Coronavirus NL63, Human
Coronavirus
Coronavirus Infections
Coronavirus 229E, Human
Respiratory Tract Infections
Spike Glycoprotein, Coronavirus
Coronavirus, Bovine
SARS Virus
Coronavirus OC43, Human
Coronavirus, Feline
Coronaviridae
Coronavirus, Canine
Severe Acute Respiratory Syndrome
Murine hepatitis virus
Transmissible gastroenteritis virus
Infectious bronchitis virus
Nucleocapsid Proteins
Coronavirus, Rat
Respiratory Syncytial Virus Infections
Croup
Laryngitis
Tracheitis
Herpesvirus 1, Gallid
Differentiation between human coronaviruses NL63 and 229E using a novel double-antibody sandwich enzyme-linked immunosorbent assay based on specific monoclonal antibodies. (1/17)
(+info)Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells. (2/17)
(+info)Human rhinovirus infection in young African children with acute wheezing. (3/17)
(+info)A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses. (4/17)
(+info)Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications. (5/17)
(+info)The dominance of human coronavirus OC43 and NL63 infections in infants. (6/17)
(+info)Epidemiology of coronavirus-associated respiratory tract infections and the role of rapid diagnostic tests: a prospective study. (7/17)
1. Coronaviruses accounted for 1.6% (98/6272) of respiratory tract infections based on nasopharyngeal aspirate samples. 2. HCoV-OC43 was the most common coronavirus detected,followed by HCoV-NL63, CoVHKU1,and HCoV-229E. 3. Although CoV-HKU1 infections were most often associated with the upper respiratory tract, more severe illness (pneumonia,acute bronchiolitis, and asthmatic exacerbation) may occur, especially in those with underlying disease. In young children, CoV-HKU1 infection is associated with a high rate of febrile seizures (50%). 4. CoV-HKU1 and HCoV-OC43 infections peaked in winter, in contrast to HCoV-NL63, which mainly occurred in early summer and autumn, but was absent in winter. 5. Reverse transcriptase polymerase chain reaction is useful for the rapid diagnosis of coronavirus infections. (+info)Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity. (8/17)
1. Human coronaviruses (HCoVs)were detected in 2.5% of 2982 local children hospitalised for acute respiratory infections in 2005 to 2007. 2. Using the 'pancoronavirus' reverse transcription-polymerase chain reaction assay, detection rates were 0.6% for HCoVNL63,1.2% for HCoV-OC43,0.5% for HCoV-HKU1, and 0.2% for HCoV-229E. Notably, HCoV-NL63 infections were significantly more common among children hospitalised in 2006/2007 (1.2%) than in 2005/2006 (0.3%).3. The peak season for HCoVNL63 infection was autumn(September to October). 4. HCoV-NL63 infection was associated with younger age,croup, febrile convulsion, and acute gastroenteritis. Such disease associations were not found with the other three HCoVs. 5. Most local HCoV-NL63 isolates were closely related to the prototype strain in Netherlands(NL496), but a few were phylogenetically distinct from the major cluster. (+info)Human coronavirus NL63 (HCoV-NL63) is a single-stranded RNA virus that belongs to the family Coronaviridae and the genus Alphacoronavirus. It was first identified in 2004 in a child with bronchiolitis and conjunctivitis in the Netherlands.
HCoV-NL63 is responsible for causing respiratory tract infections, ranging from mild upper respiratory symptoms to severe lower respiratory tract illnesses such as pneumonia and bronchiolitis. The virus is transmitted through respiratory droplets and direct contact with infected individuals.
The incubation period of HCoV-NL63 ranges from 2 to 14 days, and the symptoms typically last for 7 to 10 days. In addition to respiratory symptoms, HCoV-NL63 has been associated with febrile seizures, Kawasaki disease, and croup in children.
There is no specific treatment or vaccine available for HCoV-NL63 infection, and management is primarily supportive. Preventive measures such as hand hygiene, wearing masks, and social distancing can help reduce the transmission of the virus.
A coronavirus is a type of virus that causes respiratory illnesses, such as the common cold, and more severe diseases including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). These viruses are typically spread through close contact with an infected person when they cough or sneeze. They can also spread by touching a surface or object that has the virus on it and then touching your own mouth, nose, or eyes.
Coronaviruses are named for the crown-like spikes on their surface. They are zoonotic, meaning they can be transmitted between animals and people. Common signs of infection include fever, cough, and shortness of breath. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.
One of the most recently discovered coronaviruses is SARS-CoV-2, which causes the disease COVID-19. This virus was first identified in Wuhan, China in late 2019 and has since spread to become a global pandemic.
Coronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases such as pneumonia. The name "coronavirus" comes from the Latin word "corona," which means crown or halo, reflecting the distinctive appearance of the virus particles under electron microscopy, which have a crown-like structure due to the presence of spike proteins on their surface.
Coronaviruses are zoonotic, meaning they can be transmitted between animals and humans. Some coronaviruses are endemic in certain animal populations and occasionally jump to humans, causing outbreaks of new diseases. This is what happened with Severe Acute Respiratory Syndrome (SARS) in 2002-2003, Middle East Respiratory Syndrome (MERS) in 2012, and the most recent Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2.
Coronavirus infections typically cause respiratory symptoms such as cough, shortness of breath, and fever. In severe cases, they can lead to pneumonia, acute respiratory distress syndrome (ARDS), and even death, especially in older adults or people with underlying medical conditions. Other symptoms may include fatigue, muscle aches, headache, sore throat, and gastrointestinal issues such as nausea, vomiting, and diarrhea.
Preventive measures for coronavirus infections include frequent hand washing, wearing face masks, practicing social distancing, avoiding close contact with sick individuals, and covering the mouth and nose when coughing or sneezing. There are currently vaccines available to prevent COVID-19, which have been shown to be highly effective in preventing severe illness, hospitalization, and death from the disease.
Human coronavirus 229E (HCoV-229E) is a species of coronavirus that causes respiratory infections in humans. It is one of the several coronaviruses known to cause the common cold. HCoV-229E was first identified in the 1960s and is named after the number assigned to it in the laboratory where it was discovered.
HCoV-229E infects the human body through the respiratory tract, and it primarily affects the upper respiratory system, causing symptoms such as runny nose, sore throat, cough, and fever. In some cases, HCoV-229E can also cause lower respiratory infections, such as pneumonia, especially in individuals with weakened immune systems or underlying medical conditions.
HCoV-229E is an enveloped, positive-sense, single-stranded RNA virus that belongs to the family Coronaviridae and the genus Alphacoronavirus. It is transmitted through respiratory droplets produced when an infected person coughs, sneezes, or talks. The virus can also survive on surfaces for several hours, making it possible to contract the infection by touching contaminated objects.
There is no specific treatment for HCoV-229E infections, and most people recover within a week or two with rest and symptomatic relief. However, severe cases may require hospitalization and supportive care, such as oxygen therapy and mechanical ventilation. Preventive measures, such as hand hygiene, wearing masks, and avoiding close contact with infected individuals, can help reduce the transmission of HCoV-229E and other respiratory viruses.
Respiratory tract infections (RTIs) are infections that affect the respiratory system, which includes the nose, throat (pharynx), voice box (larynx), windpipe (trachea), bronchi, and lungs. These infections can be caused by viruses, bacteria, or, less commonly, fungi.
RTIs are classified into two categories based on their location: upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs). URTIs include infections of the nose, sinuses, throat, and larynx, such as the common cold, flu, laryngitis, and sinusitis. LRTIs involve the lower airways, including the bronchi and lungs, and can be more severe. Examples of LRTIs are pneumonia, bronchitis, and bronchiolitis.
Symptoms of RTIs depend on the location and cause of the infection but may include cough, congestion, runny nose, sore throat, difficulty breathing, wheezing, fever, fatigue, and chest pain. Treatment for RTIs varies depending on the severity and underlying cause of the infection. For viral infections, treatment typically involves supportive care to manage symptoms, while antibiotics may be prescribed for bacterial infections.
A spike glycoprotein in coronaviruses is a type of protein that extends from the surface of the virus and gives it its characteristic crown-like appearance (hence the name "corona," which is Latin for "crown"). This protein plays a crucial role in the infection process of the virus. It allows the virus to attach to and enter specific cells in the host organism, typically through binding to a receptor on the cell surface. In the case of SARS-CoV-2, the coronavirus responsible for COVID-19, the spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor found on cells in various tissues, including the lungs, heart, and gastrointestinal tract.
The spike protein is composed of two subunits: S1 and S2. The S1 subunit contains the receptor-binding domain (RBD), which recognizes and binds to the host cell receptor. After binding, the S2 subunit mediates the fusion of the viral membrane with the host cell membrane, allowing the viral genome to enter the host cell and initiate infection.
The spike protein is also a primary target for neutralizing antibodies generated by the host immune system during infection or following vaccination. Neutralizing antibodies bind to specific regions of the spike protein, preventing it from interacting with host cell receptors and thus inhibiting viral entry into cells.
In summary, a spike glycoprotein in coronaviruses is a crucial structural and functional component that facilitates viral attachment, fusion, and entry into host cells. Its importance in the infection process makes it an essential target for vaccine development and therapeutic interventions.
Bovine coronavirus (BCoV) is a species of coronavirus that infects cattle and other animals such as yaks, deer, and occasionally humans. It is an enveloped, single-stranded, positive-sense RNA virus belonging to the genus Betacoronavirus in the family Coronaviridae.
BCoV primarily causes respiratory and enteric diseases in cattle, resulting in symptoms such as pneumonia, coughing, diarrhea, and decreased appetite. The virus is transmitted through direct contact with infected animals or their feces, contaminated food, water, or fomites.
In humans, BCoV infection is rare but has been associated with respiratory illnesses in people working closely with cattle, such as farmers, abattoir workers, and veterinarians. The symptoms of human BCoV infection are similar to those caused by other coronaviruses, including fever, cough, and shortness of breath.
Prevention measures for BCoV include good hygiene practices, wearing personal protective equipment when working with cattle, and vaccination of animals against the virus. There is currently no specific treatment or vaccine available for human BCoV infection.
Severe Acute Respiratory Syndrome (SARS) is a viral respiratory illness caused by the SARS coronavirus (SARS-CoV). This virus is a member of the Coronaviridae family and is thought to be transmitted most readily through close person-to-person contact via respiratory droplets produced when an infected person coughs or sneezes.
The SARS outbreak began in southern China in 2002 and spread to several other countries before it was contained. The illness causes symptoms such as fever, chills, and body aches, which progress to a dry cough and sometimes pneumonia. Some people also report diarrhea. In severe cases, the illness can cause respiratory failure or death.
It's important to note that SARS is not currently a global health concern, as there have been no known cases since 2004. However, it remains a significant example of how quickly and widely a new infectious disease can spread in today's interconnected world.
Human coronavirus OC43 (HCoV-OC43) is a species of coronavirus that causes respiratory infections in humans. It is one of the several coronaviruses known to cause the common cold. HCoV-OC43 belongs to the genus Betacoronavirus and is an enveloped, positive-sense, single-stranded RNA virus.
The virus was first identified in 1967 and has since been found to be widely distributed throughout the human population. It is estimated that HCoV-OC43 infections occur annually, with a peak incidence during the winter months in temperate climates. The symptoms of HCoV-OC43 infection are typically mild and include nasal congestion, runny nose, sore throat, and cough.
HCoV-OC43 is transmitted through respiratory droplets produced when an infected person talks, coughs, or sneezes. The virus can also be spread by touching contaminated surfaces and then touching the mouth, nose, or eyes. There is no specific treatment for HCoV-OC43 infections, and management is generally supportive, with rest, hydration, and symptomatic relief of fever and cough.
HCoV-OC43 has been identified as one of the coronaviruses that have the potential to cause severe respiratory illness in immunocompromised individuals or those with underlying medical conditions. However, most HCoV-OC43 infections are mild and do not require hospitalization.
Feline coronavirus (FCoV) is a type of virus that primarily infects cats. It is part of the Coronaviridae family and has a positive-sense, single-stranded RNA genome. There are two types of feline coronavirus: feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV).
FECV is a relatively harmless virus that primarily causes mild to no symptoms in infected cats, and it is spread through fecal-oral transmission. FECV mainly affects the intestines and can cause diarrhea in some cases.
FIPV, on the other hand, is a mutated form of FECV that can cause a severe and often fatal disease called feline infectious peritonitis (FIP). FIP is an immune-mediated disease characterized by inflammation and accumulation of fluid in the abdomen or chest. It can also affect other organs, such as the eyes, brain, and liver.
It's important to note that not all cats infected with FECV will develop FIP. The development of FIP depends on various factors, including the cat's age, immune system, and the specific strain of the virus. There is no cure for FIP, but supportive care can help manage the symptoms and improve the cat's quality of life.
Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. They are named for the crown-like (corona) appearance of their surface proteins. Coronaviruses infect a wide range of animals, including mammals and birds, and can cause respiratory, gastrointestinal, and neurological diseases. Some coronaviruses, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), can cause severe and potentially fatal illness in humans. The most recent example is SARS-CoV-2, which causes COVID-19.
Canine coronavirus (CCoV) is a species of coronavirus that infects dogs. It is related to the coronaviruses that cause respiratory illness in humans, such as SARS-CoV and MERS-CoV, but it is not known to infect people. CCoV primarily affects the gastrointestinal tract and can cause symptoms such as vomiting and diarrhea. It is usually spread through contact with infected feces. There are two main types of CCoV, called Type I and Type II, which are classified based on their genetic makeup. Both types can cause illness in dogs, but Type II is more likely to cause severe disease. Vaccines are available to help protect dogs against CCoV infection.
Severe Acute Respiratory Syndrome (SARS) is a viral respiratory illness characterized by fever, cough, shortness of breath, and sometimes severe pneumonia. It is caused by the SARS coronavirus (SARS-CoV).
The syndrome is considered severe due to its potential to cause rapid spread in communities and healthcare settings, and for its high case fatality rate. In the global outbreak of 2002-2003, approximately 8,000 people were infected and nearly 800 died. Since then, no large outbreaks have been reported, although there have been isolated cases linked to laboratory accidents or animal exposures.
SARS is transmitted through close contact with an infected person's respiratory droplets, such as when they cough or sneeze. It can also be spread by touching a surface contaminated with the virus and then touching the mouth, nose, or eyes. Healthcare workers and others in close contact with infected individuals are at higher risk of infection.
Preventive measures include good personal hygiene, such as frequent handwashing, wearing masks and other protective equipment when in close contact with infected individuals, and practicing respiratory etiquette (covering the mouth and nose when coughing or sneezing). Infected individuals should be isolated and receive appropriate medical care to help manage their symptoms and prevent transmission to others.
Coronaviridae is a family of enveloped, positive-sense RNA viruses that cause various diseases in animals and humans. Human coronavirus infections most commonly result in mild to moderate upper respiratory tract illnesses, such as the common cold. However, two highly pathogenic coronaviruses have emerged in the past two decades: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). These viruses can cause severe and potentially fatal respiratory illnesses.
In general, coronaviruses are transmitted through respiratory droplets produced when an infected person coughs, sneezes, or talks. In some cases, people may become infected by touching a surface contaminated with the virus and then touching their mouth, nose, or eyes. Preventive measures include frequent handwashing, avoiding close contact with sick individuals, and practicing good respiratory etiquette (e.g., covering coughs and sneezes).
Treatment for coronavirus infections is primarily supportive, focusing on relieving symptoms and managing complications. For severe cases of SARS-CoV and MERS-CoV infections, antiviral medications and supportive care in an intensive care unit may be necessary. Vaccines have been developed to protect against SARS-CoV-2, the virus that causes COVID-19, and are being distributed globally.
Murine hepatitis virus (MHV) is a type of coronavirus that primarily infects laboratory mice. It is not related to the human hepatitis viruses A, B, C, D, or E. MHV causes a range of diseases in mice, including hepatitis (liver inflammation), encephalomyelitis (inflammation of the brain and spinal cord), and enteritis (inflammation of the intestine). The virus is transmitted through fecal-oral route and respiratory droplets. It's widely used in research to understand the pathogenesis, immunity, and molecular biology of coronaviruses.
Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that primarily affects the pig's intestinal tract, causing severe diarrhea, vomiting, and dehydration. The infection is highly contagious and can lead to significant mortality in young piglets. TGEV is transmitted through the fecal-oral route and can also be spread by contaminated fomites or aerosols. It primarily infects enterocytes in the small intestine, leading to villous atrophy and malabsorption of nutrients. There are no specific antiviral treatments for TGEV infection, and control measures typically focus on biosecurity, vaccination, and preventing the spread of the virus between herds.
Infectious Bronchitis Virus (IBV) is a single-stranded, enveloped RNA virus belonging to the genus Gammacoronavirus and family Coronaviridae. It is the causative agent of infectious bronchitis (IB), a highly contagious respiratory disease in birds, particularly in chickens. The virus primarily affects the upper respiratory tract, causing tracheitis, bronchitis, and sinusitis. In addition to respiratory issues, IBV can also lead to decreased egg production, poor growth rates, and impaired immune response in infected birds. Several serotypes and variants of IBV exist worldwide, making vaccine development and disease control challenging.
Nucleocapsid proteins are structural proteins that are associated with the viral genome in many viruses. They play a crucial role in the formation and stability of the viral particle, also known as the virion. In particular, nucleocapsid proteins bind to the viral RNA or DNA genome and help to protect it from degradation by host cell enzymes. They also participate in the assembly and disassembly of the virion during the viral replication cycle.
In some viruses, such as coronaviruses, the nucleocapsid protein is also involved in regulating the transcription and replication of the viral genome. The nucleocapsid protein of SARS-CoV-2, for example, has been shown to interact with host cell proteins that are involved in the regulation of gene expression, which may contribute to the virus's ability to manipulate the host cell environment and evade the immune response.
Overall, nucleocapsid proteins are important components of many viruses and are often targeted by antiviral therapies due to their essential role in the viral replication cycle.
A coronavirus that primarily infects rats is called "rat coronavirus." It is a type of virus that belongs to the genus Betacoronavirus, which also includes coronaviruses that can infect humans, such as SARS-CoV and MERS-CoV.
Rat coronavirus is closely related to coronaviruses that infect mice and can cause respiratory illness in rats. It is typically transmitted through direct contact with infected rats or their feces and urine. Rat coronavirus infection is not known to spread to humans or other animals outside of laboratory settings.
It's worth noting that the current global pandemic is caused by a novel coronavirus called SARS-CoV-2, which is distinct from rat coronavirus and other known coronaviruses that infect animals.
Respiratory Syncytial Virus (RSV) infections refer to the clinical illnesses caused by the Respiratory Syncytial Virus. RSV is a highly contagious virus that spreads through respiratory droplets, contact with infected surfaces, or direct contact with infected people. It primarily infects the respiratory tract, causing inflammation and damage to the cells lining the airways.
RSV infections can lead to a range of respiratory illnesses, from mild, cold-like symptoms to more severe conditions such as bronchiolitis (inflammation of the small airways in the lungs) and pneumonia (infection of the lung tissue). The severity of the infection tends to depend on factors like age, overall health status, and presence of underlying medical conditions.
In infants and young children, RSV is a leading cause of bronchiolitis and pneumonia, often resulting in hospitalization. In older adults, people with weakened immune systems, and those with chronic heart or lung conditions, RSV infections can also be severe and potentially life-threatening.
Symptoms of RSV infection may include runny nose, cough, sneezing, fever, wheezing, and difficulty breathing. Treatment typically focuses on managing symptoms and providing supportive care, although hospitalization and more aggressive interventions may be necessary in severe cases or for high-risk individuals. Preventive measures such as hand hygiene, wearing masks, and avoiding close contact with infected individuals can help reduce the spread of RSV.
Croup is a common respiratory condition that mainly affects young children. It is characterized by a harsh, barking cough and difficulty breathing, which can sometimes be accompanied by stridor (a high-pitched, wheezing sound that occurs when breathing in). Croup is typically caused by a viral infection that leads to inflammation of the upper airway, including the larynx (voice box) and trachea (windpipe).
The medical definition of croup is:
* Acute laryngotracheitis or laryngotracheobronchitis
* Inflammation of the larynx and trachea, often with involvement of the bronchi
* Characterized by a barking cough, stridor, and hoarseness
* Most commonly caused by viral infections, such as parainfluenza virus
* Typically affects children between 6 months and 3 years of age.
Laryngitis is a medical condition characterized by inflammation of the larynx, or voice box. This inflammation can lead to hoarseness, throat pain, and difficulty speaking or swallowing. Laryngitis can be caused by viral infections, bacterial infections, vocal strain, or other factors such as exposure to irritants like smoke or chemicals. In some cases, laryngitis may be a symptom of a more serious underlying condition, so it is important to seek medical attention if symptoms persist for more than a few days or are accompanied by other concerning symptoms.
Tracheitis is a medical condition that involves inflammation of the trachea, or windpipe. It can cause symptoms such as cough, sore throat, difficulty swallowing, and fever. Tracheitis can be caused by viral or bacterial infections, and it may also occur as a complication of other respiratory conditions. In some cases, tracheitis may require medical treatment, including antibiotics for bacterial infections or corticosteroids to reduce inflammation. It is important to seek medical attention if you experience symptoms of tracheitis, especially if they are severe or persistent.
Gallid herpesvirus 1 (GaHV-1), also known as Marek's disease virus (MDV), is a member of the Herpesviridae family and specifically the Alphaherpesvirinae subfamily. It is a double-stranded DNA virus that primarily infects chickens and causes Marek's disease, a highly contagious neoplastic disease characterized by T-cell lymphomas in various organs of the chicken.
The virus is transmitted through the respiratory route and establishes latency in CD4+ T-lymphocytes. GaHV-1 has a complex genome, encoding for more than 100 open reading frames (ORFs), including several virulence factors that contribute to its oncogenic properties.
GaHV-1 infection can lead to various clinical manifestations, such as neurological signs, paralysis, and immunosuppression, in addition to the development of tumors. Vaccination is an effective control measure against Marek's disease, although new strains with increased virulence have emerged, requiring continuous monitoring and vaccine development efforts.
Viral diseases are illnesses caused by the infection and replication of viruses in host organisms. These infectious agents are obligate parasites, meaning they rely on the cells of other living organisms to survive and reproduce. Viruses can infect various types of hosts, including animals, plants, and microorganisms, causing a wide range of diseases with varying symptoms and severity.
Once a virus enters a host cell, it takes over the cell's machinery to produce new viral particles, often leading to cell damage or death. The immune system recognizes the viral components as foreign and mounts an immune response to eliminate the infection. This response can result in inflammation, fever, and other symptoms associated with viral diseases.
Examples of well-known viral diseases include:
1. Influenza (flu) - caused by influenza A, B, or C viruses
2. Common cold - usually caused by rhinoviruses or coronaviruses
3. HIV/AIDS - caused by human immunodeficiency virus (HIV)
4. Measles - caused by measles morbillivirus
5. Hepatitis B and C - caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively
6. Herpes simplex - caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2)
7. Chickenpox and shingles - both caused by varicella-zoster virus (VZV)
8. Rabies - caused by rabies lyssavirus
9. Ebola - caused by ebolaviruses
10. COVID-19 - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Prevention and treatment strategies for viral diseases may include vaccination, antiviral medications, and supportive care to manage symptoms while the immune system fights off the infection.
Racepinephrine is not typically referred to as a "race" in the medical context, but rather as a form of epinephrine (also known as adrenaline). Racepinephrine is the optical isomer of epinephrine, meaning that it is a molecule with the same chemical formula but a different arrangement of atoms in space.
Racepinephrine is a naturally occurring catecholamine, a type of neurotransmitter and hormone that is produced by the adrenal glands and is involved in the "fight or flight" response. It is also used as a medication, typically in the form of the racemic mixture of epinephrine, which contains equal amounts of both isomers (R- and S-epinephrine).
Racepinephrine has similar effects to epinephrine, including increasing heart rate and blood pressure, improving respiratory function, and enhancing mental alertness. It is used in the treatment of anaphylaxis, cardiac arrest, and other emergency situations where rapid restoration of cardiovascular function is necessary.
It's important to note that while racepinephrine and epinephrine have similar effects, they are not identical and may have different therapeutic uses and potential side effects.
Human coronavirus NL63
Coronavirus diseases
Human coronavirus 229E
List of epidemics and pandemics
History of coronavirus
Coronavirus spike protein
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Coronavirus membrane protein
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2012 MERS outbreak
Angiotensin-converting enzyme 2
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List of Coronavirus live isolates
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Human coronavirus NL63 - Wikipedia
Human Coronavirus NL63, France - Volume 11, Number 8-August 2005 - Emerging Infectious Diseases journal - CDC
Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China
The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
Human Coronavirus Types | CDC
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection | Nature Immunology
IUCr) Acta Crystallographica Section F Volume 70, Part 8, August 2014
Croup: Background, Epidemiology
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Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection | PLOS ONE
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Frontiers | Effectiveness of Surgical Face Masks in Reducing Acute Respiratory Infections in Non-Healthcare Settings: A...
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To Vaccinate or Not---The Rat Flu Odyssey Continues
The Respiratory Protection Effectiveness Clinical Trial (ResPECT): a cluster-randomized comparison of respirator and medical...
Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA | Nature Biomedical Engineering
Evolutionary and Computational Virology - Fogarty International Center @ NIH
Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)
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229E15
- The evolution of HCoV-NL63 appears to have involved recombination between an ancestral NL63-like virus circulating in African Triaenops afer bats and a CoV 229E-like virus circulating in Hipposideros bats. (wikipedia.org)
- An early study investigating children with lower respiratory tract illness, found that HCoV-NL63 was more commonly found in outpatients than hospitalized patients, suggesting that it is a common cold virus similar to HCoV-229E and HCoV-OC43, which generally cause less severe symptoms. (wikipedia.org)
- Phylogenetic analysis showed that HCoV-NL63 is a new group 1 coronavirus, most closely related to HCoV-229E. (cdc.gov)
- Samples were also tested for human metapneumovirus (HMPV), rhinovirus, enterovirus, and HCoV 229E and OC43 by virus isolation and RT-PCR. (cdc.gov)
- People around the world commonly get infected with human coronaviruses 229E, NL63, OC43, and HKU1. (cdc.gov)
- These comprise the Beta-coronaviruses OC43 and HKU-1, which have 38% and 35% amino acid homology with SARS-CoV-2, and the more distantly related Alpha-coronaviruses NL63 and 229E, each with around 31% homology 11 . (nature.com)
- The following surveillance information only includes four common human coronavirus types (229E, NL63, OC43, and HKU1), not SARS-CoV2 the virus that causes COVID-19. (cdc.gov)
- They were caused by coronaviruses 229E, NL63 and OC43, influenza B virus, respiratory syncytial virus A, rhinovirus and human metapneumovirus. (bmj.com)
- A diagnosis with coronavirus 229E, NL63, OC43, or HKU1 is not the same as a COVID-19 diagnosis. (yakimacounty.us)
- In a recent study posted to the bioRxiv * preprint server, researchers investigated whether immunity against seasonal human coronavirus (CoV) spike (S) proteins of HKU1, OC43, NL63, or 229E could protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro . (news-medical.net)
- Mice were vaccinated with NL63, 229E, OC43, HKU1, and SARS-CoV-2 S proteins in prime-boost regimens. (news-medical.net)
- 229E S-vaccinated mice sera reacted robustly with 229E S, whereas activity against NL63 S was lowered, and no activity was observed among the three beta-CoV S. NL63 S appeared to be marginally less immunogenic and generated comparable titers indicating strong activity against the homologous S, lesser reactivity to 229E S and some, although lowered reactivity to β-CoV S. (news-medical.net)
- You've likely never heard of coronaviruses 229E, NL63, OC43, and HKU1, but your immune system knows them well. (24hrcares.com)
- Coronaviruses 229E, OC43, NL63, and HKU1 cause about 15 to 30% of cases of the common cold. (msdmanuals.com)
- Most people are infected with common coronaviruses throughout their lives, but only four of them cause common cold symptoms: alpha coronavirus 229E and NL63 and beta coronavirus OC43, HKU1 (V) 1 . (bvsalud.org)
HKU17
- In 2004, the increase in research on theses viruses soon led to the discovery of 2 other human coronaviruses, HCoV-NL63 in the Netherlands and, more recently, CoV-HKU1 in China ( 1 - 3 ). (cdc.gov)
- The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI). (hindawi.com)
- Thirty-two (8.4%) and 57 (14.9%) of 382 specimens tested positive for HCoV-NL63 and HCoV-HKU1, respectively, by real-time RT-PCR. (hindawi.com)
- Phylogenetic studies showed that the HCoV-HKU1 nucleoprotein gene was relatively conserved compared to NCBI reference sequences, while the 1ab gene of HCoV-NL63 showed more variation. (hindawi.com)
- The outbreak of SARS renewed interest in this virus family and resulted in the identification of two additional HCoVs, HCoV-NL63 and HCoV-HKU1. (hindawi.com)
- In China, several groups have demonstrated the existence of HCoV-NL63 and HCoV-HKU1 as potential respiratory pathogens of infants and the elderly [ 3 - 5 ]. (hindawi.com)
- In this study, we screened for the presence of HCoV-NL63 and HCoV-HKU1 in children with acute respiratory infection admitted to the Beijing Children's Hospital in an effort to gain a better understanding of the seasonality, epidemiology and genetic diversity of these viruses in a city with a population of more than 22 million. (hindawi.com)
HCoV-NL6331
- Human coronavirus NL63 (HCoV-NL63) is a species of coronavirus, specifically a Setracovirus from among the Alphacoronavirus genus. (wikipedia.org)
- A study performed in Amsterdam estimated the presence of HCoV-NL63 in approximately 4.7% of common respiratory illnesses. (wikipedia.org)
- The first cases of the infection with HCoV-NL63 were found in young children with severe lower respiratory tract infections admitted to hospitals. (wikipedia.org)
- The comorbidity of HCoV-NL63 with other respiratory infections, has made the specific symptoms of the virus difficult to pinpoint. (wikipedia.org)
- However, the high frequency of croup is specific to HCoV-NL63 infection. (wikipedia.org)
- It is believed that the route of HCoV-NL63 spread is through direct person-to-person transmission in highly populated areas. (wikipedia.org)
- Most people will be infected with a coronavirus in their lifetime, but some populations are more susceptible to HCoV-NL63. (wikipedia.org)
- Many studies have reported the co-occurrence of HCoV-NL63 with other human coronavirus, Influenza A virus, Human orthopneumovirus (RSV), parainfluenza virus, and Human metapneumovirus (hMPV). (wikipedia.org)
- As HCoV-NL63 infects the respiratory tract it must be inhaled to get there, and is therefore transmitted by the airborne route. (wikipedia.org)
- It is difficult to distinguish between symptoms caused by infection of the HCoV-NL63 virus and those caused by other common human viruses, making diagnosis and detection complex. (wikipedia.org)
- The United States Centers for Disease Control and Prevention (CDC) recommends several measures for the prevention of infection with HCoV-NL63 including: washing hands often with soap and water, avoiding close contact with sick individuals, and not touching the eyes, mouth, or nose. (wikipedia.org)
- Treatment for the HCoV-NL63 virus is dependent on the severity of associated symptomology. (wikipedia.org)
- The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been investigated. (cdc.gov)
- We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. (cdc.gov)
- From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. (cdc.gov)
- Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. (cdc.gov)
- A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. (cdc.gov)
- isolated HCoV-NL63 from a nasopharyngeal aspirate taken from a 7-month-old child hospitalized with bronchiolitis, conjunctivitis, and fever ( 1 ). (cdc.gov)
- Partial HCoV-NL63 sequences from Australia, Japan, and Canada have been submitted to the GenBank database, which indicates that this virus is distributed worldwide. (cdc.gov)
- Two retrospective studies were conducted in the Netherlands, and 11 additional HCoV-NL63-positive samples were detected from November 2000 to February 2003. (cdc.gov)
- We tested for HCoV-NL63 in children with acute respiratory tract infection hospitalized in Caen from November 2002 to April 2003, described symptoms associated with this infection, and examined local strains for the genetic variability. (cdc.gov)
- Of the 871 negative samples, 300 (50 per month) were tested for HCoV-NL63. (cdc.gov)
- Data for 18 patients with recorded HCoV-NL63 infection were available and were examined retrospectively for specific respiratory symptoms. (cdc.gov)
- In HCoV-NL63-infected patients they were cough, fever, and rhinorrhea. (hindawi.com)
- HCoV-NL63, a member of the group I coronaviruses, was first detected in a child with bronchiolitis in The Netherlands in 2004 [ 1 ]. (hindawi.com)
- In 2004, human coronavirus NL63 (HCoV-NL63) was discovered by researchers from The Netherlands. (uwc.ac.za)
- HCoV-NL63 has been indicated to cause both mild upper and more serious, but less common, lower respiratory tract infections and are commonly associated with other respiratory viruses in co-infections that can increase the severity of HCoV-NL63 infection. (uwc.ac.za)
- The nucleocapsid (N) protein of HCoV-NL63 is a multifunctional phosphoprotein that modulates the assembly of the ribonucleocapsid core of mature virions. (uwc.ac.za)
- For this reason, N protein was used to generate antibodies against an immune response to the presence of HCoV-NL63 N protein in mouse blood serum. (uwc.ac.za)
- HCoV-NL63 is a coronavirus that infects the respiratory system without causing cardiac injury, although its spike protein also uses ACE2 to mediate virus entry. (sciencedaily.com)
- Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63. (avivasysbio.com)
Including coronavirus disease 20191
- In the absence of pharmaceutical interventions such as vaccine and anti-virals for most respiratory viruses including coronavirus disease 2019 (COVID-19) ( 7 ), non-pharmaceutical interventions such as personal protection equipment are crucial to curb community spread ( 7 ). (frontiersin.org)
Metapneumovirus3
- Most pathogens were human metapneumovirus (25.4%, 54 cases), rhinovirus (16.4%, 35 cases) and Mycoplasma pneumoniae (13.1%, 23 cases). (who.int)
- Human metapneumovirus, human coronavirus (but not NL63) and M. pneumoniae were detected in almost all age groups without any significant bias. (who.int)
- Seasonal human coronaviruses, human metapneumovirus, M. pneumoniae and several other pathogens were detected until April 2020. (who.int)
Adenovirus1
- After 21 days of booster vaccinations, mice were intranasally transduced with non-replicating adenovirus-expressing hACE2 (human angiotensin-converting enzyme 2) followed by SARS-CoV-2 wild-type (wt) Washington-1 strain challenge after five days. (news-medical.net)
Pandemic3
- One of the emerging long-term impacts of the coronavirus disease 2019 (COVID-19) pandemic is persistent complications in organ systems other than the respiratory system, such as the nervous system. (news-medical.net)
- The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, the cause of coronavirus disease 2019 (COVID-19), has been responsible for the largest respiratory illness pandemic since the influenza pandemic of 1918. (health.mil)
- During the coronavirus disease pandemic in Japan, all patients with respiratory symptoms were initially tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (who.int)
Infections15
- It is now recognized that both these viruses have a worldwide circulation and are associated with human respiratory tract infections. (hindawi.com)
- These coronaviruses cause frequent mild childhood infections and antibody seroconversion occurs typically before the age of 5 years. (nature.com)
- In the United States, annual community outbreaks of coronavirus infections typically occur during late fall and winter. (cdc.gov)
- Viral infections continue to appear in human and wildlife populations, causing frequent epidemics and occasional pandemics. (nih.gov)
- This group of viruses cause enteric or respiratory tract infections in a variety of animals including humans, livestock and pets. (nhbs.com)
- False-positive results may occur due to cross reaction with circulating human coronaviruses that can account for up to 10-20% of viral respiratory infections (e.g. (snohd.org)
- Human coronaviruses were discovered in the 1960s by researchers studying the etiology of upper respiratory infections (URIs) in children and young adults. (thieme-connect.com)
- More severe lower respiratory infections (LRIs) were associated with the recent zoonotic crossovers of the severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) identified in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012. (thieme-connect.com)
- Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)
- These coronaviruses that cause severe respiratory infections are zoonotic pathogens, which begin in infected animals and are transmitted from animals to people. (msdmanuals.com)
- Melisa Shah] Generally, the common human coronaviruses can cause upper respiratory tract infections. (cdc.gov)
- Melisa Shah] Human coronaviruses occur primarily in the winter in temperate climates, although infections can occur at any time of year. (cdc.gov)
- For example, there's a study from Michigan that spanned eight seasons indicating that only 2.5% of infections with common human coronaviruses being identified between June and September. (cdc.gov)
- CoV infections can cause everything from a common cold to severe respiratory syndromes, such as severe acute respiratory syndrome (SARS-CoV) and Middle Eastern respiratory syndrome (MERS-CoV).COVID-19 (SARS-CoV2) is a new variant of the coronavirus, and its isolation occurred in China on January 7th, 2020. (bvsalud.org)
- Coronavirus is a family of viruses that cause respiratory infections, being SARS-CoV2 the seventh coronavirus in this family. (bvsalud.org)
Disease20
- The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. (eurosurveillance.org)
- A new coronavirus associated with human respiratory disease in China. (eurosurveillance.org)
- In several Italian centers, where the incidence of Covid-19 was higher - Professor Ravelli told ANSA - more frequent cases of Kawasaki disease have occurred than we have observed before the arrival of the coronavirus. (keepkidshealthy.com)
- And next came an alert from the CDC on what they are calling multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). (keepkidshealthy.com)
- Here, we report the clinical validation of the specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay using the enzyme Cas13a from Leptotrichia wadei for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-the virus that causes coronavirus disease 2019 (COVID-19)-in 154 nasopharyngeal and throat swab samples collected at Siriraj Hospital, Thailand. (nature.com)
- The virus causing coronavirus disease 2019 (COVID-19), is not the same as the coronaviruses that commonly circulate among humans and cause mild illness, like the common cold. (yakimacounty.us)
- They studied the potential ability to cause heart disease of both SARS-CoV-2 spike protein and the NL63 spike protein. (sciencedaily.com)
- Prior to the past two decades, the four circulating species of coronaviruses associated with human disease were known to be a significant cause of the common cold and other mild URIs. (thieme-connect.com)
- They also investigated the impact of pre-existing immune levels against seasonal CoV S on the immune protection conferred by messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccinations. (news-medical.net)
- In a recent study posted to the medRxiv * preprint server, a team of researchers used a high throughput systems serology method to compare serum and cerebrospinal fluid (CSF) samples from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals with and without long coronavirus disease (COVID) symptoms to determine changes in the SARS-CoV-2 humoral immune responses. (news-medical.net)
- Reported illnesses have ranged from mild symptoms to severe illness and death for confirmed coronavirus disease 2019 (COVID-19) cases. (southmetro.org)
- Why is the disease being called coronavirus disease 2019, COVID-19? (cdc.gov)
- The new name of this disease is coronavirus disease 2019, abbreviated as COVID-19. (cdc.gov)
- Only 7 coronaviruses are known to cause disease in humans. (msdmanuals.com)
- 9-11 Unlike other countries, Japan the illness later termed coronavirus disease (COVID-19). (who.int)
- Melisa Shah] SARS-CoV-2, the virus that causes coronavirus disease 2019 or COVID-19, has placed a lot more attention on the common human coronaviruses. (cdc.gov)
- All four common human coronaviruses, like you say, generally cause less severe disease than the types of coronaviruses that cause MERS, SARS, and COVID-19. (cdc.gov)
- More severe disease is generally seen in infants and older adults, and one of the alpha coronaviruses (NL63) has been associated with croup in children. (cdc.gov)
- All human beings are susceptible to host this virus, however, those with comorbidities, chronic diseases and older than 60 years are more easily affected by the severity of the disease COVID-19. (bvsalud.org)
- This rate is patterns, gene sequencing, immuno- Centre for Disease Prevention and higher than that of severe acute respira- genicity and the animal-human and hu- Control (ECDC) and the National In- tory syndrome coronavirus (SARS), man-human interfaces. (who.int)
Nucleocapsid Protein1
- The N-terminal domain of the nucleocapsid protein from Middle East respiratory syndrome coronavirus (MERS-CoV NP-NTD) contains many positively charged residues and has been identified to be responsible for RNA binding during ribonucleocapsid formation by the virus. (iucr.org)
Viruses11
- Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). (uwc.ac.za)
- Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (mdpi.com)
- Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
- These include influenza viruses, rhinoviruses, and coronaviruses. (frontiersin.org)
- Coronaviruses are positive-strand, enveloped RNA viruses that are important pathogens of mammals and birds. (nhbs.com)
- This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus and mouse hepatitis virus. (nhbs.com)
- This undated file image released by the British Health Protection Agency shows an electron microscope image of a coronavirus, part of a family of viruses that cause ailments including the common cold and SARS, which was first identified in the Middle East. (blacklistednews.com)
- Coronavirus is a family of viruses that share similar characteristics. (24hrcares.com)
- All three are infectious respiratory diseases that began as animal viruses and evolved to infect humans. (24hrcares.com)
- Coronaviruses are enveloped RNA viruses that cause respiratory illnesses of varying severity from the common cold to fatal pneumonia. (msdmanuals.com)
- Coronaviruses (CoV) make up a large family of viruses, known since the mid-1960s, which received this name due to the spikes on its surface, which resemble a crown (from the Latin corona). (bvsalud.org)
Outbreak4
- Before the outbreak of severe acute respiratory syndrome caused by the SARS coronavirus in 2003, human coronaviruses (HCoVs) had not been considered harmful respiratory pathogens. (hindawi.com)
- In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. (nhbs.com)
- The outbreak of new Cov-2 epidemic was detected in December 2019 in the city of Wuhan, China, caused by Severe Acute Respiratory Syndrome Coronavirus −2 and started its rapid spread througth the world. (intechopen.com)
- Subsequent investigation by GreatGameIndia linked the agents to Chinese Biological Warfare Program from where the virus is suspected to have leaked causing the Wuhan Coronavirus outbreak. (blacklistednews.com)
MERS6
- ABSTRACT A literature review of publically available information was undertaken to summarize current understanding and gaps in knowledge about Middle East respiratory syndrome coronavirus (MERS-CoV), including its origin, transmission, effective control measures and management. (who.int)
- RÉSUMÉ Une analyse documentaire des informations publiques disponibles a été entreprise afin de passer en revue les connaissances et les lacunes actuelles sur le coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV), notamment sur son origine, la transmission, les mesures de lutte efficaces et la prise en charge. (who.int)
- Middle East respiratory syndrome (MERS) is a severe, acute respiratory illness caused by the MERS coronavirus (MERS-CoV). (msdmanuals.com)
- There are other types of human coronaviruses, including the Middle East respiratory syndrome (or MERS) and the severe acute respiratory syndrome (or SARS), and of course COVID-19. (cdc.gov)
- Orient (MERS-CoV), notamment sur son origine, la transmission, les mesures de lutte efficaces et la prise en charge. (who.int)
- Consequently, stitute for Clinical Excellence (NICE) estimated at 15%, and is strongly age- a myriad of literature has been pro- databases on 19 April 2015 for "Middle and sex-dependent ( 3 ).To date, 26 duced, much of it providing evidence East respiratory syndrome coronavirus" countries on four continents ( 2,4 ) have to answer questions about the origin, [MESH] OR "MERS-CoV" [keyword] been affected. (who.int)
Infects1
- smallpox, for example, is a virus that only infects humans. (24hrcares.com)
HCoVs1
- One potential determinant of differential immune responses to SARS-CoV-2 across the life course may be the timing of exposure to the four additional endemic human coronaviruses (hCoVs). (nature.com)
Another coronavirus1
- It isolated and provided the first genome sequence of the SARS coronavirus and identified another coronavirus NL63 in 2004. (blacklistednews.com)
Pathogens1
- The Section of Genomic Epidemiology and Evolution of Pathogens (GEEP) at DIEPS, FIC, NIH aims to answer critical questions about pathogen emergence and establishment in animal and human populations using evolutionary and epidemiological information extracted from viral genomes. (nih.gov)
Known to infect2
- Fouchier used a broad-spectrum "pan-coronavirus" real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses known to infect humans. (blacklistednews.com)
- Currently, seven coronaviruses are known to infect people and the remaining identified coronaviruses are only seen in animals. (24hrcares.com)
Endemic1
- They are sometimes referred to as the common cold or endemic or seasonal coronaviruses. (cdc.gov)
Common coronavirus2
- For more information on these common coronavirus types, visit the Human Coronavirus Types webpage. (cdc.gov)
- Patients with COVID-19 will be evaluated and cared for differently than patients with common coronavirus diagnosis. (yakimacounty.us)
Mild2
- There are many types of human coronaviruses including some that commonly cause mild upper-respiratory tract il nesses. (cdc.gov)
- In general, coronaviruses are named for their crown-like spikes on their surface, and the common human coronaviruses cause mild to moderate upper respiratory tract illness (like the common cold). (cdc.gov)
Protein9
- Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. (nature.com)
- The crystal structure of the human RIG-I helicase domain, a key player protein in the antiviral innate immune response, is reported. (iucr.org)
- In a study evaluating mice and human heart cells, the SARS-CoV-2 spike protein inflamed the heart muscle cells, which can lead to heart injury. (sciencedaily.com)
- Now, researchers have found that the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to heart muscle injury through the inflammatory process, according to preliminary research to be presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2022. (sciencedaily.com)
- Their results showed that the SARS-CoV-2 spike protein activated the natural immune response in heart muscle cells and damaged the heart, but the NL63 spike protein did not. (sciencedaily.com)
- The fact that the SARS-CoV-2 spike protein is activating the natural immune response may explain the high virulence compared to the other coronaviruses," Lin said. (sciencedaily.com)
- To investigate the impact of the SARS-CoV-2 spike protein on the heart, researchers cloned the SARS-CoV-2 spike protein and the NL63 spike protein into the AAV9 viral vector. (sciencedaily.com)
- They found that the AAV9-mediated the SARS-CoV-2 spike protein, and not the NL63 spike protein, caused heart dysfunction, hypertrophic remodeling (enlargement) and cardiac inflammation. (sciencedaily.com)
- The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. (joplink.net)
Wuhan2
- In December 2019, SARS CoV-2-COVID-19-was first identified in humans in Wuhan, China. (24hrcares.com)
- In December 2019, severe acute respiratory syndrome confined spaces - and the change in attitudes of patients coronavirus 2 (SARS-CoV-2) was first identified in a towards receiving medical care and the responses of cluster of pneumonia cases in Wuhan, China, 1 with medical institutions. (who.int)
Bocavirus1
- dyspnea (63% vs 11%) and wheezing (75% vs 22%) were more common in children with human bocavirus. (bvsalud.org)
Species1
- Elabscience Target Species: Human Type: Competitive Assay Time: 1.5h Detection Type: Colormetric Sensitivity: N/A Detection Range: N/A. (proteomecommons.org)
Rhinoviruses1
- Human rhinoviruses (HRVs) are a highly prevalent cause of acute respiratory infection in children. (plos.org)
ACE24
- This Human ACE2 coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. (proteomecommons.org)
- Immature angiotensin converting enzyme (ACE2) interferes with coronavirus entry into the cells. (thieme-connect.com)
- Synthesized peptide derived from the Internal region of human ACE2. (avivasysbio.com)
- Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus. (avivasysbio.com)
Diseases3
- Acute respiratory illnesses (ARIs) are the most common respiratory infectious diseases among humans globally. (frontiersin.org)
- The NML is Canada's only level-4 facility and one of only a few in North America equipped to handle the world's deadliest diseases, including Ebola, SARS, Coronavirus, etc. (blacklistednews.com)
- for naming of new human infectious diseases. (cdc.gov)
Pneumonia2
- Pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is spreading globally. (medsci.org)
- Pneumonia caused by the SARS-CoV-2 is spreading continuously, the ability to adapt host and genomic mutation of Coronavirus (CoV) lead to hampering in treatment or control of the infection. (medsci.org)
Spike1
- Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. (nature.com)
Dendritic cells1
- Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells. (eurosurveillance.org)
Sequences1
- The genomic sequences from nine patients who were among the first cases of this serious infection (COVID-19) are almost genetically identical, which suggests the very recent appearance of this Coronavirus in humans 3 . (bvsalud.org)
Genome2
- Coronaviruses: Molecular and Cellular Biology is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. (nhbs.com)
- Chinese researchers isolated the virus and three days later shared data from the viral genome internationally, calling it a new Coronavirus 2 . (bvsalud.org)
Severe acute re2
- The important discovery in 2003 that the causative agent of severe acute respiratory syndrome (SARS) was a new, potentially lethal coronavirus named SARS-CoV provided major impetus to coronavirus research. (nhbs.com)
- It is caused by Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2) and started its rapid spread through the world [ 1 ]. (intechopen.com)
Antibody1
- Antibody responses against four other coronaviruses and three non-coronavirus control antigens were also measured. (news-medical.net)
Occur1
- The transmission of the coronavirus occurs between humans, and it can occur from person to person through the air, through coughing or sneezing, by touching or shaking hands or by contact with contaminated objects or surfaces, followed by contact with the mouth, nose or eyes. (bvsalud.org)
CoVs1
- Seasonal CoVs have widely circulated among humans for several years. (news-medical.net)