A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.
A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It contains hemagglutinin-esterase.
A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other.
Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.
A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.
A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.
Virus diseases caused by CORONAVIRIDAE.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.
A species of CORONAVIRUS causing infections in chickens and possibly pheasants. Chicks up to four weeks old are the most severely affected.
A species in the genus CORONAVIRUS causing upper and lower RESPIRATORY TRACT INFECTIONS. It shares the receptor used by the SARS VIRUS.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. It is separate but antigenically related to MURINE HEPATITIS VIRUS.
A species of CORONAVIRUS causing enteritis in turkeys and pullets.
A mutant strain of TRANSMISSIBLE GASTROENTERITIS VIRUS causing mild or subclinical respiratory infections in young SWINE. It may also play a role in post-weaning porcine respiratory disease complex, especially when combined with other respiratory agents.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Ribonucleic acid that makes up the genetic material of viruses.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.
Glycoproteins found on the membrane or surface of cells.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Proteins found in any species of virus.
The family of civets which are small and medium-sized Old World carnivores, often striped or spotted.
Established cell cultures that have the potential to propagate indefinitely.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An acute, highly contagious virus disease of turkeys characterized by chilling, anorexia, decreased water intake, diarrhea, dehydration and weight loss. The infectious agent is a CORONAVIRUS.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)
Infectious diseases that are novel in their outbreak ranges (geographic and host) or transmission mode.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
INFLAMMATION of the LIVER in animals due to viral infection.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
The temporal sequence of events that have occurred.
Substances elaborated by viruses that have antigenic activity.
Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.
The relationships of groups of organisms as reflected by their genetic makeup.
The functional hereditary units of VIRUSES.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The specificity of a virus for infecting a particular type of cell or tissue.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
Specific hemagglutinin subtypes encoded by VIRUSES.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A family in the suborder Feliformia, order CARNIVORA, comprising one genus Nandinia binotata.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Inflammation of the lung parenchyma that is caused by a viral infection.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A general term for diseases produced by viruses.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The interactions between a host and a pathogen, usually resulting in disease.
A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES); RETROTRANSPOSONS; and bacterial insertion elements but also in some cellular genes.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
Proteins prepared by recombinant DNA technology.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Inflammation of any segment of the SMALL INTESTINE.
Diseases of domestic swine and of the wild boar of the genus Sus.
DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.
Antibodies produced by a single clone of cells.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The species Delphinapterus leucas, in the family Monodontidae, found primarily in the Arctic Ocean and adjoining seas. They are small WHALES lacking a dorsal fin.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC
A genus of the family CORONAVIRIDAE characterized by enveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. Toroviruses have been found in association with enteric infections in horses (Berne virus), cattle (Breda virus), swine, and humans. Transmission probably takes place via the fecal-oral route.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.
Viruses whose genetic material is RNA.

Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. (1/471)

Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthesized by in vitro transcription and translation from the replicase gene demonstrated both cis and trans cleavage activities for PLP-1. We have cloned and overexpressed the PLP-1 domain in Escherichia coli by using a T7 RNA polymerase promoter system or as a maltose-binding protein (MBP) fusion protein. With both overexpression systems, the recombinant PLP-1 exhibited trans cleavage activity when incubated with in vitro-synthesized viral polypeptide substrates. Subsequent characterization of the recombinant PLP-1 revealed that in vitro trans cleavage is more efficient at 22 degrees C than at higher temperatures. Using substrates of increasing lengths, we observed efficient cleavage by PLP-1 requires a substrate greater than 69 kDa. In addition, when PLP-1 was expressed as a polypeptide that included additional viral sequences at the carboxyl terminus of the predicted PLP-1 domain, a fivefold increase in proteolytic activity was observed. The data presented here support previous data suggesting that in vitro and in vivo cleavage of the ORF 1a polyprotein by PLP-1 can occur in both in cis and in trans. In contrast to the cleavage activity demonstrated for PLP-1, no in vitro cleavage in cis or in trans could be detected with PLP-2 expressed either as a polypeptide, including flanking viral sequences, or as an MBP fusion enzyme.  (+info)

Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. (2/471)

Human coronaviruses (HuCV) cause common colds. Previous reports suggest that these infectious agents may be neurotropic in humans, as they are for some mammals. With the long-term aim of providing experimental evidence for the neurotropism of HuCV and the establishment of persistent infections in the nervous system, we have evaluated the susceptibility of various human neural cell lines to acute and persistent infection by HuCV-229E. Viral antigen, infectious virus progeny and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, and oligodendrocytic MO3.13 cell lines, were all susceptible to an acute infection by HuCV-229E. The CHME-5 immortalized fetal microglial cell line was not susceptible to infection by this virus. The MO3.13 and H4 cell lines also sustained a persistent viral infection, as monitored by detection of viral antigen and infectious virus progeny. Sequencing of the S1 gene from viral RNA after approximately 130 days of infection showed two point mutations, suggesting amino acid changes during persistent infection of MO3.13 cells but none for H4 cells. Thus, persistent in vitro infection did not generate important changes in the S1 portion of the viral spike protein, which was shown for murine coronaviruses to bear hypervariable domains and to interact with cellular receptor. These results are consistent with the potential persistence of HuCV-229E in cells of the human nervous system, such as oligodendrocytes and possibly neurons, and the virus's apparent genomic stability.  (+info)

Acute and persistent infection of human neural cell lines by human coronavirus OC43. (3/471)

Human coronaviruses (HuCV) are recognized respiratory pathogens. Data accumulated by different laboratories suggest their neurotropic potential. For example, primary cultures of human astrocytes and microglia were shown to be susceptible to an infection by the OC43 strain of HuCV (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). We speculate that the neurotropism of HuCV will lead to persistence within the central nervous system, as was observed for murine coronaviruses. As a first step in the verification of our hypothesis, we have characterized the susceptibility of various human neural cell lines to infection by HuCV-OC43. Viral antigen, infectious virus progeny, and viral RNA were monitored during both acute and persistent infections. The astrocytoma cell lines U-87 MG, U-373 MG, and GL-15, as well as neuroblastoma SK-N-SH, neuroglioma H4, oligodendrocytic MO3.13, and the CHME-5 immortalized fetal microglial cell lines, were all susceptible to an acute infection by HuCV-OC43. Viral antigen and RNA and release of infectious virions were observed during persistent HuCV-OC43 infections ( approximately 130 days of culture) of U-87 MG, U-373 MG, MO3.13, and H4 cell lines. Nucleotide sequences of RNA encoding the putatively hypervariable viral S1 gene fragment obtained after 130 days of culture were compared to that of initial virus input. Point mutations leading to amino acid changes were observed in all persistently infected cell lines. Moreover, an in-frame deletion was also observed in persistently infected H4 cells. Some point mutations were observed in some molecular clones but not all, suggesting evolution of the viral population and the emergence of viral quasispecies during persistent infection of H4, U-87 MG, and MO3.13 cell lines. These results are consistent with the potential persistence of HuCV-OC43 in cells of the human nervous system, accompanied by the production of infectious virions and molecular variation of viral genomic RNA.  (+info)

Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. (4/471)

We have characterized the hemagglutinin-esterase (HE) of puffinosis virus (PV), a coronavirus closely related to mouse hepatitis virus (MHV). Analysis of the cloned gene revealed approximately 85% sequence identity to HE proteins of MHV and approximately 60% identity to the corresponding esterase of bovine coronavirus. The HE protein exhibited acetylesterase activity with synthetic substrates p-nitrophenyl acetate, alpha-naphthyl acetate, and 4-methylumbelliferyl acetate. In contrast to other viral esterases, no activity was detectable with natural substrates containing 9-O-acetylated sialic acids. Furthermore, PV esterase was unable to remove influenza C virus receptors from human erythrocytes, indicating a substrate specificity different from HEs of influenza C virus and bovine coronavirus. Solid-phase binding assays revealed that purified PV was unable to bind to sialic acid-containing glycoconjugates like bovine submaxillary mucin, mouse alpha1 macroglobulin or bovine brain extract. Because of the close relationship to MHV, possible implications on the substrate specificity of MHV esterases are suggested.  (+info)

Production, characterization, and uses of monoclonal antibodies against recombinant nucleoprotein of elk coronavirus. (5/471)

This is the first report of the production of monoclonal antibodies against elk coronavirus. The nucleoprotein gene of elk coronavirus was amplified by PCR and was cloned and expressed in a prokaryotic expression vector. Recombinant nucleocapsid protein was used to immunize mice for the production of hybridomas. Twelve hybridomas that produced monoclonal antibodies against the nucleocapsid protein of elk coronavirus were selected by an indirect fluorescent-antibody test, an enzyme-linked immunosorbent assay, and a Western blot assay. Ten of the monoclonal antibodies were of the immunoglobulin G1 (IgG1) isotype, one was IgG2a, and one was IgM. All had kappa light chains. By immunohistochemistry four monoclonal antibodies detected bovine coronavirus and elk coronavirus in formalin-fixed intestinal tissues. Antinucleoprotein monoclonal antibodies were found to be better at ruminant coronavirus detection than the anti-spike protein monoclonal antibodies. Because nucleoprotein is a more abundant antigen than spike protein in infected cells, this was not an unexpected finding.  (+info)

A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold . (6/471)

A cysteine proteinase, papain-like proteinase (PL1pro), of the human coronavirus 229E (HCoV) regulates the expression of the replicase polyproteins, pp1a and ppa1ab, by cleavage between Gly111 and Asn112, far upstream of its own catalytic residue Cys1054. In this report, using bioinformatics tools, we predict that, unlike its distant cellular homologues, HCoV PL1pro and its coronaviral relatives have a poorly conserved Zn2+ finger connecting the left and right hand domains of a papain-like fold. Optical emission spectrometry has been used to confirm the presence of Zn2+ in a purified and proteolytically active form of the HCoV PL1pro fused with the Escherichia coli maltose-binding protein. In denaturation/renaturation experiments using the recombinant protein, its activity was shown to be strongly dependent upon Zn2+, which could be partly substituted by Co2+ during renaturation. The reconstituted, Zn2+-containing PL1pro was not sensitive to 1,10-phenanthroline, and the Zn2+-depleted protein was not reactivated by adding Zn2+ after renaturation. Consistent with the proposed essential structural role of Zn2+, PL1pro was selectively inactivated by mutations in the Zn2+ finger, including replacements of any of four conserved Cys residues predicted to co-ordinate Zn2+. The unique domain organization of HCoV PL1pro provides a potential framework for regulatory processes and may be indicative of a nonproteolytic activity of this enzyme.  (+info)

Evaluation of the baculovirus-expressed S glycoprotein of transmissible gastroenteritis virus (TGEV) as antigen in a competition ELISA to differentiate porcine respiratory coronavirus from TGEV antibodies in pigs. (7/471)

The spike (S) glycoprotein of the Miller strain of transmissible gastroenteritis virus (TGEV) was recently cloned and expressed in baculovirus. The recombinant S protein was used as the coating antigen in a competition (blocking) enzyme-linked immunosorbent assay (ELISA) in combination with monoclonal antibodies to the S protein epitope A (conserved on TGEV and porcine respiratory coronavirus [PRCV]) or epitope D (present on TGEV only) to differentiate PRCV- from TGEV-induced antibodies. One set (set A) of 125 serum samples were collected at different times after inoculation of caesarean-derived, colostrum-deprived (n = 52) and conventional young pigs (n = 73) with 1 of the 2 porcine coronaviruses or uninoculated negative controls (TGEV/PRCV/negative = 75/30/20). A second set (set B) of 63 serum samples originated from adult sows inoculated with PRCV and the recombinant TGEV S protein or with mock-protein control and then exposed to virulent TGEV after challenge of their litters. Sera from set A were used to assess the accuracy indicators (sensitivity, specificity, accuracy) of the fixed-cell blocking ELISA, which uses swine testicular cells infected with the M6 strain of TGEV as the antigen source (ELISA 1) and the newly developed ELISA based on the recombinant S protein as antigen (ELISA 2). The sera from set B (adults) were tested for comparison. The plaque reduction virus neutralization test was used as a confirmatory test for the presence of antibodies to TGEV/PRCV in the test sera. The accuracy indicators for both ELISAs suggest that differential diagnosis can be of practical use at least 3 weeks after inoculation by testing the dual (acute/convalescent) samples from each individual in conjunction with another confirmatory (virus neutralization) antibody assay to provide valid and complete differentiation information. Moreover, whereas ELISA 1 had 10-20% false positive results to epitope D for PRCV-infected pigs (set A samples), no false-positive results to epitope D occurred using ELISA 2, indicating its greater specificity. The progression of seroresponses to the TGEV S protein epitopes A or D, as measured by the 2 ELISAs, was similar for both sets (A and B) of samples. Differentiation between TGEV and PRCV antibodies (based on seroresponses to epitope D) was consistently measured after the third week of inoculation.  (+info)

Development of an antigen spot test for detection of coronavirus in bovine fecal samples. (8/471)

We have developed a rapid and sensitive microimmunodot blot assay, the antigen spot test (AST), for the detection of bovine coronavirus (BCV) antigen from neonatal calf fecal samples. The AST procedure can be completed in 3.5 h, whereas the previously reported immunodot blot assays require 10 to 12 h. Ninety-six samples can be tested per membrane, and 10 membranes (960 samples) may be processed by a single technologist in 1 working day. The effects of detergents, oxidizing chemicals, chaotropic agents, and enzyme substrates in improving the sensitivity and signal-to-noise ratio of the AST were studied. Finally, the sensitivity and specificity of AST for the detection of BCV antigen were compared to those of a sandwich enzyme-linked immunosorbant assay (ELISA) and a hemagglutination assay (HA). Of 347 field samples tested by all three methods, 94.2% were positive by AST, 91.4% were positive by ELISA, and 86.7% were positive by HA. The sensitivity of the AST was determined to be 100% compared to the results of the ELISA reference method. The specificity of the AST was 67%, which reflects a lower limit of detection of 10(4) viral particles per ml in a 10% fecal suspension.  (+info)

Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
Author affiliations: King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia (B.M. Alraddadi, H.S. Al-Salmi, H.H. Al-Turkistani, S.S. Al-Rehily, H.A. Alserehi, G.Y. Wali, A.N. Alshukairi); Ministry of Health, Jeddah (B.M. Alraddadi, E.I. Azhar, T.A. Madani); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Jacobs-Slifka, R.B. Slayton, C.F. Estivariz, A.I. Geller, L. Haynes, D.L. Swerdlow, J.A. Jernigan); King Abdulaziz University, Jeddah (E.I. Azhar, T.A. Madani) ...
Background: Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV. Methods: We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016. Results: Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one Plasmodium falciparum malaria. Microbiological analysis identified Rhinovirus (27
Detection of human cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection internationally is a global public health concern. Rigorous risk assessment is particularly challenging in a context where surveillance may be subject to under-ascertainment and a selection bias towards more severe cases. We would like to assess whether the virus is capable of causing widespread human epidemics, and whether self-sustaining transmission is already under way. Here we review possible transmission scenarios for MERS-CoV and their implications for risk assessment and control. We discuss how existing data, future investigations and analyses may help in reducing uncertainty and refining the public health risk assessment and present analytical approaches that allow robust assessment of epidemiological characteristics, even from partial and biased surveillance data. Finally, we urge that adequate data be collected on future cases to permit rigorous assessment of the transmission characteristics and
Between 12 and 16 October 2014, the National IHR Focal Point for the Kingdom of Saudi Arabia (KSA) notified WHO of 5 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths.
In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...
Between 13 and 14 March 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. One of these reported cases is linked to the MERS-CoV outbreak currently occurring in a hospital in Buraidah city.
Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to occur. In this study, we present two nucleic acid visualization assays that target the MERS-CoV UpE and N genes as a p
Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic ...
Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…
During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV) was isolated from the sputum of a patient with acute pneumonia and renal failure (1, 2). The isolate was provisionally called human coronavirus Erasmus Medical Center (EMC) (3). Shortly thereafter, in September 2012, the same type of virus, named human coronavirus England 1, was recovered from a patient with severe respiratory illness who had been transferred from the Gulf region of the Middle East to London, United Kingdom (4) (GenBank accession no. KC164505.2). The onset of the new disease was traced back to an even earlier time point. Already in April 2012, a cluster of pneumonia cases in health care workers had occurred in an intensive care unit of a hospital in Zarqa, Jordan (5). Two persons died, both of whom were confirmed to have been infected with the novel coronavirus through a retrospective analysis of stored samples (6). These findings met with considerable concern. Although the number of ...
TY - JOUR. T1 - Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards. AU - Kim, Sung Han. AU - Chang, So Young. AU - Sung, Minki. AU - Park, Ji Hoon. AU - Kim, Hong Bin. AU - Lee, Heeyoung. AU - Choi, Jae Phil. AU - Choi, Won Suk. AU - Min, Ji Young. N1 - Funding Information: Financial support. This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health &Welfare, Republic of Korea (grant number HI15C2774). This work was also supported by the National Research Foundation of Korea (NRF grant number 2014K1A4A7A01074646) funded by the Korea government and by the Gyeonggi Institute of Science & Technology Promotion Middle East respiratory syndrome grant funded by Gyeonggi-do. Publisher Copyright: © 2016 The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. ...
Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory disease and systemic dysfunction that may eventually lead to the death of the patients. After MERS-CoV was first diagnosed in the South Korea, in May 2015, it affected 186 individuals and claimed 37 lives in short span of time (case fatality rate = 19.9%). Compared to MERS-CoV in the Middle East, MERS-CoV in South Korea appeared to be more transmissible, and induced multiple human-to-human transmission. These knowledge gaps caused the failure of early prevention, and disseminated MERS-CoV brought out a great loss of lives and economy. The MERS-CoV outbreak revealed the potential weakness of public health system in South Korea, and promoted the reestablishment of preventive strategies for imported infectious diseases. In these regards, we analyzed the potential for additional import of re-emerged and emerging infectious diseases, such as dengue fever, malaria, chikungunya fever and hepatitis A, from Africa ...
Clinicians, laboratories and public health practitioners should be aware that many Muslims from Australia will travel to Saudi Arabia in October to undertake the Hajj between 13 and 18 October, and may travel at other times to undertake the Umrah. Health professionals should be aware of the possibility of cases in travellers returning from the Hajj which ends on 18 October 2013.. The Saudi Ministry of Health recommends that elderly people and those with chronic diseases such as heart disease, kidney disease, respiratory disease and diabetes, as well as patients with congenital and acquired immune deficiency diseases, cancer patients, pregnant women and children, defer travel to Saudi Arabia for the Umrah and Hajj this year.. WHO advises that that pre-existing major medical conditions (e.g. chronic diseases such as diabetes or chronic bronchitis, immunodeficiency) can increase the likelihood of medical problems, including MERS-CoV infection, during travel; thus, pilgrims should consult their ...
TY - JOUR. T1 - Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. AU - Josset, Laurence. AU - Menachery, Vineet D.. AU - Gralinski, Lisa E.. AU - Agnihothram, Sudhakar. AU - Sova, Pavel. AU - Carter, Victoria S.. AU - Yount, Boyd L.. AU - Graham, Rachel L.. AU - Baric, Ralph S.. AU - Katzea, Michael G.. PY - 2013. Y1 - 2013. N2 - A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused by SARS coronavirus (SARS-CoV). Although derived from the CoV family, the two viruses are genetically distinct and do not use the same receptor. Here, we investigated whether HCoV-EMC and SARS-CoV induce similar or distinct host responses after infection of a human lung epithelial cell line. HCoV-EMC was able to replicate as efficiently as SARS-CoV in Calu-3 cells and similarly induced minimal ...
On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.
Rapid-response platforms are needed to control newly emerging virus pathogens. MERS-CoV likely emerged in the Middle East from exotic animals, perhaps bats, although the exact timing and origins of this pathogen in human populations remains unclear and is under study. MERS-CoV has caused 54 deaths at the time of writing (∼50% mortality), including documented instances of human-to-human transmission (3, 8). Therefore, the epidemic potential of MERS-CoV is high and its biology, life cycle, gene function, and pathogenic mechanisms clearly warrant additional study.. Developing full-length infectious cDNAs of emerging RNA viruses is assisted by the availability of high-throughput sequencing, gene synthesis, and the use of class II/IIS restriction endonucleases that allow seamless assembly of consensus synthetic cDNA fragments into full-length infectious cDNAs. In this instance, we synthesized a molecular clone from the published sequence, assembled full-length genomes, and isolated recombinant ...
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the
What are coronaviruses?. Coronaviruses are a large family of viruses that can infect humans or animals. Sometimes an animal coronavirus can change so that it can infect people and become a human coronavirus. There are seven known types of human coronaviruses. Four types (229E, NL63, OC43, and KHU1) are common and cause mild to moderate respiratory infections, like the common cold. Two types, Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV), can cause severe respiratory infections. The seventh type (SARS-CoV-2) is the newest coronavirus. It first emerged in the Wuhan Province in China in December 2019. The infectious respiratory disease caused by this virus was named Coronavirus Disease 2019, or more commonly COVID-19.. Who gets coronavirus infections?. Most people become infected with coronaviruses that cause the common cold at some point during their lives. These infections often occur in the fall or winter.. The initial ...
WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR Focal Point (NFP) of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 year-old...
WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...
TravelHealthPro is the website comprising the travel health resources of the National Travel Health Network and Centre (NaTHNaC).
We use cookies to ensure you get the best experience on our website. By continuing, you are agreeing to our use of cookies. To find out more, please click this link.. ...
Discussion. The novel coronavirus is a member of the β coronavirus type, with humans as the host. Since the first human coronavirus (HCoV) was isolated from the nasal secretions of patients with the common cold in 1965, six different strains of CoV are known to infect humans. These CoV strains include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the common cold viruses in individuals with strong immunity (such as 229E, OC43, NL63, and HKU1).1 This novel coronavirus, COVID-19, has more than 85% homology with the previously detected bat coronavirus (a SARS-related coronavirus species, that is, SARS coronavirus). However, there are clear differences in the genetic characteristics of COVID-19 compared with SARS-CoV and MERS-CoV.5. Through observation of the current global epidemic situation, we can demonstrate the infectivity and pathogenicity of COVID-19. To the treatment of COVID-19, the main treatment is antiviral therapy, ...
Corona in Gujarat , Corona update in Gujarat , corona virus test , coronavirus , coronavirus cases , coronavirus cases in india , coronavirus epidemic , coronavirus in india , coronavirus in india state wise , coronavirus india , coronavirus india news , coronavirus latest news , CoronaVirus News , coronavirus symptoms , coronavirus tips , coronavirus update , coronavirus update in india , coronavirus update india , covid 19 , india coronavirus cases , latest on coronavirus in india , light diyas , Lockdown , lockdown in Gujarat , Singapore , Singapore lockdown,coronavirus , coronavirus cases , coronavirus cases in india , coronavirus in india , coronavirus in india state wise , coronavirus india , coronavirus india news , coronavirus latest news , CoronaVirus News , coronavirus symptoms , coronavirus tips , coronavirus update , coronavirus update in india , coronavirus update india , gujarat coronavirus , Gujarat coronavirus death , Gujarat coronavirus death toll , india coronavirus cases , ...
Viral respiratory system diseases such as for example severe acute respiratory system symptoms (SARS) and Middle East respiratory system symptoms (MERS) always pose a serious threat to the people. using the same sea food market. Together with the Spring Event exodus, an outbreak appeared unavoidable. This problem attracted the interest of the Chinese language Middle for Disease Control and Avoidance (CDC), who instantly released a crisis response. The World Health Organization (WHO) also responded promptly and declared the outbreak a public health emergency of international concern (PHEIC). The causative agent of the unidentified pneumonia has been confirmed as a novel coronavirus by sequencing and aetiological investigations by several independent laboratories in China. Following the isolation of the new coronavirus, it was found to be distinct both from Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) [1,2]. Coronaviruses are ...
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV. We also determined high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody. The structures reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they define four conformational states of the trimer wherein each receptor-binding domain is either ...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
Background Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS) outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods. Methods The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods. Results The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of
1. Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N. Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis. BMC Public Health. 2016 Nov 29;16(1):1203.. 2. Dinh L, Chowell G, Mizumoto K, Nishiura H. Estimating the subcritical transmissibility of the Zika outbreak in the State of Florida, USA, 2016. Theor Biol Med Model. 2016 Nov 9;13(1):20.. 3. Nah K, Otsuki S, Chowell G, Nishiura H. Predicting the international spread of Middle East respiratory syndrome (MERS). BMC Infect Dis. 2016 Jul 22;16:356. doi: 10.1186/s12879-016-1675-z.. 4. Otsuki S, Nishiura H. Reduced Risk of Importing Ebola Virus Disease because of Travel Restrictions in 2014: A Retrospective Epidemiological Modeling Study. PLoS One. 2016 Sep 22;11(9):e0163418. doi: 10.1371/journal.pone.0163418.. 5. Nishiura H, Mizumoto K, Rock KS, Yasuda Y, Kinoshita R, Miyamatsu Y. A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection. ...
A collaborative team from The University of Texas Medical Branch at Galveston, Saudi Arabia and Canada developed a potent and safe vaccine that protects against the deadly Middle East respiratory syndrome, or MERS.
Comments, concepts and statistics about Healthcare worker infected with Middle East respiratory syndrome during cardiopulmonary resuscitation in Korea, 2015.
Background Viral load kinetics and duration of viral shedding are important determinants for disease transmission. We aimed to characterise viral load dynamics, duration of viral RNA shedding, and viable virus shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids, and to compare SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) viral dynamics. Methods In this systematic review and meta-analysis, we searched databases, including MEDLINE, Embase, Europe PubMed Central, medRxiv, and bioRxiv, and the grey literature, for research articles published between Jan 1, 2003, and June 6, 2020. We included case series (with five or more participants), cohort studies, and randomised controlled trials that reported SARS-CoV-2, SARS-CoV, or MERS-CoV infection, and reported viral load kinetics, duration of viral shedding, or viable virus. Two authors independently extracted data from published studies, or contacted authors to request ...
The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...
Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its family tree.. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...
MERS is caused by a virus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which belongs to the Coronavirus family of viruses. MERS Virus belongs to the genus Betacoronavirus. Coronavirus family of viruses includes viruses that usually cause respiratory tract illnesses like the common cold in human beings, and also, these viruses cause a number of diseases in animals. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) causes Severe Acute Respiratory Syndrome (SARS).. Continue reading → ...
The global novel coronavirus (COVID‐19 or 2019‐CoV) issue has posed significant threats to international human health and the economy, human are fighting this novel coronavirus together. Omega-3 polyunsaturated fatty acids and antiviral treatments should be useful in fighting novel coronavirus (COVID‐19).
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with …
Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein-receptor interacting residues. In conclusion, we suggest that a
Acknowledgment: The authors thank the members of the Department of Clinical Nursing and the Infection Prevention and Control Program, King Abdulaziz Medical City, Riyadh, Saudi Arabia, for their assistance. They also thank the following persons: From the King Saud bin Abdulaziz University for Health Sciences, Riyadh: Sameera Johani, MD, Division of Microbiology, Pathology & Laboratory Medicine; Abdullah Ghamdi, MD, Department of Cardiac Sciences; Ghassan A. Al-Ghamdi, MD, Intensive Care Department and Assistant Professor, College of Medicine; Saqib I. Dara, MD, Intensive Care Department; Raed A. Hijazi, MD, Emergency Medicine; Olivia A. Trinidad, RRT, Edgardo Tabhan, RRT, and Charina Olay, RRT, all Respiratory Therapist I, Respiratory Services. From the King Abdulaziz Hospital, Al-Ahsa: Yusri Taha, MD, and Mohammed Ayman El Gammal, MD, Infectious Diseases, Department of Medicine and Abdulsalam Al-Aithan, MD, Pulmonary & Intensive Care Medicine. From the Imam Abdulrahman Bin Faisal Hospital, ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Dr Shikha Sharma. Coronavirus disease (COVID-19) is an unforgettable word in 2020. World health organization has declared COVID-19 as pandemic and according to the Worldometer site, it has affected 212 countries and territories and has caused approximately 2.8 lakhs deaths so far. According to the various published scientific evidences COVID-19 is an infectious disease caused by new coronavirus that can lead to lung dysfunction. There are 7 coronaviruses that are known to cause disease in humans and among these 3 can cause the severe respiratory infection. These are severe acute respiratory syndrome coronavirus (SARS-CoV) identified in 2002 in China, Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012 in Saudi Arabia and severe acute respiratory syndrome coronavirus2 (SARS-CoV2) commonly called COVID-19 identified in late 2019 in Wuhan, China. SARS-CoV, MERS-CoV and COVID-19 are closely related but COVID-19 spread more quickly than the other two. Over 8000 people from 29 ...
Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child with bronchiolitis in the Netherlands. Infection with the virus has been confirmed worldwide, and has an association with many common symptoms and diseases. Associated diseases include mild to moderate upper respiratory tract infections, severe lower respiratory tract infection, croup and bronchiolitis. The virus is found primarily in young children, the elderly, and immunocompromised patients with acute respiratory illness. It also has a seasonal association in temperate climates. A study performed in Amsterdam estimated the presence of HCoV-NL63 in approximately 4.7% of common respiratory illnesses. Further studies confirmed that the virus is not an emerging virus, but rather one that continually circulates the human population. The first cases of the infection with HCoV-NL63 were found in young children with severe lower respiratory tract infections admitted to ...
Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which do not target the underlying virus infection. The identification of specific inhibitors of coronaviruses or knowledge about how coronaviruses interact with the innate immune system could provide new avenues for developing therapeutics. I investigated the replication of human coronavirus NL63 (HCoV-NL63) in primary human airway epithelial cultures and characterized the activity of the viral papain-like protease 2 (PLP2) domain. Using quantitative real time PCR and imaging techniques I showed that HCoV-NL63
ARTICLE:. J Dyall et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrobial Agents and Chemotherapy DOI: 10.1128/AAC.03036-14 (2014).. WHO:. NIAID Director Anthony S. Fauci., M.D., is available to comment on this research. Co-author Lisa Hensley, Ph.D., associate director for science, NIAID Integrated Research Facility, is also available to discuss the findings.. CONTACT:. To schedule interviews, please contact Anne A. Oplinger, (301) 402-1663, [email protected] For additional information about research on MERS and other coronaviruses by NIAID scientists and grantees, see: http://www.niaid.nih.gov/topics/coronavirus/Pages/default.aspx.. The study was funded, in part, by NIAID grant AI095569.. NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating ...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.
According to the abstract, Saudi Arabia and United States researchers write:. Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset.. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of ...
Title: Two New Cases of MERS Coronavirus reported in Saudi Arabia.. Subject: Middle East Respiratory Syndrome Coronavirus in Saudi Arabia, daily update.. Source: Saudi Arabia Ministry of Health, full page: (LINK).. Code: [ ]. _____. MOH: 2 New Confirmed Coronavirus Cases Recorded. ___ New Cases Reported: [Sex, Age, Citizenship, Resident in, Health Status, Note ...
Understanding Middle East respiratory syndrome coronavirus (MERS-CoV) transmission in dromedary camels is important, as they consitute a source of zoonotic infection to humans. To identify risk factors for MERS-CoV infection in camels bred in diverse conditions in Burkina Faso, Ethiopia and Morocco, blood samples and nasal swabs were sampled in February-March 2015. A relatively high MERS-CoV RNA rate was detected in Ethiopia (up to 15.7%; 95% confidence interval (CI): 8.2-28.0), followed by Burkina Faso (up to 12.2%; 95% CI: 7-20.4) and Morocco (up to 7.6%; 95% CI: 1.9-26.1). The RNA detection rate was higher in camels bred for milk or meat than in camels for transport (p = 0.01) as well as in younger camels (p = 0.06). High seropositivity rates (up to 100%; 95% CI: 100-100 and 99.4%; 95% CI: 95.4-99.9) were found in Morocco and Ethiopia, followed by Burkina Faso (up to 84.6%; 95% CI: 77.2-89.9). Seropositivity rates were higher in large/medium herds (≥51 camels) than small herds (p = 0.061), in
The US FDA approved niclosamide, an oral anthelminthic drug, in 1982 for human use. It is also included in the essential medicines list of WHO. TFF used this drug to cure several million. It is recently repurposed to cure several viral infections that include SARS-CoV (severe acute respiratory syndrome coronavirus), Zika Virus, and MERS-CoV (Middle East respiratory syndrome coronavirus).. According to clinical trials, niclosamide has the potential to treat SARS-CoV-2. Low oral bioavailability and low absorption rate of niclosamide pose a challenge to develop it as an anti-viral therapy.. ...
The Saudi Arabia Ministry of Health (MOH) has reported a new case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in a citizen of Riyadh,
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related vira …
Novel coronavirus disease 2019 (2019-nCoV) is a global pandemic which threatens all over the world. The first cases were seen in Wuhan, China, in December 2019 (Guo et al. 2020; Chen et al. 2020). It has spread rapidly, and now, there are more than 2.3 million reported cases and 160,000 deaths worldwide. 2019-nCoV may cause multi-system infections especially respiratory infections such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) (Guo et al. 2020; Chen et al. 2020; Sanders et al. 2020). In some cases, infections may be mild (only cough or fever, etc.); however, in some cases, infections may be severe (acute respiratory failure with diffuse pneumonia). In severe cases, there is an exaggerated immune response with low peripheral lymphocyte levels and high cytokine levels. This mechanism of pathogenesis may be responsible for the multiple organ failures (Cao et al. 2019; Lin et al. 2020). In this early stage of the 2019-nCoV, the infection may be treated ...
Health officials say the 68-year-old man was in Bahrain on work-related crop cultivation business from April 18 to May 3. He traveled through Qatars airport on May 4.. One week after arriving back in South Korea he exhibited symptoms of fever and cough and was initially treated on an outpatient basis.. A couple of days later he was hospitalized and was confirmed positive for the Middle East Respiratory Syndrome coronavirus (MERS-CoV).. Health officials say the patient is in stable condition. In addition, they note that family contacts are being watched.. According to the World Health Organization (WHO), they have been notified of 1118 laboratory-confirmed cases of infection with MERS-CoV, including at least 423 related deaths as of May 18.. MERS was first reported in Saudi Arabia in 2012.. ...
The Ministry of Health (MOH} of the Kingdom of Cambodia and the Worl.d Health Organization (WHO) wish to inform the public that currently, there is no case related to the Middle East Respiratory Syndrome Corona virus (MERS-CoV) infections and the Ebola Virus Disease have been detected in Cambodia, so far.. 1. MERS-CoV is a novel coronavirus that causes acute respiratory illness in infected patients. The virus was first reported by the WHO in 2012, and thus far all cases worldwide remained associated with the Arabian Peninsula. The risk of a MERS-CoV outbreak in Cambodia remains low as sustained human-to-human transmission of the virus has not been reported.. The MOHs Department of Communicable Disease Control has, since 2013, been conducting MERS-CoV dissemination workshops in close collaboration with religious leaders, for communities at risk, that cover actions that should be undertaken by pilgrims betore, during and after their Hajj and Umrah pilgrhnages to the Middle East. There is ...
A member of the volunteer group Wuhan Emergency Team, installs a national flag on the car in Wuhan, central Chinas Hubei Province, Feb. 29, 2020. (Xinhua/Xiao Yijiu). The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. BEIJING, March 2 (Xinhua) -- China is in a nationwide mobilization to curb the spread of the novel coronavirus. Here are the latest developments:. -- Chinas daily new confirmed and suspected cases of the novel coronavirus disease (COVID-19) have seen an overall downward trend for two weeks. The number of newly discharged patients nationwide continues to show an upward trend, fluctuating around 3,000 in recent days.. The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. -- A team of doctors in a hospital in central Chinas Hunan Province successfully 3D printed the model of the nidus of a patient infected with the ...
novel coronavirus pneumonia novel coronavirus pneumonia data released by Canadian provinces were released at 18 PM August 13th. Canada has identified 390 new cases of new crown pneumonia in the past 24 hours, 121234 cases of cumulative cases, 6 cases of new deaths and 9012 cases of cumulative deaths. < / P > < p > of the newly confirmed cases, 76 cases were newly diagnosed in Alberta, 78 cases in British Columbia, 104 cases in Quebec, 78 cases in Ontario, 25 cases in Manitoba, 27 cases in Saskatchewan and 2 cases in New Brunswick. Six new deaths on the day were all from Quebec province. (head station reporter Zhang SEN). ...
The official name for the disease that is causing the 2019 novel coronavirus outbreak is COVID-19. The novel coronavirus that causes the disease is known as 2019-nCoV.. International and national health organizations and local health departments are monitoring the COVID-19 outbreak. Due to the situations rapidly changing nature, WOEMA recommends using the following websites to obtain the most current information:. American College of Occupational and Environmental Medicine: ACOEM ...
Have you ever heard about an emerging disease on a TV news program or in a newspaper and wanted to know more about it? Then you may be interested in the Disease Outbreak News (DON), published as needed by the World Health Organization, or WHO, a United Nations agency headquartered in Geneva, Switzerland. The web address is www.who.int/csr/don/en/ .. The DON reports the facts regarding where new disease outbreaks are occurring around the world and how many cases are involved. Most of the recent reports concern Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. MERS-CoV cases are showing up in Saudi Arabia, Qatar and the United Arab Emirates, with a few cases recently noted in China and South Korea.. While not every ARES member would benefit from these reports, members who are also medical professionals might. Wright-Patterson AFB employees and contractors regularly travel to many of the countries mentioned above, and its just possible that some of these emerging illnesses may someday ...
A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle East. We report the deep genome sequencing of the virus directly from a patients sputum sample. Our high-throughput sequencing yielded a substantial depth of genome sequence assembly and showed the minority viral variants in the specimen. Detailed phylogenetic analysis of the virus genome (England/Qatar/2012) revealed its close relationship to European bat coronaviruses circulating among the bat species of the Vespertilionidae family. Molecular clock analysis showed that the 2 human infections of this betacoronavirus in June 2012 (EMC/2012) and September 2012 (England/Qatar/2012) share a common virus ancestor most likely considerably before early 2012, suggesting the human diversity is the result of multiple zoonotic events.
Thanks to FluTrackers for picking up this report from the Saudi Gazette: Ministry accused of falsifying information on MERS cases. It confirms the Arabic reports mentioned here yesterday. A Saudi poet who contracted the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)...
TY - JOUR. T1 - History and recent advances in coronavirus discovery. AU - Kahn, Jeffrey. AU - McIntosh, Kenneth. PY - 2005/11. Y1 - 2005/11. N2 - Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history ...
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 September-5 October 2019 and includes updates on Ebola virus disease, extensively drug-resistant Klebsiella pneumoniae, mass gathering monitoring (Japan, Rugby World Cup 2019), Middle East respiratory syndrome coronavirus, Plasmodium cynomolgi infection, poliomyelitis, West Nile virus, and yellow fever. ...
Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94]. On 15 September 2012, Dr. Zakis findings were posted on ...
Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94] On 15 September 2012, Dr. Zakis findings were posted on ...
As this global concern grows by the minute so should your concern to take action into protecting yourself and your loved ones from this worldwide threat. According to the most recently published article by JAMA (An International peer-reviewed medical journal association), the Coronavirus disease 2019 (COVID-19) is a respiratory illness that results from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Furthermore, the article shares that following initial reports of disease outbreak in China, COVID-19 has spread worldwide with cases identified in at least 67 countries across 6 continents. So if this is an acute respiratory illness why is the world-wide population running out of toilet paper? Ok, I must admit this is funny but not really!. What is coronavirus disease 2019?. According to the CDC, the Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first ...
Till the date, the deadly novel coronavirus has infected 210 countries and territories around the world. The world has reported 3,074,553 positive cases, 211,773 deaths so far. Doctors and researchers across the world are trying to develop drugs and vaccines to prevent the deadly coronavirus. Under such circumstances, hospitals in New York have been quietly testing a common over-the-counter drug as a probable cure for coronavirus (COVID-19) after doctors in China found that elderly survivors were consuming it.. Have you ever heard of a drug named, famotidine? This medicine is especially used for peptic ulcers and GERD (Gastroesophageal Reflux Disease) and sold in oral form under brand name Pepcid. Famotidine is the active compound in the over-the-counter (OTC) heartburn drug Pepcid. It is being examined to treat hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for causing the coronavirus disease 2019 (COVID-19), by Northwell Health in ...
MERS should be considered when a severe respiratory illness occurs in the 2 weeks following residence in or travel to the Middle East or areas of outbreak, and/or close contact with infected individuals. The majority of cases are the result of human-to-human transmission, with peaks of confirmed ...
Coronavirus in Texas 3/27: U.S. House approves coronavirus spending bill By Texas Tribune Staff, The Texas Tribune March 27, 2020 Coronavirus in Texas 3/27: U.S. House approves coronavirus spending bill was first published by The Texas Tribune, a nonprofit, nonpartisan media organization that informs Texans - and engages with them - about public policy, politics, government and statewide issues. Fridays biggest developments Abbott deploys National Guard to help with testing sites, healthcare Six Lubbock nursing home residents test positive for COVID-19 Latest report for Texas: 1,731 COVID-19 cases, 23 deaths U.S. House approves coronavirus spending bill Texas eases child care regulations to help low-income parents during pandemic [6:41 p.m.] As part of an ongoing response to the economic hit Texans face due to the new coronavirus, Gov. Greg Abbott agreed to ease regulations for child care centers serving low-income children through state subsidies. Now, child care providers will receive ...
Youve likely heard about the 2019 Novel Coronavirus (2019-nCoV) that originated in China late last year. The first case in the United States was reported at Providence Regional Medical Center- Everett last week. Coronaviruses are the cause of roughly 10% of all common colds.. This particular strain, however, is more dangerous than a common cold. Symptoms include fever, cough, and shortness of breath. Symptoms can appear in as few as two days or as long as 14 days after exposure. While we are still analyzing exactly how this virus is transmitted, it appears that person to person spread happens mainly via respiratory droplets produced when an infected person coughs or sneezes, similar to how influenza is transmitted.. If you have travelled to, or have been in close contact with, someone who has travelled to China and you develop fever, cough, or shortness of breath, call 911 or your doctors office. Before going to the doctors office or hospital please call ahead and tell them that you may have ...
The U.S. Centers for Disease Control and Prevention confirms the first U.S. case of the newly-emerging Middle East Respiratory Virus or MERS within U.S. borders. Jillian Kitchener reports.
Sigma-Aldrich offers abstracts and full-text articles by [Shamsudeen F Fagbo, Leila Skakni, Daniel K W Chu, Musa A Garbati, Mercy Joseph, Malik Peiris, Ahmed M Hakawi].
Bats, the source of so many viruses, could be the origin of Wuhan coronavirus, say experts - CNN. Deadly coronavirus may have originated in bats: researchers - Weve detected unusual activity from your computer network Up Next Close Rob Gronkowski opens up about everything.. Furthermore, genes for different immune cell subsets, T-cell receptors TCRs , cytokines and chemokines, and interferon-related genes were detected, while genes encoding for natural killer NK cell receptors were largely absent. Meyerholz D. DeGroote fellowship awarded to A. Bats are known to harbor a wide range of viruses including many that are highly pathogenic in humans. The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. In the study, published today Jan. In , a novel alphacoronavirus was identified in an outbreak of respiratory disease in alpacas in the US, which is geographically separated from the bat species that harbor ...
Carlos del Rio executive associate dean for Emory University School of Medicine at Grady Health System, published important information for clinicians in JAMA detailing the 2019 novel coronavirus pandemic, saying that the outbreak is doubling in case size every 6.4 days.
WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...
WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...
We are monitoring closely the Covid-19 (Novel Coronavirus) situation and our task force is continually assessing and responding to changes.
Gentaur molecular products has all kinds of products like :search , bio-gentaur \ NATtrol Coronavirus NL63_ Stock \ GENNATCOV(NL63)-ST for more molecular products just contact us
By DAVID J. HILL. The World Health Organization on Thursday declared the outbreak of novel coronavirus a global emergency. While that news may stoke some anxiety among members of the UB community, university leaders want to assure students, faculty and staff that proper precautions are being taken to ensure the health and safety of everyone on campus.. At UB, a team of experienced professionals continues to monitor the situation on campus and has been coordinating with its partners in Erie County, New York State and the U.S. Centers for Disease Control and Prevention.. Consistent communication has been key to keeping the campus community apprised of important information on novel coronavirus, including basic tips on how members of campus can monitor their health.. UB created a coronavirus information website, which contains a list of frequently asked questions, a video featuring Susan Snyder, UBs director of student health services, as well as links to advisories from the CDC and the U.S. ...
TUESDAY, April 21, 2020 (HealthDay News) -- An early analysis of antibody testing from Los Angeles County finds a coronavirus infection rate that is up to 55 times the number of confirmed COVID-19 cases.. According to the researchers behind the study, the vast majority of people infected with the new coronavirus may be going without symptoms or have minimal symptoms.. Its one of the first in-depth analyses of local population infection rates conducted in the United States.. Los Angeles Countys population totals more than 10 million. As the research team noted, by early April, there were 7,994 confirmed cases of COVID-19 reported in the county, including 600 COVID-19 deaths. But new findings from the first round of ongoing antibody blood testing of county residents showed that about 4.1% of adults had antibodies to the coronavirus.. Adjusting for any statistical margin of error, that suggests that between 2.8% to 5.6% of the countys adults have antibodies to the coronavirus, which translates ...
Coronaviruslike viruses previously have been identified in feces of diarrheic foals and adult horses (1, 7, 8, 13, 17). In the present study, a coronavirus associated with diarrhea in a young foal was serially propagated in cell culture and partially characterized. The virus was identified as a coronavirus based on (i) virion size and morphology, (ii) antigenic relatedness to BCV and HEV as determined by serological procedures, and (iii) genetic relatedness to BCV, HCV strain OC43, and MHV as determined by N gene sequence analysis. The virus tentatively is identified as equine coronavirus (ECV) based on the origin of the virus.. The coronavirus N protein has been shown to be highly variable in amino acid composition between the viruses that comprise the three coronavirus antigenic groups but highly conserved within these groups (27, 30). In the present study, a high degree of identity (66.7 to 90.1%) was observed between the N protein sequences of ECV strain NC99 and N protein sequences of group ...
My eyes are killing me…is it coronavirus? If youve found yourself wondering if youve picked up COVID-19 through your eyes, youre not alone. The coronavirus presents with the usual flu symptoms, and pink, irritated eyes with discharge is one of them. Heres what you need to know about the connection between conjunctivitis and coronavirus.. Pink eye can be environmental, viral or bacterial. If you think you have conjunctivitis, or pink eye, there could be several causes. This time of year, you could be reacting to pollen, mold, chemicals and other allergens in the air1. Sometimes bacteria can cause an eye infection flare-up but, by far, the majority of cases of pink eye are caused by viruses. One of these viruses could be coronavirus. But it just as easily could be another culprit.. According to the American Academy of Ophthalmologists, there are cases that show that viruses that cause conjunctivitis were likely transmitted through the air to the eye. It is possible that the coronavirus could ...
Canine coronavirus), Human coronavirus 229E, Human coronavirus NL63, Miniopterus bat coronavirus 1, Miniopterus bat coronavirus ... Bovine Coronavirus, Human coronavirus OC43), Hedgehog coronavirus 1, Human coronavirus HKU1, Middle East respiratory syndrome- ... related coronavirus, Murine coronavirus, Pipistrellus bat coronavirus HKU5, Rousettus bat coronavirus HKU9, Severe acute ... Avian coronavirus, Beluga whale coronavirus SW1 Genus Deltacoronavirus Species: Bulbul coronavirus HKU11, Porcine coronavirus ...
Dr ADDIE website focused research about FIP Coronavirus Site général Coronavirus site général Coronavirus Pictures (CS1 French- ... Feline coronavirus (FCoV) is a positive-stranded RNA virus that infects cats worldwide. It is a coronavirus of the species ... "Feline Coronavirus Type II Strains 79-1683 and 79-1146 Originate from a Double Recombination between Feline Coronavirus Type I ... and porcine transmissible gastroenteritis coronavirus (TGEV). It has two different forms: feline enteric coronavirus (FECV) ...
"Coronavirus Australia - Apps on Google Play". play.google.com. Retrieved 9 April 2020. "Government launches Coronavirus ... Coronavirus Australia was an app released by the Australian Government designed to allow users to access information about the ... "Coronavirus Australia on the App Store". 12 April 2020. Archived from the original on 12 April 2020. Retrieved 12 April 2020. ... "Coronavirus (COVID-19) self-isolation and test status notification". covid-form.service.gov.au. Retrieved 12 April 2020. "App ...
... taken between 2017 and 2018 and found a novel coronavirus. This coronavirus is a species of Canine coronavirus (CCoV) which was ... Known as canine respiratory coronavirus (CRCoV) and found to be similar to strain OC43 of bovine and human coronaviruses, it ... A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus ... Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species ...
The specific name coronavirus refers to the COVID-19 pandemic. The author states that he also named this species in this manner ... Potamophylax coronavirus is a species of caddisfly in the family Limnephilidae. It is endemic to Kosovo. It was named after the ... The river basin habitat of P. coronavirus has been described as a "battlefield between scientists and civil society on one side ... "New species of insect discovered in Kosovo is named after coronavirus , Climate News , Sky News". 2021-12-03. Archived from the ...
The ferret coronavirus is a coronavirus which infects ferrets and is a strain of the species Mink coronavirus 1. The first ... There are two types of ferret coronavirus. These are ferret enteric coronavirus and ferret systemic coronavirus. Murray, Jerry ... April 3, 2020.{{cite web}}: CS1 maint: url-status (link) "Ferret coronavirus taxonomy".{{cite web}}: CS1 maint: url-status ( ... Kiupel, Matti; Maes, Roger K. (2010). "Ferret Coronavirus-Associated Diseases". Veterinary Clinics of North America: Exotic ...
... may refer to: List of deaths from the 2019-20 coronavirus pandemic, a list of notable people 2019-20 ... statistics on the numbers of deaths This disambiguation page lists articles associated with the title Coronavirus deaths. If an ...
Coronavirus'; shot during lockdown". The New Indian Express. 26 May 2020. Retrieved 22 June 2021. "'Coronavirus' Trailer: Ram ... Coronavirus is a 2020 Indian Telugu-language thriller drama film about a family exposed to the virus during the COVID-19 ... "IT'S ABOUT ABUSING GOD" - RAM GOPAL VARMA'S CORONAVIRUS SONG!". Behindwoods. 12 June 2020. Retrieved 13 June 2020. v t e v t e ...
Coronavirus Coronavirus diseases Coronavirus 229E Coronavirus OC43 Coronavirus NL63 Bat SARS-like coronavirus WIV1 Bat-borne ... Novel coronavirus (nCoV) is a provisional name given to coronaviruses of medical significance before a permanent name is ... 2020). "The 2019-2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of ... January 2005). "Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with ...
Anon, "Helsinki to trial coronavirus breathalyser", Yle, June 29, 2020. News desk, "Finland to trial instant coronavirus ... A coronavirus breathalyzer is a diagnostic medical device enabling the user to test with 90% or greater accuracy the presence ... Anon, "New coronavirus test that is eight times faster can help locate asymptomatic carriers", EurekAlert!, April 20, 2020. ... "We are engaged in innovative cooperation with corporations to solve the coronavirus crisis, and we will help firms to use the ...
... , or RCV, is a strain or subspecies of Murine coronavirus that infects rats. The earliest discovered strains of ... Parker's rat coronavirus, or PRC and most other rat coronavirus strains cause respiratory illness. Both SDAV and PRC can cause ... They cannot be distinguished morphologically from other members of the genus Coronavirus. The rat coronavirus is a single- ... "Coronaviruses (RCV and SDAV)". dora.missouri.edu. Retrieved 2020-06-11. Funk CJ, Manzer R, Miura TA, Groshong SD, Ito Y, ...
... are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in ... The first coronavirus disease was discovered in the late 1920s, however, the most recent common ancestor of coronaviruses is ... As of 2021, 45 species are registered as coronaviruses, whilst 11 diseases have been identified, as listed below. Coronaviruses ... "Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination ...
Coronavirus (CoV) Coronaviridae Coronavirus diseases Coronavirus#Outbreaks Chinese virus (disambiguation) This disambiguation ... Chinese coronavirus may refer to: Severe acute respiratory syndrome coronavirus (SARS-CoV), first reported in Foshan, Guangdong ... China; in November 2002 2002-2004 SARS outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first reported in ... page lists articles associated with the title Chinese coronavirus. If an internal link led you here, you may wish to change the ...
... there are also the Lucheng Rn rat coronavirus, China Rattus coronavirus HKU24 and Myodes coronavirus 2JL14, with a large number ... Murine coronavirus is an important pathogen in the laboratory mouse and the laboratory rat. It is the most studied coronavirus ... In contrast, bovine coronavirus, human coronavirus OC43, and others are still sugar receptors, so the spike NTD retains the ... Murine coronavirus is believed to be most closely related to human coronavirus HKU1. These two species, along with ...
... , sometimes called Porcine coronavirus HKU15 (PorCoV HKU15) is a virus first discovered in a surveillance ... "Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene ... Wang, L; Zhang, Y; Byrum, B (2014). "Complete Genome Sequence of Porcine Coronavirus HKU15 Strain IN2847 from the United States ... The virus has been referred to as Porcine coronavirus HKU15, Swine deltacoronavirus and Porcine deltacoronavirus. Porcine ...
... turkey coronavirus, pheasant coronavirus, duck coronavirus, goose coronavirus, pigeon coronavirus) de Wit, J.J. Sjaak; Cook, ... the genus Coronavirus, it was the type species of the group of all known coronaviruses. When two strains of coronavirus IBV ... The strain of avian coronavirus previously known as infectious bronchitis virus (IBV) is the only coronavirus that infects ... The strain of avian coronavirus previously classified as Turkey coronavirus causes gastrointestinal disease in turkeys. IBV is ...
... on Netflix Coronavirus, Explained at IMDb v t e (Articles with short description, Short description is ... Coronavirus, Explained is an American documentary limited series produced by Vox. The series, along with The Mind, Explained ... Jarvey, Natalie (April 25, 2020). "Netflix Unpacks Coronavirus Pandemic With New Season of 'Explained'". hollywoodreporter.com ...
... (BCV or BCoV) is a coronavirus which is a member of the species Betacoronavirus 1. The infecting virus is an ... Fehr, Anthony R.; Perlman, Stanley (2015). "Coronaviruses: An Overview of Their Replication and Pathogenesis". Coronaviruses. ... Bovine Coronavirus, and Human Coronavirus OC43". Journal of Virology. 80 (14): 7270-7274. doi:10.1128/JVI.02675-05. PMC 1489060 ... "Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus ...
... may refer to: SARS-CoV-2 Delta variant, a variant of SARS-CoV-2 virus that causes COVID-19 Deltacoronavirus, ... a grouping of coronavirus species that affects birds and non-human mammals This disambiguation page lists articles associated ... with the title Delta coronavirus. If an internal link led you here, you may wish to change the link to point directly to the ...
Coronaviruses are a group of viruses that cause diseases in mammals and birds. Coronavirus may also refer to: Severe acute ... a disease caused by the coronavirus strain SARS-CoV MERS, a disease caused by the coronavirus strain MERS-CoV Upper respiratory ... respiratory syndrome coronavirus 2 (SARS-CoV-2), a strain that emerged in 2019 Coronavirus disease 2019 (COVID-19), the disease ... Look up coronavirus in Wiktionary, the free dictionary. ... which may be caused by several different coronaviruses This ...
Coronaviruses manipulate the cell cycle of the host cell through various mechanisms. In several coronaviruses, including SARS- ... 2020). "Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States". Emerging ... it is not required for RNA transcription in all coronaviruses. In at least one coronavirus, transmissible gastroenteritis virus ... In many coronaviruses, a population of N protein is localized to the nucleolus, thought to be associated with its effects on ...
... is a species of coronavirus in the genus Gammacoronavirus. "International Committee on Taxonomy of ...
Human coronavirus HKU1 Lee, Paul (2007). Molecular epidemiology of human coronavirus OC43 in Hong Kong (Thesis). The University ... Wikimedia Commons has media related to Human coronavirus OC43. Wikispecies has information related to Human coronavirus OC43. ... "Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus ... The infecting coronavirus is an enveloped, positive-sense, single-stranded RNA virus that enters its host cell by binding to ...
Coronavirus 5′ UTR Coronavirus 3′ UTR pseudoknot Coronavirus 3′ stem-loop II-like motif (s2m) Coronavirus frameshifting ... Coronavirus genomes are positive-sense single-stranded RNA molecules with an untranslated region (UTR) at the 3′ end which is ... Even though a nearby pseudoknot structure, which has been observed in other genera of coronaviruses, is present, its functional ... Yang, Dong; Leibowitz, Julian L. (2015-08-03). "The structure and functions of coronavirus genomic 3′ and 5′ ends". Virus ...
In some coronaviruses, including MERS-CoV, E has been reported to be essential. In others, including mouse coronavirus and SARS ... the intracellular compartment that gives rise to the coronavirus viral envelope. Studies in different coronaviruses have ... In most coronaviruses, E and M are sufficient to form virus-like particles, though SARS-CoV has been reported to depend on N as ... The membrane topology of the E protein has been studied in a number of coronaviruses with inconsistent results; the protein's ...
"Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus". J. Virol ... "Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene ... Bulbul coronavirus HKU11 (Bulbul-CoV HKU11) is a positive-sense single-stranded RNA Deltacoronavirus of avian origin found in ... source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and ...
Within coronavirus lineages, as well as across the four major coronavirus subgroups, the S1 region is less well conserved than ... "Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry". Proceedings of ... "Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus ... Coronaviruses use a very diverse range of receptors; SARS-CoV (which causes SARS) and SARS-CoV-2 (which causes COVID-19) both ...
Coronavirus 5′ UTR Coronavirus 3′ UTR Coronavirus 3′ UTR pseudoknot Coronavirus 3′ stem-loop II-like motif (s2m) Coronavirus ... Other RNA families identified in the coronavirus include the coronavirus frameshifting stimulation element, the coronavirus 3′ ... The Coronavirus packaging signal is a conserved cis-regulatory element found in Betacoronavirus (part of the Coronavirus ... bovine coronavirus (BCoV), and human coronaviruses like HCoV-HKU1 and HCoV-OC43. Notably, this element is absent from the other ...
... is a species of coronavirus in the genus Betacoronavirus. "International Committee on Taxonomy of ...
... may refer to: White House Coronavirus Task Force Inter-Agency Task Force for the Management of Emerging ... to the COVID-19 pandemic in the Philippines This disambiguation page lists articles associated with the title Coronavirus Task ...
https://www.cdc.gov/coronavirus/2019-ncov/sympt oms-testing/symptoms.html. Symptoms of COVID -19. Know the symptoms of COVID-19 ...
Over 2.98M Americans filed for unemployment benefits last week, pushing two-month coronavirus job losses to 36M. Economists ... Get all the latest news on coronavirus and more delivered daily to your inbox. Sign up here. ... as the shutdowns caused by the coronavirus outbreak continued to deepen the worst economic catastrophe since the Great ...
Testing for Coronavirus (COVID-19) in Nursing Homes. *Infection Prevention and Control Assessment Tool for Nursing Homes ... Responding to Coronavirus (COVID-19) in Nursing Homes. * ...
Use your smartphone to report any side effects after getting any vaccine dose to v-safe.
Coronavirus Protocol (Coronavirus Boneset Tea, Coronavirus Cell Protection, Coronavirus Core tincture, Coronavirus Immune ... "Wondfo Novel Coronavirus (2019-nCoV) Antibody Detection Kit". *. 06/30/2020. Center for Wellness and Integrative Medicine. " ... Corona-Cure Coronavirus Infection Prevention Nasal Spray. *. 03/26/2020. Carahealth. Herbal products, including "Carahealth ... The Prevention 12 Pak (also referred to as the Coronavirus Prevention 12 Pak), consists of the products SOUL, CORE, Cellular ...
Giving the Coronavirus emergence in Europe,we decided to share some information in easy-to-readabout the virus.The information ... Easy-to-read information about Coronavirus available in many languages. Giving the Coronavirus emergence in Europe, we decided ... Inclusion Europe > Easy-to-read > Easy-to-read information about Coronavirus available in many languages ... Click here for easy-to-read Coronavirus information in over 10 languages. ...
... tenants and local authorities in the private and social rented sectors in the context of Coronavirus (COVID-19). ... Guidance updated to link to new guidance on (COVID-19) Coronavirus restrictions: what you can and cannot do and new mediation ... This guidance provides advice to landlords and tenants on the provisions in the Coronavirus Act 2020, and further advice for ... The government has published new guidance for people with coronavirus (COVID-19) and their close contacts. ...
CORONAVIRUS. Genetic analysis suggests that the coronavirus was already circulating in Spain by mid-February. A study of the ... Four pages of newsprint have the same number of letters as the genetic code of the new coronavirus: 30,000. In that brief text ... The coronavirus, however, had already been circulating for some days, according to the genetic and epidemiological data. "No ... Just 82 days have passed since, on February 1, the first coronavirus case was detected in Spain. The patient in question was a ...
Small Business Financial Resources During Coronavirus. NFIB has collected useful resources for small business owners including ...
NHS information about the coronavirus (COVID-19) vaccine, including who can get a vaccine, how to book and how well the vaccine ... The coronavirus (COVID-19) vaccines are safe and effective. They give you the best protection against COVID-19. ...
... Elites Are Using Coronavirus As Excuse To Purge Dissidents, Author Claims. Author Jeffrey A. Tucker claims ... Fake coronavirus cures are flooding social media and experts are concerned.. By Damir Mujezinovic. Sep. 1 2021, Published 11:26 ... Anthony Fauci Says Coronavirus Fatigue Is A Real Phenomenon. Fauci says to just hang in there a bit longer. ... NFL Imposes New Coronavirus Rules As Vikings Discuss Firing Rick Dennison. It remains unclear if the Minnesota Vikings will ...
Some coronaviruses cause severe illness that can lead ... Coronaviruses are a family of viruses. Infection with these ... Coronavirus - SARS; Coronavirus - 2019-nCoV; Coronavirus - COVID-19; Coronavirus - Severe acute respiratory syndrome; ... Come in contact with a person with a severe coronavirus infection. *Travelled to a place which had an outbreak of a coronavirus ... Coronavirus disease (COVID-19). www.who.int/health-topics/coronavirus#tab=tab_1. Accessed January 21, 2023. ...
In addition to traditional SBA funding programs, the CARES Act established several new temporary programs to address the COVID-19 outbreak.
A collection of RAND research on the topic of Coronavirus ... Coronavirus. Featured. COVID-19 is a respiratory illness caused ... Discontinuation of Buprenorphine Treatment for Opioid Use Disorder During the Coronavirus Disease-2019 Pandemic: A Multilevel ... by a novel coronavirus first identified in late 2019. To help inform responses to the ongoing COVID-19 pandemic, RAND experts ...
Editors note: Find the latest COVID-19 news and guidance in Medscapes Coronavirus Resource Center. ... Cite this: More Medical Conferences Fall to Coronavirus - Medscape - Mar 09, 2020. ...
Information for Laboratories about Coronavirus (COVID-19). Information for Laboratories about Coronavirus (COVID-19) ...
The coronavirus pandemic has brought countries to a standstill. Meanwhile, vaccinations have already started in some countries ... Coronavirus vaccine trials have primarily looked at prevention of symptomatic cases of Covid-19. Previously, there has been ... The study also indicates 8.8% of the UK population had been infected with coronavirus by December - but almost twice as many ... The biggest spreaders of coronavirus in the US are adults aged 20 to 49, and efforts to control the spread -- including ...
Coronavirus Resources Aggregate List - NY-focused list of community resources, volunteer opportunities, ways to donate to local ... "Just for Kids" comic from NPR: What Kids Want To Know About Coronavirus: An Original Comic : Goats and Soda ... Trauma-Informed Guide for Families (multiple ages): Parent/Caregiver Guide to Helping Families Cope With the Coronavirus ... PBSKids "How to talk to kids": How to Talk to Your Kids About Coronavirus ...
Amid school re-openings and 6 million confirmed cases of coronavirus in the U.S., new data from the American Academy of ... According to a new report released on Wednesday, incarcerated people are twice as likely to die from coronavirus in prison than ... U.S. Coronavirus Cases Rising Rapidly Among Children. Corinne Long , August 31st, 2020 ... On March 22, Governor Greg Abbott issued an executive order banning most abortions, citing coronavirus and hospital capacity as ...
The coronavirus pandemic has brought countries to a standstill. In many places, as countries reopen, Covid-19 cases are on the ... July 15 coronavirus news. By Jessie Yeung, Steve George, Tara John, Meg Wagner, Melissa Macaya and Mike Hayes, CNN ... Yet no specific treatment for coronavirus was found over the time. There is still no cure, and doctors are applying various ... ICU deaths from coronavirus are lower than we thought, study finds. From CNNs Maggie Fox ...
Stay up to date with the latest information on the coronavirus. ... Coronavirus News. Health News. U.S. government to suspend free ... Coronavirus update: COVID-19 may be at a crossroads The CDC warns that coronavirus risks are increasing in some U.S. counties. ... Coronavirus update: Modified vaccines could be ready by the fall The FDA is making Paxlovid easier to get. COVID-19 ‌tally‌ ... Coronavirus update: Updated boosters to be available by the fall The CDC says the pandemic exposed some of its shortcomings. ...
Sign up for our special edition newsletter to get a daily update on the coronavirus pandemic. More On: italy * I flew to ... Coronavirus clinically no longer exists in Italy, doctor says By Lia Eustachewich Social Links for Lia Eustachewich * View ... Coronavirus no longer "clinically" exists in Italy, which has seen the deadly disease lose potency, according to a doctor. ... A woman undergoes a temperature scan at the entrance of the Uffizi Gallery Museum in Florence as Italy eases its coronavirus ...
JavaScript is disabled for your browser. Some features of this site may not work without it ...
www.theguardian.com › world › coronavirus-outbreakCoronavirus , The Guardian. www.theguardian.com › world › coronavirus- ... understanding-the-coronavirusHow Much Coronavirus Funding Has Gone to Your State?. www.pgpf.org › understanding-the-coronavirus ... coronavirus-dashboard.utah.gov › overviewCOVID-19 Data - Utah. coronavirus-dashboard.utah.gov › overview. ... www.fns.usda.gov › snap › state-guidance-coronavirusState Guidance on Coronavirus P-EBT , Food and ... - USDA. www.fns.usda.gov ...
Coronavirus (COVID-19). */ */ The Department of Homeland Security (DHS) efforts in preparedness and readiness have facilitated ... Coronavirus Stability Calculator. DHS Science & Technology has developed an online calculator for predicting the decay of the ... A summary of DHS actions to protect the American public from the coronavirus. ...
Learn more about the new ArcGIS Coronavirus Testing Sites and Recovery Dashboard Solutions. ... Coronavirus Recovery Solutions Available Now. Weeks after the coronavirus (COVID-19) shut down nearly every state and local ... The Coronavirus Recovery Dashboard includes a series of key recovery indicators defined by the White House Coronavirus Task ... Coronavirus recovery metrics and trends can be quickly tabulated with the Coronavirus Recovery Data Management project. Past ...
New coronavirus subvariants make gains as omicron strain BA.5 fades. What this ultimately means for this fall and winter - a ... Coronavirus surges in Europe and Asia could soon come to the United States, injecting chaos into Thanksgiving and Christmas ... As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the ... As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the ...
  • T he unprecedented uncertainty amid the coronavirus pandemic has decimated our carefully laid plans and unsettled our minds at equal pace. (chronicle.com)
  • the second, " Clarifications ," posted originally in its English translation on the humanities blog An und für sich ), Agamben brings his trademark conceptual apparatus to bear on the global response to the coronavirus pandemic. (chronicle.com)
  • To respond to the devastating health and economic effects of the coronavirus (COVID-19) pandemic, federal policymakers have enacted several bills, which include significant funding for new and existing programs to aid individuals, businesses and governments across the country. (yahoo.com)
  • The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (yahoo.com)
  • As the pandemic progressed, the damage done by the coronavirus broadened, and the toxicity of modern-day politics came to the fore. (adn.com)
  • In the face of the global coronavirus pandemic, AARP is providing information and resources to help older adults and those caring for them. (aarp.org)
  • For those of you joining us on the phone, if you'd like to ask a question about the coronavirus pandemic, press *3 on your telephone keypad to be connected with an AARP staff member who will note your name and question and place you in a queue to ask that question live. (aarp.org)
  • Sign up for our special edition newsletter to get a daily update on the coronavirus pandemic. (nypost.com)
  • Read The New Yorker's complete news coverage and analysis of the coronavirus pandemic. (newyorker.com)
  • On Oct. 1, Trump tested positive for the coronavirus, even as he continued to downplay the severity of the pandemic and suggested that the United States is winning the battle against the virus. (washingtonpost.com)
  • The Design Museum is closing its doors today, following British prime minister Boris Johnson's official advice that citizens should avoid all public gatherings and non-essential travel in light of the coronavirus pandemic. (dezeen.com)
  • I n March, the US publisher Scholastic was among those listed by Copyright Clearance Center in its learning-at-home resources as one of the companies responding to the educational crisis triggered by the coronavirus COVID-19 pandemic. (publishingperspectives.com)
  • Hawkish Sen. Tom Cotton issued a menacing statement on Thursday vowing that the United States 'will hold accountable those who inflicted' the coronavirus on the world, seeming to suggest that the Chinese government is behind the pandemic. (commondreams.org)
  • Restaurants are the riskiest public locations during the coronavirus pandemic, according to a new study . (moneytalksnews.com)
  • This article examines the meanings of the Coronavirus Pandemic from a perspective which is both socio-political and psychoanalytic. (bvsalud.org)
  • [ 3 , 4 ] More recently, the devastating pandemic of the novel coronavirus disease 2019 (COVID-19) led to a similar concern about IPA complicating the course of patients with the severe respiratory form of the disease. (medscape.com)
  • The article presents a psychoanalytic analysis of the notion of vulnerability articulated to the current context of the new coronavirus pandemic. (bvsalud.org)
  • As methodological approach, the article presents a theoretical-conceptual review of vulnerability and helplessness, inserting them in the context of the new Coronavirus pandemic. (bvsalud.org)
  • Early in the severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) pandemic , before coronavirus disease -2019 (COVID-19) vaccines were authorized, surveys began tracking public acceptance of a hypothetical COVID-19 vaccine . (bvsalud.org)
  • Canada's Ontario to Expand Use of Private Healthcare Providers Canada's most populous province, Ontario, plans to significantly expand its use of private providers to perform public health services, the premier said on Monday, in a bid to deal with backlogs and delays in a healthcare system strained by the coronavirus pandemic. (medscape.com)
  • Under the Coronavirus Aid, Relief, and Economic Security Act (CARES Act), as originally enacted March 27, 2020, the Employee Retention Credit is a refundable tax credit against certain employment taxes equal to 50% of the qualified wages an eligible employer pays to employees. (irs.gov)
  • This guidance provides advice to landlords and tenants on the provisions in the Coronavirus Act 2020, and further advice for landlords, tenants and local authorities more broadly about their rights and responsibilities during the COVID-19 outbreak. (www.gov.uk)
  • [ 5 , 6 ] On February 11, 2020, the Coronavirus Study Group of the International Committee on Taxonomy of Viruses issued a statement announcing an official designation for the novel virus: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (medscape.com)
  • Melissa Benjamin, left, a member of Colorado Care Workers Unite, returns a bottle filled with hand sanitizer to Tomeka Robinson as care workers join with the Service Employees International Union to distribute supplies to deal with the dangers of the new coronavirus Wednesday, April 29, 2020, in Denver. (denverpost.com)
  • More than 2.98 million Americans filed for unemployment last week, the Labor Department reported on Thursday, as the shutdowns caused by the coronavirus outbreak continued to deepen the worst economic catastrophe since the Great Depression. (foxbusiness.com)
  • Taiwan has been tackling its coronavirus outbreak despite being frozen out of the World Health Organization (WHO) and continual bullying from China. (foreignpolicy.com)
  • All this is done with an impressive level of public transparency and engagement, in stark contrast to China's use of draconian and coercive measures and censorship to handle the coronavirus outbreak. (foreignpolicy.com)
  • President Trump gambled very early and often on the idea that the coronavirus outbreak wouldn't turn out to be nearly as severe as some health officials warned it could get. (washingtonpost.com)
  • The National Defense Industrial Association is closely monitoring the current novel coronavirus (COVID-19) outbreak situation. (ndia.org)
  • Elba urged fans to stay home and stay safe amid the uncertainty of the global coronavirus outbreak, with his wife visibly shaken beside him. (usmagazine.com)
  • In a Feb. 17 appearance on Fox News , Cotton parroted the unfounded claim that coronavirus may have emerged from a biochemical lab in Wuhan, China, the epicenter of the outbreak. (commondreams.org)
  • Responding to the new coronavirus in the United States, an $8.3 billion bill to fight the COVID-19 outbreak was signed by President Trump. (whas11.com)
  • Smugness and arrogance and, as a result, an unchecked return to normal life has made Israel vulnerable to a second wave of the coronavirus at a time when our economic batteries are on empty and the country wasn't properly prepared to handle another outbreak. (haaretz.com)
  • Throughout the day, we will share the latest coverage from Denver Post journalists on the coronavirus outbreak on this page. (denverpost.com)
  • Also, bear in mind The Denver Post relies on support from its readers to provide this in-depth coverage of the coronavirus outbreak, so please consider buying a subscription if you haven't already. (denverpost.com)
  • Organizations providing assistance to victims of domestic violence report an increase in cases of physical and verbal abuse since the Stay at Home Order was issued in response to the coronavirus outbreak. (nbclosangeles.com)
  • Hospital outbreak of Middle East respiratory syndrome coronavirus. (who.int)
  • The U.S. Food and Drug Administration is issuing warning letters to firms for selling fraudulent products with claims to prevent, treat, mitigate, diagnose or cure coronavirus disease 2019 (COVID-19) . (fda.gov)
  • it doesn't mean that you have the Coronavirus disease for sure. (inclusion-europe.eu)
  • to not get the Coronavirus disease. (inclusion-europe.eu)
  • reports on the coronavirus disease. (democracynow.org)
  • The Oxford-AstraZeneca Covid-19 vaccine may reduce coronavirus transmission, rather than simply reducing the severity of disease, according to researchers. (cnn.com)
  • The coronavirus is a virus that causes a contagious disease known as Covid-19. (mediaite.com)
  • Coronavirus no longer "clinically" exists in Italy, which has seen the deadly disease lose potency , according to a doctor. (nypost.com)
  • The National Adverting Division has joined in the battle against coronavirus disease claims by advising a company marketing a superfoods blend to take down a video that NAD says crosses the line. (nutraingredients-usa.com)
  • Illness caused by SARS-CoV-2 was termed COVID-19 by the WHO, the acronym derived from "coronavirus disease 2019. (medscape.com)
  • At that time, the rapid rise in coronavirus cases - both within the country and among travelers - was so concerning, a joint WHO and European Center for Disease Prevention and Control mission went to Italy to figure out what was going on. (vox.com)
  • More than 100,000 people worldwide have been infected by the coronavirus, and the COVID-19 disease caused by the virus has killed more than 3,400. (whas11.com)
  • Invasive pulmonary aspergillosis (IPA) can affect patients with severe coronavirus disease 2019 (COVID-19), but many questions remain open about its very variable incidence across the world, the actual link between the viral infection and the fungal superinfection, the significance of Aspergillus recovery in a respiratory sample, and the management of such cases. (medscape.com)
  • What is the Actual Prevalence of Coronavirus Disease 2019-associated Pulmonary Aspergillosis? (medscape.com)
  • Globally, there is still much to learn about the evolving coronavirus disease 2019 (COVID-19) virus , its transmission , prevention, and treatment . (bvsalud.org)
  • The HIV community and response have much to offer to the coronavirus disease 2019 (COVID-19) preparedness and resiliency. (bvs.br)
  • Dec 06, 2022 · At least 1 in 313 residents have died from the coronavirus , a total of 2,434 deaths. (yahoo.com)
  • A woman undergoes a temperature scan at the entrance of the Uffizi Gallery Museum in Florence as Italy eases its coronavirus lockdown. (nypost.com)
  • The Trump administration is reviewing new proposed guidelines for how states can gradually reopen businesses, schools and churches, while more state governors signaled their plans to move forward with easing of coronavirus lockdown restrictions. (voanews.com)
  • First Minister Mark Drakeford has said the Welsh Government is prepared to increase fines for those breaking coronavirus lockdown laws. (itv.com)
  • Amy Harmon and Rich Rojas at The New York Times are writing in their coverage updated this morning (June 8), "None of the plans for how the nation might safely emerge from the coronavirus lockdown involved thousands of Americans standing shoulder to shoulder in the streets of major cities or coughing uncontrollably when the authorities used tear gas to disperse them. (publishingperspectives.com)
  • Global lockdowns in response to the coronavirus have resulted in economic turmoil and what is expected to be the worst downturn since the Great Depression in the 1930s. (forbes.com)
  • Coronavirus is also called COVID-19. (inclusion-europe.eu)
  • Non-statutory guidance for landlords, tenants and local authorities in the private and social rented sectors in the context of Coronavirus (COVID-19). (www.gov.uk)
  • Check up-to-date coronavirus (COVID-19) guidance and information . (www.gov.uk)
  • The government has published new guidance for people with coronavirus (COVID-19) and their close contacts . (www.gov.uk)
  • Updated following the extension of Step 3 of the coronavirus (COVID-19) roadmap on Monday 21 June. (www.gov.uk)
  • Guidance updated to link to new guidance on (COVID-19) Coronavirus restrictions: what you can and cannot do and new mediation guidance. (www.gov.uk)
  • The coronavirus (COVID-19) vaccines are safe and effective. (www.nhs.uk)
  • COVID-19 is a respiratory illness caused by a novel coronavirus first identified in late 2019. (rand.org)
  • Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center . (medscape.com)
  • After criticism last year for an early rollout, Russia's Sputnik V coronavirus vaccine is 91.6% effective against symptomatic Covid-19, according to interim analysis published Tuesday. (cnn.com)
  • Amid school re-openings and 6 million confirmed cases of coronavirus in the U.S., new data from the American Academy of Pediatrics shows that instances of COVID-19 related hospitalizations and deaths among children and teens are increasing at a more rapid pace than the general public. (feminist.org)
  • The Trump Administration is expelling immigrant children citing COVID-19 concerns, despite the children testing negative for the coronavirus before they are put on planes to their home countries. (feminist.org)
  • DHS Science & Technology has developed an online calculator for predicting the decay of the virus that causes Coronavirus (COVID-19). (dhs.gov)
  • Weeks after the coronavirus (COVID-19) shut down nearly every state and local government in the United States, many communities have started turning their attention to reopening and recovery efforts. (esri.com)
  • Millions of people living in the United States are being told to stay at home to help slow the spread of Coronavirus (COVID-19). (cdc.gov)
  • Airlines are starting to offer travel waivers due to the growing concern over the new coronavirus, COVID-19. (firstcoastnews.com)
  • Coronavirus (COVID-19) Situation reports are now included in The WHO Africa outbreaks and emergencies bulletin. (who.int)
  • This map, hereafter referred to as the "EIOS COVID-19 Map", showing some of the most recent news about the novel coronavirus (SARS-CoV-2), cycles through each news item before being refreshed and re-running the cycle. (who.int)
  • The Coronavirus Recovery Dashboard includes a series of key recovery indicators defined by the White House Coronavirus Task Force and specific metrics identified by the United States National Governors Association (NGA). (esri.com)
  • The overall number of global coronavirus cases has surpassed 300 million, while the deaths have surged to more than 5.47 million and vaccinations to over 9.33 billion,, according to the Johns Hopkins. (dailynews.lk)
  • Muller MA , Paweska JT , Leman PA , Drosten C , Grywna K , Kemp A , Coronavirus antibodies in African bat species. (cdc.gov)
  • The move is intended to both slow the spread of coronavirus and speed up reopening the economy. (uci.edu)
  • The additional funding "will be instrumental in helping us prepare to slow the spread of coronavirus," said Lt. Gov. Spencer Cox, who is leading a task force dealing with the virus. (whas11.com)
  • The U.S. death toll from the coronavirus reached 14 on Friday, with one death in California and the rest in Washington state. (whas11.com)
  • Teen Mom 2' star Kailyn Lowry has revealed she won't vaccinate herself, or her children, against the coronavirus when a vaccine is created. (hollywoodlife.com)
  • A Harris County doctor was fired and faces a criminal charge after authorities say he stole coronavirus vaccine to benefit his family and friends. (dallasnews.com)
  • MERS is caused by the MERS-CoV coronavirus. (medlineplus.gov)
  • coronaviruses similar to MERS- detection of virus in different secretions, detection and CoV have been identified in bats ( 6 ), but epidemiologic survival of virus in the environment, and detection evidence of their role in transmission is lacking. (cdc.gov)
  • Saudi Arabian researchers have detected genetic fragments of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the air of a barn holding a camel infected with the virus. (eurekalert.org)
  • Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was confirmed today in a traveler to the United States. (cdc.gov)
  • Interim U.S. Guidance for Monitoring and Movement of Persons with Potential Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Exposure [cited 2018 8 April]. (who.int)
  • Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity. (who.int)
  • It is caused by the SARS-CoV coronavirus. (medlineplus.gov)
  • It is caused by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). (medlineplus.gov)
  • At this time, there is no specific treatment for coronavirus infection except for SARS-CoV-2. (medlineplus.gov)
  • For a coronavirus infection not due to SARS-CoV-2, medicines are given only to ease your symptoms. (medlineplus.gov)
  • The causative agent was acute respiratory infections, 70 HCoV-229E-positive se- identifi ed as a coronavirus (SARS-CoV) ( 2 - 4 ), and related rum specimens and 4 HCoV-NL63-positive serum speci- viruses found in palm civets ( Paguma larvata ), raccoon mens (provided by L. van der Hoek). (cdc.gov)
  • Woo PC , Lau SK , Wong BH , Chan KH , Hui WT , Kwan GS , False-positive results in a recombinant severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid enzyme-linked immunosorbent assay due to HCoV-OC43 and HCoV-229E rectified by Western blotting with recombinant SARS-CoV spike polypeptide. (cdc.gov)
  • The extended school closures caused by the coronavirus crisis have upended the nation's after-school programs, leaving most with no children to serve and no schools to operate out of. (edweek.org)
  • The coronavirus crisis is placing huge demands on American workers. (nutraingredients-usa.com)
  • Prime Minister Benjamin Netanyahu's handling of the coronavirus crisis continues to be a resounding failure. (haaretz.com)
  • The coronavirus is a civilian crisis, and the Shin Bet should be left out of it. (haaretz.com)
  • Perhaps it's now time for Netanyahu to call them and ask what Israel can learn from them about managing the coronavirus crisis. (haaretz.com)
  • Many people infected by the coronavirus develop symptoms like a fever and dry cough during the incubation period . (harvard.edu)
  • The Coronavirus Recovery Dashboard solution can be used to tabulate symptoms, cases, and hospital capacity metrics, monitor key recovery trends and performance targets, and communicate progress made to interested stakeholders. (esri.com)
  • What are coronavirus symptoms? (firstcoastnews.com)
  • Anyone with symptoms matching coronavirus, including a fever, cough, or shortness of breath, is asked to stay away from public spaces. (whas11.com)
  • We have two quarantine areas, so we are not denying help to anyone, even if they have coronavirus symptoms," she said. (nbclosangeles.com)
  • NBC News' Stephanie Ruhle reports from the New York Stock Exchange amid coronavirus fears. (msnbc.com)
  • Amid the heartbreaking loss of life and economic hardship wrought by the coronavirus, we recognize the need for stories of kindness, hope, courage and humor. (uci.edu)
  • HOUSTON - Several employees and customers tested positive for the new coronavirus after going to McIntyre's , a bar in the Heights. (khou.com)
  • Health officials said two people who tested positive for the new coronavirus have died in Florida. (whas11.com)
  • Its over 3,500 passengers are confined to their cabins as 21 people aboard the huge cruise ship have tested positive for the new coronavirus. (whas11.com)
  • President Donald Trump and first lady Melania Trump tested positive for the coronavirus, adding Trump to a short list of world leaders who have contracted the virus. (cnbc.com)
  • President Trump's campaign manager Bill Stepien has tested positive for coronavirus, Trump Campaign Director of Communications Tim Murtaugh confirmed Friday. (cnbc.com)
  • Kellyanne Conway, former counselor to President Donald Trump, tweeted that she has tested positive for coronavirus. (cnbc.com)
  • Over the past four months, President Trump has regularly sought to downplay the coronavirus threat with a mix of facts and false statements. (washingtonpost.com)
  • Fue uno de los principales miembros del grupo de trabajo sobre coronavirus de la Casa Blanca durante el gobierno de Donald Trump. (mcall.com)
  • Some animal coronaviruses evolve (mutate) and are passed from animals to humans. (medlineplus.gov)
  • Antigenic cross-reactivity between the nucleocapsid protein of severe acute respiratory syndrome (SARS) coronavirus and polyclonal antisera of antigenic group I animal coronaviruses: implication for SARS diagnosis. (cdc.gov)
  • Summary of Middle East respiratory syndrome coronavirus transmission pathways. (cdc.gov)
  • Nearly 90% of coronavirus deaths happened in countries where most of the population was overweight , according to a new study . (uci.edu)
  • We encourage Marin County residents to report home based testing results to https://coronavirus.marinhhs.org/SelfTestReporting . (marinhhs.org)
  • Some coronaviruses cause severe illness that can lead to pneumonia, and even death. (medlineplus.gov)
  • Severe coronavirus infections may require hospitalization and breathing support. (medlineplus.gov)
  • Rarely, certain severe coronavirus infections may lead to death, especially in older people, children, or people with chronic conditions. (medlineplus.gov)
  • Asian bats have been identifi ed as potential reservoir tive-bred Rousettus aegyptiacus at the National Institute hosts of coronaviruses associated with severe acute respira- for Communicable Diseases, Sandringham, SA. (cdc.gov)
  • Lau SK , Woo PC , Li KS , Huang Y , Tsoi HW , Wong BH , Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. (cdc.gov)
  • Haynes LM , Miao C , Harcourt JL , Montgomery JM , Le MQ , Dryga SA , Recombinant protein-based assays for detection of antibodies to severe acute respiratory syndrome coronavirus spike and nucleocapsid proteins. (cdc.gov)
  • Worrying about all the news on the new coronavirus and the illness it causes? (harvard.edu)
  • Get all the latest news on coronavirus and more delivered daily to your inbox. (foxbusiness.com)
  • Get expert buying tips about Coronavirus News delivered to your inbox. (consumeraffairs.com)
  • Conway's daughter broke the news that her mother had tested positive for coronavirus on TikTok, complaining about the fact that she had attended the event. (cnbc.com)
  • This section curates noteworthy coronavirus news, trends and opinions. (uci.edu)
  • The cold chain storage for coronavirus vaccines "is a really tricky process," Walgreens chief medical officer Dr. Kevin Ban said on Tuesday. (cnn.com)
  • The impromptu remarks on "60 Minutes" come as officials struggle to secure new funding for coronavirus vaccines, tests and treatments. (adn.com)
  • Even greater than the official coronavirus toll may be the collateral damage wrought by an overstretched health system: the pregnant women and babies, cancer and HIV patients, and children in need of vaccines who are now less likely to get the health care they need. (vox.com)
  • Coronavirus variants are dodging antibody treatments. (washingtonpost.com)
  • Antibody reactivity to coronavirus (CoV) nucleocapsid (N) protein fragments by ELISA. (cdc.gov)
  • Mild coronavirus infections, such as the common cold, will go away in a few days with rest and self care at home . (medlineplus.gov)
  • Coronavirus infections may lead to bronchitis or pneumonia. (medlineplus.gov)
  • The researchers concluded that a small number of public places are responsible for the lion's share of coronavirus infections. (moneytalksnews.com)
  • As the new coronavirus sweeps across much of the world and cases exceed 160,000, there is one country that seems to have things under control, despite being only 110 miles from China and having experienced its first case on Jan. 21. (foreignpolicy.com)
  • Florida added 1,707 coronavirus cases Monday to bring the statewide total to 756,727 cases. (orlandosentinel.com)
  • The latest breakdown of Florida's coronavirus cases can be found here . (orlandosentinel.com)
  • The Navajo Nation has seen a significant spike in coronavirus cases. (npr.org)
  • The number of coronavirus cases on the Navajo Nation is multiplying rapidly. (npr.org)
  • UAE officials earlier confirmed there were no cases of coronavirus in the country, adding it was "in constant touch with the World Health Organization (WHO) to find out latest updates, recommendations and procedures taken in this matter. (arabnews.com)
  • The major reason for the extreme response: Cases in Italy escalated fast and the coronavirus overwhelmed the country's health system, particularly in the north. (vox.com)
  • Officials in Minnesota, Kentucky and South Carolina have confirmed possibly the first cases of the new coronavirus in each state. (whas11.com)
  • coronavirus -dashboard. (yahoo.com)
  • You can configure the Coronavirus Recovery Dashboard solution to monitor other metrics established for your organization. (esri.com)
  • According to a new report released on Wednesday, incarcerated people are twice as likely to die from coronavirus in prison than those on the outside. (feminist.org)
  • We can't have thousands of people coming in who may have this problem, the coronavirus. (washingtonpost.com)
  • Since it emerged in December 2019, the coronavirus has officially killed over 6m people, though our own estimate suggests the actual toll exceeds 20m. (economist.com)
  • They joined Georgia, Oklahoma, Alaska and South Carolina in the push to put people back to work and allow residents to get back to some semblance of their pre-coronavirus lives. (voanews.com)
  • The virus has infected over 40 million people and has killed over 1.1 million worldwide, according to the Johns Hopkins University & Medicine Coronavirus Resource Center . (orlandosentinel.com)
  • There was a large turnout Monday at the coronavirus pop-up testing site in Forest Park.Testing began at 1 p.m. at this pop-up site, but some people arrived several hours early.Chelle Smith wanted to be one of the first through the process. (wlwt.com)
  • Italy has imposed unprecedented national restrictions on its 60 million people to control the spread of the coronavirus. (vox.com)
  • How many people have died from coronavirus? (whas11.com)
  • Last Wednesday, the Knesset passed temporary legislation enabling the Health Ministry to seek the Shin Bet security service's help in identifying people who had contact with coronavirus patients. (haaretz.com)
  • The day after the law passed, the ministry began sending messages to tens of thousands of people telling them to quarantine because they were near a confirmed coronavirus patient. (haaretz.com)
  • When anxiety rises because we're facing a distressing threat like the new coronavirus, we need to focus on what tends to work for us to ease anxiety - that, plus doing a little bit more of some actions and a little bit less of others. (harvard.edu)
  • The threat of coronavirus will impact the operation of court systems. (taylorwessing.com)
  • There are many other coronaviruses circulating in animals, but they haven't spread to humans. (medlineplus.gov)
  • Once a person has been infected by a coronavirus, the infection can spread to a healthy person (person-to-person transmission). (medlineplus.gov)
  • Human coronaviruses that cause the common cold spread from person-to-person. (medlineplus.gov)
  • Testing can also be used to characterize the prevalence, spread and contagiousness of coronavirus as public health officials begin recovery and reopening efforts. (esri.com)
  • For the latest information about how to stop the spread or to learn more about the federal response, visit coronavirus.gov , cdc.gov/coronavirus , and USA.gov/Coronavirus . (usda.gov)
  • Soldiers take part in a drill organized by the New Taipei City government to prevent the spread of the new coronavirus. (foreignpolicy.com)
  • Church services resumed in Montana as the state began to ease restrictions meant to stop the spread of the coronavirus. (voanews.com)
  • Louisiana Governor John Bel Edwards said Monday he would extend his state's stay-at-home orders through May 15 because some areas have not yet shown enough progress in slowing the spread of the coronavirus. (voanews.com)
  • So when he heard on the radio how often and for how long he was supposed to wash his hands to avoid the spread of the coronavirus, he was overwhelmed. (npr.org)
  • Because police stations have closed their reception areas in response to the spread of the coronavirus, victims should contact their nearest police department over the phone in case they need a temporary restraining order or an emergency protective order. (nbclosangeles.com)
  • By Wednesday, Prime Minister Giuseppe Conte added new coronavirus restrictions, ordering most businesses - except grocery stores and pharmacies - closed. (vox.com)
  • In April, New Orleans health officials realized their drive-through testing strategy for the coronavirus wasn't working. (npr.org)
  • The New York Times reported federal officials as saying that the Food and Drug Administration (FDA) is expected to grant expanded emergency use authorization to allow children as young as 12 to receive the coronavirus. (arabamericannews.com)
  • The first known case of the new coronavirus has arrived in Utah, state and local health officials said Friday night. (whas11.com)
  • On Thursday, the U.S. Department of Labor and Colorado officials announced that more than 30 million Americans and about 380,000 Coloradans had applied for unemployment aid since the coronavirus hit. (denverpost.com)
  • Polk County, due to nursing-home outbreaks, has the most coronavirus fatalities in the region with 589, followed by 534 in Orange, 347 in Brevard, 307 in Volusia, 235 in Seminole, 218 in Lake, 182 in Osceola, and 80 in Sumter. (orlandosentinel.com)
  • Italy - the first country in the world to surpass China's coronavirus death toll - was the first European country to lock down in early March. (nypost.com)
  • Italy and China used lockdowns to slow the coronavirus. (vox.com)
  • IMSEAR at SEARO: Coronavirus in respiratory infection. (who.int)
  • Coronavirus in respiratory infection. (who.int)
  • Many coronaviruses originate in bats, which can infect other animals. (medlineplus.gov)
  • Li W , Shi Z , Yu M , Ren W , Smith C , Epstein JH , Bats are natural reservoirs of SARS-like coronaviruses. (cdc.gov)
  • Detection of group 1 coronaviruses in bats in North America. (cdc.gov)
  • Coronavirus recovery metrics and trends can be quickly tabulated with the Coronavirus Recovery Data Management project. (esri.com)
  • Fourteen days is the quarantine period health experts recommend because that's the standard quarantine time for other types of coronavirus. (firstcoastnews.com)
  • The Wuhan coronavirus is a grave challenge to our great nation,' said Cotton, who announced he is temporarily closing his Washington, D.C. office as a precautionary measure. (commondreams.org)