Coronavirus NL63, Human

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Coronavirus 229E, Human

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Spike Glycoprotein, Coronavirus

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Human coronavirus NL63 - Wikipedia

A Study of Human Coronavirus NL63: Characterization of Virus Replicati by Bridget Banach

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Human coronavirus NL63

Coronavirus diseases

Human coronavirus 229E

History of coronavirus

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Coronavirus spike protein

Coronavirus

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List of virus species

229E27

• It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. (nih.gov)
• The majority of healthy children seroconverted for HCoV-OC43 (n=19) and HCoV-NL63 (n=17), less for HCoV-HKU1 (n=9) and HCoV-229E (n=5). (nih.gov)
• Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). (nih.gov)
• Again we observed most infection by HCoV-OC43 (n=85) and HCoV-NL63 (n=60), followed by HCoV-HKU1 (n=47) and HCoV-229E (n=15). (nih.gov)
• HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. (nih.gov)
• HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. (nih.gov)
• Phylogenetic analysis showed that HCoV-NL63 is a new group 1 coronavirus, most closely related to HCoV-229E. (cdc.gov)
• Samples were also tested for human metapneumovirus (HMPV), rhinovirus, enterovirus, and HCoV 229E and OC43 by virus isolation and RT-PCR. (cdc.gov)
• Four human coronaviruses (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) are associated with a range of respiratory outcomes, including bronchiolitis and pneumonia. (ed.ac.uk)
• People around the world commonly get infected with human coronaviruses 229E, NL63, OC43, and HKU1. (cdc.gov)
• First, the SARS-CoV-2 spike (SARS-2-S) reached higher levels in pseudoparticles when produced at 33°C instead of 37°C. Even stronger preference for the upper airway temperature of 33°C was evident for the S protein of HCoV-229E, a common cold coronavirus. (biorxiv.org)
• TMPRSS13 was found to be an effective spike activator for the virulent coronaviruses but not the common cold HCoV-229E virus. (biorxiv.org)
• Four of those types (229E, NL63, OC43 and HKU1) cause only mild or moderate upper-respiratory illness, such as the common cold. (mdanderson.org)
• In the peer-review paper, which was co-authored by Dr. DeGrado and is accessible at the link below, University of Arizona and University of California-San Francisco scientists characterized the antiviral activity of Brilacidin against multiple endemic human coronaviruses (HCoVs), including HCoV-OC43, HCoV-229E, HCoV-NL63, and SARS-CoV-2, in human cell lines. (biospace.com)
• S-20-1 could effectively inhibit infection by pseudotyped and authentic SARS-CoV-2 and pseudotyped variants of concern (VOCs), including B.1.617.2 (Delta) and B.1.1.529 (Omicron), as well as MERS-CoV, SARS-CoV, HCoV-OC43, HCoV-229E, and HCoV-NL63. (nature.com)
• A diagnosis with coronavirus 229E, NL63, OC43, or HKU1 is not the same as a COVID-19 diagnosis. (mmchs.org)
• Similar patterns for 2 other endemic coronaviruses, HCoV-229E and HCoV-OC43, were observed. (lshtm.ac.uk)
• In the current work, the researchers used a multigene and whole-genome analysis technique to evaluate the evolutionary background of sHCoVs (NL63, 229E, HKU1, and OC43). (news-medical.net)
• Influenza and the four human coronaviruses that cause common colds (OC43, 229E, NL63 and HKU1) are, of course, also endemic, but a combination of annual flu vaccines and acquired immunity means that sane societies tolerate the unavoidable seasonal deaths and illnesses they bring without requiring lockdowns, masks, social distancing, indefinite return-to-work delays, etc. (macdailynews.com)
• This was in spite of the presence of different coronaviruses that could infect humans (OC43, HKU1, NL63 and 229E). (thewire.in)
• Description: Human coronavirus 229E is a single-stranded, positive-sense, RNA virus species in the Alphacoronavirus genus of the subfamily Coronavirinae, in the family Coronaviridae, of the order Nidovirales. (diastrip.com)
• There are four globally distributed known human coronaviruses - HCoV-229E, HCoV-HKU1, HC0V-NL63 and HCoV-OC43, which are found in different locations around the world at different times of the year. (diastrip.com)
• Coronavirus 229E and Human coronavirus OC43 are known to be the cause for the common cold. (diastrip.com)
• Additionally, between the Coronaviruses, HCoV-229E is the most frequently co-detected with other respiratory viruses, mainly with HRSV (Human respiratory syncytial virus). (diastrip.com)
• The viruses of 229E, OC43, NL63 and HKU1 only cause common cold symptoms, which are mild. (ijbs.com)
• Risk factors for healthcare personnel infection with endemic coronaviruses (HKU1, OC43, NL63, 229E): results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT). (cdc.gov)
• Most people are infected with common coronaviruses throughout their lives, but only four of them cause common cold symptoms: alpha coronavirus 229E and NL63 and beta coronavirus OC43, HKU1 (V) 1 . (bvsalud.org)

OC431

• The current observations widen the list of putative OC43 origin or intermediate hosts to incorporate other rabbits, ungulates, and canines, either wild or domesticated yet always close to humans. (news-medical.net)

HKU14

• In 2004, the increase in research on theses viruses soon led to the discovery of 2 other human coronaviruses, HCoV-NL63 in the Netherlands and, more recently, CoV-HKU1 in China ( 1 - 3 ). (cdc.gov)
• Other strands such as HKU1 and NL63 are present in many upper and lower respiratory infections. (as.com)
• The scientists hypothesized that two autonomous non-human to human transmission incidents could occur in HKU1. (news-medical.net)
• The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. (zombiemall.com)

Viruses25

• Generally, coronaviruses displayed marked winter seasonality between the months of December and April and were not detected in summer months, which is comparable to the pattern seen with influenza viruses. (ed.ac.uk)
• A total of 11 to 41% of coronaviruses detected were in samples testing positive for other respiratory viruses, although clinical presentations of coronavirus monoinfections were comparable to those of viruses which have an established role in respiratory disease, such as respiratory syncytial virus, influenza virus, and parainfluenza viruses. (ed.ac.uk)
• This is of particular importance to coronaviruses, as these viruses are considered to bind to the host cell by attaching first to HSPGs using them as preliminary docking sites on the host cell surface. (frontiersin.org)
• Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans," notes the study abstract . (theepochtimes.com)
• Human coronaviruses are a family of viruses that are found throughout the world. (mdanderson.org)
• Coronavirus is a family of viruses that typically causes the common cold and upper respiratory symptoms. (epmonthly.com)
• Dr Tyrrell's team realised a few other viruses had the same pattern on their surfaces, and decided to call them coronaviruses. (thewire.in)
• Coronaviruses are a group of viruses that use RNA as their genetic material, instead of DNA, the genetic material of nearly all organisms on Earth. (thewire.in)
• And of all RNA viruses, coronaviruses have some of the largest genomes . (thewire.in)
• Different coronaviruses use different receptors, but the SARS-CoV and SARS-CoV-2 viruses both use the same protein, called angiotensin converting enzyme 2 (ACE2). (thewire.in)
• Any cell that makes the ACE2 protein - including all cells of the human respiratory tract - can be infected by both the viruses. (thewire.in)
• Coronaviruses are positive-sense single-stranded ribonucleic acid (RNA) viruses causing a broad spectrum of diseases in domestic and wild animals including poultry and rodents. (scialert.net)
• Coronaviruses are ribonucleic acid (RNA) viruses causing a wide spectrum of diseases in humans, domestic and wild animals, poultry and rodents. (scialert.net)
• Some of the animal viruses like Porcine transmissible gastroenteritis virus (TGEV), Bovine coronavirus (BCV), Avian infectious bronchitis viruses (IBV) are of high veterinary significance. (scialert.net)
• Coronaviruses, positive-sense single-stranded ribonucleic acid (RNA) viruses with helical nucleocapsids, are the members of the Coronavirus genus of the Coronaviridae family, order Nidovirales. (scialert.net)
• Typically, respiratory pathogens such as respiratory syncytial virus (RSV), common cold coronaviruses, parainfluenza viruses, and respiratory adenoviruses increase in the fall and remain high throughout winter, following the same basic patterns as influenza . (the-hospitalist.org)
• These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. (zombiemall.com)
• Later that decade, researchers found a group of similar human and animal viruses and named them after their crown-like appearance. (scienceoxygen.com)
• Coronavirus is a family of viruses that can cause respiratory illnesses such as the common cold, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). (scienceoxygen.com)
• Coronaviruses are a large family of viruses. (scienceoxygen.com)
• Coronaviruses (CoVs) are members of the family Coronaviridae, the enveloped viruses that possess extraordinarily large single-stranded RNA genomes ranging from 26 to 32 kilobases in length [ 2 ]. (ijbs.com)
• AQUICHAN - ISSN 1657-5997 - eISSN 2027-5374 chronic non-communicable diseases with respiratory infection by viruses of the coronavirus family, from 2010 to 2020. (bvsalud.org)
• The SARS-related coronavirus was one of several viruses identified by the World Health Organization (WHO) in 2016 as a likely cause of a future epidemic in a new plan developed after the Ebola epidemic for urgent research and development before and during an epidemic towards diagnostic tests , vaccines and medicines . (wikizero.com)
• Coronaviruses (CoV) make up a large family of viruses, known since the mid-1960s, which received this name due to the spikes on its surface, which resemble a crown (from the Latin corona). (bvsalud.org)
• Coronavirus is a family of viruses that cause respiratory infections, being SARS-CoV2 the seventh coronavirus in this family. (bvsalud.org)

SARS69

• In 2003, human coronaviruses received worldwide attention with the emergence of severe acute respiratory syndrome (SARS) caused by a novel coronavirus (SARS-CoV). (cdc.gov)
• We also evaluated a multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for classical coronaviruses as a tool to test human coronaviruses (except SARS-CoV). (cdc.gov)
• The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a newly emerged virus that first appeared in December 2019. (hindawi.com)
• Of importance are Heparan Sulfate Proteoglycans (HSPGs) and the host receptor angiotensin-converting enzyme 2 (ACE2), as based on other activities lactoferrin might prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from attaching to the host cells. (frontiersin.org)
• LF is known to interfere with some of the receptors used by coronaviruses, it may thus contribute usefully to the prevention and treatment of SARS CoV-2 infections. (frontiersin.org)
• The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other highly pathogenic coronaviruses SARS-CoV-1 and MERS-CoV. (biorxiv.org)
• SIGNIFICANCE STATEMENT The rapid spread of SARS-CoV-2, the cause of COVID-19, is related to abundant replication in the upper airways, which is not observed for other highly pathogenic human coronaviruses. (biorxiv.org)
• We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. (theepochtimes.com)
• The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) in Wuhan, China, which rapidly grew into a global pandemic, marked the third introduction of a virulent coronavirus into the human society, affecting not only the healthcare system, but also the global economy. (mdpi.com)
• While this would make SARS-CoV-2 the least deadly of the 3 most pathogenic human coronaviruses, its relative virulence has shown an ability to overwhelm even relatively advanced health infrastructures, as noted by a current case fatality rate in Italy of 8.37% as of March 18, 2020. (ebmedicine.net)
• SARS-CoV is the most aggressive version of coronaviruses and in 2003, it killed 800 people. (as.com)
• SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly impacted global human health. (biomedcentral.com)
• We used direct RNA sequencing to determine the transcriptome of SARS-CoV-2 grown in Vero E6 cells which is widely used to propagate the novel coronavirus. (biomedcentral.com)
• Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a human pathogen at the end of 2019, the virus has spread globally, causing almost 11.1 million confirmed cases of COVID-19 and over half a million deaths as of the 7 July 2020 [ 1 ]. (biomedcentral.com)
• The genome sequence of SARS-CoV-2 was rapidly determined and revealed the virus is most closely related to bat coronavirus RaTG13 and clusters phylogenetically with SARS-CoV, which emerged in 2002, in the genus Betacoronavirus of the family Coronaviridae [ 3 , 4 ]. (biomedcentral.com)
• Similar, to other coronaviruses, the SARS-CoV-2 29.9 kB RNA genome contains two large ORFs, ORF1a and ORF1ab, predicted to be initially translated into the polyproteins, pp1a and pp1ab that arises by programmed (− 1) ribosomal frameshifting (Fig. 1 a). (biomedcentral.com)
• There are many variations of coronaviruses (listed below) so, not to confuse anyone on what it is we are talking about, we use COVID-19 or SARS-CoV-2, which is the pandemic we are dealing with globally. (tampafp.com)
• The receptor-binding domain (RBD) in S1 subunit and heptad repeat 1 (HR1) domain in S2 subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) and pan-coronavirus (CoV) fusion inhibitory peptides, respectively. (nature.com)
• It could also inhibit infection of a pseudotyped SARS-related coronavirus WIV1 (SARSr-CoV-WIV1) from bats. (nature.com)
• The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. (biomedcentral.com)
• During the fight against the novel coronavirus SARS-CoV-2 ultrasonicators are used for various applications in research, bio-science and pharma. (hielscher.com)
• The SARS-CoV-2 coronavirus, also known as 2019-nCoV or novel coronavirus 2019, is responsible for the COVID-19 pandemic, which started in December 2019 in Wuhan, China and spread from there across the world. (hielscher.com)
• The main route of human to human transmission of SARS-CoV-2 is by having close contact to infected persons: Respiratory droplets generated by sneezing and coughing of an infected person are inhaled by others, so that they get subsequently infected. (hielscher.com)
• Coronaviruses such as SARS-CoV-2 attach to the angiotensin-converting enzyme 2 (ACE2) receptor, which are mainly found in the lungs (and to a smaller degree in the heart, intestines, arteries, and kidney). (hielscher.com)
• In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. (avivasysbio.com)
• But all of this changed when the coronaviruses that caused severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) emerged in 2002 and 2012, respectively. (thewire.in)
• The coronavirus responsible for the SARS outbreak is called SARS-CoV. (thewire.in)
• This virus, previously called the 2019 novel coronavirus, has since been renamed SARS-CoV-2. (thewire.in)
• However, recent studies have shown that the SARS-CoV-2 spike protein binds more strongly to the human ACE2 protein than the SARS-CoV spike protein. (thewire.in)
• Highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) has developed strategies to inhibit host immune recognition. (cipsm.de)
• Similarly to SUD, the PL pro s from SARS-CoV, MERS-CoV, and HCoV-NL63 physically interact with and stabilize RCHY1, and thus trigger degradation of endogenous p53. (cipsm.de)
• We show that p53 inhibits replication of infectious SARS-CoV as well as of replicons and human coronavirus NL63. (cipsm.de)
• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Nucleocapsid Protein Antibody is a chimaeric. (proteomecommons.org)
• Description: For the qualitative determination of IgG class antibodies against SARS Coronavirus in Human serum or plasma. (diastrip.com)
• It is intended for diagnosing and monitoring of patients related to infection by SARS Coronavirus. (diastrip.com)
• The SARS epidemic put the animal coronaviruses in the spotlight. (zombiemall.com)
• Yep, the Bird Flu (SARS) from 2003 is a type of coronavirus, but why is the one from now, 2019 - 2020, a good case study for zombies? (zombiemall.com)
• The coronavirus that causes COVID-19 is similar to the one that caused the 2003 SARS outbreak. (scienceoxygen.com)
• Since the 2019 coronavirus is related to the original coronavirus that caused SARS and can also cause severe acute respiratory syndrome, there is "SARS" in its name: SARS-CoV-2. (scienceoxygen.com)
• These coronaviruses range from the common cold to more severe diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19. (scienceoxygen.com)
• The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has now been continuing for more than two years. (bvsalud.org)
• In addition, the vaccination induced neutralizing antibodies against the more distantly related SARS-CoV-1 but not against NL63. (bvsalud.org)
• The results indicate that although SARS-CoV-2 humoral immune responses induced by infection wane, vaccination induces a broad neutralizing activity against multiple SARS-CoVs, but not to the common cold alpha-coronavirus NL63. (bvsalud.org)
• The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), etiological agent of the novel coronavirus disease 2019 (COVID-19), has spread since December 2019, resulting in massive health and economic crisis worldwide. (preprints.org)
• In addition to humans, serological and molecular based studies have demonstrated SARS CoV-2 exposure in several wild, domestic and farmed animals. (preprints.org)
• In Kenya SARS-CoV-2 was first detected on March 12th 2020 from imported human cases of persons who had travelled from the United States. (preprints.org)
• An ongoing outbreak of pneumonia caused by a novel coronavirus, currently designated as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was reported recently. (ijbs.com)
• The novel virus, previously called the 2019-novel coronavirus (2019-nCoV), is currently designated as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). (ijbs.com)
• CoVs have been identified in both avian hosts and various mammals, including bat, camels, dogs and masked palm civets, and are previously regarded as pathogens that only cause mild diseases in the immunocompetent people until the emergence of the coronavirus causing severe acute respiratory syndrome (SARS-CoV) in late of 2002 [ 3 - 6 ]. (ijbs.com)
• The genome sequence of SARS-CoV-2 (WH-Human_1) was first released and shared by China on 10 Jan [ 12 ]. (ijbs.com)
• Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. (qedbio.com)
• Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. (qedbio.com)
• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease, which has caused a pandemic in humans. (cdc.gov)
• A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in China in 2019 and later ignited a global pandemic. (bvsalud.org)
• Background: To control the spread of coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), it is necessary to adequately identify and isolate infectious patients particularly at the work place. (bvsalud.org)
• Sarah Gregory] Since the emergence of SARS-CoV-2, coronaviruses obviously are getting a lot more attention these days. (cdc.gov)
• Melisa Shah] SARS-CoV-2, the virus that causes coronavirus disease 2019 or COVID-19, has placed a lot more attention on the common human coronaviruses. (cdc.gov)
• There are other types of human coronaviruses, including the Middle East respiratory syndrome (or MERS) and the severe acute respiratory syndrome (or SARS), and of course COVID-19. (cdc.gov)
• All four common human coronaviruses, like you say, generally cause less severe disease than the types of coronaviruses that cause MERS, SARS, and COVID-19. (cdc.gov)
• This has been driven by fears arising from the rapid emergence, spread and public health impact of several recent outbreaks, such as the international spread of severe acute respiratory syndrome coronavirus (SARS-CoV) (2003), the potential of avian influenza H5N1 to emerge as a highly lethal pandemic as increasing numbers of human cases are reported (2003 and continuing), and the very rapid global spread of pandemic H1N1 influenza in 2009-2010. (who.int)
• Severe acute respiratory syndrome-related coronavirus ( SARSr-CoV or SARS-CoV ) [note 1] is a species of virus consisting of many known strains phylogenetically related to severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) that have been shown to possess the capability to infect humans , bats , and certain other mammals . (wikizero.com)
• Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome coronavirus 1 (SARS-CoV or SARS-CoV-1), which caused the 2002-2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the ongoing pandemic of COVID-19 . (wikizero.com)
• SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [12] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses , have only one papain-like proteinase ( PLpro ) instead of two in the open reading frame ORF1ab . (wikizero.com)
• Bats serve as the main host reservoir species for the SARS-related coronaviruses like SARS-CoV-1 and SARS-CoV-2. (wikizero.com)
• [16] Only recently have strains of SARS-related coronavirus been observed to have evolved into having been able to make the cross-species jump from bats to humans, as in the case of the strains SARS-CoV-1 and SARS-CoV-2 . (wikizero.com)
• The SARS-related coronavirus is an enveloped, positive-sense, single-stranded RNA virus . (wikizero.com)
• Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. (nature.com)
• CoV infections can cause everything from a common cold to severe respiratory syndromes, such as severe acute respiratory syndrome (SARS-CoV) and Middle Eastern respiratory syndrome (MERS-CoV).COVID-19 (SARS-CoV2) is a new variant of the coronavirus, and its isolation occurred in China on January 7th, 2020. (bvsalud.org)
• Thus, we aim to describe key topics of COVID-19: The new Coronavirus(SARS-CoV2) and its advances in the world population. (bvsalud.org)

Pandemic8

• This pathogen has spread rapidly, exhibiting tremendous morbidity and mortality to such an extent that the World Health Organization (WHO) officially declared the coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. (hindawi.com)
• Lactoferrin (LF) or lactotransferrin has recently come under the spotlight, particularly with regards to the new coronavirus pandemic that started in 2019 (COVID-19). (frontiersin.org)
• That was a harbinger of what was to come regarding the potential of mutating coronavirus and the effect it could have on the world as we are currently seeing during the current pandemic. (as.com)
• The 2020 award ceremony was delayed one year due to the coronavirus pandemic. (biospace.com)
• In addition to the neurobiology of COVID-19 and typical deliriogenic factors omnipresent in the ICU, this pandemic has created circumstances of extreme isolation and distancing from human contact whenever possible, including loved ones, plus the inability to freely ambulate, which essentially create a "delirium factory" that must be explicitly addressed to maximize human dignity and respect during care. (biomedcentral.com)
• The coronavirus responsible for the current pandemic is thought to have originated in bats. (thewire.in)
• But in spite of all that we know today about coronaviruses, some questions are still hard to answer, such as what course the current pandemic will take and if there will be future outbreaks of the same virus. (thewire.in)
• In December 2019, a pneumonia-like illness was first reported in Wuhan-China caused by a new coronavirus - corona virus disease-2019 (COVID-19) - which has since caused a global pandemic [ 1. Hui DS, Azhar EI, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020; 91: 264-266. [ CrossRef ] ">1 ]. (lidsen.com)

Type of coronavirus3

• Rest assured, it is not the same type of coronavirus disease, COVID-19, that is spreading around the world. (mdanderson.org)
• Description: Human coronavirus NL63 also known as HCoV-NL63 is a type of coronavirus that was identified in 2004. (diastrip.com)
• a new type of coronavirus was isolated by Chinese authority [ 10 ]. (ijbs.com)

20207

• During 2020, there has been a renewed interest in this receptor, due to the interactions of novel coronaviruses and their interactions with ACE2 ( 3 - 5 ). (frontiersin.org)
• A study published in the Jan. 10, 2020, issue of the journal Vaccine found people were more likely to get some form of coronavirus infection if they had been vaccinated against influenza. (theepochtimes.com)
• On 23 Feb 2020, the lock-down of Wuhan, a central city in China, has alarmed people all over the world of an emerging novel coronavirus that is posing a major public health and governance challenges. (ijbs.com)
• In March 2020, mild signs and symptoms of coronavirus disease developed in a healthy 33-year-old man in Hong Kong. (cdc.gov)
• Timeline of primary infection and reinfection with severe acute respiratory syndrome coronavirus 2, Hong Kong, August, 2020. (cdc.gov)
• To provide insight into the possible reasons for the presumed immune sufficiency to coronavirus disease 2019 (COVID-19) in Africa, this review critically examines literature published from 2020 onwards on the dynamics of COVID-19 infection and immunity and how other prevalent infectious diseases in Africa might have influenced the outcome of COVID-19. (bvsalud.org)
• Literature, National Library of Medicine e Scopus, del 15 al 30 de marzo del 2020, en portugués, inglés y español, con enfoque cuantitativo y cualitativo en adultos con enfermedades crónicas no transmisibles con infección respiratoria por virus de la familia del coronavírus, del 2010 al 2020. (bvsalud.org)

Infection11

• We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. (cdc.gov)
• We tested for HCoV-NL63 in children with acute respiratory tract infection hospitalized in Caen from November 2002 to April 2003, described symptoms associated with this infection, and examined local strains for the genetic variability. (cdc.gov)
• Data for 18 patients with recorded HCoV-NL63 infection were available and were examined retrospectively for specific respiratory symptoms. (cdc.gov)
• The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. (thelancet.com)
• Additionally, paired samples from 25 individuals with evidence of repeat HCoV-NL63 infection were selected for whole-genome virus sequencing. (lshtm.ac.uk)
• We report a case of human metapneumovirus infection that spread from humans to chimpanzees and back to humans. (cdc.gov)
• We report an outbreak of human metapneumovirus (hMPV) infection in chimpanzees and a zookeeper at this zoo. (cdc.gov)
• Nope, the Coronavirus doesn't have anything to do with zombies, but it's a damn good case study to see how fast such an infection can spread. (zombiemall.com)
• This allows establishing Nursing actions for the care of adults with chronic conditions and pulmonary infection related to coronavirus. (bvsalud.org)
• Nursing care for people with chronic diseases and pulmonary infection by coronavirus: An integrative review. (bvsalud.org)
• The genomic sequences from nine patients who were among the first cases of this serious infection (COVID-19) are almost genetically identical, which suggests the very recent appearance of this Coronavirus in humans 3 . (bvsalud.org)

Infections9

• Background: Human coronavirus NL63 (HCoV-NL63) is a globally endemic pathogen causing mild and severe respiratory tract infections with reinfections occurring repeatedly throughout a lifetime. (lshtm.ac.uk)
• Repeat infections by HCoV-NL63 were not accompanied by detectable genotype switching. (lshtm.ac.uk)
• Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. (zombiemall.com)
• In humans there are several known coronaviruses that cause respiratory infections. (scienceoxygen.com)
• A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS . (bvsalud.org)
• Objective: To identify the implications, for Nursing, of pulmonary infections by coronavirus in people with chronic non-communicable diseases and to propose actions for care. (bvsalud.org)
• Melisa Shah] Generally, the common human coronaviruses can cause upper respiratory tract infections. (cdc.gov)
• Melisa Shah] Human coronaviruses occur primarily in the winter in temperate climates, although infections can occur at any time of year. (cdc.gov)
• For example, there's a study from Michigan that spanned eight seasons indicating that only 2.5% of infections with common human coronaviruses being identified between June and September. (cdc.gov)

Viral9

• camel flu' [1] ) er en viral [note 1] luftvejsinfektion forårsaget af MERS-CoV , MERS-coronavirus. (wikipedia.org)
• Coronaviruses earn their name from the characteristic crown-like viral particles (virions) that dot their surface. (ebmedicine.net)
• Our integrated analysis revealed that the viral transcripts (i.e. subgenomic mRNAs) generally fitted the expected transcription model for coronaviruses. (biomedcentral.com)
• Based on homology to other known coronaviruses [ 3 , 4 ], the genome sequence was used for viral transcript prediction and the annotation of ORFs. (biomedcentral.com)
• The polyproteins are post-translationally processed by viral encoded proteases to produce 16 proteins that are conserved between coronaviruses and proposed to function in the synthesis of viral RNA and immune evasion [ 8 ]. (biomedcentral.com)
• Brilacidin was shown to exert a dual-acting antiviral mechanism of action, able to target coronaviruses directly and bind to host cell surfaces to prevent viral entry. (biospace.com)
• The complementary viral protein of coronaviruses is called the spike protein, visible as the pillar-like projections on the virus's surface. (thewire.in)
• Hence, human coronaviruses antagonize the viral inhibitor p53 via stabilizing RCHY1 and promoting RCHY1-mediated p53 degradation. (cipsm.de)
• Chinese researchers isolated the virus and three days later shared data from the viral genome internationally, calling it a new Coronavirus 2 . (bvsalud.org)

Abstract1

• ABSTRACT A literature review of publically available information was undertaken to summarize current understanding and gaps in knowledge about Middle East respiratory syndrome coronavirus (MERS-CoV), including its origin, transmission, effective control measures and management. (who.int)

Respiratory Syndrome2

• For den virus der forsager den,, se Middle East respiratory syndrome-related coronavirus . (wikipedia.org)
• Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. (zombiemall.com)

Different types of coronaviruses2

• Are there different types of coronaviruses other than COVID-19? (scienceoxygen.com)
• Sarah Gregory] What are the different types of coronaviruses? (cdc.gov)

Alpha-coronaviruses2

• The neutralizing potential of serum directed towards the human alpha-coronavirus NL-63 (NL63) also waned, indicating that no cross-priming against alpha-coronaviruses occurred. (bvsalud.org)
• More severe disease is generally seen in infants and older adults, and one of the alpha coronaviruses (NL63) has been associated with croup in children. (cdc.gov)

Causing coronavirus disease1

• The virus causing coronavirus disease 2019 (COVID-19), is not the same as the coronaviruses that commonly circulate among humans and cause mild illness, like the common cold. (mmchs.org)

Identified in the mid-1960s1

• Human coronaviruses were first identified in the mid-1960s. (cdc.gov)

Species9

• In rare instances, a coronavirus that originates in animals may evolve or "jump species" to infect humans. (mdanderson.org)
• non-human and sHCoV (black arrows), within sHCoV species (blue arrows), and between sHCoV species (green arrows). (news-medical.net)
• Scientists suspect it jumped the species barrier twice - from bats to civet cats, and then from civet cats to humans. (thewire.in)
• However, scientists don't yet know if the cross-species jump happened directly from bats to humans or if there was an intermediate mammal. (thewire.in)
• They infect and produce disease in multiple species of animals, human beings (group 1 and 2) and birds (group 3). (scialert.net)
• The presence of the virus in animal species and an understanding of whether these are natural or recent human to animal transmissions is important. (preprints.org)
• Currently, at least seven coronavirus species are known to cause diseases in humans. (ijbs.com)
• This article is about a species of coronavirus comprising multiple strains. (wikizero.com)
• [17] [4] Both of these strains descended from a single ancestor but made the cross-species jump into humans separately. (wikizero.com)

Proteins2

• Maximum clade credibility (MCC) trees inferred from dataset D5 for full genomes (WGS), and the spike, nucleocapsid, membrane and envelope proteins, with the branches color-coded by the inferred coronavirus host. (news-medical.net)
• The coronaviruses are named so because they are distinguished by the high density of spike proteins. (thewire.in)

Disease8

• Here are seven things cancer patients should know about coronaviruses, including the novel coronavirus disease (COVID-19) that was first detected in Hubei province, China. (mdanderson.org)
• According to the Centers for Disease Control and Prevention (CDC), most people will get infected with one of these common types of coronavirus in their lifetime. (mdanderson.org)
• The Moderna COVID-19 vaccine has not been approved or licensed by the Food and Drug Administration, but it has been authorized for emergency use by the FDA under an emergency use authorization to prevent coronavirus disease 2019, for use in individuals 18 years of age and older. (wakingtimes.com)
• The present review highlights the salient features of the Coronavirus in general with special reference to ECV and the disease it causes in equines, its epidemiology, diagnosis and appropriate prevention and control measures to be adopted. (scialert.net)
• What is the origin of the coronavirus disease? (scienceoxygen.com)
• Where was the first case of the coronavirus disease observed? (scienceoxygen.com)
• When was the coronavirus disease first reported in Europe? (scienceoxygen.com)
• All human beings are susceptible to host this virus, however, those with comorbidities, chronic diseases and older than 60 years are more easily affected by the severity of the disease COVID-19. (bvsalud.org)

Recombinant2

• The use of recombinant human ACE2 (rhACE2) as ACE receptor competitor for binding has also been investigated ( 6 , 7 ). (frontiersin.org)
• Immunogen Recombinant human ACE2 produced in a mammalian expression system. (qedbio.com)

Animal coronaviruses1

• Are there animal coronaviruses and if so, can they be spread to people? (cdc.gov)

MERS3

• MERS-CoV er en coronavirus , der antages at stamme fra flagermus . (wikipedia.org)
• The MERS virus was found to have jumped from camels to humans. (thewire.in)
• RÉSUMÉ Une analyse documentaire des informations publiques disponibles a été entreprise afin de passer en revue les connaissances et les lacunes actuelles sur le coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV), notamment sur son origine, la transmission, les mesures de lutte efficaces et la prise en charge. (who.int)

Seasonal3

• The novel multiplex assay for real-time pan-coronavirus detection enhances respiratory virus diagnosis, overcomes potential diagnostic problems arising through seasonal variation in coronavirus frequency, and provides novel insights into the epidemiology and clinical implications of coronaviruses. (ed.ac.uk)
• Coronavirus NL63 has a seasonal association in temperate climates. (diastrip.com)
• They are sometimes referred to as the common cold or endemic or seasonal coronaviruses. (cdc.gov)

Syndrome respiratoire1

• Contexte: Pour contrôler la propagation de la maladie à coronavirus 19 (COVID-19) causée par le syndrome respiratoire aigu sévère coronavirus-2 (SRAS-CoV-2), il est nécessaire d'identifier et d'isoler de manière adéquate les patients infectieux, en particulier sur le lieu de travail. (bvsalud.org)

20222

• WAKEFIELD, MA / ACCESSWIRE / March 15, 2022 / Innovation Pharmaceuticals (OTCQB:IPIX) ("the Company"), a clinical stage biopharmaceutical company, today announced publication of a peer-review scientific article in the Journal of Medical Virology on the anti-coronavirus properties of Brilacidin. (biospace.com)
• Méthodologie: Entre septembre 2021 et février 2022, des écouvillonnages oropharyngés et/ou nasopharyngés de travailleurs symptomatiques COVID-19 et apparemment en bonne santé sélectionnés consécutivement du site minier de Wahgnion dans le sud-ouest du Burkina Faso qui ont consenti à l'étude ont été prélevés selon les deux programme de quart de semaines et testé pour le SRAS-CoV-2 à l'aide d'un test RT-PCR. (bvsalud.org)

Genome3

• Full genome sequences formed a monophyletic clade closely related to contemporary HCoV-NL63 from other global locations. (lshtm.ac.uk)
• The Coronavirus genome RNA molecule is 26 to 32 kb in size. (scialert.net)
• [20] SARSr-CoV is similar to other coronaviruses in that its genome expression starts with translation by the host cell's ribosomes of its initial two large overlapping open reading frames (ORFs), 1a and 1b, both of which produce polyproteins . (wikizero.com)

Pneumonia2

• Results: HCoV-NL63 was detected in 1.3% (75/5573) of child pneumonia admissions. (lshtm.ac.uk)
• Conclusions: In this coastal Kenya setting, HCoV-NL63 exhibited low prevalence in hospital pediatric pneumonia admissions. (lshtm.ac.uk)

20021

• From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. (cdc.gov)

Mild1

• In general, coronaviruses are named for their crown-like spikes on their surface, and the common human coronaviruses cause mild to moderate upper respiratory tract illness (like the common cold). (cdc.gov)

Protein6

• A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. (cdc.gov)
• We here reveal features of the coronavirus spike (S) protein, which optimize the virus towards different parts of the respiratory tract. (biorxiv.org)
• Collectively, our findings indicate how the coronavirus spike protein is fine-tuned towards the temperature and protease conditions of the airways, to enhance virus transmission and pathology. (biorxiv.org)
• HCoV-NL63 was detected with multiplex real-time reverse transcription PCR, and positive samples were targeted for nucleotide sequencing of the spike (S) protein. (lshtm.ac.uk)
• AngiotensinI-converting enzyme 2 (ACE 2) is a protein belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. (avivasysbio.com)
• Additionally, the new virus's spike also has a target site for another human protein called furin, which is made in nearly all cells of the body. (thewire.in)

Bats3

• On the contrary, autonomous transmissions of CoVs from bats to humans and camelids seemed to be more probable. (news-medical.net)
• Some coronaviruses cause cold-like illnesses in people, while others cause illness in certain types of animals, such as cattle, camels, and bats. (scienceoxygen.com)
• As you know, coronaviruses are also found in birds and mammals, with bats being hosts to many types. (cdc.gov)

Emergence1

• While all these factors described above are due to human activities, natural causes may also be important in emergence, such as climate change, floods, drought, famine and other natural disasters, and thus should not be forgotten or discounted. (who.int)

Infect people2

• What are the known coronaviruses that can infect people? (scienceoxygen.com)
• Some coronaviruses, such as canine and feline coronaviruses, infect only animals and do not infect people. (scienceoxygen.com)

Acute respiratory1

• Coronavirus NL63 appears mainly in young children, the elderly and immunocompromised patients with acute respiratory illness. (diastrip.com)

Multiplex real-time reverse1

• To address these problems, we conducted a large-scale comprehensive screening for all four coronaviruses by analysis of 11,661 diagnostic respiratory samples collected in Edinburgh, United Kingdom, over 3 years between July 2006 and June 2009 using a novel four-way multiplex real-time reverse transcription-PCR (RT-PCR) assay. (ed.ac.uk)

Symptoms2

• The first cultured human coronavirus (B814) was obtained from a boy with a typical common cold in 1965 and research and studies from that point on continued to find the virus mutating and appearing in different forms with various, but often similar, symptoms such as nasal congestion, fever and coughing. (as.com)
• Don't rely on an absence of typical symptoms to rule out coronavirus. (epmonthly.com)

Pathogens1

• Apes are the closest nonhuman primate relative of humans and are therefore susceptible to many human pathogens. (cdc.gov)

Common5

• No. It means you were likely exposed to one of the more common types of coronavirus, and it showed up in your blood tests. (mdanderson.org)
• Patients with COVID-19 will be evaluated and cared for differently than patients with common coronavirus diagnosis. (mmchs.org)
• We'll be discussing the seasonality of common human coronaviruses in the United States. (cdc.gov)
• And the four common human coronaviruses include two alpha types and two beta types. (cdc.gov)
• Sarah Gregory] You focused (in your article) on the seasonality of common human coronaviruses in the US from 2014 to 2021. (cdc.gov)

Transmission2

• Transmission of HCoV-NL63 is likely through droplet expulsion from the respiratory tract, which may be cottages when close personal contact occurs. (diastrip.com)
• The transmission of the coronavirus occurs between humans, and it can occur from person to person through the air, through coughing or sneezing, by touching or shaking hands or by contact with contaminated objects or surfaces, followed by contact with the mouth, nose or eyes. (bvsalud.org)