Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Coronavirus 229E, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.Coronavirus, Bovine: A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.Spike Glycoprotein, Coronavirus: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.SARS Virus: A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.Coronavirus OC43, Human: A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.Coronavirus, Feline: A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.Coronaviridae: Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.Coronavirus, Canine: A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.Severe Acute Respiratory Syndrome: A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Murine hepatitis virus: A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).Transmissible gastroenteritis virus: A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.Infectious bronchitis virus: A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.Coronavirus NL63, Human: A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.Nucleocapsid Proteins: Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).Coronavirus, Rat: A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.Coronavirus, Turkey: A species of CORONAVIRUS causing enteritis in turkeys and pullets.Porcine Respiratory Coronavirus: A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Feline Infectious Peritonitis: Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Gastroenteritis, Transmissible, of Swine: A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Viral Proteins: Proteins found in any species of virus.Viverridae: The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.RNA Replicase: An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Enteritis, Transmissible, of Turkeys: An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.Viral Nonstructural Proteins: Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.Antigens, CD13: Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.Nucleocapsid: A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Middle East: The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)Communicable Diseases, Emerging: Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.Defective Viruses: Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.Virus Internalization: The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.Hepatitis, Viral, Animal: INFLAMMATION of the LIVER in animals due to viral infection.Chiroptera: Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.Chronology as Topic: The temporal sequence of events that have occurred.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Dysentery: Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Genes, Viral: The functional hereditary units of VIRUSES.Virus Assembly: The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.Virion: The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.Central Nervous System Viral Diseases: Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.Polyproteins: Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.Nidovirales: An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.Peptidyl-Dipeptidase A: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.Saudi ArabiaSwine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Viral Tropism: The specificity of a virus for infecting a particular type of cell or tissue.Virus Attachment: The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.Cat Diseases: Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Viral Structural Proteins: Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.Hemagglutinins, Viral: Specific hemagglutinin subtypes encoded by VIRUSES.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Camels: Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Nandiniidae: A family in the suborder Feliformia, order CARNIVORA, comprising one genus Nandinia binotata.Encephalomyelitis: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.Pneumonia, Viral: Inflammation of the lung parenchyma that is caused by a viral infection.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Common Cold: A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Arterivirus: A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.Viral Plaque Assay: Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.Papain: A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Viral Fusion Proteins: Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.Cell Fusion: Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.Helper Viruses: Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.Hong Kong: The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Zoonoses: Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Virus Diseases: A general term for diseases produced by viruses.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Host-Pathogen Interactions: The interactions between a host and a pathogen, usually resulting in disease.Frameshifting, Ribosomal: A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.Mice, Inbred BALB CDisease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Disease Reservoirs: Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.QatarProtein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Membrane Fusion: The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.Enteritis: Inflammation of any segment of the SMALL INTESTINE.Swine Diseases: Diseases of domestic swine and of the wild boar of the genus Sus.Genes, pol: DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cinanserin: A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Beluga Whale: The species Delphinapterus leucas, in the family Monodontidae, found primarily in the Arctic Ocean and adjoining seas. They are small WHALES lacking a dorsal fin.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Acetylesterase: An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.Torovirus: A genus of the family CORONAVIRIDAE characterized by enveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. Toroviruses have been found in association with enteric infections in horses (Berne virus), cattle (Breda virus), swine, and humans. Transmission probably takes place via the fecal-oral route.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Animals, ZooEncephalitis, Viral: Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.5' Untranslated Regions: The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.RNA Viruses: Viruses whose genetic material is RNA.

Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. (1/471)

Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthesized by in vitro transcription and translation from the replicase gene demonstrated both cis and trans cleavage activities for PLP-1. We have cloned and overexpressed the PLP-1 domain in Escherichia coli by using a T7 RNA polymerase promoter system or as a maltose-binding protein (MBP) fusion protein. With both overexpression systems, the recombinant PLP-1 exhibited trans cleavage activity when incubated with in vitro-synthesized viral polypeptide substrates. Subsequent characterization of the recombinant PLP-1 revealed that in vitro trans cleavage is more efficient at 22 degrees C than at higher temperatures. Using substrates of increasing lengths, we observed efficient cleavage by PLP-1 requires a substrate greater than 69 kDa. In addition, when PLP-1 was expressed as a polypeptide that included additional viral sequences at the carboxyl terminus of the predicted PLP-1 domain, a fivefold increase in proteolytic activity was observed. The data presented here support previous data suggesting that in vitro and in vivo cleavage of the ORF 1a polyprotein by PLP-1 can occur in both in cis and in trans. In contrast to the cleavage activity demonstrated for PLP-1, no in vitro cleavage in cis or in trans could be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion enzyme.  (+info)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (2/471)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability.  (+info)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (3/471)

Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA.  (+info)

Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. (4/471)

We have characterized the hemagglutinin-esterase (HE) of puffinosis virus (PV), a coronavirus closely related to mouse hepatitis virus (MHV). Analysis of the cloned gene revealed approximately 85% sequence identity to HE proteins of MHV and approximately 60% identity to the corresponding esterase of bovine coronavirus. The HE protein exhibited acetylesterase activity with synthetic substrates p-nitrophenyl acetate, alpha-naphthyl acetate, and 4-methylumbelliferyl acetate. In contrast to other viral esterases, no activity was detectable with natural substrates containing 9-O-acetylated sialic acids. Furthermore, PV esterase was unable to remove influenza C virus receptors from human erythrocytes, indicating a substrate specificity different from HEs of influenza C virus and bovine coronavirus. Solid-phase binding assays revealed that purified PV was unable to bind to sialic acid-containing glycoconjugates like bovine submaxillary mucin, mouse alpha1 macroglobulin or bovine brain extract. Because of the close relationship to MHV, possible implications on the substrate specificity of MHV esterases are suggested.  (+info)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (5/471)

This is the first report of the production of monoclonal antibodies against elk coronavirus. The nucleoprotein gene of elk coronavirus was amplified by PCR and was cloned and expressed in a prokaryotic expression vector. Recombinant nucleocapsid protein was used to immunize mice for the production of hybridomas. Twelve hybridomas that produced monoclonal antibodies against the nucleocapsid protein of elk coronavirus were selected by an indirect fluorescent-antibody test, an enzyme-linked immunosorbent assay, and a Western blot assay. Ten of the monoclonal antibodies were of the immunoglobulin G1 (IgG1) isotype, one was IgG2a, and one was IgM. All had kappa light chains. By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues. Antinucleoprotein monoclonal antibodies were found to be better at ruminant coronavirus detection than the anti-spike protein monoclonal antibodies. Because nucleoprotein is a more abundant antigen than spike protein in infected cells, this was not an unexpected finding.  (+info)

A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . (6/471)

A cysteine proteinase, papain-like proteinase (PL1pro), of the human coronavirus 229E (HCoV) regulates the expression of the replicase polyproteins, pp1a and ppa1ab, by cleavage between Gly111 and Asn112, far upstream of its own catalytic residue Cys1054. In this report, using bioinformatics tools, we predict that, unlike its distant cellular homologues, HCoV PL1pro and its coronaviral relatives have a poorly conserved Zn2+ finger connecting the left and right hand domains of a papain-like fold. Optical emission spectrometry has been used to confirm the presence of Zn2+ in a purified and proteolytically active form of the HCoV PL1pro fused with the Escherichia coli maltose-binding protein. In denaturation/renaturation experiments using the recombinant protein, its activity was shown to be strongly dependent upon Zn2+, which could be partly substituted by Co2+ during renaturation. The reconstituted, Zn2+-containing PL1pro was not sensitive to 1,10-phenanthroline, and the Zn2+-depleted protein was not reactivated by adding Zn2+ after renaturation. Consistent with the proposed essential structural role of Zn2+, PL1pro was selectively inactivated by mutations in the Zn2+ finger, including replacements of any of four conserved Cys residues predicted to co-ordinate Zn2+. The unique domain organization of HCoV PL1pro provides a potential framework for regulatory processes and may be indicative of a nonproteolytic activity of this enzyme.  (+info)

Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. (7/471)

The spike (S) glycoprotein of the Miller strain of transmissible gastroenteritis virus (TGEV) was recently cloned and expressed in baculovirus. The recombinant S protein was used as the coating antigen in a competition (blocking) enzyme-linked immunosorbent assay (ELISA) in combination with monoclonal antibodies to the S protein epitope A (conserved on TGEV and porcine respiratory coronavirus [PRCV]) or epitope D (present on TGEV only) to differentiate PRCV- from TGEV-induced antibodies. One set (set A) of 125 serum samples were collected at different times after inoculation of caesarean-derived, colostrum-deprived (n = 52) and conventional young pigs (n = 73) with 1 of the 2 porcine coronaviruses or uninoculated negative controls (TGEV/PRCV/negative = 75/30/20). A second set (set B) of 63 serum samples originated from adult sows inoculated with PRCV and the recombinant TGEV S protein or with mock-protein control and then exposed to virulent TGEV after challenge of their litters. Sera from set A were used to assess the accuracy indicators (sensitivity, specificity, accuracy) of the fixed-cell blocking ELISA, which uses swine testicular cells infected with the M6 strain of TGEV as the antigen source (ELISA 1) and the newly developed ELISA based on the recombinant S protein as antigen (ELISA 2). The sera from set B (adults) were tested for comparison. The plaque reduction virus neutralization test was used as a confirmatory test for the presence of antibodies to TGEV/PRCV in the test sera. The accuracy indicators for both ELISAs suggest that differential diagnosis can be of practical use at least 3 weeks after inoculation by testing the dual (acute/convalescent) samples from each individual in conjunction with another confirmatory (virus neutralization) antibody assay to provide valid and complete differentiation information. Moreover, whereas ELISA 1 had 10-20% false positive results to epitope D for PRCV-infected pigs (set A samples), no false-positive results to epitope D occurred using ELISA 2, indicating its greater specificity. The progression of seroresponses to the TGEV S protein epitopes A or D, as measured by the 2 ELISAs, was similar for both sets (A and B) of samples. Differentiation between TGEV and PRCV antibodies (based on seroresponses to epitope D) was consistently measured after the third week of inoculation.  (+info)

Development of an antigen spot test for detection of coronavirus in bovine fecal samples. (8/471)

We have developed a rapid and sensitive microimmunodot blot assay, the antigen spot test (AST), for the detection of bovine coronavirus (BCV) antigen from neonatal calf fecal samples. The AST procedure can be completed in 3.5 h, whereas the previously reported immunodot blot assays require 10 to 12 h. Ninety-six samples can be tested per membrane, and 10 membranes (960 samples) may be processed by a single technologist in 1 working day. The effects of detergents, oxidizing chemicals, chaotropic agents, and enzyme substrates in improving the sensitivity and signal-to-noise ratio of the AST were studied. Finally, the sensitivity and specificity of AST for the detection of BCV antigen were compared to those of a sandwich enzyme-linked immunosorbant assay (ELISA) and a hemagglutination assay (HA). Of 347 field samples tested by all three methods, 94.2% were positive by AST, 91.4% were positive by ELISA, and 86.7% were positive by HA. The sensitivity of the AST was determined to be 100% compared to the results of the ELISA reference method. The specificity of the AST was 67%, which reflects a lower limit of detection of 10(4) viral particles per ml in a 10% fecal suspension.  (+info)

Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
Between 12 and 16 October 2014, the National IHR Focal Point for the Kingdom of Saudi Arabia (KSA) notified WHO of 5 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths.
In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...
Between 13 and 14 March 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. One of these reported cases is linked to the MERS-CoV outbreak currently occurring in a hospital in Buraidah city.
We evaluated genetic variation in Middle East respiratory syndrome coronavirus (MERS-CoV) imported to South Korea in 2018 using specimens from a patient and isolates from infected Caco-2 cells. The MERS-CoV strain in this study was genetically similar to a strain isolated in Riyadh, Saudi Arabia, in 2017.
Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…
Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory disease and systemic dysfunction that may eventually lead to the death of the patients. After MERS-CoV was first diagnosed in the South Korea, in May 2015, it affected 186 individuals and claimed 37 lives in short span of time (case fatality rate = 19.9%). Compared to MERS-CoV in the Middle East, MERS-CoV in South Korea appeared to be more transmissible, and induced multiple human-to-human transmission. These knowledge gaps caused the failure of early prevention, and disseminated MERS-CoV brought out a great loss of lives and economy. The MERS-CoV outbreak revealed the potential weakness of public health system in South Korea, and promoted the reestablishment of preventive strategies for imported infectious diseases. In these regards, we analyzed the potential for additional import of re-emerged and emerging infectious diseases, such as dengue fever, malaria, chikungunya fever and hepatitis A, from Africa ...
Clinicians, laboratories and public health practitioners should be aware that many Muslims from Australia will travel to Saudi Arabia in October to undertake the Hajj between 13 and 18 October, and may travel at other times to undertake the Umrah. Health professionals should be aware of the possibility of cases in travellers returning from the Hajj which ends on 18 October 2013.. The Saudi Ministry of Health recommends that elderly people and those with chronic diseases such as heart disease, kidney disease, respiratory disease and diabetes, as well as patients with congenital and acquired immune deficiency diseases, cancer patients, pregnant women and children, defer travel to Saudi Arabia for the Umrah and Hajj this year.. WHO advises that that pre-existing major medical conditions (e.g. chronic diseases such as diabetes or chronic bronchitis, immunodeficiency) can increase the likelihood of medical problems, including MERS-CoV infection, during travel; thus, pilgrims should consult their ...
On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.
Rapid-response platforms are needed to control newly emerging virus pathogens. MERS-CoV likely emerged in the Middle East from exotic animals, perhaps bats, although the exact timing and origins of this pathogen in human populations remains unclear and is under study. MERS-CoV has caused 54 deaths at the time of writing (∼50% mortality), including documented instances of human-to-human transmission (3, 8). Therefore, the epidemic potential of MERS-CoV is high and its biology, life cycle, gene function, and pathogenic mechanisms clearly warrant additional study.. Developing full-length infectious cDNAs of emerging RNA viruses is assisted by the availability of high-throughput sequencing, gene synthesis, and the use of class II/IIS restriction endonucleases that allow seamless assembly of consensus synthetic cDNA fragments into full-length infectious cDNAs. In this instance, we synthesized a molecular clone from the published sequence, assembled full-length genomes, and isolated recombinant ...
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the
WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR Focal Point (NFP) of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 year-old...
WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...
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Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV. We also determined high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody. The structures reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they define four conformational states of the trimer wherein each receptor-binding domain is either ...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Background Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS) outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods. Methods The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods. Results The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of
1. Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N. Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis. BMC Public Health. 2016 Nov 29;16(1):1203.. 2. Dinh L, Chowell G, Mizumoto K, Nishiura H. Estimating the subcritical transmissibility of the Zika outbreak in the State of Florida, USA, 2016. Theor Biol Med Model. 2016 Nov 9;13(1):20.. 3. Nah K, Otsuki S, Chowell G, Nishiura H. Predicting the international spread of Middle East respiratory syndrome (MERS). BMC Infect Dis. 2016 Jul 22;16:356. doi: 10.1186/s12879-016-1675-z.. 4. Otsuki S, Nishiura H. Reduced Risk of Importing Ebola Virus Disease because of Travel Restrictions in 2014: A Retrospective Epidemiological Modeling Study. PLoS One. 2016 Sep 22;11(9):e0163418. doi: 10.1371/journal.pone.0163418.. 5. Nishiura H, Mizumoto K, Rock KS, Yasuda Y, Kinoshita R, Miyamatsu Y. A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection. ...
A collaborative team from The University of Texas Medical Branch at Galveston, Saudi Arabia and Canada developed a potent and safe vaccine that protects against the deadly Middle East respiratory syndrome, or MERS.
Comments, concepts and statistics about Healthcare worker infected with Middle East respiratory syndrome during cardiopulmonary resuscitation in Korea, 2015.
The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...
Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its "family tree".. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...
MERS is caused by a virus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which belongs to the Coronavirus family of viruses. MERS Virus belongs to the genus Betacoronavirus. Coronavirus family of viruses includes viruses that usually cause respiratory tract illnesses like the common cold in human beings, and also, these viruses cause a number of diseases in animals. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) causes Severe Acute Respiratory Syndrome (SARS).. Continue reading → ...
The global novel coronavirus (COVID‐19 or 2019‐CoV) issue has posed significant threats to international human health and the economy, human are fighting this novel coronavirus together. Omega-3 polyunsaturated fatty acids and antiviral treatments should be useful in fighting novel coronavirus (COVID‐19).
Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
Summary_MERS-CoV_15Apr15_final.pdf (573.1 KB) Recent evolution patterns of the Middle East respiratory syndrome coronavirus (MERS-CoV) Mazin A. Barry MD1, Sarah S. Al Subaie MD[2], Ali M. Somily MD[3], Abdulaziz A. Bin…
As more companies send employees on global travel, its important for safety and health managers to have a proper infection control system. If an employee contracts an infectious disease, the possibility of spreading it throughout the company could develop into a serious problem for the employer.. For instance, between November 2002 and July 2003, an outbreak of a terrible viral respiratory illness caused by a coronavirus occurred in South China. This disease, Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), was on the verge of becoming a pandemic. According to the World Health Organization (WHO), there were 8,098 cases and 774 deaths worldwide. In general, SARS begins with a high fever and can lead to other symptoms such as headaches, an overall feeling of discomfort and body aches. The illness spread to more than two dozen countries before the 2003 outbreak was contained.. In April 2012, a new coronavirus emerged in the Middle East: Middle East Respiratory Syndrome Coronavirus ...
We establish new minimum protein requirements for the formation of double-membrane vesicles (DMVs), a prototypic type of virus-induced membrane structure that also plays a role in the replication of other viral pathogens. We demonstrate a direct link between membrane remodelling and viral polyprotein processing and reveal the likely DMV biogenesis mechanism.. This work was done in close collaboration between the departments of Molecular Virology and Cell and Chemical Biology at the LUMC.. Oudshoorn, D., Rijs, K., Limpens, R., Groen, K., Koster, A.J., Snijder, E.J., Kikkert, M. and Barcena, M., "Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus Nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral Rna Replication" (2017) MBio, 8, 6.. ...
WHO immediately alerted all its Member States about the novel coronavirus and has been leading the coordination of and providing guidance to health authorities and technical health agencies. A joint Republic of Korea-WHO high-level mission was undertaken in June 2015 with the aim of gaining information and reviewing the situation. The team has also assessed the public health response efforts and provided its recommendations.. The IHR Emergency Committee convened by the WHO Director-General held its ninth meeting regarding MERS-CoV on 16 June 2015. The Committee concluded that the conditions for a public health emergency of international concern have not been met. WHO/Europe will continue to provide input to all aspects of this response, including participating in risk assessment, providing support to Member States that have had cases, supporting surveillance and laboratory capacities and disseminating information.. WHO/Europe in collaboration with the European Centre for Disease Prevention and ...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Since the Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in Saudi Arabia in 2012, there have been more than 2,400 confirmed cases of the infection, resulting in greater than 800 deaths - an alarming fatality rate of 35 percent. For this reason, researchers have been eager to identify any risk factors that contribute to the development of severe or lethal disease. Current clinical evidence points to diabetes as a major risk factor in addition to other comorbidities including kidney disease, heart disease, and lung disease.. Researchers from the University of Maryland School of Medicine (UMSOM) and the Johns Hopkins University School of Medicine have demonstrated in a new study, published earlier this week in the Journal of Clinical Investigation Insights, how diabetes contributes to mortality from MERS-CoV infections, and the finding could shed light on why other respiratory illnesses like the flu or pneumonia might strike those with diabetes more severely.. They ...
During the course of this project, we witnessed the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). MERS-CoV is associated with severe respiratory disease and has an exceptionally high case fatality of approximately 40%. Initially, it was not known either how efficiently the MERS-CoV could replicate on the human airway epithelium or whether any measures were available to inhibit MERS-CoV replication in the human airway epithelium, indeed, even the nature of the target cell(s) was unknown. Since primary HAE-cultures were immediately at our command, we could participate in a number of international studies. We were the first to demonstrate that MERS-CoV can efficiently replicate on the primary human epithelium, which highlights its zoonotic potential (2).. Importantly, the treatment of MERS-CoV-infected HAE-cultures with interferon-alpha and interferon-lambda significantly reduced viral replication. Hence, this strategy opens up a therapeutic option for MERS-CoV patients ...
Via InterAksyon.com, a PNA report: PH remains MERS-CoV free, but health check continues - DOH. Excerpt: Over a month after a returning overseas Filipino worker (OFW) initially tested positive for Middle East Respiratory Syndrome coronavirus (MERS-CoV), the Department of Health...
LAGOS State Government, alerted its indigenes traveling to other parts of the world with confirmed cases of coronavirus infections - a severe, life-threatening respiratory disease - to take adequate precautions to protect themselves from the infection. The coronavirus known as Middle East Respiratory Syndrome Coronavirus (MERS-CoV, is currently ravaging countries in the Middle East and…
In a surprise finding, South Korean researchers observed point mutations in MERS-CoV isolates that rendered the virus less virulent as the outbreak in that country spread last year, a finding that may have ramifications for vaccine development, according to a study today in mBio.. The scientists isolated 13 viral genomes from 14 patients infected with MERS-CoV (Middle East respiratory syndrome coronavirus) in late spring through July last year in South Korea. They found that 12 of the genomes had two specific mutations (I529T and D510G) in the receptor-binding domain (RBD) of the viruss spike protein.. They also determined that the mutations impaired viral fitness and virulence, rather than making the virus more virulent, or capable of causing severe disease.. "This is an interesting strategy of coronavirus evolution to survive in nature and live together with the new host. The virus may tune down its power to attack for the sake of longer survival in the new host," said principal investigator ...
If you would say YES to any of the above, do NOT report to NDBC. If you have traveled out of country in the past 30 days and/or been in contact with an individual with a positive laboratory COVID-19 test, you cannot be seen in person for 14 days. However, you may still be appropriate for our Telehealth program, please call Teresa at 952-800-8951.. _________________________________________________________________________. What is COVID-19..?. On February 11, 2020 the World Health Organization announced an official name for the disease that is causing the 2019 novel coronavirus outbreak, first identified in Wuhan China. The new name of this disease is coronavirus disease 2019, abbreviated as COVID-19. In COVID-19, CO stands for corona, VI for virus, and D for disease. Formerly, this disease was referred to as "2019 novel coronavirus" or "2019-nCoV".. A novel coronavirus is a new coronavirus that has not been previously identified. The virus causing coronavirus disease 2019 (COVID-19), is ...
WHO/Europe aim to reduce influenza-related morbidity and mortality by strengthening virological and epidemiological surveillance for mild and severe influenza; using surveillance data to estimate the burden of influenza in order to prioritize national influenza vaccination programmes; and maintaining and strengthening pandemic preparedness activities at the national level. WHO/Europe also monitors the emergence of other respiratory pathogens that have the potential to spread among humans. These include coronaviruses, which cause a range of illnesses from severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS-CoV) to the common cold.. ...
Every virus needs a catchy name, and now the new coronavirus linked to the Middle East that has infected 40 people and killed half of them has one: Middle East Respiratory Syndrome Coronavirus or (MERS-CoV). Various scientists have been calling it MERS,
Tse, L.V., Marcano, V.C., Huang. W., Pocwierz, M.S. and Whittaker, G.R. (2013). Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin independent of the viral neuraminidase. J. Virol. 87: 5161-5169 Licitra, B.N., Sams, K.L. Lee, D.W. and Whittaker G.R. (2014). Feline coronaviruses associated with feline infectious peritonitis have modifications to spike protein activation sites at two discrete positions. ArXiV.http://arxiv.org/abs/1412.4034. Costello, D.A., Whittaker, G.R. and Daniel, S. (2015).Variation of pH sensitivity, acid stability, and fusogenicity of three influenza H3 subtypes. J. Virol. 89(1):350-360.http://www.ncbi.nlm.nih.gov/pubmed/25320308. Millet, J.K. and Whittaker, G.R. Host cell entry of Middle East respiratory syndrome coronavirus following two-step, furin-mediated activation of spike protein. Proc Natl Acad Sci.:http://www.pnas.org/content/early/2014/10/02/1407087111.abstract Hamilton, B.S., Chung, C., Cyphers, S., Rinaldi, V.D., Marcano, V., and ...
Russia has confirmed its first two cases of the novel coronavirus on Friday in the Trans-Baikal and Tyumen regions.. The patients are Chinese nationals who have been hospitalized and are in stable condition, said Anna Popova, head of Russias consumer rights and human wellbeing watchdog Rospotrebnadzor.. Russia will take measures to prevent the spread of the novel coronavirus in the country, said Russian Deputy Prime Minister Tatyana Golikova, adding the country is ready to offer assistance to China.. ...
Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to estimate rates of morbidity and mortality and to examine predictors of severity among participants with 2009 H1N1 infection. In 2011, as surveillance indicated that 2009 H1N1 virus was co-circulating with other seasonal influenza A and B viruses worldwide, the protocol was expanded to include other influenza A subtypes and influenza B viruses. The current version of the protocol (released in August 2013) further broadens the scope of this observational study. With the recognition that novel respiratory viruses other than novel influenza A viruses, e.g., Middle East Respiratory Syndrome Coronavirus (MERS-CoV), could become prevalent and of major public health importance, the objectives of this protocol have been expanded ...
People with diabetes are at a higher risk of various complications, including worse respiratory diseases. One of the most dreaded lung diseases is the Middle East respiratory syndrome coronavirus (MERS-CoV), which emerged in Saudi Arabia in 2012.
A senior World Health Organization official announced that the United Nations agency would convene an emergency committee to plan for a possible escalation in illnesses caused by the Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. Dr. Keiji Fukuda, assistant director general for health...
A new study suggests that the Middle East Respiratory Syndrome coronavirus (MERS-CoV) develops mutations that make the virus less virulent during an outbreak rather than more virulent. The study, published this week in mBio, an online open-access journal of the American Society for Microbiology, has implications for vaccine development.
Zymo Research Corp. announced on Monday that it released its DNA/RNA Shield, a viral inactivation solution that can help to transport viruses including Ebola and Middle East Respiratory Syndrome coronavirus (MERS-CoV).
The University of Queenslands Australian Institute for Bioengineering and Nanotechnology (AIBN) has appointed a new director following an international search.. Professor Alan Rowan will join UQ in January, taking over from AIBNs inaugural director, Professor Peter Gray.. UQ Vice-Chancellor and President Professor Peter Høj said Professor Grays leadership since 2003 had helped position AIBN as a major research institute of international standing, employing almost 500 people.. "Weve seen significant success stories, including Nanopatch vaccine technology, the manufacture of an antibody used in world-first human Hendra virus clinical trials, and collaboration between AIBN and American researchers to tackle the growing global threat of Middle East respiratory syndrome coronavirus (MERS-CoV)," Professor Høj said.. "The nanotechnology research at AIBN has had broad reaching application, from ground-breaking advancements in green energy technologies to targeted drug delivery.. Professor Rowan ...
CIDRAP News) - Jordans health ministry has sent 124 respiratory samples it collected from suspected Middle East respiratory syndrome coronavirus (MERS-CoV) cases, none of which appear to be recent infections, to the US Centers for Disease Control and Prevention (CDC) for testing, the agency said today. ...
The epidemic of severe acute respiratory syndrome (SARS) was caused by a newly emerged coronavirus (SARS-CoV). Bats of several species in southern Peoples Republic of China harbor SARS-like CoVs and may be reservoir hosts for them. To determine whether bats in North America also harbor coronaviruses, we used reverse transcription-PCR to detect coronavirus RNA in bats. We found coronavirus RNA in 6 of 28 fecal specimens from bats of 2 of 7 species tested. The prevalence of viral RNA shedding was high: 17% in Eptesicus fuscus and 50% in Myotis occultus. Sequence analysis of a 440-bp amplicon in gene 1b showed that these Rocky Mountain bat coronaviruses formed 3 clusters in phylogenetic group 1 that were distinct from group 1 coronaviruses of Asian bats. Because of the potential for bat coronaviruses to cause disease in humans and animals, further surveillance and characterization of bat coronaviruses in North America are needed ...
The Centers for Disease Control and Prevention (CDC) is closely monitoring an outbreak of respiratory illness caused by the new coronavirus first identified in Wuhan, China. Chinese authorities identified the first four cases of the new virus Dec, 31, 2019. It is believed the virus originated at a wet food market, where it likely mutated in an animal and made the jump to humans. Chinese health authorities tested the pathogen and found it belongs to the coronavirus family. This is the same family of viruses that include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). These viruses are spreads via airborne droplets.. The first fatality from the virus was on Jan. 9, 2020. In the three weeks since then, in China the death toll has risen to more than 213, and the number of confirmed cases was at 9,900 as of Jan. 31. About 130 cases were reported outside of China in 22 other countries.. The first cases reported outside of China were reported starting on Jan. 13. ...
The Middle East Respiratory Syndrome Coronavirus, better known as MERS, may be an airborne virus, according to an observation paper published Tuesday in the journal mBio.. 12NewsNow Story
One of the earliest known victims of the Middle East Respiratory Syndrome coronavirus -- a retired Saudi military man who owned a herd of camels outside of ...
An Illinois man has contracted the Middle East respiratory syndrome coronavirus from the Indiana patient who was recently hospitalized, marking the first confirmed human-to-human transmission of MERS within the U.S.. 0 Comments. ...
An Illinois man has contracted the Middle East respiratory syndrome coronavirus from the Indiana patient who was recently hospitalized, marking the first confirmed human-to-human transmission of MERS within the U.S.. 0 Comments. ...
Coronaviruses are a broad family of viruses that cause upper-respiratory illnesses, ranging from the common cold to severe viruses. Novel coronavirus (nCoV) is a new strain that has not been previously identified in humans. Coronaviruses are zoonotic, they are transmitted between animals and people.
This interim guidance is based on what is currently known about the 2019 novel coronavirus (2019-nCoV). The Centers for Disease Control and Prevention (CDC) will update this interim guidance as needed and as additional information becomes available.. CDC is working across the Department of Health and Human Services and across the U.S. government in the public health response to 2019-nCoV. Much is unknown about how the 2019-nCoV spreads. Current knowledge is largely based on what is known about similar coronaviruses.. Coronaviruses are a large family of viruses that are common in humans and many different species of animals, including camels, cattle, cats, and bats. Rarely, animal coronaviruses can infect people and then spread between people, such as with MERS and SARS. 2019-nCoV is spreading person-to-person in China and some limited person-to-person transmission has been reported in countries outside China, including the United States. However, respiratory illnesses like seasonal influenza, ...
Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). Methods: 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. Results: The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years).They were divided to 26 common type and 4 severe cases, all of whom had close(within 1m) contact with patients infected of novel coronavirus pneumonia. The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 ...
The main symptoms are a fever, a dry cough, shortness of breath, or trouble breathing. MERS may also cause a headache, muscle aches, a sore throat, fatigue, and diarrhea or there may be no symptoms at all. For some people the symptoms get worse quickly, so they may need to stay in the hospital. The incubation period-the time from when a person is first exposed to MERS until symptoms appear-is usually 5 to 6 days, but it may be as long as 14 days.. If you have symptoms of the illness, do not go to a health facility without calling first. Calling first will help the health care team take better care of you and protect others from the illness. ...
Dr. Thoma walks us through the deadly MERS outbreak that has finally hit the US. So far its limited to Indiana. Far too little is known about the syndrome.
The facts of this incident have not been clearly written and require verification.] On 26 May 2015, a 44-year-old South Korean man, his father and elder sister [were all] confirmed to be infected by MERS. [The 44-year-old man], paying no notice to a doctors advice [plus] a self-quarantine order from the government, travelled via Hong Kong to Huizhou China for a business trip. When he was later found to have a fever, he was suspected of being dishonest with border quarantine officers in Hong Kong by concealing that he had visited his father in hospital on 16 May for nearly 4 hours.[21] He tested positive for MERS.[22]. On 30 May 2015, a website said that a driver in Huizhou who transported a South Korean male MERS patient was suspected to be infected but later the government clarified that this was a rumor.[23]. A Chinese fugitive who stayed in South Korea for 3 years turned himself in as he was afraid of the outbreak. He arrived at Dalian Zhoushuizi International Airport on 4 June.[24]. On 8 ...
At low concentrations, an inhibitor activates MERS 3C-like protease enzyme, but higher concentrations successfully blocks the activity of the enzyme.
The other two cases involve a couple from Wuhan, who are a 62-year-old woman and a 63-year-old man with good past health. According to the information they provided, they took High-Speed Rail from Wuhan at 2.20pm on January 22 and arrived at the Hong Kong West Kowloon Station of the Guangzhou-Shenzhen-Hong Kong Express Rail Link at around 8pm that evening. The woman developed fever on January 23 while her husband developed cough on the same day and then fever on January 24. The couple attended the Prince of Wales Hospitals A&E Department on January 23 and were admitted for isolation. They are in stable condition. The respiratory samples of both patients were tested positive for novel coronavirus ...
What is COVID-19? Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans.. The World Health Organization states that most people who become infected experience mild illness and recover, but it can be more severe for others. [1] Here is a link to the Center for Disease Prevention Fact Sheet for coronavirus disease (COVID-19).. Are pregnant women more vulnerable to COVID-19? The United Nations Fund states that, to date, there is no scientific evidence about the increased susceptibility of pregnant women to COVID-19. They went on to state, however, that "pregnancy brings physical changes that might make some pregnant women more susceptible to viral respiratory infections. Pregnant women with respiratory illnesses must be treated with the ...
10 February). As of 9 February, in mainland China, 40,171 confirmed cases had been reported, among which 3,281 were cured and discharged from hospital, 908 died, and 35,982 still under treatment. There was 23,589 suspected cases pending test results in mainland China as of 9 February. Official statistics show that between 4 and 9 February, the number of newly reported confirmed cases outside Hubei province kept declining for six consecutive days. By 9 February, no confirmed or suspected case of novel coronavirus infection had been reported among Tanzanian citizens in China and no such case reported in Tanzania either.. By 5 February, leaders of 61 countries, including Tanzanian President Dr. John Pombe Magufuli, and heads of eight international organizations wrote letters to President Xi Jinping, Premier Li Keqiang and other members of the Chinese leadership to express solidarity and support. They spoke openly in support of China and commended Chinas epidemic control efforts. An advance team of ...
Good evening,. As your Town Supervisor, I wanted to share the following information, prepared by the CDC, to provide you with helpful answers to some frequently asked questions about the coronavirus. Although there are currently no confirmed cases of the virus in Nassau County, out of an abundance of caution, and in the interest of prevention, I felt it was important to help keep you informed. Please feel free to share this note with your friends and family.. Q: What is a novel coronavirus?. A: A novel coronavirus is a new coronavirus that has not been previously identified. The virus causing coronavirus disease 2019 (COVID-19), is not the same as the coronaviruses that commonly circulate among humans and cause mild illness, like the common cold.. Q: What are the symptoms of COVID-19?. A: Current symptoms reported for patients with COVID-19 have included mild to severe respiratory illness with fever, cough, and difficulty breathing.. Q: What is the source of the virus?. A: Coronaviruses are a ...
A new study that uses 3D modelling to compare the novel coronavirus with SARS shows that it can bind to human cells more strongly than its predecessor due to a structural mutation, which researchers say could be key knowledge in the search for a vaccine.
The authors report on the findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong, after visiting Wuhan, plus an additional family member who did not travel to Wuhan. Of six family members who travelled to Wuhan, five were identified as having been infected with the 2019 novel coronavirus (2019-nCoV). In addition, one family member, who did not travel to Wuhan, became infected after several days of contact with four of the family members. None of the family members had contact with Wuhan markets or animals, although two had visited a Wuhan hospital. Five members, aged 36-66 years, presented with fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3-6 days following exposure. They presented to a hospital 6-10 days following symptom onset. They, and one asymptomatic child (aged 10 years), had radiological ground-glass lung opacities. Older patients (aged ,60 years) had more systemic ...
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named 2019 novel coronavirus (2019-nCoV) by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and qui …
COVID-19/Coronavirus (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been prev ...
Patients with novel coronavirus pneumonia have characteristic CT features in the initial stage of infection, which can be used as an essential supplement for nucleic acid examination.
TORONTO -- A Toronto hospital says a man with novel coronavirus who was being treated there has now been discharged and is recovering at home.. The man in his 50s travelled to Toronto from China last week and was Canadas first case of the virus.. There are three confirmed cases in the country -- another Ontario case is the first patients wife, and there is one in British Columbia -- all are linked to recent travel.. Sunnybrook Health Sciences Centre says in a statement today that the mans health has improved over the past week to the point where he no longer requires in-patient care.. ...
We have formed an Emergency Response Task Group to monitor the situation regarding the spread of COVID-19 and its consequences. This novel coronavirus outbreak has the potential to show the value and impact of scientific collaboration.
An analysis of about 1,000 cases of clustering infections of the novel coronavirus shows that 83 percent have occurred in families, a leading epidemiologist said on Tuesday.. Hospitals, schools, shopping malls, factories and enterprises also are high-risk places for clustering infections - a definition that refers to more than two infections at a small place, said Wu Zunyou, chief epidemiologist at the Chinese Center for Disease Control and Prevention.. About 22 percent of the clustering infections were transmitted from patient zero to other patients, and 64 percent of infections are transmitted from those patients to more patients, he said, adding that there have also been rare cases of third-generation or fourth-generation transmission when the first patient has not shown clear symptoms.. The first patient usually has lived or traveled to Wuhan, and through close contact, the patients family member was infected, which then can be transmitted to more family members, he said at a daily news ...
The Centre for Health Protection (CHP) of the Department of Health said today (January 14) that the CHP has been closely monitoring a new confirmed case of infection of novel coronavirus...
Health information for Novel Coronavirus (COVID-19) for Waterloo Region residents. Including information about symptoms, treatment, and how to protect yourself.
The TGA has identified certain therapeutic goods being inappropriately promoted for the prevention or treatment of novel coronavirus (2019-nCoV) infections in Australia
The Centers for Disease Control and Prevention announced two new patients now have the 2019 Novel Coronavirus (2019-nCoV), bringing the case total in the United
South Korea now has over 4,000 confirmed cases of the novel coronavirus, after the government reported nearly 600 new cases on March 2.
The novel SARS-CoV-2 coronavirus that has recently been in the news is a virus that has not been previously identified. The virus currently causing coronavirus disease (COVID-19) is not the same as the coronaviruses that commonly circulate among humans and cause mild illness, like the common cold.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Nearly three-quarters of Coloradans are very concerned about the novel coronavirus and taking recommended precautions such as social distancing and hand-washing - even as younger people continue to be less troubled by the global outbreak.. These attitudes are illuminated in a state health department survey released Saturday, which polled nearly 45,000 Coloradans on a variety of COVID-19-related questions.. The survey - conducted between Sunday and Tuesday, before Gov. Jared Polis ordered residents statewide to stay at home - showed 72% of respondents were "very concerned" about COVID-19 in Colorado. Among 18- to 29-year-olds, however, that number dropped to 59%.. That lack of concern among some did not come from a belief that they wouldnt get sick, the survey showed. Nearly 90% of respondents said they think its somewhat or very likely that they would get sick from the novel coronavirus. ...
by Peter Openshaw, PhD. Coronaviruses cause about 15% of common colds, which are normally mild. So why are public health authorities so alarmed about the latest coronavirus disease, Middle East Respiratory Syndrome (MERS)?. With the first reports of person to person transmission, MERS-CoV is uncomfortably reminiscent of the Severe Acute Respiratory Syndrome (SARS)-CoV, which emerged in South […]. ...
Coronavirus is an airborne virus, spread in a similar way to colds and the flu.. The virus attacks the respiratory system, causing lung lesions.. Symptoms include a runny nose, headache, cough and fever, shortness of breath, chills and body aches.. It is incredibly contagious and is spread through contact with anything the virus is on as well as infected breath, coughs or sneezes.. In most cases, you wont know whether you have a coronavirus or a different cold-causing virus, such as rhinovirus.. But if a coronavirus infection spreads to the lower respiratory tract (your windpipe and your lungs), it can cause pneumonia, especially in older people, people with heart disease or people with weakened immune systems.. There is no vaccine for coronavirus.. In 2003 an outbreak of a similar virus, SARS, infected more than 8,000 people in 37 countries before it was brought under control, killing 800 of those worldwide.. ...
The fatal case was reported from Al-Qaseem region in the Central part of the country and is not related to the cluster of cases reported from Al-Ahsa region in the Eastern part of the country. The patient was a 63-year-old man with an underlying medical condition who was admitted to a hospital with acute respiratory distress on 15 May 2013 and died on 20 May 2013. Investigation into contacts of this case is ongoing ...
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the Middle East Respiratory Syndrome, Severe Acute Respiratory Syndrome, and 2019-nCov. Coronaviruses can spread from animals to humans. Symptoms include fever, cough, shortness of breath, and breathing difficulties. In more severe cases, it can lead to death. Here is the latest research on coronaviruses. ...
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the Middle East Respiratory Syndrome, Severe Acute Respiratory Syndrome, and 2019-nCov. Coronaviruses can spread from animals to humans. Symptoms include fever, cough, shortness of breath, and breathing difficulties. In more severe cases, it can lead to death. Here is the latest research on coronaviruses. ...
The coronavirus pandemic has had a highly negative impact on most stocks in the market, but there are some stocks that have actually rocketed under the current circumstances. One such stock is that of Co-Diagnostics Inc (NASDAQ:CODX), which has rallied by as much as 1450% since January and has emerged as one of the stocks to watch. Stock Outperformed The stocks performance is particularly remarkable considering the fact that the economy has gone into recession. Much of the bullishness is centered on the companys coronavirus tests, and it could be worthwhile to figure out if there is any more upside to the Co-Diagnostics stock. Testing has been one of the most in-demand services at the time of the coronavirus pandemic, and that has resulted in the strong Co-Diagnostics stock rally. On top of that, the company revealed on May 1 that its coronavirus test recorded perfect sensitivity and specificity scores in detections tests. That resulted in another 19% rally in the stock price. Co-Diagnostics ...
TY - JOUR. T1 - Analysis of the CIS-acting elements of coronavirus transcription. AU - Joo, M.. AU - Makino, Shinji. PY - 1994. Y1 - 1994. UR - http://www.scopus.com/inward/record.url?scp=0028326927&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028326927&partnerID=8YFLogxK. M3 - Article. VL - 342. SP - 91. EP - 97. JO - Advances in Experimental Medicine and Biology. JF - Advances in Experimental Medicine and Biology. SN - 0065-2598. ER - ...
Currently, no protective vaccine is available against the coronavirus strain responsible for Middle East Respiratory Syndrome (MERS). The need for such a vaccine is underlined by the current outbreak of the disease in South Korea, which has led to the infection of over 150 people and has already caused several deaths. Two years ago, a team of researchers led by Professor Gerd Sutter, who holds the Chair of Virology at LMUs Institute for Infectious Diseases and Zoonoses, reported that it had developed a candidate vaccine directed against the MERS-CoV. Further preclinical tests have confirmed its efficacy, as the team now reports in the "Journal of Virology". These results lead the way for Phase I clinical trials, which will determine how well the vaccine is tolerated by human subjects.. The vaccine candidate, named MVA-MERS-S, was developed by Sutters group in collaboration with colleagues based at Marburg University and the Erasmus Medical Center in Rotterdam. It is based on the use of a ...
Middle East Respiratory Syndrome, or MERS, is similar to another deadly coronavirus identified a decade ago called Severe Acute Respiratory Syndrome, giving scientists a jump on the investigation into their origins.
The first patient developed respiratory symptoms and fever 14 days after admission to hospital for an unrelated reason. He died 11 days later with multi-organ failure. Two of his brothers presented later to another hospital with respiratory symptoms and fever. MERS-CoV infection in the latter 2 patients was confirmed by reverse transcriptase polymerase chain reaction testing. All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine transaminase. No hospital or other social contacts are known to have acquired the infection. It appears that the index patient in this cluster acquired MERS-CoV infection whilst in hospital from an unrecognized mild or asymptomatic case.. ...
Coronaviruses: Genome Structure, Replication, And .... Those with the active IC resulted in death of mice; and those with mutant E gene lacking IC activity, generally resulted in recovery and survival of the mice [10]. Airborne infections are those that are transmitted with flying pathogens that are in the wind.represents the expected peak of antibody titers and implies that there will be diminished protection against SARS-CoV over time." Coronaviruses are a family of viruses that have spikes on their surface that make them look like little crowns as you can see in this photo:.. Coronavirus - An Overview , ScienceDirect Topics. Data represent one experiment for both Vero and HAE cells.M glycoprotein helps in the attachment of the nucleocapsid to the membranes of internal structures such as the Golgi Body.8 was able to achieve 50% neutralization of SHC014-MA15, but only at high concentrations (10 μg/ml) (Fig.If you have this blood disorder, you can also expect to feel things like fatigue, ...
Screening for the novel coronavirus is now part of our influenza surveillance programme. While coronavirus is not something new, the MERS-CoV strain had not been identified in humans earlier. The reason it is being feared is because of its severity as more than 60% infected persons have died. Also, little is known about it so far like transmission and clinical impact," said Dr D T Mourya, director, NIV. ...
As of midnight, February 18th, Guangdong had reported 3 new cases of the coronavirus (COVID-19), all from Huizhou, pushing the total number of infected patients to 1331. No new cases were confirmed in other cities ...
Here are the latest numbers of coronavirus infections and deaths, and the number of people being monitored for potential COVID-19.. The number of patients diagnosed with COVID-19 grows every day throughout the U.S. and across the world. Experts expect the number of U.S. cases to continue to rise in the coming weeks as more testing detects new infections. The numbers on this page are based on the latest statistics available. Heres the situation as it stands: Heres a daily snapshot of the number of active cases, recoveries and deaths as testing expands across the country:. Coronavirus patients reported in the US: There are a variety of sources tracking the virus, and for this story, we rely on data from Johns Hopkins University. It cross-checks reports from a number of sources, including the Centers for Disease Control and Prevention, and publishes updates several times each day.. New confirmed coronavirus patients reported in the US by day: You can keep track of the latest totals for your state ...
The novel coronavirus disease (COVID-19) is characterized by CT findings that...Read more on AuntMinnie.comRelated Reading: CT findings for coronavirus may overlap with adenovirus How does COVID-19 differ from other coronaviruses? What do radiologists need to know about the coronavirus? CT again tops DNA tests for early coronavirus detection CT proves vital for early diagnosis of COVID-19...
The South Korean government on Monday declared the Middle East Respiratory Syndrome (MERS) coronavirus outbreak was virtually over.
Promising data for candidate vaccines against Zika virus infection reported by Abbink et al. (1) on page 1129 of this issue raise hopes that one or more Zika virus vaccines may soon be ready for efficacy trials. Recent years have seen a barrage of emerging infectious diseases, including those caused by new pathogens such as Middle East respiratory syndrome (MERS) coronavirus, and those that are newly salient because of increased geographic spread, higher incidence, or genetic change, such as influenza A(H1N1)pdm09, Ebola virus, and Zika virus. Developing effective vaccines is a central goal for such pathogens.Authors: Marc Lipsitch, Benjamin J. Cowling
Acknowledgment: The authors thank the members of the Department of Clinical Nursing and the Infection Prevention and Control Program, King Abdulaziz Medical City, Riyadh, Saudi Arabia, for their assistance. They also thank the following persons: From the King Saud bin Abdulaziz University for Health Sciences, Riyadh: Sameera Johani, MD, Division of Microbiology, Pathology & Laboratory Medicine; Abdullah Ghamdi, MD, Department of Cardiac Sciences; Ghassan A. Al-Ghamdi, MD, Intensive Care Department and Assistant Professor, College of Medicine; Saqib I. Dara, MD, Intensive Care Department; Raed A. Hijazi, MD, Emergency Medicine; Olivia A. Trinidad, RRT, Edgardo Tabhan, RRT, and Charina Olay, RRT, all Respiratory Therapist I, Respiratory Services. From the King Abdulaziz Hospital, Al-Ahsa: Yusri Taha, MD, and Mohammed Ayman El Gammal, MD, Infectious Diseases, Department of Medicine and Abdulsalam Al-Aithan, MD, Pulmonary & Intensive Care Medicine. From the Imam Abdulrahman Bin Faisal Hospital, ...
Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a newly recognized coronavirus (MERS-Co). It was first reported in 2012 in Saudi Arabia and since then linked to countries in or near the Arabian Peninsula (United Arab Emirates, Qatar, Oman, Jordan, Kuwait, Yemen, and Lebanon) and Iran. As of May 2014, two cases had been reported in the United States, both in men who had recently returned from Saudi Arabia (1). Also Iran has been reported plenty of cases but fortunately the outbreak subsided (2).. Recently South Korea had a large outbreak of the MERS and was blamed on locating every person exposed to the disease. Many of the 180 MERS cases in South Korea, which make up the largest outbreak of the disease outside Saudi Arabia, were caught from sufferers encountered in emergency wards before they were diagnosed, during a wait for hospital places; unfortunately 30 out of 180 infected patients expired (3).. MERS is typically characterized by cough, fever, and shortness of ...
Interest in porcine epidemic diarrhea has grown since the 2013 outbreak in the United States caused major losses, with mortality rates up to 100 % in suckling piglets. In Mexico, an outbreak of porcine epidemic diarrhea, characterized by 100 % mortality in piglets, began in March 2014 in the State of Mexico. The aim of this study was to confirm and identify porcine epidemic diarrhea virus (PEDV) in samples from piglets with suggestive clinical signs using virological, histological, and molecular techniques. Necropsy was performed on 13 piglets from two litters with initial and advanced clinical signs. Suggestive lesions of acute infection with PEDV were detected in histological sections of the small and large bowels; specifically, multiple virus particles with visible crown-shaped projections were observed using electron microscopy and negative staining. Viral isolation was performed in Vero cells with trypsin. Infection was monitored by observation of cytopathic effect, and titration was ...
BROOKINGS - South Dakota swine producers and veterinarians have been closely monitoring the developments surrounding Porcine Epidemic Diarrhea (PED) virus infections over the past several months.
HUMAN coronaviruses (HCV) in two serogroups represented by HCV-229E and HCV-OC43 are an important cause of upper respiratory tract infections1. Here we report that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells2-5, is a receptor for human coronavirus strain HCV-229E, but not for HCV-OC43. A monoclonal antibody, RBS, blocked HCV-229E virus infection of human lung fibroblasts, immunoprecipitated aminopeptidase N and inhibited its enzymatic activity. HCV-229E-resistant murine fibroblasts became susceptible after transfection with complementary DNA encoding human aminopeptidase N. By contrast, infection of human cells with HCV-OC43 was not inhibited by antibody RBS and expression of aminopeptidase N did not enhance HCV-OC43 replication in mouse cells. A mutant aminopeptidase lacking the catalytic site of the enzyme did not bind HCV-229E or RBS and did not render murine cells susceptible to HCV-229E infection, suggesting that the virus-binding site may
An image from the new review article by Kansas State University swine disease researchers in the College of Veterinary Medicine has been featured on the cover of the latest issue of the international journal Transboundary and Emerging Diseases: "Swine enteric coronavirus disease: A review of four years with porcine epidemic diarrhea virus and porcine deltacoronavirus in the United States and Canada.". In their article, Megan Niederwerder, assistant professor of diagnostic medicine and pathobiology, and Dick Hesse, professor and director of diagnostic virology, review the recent introduction and spread of porcine epidemic diarrhea virus, or PEDV, and porcine deltacoronavirus, or PDCoV, in the United States and Canada.. Although these two viruses were recently introduced in 2013 and 2014, respectively, both viruses are now endemic in United States swine herds. The authors review current and historical research on the viruses, including clinical disease in different age groups, postinfection viral ...
Under freezing conditions (−10 °C) an AHP disinfectant prepared in a 10% PG solution inactivated PEDV in the presence of feces on metal surfaces. Both AHP disinfectant dilutions (1:16 and 1:32), and contact times (40 min and 60 min) evaluated were sufficient to inactivate PEDV at either fecal load (5 mL and 10 mL), under the conditions of this study. Bioassay results from this study support previous work where the same AHP disinfectant successfully inactivated PEDV in swine feces on metal surfaces at 20 °C [13]. Findings from this study demonstrate that manually removing the organic material from a trailer via scraping and then applying an AHP disinfectant may be an effective alternative to doing nothing between loads, year round. Additionally, mixing the AHP disinfectant in a 10% PG solution prevented the disinfectant solution from freezing during 40 or 60 min of contact time in a freezer set to -10 °C, supporting previously published data on utilizing PG as an anti-freezing agent [10, ...
FELINE INFECTIOUS PERITONITIS Navies 2011 Feline Infectious Peritonitis (FIP) is a progressive, almost always fatal, viral disease of domestic cats. It affects some exotic cats, with the cheetah being particularly susceptible. It does not affect non-feline species, such as dogs. Etiology or Cause      Field strains of feline coronavirus vary in their ability to induce FIP. Some isolates cause FIP (feline infectious peritonitis virus [FIPV]others cause more localized GI disease) Mutations from feline enteric coronavirus to FIPV occur. FIP is thought to result from a mutation of the virus within the body, combined with the response of the immune system, leading to inflammation in various organ systems. FIPV and canine coronavirus are very closely related antigenically and may have crossed between hosts. Feline coronaviruses are fairly stable in the environment and, once dry, can survive for 4-6 wk. They are enveloped viruses and are destroyed by most household disinfectants, ...
Infectious bronchitis, a disease of chickens caused by Avian coronavirus infectious bronchitis virus (IBV), leads to severe economic losses for the poultry industry worldwide. Various attempts to control the virus based on vaccination strategies are performed. However, due to the emergence of novel genotypes, an effective control of the virus is hindered. In 1996, a novel viral genotype named IBV-QX was reported for the first time in Qingdao, Shandong province, China. The first appearance of an IBV-QX isolate in Europe was reported between 2003 and 2004 in The Netherlands. Subsequently, infections with this genotype were found in several other European countries such as France, Italy, Germany, United Kingdom, Slovenia, and Sweden. The present report describes the use of a new set of degenerate primers that amplify a 636-bp fragment within the S1 gene by reverse transcription polymerase chain reaction to detect the occurrence of IBV-QX infection in Switzerland. ...
Impact of 2019-20 coronavirus pandemic[edit]. The 2020 season was disrupted by the 2019-20 coronavirus pandemic, which was ... As the coronavirus situation develops, the AFL has advised that only the first four rounds will be played as originally drawn, ... On 22 March 2020, the season was suspended at the conclusion of Round 1 due to the 2019-20 coronavirus pandemic.[1] ... This was a result of various Australian state governments announcing the closure of their borders due to the coronavirus.[1] ...
... a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the ... the novel coronavirus'.[102] References[edit]. *^ Parry RL (10 June 2015). "Travel alert after eighth camel flu death". The ... "MERS-CoV , Prevention and Treatment of MERS , Coronavirus , CDC". www.cdc.gov. 13 July 2016. Retrieved 4 April 2017.. ... Butler D (October 2012). "SARS veterans tackle coronavirus". Nature. 490 (7418): 20. doi:10.1038/490020a. PMID 23038444.. ...
IV: SARS coronavirus *Severe acute respiratory syndrome. *V: Orthomyxoviridae: Influenzavirus A/B/C/D *Influenza/Avian ...
"Fang Bin is second Chinese citizen journalist to vanish while reporting from coronavirus epicentre". South China Morning Post. ... "Coronavirus: Why have two reporters in Wuhan disappeared?". BBC. February 14, 2020.. ... "Lawyer Chen Qiushi documenting coronavirus epicentre disappears". South China Morning Post. February 10, 2020.. ... "Coronavirus: journalist missing in Wuhan as anger towards Chinese authorities grows". The Guardian ...
human coronavirus infection. *respiratory distress syndrome. *measles. *meconium aspiration syndrome. *metapneumovirus (hMPV) ...
Coronavirus pandemic in Malaysia. 2020. 2020 Political Crisis. 2020. Movement Control Order. 2020. ...
Peiris JS, Poon LL (2011). Detection of SARS Coronavirus. Methods in Molecular Biology. 665. pp. 369-82. doi:10.1007/978-1- ...
"Coronaviruses". pathmicro.med.sc.edu. Archived from the original on 24 May 2005. Retrieved 8 March 2018.. ... Coronaviruses similar to SARS have been found in bats in China, suggesting they may be their natural reservoir.[19] However ... The SARS coronavirus is novel, they say, but this only implies it has mutated or was previously undiscovered, not that it is ... "SARS-like coronavirus found in wild bats: scientists". The People's Daily. 11 September 2005. Retrieved 2007-08-16.. ...
Wuhan coronavirus: Lunar New Year Cup cancelled by government just hours after HKFA promotes the event ...
Nanshan Zhong - Discovered the SARS coronavirus. *O. James Garden - Performed the first liver transplant in Scotland ...
"MERS coronavirus in dromedary camel herd, Saudi Arabia". Emerging Infectious Diseases. 20 (7): 1-4. doi:10.3201/eid2007.140571. ... coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013". Eurosurveillance. 18 (50): 20659. doi:10.2807/ ... in Egypt was the first to show the dromedary might be a host for the Middle East respiratory syndrome coronavirus (MERS-CoV).[ ... "Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high ...
"Coronavirus pathogenesis". Adv. Virus Res. Cilt 81, s. 85-164. doi:10.1016/B978-0-12-385885-6.00009-2. PMID 22094080 ...
... a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the ... "MERS-CoV , Prevention and Treatment of MERS , Coronavirus , CDC". www.cdc.gov. 13 July 2016. Retrieved 4 April 2017.. ... Butler D (October 2012). "SARS veterans tackle coronavirus". Nature. 490 (7418): 20. doi:10.1038/490020a. PMID 23038444.. ... "Novel coronavirus update-new virus to be called MERS-CoV" (Press release). WHO. 16 May 2013.. ...
WHO: Novel coronavirus infection. 2013-02-11 [2013-02-13].. *^ James Gallagher. Coronavirus: Signs the new Sars-like virus can ... WHO confirms 13th novel coronavirus case. CIDRAP. 2013-02-21.. *^ World Health Organization. Novel coronavirus infection - ... Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group. Journal of Virology. 2013 ... MERS Coronaviruses in Dromedary Camels, Egypt. 06-2014 [08-06-2015].. 请检查. ,access-date=, ,date=. 中的日期值 (帮助) ...
Guy JS (2008). "Isolation and propagation of coronaviruses in embryonated eggs". Methods Mol. Biol. 454: 109-17. doi:10.1007/ ...
Coronavirus as a possible cause of severe acute respiratory syndrome; J. S. M. Peiris u. a. - Der Erreger von SARS ist ... Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome; T. Kuiken u. a. - Bestätigung PMID ...
Wong S. K., Li W., Moore M. J., Choe H., Farzan M. A 193-amino acid fragment of the SARS coronavirus S protein efficiently ... Gralinski, Lisa E.; Menachery, Vineet D. Return of the Coronavirus: 2019-nCoV (неопр.) // Viruses. - 2020. - Т. 12, № 2. - С. ... Letko, Michael; Munster, Vincent. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, ... in SARS coronavirus-induced lung injury (англ.) // Nature Medicine : journal. - 2005. - August (vol. 11, no. 8). - P. 875-879 ...
a b This nursing home is at the center of Washington's coronavirus. Here's what one first responder saw there CNN ... a b 'Still in triage mode': More residents, employees of Kirkland nursing home are hospitalized with coronavirus symptoms The ... "Washington coronavirus death occurred at facility owned by Cleveland, Tennessee-based Life Care Centers". timesfreepress.com. 2 ... Cases of the coronavirus, including a death, have been linked to a nursing home belonging to Cleveland, Tennessee-based Life ...
Middle East respiratory syndrome coronavirus has been found to bind to DPP4. DPP4 is found on the surface of cells in the ... "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC". Nature. ScienceNews. 495 (7440): 251-4 ...
Transmissible gastroenteritis coronavirus (TGEV) occurs in pigs resulting in vomiting, diarrhea, and dehydration.[88] It is ...
"Boris Johnson and Matt Hancock in self-isolation with coronavirus". The Guardian. 2020-03-27. Retrieved 2020-03-27.. ... "PM Boris Johnson tests positive for coronavirus". BBC News. 2020-03-27. Retrieved 2020-03-27.. ...
The Coronavirus causes 10% to 15% of cases. The flu causes 5% to 15% of cases.[3] Other cases may be caused by human ... Coronaviruses are a group of viruses known for causing the common cold. They have a halo, or crown-like (corona) appearance ...
Li W, Shi Z, Yu M, Ren W, et al. Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005 Oct 28;310(5748):676-9. ... and the SARS like coronaviruses[14][15] and in many cases as a vector for various viruses such as the lyssaviruses including ...
"Middle East respiratory syndrome coronavirus (MERS-CoV)". World Health Organization.. *^ (in Chinese). "疑中招韓男隱瞞病歷經港往惠州新沙士殺到". 蘋 ... "Middle East respiratory syndrome coronavirus (MERS-CoV)". World Health Organization.. *^ Jack, A (2015). "Why the panic? South ... An outbreak of Middle East respiratory syndrome coronavirus occurred in South Korea from May 2015 to July 2015.[3] The virus, ... "Middle East respiratory syndrome coronavirus (MERS-CoV) - Republic of Korea". World Health Organization. Retrieved
"Middle East respiratory syndrome coronavirus (MERS-CoV) - China". 31 May 2015.. *^ 8,0 8,1 Hubbarb, Ben; McNeill Jr., Donald G ... "Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian ... "Middle East respiratory syndrome coronavirus (MERS-CoV) - Republic of Korea". www.who.int. 24 May 2015.. ... "Receptor for new coronavirus found". nature.com. 2013-03-13. Pridobljeno dne 2013-03-18.. ...
Her en del af RNA'et i Coronavirus, der fungerer som signalsegment.. Liv er den egenskab som deles af alle organismer. Fysiske ...
Detection of Avian coronavirus infectious bronchitis virus type QX infection in Switzerland ... Infectious bronchitis, a disease of chickens caused by Avian coronavirus infectious bronchitis virus (IBV), leads to severe ... Infectious bronchitis, a disease of chickens caused by Avian coronavirus infectious bronchitis virus (IBV), leads to severe ... Detection of Avian coronavirus infectious bronchitis virus type QX infection in Switzerland. Journal of Veterinary Diagnostic ...
Rat coronavirus (SDAV) Test code: S0143 - Ultrasensitive qualitative detection of rat coronavirus (Sialodacryoadenitis virus or ... Rat coronavirus or Sialodacryoadenitis (SDA) virus is an airborne RNA virus whose primary route of infection is via respiratory ... Rats infected with rat coronavirus begin to show symptoms as early as 5 days, with respiratory involvement and cervical ...
One thought on "Columbia researchers extract live MERS coronavirus from Dromedary camels". * Pingback: Camels vent volumes of ... infectious sample of MERS coronavirus (MERS-CoV) from two camels in Saudi Arabia. The sample matched MERS-CoV found in humans, ...
Animal origins of SARS coronavirus: possible links with the international trade in small carnivores. Philosophical Transactions ...
Perhaps the anxiety pregnant women feel today - in light of the rapid spread of the Coronavirus (Covid-19) around the world - ... Guidelines of Pregnancy during the New Coronavirus Pandemic (Covid-19) ..Prepared by: Dr. Fawaz Amin Saad. ... For more information about pregnancy during the New Coronavirus Pandemic (Covid-19) Read More ... and because it us extremely important to stay at home to protect you from coronavirus infection, Al Hayat Medical Center ...
Get the Facts About Coronavirus. Take steps to care for yourself and help protect others in your home and community. ...
View the spread of COVID-19 on world map.
Guidance for healthcare professionals on Coronavirus (COVID-19) infection in pregnancy, published by the RCOG, Royal College of ... Coronavirus (COVID-19) infection and pregnancy. Published: 13/05/2020 Coronavirus (COVID-19) infection and pregnancy Version 9 ... Coronavirus (COVID-19): latest information and advice on GOV.UK. *Information about the virus and how to protect yourself on ... Read our guidance for provision of midwife-led settings and home birth in the evolving coronavirus (COVID-19) pandemic ...
The European Commission is coordinating a common European response to the coronavirus outbreak. We are taking resolute action ... President von der Leyen has established a Coronavirus response team at political level to coordinate our response to the ... 31 July 2020 - The European Commission concludes talks to secure a future coronavirus vaccine ... 840 million German guarantee scheme to protect consumers and support the travel industry in the context of the coronavirus ...
News and updates about the coronavirus pandemic: Cases in the US, death toll, what you need to know about the virus, how to ... Coronavirus Live updates U.S. map World map Reopening tracker Lives lost Your life at home Your money ... From coronavirus protocols to the playoff format, heres what you need to know about the leagues plans to come back next month ... Get our Coronavirus Updates newsletter. Receive the most important developments every day. All stories linked in the newsletter ...
The coronavirus pandemic has brought countries to a standstill. In many places, as countries reopen, Covid-19 cases are on the ... Bolivia surpasses 72,000 coronavirus cases as government declares state of public calamity. A health worker wearing a face ... July 28 coronavirus news. By Nectar Gan, Adam Renton, Ed Upright, Melissa Macaya, Meg Wagner and Mike Hayes, CNN ... President Trump said some US states should loosen coronavirus restrictions, even as medical experts urge the country to shut ...
Ecuador coronavirus deaths increase. From CNNs Taylor Barnes. The number of coronavirus deaths in Ecuador doubled between ... March 22 coronavirus news. By Julia Hollingsworth, Jenni Marsh, Rob Picheta, Fernando Alfonso III and Amir Vera, CNN ... The global outlook: More than 335,000 people have contracted the novel coronavirus and at least 14,641 have died, according to ... The government of Italy has made a direct appeal to Defense Secretary Mark Esper for US military aid in combating coronavirus, ...
Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child ... Public Health Agency of Canada "Human Coronavirus" Retrieved on July 22, 2015. Center for Disease Control "About Coronavirus" ... Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad ... Most people will be infected with a coronavirus in their lifetime, but some populations are more susceptible to HCoV-NL63. ...
... , March 30: A look at the latest updates on COVID-19 By Joe Nguyen ... Coronavirus in Colorado, March 29: A look at the latest updates on COVID-19 By Joe Nguyen ... Denver family gives their grandpa hugs and kisses through the window of his memory care facility amid coronavirus pandemic By ... Fake police in Greeley direct driver into roadblock, question her about coronavirus stay-at-home order By Shelly Bradbury ...
The latest general information on the Coronavirus Disease 2019 (COVID-19) is available on Coronavirus.gov. For GPO specific ...
Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing ... Coronaviruses, first identified in 1968, require the overlap of human life with animals - and this becomes ever more frequent ... The coronavirus has shown how vulnerable and fragile our interconnected world can suddenly become. But the same modern ... What made it even more alarming, says radio presenter Pagani, was that the first person to have coronavirus was "a real sporty ...
This document and the FAQs are intended to provide you with general information about the 2019 novel coronavirus, including how ... What is coronavirus?. Coronavirus is a new respiratory virus that originated in Wuhan, China. The virus is contagious and ... How is coronavirus spread? Health authorities have not confirmed how coronavirus is transmitted but suspect it is spread person ... How many people survive coronavirus?. Currently, coronavirus has a fatality rate of less than 3 percent. As such, the majority ...
The coronavirus pandemic has brought countries to a standstill. Heres the latest updates on Covid-19 cases, deaths, government ... A White House coronavirus task force source told CNN earlier this week that the Trump Administrations Warp Speed program had ... The coronavirus outbreak in Peru is spiraling out of control and experts fear it will only worsen. ... Coronavirus pandemic: Updates from around the world. By Rob Picheta and Fernando Alfonso III, CNN ...
The novel coronavirus pandemic continues to impact countries worldwide, particularly in Europe and the US. Follow here for live ... At least 917 new US coronavirus deaths reported in single day. There have been at least 917 new coronavirus deaths reported in ... April 1 coronavirus news. By Ben Westcott, Helen Regan, Adam Renton, Tara John, Meg Wagner and Mike Hayes, CNN ... Wyoming remains the only state not reporting a coronavirus death. Wyoming remains the only state in the US without a death from ...
Communicable diseases like coronavirus and the flu can bring a busy workforce to a standstill. Here are ways to prepare your ... Coronavirus and COVID-19 Communicable diseases like coronavirus and the respiratory illness it causes, COVID-19, can bring a ... Need help with a specific HR issue like coronavirus or FLSA? Members can get help with HR questions via phone, chat or email. ... Families First Coronavirus Response Act (FFCRA) mandatory Federal Poster Change, effective April 1 for employers with 500 or ...
Bloomberg Opinion) -- Just as coronavirus infections weaken, European countries lift foreign travel restrictions and people ... Britain didnt do this back when it would have really made a difference with the new coronavirus; its hard to see the utility ... Coronavirus stimulus: Why this Trump adviser argues against a $600 unemployment extension. Yahoo Finance ... We developed our Telehealth product around patients not the coronavirus: Privia Health CEO. Yahoo Finance Video ...
most coronavirus infections will either have no symptoms or mild symptoms consistent with the flu. ... Is this coronavirus or pneumonia?. ANSWER Many people will get infected or sick during this outbreak. Most coronavirus ... More Answers On Coronavirus. *If hand washing isnt available, is hand sanitizer effective to get rid of coronavirus? ... For those that have more severe cases that require hospitalization coronavirus can get worse and one complication is pneumonia ...
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Russias coronavirus cases surpassed 300,000 on Wednesday, cementing its position as the second-worst-hit country from the ... Russias coronavirus cases surpassed 300,000 on Wednesday.. *It has the second-highest number of confirmed coronavirus cases in ... Russia reported a further 8,764 coronavirus cases Wednesday, pushing its total case tally to 308,705, its coronavirus crisis ... Russias coronavirus cases surpassed 300,000 on Wednesday, cementing its position as the second-worst-hit country from the ...
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  • Coronavirus is a new respiratory virus that originated in Wuhan, China. (shrm.org)
  • The new coronavirus was first identified in Wuhan, Hubei Province, China and has caused illnesses throughout China and around the world, including in the United States. (fmi.org)
  • One thing's for sure about the Coronavirus which originated in Wuhan, China: nobody knows how bad it will be for human lives and the global economy. (forbes.com)
  • Since the coronavirus took hold in the United States, senior officials in the Trump administration have amplified rumors that the virus emerged from a virology lab in Wuhan. (forbes.com)
  • Covid-19 or the Wuhan coronavirus as CNN refers to it, also known as the CCP Virus by The Washington Post and The Epoch Times , is a particular potentially deadly strain that first was reported to appear in the city of Wuhan, China in late November and early December 2019. (conservapedia.com)
  • Nine people have died from the flu-like coronavirus in China, with 440 confirmed cases, most in the central city of Wuhan where the virus first appeared late last year. (reuters.com)
  • Even people in the highest ranks of government have parroted unsupported suspicions that the novel coronavirus was either invented in a virus laboratory in Wuhan, China, or allowed to escape from there. (orlandosentinel.com)
  • The coronavirus outbreak in Wuhan-and the subsequent shutdown of many Chinese factories-was having a ripple effect across the global economy all the way down to the carpeting in U.S. buildings. (commondreams.org)
  • How is coronavirus spread? (shrm.org)
  • Health authorities have not confirmed how coronavirus is transmitted but suspect it is spread person-to-person. (shrm.org)
  • By following these important precautions and by planning ahead, we can help contain and prevent the spread of coronavirus. (shrm.org)
  • F ears mounted on Saturday over the rise of new cases and fatalities outside China from the coronavirus outbreak, as the World Health Organization warned of a shrinking window to stem the spread of the deadly disease. (telegraph.co.uk)
  • This virus is a new coronavirus that has spread throughout the world. (medlineplus.gov)
  • While social distancing is imperative to contain the spread of the coronavirus, it can take a serious toll on mental health. (yahoo.com)
  • We are taking precautionary measures to ensure the health and safety of employees, to minimize the impact on the company's operations and to prevent further spread of the coronavirus. (ericsson.com)
  • MILAN-Italy's coronavirus outbreak continued to spread, bucking efforts to contain it mostly to two rural areas near Milan and Venice. (wsj.com)
  • What can be done to prevent the spread of coronavirus? (fmi.org)
  • Coronavirus is a respiratory virus spread through respiratory droplets. (fmi.org)
  • Factories and, in particular, indoor areas which are cold and damp are perfect environments for coronavirus to linger and spread," said Lawrence Young, Professor of Molecular Oncology at the University of Warwick. (reuters.com)
  • Alcohol-based sanitizers are helpful, but thorough hand-washing is the best protection against the spread of the new coronavirus. (chicagotribune.com)
  • 780 million people are facing travel restrictions and 58 million people are in lockdown as Beijing tries to stop the spread of coronavirus. (news.com.au)
  • AP) - Gov. Tony Evers on Thursday ordered the closure of 40 Wisconsin's state parks, forests and recreational areas primarily in southern and southeastern Wisconsin to help reduce overcrowding and vandalism and to slow the spread of the coronavirus. (gazettextra.com)
  • With 2,500 asylum-seekers packed in tightly and no coronavirus tests available, doctors and volunteers are doubtful that education will be enough to prevent the spread of the virus. (foreignpolicy.com)
  • Chinese authorities are employing drones in their fight to contain the new coronavirus outbreak, including using loudspeakers to warn unsuspecting members of the public who are taking insufficient precautions or breaking rules put in place to prevent the spread of the virus, China state television claims. (msn.com)
  • French municipal elections will go ahead on Sunday amid reassurances from the government that all necessary safety precautions are being taken against the spread of the coronavirus. (france24.com)
  • SEOUL- North Korea 's not saying a word about deaths or illnesses from the coronavirus , but the disease reportedly has spread across the border from China and is taking a toll in a country with a dismal health care system and scant resources for fighting off the deadly bug. (thedailybeast.com)
  • Russia reported a further 8,764 coronavirus cases Wednesday, pushing its total case tally to 308,705, its coronavirus crisis center said. (cnbc.com)
  • However, while there does seem to be a decline in new daily cases across the country - Wednesday marked the fifth day in a row that fewer than 10,000 new cases were announced - the coronavirus crisis is still a challenge unlike any faced by President Putin in his two decades in power . (cnbc.com)
  • The coronavirus crisis has expanded access to telehealth and telemedicine," Hanna Horvath, a personal finance and healthcare expert at Policygenius , told FOX Business. (yahoo.com)
  • As coronavirus cases continue to climb in the U.S., another public health crisis is brewing. (cbsnews.com)
  • MADRID (Reuters) - Spain struggled to cope on Wednesday with a mounting coronavirus crisis as its death toll exceeded China's with another 738 lives lost in a single day, and a third senior government minister was diagnosed with the virus. (yahoo.com)
  • A daily update on the coronavirus crisis in Florida. (orlandosentinel.com)
  • But they can cause a range of respiratory symptoms from mild to serious - it was a coronavirus that was responsible for the 2002-2004 outbreak of the severe acute respiratory syndrome (SARS), though the novel coronavirus (until recently known as 2019-nCoV, though now dubbed SARS-CoV-2) has already outstripped the SARS death toll in the three months since it has been active. (ox.ac.uk)
  • With over 17,390 confirmed cases of Novel coronavirus (2019-nCoV) around the world, the virus has so far claimed 362 lives.There are 10 confirmed cases without any death case. (forbes.com)
  • From the latest news to binge-watching suggestions to tips for caring for your mental health, we've got everything you need to know about coronavirus to stay safe and make the most of your time spent at home. (buzzfeed.com)
  • Rebecca Damon, vice president of SAG-AFTRA, confirmed Blum's death: "It is with such deep sorrow that I'm writing to share the news that our friend and former board member Mark Blum has passed away as a result of complications from the coronavirus. (usatoday.com)
  • News of Blum's death follows the announcement Tuesday of the coronavirus-related death of Broadway playwright Terrence McNally . (usatoday.com)
  • The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19 and the coronavirus that causes it. (sciencemag.org)
  • Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center . (medscape.com)
  • Some conspiracy theorists, anti-vaxxers and fake news websites have alleged that the coronavirus was stolen from a Canadian virus research lab by Chinese scientists, citing a news article by the Canadian Broadcasting Corporation in July 2019. (wikipedia.org)
  • A few days after the president slandered Scarborough, Eric Trump - like father, like son - claimed on Fox News that the coronavirus is a Democratic hoax that will disappear "magically" after the November election. (orlandosentinel.com)
  • Answer: they're just some of the Oxford University researchers coming together to fight the novel Coronavirus outbreak which has (to date) killed thousands of people across the globe, with tens of thousands of people infected. (ox.ac.uk)
  • Bolivia's Health Ministry reported 1,146 newly confirmed coronavirus cases for Tuesday, bringing the country's total cases to 72,327. (cnn.com)
  • It has the second-highest number of confirmed coronavirus cases in the world after the U.S. (cnbc.com)
  • Here are the most commonly asked questions typed into Google Search related to coronavirus. (news.com.au)
  • The Strategic National Stockpile is nearly out of the N95 respirators, surgical masks, face, shields, gowns and other medical supplies desperately needed to protect front-line medical workers treating coronavirus patients. (cbsnews.com)
  • If you show symptoms or you have been in contact with someone who has a confirmed case of coronavirus, and you feel sick with fever, cough, or difficulty breathing, you should contact your county health department ( floridahealth.gov/chdepicontact ) or a primary care physician. (chicagotribune.com)
  • Health care providers in Iowa who suspect a case of coronavirus are being told to reach out to the Iowa Department of Public Health Center for Acute Disease Epidemiology. (desmoinesregister.com)
  • There have been more than 6.6 million confirmed cases of the coronavirus worldwide. (washingtonpost.com)
  • More than 1.8 million coronavirus cases have been reported in the United States, including at least 106,000 fatalities. (washingtonpost.com)
  • New South Wales, the state Sydney is located in, reported 19 new coronavirus cases on Wednesday. (cnn.com)
  • For those that have more severe cases that require hospitalization coronavirus can get worse and one complication is pneumonia. (webmd.com)
  • Russia's coronavirus cases surpassed 300,000 on Wednesday. (cnbc.com)
  • Russia's coronavirus cases surpassed 300,000 on Wednesday, cementing its position as the second-worst-hit country from the virus after the U.S., but there are increasing questions over the country's low death toll. (cnbc.com)
  • Disney World reopened its theme parks on Saturday, even as Florida has become a hotspot for coronavirus cases in the country. (buzzfeed.com)
  • Florida has seen a massive surge in coronavirus cases and hospitalizations in recent weeks. (buzzfeed.com)
  • Dr. Bruce Dart said he and his staff were "[connecting] the dots" between the rally and a surge in local coronavirus cases. (buzzfeed.com)
  • The New York Times is tracking all known cases of the coronavirus in the United States. (nytimes.com)
  • Learn how to access the data or download county-level data for coronavirus cases on GitHub . (nytimes.com)
  • A map showing the number of Coronavirus cases in Europe. (yahoo.com)
  • In December 2019, Chinese health authorities identified an outbreak of pneumonia associated with a novel, or new, coronavirus which has resulted in thousands of confirmed cases in China. (tn.gov)
  • currently, there are 60 countries that have seen cases of Coronavirus and your go-to should be an official travel advisory issued by the government body. (indiatimes.com)
  • There are no confirmed cases of coronavirus in Iowa as of Wednesday. (desmoinesregister.com)
  • The latest Chinese government figures, released Tuesday, report that there are 20,438 confirmed cases of the new coronavirus in mainland China and there have been 420 deaths resulting from the virus since the outbreak began in Dec. 2019. (msn.com)
  • The coronavirus is certainly scary, but despite the constant reporting on total cases and a climbing death toll, the reality is that the vast majority of people who come down with COVID-19 survive it. (livescience.com)
  • Specifically, the formation of double membrane vesicles (DMVs), a hallmark of coronavirus replication, was greatly impaired upon K22 treatment accompanied by near-complete inhibition of viral RNA synthesis. (slideshare.net)
  • The effect of Hydrocyn® aqua (Hydrocyn) on the new coronavirus (SARS-CoV-2) causing COVID-19 has been confirmed. (prnewswire.com)
  • New claims that the novel coronavirus SARS-CoV-2 was engineered have been dismissed by scientific and intelligence experts. (forbes.com)
  • The human coronavirus discovered in 2003, SARS-CoV, causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes upper and lower respiratory tract infections. (conservapedia.com)
  • The emergence of the highly pathogenic SARS coronavirus (SARS-CoV) has reignited interest in coronavirus biology and pathogenesis. (nih.gov)
  • Aware that the coronavirus (also called SARS-CoV-2) is shed in feces, Wiedenheft and his fellow researchers decided to collect wastewater samples from the Bozeman municipal wastewater treatment plant, which serves the city's roughly 48,000 residents. (medscape.com)
  • Mississippi's governor declared a state of emergency to help fight coronavirus in the state and said he will work from home for two weeks after returning Friday from a family trip to Spain. (sfgate.com)
  • Should You Clean Your Phone to Combat Coronavirus? (wsj.com)
  • Most people will be infected with a coronavirus in their lifetime, but some populations are more susceptible to HCoV-NL63. (wikipedia.org)
  • How many people survive coronavirus? (shrm.org)
  • It's now encouraging people to wear them to prevent the coronavirus from spreading. (cnn.com)
  • Bloomberg Opinion) -- Just as coronavirus infections weaken, European countries lift foreign travel restrictions and people gear up for the possibility that we might actually get on an airplane again, one of the world's largest tourism markets is effectively shutting down. (yahoo.com)
  • The coronavirus can stay aloft for hours in tiny droplets in stagnant air , infecting people as they inhale, mounting scientific evidence suggests. (nytimes.com)
  • It gives 12 weeks of paid leave to people caring for children whose schools are closed or whose child care provider is unavailable because of the coronavirus. (nytimes.com)
  • On Thursday, NHS England confirmed the total number of people with coronavirus in the UK rose to 590. (yahoo.com)
  • We had prepared a plan in recent days, because it was clear what has happened could somehow happen,' Health Minister Speranza said as doctors tested hundreds of people who might have come into contact with the coronavirus sufferers. (telegraph.co.uk)
  • The U.S. health department's civil rights office is opening up investigations to make sure states aren't allowing medical providers to discriminate against people based on disabilities, race, age or other factors when treating them for the coronavirus, according to The New York Times . (livescience.com)
  • In South Korea, more coronavirus patients recovered and were discharged (4,811 people) than were undergoing treatment (around 4,500 people) on Saturday, according to The Washington Post . (livescience.com)
  • More than 14,700 people have died from the new coronavirus in the United States, according to Johns Hopkins University. (cbsnews.com)
  • Across Italy 2.502 people were infected by the novel Coronavirus so far. (cnbc.com)
  • The coronavirus disease (COVID-19) outbreak has swept the world, killing 2,770 people and infecting more than 81,000. (news-medical.net)
  • Coronaviruses are found in different animals such as camels, cattle, cats and bats and some coronaviruses can infect people. (fmi.org)
  • By February 3, the Coronavirus had infected 17,000 people and claimed 360 lives - primarily in mainland China, according to the Wall Street Journal . (forbes.com)
  • The league was left with little choice but to exclude fans for round two after the Australian government advised on Friday that people should not gather in groups of more than 500 from Monday because of the risk of spreading the coronavirus. (rte.ie)
  • About 58 million people in China have been forced into lockdown as residents in the heart of the coronavirus outbreak are told only one family member can leave the house once every three days. (news.com.au)
  • Calling the coronavirus a hoax encourages people to take risks with their own lives and the lives of others. (orlandosentinel.com)
  • Since this coronavirus is so new, scientists still don't know whether people who recover from COVID-19 are immune to future infections of the virus . (livescience.com)
  • For most people, the new coronavirus causes only mild or moderate symptoms, such as fever and cough. (sfgate.com)
  • As it moves around the world, the coronavirus has compromised the circulatory system of globalization, dramatically reducing the international flow of money, goods, and people. (commondreams.org)
  • Mental health non-profit Beyond Blue have reported a direct spike in people reporting negative mental health due to COVID-19, prompting the organisation to launch an all-hours Coronavirus Mental Wellbeing Support Service . (news.com.au)
  • His family announced his death was due to complications from coronavirus. (cbsnews.com)
  • Veteran stage and screen actor Mark Blum has died from complications of coronavirus. (usatoday.com)
  • Most coronavirus infections will either have no symptoms or mild symptoms consistent with the flu. (webmd.com)
  • Coronaviruses affect the upper-respiratory tract, causing infections ranging from mild to severe, such as bronchitis and pneumonia. (conservapedia.com)
  • Scrambling to contain rapidly rising number of new coronavirus infections in Italy, the largest amount outside Asia, authorities on Sunday stepped up measures to ban public gatherings, including stopping Venice's famed carnival events. (france24.com)
  • An April 12 map shows the number of infections and deaths by state from the coronavirus. (orlandosentinel.com)
  • I don't think it's really hit me yet," says Maria Vittoria Falchetti, who works for her family's firm in the northern Italian town of Codogno, in the epicentre of the country's brutal coronavirus epidemic. (bbc.co.uk)
  • Most insurance providers do not offer cover in case of an epidemic, including Coronavirus. (indiatimes.com)
  • BANGKOK, Jan 22 (Reuters) - Thailand has quarantined a fourth patient with the new coronavirus including one Thai national, authorities said on Wednesday, days before the Lunar New Year holiday when thousands of Chinese tourists are expected to arrive. (reuters.com)
  • Fear of the Coronavirus and China's integration has caused repercussions around the world. (forbes.com)
  • The Chinese authorities are pumping significant levels of cash into the financial system in an effort to shield China's economy from the coronavirus outbreak. (telegraph.co.uk)
  • But reports have filtered out about Kim's subjects falling prey to coronavirus despite the country's decision to seal its 880-mile border with China, most of it along the Yalu River into the Yellow Sea to the west, and its 11-mile border with Russia where the Tumen River flows into the Pacific. (thedailybeast.com)
  • President Trump said some US states should loosen coronavirus restrictions, even as medical experts urge the country to shut down . (cnn.com)
  • President Trump harshly criticized the World Health Organization during his daily Coronavirus Task Force briefing Tuesday. (cbsnews.com)
  • Trump botched the coronavirus response. (foreignpolicy.com)
  • President Donald Trump began Wednesday's White House press conference by calling the coronavirus the 'Chinese virus. (hollywoodreporter.com)
  • They initially discovered that K22 had antiviral activity against a relatively harmless coronavirus that causes mild cold-like symptoms in humans. (slideshare.net)
  • Many studies have reported the co-occurrence of HCoV-NL63 with other human coronavirus, influenza A virus, respiratory syncytial virus (RSV), parainfluenza virus, and human metapneumovirus (hMPV). (wikipedia.org)
  • The coronavirus emergency relief package gives many American workers paid leave if they need to take time off because of the virus. (nytimes.com)
  • 1. Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus Anna Lundin1. (slideshare.net)
  • They must have a positive coronavirus test, and the virus has already affected the respiratory tract. (news-medical.net)
  • Meanwhile, the U.S. government has asked Congress for coronavirus funding of $1.25 billion to track fast the development of drugs and vaccines against the virus. (news-medical.net)
  • The 2019 novel coronavirus is a new strain of the virus that has not previously been identified in humans. (fmi.org)
  • Sørensen told Norwegian broadcaster NRK that the virus has properties that differ greatly from SARS, another coronavirus, and have never been detected in nature. (forbes.com)
  • Public health department says Iowa laboratory can now test for coronavirus strain The Coralville-based lab will collect specimens sent by the Iowa Department of Public Health, the state agency overseeing local response to the virus. (desmoinesregister.com)
  • Coronavirus vs. Flu: Which Virus Is Deadlier? (wsj.com)
  • Amid the US coronavirus lockdown, Blizzard has been delivering care packages of essential supplies to homebound staff in California and Texas. (vg247.com)
  • We summarize by identifying future points of consideration that will contribute greatly to our understanding of the molecular mechanisms governing coronavirus pathogenesis and virulence, and the development of severe disease in humans and animals. (nih.gov)
  • Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated K22, that specifically targets membrane-bound coronaviral RNA synthesis. (slideshare.net)
  • Super Rugby has been put on hold in the wake of New Zealand announcing that travellers entering the country must self-isolate for 14 days due to fears over the coronavirus outbreak. (rte.ie)
  • French voters will choose their mayors and regional representatives for the next five years at local elections, the first round of which are due to go ahead on Sunday despite fears of coronavirus contagion. (france24.com)
  • If you have had close contact with someone exhibiting coronavirus symptoms who has recently traveled from China, you should call ahead to a health care professional and mention your close contact and the person's recent travel. (shrm.org)
  • Evacuees from the China coronavirus outbreak toss their masks after finishing quarantine in Riverside, California, February 11. (reuters.com)
  • Chinese President Xi Jinping inspects the coronavirus prevention and control work at Anhuali Community in Beijing, China, February 10. (reuters.com)
  • China and Russia are sending medical aid to Italy and other coronavirus-stricken countries, but their motives aren't so altruistic. (foreignpolicy.com)
  • After blithely ignoring the coronavirus outbreak in China for most of February, markets took a major dive in the final week of the month. (commondreams.org)
  • What you need to know about Virginia's plan to reopen as coronavirus restrictions start to be lifted. (washingtonpost.com)
  • Australians are living under tough coronavirus restrictions and can only leave the house to work, study or shop for food or other essential items - but the one thing they want to know is when it will all end. (news.com.au)
  • Searching for inhibitors of coronaviruses, an international team of scientists led by Edward Trybala, from the University of Gothenburg, Sweden, and Volker Thiel, from the University of Berne, Switzerland, identified a compound called K22. (slideshare.net)
  • Now, the first step in a clinical trial for a drug to treat coronavirus has commenced, thanks to a team of scientists from the University of Nebraska Medical Center in Omaha. (news-medical.net)
  • A local artist in the city of Chennai in southern India has converted a rickshaw into a creation resembling the novel coronavirus using mostly recycled trash. (reuters.com)
  • The state of Iowa can now test for a deadly strain of coronavirus that is rapidly spreading around the world. (desmoinesregister.com)
  • Colorado School of Mines continues to closely monitor the global outbreak of the novel strain of the coronavirus (COVID-19). (mines.edu)
  • The coronavirus has shown how vulnerable and fragile our interconnected world can suddenly become. (bbc.co.uk)
  • The outbreak, which the World Health Organisation has now declared a global health emergency, is caused by a new type of an old foe: coronaviruses are common enough to be one of the causes of the common cold. (ox.ac.uk)
  • The 2019 novel coronavirus is from a family of viruses known as coronaviruses that are common around the world. (fmi.org)
  • In the world of things, the coronavirus has infected the global supply chains that connect manufacturers and consumers. (commondreams.org)
  • Nintendo recently announced that it expects game development to suffer from a "large impact" as a result of the coronavirus. (vg247.com)
  • Is this coronavirus or pneumonia? (webmd.com)