that remained unaffected by nifedipine pretreatment, but the reduction of this response during the eighth session was significantly less expressed in nifedipine-treated rats. We conclude that L-type calcium channel blockade prevents development of several stress-induced adaptive responses. (+info)Relationships between environmental organochlorine contaminant residues, plasma corticosterone concentrations, and intermediary metabolic enzyme activities in Great Lakes herring gull embryos. (4/3099)
Experiments were conducted to survey and detect differences in plasma corticosterone concentrations and intermediary metabolic enzyme activities in herring gull (Larus argentatus) embryos environmentally exposed to organochlorine contaminants in ovo. Unincubated fertile herring gull eggs were collected from an Atlantic coast control site and various Great Lakes sites in 1997 and artificially incubated in the laboratory. Liver and/or kidney tissues from approximately half of the late-stage embryos were analyzed for the activities of various intermediary metabolic enzymes known to be regulated, at least in part, by corticosteroids. Basal plasma corticosterone concentrations were determined for the remaining embryos. Yolk sacs were collected from each embryo and a subset was analyzed for organochlorine contaminants. Regression analysis of individual yolk sac organochlorine residue concentrations, or 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQs), with individual basal plasma corticosterone concentrations indicated statistically significant inverse relationships for polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDDs/PCDFs), total polychlorinated biphenyls (PCBs), non-ortho PCBs, and TEQs. Similarly, inverse relationships were observed for the activities of two intermediary metabolic enzymes (phosphoenolpyruvate carboxykinase and malic enzyme) when regressed against PCDDs/PCDFs. Overall, these data suggest that current levels of organochlorine contamination may be affecting the hypothalamo-pituitary-adrenal axis and associated intermediary metabolic pathways in environmentally exposed herring gull embryos in the Great Lakes. (+info)Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. (5/3099)
We have examined neuroanatomical, biochemical and endocrine parameters and spatial learning in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) during ageing. Aged beta2(-/-) mutant mice showed region-specific alterations in cortical regions, including neocortical hypotrophy, loss of hippocampal pyramidal neurons, astro- and microgliosis and elevation of serum corticosterone levels. Whereas adult mutant and control animals performed well in the Morris maze, 22- to 24-month-old beta2(-/-) mice were significantly impaired in spatial learning. These data show that beta2 subunit-containing nAChRs can contribute to both neuronal survival and maintenance of cognitive performance during ageing. beta2(-/-) mice may thus serve as one possible animal model for some of the cognitive deficits and degenerative processes which take place during physiological ageing and in Alzheimer's disease, particularly those associated with dysfunction of the cholinergic system. (+info)High-temperature effects on antibody response to viral antigen in mice. (6/3099)
To determine the effects of high-temperature exposure on antibody response to viral antigen in mice, male BALB/c mice were placed for 13 days in animal chambers at 23 degrees C, 32 degrees C, and 35.5 degrees C. Rectal temperature rose from 37 degrees C to 39 degrees C on day 1 in a 35.5 degrees C environment. The rectal temperature was kept constant throughout the exposure period. The IgG-antibody to Sendai virus (SV) antigen was inhibited to about 50% of the control value (23 degrees C). The serum corticosterone concentration indicating thermal stress increased steadily, peaking on day 1 and then gradually decreased and recovered to the normal level on day 13. Body weight decreased to about 72% of the controls on day 13. Thymus and spleen weight decreased to 31.7% and 61.5% respectively. At 32 degrees C, these effects were less than at 35.5 degrees C. Effects of high-temperature exposure at 35.5 degrees C appeared to noticeably decrease thymus and spleen weight. It is clear that IgG-antibody response to SV antigen is suppressed by high-temperature exposure. (+info)Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. (7/3099)
Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6 (rrIL-6) on the induction of hypothalamic-pituitary-adrenal (HPA) activity, fever, social investigatory behavior, and immobility. After intracerebroventricular administration of rrIL-6 (50 or 100 ng/rat), rats demonstrated HPA and febrile responses. In contrast, rrIL-6 alone did not induce changes in social investigatory and locomotor behavior at doses of up to 400 ng/rat. Coadministration of rrIL-6 (100 ng/rat) and rrIL-1beta (40 ng/rat), which alone did not affect the behavioral responses, reduced social investigatory behavior and increased the duration of immobility. Compared with rhIL-6, intracerebroventricular administration of rrIL-6 (100 ng/rat) induced higher HPA responses and early-phase febrile responses. This is consistent with a higher potency of rrIL-6, compared with rhIL-6, in the murine B9 bioassay. We conclude that species-homologous rrIL-6 alone can act in the brain to induce HPA and febrile responses, whereas it only reduces social investigatory behavior and locomotor activity in the presence of IL-1beta. (+info)Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. (8/3099)
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and hypertension. However, the disorder is usually incompletely corrected by suppression of cortisol, suggesting additional and irreversible changes, perhaps in the kidney. To examine this further, we produced mice with targeted disruption of the 11beta-HSD2 gene. Homozygous mutant mice (11beta-HSD2(-/-)) appear normal at birth, but approximately 50% show motor weakness and die within 48 hours. Both male and female survivors are fertile but exhibit hypokalemia, hypotonic polyuria, and apparent mineralocorticoid activity of corticosterone. Young adult 11beta-HSD2(-/-) mice are markedly hypertensive, with a mean arterial blood pressure of 146 +/- 2 mmHg, compared with 121 +/- 2 mmHg in wild-type controls and 114 +/- 4 mmHg in heterozygotes. The epithelium of the distal tubule of the nephron shows striking hypertrophy and hyperplasia. These histological changes do not readily reverse with mineralocorticoid receptor antagonism in adulthood. Thus, 11beta-HSD2(-/-) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. (+info)
Circadian changes in serum corticosterone levels affect hearing in mice exposed to noise. - Semantic Scholar
STRESS-INDUCED SENSITIZATION TO AMPHETAMINE AND MORPHINE PSYCHOMOTOR EFFECTS DEPEND ON STRESS-INDUCED CORTICOSTERONE SECRETION ...
Effect of corticosterone on noradrenergic nuclei in the pons-medulla and [3H]NA release from terminals in hippocampal slices
Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine - Zuloaga - 2014 - Journal of...
Frontiers | Differential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult...
Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve - Institutional Repository...
THE EFFECT of CORTICOSTERONE in RATS SUBMITTED TO the ELEVATED PLUS-MAZE and TO PENTYLENETETRAZOL-INDUCED CONVULSIONS
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Inhibitory effects of corticosterone on cell proliferation and stero- by E Saito, M Mukai et al.
Stress And Aggression Reinforce Each Other - ScienceAGoGo
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Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats. - PubMed - NCBI
Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring
Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels<...
Physiological responses of 3 chicken breeds to acute heat stress.
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Universiti Putra Malaysia Institutional Repository
Separation of pair housed roosters is associated with transient increased fecal corticosterone excretion
SAT0015 The negative effects of glucocorticoids on bone are primarily mediated by genes involved in osteoblast differentiation...
Bing ZHANG, Ph.D.
Science : Why stressful lives begin before birth | New Scientist
Manual versus automated blood sampling - Danish National Research Database-Den Danske Forskningsdatabase
Changes in Vascular Smooth Muscle Sensitivity to Vasoconstrictor Agents induced by Corticosteroids, Adrenalectomy and Differing...
Impaired development of broiler chickens by stress mimicked by corticosterone exposure.
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Modulation by Leptin, Insulin and Corticosterone of Oleoyl-estrone Synthesis in Cultured 3T3 L1 Cells | Bioscience Reports |...
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The Effects of Excess Corticosterone on LKB1 and AMPK Signaling in Ske by Gary N. Nakken
June | 2017 | Thrombin Inhibitors | Page 2
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REM sleeps unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice |...
Geographic variation in corticosterone response to chronic predator stress in tadpoles
Determination of corticosterone in rat and mouse plasma by gas chromatography-selected ion monitoring mass spectrometry<...
DGIST Scholar: Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life...
Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity-MedSci.cn
Fatty liver and plasma corticosterone levels in chronically alcohol- and pair-fed rats | Biochemical Society Transactions
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Abnormal Recovery from Acute Stress in Huntingtons Disease Mice
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Corticosterone ELISA Kit - (KA3385) - Products - Abnova
Physiological, morphological and behavioural effects of selecting zebra finches for divergent levels of corticosterone |...
Plasma levels of corticosterone in methylandrostenediol-salt-induced hypertension. - Semantic Scholar
Gentaur Molecular :Assaypro \ Corticosterone 21 Acetate antibody Species None Format IgG Host Rabbit Polyclonal antibody \...
Corticosterone (human) AlphaLISA Detection Kit, 500 Assay Points | PerkinElmer
Corticosterone Chemiluminescent CLIA kit - As One International, Inc.: K3014-C | Labscoop.com
Derics MindBlog: Even brief stress can zap your brain...
Pruett, Stephen B.
Corticoadrenal and behavioral response to open field in pairs of male rats either familiar or non-familiar to each other |...
Corticosterone - Metabolism - Diagnostics
Health Effects of Vitamins: Vitamin E and Anxiety
Prolonged increase of corticosterone secretion by chronic social stress does not necessarily impair immune functions
Diurnal variations in lipopolysaccharide-induced sleep, sickness behavior and changes in corticosterone levels in the rat<...
The CNS site of glucocorticoid negative feedback during LPS- and psychological stress-induced fevers<...
Applicability of Commercially Available ELISA Kits for the Quantification of Faecal Immunoreactive Corticosterone Metabolites...
Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons<...
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Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons
Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light. - Physiology, Anatomy and Genetics
Diurnal variation in corticosterone release among wild tropical forest birds | Frontiers in Zoology | Full Text
Membrane Receptors for Corticosterone: A Mechanism for Rapid Behavioral Responses in an Amphibian<...
Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of...
Repeated stress suppresses interferon-γ production by murine intestinal intraepithelial lymphocytes<...
Inhibition of adrenal steroidogenesis and heat shock protein 70 induction in neonatally feed restricted broiler chickens under...
Stress hormone dynamics: an adaptation to migration?
The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks<...
Corticosterone, prolactin and egg neglect behavior in relation to mercury and legacy POPs in a long-lived Antarctic bird
Effects of Probiotic on Immune Response and Intestine Morphology of Broiler Chicks Exposed to Stress Induced by Corticosterone
Stress, age, and cancer | Science Signaling
Search Results | Biochemical Journal | Portland Press
Limiting stress activation of the adrenergic and pituitary-adrenal systems by alpha-tocopherol
Withdrawal of salt supplementation from adrenalectomized Wistar rats distinguishes between those animals with, and those...
Publication : USDA ARS
Efectos a largo plazo de una sola exposición al estrés: relación con la adaptación al estrés crónico y factores implicados
Warning! Nearby construction can profoundly affect your experiments<...
Fetal programming of disease risk to next generation depends on paren... ( Overexposure to stress hormones in t...)
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Current Research and Problems of the Coronary Circulation | Circulation
Harry Harlow
... an increase in corticosterone secretion; and suppressed tissue ODC responsivity to administered growth hormone. Additionally, ... "Postnatal Touch Stimulation Acutely Alters Corticosterone Levels and Glucocorticoid Receptor Gene Expression in the Neonatal ...
5α-Dihydrocorticosterone
It is biosynthesized from corticosterone by the enzyme 5α-reductase. DHC has central depressant effects and impairs long-term ... 125-. ISBN 978-4-431-29567-9. Dubrovsky, B.; Williams, D.; Kraulis, I. (1985). "Effects of corticosterone and 5?- ...
DEFA4
HNP4 inhibits corticotropin-stimulated corticosterone production. ENSG00000285318 GRCh38: Ensembl release 89: ENSG00000164821, ...
Broda Otto Barnes
In 1938, Fleischmann and Kann determined that in addition to estrogen, a specific adrenal hormone, corticosterone, could cause ... See footnote 1 at Fleischmann, W.; Kann, S. (1938). "The Bitterling Ovipositor Reaction to Corticosterone". Science. 87 (2257 ... though it did open the door to an investigation of why corticosterone is significant in urine. Barnes, Broda Otto (1976). ...
18-Hydroxycorticosterone
It is a derivative of corticosterone. 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the ...
Common raven
The hormone known as corticosterone is activated by the hypothalamic-pituitary-adrenal axis. Corticosterone is activated when ... Cockrem, J. F. (2007). "Stress, corticosterone responses and avian personalities". Journal of Ornithology. 148: 169-178. doi: ...
Psychic numbing
... corticosterone and body-brain integration". Brain Research. 1476: 1-15. doi:10.1016/j.brainres.2011.12.049. PMID 22285436. "Why ...
Deoxycortisol
... corticosterone; 11β,21-dihydroxyprogesterone) 21-Deoxycortisol (11β,17α-dihydroxyprogesterone) Cortisol (hydrocortisone) ...
Aminoglutethimide
Aldosterone synthase (18-hydroxylase; CYP11B2). Prevents the conversion of corticosterone into aldosterone. As such, AG is an ... 11β-Hydroxylase (CYP11B1). Prevents the conversion of 11-deoxycorticosterone and 11-deoxycortisol into corticosterone and ...
Cortisol
Corticosterone is comparable to cortisol in this case. For potassium to move out of the cell, cortisol moves an equal number of ... However, in cattle, corticosterone levels may approach or exceed cortisol levels.). The medulla of the adrenal gland lies under ... Rapid administration of corticosterone (the endogenous type I and type II receptor agonist) or RU28362 (a specific type II ... unlike corticosterone, upon which potassium has no effect. Potassium loading also increases ACTH and cortisol in humans. This ...
SLC22A3
Ki values for decynium-22 and corticosterone inhibition of OCT3 transport are respectively 10 and 100 times lower than Ki ... Transport is also inhibited by the chemical decynium-22 and physiological concentrations of corticosterone and cortisol. ... Gründemann D, Schechinger B, Rappold GA, Schömig E (1999). "Molecular identification of the corticosterone-sensitive ... a corticosterone-sensitive monoamine transporter, in the rat brain". J Comp Neurol. 512 (4): 529-555. doi:10.1002/cne.21921. ...
ACTH stimulation test
"Vasoactive intestinal peptide stimulates adrenal aldosterone and corticosterone secretion". Endocrinology. 122 (5): 2090-2097. ...
Pine siskin
51: 2-3. Buttemer, WA; Astheimer, LB; Wingfield, JC (1991). "The Effect of Corticosterone on Standard Metabolic Rates of Small ... Astheimer, LB; Buttemer, WA; Wingfield, JC (1992). "Interactions of corticosterone with feeding, activity and metabolism in ... "Corticosterone Feeding Behavior and Food Deprivation in Passerine Birds". American Zoologist. 29 (4): 1-195A. doi:10.1093/icb/ ...
Familial hyperaldosteronism
This enzyme helps produce hormones called cortisol and corticosterone. The CYP11B2 gene provides instructions for making ...
XyMTeX
The following code produces the image for corticosterone below. \documentclass{letter} \usepackage{epic,carom} \pagestyle{empty ...
Agouti-related peptide
The protein blocks α-MSH-induced secretion of corticosterone. Orthologs of AgRP, ASIP, MCIR, and MC4R have been found in ...
Begging in animals
Corticosterone implanted chicks beg more frequently than non-implanted chicks. When there is a shortage of food, corticosterone ... Corticosterone increases begging effort and food provisioning rates by parents. ... begging indicating that juvenile hormone in insects could have a similar function to that of testosterone and corticosterone in ... by which juvenile hormone affects offspring growth in insects differ from those by which testosterone and corticosterone affect ...
Hummingbird
The circulating hormone, corticosterone, is one signal that arouses a hummingbird from torpor. Use and duration of torpor vary ... Hiebert, S. M.; Salvante, K. G.; Ramenofsky, M; Wingfield, J. C. (2000). "Corticosterone and nocturnal torpor in the rufous ...
Sex allocation
Higher corticosterone levels in breeding female Japanese quails were associated with female-biased sex ratios at laying. In ... Pike, TW; Petrie, M (2006). "Experimental evidence that corticosterone affects offspring sex ratios in quail". Proceedings of ...
Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency
Although production of cortisol is too inefficient to normalize ACTH, the 50-100-fold elevations of corticosterone have enough ... Consequently, levels of DOC, corticosterone, and 18-hydroxycorticosterone are elevated. Although these precursors of ...
Steroid 11β-hydroxylase
... corticosterone to 18-hydroxycorticosterone, cortisol to 18-hydroxycortisol. Besides that, 11β-hydroxylase may be involved in ... 11-deoxycorticosterone to corticosterone; medium activity: progesterone to 11β-hydroxyprogesterone, testosterone to 11β- ... 11-Deoxycortisol Cortisol 11-Deoxycorticosterone Corticosterone As a mitochondrial P450 system, P450c11 is dependent on two ... has strong catalytic activity during conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone, ...
Feather-plucking
In addition, parrots that feather-pluck have been found to have higher levels of corticosterone, a hormone secreted by many ... Owen, D.J; Lane, J.M. (2006). "High levels of corticosterone in feather-plucking parrots (Psittacus erithacus)". Veterinary ...
Corticosteroid
5), corticosterone (C. 21H. 30O. 4), cortisone (C. 21H. 28O. 5) and aldosterone (C. 21H. 28O. 5). (Note that aldosterone and ... Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is mediated either by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they ...
Sex hormone-binding globulin
Corticosterone. 0.18. 2.2. 12. 3.39. 0.09. 77.5. 19.0. 7.0. 3.28. 0.22. 78.1. 18.4 ...
Aldosterone
... and corticosterone share the first part of their biosynthetic pathways. The last parts are mediated either by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they ...
Glucocorticoid remediable aldosteronism
Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is either mediated by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). Aldosterone synthesis is stimulated by ...
Staci Bilbo
2008) Stressor-specific alterations in corticosterone and immune responses in mice. Brain, behavior, and immunity 22 (1), 105- ...
Animal welfare science
Bortolotti G.R.; Marchant T.A.; Blas J.; German T. (2008). "Corticosterone in feathers is a long-term, integrated measure of ... Royo F.; Mayo S.; Carlsson H.E.; Hau J. (2008). "Egg corticosterone: A noninvasive measure of stress in egg-laying birds". ... heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ...
Corticosterone methyloxidase deficiency: MedlinePlus Genetics
Corticosterone methyloxidase deficiency, also known as aldosterone synthase deficiency, is a disorder characterized by ... Genetic Testing Registry: Corticosterone methyloxidase type 1 deficiency *Genetic Testing Registry: Corticosterone ... the conversion of 11-deoxycorticosterone to corticosterone, the conversion of corticosterone to 18-hydroxycorticosterone, and ... Severe cases of corticosterone methyloxidase deficiency can result in seizures and coma and can be life-threatening. However, ...
Corticosterone - Wikipedia
Corticosterone both inhibits protein synthesis and degrades proteins. Birds with increased levels of corticosterone will have ... Corticosterone has further developmental effects on birds. Increased levels of corticosterone in chicks leads to increased ... corticosterone can either facilitate or interrupt conditioned fear. Not only does corticosterone have effects on emotional ... Corticosterone inhibits feather growth: Potential mechanism explaining seasonal down regulation of corticosterone during molt. ...
Corticosterone | Definition of Corticosterone at Dictionary.com
Corticosterone 18-monooxygenase - Wikipedia
Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. This enzyme participates in ... In enzymology, a corticosterone 18-monooxygenase (EC 1.14.15.5) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating ... H2O The 3 substrates of this enzyme are corticosterone, reduced adrenal ferredoxin, and O2, whereas its 3 products are 18- ...
NIOSHTIC-2 Publications Search - 20045491 - Corticosterone enhances chlorpyrifos-induced neuroinflammation.
Corticosterone after acute stress prevents the delayed effects on the amygdala | Neuropsychopharmacology
However, when stress was followed 24 h later by corticosterone in the drinking water, the surge in corticosterone was prevented ... We observed that post-stress corticosterone, given 1 day after acute stress in drinking water, reversed enhanced anxiety-like ... Together, these observations suggest that corticosterone, delivered through drinking water even 24 h after acute stress, is ... Strikingly, although the immobilization-induced surge in corticosterone by itself has delayed detrimental effects on amygdalar ...
Corticosterone
... Antiserum for 3H Assay (Rabbit), for 10,000 Tubes Corticosterone Antiserum for use in 3H Assay ... Corticosterone Double Antibody RIA Kit The kit is ready to use and includes the following components: Antiserum, 6 standards, ... Corticosterone ELISA Kit for Rats The kit is ready to use and includes the following components: Microtiter Plate, 6 ... Corticosterone Antiserum for 125I Assay (Rabbit), for 1000 Tubes Antibody is purified from rabbit and is sufficient for 1000 ...
Corticosterone - Substance Information - ECHA
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
Corticosterone - Metabolism - Diagnostics
The Corticosterone Double Antibody RIA Kit is intended for the measurement of corticosterone in a sample. It is specifically ... The Corticosterone ELISA Kit for Rats and Mice is a competitive immunoassay for the quantitative measurement of corticosterone ... Corticosterone antibody is purified from rabbit and is sufficient for 1000 tests. ...
Corticosterone >= 98.5 % HPLC | 50-22-6 | Sigma...
Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune ... Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune ... Corticosterone ≥98.5% (HPLC) Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21- ... Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It ...
vogelwarte.ch - Role of Corticosterone during migration
We measured plasma corticosterone levels in actively flying migratory birds: in red knots, Calidris canutus, flying up to 10 h ... Role of Corticosterone during migration Long-distance migration requires many physiological and behavioural adaptations such as ... We investigated whether corticosterone, the most prevalent glucocorticoid in birds, is involved in the regulation of bird ... A strong increase in corticosterone when fat reserves are near exhaustion triggers an increase in the catabolism of protein and ...
Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent. - PubMed - NCBI
The plasma corticosterone (CORT) level was measured in morphine and saline control animals 1 day after the last injection of a ... Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent.. Geoffroy H1,2,3, Canestrelli ... No more alteration in stubby spines in the shell was detected in morphine-treated rats with a depletion of corticosterone, ... Since morphine-treated rats also presented an elevation of corticosterone level in plasma, we explored whether spine ...
Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. - PubMed -...
Stress-induced corticosterone levels were also augmented in dyn(−/−) mice (d).. *p,0.05; **p,0.01; ***p,0.001 vs respective ... decrease in corticosterone serum levels in prodynorphin knockout mice. Although stress-induced increases in corticosterone ... Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.. Wittmann W1, ... No differences between the genotypes were observed in stress-induced hyperthermia (c). Basal corticosterone serum levels were ...
Research Sheds Light on Why Shuyusan can Treat Corticosterone-Induced Impairment
Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons
Neither dose of corticosterone affected the length of basal dendrites or spine density. Corticosterone was ineffective in ... Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. Journal. Hippocampus. Volume , Issue number ... In organotypic cultures (prepared from P5 rats) that were 14-21 days cultured in vitro, two doses of corticosterone (30 and 100 ... Exposing organotypic slices to 30 nM corticosterone reduced apical length in a more delayed manner: only neurons examined more ...
corticosterone Archives - Neuroscience News
Acupuncture Stimulation Alleviates Corticosterone-Induced Impairments of Spatial Memory and Cholinergic Neurons in Rats
Corticosterone, endogenous steroid hormone (CAS 50-22-6) (ab143597) | Abcam
REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice |...
Corticosterone regulation, anhedonia, and despair behavior.. Some transcripts in the cortical predictor set for corticosterone ... changes in corticosterone regulation, and anhedonia are interrelated. Alteration in corticosterone regulation and REMS have ... S3 A-D and S5). Degradation of coat state occurred from day 7, while differences in body weight, impairment of corticosterone ... REM sleeps unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice. ...
Corticosterone in territorial male Swainson's Thrushes varies in relation to forest age but not vegetation cover | SpringerLink
For baseline corticosterone, the top model included stand age with limited support for models that included vegetation cover. ... Mean baseline corticosterone for territorial male thrushes sampled in mature stands was 78.2 % higher than territorial males ... For handling-induced corticosterone, there was limited separation among candidate models, and only one model, containing stand ... Corticosterone in territorial male Swainsons Thrushes varies in relation to forest age but not vegetation cover. ...
Cortisol:corticosterone ratio | definition of cortisol:corticosterone ratio by Medical dictionary
What is cortisol:corticosterone ratio? Meaning of cortisol:corticosterone ratio medical term. What does cortisol:corticosterone ... corticosterone ratio in the Medical Dictionary? cortisol:corticosterone ratio explanation free. ... redirected from cortisol:corticosterone ratio). Also found in: Dictionary, Thesaurus, Encyclopedia. cortisol. [kor´tĭ-sol] a ... cortisol:corticosterone ratio. the ratio between the two hormones is different between species and even between individual ...
Impaired development of broiler chickens by stress mimicked by corticosterone exposure.
The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus ... Corticosterone / pharmacology*. Dietary Fats / administration & dosage*. Female. Insulin / blood. Male. Muscle, Skeletal / drug ... The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus ... Corticosterone treatment resulted in enhanced energy expenditure. The results indicate that the development of breast muscle ...
Enduring good memories of infant trauma: Rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone...
1991) Effects of corticosterone on response consolidation and retrieval in the forced swim test. Behav Neurosci 105(6):798-803 ... 1998) Serotonin modulation of sensory inputs to the lateral amygdala: Dependency on corticosterone. J Neurosci 18(22):9529-9538 ... 2010) Transitions in sensitive period attachment learning in infancy: The role of corticosterone. Neurosci Biobehav Rev 34(6): ... Trunk-blood samples were collected 30-min post FST, and plasma was used to analyze CORT levels (Rat Corticosterone Coat-A-Count ...
NIOSHTIC-2 Publications Search - 20025056 - Supraphysiological levels of the stress hormone corticosterone attenuate blood...
... and the ability of high levels of corticosterone to mo ... Male mice were implanted with a corticosterone pellet (192 mg/ ... Corticosterone pretreatment attenuated the kainate-induced influx of IgG at all time points. Immunohistochemical localization ... Kainate-induced seizures were scored at Stage 1 (Racine scale), and corticosterone pretreatment did not alter seizure activity ... Supraphysiological levels of the stress hormone corticosterone attenuate blood-brain barrier disruption and microglial ...
Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro | Science
Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro Message Subject. (Your Name) has forwarded a page ... This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent ...
Investigating the relationship between corticosterone and glucose in a reptile | Journal of Experimental Biology
2018). Corticosterone levels reflect variation in metabolic rate, independent of stress. Sci. Rep. 8, 13020. doi:10.1038/ ... 2001). Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird. Am. J. Physiol ... Regressions of corticosterone (CORT) and glucose following stress in wandering gartersnakes (Thamnophis elegans). (A) Baseline ... 2014). Temperature has species-specific effects on corticosterone in alligator lizards. Gen. Comp. Endocrinol. 206, 184-192. ...
Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner.
It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to ... Corticosterone / metabolism*, pharmacology. Fluorescent Antibody Technique. Hyperalgesia / metabolism. Intestinal Mucosa / drug ... It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to CPS ...
corticosterone •
Corticosterone (human) AlphaLISA Detection Kit, 500 Assay Points | PerkinElmer
Detect and quantitate human corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous ... Biotinylated corticosterone-BSA complex and free corticosterone (in standards or in samples) compete for binding to anti- ... When corticosterone-BSA binds to anti-corticosterone AlphaLISA acceptor beads, the beads come into close proximity. The ... The AlphaLISA® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, ...
CORTRatsSecretionHormoneIncreasing corticosterone levelsMiceEffect of corticosteroneSuggest that corticosteronePlasmaAdrenal cortexEndogenous corticosteroneConcentrationsBehaviorELISAHigh levels of corticosteroneLower corticosterone levelsSerum corticosterone levelsHigher corticosterone levelsChronic Corticosterone TreatmentBaselineRise in corticosteroneChanges in corticosteroneExposure to corticosteroneElevation of corticosteroneMetabolism of corticosteroneDetermination of corticosteroneTestosterone and corticosteroneAdministration of corticosteroneEnhancesMaternalHippocampalAcuteMetabolitesMediatesBirdsMethyl oxidaseYolk corticosteroneFecal corticosteroneAffect corticosteroneResponseSignificantlyBehavioralExogenousAntibodyAssaysMoleculeMalesMammalsEffects
CORT21
- Surprisingly, treatment with anti-inflammatory glucocorticoid, corticosterone (CORT), enhanced rather than suppressed DFP-induced neuroinflammation. (cdc.gov)
- Corticosterone (Cort) is a glucocorticoid hormone. (sigmaaldrich.com)
- The purpose of this study was to examine whether acupuncture improves spatial cognitive impairment induced by repeated corticosterone (CORT) administration in rats. (hindawi.com)
- The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus domesticus) fed with diets differing in lipid content were investigated. (biomedsearch.com)
- In adulthood, this trauma-linked odor rescues depressive-like behavior and amygdala dysfunction, reduces corticosterone (CORT) levels, and exerts repair-related changes at the molecular level. (pnas.org)
- The glucocorticoid hormone corticosterone (CORT) has classically been used in ecophysiological studies as a proxy for stress and energy mobilization, but rarely are CORT and the energy metabolites themselves concurrently measured. (biologists.org)
- It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to CPS. (biomedsearch.com)
- Corticosterone (CORT) is a member of corticosteroids and is also known as 17-deoxycortisol or 11β 21-dihydroprogesterone. (perkinelmer.com)
- Here, we exposed mice to the primary stress hormone corticosterone (CORT) during early adolescence (postnatal days 31-42), then tested behavioral flexibility in adulthood using an instrumental reversal learning task. (frontiersin.org)
- Evidence from recent studies has suggested that the avian stress-related hormone corticosterone (CORT) may play a role in immunocompetence and sexual selection. (biologists.org)
- We investigated latitudinal variation in corticosterone (CORT) response to chronic predator stress in Rana temporaria tadpoles along a 1500-km latitudinal cline in Sweden tadpoles, in a laboratory experiment. (diva-portal.org)
- Here we address this issue by examining the effects of chronic exposure to the stress hormone, corticosterone (CORT), in both adolescent and adult animals. (frontiersin.org)
- It has been well-established that compared to adults, adolescent animals exhibited different hypothalamo-pituitary-adrenal (HPA) axis functions in that they showed prolonged exposure to stress hormones, including adrenocorticotropic hormone (ACTH) and corticosterone (CORT), in response to both acute and chronic stress ( Romeo, 2013 ). (frontiersin.org)
- The massive meat production of broiler chickens make them continuously exposed to potential stressors that stimulate releasing of stress-related hormones like corticosterone (CORT) which is responsible for specific pathways in biological mechanisms and physiological activities. (sigmaaldrich.com)
- the first group received a daily intramuscular injection of 5 mg/kg BW corticosterone dissolved in 0.5 ml ethanol:saline solution (CORT group), while the second group received a daily intramuscular injection of 0.5 ml ethanol:saline only (CONT group). (sigmaaldrich.com)
- GA enhances the ability of corticosterone (Cort) to inhibit IL-1β- and forskolin- induced phospholipase (PLA2) activity. (nih.gov)
- I examined 1) the ontogeny of the corticosterone (CORT) response (both total and free hormone levels), 2) changes in corticosteroid receptor levels in brain with age, and 3) effects of acute and extended elevation of CORT on behavior and growth. (utexas.edu)
- Rats have rhythmic clock gene expression in the vmPFC that requires appropriate diurnal circulatory patterns of corticosterone (CORT), suggesting the presence of CORT-entrained intrinsic circadian clock function within the PFC. (eneuro.org)
- We examined the link between nest shelter, baseline corticosterone (CORT) levels and hatching success in common eiders (Somateria mollissima) incubating at nest sites with different levels of shelter. (gla.ac.uk)
- Corticosterone (CORT) is a glucocorticoid hormone that maintains energy balance and can modulate foraging behaviors in seabirds. (acap.aq)
- Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. (edu.au)
Rats27
- In studies on rats, the fluctuations of corticosterone concentration are shown to prevent stress' impairment of recognition memory in lower amounts. (wikipedia.org)
- Further, stress elevated serum corticosterone levels in rats that received vehicle in the drinking water. (nature.com)
- The Corticosterone ELISA Kit for Rats and Mice is a competitive immunoassay for the quantitative measurement of corticosterone in rat and mouse serum or plasma. (mpbio.com)
- Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro . (sigmaaldrich.com)
- Since morphine-treated rats also presented an elevation of corticosterone level in plasma, we explored whether spine alterations induced by morphine treatment in the nucleus accumbens could be affected by the depletion of the hormone. (nih.gov)
- No more alteration in stubby spines in the shell was detected in morphine-treated rats with a depletion of corticosterone, while a significant increase was observed in mushroom spines in the shell and stubby spines in the core. (nih.gov)
- In organotypic cultures (prepared from P5 rats) that were 14-21 days cultured in vitro, two doses of corticosterone (30 and 100 nM) were tested. (uva.nl)
- Corticosterone is produced under the control of ACTH and the production has a circadian rhythm with peak levels in the latter portion of the day in nocturnal animals like rats and is believed to play a decisive role in sleep-wake cycles. (biovendor.com)
- The effects of oleuropein, a phenolic compound in extra virgin olive oil, on protein metabolism were investigated by measuring testicular testosterone and plasma corticosterone levels in rats fed diets with different protein levels. (nih.gov)
- After 28 days of feeding, the testosterone level in the testis was significantly higher and the plasma corticosterone level was significantly lower in rats fed the 40% casein diet with oleuropein than in those fed the same diet without oleuropein. (nih.gov)
- These findings suggest that dietary supplementation with 0.1 g/100 g oleuropein alters the levels of hormones associated with protein anabolism by increasing urinary noradrenaline and testicular testosterone levels and decreasing plasma corticosterone level in rats fed a high-protein diet. (nih.gov)
- Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats. (nel.edu)
- The present work was aimed to evaluate whether swimming-exercise-induced stress leads to changes in the chronobiology parameters of the circadian rhythms of melatonin and corticosterone, and in the number and phagocytosis of peritoneal macrophages in 3-month-old male Wistar rats. (nel.edu)
- Basal plasma corticosterone was found to correlate positively with an active response to a novel environment and inescapable stress across all rats. (nih.gov)
- Elevation of plasma corticosterone levels and hippocampal glucocorticoid receptor translocation in rats: a potential mechanism for cognition impairment following chronic low-power-density microwave exposure. (emf-portal.org)
- It is not clear whether the disrupted corticosterone rhythm, resulting from high-fat feeding contributes to attenuated meal anticipation in high-fat fed rats. (salford.ac.uk)
- Our aim was to better characterize meal anticipation in rats fed a low- or high-fat diet, and to better understand the role of corticosterone in this process. (salford.ac.uk)
- We also used the glucocorticoid receptor antagonist, RU486, to dissect out the role of corticosterone in meal anticipation in rats given daily access to a meal with different fat content. (salford.ac.uk)
- Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. (sun.ac.za)
- Neither the spontaneous outflow nor the electrically stimulated release of [3H]NA from dorsal hippocampal slices of untreated rats was affected by exposure of the slices to corticosterone (10-7 M - 10-4 M) in the superfusion buffer. (sun.ac.za)
- Thus, chronic corticosterone treatment of rats altered the noradrenergic system of the pons-medulla, but did not change the α2-adrenoceptor-mediated modulation of NA release in the dorsal hippocampus, a major terminal area of the LC neurons. (sun.ac.za)
- Bipolar electrodes were implanted into the CA1 pyramidal cells of the dorsal hippocampus and the effect of electrical stimulation of these cells on corticosterone secretion was investigated in freely moving rats. (sun.ac.za)
- While cortisol and corticosterone are both produced in response to stress in humans, corticosterone is the predominant glucocorticoid produced in mice and rats. (neogen.com)
- While not always predictive of environmental stress in the wild, conditions such as starvation, rapid temperature change, or changes in daily routine can cause increased corticosterone levels in laboratory mice and rats. (neogen.com)
- Conditions such as starvation, rapid temperature change, or changes in daily routine can cause increased corticosterone levels in laboratory mice and rats. (medimabs.com)
- Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. (openrepository.com)
- To test this hypothesis, three 100 mg pellets of corticosterone were implanted subcutaneously in each of nine rats for two weeks. (byu.edu)
Secretion4
- Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms. (sciencemag.org)
- M. I. Cordero, J. J. Merino and C. Sandi, "Correlational Relationship between Shock Intensity and Corticosterone Secretion on the Establishment and Subsequent Expression of Contextual Fear Conditioning," Behavioral Neuroscience, Vol. 112, No. 4, 1998, pp. 885-891. (scirp.org)
- K , Bethea, C & Van De Kar, LD 1984, ' Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion ', Federation Proceedings , vol. 43, no. 3. (elsevier.com)
- Van De Kar, L. D. / Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion . (elsevier.com)
Hormone19
- Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. (wikipedia.org)
- During the last years the glucocorticoid hormone corticosterone was discussed as a candidate, which might orchestrate the energetic needs during migration. (vogelwarte.ch)
- These behavioral data are supported by an approximal 30% reduction in corticotropin-releasing hormone (CRH) mRNA expression in the hypothalamic paraventricular nucleus and central amygdala and an accompanying 30-40% decrease in corticosterone serum levels in prodynorphin knockout mice. (nih.gov)
- Sleep disturbances are common in stress-related disorders but the nature of these sleep disturbances and how they relate to changes in the stress hormone corticosterone and changes in gene expression remained unknown. (pnas.org)
- Supraphysiological levels of the stress hormone corticosterone attenuate blood-brain barrier disruption and microglial activation in hippocampus of C57BL/6J mice treated with kainic acid. (cdc.gov)
- Here, we examined whether the adrenal hormone, corticosterone, and brain corticotropin-releasing factor (CRF) were involved in such reinstatement. (jneurosci.org)
- Here, we determined whether the adrenal hormone corticosterone and brain corticotropin-releasing factor (CRF) are involved in the effects of stress and heroin-priming on relapse to heroin-seeking. (jneurosci.org)
- Corticosterone (C21H30O4, also called 11β,21-Dihydroxyproges-terone, Reichstein's Sub-stance H, or Kendall's Compound B) is, like cortisol and cortisone, a glucocorticoid hormone secreted from the cortex of adrenal gland. (biovendor.com)
- For the analysis of corticosterone concentrations in the faeces, we used ELISA tests with antibodies for this hormone. (wind-watch.org)
- We sampled 329 sage-grouse across four sites (two grazed and two ungrazed) encompassing 13 600 km 2 during the spring and late summer-early autumn of 2005 to evaluate whether demographic factors, breeding status, plasma protein levels, and residence in a cattle-grazed habitat were associated with the stress hormone corticosterone. (usgs.gov)
- Corticosterone, which is a stress hormone, increased with laying order within a clutch of eggs, probably because egg production requires a lot of energy. (spectroscopynow.com)
- They also found that the daytime effects of nicotine were greatest when levels of the stress hormone corticosterone were high. (ciggyfree.com)
- D'Alba, L. , Spencer, K.A. , Nager, R.G. and Monaghan, P. (2011) State dependent effects of elevated hormone: Nest site quality, corticosterone levels and reproductive performance in the common eider. (gla.ac.uk)
- Here we investigated effects of acute restraint stress and of the stress hormone corticosterone on CSD susceptibility as surrogate migraine marker, in a transgenic mouse model of familial hemiplegic migraine type 1 (FHM1), which displays increased glutamatergic cortical neurotransmission and increased propensity for CSD. (uu.nl)
- Corticosterone exposure during prenatal development as a result of maternal upregulation of circulating hormone levels has been shown to have effects on offspring development in mammals. (edu.au)
- We show that maternal corticosterone is transferred to egg yolk in an oviparous lizard (the mallee dragon, Ctenophorus fordi Storr), with significant variation among clutches in hormone levels. (edu.au)
- Male embryos exposed to relatively high levels of corticosterone were smaller on average than control males at hatching whereas females from hormone-treated eggs were larger on average than control females. (edu.au)
- Positive selection on body size at hatching for both sexes in this species further suggests that increased corticosterone in egg yolk may have sex-specific fitness consequences, with potential implications for sex allocation and the evolution of hormone-mediated maternal effects. (edu.au)
- Corticosterone , also known as 17-deoxycortisol and 11β,21-dihydroprogesterone , [1] is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands in rodents and other non-human animals. (worldheritage.org)
Increasing corticosterone levels1
- We pointed out the main factors increasing corticosterone levels in voles and features of the studied species that may determine the differences in their reaction including: the width of the ecological niche, spatial mobility, and predation pressure. (wind-watch.org)
Mice13
- Although stress-induced increases in corticosterone levels were attenuated in prodynorphin knockout mice, they were associated with minor increases in depression-like behavior in the tail suspension and forced swim tests. (nih.gov)
- Male mice were implanted with a corticosterone pellet (192 mg/kg/d) to mimic the sustained activation of the HPA axis associated with chronic stress, and allowed to recover for seven days. (cdc.gov)
- Interestingly, when administered a corticosterone treatment to mimic hypercorticism conditions, AdipoGR-KO mice exhibited an improved glucose tolerance and insulin sensitivity. (diabetesjournals.org)
- however, this WD-induced increase in plasma corticosterone was significantly attenuated in V1b⁻/⁻ mice. (nih.gov)
- H. Tomizawa, D. Matsuzawa, S. Matsuda, D. Ishii, C. Sutoh and E. Shimizu, "A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice," Journal of Behavioral and Brain Science , Vol. 3 No. 5, 2013, pp. 415-421. (scirp.org)
- Environmental enrichment during rearing alters corticosterone levels, thymocyte numbers, and aggression in female BALB/c mice: E.K. Hutchinson, et al. (cosmobio.co.jp)
- This work investigated the antioxidant and antidepressant-like effects of ethyl acetate extract from Eugenia catharinensis in mice treated with corticosterone (20 mg/Kg). (springer.com)
- Our results showed that the extract decreased the immobility time of mice in the forced swimming test and that the extract was able to reverse the effect caused by corticosterone. (springer.com)
- Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. (uzh.ch)
- We found that 20-min and 3-h restraint stress did not influence CSD susceptibility in mutant or wild-type mice, despite elevated levels of plasma corticosterone. (uu.nl)
- mg/kg corticosterone increased CSD frequency exclusively in mutant mice, while corticosterone plasma levels were similarly elevated in mutants and wild types. (uu.nl)
- Male and female mice were injected with MA (1 mg/kg) or saline for comparison of plasma corticosterone and analysis of the immediate early gene c-Fos in brain. (wiley.com)
- There was a prolonged elevation in corticosterone levels in female compared to male mice. (wiley.com)
Effect of corticosterone3
- There was no effect of corticosterone treatment on anxiety behavior in adults.Thus, I show that high maternal corticosterone is transferred to avian egg yolk and that it has lasting effects on offspring development and adult phenotype. (washington.edu)
- Vazquez-Palacios G, Retana-Marquez S, Bonilla-Jaime H, Velazquez-Moctezuma J. Further definition of the effect of corticosterone on the sleep-wake pattern in the male rat. (biovendor.com)
- The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone. (uu.nl)
Suggest that corticosterone2
- Together, these observations suggest that corticosterone, delivered through drinking water even 24 h after acute stress, is capable of reversing the delayed enhancing effects on BLA synaptic connectivity and anxiety-like behavior. (nature.com)
- The results suggest that corticosterone administration enhanced hepatic fatty acid synthesis and resulted in the redistribution of energy to abdominal store from peripheral tissues. (biomedsearch.com)
Plasma33
- We measured plasma corticosterone levels in actively flying migratory birds: in red knots, Calidris canutus , flying up to 10 h in a wind tunnel (collaboration with the University of Lund) and in free-ranging passerines caught out of migratory flight. (vogelwarte.ch)
- We compared the plasma corticosterone concentrations of birds with different migration strategies, namely long-distance, short-distance and irruptive migrants. (vogelwarte.ch)
- These findings suggest that it is relevant to maintain plasma corticosterone levels low during hippocampal development. (uva.nl)
- Corticosterone ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of corticosterone in serum and plasma and in extracted fecal samples. (abnova.com)
- Here I show that high plasma corticosterone in a laying bird corresponds to high corticosterone in the yolk of her eggs. (washington.edu)
- I then demonstrate that elevated yolk corticosterone has a range of effects on offspring development and adult phenotype.Female quail from selected for heightened plasma corticosterone response to capture and restraint lay eggs with higher yolk corticosterone than quail selected for a low plasma corticosterone response. (washington.edu)
- This difference in yolk corticosterone concentration is particularly interesting given that baseline corticosterone levels do not differ between the two lines.Experimentally elevating plasma corticosterone in laying quail increased corticosterone concentration in the yolk of their eggs. (washington.edu)
- Chicks that hatched from eggs laid by females implanted with corticosterone grew more slowly than controls, and showed higher plasma corticosterone response to capture and restraint as adults.To determine whether the effects of elevated maternal corticosterone were mediated by transfer of the steroid itself to yolk, yolk corticosterone concentration was manipulated directly. (washington.edu)
- Since most of corticosterone in blood is bound to a plasma protein called corticosterone-binding globulin (CBG), the determination of blood corticosterone with presently available commercial assay kits requires an initial extraction procedure. (biovendor.com)
- Comprehensive growth performance, immune function, plasma biochemistry, gene expressions and cell death morphology responses to a daily corticosterone injection course in broiler chickens. (sigmaaldrich.com)
- Radioimmunoassay was used to determine the plasma levels of melatonin and corticosterone. (nel.edu)
- The metabolism and distribution of intravenously administered tracer doses of corticosterone-1,2- 3 H are not affected by elevated plasma levels of endogenous corticosterone due to cold stress. (aspetjournals.org)
- Future work should also consider applying the LC-MS/MS technique when measuring corticosterone in eggs laid by females experiencing stressful conditions, and when assessing plasma-to-yolk transfer rates," said the researchers. (spectroscopynow.com)
- Plasma corticosterone levels were assessed using an ELISA. (wku.edu)
- Basal levels of plasma corticosterone were measured using radioimmunoassay. (nih.gov)
- Overall, SHR showed a more active response in the elevated plus-maze and forced swim test than WKY, regardless of treatment, and were also found to have higher basal plasma corticosterone compared to WKY. (nih.gov)
- Maternal separation increased basal levels of plasma corticosterone in SHR females only, possibly through adaptive mechanisms involved in maintaining their active response in behavioural tests. (nih.gov)
- Basal plasma corticosterone levels of SHR and WKY males (M) and females (F), maternally separated (MS) or non-maternally separated (nMS). (nih.gov)
- The IBL International Corticosterone (Human, Rat, Mouse) ELISA is an enzyme immunoassay for the quantitative measurement of Corticosterone in serum and plasma. (ibl-international.com)
- Microwave exposure increased levels of plasma corticosterone , glucocorticoid receptor nuclear translocation ( microwave exposure caused a decrease in the cytoplasmic signal and an increase in the nuclear signal compared to sham exposed control) and apoptosis in the hippocampus . (emf-portal.org)
- Thus, sex differences in MA-induced plasma corticosterone levels and activation of distinct brain regions and proteins involved in HPA axis regulation may contribute to sex differences in acute effects of MA on the brain. (wiley.com)
- Methamphetamine induces a prolonged plasma corticosterone response in females compared to males. (wiley.com)
- These findings indicate a sex difference in the neural regulation of methamphetamine-induced plasma corticosterone release. (wiley.com)
- Results of this study will be used in conjunction with plasma corticosterone assays to validate the use of leukocytes profiles for determining stress levels in pitvipers. (uark.edu)
- Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. (elsevier.com)
- Our results showed that exposure to chronic variable stress increased basal plasma corticosterone levels and that both, chronic restraint and variable stresses, promote higher corticosterone levels in response to a novel environment, but not to a challenge restraint stress, as compared to the control (non-stressed) group. (unesp.br)
- Most RIAs or EIAs require solvent extraction techniques to measure serum or plasma corticosterone levels, however extraction may be very difficult or impossible with mouse samples due to the large volumes of plasma or serum required for most extraction protocols. (being-bioreactive.com)
- Some kits allow the quantification of corticosterone from as little as 1 ul serum / plasma. (being-bioreactive.com)
- The principle of these kits is that serum or plasma samples are treated with an equal volume of a special Dissociation Reagent that liberates the corticosterone from any binding proteins. (being-bioreactive.com)
- The DetectX ® Corticosterone Enzyme Immunoassay kit measures corticosterone present in tissue culture, serum, plasma and fecal samples. (antibody-antibodies.com)
- Cockerels were exercised to observe the influence of physical activity on plasma corticosterone concentrations. (uark.edu)
- The plasma corticosterone levels as determined by radioimmunoassay showed extreme variations within collections. (uark.edu)
- The causes for the wide variation of plasma corticosterone levels in these birds remain unknown. (uark.edu)
Adrenal cortex4
- Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. (sigmaaldrich.com)
- Corticosterone is a glucocorticoid secreted by the adrenal cortex in response to stress. (neogen.com)
- However, in humans , corticosterone is the primary glucocorticoid that is produced primarily in the zona fasciculata of the adrenal cortex . (worldheritage.org)
- Corticosterone is produced in response to stimulation of the adrenal cortex by ACTH and is the precursor of aldosterone. (antibody-antibodies.com)
Endogenous corticosterone2
- Endogenous Corticosterone of a sample competes with a Corticosterone-horseradish peroxidase conjugate for binding to the coated antibody. (ibl-international.com)
- The heat-induced synthesis of HSP was depressed by caponization and depressed further in the capons fed metyrapone, which blocks the synthesis pathway of endogenous corticosterone in adrenal glands. (umm.ac.id)
Concentrations3
- During refuelling when birds are in a resorptive state slightly elevated corticosterone concentrations seem to support fuel deposition. (vogelwarte.ch)
- Over 25 days of testing, a U-shaped relationship emerged between the corticosterone concentrations and the timing of breeding. (spectroscopynow.com)
- Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. (elsevier.com)
Behavior9
- We observed that post-stress corticosterone, given 1 day after acute stress in drinking water, reversed enhanced anxiety-like behavior 10 days later. (nature.com)
- Fig. 1: Corticosterone in drinking water after stress prevents increase in anxiety-like behavior 10 days later. (nature.com)
- Male, but not female, chicks that hatched from eggs injected with corticosterone grew more slowly than controls, and female, but not male, offspring showed a decreased corticosterone response as adults.Finally, eggs were injected with corticosterone and chick performance in a maze, and adult expression of anxiety behavior were quantified to investigate the effects of elevated yolk corticosterone on cognitive ability and behavior. (washington.edu)
- We also found that the correlation between corticosterone levels and freezing behavior during extinction was disrupted in the pair-exposure situation. (scirp.org)
- The pair-exposure changed an association between corticosterone levels and freezing behavior during extinction. (scirp.org)
- S. E. File and L. A. Peet, "The Sensitivity of the Rat Corticosterone Response to Environmental Manipulations and to Chronic Chlordiazepoxide Treatment," Physiology & Behavior, Vol. 25, No. 5, 1980, pp. 753-758. (scirp.org)
- Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood: N. Lajud, et al. (cosmobio.co.jp)
- 2) the observed highest level of corticosterone in FPP parrot suggests a role of stress in this self-injuring stereotypic behavior. (peerj.com)
- Diurnal variations in lipopolysaccharide-induced sleep, sickness behavior and changes in corticosterone levels in the rat. (mpg.de)
ELISA2
- The IBL Corticosterone (Human, Rat, Mouse) ELISA Kit is a solid phase enzyme-linked immunosorbent assay (ELISA), based on the principle of competitive binding. (ibl-international.com)
- This is an ELISA (Enzyme-Linked ImmunoSorbent Assay) for the quantitative analysis of Corticosterone levels in biological fluid. (neogen.com)
High levels of corticosterone1
- We evaluated the consequences of kainate treatment on the blood-brain barrier and microglial activation, and the ability of high levels of corticosterone to modulate pathology. (cdc.gov)
Lower corticosterone levels2
- In contrast, breeding males showed much lower corticosterone levels during the breeding season than all other classes, and were the only class that showed an increase of corticosterone from the breeding to the non-breeding season. (uzh.ch)
- WT and HP parrots showed lower corticosterone levels than FPP parrots. (peerj.com)
Serum corticosterone levels2
- Fig. 4: Post-stress corticosterone treatment leads to a reduction in stress-induced increase in serum corticosterone levels. (nature.com)
- The mixture is then diluted 1:50 or greater with Assay Buffer and added directly to the well of the provided microtiter plate.Typical c57bl/6j mouse serum corticosterone levels fall at 0.08 ± 0.01 µM and therefore can be measured in this assay without extraction. (being-bioreactive.com)
Higher corticosterone levels1
- While the team's research could shed light on why people smoke and how nicotine affects them, Stitzel says more research is needed to determine the role that melatonin plays in altering the effects of nicotine, and whether the correlation between higher corticosterone levels and nicotine sensitivity is a coincidence. (ciggyfree.com)
Chronic Corticosterone Treatment1
- Chronic corticosterone treatment (14 days) did not alter the α2-adrenoceptor-mediated modulation of [3H]NA release from dorsal hippocampal slices. (sun.ac.za)
Baseline6
- During migratory flight, when birds are in a fasting state, slightly elevated baseline levels of corticosterone promote the mobilisation of the energy stores. (vogelwarte.ch)
- For baseline corticosterone, the top model included stand age with limited support for models that included vegetation cover. (springer.com)
- Mean baseline corticosterone for territorial male thrushes sampled in mature stands was 78.2 % higher than territorial males sampled in early seral stands. (springer.com)
- Despite previous research that has shown hardwood cover is an important component of breeding habitat quality for thrushes, our investigation found limited evidence that vegetation cover was associated with either baseline or handling-induced corticosterone levels. (springer.com)
- Given that early seral and mature conifer forests are characterized by markedly different habitat features, we hypothesize that the observed differences in baseline corticosterone represent either reduced fitness of male thrushes in mature stands or an adaptive adjustment of glucocorticoid levels to match local environmental conditions that equalize fitness across stands of different ages. (springer.com)
- All groups showed a spike in corticosterone levels immediately following exercise which returned to baseline at one-hour post. (wku.edu)
Rise in corticosterone2
- Decreased IgM production along with an early rise in corticosterone followed by a subsequent decrease was noted for each RCI situation. (hindawi.com)
- These measures were significantly attenuated in response to a high-fat diet, and animals on this diet exhibited a postanticipatory rise in corticosterone. (salford.ac.uk)
Changes in corticosterone1
- Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex. (semanticscholar.org)
Exposure to corticosterone1
- Exposing organotypic slices to 30 nM corticosterone reduced apical length in a more delayed manner: only neurons examined more than 2 hours after exposure to corticosterone showed atrophy of the apical dendritic tree. (uva.nl)
Elevation of corticosterone1
- Dietary restriction causes chronic elevation of corticosterone and enhances stress response in red-legged kittiwake chicks. (biovendor.com)
Metabolism of corticosterone1
- The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase. (sigmaaldrich.com)
Determination of corticosterone2
- The AlphaLISA ® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). (perkinelmer.com)
- On the other hand, the present assay kit for corticosterone newly developed by our laboratory provides a tool for direct determination of corticosterone in blood by simple dilution of blood samples with the diluent included in the kit. (biovendor.com)
Testosterone and corticosterone3
- Large comb (LC) broiler cockerels, with high levels of testosterone and corticosterone, survived acute heat stress while small comb (SC) cockerels, with low levels of testosterone and corticosterone were more susceptible to heat stress and suffered higher mortality rates. (umm.ac.id)
- To determine whether steroid hormones, testosterone and corticosterone, influence the expression of HSP in chickens, exogenous testosterone and corticosterone were implanted in LC capons and metyrapone-fed LC capons, respectively. (umm.ac.id)
- The results suggested that the steroid hormones, testosterone and corticosterone, are involved in the expression of HSP, which are associated with acquired and maintained thermoresistance in domestic chickens. (umm.ac.id)
Administration of corticosterone1
- Although corticosterone levels rise also during acute stress, the latter likely triggers a spatiotemporally more complex biological response with multiple positive and negative modulators which may not be adequately modeled by exogenous administration of corticosterone alone. (uu.nl)
Enhances2
Maternal1
- Future studies are needed to understand the role of maternal corticosterone in yolk within an ecological context. (washington.edu)
Hippocampal3
- These results suggest that high physiological levels of corticosterone, via activation of the glucocorticoid receptor, can, during the course of only a few hours, reduce the dendritic complexity of CA1 pyramidal neurons in young, developing hippocampal tissue. (uva.nl)
- Staining with Isolectin B4 revealed numerous microglial cells throughout the hippocampal parenchyma at 12 hours post treatment, and an attenuation in the quantity of microglia by corticosterone pretreatment. (cdc.gov)
- To address the question whether corticosterone mediates the stress-induced up-regulation of reelin gene expression, we used age-matched hippocampal slice cultures derived from male and female mouse pups. (ovid.com)
Acute1
- We tested the effects of adrenalectomy, chronic exposure to the corticosterone synthesis inhibitor metyrapone (100 mg/kg, s.c., twice daily), acute exposure to metyrapone, acute intracerebroventricular injections of CRF (0.3 and 1.0 μg), and intracerebroventricular injections of the CRF antagonist α-helical CRF (3 and 10 μg). (jneurosci.org)
Metabolites2
- Immunoreactive corticosterone and corticosterone metabolites (ICCM) were quantified in excreta of permanently single housed (n=10) and permanently pair housed (n=20) roosters. (diva-portal.org)
- Corticosterone was measured in feces as immunoreactive corticosterone metabolites (ICM). (usgs.gov)
Mediates2
- Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. (abcam.com)
- Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner. (biomedsearch.com)
Birds11
- A sizable amount of research has been done on the effects of corticosterone in birds. (wikipedia.org)
- Birds with increased levels of corticosterone will have slower feather growth during their molting period and an extended period of poor flight. (wikipedia.org)
- As a result, many birds have reduced levels of corticosterone when they moult so as to prevent the degradation of their new feathers. (wikipedia.org)
- Corticosterone has further developmental effects on birds. (wikipedia.org)
- In the short term this leads to higher chance of obtaining food, but in the long term, increased corticosterone in early life compromises the birds cognitive functioning (problem solving, association of visual cue with food, etc. (wikipedia.org)
- We investigated whether corticosterone, the most prevalent glucocorticoid in birds, is involved in the regulation of bird migration. (vogelwarte.ch)
- These hormones (primarily cortisol in primates, and corticosterone in birds, reptiles and rodents) are released in response to stressful environmental events, and are crucial in initiating the `flight or fight' response as well as a range of essential physiological and behavioural reactions to stress ( Nelson, 1995 ). (biologists.org)
- Overall levels of calbindin were higher in the HP of corticosterone-treated birds, due almost entirely to elevated calbindin expression in the dorsolateral subdivision of the HP only. (ovid.com)
- Corticosterone greatly impacted mortality: half of the corticosterone-implanted cardinals died between five - 11 days post-inoculation whereas only one of nine empty-implanted (control) birds died. (biomedcentral.com)
- No differences were found in viral titer between corticosterone- and empty-implanted birds. (biomedcentral.com)
- In sum, this study indicates that elevated corticosterone could affect the survival of WNV-infected wild birds, suggesting that populations may be disproportionately at-risk to disease in stressful environments. (biomedcentral.com)
Methyl oxidase1
- Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. (wikipedia.org)
Yolk corticosterone1
- Experimental elevation of yolk corticosterone did not affect hatching success, incubation period or offspring sex ratio. (edu.au)
Fecal corticosterone2
- The purpose of the present study was to compare the fecal corticosterone levels of companion African grey parrots kept as wild-type parrots (WT), healthy pet parrots (HP) and feather picking pet parrots (FPP) during the breeding season and out of the breeding season. (peerj.com)
- A statistical trend between fecal corticosterone concentration in the different seasons for the WT parrots (P=0.085) was observed, but not for the other groups. (peerj.com)
Affect corticosterone1
- Studies show that the modification of certain chemical and brain processes that affect corticosterone levels can also impact stress effects on memory. (wikipedia.org)
Response7
- Corticosterone is also being studied in different fields such as impairment of long-term memory retrieval, chronic corticosterone elevation due to dietary restrictions and response to burn injuries etc. (biovendor.com)
- The common vole showed a distinct physiological response − the individuals living near the wind turbines had a higher level of corticosterone. (wind-watch.org)
- Corticosterone is thought to be the main glucocorticoid secreted in response to stressful exercise, while melatonin buffers the adverse immunological effects of stress. (nel.edu)
- These data confirm that melatonin and corticosterone act as modulators of the innate immune response, and that the circadian rhythm of the two hormones are altered in situations of stress. (nel.edu)
- Basal levels of corticosterone correlate with the behavioural response to early life trauma, and may therefore provide a useful marker for susceptibility to a certain behavioural temperament. (nih.gov)
- Using an important zoonotic pathogen, West Nile virus (WNV) and a competent host, the Northern Cardinal ( Cardinalis cardinalis ), we tested the effects of exogenous corticosterone on response to WNV infection. (biomedcentral.com)
- Studies involving corticosterone and levels of stress include impairment of long term memory retrieval, chronic corticosterone elevation due to dietary restrictions and in response to burn injuries. (antibody-antibodies.com)
Significantly3
- Stress significantly decreased the MESOR and amplitude of the melatonin rhythm, and significantly increased the MESOR of the corticosterone rhythm. (nel.edu)
- In the first two experiments corticosterone significantly decreased the noradrenaline (NA) and dopamine (DA) levels in the pons-medulla, an area which contains the A1-A7 noradrenergic cell groups, while the NA and DA levels in the dorsal hippocampus remained unchanged. (sun.ac.za)
- Quantitative determination of mRNA levels revealed that corticosterone treatment significantly up-regulated reelin mRNA expression in male, but not in female hippocampi. (ovid.com)
Behavioral1
- The purpose of the present study was to compare the effect of two different stress paradigms (chronic restraint or variable stress) on behavioral and corticosterone release to a subsequent exposure to stressors. (unesp.br)
Exogenous1
- The exogenous testosterone and to a lesser degree, corticosterone, stimulated the expression of HSP in heat-stressed capons. (umm.ac.id)
Antibody7
- The Corticosterone Double Antibody RIA Kit is intended for the measurement of corticosterone in a sample. (mpbio.com)
- Corticosterone antibody is purified from rabbit and is sufficient for 1000 tests. (mpbio.com)
- Biotinylated corticosterone-BSA complex and free corticosterone (in standards or in samples) compete for binding to anti-corticosterone antibody that is conjugated to AlphaLISA Acceptor beads. (perkinelmer.com)
- The microtiter wells are coated with a polyclonal antibody directed towards an antigenic site on the Corticosterone molecule. (ibl-international.com)
- This test kit operates based on competition between the enzyme conjugate and the Corticosterone in the sample for a limited number of binding sites on the antibody coated plate. (neogen.com)
- The binding reaction is initiated by the addition of a polyclonal antibody to corticosterone. (antibody-antibodies.com)
- RABBIT ANTI CORTICOSTERONE-POLYCLONAL ANTIBODY antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of RABBIT ANTI CORTICOSTERONE-POLYCLONAL ANTIBODY. (antibody-antibodies.com)
Assays2
- L.B.M. and A.L.L. were supported by National Science Foundation (grant #0920475) during writing and for corticosterone assays. (springer.com)
- Top) GMC were incubated for 48 h with combinations of IL-1β (5 nM), corticosterone (50 nM), and glycyrrhetinic acid (5 μM), and PLA2 assays were performed. (nih.gov)
Molecule1
- Corticosterone is the precursor molecule to the mineralocorticoid aldosterone, one of the major homeostatic modulators of sodium and potassium levels in vivo. (wikipedia.org)
Males3
- The levels of corticosterone and testosterone declined by approximately 50% from the breeding to the non-breeding season in breeding females as well as non-breeding males and females. (uzh.ch)
- As a result, breeding males had similar corticosterone levels as other social classes during the non-breeding season. (uzh.ch)
- The data thus suggest that males are not just more sensitive to the detrimental effects of corticosterone but rather that the sexes may have opposite responses to corticosterone during development. (edu.au)
Mammals1
- Corticosterone is a major indicator of stress in non-human mammals. (being-bioreactive.com)
Effects9
- To counter this, during extended periods of food shortage, chicks of some species may suppress corticosterone activity and thus reduce the negative effects elevated corticosterone induces. (wikipedia.org)
- Corticosterone has multiple effects on memory. (wikipedia.org)
- Not only does corticosterone have effects on emotional memories but memory recognition and consolidation as well. (wikipedia.org)
- With respect to recognition and long term memories, corticosterone has variable effects. (wikipedia.org)
- Strikingly, although the immobilization-induced surge in corticosterone by itself has delayed detrimental effects on amygdalar structure and function, there exists a window of opportunity even after stress to mitigate its impact with a second surge of exogenously administered corticosterone. (nature.com)
- The extract increased the catalase and superoxide dismutase activities and reversed the effects of corticosterone. (springer.com)
- The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. (sun.ac.za)
- DI-fusion Teratogenic effects of chronic treatment with corticosterone. (ac.be)
- Teratogenic effects of chronic treatment with corticosterone on tadpoles of Xenopus laevis. (ac.be)