Coronavirus OC43, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Coronaviridae: Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.Coronavirus, Bovine: A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.Spike Glycoprotein, Coronavirus: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.Coronavirus 229E, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.Nucleocapsid Proteins: Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).SARS Virus: A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.Coronavirus, Feline: A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Coronavirus, Canine: A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.Severe Acute Respiratory Syndrome: A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Murine hepatitis virus: A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).Transmissible gastroenteritis virus: A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.Infectious bronchitis virus: A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Hong Kong: The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.Pneumonia, Viral: Inflammation of the lung parenchyma that is caused by a viral infection.Unedited FootageChina: A country spanning from central Asia to the Pacific Ocean.Police: Agents of the law charged with the responsibility of maintaining and enforcing law and order among the citizenry.Anthropology, Cultural: It is the study of social phenomena which characterize the learned, shared, and transmitted social activities of particular ethnic groups with focus on the causes, consequences, and complexities of human social and cultural variability.Cultural Evolution: The continuous developmental process of a culture from simple to complex forms and from homogeneous to heterogeneous qualities.Ecology: The branch of science concerned with the interrelationship of organisms and their ENVIRONMENT, especially as manifested by natural cycles and rhythms, community development and structure, interactions between different kinds of organisms, geographic distributions, and population alterations. (Webster's, 3d ed)Behaviorism: A psychologic theory, developed by John Broadus Watson, concerned with studying and measuring behaviors that are observable.Social Behavior: Any behavior caused by or affecting another individual, usually of the same species.Behavior: The observable response of a man or animal to a situation.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Patients' Rooms: Rooms occupied by one or more individuals during a stay in a health facility. The concept includes aspects of environment, design, care, or economics.Hospitals, Teaching: Hospitals engaged in educational and research programs, as well as providing medical care to the patients.Internal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.Group Practice: Any group of three or more full-time physicians organized in a legally recognized entity for the provision of health care services, sharing space, equipment, personnel and records for both patient care and business management, and who have a predetermined arrangement for the distribution of income.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Group Practice, Prepaid: An organized group of three or more full-time physicians rendering services for a fixed prepayment.Nigeria: A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.Horse Diseases: Diseases of domestic and wild horses of the species Equus caballus.Togaviridae: A family of RNA viruses, mainly arboviruses, consisting of two genera: ALPHAVIRUS (group A arboviruses), and RUBIVIRUS. Virions are spherical, 60-70 nm in diameter, with a lipoprotein envelope tightly applied to the icosahedral nucleocapsid.Coronavirus, Rat: A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).Sialadenitis: INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries.Viral Nonstructural Proteins: Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.Dacryocystitis: Inflammation of the lacrimal sac. (Dorland, 27th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Viruses: Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Epitopes: Sites on an antigen that interact with specific antibodies.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)History, 17th Century: Time period from 1601 through 1700 of the common era.Societies, Scientific: Societies whose membership is limited to scientists.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.
Acute and persistent infection of human neural cell lines by human coronavirus OC43. (1/49)Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA. (+info)
Pigs with highly prevalent antibodies to human coronavirus and swine haemagglutinating encephalomyelitis virus in the Tohoku District of Japan. (2/49)From 1985 to 1988, a total of 2496 swine sera from 60 farms in the Tohoku District of the Honshu Island of Japan were examined for antibodies to swine haemagglutinating encephalomyelitis virus (HEV), human coronavirus (HCV) and bovine coronavirus (BCV) by haemagglutination-inhibition (HI) test. Antibodies to HEV 67N strain and HCV OC43 strain were highly prevalent with positivity rates of 82.1 and 91.4%, respectively, while seropositivity rate to BCV Kakegawa strain was 44.2%. No clinical signs of HEV infection were noticed in any farms including farms with relatively high seropositivity. The results suggested that HCV or antigenitically related virus(es) as well as HEV might be perpetuated in swine in the Tohoku District. (+info)
Neuroinvasion by human respiratory coronaviruses. (3/49)Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain autopsy samples. Very stringent reverse transcription-PCR with two primer pairs for both viral strains (229E and OC43), combined with Southern hybridization, was performed on samples from 90 coded donors with various neurological diseases (39 with MS and 26 with other neurological diseases) or normal controls (25 patients). We report that 44% (40 of 90) of donors were positive for 229E and that 23% (21 of 90) were positive for OC43. A statistically significant higher prevalence of OC43 in MS patients (35.9%; 14 of 39) than in controls (13.7%; 7 of 51) was observed. Sequencing of nucleocapsid protein (N) gene amplicons revealed point mutations in OC43, some consistently found in three MS patient brains and one normal control but never observed in laboratory viruses. In situ hybridization confirmed the presence of viral RNA in brain parenchyma, outside blood vessels. The presence of HCoV in human brains is consistent with neuroinvasion by these respiratory pathogens. Further studies are needed to distinguish between opportunistic and disease-associated viral presence in human brains. (+info)
Characterization of a coronavirus isolated from a diarrheic foal. (4/49)A coronavirus was isolated from feces of a diarrheic foal and serially propagated in human rectal adenocarcinoma (HRT-18) cells. Antigenic and genomic characterizations of the virus (isolate NC99) were based on serological comparison with other avian and mammalian coronaviruses and sequence analysis of the nucleocapsid (N) protein gene. Indirect fluorescent-antibody assay procedures and virus neutralization assays demonstrated a close antigenic relationship with bovine coronavirus (BCV) and porcine hemagglutinating encephalomyelitis virus (mammalian group 2 coronaviruses). Using previously described BCV primers, the N protein gene of isolate NC99 was amplified by a reverse transcriptase PCR (RT-PCR) procedure. The RT-PCR product was cloned into pUC19 and sequenced; the complete N protein of NC99 (446 amino acids) was then compared with published N protein sequences of other avian and mammalian coronaviruses. A high degree of identity (89.0 to 90.1%) was observed between the N protein sequence of NC99 and published sequences of BCV (Mebus and F15 strains) and human coronavirus (strain OC43); only limited identity (<25%) was observed with group 1 and group 3 coronaviruses. Based on these findings, the virus has been tentatively identified as equine coronavirus (ECV). ECV NC99 was determined to have close antigenic and/or genetic relationships with mammalian group 2 coronaviruses, thus identifying it as a member of this coronavirus antigenic group. (+info)
Vacuolating encephalitis in mice infected by human coronavirus OC43. (5/49)Involvement of viruses in human neurodegenerative diseases and the underlying pathologic mechanisms remain generally unclear. Human respiratory coronaviruses (HCoV) can infect neural cells, persist in human brain, and activate myelin-reactive T cells. As a means of understanding the human infection, we characterized in vivo the neurotropic and neuroinvasive properties of HCoV-OC43 through the development of an experimental animal model. Virus inoculation of 21-day postnatal C57BL/6 and BALB/c mice led to a generalized infection of the whole CNS, demonstrating HCoV-OC43 neuroinvasiveness and neurovirulence. This acute infection targeted neurons, which underwent vacuolation and degeneration while infected regions presented strong microglial reactivity and inflammatory reactions. Damage to the CNS was not immunologically mediated and microglial reactivity was instead a consequence of direct virus-mediated neuronal injury. Although this acute encephalitis appears generally similar to that induced by murine coronaviruses, an important difference rests in the prominent spongiform-like degeneration that could trigger neuropathology in surviving animals. (+info)
Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction. (6/49)During the past years, human coronaviruses (HCoVs) have been increasingly identified as pathogens associated with more-severe respiratory tract infection (RTI). Diagnostic tests for HCoVs are not frequently used in the routine setting. It is likely that, as a result, the precise role that HCoVs play in RTIs is greatly underestimated. We describe a rapid, sensitive, and highly specific quantitative real-time reverse-transcriptase polymerase chain reaction (RT-PCR) for the detection of HCoV that can easily be implemented in the routine diagnostic setting. HCoV was detected in 28 (11%) of the 261 clinical specimens obtained from patients presenting with symptoms of RTI ranging from common cold to severe pneumonia. Only 1 (0.4%) of the 243 control specimens obtained from patients without symptoms of RTI showed the presence of HCoV. We conclude that HCoVs can be frequently detected in patients presenting with RTI. Real-time RT-PCR provides a tool for large-scale epidemiological studies to further clarify the role that coronavirus infection plays in RTI in humans. (+info)
Human respiratory coronavirus OC43: genetic stability and neuroinvasion. (7/49)The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained. Both genomes are 30,713 nucleotides long, excluding the poly(A) tail, and only differ by 6 nucleotides. These six mutations are scattered throughout the genome and give rise to only two amino acid substitutions: one in the spike protein gene (I958F) and the other in the nucleocapsid protein gene (V81A). Furthermore, the two variants were shown to reach the central nervous system (CNS) after intranasal inoculation in BALB/c mice, demonstrating neuroinvasive properties. Even though the ATCC strain could penetrate the CNS more effectively than the Paris 2001 isolate, these results suggest that intrinsic neuroinvasive properties already existed for the HCoV-OC43 ATCC human respiratory isolate from the 1960s before it was propagated in newborn mouse brains. It also demonstrates that the molecular structure of HCoV-OC43 is very stable in the environment (the two variants were isolated ca. 40 years apart) despite virus shedding and chances of persistence in the host. The genomes of the two HCoV-OC43 variants display 71, 53.1, and 51.2% identity with those of mouse hepatitis virus A59, severe acute respiratory syndrome human coronavirus Tor2 strain (SARS-HCoV Tor2), and human coronavirus 229E (HCoV-229E), respectively. HCoV-OC43 also possesses well-conserved motifs with regard to the genome sequence of the SARS-HCoV Tor2, especially in open reading frame 1b. These results suggest that HCoV-OC43 and SARS-HCoV may share several important functional properties and that HCoV-OC43 may be used as a model to study the biology of SARS-HCoV without the need for level three biological facilities. (+info)
Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. (8/49)Coronaviruses are enveloped, positive-stranded RNA viruses with a genome of approximately 30 kb. Based on genetic similarities, coronaviruses are classified into three groups. Two group 2 coronaviruses, human coronavirus OC43 (HCoV-OC43) and bovine coronavirus (BCoV), show remarkable antigenic and genetic similarities. In this study, we report the first complete genome sequence (30,738 nucleotides) of the prototype HCoV-OC43 strain (ATCC VR759). Complete genome and open reading frame (ORF) analyses were performed in comparison to the BCoV genome. In the region between the spike and membrane protein genes, a 290-nucleotide deletion is present, corresponding to the absence of BCoV ORFs ns4.9 and ns4.8. Nucleotide and amino acid similarity percentages were determined for the major HCoV-OC43 ORFs and for those of other group 2 coronaviruses. The highest degree of similarity is demonstrated between HCoV-OC43 and BCoV in all ORFs with the exception of the E gene. Molecular clock analysis of the spike gene sequences of BCoV and HCoV-OC43 suggests a relatively recent zoonotic transmission event and dates their most recent common ancestor to around 1890. An evolutionary rate in the order of 4 x 10(-4) nucleotide changes per site per year was estimated. This is the first animal-human zoonotic pair of coronaviruses that can be analyzed in order to gain insights into the processes of adaptation of a nonhuman coronavirus to a human host, which is important for understanding the interspecies transmission events that led to the origin of the severe acute respiratory syndrome outbreak. (+info)
Human coronavirus OC43
... is an enveloped, positive-stranded RNA virus in the species Betacoronavirus-1 (genus Betacoronavirus, ... "Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a ... Van Der Hoek, L (2007). "Human coronaviruses: What do they cause?". Antiviral Therapyapy. 12 (4 Pt B): 651-8. PMID 17944272. ... ISBN 978-1-55581-371-0. Pyrc, K.; Berkhout, B.; Van Der Hoek, L. (2007). "Antiviral Strategies Against Human Coronaviruses". ...
Human coronavirus 229E Human coronavirus OC43 SARS-CoV Human Coronavirus NL63 (HCoV-NL63, New Haven coronavirus) Human ... Bovine coronavirus and human coronavirus OC43 diverged in 1899. Bovine coronavirus diverged from the equine coronavirus species ... Another estimate suggests that human coronavirus OC43 diverged from bovine coronavirus in 1890. The MRCA of human coronavirus ... These viruses were subsequently named human coronavirus 229E and human coronavirus OC43. Coronaviruses primarily infect the ...
Human coronavirus 229E
Along with Human coronavirus OC43, it is responsible for the common cold. HCoV-229E transmits via droplet-respiration and ... Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a ... Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using ... Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients. J. Clin. Virol. 38:244 ...
Indirect immunoperoxidase assay
These viruses include human coronavirus 229E and OC43. Susceptible cells are inoculated with serial logarithmic dilutions of ... "Titration of Human Coronaviruses, HCoV-229E and HCoV-OC43, by an Indirect Immunoperoxidase Assay". SARS- and Other ... This technique is a reliable method for the titration of human coronaviruses (HCoV) in biological samples (cells, tissues, or ... Lambert, Francine; Jacomy, Helene; Marceau, Gabriel; Talbot, Pierre J. (28 April 2008). "Titration of Human Coronaviruses Using ...
Animal viruses Human coronavirus HKU1 Human coronavirus OC43 MERS-CoV Pipistrellus Bat coronavirus HKU5 RNA virus SARS-CoV ... The Beta-CoVs of the greatest clinical importance concerning humans are OC43, and HKU1 of the A lineage, SARS-CoV of the B ... MERS-CoV is the first betacoronavirus belonging to lineage C that is known to infect humans. The alpha- and beta-coronavirus ... Pipistrellus bat coronavirus HKU5 (BtCoV-HKU5), and MERS-CoV (various species) Lineage D includes Rousettus bat coronavirus ...
Tylonycteris bat coronavirus HKU4
Severe acute respiratory syndrome Tylonycteris Pipistrellus Human coronavirus HKU1 Human coronavirus OC43 Pipistrellus Bat ... relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus ... Tylonycteris bat coronavirus HKU4 (Bat-CoV HKU4) is an enveloped, positive sense, single-stranded RNA mammalian Group 2 ... The exact means of transmission to humans is not yet well known. However, it has been demonstrated that betaCoV's including ...
Middle East respiratory syndrome coronavirus
... commonly called Human coronavirus OC43), Human coronavirus HKU1, Murine coronavirus, Pipistrellus bat coronavirus HKU5, ... Lau SK, Lee P, Tsang AK, Yip CC, Tse H, Lee RA, Molecular epidemiology of human coronavirus OC43 reveals evolution of different ... Severe acute respiratory syndrome coronavirus Other names: novel coronavirus (nCoV) London1 novel CoV/2012 Human Coronavirus ... from SARS coronavirus and distinct from the common-cold coronavirus and known endemic human betacoronaviruses HCoV-OC43 and ...
Rousettus bat coronavirus HKU9
Severe acute respiratory syndrome Tylonycteris Pipistrellus Human coronavirus HKU1 Human coronavirus OC43 Pipistrellus Bat ... This strain of coronavirus is closely related to the newly identified novel EMC/2012 strain found in London which is related to ... Human Betacoronavirus 2c EMC/2012-related Viruses in Bats, Ghana and Europe. Dispatch. Volume 19, Number 3-March 2013. Patrick ... Rousettus bat coronavirus HKU9 (Bat-CoV HKU9) is an enveloped, positive-sense, single-stranded RNA mammalian Group 2 ...
Human coronavirus HKU1
... and is distinct in that regard from the only other known group 2 human coronavirus, HCoV-OC43. When the RNA-dependent RNA ... Sloots, T; McErlean, P; Speicher, D; Arden, K; Nissen, M; MacKay, I (2006). "Evidence of human coronavirus HKU1 and human ... Coronavirus Mouse hepatitis virus Murinae Tylonycteris bat coronavirus HKU4 Rousettus bat coronavirus HKU9 Lau, S. K. P.; Woo, ... Human coronavirus HKU1 (HCoV-HKU1) is a positive-sense, single-stranded RNA virus with the HE gene, which distinguishes it as a ...
2012 Middle East respiratory syndrome coronavirus outbreak
In the article, they noted four respiratory human coronaviruses (HCoV) known to be endemic: 229E, OC43, NL63, and HKU1. In May ... Most infections with human coronaviruses are mild and associated with common colds. The six coronaviruses known to infect ... Lu, Guangwen; Liu, Di (2012). "SARS-like virus in the Middle East: A truly bat-related coronavirus causing human diseases" (PDF ... Zaki and co-authors from the Erasmus Medical Center published more details, including a scientific name, Human Coronavirus- ...
Known as canine respiratory coronavirus (CRCoV) and found to be similar to strain OC43 of bovine and human coronaviruses, it ... A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus ... Canine coronavirus is a virus of the family Coronaviridae that causes a highly contagious intestinal disease worldwide in dogs ... Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be ...
Avian coronavirus Species: Avian coronavirus, Beluga whale coronavirus SW1 Coronavirus RNA virus Human coronavirus OC43 Human ... Human coronavirus 229E, Human Coronavirus NL63, Miniopterus Bat coronavirus 1, Miniopterus Bat coronavirus HKU8, Porcine ... Human coronavirus HKU1, Murine coronavirus, Pipistrellus Bat coronavirus HKU5, Rousettus Bat coronavirus HKU9, Severe acute ... HCoV-OC43 Genus Deltacoronavirus; type species: Bulbul coronavirus HKU11 Species: Bulbul coronavirus HKU11, Munia coronavirus ...
Human coronavirus NL63
... suggesting that it is a common cold virus similar to HCoV-229E and HCoV-OC43, which generally cause less severe symptoms. ... Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child ... Public Health Agency of Canada "Human Coronavirus" Retrieved on July 22, 2015. Center for Disease Control "About Coronavirus" ... Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad ...
List of MeSH codes (B04)
... coronavirus 229e, human MeSH B04.820.504.540.150.220 --- coronavirus oc43, human MeSH B04.820.504.540.150.260 --- coronavirus, ... human MeSH B04.909.777.500.540.150.220 --- coronavirus oc43, human MeSH B04.909.777.500.540.150.260 --- coronavirus, rat MeSH ... human MeSH B04.820.565.284.182 --- enterovirus b, human MeSH B04.820.565.284.182.225 --- echovirus 6, human MeSH B04.820. ... human MeSH B04.909.777.618.284.182 --- enterovirus b, human MeSH B04.909.777.618.284.182.225 --- echovirus 6, human MeSH ...
Middle East respiratory syndrome
... a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the ... method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well ... 2012). "SARS-like virus in the Middle East: A truly bat-related coronavirus causing human diseases" (PDF). Protein & Cell. 3 ( ... Zaki and co-authors from the Erasmus Medical Center published more details, including a tentative name, Human Coronavirus- ...
Before the SARS outbreak only two human coronaviruses (HCoV) were known: HCoV-OC43 and HCoV-229E. With the discovery of SARS-CoV in 2003, a third family member ...
Earnings for engineers vary significantly by specialty. Even so, as a gaggle engineers earn some of the highest average beginning salaries among these holding
THE AMAZING JOHNATHAN AT BREA IMPROV, 120 S. BREA BLVD., BREA, (714) 482-0700; BREAIMPROV.COM. FRI., 7:30 AND 9:45 P.M.; SAT., 7 AND 9:15 P.M.; SUN., 7...
Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants | Archives of Disease in Childhood
Objective: To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection.. Methods: 182 infants aged ,12 months hospitalised for bronchiolitis were enrolled. Infants underwent nasal washing for the detection of RSV, influenza virus A and B, human coronavirus OC43, 229E, NL-63, HUK1, adenovirus, RV, parainfluenza 1-3, human metapneumovirus and hBoV. Demographic, clinical and laboratory data were obtained from parents and from patient medical files. Main outcome measurements were age, breastfeeding history, family smoking habits, family history for asthma and atopy, blood eosinophil count, chest radiological findings, clinical severity score and number of days of hospitalisation.. Results: A virus was detected in 57.2% of the 182 infants. The most frequently detected viruses were RSV (41.2%), hBoV (12.2%) and RV (8.8%). Infants with ...
Human coronavirus. Coloured transmission electron micrograph (TEM) of Human coronavirus particles (purple circles). Coronaviruses primarily infect the upper respiratory and gastrointestinal tract and can cause the common cold, gastrointestinal infections and SARS (severe acute respiratory syndrome). Coronaviruses are named after the corona (crown) of surface proteins (dark dots) that are used to penetrate a host cell. Once inside the cell, the virus particles (virions) use the cells machinery to make more copies of themselves. Magnification: x67,000 when printed 10 centimetres tall. - Stock Image C001/0467
Recombinant Human coronavirus SARS Nucleoprotein is an Escherichia coli Protein fragment 1 to 49 aa range, | 95% purity and validated in WB, ELISA, SDS-PAGE.
Get PDF - The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
Poppe, M.; Wittig, S.; Jurida, L.; Bartkuhn, M.; Wilhelm, J.; Müller, H.; Beuerlein, K.; Karl, N.; Bhuju, S.; Ziebuhr, J.; Schmitz, M.Lienhard.; Kracht, M., 2017: The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
Data from: Etiology of respiratory tract infections in the community and clinic in Ilorin, Nigeria - Dryad
Objective: Recognizing increasing interest in community disease surveillance globally, the goal of this study was to investigate whether respiratory viruses circulating in the community may be represented through clinical (hospital) surveillance in Nigeria. Results: Children were selected via convenience sampling from communities and a tertiary care center (n = 91) during spring 2017 in Ilorin, Nigeria. Nasal swabs were collected and tested using polymerase chain reaction. The majority (79.1%) of subjects were under 6 years old, of whom 46 were infected (63.9%). A total of 33 of the 91 subjects had one or more respiratory tract virus; there were 10 cases of triple infection and 5 of quadruple. Parainfluenza virus 4, respiratory syncytial virus B and enterovirus were the most common viruses in the clinical sample; present in 93.8% (15/16) of clinical subjects, and 6.7% (5/75) of community subjects (significant difference, p , 0.001). Coronavirus OC43 was the most common virus detected in ...
Human coronaviruses (HCV) cause various respiratory, gastrointestinal and possibly neurological disorders. Very little is known of the molecular biology of these ubiquitous pathogens. We have...
Coronaviruses were classified as a distinct group of viruses in 19681 and are now recognized as the etiologic agents of an increasing number of diseases of man and animals2-7. At least four members...
In deze video, tonen we een alternatieve methode voor de detectie en titering van virussen met behulp van een enzymatische antigeen...
Recapitulating Amyloid β and Tau Pathology in Human Neural Cell Culture Models-Clinical Implications | touchNEUROLOGY | Leading...
Alzheimers disease (AD) is the most common neurodegenerative disease, clinically characterized by progressive memory loss. To date, an estimated 5.2 million people have the disease in the US, and the total number of people with AD-related dementia is projected to rise to 13.8 million by 2050.1,2 At present, there is no cure for the disease, and early clinical diagnosis is not yet available for the majority of patients.
Eysteinn konvngr hafþi vistir sinar i Þrandheimi vm vetrinn. oc vm svmarit eptir gerþi hvarrtveggi konvnga orþ sinom monnom. beði lendom monnom oc handgengnom. at þeir scylldo fiolmenna til þings. Olafr konvngr broþir þeira var a lifi þa er þetta var. oc var honom oc stefnt til þings með sina menn. Eysteinn konvngr var firir i bønom er at sotti þingino. oc hafþi vistir sinar i konvngsgarþi. Olafr konvngr com fyrri en Sigurþr konvngr oc hafþi vistir sinar i bønom scamt fra Olafs kirkio. Sigurþr konvngr com siþarst með scipaliþi miclo. oc lagþi scipin í ana Nið. oc byggia a scipom vndir tioldom oc hofþo allmikit lið. Oc þann dag er þeir scylldo þingit heyia. þa var blasit i bønom at bendr i bønom oc þingonavtar scylldo fyrst ganga a þingit oc scipa domvm eptir logom. var þar mest firemaðr Joan mornefs son faþir Einriða er fell vndir Serc lendr maþr oc gofvgr. Þar var með Olafi konvngi Sigvrðr Sigurþar son af Hvitvasteini sa lendr maþr er einna ...
In an accompanying editorial, Kenneth McIntosh of Harvard University commented that discovery of a new human respiratory coronavirus would not be surprising, since studies in the 1960s and 1970s had pointed to a number of novel coronavirus strains but the findings were not adequately followed up because methods to do so were unavailable at the time. The statistically strong association with Kawasaki disease, however, was "quite surprising." Noting that previous attempts to link Kawasaki disease to bacteria or other viruses had failed and thus justified healthy skepticism about the present findings, Dr. McIntosh pointed out some "tantalizing facts": onset of Kawasaki disease is often preceded by a respiratory syndrome; both the disease and respiratory coronavirus infections are seasonal, peaking in the winter and spring; recent studies have described a powerful immune response in the respiratory tract and other organs in acute cases of Kawasaki disease, suggesting the involvement of a specific ...
The SARS epidemic of 2002-2003 was short-lived, but a novel type of human coronavirus that is alarming public health authorities can infect cells from humans and bats alike, a fact that could make the animals a continuing ...
The SARS epidemic of 2002-2003 was short-lived, but a novel type of human coronavirus that is alarming public health authorities can infect cells from humans and bats alike, a fact that could make the animals a continuing source of infection, according to a study to be published in in mBio®, the online open-access journal of the American Society for Microbiology, on December 11. The new cor
MUC16小鼠单克隆抗体[OC125](ab693)可与人样本反应并经IHC, Flow Cyt实验严格验证，被9篇文献引用。所有产品均提供质保服务，中国75%以上现货。
ഒരു കാർബണിക സംയുക്തമാണ് അക്രിലോനൈട്രൈൽ. ഇതിനു വിനൈൽ സയനൈഡ് എന്നും പേരുണ്ട്. ദ്രവവസ്തുവാണ്. ഫോർമുല, CH2=CH-CN. തിളനില 78oC വെള്ളത്തിൽ അലിയും. ആ.സാ. 0.797. ബേരിയം സയനൈഡിന്റെ സാന്നിധ്യത്തിൽ അസറ്റിലീൻ ഹൈഡ്രജൻ സയനൈഡുമായി പ്രവർത്തിച്ചു അക്രിലൊനൈട്രൈൽ ലഭ്യമാക്കുന്നു:. CH = CH + HCN → CH2 = CH - CN. അക്രിലൊനൈട്രൈൽ സ്വയം പോളിമറീകരിച്ചും മറ്റു യൗഗികങ്ങളുമായി സഹപോളിമറീകരിച്ചും (copolymerise) വ്യവസായപ്രാധാന്യമുള്ള ...
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The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome...
Using the purified proteins as antigens in ELISA assays for antibodies in the sera of SARS patients we found that the assay using truncated S-N fusion protein has a clearly higher sensitivity than those using intact N protein or truncated S and N proteins, and virtually as high as the assay using whole SARSCoV lysate (Table 2). The results indicated the N and S protein were complementary in detecting SARS-specific antibodies. This is consistent with previous studies [28, 29]. Five positive sera to SARSCoV lysate antigen were all tested positive against SARSCoV N protein but negative against SARSCoV truncated N-S protein. These sera were also tested positive against N proteins of HCoV 229E and HCoV OC43 (data not shown), which could be reasonably explained partly by existence of other HCoV infections in these humans. The truncated S-N fusion protein was also subjected to ELISA with mice antisera against SARSCoV (BJ01), HCoV 229E and HCoV OC43. Only mice antiserum against SARSCoV(BJ01) tests ...
Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort | Thorax
Healthy children in the ORChID community-based birth cohort experienced an incidence rate of 978 new VDEs per 100 child-years during the first 2 years of life, with HRV playing a dominant role. Overall, respiratory viruses were detected by PCR in regular weekly swabs at least once during 75% of ARIs, while in asymptomatic periods 23% of weekly nasal swabs were positive by PCR for respiratory viruses, accounting for 33% of all new VDEs. We demonstrated evidence of attribution for ARIs by RNA viruses, which included HRV (HRV-A, HRV-C), influenza (IFV-A), parainfluenza (PIV-1, PIV-3), RSV (RSV-A, RSV-B), HCoV (HCoV-OC43, HCoV-NL63) and HMPV; and AdV as the single DNA virus representative. All these viruses were detected significantly more often in children with an ARI than during asymptomatic periods and had statistically significant positive AFEs. The largest association was observed for RSV and HMPV, both of which were more strongly associated with LRTIs than other respiratory viruses. Increasing ...
NCAM1 - NCAM1 (Myc-DDK-tagged)-Human neural cell adhesion molecule 1 (NCAM1), transcript variant 2 available for purchase from OriGene - Your Gene Company.
A2018016122500.L2_LAC_OC.nc, A2018016123000.L2_LAC_OC.nc, A2018016134000.L2_LAC_OC.nc, A2018016134500.L2_LAC_OC.nc, A2018016135000.L2_LAC_OC.nc, A2018016135500.L2_LAC_OC.nc, A2018016140000.L2_LAC_OC.nc, A2018016152000.L2_LAC_OC.nc, A2018016153000.L2_LAC_OC.nc, A2018016153500.L2_LAC_OC.nc, A2018016154000.L2_LAC_OC.nc, A2018016154500.L2_LAC_OC.nc, A2018016170000.L2_LAC_OC.nc, A2018016170500.L2_LAC_OC.nc, A2018016171000.L2_LAC_OC.nc, A2018016171500.L2_LAC_OC.nc, A2018016172000.L2_LAC_OC.nc, A2018016172500.L2_LAC_OC.nc, A2018016183500.L2_LAC_OC.nc, A2018016184000.L2_LAC_OC.nc, A2018016184500.L2_LAC_OC.nc, A2018016185000.L2_LAC_OC.nc, A2018016185500.L2_LAC_OC.nc, A2018016190000.L2_LAC_OC.nc, A2018016190500.L2_LAC_OC.nc, A2018016201500.L2_LAC_OC.nc, A2018016202000.L2_LAC_OC.nc, A2018016202500.L2_LAC_OC.nc, A2018016203000.L2_LAC_OC.nc, A2018016204000.L2_LAC_OC.nc, A2018016215500.L2_LAC_OC.nc, A2018016220000.L2_LAC_OC.nc, A2018016220500.L2_LAC_OC.nc, A2018016221000.L2_LAC_OC.nc, ...
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HUMAN coronaviruses (HCV) in two serogroups represented by HCV-229E and HCV-OC43 are an important cause of upper respiratory tract infections1. Here we report that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells2-5, is a receptor for human coronavirus strain HCV-229E, but not for HCV-OC43. A monoclonal antibody, RBS, blocked HCV-229E virus infection of human lung fibroblasts, immunoprecipitated aminopeptidase N and inhibited its enzymatic activity. HCV-229E-resistant murine fibroblasts became susceptible after transfection with complementary DNA encoding human aminopeptidase N. By contrast, infection of human cells with HCV-OC43 was not inhibited by antibody RBS and expression of aminopeptidase N did not enhance HCV-OC43 replication in mouse cells. A mutant aminopeptidase lacking the catalytic site of the enzyme did not bind HCV-229E or RBS and did not render murine cells susceptible to HCV-229E infection, suggesting that the virus-binding site may
Wu, C.Y., Jan, J.T., Ma, S.H., Kuo, C.J., Juan, H.F., Cheng, Y.S.E. , Hsu, H.H., Huang, H.C., Wu, D., Brik, A., Liang, F.S., Liu, R.S., Fang, J.M. , Chen, S.T., Liang, P.H. , and Wong, C.H. . Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci USA 2004, 101, 10012-10017 ...
Definition of OC3 in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is OC3? Meaning of OC3 as a finance term. What does OC3 mean in finance?
Page contains details about YD2-oC8-sensitized TiO2 film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
WSR 06-15-075, recodified as § 170-295-5140, filed 7/13/06, effective 7/13/06. Statutory Authority: Chapters 74.12 and 74.15 RCW. WSR 03-14-110, § 388-295-5140, filed 6/30/03, effective 8/1/03 ...
Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which do not target the underlying virus infection. The identification of specific inhibitors of coronaviruses or knowledge about how coronaviruses interact with the innate immune system could provide new avenues for developing therapeutics. I investigated the replication of human coronavirus NL63 (HCoV-NL63) in primary human airway epithelial cultures and characterized the activity of the viral papain-like protease 2 (PLP2) domain. Using quantitative real time PCR and imaging techniques I showed that HCoV-NL63
Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child with bronchiolitis in the Netherlands. Infection with the virus has been confirmed worldwide, and has an association with many common symptoms and diseases. Associated diseases include mild to moderate upper respiratory tract infections, severe lower respiratory tract infection, croup and bronchiolitis. The virus is found primarily in young children, the elderly, and immunocompromised patients with acute respiratory illness. It also has a seasonal association in temperate climates. A study performed in Amsterdam estimated the presence of HCoV-NL63 in approximately 4.7% of common respiratory illnesses. Further studies confirmed that the virus is not an emerging virus, but rather one that continually circulates the human population. The first cases of the infection with HCoV-NL63 were found in young children with severe lower respiratory tract infections admitted to ...
TY - JOUR. T1 - History and recent advances in coronavirus discovery. AU - Kahn, Jeffrey. AU - McIntosh, Kenneth. PY - 2005/11. Y1 - 2005/11. N2 - Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history ...
Anti-coronaravirus antibodies are present in most people but reinfection is common. This indicates that there are many circulating serotypes of of the virus in the human population. So far, animal reservoirs have not been found for those viruses that infect humans. Cornavirus causes cold more often in the winter, as is typical with most respiratory infections, because of closer contact. Major outbreaks occur every few years with a cycle that depends on the type of virus that is involved. The human coronaviruses are responsible for 10-20% of all common colds and have been implicated in gastroenteritis, high and low respiratory tract infections and rare cases of encephalitis. The symptoms of coronavirus colds are similar to those of rhinovirus colds which include runny nose, sore throat, cough, headache, fever and chills. The incubation period is about 3 days. The immune response of most patients limits the viral spread but this immunity is short-lived. Although it varies considerably between ...
|strong|Mouse anti Bovine Coronavirus Surface Antigen antibody, clone 5A4|/strong| recognizes the surface antigen of bovine coronavirus. Bovine coronavirus (BCoV) causes severe diarrhoea in newborn ca…
Download Biochemistry and Biology of Coronaviruses by Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. PDF - Barbara...
By Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.). This e-book is the results of a global symposium held on the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The purpose of this symposium was once to supply a chance to check the information on coronavirus constitution and duplicate- tion in addition to to debate mechanisms of pathogenesis. For over a decade coronaviruses were famous as a big staff of viruses that are chargeable for quite a few ailments of medical significance in animals and guy. lately new and fascinating information at the molecular biology and pathogenesis of coronaviruses became to be had and this led us to arrange this assembly. The uniformity and variety during this virus staff used to be evaluated from a molecular standpoint and the replication of coronaviruses seems to be to contain features that could be particular for this virus staff. also, not like different confident strand RNA viruses it grew ...
Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimers Disease To investigate the role of the cerebral vasculature in Alzheimers disease, a physiologically relevant 3D human neural cell culture microfluidic model was developed having a brain endothelial cell monolayer with a blood-brain barrier-like phenotype. [Adv Sci] Full Article , Press Release CAF Hierarchy Driven by Pancreatic Cancer Cell p53-Status Creates a Pro-Metastatic and Chemoresistant Environment via Perlecan Scientists revealed the existence of a p53-driven hierarchy, where cancer cells with a gain-of-function (GOF) mutant p53 educated a dominant population of cancer-associated fibroblasts (CAFs) that established a pro-metastatic environment for GOF and null p53 cancer cells alike. [Nat Commun] Full Article , Press Release High Stretchability, Strength, and Toughness of Living Cells Enabled by Hyperelastic Vimentin Intermediate Filaments The authors identified that cytoskeletal vimentin intermediate filaments ...
The SARS-coronavirus (SARS-CoV) is a newly emerged, highly pathogenic agent that caused over 8,000 human infections with nearly 800 deaths between …
Science writer David Quammen says the new coronavirus is the latest example of the way pathogens are migrating from animals to humans with increasing frequency - and sometimes deadly consequences.
16. A compound of formula (I) or a pharmaceutically acceptable salt thereof ##STR00198## wherein:A is selected from mono- and bicyclic aryl, mono- and bicyclic heteroaryl, cycloalkenyl and mono- and bicyclic heterocyclyl;R1 is independently selected from halogen, nitro, SF5, CHO, C0-6alkylCN, OC1-6alkylCN, C0-6alkylOR5, OC2-6alkylOR5, C0-6alkylNR5R6, OC2-6alkylNR5R6, OC2-6alkylOC2-6alkylNR5R6, C0-6alkylCO2R5, OC1-6alkylCO2R5, C0-6alkylCON(R5)2, OC1-6alkylCON(R5)2, OC2-6alkylNR5(CO)R6, C0-6alkylNR5(CO)R6, O(CO)NR5R6, NR5(CO)OR6, NR5(CO)NR5R6, O(CO)OR5, O(CO)R5, C0-6alkylCOR5, OC1-6alkylCOR5, NR5(CO)(CO)R5, NR5(CO)(CO)NR5R6, C0-6alkylSR5, C0-6alkyl(SO2)NR5R6, OC1-6alkylNR5(SO2)R6, OC0-6alkyl(SO2)NR5R6, C0-6alkyl(SO)NR5R6, OC1-6alkyl(SO)NR5R6, C0-6alkylOSO2R5, C0-6alkylNR5(SO2)NR5R6, C0-6alkylNR5(SO)R6, OC2-6alkylNR5(SO)R6, OC1-6alkylSO2R5, C0-6alkylSO2R5, C0-6alkylSOR5, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3-8cycloalkyl, C0-6alkylaryl, C0-6alkylheteroaryl and C0-6alkylheterocyclyl, ...
Information from WorldCat about Observatoire océanologique in Banyuls-sur-Mer CEDEX, , such as address, phone, catalog search and newest items.
If the fanciest thing youve ever driven is a 1999 Toyota Camry, its easy to not think about Crevier Classic Cars. But its stunning showroom of automot...
Not to feed the trolls here, but I am more interested in how well they overclock using conventionally available cooling (and with more moderate vcore...
i need to overclock this system: elitegroup C51GM-M nvidia 7600gt oc 256mb pci-e amd 4800+ 2.5 dual core Maxtor 200 gig sata-II harddrivew/Vantec
Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Get PDF - Detection of group 1 coronaviruses in bats using universal coronavirus reverse transcription polymerase chain...
Poon, L.L.M.; Peiris, J.S.Malik., 2008: Detection of group 1 coronaviruses in bats using universal coronavirus reverse transcription polymerase chain reactions
CORONAVIRUS has now infected more than 5,000 people in the UK, killed thousands around the world and infected a total of more than 200,000 patients. But how many people have recovered from coronavirus?
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many people will get infected or sick during this outbreak. most coronavirus infections will either have no symptoms or mild symptoms consistent with the flu.
A virus is a microscopic parasite that cannot live or reproduce outside of a host body. A "host" refers to the organism or species (like humans, dogs or cats) that a virus is able to infect. Viruses, which are much smaller than the cells that make up our bodies, move between cells and infect them individually, and use cells to create copies of themselves.. Coronavirus is one type of virus much like a banana is one type of fruit. There are many types of viruses that infect different parts of the body. An intestinal virus, for example can cause vomiting, diarrhea and inappetence (not wanting to eat). Coronavirus is a respiratory virus (in humans) because it infects the cells of the respiratory tract (nasal passages, bronchi, bronchioles, and lung tissue) and causes respiratory symptoms such as coughing, runny nose, sneezing and sore throat.. ...
We've been flooded with thousands of reader questions on coronavirus. We're answering them. - News - Wilmington Star News -...
As the coronavirus pandemic continues to shut down daily life across the globe, thousands of our readers across the nation have asked us questions about COVID-19.And were answering them.For basic facts about the virus - what it is, how it spreads and where its located - you can get caught up by reading our in-depth explainer here. Weve also debunked some viral coronavirus myths. But youre curious and continue to ask important
Read more on what we know about COVID-19 coronavirus, including how contagious and dangerous it is, and how to prevent from becoming infected with coronavirus.
Often marked by fever, vomiting and loss of appetite, coronavirus in dogs is caused by a virus. Heres need-to-know information on helping your pet heal.
Im very concerned about my elderly mother catching the coronavirus (COVID-19). Is she at more of a risk for the illness and if so, what can we do to protect her?
Overwhelmed laboratories have been unable to process coronavirus tests when promised, leaving many Rochesterians in virus-testing limbo.
ProMach Coronavirus (COVID-19) Update - we remain committed to helping our customers keep their packaging lines operating as efficiently as possible while focusing on the safety and protection of everyone.
We know there is a growing concern regarding the impact of the coronavirus, and wed like to inform you that we have taken all the right measures and precautions for our team
Streets are empty in various cities across the globe as countries close schools, shops, public places, and put cities on lockdown to fight the new coronavirus pandemic.
Hey everyone, This is a megathread for anything related to coronavirus that is **nonpolitical** and **not about asktrumpsupporters itself**....
Stay tuned as Patient Power provides the latest news on the coronavirus outbreak with updates from renowned doctors, researchers and experts to help keep cancer patients and their loved ones informed and safe.
As spread of the novel COVID-19 coronavirus continues, the American College of Cardiology has released a clinical update that looks at early cardiac implications and clinical guidance.
Bans on birthing partners amid coronavirus 'perhaps necessary' at hard-hit hospitals, Dr. Manny Alvarez says | TuronZamin
Get all the latest news on coronavirus and more delivered daily to your inbox. Sign up here.As several hospitals shift to ban spouses and birthing partners from…
The number of people in intensive care units (ICU) for coronavirus infection in France fell slightly for the first time since the start of the epidemic, but the number of people dying in nursing homes jumped by more than 50 percent over two days, health m... ...
Experts see two scenarios: 2019-nCoV becomes like the four little-known coronaviruses already endemic in people, or it becomes like the seasonal flu.
Coronaviruses are zoonotic, which means they?re known to be transmitted between animals and people. Coronaviruses are part of a large family of viruses; the illnesses these viruses cause (like COVID-19) range from mild to serious. Here are the signs and symptoms of COVID-19 you need to look out for.
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The total number of tests alone does not tell the real story. Here are some of the measures that you should be looking at to better understand how the U.S. doing.
q1p302key - CH302 TA Practice Quiz 1 Answer Key 1 An unknown liquid is 2000 Pa at 25 oC and 7500 Pa at 50 oC Based on the...
View Notes - q1p302key from CH 302 at University of Texas. CH302 TA Practice Quiz 1 Answer Key 1. An unknown liquid is 2000 Pa at 25 oC and 7500 Pa at 50 oC. Based on the ClausiusClapeyron equation
Océan-class ship of the line: | | | ||| | 1/48 scale model of the |Océan| class 1... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
For scientists conducting SARS research, ATCC offers coronaviruses from a range of species and the cell lines needed to cultivate them.
For scientists conducting SARS research, ATCC offers coronaviruses from a range of species and the cell lines needed to cultivate them.
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AMD launched new APU structure, FM1 platform in July 2011. 6 months passed, there are only A75 and A55 chipsets support FM1 platform. However, FM1 CPU is getting more and more. Mainly it s for mid to low market. The C/P is quite well. http://www.twcarpc.com/photo/wwm/2012/A63500/A6350001.jpg FM1 has X4/6 series as 4 Cores or K series for OC market. The main strength for FM1 platform is 3D performance of APU structure. How to pick higher built-in 3D graphic and CPU performance is key
Recipe 1. 1 ul each outer oligo (10 uM) 2. 1 ul purified pca product 3. .5 ul phusion 4. 10 ul 5x phusion buffer 5. 5 ul 2mM dNTPs 6. 32.5 ul H2O Program 1. 2 min initial denature at 94oC 2. 30 sec denature at 94oC 3. 30 sec anneal at 60oC [This should be high, as your outer oligos now have a huge overlap with the correct product] 4. 30 sec extension at 68oC 5. repeat 2-4 30 times total ...
Looking for online definition of Coronavirus infections in the Medical Dictionary? Coronavirus infections explanation free. What is Coronavirus infections? Meaning of Coronavirus infections medical term. What does Coronavirus infections mean?
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection ...
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract ...
Human Coronavirus-NL63 Infection is not Associated with Acute Kawasaki Disease | Springer for Research & Development
Shimizu, C., Shike, H., Baker, S. C., Garcia, F., van der Hoek, L., Kuijpers, T. W., Reed, S. L., Rowley, A. H., Shulman, S. T., Talbot, H. K. B., Williams, J. V., and Burns, J. C., 2005, Human coronavirus NL63 is not detected in the respiratory tract of children with acute Kawasaki disease, J. Infect. Dis. 192: 1767-1771CrossRefPubMedGoogle Scholar ...
Immune responses by glia during neurotropic coronavirus induced encephalomyelitis :: University of Southern California...
The data presented in this thesis is incorporated into the model of early events of coronavirus infection and focuses on the innate responses by glia and their potential interactions with the mounting adaptive immune response. By utilizing transgenic mice to purify distinct populations of glia at different times during coronavirus infection of the central nervous system, the unique cell-specific responses can be evaluated in vivo to provide a fuller picture of the events leading to persistent viral infection. These new findings emphasize the protective role of microglia in providing early IFNalphabeta expression and the indirect modulation of this response by T cell activity. Microglia express a broad repertoire of pathogen associated pattern receptors (i.e. TLRs and RIG-I family helicases) and thereby trigger IFNalphabeta expression in direct response to viral infection. IFNalphabeta expression declines in correlation with effective clearance of virus from microglia by T cell activity. ...
I previously posted our Human hN2 Neurons being used for studying the mechanisms of Nerve Agent VX: hN2 Human Neurons for Toxicity Screening. The versatility of these neurons enabled the researchers to perform a microarray study in which cultured human neural cells were exposed to 0.1 or 10 μM of VX for 1 h. Global gene expression changes were analyzed 6, 24, and 72 h post exposure. Solid primary cell based assay results start with healthy and well behaving cells ...
Hungary Preparing for Mass Coronavirus Infections with Temporary Hospitals, Pre-screening Tents | NewsPortal.HU
Due to the spread of the coronavirus in Hungary and that the epidemic is at the stage of transmissions in communities and will soon progress to the stage of mass ...
Canadas National Microbiology Laboratory is developing diagnostic tests for the new coronavirus infection that has sickened at least 40 people worldwide and caused at least 20 deaths.
... The coronavirus (Covid-19) is spreading around the world and killing people. Governments know that It is reaching epidemic proportions that will cause all of us concern, but for some individuals, it will be worse than a concern; it will be Post-traumatic Stress Disorder. PTSD is a serious
There are new tests and updates everyday and we hope to update everyone as soon as we can with the most recent news on Coronavirus Covid-19 infection.. Vaccines? Work is progressing but we should not expect a vaccine for quite some time.. Testing? Yes, lots of updates this week. There are essentially 3 types of tests available. Lets analyse them together.. PCR Swab Testing. This is the test that is carried out by the government that involves a swab into the back of the throat/nose to get a sample of the viral shedding. This test takes 2-3 days to get a result. It tells you if you are ACTIVELY having a Coronavirus infection. It doesnt tell you if you have HAD IT IN THE PAST. For the test to work, it is very important to carry out the swab test correctly. Therefore, it is possible to get false negatives, meaning that you actively do have the virus but you werent able to get a good swab of the viral shredding, hence tested negative. At the clinic, we do not send the swabs out for this reason, ...
U.S. Food and Drug Administration Commissioner Stephen Hahn addressed the ongoing work of the agency in terms of its work on potential treatments and vaccines for the COVID-19 coronavirus currently spreading globally. Despite a claim early in Thursdays White House briefing on the pandemic by President
The U.S. Centers for Disease Control and Prevention has confirmed the first case in the U.S. of the deadly coronavirus. Health officials said a man in Washington state has the same virus that sickened about 300 people in China. Mark Strassmann reports.
Canadas first case of a new strain of coronavirus has been officially confirmed, Ontario health officials said Monday, as they announced the patients wife has also contracted the illness.
Children who visited an affected region in Italy on a family trip have presented no symptoms of the coronavirus, the council has said.
A newly identified coronavirus SARS-CoV-2 is spreading across the globe. Heres what you need to know about the virus and the disease it causes, COVID-19.
Can insects be coronavirus carriers that transmit the pathogen to humans? The jury is still out so people are advised to keep their homes clean and free of pests.
Nigeria on Monday reported its first death from coronavirus as confirmed cases of infections in Africas most populous nation climbed further.
Italy Coronavirus update with statistics and graphs: total and new cases, deaths per day, mortality and recovery rates, current active cases, recoveries, trends and timeline.
Chinese health officials said this new coronavirus is capable of being passed even before symptoms, like a fever, start presenting themselves.
The entire country of Italy is shut down as it attempts to slow the coronavirus outbreak and stem a rising death toll. Heres what it looks like.
Here is the collection of information you may need for your coronavirus essay. All the basic information is at one place for you to comfortably use.
Preliminary research conducted by Chinese scientists suggests that the new coronavirus, presumably, can not be transmitted from an infected mother to her unborn baby, a study published in The Lancet journal said
President Trump says Congress should swiftly approve a $2 trillion coronavirus stimulus bill, brushing off last-minute GOP concerns about a boost in unemployment insurance.
New Jersey man charged with terroristic threats after fake coughing on a Wegmans grocery store worker, saying he had coronavirus.
President Emmanuel Macron on Thursday said a coronavirus epidemic was inevitable in France as his government and others worldwide bolstered measures to fight the spread of infection.
ARTICLE:. J Dyall et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrobial Agents and Chemotherapy DOI: 10.1128/AAC.03036-14 (2014).. WHO:. NIAID Director Anthony S. Fauci., M.D., is available to comment on this research. Co-author Lisa Hensley, Ph.D., associate director for science, NIAID Integrated Research Facility, is also available to discuss the findings.. CONTACT:. To schedule interviews, please contact Anne A. Oplinger, (301) 402-1663, [email protected] For additional information about research on MERS and other coronaviruses by NIAID scientists and grantees, see: http://www.niaid.nih.gov/topics/coronavirus/Pages/default.aspx.. The study was funded, in part, by NIAID grant AI095569.. NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating ...
Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection | Annals of...
Acknowledgment: The authors thank the members of the Department of Clinical Nursing and the Infection Prevention and Control Program, King Abdulaziz Medical City, Riyadh, Saudi Arabia, for their assistance. They also thank the following persons: From the King Saud bin Abdulaziz University for Health Sciences, Riyadh: Sameera Johani, MD, Division of Microbiology, Pathology & Laboratory Medicine; Abdullah Ghamdi, MD, Department of Cardiac Sciences; Ghassan A. Al-Ghamdi, MD, Intensive Care Department and Assistant Professor, College of Medicine; Saqib I. Dara, MD, Intensive Care Department; Raed A. Hijazi, MD, Emergency Medicine; Olivia A. Trinidad, RRT, Edgardo Tabhan, RRT, and Charina Olay, RRT, all Respiratory Therapist I, Respiratory Services. From the King Abdulaziz Hospital, Al-Ahsa: Yusri Taha, MD, and Mohammed Ayman El Gammal, MD, Infectious Diseases, Department of Medicine and Abdulsalam Al-Aithan, MD, Pulmonary & Intensive Care Medicine. From the Imam Abdulrahman Bin Faisal Hospital, ...
Human coronavirus OC43 - Wikipedia
Human coronavirus OC43 is an enveloped, positive-stranded RNA virus in the species Betacoronavirus-1 (genus Betacoronavirus, ... "Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a ... Van Der Hoek, L (2007). "Human coronaviruses: What do they cause?". Antiviral Therapyapy. 12 (4 Pt B): 651-8. PMID 17944272. ... ISBN 978-1-55581-371-0. Pyrc, K.; Berkhout, B.; Van Der Hoek, L. (2007). "Antiviral Strategies Against Human Coronaviruses". ...https://en.wikipedia.org/wiki/Human_coronavirus_OC43
HE - Hemagglutinin-esterase precursor - Human coronavirus OC43 (HCoV-OC43) - HE gene & protein
Human coronavirus OC43 (HCoV-OC43). Bovine coronavirus. Camel coronavirus HKU23. Waterbuck coronavirus US/OH-WD358-GnC/1994. ... Human coronavirus OC43 (HCoV-OC43). Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV). Bovine coronavirus. Giraffe ... Human coronavirus OC43 (HCoV-OC43). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section"> ... sp,P30215,HEMA_CVHOC Hemagglutinin-esterase OS=Human coronavirus OC43 OX=31631 GN=HE PE=3 SV=1 ...http://www.uniprot.org/uniprot/P30215
Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus...
Two group 2 coronaviruses, human coronavirus OC43 (HCoV-OC43) and bovine coronavirus (BCoV), show remarkable antigenic and ... Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus ... This is the first animal-human zoonotic pair of coronaviruses that can be analyzed in order to gain insights into the processes ... Coronaviruses are enveloped, positive-stranded RNA viruses with a genome of approximately 30 kb. Based on genetic similarities ...https://www.uniprot.org/citations/15650185
Development of One-Step, Real-Time, Quantitative Reverse Transcriptase PCR Assays for Absolute Quantitation of Human...
Human coronaviruses are only seldom detected in clinical laboratories. Although human coronavirus OC43 and 229E infections are ... Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction. J. Virol. Methods 97:59-66. ... Viral propagation.Human coronaviruses OC43 and 229E were obtained from the American Type Culture Collection (VR-759 and VR-740 ... Evaluation of nested polymerase chain methods for the detection of human coronaviruses 229E and OC43. Mol. Cell. Probes 8:357- ...https://jcm.asm.org/content/43/11/5452
Complete Genome Sequence of Human Coronavirus OC43 Isolated from Mexico | Microbiology Resource Announcements
Human coronaviruses have the largest RNA genomes. Human coronavirus (HCoV) OC43 belongs to the Betacoronavirus genus of the ... Complete Genome Sequence of Human Coronavirus OC43 Isolated from Mexico. B. T. Taboada, P. Isa, M. A. Espinoza, F. E. Aponte, M ... Complete Genome Sequence of Human Coronavirus OC43 Isolated from Mexico. B. T. Taboada, P. Isa, M. A. Espinoza, F. E. Aponte, M ... Complete Genome Sequence of Human Coronavirus OC43 Isolated from Mexico. B. T. Taboada, P. Isa, M. A. Espinoza, F. E. Aponte, M ...https://mra.asm.org/content/4/6/e01256-16
Get PDF - Polypeptides and functions of antigens from human coronaviruses 229E and OC43
Polypeptides and functions of antigens from human coronaviruses 229E and OC43 ... Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43. Journal of Virology 71(1): 800-806, ... Survival of human coronaviruses 229E and OC43 in suspension and after drying onsurfaces: a possible source ofhospital-acquired ... Detection of antibodies to human coronaviruses 229E and OC43 in the sera of multiple sclerosis patients and normal subjects. ...https://eurekamag.com/research/043/975/043975223.php
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and...
Human coronavirusOC433CLpro Homology modellingMolecular dynamics. Background. Human coronaviruses have a worldwide distribution ... Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and ... This study will detail the generation of a homology model of the 3CLpro of the human coronavirus OC43 and determine the ... The high degree of identity can be partly expected as both OC43 and HKU1 are human coronaviruses from the Betacoronavirus genus ...https://bmcstructbiol.biomedcentral.com/articles/10.1186/s12900-015-0035-3
Recombinant Human HCoV OC43 N Protein rep-1054H - Creative BioMart
Recombinant Human HCoV OC43 N Protein can be used for research. ... Purified Recombinant Human HCoV OC43 N Protein from Creative ... Human. Form:. Human coronavirus OC43 (hCoV-OC43) is an enveloped, positive-stranded RNA virus. HCoV-OC43 causes a significant ... Recombinant Human HCoV OC43 N Protein. Download Datasheet See All rep Products. Bring this labeled protein directly to your ...https://www.creativebiomart.net/recombinant-human-hcov-oc43-n-protein-502888.htm
Coronavirus - Conservapedia
Human Coronavirus 229E (HCoV-229E). *Human Coronavirus OC43 (HCoV-OC43). *Human Coronavirus NL63 (HCoV-NL63) ... Coronavirus • COVID-19 • Contagious coronavirus • Coronavirus civil rights • coronavirus incubation period • coronavirus ... Coronavirus Real-Time Statistics. *A SARS-Like Cluster Of Circulating Bat Coronaviruses Shows Potential For Human Emergence, ... Middle Eastern Coronavirus Respiratory Syndrome (MERS-CoV), also known as Novel Coronavirus 2012 (2012-nCoV) and Human ...https://www.conservapedia.com/China_virus
IUCr) Acta Crystallographica Section F Volume 66, Part 7, July 2010
Crystals of the N-terminal domain of nucleocapsid protein from human coronavirus OC43 were obtained that diffracted X-rays to a ... Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid ... Cover illustration: The role of a topologically conserved isoleucine in the structure of human GSTA1-1 (Achilonu et al., p. 776 ... 2.2 and 2.7 Å resolution data sets were collected from crystals of the human apurinic/apyrimidinic endonuclease 1 (APE1) ...http://journals.iucr.org/f/issues/2010/07/00/
Coronavirus - Wikipedia
Human coronavirus 229E Human coronavirus OC43 SARS-CoV Human Coronavirus NL63 (HCoV-NL63, New Haven coronavirus) Human ... Bovine coronavirus and human coronavirus OC43 diverged in 1899. Bovine coronavirus diverged from the equine coronavirus species ... Another estimate suggests that human coronavirus OC43 diverged from bovine coronavirus in 1890. The MRCA of human coronavirus ... These viruses were subsequently named human coronavirus 229E and human coronavirus OC43. Coronaviruses primarily infect the ...https://en.wikipedia.org/wiki/Coronavirus
Coronaviruses | SpringerLink
... have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and human diseases ... Regulation of Persistent Infections with Human Coronavirus OC43 Arlene R. Collins. Pages 273-274 ... RNA Recombination of Coronavirus James G. Keck, Shinji Makino, Lisa H. Soe, John O. Fleming, Stephen A. Stohlman, Michael M. C ... Coronaviruses have emerged during the past ten years from being a group of viruses causing a variety of minor veterinary and ...https://link.springer.com/book/10.1007%2F978-1-4684-1280-2
Hou, M.H., Hsu, Y.L., Huang, C.Y. and Chiang, W.L. (2007). Characterization of human coronavirus OC43 nucleocapsid protein. ... Hou,M.H., Hsu, Y.L., Huang, C.Y. and Chiang, W.L. Characterization of human coronavirus OC43 nucleocapsid protein. Experimental ... Hou, M.H. and Huang, C.Y. (2007). The Studies of Biochemcal Properties and Stability of Recombinant Human Coronavirus OC43 ... Hou,M.H. and Huang, C.Y., The Studies of Biochemcal Properties and Stability of Recombinant Human Coronavirus OC43 Nucleocapsid ...https://www.nchu.edu.tw/~bif/html_zh/faculty-show.php?t=mhhou
PDB-6nzk: Structural basis for human coronavirus attachment to sialic acid ... - Yorodumi
Human coronavirus OC43. Method. ELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 2.8 Å Details. ... VIRAL PROTEIN / Coronavirus spike glycoprotein / sialic acid / HCoV-OC43 / fusion protein. Function / homology. Function and ... Structural basis for human coronavirus attachment to sialic acid receptors. Components. Spike surface glycoprotein Details. ... Title: Structural basis for human coronavirus attachment to sialic acid receptors.. Authors: M Alejandra Tortorici / Alexandra ...https://pdbj.org/emnavi/quick.php?id=pdb-6nzk
Coronaviruses: emerging and re-emerging pathogens in humans and animals
Despite the worldwide circulation of human coronavirus OC43 (HCoV-OC43) and HKU1 (HCoV-HKU1), data on their molecular ... Coronaviruses and the human airway: a universal system for virus-host interaction studies Human coronaviruses (HCoVs) are large ... Molecular characterization of human coronaviruses and their circulation dynamics in Kenya, 2009-2012 Human Coronaviruses (HCoV ... Molecular epidemiology and evolutionary histories of human coronavirus OC43 and HKU1 among patients with upper respiratory ...https://www.biomedcentral.com/collections/CoV
Publications - Dept. of Human Behavior, Ecology and Culture
The evolution of fancy social learning in humans accounts for both the nature of human adaptation and the extraordinary scale ... Ecology and Culture investigates the role of culture in human evolution and adaptation. ... and variety of human societies. The integration of ethnographic fieldwork with mathematical models and advanced quantitative ... Human coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016. Emerging Microbes & Infections,7: 118. Open Access ...https://www.eva.mpg.de/ecology/staff/wittig/publications.html?Fsize=%2F%27A%3D00%2C
Dept. of Primatology | Chimpanzees | Publications
Human coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016. Emerging Microbes & Infections,7(1): 118. Open Access ... Kalan, A. K. (2019). Humans impact on the behavior and cultural diversity of chimpanzees. The Science Breaker,5(4). Open ... Boesch, C. (2003). Is culture a golden barrier between human and chimpanzee? Evolutionary Anthropology,12(2), 82-91. DOI BibTeX ... Boesch, C., & Tomasello, M. (1998). Chimpanzee and human cultures. Current Anthropology,39(5), 591-614. DOI BibTeX Endnote ...https://www.eva.mpg.de/primat/research-groups/chimpanzees/publications.html?Fsize=0%25252525252C%252525252B%2525252540%252525252F%2525252527
Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia | Journal...
... with human coronavirus 229E (HCoV-229E) being a group 1 coronavirus and human coronavirus OC43 (HCoV-OC43) being a group 2 ... canine enteric coronavirus; HCoV-NL63, human coronavirus NL63; HCoV-OC43, human coronavirus OC43; MHV, murine hepatitis virus; ... coronavirus (SARS-CoV) (25), and human coronavirus NL63 (HCoV-NL63) (6, 37), two were coronaviruses. Coronaviruses possess the ... and human coronavirus NL63, were discovered. Here we report the discovery of another novel coronavirus, coronavirus HKU1 (CoV- ...https://jvi.asm.org/content/79/2/884?ijkey=08cec02dd04eed5cd2edd724b838441da9b86c52&keytype2=tf_ipsecsha
General Medical Care and the Education of Internists in University HospitalsAn Evaluation of the Teaching Hospital General...
Molecular epidemiological study of human coronavirus OC43 in Shanghai from 2009-2016]. ...http://annals.org/aim/article-abstract/699443/general-medical-care-education-internists-university-hospitals-evaluation-teaching-hospital
Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome | Science
... porcine respiratory coronavirus (PRCoV), z24675. Group 2: human coronavirus OC43 (HCoV-OC43), m76373, l14643, m93390; porcine ... bovine coronavirus, human coronavirus OC43, porcine hemagglutinating encephalomyelitis virus, mouse hepatitis virus, and rat ... Human coronaviruses (HCoVs) are found in both group 1 (HCoV-229E) and group 2 (HCoV-OC43) and are responsible for ∼30% of mild ... and Hong Kong isolated a novel coronavirus (SARS-CoV) from SARS patients. Unlike other human coronaviruses, it was possible to ...https://science.sciencemag.org/content/300/5624/1394?ijkey=8b4b7ca3b42eee634ac164f724c2b9c2127f942d&keytype2=tf_ipsecsha
Characterization of a Coronavirus Isolated from a Diarrheic Foal | Journal of Clinical Microbiology
... and human coronavirus (strain OC43); only limited identity (,25%) was observed with group 1 and group 3 coronaviruses. Based on ... 1989) Sequence analysis of nucleocapsid gene and leader RNA of human coronavirus OC43. Virus Res. 12:1-9. ... Human coronavirus (HCV) strain 229E, porcine transmissible gastroenteritis virus (TGEV), canine coronavirus, and feline ... Coronavirus sequences were obtained from the GenBank database. These included BCV Mebus and F15, MHV A59, HCV OC43 and 229E, ...https://jcm.asm.org/content/38/12/4523
Kincaid J[au] - PubMed - NCBI
Complete Genome Sequences of Four Novel Human Coronavirus OC43 Isolates Associated with Severe Acute Respiratory Infection. ... Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.. Gregory M, Mak PJ, Sligar SG, ... Erratum for Kennedy et al., "Genome Sequences of Three Novel Isolates of Human Parainfluenza Virus 2 Associated with Acute ... Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kincaid+J%5Bau%5D&dispmax=50
Science Clips - Monday, August 08, 2011
... of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43 ... Deaths associated with human adenovirus-14p1 infections, Europe, 2009-2010External. Carr MJ, Kajon AE, Lu X, Dunford L, ... Novel arenavirus infection in humans, United StatesExternal. Milazzo ML, Campbell GL, Fulhorst CF.. Emerg Infect Dis. 2011 Aug; ... The connection between human papillomavirus and oropharyngeal squamous cell carcinomas in the United States: implications for ...https://www.cdc.gov/library/sciclips/issues/v3issue32.html
HKU1NL63Complete genome sequenceCoronaviridaeNucleocapsidProteinHCoVInfect humansSingle-strandedPneumoniaGenusReceptor-bindinFelineNucleotide sequenceReplicationDescribed in the 1960sGenomesAntigenicEntericHemagglutininAnalysesHomologyCanineBronchitis virusReceptorsEncodesStructuralColdsIsolationCausative
- Betacoronavirus RNA virus Human coronavirus HKU1 Positive/negative-sense http://www.cdc.gov/coronavirus/about/ http://virology-online.com/viruses/CORZA4.htm Coronaviruses Viralzone: Betacoronavirus Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae Lau, Susanna K. P. (wikipedia.org)
- Only recently, two novel human coronavirus types associated with lower respiratory tract infections have been characterized: HCoV NL63 and HCoV HKU1 ( 3 , 16 , 19 ). (asm.org)
- Despite the worldwide circulation of human coronavirus OC43 (HCoV-OC43) and HKU1 (HCoV-HKU1), data on their molecular epidemiology and evolutionary dynamics in the tropical Southeast Asia region is lacking. (biomedcentral.com)
- Here we report the discovery of another novel coronavirus, coronavirus HKU1 (CoV-HKU1), from a 71-year-old man with pneumonia who had just returned from Shenzhen, China. (asm.org)
- The complete genome sequence of CoV-HKU1 is a 29,926-nucleotide, polyadenylated RNA, with G+C content of 32%, the lowest among all known coronaviruses with available genome sequence. (asm.org)
- Phylogenetic analysis reveals that CoV-HKU1 is a new group 2 coronavirus. (asm.org)
- Based on the findings of this study, we propose that this new virus be designated coronavirus HKU1 (CoV-HKU1). (asm.org)
- The group II coronaviruses (OC43 and HKU1) were significantly associated with race ( P ≤ 0.009 and P ≤ 0.03, respectively). (asm.org)
- More recently isolated human coronaviruses described in 2004 and 2005 include NL63, which is a member of group I, and HKU1, which is a member of group II ( 20 , 21 ). (asm.org)
- In the past 3 years, several novel respiratory viruses, including human metapneumovirus, severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and human coronavirus NL63, were discovered. (asm.org)
- Of the three novel agents identified in recent 3 years, including human metapneumovirus ( 36 ), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) ( 25 ), and human coronavirus NL63 (HCoV-NL63) ( 6 , 37 ), two were coronaviruses. (asm.org)
- Recently, a novel group 1 human coronavirus associated with respiratory tract infections, HCoV-NL63, was discovered, and its genome was sequenced ( 37 ). (asm.org)
- Elevated OC43 IgG levels were further significantly associated with smoking status ( P ≤ 0.03), as were high NL63 titers with socioeconomic status ( P ≤ 0.04). (asm.org)
- Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M) and nucleocapsid (N). In the specific case of the SARS coronavirus (see below), a defined receptor-binding domain on S mediates the attachment of the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). (wikipedia.org)
- Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: implications for the diagnosis of coronavirus infection. (nchu.edu.tw)
- Antigenic and genomic characterizations of the virus (isolate NC99) were based on serological comparison with other avian and mammalian coronaviruses and sequence analysis of the nucleocapsid (N) protein gene. (asm.org)
- As with mouse hepatitis coronaviruses (MHVs), the SDAV genome was able to code for a spike protein, a small membrane protein, a membrane-associated protein, and a nucleocapsid protein. (asm.org)
- We prepared recombinant nucleocapsid antigens following baculovirus cloning and expression in insect cell cultures and used these proteins to devise novel enzyme-linked immunosorbent assays (ELISAs) specific for the target coronavirus antigens. (asm.org)
- The translation involves the production of an RNA-dependent RNA-polymerase (L protein) which transcribes a single negative-stranded RNA from which it is then possible to obtain new positive-stranded RNAs of the coronavirus as well as the seven proteins that it encodes. (conservapedia.com)
- Some coronaviruses (specifically the members of Betacoronavirus subgroup A) also have a shorter spike-like protein called hemagglutinin esterase (HE). (wikipedia.org)
- A fragment of the spike classical coronaviruses as a tool to test human coronavirus- protein gene was sequenced to determine the variety of cir- es (except SARS-CoV). (cdc.gov)
- the complete N protein of NC99 (446 amino acids) was then compared with published N protein sequences of other avian and mammalian coronaviruses. (asm.org)
- Additionally, some coronaviruses also contain a fourth major structural protein, the hemagglutinin-esterase protein (120 to 140 kDa) ( 12 , 26 ). (asm.org)
- The sequence information on the SDAV S-protein gene was applied to a differential diagnostic PCR to detect and distinguish the rat coronavirus from mouse coronaviruses. (asm.org)
- To these ends, we have performed cDNA cloning of the entire structural-protein region of the sialodacryoadenitis rat coronavirus genome, and in this communication we report the complete sequence of the 3′ terminal 9.8 kb of the SDAV genomic RNA. (asm.org)
- Mouse hepatitis coronavirus (MHV) uses the N-terminal domain (NTD) of its spike protein as its receptor-binding domain. (nih.gov)
- Four HCoV-OC43 genotypes (A to D), have been identified with genotype D most likely arising from recombination. (wikipedia.org)
- Nucleotide and amino acid similarity percentages were determined for the major HCoV-OC43 ORFs and for those of other group 2 coronaviruses. (uniprot.org)
- The highest degree of similarity is demonstrated between HCoV-OC43 and BCoV in all ORFs with the exception of the E gene. (uniprot.org)
- Molecular clock analysis of the spike gene sequences of BCoV and HCoV-OC43 suggests a relatively recent zoonotic transmission event and dates their most recent common ancestor to around 1890. (uniprot.org)
- The HCoV OC43 assay allows quantitation over a range from 20 to 2 × 10 8 RNA copies per reaction mixture (5 μl RNA extract). (asm.org)
- Human coronaviruses (HCoVs) cause respiratory tract illnesses, but enteric and potential neurological diseases are also frequent outcomes of HCoV infection ( 1 , 13 ). (asm.org)
- A total of 12,330,418 reads were generated and 1,657,101 (13.44%) were mapped to the consensus sequence of HCoV OC43. (asm.org)
- Human coronavirus OC43 (hCoV-OC43) is an enveloped, positive-stranded RNA virus. (creativebiomart.net)
- HCoV-OC43 causes a significant fraction of upper respiratory tract infections, especially common colds. (creativebiomart.net)
- Inside the cytoplasm of the cell, the coronavirus releases its positive single-stranded RNA which attaches itself to the ribosomes where it is translated. (conservapedia.com)
- The coronavirus genome consists of a positive-sense, single-stranded RNA molecule that is 20 to 30 kb in size ( 19 , 26 ). (asm.org)
- Coronavirus is an enveloped virus with a single-stranded positive-sense RNA genome of approximately 31 kb. (asm.org)
- Feline Coronavirus: two forms, Feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis (FIP), a disease associated with high mortality. (wikipedia.org)
- Four human and one feline coronavirus antigen were cloned into baculoviruses expressed in insect cells and recovered proteins bound in the solid phase of an enzyme-linked immunosorbent assay-based system. (asm.org)
- No evidence of a significant serological response to the feline coronavirus was observed. (asm.org)
- The genome is closely related to the other OC43 genome sequences available, ranging from 99.8% to 98.2% nucleotide sequence identity. (asm.org)
- Coronaviruses have been subdivided into three major antigenic groups based on antigenic differences identified by serological analyses, and these findings have been substantiated by nucleotide sequence analyses ( 21 , 22 , 29 ). (asm.org)
- During coronavirus replication the large open reading frame (ORF) 1a/1ab genes, located at the 5' end of the genome, are responsible for expressing two large replicase polyproteins (pp). (biomedcentral.com)
- Replication of Coronavirus begins with entry to the cell which takes place in the cytoplasm in a membrane-protected microenvironment. (wikipedia.org)
- Similarly, there are two types of coronavirus that infect ferrets: Ferret enteric coronavirus causes a gastrointestinal syndrome known as epizootic catarrhal enteritis (ECE), and a more lethal systemic version of the virus (like FIP in cats) known in ferrets as ferret systemic coronavirus (FSC). (wikipedia.org)
- The receptor-interacting site is conserved in all coronavirus S glycoproteins that engage 9-O-acetyl-sialogycans, with an architecture similar to those of the ligand-binding pockets of coronavirus hemagglutinin esterases and influenza virus C/D hemagglutinin-esterase fusion glycoproteins. (pdbj.org)
- This study will detail the generation of a homology model of the 3CL pro of the human coronavirus OC43 and determine the potential of 16R to form a broad-spectrum lead compound. (biomedcentral.com)
- A high quality homology model of the OC43 3CL pro was successfully generated in an active conformation. (biomedcentral.com)
- Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. (nih.gov)
- Unexpectedly, MHV NTD contains a core structure that has the same β-sandwich fold as human galectins (S-lectins) and additional structural motifs that bind to the N-terminal Ig-like domain of mCEACAM1a. (nih.gov)
- Structural analysis and mutagenesis localize the sugar-binding site in coronavirus NTDs to be above the β-sandwich core. (nih.gov)
- We propose that coronavirus NTDs originated from a host galectin and retained sugar-binding functions in some contemporary coronaviruses, but evolved new structural features in MHV for mCEACAM1a binding. (nih.gov)
- In OC43 by virus isolation and RT-PCR. (cdc.gov)
- A coronavirus antigenically related to BCV was identified in feces and intestinal tissues of a diarrheic foal, based on immunohistochemistry and an antigen-capture enzyme-linked immunosorbent assay, but virus isolation attempts were unsuccessful ( 7 ). (asm.org)