Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.SARS Virus: A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Severe Acute Respiratory Syndrome: A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.Coronavirus 229E, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.Coronavirus OC43, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.Coronavirus, Bovine: A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.Murine hepatitis virus: A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).Coronavirus, Feline: A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.Spike Glycoprotein, Coronavirus: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.Coronaviridae: Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.Coronavirus, Rat: A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.Coronavirus, Canine: A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.Transmissible gastroenteritis virus: A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.Feline Infectious Peritonitis: Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Infectious bronchitis virus: A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.Coronavirus NL63, Human: A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Nucleocapsid Proteins: Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Peptidyl-Dipeptidase A: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Coronavirus, Turkey: A species of CORONAVIRUS causing enteritis in turkeys and pullets.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Porcine Respiratory Coronavirus: A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Gastroenteritis, Transmissible, of Swine: A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Viral Proteins: Proteins found in any species of virus.Viverridae: The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.RNA Replicase: An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Enteritis, Transmissible, of Turkeys: An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.Viral Nonstructural Proteins: Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.Antigens, CD13: Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.Nucleocapsid: A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.

Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice. (1/657)

Mutations in an immunodominant CD8 CTL epitope (S-510-518) are selected in mice persistently infected with the neurotropic JHM strain of mouse hepatitis virus. These mutations abrogate recognition by T cells harvested from the infected CNS in direct ex vivo cytotoxicity assays. Previous reports have suggested that, in general, an oligoclonal, monospecific T cell response contributes to the selection of CTL escape mutants. Herein, we show that, in MHV-JHM-infected mice, the CD8 T cell response after intraperitoneal infection is polyclonal and diverse. This diverse response was shown to include both polyclonal and oligoclonal components. The polyclonal data were shown to fit a logarithmic distribution. With regard to specificity, we used a panel of peptide analogues of epitope S-510-518 and spleen-derived CD8 T cell lines to determine why only a subset of possible mutations was selected in persistently infected mice. At a given position in the epitope, the mutations identified in in vivo isolates were among those that resulted in the greatest loss of recognition. However, not all such mutations were selected, suggesting that additional factors must contribute to selection in vivo. By extrapolation of these results to the persistently infected CNS, they suggest that the selection of CTL escape mutants requires the presence of a monospecific T cell response but also show that this response need not be oligoclonal.  (+info)

Application of nested polymerase chain reaction to detection of mouse hepatitis virus in fecal specimens during a natural outbreak in an immunodeficient mouse colony. (2/657)

The usefulness of RT-PCR for the detection of MHV in tissues and feces of experimentally infected animals has been reported, but it was unclear whether the method was also applicable for the detection of MHV during a natural outbreak. Enterotropic infection is considered to be the most common form of natural infection among various forms of MHV infection. In this paper, RT-nested PCR was performed to detect MHV excreted in the feces during an outbreak in an immunocompromised A/WySnJ mouse colony. The expected bands were amplified after nested PCR from 20 fecal samples out of 37. These results showed that RT-nested PCR could be applicable for the diagnosis for MHV natural infection.  (+info)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (3/657)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability.  (+info)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (4/657)

Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA.  (+info)

Selection of CD8+ T cells with highly focused specificity during viral persistence in the central nervous system. (5/657)

The relationships between T cell populations during primary viral infection and persistence are poorly understood. Mice infected with the neurotropic JHMV strain of mouse hepatitis virus mount potent regional CTL responses that effectively reduce infectious virus; nevertheless, viral RNA persists in the central nervous system (CNS). To evaluate whether persistence influences Ag-specific CD8+ T cells, functional TCR diversity was studied in spleen and CNS-derived CTL populations based on differential recognition of variant peptides for the dominant nucleocapsid epitope. Increased specificity of peripheral CTL from persistently infected mice for the index epitope compared with immunized mice suggested T cell selection during persistence. This was confirmed with CD8+ T cell clones derived from the CNS of either acutely (CTLac) or persistently (CTLper) infected mice. Whereas CTLac clones recognized a broad diversity of amino acid substitutions, CTLper clones exhibited exquisite specificity for the wild-type sequence. Highly focused specificity was CD8 independent but correlated with longer complementarity-determining regions 3 characteristic of CTLper clonotypes despite limited TCR alpha/beta-chain heterogeneity. Direct ex vivo analysis of CNS-derived mononuclear cells by IFN-gamma enzyme-linked immunospot assay confirmed the selection of T cells with narrow Ag specificity during persistence at the population level. These data suggest that broadly reactive CTL during primary infection are capable of controlling potentially emerging mutations. By contrast, the predominance of CD8+ T cells with dramatically focused specificity during persistence at the site of infection and in the periphery supports selective pressure driven by persisting Ag.  (+info)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (6/657)

This is the first report of the production of monoclonal antibodies against elk coronavirus. The nucleoprotein gene of elk coronavirus was amplified by PCR and was cloned and expressed in a prokaryotic expression vector. Recombinant nucleocapsid protein was used to immunize mice for the production of hybridomas. Twelve hybridomas that produced monoclonal antibodies against the nucleocapsid protein of elk coronavirus were selected by an indirect fluorescent-antibody test, an enzyme-linked immunosorbent assay, and a Western blot assay. Ten of the monoclonal antibodies were of the immunoglobulin G1 (IgG1) isotype, one was IgG2a, and one was IgM. All had kappa light chains. By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues. Antinucleoprotein monoclonal antibodies were found to be better at ruminant coronavirus detection than the anti-spike protein monoclonal antibodies. Because nucleoprotein is a more abundant antigen than spike protein in infected cells, this was not an unexpected finding.  (+info)

Interference of natural mouse hepatitis virus infection with cytokine production and susceptibility to Trypanosoma cruzi. (7/657)

Mouse hepatitis virus (MHV) infection can have a pronounced impact on several investigation areas. Reports on natural MHV outbreaks are rare and most studies have been conducted by deliberately infecting mice with MHV laboratory strains that cause moderate to severe disturbances to the immune system. We have investigated the effects of a natural acute outbreak of MHV in our otherwise specific-pathogen-free (SPF) inbred mouse colonies, and of enzootic chronic MHV infection on cytokine production and resistance to the intracellular pathogen Trypanosoma cruzi. We found that BALB/c and/or C57BL/6 SPF mice that had been injected with T. cruzi blood trypomastigotes from recently MHV-contaminated (MHV+) mice developed significantly higher parasite blood counts, accelerated death, and showed higher IL-10 production by spleen cells than their counterparts whose T. cruzi inoculum was derived from MHV-negative (MHV-) donors. Interferon-gamma (IFN-gamma) production by MHV+ and MHV- mice was not significantly different. In contrast, T. cruzi infection of chronically MHV-infected mice did not result in major changes in the course of infection when compared with that observed in mice from MHV- colonies, although a trend to higher parasitaemia levels was observed in BALB/c MHV+ mice. Nevertheless, both BALB/c and C57BL/6 T. cruzi-infected MHV+ mice had diminished IFN-gamma production to parasite-antigen stimulation in comparison with similarly infected MHV- mice. Interleukin-10 (IL-10) production levels by spleen cells did not differ between chronic MHV+ and MHV- mice, but IFN-gamma neutralization by monoclonal antibody treatment of anti-CD3-stimulated spleen cell cultures showed higher levels of IL-10 synthesis in MHV+ BALB/c mice.  (+info)

Antibody prevents virus reactivation within the central nervous system. (8/657)

The neurotropic JHM strain of mouse hepatitis virus (JHMV) produces an acute CNS infection characterized by encephalomyelitis and demyelination. The immune response cannot completely eliminate virus, resulting in persistence associated with chronic ongoing CNS demyelination. The contribution of humoral immunity to viral clearance and persistent infection was investigated in mice homozygous for disruption of the Ig mu gene (IgM-/-). Acute disease developed with equal kinetics and severity in IgM-/- and syngeneic C57BL/6 (wt) mice. However, clinical disease progressed in IgM-/- mice, while wt mice recovered. Viral clearance during acute infection was similar in both groups, supporting a primary role of cell-mediated immunity in viral clearance. In contrast to wt mice, in which infectious virus was reduced to below detection following acute infection, increasing infectious virus was recovered from the CNS of the IgM-/- mice following initial clearance. No evidence was obtained for selection of variant viruses nor was there an apparent loss of cell-mediated immunity in the absence of Ab. Passive transfer of anti-JHMV Ab following initial clearance prevented reactivation of infectious virus within the CNS of IgM-/- mice. These data demonstrate the clearance of infectious virus during acute disease by cell-mediated immunity. However, immunologic control is not maintained in the absence of anti-viral Ab, resulting in recrudescence of infectious virus. These data suggest that humoral immunity plays no role in controlling virus during acute infection, but plays an important role in establishing and maintaining CNS viral persistence.  (+info)

BANGKOK, Feb 29 (Reuters) - Thailand recorded a new coronavirus infection, taking its tally to 42 cases since January, a health official said on Saturday.. The victim is a 21-year-old Thai salesman whose job brought him exposure to foreign tourists, the permanent secretary of the health ministry, Sukhum Kanchanaphimai, told a news conference.. Thailand has not yet had a death from the virus, although 28 patients have recovered and 14 are being treated in hospital.. The rapid spread of the coronavirus has fuelled fears of a pandemic, with six countries reporting their first cases this week as the World Health Organization raised its global risk alert to "very high". (Reporting by Panu Wongcha-um; Editing by Clarence Fernandez) ...
The data presented in this thesis is incorporated into the model of early events of coronavirus infection and focuses on the innate responses by glia and their potential interactions with the mounting adaptive immune response. By utilizing transgenic mice to purify distinct populations of glia at different times during coronavirus infection of the central nervous system, the unique cell-specific responses can be evaluated in vivo to provide a fuller picture of the events leading to persistent viral infection. These new findings emphasize the protective role of microglia in providing early IFNalphabeta expression and the indirect modulation of this response by T cell activity. Microglia express a broad repertoire of pathogen associated pattern receptors (i.e. TLRs and RIG-I family helicases) and thereby trigger IFNalphabeta expression in direct response to viral infection. IFNalphabeta expression declines in correlation with effective clearance of virus from microglia by T cell activity. ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Rao, P.V.; Gallagher, T.M., 1998: Intracellular complexes of viral spike and cellular receptor accumulate during dytopathic murine coronavirus infections
We are not slowing it. And it is accelerating on its own," Cuomo said. "One of the forecasters said we were looking at a freight train coming across the country. Were now looking at a bullet train.". New York already has more than 23,000 positive cases and 183 deaths as of Tuesday, March 24, according to figures from Johns Hopkins University obtained by the AP.. The rate of infection is doubling about every three days, Cuomo said. Early projections put the peak of New Yorks cases in early May. Now theyre saying it could come in two to three weeks (mid-April).. The coronavirus pandemic has infected more than 395,000 people and killed over 17,000 worldwide. The illness causes mild or moderate symptoms in most people, but severe symptoms are more likely in the elderly or those with existing health problems. More than 103,000 people have recovered so far, mostly in China.. Michigan Gov. Gretchen Whitmer issued a statewide "shelter-in-place order on Monday, March 23, that went into effect today, ...
I wrote here the other day on the recent recommendation that people taking either ACE (angiotensin-converting enzyme) inhibitors or ARBs (angiotensin receptor
The number of new coronavirus infections inside China - the source of the outbreak - was for the first time overtaken by fresh cases elsewhere on Wednesday, with Italy and Iran emerging as epicenters of the rapidly spreading illness.
many people will get infected or sick during this outbreak. most coronavirus infections will either have no symptoms or mild symptoms consistent with the flu.
The number of people who have died from coronavirus infection in France rose by 427 to 24,087 on Wednesday, while hospitalizations for the disease and people in ICU units continued to decline, the health ministry said in a statement.
Major nations are in a race to make an effective vaccine that could help treat the novel coronavirus infection COVID-19. As hundreds of thousands are infected across the world and over sixteen thousand killed, the pandemic shows no signs of relenting.
There are new tests and updates everyday and we hope to update everyone as soon as we can with the most recent news on Coronavirus Covid-19 infection.. Vaccines? Work is progressing but we should not expect a vaccine for quite some time.. Testing? Yes, lots of updates this week. There are essentially 3 types of tests available. Lets analyse them together.. PCR Swab Testing. This is the test that is carried out by the government that involves a swab into the back of the throat/nose to get a sample of the viral shedding. This test takes 2-3 days to get a result. It tells you if you are ACTIVELY having a Coronavirus infection. It doesnt tell you if you have HAD IT IN THE PAST. For the test to work, it is very important to carry out the swab test correctly. Therefore, it is possible to get false negatives, meaning that you actively do have the virus but you werent able to get a good swab of the viral shredding, hence tested negative. At the clinic, we do not send the swabs out for this reason, ...
COVID-19 Risk & Immunity Report is a DNA-Based assessment of your immune response and susceptibility to coronavirus infection. For more information call at 1800-102-4595
The number of people in intensive care units (ICU) for coronavirus infection in France fell slightly for the first time since the start of the epidemic, but the number of people dying in nursing homes jumped by more than 50 percent over two days, health m... ...
Florida-based grocery chain Publix, which has stores in the Carolinas, announced it will install plexiglass barriers to protect its cashiers, joining other retailers that are installing the shields to protect employees and customers from a coronavirus infection.
As coronavirus infections rise across the United States, public health experts widely agree its time for a drastic step: Every state in the nation should now issue the kind of stay-at-home orders first adopted by the hardest-hit places. And while most states will probably not need to keep the rules in place for months upon months, many health specialists say the lockdowns will need to be kept up for several weeks. Yet among these same experts, there is debate when it comes to the natural next question: What strategy can be deployed after the lockdowns are lifted?. ...
Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...
Porcine epidemic diarrhea virus: current insights Chaochao Lv,1,* Yan Xiao,1,* Xiangdong Li,1 Kegong Tian,1,2 1National Research Center for Veterinary Medicine, Luoyang, People's Republic of China; 2College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, People's Republic of China *These authors contributed equally to this review Abstract: Porcine epidemic diarrhea virus (PEDV), an enveloped, single-stranded, positive-sense RNA virus belonging to the genus Alphacoronavirus in the family Coronaviridae, can infect pigs of all ages and causes acute and watery diarrhea, vomiting, dehydration, and high mortality in neonatal piglets. This disease was first observed in England in 1971 and was subsequently reported in many swine-producing countries in Europe and Asia. In contrast to the situation in Europe, the disease has remained a major cause of diarrhea outbreaks on swine farms in Asia. Since late 2010, severe porcine epidemic diarrhea (PED) epizootics caused
Interest in porcine epidemic diarrhea has grown since the 2013 outbreak in the United States caused major losses, with mortality rates up to 100 % in suckling piglets. In Mexico, an outbreak of porcine epidemic diarrhea, characterized by 100 % mortality in piglets, began in March 2014 in the State of Mexico. The aim of this study was to confirm and identify porcine epidemic diarrhea virus (PEDV) in samples from piglets with suggestive clinical signs using virological, histological, and molecular techniques. Necropsy was performed on 13 piglets from two litters with initial and advanced clinical signs. Suggestive lesions of acute infection with PEDV were detected in histological sections of the small and large bowels; specifically, multiple virus particles with visible crown-shaped projections were observed using electron microscopy and negative staining. Viral isolation was performed in Vero cells with trypsin. Infection was monitored by observation of cytopathic effect, and titration was ...
Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…
Looking for online definition of Coronavirus infections in the Medical Dictionary? Coronavirus infections explanation free. What is Coronavirus infections? Meaning of Coronavirus infections medical term. What does Coronavirus infections mean?
Porcine epidemic diarrhea virus (PEDV) is a coronavirus that infects pigs and can have mortality rates approaching 100% in piglets, causing serious economic impact. The 3C-like protease (3CL pro) is essential for the coronaviral life cycle and is an appealing target for the development of therapeutics. We report the expression, purification, crystallization and 2.10 angstrom X-ray structure of 3CL pro from PEDV. Analysis of the PEDV 3CL pro structure and comparison to other coronaviral 3CL pros from the same alpha-coronavirus phylogeny shows that the overall structures and active site architectures across 3CL pros are conserved, with the exception of a loop that comprises the protease S-2 pocket. We found a known inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL pro, (R)-16, to have inhibitor activity against PEDV 3CL pro, despite that SARS-3CL pro and PEDV 3CL pro share only 45.4% sequence identity. Structural comparison reveals that the majority of residues involved ...
Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...
In late 2013, outbreaks of porcine epidemic diarrhea virus (PEDV) infection recurred in South Korea. Genetic and phylogenetic analyses showed that isolates from the outbreaks were most closely related to emergent US strains of PEDV. These US strain-like PEDV variants are prevalent in South Korea and responsible for recent outbreaks in the country.
The USDA has reported another 296 cases of porcine epidemic diarrhea virus (PEDv) last week. That brings the number of cases in the last 10 months to 4,757. The disease was first reported in the U.S. hog population in May 2013, with animals in 27 states infected. Unfortunately, each case report can mean just one animal has been sickened, or an entire herd at one farm is sick. The virus, which is deadly for baby pigs, doesnt affect adult hogs. The disease has killed more than 4 million piglets in this country since May 2013. This is most likely going to cause dramatic price increases at the consumer level in the next year, since hog prices are at record highs.The USDAs estimate of hog slaughter on March 21, 2014 was 360,000, down 51,000 head from a week ago. Scientists say that the … [Read more...] ...
On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.
WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR Focal Point (NFP) of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 year-old...
WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...
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An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the
BROOKINGS - South Dakota swine producers and veterinarians have been closely monitoring the developments surrounding Porcine Epidemic Diarrhea (PED) virus infections over the past several months.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV. We also determined high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody. The structures reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they define four conformational states of the trimer wherein each receptor-binding domain is either ...
The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its "family tree".. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...
Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...
Summary_MERS-CoV_15Apr15_final.pdf (573.1 KB) Recent evolution patterns of the Middle East respiratory syndrome coronavirus (MERS-CoV) Mazin A. Barry MD1, Sarah S. Al Subaie MD[2], Ali M. Somily MD[3], Abdulaziz A. Bin…
LAGOS State Government, alerted its indigenes traveling to other parts of the world with confirmed cases of coronavirus infections - a severe, life-threatening respiratory disease - to take adequate precautions to protect themselves from the infection. The coronavirus known as Middle East Respiratory Syndrome Coronavirus (MERS-CoV, is currently ravaging countries in the Middle East and…
Since the Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in Saudi Arabia in 2012, there have been more than 2,400 confirmed cases of the infection, resulting in greater than 800 deaths - an alarming fatality rate of 35 percent. For this reason, researchers have been eager to identify any risk factors that contribute to the development of severe or lethal disease. Current clinical evidence points to diabetes as a major risk factor in addition to other comorbidities including kidney disease, heart disease, and lung disease.. Researchers from the University of Maryland School of Medicine (UMSOM) and the Johns Hopkins University School of Medicine have demonstrated in a new study, published earlier this week in the Journal of Clinical Investigation Insights, how diabetes contributes to mortality from MERS-CoV infections, and the finding could shed light on why other respiratory illnesses like the flu or pneumonia might strike those with diabetes more severely.. They ...
Porcine Epidemic Diarrhea" sounds incredibly unpleasant. The disease first showed up in the United States last year, and thanks to the cold weather nationwide has showed up in 27 states. What is it, and should humans be worried? Not unless you own any hogs or you have a tight budget for meat for the next year or two.. The disease, PEDv for short, is a virus that sounds a lot like the "stomach bugs" that we humans get. The trouble is that its incredibly dangerous for piglets, killing up to 80-100% of babies that are infected. Its less deadly for adult pigs, but still pretty deadly. In the last year, PEDv has killed four to five million pigs in less than a year. "While it has absolutely no impact on food safety, it has clear implications for the pork industry in terms of supplying pork to consumers," the president of the National Pork Board said in a statement. Experts say that theres no food safety danger-PEDv cant infect humans, Its not at all related to "swine flu," which did infect humans ...
WHO immediately alerted all its Member States about the novel coronavirus and has been leading the coordination of and providing guidance to health authorities and technical health agencies. A joint Republic of Korea-WHO high-level mission was undertaken in June 2015 with the aim of gaining information and reviewing the situation. The team has also assessed the public health response efforts and provided its recommendations.. The IHR Emergency Committee convened by the WHO Director-General held its ninth meeting regarding MERS-CoV on 16 June 2015. The Committee concluded that the conditions for a public health emergency of international concern have not been met. WHO/Europe will continue to provide input to all aspects of this response, including participating in risk assessment, providing support to Member States that have had cases, supporting surveillance and laboratory capacities and disseminating information.. WHO/Europe in collaboration with the European Centre for Disease Prevention and ...
During the course of this project, we witnessed the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). MERS-CoV is associated with severe respiratory disease and has an exceptionally high case fatality of approximately 40%. Initially, it was not known either how efficiently the MERS-CoV could replicate on the human airway epithelium or whether any measures were available to inhibit MERS-CoV replication in the human airway epithelium, indeed, even the nature of the target cell(s) was unknown. Since primary HAE-cultures were immediately at our command, we could participate in a number of international studies. We were the first to demonstrate that MERS-CoV can efficiently replicate on the primary human epithelium, which highlights its zoonotic potential (2).. Importantly, the treatment of MERS-CoV-infected HAE-cultures with interferon-alpha and interferon-lambda significantly reduced viral replication. Hence, this strategy opens up a therapeutic option for MERS-CoV patients ...
Via InterAksyon.com, a PNA report: PH remains MERS-CoV free, but health check continues - DOH. Excerpt: Over a month after a returning overseas Filipino worker (OFW) initially tested positive for Middle East Respiratory Syndrome coronavirus (MERS-CoV), the Department of Health...
Merck Animal Health and Harrisvaccines, Inc. announced the companies have entered into an agreement under which Merck Animal Health will acquire Harrisvaccines, a privately-held company …. ...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Results: In this study we constructed a recombinant baculovirus that was potent to express PEDV-S1 protein; PEDV-S1 protein (S1) which is essential to generate immunogenic VLPs in insect cells. A triplet cassette providing simultaneous and independent expression of S1 gene of PED virus was designed and subjected to synthesis. The cassette was then cloned into pFastBacHTb plasmid and then transformed in to competent Escherichia coli DH10Bac cells and the recombinant bacmids were produced following the homologous Tn7 site-specific transposition. This construction was verified by polymerase chain reaction (PCR) and then transfected into Sf9 insect cells to package new recombinant baculovirus expressing complex proteins of the interest. Restriction map of pFastBacHTb_PEDV-S1 plasmid confirmed the fidelity of the clone. The PCR carried out on the recombinant bacmids as template indicated that a proper homologous recombination has occurred between pFastBacHTb_PEDV-S1 donor plasmid and the bacmid. ...
We establish new minimum protein requirements for the formation of double-membrane vesicles (DMVs), a prototypic type of virus-induced membrane structure that also plays a role in the replication of other viral pathogens. We demonstrate a direct link between membrane remodelling and viral polyprotein processing and reveal the likely DMV biogenesis mechanism.. This work was done in close collaboration between the departments of Molecular Virology and Cell and Chemical Biology at the LUMC.. Oudshoorn, D., Rijs, K., Limpens, R., Groen, K., Koster, A.J., Snijder, E.J., Kikkert, M. and Barcena, M., "Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus Nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral Rna Replication" (2017) MBio, 8, 6.. ...
In a surprise finding, South Korean researchers observed point mutations in MERS-CoV isolates that rendered the virus less virulent as the outbreak in that country spread last year, a finding that may have ramifications for vaccine development, according to a study today in mBio.. The scientists isolated 13 viral genomes from 14 patients infected with MERS-CoV (Middle East respiratory syndrome coronavirus) in late spring through July last year in South Korea. They found that 12 of the genomes had two specific mutations (I529T and D510G) in the receptor-binding domain (RBD) of the viruss spike protein.. They also determined that the mutations impaired viral fitness and virulence, rather than making the virus more virulent, or capable of causing severe disease.. "This is an interesting strategy of coronavirus evolution to survive in nature and live together with the new host. The virus may tune down its power to attack for the sake of longer survival in the new host," said principal investigator ...
Definition of epidemic diarrhea of infant mice in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is epidemic diarrhea of infant mice? Meaning of epidemic diarrhea of infant mice as a legal term. What does epidemic diarrhea of infant mice mean in law?
WHO/Europe aim to reduce influenza-related morbidity and mortality by strengthening virological and epidemiological surveillance for mild and severe influenza; using surveillance data to estimate the burden of influenza in order to prioritize national influenza vaccination programmes; and maintaining and strengthening pandemic preparedness activities at the national level. WHO/Europe also monitors the emergence of other respiratory pathogens that have the potential to spread among humans. These include coronaviruses, which cause a range of illnesses from severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS-CoV) to the common cold.. ...
Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to estimate rates of morbidity and mortality and to examine predictors of severity among participants with 2009 H1N1 infection. In 2011, as surveillance indicated that 2009 H1N1 virus was co-circulating with other seasonal influenza A and B viruses worldwide, the protocol was expanded to include other influenza A subtypes and influenza B viruses. The current version of the protocol (released in August 2013) further broadens the scope of this observational study. With the recognition that novel respiratory viruses other than novel influenza A viruses, e.g., Middle East Respiratory Syndrome Coronavirus (MERS-CoV), could become prevalent and of major public health importance, the objectives of this protocol have been expanded ...
A new study suggests that the Middle East Respiratory Syndrome coronavirus (MERS-CoV) develops mutations that make the virus less virulent during an outbreak rather than more virulent. The study, published this week in mBio, an online open-access journal of the American Society for Microbiology, has implications for vaccine development.
A senior World Health Organization official announced that the United Nations agency would convene an emergency committee to plan for a possible escalation in illnesses caused by the Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. Dr. Keiji Fukuda, assistant director general for health...
The University of Queenslands Australian Institute for Bioengineering and Nanotechnology (AIBN) has appointed a new director following an international search.. Professor Alan Rowan will join UQ in January, taking over from AIBNs inaugural director, Professor Peter Gray.. UQ Vice-Chancellor and President Professor Peter Høj said Professor Grays leadership since 2003 had helped position AIBN as a major research institute of international standing, employing almost 500 people.. "Weve seen significant success stories, including Nanopatch vaccine technology, the manufacture of an antibody used in world-first human Hendra virus clinical trials, and collaboration between AIBN and American researchers to tackle the growing global threat of Middle East respiratory syndrome coronavirus (MERS-CoV)," Professor Høj said.. "The nanotechnology research at AIBN has had broad reaching application, from ground-breaking advancements in green energy technologies to targeted drug delivery.. Professor Rowan ...
Zymo Research Corp. announced on Monday that it released its DNA/RNA Shield, a viral inactivation solution that can help to transport viruses including Ebola and Middle East Respiratory Syndrome coronavirus (MERS-CoV).
CIDRAP News) - Jordans health ministry has sent 124 respiratory samples it collected from suspected Middle East respiratory syndrome coronavirus (MERS-CoV) cases, none of which appear to be recent infections, to the US Centers for Disease Control and Prevention (CDC) for testing, the agency said today. ...
CDC Coronavirus: Coronaviruses are common throughout the world. They can infect people and animals. Five different coronaviruses can infect people and make them sick. They usually cause mild to moderate upper-respiratory illness.
The Middle East Respiratory Syndrome Coronavirus, better known as MERS, may be an airborne virus, according to an observation paper published Tuesday in the journal mBio.. 12NewsNow Story
One of the earliest known victims of the Middle East Respiratory Syndrome coronavirus -- a retired Saudi military man who owned a herd of camels outside of ...
An Illinois man has contracted the Middle East respiratory syndrome coronavirus from the Indiana patient who was recently hospitalized, marking the first confirmed human-to-human transmission of MERS within the U.S.. 0 Comments. ...
An Illinois man has contracted the Middle East respiratory syndrome coronavirus from the Indiana patient who was recently hospitalized, marking the first confirmed human-to-human transmission of MERS within the U.S.. 0 Comments. ...
The other two cases involve a couple from Wuhan, who are a 62-year-old woman and a 63-year-old man with good past health. According to the information they provided, they took High-Speed Rail from Wuhan at 2.20pm on January 22 and arrived at the Hong Kong West Kowloon Station of the Guangzhou-Shenzhen-Hong Kong Express Rail Link at around 8pm that evening. The woman developed fever on January 23 while her husband developed cough on the same day and then fever on January 24. The couple attended the Prince of Wales Hospitals A&E Department on January 23 and were admitted for isolation. They are in stable condition. The respiratory samples of both patients were tested positive for novel coronavirus ...
The Ministry of Social Affairs and Health in France has informed WHO of an additional laboratory-confirmed case with infection of the novel coronavirus (nCoV).
If you would say YES to any of the above, do NOT report to NDBC. If you have traveled out of country in the past 30 days and/or been in contact with an individual with a positive laboratory COVID-19 test, you cannot be seen in person for 14 days. However, you may still be appropriate for our Telehealth program, please call Teresa at 952-800-8951.. _________________________________________________________________________. What is COVID-19..?. On February 11, 2020 the World Health Organization announced an official name for the disease that is causing the 2019 novel coronavirus outbreak, first identified in Wuhan China. The new name of this disease is coronavirus disease 2019, abbreviated as COVID-19. In COVID-19, CO stands for corona, VI for virus, and D for disease. Formerly, this disease was referred to as "2019 novel coronavirus" or "2019-nCoV".. A novel coronavirus is a new coronavirus that has not been previously identified. The virus causing coronavirus disease 2019 (COVID-19), is ...
People suffering from vitamin D deficiency have a higher risk of contracting a fatal coronavirus infection, a new study has revealed. A research team from Northwestern University conducted a statistical analysis of data gathered from hospitals and clinics across different countries such as China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the United Kingdom […]
TY - JOUR. T1 - Persistent infection with mouse hepatitis virus, JHM strain in DBT cell culture.. AU - Hirano, N.. AU - Goto, N.. AU - Makino, Shinji. AU - Fujiwara, K.. PY - 1981. Y1 - 1981. N2 - After inoculation with JHM strain into DBT cell monolayers, a persistently infected DBT cell culture was established without producing typical cytopathic changes after about 15th passages. By immunofluorescence virus specific antigen was demonstrated in 10 to 15% DBT cells. This persistently infected culture (JHM-CC) was resistant to superinfection with parental JHM, but such resistance was not shown against vesicular stomatitis virus. JHM-CC virus produced small plaques on DBT cell monolayers. Temperature sensitive (TS) mutant, defective interfering (DI) particle or interferon was not detected in the JHM-CC. To intracerebral inoculation with JHM-CC virus, cortisone treated ICR mice survived without showing clinical signs, however, demyelinating lesions were produced in the brain and spinal cord of ...
In the spring of 2013, a virus that had not been seen before in the United States began spreading across the major swine producing states, causing outbreaks of diarrhea in sows and the death of many baby pigs.Researchers scrambled to identify the virus as Porcine Epidemic Diarrhea Virus (PEDV), a virus that had been seen only in Asian and Europe. The virus spread quickly over the next two years, resulting in the death of over 8 million pigs. Related viruses, including swine delta corona virus (SDCV) and variants of PEDV, were also discovered during the outbreak and together are referred to as
|strong|Mouse anti Bovine Coronavirus Surface Antigen antibody, clone 5A4|/strong| recognizes the surface antigen of bovine coronavirus. Bovine coronavirus (BCoV) causes severe diarrhoea in newborn ca…
The recently emerged highly virulent variants of porcine epidemic and diarrhea virus (PEDV) remain a huge threat to the worldwide swine industry. Here, we describe the development of a bacterial artificial chromosome (BAC) reverse genetics system for PEDV based on two recent Chinese field isolates, namely CHM2013 and BJ2011C. Phylogenetically, CHM2013 is closely related to the vaccine strain SM98 whereas the isolate BJ2011C belongs to the GIIb group, a cluster that contains many recent pandemic strains. The full-length cDNA clones of the two isolates were constructed into BAC under the control of CMV promoter. The rescued viruses rBJ2011C and rCHM2013 were found to replicate at the kinetics similar to their respective parental viruses in cell culture. When tested in the 2-day-old pig model, rBJ2011C caused severe diarrhea of piglets with extensive damages to the intestinal epithelium, leading to 100% fatality within 48 hours. In contrast, the rCHM2013-inoculated piglets all survived with only very minor
The fatal case was reported from Al-Qaseem region in the Central part of the country and is not related to the cluster of cases reported from Al-Ahsa region in the Eastern part of the country. The patient was a 63-year-old man with an underlying medical condition who was admitted to a hospital with acute respiratory distress on 15 May 2013 and died on 20 May 2013. Investigation into contacts of this case is ongoing ...
10 February). As of 9 February, in mainland China, 40,171 confirmed cases had been reported, among which 3,281 were cured and discharged from hospital, 908 died, and 35,982 still under treatment. There was 23,589 suspected cases pending test results in mainland China as of 9 February. Official statistics show that between 4 and 9 February, the number of newly reported confirmed cases outside Hubei province kept declining for six consecutive days. By 9 February, no confirmed or suspected case of novel coronavirus infection had been reported among Tanzanian citizens in China and no such case reported in Tanzania either.. By 5 February, leaders of 61 countries, including Tanzanian President Dr. John Pombe Magufuli, and heads of eight international organizations wrote letters to President Xi Jinping, Premier Li Keqiang and other members of the Chinese leadership to express solidarity and support. They spoke openly in support of China and commended Chinas epidemic control efforts. An advance team of ...
Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). Methods: 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. Results: The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years).They were divided to 26 common type and 4 severe cases, all of whom had close(within 1m) contact with patients infected of novel coronavirus pneumonia. The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 ...
The recent detection of two cases of infection with a novel coronavirus provides new opportunities to improve global response strategies to zoonotic viral infections, using lessons from past outbreaks, say Larry J. Anderson, MD, and Ralph S. Baric in an editorial in the October 18 issue of the New England Journal of Medicine.
The hunt is now on to find the source of the novel coronavirus which has claimed 11 lives so far - the latest victim being a 73-year-old Emirati man.
Russia reported 9,200 new confirmed cases of the novel coronavirus on Saturday, down from 10,598 new cases reported the previous day.
US - Zoetis has awarded research grants to Suidae Health and Production and to Iowa State University to discover solutions that can help improve control of Porcine Epidemic Diarrhea virus (PEDv) in breeding and farrowing herds.
The World Pork Expo wrapped up June 7th with many presentations made about animal health, global trade, economics, and weather. These are many of the staples of animal agriculture and now they are available to others that could not attend the Expo.. The core set of many presentations are on SwineCast.com [2013 World Pork Expo] with some additional material from the National Pork Boards Pork Academy also available.. One of the main issues presented and discussed was the discovery of Porcine Epidemic Diarrhea Virus (PEDV). Several sessions looked at the issues [audio: PEDV panel discussion] and detailed the path to discover, containment, control, and research the disease [video: PEDV: What is it and how will it affect me?].. Below are additional video presentations to cover those core farm staples: What the Weather Will Hold; If I have a better feed efficiency do I make more money?; and What is the Grains and Livestock Economic Outlook??.. ...
While much work remains, 1 year after porcine epidemic diarrhea virus (PEDV) came to the United States, the National Pork Board has many research projects underway and has built an arsenal of information from the nearly $2 million in Pork Checkoff funds designated to fight the costly disease. Additionally, the Pork Checkoff continues collaboration with a number of industry players, including the National Pork Producers Council, the American Association of Swine Veterinarians, the American Feed Industry Association, the National Grain and Feed Association, the National Renderers Association, and the North American Spray Dried Blood and Plasma Protein Producers. Private companies such as Cargill also have contributed funds to aid Checkoffs PEDV research efforts.. For more information, go to www.pork.org/pedv or contact Paul Sundberg at [email protected] or 515-223-2764.. Pork Checkoff updates Youth PQA Plus program. Consumers want to know how their food is produced. Through its Youth Pork ...
While porcine epidemic diarrhea virus has caused both physical and emotional damage, the silver lining is that its bringing increased attention to biosecurity importance.
Pig farmers in the U.S. are working to protect their pigs from the deadly Porcine Epidemic Diarrhea virus (PEDv). This comes as the EU toughens rules on pig imports. Reuters Jillian Kitchener reports. - Kelly OShea, Philadelphia NDN
Smithfield Foods Inc, the worlds largest pork processor, suspended hog slaughter at its Tar Heel, North Carolina, plant on Friday because of the spread of the deadly Porcine Epidemic Diarrhea virus (PEDv) which has tightened hog supplies, industry sources said.
5-day outlook: Recent pressure on the cash hog market is likely to continue next week as supplies are building and packers will be working with a shortened slaughter schedule. With nearby hogs trading at a premium to the cash market, the price pullback should extend. If futures drop through the recent lows after this weeks pause, it would signal the market is ready to move the next leg lower.. 30-day outlook: Seasonally, pork demand typically is strong through the holidays. With hog slaughter rising and average hog weights at record highs, there will be increased pressure on demand to chew through those extra supplies.. 90-day outlook: Hog numbers should climb into mid- to late December and then start to gradually ease. If the impact from porcine epidemic diarrhea virus (PEDV) proves to be meaningful, hog numbers could decline more rapidly than anticipated. Thats keeping us out of longer-term hedges at this time.. Hedgers: 100% of expected 4th-qtr. production is hedged in Dec. lean hog futures ...
Patients with novel coronavirus pneumonia have characteristic CT features in the initial stage of infection, which can be used as an essential supplement for nucleic acid examination.
We have formed an Emergency Response Task Group to monitor the situation regarding the spread of COVID-19 and its consequences. This novel coronavirus outbreak has the potential to show the value and impact of scientific collaboration.
An analysis of about 1,000 cases of clustering infections of the novel coronavirus shows that 83 percent have occurred in families, a leading epidemiologist said on Tuesday.. Hospitals, schools, shopping malls, factories and enterprises also are high-risk places for clustering infections - a definition that refers to more than two infections at a small place, said Wu Zunyou, chief epidemiologist at the Chinese Center for Disease Control and Prevention.. About 22 percent of the clustering infections were transmitted from patient zero to other patients, and 64 percent of infections are transmitted from those patients to more patients, he said, adding that there have also been rare cases of third-generation or fourth-generation transmission when the first patient has not shown clear symptoms.. The first patient usually has lived or traveled to Wuhan, and through close contact, the patients family member was infected, which then can be transmitted to more family members, he said at a daily news ...
South Korea now has over 4,000 confirmed cases of the novel coronavirus, after the government reported nearly 600 new cases on March 2.
The Centre for Health Protection (CHP) of the Department of Health said today (January 14) that the CHP has been closely monitoring a new confirmed case of infection of novel coronavirus...
The TGA has identified certain therapeutic goods being inappropriately promoted for the prevention or treatment of novel coronavirus (2019-nCoV) infections in Australia
Health information for Novel Coronavirus (COVID-19) for Waterloo Region residents. Including information about symptoms, treatment, and how to protect yourself.
The Centers for Disease Control and Prevention announced two new patients now have the 2019 Novel Coronavirus (2019-nCoV), bringing the case total in the United
Bacon prices are rising as a virus sweeps though the Unites States, killing baby pigs. The Associated Press reported that the Porcine Epidemic Diarrhea Virus, which has never been seen in the United States, has already killed millions of pigs in twenty seven states. The price of bacon has risen nearly thirteen percent over the past year. Farmers are desperately attempting to take measures to curtail the epidemic, ranging from basic hygiene to euthanasia of livestock.. The first case of the virus was reported in May of last year. The cold winter this year did not help matters, as scientist reported the virus thrives in cold weather. Pork is at its highest price its ever. In February the average price of sliced bacon was $5.46, compared to $4.83 in 2013, and $3.62 in 2009. CEO of Tyson Foods Donnie Smith told CNBC that "you should expect to see very high prices for your ground beef, your other meat cuts, all the pork cuts will be higher this year.". The National Pork Board released a statement ...
Investigators are exploring whether something in pig feed could be a conduit for porcine epidemic diarrhea virus, which has spread to 27 states and killed millions of young pigs since it was first identified in the U.S. last April.
Investigators are exploring whether something in pig feed could be a conduit for porcine epidemic diarrhea virus, which has spread to 27 states and killed millions of young pigs since it was first identified in the U.S. last April.
In Stafford County, which has more pigs than people, Scott Pfortmiller recalls the devastating scene that swept through his familys hog operation about four years ago.For several weeks in the spring of 2014, sickness ravaged the farms farrowing barns. Piglets were dying from a very contagious porcine epidemic diarrhea virus that was affecting countless hog producers across America.The farm combatted the virus by feeding diluted fecal matter to their sows and disinfecting barns.
Here are the latest numbers of coronavirus infections and deaths, and the number of people being monitored for potential COVID-19.. The number of patients diagnosed with COVID-19 grows every day throughout the U.S. and across the world. Experts expect the number of U.S. cases to continue to rise in the coming weeks as more testing detects new infections. The numbers on this page are based on the latest statistics available. Heres the situation as it stands: Heres a daily snapshot of the number of active cases, recoveries and deaths as testing expands across the country:. Coronavirus patients reported in the US: There are a variety of sources tracking the virus, and for this story, we rely on data from Johns Hopkins University. It cross-checks reports from a number of sources, including the Centers for Disease Control and Prevention, and publishes updates several times each day.. New confirmed coronavirus patients reported in the US by day: You can keep track of the latest totals for your state ...
Due to the spread of the coronavirus in Hungary and that the epidemic is at the stage of transmissions in communities and will soon progress to the stage of mass ...
The first patient developed respiratory symptoms and fever 14 days after admission to hospital for an unrelated reason. He died 11 days later with multi-organ failure. Two of his brothers presented later to another hospital with respiratory symptoms and fever. MERS-CoV infection in the latter 2 patients was confirmed by reverse transcriptase polymerase chain reaction testing. All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine transaminase. No hospital or other social contacts are known to have acquired the infection. It appears that the index patient in this cluster acquired MERS-CoV infection whilst in hospital from an unrecognized mild or asymptomatic case.. ...
Nearly three-quarters of Coloradans are very concerned about the novel coronavirus and taking recommended precautions such as social distancing and hand-washing - even as younger people continue to be less troubled by the global outbreak.. These attitudes are illuminated in a state health department survey released Saturday, which polled nearly 45,000 Coloradans on a variety of COVID-19-related questions.. The survey - conducted between Sunday and Tuesday, before Gov. Jared Polis ordered residents statewide to stay at home - showed 72% of respondents were "very concerned" about COVID-19 in Colorado. Among 18- to 29-year-olds, however, that number dropped to 59%.. That lack of concern among some did not come from a belief that they wouldnt get sick, the survey showed. Nearly 90% of respondents said they think its somewhat or very likely that they would get sick from the novel coronavirus. ...
Between 12 and 16 October 2014, the National IHR Focal Point for the Kingdom of Saudi Arabia (KSA) notified WHO of 5 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths.
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Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a newly recognized coronavirus (MERS-Co). It was first reported in 2012 in Saudi Arabia and since then linked to countries in or near the Arabian Peninsula (United Arab Emirates, Qatar, Oman, Jordan, Kuwait, Yemen, and Lebanon) and Iran. As of May 2014, two cases had been reported in the United States, both in men who had recently returned from Saudi Arabia (1). Also Iran has been reported plenty of cases but fortunately the outbreak subsided (2).. Recently South Korea had a large outbreak of the MERS and was blamed on locating every person exposed to the disease. Many of the 180 MERS cases in South Korea, which make up the largest outbreak of the disease outside Saudi Arabia, were caught from sufferers encountered in emergency wards before they were diagnosed, during a wait for hospital places; unfortunately 30 out of 180 infected patients expired (3).. MERS is typically characterized by cough, fever, and shortness of ...
Michaela P. Trudeau, Harsha Verma, Pedro E. Urriola, Fernando Sampedro, Gerald C. Shurson, and Sagar M. Goyal The pork industry has recently experienced the devastating effects of swine corona viruses. The three known porcine corona viruses are transmissible gastroenteritis virus (TGEV), porcine delta corona virus (PDCoV), and porcine epidemic diarrhea virus (PEDV). Each of these viruses causes severe diarrhea in young pigs and increased mortality, with subsequent reductions in growth performance and increased cost to producers. These viruses are excreted through feces and can be spread by contaminated equipment, personnel, and other fomites.. After the 2013 outbreaks of PEDV in the United States, some evidence suggested that PEDV can be transmitted via contaminated feed and feed ingredients. In order to understand the role of virus-contaminated feed on its transmission, it is necessary to determine the risk of virus survival in various commonly used feed ingredients in swine diets. Our research ...
Background and summary of novel coronavirus infection - as of 21 December 2012. Over the past three months, WHO has received reports of nine cases of human infection with a novel coronavirus. Coronaviruses are a large family of viruses; different members of this family cause illness in humans and animals. In humans, these illnesses range from the common cold to infection with Severe Acute Respiratory Syndrome (SARS) coronavirus (SARS CoV).. This summary provides the latest information on all reported cases and provides details of a WHO mission to Jordan, which has concluded since the last web update.. Thus far, the laboratory confirmed cases have been reported by Qatar (two cases), Saudi Arabia (five cases) and Jordan (two cases). All patients were severely ill, and five have died.. A total of five confirmed cases have been reported from Saudi Arabia. The first two are not linked to each other and lived in different parts of the country; one of these has died. Three other confirmed cases are ...
Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis. ...
Harmon KM, Gauger PC, Zhang J, Piñeyro PE, Dunn DD, Chriswell AJ. 2015. Whole-genome sequences of novel porcine circovirus type 2 viruses detected in swine from Mexico and the United States. Genome Announc 3(6):e01315-15. doi:10.1128/genomeA.01315-15.. Thomas JT, Chen Q, Gauger PC, Giménez-Lirola LG, Sinha A, Harmon KM, et al. 2015. Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs. PLoS ONE 10(10): e0139266.. Sinha A, Gauger P, Zhang J, Yoon KJ, Harmon K. 2015. PCR-based retrospective evaluation of diagnostic samples for emergence of porcine deltacoronavirus in US swine. Vet Microbiol Sep 30: 179(3-4).. Pepin, B. J., Kittawornrat, A., Liu, F., Gauger, P. C., Harmon, K., Abate, S., Main, R., Garton, C., Hargrove, J., Rademacher, C., Ramirez, A. and Zimmerman, J. (2015), Comparison of Specimens for Detection of Porcine Reproductive and Respiratory Syndrome Virus Infection in Boar Studs. Transboundary and Emerging ...
Feline infectious peritonitis (FIP) is a highly fatal systemic disease in cats, caused by feline coronavirus (FCoV) infection. FCoV usually has little clinical significance; however, a mutation of...
"Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection" (PDF ... "Novel coronavirus infection" (Press release). WHO. 25 September 2012. Retrieved 27 September 2012.. ... Comparison of Saudi Arabia and South Korean outbreak of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection.[ ... "CDC announces second imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in the United States" ( ...
WHO: Novel coronavirus infection. 2013-02-11 [2013-02-13].. *^ James Gallagher. Coronavirus: Signs the new Sars-like virus can ... WHO confirms 13th novel coronavirus case. CIDRAP. 2013-02-21.. *^ World Health Organization. Novel coronavirus infection - ... Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection (PDF) ... WHO: Novel coronavirus infection - update (13 February 2013) (accessed 13 February 2013) ...
"Porcine innate and adaptative immune responses to influenza and coronavirus infections". Ann. N. Y. Acad. Sci. 1081: 130-36. ... To reach the site of infection, phagocytes leave the bloodstream and enter the affected tissues. Signals from the infection ... When an infection occurs, a chemical "SOS" signal is given off to attract phagocytes to the site. These chemical signals may ... During an infection, millions of neutrophils are recruited from the blood, but they die after a few days. Monocytes develop in ...
Candida albicans infection. *Candida parapsilosis infection. *Cytomegalovirus infection. *diphtheria. *human coronavirus ...
Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA virus. CBV. ... infections causing gastroenteritis are the second most common infection (after the common cold), and they result in between 200 ... "Infection and Drug Resistance. 6: 133-61. doi:10.2147/IDR.S12718. PMC 3815002 . PMID 24194646.. ... This infection is usually transmitted by contaminated water or food.[30] Toxigenic Clostridium difficile is an important cause ...
"Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization". Advances in ... Zhou P, Yang X (2020-02-03). "A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin". Nature. doi: ... Wong SK, Li W, Moore MJ, Choe H, Farzan M (Jan 2004). "A 193-amino acid fragment of the SARS coronavirus S protein efficiently ... "Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human ...
"Antiviral Effects of Antisense Morpholino Oligomers in Murine Coronavirus Infection Models". J. Virol. 81 (11): 5637-48. doi: ...
"Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization". Advances in ... Wong SK, Li W, Moore MJ, Choe H, Farzan M (Jan 2004). "A 193-amino acid fragment of the SARS coronavirus S protein efficiently ... in SARS coronavirus-induced lung injury". Nature Medicine. 11 (8): 875-9. doi:10.1038/nm1267. PMID 16007097. Human ACE2 genome ... "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus". Nature. 426 (6965): 450-4. doi:10.1038/ ...
Severe acute respiratory syndrome coronavirus as an agent of emerging and re-emerging infection. Clin Microbiol Rev. 2007 Oct; ... coronavirus HKU1 [6], bat coronavirus HKU2 to 13 [7,8,9], bovine and porcine hokovirus [10] and Laribacter hongkongensis in ... Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus. J Virol. ... Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. Journal ...
"Coronavirus genotype diversity and prevalence of infection in wild carnivores in the Serengeti National Park, Tanzania". ...
"Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection". BMC Infect. Dis. 9: 51. ... "Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver ...
However scientists report that the genome of the coronavirus is similar to SARS only in structural and method of infection. The ... The primary differences between a coronavirus and a parmyxovirus are in their structures and method of infection, thus making ... "Coronaviruses". pathmicro.med.sc.edu. Archived from the original on 24 May 2005. Retrieved 8 March 2018.. ... The SARS coronavirus is novel, they say, but this only implies it has mutated or was previously undiscovered, not that it is ...
WHO: Novel coronavirus infection - update (13 February 2013) (accessed 13 February 2013) ... "ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway ... "Middle East respiratory syndrome coronavirus (MERS-CoV) - China". 31 May 2015.. *^ 8,0 8,1 Hubbarb, Ben; McNeill Jr., Donald G ... "Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian ...
"Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection" (PDF ... "How threatening is the new coronavirus?". BBC. 24 September 2012. Retrieved 27 September 2012. "Novel coronavirus infection" ( ... Comparison of Saudi Arabia and South Korean outbreak of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. ... "Interim Guidance - Clinical management of severe acute respiratory infections when novel coronavirus is suspected: What to do ...
Clinically, the intestinal form of the infection can sometimes be confused with coronavirus or other forms of enteritis. ... and canine coronavirus increase a dog's risk of severe infection. Dogs who catch Parvovirus usually die from the dehydration it ... This type of infection can occur when a pregnant female dog is infected with CPV2. The adult may develop immunity with little ... Three to four days following infection, the virus is shed in the feces for up to three weeks, and the dog may remain an ...
... her lab is using a mouse model to test the function and inhibition of certain proteases involved in coronavirus infection. ... Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis In this study, ... Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC (2015). "Murine coronavirus ... To find the function, structures of papain-like proteases (PLP) and domains of coronaviruses (CoVs) were studied. It was found ...
Vaccine 15 10 1101-1109 Addie D.D., Jarrett O. 1992 A study of naturally occurring feline coronavirus infection in kittens. Vet ... Addie: FIP and Coronavirus. 2013. ISBN 978-1480208971 Addie DD, le Poder S, Burr P, et al. Utility of feline coronavirus ... Prevention of FCoV infection, and therefore FIP, in kittens Kittens are protected from infection by maternally derived antibody ... aberrant immune response to infection with feline coronavirus (FCoV). FCoV is a virus of the gastrointestinal tract: most ...
Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization (англ.) // Advances ... Wong S. K., Li W., Moore M. J., Choe H., Farzan M. A 193-amino acid fragment of the SARS coronavirus S protein efficiently ... Gralinski, Lisa E.; Menachery, Vineet D. Return of the Coronavirus: 2019-nCoV (неопр.) // Viruses. - 2020. - Т. 12, № 2. - С. ... Letko, Michael; Munster, Vincent. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, ...
"Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections". New England Journal of Medicine. 368 (26): 2487-94 ... Animal viruses Human coronavirus HKU1 Human coronavirus OC43 MERS-CoV Pipistrellus Bat coronavirus HKU5 RNA virus SARS-CoV ... Pipistrellus bat coronavirus HKU5 (BtCoV-HKU5), and MERS-CoV (various species) Lineage D includes Rousettus bat coronavirus ... "Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic ...
If this occurs the infection can develop into pneumonia.[40] Several diseases, like Rat Coronavirus Infection (RCI), Sendai ... protozoic infections (e.g. Giardia muris), and pseudotuberculosis are usually seen in stressed or young rats.[37][40] ... the former is at risk of developing a pneumococcal infection from exposure to humans, while the latter may harbor tapeworms ...
1,0 1,1 Gulfaraz Khan, A novel coronavirus capable of lethal human infections: an emerging picture, Virology Journal 2013, doi: ... NOVEL CORONAVIRUS - SAUDI ARABIA (15): NEW CASE, (vaadatud 24.06.2015) *↑ NOVEL CORONAVIRUS - SAUDI ARABIA (17): 4TH CASE, ... Gulfaraz Khan,A novel coronavirus capable of lethal human infections: an emerging picture, Virology Journal 2013, 10:66 doi: ... Rapid advice note on home care for patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection presenting ...
"Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters". Journal of Virology. 79 (1): 503-11. doi: ... SARS coronavirus causes severe acute respiratory syndrome in humans. Syrian hamsters may be infected with the virus, and like ... Syrian hamsters easily contract Hantavirus species, but they do not get the same symptoms as humans, and the same infection ... Hamsters might be used to study the infection process. Leptospira viruses cause Leptospirosis in humans and similar symptoms in ...
The most common cause is viral infection and includes adenovirus, rhinovirus, influenza, coronavirus, and respiratory syncytial ... Tonsillitis is most commonly caused by a viral infection, with about 5% to 40% of cases caused by a bacterial infection. When ... the acute infection can provide retrospective evidence of GABHS infection and is considered definitive proof of GABHS infection ... and pharyngitis due to the spread of infection. An abscess may develop lateral to the tonsil during an infection, typically ...
Candida albicans infection Candida parapsilosis infection Cytomegalovirus infection diphtheria human coronavirus infection ... infection pertussis poliomyelitis prenatal Listeria Group B streptoccus infection tetanus Ureaplasma urealyticum infection ... infection Necrotizing enterocolitis Gonorrhea infection of the newborn parainfluenza (PIV) ... Lyme Disease Xerophthalmia Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections or PANDAS ...
N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects ... Kolb AF, Maile J, Heister A, Siddell SG (October 1996). "Characterization of functional domains in the human coronavirus HCV ... Kolb AF, Hegyi A, Siddell SG (November 1997). "Identification of residues critical for the human coronavirus 229E receptor ... "Human aminopeptidase N is a receptor for human coronavirus 229E". Nature. 357 (6377): 420-2. doi:10.1038/357420a0. PMID 1350662 ...
Viral infections such as canine parainfluenza or canine coronavirus are only shed for roughly 1 week following recovery; ... mixed or secondary infections can progress to lower respiratory infections such as pneumonia. The incubation period is 5-7 days ... Kennel cough is so named because the infection can spread quickly among dogs in the close quarters of a kennel or animal ... Although kennel cough is considered to be a multifactorial infection, there are two main forms. The first is more mild and is ...
The whole of replication occurs within the host cell cytoplasm and infection can even happen in cells that do not contain a ... coronavirus, notavirus, etc.) supergroup of RNA viruses. The mechanism has been best studied for the enteroviruses (which ... This was the first time that infection virus had been produced from molecular building blocks in the cells. Polyprotein ... However, as little as 30 minutes after initial infection, cell protein synthesis declines to almost zero output - essentially ...
Novel coronavirus - Status report: A new case of confirmed infection) May 12, 2013 social-sante.gouv.fr "Novel coronavirus ... Human coronavirus 229E Human coronavirus OC43 SARS-CoV Human Coronavirus NL63 (HCoV-NL63, New Haven coronavirus) Human ... Bovine coronavirus and human coronavirus OC43 diverged in 1899. Bovine coronavirus diverged from the equine coronavirus species ... Bulbul coronavirus HKU11, Munia coronavirus HKU13, Thrush coronavirus HKU12 The most recent common ancestor of the coronavirus ...
... or Feline Enteric Infection Virus (FECV). The method involves determining t ... The absence of both sites is indicative of an absence of FCoV1 infection. Compositions for use in determining infection and ... benign or mild enteric infection (Feline Enteric Infection Virus (FECV)-asymptomatic). Specific genetic determinants of these ... Although FCoV1 infection is wide-spread in domestic, feral and non-domestic cat populations world-wide (seroprevalence from 20- ...
Detection of Avian coronavirus infectious bronchitis virus type QX infection in Switzerland ... Detection of Avian coronavirus infectious bronchitis virus type QX infection in Switzerland. Journal of Veterinary Diagnostic ... Subsequently, infections with this genotype were found in several other European countries such as France, Italy, Germany, ... Subsequently, infections with this genotype were found in several other European countries such as France, Italy, Germany, ...
This is the first case of MERS-CoV infection in Greece. ... of infection with Middle East respiratory syndrome coronavirus ... Global alert and response: Coronavirus infections Updates on MERS-CoV cases worldwide ... This is the first case of MERS-CoV infection in Greece.. Individuals who had close contacts with the patient in the plane, the ... Health topics Communicable diseases Influenza Middle East respiratory syndrome coronavirus (MERS-CoV) update: Greece reports ...
2013) Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 368(26):2487-2494. ... 2004) Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived ... 2012) SARS coronavirus pathogenesis: Host innate immune responses and viral antagonism of interferon. Curr Opin Virol 2(3):264- ... 2012) Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367(19):1814-1820. ...
... caused by feline coronavirus (FCoV) infection. FCoV usually has little clinical significance; however, a mutation of... ... Addie DD (2012) Feline coronavirus infections. In: Greene CE (ed) Infectious disease of the dog and cat, 4th edn. Saunders ... Feline infectious peritonitis (FIP) is a highly fatal systemic disease in cats, caused by feline coronavirus (FCoV) infection. ... Addie DD, Schaap IAT, Nicolson L, Jarrett O (2003) Persistence and transmission of natural type I feline coronavirus infection ...
... reported an additional five laboratory-confirmed cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV ... reported an additional 5 laboratory-confirmed cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). ... This is the first case with MERS-CoV infection in the country. The Ministry of Health reported that so far no human-to-human ... Infection prevention and control measures are critical to prevent the possible spread of MERS-CoV in health care facilities. ...
... has notified WHO of a laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) in ... List of coronavirus infections DONs * Revised case definition for reporting to WHO - Middle East respiratory syndrome ... has notified WHO of a laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) in ... All Member States are reminded to promptly assess and notify WHO of any new case of infection with MERS-CoV, along with ...
WHO Interim Guidance Document - Clinical management of severe acute respiratory infections when novel coronavirus is suspected ... Infection Control Guidelines: NHMRCs Australian Guidelines for the Prevention and Control of Infection in Healthcare (2010) ... Coronaviruses are a large and diverse family of viruses that include viruses that are known to cause illness in humans ( ... Infections have occurred sporadically, as well as in a number of clusters, including a hospital-associated cluster of 23 cases ...
It is a type of Coronavirus (a family of viruses that can cause respiratory infections, including the common cold). MERS-CoV ... As of June 2017, the risk of with MERS-CoV infection to UK residents in the UK is very low. The risk of infection with MERS-CoV ... Middle East respiratory syndrome coronavirus in Qatar. As of 21 March 2017, a case in a 62 year-old resident without recent ... Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in United Arab Emirates. Between 9 and 11 April 2017, two cases of MERS ...
Feline Infectious Peritonitis (FIP) is a fatal disease in cats caused by a Coronavirus. During FIPv infection the T-cell ... As T-cell depletion during FIPv infection occurs at least partly through apoptosis, a TUNEL assay was used to evaluate this. ... These data suggest that T-cell depletion during FIPv infection does not occur through apoptosis initiated by FIPv-infected DCs ...
... of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 ... WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR ... of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 ... of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 ...
The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be ... with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same ... The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East ... Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, ...
... recognizes the surface antigen of bovine coronavirus. Bovine coronavirus (BCoV) causes severe diarrhoea in newborn ca… ... strong,Mouse anti Bovine Coronavirus Surface Antigen antibody, clone 5A4,/strong, ... It is also associated with winter dysentery in adult cattle and respiratory infections in calves and cattle. The surface ... Mouse anti Bovine Coronavirus Surface Antigen antibody, clone 5A4 recognizes the surface antigen of bovine coronavirus. Bovine ...
Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ... The identification of specific inhibitors of coronaviruses or knowledge about how coronaviruses interact with the innate immune ... making this protease an attractive target for antiviral treatments of coronavirus infection. ... I showed that HCoV-NL63 infection of bronchial epithelial cells results in a small, but measurable release of IFN-β by enzyme ...
For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus ... Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East ... Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia ( ... An ahead-of-print dispatch for the journal Emerging Infectious Diseases records research showing the coronavirus infection in ...
The video shows how the infection of monocytes by the feline Coronavirus leads to the development of the clinical signs of ... FIPV and canine coronavirus are very closely related antigenically and may have crossed between hosts. Feline coronaviruses are ... This is still not well undestood Because it was derived from the Coronavirus, history on the disease was vague, as well as any ... The ELISA, IFA, and virus-neutralization tests detect the presence of coronavirus antibodies in a cat, but these tests cannot ...
... infection in pregnancy, published by the RCOG, Royal College of Midwives, Royal College of Paediatrics and Child Health, Public ... Coronavirus (COVID-19) infection and pregnancy. Published: 13/05/2020 Coronavirus (COVID-19) infection and pregnancy Version 9 ... Guidance for healthcare professionals on coronavirus (COVID-19) infection in pregnancy, published by the RCOG, Royal College of ... Coronavirus (COVID-19): latest information and advice on GOV.UK. *Information about the virus and how to protect yourself on ...
Interim Infection Prevention and Control Recommendations for Healthcare Personnel During the Coronavirus Disease 2019 (COVID-19 ... Airborne Infection Isolation Rooms (AIIRs) (See definition of AIIR in appendix) should be reserved for patients who will be ... Information about Airborne Infection Isolation Rooms (AIIRs):. *AIIRs are single-patient rooms at negative pressure relative to ... 2. Recommended infection prevention and control (IPC) practices when caring for a patient with suspected or confirmed SARS-CoV- ...
Italys coronavirus outbreak continued to spread, bucking efforts to contain it mostly to two rural areas near Milan and Venice ... Coronavirus Infections Increase in Italy Death toll stands at 11 as experts warn the global spread of Covid-19 is reaching a ... Should You Clean Your Phone to Combat Coronavirus? Definitely... Maybe. * Government Tracking How People Move Around in ... MILAN-Italys coronavirus outbreak continued to spread, bucking efforts to contain it mostly to two rural areas near Milan and ...
... and Health in France has informed WHO of an additional laboratory-confirmed case with infection of the novel coronavirus (nCoV ... Novel coronavirus infection - update. 12 May 2013 - The Ministry of Social Affairs and Health in France has informed WHO of an ... Outbreak news on coronavirus infections * Case definition for case finding severe respiratory disease associated with novel ... additional laboratory-confirmed case with infection of the novel coronavirus (nCoV). This patient was identified as part of the ...
Russia reported 9,200 new confirmed cases of the novel coronavirus on Saturday, down from 10,598 new cases reported the ... Russias coronavirus taskforce said the overall number of cases nationwide stood at 272,043. It added that 119 people had died ... FILE PHOTO: A woman wearing a protective face mask walks in a business district amid the outbreak of the coronavirus disease ( ... MOSCOW (Reuters) - Russia reported 9,200 new confirmed cases of the novel coronavirus on Saturday, down from 10,598 new cases ...
... reported dwindling new infections on Wednesday and for the first time disclosed the number of asymptomatic cases, which could ... where the coronavirus outbreak first emerged in December, ... Asymptomatic infections would not cause a major outbreak if the ... BEIJING (Reuters) - China, where the coronavirus outbreak first emerged in December, reported dwindling new infections on ... Taxis line up outside Beijing Railway Station as the spread of coronavirus disease (COVID-19) continues in Beijing, April 1, ...
Immunopathogenesis of coronavirus infections: implications for SARS.. Perlman S1, Dandekar AA. ... On the basis of similarities with other coronavirus infections, SARS might, in part, be immune mediated. As discussed in this ... SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human disease that has ... and other pro-inflammatory cells might be particularly important in the pathogenesis of disease that is caused by infection ...
Flu shots and the risk of coronavirus infections. John Watkins is right; we need to think beyond containment, but he overlooks ... including coronaviruses. (Cowling et al, Clin Infect Dis 2012;54:1778) From Table 3, vaccine recipients had 20 noninfluenza ... placebo-controlled trial in children showed that flu shots increased fivefold the risk of acute respiratory infections caused ... it is possible that influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections ...
  • First called Novel coronavirus 2012 or simply novel coronavirus , it was first reported in 2012 after genome sequencing of a virus isolated from sputum samples from patients who fell ill in a 2012 outbreak of a new flu. (wordpress.com)
  • In fact, in older patients, coronaviruses are significant causes of "influenza-like" illnesses, acute exacerbations of chronic bronchitis, and pneumonia 1 . (einfectionmd.com)
  • During FIPv infection the T-cell population is depleted. (uu.nl)
  • As T-cell depletion during FIPv infection occurs at least partly through apoptosis, a TUNEL assay was used to evaluate this. (uu.nl)
  • These data suggest that T-cell depletion during FIPv infection does not occur through apoptosis initiated by FIPv-infected DCs. (uu.nl)
  • Rapid techniques such as reverse-transcriptase polymerase chain reaction (RT-PCR) and immunofluorescence antigen detection assays from nasopharyngeal samples can be used to detect coronaviruses. (einfectionmd.com)
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