A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.
A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.
A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.
Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.
A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.
A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.
Virus diseases caused by CORONAVIRIDAE.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.
A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.
A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.
A species of CORONAVIRUS causing enteritis in turkeys and pullets.
A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Ribonucleic acid that makes up the genetic material of viruses.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.
Glycoproteins found on the membrane or surface of cells.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Proteins found in any species of virus.
The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.
Established cell cultures that have the potential to propagate indefinitely.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
INFLAMMATION of the LIVER in animals due to viral infection.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
The temporal sequence of events that have occurred.
Substances elaborated by viruses that have antigenic activity.
Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.
The relationships of groups of organisms as reflected by their genetic makeup.
The functional hereditary units of VIRUSES.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The specificity of a virus for infecting a particular type of cell or tissue.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
Specific hemagglutinin subtypes encoded by VIRUSES.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A family in the suborder Feliformia, order CARNIVORA, comprising one genus Nandinia binotata.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Inflammation of the lung parenchyma that is caused by a viral infection.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A general term for diseases produced by viruses.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The interactions between a host and a pathogen, usually resulting in disease.
A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
Proteins prepared by recombinant DNA technology.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Inflammation of any segment of the SMALL INTESTINE.
Diseases of domestic swine and of the wild boar of the genus Sus.
DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.
Antibodies produced by a single clone of cells.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The species Delphinapterus leucas, in the family Monodontidae, found primarily in the Arctic Ocean and adjoining seas. They are small WHALES lacking a dorsal fin.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC
A genus of the family CORONAVIRIDAE characterized by enveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. Toroviruses have been found in association with enteric infections in horses (Berne virus), cattle (Breda virus), swine, and humans. Transmission probably takes place via the fecal-oral route.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.
Viruses whose genetic material is RNA.

Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. (1/471)

Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthesized by in vitro transcription and translation from the replicase gene demonstrated both cis and trans cleavage activities for PLP-1. We have cloned and overexpressed the PLP-1 domain in Escherichia coli by using a T7 RNA polymerase promoter system or as a maltose-binding protein (MBP) fusion protein. With both overexpression systems, the recombinant PLP-1 exhibited trans cleavage activity when incubated with in vitro-synthesized viral polypeptide substrates. Subsequent characterization of the recombinant PLP-1 revealed that in vitro trans cleavage is more efficient at 22 degrees C than at higher temperatures. Using substrates of increasing lengths, we observed efficient cleavage by PLP-1 requires a substrate greater than 69 kDa. In addition, when PLP-1 was expressed as a polypeptide that included additional viral sequences at the carboxyl terminus of the predicted PLP-1 domain, a fivefold increase in proteolytic activity was observed. The data presented here support previous data suggesting that in vitro and in vivo cleavage of the ORF 1a polyprotein by PLP-1 can occur in both in cis and in trans. In contrast to the cleavage activity demonstrated for PLP-1, no in vitro cleavage in cis or in trans could be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion enzyme.  (+info)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (2/471)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability.  (+info)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (3/471)

Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA.  (+info)

Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. (4/471)

We have characterized the hemagglutinin-esterase (HE) of puffinosis virus (PV), a coronavirus closely related to mouse hepatitis virus (MHV). Analysis of the cloned gene revealed approximately 85% sequence identity to HE proteins of MHV and approximately 60% identity to the corresponding esterase of bovine coronavirus. The HE protein exhibited acetylesterase activity with synthetic substrates p-nitrophenyl acetate, alpha-naphthyl acetate, and 4-methylumbelliferyl acetate. In contrast to other viral esterases, no activity was detectable with natural substrates containing 9-O-acetylated sialic acids. Furthermore, PV esterase was unable to remove influenza C virus receptors from human erythrocytes, indicating a substrate specificity different from HEs of influenza C virus and bovine coronavirus. Solid-phase binding assays revealed that purified PV was unable to bind to sialic acid-containing glycoconjugates like bovine submaxillary mucin, mouse alpha1 macroglobulin or bovine brain extract. Because of the close relationship to MHV, possible implications on the substrate specificity of MHV esterases are suggested.  (+info)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (5/471)

This is the first report of the production of monoclonal antibodies against elk coronavirus. The nucleoprotein gene of elk coronavirus was amplified by PCR and was cloned and expressed in a prokaryotic expression vector. Recombinant nucleocapsid protein was used to immunize mice for the production of hybridomas. Twelve hybridomas that produced monoclonal antibodies against the nucleocapsid protein of elk coronavirus were selected by an indirect fluorescent-antibody test, an enzyme-linked immunosorbent assay, and a Western blot assay. Ten of the monoclonal antibodies were of the immunoglobulin G1 (IgG1) isotype, one was IgG2a, and one was IgM. All had kappa light chains. By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues. Antinucleoprotein monoclonal antibodies were found to be better at ruminant coronavirus detection than the anti-spike protein monoclonal antibodies. Because nucleoprotein is a more abundant antigen than spike protein in infected cells, this was not an unexpected finding.  (+info)

A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . (6/471)

A cysteine proteinase, papain-like proteinase (PL1pro), of the human coronavirus 229E (HCoV) regulates the expression of the replicase polyproteins, pp1a and ppa1ab, by cleavage between Gly111 and Asn112, far upstream of its own catalytic residue Cys1054. In this report, using bioinformatics tools, we predict that, unlike its distant cellular homologues, HCoV PL1pro and its coronaviral relatives have a poorly conserved Zn2+ finger connecting the left and right hand domains of a papain-like fold. Optical emission spectrometry has been used to confirm the presence of Zn2+ in a purified and proteolytically active form of the HCoV PL1pro fused with the Escherichia coli maltose-binding protein. In denaturation/renaturation experiments using the recombinant protein, its activity was shown to be strongly dependent upon Zn2+, which could be partly substituted by Co2+ during renaturation. The reconstituted, Zn2+-containing PL1pro was not sensitive to 1,10-phenanthroline, and the Zn2+-depleted protein was not reactivated by adding Zn2+ after renaturation. Consistent with the proposed essential structural role of Zn2+, PL1pro was selectively inactivated by mutations in the Zn2+ finger, including replacements of any of four conserved Cys residues predicted to co-ordinate Zn2+. The unique domain organization of HCoV PL1pro provides a potential framework for regulatory processes and may be indicative of a nonproteolytic activity of this enzyme.  (+info)

Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. (7/471)

The spike (S) glycoprotein of the Miller strain of transmissible gastroenteritis virus (TGEV) was recently cloned and expressed in baculovirus. The recombinant S protein was used as the coating antigen in a competition (blocking) enzyme-linked immunosorbent assay (ELISA) in combination with monoclonal antibodies to the S protein epitope A (conserved on TGEV and porcine respiratory coronavirus [PRCV]) or epitope D (present on TGEV only) to differentiate PRCV- from TGEV-induced antibodies. One set (set A) of 125 serum samples were collected at different times after inoculation of caesarean-derived, colostrum-deprived (n = 52) and conventional young pigs (n = 73) with 1 of the 2 porcine coronaviruses or uninoculated negative controls (TGEV/PRCV/negative = 75/30/20). A second set (set B) of 63 serum samples originated from adult sows inoculated with PRCV and the recombinant TGEV S protein or with mock-protein control and then exposed to virulent TGEV after challenge of their litters. Sera from set A were used to assess the accuracy indicators (sensitivity, specificity, accuracy) of the fixed-cell blocking ELISA, which uses swine testicular cells infected with the M6 strain of TGEV as the antigen source (ELISA 1) and the newly developed ELISA based on the recombinant S protein as antigen (ELISA 2). The sera from set B (adults) were tested for comparison. The plaque reduction virus neutralization test was used as a confirmatory test for the presence of antibodies to TGEV/PRCV in the test sera. The accuracy indicators for both ELISAs suggest that differential diagnosis can be of practical use at least 3 weeks after inoculation by testing the dual (acute/convalescent) samples from each individual in conjunction with another confirmatory (virus neutralization) antibody assay to provide valid and complete differentiation information. Moreover, whereas ELISA 1 had 10-20% false positive results to epitope D for PRCV-infected pigs (set A samples), no false-positive results to epitope D occurred using ELISA 2, indicating its greater specificity. The progression of seroresponses to the TGEV S protein epitopes A or D, as measured by the 2 ELISAs, was similar for both sets (A and B) of samples. Differentiation between TGEV and PRCV antibodies (based on seroresponses to epitope D) was consistently measured after the third week of inoculation.  (+info)

Development of an antigen spot test for detection of coronavirus in bovine fecal samples. (8/471)

We have developed a rapid and sensitive microimmunodot blot assay, the antigen spot test (AST), for the detection of bovine coronavirus (BCV) antigen from neonatal calf fecal samples. The AST procedure can be completed in 3.5 h, whereas the previously reported immunodot blot assays require 10 to 12 h. Ninety-six samples can be tested per membrane, and 10 membranes (960 samples) may be processed by a single technologist in 1 working day. The effects of detergents, oxidizing chemicals, chaotropic agents, and enzyme substrates in improving the sensitivity and signal-to-noise ratio of the AST were studied. Finally, the sensitivity and specificity of AST for the detection of BCV antigen were compared to those of a sandwich enzyme-linked immunosorbant assay (ELISA) and a hemagglutination assay (HA). Of 347 field samples tested by all three methods, 94.2% were positive by AST, 91.4% were positive by ELISA, and 86.7% were positive by HA. The sensitivity of the AST was determined to be 100% compared to the results of the ELISA reference method. The specificity of the AST was 67%, which reflects a lower limit of detection of 10(4) viral particles per ml in a 10% fecal suspension.  (+info)

Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
Author affiliations: King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia (B.M. Alraddadi, H.S. Al-Salmi, H.H. Al-Turkistani, S.S. Al-Rehily, H.A. Alserehi, G.Y. Wali, A.N. Alshukairi); Ministry of Health, Jeddah (B.M. Alraddadi, E.I. Azhar, T.A. Madani); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Jacobs-Slifka, R.B. Slayton, C.F. Estivariz, A.I. Geller, L. Haynes, D.L. Swerdlow, J.A. Jernigan); King Abdulaziz University, Jeddah (E.I. Azhar, T.A. Madani) ...
Background: Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV. Methods: We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016. Results: Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one Plasmodium falciparum malaria. Microbiological analysis identified Rhinovirus (27
Detection of human cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection internationally is a global public health concern. Rigorous risk assessment is particularly challenging in a context where surveillance may be subject to under-ascertainment and a selection bias towards more severe cases. We would like to assess whether the virus is capable of causing widespread human epidemics, and whether self-sustaining transmission is already under way. Here we review possible transmission scenarios for MERS-CoV and their implications for risk assessment and control. We discuss how existing data, future investigations and analyses may help in reducing uncertainty and refining the public health risk assessment and present analytical approaches that allow robust assessment of epidemiological characteristics, even from partial and biased surveillance data. Finally, we urge that adequate data be collected on future cases to permit rigorous assessment of the transmission characteristics and
Between 12 and 16 October 2014, the National IHR Focal Point for the Kingdom of Saudi Arabia (KSA) notified WHO of 5 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths.
In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...
Between 13 and 14 March 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. One of these reported cases is linked to the MERS-CoV outbreak currently occurring in a hospital in Buraidah city.
Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to occur. In this study, we present two nucleic acid visualization assays that target the MERS-CoV UpE and N genes as a p
Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic ...
Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…
During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV) was isolated from the sputum of a patient with acute pneumonia and renal failure (1, 2). The isolate was provisionally called human coronavirus Erasmus Medical Center (EMC) (3). Shortly thereafter, in September 2012, the same type of virus, named human coronavirus England 1, was recovered from a patient with severe respiratory illness who had been transferred from the Gulf region of the Middle East to London, United Kingdom (4) (GenBank accession no. KC164505.2). The onset of the new disease was traced back to an even earlier time point. Already in April 2012, a cluster of pneumonia cases in health care workers had occurred in an intensive care unit of a hospital in Zarqa, Jordan (5). Two persons died, both of whom were confirmed to have been infected with the novel coronavirus through a retrospective analysis of stored samples (6). These findings met with considerable concern. Although the number of ...
Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory disease and systemic dysfunction that may eventually lead to the death of the patients. After MERS-CoV was first diagnosed in the South Korea, in May 2015, it affected 186 individuals and claimed 37 lives in short span of time (case fatality rate = 19.9%). Compared to MERS-CoV in the Middle East, MERS-CoV in South Korea appeared to be more transmissible, and induced multiple human-to-human transmission. These knowledge gaps caused the failure of early prevention, and disseminated MERS-CoV brought out a great loss of lives and economy. The MERS-CoV outbreak revealed the potential weakness of public health system in South Korea, and promoted the reestablishment of preventive strategies for imported infectious diseases. In these regards, we analyzed the potential for additional import of re-emerged and emerging infectious diseases, such as dengue fever, malaria, chikungunya fever and hepatitis A, from Africa ...
Clinicians, laboratories and public health practitioners should be aware that many Muslims from Australia will travel to Saudi Arabia in October to undertake the Hajj between 13 and 18 October, and may travel at other times to undertake the Umrah. Health professionals should be aware of the possibility of cases in travellers returning from the Hajj which ends on 18 October 2013.. The Saudi Ministry of Health recommends that elderly people and those with chronic diseases such as heart disease, kidney disease, respiratory disease and diabetes, as well as patients with congenital and acquired immune deficiency diseases, cancer patients, pregnant women and children, defer travel to Saudi Arabia for the Umrah and Hajj this year.. WHO advises that that pre-existing major medical conditions (e.g. chronic diseases such as diabetes or chronic bronchitis, immunodeficiency) can increase the likelihood of medical problems, including MERS-CoV infection, during travel; thus, pilgrims should consult their ...
TY - JOUR. T1 - Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. AU - Josset, Laurence. AU - Menachery, Vineet D.. AU - Gralinski, Lisa E.. AU - Agnihothram, Sudhakar. AU - Sova, Pavel. AU - Carter, Victoria S.. AU - Yount, Boyd L.. AU - Graham, Rachel L.. AU - Baric, Ralph S.. AU - Katzea, Michael G.. PY - 2013. Y1 - 2013. N2 - A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused by SARS coronavirus (SARS-CoV). Although derived from the CoV family, the two viruses are genetically distinct and do not use the same receptor. Here, we investigated whether HCoV-EMC and SARS-CoV induce similar or distinct host responses after infection of a human lung epithelial cell line. HCoV-EMC was able to replicate as efficiently as SARS-CoV in Calu-3 cells and similarly induced minimal ...
On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.
Rapid-response platforms are needed to control newly emerging virus pathogens. MERS-CoV likely emerged in the Middle East from exotic animals, perhaps bats, although the exact timing and origins of this pathogen in human populations remains unclear and is under study. MERS-CoV has caused 54 deaths at the time of writing (∼50% mortality), including documented instances of human-to-human transmission (3, 8). Therefore, the epidemic potential of MERS-CoV is high and its biology, life cycle, gene function, and pathogenic mechanisms clearly warrant additional study.. Developing full-length infectious cDNAs of emerging RNA viruses is assisted by the availability of high-throughput sequencing, gene synthesis, and the use of class II/IIS restriction endonucleases that allow seamless assembly of consensus synthetic cDNA fragments into full-length infectious cDNAs. In this instance, we synthesized a molecular clone from the published sequence, assembled full-length genomes, and isolated recombinant ...
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the
What are coronaviruses?. Coronaviruses are a large family of viruses that can infect humans or animals. Sometimes an animal coronavirus can change so that it can infect people and become a human coronavirus. There are seven known types of human coronaviruses. Four types (229E, NL63, OC43, and KHU1) are common and cause mild to moderate respiratory infections, like the common cold. Two types, Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV), can cause severe respiratory infections. The seventh type (SARS-CoV-2) is the newest coronavirus. It first emerged in the Wuhan Province in China in December 2019. The infectious respiratory disease caused by this virus was named Coronavirus Disease 2019, or more commonly COVID-19.. Who gets coronavirus infections?. Most people become infected with coronaviruses that cause the common cold at some point during their lives. These infections often occur in the fall or winter.. The initial ...
WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR Focal Point (NFP) of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 year-old...
WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...
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Discussion. The novel coronavirus is a member of the β coronavirus type, with humans as the host. Since the first human coronavirus (HCoV) was isolated from the nasal secretions of patients with the common cold in 1965, six different strains of CoV are known to infect humans. These CoV strains include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the common cold viruses in individuals with strong immunity (such as 229E, OC43, NL63, and HKU1).1 This novel coronavirus, COVID-19, has more than 85% homology with the previously detected bat coronavirus (a SARS-related coronavirus species, that is, SARS coronavirus). However, there are clear differences in the genetic characteristics of COVID-19 compared with SARS-CoV and MERS-CoV.5. Through observation of the current global epidemic situation, we can demonstrate the infectivity and pathogenicity of COVID-19. To the treatment of COVID-19, the main treatment is antiviral therapy, ...
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Viral respiratory system diseases such as for example severe acute respiratory system symptoms (SARS) and Middle East respiratory system symptoms (MERS) always pose a serious threat to the people. using the same sea food market. Together with the Spring Event exodus, an outbreak appeared unavoidable. This problem attracted the interest of the Chinese language Middle for Disease Control and Avoidance (CDC), who instantly released a crisis response. The World Health Organization (WHO) also responded promptly and declared the outbreak a public health emergency of international concern (PHEIC). The causative agent of the unidentified pneumonia has been confirmed as a novel coronavirus by sequencing and aetiological investigations by several independent laboratories in China. Following the isolation of the new coronavirus, it was found to be distinct both from Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) [1,2]. Coronaviruses are ...
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV. We also determined high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody. The structures reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they define four conformational states of the trimer wherein each receptor-binding domain is either ...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Background Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS) outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods. Methods The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods. Results The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of
1. Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N. Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis. BMC Public Health. 2016 Nov 29;16(1):1203.. 2. Dinh L, Chowell G, Mizumoto K, Nishiura H. Estimating the subcritical transmissibility of the Zika outbreak in the State of Florida, USA, 2016. Theor Biol Med Model. 2016 Nov 9;13(1):20.. 3. Nah K, Otsuki S, Chowell G, Nishiura H. Predicting the international spread of Middle East respiratory syndrome (MERS). BMC Infect Dis. 2016 Jul 22;16:356. doi: 10.1186/s12879-016-1675-z.. 4. Otsuki S, Nishiura H. Reduced Risk of Importing Ebola Virus Disease because of Travel Restrictions in 2014: A Retrospective Epidemiological Modeling Study. PLoS One. 2016 Sep 22;11(9):e0163418. doi: 10.1371/journal.pone.0163418.. 5. Nishiura H, Mizumoto K, Rock KS, Yasuda Y, Kinoshita R, Miyamatsu Y. A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection. ...
A collaborative team from The University of Texas Medical Branch at Galveston, Saudi Arabia and Canada developed a potent and safe vaccine that protects against the deadly Middle East respiratory syndrome, or MERS.
Comments, concepts and statistics about Healthcare worker infected with Middle East respiratory syndrome during cardiopulmonary resuscitation in Korea, 2015.
Background Viral load kinetics and duration of viral shedding are important determinants for disease transmission. We aimed to characterise viral load dynamics, duration of viral RNA shedding, and viable virus shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids, and to compare SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) viral dynamics. Methods In this systematic review and meta-analysis, we searched databases, including MEDLINE, Embase, Europe PubMed Central, medRxiv, and bioRxiv, and the grey literature, for research articles published between Jan 1, 2003, and June 6, 2020. We included case series (with five or more participants), cohort studies, and randomised controlled trials that reported SARS-CoV-2, SARS-CoV, or MERS-CoV infection, and reported viral load kinetics, duration of viral shedding, or viable virus. Two authors independently extracted data from published studies, or contacted authors to request ...
The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...
Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its family tree.. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...
MERS is caused by a virus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which belongs to the Coronavirus family of viruses. MERS Virus belongs to the genus Betacoronavirus. Coronavirus family of viruses includes viruses that usually cause respiratory tract illnesses like the common cold in human beings, and also, these viruses cause a number of diseases in animals. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) causes Severe Acute Respiratory Syndrome (SARS).. Continue reading → ...
The global novel coronavirus (COVID‐19 or 2019‐CoV) issue has posed significant threats to international human health and the economy, human are fighting this novel coronavirus together. Omega-3 polyunsaturated fatty acids and antiviral treatments should be useful in fighting novel coronavirus (COVID‐19).
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with …
Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein-receptor interacting residues. In conclusion, we suggest that a
Acknowledgment: The authors thank the members of the Department of Clinical Nursing and the Infection Prevention and Control Program, King Abdulaziz Medical City, Riyadh, Saudi Arabia, for their assistance. They also thank the following persons: From the King Saud bin Abdulaziz University for Health Sciences, Riyadh: Sameera Johani, MD, Division of Microbiology, Pathology & Laboratory Medicine; Abdullah Ghamdi, MD, Department of Cardiac Sciences; Ghassan A. Al-Ghamdi, MD, Intensive Care Department and Assistant Professor, College of Medicine; Saqib I. Dara, MD, Intensive Care Department; Raed A. Hijazi, MD, Emergency Medicine; Olivia A. Trinidad, RRT, Edgardo Tabhan, RRT, and Charina Olay, RRT, all Respiratory Therapist I, Respiratory Services. From the King Abdulaziz Hospital, Al-Ahsa: Yusri Taha, MD, and Mohammed Ayman El Gammal, MD, Infectious Diseases, Department of Medicine and Abdulsalam Al-Aithan, MD, Pulmonary & Intensive Care Medicine. From the Imam Abdulrahman Bin Faisal Hospital, ...
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Dr Shikha Sharma. Coronavirus disease (COVID-19) is an unforgettable word in 2020. World health organization has declared COVID-19 as pandemic and according to the Worldometer site, it has affected 212 countries and territories and has caused approximately 2.8 lakhs deaths so far. According to the various published scientific evidences COVID-19 is an infectious disease caused by new coronavirus that can lead to lung dysfunction. There are 7 coronaviruses that are known to cause disease in humans and among these 3 can cause the severe respiratory infection. These are severe acute respiratory syndrome coronavirus (SARS-CoV) identified in 2002 in China, Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012 in Saudi Arabia and severe acute respiratory syndrome coronavirus2 (SARS-CoV2) commonly called COVID-19 identified in late 2019 in Wuhan, China. SARS-CoV, MERS-CoV and COVID-19 are closely related but COVID-19 spread more quickly than the other two. Over 8000 people from 29 ...
Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child with bronchiolitis in the Netherlands. Infection with the virus has been confirmed worldwide, and has an association with many common symptoms and diseases. Associated diseases include mild to moderate upper respiratory tract infections, severe lower respiratory tract infection, croup and bronchiolitis. The virus is found primarily in young children, the elderly, and immunocompromised patients with acute respiratory illness. It also has a seasonal association in temperate climates. A study performed in Amsterdam estimated the presence of HCoV-NL63 in approximately 4.7% of common respiratory illnesses. Further studies confirmed that the virus is not an emerging virus, but rather one that continually circulates the human population. The first cases of the infection with HCoV-NL63 were found in young children with severe lower respiratory tract infections admitted to ...
Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which do not target the underlying virus infection. The identification of specific inhibitors of coronaviruses or knowledge about how coronaviruses interact with the innate immune system could provide new avenues for developing therapeutics. I investigated the replication of human coronavirus NL63 (HCoV-NL63) in primary human airway epithelial cultures and characterized the activity of the viral papain-like protease 2 (PLP2) domain. Using quantitative real time PCR and imaging techniques I showed that HCoV-NL63
ARTICLE:. J Dyall et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrobial Agents and Chemotherapy DOI: 10.1128/AAC.03036-14 (2014).. WHO:. NIAID Director Anthony S. Fauci., M.D., is available to comment on this research. Co-author Lisa Hensley, Ph.D., associate director for science, NIAID Integrated Research Facility, is also available to discuss the findings.. CONTACT:. To schedule interviews, please contact Anne A. Oplinger, (301) 402-1663, [email protected] For additional information about research on MERS and other coronaviruses by NIAID scientists and grantees, see: http://www.niaid.nih.gov/topics/coronavirus/Pages/default.aspx.. The study was funded, in part, by NIAID grant AI095569.. NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating ...
According to the abstract, Saudi Arabia and United States researchers write:. Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset.. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of ...
Title: Two New Cases of MERS Coronavirus reported in Saudi Arabia.. Subject: Middle East Respiratory Syndrome Coronavirus in Saudi Arabia, daily update.. Source: Saudi Arabia Ministry of Health, full page: (LINK).. Code: [ ]. _____. MOH: 2 New Confirmed Coronavirus Cases Recorded. ___ New Cases Reported: [Sex, Age, Citizenship, Resident in, Health Status, Note ...
Understanding Middle East respiratory syndrome coronavirus (MERS-CoV) transmission in dromedary camels is important, as they consitute a source of zoonotic infection to humans. To identify risk factors for MERS-CoV infection in camels bred in diverse conditions in Burkina Faso, Ethiopia and Morocco, blood samples and nasal swabs were sampled in February-March 2015. A relatively high MERS-CoV RNA rate was detected in Ethiopia (up to 15.7%; 95% confidence interval (CI): 8.2-28.0), followed by Burkina Faso (up to 12.2%; 95% CI: 7-20.4) and Morocco (up to 7.6%; 95% CI: 1.9-26.1). The RNA detection rate was higher in camels bred for milk or meat than in camels for transport (p = 0.01) as well as in younger camels (p = 0.06). High seropositivity rates (up to 100%; 95% CI: 100-100 and 99.4%; 95% CI: 95.4-99.9) were found in Morocco and Ethiopia, followed by Burkina Faso (up to 84.6%; 95% CI: 77.2-89.9). Seropositivity rates were higher in large/medium herds (≥51 camels) than small herds (p = 0.061), in
The US FDA approved niclosamide, an oral anthelminthic drug, in 1982 for human use. It is also included in the essential medicines list of WHO. TFF used this drug to cure several million. It is recently repurposed to cure several viral infections that include SARS-CoV (severe acute respiratory syndrome coronavirus), Zika Virus, and MERS-CoV (Middle East respiratory syndrome coronavirus).. According to clinical trials, niclosamide has the potential to treat SARS-CoV-2. Low oral bioavailability and low absorption rate of niclosamide pose a challenge to develop it as an anti-viral therapy.. ...
The Saudi Arabia Ministry of Health (MOH) has reported a new case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in a citizen of Riyadh,
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related vira …
Novel coronavirus disease 2019 (2019-nCoV) is a global pandemic which threatens all over the world. The first cases were seen in Wuhan, China, in December 2019 (Guo et al. 2020; Chen et al. 2020). It has spread rapidly, and now, there are more than 2.3 million reported cases and 160,000 deaths worldwide. 2019-nCoV may cause multi-system infections especially respiratory infections such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) (Guo et al. 2020; Chen et al. 2020; Sanders et al. 2020). In some cases, infections may be mild (only cough or fever, etc.); however, in some cases, infections may be severe (acute respiratory failure with diffuse pneumonia). In severe cases, there is an exaggerated immune response with low peripheral lymphocyte levels and high cytokine levels. This mechanism of pathogenesis may be responsible for the multiple organ failures (Cao et al. 2019; Lin et al. 2020). In this early stage of the 2019-nCoV, the infection may be treated ...
Health officials say the 68-year-old man was in Bahrain on work-related crop cultivation business from April 18 to May 3. He traveled through Qatars airport on May 4.. One week after arriving back in South Korea he exhibited symptoms of fever and cough and was initially treated on an outpatient basis.. A couple of days later he was hospitalized and was confirmed positive for the Middle East Respiratory Syndrome coronavirus (MERS-CoV).. Health officials say the patient is in stable condition. In addition, they note that family contacts are being watched.. According to the World Health Organization (WHO), they have been notified of 1118 laboratory-confirmed cases of infection with MERS-CoV, including at least 423 related deaths as of May 18.. MERS was first reported in Saudi Arabia in 2012.. ...
The Ministry of Health (MOH} of the Kingdom of Cambodia and the Worl.d Health Organization (WHO) wish to inform the public that currently, there is no case related to the Middle East Respiratory Syndrome Corona virus (MERS-CoV) infections and the Ebola Virus Disease have been detected in Cambodia, so far.. 1. MERS-CoV is a novel coronavirus that causes acute respiratory illness in infected patients. The virus was first reported by the WHO in 2012, and thus far all cases worldwide remained associated with the Arabian Peninsula. The risk of a MERS-CoV outbreak in Cambodia remains low as sustained human-to-human transmission of the virus has not been reported.. The MOHs Department of Communicable Disease Control has, since 2013, been conducting MERS-CoV dissemination workshops in close collaboration with religious leaders, for communities at risk, that cover actions that should be undertaken by pilgrims betore, during and after their Hajj and Umrah pilgrhnages to the Middle East. There is ...
A member of the volunteer group Wuhan Emergency Team, installs a national flag on the car in Wuhan, central Chinas Hubei Province, Feb. 29, 2020. (Xinhua/Xiao Yijiu). The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. BEIJING, March 2 (Xinhua) -- China is in a nationwide mobilization to curb the spread of the novel coronavirus. Here are the latest developments:. -- Chinas daily new confirmed and suspected cases of the novel coronavirus disease (COVID-19) have seen an overall downward trend for two weeks. The number of newly discharged patients nationwide continues to show an upward trend, fluctuating around 3,000 in recent days.. The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. -- A team of doctors in a hospital in central Chinas Hunan Province successfully 3D printed the model of the nidus of a patient infected with the ...
novel coronavirus pneumonia novel coronavirus pneumonia data released by Canadian provinces were released at 18 PM August 13th. Canada has identified 390 new cases of new crown pneumonia in the past 24 hours, 121234 cases of cumulative cases, 6 cases of new deaths and 9012 cases of cumulative deaths. < / P > < p > of the newly confirmed cases, 76 cases were newly diagnosed in Alberta, 78 cases in British Columbia, 104 cases in Quebec, 78 cases in Ontario, 25 cases in Manitoba, 27 cases in Saskatchewan and 2 cases in New Brunswick. Six new deaths on the day were all from Quebec province. (head station reporter Zhang SEN). ...
The official name for the disease that is causing the 2019 novel coronavirus outbreak is COVID-19. The novel coronavirus that causes the disease is known as 2019-nCoV.. International and national health organizations and local health departments are monitoring the COVID-19 outbreak. Due to the situations rapidly changing nature, WOEMA recommends using the following websites to obtain the most current information:. American College of Occupational and Environmental Medicine: ACOEM ...
Have you ever heard about an emerging disease on a TV news program or in a newspaper and wanted to know more about it? Then you may be interested in the Disease Outbreak News (DON), published as needed by the World Health Organization, or WHO, a United Nations agency headquartered in Geneva, Switzerland. The web address is www.who.int/csr/don/en/ .. The DON reports the facts regarding where new disease outbreaks are occurring around the world and how many cases are involved. Most of the recent reports concern Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. MERS-CoV cases are showing up in Saudi Arabia, Qatar and the United Arab Emirates, with a few cases recently noted in China and South Korea.. While not every ARES member would benefit from these reports, members who are also medical professionals might. Wright-Patterson AFB employees and contractors regularly travel to many of the countries mentioned above, and its just possible that some of these emerging illnesses may someday ...
A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle East. We report the deep genome sequencing of the virus directly from a patients sputum sample. Our high-throughput sequencing yielded a substantial depth of genome sequence assembly and showed the minority viral variants in the specimen. Detailed phylogenetic analysis of the virus genome (England/Qatar/2012) revealed its close relationship to European bat coronaviruses circulating among the bat species of the Vespertilionidae family. Molecular clock analysis showed that the 2 human infections of this betacoronavirus in June 2012 (EMC/2012) and September 2012 (England/Qatar/2012) share a common virus ancestor most likely considerably before early 2012, suggesting the human diversity is the result of multiple zoonotic events.
Thanks to FluTrackers for picking up this report from the Saudi Gazette: Ministry accused of falsifying information on MERS cases. It confirms the Arabic reports mentioned here yesterday. A Saudi poet who contracted the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)...
TY - JOUR. T1 - History and recent advances in coronavirus discovery. AU - Kahn, Jeffrey. AU - McIntosh, Kenneth. PY - 2005/11. Y1 - 2005/11. N2 - Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history ...
Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94]. On 15 September 2012, Dr. Zakis findings were posted on ...
Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94] On 15 September 2012, Dr. Zakis findings were posted on ...
As this global concern grows by the minute so should your concern to take action into protecting yourself and your loved ones from this worldwide threat. According to the most recently published article by JAMA (An International peer-reviewed medical journal association), the Coronavirus disease 2019 (COVID-19) is a respiratory illness that results from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Furthermore, the article shares that following initial reports of disease outbreak in China, COVID-19 has spread worldwide with cases identified in at least 67 countries across 6 continents. So if this is an acute respiratory illness why is the world-wide population running out of toilet paper? Ok, I must admit this is funny but not really!. What is coronavirus disease 2019?. According to the CDC, the Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first ...
Till the date, the deadly novel coronavirus has infected 210 countries and territories around the world. The world has reported 3,074,553 positive cases, 211,773 deaths so far. Doctors and researchers across the world are trying to develop drugs and vaccines to prevent the deadly coronavirus. Under such circumstances, hospitals in New York have been quietly testing a common over-the-counter drug as a probable cure for coronavirus (COVID-19) after doctors in China found that elderly survivors were consuming it.. Have you ever heard of a drug named, famotidine? This medicine is especially used for peptic ulcers and GERD (Gastroesophageal Reflux Disease) and sold in oral form under brand name Pepcid. Famotidine is the active compound in the over-the-counter (OTC) heartburn drug Pepcid. It is being examined to treat hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for causing the coronavirus disease 2019 (COVID-19), by Northwell Health in ...
MERS should be considered when a severe respiratory illness occurs in the 2 weeks following residence in or travel to the Middle East or areas of outbreak, and/or close contact with infected individuals. The majority of cases are the result of human-to-human transmission, with peaks of confirmed ...
The U.S. Centers for Disease Control and Prevention confirms the first U.S. case of the newly-emerging Middle East Respiratory Virus or MERS within U.S. borders. Jillian Kitchener reports.
Sigma-Aldrich offers abstracts and full-text articles by [Shamsudeen F Fagbo, Leila Skakni, Daniel K W Chu, Musa A Garbati, Mercy Joseph, Malik Peiris, Ahmed M Hakawi].
Bats, the source of so many viruses, could be the origin of Wuhan coronavirus, say experts - CNN. Deadly coronavirus may have originated in bats: researchers - Weve detected unusual activity from your computer network Up Next Close Rob Gronkowski opens up about everything.. Furthermore, genes for different immune cell subsets, T-cell receptors TCRs , cytokines and chemokines, and interferon-related genes were detected, while genes encoding for natural killer NK cell receptors were largely absent. Meyerholz D. DeGroote fellowship awarded to A. Bats are known to harbor a wide range of viruses including many that are highly pathogenic in humans. The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. In the study, published today Jan. In , a novel alphacoronavirus was identified in an outbreak of respiratory disease in alpacas in the US, which is geographically separated from the bat species that harbor ...
Carlos del Rio executive associate dean for Emory University School of Medicine at Grady Health System, published important information for clinicians in JAMA detailing the 2019 novel coronavirus pandemic, saying that the outbreak is doubling in case size every 6.4 days.
WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...
WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...
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By DAVID J. HILL. The World Health Organization on Thursday declared the outbreak of novel coronavirus a global emergency. While that news may stoke some anxiety among members of the UB community, university leaders want to assure students, faculty and staff that proper precautions are being taken to ensure the health and safety of everyone on campus.. At UB, a team of experienced professionals continues to monitor the situation on campus and has been coordinating with its partners in Erie County, New York State and the U.S. Centers for Disease Control and Prevention.. Consistent communication has been key to keeping the campus community apprised of important information on novel coronavirus, including basic tips on how members of campus can monitor their health.. UB created a coronavirus information website, which contains a list of frequently asked questions, a video featuring Susan Snyder, UBs director of student health services, as well as links to advisories from the CDC and the U.S. ...
TUESDAY, April 21, 2020 (HealthDay News) -- An early analysis of antibody testing from Los Angeles County finds a coronavirus infection rate that is up to 55 times the number of confirmed COVID-19 cases.. According to the researchers behind the study, the vast majority of people infected with the new coronavirus may be going without symptoms or have minimal symptoms.. Its one of the first in-depth analyses of local population infection rates conducted in the United States.. Los Angeles Countys population totals more than 10 million. As the research team noted, by early April, there were 7,994 confirmed cases of COVID-19 reported in the county, including 600 COVID-19 deaths. But new findings from the first round of ongoing antibody blood testing of county residents showed that about 4.1% of adults had antibodies to the coronavirus.. Adjusting for any statistical margin of error, that suggests that between 2.8% to 5.6% of the countys adults have antibodies to the coronavirus, which translates ...
Coronaviruslike viruses previously have been identified in feces of diarrheic foals and adult horses (1, 7, 8, 13, 17). In the present study, a coronavirus associated with diarrhea in a young foal was serially propagated in cell culture and partially characterized. The virus was identified as a coronavirus based on (i) virion size and morphology, (ii) antigenic relatedness to BCV and HEV as determined by serological procedures, and (iii) genetic relatedness to BCV, HCV strain OC43, and MHV as determined by N gene sequence analysis. The virus tentatively is identified as equine coronavirus (ECV) based on the origin of the virus.. The coronavirus N protein has been shown to be highly variable in amino acid composition between the viruses that comprise the three coronavirus antigenic groups but highly conserved within these groups (27, 30). In the present study, a high degree of identity (66.7 to 90.1%) was observed between the N protein sequences of ECV strain NC99 and N protein sequences of group ...
My eyes are killing me…is it coronavirus? If youve found yourself wondering if youve picked up COVID-19 through your eyes, youre not alone. The coronavirus presents with the usual flu symptoms, and pink, irritated eyes with discharge is one of them. Heres what you need to know about the connection between conjunctivitis and coronavirus.. Pink eye can be environmental, viral or bacterial. If you think you have conjunctivitis, or pink eye, there could be several causes. This time of year, you could be reacting to pollen, mold, chemicals and other allergens in the air1. Sometimes bacteria can cause an eye infection flare-up but, by far, the majority of cases of pink eye are caused by viruses. One of these viruses could be coronavirus. But it just as easily could be another culprit.. According to the American Academy of Ophthalmologists, there are cases that show that viruses that cause conjunctivitis were likely transmitted through the air to the eye. It is possible that the coronavirus could ...
Background: In recent years, emerging zoonotic microbes are gaining more attention from the public and policy makers. Explosive outbreaks such as those from avian influenza viruses, severe acute respiratory syndrome (SARS) virus, swine influenza viruses, Hendra virus, Nipah virus, and Middle East respiratory syndrome (MERS) have had tremendous international economic and social impact. In particular, livestock workers have been found to be at increased infection risk and some of the first impacted by a novel pathogen. One of the main obstacles in averting outbreaks of novel microbes is detecting it when it first begins to cross species from animals to man and may not cause severe disease. Often routine diagnostics will fail to detect a new pathogen. The purpose of this research was to evaluate diagnostics for emerging coronaviruses that would be missed with routine diagnostics. Methods: In 2016, I learned how to run new diagnostics adapted at Duke University to detect novel coronaviruses. I took ...
In a nutshell, heart inflammation due to coronavirus infection can happen to people who looks seemingly healthy and without any pre-existing risk factors. Heart inflammation can often be life-threatening.. Does a person with heart disease more likely to get COVID-19 than someone who doesnt have heart disease?. Anyone can get coronavirus infection. However, individuals with pre-existing heart disease or underlying lung conditions can have a more severe infection than others or more likely to have symptoms.. From the findings of COVID-19 so far, it has been found that majority of the people have had mild illness associated with cough, sore throat, body pains and fever, but some people up to 5% had developed pneumonia and chest infection.. Do people with heart disease get severe lung infection if they get infected by coronavirus (COVID-19)?. There have been no reports so far that ascertain that individuals who have pre-existing heart disease may develop severe chest infection with COVID-19, but ...
Abstract Thailand reported the first Middle East respiratory syndrome (MERS) case on 18 June 2015 (day 4) in an Omani patient with heart condition who was diagnosed with pneumonia on hospital admission on 15 June 2015 (day 1). Two false negative RT-PCR on upper respiratory tract samples on days 2 and 3 led to a 48-hour diagnosis delay and a decision to transfer the patient out of the negative pressure unit (NPU). Subsequent examination of sputum later on day 3 confirmed MERS coronavirus (MERS-CoV) infection. The patient was immediately moved back into the NPU and then transferred to Bamrasnaradura Infectious Disea ...
Lu R, Zhao X, Li J et al. Genomic characterization and epidemiology of 2019 novel coronavirus; implications for virus origins and receptor binding. Lancet 2020; 395(102240): 565-574. World Health Organization. 2019-nCoV Situation report-22 on 12 February 2020. Available from: https:// www.who.int/docs/default-source/coronavirus/ situation-reports. Galinsky L, Menachery V. Return of the coronavirus: 2019-nCoV. Viruses 2020; 12(12): 135. Chen Z, Zhang W, Lu Y et al. From SARS - CoV to Wuhan 2019-nCoV outbreak: similarity of early epidemic and prediction of future trends. Cell Press, 2020. Maya C. Fighting a virus, yet again. The Hindu, 2020. p.9. WHO. Novel Coronavirus (2019-nCoV). Situation Report-1, 2020. Sudan P, Bhargava L. Prepared for coronavirus. The Hindu, 2020. How Travelers Around the World Are Dealing With Voluntary Home Quarantines Over Coronavirus Fears. Time. Archived on 24 February 2020. Retrieved 9 March 2020. Another Wuhan University Student from Kerala Tested Positive with ...
Coronavirus vaccine[edit]. The NIH partnered with Moderna in 2020 during the COVID-19 pandemic to develop a vaccine. The final ...
"As the Coronavirus Approaches, Mexico Looks the Other Way". The New York Times. ISSN 0362-4331. Retrieved 2020-03-25.. ... 2020 coronavirus pandemic[edit]. Main article: Shortages related to the COVID-19 pandemic ... "Coronavirus : la demande en ventilateurs et respirateurs artificiels est devenue "colossale", explique un spécialiste dans le ... "Coronavirus, quanti posti in terapia intensiva ci sono in Italia?". 2020-03-16.. ...
Coronavirus[edit]. Further information: Coronavirus disease 2019. According to the United Nations Environment Programme the ... "Coronavirus and Climate Change". WVTF. Retrieved 1 March 2020.. *^ "Coronavirus, climate change, and the environment" ... "Coronavirus Crisis: Exploring the Human Impact on Nature". Chatham House. Retrieved 19 October 2020.. ... "Coronavirus: Fear over rise in animal-to-human diseases". BBC. 6 July 2020. Retrieved 7 July 2020.. ...
Relation to coronaviruses[edit]. Some coronaviruses, e.g. SARS-CoV-1, MERS-CoV, and SARS-CoV-2 are activated by TMPRSS2 and can ... the priming agent of Coronavirus 2 (SARS-CoV-2)". Molecules. 25 (10): 2271. doi:10.3390/molecules25102271. PMC 7287752. PMID ... One experimental candidate as a TMPRSS2 inhibitor for potential use against both influenza and coronavirus infections in ... "TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections". Biochimie. 142: 1-10. doi:10.1016/j. ...
"Coronavirus : plusieurs cas suspects à bord du porte-avions français Charles-de-Gaulle" [Coronavirus: several suspected cases ... "Coronavirus. Le virus introduit sur le Charles de Gaulle en Méditerranée, avant l'escale à Brest". Ouest-France ... "Coronavirus : 50 cas de contamination à bord du "Charles-de-Gaulle", trois marins évacués". Le Parisien ...
"Q&A on coronaviruses (COVID-19)". World Health Organization. Retrieved 6 April 2020.. ... Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)". World Health Organization (WHO). 30 January 2020 ... the virus which causes the coronavirus disease 2019 (COVID-19) and is responsible for the COVID-19 pandemic. The first human ... "How to Respond to the Ongoing Pandemic Outbreak of the Coronavirus Disease (COVID-19)". Retrieved 14 April 2020.. ...
... a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the ... the novel coronavirus'.[102] References[edit]. *^ Parry RL (10 June 2015). "Travel alert after eighth camel flu death". The ... "MERS-CoV , Prevention and Treatment of MERS , Coronavirus , CDC". www.cdc.gov. 13 July 2016. Retrieved 4 April 2017.. ... Butler D (October 2012). "SARS veterans tackle coronavirus". Nature. 490 (7418): 20. doi:10.1038/490020a. PMID 23038444.. ...
IV: SARS coronavirus *Severe acute respiratory syndrome. *V: Orthomyxoviridae: Influenzavirus A/B/C/D *Influenza/Avian ...
Novel Coronavirus Expert Meeting (Japan). *Coronavirus Scientific Advisory Board (Turkey). *Crisis Preparedness and Response ...
Novel Coronavirus Expert Meeting (Japan). *Coronavirus Scientific Advisory Board (Turkey). *Crisis Preparedness and Response ...
The Health Protection (Coronavirus, Restrictions) (England) (No. 4) Regulations 2020. *Coronavirus, Restrictions (All Tiers) ( ... Coronavirus, Restrictions (All Tiers and Self-Isolation) (England) (Amendment) Regulations 2021. *Coronavirus, Restrictions ( ... Health Protection (Coronavirus) Regulations 2020. *Health Protection (Coronavirus, Business Closure) (England) Regulations 2020 ... Coronavirus, Restrictions (Self-Isolation) (England) Regulations 2020. *Coronavirus, Restrictions (Local Authority Enforcement ...
human coronavirus infection. *respiratory distress syndrome. *measles. *meconium aspiration syndrome. *metapneumovirus (hMPV) ...
Coronavirus pandemic in Malaysia. 2020. 2020 Political Crisis. 2020. Movement Control Order. 2020. ...
Coronavirus pandemic in Malaysia. 2020. 2020 Political Crisis. 2020. Movement Control Order. 2020. ...
Don Isaac Abrabanel, a prominent Jewish figure in Spain in the 15th century and one of the king's trusted courtiers who witnessed the expulsion of Jews from Spain in 1492, informs his readers[26] that the first Jews to reach Spain were brought by ship to Spain by a certain Phiros who was confederate with the king of Babylon when he laid siege to Jerusalem. This man was a Grecian by birth, but who had been given a kingdom in Spain. He became related by marriage to a certain Espan, the nephew of king Heracles, who also ruled over a kingdom in Spain. This Heracles later renounced his throne because of his preference for his native country in Greece, leaving his kingdom to his nephew, Espan, by whom the country of España (Spain) derives its name. The Jewish exiles transported there by the said Phiros were descended by lineage from Judah, Benjamin, Shimon and Levi, and were, according to Abrabanel, settled in two districts in southern Spain: one, Andalusia, in the city of Lucena - a city so-called ...
Peiris JS, Poon LL (2011). Detection of SARS Coronavirus. Methods in Molecular Biology. 665. pp. 369-82. doi:10.1007/978-1- ...
"Coronaviruses". pathmicro.med.sc.edu. Archived from the original on 24 May 2005. Retrieved 8 March 2018.. ... Coronaviruses similar to SARS have been found in bats in China, suggesting they may be their natural reservoir.[19] However ... The SARS coronavirus is novel, they say, but this only implies it has mutated or was previously undiscovered, not that it is ... "SARS-like coronavirus found in wild bats: scientists". The People's Daily. 11 September 2005. Retrieved 2007-08-16.. ...
mars 2020). «How Long Will Coronavirus Live on Surfaces or in the Air Around You?». The New York Times (engelsk). ISSN 0362- ... Mandavilli, Apoorva (6. juli 2020). «Airborne Coronavirus: What You Should Do Now». The New York Times (engelsk). ISSN 0362- ... mars 2013). «Receptor for new coronavirus found». Nature News. 495 (7440): 149. doi:10.1038/495149a - via www.nature.com.. ... Coronavirus: Which countries have confirmed cases?». www.aljazeera.com. Besøkt 24. februar 2020.. ...
Wuhan coronavirus: Lunar New Year Cup cancelled by government just hours after HKFA promotes the event ...
Hernández, Eduardo (13 June 2020). "Coronavirus. Este es el plan para reabrir estaciones del Metro, Metrobús y Tren ligero". El ...
"Coronavirus cases in Louisiana jump to six; three more positive tests for New Orleans residents , Coronavirus , nola.com". nola ... "Louisiana Coronavirus COVID-19". Louisiana Department of Health. Retrieved January 19, 2021. Coronavirus information from the ... Analysis of coronavirus data by New Orleans WVUE Fox 8 and the Michael I. Arnolt Center for Investigative Journalism at Indiana ... "Why coronavirus spike in Baton Rouge among young adults is causing a big problem for testing". The Advocate. Retrieved June 26 ...
". "Black doctor's death becomes a symbol of racism in coronavirus care , Coronavirus , The Guardian". O'Brien, Fergal; ...
"Coronavirus (COVID-19) : mesures mises en place par le Musée McCord". Musee McCord. Archived from the original on April 6, 2020 ... The curfew in Montreal and Laval begins at 9:30 p.m. ICI.Radio-Canada.ca, Zone Société-. "Coronavirus : un premier cas est ... ICI.Radio-Canada.ca, Zone Arts-. "Qu'est-ce qui est annulé à cause du coronavirus?". Radio-Canada.ca (in French). Archived from ... "Coronavirus updates, Oct. 6: As hospitalizations and deaths mount, Dubé urges Quebecers to 'stay home'". Montreal Gazette. ...
Hernández, Eduardo (13 June 2020). "Coronavirus. Este es el plan para reabrir estaciones del Metro, Metrobús y Tren ligero". El ...
"Coronavirus cases update India: Total Covid caseload tops 13 million, last 1 million in record 11 days , India News - Times of ... "Coronavirus Updates April 1, 2021: Alia Bhatt tests positive for Covid-19". India Today. 1 April 2021. Retrieved 3 May 2021. ... "Lakshadweep reports first coronavirus case". The Indian Express. 20 January 2021. Retrieved 3 May 2021. "The Mystery Of India's ... "India's coronavirus tally overtakes Brazil; thousands join ritual bath". Reuters. 12 April 2021. Retrieved 3 May 2021. "India ...
"Home -> Health topics -> Coronavirus". WHO. Retrieved 27 April 2020. Liu, Yuan; Ning, Zhi; Chen, Yu; Guo, Ming; Liu, Yingle; ... Ensor, Josie (27 April 2020). "Coronavirus can linger in the air of crowded spaces or toilets for hours, study finds". The ...
Coronavirus , Martín Vizcarra , Francisco Sagasti , POLITICA". Peru21 (in Spanish). Retrieved 2021-02-13. LR, Redacción (2021- ...
"COVID 19 - Corona Virus" (in Portuguese). Retrieved 27 April 2021. "Cape Verde reports first confirmed case of COVID-19 - ... "Corona Virus: Flights suspensions". Cabo Verde Airlines. 17 March 2020. Retrieved 20 March 2020. "Declaration of a state of ... "Coronavirus disease (COVID-19) situation report 72" (PDF). World Health Organization. 1 April 2020. p. 8. Retrieved 20 July ... "Coronavirus disease (COVID-19) situation report 102" (PDF). World Health Organization. 1 May 2020. p. 6. Retrieved 20 July 2020 ...
"Coronavirus info for Albertans updated to March 23". www.alberta.ca. Government of Alberta. March 23, 2020. Archived from the ... "Coronavirus info for Albertans updated to March 17". March 17, 2020. Archived from the original on March 17, 2020. Retrieved ... "Coronavirus info for Albertans updated to March 20". March 20, 2020. Archived from the original on March 21, 2020. Retrieved ... "Coronavirus info for Albertans updated to March 31". March 31, 2020. Archived from the original on April 1, 2020. Retrieved ...
"San Mateo County coronavirus cases: Tracking the outbreak". Los Angeles Times. "Sonoma County coronavirus cases: Tracking the ... "Santa Clara County coronavirus cases: Tracking the outbreak". Los Angeles Times. "Alameda County coronavirus cases: Tracking ... "Contra Costa County coronavirus cases: Tracking the outbreak". Los Angeles Times. "San Francisco County coronavirus cases: ... "Solano County coronavirus cases: Tracking the outbreak". Los Angeles Times. "Marin County coronavirus cases: Tracking the ...
CNN readers ask sharp questions about coronavirus every day. Were answering some of the most popular questions and busting ... CNN readers ask sharp questions about coronavirus every day. Were answering some of the most popular questions and busting ... Coronavirus can be spread unknowingly for many more days than the flu. People with coronavirus might not get symptoms for 14 ... Can I get coronavirus from a package sent from China?. No. "The new coronavirus cannot be transmitted through goods ...
Coronavirus Self-Checker is a tool to help you make decisions on when to seek testing and appropriate medical care. ... Coronavirus Self-Checker. A tool to help you make decisions on when to seek testing and medical care. ... The Coronavirus Self-Checker is an interactive clinical assessment tool that will assist individuals ages 13 and older, and ... Instead of redirecting users to CDCs website, you can add the Coronavirus Self-Checker widget to your website. There, you can ...
Here are some answers to questions about coronavirus and pregnancy. ... Were learning more every day about coronavirus (COVID-19). ... Coronavirus (COVID-19) * Coronavirus (COVID-19): What to Do if ... Can Coronavirus (COVID-19) Cause Problems for a Womans Pregnancy or Her Baby?. Experts are still studying how coronavirus ... Were learning more about coronavirus (COVID-19) each day. Here are some answers to questions about coronavirus and pregnancy. ...
As coronavirus spreads in communities, parents might wonder if their family should get tested. Heres how health care providers ... Coronavirus (COVID-19): ¿Qué significa la cuarentena y el aislamiento? * Coronavirus (COVID-19): Cómo hacer cuarentena o ... What Are the Types of Coronavirus (COVID-19) Tests?. The two main types of tests for coronavirus look for either a current ... To check if someone is infected with coronavirus, health care providers look for pieces of the virus in a sample of saliva ( ...
Testing for Coronavirus (COVID-19) in Nursing Homes. *Infection Prevention and Control Assessment Tool for Nursing Homes ... Responding to Coronavirus (COVID-19) in Nursing Homes. * ...
Experts talking about the coronavirus pandemic call for social distancing, self-quarantine and flattening the curve. What do ... Lessening Coronavirus Impact Its important to know what to do if you feel sick. The coronavirus pandemic is making everyone ... Coronavirus Symptoms: Frequently Asked Questions COVID-19: How to Help Teens Cope at Home Coronavirus: Kidney Damage Caused by ... Coronavirus, Social and Physical Distancing and Self-Quarantine. Facebook Twitter Linkedin Pinterest Print. Infectious Diseases ...
Tags: badhealth, badmedicine, badscience, coronavirus, genetic engineering, medical experiments, outbreak, pandemic, pShuttle, ... has published a detailed article explaining the SARS insertion into the coronavirus and why this is proof that the coronavirus ... Irrefutable: The coronavirus was engineered by scientists in a lab using well documented genetic engineering vectors that leave ... CONFIRMED: CoVid-19 coronavirus found to contain unique "gain-of-function" property "for efficient spreading in the human ...
News and updates about the coronavirus pandemic: Cases in the US, death toll, what you need to know about the virus, how to ... Your questions about coronavirus vaccines, answered By Carolyn Y. Johnson, Aaron Steckelberg, Lena H. Sun, Laurie McGinley and ... What you need to know about the coronavirus variants. The New York variant, B.1.526, has been found in more than a dozen states ... Coronavirus cases in Maryland are the lowest theyve been in months. Heres what you need to know.. ...
News and updates about the coronavirus pandemic: Cases in the US, death toll, what you need to know about the virus, how to ... The last mile of delivering coronavirus shots has become a marathon, with health officials showing up at stores, parks and ... Covid-19 live updates: United States surpasses 600,000 coronavirus deaths. The nationwide death rate has dropped sharply since ... CureVac, latest experimental coronavirus vaccine, proved just 47 percent effective amid spread of variants, preliminary ...
While more than 200,000 Australians have returned home because of the coronavirus pandemic, some have opted to remain in places ... Ryan says he is a little bit concerned about coronavirus, but the situation is not too bad. ... Both men insist there is no way the coronavirus is out of control here. ...
BDJ In Practice and BDJ Team relating to the 2020 coronavirus/COVID-19 pandemic. ... Dentistry and coronavirus. This collection of articles from the British Dental Journal, BDJ In Practice, BDJ Team and Evidence- ... Coronavirus disease 2019 (COVID-19): challenges and management of aerosol-generating procedures in dentistry *Kamran Ali & ... Based Dentistry brings together letters, editorial and articles relating to dentistry and the 2020 coronavirus/COVID-19 ...
Latest Coronavirus News. Yankees place Stanton on 10-day IL with hamstring strain. Aug. 9, 2020 10:47 AM EDT ... Confirmed coronavirus cases in the U.S. reach 5 million, the highest in the world. Aug. 9, 2020 10:09 AM EDT ... ROME (AP) - With confirmed coronavirus cases in the U.S. hitting 5 million Sunday, by far the highest of any country, the ... BOSTON (AP) - A look at coronavirus news from around New England: ___ NEW HAMPSHIRE New Hampshires hospitals are hurting ...
Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December ... Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020 ... Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020 ... Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 ...
The global coronavirus pandemic has brought countries around the world to a standstill. Here are the latest updates on ... April 26 coronavirus news. By James Griffiths, Jenni Marsh, Tara John, Fernando Alfonso III and Amir Vera, CNN ... 37 NYPD members have died from coronavirus. From CNNs Laura Ly Two additional members of the New York Police Department have ... In the US, there are at least 963,168 cases of coronavirus and at least 54,614 related deaths, according to Johns Hopkins ...
Health Protection (Coronavirus) Regulations 2020, revoked by this act. *The Health Protection (Coronavirus, Restrictions) ( ... The Health Protection (Coronavirus, Restrictions) (England) (No. 4) Regulations 2020. *Coronavirus, Restrictions (All Tiers) ( ... Coronavirus, Restrictions (All Tiers and Self-Isolation) (England) (Amendment) Regulations 2021. *Coronavirus, Restrictions ( ... Health Protection (Coronavirus) Regulations 2020. *Health Protection (Coronavirus, Business Closure) (England) Regulations 2020 ...
... , March 30: A look at the latest updates on COVID-19 By Joe Nguyen ... Coronavirus in Colorado, March 29: A look at the latest updates on COVID-19 By Joe Nguyen ... Denver family gives their grandpa hugs and kisses through the window of his memory care facility amid coronavirus pandemic By ... Fake police in Greeley direct driver into roadblock, question her about coronavirus stay-at-home order By Shelly Bradbury ...
Per the Deputy Secretary Defense Memo, Coronavirus Disease 2019 Vaccine Guidance dated 7 December 2020, service members in the ... To learn more, visit: https://tricare.mil/HealthWellness/HealthyLiving/Coronavirus/COVID-Vaccine ...
... English , Español , عربى , हिन्दी The Centers for Disease Control and Prevention offers the most ... COVID-19, also known as the novel coronavirus disease 2019, is a respiratory illness that can spread from person to person. ...
Everyone should follow the government advice on coronavirus. Have a look at our Q&As for pregnant women and parents on ... Coronavirus (COVID19): Advice during pregnancy. All pregnant women should follow the government advice on coronavirus:. * ... Coronavirus (COVID-19). Get the latest advice about coronavirus. Pregnant women should still attend maternity appointments - ... How does coronavirus affect pregnancy?. At the moment, its expected that most pregnant women will experience mild or moderate ...
Track Coronavirus State Legislation U.S. state and local governments have been at the center of the COVID-19 emergency, and ... BOMA Canadas Coronavirus Legal and Human Resources Webinar (April 6, 2020). Yardi Webinar on COVID-19s Impact on Commercial ... BOMA Internationals Coronavirus Resource Center. As we continue to navigate the COVID-19 pandemic, BOMA International is ... NGA Resource: Updated State Actions Relating to Coronavirus With new COVID-19-related policies and orders being released at a ...
What you need to know about coronavirus and COVID-19, including what to do if you think you might be sick, how to keep you and ... Your guide to coronavirus and COVID-19. What you need to know about coronavirus and COVID-19, including what to do if you think ... Is coronavirus spread through the air?. The CDC has updated its website to warn that the coronavirus can spread through the air ... Can coronavirus be spread through the air?. The CDC has updated its website to warn that the coronavirus can spread through the ...
... concerns about coronavirus have spiked significantly among the American public, according to the latest Fortune,SurveyMonkey ... Are you spending more on any of the following as a result of the coronavirus outbreak?. Are you spending less on any of the ... How worried are you that you or someone in your family will be exposed to the coronavirus?. How worried are you that there will ... How likely are you to change or cancel any upcoming domestic travel plans as a result of the coronavirus outbreak?. How likely ...
These are the basic facts when talking about the Delta variant in Italy, the coronavirus variation which is now threatening ...
This document and the FAQs are intended to provide you with general information about the 2019 novel coronavirus, including how ... What is coronavirus?. Coronavirus is a new respiratory virus that originated in Wuhan, China. The virus is contagious and ... How is coronavirus spread? Health authorities have not confirmed how coronavirus is transmitted but suspect it is spread person ... How many people survive coronavirus?. Currently, coronavirus has a fatality rate of less than 3 percent. As such, the majority ...
The coronavirus pandemic has brought countries to a standstill. Heres the latest updates on Covid-19 cases, deaths, government ... A White House coronavirus task force source told CNN earlier this week that the Trump Administrations Warp Speed program had ... The coronavirus outbreak in Peru is spiraling out of control and experts fear it will only worsen. ... Coronavirus pandemic: Updates from around the world. By Rob Picheta and Fernando Alfonso III, CNN ...
COVID-19 Coronavirus Tracker. This tracker provides the number of cases and deaths from novel coronavirus by country, the trend ... This Week in Coronavirus: September 11 to September 17 * September 17, 2020 What We Do and Dont Know About Recent Trends in ... State Data and Policy Actions to Address Coronavirus. There have been over 3 million cases and 131,000 deaths due to COVID-19 ... Low-Income and Communities of Color at Higher Risk of Serious Illness if Infected with Coronavirus. This date note examines the ...
Some coronaviruses cause severe illness that can lead to pneumonia, ... Coronaviruses are a family of viruses. Infection with these viruses can cause mild to moderate respiratory illnesses, such as ... Coronavirus - SARS; Coronavirus - 2019-nCoV; Coronavirus - COVID-19; Coronavirus - Severe acute respiratory syndrome; ... Come in contact with a person with a severe coronavirus infection. *Travelled to a place which had an outbreak of a coronavirus ...
Communicable diseases like coronavirus and the flu can bring a busy workforce to a standstill. Here are ways to prepare your ... Coronavirus and COVID-19 Communicable diseases like coronavirus and the respiratory illness it causes, COVID-19, can bring a ... Need help with a specific HR issue like coronavirus or FLSA? Members can get help with HR questions via phone, chat or email. ... Families First Coronavirus Response Act (FFCRA) mandatory Federal Poster Change, effective April 1 for employers with 500 or ...
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As President Trump canceled a Central Florida rally for Friday due to his and his wifes coronavirus infections, the state ... Coronavirus Coronavirus Q&A: How risky are activities outside my home? What are the chances of getting a false COVID-19 ... Coronavirus CDC abruptly reverses guidance on how coronavirus is transmitted, says it mistakenly posted that COVID-19 is ... For the latest coronavirus updates, visit OrlandoSentinel.com/coronavirus and follow @orlandosentinel on Twitter. ...
  • The Washington Post is providing our daily live updates, comprehensive guide to the pandemic and our Coronavirus Updates newsletter for free, so that all readers have access to this important information about the coronavirus pandemic. (washingtonpost.com)
  • The outbreak within the Vancouver Canucks organization, which has been linked to a variant, is the worst in the NHL this season - and perhaps in North American professional sports since the start of the coronavirus pandemic. (washingtonpost.com)
  • This collection of articles from the British Dental Journal , BDJ In Practice, BDJ Team and Evidence-Based Dentistry brings together letters, editorial and articles relating to dentistry and the 2020 coronavirus/COVID-19 pandemic. (nature.com)
  • BOSTON (AP) - A look at coronavirus news from around New England: ___ NEW HAMPSHIRE New Hampshire's hospitals are hurting financially and bracing for cuts due to the coronavirus pandemic. (ap.org)
  • The Coronavirus Act 2020 (c. 7) is an act of the Parliament of the United Kingdom that grants the government emergency powers to handle the COVID-19 pandemic . (wikipedia.org)
  • The Scottish Parliament agreed a Legislative Consent Motion on 24 March 2020 for the act to apply to Scotland, and subsequently passed the Coronavirus (Scotland) Act 2020 to regulate the devolved response to the Coronavirus pandemic. (wikipedia.org)
  • COVID-19, the coronavirus pandemic, endangers everyone on the planet - including refugees and other people displaced by conflict or persecution. (unhcr.org)
  • These are the basic facts when talking about the Delta variant in Italy, the coronavirus' variation which is now threatening the containment of the pandemic in the country. (forbes.com)
  • Our live coverage of the coronavirus pandemic has ended for the day. (cnn.com)
  • As coronavirus restrictions change, here are answers to frequently asked questions about what people should and should not do while trying to help slow the spread of the pandemic. (orlandosentinel.com)
  • The coronavirus pandemic has changed the way we work and manage employees. (shrm.org)
  • BELGRADE (Reuters) - Novak Djokovic faces a dilemma if it becomes compulsory for players to get vaccinated before they can begin competing once the tennis season resumes following the hiatus created by the coronavirus pandemic, the world number one said on Sunday. (reuters.com)
  • Amazon's CEO Jeff Bezos brought the idea of "customer obsession" to corporate leaders everywhere, but that focus has brought challenges amidst the coronavirus pandemic. (surveymonkey.com)
  • Has your impression of Amazon gotten better or worse during the coronavirus pandemic, or has it stayed about the same? (surveymonkey.com)
  • During the coronavirus (COVID-19) pandemic, businesses, educational institutions, and government agencies must protect the health and safety of people who work, shop, study, or use their facilities. (esri.com)
  • Creating and implementing health and safety plans for sites, facilities, campuses, or other locations is important as schools, colleges, businesses and facilities reopen during the coronavirus (COVID-19) pandemic. (esri.com)
  • The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (yahoo.com)
  • Protecting vulnerable populations during the coronavirus (COVID-19) pandemic is a priority. (esri.com)
  • Join us for a discussion with two water facilities currently operating under shelter-in-place protocols due to the current coronavirus pandemic. (wef.org)
  • Medical professionals have had high hopes for remdesivir since the coronavirus pandemic began. (usatoday.com)
  • Let's switch gears here and talk about the beer industry, because the coronavirus pandemic has really shifted consumer behavior. (yahoo.com)
  • Georgia authorities confirmed the state's first coronavirus-related death on Thursday, as health officials and government leaders scramble to address a COVID-19 pandemic that has already upended everyday life. (ajc.com)
  • On the side of science, virologist Christian Drosten grew his podcast, ' Das Coronavirus-Update ' to millions of followers in the early days of the pandemic. (cnbc.com)
  • On March 25 in Foreign Policy , Micah Zenko called the coronavirus pandemic the "worst intelligence failure in U.S. history" and one that rests squarely on Trump's shoulders, given the warnings that intelligence agencies provided. (foreignpolicy.com)
  • U.S. Senator Chris Murphy wrote in FP earlier this week that the Trump administration has "completely botched" the coronavirus response and that Washington must start planning now for the next pandemic so it is never caught flat-footed again. (foreignpolicy.com)
  • Conspiracy theories and misinformation about the new coronavirus vaccines have proliferated on social media during the pandemic, including through anti-vaccine personalities on YouTube and through viral videos shared across multiple platforms. (reuters.com)
  • The coronavirus pandemic took a toll on Georgia campaign fundraising over the first three months of the year, forcing contenders to find inventive ways to collect cash from donors amid a crisis that's upended the economy. (ajc.com)
  • A man wearing a face mask holds a welcome sign at the Nnamdi Azikiwe International Airport in Abuja, on April 8, as a team of Chinese medics sponsored by China Railway Construction Corp. arrived in Nigeria to help fight the coronavirus pandemic. (foreignpolicy.com)
  • The coronavirus pandemic is no exception. (foreignpolicy.com)
  • Sign up for Foreign Policy 's latest pop-up newsletter, While You Weren't Looking, for a weekly update on the world beyond the coronavirus pandemic. (foreignpolicy.com)
  • If your travel has been impacted by the coronavirus pandemic, you can change or cancel your travel without a change fee or Award redeposit fee. (delta.com)
  • The United Nations on Tuesday suspended new peacekeeping deployments due to the continuing coronavirus pandemic. (cbsnews.com)
  • Both the pandemic outbreak and expenses related to coronavirus appear to be at issue. (cbsnews.com)
  • Coronavirus Australia is an app released by the Australian Government designed to allow users to access information about the COVID-19 pandemic in Australia. (wikipedia.org)
  • ROME (AP) - With confirmed coronavirus cases in the U.S. hitting 5 million Sunday, by far the highest of any country, the failure of the most powerful nation in the world to contain the scourge has been met with astonishment and alarm in Europe. (ap.org)
  • It has the second-highest number of confirmed coronavirus cases in the world after the U.S. (cnbc.com)
  • Infectious disease expert Lisa Maragakis explains how physical distancing can help prevent the spread of the coronavirus and offers tips to practice it correctly. (hopkinsmedicine.org)
  • Everyone is talking about coronavirus disease 2019 (COVID-19). (un.org)
  • These words, coming from UN High Commissioner for Refugees Filippo Grandi, express what the world has been experiencing over the last months: the coronavirus disease, known as COVID-19, knows no borders, no language barriers. (unhcr.org)
  • They are particularly at risk during this coronavirus disease outbreak because they often have limited access to water, sanitation systems and health facilities. (unhcr.org)
  • This document is not intended to be exhaustive, and we encourage you to supplement your knowledge of coronavirus by visiting the website of the Centers for Disease Control and Prevention (CDC). (shrm.org)
  • A forecast published by the US Centers for Disease Control and Prevention now projects more than 127,000 coronavirus deaths in the country by June 27. (cnn.com)
  • If you don't feel well , you may wonder if you have COVID-19, the respiratory disease caused by the new coronavirus . (webmd.com)
  • Coronaviruses are a large family of respiratory viruses with some causing less-severe disease, such as the common cold, and others more severe disease such as Middle-East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). (un.org)
  • Member states struggle to contain coronavirus disease, in Brussels, Greta Thunberg lectures MEPs, and new migration crisis causes unease. (euractiv.com)
  • FILE PHOTO: Medical staff are seen looking after patients inside military hospital at the Heroic Military Academy which takes care of patients with symptoms of the coronavirus disease (COVID-19),in Mexico City, Mexico August 20, 2020. (reuters.com)
  • The outbreak has prompted an explosion of research on the coronavirus and the disease that it causes. (nature.com)
  • F ears mounted on Saturday over the rise of new cases and fatalities outside China from the coronavirus outbreak, as the World Health Organization warned of a shrinking window to stem the spread of the deadly disease. (telegraph.co.uk)
  • ISBE is working in partnership with the Illinois Department of Public Health (IDPH) to ensure we are providing the most current resources and guidance to support Illinois education communities regarding the coronavirus disease 2019 (COVID-19) outbreak. (isbe.net)
  • COVID-19 (coronavirus disease 2019) is an illness caused by a virus. (medlineplus.gov)
  • The illness it causes is called coronavirus disease-19 - COVID-19, for short. (kidshealth.org)
  • FILE PHOTO: Workers wear protective face masks during the outbreak of the coronavirus disease (COVID-19) in Dubai, United Arab Emirates April 23, 2020. (reuters.com)
  • In this article, we give answers to the most common questions we receive from our stakeholders about the coronavirus disease (COVID-19). (ericsson.com)
  • It has two different forms: feline enteric coronavirus (FECV) that infects the intestines and feline infectious peritonitis virus (FIPV) that causes the disease feline infectious peritonitis (FIP). (wikipedia.org)
  • Now, stunning new evidence has emerged that proves the coronavirus was definitely engineered in a laboratory and may have been deliberately injected into patients as part of a Chinese vaccine experiment gone wrong. (naturalnews.com)
  • Experts tackle lingering coronavirus vaccine fears. (washingtonpost.com)
  • Can you test positive for coronavirus after getting a vaccine? (usatoday.com)
  • Moderna's COVID-19 vaccine protects against two variants of the coronavirus that have emerged from Britain and South Africa, according to a company study. (usatoday.com)
  • Brazil on Saturday began distributing the 2 million doses of the AstraZeneca coronavirus vaccine that arrived from India Friday, Reuters reports . (yahoo.com)
  • Dr. Janette Nesheiwat praises the effectiveness of the single-shot Johnson and Johnson vaccine for the coronavirus on 'America's Newsroom' and stresses the importance of as many people getting vaccinated as possible. (yahoo.com)
  • Pattison said the WHO was encouraged by YouTube's announcement on coronavirus vaccine misinformation. (reuters.com)
  • Britain has authorized an easy-to-handle coronavirus vaccine and decided to stretch out the time between doses to allow more people to get some level of protection faster as infections surge. (pbs.org)
  • It's still possible to test positive for the coronavirus even after getting vaccinated, experts said. (usatoday.com)
  • And the gene testing company 23andMe wrote a blog post about preliminary unpublished data suggesting that people with Type O blood were less likely to test positive for the coronavirus than others. (nbcnews.com)
  • White House aide Hope Hicks Hicks tests positive for the coronavirus. (yahoo.com)
  • Mar 16, 2020 · Actor Idris Elba said in a tweet on Monday that he had tested positive for the coronavirus . (yahoo.com)
  • The two main types of tests for coronavirus look for either a current infection or a past infection. (kidshealth.org)
  • To see if someone had coronavirus in the past, health care providers look for antibodies , which the body makes after an infection. (kidshealth.org)
  • Once a person has been infected by a coronavirus, the infection can spread to a healthy person (person-to-person transmission). (medlineplus.gov)
  • You may need further testing if your infection is due to a severe form of coronavirus. (medlineplus.gov)
  • To date there is no specific treatment for coronavirus infection. (medlineplus.gov)
  • Studies in China and New York both found that people with Type A blood had a greater risk of coronavirus infection than those with other blood types, while those with Type O had a lower risk. (nbcnews.com)
  • Welcome to Euractiv's EU Tweets of the Week VDL issues Boris an Ozzie correction, efforts continue to stop coronavirus infection and Irish give tight result in general election. (euractiv.com)
  • The total number of COVID-19 infections markedly exceeds previous coronavirus infection outbreaks including SARS in 2002 (8,098 infections, 774 deaths) and MERS in 2012 (2,458 infections, 848 deaths),4,5 implying a much higher case-fatality rate in SARS and MERS, however, the limited horizontal transmission of these viruses helped contain the outbreaks. (kumc.edu)
  • The U.S. intelligence community says China has underreported its total coronavirus infection figures. (foreignpolicy.com)
  • The White House has moved on from calling the coronavirus the "Chinese virus" and is instead pointing to China's allegedly misleading infection figures. (foreignpolicy.com)
  • According to Maria van Kerkhove, an epidemiologist with the World Health Organization, the WHO's definition of a coronavirus infection includes asymptomatic cases for a reason. (foreignpolicy.com)
  • Importantly, K22 inhibitsa broad range of coronaviruses, including Middle East respiratory syndrome coronavirus(MERS CoV), and efficient inhibition wasachieved in primary human epithelia cultures representing the entry port of human coronavirus infection. (slideshare.net)
  • Feline enteric coronavirus is responsible for an infection of the mature gastrointestinal epithelial cells (see also enterocytes, brush border, microvilli, villi). (wikipedia.org)
  • As the U.S. coronavirus case count passed 4.3 million on Monday, companies launched the final phase of testing for two potential COVID-19 vaccines . (medicinenet.com)
  • Although drugmakers and researchers are working on various treatments, vaccines are at the heart of the long-term fight to stop the new coronavirus, which has killed more than a million people, infected more than 38 million and crippled the global economy. (reuters.com)
  • What are the signs and symptoms of coronavirus? (shrm.org)
  • If you exhibit symptoms of coronavirus within two weeks of traveling from China, you should contact a health care professional and mention your recent travel. (shrm.org)
  • If you have had close contact with someone exhibiting coronavirus symptoms who has recently traveled from China, you should call ahead to a health care professional and mention your close contact and the person's recent travel. (shrm.org)
  • As previously, tests will still be reserved for those who have symptoms of coronavirus, healthcare workers, people who work in elderly care homes and those in certain risk groups. (forbes.com)
  • It's important to understand that if you have asthma and you get coronavirus (COVID-19), you're at higher risk of severe symptoms. (webmd.com)
  • However, almost everyone with coronavirus and severe symptoms will have a fever as well as possible chills, diarrhea, loss of smell and taste and muscle pain. (webmd.com)
  • If you have asthma and you have an attack with shortness of breath but no fever, chances are it's not coronavirus, especially if your symptoms improve with your asthma inhaler. (webmd.com)
  • Is it safe to take acetaminophen/Tylenol to treat coronavirus symptoms? (webmd.com)
  • At the end of 2019, a new type of coronavirus, called SARS-CoV-2, began making people sick with flu-like symptoms. (kidshealth.org)
  • They initially discovered that K22 had antiviral activity against a relatively harmless coronavirus that causes mild cold-like symptoms in humans. (slideshare.net)
  • Florida has seen a massive surge in coronavirus cases and hospitalizations in recent weeks. (buzzfeed.com)
  • Poland's national stadium is being transformed into a field hospital for Warsaw and the government is building temporary medical facilities elsewhere, as the surge in coronavirus cases strains healthcare facilities to breaking point. (rte.ie)
  • By following these important precautions and by planning ahead, we can help contain and prevent the spread of coronavirus. (shrm.org)
  • Lithuanian soldiers, wearing face masks to prevent the spread of coronavirus, attend a ceremony marking the 75nd anniversary of the end of World War II in Vilnius on May 8, 2020. (politico.com)
  • The paper, entitled, " Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag," concluded that the engineering of coronavirus with such gene sequences was "unlikely to be fortuitous in nature," providing strong scientific support for the theory that the coronavirus is an engineered bioweapon that escaped laboratory containment in China. (naturalnews.com)
  • The current CDC guidance on considerations for travelers is available at https://www.cdc.gov/coronavirus/2019-ncov/travelers/travel-in-the-us.html . (longbeach.gov)
  • Three in 10 people (31%) say they're using Amazon now more than they were before the start of the coronavirus outbreak, while 46% say they're using it about as much as before and 18% are using it less than before. (surveymonkey.com)
  • Since the start of the coronavirus outbreak, have you been shopping on Amazon more, less, or about as much as before? (surveymonkey.com)
  • As the United States drifts toward what appears likely to become a shift between efforts to contain COVID-19 and a new policy of voluntary or even mandatory social distancing, the state with (so far) the most extensive outbreak of the coronavirus, Washington, is holding a presidential primary election tomorrow. (nymag.com)
  • This is a running list of schools and colleges in Colorado that are closed because of the outbreak of the coronavirus. (denverpost.com)
  • On 25 March 2021, MPs voted by 484 to 76 to extend the emergency coronavirus powers for another six months. (wikipedia.org)
  • Because what this global coronavirus outbreak has undeniably demonstrated, is that the health of every person is linked to the health of the most marginalized and vulnerable members in a society. (unhcr.org)
  • Read our coverage on the global coronavirus outbreak, including live updates, health and safety information, frequently asked questions and more. (nytimes.com)
  • He said if a significant number of people were getting coronavirus through their eyes, doctors would probably see more Covid-19 patients with conjunctivitis, also known as pink eye (though having pink eye doesn't necessarily mean you have coronavirus ). (cnn.com)
  • As cases of coronavirus (COVID-19) continue, parents might wonder if their family should get tested, especially if someone is sick or was around a person who has the virus. (kidshealth.org)
  • What Are the Types of Coronavirus (COVID-19) Tests? (kidshealth.org)
  • Now that the new coronavirus and COVID-19, the illness it causes, are spreading among communities in the United States and other countries, phrases such as "physical distancing," "self-quarantine" and "flattening the curve" are showing up in the media. (hopkinsmedicine.org)
  • People who have been exposed to the new coronavirus and who are at risk for coming down with COVID-19 might practice self-quarantine . (hopkinsmedicine.org)
  • Two additional members of the New York Police Department have died due to complications from Covid-19, bringing the total number of NYPD deaths to 37, according to a daily NYPD coronavirus report. (cnn.com)
  • The mass hysteria over COVID-19, " The Coronavirus," supplies the remotely thoughtful with much food for thought. (lewrockwell.com)
  • NHS COVID-19 app Help stop the spread of coronavirus by downloading the official NHS contact tracing app for England and Wales. (www.nhs.uk)
  • BOMA International continues to monitor the latest COVID-19 developments, and additional resources are being posted regularly to this webpage ( www.boma.org/coronavirus ). (boma.org)
  • What you need to know about coronavirus and COVID-19, including what to do if you think you might be sick, how to keep you and your family safe and tips on what to do while staying home. (usatoday.com)
  • Communicable diseases like coronavirus and the respiratory illness it causes, COVID-19, can bring a busy workforce to a standstill. (shrm.org)
  • The CDC recommends a COVID-19 test called a nasopharyngeal swab fo coronavirus. (webmd.com)
  • The solution includes a collection of ArcGIS applications used to create a COVID-19 health safety plan (for example, temperature screening locations, handwashing or sanitizer stations, personal protective equipment (PPE) stations, isolation areas, etc.), estimate crowd capacities and monitor social distancing, track cleaning and disinfecting, monitor restocking of PPE stations, and report coronavirus-related problems and issues. (esri.com)
  • What's more, a team of researchers from Johns Hopkins School of Medicine found evidence of the coronavirus (SARS-CoV-2) in the middle ear of COVID-19 patients in an autopsy study published in JAMA Otolaryngology - Head & Neck Surgery . (aarp.org)
  • With the most recent outbreak of coronavirus, now known by its official name COVID-19, announced over the weekend in Italy, the EU is taking precautions to stem the spread of the virus. (euractiv.com)
  • A spokesman for Liverpool University Hospitals NHS Foundation Trust said: "We can confirm that a second member of staff at Aintree University Hospital has tested positive for coronavirus (Covid-19). (yahoo.com)
  • Current estimates of COVID-19's case fatality rate - a measure of the proportion of infected people who eventually die - suggest that the coronavirus is less deadly than the pathogens behind other large-scale outbreaks, such as of SARS (severe acute respiratory syndrome), MERS (Middle East respiratory syndrome) and Ebola. (nature.com)
  • On March 14, the City of Long Beach announced temporary precautionary changes to City operations in order to reduce the risk of community spread of Coronavirus (COVID-19). (longbeach.gov)
  • The news about COVID-19 or the coronavirus isn't getting any better. (nea.org)
  • For the latest information on McGill's response to the coronavirus (COVID-19) outbreak, please visit https://www.mcgill.ca/coronavirus . (mcgill.ca)
  • How Does Coronavirus (COVID-19) Spread? (kidshealth.org)
  • Is Coronavirus (COVID-19) Dangerous to Children? (kidshealth.org)
  • Connor Reed, a British man who works at a school in Wuhan, explains how it felt to have the Covid-19 coronavirus, discusses what life is like after 40 days in lockdown and how he thinks people in the UK would cope in similar circumstances. (phpbb.com)
  • There have been some news reports about vitamin D reducing the risk of coronavirus. (www.nhs.uk)
  • In the US, there are at least 963,168 cases of coronavirus and at least 54,614 related deaths, according to Johns Hopkins University's tally. (cnn.com)
  • And Vice President Mike Pence warned of "thousands of more cases of coronavirus," while saying Americans returning from Europe would need to self-quarantine for two weeks. (ajc.com)
  • Two weeks ago, Paxton issued guidance that abortion services were included in the Governor's temporary suspension of "non-essential" procedures in an effort to shore up medical resources needed to fight the coronavirus outbreak. (cbsnews.com)
  • Research disputing the effectiveness of hydroxychloroquine as a treatment for coronavirus has been retracted after questions were raised over the data. (cnn.com)
  • Polk County, due to nursing-home outbreaks, has the most coronavirus fatalities in the region with 531, followed by 474 in Orange, 303 in Brevard, 259 in Volusia, 222 in Seminole, 194 in Lake, 156 in Osceola, and 70 in Sumter. (orlandosentinel.com)
  • Russia has insisted that it is not under-reporting coronavirus fatalities. (cnbc.com)
  • Experts have questioned the accuracy of Russian data when it comes to the coronavirus, although the country has insisted that it is not under-reporting coronavirus fatalities. (cnbc.com)
  • President Trump harshly criticized the World Health Organization during his daily Coronavirus Task Force briefing Tuesday. (cbsnews.com)
  • Cuomo said the state saw the lowest daily death rate since it started trending downward -- with at least 35 new coronavirus deaths. (cnn.com)
  • As President Trump canceled a Central Florida rally for Friday due to his and his wife's coronavirus infections, the state reported another 2,660 cases and 110 new resident deaths. (orlandosentinel.com)
  • While it's true that how coronavirus deaths are recorded does differ between nations, Russia's death toll is certainly low compared to its regional peers, at around 10% of the numbers seen elsewhere in Europe. (cnbc.com)
  • Health experts aren't sure whether antibodies protect a person from future coronavirus infections. (kidshealth.org)
  • How is coronavirus spread? (shrm.org)
  • Health authorities have not confirmed how coronavirus is transmitted but suspect it is spread person-to-person. (shrm.org)
  • There are many other coronaviruses circulating in animals, but they haven't spread to humans. (medlineplus.gov)
  • Human coronaviruses that cause the common cold spread from person-to-person. (medlineplus.gov)
  • For the latest information about how to stop the spread or to learn more about the federal response, visit coronavirus.gov , cdc.gov/coronavirus , and USA.gov/Coronavirus . (usda.gov)
  • An inmate early release program aimed at controlling the spread of the coronavirus in Virginia prisons will end on July 1. (nbc12.com)
  • This virus is a new coronavirus that has spread throughout the world. (medlineplus.gov)
  • In terms of slowing the spread of coronavirus, there were new signs of hope on Monday. (medicinenet.com)
  • We are taking precautionary measures to ensure the health and safety of employees, to minimize the impact on the company's operations and to prevent further spread of the coronavirus. (ericsson.com)
  • As the spread of coronavirus has caused more Americans to isolate indoors, there have been many effects both on how people use the internet and on infrastructure itself-everything from changing behaviors, to reshaping work and education, to putting pressure on the grid. (theonion.com)
  • Coronavirus is a new respiratory virus that originated in Wuhan, China. (shrm.org)
  • The coronavirus emerged in Wuhan, a city of 11 million people in China's Hubei province, in late 2019. (nature.com)
  • Bloomberg Opinion) -- Just as coronavirus infections weaken, European countries lift foreign travel restrictions and people gear up for the possibility that we might actually get on an airplane again, one of the world's largest tourism markets is effectively shutting down. (yahoo.com)
  • After 10 weeks of coronavirus restrictions, Italian shops, restaurants, bars and beach clubs were allowed to throw open their doors Monday. (politico.com)
  • As Wolfgang Wodarg-a German medical doctor who once ran his own health department with a system for monitoring flu diseases among people within an area of some 150,000 inhabitants- informs us, coronaviruses constitute anywhere up to 15% of respiratory diseases. (lewrockwell.com)
  • We are working with governments, which lead the coronavirus response, to ensure that people forced to flee are included in preparation and response plans. (unhcr.org)
  • How does UNHCR help refugees and internally displaced people in the fight against the coronavirus? (unhcr.org)
  • We've scaled up our work to keep refugees and internally displaced people safe by responding to the coronavirus with life-saving support, including water, medical care and hygiene materials. (unhcr.org)
  • A majority of people (63%) say they are worried they won't have enough money to pay their monthly bills, and a similar number (64%) say the coronavirus outbreak has disrupted their typical household spending. (surveymonkey.com)
  • How many people survive coronavirus? (shrm.org)
  • It's now encouraging people to wear them to prevent the coronavirus from spreading. (cnn.com)
  • Rarely, certain severe coronavirus infections may lead to death, especially in older people, children, or people with chronic conditions. (medlineplus.gov)
  • Employees, students, customers and other people returning to a facility may be concerned about large crowds or other conditions that increase the likelihood of being exposed to the coronavirus. (esri.com)
  • The Coronavirus Site Safety solution provides a complete set of capabilities that help Health Safety Officers, Security Officers, Janitorial Staff, and other employees collaborate to operationalize the site health safety plan in order to keep people at the facility, campus, etc. healthy and safe. (esri.com)
  • The idea is to have a more accurate census of people who have encountered the coronavirus and produced antibodies and provide data that would help the exit strategies' decision-making. (euractiv.com)
  • The coronavirus can stay aloft for hours in tiny droplets in stagnant air , infecting people as they inhale, mounting scientific evidence suggests. (nytimes.com)
  • It gives 12 weeks of paid leave to people caring for children whose schools are closed or whose child care provider is unavailable because of the coronavirus. (nytimes.com)
  • On Thursday, NHS England confirmed the total number of people with coronavirus in the UK rose to 590. (yahoo.com)
  • several people who were in close contact with the president in the days before his diagnosis also have coronavirus infections. (yahoo.com)
  • We had prepared a plan in recent days, because it was clear what has happened could somehow happen,' Health Minister Speranza said as doctors tested hundreds of people who might have come into contact with the coronavirus sufferers. (telegraph.co.uk)
  • More than 14,700 people have died from the new coronavirus in the United States, according to Johns Hopkins University. (cbsnews.com)
  • The move came as the country of 38 million people saw a new 24-hour record of 13,632 coronavirus cases on Friday. (rte.ie)
  • Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases. (un.org)
  • This date note examines the share of non-elderly adults at higher risk of serious illness if infected with coronavirus by race/ethnicity and household income in 2018. (kff.org)
  • Some coronaviruses cause severe illness that can lead to pneumonia, and even death. (medlineplus.gov)
  • Most of them cause illness in animals, but seven known types of coronaviruses cause illness in humans. (jdrf.org)
  • SARS-CoV-2 is related to other coronaviruses that cause illness in humans such as those that cause SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). (jdrf.org)
  • It is caused by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). (medlineplus.gov)
  • Severe coronavirus infections may require hospitalization and breathing support. (medlineplus.gov)
  • MERS is caused by the MERS-CoV coronavirus. (medlineplus.gov)
  • Follow-up experiments showed that the compound was effective against all other coronaviruses tested, including the SARS and MERS coronaviruses. (slideshare.net)
  • Dubai's two major alcohol distributors have partnered to offer home delivery of beer, spirits and wine as the new coronavirus now threatens a crucial source of tax and general revenue for the rulers of this Islamic city-state. (cbsnews.com)
  • Clorox, a major manufacturer of dietary supplements and household products, has partnered with the Cleveland Clinic on a guide to help businesses cope with coronavirus provisions in the workplace. (nutraingredients-usa.com)
  • www.cbsnews.com /news/ idris-elba-coronavirus . (yahoo.com)
  • Also, how alert should educators be of potential bullying as a result of fears surrounding coronavirus? (nea.org)
  • Russia reported a further 8,764 coronavirus cases Wednesday, pushing its total case tally to 308,705, its coronavirus crisis center said. (cnbc.com)
  • However, while there does seem to be a decline in new daily cases across the country - Wednesday marked the fifth day in a row that fewer than 10,000 new cases were announced - the coronavirus crisis is still a challenge unlike any faced by President Putin in his two decades in power . (cnbc.com)
  • As coronavirus cases continue to climb in the U.S., another public health crisis is brewing. (cbsnews.com)
  • Please check the menu below to access recordings of our recent coronavirus-related webcast events. (wef.org)
  • Common human coronaviruses cause mild to moderate illnesses, such as the common cold . (medlineplus.gov)
  • Mild coronavirus infections, such as the common cold, will go away in a few days with rest and self care at home . (medlineplus.gov)
  • 1. Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus Anna Lundin1. (slideshare.net)
  • If you're a health care worker or taking care of someone at home who has coronavirus, it's smart to wear eye protection, said Dr. Thomas Steinemann, clinical spokesperson for the American Academy of Ophthalmology. (cnn.com)
  • To check if someone is infected with coronavirus, health care providers look for pieces of the virus in a sample of saliva (spit) or mucus. (kidshealth.org)
  • Dr. Deborah Birx said a coronavirus antibody test could be available "within this month" and says "I've really called on every university and every state to develop ELISA's, you can buy the antigens and the controls online, and really work to test entire health care communities in your state and support them that way. (cnn.com)
  • The Norwegian Institute of Public Health (FHI) has said it does not recommend widespread testing in the country's battle against the coronavirus. (forbes.com)
  • A Health Safety Officer who needs to initiate the site safety planning process can use the Coronavirus Site Safety Form to add a site where a health safety plan will be created. (esri.com)
  • Coronavirus Site Safety Manager can be used by a Health Safety Officer to manage the status of health safety plans. (esri.com)
  • The Coronavirus Site Safety Plan Map Editor can be used to locate health resources and create social distance capacity estimates required for a health safety plan. (esri.com)
  • The Coronavirus Site Safety Map Viewer can be used by stakeholders to review a health safety map for a given location. (esri.com)
  • The Coronavirus Wellness Checks solution can be used by Public Health staff to engage community volunteers, register homebound individuals, conduct regular wellness checks, and monitor the wellness of vulnerable individuals. (esri.com)
  • From the latest news to binge-watching suggestions to tips for caring for your mental health, we've got everything you need to know about coronavirus to stay safe and make the most of your time spent at home. (buzzfeed.com)
  • Through our partnership with the Mount Sinai Health System, we treated more than 300 coronavirus patients in New York, including 190 at the park site. (samaritanspurse.org)
  • Apr 01, 2020 · Idris Elba is sharing a health update after revealing he tested positive for coronavirus on March 16. (yahoo.com)
  • ISLAMABAD-The coronavirus has reached into the top ranks of Pakistan's government, with the foreign minister and a health adviser to Prime Minister Imran Khan testing positive in the past week. (wsj.com)
  • The outbreak, which the World Health Organisation has now declared a global health emergency, is caused by a new type of an old foe: coronaviruses are common enough to be one of the causes of the common cold. (ox.ac.uk)
  • View Long Beach Unified School District's Coronavirus Response for continuing updates on schooling options and related plans for the fall semester, home learning opportunities, and meal schedule (the district will continue to provide free meals for children at more than 30 locations). (longbeach.gov)
  • Read the latest updates on coronavirus in Colorado here. (denverpost.com)
  • Follow the latest coronavirus updates here. (cbsnews.com)
  • Coronaviruses are a family of viruses. (medlineplus.gov)
  • Coronaviruses are a family of viruses that cause respiratory illnesses. (jdrf.org)
  • State and local leaders around the U.S. are hoping freebies and other incentives can boost vaccination rates as demand for a coronavirus shot slows. (washingtonpost.com)
  • 39 states are now addressing the coronavirus emergency with Medicaid/CHIP Disaster Relief State Plan Amendments (SPAs). (kff.org)
  • The coronavirus emergency relief package gives many American workers paid leave if they need to take time off because of the virus. (nytimes.com)
  • So while looking for a specific virus, for example, the coronavirus, you can examine the total population. (lewrockwell.com)
  • Russia's coronavirus cases surpassed 300,000 on Wednesday, cementing its position as the second-worst-hit country from the virus after the U.S., but there are increasing questions over the country's low death toll. (cnbc.com)
  • The South Asian nation has been struggling to stop the virus from spreading, although the rate of growth in new coronavirus cases has slowed from a peak last month. (wsj.com)
  • Feline coronavirus (FCoV) is a positive-stranded RNA virus that infects cats worldwide. (wikipedia.org)
  • FCoV type II is a recombinant virus type I with spike genes (S protein) replacement from FCoV by the canine coronavirus (CCoV) spikes. (wikipedia.org)
  • The Coronavirus" is, in reality, but the latest discovered variant of a family of corona viruses that are located in all acute respiratory diseases. (lewrockwell.com)
  • Trump announces in an evening interview on Fox News that he and the first lady are being tested for the coronavirus. (yahoo.com)
  • It was revealed later that Trump had actually tested positive on a rapid coronavirus test when he returned to the White House and was awaiting the results of a more sensitive lab test. (yahoo.com)
  • The governor's announcement came a day after President Donald Trump announced "strong but necessary" steps to keep new cases of the coronavirus from entering the U.S. by suspending most travel from Europe for 30 days. (ajc.com)
  • Hence," Dr. Wodarg says, "it's just normal that a big part of viruses are coronaviruses. (lewrockwell.com)
  • However," Wudarg adds, whether these patients die of the coronavirus itself or of other viruses that are accompanied by the coronavirus, this is not something that can be determined with surety (italics added). (lewrockwell.com)
  • UNHCR is seeking US$745 million to help priority countries hosting large populations of refugees prevent and respond to the coronavirus. (unhcr.org)
  • Feline coronavirus is found in cat populations around the world. (wikipedia.org)