Corticosterone. Medical search

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).

Excision of one or both adrenal glands. (From Dorland, 28th ed)

The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.

A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.

Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.

A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.

An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Stress wherein emotional factors predominate.

A serpin family member that binds to and transports GLUCOCORTICOIDS in the BLOOD.

Cytoplasmic proteins that specifically bind MINERALOCORTICOIDS and mediate their cellular effects. The receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of DNA.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.

Nucleus in the anterior part of the HYPOTHALAMUS.

Physical manipulation of animals and humans to induce a behavioral or other psychological reaction. In experimental psychology, the animal is handled to induce a stress situation or to study the effects of "gentling" or "mothering".

The observable response an animal makes to any situation.

A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

An anti-inflammatory 9-fluoro-glucocorticoid.

The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.

A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

A chlorinated anilide that is used as an herbicide.

Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.

Prolonged separation of the offspring from the mother.

The measurement of an organ in volume, mass, or heaviness.

A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.

Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.

Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.

A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.

The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.

An excessive number of individuals, human or animal, in relation to available space.

Histidine substituted in any position with one or more methyl groups.

A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.

Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione.

Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)

The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.

Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Elements of limited time intervals, contributing to particular results or situations.

Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.

Substances that reduce or suppress INFLAMMATION.

17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

The consumption of edible substances.

A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

The inner zone of the adrenal cortex. This zone produces the enzymes that convert PREGNENOLONE, a 21-carbon steroid, to 19-carbon steroids (DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE) via 17-ALPHA-HYDROXYPREGNENOLONE.

The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

The physical activity of a human or an animal as a behavioral phenomenon.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Flat keratinous structures found on the skin surface of birds. Feathers are made partly of a hollow shaft fringed with barbs. They constitute the plumage.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication.

Refers to animals in the period of time just after birth.

The family Passeridae comprised of small, mainly brown and grey seed-eating birds with conical bills.

Injections into the cerebral ventricles.

Any type of variation in the appearance of energy output of the sun. (NASA Thesaurus, 1994)

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.

Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

The capability of producing eggs (OVA) from which young are hatched outside the body. While mostly referring to nonmammalian species, this does include MAMMALS of the order MONOTREMATA.

The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.

Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.

A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.

Large herbivorous tropical American lizards.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Animal behavior associated with the nest; includes construction, effects of size and material; behavior of the adult during the nesting period and the effect of the nest on the behavior of the young.

Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)

One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.

The withholding of food in a structured experimental situation.

Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (1/3099)

In Balb/c mice with pulmonary tuberculosis, there is a switch from a protective Th1-dominated cytokine profile to a non-protective profile with a Th2 component. This switch occurs while the adrenals are undergoing marked hyperplasia. Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective. We investigated the effects of these hormones as therapeutic agents by administering them from day 60, when the switch to the non-protective cytokine profile was already well established. Given at this time (day 60), doses that were protective when given early (from day 0) were rapidly fatal. A physiological dose of the glucocorticoid corticosterone was also rapidly fatal. However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha. Therefore this combination of steroids has an emergent property that is quite unlike that of either type of steroid given alone. It may be possible to exploit the ant-inflammatory properties of glucocorticoids while preserving a Th1 bias, by combining glucocorticoids with DHEA or suitable metabolites. (+info)

Maternal adrenocortical hormones maintain the early development of pancreatic B cells in the fetal rat. (2/3099)

To investigate the effect of maternal adrenocortical hormones on the development of fetal pancreatic islet cells, pregnant rats were adrenalectomised on d 6 of gestation. On d 12-16 the growth patterns of fetal insulin-producing B cells, glucagon-producing A cells, and somatostatin-producing D cells were observed histometrically. Maternal adrenalectomy resulted in growth retardation of fetal B cells on d 12-15. Maternal corticosterone therapy prevented this retardation. Maternal adrenalectomy, however, did not affect the developmental patterns of A and D cells. By Western blotting and immunohistochemistry, glucocorticoid receptors were demonstrated to be present in the islet cells from d 12 to d 15. These results suggest that maternal adrenocortical hormones, glucocorticoids in particular, maintain the early development of fetal pancreatic B cells through their specific intracellular glucocorticoid receptor. (+info)

The Ca2+ channel blockade changes the behavioral and biochemical effects of immobilization stress. (3/3099)

We investigated how the effects of chronic immobilization stress in rats are modified by Ca2+ channel blockade preceding restraint sessions. The application of nifedipine (5 mg/kg) shortly before each of seven daily 2 h restraint sessions prevented the development of sensitized response to amphetamine as well as the stress-induced elevation of the densities of L-type Ca2+ channel in the hippocampus and significantly reduced the elevation of the densities of [3H]nitrendipine binding sites in the cortex and D1 dopamine receptors in the limbic forebrain. Neither stress, nor nifedipine affected the density of alpha 1-adrenoceptors and D1 receptors in the cerebral cortex nor D2 dopamine receptors in the striatum. A single restraint session caused an elevation of blood corticosterone level that remained unaffected by nifedipine pretreatment, but the reduction of this response during the eighth session was significantly less expressed in nifedipine-treated rats. We conclude that L-type calcium channel blockade prevents development of several stress-induced adaptive responses. (+info)

Relationships between environmental organochlorine contaminant residues, plasma corticosterone concentrations, and intermediary metabolic enzyme activities in Great Lakes herring gull embryos. (4/3099)

Experiments were conducted to survey and detect differences in plasma corticosterone concentrations and intermediary metabolic enzyme activities in herring gull (Larus argentatus) embryos environmentally exposed to organochlorine contaminants in ovo. Unincubated fertile herring gull eggs were collected from an Atlantic coast control site and various Great Lakes sites in 1997 and artificially incubated in the laboratory. Liver and/or kidney tissues from approximately half of the late-stage embryos were analyzed for the activities of various intermediary metabolic enzymes known to be regulated, at least in part, by corticosteroids. Basal plasma corticosterone concentrations were determined for the remaining embryos. Yolk sacs were collected from each embryo and a subset was analyzed for organochlorine contaminants. Regression analysis of individual yolk sac organochlorine residue concentrations, or 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQs), with individual basal plasma corticosterone concentrations indicated statistically significant inverse relationships for polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDDs/PCDFs), total polychlorinated biphenyls (PCBs), non-ortho PCBs, and TEQs. Similarly, inverse relationships were observed for the activities of two intermediary metabolic enzymes (phosphoenolpyruvate carboxykinase and malic enzyme) when regressed against PCDDs/PCDFs. Overall, these data suggest that current levels of organochlorine contamination may be affecting the hypothalamo-pituitary-adrenal axis and associated intermediary metabolic pathways in environmentally exposed herring gull embryos in the Great Lakes. (+info)

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. (5/3099)

We have examined neuroanatomical, biochemical and endocrine parameters and spatial learning in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) during ageing. Aged beta2(-/-) mutant mice showed region-specific alterations in cortical regions, including neocortical hypotrophy, loss of hippocampal pyramidal neurons, astro- and microgliosis and elevation of serum corticosterone levels. Whereas adult mutant and control animals performed well in the Morris maze, 22- to 24-month-old beta2(-/-) mice were significantly impaired in spatial learning. These data show that beta2 subunit-containing nAChRs can contribute to both neuronal survival and maintenance of cognitive performance during ageing. beta2(-/-) mice may thus serve as one possible animal model for some of the cognitive deficits and degenerative processes which take place during physiological ageing and in Alzheimer's disease, particularly those associated with dysfunction of the cholinergic system. (+info)

High-temperature effects on antibody response to viral antigen in mice. (6/3099)

To determine the effects of high-temperature exposure on antibody response to viral antigen in mice, male BALB/c mice were placed for 13 days in animal chambers at 23 degrees C, 32 degrees C, and 35.5 degrees C. Rectal temperature rose from 37 degrees C to 39 degrees C on day 1 in a 35.5 degrees C environment. The rectal temperature was kept constant throughout the exposure period. The IgG-antibody to Sendai virus (SV) antigen was inhibited to about 50% of the control value (23 degrees C). The serum corticosterone concentration indicating thermal stress increased steadily, peaking on day 1 and then gradually decreased and recovered to the normal level on day 13. Body weight decreased to about 72% of the controls on day 13. Thymus and spleen weight decreased to 31.7% and 61.5% respectively. At 32 degrees C, these effects were less than at 35.5 degrees C. Effects of high-temperature exposure at 35.5 degrees C appeared to noticeably decrease thymus and spleen weight. It is clear that IgG-antibody response to SV antigen is suppressed by high-temperature exposure. (+info)

Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. (7/3099)

Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6 (rrIL-6) on the induction of hypothalamic-pituitary-adrenal (HPA) activity, fever, social investigatory behavior, and immobility. After intracerebroventricular administration of rrIL-6 (50 or 100 ng/rat), rats demonstrated HPA and febrile responses. In contrast, rrIL-6 alone did not induce changes in social investigatory and locomotor behavior at doses of up to 400 ng/rat. Coadministration of rrIL-6 (100 ng/rat) and rrIL-1beta (40 ng/rat), which alone did not affect the behavioral responses, reduced social investigatory behavior and increased the duration of immobility. Compared with rhIL-6, intracerebroventricular administration of rrIL-6 (100 ng/rat) induced higher HPA responses and early-phase febrile responses. This is consistent with a higher potency of rrIL-6, compared with rhIL-6, in the murine B9 bioassay. We conclude that species-homologous rrIL-6 alone can act in the brain to induce HPA and febrile responses, whereas it only reduces social investigatory behavior and locomotor activity in the presence of IL-1beta. (+info)

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. (8/3099)

Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and hypertension. However, the disorder is usually incompletely corrected by suppression of cortisol, suggesting additional and irreversible changes, perhaps in the kidney. To examine this further, we produced mice with targeted disruption of the 11beta-HSD2 gene. Homozygous mutant mice (11beta-HSD2(-/-)) appear normal at birth, but approximately 50% show motor weakness and die within 48 hours. Both male and female survivors are fertile but exhibit hypokalemia, hypotonic polyuria, and apparent mineralocorticoid activity of corticosterone. Young adult 11beta-HSD2(-/-) mice are markedly hypertensive, with a mean arterial blood pressure of 146 +/- 2 mmHg, compared with 121 +/- 2 mmHg in wild-type controls and 114 +/- 4 mmHg in heterozygotes. The epithelium of the distal tubule of the nephron shows striking hypertrophy and hyperplasia. These histological changes do not readily reverse with mineralocorticoid receptor antagonism in adulthood. Thus, 11beta-HSD2(-/-) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. (+info)

... an increase in corticosterone secretion; and suppressed tissue ODC responsivity to administered growth hormone. Additionally, ... "Postnatal Touch Stimulation Acutely Alters Corticosterone Levels and Glucocorticoid Receptor Gene Expression in the Neonatal ...

https://en.wikipedia.org/wiki/Harry_Harlow

It is biosynthesized from corticosterone by the enzyme 5α-reductase. DHC has central depressant effects and impairs long-term ... 125-. ISBN 978-4-431-29567-9. Dubrovsky, B.; Williams, D.; Kraulis, I. (1985). "Effects of corticosterone and 5?- ...

https://en.wikipedia.org/wiki/5α-Dihydrocorticosterone

... corticosterone and body-brain integration". Brain Research. 1476: 1-15. doi:10.1016/j.brainres.2011.12.049. PMID 22285436.. ...

https://en.wikipedia.org/wiki/Psychic_numbing

HNP4 inhibits corticotropin-stimulated corticosterone production. ENSG00000285318 GRCh38: Ensembl release 89: ENSG00000164821, ...

https://en.wikipedia.org/wiki/DEFA4

In 1938, Fleischmann and Kann determined that in addition to estrogen, a specific adrenal hormone, corticosterone, could cause ... See footnote 1 at Fleischmann, W.; Kann, S. (1938). "The Bitterling Ovipositor Reaction to Corticosterone". Science. 87 (2257 ... though it did open the door to an investigation of why corticosterone is significant in urine. Barnes, Broda Otto (1976). ...

https://en.wikipedia.org/wiki/Broda_Otto_Barnes

It is a derivative of corticosterone. 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the ...

https://en.wikipedia.org/wiki/18-Hydroxycorticosterone

The hormone known as corticosterone is activated by the hypothalamic-pituitary-adrenal axis. Corticosterone is activated when ... Cockrem, J. F. (2007). "Stress, corticosterone responses and avian personalities". Journal of Ornithology. 148: 169-178. doi: ...

https://en.wikipedia.org/wiki/Common_raven

Corticosterone is comparable to cortisol in this case.[30] For potassium to move out of the cell, cortisol moves an equal ... However, in cattle, corticosterone levels may approach[94] or exceed[4] cortisol levels.). The medulla of the adrenal gland ... Deoxycorticosterone → Corticosterone → 5α-Dihydrocorticosterone1 → 3α,5α-Tetrahydrocorticosterone1. 1.2. Aldosterone → 5α- ... Rapid administration of corticosterone (the endogenous type I and type II receptor agonist) or RU28362 (a specific type II ...

https://en.wikipedia.org/wiki/Cortisol

... corticosterone; 11β,21-dihydroxyprogesterone) 21-Deoxycortisol (11β,17α-dihydroxyprogesterone) Cortisol (hydrocortisone) ...

https://en.wikipedia.org/wiki/Deoxycortisol

Aldosterone synthase (18-hydroxylase; CYP11B2). Prevents the conversion of corticosterone into aldosterone. As such, AG is an ... 11β-Hydroxylase (CYP11B1). Prevents the conversion of 11-deoxycorticosterone and 11-deoxycortisol into corticosterone and ...

https://en.wikipedia.org/wiki/Aminoglutethimide

Buttemer, WA; Astheimer, LB; Wingfield, JC (1991). "The Effect of Corticosterone on Standard Metabolic Rates of Small Passerine ... Astheimer, L; Ramenofsky, M; Wingfield, JC; Buttemer, W (1989). "Corticosterone Feeding Behavior and Food Deprivation in ... Astheimer, LB; Buttemer, WA; Wingfield, JC (1992). "Interactions of corticosterone with feeding, activity and metabolism in ...

https://en.wikipedia.org/wiki/Pine_Siskin

The protein blocks α-MSH-induced secretion of corticosterone. Orthologs of AgRP, ASIP, MCIR, and MC4R have been found in ...

https://en.wikipedia.org/wiki/Agouti-related_peptide

5), corticosterone (C. 21H. 30O. 4), cortisone (C. 21H. 28O. 5) and aldosterone (C. 21H. 28O. 5). (Note that aldosterone and ... Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is mediated either by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they ...

https://en.m.wikipedia.org/wiki/Corticosteroid

Corticosterone. 0.18. 2.2. 12. 3.39. 0.09. 77.5. 19.0. 7.0. 3.28. 0.22. 78.1. 18.4 ...

https://en.m.wikipedia.org/wiki/Sex_hormone-binding_globulin

... and corticosterone share the first part of their biosynthetic pathways. The last parts are mediated either by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they ...

https://en.m.wikipedia.org/wiki/Aldosterone

Ki values for decynium-22 and corticosterone inhibition of OCT3 transport are respectively 10 and 100 times lower than Ki ... Transport is also inhibited by the chemical decynium-22 and physiological concentrations of corticosterone and cortisol. ... Gründemann D, Schechinger B, Rappold GA, Schömig E (1999). "Molecular identification of the corticosterone-sensitive ... a corticosterone-sensitive monoamine transporter, in the rat brain". J Comp Neurol. 512 (4): 529-555. doi:10.1002/cne.21921. ...

https://en.wikipedia.org/wiki/SLC22A3

"Vasoactive intestinal peptide stimulates adrenal aldosterone and corticosterone secretion". Endocrinology. 122 (5): 2090-2097. ...

https://en.wikipedia.org/wiki/ACTH_stimulation_test

This enzyme helps produce hormones called cortisol and corticosterone. The CYP11B2 gene provides instructions for making ...

https://en.wikipedia.org/wiki/Familial_hyperaldosteronism

The following code produces the image for corticosterone below. \documentclass{letter} \usepackage{epic,carom} \pagestyle{empty ...

https://en.wikipedia.org/wiki/XyMTeX

Corticosterone implanted chicks beg more frequently than non-implanted chicks. When there is a shortage of food, corticosterone ... Corticosterone increases begging effort and food provisioning rates by parents. ... begging indicating that juvenile hormone in insects could have a similar function to that of testosterone and corticosterone in ... by which juvenile hormone affects offspring growth in insects differ from those by which testosterone and corticosterone affect ...

https://en.wikipedia.org/wiki/Begging_in_animals

The circulating hormone, corticosterone, is one signal that arouses a hummingbird from torpor. Use and duration of torpor vary ... Hiebert, S. M.; Salvante, K. G.; Ramenofsky, M; Wingfield, J. C. (2000). "Corticosterone and nocturnal torpor in the rufous ...

https://en.wikipedia.org/wiki/Hummingbird

Higher corticosterone levels in breeding female Japanese quails were associated with female-biased sex ratios at laying. In ... Pike, TW; Petrie, M (2006). "Experimental evidence that corticosterone affects offspring sex ratios in quail". Proceedings of ...

https://en.wikipedia.org/wiki/Sex_allocation

Although production of cortisol is too inefficient to normalize ACTH, the 50-100-fold elevations of corticosterone have enough ... Consequently, levels of DOC, corticosterone, and 18-hydroxycorticosterone are elevated. Although these precursors of ...

https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_17α-hydroxylase_deficiency

... corticosterone to 18-hydroxycorticosterone, cortisol to 18-hydroxycortisol. Besides that, 11β-hydroxylase may be involved in ... 11-deoxycorticosterone to corticosterone; medium activity: progesterone to 11β-hydroxyprogesterone, testosterone to 11β- ... 11-Deoxycortisol Cortisol 11-Deoxycorticosterone Corticosterone As a mitochondrial P450 system, P450c11 is dependent on two ... has strong catalytic activity during conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone, ...

https://en.wikipedia.org/wiki/Steroid_11β-hydroxylase

In addition, parrots that feather-pluck have been found to have higher levels of corticosterone, a hormone secreted by many ... Owen, D.J; Lane, J.M. (2006). "High levels of corticosterone in feather-plucking parrots (Psittacus erithacus)". Veterinary ...

https://en.wikipedia.org/wiki/Feather-plucking

Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is either mediated by the ... aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). Aldosterone synthesis is stimulated by ...

https://en.wikipedia.org/wiki/Glucocorticoid_remediable_aldosteronism

2008) Stressor-specific alterations in corticosterone and immune responses in mice. Brain, behavior, and immunity 22 (1), 105- ...

https://en.wikipedia.org/wiki/Staci_Bilbo

Bortolotti G.R.; Marchant T.A.; Blas J.; German T. (2008). "Corticosterone in feathers is a long-term, integrated measure of ... Royo F.; Mayo S.; Carlsson H.E.; Hau J. (2008). "Egg corticosterone: A noninvasive measure of stress in egg-laying birds". ... heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ...

https://en.wikipedia.org/wiki/Animal_welfare_science

Corticosterone methyloxidase deficiency, also known as aldosterone synthase deficiency, is a disorder characterized by ... Genetic Testing Registry: Corticosterone methyloxidase type 1 deficiency *Genetic Testing Registry: Corticosterone ... the conversion of 11-deoxycorticosterone to corticosterone, the conversion of corticosterone to 18-hydroxycorticosterone, and ... Severe cases of corticosterone methyloxidase deficiency can result in seizures and coma and can be life-threatening. However, ...

https://medlineplus.gov/genetics/condition/corticosterone-methyloxidase-deficiency/

... *Formula: C29H52N2O4Si2 ...

https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C29H52N2O4Si2/c1-28-16-15-21

Corticosterone both inhibits protein synthesis and degrades proteins. Birds with increased levels of corticosterone will have ... Corticosterone has further developmental effects on birds. Increased levels of corticosterone in chicks leads to increased ... corticosterone can either facilitate or interrupt conditioned fear. Not only does corticosterone have effects on emotional ... Corticosterone inhibits feather growth: Potential mechanism explaining seasonal down regulation of corticosterone during molt. ...

https://en.wikipedia.org/wiki/Corticosterone

Surprisingly, treatment with anti-inflammatory glucocorticoid, corticosterone (CORT), enhanced rather than suppressed DFP- ...

https://www.cdc.gov/niosh/nioshtic-2/20045491.html

Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. This enzyme participates in ... In enzymology, a corticosterone 18-monooxygenase (EC 1.14.15.5) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating ... H2O The 3 substrates of this enzyme are corticosterone, reduced adrenal ferredoxin, and O2, whereas its 3 products are 18- ...

https://en.wikipedia.org/wiki/Corticosterone_18-monooxygenase

However, when stress was followed 24 h later by corticosterone in the drinking water, the surge in corticosterone was prevented ... We observed that post-stress corticosterone, given 1 day after acute stress in drinking water, reversed enhanced anxiety-like ... Together, these observations suggest that corticosterone, delivered through drinking water even 24 h after acute stress, is ... Strikingly, although the immobilization-induced surge in corticosterone by itself has delayed detrimental effects on amygdalar ...

https://www.nature.com/articles/s41386-020-0758-0?error=cookies_not_supported&code=e8eb9496-5fa2-4a87-8c38-61575567ae7a

... Antiserum for 3H Assay (Rabbit), for 10,000 Tubes Corticosterone Antiserum for use in 3H Assay ... Corticosterone Double Antibody RIA Kit The kit is ready to use and includes the following components: Antiserum, 6 standards, ... Corticosterone ELISA Kit for Rats The kit is ready to use and includes the following components: Microtiter Plate, 6 ... Corticosterone Antiserum for 125I Assay (Rabbit), for 1000 Tubes Antibody is purified from rabbit and is sufficient for 1000 ...

https://www.mpbio.com/diagnostics/endocrinology/corticosterone

Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...

https://www.echa.europa.eu/it/web/guest/substance-information/-/substanceinfo/100.000.018

The Corticosterone Double Antibody RIA Kit is intended for the measurement of corticosterone in a sample. It is specifically ... The Corticosterone ELISA Kit for Rats and Mice is a competitive immunoassay for the quantitative measurement of corticosterone ... Corticosterone antibody is purified from rabbit and is sufficient for 1000 tests. ...

https://www.mpbio.com/us/diagnostics/metabolism/corticosterone-0

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune ... Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune ... Corticosterone ≥98.5% (HPLC) Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21- ... Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It ...

https://www.sigmaaldrich.com/catalog/product/sigma/27840?lang=en®ion=US

We measured plasma corticosterone levels in actively flying migratory birds: in red knots, Calidris canutus, flying up to 10 h ... Role of Corticosterone during migration Long-distance migration requires many physiological and behavioural adaptations such as ... We investigated whether corticosterone, the most prevalent glucocorticoid in birds, is involved in the regulation of bird ... A strong increase in corticosterone when fat reserves are near exhaustion triggers an increase in the catabolism of protein and ...

https://www.vogelwarte.ch/en/projects/bird-migration/terminated-projects/role-of-corticosterone-during-migration

The plasma corticosterone (CORT) level was measured in morphine and saline control animals 1 day after the last injection of a ... Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent.. Geoffroy H1,2,3, Canestrelli ... No more alteration in stubby spines in the shell was detected in morphine-treated rats with a depletion of corticosterone, ... Since morphine-treated rats also presented an elevation of corticosterone level in plasma, we explored whether spine ...

https://www.ncbi.nlm.nih.gov/pubmed/30915438

Stress-induced corticosterone levels were also augmented in dyn(−/−) mice (d).. *p,0.05; **p,0.01; ***p,0.001 vs respective ... decrease in corticosterone serum levels in prodynorphin knockout mice. Although stress-induced increases in corticosterone ... Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.. Wittmann W1, ... No differences between the genotypes were observed in stress-induced hyperthermia (c). Basal corticosterone serum levels were ...

https://www.ncbi.nlm.nih.gov/pubmed/18800067?dopt=Abstract

... by Kathy Jones on September 8, 2013 at 8:10 ... These findings indicate that Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced ... has been shown to protect SH-SY5Y cells against corticosterone-induced damage. A recent study reported in the Neural ...

https://www.medindia.net/news/research-sheds-light-on-why-shuyusan-can-treat-corticosterone-induced-impairment-124748-1.htm

Neither dose of corticosterone affected the length of basal dendrites or spine density. Corticosterone was ineffective in ... Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. Journal. Hippocampus. Volume , Issue number ... In organotypic cultures (prepared from P5 rats) that were 14-21 days cultured in vitro, two doses of corticosterone (30 and 100 ... Exposing organotypic slices to 30 nM corticosterone reduced apical length in a more delayed manner: only neurons examined more ...

http://dare.uva.nl/search?metis.record.id=307468

A new study reveals a history of binge drinking leads to more instances of drinking under stress and when anxious in males, but not in females.... Read More... ...

https://neurosciencenews.com/neuroscience-terms/corticosterone/

... Bombi ... of this study was to examine whether acupuncture improves spatial cognitive impairment induced by repeated corticosterone (CORT ...

https://www.hindawi.com/journals/ecam/2012/670536/abs/

Li M et al. Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the ...

https://www.abcam.com/corticosterone-endogenous-steroid-hormone-ab143597.html

For baseline corticosterone, the top model included stand age with limited support for models that included vegetation cover. ... Mean baseline corticosterone for territorial male thrushes sampled in mature stands was 78.2 % higher than territorial males ... For handling-induced corticosterone, there was limited separation among candidate models, and only one model, containing stand ... Corticosterone in territorial male Swainsons Thrushes varies in relation to forest age but not vegetation cover. ...

https://link.springer.com/article/10.1007/s10336-013-1037-1

What is cortisol:corticosterone ratio? Meaning of cortisol:corticosterone ratio medical term. What does cortisol:corticosterone ... corticosterone ratio in the Medical Dictionary? cortisol:corticosterone ratio explanation free. ... redirected from cortisol:corticosterone ratio). Also found in: Dictionary, Thesaurus, Encyclopedia. cortisol. [kor´tĭ-sol] a ... cortisol:corticosterone ratio. the ratio between the two hormones is different between species and even between individual ...

https://medical-dictionary.thefreedictionary.com/cortisol%3Acorticosterone+ratio

The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus ... Corticosterone / pharmacology*. Dietary Fats / administration & dosage*. Female. Insulin / blood. Male. Muscle, Skeletal / drug ... The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus ... Corticosterone treatment resulted in enhanced energy expenditure. The results indicate that the development of breast muscle ...

http://www.biomedsearch.com/nih/Impaired-development-broiler-chickens-by/16458032.html

... and the ability of high levels of corticosterone to mo ... Male mice were implanted with a corticosterone pellet (192 mg/ ... Corticosterone pretreatment attenuated the kainate-induced influx of IgG at all time points. Immunohistochemical localization ... Kainate-induced seizures were scored at Stage 1 (Racine scale), and corticosterone pretreatment did not alter seizure activity ... Supraphysiological levels of the stress hormone corticosterone attenuate blood-brain barrier disruption and microglial ...

https://www.cdc.gov/niosh/nioshtic-2/20025056.html

Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro Message Subject. (Your Name) has forwarded a page ... This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent ...

https://science.sciencemag.org/content/164/3878/426

2018). Corticosterone levels reflect variation in metabolic rate, independent of stress. Sci. Rep. 8, 13020. doi:10.1038/ ... 2001). Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird. Am. J. Physiol ... Regressions of corticosterone (CORT) and glucose following stress in wandering gartersnakes (Thamnophis elegans). (A) Baseline ... 2014). Temperature has species-specific effects on corticosterone in alligator lizards. Gen. Comp. Endocrinol. 206, 184-192. ...

https://jeb.biologists.org/content/223/2/jeb203885

It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to ... Corticosterone / metabolism*, pharmacology. Fluorescent Antibody Technique. Hyperalgesia / metabolism. Intestinal Mucosa / drug ... It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to CPS ...

http://www.biomedsearch.com/nih/Corticosterone-mediates-stress-related-increased/23336591.html

Detect and quantitate human corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous ... Biotinylated corticosterone-BSA complex and free corticosterone (in standards or in samples) compete for binding to anti- ... When corticosterone-BSA binds to anti-corticosterone AlphaLISA acceptor beads, the beads come into close proximity. The ... The AlphaLISA® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, ...

http://www.perkinelmer.com/product/alphalisa-corticosteronekit-500pts-al3020c

Corticosterone ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of corticosterone in serum and ... Corticosterone ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of corticosterone in serum and ...

http://www.abnova.com/products/products_detail.asp?catalog_id=KA3385

... when administered a corticosterone treatment to mimic hypercorticism conditions, AdipoGR-KO mice exhibited an improved glucose ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ...

http://diabetes.diabetesjournals.org/content/early/2018/11/29/db17-1577

Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ... Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure ...

http://diabetes.diabetesjournals.org/content/early/2018/11/29/db17-1577.supplemental

Decreased IgM production along with an early rise in corticosterone followed by a subsequent decrease was noted for each RCI ... These results suggest that RCI-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and ... Skin Injuries Reduce Survival and Modulate Corticosterone, C-Reactive Protein, Complement Component 3, IgM, and Prostaglandin E ...

https://www.hindawi.com/journals/omcl/2013/821541/abs/

Surprisingly, treatment with anti-inflammatory glucocorticoid, corticosterone (CORT), enhanced rather than suppressed DFP-induced neuroinflammation. (cdc.gov)
Corticosterone (Cort) is a glucocorticoid hormone. (sigmaaldrich.com)
The purpose of this study was to examine whether acupuncture improves spatial cognitive impairment induced by repeated corticosterone (CORT) administration in rats. (hindawi.com)
The effects of corticosterone (CORT) administration on the development of muscular tissues of broiler chickens (Gallus gallus domesticus) fed with diets differing in lipid content were investigated. (biomedsearch.com)
The glucocorticoid hormone corticosterone (CORT) has classically been used in ecophysiological studies as a proxy for stress and energy mobilization, but rarely are CORT and the energy metabolites themselves concurrently measured. (biologists.org)
It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to CPS. (biomedsearch.com)
Corticosterone (CORT) is a member of corticosteroids and is also known as 17-deoxycortisol or 11β 21-dihydroprogesterone. (perkinelmer.com)
Here, we exposed mice to the primary stress hormone corticosterone (CORT) during early adolescence (postnatal days 31-42), then tested behavioral flexibility in adulthood using an instrumental reversal learning task. (frontiersin.org)
Evidence from recent studies has suggested that the avian stress-related hormone corticosterone (CORT) may play a role in immunocompetence and sexual selection. (biologists.org)
We investigated latitudinal variation in corticosterone (CORT) response to chronic predator stress in Rana temporaria tadpoles along a 1500-km latitudinal cline in Sweden tadpoles, in a laboratory experiment. (diva-portal.org)
Here we address this issue by examining the effects of chronic exposure to the stress hormone, corticosterone (CORT), in both adolescent and adult animals. (frontiersin.org)
It has been well-established that compared to adults, adolescent animals exhibited different hypothalamo-pituitary-adrenal (HPA) axis functions in that they showed prolonged exposure to stress hormones, including adrenocorticotropic hormone (ACTH) and corticosterone (CORT), in response to both acute and chronic stress ( Romeo, 2013 ). (frontiersin.org)
The massive meat production of broiler chickens make them continuously exposed to potential stressors that stimulate releasing of stress-related hormones like corticosterone (CORT) which is responsible for specific pathways in biological mechanisms and physiological activities. (sigmaaldrich.com)
the first group received a daily intramuscular injection of 5 mg/kg BW corticosterone dissolved in 0.5 ml ethanol:saline solution (CORT group), while the second group received a daily intramuscular injection of 0.5 ml ethanol:saline only (CONT group). (sigmaaldrich.com)
GA enhances the ability of corticosterone (Cort) to inhibit IL-1β- and forskolin- induced phospholipase (PLA2) activity. (nih.gov)
I examined 1) the ontogeny of the corticosterone (CORT) response (both total and free hormone levels), 2) changes in corticosteroid receptor levels in brain with age, and 3) effects of acute and extended elevation of CORT on behavior and growth. (utexas.edu)
Rats have rhythmic clock gene expression in the vmPFC that requires appropriate diurnal circulatory patterns of corticosterone (CORT), suggesting the presence of CORT-entrained intrinsic circadian clock function within the PFC. (eneuro.org)
We examined the link between nest shelter, baseline corticosterone (CORT) levels and hatching success in common eiders (Somateria mollissima) incubating at nest sites with different levels of shelter. (gla.ac.uk)
Corticosterone (CORT) is a glucocorticoid hormone that maintains energy balance and can modulate foraging behaviors in seabirds. (acap.aq)
Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. (edu.au)
Maternal stress can impair foetal development and program sex-specific disease outcomes in offspring through the actions of maternally produced glucocorticoids, predominantly corticosterone (Cort) in rodents. (edu.au)

In studies on rats, the fluctuations of corticosterone concentration are shown to prevent stress' impairment of recognition memory in lower amounts. (wikipedia.org)
Further, stress elevated serum corticosterone levels in rats that received vehicle in the drinking water. (nature.com)
The Corticosterone ELISA Kit for Rats and Mice is a competitive immunoassay for the quantitative measurement of corticosterone in rat and mouse serum or plasma. (mpbio.com)
Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro . (sigmaaldrich.com)
Since morphine-treated rats also presented an elevation of corticosterone level in plasma, we explored whether spine alterations induced by morphine treatment in the nucleus accumbens could be affected by the depletion of the hormone. (nih.gov)
No more alteration in stubby spines in the shell was detected in morphine-treated rats with a depletion of corticosterone, while a significant increase was observed in mushroom spines in the shell and stubby spines in the core. (nih.gov)
In organotypic cultures (prepared from P5 rats) that were 14-21 days cultured in vitro, two doses of corticosterone (30 and 100 nM) were tested. (uva.nl)
Corticosterone is produced under the control of ACTH and the production has a circadian rhythm with peak levels in the latter portion of the day in nocturnal animals like rats and is believed to play a decisive role in sleep-wake cycles. (biovendor.com)
The effects of oleuropein, a phenolic compound in extra virgin olive oil, on protein metabolism were investigated by measuring testicular testosterone and plasma corticosterone levels in rats fed diets with different protein levels. (nih.gov)
After 28 days of feeding, the testosterone level in the testis was significantly higher and the plasma corticosterone level was significantly lower in rats fed the 40% casein diet with oleuropein than in those fed the same diet without oleuropein. (nih.gov)
These findings suggest that dietary supplementation with 0.1 g/100 g oleuropein alters the levels of hormones associated with protein anabolism by increasing urinary noradrenaline and testicular testosterone levels and decreasing plasma corticosterone level in rats fed a high-protein diet. (nih.gov)
Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats. (nel.edu)
The present work was aimed to evaluate whether swimming-exercise-induced stress leads to changes in the chronobiology parameters of the circadian rhythms of melatonin and corticosterone, and in the number and phagocytosis of peritoneal macrophages in 3-month-old male Wistar rats. (nel.edu)
Basal plasma corticosterone was found to correlate positively with an active response to a novel environment and inescapable stress across all rats. (nih.gov)
Elevation of plasma corticosterone levels and hippocampal glucocorticoid receptor translocation in rats: a potential mechanism for cognition impairment following chronic low-power-density microwave exposure. (emf-portal.org)
It is not clear whether the disrupted corticosterone rhythm, resulting from high-fat feeding contributes to attenuated meal anticipation in high-fat fed rats. (salford.ac.uk)
Our aim was to better characterize meal anticipation in rats fed a low- or high-fat diet, and to better understand the role of corticosterone in this process. (salford.ac.uk)
We also used the glucocorticoid receptor antagonist, RU486, to dissect out the role of corticosterone in meal anticipation in rats given daily access to a meal with different fat content. (salford.ac.uk)
Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. (sun.ac.za)
Neither the spontaneous outflow nor the electrically stimulated release of [3H]NA from dorsal hippocampal slices of untreated rats was affected by exposure of the slices to corticosterone (10-7 M - 10-4 M) in the superfusion buffer. (sun.ac.za)
Thus, chronic corticosterone treatment of rats altered the noradrenergic system of the pons-medulla, but did not change the α2-adrenoceptor-mediated modulation of NA release in the dorsal hippocampus, a major terminal area of the LC neurons. (sun.ac.za)
Bipolar electrodes were implanted into the CA1 pyramidal cells of the dorsal hippocampus and the effect of electrical stimulation of these cells on corticosterone secretion was investigated in freely moving rats. (sun.ac.za)
It is well established that adrenocortical hormones (corticosterone in rats, cortisol in humans) influence many aspects of cognitive performance. (pnas.org)
Systemic injections of stress-level doses of corticosterone administered to rats shortly before retention testing impair retrieval in tasks that rely on spatial or contextual information, including water-maze and inhibitory avoidance (ref. 22 and B.R., D.J.-F.d.Q., Gustav Schelling, and J.L.M., unpublished observations). (pnas.org)
While cortisol and corticosterone are both produced in response to stress in humans, corticosterone is the predominant glucocorticoid produced in mice and rats. (neogen.com)
While not always predictive of environmental stress in the wild, conditions such as starvation, rapid temperature change, or changes in daily routine can cause increased corticosterone levels in laboratory mice and rats. (neogen.com)
Conditions such as starvation, rapid temperature change, or changes in daily routine can cause increased corticosterone levels in laboratory mice and rats. (medimabs.com)
To test this hypothesis, three 100 mg pellets of corticosterone were implanted subcutaneously in each of nine rats for two weeks. (byu.edu)

A sizable amount of research has been done on the effects of corticosterone in birds. (wikipedia.org)
The extract increased the catalase and superoxide dismutase activities and reversed the effects of corticosterone. (springer.com)
The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. (sun.ac.za)

Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms. (sciencemag.org)
M. I. Cordero, J. J. Merino and C. Sandi, "Correlational Relationship between Shock Intensity and Corticosterone Secretion on the Establishment and Subsequent Expression of Contextual Fear Conditioning," Behavioral Neuroscience, Vol. 112, No. 4, 1998, pp. 885-891. (scirp.org)
K , Bethea, C & Van De Kar, LD 1984, ' Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion ', Federation Proceedings , vol. 43, no. 3. (elsevier.com)
Van De Kar, L. D. / Serotonin mediated effect of fenfluramine on prolactin but not corticosterone secretion . (elsevier.com)
Wand, GS 1989, ' Ethanol differentially regulates proadrenocorticotropin/endorphin production and corticosterone secretion in ls and ss lines of mice ', Endocrinology , vol. 124, no. 1, pp. 518-526. (elsevier.com)

We pointed out the main factors increasing corticosterone levels in voles and features of the studied species that may determine the differences in their reaction including: the width of the ecological niche, spatial mobility, and predation pressure. (wind-watch.org)

These behavioral data are supported by an approximal 30% reduction in corticotropin-releasing hormone (CRH) mRNA expression in the hypothalamic paraventricular nucleus and central amygdala and an accompanying 30-40% decrease in corticosterone serum levels in prodynorphin knockout mice. (nih.gov)
Although stress-induced increases in corticosterone levels were attenuated in prodynorphin knockout mice, they were associated with minor increases in depression-like behavior in the tail suspension and forced swim tests. (nih.gov)
Supraphysiological levels of the stress hormone corticosterone attenuate blood-brain barrier disruption and microglial activation in hippocampus of C57BL/6J mice treated with kainic acid. (cdc.gov)
Male mice were implanted with a corticosterone pellet (192 mg/kg/d) to mimic the sustained activation of the HPA axis associated with chronic stress, and allowed to recover for seven days. (cdc.gov)
Interestingly, when administered a corticosterone treatment to mimic hypercorticism conditions, AdipoGR-KO mice exhibited an improved glucose tolerance and insulin sensitivity. (diabetesjournals.org)
however, this WD-induced increase in plasma corticosterone was significantly attenuated in V1b⁻/⁻ mice. (nih.gov)
H. Tomizawa, D. Matsuzawa, S. Matsuda, D. Ishii, C. Sutoh and E. Shimizu, "A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice," Journal of Behavioral and Brain Science , Vol. 3 No. 5, 2013, pp. 415-421. (scirp.org)
Environmental enrichment during rearing alters corticosterone levels, thymocyte numbers, and aggression in female BALB/c mice: E.K. Hutchinson, et al. (cosmobio.co.jp)
This work investigated the antioxidant and antidepressant-like effects of ethyl acetate extract from Eugenia catharinensis in mice treated with corticosterone (20 mg/Kg). (springer.com)
Our results showed that the extract decreased the immobility time of mice in the forced swimming test and that the extract was able to reverse the effect caused by corticosterone. (springer.com)
Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. (uzh.ch)
We found that 20-min and 3-h restraint stress did not influence CSD susceptibility in mutant or wild-type mice, despite elevated levels of plasma corticosterone. (uu.nl)
mg/kg corticosterone increased CSD frequency exclusively in mutant mice, while corticosterone plasma levels were similarly elevated in mutants and wild types. (uu.nl)
Male and female mice were injected with MA (1 mg/kg) or saline for comparison of plasma corticosterone and analysis of the immediate early gene c-Fos in brain. (wiley.com)
There was a prolonged elevation in corticosterone levels in female compared to male mice. (wiley.com)
Serum corticosterone levels also paralleled pro-ACTH/endorphin production in both lines of mice. (elsevier.com)
Long-term consumption of a sugar-sweetened beverage in early age increases corticosterone and promotes social aggression in mice. (foundmyfitness.com)

Fig. 4: Post-stress corticosterone treatment leads to a reduction in stress-induced increase in serum corticosterone levels. (nature.com)
Exposure of the rat strains to stress induced a significant elevation in serum corticosterone levels but did not facilitate LTD expression. (pnas.org)
The mixture is then diluted 1:50 or greater with Assay Buffer and added directly to the well of the provided microtiter plate.Typical c57bl/6j mouse serum corticosterone levels fall at 0.08 ± 0.01 µM and therefore can be measured in this assay without extraction. (being-bioreactive.com)

Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. (wikipedia.org)
During the last years the glucocorticoid hormone corticosterone was discussed as a candidate, which might orchestrate the energetic needs during migration. (vogelwarte.ch)
Here, we examined whether the adrenal hormone, corticosterone, and brain corticotropin-releasing factor (CRF) were involved in such reinstatement. (jneurosci.org)
Here, we determined whether the adrenal hormone corticosterone and brain corticotropin-releasing factor (CRF) are involved in the effects of stress and heroin-priming on relapse to heroin-seeking. (jneurosci.org)
Corticosterone (C21H30O4, also called 11β,21-Dihydroxyproges-terone, Reichstein's Sub-stance H, or Kendall's Compound B) is, like cortisol and cortisone, a glucocorticoid hormone secreted from the cortex of adrenal gland. (biovendor.com)
For the analysis of corticosterone concentrations in the faeces, we used ELISA tests with antibodies for this hormone. (wind-watch.org)
We sampled 329 sage-grouse across four sites (two grazed and two ungrazed) encompassing 13 600 km 2 during the spring and late summer-early autumn of 2005 to evaluate whether demographic factors, breeding status, plasma protein levels, and residence in a cattle-grazed habitat were associated with the stress hormone corticosterone. (usgs.gov)
Corticosterone, which is a stress hormone, increased with laying order within a clutch of eggs, probably because egg production requires a lot of energy. (spectroscopynow.com)
They also found that the daytime effects of nicotine were greatest when levels of the stress hormone corticosterone were high. (ciggyfree.com)
D'Alba, L. , Spencer, K.A. , Nager, R.G. and Monaghan, P. (2011) State dependent effects of elevated hormone: Nest site quality, corticosterone levels and reproductive performance in the common eider. (gla.ac.uk)
Here we investigated effects of acute restraint stress and of the stress hormone corticosterone on CSD susceptibility as surrogate migraine marker, in a transgenic mouse model of familial hemiplegic migraine type 1 (FHM1), which displays increased glutamatergic cortical neurotransmission and increased propensity for CSD. (uu.nl)
Corticosterone , also known as 17-deoxycortisol and 11β,21-dihydroprogesterone , [1] is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands in rodents and other non-human animals. (worldheritage.org)
Corticosterone is a stress hormone known to modulate social aggression. (foundmyfitness.com)

There was no effect of corticosterone treatment on anxiety behavior in adults.Thus, I show that high maternal corticosterone is transferred to avian egg yolk and that it has lasting effects on offspring development and adult phenotype. (washington.edu)
Vazquez-Palacios G, Retana-Marquez S, Bonilla-Jaime H, Velazquez-Moctezuma J. Further definition of the effect of corticosterone on the sleep-wake pattern in the male rat. (biovendor.com)
The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone. (uu.nl)

Together, these observations suggest that corticosterone, delivered through drinking water even 24 h after acute stress, is capable of reversing the delayed enhancing effects on BLA synaptic connectivity and anxiety-like behavior. (nature.com)
The results suggest that corticosterone administration enhanced hepatic fatty acid synthesis and resulted in the redistribution of energy to abdominal store from peripheral tissues. (biomedsearch.com)

We measured plasma corticosterone levels in actively flying migratory birds: in red knots, Calidris canutus , flying up to 10 h in a wind tunnel (collaboration with the University of Lund) and in free-ranging passerines caught out of migratory flight. (vogelwarte.ch)
We compared the plasma corticosterone concentrations of birds with different migration strategies, namely long-distance, short-distance and irruptive migrants. (vogelwarte.ch)
These findings suggest that it is relevant to maintain plasma corticosterone levels low during hippocampal development. (uva.nl)
Corticosterone ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of corticosterone in serum and plasma and in extracted fecal samples. (abnova.com)
Here I show that high plasma corticosterone in a laying bird corresponds to high corticosterone in the yolk of her eggs. (washington.edu)
I then demonstrate that elevated yolk corticosterone has a range of effects on offspring development and adult phenotype.Female quail from selected for heightened plasma corticosterone response to capture and restraint lay eggs with higher yolk corticosterone than quail selected for a low plasma corticosterone response. (washington.edu)
This difference in yolk corticosterone concentration is particularly interesting given that baseline corticosterone levels do not differ between the two lines.Experimentally elevating plasma corticosterone in laying quail increased corticosterone concentration in the yolk of their eggs. (washington.edu)
Chicks that hatched from eggs laid by females implanted with corticosterone grew more slowly than controls, and showed higher plasma corticosterone response to capture and restraint as adults.To determine whether the effects of elevated maternal corticosterone were mediated by transfer of the steroid itself to yolk, yolk corticosterone concentration was manipulated directly. (washington.edu)
Since most of corticosterone in blood is bound to a plasma protein called corticosterone-binding globulin (CBG), the determination of blood corticosterone with presently available commercial assay kits requires an initial extraction procedure. (biovendor.com)
Comprehensive growth performance, immune function, plasma biochemistry, gene expressions and cell death morphology responses to a daily corticosterone injection course in broiler chickens. (sigmaaldrich.com)
Radioimmunoassay was used to determine the plasma levels of melatonin and corticosterone. (nel.edu)
Future work should also consider applying the LC-MS/MS technique when measuring corticosterone in eggs laid by females experiencing stressful conditions, and when assessing plasma-to-yolk transfer rates," said the researchers. (spectroscopynow.com)
Plasma corticosterone levels were assessed using an ELISA. (wku.edu)
Plasma corticosterone and monoamines-5-hydroxy tryptamine (5-HT), norepinephrine (NE), epinephrine (E) and dopamine (DA) in cortex, hypothalamus and hippocampus regions of brain were determined in animals under different stressful conditions. (ijp-online.com)
Subjecting the animals to AS (immobilization for 150 min once only) resulted in significant elevation of plasma corticosterone levels and brain monoamine levels. (ijp-online.com)
In the CUS regimen (different stressors for 7 days), plasma corticosterone levels were significantly elevated whereas the levels of 5-HT, NE, E, and DA were depleted significantly. (ijp-online.com)
Pretreatment with MC (200 and 400 mg/kg) attenuated the CUS-induced changes in the levels of above monoamines in cortex, hypothalamus, and hippocampus regions of brain and plasma corticosterone in a dose-dependent manner. (ijp-online.com)
Basal levels of plasma corticosterone were measured using radioimmunoassay. (nih.gov)
Overall, SHR showed a more active response in the elevated plus-maze and forced swim test than WKY, regardless of treatment, and were also found to have higher basal plasma corticosterone compared to WKY. (nih.gov)
Maternal separation increased basal levels of plasma corticosterone in SHR females only, possibly through adaptive mechanisms involved in maintaining their active response in behavioural tests. (nih.gov)
Basal plasma corticosterone levels of SHR and WKY males (M) and females (F), maternally separated (MS) or non-maternally separated (nMS). (nih.gov)
The IBL International Corticosterone (Human, Rat, Mouse) ELISA is an enzyme immunoassay for the quantitative measurement of Corticosterone in serum and plasma. (ibl-international.com)
Microwave exposure increased levels of plasma corticosterone , glucocorticoid receptor nuclear translocation ( microwave exposure caused a decrease in the cytoplasmic signal and an increase in the nuclear signal compared to sham exposed control) and apoptosis in the hippocampus . (emf-portal.org)
Thus, sex differences in MA-induced plasma corticosterone levels and activation of distinct brain regions and proteins involved in HPA axis regulation may contribute to sex differences in acute effects of MA on the brain. (wiley.com)
Methamphetamine induces a prolonged plasma corticosterone response in females compared to males. (wiley.com)
These findings indicate a sex difference in the neural regulation of methamphetamine-induced plasma corticosterone release. (wiley.com)
Results of this study will be used in conjunction with plasma corticosterone assays to validate the use of leukocytes profiles for determining stress levels in pitvipers. (uark.edu)
Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of acute stressors on plasma corticosterone and leukocyte redistribution. (elsevier.com)
Our results showed that exposure to chronic variable stress increased basal plasma corticosterone levels and that both, chronic restraint and variable stresses, promote higher corticosterone levels in response to a novel environment, but not to a challenge restraint stress, as compared to the control (non-stressed) group. (unesp.br)
Most RIAs or EIAs require solvent extraction techniques to measure serum or plasma corticosterone levels, however extraction may be very difficult or impossible with mouse samples due to the large volumes of plasma or serum required for most extraction protocols. (being-bioreactive.com)
Some kits allow the quantification of corticosterone from as little as 1 ul serum / plasma. (being-bioreactive.com)
The principle of these kits is that serum or plasma samples are treated with an equal volume of a special Dissociation Reagent that liberates the corticosterone from any binding proteins. (being-bioreactive.com)
The DetectX ® Corticosterone Enzyme Immunoassay kit measures corticosterone present in tissue culture, serum, plasma and fecal samples. (antibody-antibodies.com)
Cockerels were exercised to observe the influence of physical activity on plasma corticosterone concentrations. (uark.edu)
The plasma corticosterone levels as determined by radioimmunoassay showed extreme variations within collections. (uark.edu)
The causes for the wide variation of plasma corticosterone levels in these birds remain unknown. (uark.edu)

During refuelling when birds are in a resorptive state slightly elevated corticosterone concentrations seem to support fuel deposition. (vogelwarte.ch)
Over 25 days of testing, a U-shaped relationship emerged between the corticosterone concentrations and the timing of breeding. (spectroscopynow.com)
Exposure to each stressor elevated corticosterone concentrations, with restraint (a putative psychological stressor) evoking a significantly higher glucocorticoid response than other stressors. (elsevier.com)

The IBL Corticosterone (Human, Rat, Mouse) ELISA Kit is a solid phase enzyme-linked immunosorbent assay (ELISA), based on the principle of competitive binding. (ibl-international.com)
This is an ELISA (Enzyme-Linked ImmunoSorbent Assay) for the quantitative analysis of Corticosterone levels in biological fluid. (neogen.com)

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. (sigmaaldrich.com)
Corticosterone is a glucocorticoid secreted by the adrenal cortex in response to stress. (neogen.com)
However, in humans , corticosterone is the primary glucocorticoid that is produced primarily in the zona fasciculata of the adrenal cortex . (worldheritage.org)
Corticosterone is produced in response to stimulation of the adrenal cortex by ACTH and is the precursor of aldosterone. (antibody-antibodies.com)

These hormones (primarily cortisol in primates, and corticosterone in birds, reptiles and rodents) are released in response to stressful environmental events, and are crucial in initiating the `flight or fight' response as well as a range of essential physiological and behavioural reactions to stress ( Nelson, 1995 ). (biologists.org)

These results suggest that high physiological levels of corticosterone, via activation of the glucocorticoid receptor, can, during the course of only a few hours, reduce the dendritic complexity of CA1 pyramidal neurons in young, developing hippocampal tissue. (uva.nl)
Staining with Isolectin B4 revealed numerous microglial cells throughout the hippocampal parenchyma at 12 hours post treatment, and an attenuation in the quantity of microglia by corticosterone pretreatment. (cdc.gov)
Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood: N. Lajud, et al. (cosmobio.co.jp)
Chronic corticosterone treatment (14 days) did not alter the α2-adrenoceptor-mediated modulation of [3H]NA release from dorsal hippocampal slices. (sun.ac.za)
To address the question whether corticosterone mediates the stress-induced up-regulation of reelin gene expression, we used age-matched hippocampal slice cultures derived from male and female mouse pups. (ovid.com)

In contrast, breeding males showed much lower corticosterone levels during the breeding season than all other classes, and were the only class that showed an increase of corticosterone from the breeding to the non-breeding season. (uzh.ch)
WT and HP parrots showed lower corticosterone levels than FPP parrots. (peerj.com)

Studies show that the modification of certain chemical and brain processes that affect corticosterone levels can also impact stress effects on memory. (wikipedia.org)

While the team's research could shed light on why people smoke and how nicotine affects them, Stitzel says more research is needed to determine the role that melatonin plays in altering the effects of nicotine, and whether the correlation between higher corticosterone levels and nicotine sensitivity is a coincidence. (ciggyfree.com)

Corticosterone was ineffective in changing morphology of the apical dendrites when tested in the presence of the glucocorticoid receptor antagonist RU38486. (uva.nl)
Furthermore, posttraining intrahippocampal infusions of corticosterone or synthetic glucocorticoid receptor (GR) agonists enhance memory consolidation on a variety of tasks, whereas infusions of a GR antagonist or GR antisense impair memory consolidation ( 10 - 16 ). (pnas.org)

During migratory flight, when birds are in a fasting state, slightly elevated baseline levels of corticosterone promote the mobilisation of the energy stores. (vogelwarte.ch)
For baseline corticosterone, the top model included stand age with limited support for models that included vegetation cover. (springer.com)
Mean baseline corticosterone for territorial male thrushes sampled in mature stands was 78.2 % higher than territorial males sampled in early seral stands. (springer.com)
Despite previous research that has shown hardwood cover is an important component of breeding habitat quality for thrushes, our investigation found limited evidence that vegetation cover was associated with either baseline or handling-induced corticosterone levels. (springer.com)
Given that early seral and mature conifer forests are characterized by markedly different habitat features, we hypothesize that the observed differences in baseline corticosterone represent either reduced fitness of male thrushes in mature stands or an adaptive adjustment of glucocorticoid levels to match local environmental conditions that equalize fitness across stands of different ages. (springer.com)
All groups showed a spike in corticosterone levels immediately following exercise which returned to baseline at one-hour post. (wku.edu)

Decreased IgM production along with an early rise in corticosterone followed by a subsequent decrease was noted for each RCI situation. (hindawi.com)
These measures were significantly attenuated in response to a high-fat diet, and animals on this diet exhibited a postanticipatory rise in corticosterone. (salford.ac.uk)

Diurnal variations in lipopolysaccharide-induced sleep, sickness behavior and changes in corticosterone levels in the rat. (mpg.de)
Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex. (semanticscholar.org)

Dietary restriction causes chronic elevation of corticosterone and enhances stress response in red-legged kittiwake chicks. (biovendor.com)

The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase. (sigmaaldrich.com)

The AlphaLISA ® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). (perkinelmer.com)
On the other hand, the present assay kit for corticosterone newly developed by our laboratory provides a tool for direct determination of corticosterone in blood by simple dilution of blood samples with the diluent included in the kit. (biovendor.com)

Large comb (LC) broiler cockerels, with high levels of testosterone and corticosterone, survived acute heat stress while small comb (SC) cockerels, with low levels of testosterone and corticosterone were more susceptible to heat stress and suffered higher mortality rates. (umm.ac.id)
To determine whether steroid hormones, testosterone and corticosterone, influence the expression of HSP in chickens, exogenous testosterone and corticosterone were implanted in LC capons and metyrapone-fed LC capons, respectively. (umm.ac.id)
The results suggested that the steroid hormones, testosterone and corticosterone, are involved in the expression of HSP, which are associated with acquired and maintained thermoresistance in domestic chickens. (umm.ac.id)

Although corticosterone levels rise also during acute stress, the latter likely triggers a spatiotemporally more complex biological response with multiple positive and negative modulators which may not be adequately modeled by exogenous administration of corticosterone alone. (uu.nl)

Corticosterone enhances chlorpyrifos-induced neuroinflammation. (cdc.gov)
Zhao J, Peng L, Zheng W, Wang R, Zhang L, Yang J, Chen H. Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells. (mdpi.com)

Corticosterone was administered at levels that individuals enduring chronic stressors (i.e., long-term inclement weather, food shortage, anthropogenic pollution) might experience in the wild. (biomedcentral.com)
The purpose of the present study was to compare the effect of two different stress paradigms (chronic restraint or variable stress) on behavioral and corticosterone release to a subsequent exposure to stressors. (unesp.br)
Considering that the HPA axis might respond differently when it is challenged with a novel or a familiar stressor we investigated the changes in the corticosterone levels following the exposure to two stressors: restraint (familiar stress) or forced novelty (novel stress). (unesp.br)

We observed that post-stress corticosterone, given 1 day after acute stress in drinking water, reversed enhanced anxiety-like behavior 10 days later. (nature.com)
We tested the effects of adrenalectomy, chronic exposure to the corticosterone synthesis inhibitor metyrapone (100 mg/kg, s.c., twice daily), acute exposure to metyrapone, acute intracerebroventricular injections of CRF (0.3 and 1.0 μg), and intracerebroventricular injections of the CRF antagonist α-helical CRF (3 and 10 μg). (jneurosci.org)

Immunoreactive corticosterone and corticosterone metabolites (ICCM) were quantified in excreta of permanently single housed (n=10) and permanently pair housed (n=20) roosters. (diva-portal.org)
Corticosterone was measured in feces as immunoreactive corticosterone metabolites (ICM). (usgs.gov)

Stress significantly decreased the MESOR and amplitude of the melatonin rhythm, and significantly increased the MESOR of the corticosterone rhythm. (nel.edu)
In the first two experiments corticosterone significantly decreased the noradrenaline (NA) and dopamine (DA) levels in the pons-medulla, an area which contains the A1-A7 noradrenergic cell groups, while the NA and DA levels in the dorsal hippocampus remained unchanged. (sun.ac.za)
Quantitative determination of mRNA levels revealed that corticosterone treatment significantly up-regulated reelin mRNA expression in male, but not in female hippocampi. (ovid.com)

Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. (abcam.com)
Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner. (biomedsearch.com)

Corticosterone is a major indicator of stress and is the major stress steroid produced in non-human mammals. (antibody-antibodies.com)

Birds with increased levels of corticosterone will have slower feather growth during their molting period and an extended period of poor flight. (wikipedia.org)
As a result, many birds have reduced levels of corticosterone when they moult so as to prevent the degradation of their new feathers. (wikipedia.org)
Corticosterone has further developmental effects on birds. (wikipedia.org)
In the short term this leads to higher chance of obtaining food, but in the long term, increased corticosterone in early life compromises the birds cognitive functioning (problem solving, association of visual cue with food, etc. (wikipedia.org)
We investigated whether corticosterone, the most prevalent glucocorticoid in birds, is involved in the regulation of bird migration. (vogelwarte.ch)
Overall levels of calbindin were higher in the HP of corticosterone-treated birds, due almost entirely to elevated calbindin expression in the dorsolateral subdivision of the HP only. (ovid.com)
Corticosterone greatly impacted mortality: half of the corticosterone-implanted cardinals died between five - 11 days post-inoculation whereas only one of nine empty-implanted (control) birds died. (biomedcentral.com)
No differences were found in viral titer between corticosterone- and empty-implanted birds. (biomedcentral.com)
In sum, this study indicates that elevated corticosterone could affect the survival of WNV-infected wild birds, suggesting that populations may be disproportionately at-risk to disease in stressful environments. (biomedcentral.com)

Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. (wikipedia.org)

The purpose of the present study was to compare the fecal corticosterone levels of companion African grey parrots kept as wild-type parrots (WT), healthy pet parrots (HP) and feather picking pet parrots (FPP) during the breeding season and out of the breeding season. (peerj.com)
A statistical trend between fecal corticosterone concentration in the different seasons for the WT parrots (P=0.085) was observed, but not for the other groups. (peerj.com)

Endogenous Corticosterone of a sample competes with a Corticosterone-horseradish peroxidase conjugate for binding to the coated antibody. (ibl-international.com)
The heat-induced synthesis of HSP was depressed by caponization and depressed further in the capons fed metyrapone, which blocks the synthesis pathway of endogenous corticosterone in adrenal glands. (umm.ac.id)

Using an important zoonotic pathogen, West Nile virus (WNV) and a competent host, the Northern Cardinal ( Cardinalis cardinalis ), we tested the effects of exogenous corticosterone on response to WNV infection. (biomedcentral.com)
The exogenous testosterone and to a lesser degree, corticosterone, stimulated the expression of HSP in heat-stressed capons. (umm.ac.id)

The Corticosterone Double Antibody RIA Kit is intended for the measurement of corticosterone in a sample. (mpbio.com)
Corticosterone antibody is purified from rabbit and is sufficient for 1000 tests. (mpbio.com)
Biotinylated corticosterone-BSA complex and free corticosterone (in standards or in samples) compete for binding to anti-corticosterone antibody that is conjugated to AlphaLISA Acceptor beads. (perkinelmer.com)
The microtiter wells are coated with a polyclonal antibody directed towards an antigenic site on the Corticosterone molecule. (ibl-international.com)
This test kit operates based on competition between the enzyme conjugate and the Corticosterone in the sample for a limited number of binding sites on the antibody coated plate. (neogen.com)
The binding reaction is initiated by the addition of a polyclonal antibody to corticosterone. (antibody-antibodies.com)
RABBIT ANTI CORTICOSTERONE-POLYCLONAL ANTIBODY antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of RABBIT ANTI CORTICOSTERONE-POLYCLONAL ANTIBODY. (antibody-antibodies.com)

Fig. 1: Corticosterone in drinking water after stress prevents increase in anxiety-like behavior 10 days later. (nature.com)
Male, but not female, chicks that hatched from eggs injected with corticosterone grew more slowly than controls, and female, but not male, offspring showed a decreased corticosterone response as adults.Finally, eggs were injected with corticosterone and chick performance in a maze, and adult expression of anxiety behavior were quantified to investigate the effects of elevated yolk corticosterone on cognitive ability and behavior. (washington.edu)
We also found that the correlation between corticosterone levels and freezing behavior during extinction was disrupted in the pair-exposure situation. (scirp.org)
The pair-exposure changed an association between corticosterone levels and freezing behavior during extinction. (scirp.org)
S. E. File and L. A. Peet, "The Sensitivity of the Rat Corticosterone Response to Environmental Manipulations and to Chronic Chlordiazepoxide Treatment," Physiology & Behavior, Vol. 25, No. 5, 1980, pp. 753-758. (scirp.org)
2) the observed highest level of corticosterone in FPP parrot suggests a role of stress in this self-injuring stereotypic behavior. (peerj.com)

L.B.M. and A.L.L. were supported by National Science Foundation (grant #0920475) during writing and for corticosterone assays. (springer.com)
Top) GMC were incubated for 48 h with combinations of IL-1β (5 nM), corticosterone (50 nM), and glycyrrhetinic acid (5 μM), and PLA2 assays were performed. (nih.gov)

Corticosterone is also being studied in different fields such as impairment of long-term memory retrieval, chronic corticosterone elevation due to dietary restrictions and response to burn injuries etc. (biovendor.com)
The common vole showed a distinct physiological response − the individuals living near the wind turbines had a higher level of corticosterone. (wind-watch.org)
Corticosterone is thought to be the main glucocorticoid secreted in response to stressful exercise, while melatonin buffers the adverse immunological effects of stress. (nel.edu)
These data confirm that melatonin and corticosterone act as modulators of the innate immune response, and that the circadian rhythm of the two hormones are altered in situations of stress. (nel.edu)
Basal levels of corticosterone correlate with the behavioural response to early life trauma, and may therefore provide a useful marker for susceptibility to a certain behavioural temperament. (nih.gov)
Studies involving corticosterone and levels of stress include impairment of long term memory retrieval, chronic corticosterone elevation due to dietary restrictions and in response to burn injuries. (antibody-antibodies.com)

Corticosterone is the precursor molecule to the mineralocorticoid aldosterone, one of the major homeostatic modulators of sodium and potassium levels in vivo. (wikipedia.org)

Corticosterone both inhibits protein synthesis and degrades proteins. (wikipedia.org)
These findings indicate that Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. (medindia.net)

Anatomy13

Organisms7

Diseases2

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology14

Phenomena and Processes11

Anthropology, Education, Sociology and Social Phenomena2

Health Care2

Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (1/3099)

Maternal adrenocortical hormones maintain the early development of pancreatic B cells in the fetal rat. (2/3099)

The Ca2+ channel blockade changes the behavioral and biochemical effects of immobilization stress. (3/3099)

Relationships between environmental organochlorine contaminant residues, plasma corticosterone concentrations, and intermediary metabolic enzyme activities in Great Lakes herring gull embryos. (4/3099)

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors. (5/3099)

High-temperature effects on antibody response to viral antigen in mice. (6/3099)

Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. (7/3099)

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. (8/3099)

Corticosterone

Adrenocorticotropic Hormone

Adrenalectomy

Pituitary-Adrenal System

Hypothalamo-Hypophyseal System

Restraint, Physical

Adrenal Glands

Stress, Physiological

Metyrapone

Corticotropin-Releasing Hormone

Receptors, Glucocorticoid

Mifepristone

Stress, Psychological

Transcortin

Receptors, Mineralocorticoid

Rats, Sprague-Dawley

Glucocorticoids

Adrenal Cortex

Rats, Wistar

11-beta-Hydroxysteroid Dehydrogenases

Paraventricular Hypothalamic Nucleus

Handling (Psychology)

Behavior, Animal

Steroid 11-beta-Hydroxylase

Hormone Antagonists

Body Weight

Swimming

Aldosterone

Hydroxysteroid Dehydrogenases

11-beta-Hydroxysteroid Dehydrogenase Type 2

Dexamethasone

Circadian Rhythm

Pro-Opiomelanocortin

11-beta-Hydroxysteroid Dehydrogenase Type 1

Hippocampus

Propanil

Hypothalamus

Adrenal Cortex Hormones

Maternal Deprivation

Organ Size

Ether

Drug Implants

Receptors, Corticotropin-Releasing Hormone

Neurosecretory Systems

Analysis of Variance

Desoxycorticosterone

Exploratory Behavior

Crowding

Methylhistidines

Mineralocorticoids

Radioimmunoassay

Hydrocortisone

18-Hydroxycorticosterone

Maze Learning

Immobilization

Hormones

Steroids

Time Factors

Anxiety

Amygdala

Anti-Inflammatory Agents

Cortodoxone

Rats, Inbred Strains

Aldosterone Synthase

Eating

Testosterone

Zona Reticularis

Mice, Inbred C57BL

Zona Fasciculata

Cortisone

Motor Activity

Dose-Response Relationship, Drug

Feathers

RNA, Messenger

Social Isolation

Animals, Newborn

Sparrows

Injections, Intraventricular

Housing, Animal

Solar Activity

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