Coronavirus. Medical search

A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.

Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).

A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.

A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.

A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.

A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.

A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.

Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.

A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.

A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.

Virus diseases caused by CORONAVIRIDAE.

A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).

A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.

A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.

A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.

Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).

A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.

A species of CORONAVIRUS causing enteritis in turkeys and pullets.

A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.

A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.

Ribonucleic acid that makes up the genetic material of viruses.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.

Glycoproteins found on the membrane or surface of cells.

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

Proteins found in any species of virus.

The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.

Established cell cultures that have the potential to propagate indefinitely.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)

Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.

Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.

A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.

Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.

A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)

Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.

Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.

INFLAMMATION of the LIVER in animals due to viral infection.

Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.

The temporal sequence of events that have occurred.

Substances elaborated by viruses that have antigenic activity.

Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.

The relationships of groups of organisms as reflected by their genetic makeup.

The functional hereditary units of VIRUSES.

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.

Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.

An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.

A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

The specificity of a virus for infecting a particular type of cell or tissue.

The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.

Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).

Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.

Specific hemagglutinin subtypes encoded by VIRUSES.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

A family in the suborder Feliformia, order CARNIVORA, comprising one genus Nandinia binotata.

A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.

Inflammation of the lung parenchyma that is caused by a viral infection.

Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.

Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.

A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.

Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.

A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.

Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.

Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.

The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

Deoxyribonucleic acid that makes up the genetic material of viruses.

A general term for diseases produced by viruses.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

The interactions between a host and a pathogen, usually resulting in disease.

A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.

Proteins prepared by recombinant DNA technology.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.

The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.

Inflammation of any segment of the SMALL INTESTINE.

Diseases of domestic swine and of the wild boar of the genus Sus.

DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.

Antibodies produced by a single clone of cells.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The species Delphinapterus leucas, in the family Monodontidae, found primarily in the Arctic Ocean and adjoining seas. They are small WHALES lacking a dorsal fin.

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.

A genus of the family CORONAVIRIDAE characterized by enveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. Toroviruses have been found in association with enteric infections in horses (Berne virus), cattle (Breda virus), swine, and humans. Transmission probably takes place via the fecal-oral route.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.

The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.

Viruses whose genetic material is RNA.

Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. (1/471)

Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthesized by in vitro transcription and translation from the replicase gene demonstrated both cis and trans cleavage activities for PLP-1. We have cloned and overexpressed the PLP-1 domain in Escherichia coli by using a T7 RNA polymerase promoter system or as a maltose-binding protein (MBP) fusion protein. With both overexpression systems, the recombinant PLP-1 exhibited trans cleavage activity when incubated with in vitro-synthesized viral polypeptide substrates. Subsequent characterization of the recombinant PLP-1 revealed that in vitro trans cleavage is more efficient at 22 degrees C than at higher temperatures. Using substrates of increasing lengths, we observed efficient cleavage by PLP-1 requires a substrate greater than 69 kDa. In addition, when PLP-1 was expressed as a polypeptide that included additional viral sequences at the carboxyl terminus of the predicted PLP-1 domain, a fivefold increase in proteolytic activity was observed. The data presented here support previous data suggesting that in vitro and in vivo cleavage of the ORF 1a polyprotein by PLP-1 can occur in both in cis and in trans. In contrast to the cleavage activity demonstrated for PLP-1, no in vitro cleavage in cis or in trans could be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion enzyme. (+info)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (2/471)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability. (+info)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (3/471)

Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA. (+info)

Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. (4/471)

We have characterized the hemagglutinin-esterase (HE) of puffinosis virus (PV), a coronavirus closely related to mouse hepatitis virus (MHV). Analysis of the cloned gene revealed approximately 85% sequence identity to HE proteins of MHV and approximately 60% identity to the corresponding esterase of bovine coronavirus. The HE protein exhibited acetylesterase activity with synthetic substrates p-nitrophenyl acetate, alpha-naphthyl acetate, and 4-methylumbelliferyl acetate. In contrast to other viral esterases, no activity was detectable with natural substrates containing 9-O-acetylated sialic acids. Furthermore, PV esterase was unable to remove influenza C virus receptors from human erythrocytes, indicating a substrate specificity different from HEs of influenza C virus and bovine coronavirus. Solid-phase binding assays revealed that purified PV was unable to bind to sialic acid-containing glycoconjugates like bovine submaxillary mucin, mouse alpha1 macroglobulin or bovine brain extract. Because of the close relationship to MHV, possible implications on the substrate specificity of MHV esterases are suggested. (+info)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (5/471)

This is the first report of the production of monoclonal antibodies against elk coronavirus. The nucleoprotein gene of elk coronavirus was amplified by PCR and was cloned and expressed in a prokaryotic expression vector. Recombinant nucleocapsid protein was used to immunize mice for the production of hybridomas. Twelve hybridomas that produced monoclonal antibodies against the nucleocapsid protein of elk coronavirus were selected by an indirect fluorescent-antibody test, an enzyme-linked immunosorbent assay, and a Western blot assay. Ten of the monoclonal antibodies were of the immunoglobulin G1 (IgG1) isotype, one was IgG2a, and one was IgM. All had kappa light chains. By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues. Antinucleoprotein monoclonal antibodies were found to be better at ruminant coronavirus detection than the anti-spike protein monoclonal antibodies. Because nucleoprotein is a more abundant antigen than spike protein in infected cells, this was not an unexpected finding. (+info)

A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . (6/471)

A cysteine proteinase, papain-like proteinase (PL1pro), of the human coronavirus 229E (HCoV) regulates the expression of the replicase polyproteins, pp1a and ppa1ab, by cleavage between Gly111 and Asn112, far upstream of its own catalytic residue Cys1054. In this report, using bioinformatics tools, we predict that, unlike its distant cellular homologues, HCoV PL1pro and its coronaviral relatives have a poorly conserved Zn2+ finger connecting the left and right hand domains of a papain-like fold. Optical emission spectrometry has been used to confirm the presence of Zn2+ in a purified and proteolytically active form of the HCoV PL1pro fused with the Escherichia coli maltose-binding protein. In denaturation/renaturation experiments using the recombinant protein, its activity was shown to be strongly dependent upon Zn2+, which could be partly substituted by Co2+ during renaturation. The reconstituted, Zn2+-containing PL1pro was not sensitive to 1,10-phenanthroline, and the Zn2+-depleted protein was not reactivated by adding Zn2+ after renaturation. Consistent with the proposed essential structural role of Zn2+, PL1pro was selectively inactivated by mutations in the Zn2+ finger, including replacements of any of four conserved Cys residues predicted to co-ordinate Zn2+. The unique domain organization of HCoV PL1pro provides a potential framework for regulatory processes and may be indicative of a nonproteolytic activity of this enzyme. (+info)

Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. (7/471)

The spike (S) glycoprotein of the Miller strain of transmissible gastroenteritis virus (TGEV) was recently cloned and expressed in baculovirus. The recombinant S protein was used as the coating antigen in a competition (blocking) enzyme-linked immunosorbent assay (ELISA) in combination with monoclonal antibodies to the S protein epitope A (conserved on TGEV and porcine respiratory coronavirus [PRCV]) or epitope D (present on TGEV only) to differentiate PRCV- from TGEV-induced antibodies. One set (set A) of 125 serum samples were collected at different times after inoculation of caesarean-derived, colostrum-deprived (n = 52) and conventional young pigs (n = 73) with 1 of the 2 porcine coronaviruses or uninoculated negative controls (TGEV/PRCV/negative = 75/30/20). A second set (set B) of 63 serum samples originated from adult sows inoculated with PRCV and the recombinant TGEV S protein or with mock-protein control and then exposed to virulent TGEV after challenge of their litters. Sera from set A were used to assess the accuracy indicators (sensitivity, specificity, accuracy) of the fixed-cell blocking ELISA, which uses swine testicular cells infected with the M6 strain of TGEV as the antigen source (ELISA 1) and the newly developed ELISA based on the recombinant S protein as antigen (ELISA 2). The sera from set B (adults) were tested for comparison. The plaque reduction virus neutralization test was used as a confirmatory test for the presence of antibodies to TGEV/PRCV in the test sera. The accuracy indicators for both ELISAs suggest that differential diagnosis can be of practical use at least 3 weeks after inoculation by testing the dual (acute/convalescent) samples from each individual in conjunction with another confirmatory (virus neutralization) antibody assay to provide valid and complete differentiation information. Moreover, whereas ELISA 1 had 10-20% false positive results to epitope D for PRCV-infected pigs (set A samples), no false-positive results to epitope D occurred using ELISA 2, indicating its greater specificity. The progression of seroresponses to the TGEV S protein epitopes A or D, as measured by the 2 ELISAs, was similar for both sets (A and B) of samples. Differentiation between TGEV and PRCV antibodies (based on seroresponses to epitope D) was consistently measured after the third week of inoculation. (+info)

Development of an antigen spot test for detection of coronavirus in bovine fecal samples. (8/471)

We have developed a rapid and sensitive microimmunodot blot assay, the antigen spot test (AST), for the detection of bovine coronavirus (BCV) antigen from neonatal calf fecal samples. The AST procedure can be completed in 3.5 h, whereas the previously reported immunodot blot assays require 10 to 12 h. Ninety-six samples can be tested per membrane, and 10 membranes (960 samples) may be processed by a single technologist in 1 working day. The effects of detergents, oxidizing chemicals, chaotropic agents, and enzyme substrates in improving the sensitivity and signal-to-noise ratio of the AST were studied. Finally, the sensitivity and specificity of AST for the detection of BCV antigen were compared to those of a sandwich enzyme-linked immunosorbant assay (ELISA) and a hemagglutination assay (HA). Of 347 field samples tested by all three methods, 94.2% were positive by AST, 91.4% were positive by ELISA, and 86.7% were positive by HA. The sensitivity of the AST was determined to be 100% compared to the results of the ELISA reference method. The specificity of the AST was 67%, which reflects a lower limit of detection of 10(4) viral particles per ml in a 10% fecal suspension. (+info)

Canine coronavirus), Human coronavirus 229E, Human coronavirus NL63, Miniopterus bat coronavirus 1, Miniopterus bat coronavirus ... Bovine Coronavirus, Human coronavirus OC43), Hedgehog coronavirus 1, Human coronavirus HKU1, Middle East respiratory syndrome- ... related coronavirus, Murine coronavirus, Pipistrellus bat coronavirus HKU5, Rousettus bat coronavirus HKU9, Severe acute ... Avian coronavirus, Beluga whale coronavirus SW1 Genus Deltacoronavirus Species: Bulbul coronavirus HKU11, Porcine coronavirus ...

https://en.wikipedia.org/wiki/Coronavirus

Dr ADDIE website focused research about FIP Coronavirus Site général Coronavirus site général Coronavirus Pictures (CS1 French- ... Feline coronavirus (FCoV) is a positive-stranded RNA virus that infects cats worldwide. It is a coronavirus of the species ... "Feline Coronavirus Type II Strains 79-1683 and 79-1146 Originate from a Double Recombination between Feline Coronavirus Type I ... and porcine transmissible gastroenteritis coronavirus (TGEV). It has two different forms: feline enteric coronavirus (FECV) ...

https://en.wikipedia.org/wiki/Feline_coronavirus

"Coronavirus Australia - Apps on Google Play". play.google.com. Retrieved 9 April 2020. "Government launches Coronavirus ... Coronavirus Australia was an app released by the Australian Government designed to allow users to access information about the ... "Coronavirus Australia on the App Store". 12 April 2020. Archived from the original on 12 April 2020. Retrieved 12 April 2020. ... "Coronavirus (COVID-19) self-isolation and test status notification". covid-form.service.gov.au. Retrieved 12 April 2020. "App ...

https://en.wikipedia.org/wiki/Coronavirus_Australia

... taken between 2017 and 2018 and found a novel coronavirus. This coronavirus is a species of Canine coronavirus (CCoV) which was ... Known as canine respiratory coronavirus (CRCoV) and found to be similar to strain OC43 of bovine and human coronaviruses, it ... A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus ... Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species ...

https://en.wikipedia.org/wiki/Canine_coronavirus

The specific name coronavirus refers to the COVID-19 pandemic. The author states that he also named this species in this manner ... Potamophylax coronavirus is a species of caddisfly in the family Limnephilidae. It is endemic to Kosovo. It was named after the ... The river basin habitat of P. coronavirus has been described as a "battlefield between scientists and civil society on one side ... "New species of insect discovered in Kosovo is named after coronavirus , Climate News , Sky News". 2021-12-03. Archived from the ...

https://en.wikipedia.org/wiki/Potamophylax_coronavirus

The ferret coronavirus is a coronavirus which infects ferrets and is a strain of the species Mink coronavirus 1. The first ... There are two types of ferret coronavirus. These are ferret enteric coronavirus and ferret systemic coronavirus. Murray, Jerry ... April 3, 2020.{{cite web}}: CS1 maint: url-status (link) "Ferret coronavirus taxonomy".{{cite web}}: CS1 maint: url-status ( ... Kiupel, Matti; Maes, Roger K. (2010). "Ferret Coronavirus-Associated Diseases". Veterinary Clinics of North America: Exotic ...

https://en.wikipedia.org/wiki/Ferret_coronavirus

... may refer to: List of deaths from the 2019-20 coronavirus pandemic, a list of notable people 2019-20 ... statistics on the numbers of deaths This disambiguation page lists articles associated with the title Coronavirus deaths. If an ...

https://en.wikipedia.org/wiki/Coronavirus_deaths

Coronavirus'; shot during lockdown". The New Indian Express. 26 May 2020. Retrieved 22 June 2021. "'Coronavirus' Trailer: Ram ... Coronavirus is a 2020 Indian Telugu-language thriller drama film about a family exposed to the virus during the COVID-19 ... "IT'S ABOUT ABUSING GOD" - RAM GOPAL VARMA'S CORONAVIRUS SONG!". Behindwoods. 12 June 2020. Retrieved 13 June 2020. v t e v t e ...

https://en.wikipedia.org/wiki/Coronavirus_(film)

Coronavirus Coronavirus diseases Coronavirus 229E Coronavirus OC43 Coronavirus NL63 Bat SARS-like coronavirus WIV1 Bat-borne ... Novel coronavirus (nCoV) is a provisional name given to coronaviruses of medical significance before a permanent name is ... 2020). "The 2019-2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of ... January 2005). "Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with ...

https://en.wikipedia.org/wiki/Novel_coronavirus

Anon, "Helsinki to trial coronavirus breathalyser", Yle, June 29, 2020. News desk, "Finland to trial instant coronavirus ... A coronavirus breathalyzer is a diagnostic medical device enabling the user to test with 90% or greater accuracy the presence ... Anon, "New coronavirus test that is eight times faster can help locate asymptomatic carriers", EurekAlert!, April 20, 2020. ... "We are engaged in innovative cooperation with corporations to solve the coronavirus crisis, and we will help firms to use the ...

https://en.wikipedia.org/wiki/Coronavirus_breathalyzer

... , or RCV, is a strain or subspecies of Murine coronavirus that infects rats. The earliest discovered strains of ... Parker's rat coronavirus, or PRC and most other rat coronavirus strains cause respiratory illness. Both SDAV and PRC can cause ... They cannot be distinguished morphologically from other members of the genus Coronavirus. The rat coronavirus is a single- ... "Coronaviruses (RCV and SDAV)". dora.missouri.edu. Retrieved 2020-06-11. Funk CJ, Manzer R, Miura TA, Groshong SD, Ito Y, ...

https://en.wikipedia.org/wiki/Rat_coronavirus

... are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in ... The first coronavirus disease was discovered in the late 1920s, however, the most recent common ancestor of coronaviruses is ... As of 2021, 45 species are registered as coronaviruses, whilst 11 diseases have been identified, as listed below. Coronaviruses ... "Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination ...

https://en.wikipedia.org/wiki/Coronavirus_diseases

Coronavirus (CoV) Coronaviridae Coronavirus diseases Coronavirus#Outbreaks Chinese virus (disambiguation) This disambiguation ... Chinese coronavirus may refer to: Severe acute respiratory syndrome coronavirus (SARS-CoV), first reported in Foshan, Guangdong ... China; in November 2002 2002-2004 SARS outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first reported in ... page lists articles associated with the title Chinese coronavirus. If an internal link led you here, you may wish to change the ...

https://en.wikipedia.org/wiki/Chinese_coronavirus

... there are also the Lucheng Rn rat coronavirus, China Rattus coronavirus HKU24 and Myodes coronavirus 2JL14, with a large number ... Murine coronavirus is an important pathogen in the laboratory mouse and the laboratory rat. It is the most studied coronavirus ... In contrast, bovine coronavirus, human coronavirus OC43, and others are still sugar receptors, so the spike NTD retains the ... Murine coronavirus is believed to be most closely related to human coronavirus HKU1. These two species, along with ...

https://en.wikipedia.org/wiki/Murine_coronavirus

... , sometimes called Porcine coronavirus HKU15 (PorCoV HKU15) is a virus first discovered in a surveillance ... "Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene ... Wang, L; Zhang, Y; Byrum, B (2014). "Complete Genome Sequence of Porcine Coronavirus HKU15 Strain IN2847 from the United States ... The virus has been referred to as Porcine coronavirus HKU15, Swine deltacoronavirus and Porcine deltacoronavirus. Porcine ...

https://en.wikipedia.org/wiki/Coronavirus_HKU15

... turkey coronavirus, pheasant coronavirus, duck coronavirus, goose coronavirus, pigeon coronavirus) de Wit, J.J. Sjaak; Cook, ... the genus Coronavirus, it was the type species of the group of all known coronaviruses. When two strains of coronavirus IBV ... The strain of avian coronavirus previously known as infectious bronchitis virus (IBV) is the only coronavirus that infects ... The strain of avian coronavirus previously classified as Turkey coronavirus causes gastrointestinal disease in turkeys. IBV is ...

https://en.wikipedia.org/wiki/Avian_coronavirus

... on Netflix Coronavirus, Explained at IMDb v t e (Articles with short description, Short description is ... Coronavirus, Explained is an American documentary limited series produced by Vox. The series, along with The Mind, Explained ... Jarvey, Natalie (April 25, 2020). "Netflix Unpacks Coronavirus Pandemic With New Season of 'Explained'". hollywoodreporter.com ...

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... (BCV or BCoV) is a coronavirus which is a member of the species Betacoronavirus 1. The infecting virus is an ... Fehr, Anthony R.; Perlman, Stanley (2015). "Coronaviruses: An Overview of Their Replication and Pathogenesis". Coronaviruses. ... Bovine Coronavirus, and Human Coronavirus OC43". Journal of Virology. 80 (14): 7270-7274. doi:10.1128/JVI.02675-05. PMC 1489060 ... "Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus ...

https://en.wikipedia.org/wiki/Bovine_coronavirus

... may refer to: SARS-CoV-2 Delta variant, a variant of SARS-CoV-2 virus that causes COVID-19 Deltacoronavirus, ... a grouping of coronavirus species that affects birds and non-human mammals This disambiguation page lists articles associated ... with the title Delta coronavirus. If an internal link led you here, you may wish to change the link to point directly to the ...

https://en.wikipedia.org/wiki/Delta_coronavirus

Coronaviruses are a group of viruses that cause diseases in mammals and birds. Coronavirus may also refer to: Severe acute ... a disease caused by the coronavirus strain SARS-CoV MERS, a disease caused by the coronavirus strain MERS-CoV Upper respiratory ... respiratory syndrome coronavirus 2 (SARS-CoV-2), a strain that emerged in 2019 Coronavirus disease 2019 (COVID-19), the disease ... Look up coronavirus in Wiktionary, the free dictionary. ... which may be caused by several different coronaviruses This ...

https://en.wikipedia.org/wiki/Coronavirus_(disambiguation)

Coronaviruses manipulate the cell cycle of the host cell through various mechanisms. In several coronaviruses, including SARS- ... 2020). "Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States". Emerging ... it is not required for RNA transcription in all coronaviruses. In at least one coronavirus, transmissible gastroenteritis virus ... In many coronaviruses, a population of N protein is localized to the nucleolus, thought to be associated with its effects on ...

https://en.wikipedia.org/wiki/Coronavirus_nucleocapsid_protein

... is a species of coronavirus in the genus Gammacoronavirus. "International Committee on Taxonomy of ...

https://en.wikipedia.org/wiki/Avian_coronavirus_9203

Human coronavirus HKU1 Lee, Paul (2007). Molecular epidemiology of human coronavirus OC43 in Hong Kong (Thesis). The University ... Wikimedia Commons has media related to Human coronavirus OC43. Wikispecies has information related to Human coronavirus OC43. ... "Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus ... The infecting coronavirus is an enveloped, positive-sense, single-stranded RNA virus that enters its host cell by binding to ...

https://en.wikipedia.org/wiki/Human_coronavirus_OC43

Coronavirus 5′ UTR Coronavirus 3′ UTR pseudoknot Coronavirus 3′ stem-loop II-like motif (s2m) Coronavirus frameshifting ... Coronavirus genomes are positive-sense single-stranded RNA molecules with an untranslated region (UTR) at the 3′ end which is ... Even though a nearby pseudoknot structure, which has been observed in other genera of coronaviruses, is present, its functional ... Yang, Dong; Leibowitz, Julian L. (2015-08-03). "The structure and functions of coronavirus genomic 3′ and 5′ ends". Virus ...

https://en.wikipedia.org/wiki/Coronavirus_3′_UTR

In some coronaviruses, including MERS-CoV, E has been reported to be essential. In others, including mouse coronavirus and SARS ... the intracellular compartment that gives rise to the coronavirus viral envelope. Studies in different coronaviruses have ... In most coronaviruses, E and M are sufficient to form virus-like particles, though SARS-CoV has been reported to depend on N as ... The membrane topology of the E protein has been studied in a number of coronaviruses with inconsistent results; the protein's ...

https://en.wikipedia.org/wiki/Coronavirus_envelope_protein

"Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus". J. Virol ... "Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene ... Bulbul coronavirus HKU11 (Bulbul-CoV HKU11) is a positive-sense single-stranded RNA Deltacoronavirus of avian origin found in ... source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and ...

https://en.wikipedia.org/wiki/Bulbul_coronavirus_HKU11

Within coronavirus lineages, as well as across the four major coronavirus subgroups, the S1 region is less well conserved than ... "Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry". Proceedings of ... "Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus ... Coronaviruses use a very diverse range of receptors; SARS-CoV (which causes SARS) and SARS-CoV-2 (which causes COVID-19) both ...

https://en.wikipedia.org/wiki/Coronavirus_spike_protein

Coronavirus 5′ UTR Coronavirus 3′ UTR Coronavirus 3′ UTR pseudoknot Coronavirus 3′ stem-loop II-like motif (s2m) Coronavirus ... Other RNA families identified in the coronavirus include the coronavirus frameshifting stimulation element, the coronavirus 3′ ... The Coronavirus packaging signal is a conserved cis-regulatory element found in Betacoronavirus (part of the Coronavirus ... bovine coronavirus (BCoV), and human coronaviruses like HCoV-HKU1 and HCoV-OC43. Notably, this element is absent from the other ...

https://en.wikipedia.org/wiki/Coronavirus_packaging_signal

... is a species of coronavirus in the genus Betacoronavirus. "International Committee on Taxonomy of ...

https://en.wikipedia.org/wiki/Myodes_coronavirus_2JL14

... may refer to: White House Coronavirus Task Force Inter-Agency Task Force for the Management of Emerging ... to the COVID-19 pandemic in the Philippines This disambiguation page lists articles associated with the title Coronavirus Task ...

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Giving the Coronavirus emergence in Europe,we decided to share some information in easy-to-readabout the virus.The information ... Easy-to-read information about Coronavirus available in many languages. Giving the Coronavirus emergence in Europe, we decided ... Inclusion Europe > Easy-to-read > Easy-to-read information about Coronavirus available in many languages ... Click here for easy-to-read Coronavirus information in over 10 languages. ...

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Small Business Financial Resources During Coronavirus. NFIB has collected useful resources for small business owners including ...

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NHS information about the coronavirus (COVID-19) vaccine, including who can get a vaccine, how to book and how well the vaccine ... The coronavirus (COVID-19) vaccines are safe and effective. They give you the best protection against COVID-19. ...

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Some coronaviruses cause severe illness that can lead ... Coronaviruses are a family of viruses. Infection with these ... Coronavirus - SARS; Coronavirus - 2019-nCoV; Coronavirus - COVID-19; Coronavirus - Severe acute respiratory syndrome; ... Come in contact with a person with a severe coronavirus infection. *Travelled to a place which had an outbreak of a coronavirus ... Coronavirus disease (COVID-19). www.who.int/health-topics/coronavirus#tab=tab_1. Accessed January 21, 2023. ...

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In addition to traditional SBA funding programs, the CARES Act established several new temporary programs to address the COVID-19 outbreak.

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A collection of RAND research on the topic of Coronavirus ... Coronavirus. Featured. COVID-19 is a respiratory illness caused ... Discontinuation of Buprenorphine Treatment for Opioid Use Disorder During the Coronavirus Disease-2019 Pandemic: A Multilevel ... by a novel coronavirus first identified in late 2019. To help inform responses to the ongoing COVID-19 pandemic, RAND experts ...

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Editors note: Find the latest COVID-19 news and guidance in Medscapes Coronavirus Resource Center. ... Cite this: More Medical Conferences Fall to Coronavirus - Medscape - Mar 09, 2020. ...

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The coronavirus pandemic has brought countries to a standstill. Meanwhile, vaccinations have already started in some countries ... Coronavirus vaccine trials have primarily looked at prevention of symptomatic cases of Covid-19. Previously, there has been ... The study also indicates 8.8% of the UK population had been infected with coronavirus by December - but almost twice as many ... The biggest spreaders of coronavirus in the US are adults aged 20 to 49, and efforts to control the spread -- including ...

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Coronavirus (COVID-19). */ */ The Department of Homeland Security (DHS) efforts in preparedness and readiness have facilitated ... Coronavirus Stability Calculator. DHS Science & Technology has developed an online calculator for predicting the decay of the ... A summary of DHS actions to protect the American public from the coronavirus. ...

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Learn more about the new ArcGIS Coronavirus Testing Sites and Recovery Dashboard Solutions. ... Coronavirus Recovery Solutions Available Now. Weeks after the coronavirus (COVID-19) shut down nearly every state and local ... The Coronavirus Recovery Dashboard includes a series of key recovery indicators defined by the White House Coronavirus Task ... Coronavirus recovery metrics and trends can be quickly tabulated with the Coronavirus Recovery Data Management project. Past ...

https://www.esri.com/arcgis-blog/products/arcgis-solutions/state-government/coronavirus-recovery-solutions-available-now/

New coronavirus subvariants make gains as omicron strain BA.5 fades. What this ultimately means for this fall and winter - a ... Coronavirus surges in Europe and Asia could soon come to the United States, injecting chaos into Thanksgiving and Christmas ... As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the ... As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the ...

https://www.adn.com/tag/novel-coronavirus/

T he unprecedented uncertainty amid the coronavirus pandemic has decimated our carefully laid plans and unsettled our minds at equal pace. (chronicle.com)
the second, " Clarifications ," posted originally in its English translation on the humanities blog An und für sich ), Agamben brings his trademark conceptual apparatus to bear on the global response to the coronavirus pandemic. (chronicle.com)
To respond to the devastating health and economic effects of the coronavirus (COVID-19) pandemic, federal policymakers have enacted several bills, which include significant funding for new and existing programs to aid individuals, businesses and governments across the country. (yahoo.com)
The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (yahoo.com)
As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the fore. (adn.com)
In the face of the global coronavirus pandemic, AARP is providing information and resources to help older adults and those caring for them. (aarp.org)
For those of you joining us on the phone, if you'd like to ask a question about the coronavirus pandemic, press *3 on your telephone keypad to be connected with an AARP staff member who will note your name and question and place you in a queue to ask that question live. (aarp.org)
Sign up for our special edition newsletter to get a daily update on the coronavirus pandemic. (nypost.com)
Read The New Yorker's complete news coverage and analysis of the coronavirus pandemic. (newyorker.com)
On Oct. 1, Trump tested positive for the coronavirus, even as he continued to downplay the severity of the pandemic and suggested that the United States is winning the battle against the virus. (washingtonpost.com)
The Design Museum is closing its doors today, following British prime minister Boris Johnson's official advice that citizens should avoid all public gatherings and non-essential travel in light of the coronavirus pandemic. (dezeen.com)
I n March, the US publisher Scholastic was among those listed by Copyright Clearance Center in its learning-at-home resources as one of the companies responding to the educational crisis triggered by the coronavirus COVID-19 pandemic. (publishingperspectives.com)
Hawkish Sen. Tom Cotton issued a menacing statement on Thursday vowing that the United States 'will hold accountable those who inflicted' the coronavirus on the world, seeming to suggest that the Chinese government is behind the pandemic. (commondreams.org)
Restaurants are the riskiest public locations during the coronavirus pandemic, according to a new study . (moneytalksnews.com)
This article examines the meanings of the Coronavirus Pandemic from a perspective which is both socio-political and psychoanalytic. (bvsalud.org)
[ 3 , 4 ] More recently, the devastating pandemic of the novel coronavirus disease 2019 (COVID-19) led to a similar concern about IPA complicating the course of patients with the severe respiratory form of the disease. (medscape.com)
The article presents a psychoanalytic analysis of the notion of vulnerability articulated to the current context of the new coronavirus pandemic. (bvsalud.org)
As methodological approach, the article presents a theoretical-conceptual review of vulnerability and helplessness, inserting them in the context of the new Coronavirus pandemic. (bvsalud.org)
Early in the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic , before coronavirus disease -2019 (COVID-19) vaccines were authorized, surveys began tracking public acceptance of a hypothetical COVID-19 vaccine . (bvsalud.org)
Canada's Ontario to Expand Use of Private Healthcare Providers Canada's most populous province, Ontario, plans to significantly expand its use of private providers to perform public health services, the premier said on Monday, in a bid to deal with backlogs and delays in a healthcare system strained by the coronavirus pandemic. (medscape.com)

Under the Coronavirus Aid, Relief, and Economic Security Act (CARES Act), as originally enacted March 27, 2020, the Employee Retention Credit is a refundable tax credit against certain employment taxes equal to 50% of the qualified wages an eligible employer pays to employees. (irs.gov)
This guidance provides advice to landlords and tenants on the provisions in the Coronavirus Act 2020, and further advice for landlords, tenants and local authorities more broadly about their rights and responsibilities during the COVID-19 outbreak. (www.gov.uk)
[ 5 , 6 ] On February 11, 2020, the Coronavirus Study Group of the International Committee on Taxonomy of Viruses issued a statement announcing an official designation for the novel virus: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
Melissa Benjamin, left, a member of Colorado Care Workers Unite, returns a bottle filled with hand sanitizer to Tomeka Robinson as care workers join with the Service Employees International Union to distribute supplies to deal with the dangers of the new coronavirus Wednesday, April 29, 2020, in Denver. (denverpost.com)

More than 2.98 million Americans filed for unemployment last week, the Labor Department reported on Thursday, as the shutdowns caused by the coronavirus outbreak continued to deepen the worst economic catastrophe since the Great Depression. (foxbusiness.com)
Taiwan has been tackling its coronavirus outbreak despite being frozen out of the World Health Organization (WHO) and continual bullying from China. (foreignpolicy.com)
All this is done with an impressive level of public transparency and engagement, in stark contrast to China's use of draconian and coercive measures and censorship to handle the coronavirus outbreak. (foreignpolicy.com)
President Trump gambled very early and often on the idea that the coronavirus outbreak wouldn't turn out to be nearly as severe as some health officials warned it could get. (washingtonpost.com)
The National Defense Industrial Association is closely monitoring the current novel coronavirus (COVID-19) outbreak situation. (ndia.org)
Elba urged fans to stay home and stay safe amid the uncertainty of the global coronavirus outbreak, with his wife visibly shaken beside him. (usmagazine.com)
In a Feb. 17 appearance on Fox News , Cotton parroted the unfounded claim that coronavirus may have emerged from a biochemical lab in Wuhan, China, the epicenter of the outbreak. (commondreams.org)
Responding to the new coronavirus in the United States, an $8.3 billion bill to fight the COVID-19 outbreak was signed by President Trump. (whas11.com)
Smugness and arrogance and, as a result, an unchecked return to normal life has made Israel vulnerable to a second wave of the coronavirus at a time when our economic batteries are on empty and the country wasn't properly prepared to handle another outbreak. (haaretz.com)
Throughout the day, we will share the latest coverage from Denver Post journalists on the coronavirus outbreak on this page. (denverpost.com)
Also, bear in mind The Denver Post relies on support from its readers to provide this in-depth coverage of the coronavirus outbreak, so please consider buying a subscription if you haven't already. (denverpost.com)
Organizations providing assistance to victims of domestic violence report an increase in cases of physical and verbal abuse since the Stay at Home Order was issued in response to the coronavirus outbreak. (nbclosangeles.com)
Hospital outbreak of Middle East respiratory syndrome coronavirus. (who.int)

The U.S. Food and Drug Administration is issuing warning letters to firms for selling fraudulent products with claims to prevent, treat, mitigate, diagnose or cure coronavirus disease 2019 (COVID-19) . (fda.gov)
it doesn't mean that you have the Coronavirus disease for sure. (inclusion-europe.eu)
to not get the Coronavirus disease. (inclusion-europe.eu)
reports on the coronavirus disease. (democracynow.org)
The Oxford-AstraZeneca Covid-19 vaccine may reduce coronavirus transmission, rather than simply reducing the severity of disease, according to researchers. (cnn.com)
The coronavirus is a virus that causes a contagious disease known as Covid-19. (mediaite.com)
Coronavirus no longer "clinically" exists in Italy, which has seen the deadly disease lose potency , according to a doctor. (nypost.com)
The National Adverting Division has joined in the battle against coronavirus disease claims by advising a company marketing a superfoods blend to take down a video that NAD says crosses the line. (nutraingredients-usa.com)
Illness caused by SARS-CoV-2 was termed COVID-19 by the WHO, the acronym derived from "coronavirus disease 2019. (medscape.com)
At that time, the rapid rise in coronavirus cases - both within the country and among travelers - was so concerning, a joint WHO and European Center for Disease Prevention and Control mission went to Italy to figure out what was going on. (vox.com)
More than 100,000 people worldwide have been infected by the coronavirus, and the COVID-19 disease caused by the virus has killed more than 3,400. (whas11.com)
Invasive pulmonary aspergillosis (IPA) can affect patients with severe coronavirus disease 2019 (COVID-19), but many questions remain open about its very variable incidence across the world, the actual link between the viral infection and the fungal superinfection, the significance of Aspergillus recovery in a respiratory sample, and the management of such cases. (medscape.com)
What is the Actual Prevalence of Coronavirus Disease 2019-associated Pulmonary Aspergillosis? (medscape.com)
Globally, there is still much to learn about the evolving coronavirus disease 2019 (COVID-19) virus , its transmission , prevention, and treatment . (bvsalud.org)
The HIV community and response have much to offer to the coronavirus disease 2019 (COVID-19) preparedness and resiliency. (bvs.br)

Dec 06, 2022 · At least 1 in 313 residents have died from the coronavirus , a total of 2,434 deaths. (yahoo.com)

A woman undergoes a temperature scan at the entrance of the Uffizi Gallery Museum in Florence as Italy eases its coronavirus lockdown. (nypost.com)
The Trump administration is reviewing new proposed guidelines for how states can gradually reopen businesses, schools and churches, while more state governors signaled their plans to move forward with easing of coronavirus lockdown restrictions. (voanews.com)
First Minister Mark Drakeford has said the Welsh Government is prepared to increase fines for those breaking coronavirus lockdown laws. (itv.com)
Amy Harmon and Rich Rojas at The New York Times are writing in their coverage updated this morning (June 8), "None of the plans for how the nation might safely emerge from the coronavirus lockdown involved thousands of Americans standing shoulder to shoulder in the streets of major cities or coughing uncontrollably when the authorities used tear gas to disperse them. (publishingperspectives.com)

Global lockdowns in response to the coronavirus have resulted in economic turmoil and what is expected to be the worst downturn since the Great Depression in the 1930s. (forbes.com)

COVID: Trump, Melania test positive for coronavirus. (commercialappeal.com)

Coronavirus is also called COVID-19. (inclusion-europe.eu)
Non-statutory guidance for landlords, tenants and local authorities in the private and social rented sectors in the context of Coronavirus (COVID-19). (www.gov.uk)
Check up-to-date coronavirus (COVID-19) guidance and information . (www.gov.uk)
The government has published new guidance for people with coronavirus (COVID-19) and their close contacts . (www.gov.uk)
Updated following the extension of Step 3 of the coronavirus (COVID-19) roadmap on Monday 21 June. (www.gov.uk)
Guidance updated to link to new guidance on (COVID-19) Coronavirus restrictions: what you can and cannot do and new mediation guidance. (www.gov.uk)
The coronavirus (COVID-19) vaccines are safe and effective. (www.nhs.uk)
COVID-19 is a respiratory illness caused by a novel coronavirus first identified in late 2019. (rand.org)
Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center . (medscape.com)
After criticism last year for an early rollout, Russia's Sputnik V coronavirus vaccine is 91.6% effective against symptomatic Covid-19, according to interim analysis published Tuesday. (cnn.com)
Amid school re-openings and 6 million confirmed cases of coronavirus in the U.S., new data from the American Academy of Pediatrics shows that instances of COVID-19 related hospitalizations and deaths among children and teens are increasing at a more rapid pace than the general public. (feminist.org)
The Trump Administration is expelling immigrant children citing COVID-19 concerns, despite the children testing negative for the coronavirus before they are put on planes to their home countries. (feminist.org)
DHS Science & Technology has developed an online calculator for predicting the decay of the virus that causes Coronavirus (COVID-19). (dhs.gov)
Weeks after the coronavirus (COVID-19) shut down nearly every state and local government in the United States, many communities have started turning their attention to reopening and recovery efforts. (esri.com)
Millions of people living in the United States are being told to stay at home to help slow the spread of Coronavirus (COVID-19). (cdc.gov)
Airlines are starting to offer travel waivers due to the growing concern over the new coronavirus, COVID-19. (firstcoastnews.com)
Coronavirus (COVID-19) Situation reports are now included in The WHO Africa outbreaks and emergencies bulletin. (who.int)
This map, hereafter referred to as the "EIOS COVID-19 Map", showing some of the most recent news about the novel coronavirus (SARS-CoV-2), cycles through each news item before being refreshed and re-running the cycle. (who.int)

The Coronavirus Recovery Dashboard includes a series of key recovery indicators defined by the White House Coronavirus Task Force and specific metrics identified by the United States National Governors Association (NGA). (esri.com)

The overall number of global coronavirus cases has surpassed 300 million, while the deaths have surged to more than 5.47 million and vaccinations to over 9.33 billion,, according to the Johns Hopkins. (dailynews.lk)

Muller MA , Paweska JT , Leman PA , Drosten C , Grywna K , Kemp A , Coronavirus antibodies in African bat species. (cdc.gov)

The move is intended to both slow the spread of coronavirus and speed up reopening the economy. (uci.edu)
The additional funding "will be instrumental in helping us prepare to slow the spread of coronavirus," said Lt. Gov. Spencer Cox, who is leading a task force dealing with the virus. (whas11.com)

The U.S. death toll from the coronavirus reached 14 on Friday, with one death in California and the rest in Washington state. (whas11.com)

Teen Mom 2' star Kailyn Lowry has revealed she won't vaccinate herself, or her children, against the coronavirus when a vaccine is created. (hollywoodlife.com)
A Harris County doctor was fired and faces a criminal charge after authorities say he stole coronavirus vaccine to benefit his family and friends. (dallasnews.com)

MERS is caused by the MERS-CoV coronavirus. (medlineplus.gov)
coronaviruses similar to MERS- detection of virus in different secretions, detection and CoV have been identified in bats ( 6 ), but epidemiologic survival of virus in the environment, and detection evidence of their role in transmission is lacking. (cdc.gov)
Saudi Arabian researchers have detected genetic fragments of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the air of a barn holding a camel infected with the virus. (eurekalert.org)
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was confirmed today in a traveler to the United States. (cdc.gov)
Interim U.S. Guidance for Monitoring and Movement of Persons with Potential Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Exposure [cited 2018 8 April]. (who.int)
Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity. (who.int)

It is caused by the SARS-CoV coronavirus. (medlineplus.gov)
It is caused by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). (medlineplus.gov)
At this time, there is no specific treatment for coronavirus infection except for SARS-CoV-2. (medlineplus.gov)
For a coronavirus infection not due to SARS-CoV-2, medicines are given only to ease your symptoms. (medlineplus.gov)
The causative agent was acute respiratory infections, 70 HCoV-229E-positive se- identifi ed as a coronavirus (SARS-CoV) ( 2 - 4 ), and related rum specimens and 4 HCoV-NL63-positive serum speci- viruses found in palm civets ( Paguma larvata ), raccoon mens (provided by L. van der Hoek). (cdc.gov)
Woo PC , Lau SK , Wong BH , Chan KH , Hui WT , Kwan GS , False-positive results in a recombinant severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid enzyme-linked immunosorbent assay due to HCoV-OC43 and HCoV-229E rectified by Western blotting with recombinant SARS-CoV spike polypeptide. (cdc.gov)

The extended school closures caused by the coronavirus crisis have upended the nation's after-school programs, leaving most with no children to serve and no schools to operate out of. (edweek.org)
The coronavirus crisis is placing huge demands on American workers. (nutraingredients-usa.com)
Prime Minister Benjamin Netanyahu's handling of the coronavirus crisis continues to be a resounding failure. (haaretz.com)
The coronavirus is a civilian crisis, and the Shin Bet should be left out of it. (haaretz.com)
Perhaps it's now time for Netanyahu to call them and ask what Israel can learn from them about managing the coronavirus crisis. (haaretz.com)

Many people infected by the coronavirus develop symptoms like a fever and dry cough during the incubation period . (harvard.edu)
The Coronavirus Recovery Dashboard solution can be used to tabulate symptoms, cases, and hospital capacity metrics, monitor key recovery trends and performance targets, and communicate progress made to interested stakeholders. (esri.com)
What are coronavirus symptoms? (firstcoastnews.com)
Anyone with symptoms matching coronavirus, including a fever, cough, or shortness of breath, is asked to stay away from public spaces. (whas11.com)
We have two quarantine areas, so we are not denying help to anyone, even if they have coronavirus symptoms," she said. (nbclosangeles.com)

NBC News' Stephanie Ruhle reports from the New York Stock Exchange amid coronavirus fears. (msnbc.com)
Amid the heartbreaking loss of life and economic hardship wrought by the coronavirus, we recognize the need for stories of kindness, hope, courage and humor. (uci.edu)

HOUSTON - Several employees and customers tested positive for the new coronavirus after going to McIntyre's , a bar in the Heights. (khou.com)
Health officials said two people who tested positive for the new coronavirus have died in Florida. (whas11.com)
Its over 3,500 passengers are confined to their cabins as 21 people aboard the huge cruise ship have tested positive for the new coronavirus. (whas11.com)

President Donald Trump and first lady Melania Trump tested positive for the coronavirus, adding Trump to a short list of world leaders who have contracted the virus. (cnbc.com)
President Trump's campaign manager Bill Stepien has tested positive for coronavirus, Trump Campaign Director of Communications Tim Murtaugh confirmed Friday. (cnbc.com)
Kellyanne Conway, former counselor to President Donald Trump, tweeted that she has tested positive for coronavirus. (cnbc.com)
Over the past four months, President Trump has regularly sought to downplay the coronavirus threat with a mix of facts and false statements. (washingtonpost.com)
Fue uno de los principales miembros del grupo de trabajo sobre coronavirus de la Casa Blanca durante el gobierno de Donald Trump. (mcall.com)

Some animal coronaviruses evolve (mutate) and are passed from animals to humans. (medlineplus.gov)
Antigenic cross-reactivity between the nucleocapsid protein of severe acute respiratory syndrome (SARS) coronavirus and polyclonal antisera of antigenic group I animal coronaviruses: implication for SARS diagnosis. (cdc.gov)

Summary of Middle East respiratory syndrome coronavirus transmission pathways. (cdc.gov)

Nearly 90% of coronavirus deaths happened in countries where most of the population was overweight , according to a new study . (uci.edu)

We encourage Marin County residents to report home based testing results to https://coronavirus.marinhhs.org/SelfTestReporting . (marinhhs.org)

Some coronaviruses cause severe illness that can lead to pneumonia, and even death. (medlineplus.gov)
Severe coronavirus infections may require hospitalization and breathing support. (medlineplus.gov)
Rarely, certain severe coronavirus infections may lead to death, especially in older people, children, or people with chronic conditions. (medlineplus.gov)
Asian bats have been identifi ed as potential reservoir tive-bred Rousettus aegyptiacus at the National Institute hosts of coronaviruses associated with severe acute respira- for Communicable Diseases, Sandringham, SA. (cdc.gov)
Lau SK , Woo PC , Li KS , Huang Y , Tsoi HW , Wong BH , Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. (cdc.gov)
Haynes LM , Miao C , Harcourt JL , Montgomery JM , Le MQ , Dryga SA , Recombinant protein-based assays for detection of antibodies to severe acute respiratory syndrome coronavirus spike and nucleocapsid proteins. (cdc.gov)

Worrying about all the news on the new coronavirus and the illness it causes? (harvard.edu)
Get all the latest news on coronavirus and more delivered daily to your inbox. (foxbusiness.com)
Get expert buying tips about Coronavirus News delivered to your inbox. (consumeraffairs.com)
Conway's daughter broke the news that her mother had tested positive for coronavirus on TikTok, complaining about the fact that she had attended the event. (cnbc.com)
This section curates noteworthy coronavirus news, trends and opinions. (uci.edu)

The cold chain storage for coronavirus vaccines "is a really tricky process," Walgreens chief medical officer Dr. Kevin Ban said on Tuesday. (cnn.com)
The impromptu remarks on "60 Minutes" come as officials struggle to secure new funding for coronavirus vaccines, tests and treatments. (adn.com)
Even greater than the official coronavirus toll may be the collateral damage wrought by an overstretched health system: the pregnant women and babies, cancer and HIV patients, and children in need of vaccines who are now less likely to get the health care they need. (vox.com)

Coronavirus variants are dodging antibody treatments. (washingtonpost.com)
Antibody reactivity to coronavirus (CoV) nucleocapsid (N) protein fragments by ELISA. (cdc.gov)

Mild coronavirus infections, such as the common cold, will go away in a few days with rest and self care at home . (medlineplus.gov)
Coronavirus infections may lead to bronchitis or pneumonia. (medlineplus.gov)
The researchers concluded that a small number of public places are responsible for the lion's share of coronavirus infections. (moneytalksnews.com)

As the new coronavirus sweeps across much of the world and cases exceed 160,000, there is one country that seems to have things under control, despite being only 110 miles from China and having experienced its first case on Jan. 21. (foreignpolicy.com)
Florida added 1,707 coronavirus cases Monday to bring the statewide total to 756,727 cases. (orlandosentinel.com)
The latest breakdown of Florida's coronavirus cases can be found here . (orlandosentinel.com)
The Navajo Nation has seen a significant spike in coronavirus cases. (npr.org)
The number of coronavirus cases on the Navajo Nation is multiplying rapidly. (npr.org)
UAE officials earlier confirmed there were no cases of coronavirus in the country, adding it was "in constant touch with the World Health Organization (WHO) to find out latest updates, recommendations and procedures taken in this matter. (arabnews.com)
The major reason for the extreme response: Cases in Italy escalated fast and the coronavirus overwhelmed the country's health system, particularly in the north. (vox.com)
Officials in Minnesota, Kentucky and South Carolina have confirmed possibly the first cases of the new coronavirus in each state. (whas11.com)

coronavirus -dashboard. (yahoo.com)
You can configure the Coronavirus Recovery Dashboard solution to monitor other metrics established for your organization. (esri.com)

According to a new report released on Wednesday, incarcerated people are twice as likely to die from coronavirus in prison than those on the outside. (feminist.org)
We can't have thousands of people coming in who may have this problem, the coronavirus. (washingtonpost.com)
Since it emerged in December 2019, the coronavirus has officially killed over 6m people, though our own estimate suggests the actual toll exceeds 20m. (economist.com)
They joined Georgia, Oklahoma, Alaska and South Carolina in the push to put people back to work and allow residents to get back to some semblance of their pre-coronavirus lives. (voanews.com)
The virus has infected over 40 million people and has killed over 1.1 million worldwide, according to the Johns Hopkins University & Medicine Coronavirus Resource Center . (orlandosentinel.com)
There was a large turnout Monday at the coronavirus pop-up testing site in Forest Park.Testing began at 1 p.m. at this pop-up site, but some people arrived several hours early.Chelle Smith wanted to be one of the first through the process. (wlwt.com)
Italy has imposed unprecedented national restrictions on its 60 million people to control the spread of the coronavirus. (vox.com)
How many people have died from coronavirus? (whas11.com)
Last Wednesday, the Knesset passed temporary legislation enabling the Health Ministry to seek the Shin Bet security service's help in identifying people who had contact with coronavirus patients. (haaretz.com)
The day after the law passed, the ministry began sending messages to tens of thousands of people telling them to quarantine because they were near a confirmed coronavirus patient. (haaretz.com)

When anxiety rises because we're facing a distressing threat like the new coronavirus, we need to focus on what tends to work for us to ease anxiety - that, plus doing a little bit more of some actions and a little bit less of others. (harvard.edu)
The threat of coronavirus will impact the operation of court systems. (taylorwessing.com)

There are many other coronaviruses circulating in animals, but they haven't spread to humans. (medlineplus.gov)
Once a person has been infected by a coronavirus, the infection can spread to a healthy person (person-to-person transmission). (medlineplus.gov)
Human coronaviruses that cause the common cold spread from person-to-person. (medlineplus.gov)
Testing can also be used to characterize the prevalence, spread and contagiousness of coronavirus as public health officials begin recovery and reopening efforts. (esri.com)
For the latest information about how to stop the spread or to learn more about the federal response, visit coronavirus.gov , cdc.gov/coronavirus , and USA.gov/Coronavirus . (usda.gov)
Soldiers take part in a drill organized by the New Taipei City government to prevent the spread of the new coronavirus. (foreignpolicy.com)
Church services resumed in Montana as the state began to ease restrictions meant to stop the spread of the coronavirus. (voanews.com)
Louisiana Governor John Bel Edwards said Monday he would extend his state's stay-at-home orders through May 15 because some areas have not yet shown enough progress in slowing the spread of the coronavirus. (voanews.com)
So when he heard on the radio how often and for how long he was supposed to wash his hands to avoid the spread of the coronavirus, he was overwhelmed. (npr.org)
Because police stations have closed their reception areas in response to the spread of the coronavirus, victims should contact their nearest police department over the phone in case they need a temporary restraining order or an emergency protective order. (nbclosangeles.com)

By Wednesday, Prime Minister Giuseppe Conte added new coronavirus restrictions, ordering most businesses - except grocery stores and pharmacies - closed. (vox.com)

In April, New Orleans health officials realized their drive-through testing strategy for the coronavirus wasn't working. (npr.org)
The New York Times reported federal officials as saying that the Food and Drug Administration (FDA) is expected to grant expanded emergency use authorization to allow children as young as 12 to receive the coronavirus. (arabamericannews.com)
The first known case of the new coronavirus has arrived in Utah, state and local health officials said Friday night. (whas11.com)
On Thursday, the U.S. Department of Labor and Colorado officials announced that more than 30 million Americans and about 380,000 Coloradans had applied for unemployment aid since the coronavirus hit. (denverpost.com)

Polk County, due to nursing-home outbreaks, has the most coronavirus fatalities in the region with 589, followed by 534 in Orange, 347 in Brevard, 307 in Volusia, 235 in Seminole, 218 in Lake, 182 in Osceola, and 80 in Sumter. (orlandosentinel.com)

Italy - the first country in the world to surpass China's coronavirus death toll - was the first European country to lock down in early March. (nypost.com)

Italy and China used lockdowns to slow the coronavirus. (vox.com)

IMSEAR at SEARO: Coronavirus in respiratory infection. (who.int)
Coronavirus in respiratory infection. (who.int)

Many coronaviruses originate in bats, which can infect other animals. (medlineplus.gov)
Li W , Shi Z , Yu M , Ren W , Smith C , Epstein JH , Bats are natural reservoirs of SARS-like coronaviruses. (cdc.gov)
Detection of group 1 coronaviruses in bats in North America. (cdc.gov)

Coronavirus recovery metrics and trends can be quickly tabulated with the Coronavirus Recovery Data Management project. (esri.com)

Fourteen days is the quarantine period health experts recommend because that's the standard quarantine time for other types of coronavirus. (firstcoastnews.com)

The Wuhan coronavirus is a grave challenge to our great nation,' said Cotton, who announced he is temporarily closing his Washington, D.C. office as a precautionary measure. (commondreams.org)

Anatomy6

Organisms35

Diseases23

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes31

Information Science5

Health Care2

Geographicals4

Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. (1/471)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (2/471)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (3/471)

Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. (4/471)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (5/471)

A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . (6/471)

Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. (7/471)

Development of an antigen spot test for detection of coronavirus in bovine fecal samples. (8/471)

Coronavirus

Coronavirus Infections

Coronavirus 229E, Human

Coronavirus, Bovine

Spike Glycoprotein, Coronavirus

SARS Virus

Coronavirus OC43, Human

Coronavirus, Feline

Coronaviridae

Coronavirus, Canine

Severe Acute Respiratory Syndrome

Coronaviridae Infections

Murine hepatitis virus

Transmissible gastroenteritis virus

Infectious bronchitis virus

Coronavirus NL63, Human

Nucleocapsid Proteins

Coronavirus, Rat

Coronavirus, Turkey

Porcine Respiratory Coronavirus

Viral Envelope Proteins

Feline Infectious Peritonitis

Vero Cells

RNA, Viral

Molecular Sequence Data

Gastroenteritis, Transmissible, of Swine

Membrane Glycoproteins

Cercopithecus aethiops

Virus Replication

Genome, Viral

Antibodies, Viral

Receptors, Virus

Viral Proteins

Viverridae

Cell Line

Amino Acid Sequence

RNA Replicase

Respiratory Tract Infections

Base Sequence

Enteritis, Transmissible, of Turkeys

Viral Matrix Proteins

Viral Nonstructural Proteins

Antigens, CD13

Nucleocapsid

Viral Vaccines

Open Reading Frames

Neutralization Tests

Cats

Middle East

Communicable Diseases, Emerging

Defective Viruses

Cysteine Endopeptidases

Virus Internalization

Hepatitis, Viral, Animal

Chiroptera

Chronology as Topic

Antigens, Viral

Dysentery

Phylogeny

Genes, Viral

Virus Assembly

Virion

Central Nervous System Viral Diseases

Polyproteins

Nidovirales

Peptidyl-Dipeptidase A

Saudi Arabia

Swine

Viral Tropism

Virus Attachment

Cat Diseases

Reverse Transcriptase Polymerase Chain Reaction

Viral Structural Proteins

Cattle Diseases

Hemagglutinins, Viral

Cattle

Cytopathogenic Effect, Viral

Protein Structure, Tertiary

Camels

Sequence Analysis, DNA