Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Coronaviridae: Spherical RNA viruses, in the order NIDOVIRALES, infecting a wide range of animals including humans. Transmission is by fecal-oral and respiratory routes. Mechanical transmission is also common. There are two genera: CORONAVIRUS and TOROVIRUS.Nidovirales: An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.SARS Virus: A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.Oxytocics: Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)Receptors, Oxytocin: Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Sample Size: The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)Probability Theory: The branch of mathematics dealing with the purely logical properties of probability. Its theorems underlie most statistical methods. (Last, A Dictionary of Epidemiology, 2d ed)Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Immunization, Secondary: Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Vaccines, DNA: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.Severe Acute Respiratory Syndrome: A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.Ventilation-Perfusion Ratio: The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Respiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Middle East: The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)Influenza B virus: Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Saudi ArabiaIsotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Porcine Reproductive and Respiratory Syndrome: A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Hemagglutinin Glycoproteins, Influenza Virus: Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.Hemagglutinins, Viral: Specific hemagglutinin subtypes encoded by VIRUSES.Salmonella Vaccines: Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Hemagglutinins: Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.Torovirus: A genus of the family CORONAVIRIDAE characterized by enveloped, peplomer-bearing particles containing an elongated tubular nucleocapsid with helical symmetry. Toroviruses have been found in association with enteric infections in horses (Berne virus), cattle (Breda virus), swine, and humans. Transmission probably takes place via the fecal-oral route.Dictionaries, MedicalTorovirus Infections: Infections with viruses of the genus TOROVIRUS, family CORONAVIRIDAE.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Mamastrovirus: A genus of small, circular RNA viruses in the family ASTROVIRIDAE. They cause GASTROENTERITIS and are found in the stools of several vertebrates including humans. Transmission is by the fecal-oral route and there are at least eight human serotypes. The type species is Human astrovirus.Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.Dictionaries, ChemicalTogaviridae: A family of RNA viruses, mainly arboviruses, consisting of two genera: ALPHAVIRUS (group A arboviruses), and RUBIVIRUS. Virions are spherical, 60-70 nm in diameter, with a lipoprotein envelope tightly applied to the icosahedral nucleocapsid.Medical Futility: The absence of a useful purpose or useful result in a diagnostic procedure or therapeutic intervention. The situation of a patient whose condition will not be improved by treatment or instances in which treatment preserves permanent unconsciousness or cannot end dependence on intensive medical care. (From Ann Intern Med 1990 Jun 15;112(12):949)Alternaria: A mitosporic Loculoascomycetes fungal genus including several plant pathogens and at least one species which produces a highly phytotoxic antibiotic. Its teleomorph is Lewia.Early Termination of Clinical Trials: Earlier than planned termination of clinical trials.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

In situ hybridization for the detection and localization of porcine epidemic diarrhea virus in the intestinal tissues from naturally infected piglets. (1/118)

Detection and localization of porcine epidemic diarrhea virus (PEDV) was studied by in situ hybridization with a nonradioactive digoxigenin-labeled probe in formalin-fixed, paraffin-embedded tissues from 10 naturally infected piglets. A 377-base pair cDNA probe for viral RNA encoding the membrane proteins of PEDV cell-culture-adapted strain V215/78 was generated by the reverse transcription polymerase chain reaction. In the retrospective study of pigs from herds with diarrhea, the 10 piglets naturally infected with PEDV had positive signals for PEDV by in situ hybridization. When intestinal tissues were hybridized with the PEDV probe, a strong signal was seen in the villus enterocytes of jejunum and ileum but not in the cecum and colon. Positive cells typically had dark brown reaction products in the cytoplasm. Scattered epithelial cells along the ileal Peyer's patches dome areas contained viral RNA. In one piglet, hybridization signal was also found in the duodenum. PEDV was not demonstrated in tissues outside of the intestinal tract. These findings indicate that jejunal and ileal villus enterocytes are the main target of PEDV replication during epizootic outbreaks of the disease.  (+info)

Viremia-associated ana-aki-byo, a new viral disease in color carp Cyprinus carpio in Japan. (2/118)

A new virus disease that displays dermal ulceration and high mortality has been occurring since 1996 in color carp Cyprinus carpio reared in warm water in Japan. In histological examinations, initial erosive lesions displayed necrosis, hemorrhage and fibrin deposition in the dermal loose connective tissue and were accompanied by the partial destruction of the epidermis. Developed ulcerative lesions involved the lateral musculature with bacterial invasions. In visceral organs, necrotic cells were observed in the hematopoietic tissue, the spleen and the intestinal tissues as well as in cardiac muscle fibers which showed no signs of bacterial invasion. Electron microscopy revealed corona-like virus particles in these necrotic cells. The necrotic cells of the hematopoietic tissue and the spleen were accompanied by the formation of tubular structures and crystalline inclusions. The putative virus was isolated and cultured in epithelioma papillosum cyprini (EPC) cells. Carp experimentally inoculated with the cultured virus showed virus transmission, and the same pathological signs of the disease and mortalities as in natural infections.  (+info)

The effects of coronavirus on human nasal ciliated respiratory epithelium. (3/118)

Human coronavirus (HCoV) accounts for 15-30% of common colds, but only one case report has described the effect of a coronavirus infection, that was asymptomatic, on human respiratory epithelium. The authors examined the effects of infection with HCoV on ciliary structure and function in healthy volunteers infected by intranasal inoculation with HCoV 229E. A further four volunteers were sham infected with ultraviolet-inactivated virus. Immediately before inoculation (day 0) and 3 days later (day 3), ciliated epithelium was obtained by brushing the inferior nasal turbinate. Ciliary beat frequency was determined and beat pattern analysed for evidence of dyskinesia (0=normal, 3=severely dyskinetic) using digital high-speed video photography. Ciliary ultrastructure was examined by transmission electron microscopy. Symptom diaries were kept for the duration of the study. All subjects inoculated with HCoV, including the three who did not develop symptoms of an upper respiratory tract infection, had disruption of their respiratory epithelium on day 3. Although there was no difference in the mean ciliary beat frequency between day 0 (11.3 Hz (95% confidence interval (CI): 8.6-14.0) and day 3 (9.4 Hz (95% CI 7.2-11.6)), there was a significant increase (p<0.05) in the ciliary dyskinesia score between day 0 (0.2 (95% CI 0-0.5)) and day 3 (1.1 (95% CI 0.5-1.7). In sham-infected subjects, no differences in epithelial integrity, or ciliary structure and function were found between day 0 and day 3. Inoculation of healthy volunteers with human coronavirus caused disruption of the ciliated epithelium and ciliary dyskinesia. This is likely to impair mucociliary clearance. Damage to the respiratory epithelium, due to human coronavirus infection, may occur without overt clinical symptoms.  (+info)

Monoclonal antibody-based immunohistochemical detection of porcine epidemic diarrhea virus antigen in formalin-fixed, paraffin-embedded intestinal tissues. (4/118)

An immunohistochemistry technique was developed for the diagnosis of porcine epidemic diarrhea virus (PEDV). The technique was tested on formalin-fixed, paraffin-embedded intestinal tissues from piglets naturally infected with PEDV. Five different monoclonal antibodies (MAbs) were tested in this study. PEDV antigen was consistently detected in the PLP (4% paraformaldehyde, 100 mM L-lysine dihydrochloride, 10 mM sodium m-periodate in phosphate-buffered saline)-fixed PEDV-infected Vero cells or formalin-fixed, paraffin-embedded intestinal tissues from piglets naturally infected with PEDV. The C9-2-2 MAb gave the strongest reactivity and least background staining, detecting 10 of 10 infected pigs. The positive reaction was cytoplasmic. Positive enterocytes were distributed over the tip and along the sides of atrophied or fused villi in the jejunum and ileum. Positive-staining cells were not detected in the crypts. No staining was observed in cecum and colon. No positive cells were observed when the C9-2-2 MAb was reacted with the tissue sections from noninfected piglets or from transmissible gastroenteritus virus (TGEV)- and rotavirus-infected piglets. The selected anti-PEDV MAbs tested on formalin-fixed, paraffin-embedded tissue sections are useful for diagnosis when virus isolation is not available. This method would be of particular value in countries where both PEDV and TGEV are epizootic and would aid in differentiating between PEDV and TGEV infection.  (+info)

Redistribution and reduction of interphotoreceptor retinoid-binding protein during ocular coronavirus infection. (5/118)

Inoculation of the neurotropic coronavirus mouse hepatitis virus strain JHM intravitreally or into the anterior chamber causes acute infection of the retinal pigment epithelium (RPE) and neural retina. Weeks later, many retinas have foci of moderate to severe atrophy. The effect of coronavirus infection (after intravitreal inoculation) was examined on interphotoreceptor retinoid-binding protein (IRBP), the glycolipoprotein in the interphotoreceptor matrix (IPM) thought to transport retinoids between the photoreceptors and the RPE. Changes in IRBP distribution accompanied virus-associated retinal pathology, including photoreceptor loss and RPE abnormalities. Immunohistochemistry on days 3 and 6 showed that IRBP had diffused into the neural retina away from the IPM. The IRBP became localized abnormally in the same areas as virus-induced lesions, shown by staining adjacent sections with a monoclonal antibody specific for the viral nucleocapsid protein. Moreover, the level of IRBP in isolated retinas, measured in an immunoslot-blot assay, decreased significantly by day 3 and remained low through day 23. This decrease was confirmed in eyecups isolated on day 6. It may be caused in part by loss of photoreceptors and diffusion of IRBP through the retina into the vitreous. These studies show that a virus may induce an acute, limited infection in the retina that can be cleared by the host. However, the infection initiated a series of events resulting in long-term reduction and redistribution of a critical photoreceptor protein.  (+info)

Epithelia-damaging virus infections affect vitamin A status in chickens. (6/118)

The effect of infection with infectious bronchitis virus (IBV) and reovirus (RV) on vitamin A status was investigated in chickens with a normal or marginal intake of vitamin A. At the age of 4 wk, chickens were infected with either IBV or RV, primarily affecting the respiratory or intestinal tract, respectively. Both viruses lowered plasma retinol levels significantly. The effect was more pronounced in chickens fed a diet marginally deficient in vitamin A than in those fed a diet adequate in vitamin A. Concentrations of retinol-binding protein, transthyretin and albumin in RV-infected chickens were also significantly lower than in noninfected chickens fed the same diets; in chickens infected with IBV, there was no effect. These results suggest that the reduced vitamin A status of IBV-infected chickens could be attributed to increased rate of utilization by tissues. In RV infection, this mechanism could be involved but impaired absorption of nutrients (including vitamin A) and direct loss of nutrients via the intestinal tract could also be important.  (+info)

Seroconversion of pigs in contact with dogs exposed to canine coronavirus. (7/118)

In order to determine if canine coronavirus (CCV) could be transmitted to pigs, two dogs were inoculated orally with virulent CCV. After 24 h, the dogs were moved to an isolation room that contained three three-day-old pigs. A wire mesh fence, allowing close contact between the animals, separated the dogs from the pigs. The dogs and pigs were observed for 14 days for clinical signs of disease. Samples of blood were obtained from dogs and pigs immediately before the dogs were inoculated with virus and 14 and 28 days later. The dogs developed mild clinical signs of an infection, but the pigs remained normal throughout the observation period. The dogs shed CCV for eight days after exposure. All three pigs developed neutralizing antibodies against CCV and transmissible gastroenteritis virus by 14 days after they were exposed to the dogs.  (+info)

Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells. (8/118)

The importance of N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) as a receptor determinant for bovine coronavirus (BCV) on cultured cells was analysed. Pretreatment of MDCK I (Madin Darby canine kidney) cells with neuraminidase or acetylesterase rendered the cells resistant to infection by BCV. The receptors on a human (CaCo-2) and a porcine (LLC-PK1) epithelial cell line were also found to be sensitive to neuraminidase treatment. The susceptibility to infection by BCV was restored after resialylation of asialo-MDCK I cells with Neu5,9Ac2. Transfer of sialic acid lacking a 9-O-acetyl group was ineffective in this respect. These results demonstrate that 9-O-acetylated sialic acid is used as a receptor determinant by BCV to infect cultured cells. The possibility is discussed that the initiation of a BCV infection involves the recognition of different types of receptors, a first receptor for primary attachment and a second receptor to mediate the fusion between the viral envelope and the cellular membrane.  (+info)

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Dr. David Ho, scientific director and CEO of the Aaron Diamond AIDS Research Center, talks with Rachel Maddow about new research into using antibodies from COVID-19 survivors in developing a treatment or vaccine against new coronavirus infections.
Roche has received Emergency Use Authorization in the USA for an antibody test in connection with the novel coronavirus. The tests are already being distributed around the world. In May, production capacities are to already be scaled up to the high double-digit million area.
Vanguard Genetics, located on the campus of NMSU, is now among a relatively small number of laboratories in the U.S. testing for COVID-19 antibodies.
Really, just looking at the plain factual numbers up there the CoronaVirus or Covid-19 does not deserve the fuzz and frenzy like behaviors Media (and you b) are making it out to be. Yes the management of the crisis by the countries state government of the world has been poor, inefficient and shameful while the death toll is saddening and emotionally wrenching in every way. Yet, the Coronavirus is far from deserving massive human quarantine ,closing of borders, stopping airplanes traffic, cancelling main events and social life and asking specific papers and proof of good health to go around about (France , Italy...). Locking up about 99.99 percent of the world population for a few coronavirus cases is insane and inefficient*; absolutely insane and mad.I hope you understand it b. A huge part of the economy made of casual and average folks (and not the vultures and/or mega rich using every made up crisis or not to buy bonds for peanuts and increase their already insane wealth later once the crisis ...
Really, just looking at the plain factual numbers up there the CoronaVirus or Covid-19 does not deserve the fuzz and frenzy like behaviors Media (and you b) are making it out to be. Yes the management of the crisis by the countries state government of the world has been poor, inefficient and shameful while the death toll is saddening and emotionally wrenching in every way. Yet, the Coronavirus is far from deserving massive human quarantine ,closing of borders, stopping airplanes traffic, cancelling main events and social life and asking specific papers and proof of good health to go around about (France , Italy...). Locking up about 99.99 percent of the world population for a few coronavirus cases is insane and inefficient*; absolutely insane and mad.I hope you understand it b. A huge part of the economy made of casual and average folks (and not the vultures and/or mega rich using every made up crisis or not to buy bonds for peanuts and increase their already insane wealth later once the crisis ...
RARITAN, N.J., April 3, 2020 /PRNewswire/ -- Aligned with its mission to improve and save lives with diagnostics, Ortho Clinical Diagnostics today announced it is launching to market its SARS-CoV-2 (COVID-19/coronavirus) antibody test-the VITROS® Immunodiagnostic Products Anti-SARS-CoV-2 Total Reagent Pack. Testing...
Investors are bracing for what could be the sharpest drop in quarterly earnings for S&P 500 firms since the financial crisis, according to IBES Refinitiv data. Results from big banks will be in focus this week.. The April-June reports will reveal the extent of the damage wreaked by coronavirus-induced lockdowns on corporate profits. With a recent jump in cases in the United States that has made Florida, Arizona, Texas and California the new epicenters, analysts are predicting that S&P 500 earnings will return to growth only by 2021.. The S&P 500, which is about 5% below its record high hit in February, briefly turned positive for the year on an intraday basis for the second time since the coronavirus-induced crash.. At 12:58 p.m. ET, the Dow Jones Industrial Average rose 468.05 points, or 1.79%, to hit its highest level in nearly four weeks at 26,543.35.. The S&P 500 was up 40.05 points, or 1.26%, at 3,225.09 and the Nasdaq Composite gained 142.61 points, or 1.34%, at 10,760.06.. Healthcare ...
Turkey confirmed its first case of the coronavirus on Wednesday, becoming the last major economy to report an outbreak after taking what the World Health Organization (WHO) described as
A former Maharashtra chief minister tested positive for coronavirus on Sunday. He is currently admitted at a hospital in Marathwada. The leader, who is a minister in the current...
Over the past few weeks, the COVID-19 virus has swept across the nation, causing more than just small disruptions in everyday life in the United States. Understanding how Americans have had their individual lives distorted or destroyed by stay-at-home orders, layoffs, or the disease itself, is a step that must be taken to understand how the country can move forward. FreedomWorks, in response, has begun polling our audience on the effects of Coronavirus on their families, employment, and optimism. ...
We are receiving a number of queries as to the impact of Coronavirus on our ability to despatch orders. We can assure you that we are functioning normally and all orders are being processed swiftly and despatched into the DHL delivery network. DHLs global network is currently operating as normal, including delivering into affected areas. We are in regular contact with DHL and will inform you, by updating this message, if the situation changes.. Keep well!. The Alfaholics Team ...
The effects of coronavirus on the economy already appear bleak. Unemployment and government borrowing are soaring and a recession seems inevitable.
Supply-chain disruptions in China and non-China regions due to the coronavirus-induced global lockdown expected to have hurt Ambarellas (AMBA) fiscal first-quarter performance.
Consistent with a previous report on SDAV structural proteins (1), the coding sequences for the S, M, and N proteins were identified. Downstream of the S-protein gene, two overlapping potentially nonstructural-protein genes were located, and these were predicted to encode 15- and 12.6-kDa nonstructural proteins. A small internal ORF (ORF7b) was also found in the +2 frame within the N-protein-coding sequence. Following the N-protein gene, the 3′ untranslated region (UTR) was identified to be 298 nucleotides, followed by a stretch of polyadenylation tail.. The nonstructural NS2 gene, located immediately downstream of RNA polymerase gene 1b, has been shown to be heterogeneous in coronavirus. In MHV JHM variant Wb1, a large portion of the 5′ end of the NS2 gene is deleted, and as a result, the NS2 protein is not expressed (29). However, in SDAV the NS2 nonstructural-protein gene was identified to code for a polypeptide of 274 amino acids.. Similar to the NS2 gene, the hemagglutinin-esterase (HE) ...
By JACOB MARROCCO The Rhode Island Department of Health offered an update Friday morning on the results of its first round of coronavirus antibody testing, noting much higher numbers for Hispanic and Black participants. Dr. Philip Chan, the departments
Some blood-sample studies have suggested the number of people with coronavirus antibodies are "orders of magnitude" greater than those testing positive in conventional tests, DeSantis said during a visit to Dolphin Pointe Health Care, a skilled nursing facility adjacent to Jacksonville University. Standard tests also require days of waiting to learn the results, and sometimes weeks. ...
The Centers for Disease Control and Prevention (CDC) confirmed the first U.S. case of a new coronavirus on Jan. 21, in the state of Washington. The CDC and the World Health Organization are working to stem the outbreak of the coronavirus (2019-nCoV) believed to have begun in Wuhan, China. The U.S. is the fifth country outside of China to report cases of the virus. The AFT has developed a fact sheet outlining CDC guidelines that will help healthcare workers to recognize symptoms of the virus and recommended precautions healthcare workers should take to protect themselves and their community.
The Philippines introduced a more aggressive testing programme for the coronavirus on Tuesday to locate what it said could be as many as 15,000 unknown infections, despite having implemented some of Asia
In line with County and State recommendations, City Staff are postponing our own meetings, events, and gatherings, especially those that host high-risk populations at least till the end of March. Staff are contacting those affected directly, and updating our website accordingly. We will continue to publish City news related to Coronavirus on this page and recommend all residents visit the County website for COVID-19 directives. You can click here to sign up to receive email or text updates when new information is available from the County.. ...
Get to know more about the unprecedented reaction of Global 2 Ethylhexyl Methacrylateplayers analysis and their strategies. Impact of coronavirus on Consumer Spending to create intense volatility and speculative pricing bringing imbalance in demand and supply curve.
Whats further perplexing about the situation is the fact that it took two months for the full gene sequence of this mutated coronavirus strain to be released by the National Institute of Virology, which received it a while back after it was collected from a patient in Kerala.. Why it took this Indian government agency so long to release it has created more questions than there are answers as to just how serious this situation truly is. Even more concerning is a warning put out by the South China Morning Post, admittedly a communist Chinese government propaganda outlet, that theres much more to come in the area of mutations.. "[T]here is real concern growing that thousands of strains sampled and sequenced are just the tip of the iceberg - and great variety increases the risk that new strains will require new vaccines in the same way the flu virus does," the paper reported.. Even so, the race is on to release one, two, or even seven, in the case of billionaire eugenicist Bill Gates, different ...
This topic has 1 study abstract on Toona sinensis indicating that it may have therapeutic value in the treatment of Coronaviridae Infections, and SARS
North Korea introduced tougher prevention measures against the novel coronavirus on Tuesday, state media reported, after it locked down the border town of Kaesong to tackle what could be its first publicly confirmed case of the respiratory disease.
With Coronavirus on the forefront of many minds, independent researchers Dawn Lester & David Parker join THC to talk about their deep dive into the history of Western medicine, germ theory, viruses, and outbreaks. It was a long multi-year journey that has culminated in their great work, What Really Makes You Ill? Why Everything You Thought You Knew About Disease Is Wrong, a nearly 800 page detailed breakdown of everything theyve found and the conclusions the data brought them to.. https://www.thehighersidechats.com/dawn-lester-david-parker-what-really-makes-us-ill-germ-theory-the-four-factors/. ...
Get to know more about the unprecedented reaction of Betulinic Acid Market Researchplayers analysis and their strategies. Impact of coronavirus on Consumer Spending to create intense volatility and speculative pricing bringing imbalance in demand and supply curve.
TY - JOUR. T1 - Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. AU - Vennema, Harry. AU - Poland, Amy. AU - Foley, Janet E. AU - Pedersen, Niels C. PY - 1998/3/30. Y1 - 1998/3/30. N2 - Feline infectious peritonitis virus (FIPV) strains from six cats and three different geographic areas were compared genetically with feline enteric coronavirus (FECV) isolates obtained from cats inhabiting the same environments. Sequence comparisons were made from 1.2- to 8.9-kb segments on the 3 end of the genome. FECV/FIPV pairs from the same catteries or shelters were 97.3-99.5% related but were genetically distinct from FIPV and FECV strains obtained from cats living in geographically distinct environments. The high genetic similarity between FECVs and FIPVs from the same environment strongly suggested a common ancestry. Based on the presence of deletion mutations in the FIPVs and not in the FECVs, it was concluded that FIPVs evolved as mutants of FECVs. The ...
Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.
Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…
The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory disease and systemic dysfunction that may eventually lead to the death of the patients. After MERS-CoV was first diagnosed in the South Korea, in May 2015, it affected 186 individuals and claimed 37 lives in short span of time (case fatality rate = 19.9%). Compared to MERS-CoV in the Middle East, MERS-CoV in South Korea appeared to be more transmissible, and induced multiple human-to-human transmission. These knowledge gaps caused the failure of early prevention, and disseminated MERS-CoV brought out a great loss of lives and economy. The MERS-CoV outbreak revealed the potential weakness of public health system in South Korea, and promoted the reestablishment of preventive strategies for imported infectious diseases. In these regards, we analyzed the potential for additional import of re-emerged and emerging infectious diseases, such as dengue fever, malaria, chikungunya fever and hepatitis A, from Africa ...
Rapid-response platforms are needed to control newly emerging virus pathogens. MERS-CoV likely emerged in the Middle East from exotic animals, perhaps bats, although the exact timing and origins of this pathogen in human populations remains unclear and is under study. MERS-CoV has caused 54 deaths at the time of writing (∼50% mortality), including documented instances of human-to-human transmission (3, 8). Therefore, the epidemic potential of MERS-CoV is high and its biology, life cycle, gene function, and pathogenic mechanisms clearly warrant additional study.. Developing full-length infectious cDNAs of emerging RNA viruses is assisted by the availability of high-throughput sequencing, gene synthesis, and the use of class II/IIS restriction endonucleases that allow seamless assembly of consensus synthetic cDNA fragments into full-length infectious cDNAs. In this instance, we synthesized a molecular clone from the published sequence, assembled full-length genomes, and isolated recombinant ...
On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.
WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...
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The Cornell University Animal Health Diagnostic Center (AHDC) has seen a rise in the diagnosis of equine enteric coronavirus cases since initial outbreaks were investigated starting in 2010. The AHDC Veterinary Support Services veterinarians are attributing this increase in equine enteric coronavirus in our area of the Northeast to improved awareness of the disease and
The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...
Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its "family tree".. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...
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LAGOS State Government, alerted its indigenes traveling to other parts of the world with confirmed cases of coronavirus infections - a severe, life-threatening respiratory disease - to take adequate precautions to protect themselves from the infection. The coronavirus known as Middle East Respiratory Syndrome Coronavirus (MERS-CoV, is currently ravaging countries in the Middle East and…
In a surprise finding, South Korean researchers observed point mutations in MERS-CoV isolates that rendered the virus less virulent as the outbreak in that country spread last year, a finding that may have ramifications for vaccine development, according to a study today in mBio.. The scientists isolated 13 viral genomes from 14 patients infected with MERS-CoV (Middle East respiratory syndrome coronavirus) in late spring through July last year in South Korea. They found that 12 of the genomes had two specific mutations (I529T and D510G) in the receptor-binding domain (RBD) of the viruss spike protein.. They also determined that the mutations impaired viral fitness and virulence, rather than making the virus more virulent, or capable of causing severe disease.. "This is an interesting strategy of coronavirus evolution to survive in nature and live together with the new host. The virus may tune down its power to attack for the sake of longer survival in the new host," said principal investigator ...
WHO immediately alerted all its Member States about the novel coronavirus and has been leading the coordination of and providing guidance to health authorities and technical health agencies. A joint Republic of Korea-WHO high-level mission was undertaken in June 2015 with the aim of gaining information and reviewing the situation. The team has also assessed the public health response efforts and provided its recommendations.. The IHR Emergency Committee convened by the WHO Director-General held its ninth meeting regarding MERS-CoV on 16 June 2015. The Committee concluded that the conditions for a public health emergency of international concern have not been met. WHO/Europe will continue to provide input to all aspects of this response, including participating in risk assessment, providing support to Member States that have had cases, supporting surveillance and laboratory capacities and disseminating information.. WHO/Europe in collaboration with the European Centre for Disease Prevention and ...
Every virus needs a catchy name, and now the new coronavirus linked to the Middle East that has infected 40 people and killed half of them has one: Middle East Respiratory Syndrome Coronavirus or (MERS-CoV). Various scientists have been calling it MERS,
A senior World Health Organization official announced that the United Nations agency would convene an emergency committee to plan for a possible escalation in illnesses caused by the Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. Dr. Keiji Fukuda, assistant director general for health...
A new study suggests that the Middle East Respiratory Syndrome coronavirus (MERS-CoV) develops mutations that make the virus less virulent during an outbreak rather than more virulent. The study, published this week in mBio, an online open-access journal of the American Society for Microbiology, has implications for vaccine development.
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 October-4 November 2017 and includes updates on chikungunya, Legionnaires disease, malaria, Middle East respiratory syndrome coronavirus (MERS-CoV), influenza A(H7N9), plague, poliomyelitis, seasonal influenza and West Nile virus. ...
Robert Roos at CIDRAP has an excellent overview of the day: MERS surge continues; April cases top past 2 years total. Excerpt: The April surge of MERS-CoV (Middle East respiratory syndrome coronavirus) cases continued today with a report of 16...
Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.
The Middle East Respiratory Syndrome Coronavirus, better known as MERS, may be an airborne virus, according to an observation paper published Tuesday in the journal mBio.. 12NewsNow Story
The strain of the Middle East respiratory syndrome coronavirus currently circulating in South Korea is highly similar to the one in the pathogens namesake region.. 0 Comments. ...
CDC Coronavirus: Coronaviruses are common throughout the world. They can infect people and animals. Five different coronaviruses can infect people and make them sick. They usually cause mild to moderate upper-respiratory illness.
Russia reported 9,200 new confirmed cases of the novel coronavirus on Saturday, down from 10,598 new cases reported the previous day.
The U.S. Centers for Disease Control and Prevention confirms the first U.S. case of the newly-emerging Middle East Respiratory Virus or MERS within U.S. borders. Jillian Kitchener reports.
Lane TE, Hosking MP. The pathogenesis of murine coronavirus infection of the central nervous system. Crit Rev Immunol. 2010;30(2):119-30. PMID: 20370625...
The main symptoms are a fever, a dry cough, shortness of breath, or trouble breathing. MERS may also cause a headache, muscle aches, a sore throat, fatigue, and diarrhea or there may be no symptoms at all. For some people the symptoms get worse quickly, so they may need to stay in the hospital. The incubation period-the time from when a person is first exposed to MERS until symptoms appear-is usually 5 to 6 days, but it may be as long as 14 days.. If you have symptoms of the illness, do not go to a health facility without calling first. Calling first will help the health care team take better care of you and protect others from the illness. ...
Dr. Thoma walks us through the deadly MERS outbreak that has finally hit the US. So far its limited to Indiana. Far too little is known about the syndrome.
The Automobile Association predicts a decrease of between 9 and 19 cents a litre for petrol, 55 cents a litre for diesel, and 68 cents for illuminating paraffin on the back of the effect of the coronavirus on global trade.. The petrol price adjustment is expected to be announced soon- with the price change taking effect at midnight on Tuesday.. There are concerns that the coronavirus outbreak - centered on Wuhan Province in China - could further damage an already fragile global economy - leading to a decrease in demand for oil.. The death toll from the outbreak stands at over 2 800 people with around 83 000 infections.. AA spokesperson Layton Beard, however, says the depreciation of the Rand could impact and limit the decrease.. He says: "International petroleum prices this week suffered one of their steepest plunges in recent years as coronavirus fears impacted global economic activity. We are still very concerned about the depreciation of the rand against the US dollar and its something we ...
Ive gone through a lot of introductions to this post but maybe this is the most honest one: I am scared. Quite scared, actually. My chances of catching COVID-19 are actually quite low, and my chances of surviving it if I do are quite high, and Im still scared. What if I get into a car accident and have to go to the ER? Will they have a bed for me? Will I leave with coronavirus? What are my pregnant friends going to do? What is anyone over 70 going to do? My goal, and the goal of everyone on the LW staff, and I assume most everyone whos participated in all the coronavirus threads, has been to figure out what is happening and what we can do about it. Weve already done a lot. Posts like Seeing the Smoke [https://www.lesswrong.com/posts/5okDRahtDewnWfFmz/seeing-the-smoke] got coronavirus on peoples radar faster than it otherwise would have been, aided by the numerous modeling threads [https://www.lesswrong.com/posts/KJBQ7GiyvFTBnSEEC/growth-rate-of-covid-19-outbreaks] backing it up. The Quarantine
Currently, no protective vaccine is available against the coronavirus strain responsible for Middle East Respiratory Syndrome (MERS). The need for such a vaccine is underlined by the current outbreak of the disease in South Korea, which has led to the infection of over 150 people and has already caused several deaths. Two years ago, a team of researchers led by Professor Gerd Sutter, who holds the Chair of Virology at LMUs Institute for Infectious Diseases and Zoonoses, reported that it had developed a candidate vaccine directed against the MERS-CoV. Further preclinical tests have confirmed its efficacy, as the team now reports in the "Journal of Virology". These results lead the way for Phase I clinical trials, which will determine how well the vaccine is tolerated by human subjects.. The vaccine candidate, named MVA-MERS-S, was developed by Sutters group in collaboration with colleagues based at Marburg University and the Erasmus Medical Center in Rotterdam. It is based on the use of a ...
OSLO, March 14 (Reuters) - Norway recorded its second death from the coronavirus on Saturday, Oslo University Hospital said on Twitter.. Norways first case of the virus was confirmed on Feb. 26, since when the total number of infected people has risen to 907, according to the official count by the Norwegian Institute of Public Health fhi.no, updated on Saturday. (Reporting by Victoria Klesty; Editing by Catherine Evans) ...
US - The number of pig farm samples that are confirmed positive for porcine epidemic diarrhoea virus (PEDV) in the last week was 16, while no premises were confirmed with porcine deltacoronavirus (PDCoV) or the dual infection (PEDV and PDCoV).
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Ascension Seton, Baylor Scott & White Health and St. Davids HealthCare are currently participating in a national study, to determine if plasma from recovered COVID-19 patients may benefit individuals currently hospitalized with severe or life-threatening cases of the virus. To date, there is no proven therapy for individuals who are diagnosed with COVID-19.. After someone is infected with a virus like COVID-19 and recovers, their blood contains antibodies that their immune system produced to help them fight off the virus. By infusing this plasma into patients who are facing severe cases of COVID-19, their immune system might be able to fight the virus more effectively.. Recent examples of this approach have occurred during outbreaks of coronaviruses like SARS-1 and Middle East Respiratory Syndrome (MERS), but additional clinical data-and more plasma donations-are needed to determine efficacy in treating COVID-19.. The success of the study hinges on the continued collection of plasma from ...
Via Dr. P. Phillips Hospital in Orlando, Florida: Orlando Health Statement on MERS. Excerpt: Orlando Healths Dr. P. Phillips Hospital is currently treating a patient who has tested positive for the Middle East Respiratory Syndrome or MERS-CoV. The patient is...
Federal health officials reported over the weekend that the virus that causes Middle East respiratory syndrome, or MERS, had spread from one person to another for the first time in the U.S.
There is growing concern about the outbreak of Middle East Respiratory Syndrome (Mers): What is it? Am I at risk in the UK? What are the symptoms?
The team members at Dr. Phillips Hospital who were showing symptoms of MERS, or Middle East Respiratory Syndrome , tested negative for the virus, officials said.
The Middle East Respiratory Syndrome, or MERS, has infected more than 500 people since it was first identified in 2012. About 30 percent of those who contract it die. The steep increase in the number of cases in recent months, and the fact that people in Asia, Europe and North America have come down with the virus, have raised concern that the situation may worsen. VOAs Carol Pearson looks at how health officials are preparing for pandemics.
A scary new virus is roaming the globe. Its called Middle East Respiratory Syndrome, or MERS. The first confirmed case in the U.S. was reported ...
The Centre for Health Protection (CHP) of the Department of Health (DH) today (February 1) reported the test results of two suspected cases of Middle East Respiratory Syndrome (MERS), and again urged the public to pay special attention to safety during travel, taking due consideration of health risks of the places of visit. ...
Florida-based grocery chain Publix, which has stores in the Carolinas, announced it will install plexiglass barriers to protect its cashiers, joining other retailers that are installing the shields to protect employees and customers from a coronavirus infection.
COVID-19 Risk & Immunity Report is a DNA-Based assessment of your immune response and susceptibility to coronavirus infection. For more information call at 1800-102-4595
The number of people in intensive care units (ICU) for coronavirus infection in France fell slightly for the first time since the start of the epidemic, but the number of people dying in nursing homes jumped by more than 50 percent over two days, health m... ...
Earnings for engineers vary significantly by specialty. Even so, as a gaggle engineers earn some of the highest average beginning salaries among these holding
时间系列程序包括:数据绘图,自相关,部分自相关,在进行自回归移动平均(Box-Jenkins type) 模型选择、估计参数、区别及预测时提供帮助。这一程序支持建立公式模型(能为你应用W-数据技术选择模型提供帮助。),支持对模型参数的估计以及模型使用的预测(提供三种预测方法)。在文件中,这一预测可以通过数字形式演示和获取 ...
Between 13 and 14 March 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. One of these reported cases is linked to the MERS-CoV outbreak currently occurring in a hospital in Buraidah city.
Between 14 and 20 April 2015, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 1 death. Cases are listed by date of reporting, with the most recent case listed first.
In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...
Clinicians, laboratories and public health practitioners should be aware that many Muslims from Australia will travel to Saudi Arabia in October to undertake the Hajj between 13 and 18 October, and may travel at other times to undertake the Umrah. Health professionals should be aware of the possibility of cases in travellers returning from the Hajj which ends on 18 October 2013.. The Saudi Ministry of Health recommends that elderly people and those with chronic diseases such as heart disease, kidney disease, respiratory disease and diabetes, as well as patients with congenital and acquired immune deficiency diseases, cancer patients, pregnant women and children, defer travel to Saudi Arabia for the Umrah and Hajj this year.. WHO advises that that pre-existing major medical conditions (e.g. chronic diseases such as diabetes or chronic bronchitis, immunodeficiency) can increase the likelihood of medical problems, including MERS-CoV infection, during travel; thus, pilgrims should consult their ...
Looking for online definition of Coronavirus infections in the Medical Dictionary? Coronavirus infections explanation free. What is Coronavirus infections? Meaning of Coronavirus infections medical term. What does Coronavirus infections mean?
Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis. ...
Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis. ...
Cell-mediated immunity is thought to play a decisive role in protecting cats against feline infectious peritonitis (FIP), a progressive and lethal coronavirus disease. In view of the potential of DNA vaccines to induce cell-mediated responses, their efficacy to induce protective immunity in cats was evaluated. The membrane (M) and nucleocapsid ... read more (N) proteins were chosen as antigens, because antibodies to the spike (S) protein of FIP virus (FIPV) are known to precipitate pathogenesis. However, vaccination by repeated injections of plasmids encoding these proteins did not protect kittens against challenge infection with FIPV. Also, a prime boost protocol failed to afford protection, with priming using plasmid DNA and boosting using recombinant vaccinia viruses expressing the same coronavirus proteins. Because of the role of IL-12 in initiating cell-mediated immunity, the effects of co-delivery of plasmids encoding the feline cytokine were studied. Again, IL-12 did not meet expectations ...
Background Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS) outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods. Methods The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods. Results The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of
A collaborative team from The University of Texas Medical Branch at Galveston, Saudi Arabia and Canada developed a potent and safe vaccine that protects against the deadly Middle East respiratory syndrome, or MERS.
Comments, concepts and statistics about Healthcare worker infected with Middle East respiratory syndrome during cardiopulmonary resuscitation in Korea, 2015.
What causes FIP?. FIP develops as a result of an adverse reaction to the feline enteric coronavirus. The feline enteric coronavirus is shed by infected animals in feces. An infected cat may shed some of the virus in feces, and when another cat comes along to investigate, the virus infects the new cat through the mouth and nose. When the cat is infected, the virus may be destroyed by the immune system or it may mutate, allowing it to take advantage of the hosts body and live undetected. This leads to the hosts body becoming infiltrated with the virus, causing pyogranulomas. Some cats infected by feline enteric coronavirus present with non-threatening flu like symptoms, and some develop FIP.. ...
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The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...
Summary_MERS-CoV_15Apr15_final.pdf (573.1 KB) Recent evolution patterns of the Middle East respiratory syndrome coronavirus (MERS-CoV) Mazin A. Barry MD1, Sarah S. Al Subaie MD[2], Ali M. Somily MD[3], Abdulaziz A. Bin…
Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...
Title: Two New Cases of MERS Coronavirus reported in Saudi Arabia.. Subject: Middle East Respiratory Syndrome Coronavirus in Saudi Arabia, daily update.. Source: Saudi Arabia Ministry of Health, full page: (LINK).. Code: [ ]. _____. MOH: 2 New Confirmed Coronavirus Cases Recorded. ___ New Cases Reported: [Sex, Age, Citizenship, Resident in, Health Status, Note ...
During the course of this project, we witnessed the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). MERS-CoV is associated with severe respiratory disease and has an exceptionally high case fatality of approximately 40%. Initially, it was not known either how efficiently the MERS-CoV could replicate on the human airway epithelium or whether any measures were available to inhibit MERS-CoV replication in the human airway epithelium, indeed, even the nature of the target cell(s) was unknown. Since primary HAE-cultures were immediately at our command, we could participate in a number of international studies. We were the first to demonstrate that MERS-CoV can efficiently replicate on the primary human epithelium, which highlights its zoonotic potential (2).. Importantly, the treatment of MERS-CoV-infected HAE-cultures with interferon-alpha and interferon-lambda significantly reduced viral replication. Hence, this strategy opens up a therapeutic option for MERS-CoV patients ...
We establish new minimum protein requirements for the formation of double-membrane vesicles (DMVs), a prototypic type of virus-induced membrane structure that also plays a role in the replication of other viral pathogens. We demonstrate a direct link between membrane remodelling and viral polyprotein processing and reveal the likely DMV biogenesis mechanism.. This work was done in close collaboration between the departments of Molecular Virology and Cell and Chemical Biology at the LUMC.. Oudshoorn, D., Rijs, K., Limpens, R., Groen, K., Koster, A.J., Snijder, E.J., Kikkert, M. and Barcena, M., "Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus Nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral Rna Replication" (2017) MBio, 8, 6.. ...
Since the Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in Saudi Arabia in 2012, there have been more than 2,400 confirmed cases of the infection, resulting in greater than 800 deaths - an alarming fatality rate of 35 percent. For this reason, researchers have been eager to identify any risk factors that contribute to the development of severe or lethal disease. Current clinical evidence points to diabetes as a major risk factor in addition to other comorbidities including kidney disease, heart disease, and lung disease.. Researchers from the University of Maryland School of Medicine (UMSOM) and the Johns Hopkins University School of Medicine have demonstrated in a new study, published earlier this week in the Journal of Clinical Investigation Insights, how diabetes contributes to mortality from MERS-CoV infections, and the finding could shed light on why other respiratory illnesses like the flu or pneumonia might strike those with diabetes more severely.. They ...
Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to estimate rates of morbidity and mortality and to examine predictors of severity among participants with 2009 H1N1 infection. In 2011, as surveillance indicated that 2009 H1N1 virus was co-circulating with other seasonal influenza A and B viruses worldwide, the protocol was expanded to include other influenza A subtypes and influenza B viruses. The current version of the protocol (released in August 2013) further broadens the scope of this observational study. With the recognition that novel respiratory viruses other than novel influenza A viruses, e.g., Middle East Respiratory Syndrome Coronavirus (MERS-CoV), could become prevalent and of major public health importance, the objectives of this protocol have been expanded ...
The University of Queenslands Australian Institute for Bioengineering and Nanotechnology (AIBN) has appointed a new director following an international search.. Professor Alan Rowan will join UQ in January, taking over from AIBNs inaugural director, Professor Peter Gray.. UQ Vice-Chancellor and President Professor Peter Høj said Professor Grays leadership since 2003 had helped position AIBN as a major research institute of international standing, employing almost 500 people.. "Weve seen significant success stories, including Nanopatch vaccine technology, the manufacture of an antibody used in world-first human Hendra virus clinical trials, and collaboration between AIBN and American researchers to tackle the growing global threat of Middle East respiratory syndrome coronavirus (MERS-CoV)," Professor Høj said.. "The nanotechnology research at AIBN has had broad reaching application, from ground-breaking advancements in green energy technologies to targeted drug delivery.. Professor Rowan ...
Zymo Research Corp. announced on Monday that it released its DNA/RNA Shield, a viral inactivation solution that can help to transport viruses including Ebola and Middle East Respiratory Syndrome coronavirus (MERS-CoV).
People with diabetes are at a higher risk of various complications, including worse respiratory diseases. One of the most dreaded lung diseases is the Middle East respiratory syndrome coronavirus (MERS-CoV), which emerged in Saudi Arabia in 2012.
Clinical signs may worsen with secondary bacteria infection. Infection in adults is normally subclinical, the exception being ... Bovine coronavirus (BCV) is as a member of the Coronaviridae family which are enveloped, single-stranded, positive-sense RNA ... Infection causes 'calf enteritis' and contributes to the 'enzootic pneumonia complex' in calves. It can also cause 'winter ... Infection normally occurs in calves between the ages of one week and three months. Gastrointestinal signs include profuse ...
... is an order of viruses with animal and human hosts (MERS-CoV and SARS-CoV). It includes the families Coronaviridae ... co-terminal nested set of subgenomic mRNA's during infection. This group consists of viruses which have positive-sense, single- ... which included the Coronaviridae and Roniviridae (the large nidoviruses) and those with small genomes (the small nidoviruses)-a ...
... coronaviridae infections MeSH C02.782.600.550.200 --- coronavirus infections MeSH C02.782.600.550.200.325 --- enteritis, ... deltaretrovirus infections MeSH C02.782.815.200.260 --- enzootic bovine leukosis MeSH C02.782.815.200.470 --- htlv-i infections ... rubulavirus infections MeSH C02.782.580.600.680.500 --- mumps MeSH C02.782.580.830 --- rhabdoviridae infections MeSH C02.782. ... cardiovirus infections MeSH C02.782.687.207 --- common cold MeSH C02.782.687.359 --- enterovirus infections MeSH C02.782. ...
Human infection by SARS coronavirus appears to be limited to the respiratory tract where infection of susceptible cells leads ... Coronaviridae 19. Coronaviridae Coronaviruses Focus on Coronaviruses Viralzone: Coronaviridae Virus Pathogen Database and ... Coronaviridae is a family of enveloped, positive-stranded RNA viruses. The viral genome is 26-32 kb in length. Virions are ... Recent outbreaks have resulted from nosocomial infections and have been geographically limited to the Saudi peninsula (the 2015 ...
Infections show a seasonal pattern with most cases occurring in the winter months. Betacoronavirus RNA virus Human coronavirus ... Coronaviridae Lau, Susanna K. P.; Lee, Paul; Tsang, Alan K. L.; Yip, Cyril C. Y.; Tse, Herman; Lee, Rodney A.; So, Lok-Yee; Lau ... Both viruses can cause severe lower respiratory tract infections, including pneumonia in infants, the elderly, and ... family Coronaviridae, order Nidovirales). Four HCoV-OC43 genotypes (A to D), have been identified with genotype D most likely ...
Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775-779. [PMC free article] [PubMed] Gerna, G., E. ... in the family Coronaviridae, of the order Nidovirales. Along with Human coronavirus OC43, it is responsible for the common cold ... An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin. Infect. Dis. 36:985-989. [PubMed] Woo, P. C. Y ... Seroepidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Am. J. Epidemiol. 94:43- ...
The total length of this is about 28,000 nucleotides and, like all members of the Coronaviridae, toroviruses have a complex ... Supportive treatment may be given to prevent dehydration and secondary infections. Control relies on good biosecurity measures ... Torovirus is a genus of viruses in the order Nidovirales, in the family Coronaviridae, in the subfamily Torovirinae. They ... Torovirus particles share characteristics with other members of the Coronaviridae family; they are round, pleomorphic, ...
Coronavirus infection of the intestinal villi makes the cells more susceptible to parvovirus infection. This causes a much more ... Canine coronavirus is a virus of the family Coronaviridae that causes a highly contagious intestinal disease worldwide in dogs ... Yachi A, Mochizuki M (2006). "Survey of dogs in Japan for group 2 canine coronavirus infection". J Clin Microbiol. 44 (7): 2615 ... Pratelli, A. (2005). "Canine Coronavirus Infection". Recent Advances in Canine Infectious Diseases. Retrieved 2006-06-25. ...
Laboratory investigation may be useful in diagnosing associated bacterial infections, however. Viral infections are commonly of ... Only one family of enveloped viruses causes gastroenteritis (Coronaviridae). All other viruses associated with gastroenteritis ... A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... [email protected] List of latent human viral infections Pathogenic bacteria Taylor, M.P.; Kobiler, O.; Enquist, L. W. (2012). " ...
... chronic persistent infection, whereas BVD is an acute infection. Arteriviruses are small, enveloped, animal viruses with an ... Torovirus is a genus of viruses within the family Coronaviridae, subfamily Torovirinae that primarily infect vertebrates and ... ASFV is endemic to sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs, bushpigs ... Some strains can cause death of animals within as little as a week after infection. In other species, the virus causes no ...
Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats..J Gen ... Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae German Research Foundation (Coronavirus Consortium). ...
Infection of macrophages by FIPV is responsible for development of a fatal granulomatous vasculitis, or FIP (see granuloma). ... This virus is part of the Alphacoronavirus 1 species of the Alphacoronavirus genus belonging to the Coronaviridae family of ... Type I, that can be defined as 'FECV that could mutate to FIPV type I', is responsible for 80% of the infections. Typically, ... Felin coronavirus infections are therefore sialic acid dependant. Kittens born from mothers carrying FECV are protected from ...
Infections. 1 (11): e35. doi:10.1038/emi.2012.45. PMC 3630921 . PMID 26038405. Zaki, Ali M.; Van Boheemen, Sander; Bestebroer, ... Coronaviridae. ...
A new case of confirmed infection) May 12, 2013 social-sante.gouv.fr "Novel coronavirus infection - update". World Health ... Coronaviruses are species of virus belonging to the subfamily Coronavirinae in the family Coronaviridae, in the order ... The virus was officially named the SARS coronavirus (SARS-CoV). The epidemic resulted in over 8,000 infections, about 10% of ... Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae German Research Foundation (Coronavirus Consortium). ...
It refers to this order's production of a 3' co-terminal nested set of subgenomic mRNA's during infection. Animal viruses Human ... Betacoronaviruses are one of four genera of coronaviruses of the subfamily Coronavirinae in the family Coronaviridae, of the ... Coronaviruses Viralzone: Betacoronavirus Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae. ... "Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections". New England Journal of Medicine. 368 (26): 2487-94 ...
For example, they are a source of rabies fatalities in the United States which results in one to two infections per year in ... Family Coronaviridae. In: Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. San Diego, CA: ... In addition, bats are known to have persistent viral infections at a rate higher than other mammals. This is believed to be due ... Krüger DH, Schonrich G, Klempa B. Human pathogenic hantaviruses and prevention of infection. Hum Vaccin. 2011;7:685-93. New ...
May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Coronaviridae (fugleinfluenza). *Picornaviridae (polio). Gruppe V - Negativt polariseret enkeltstrenget RNA-virus (-ssRNA)[ ... infection has an unexpected up side, at least in mice, since it protects them against bacterial infections..." ... Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Frontiers in Microbiology ...
The infection of cells with this altered virus elicits a specific lactogenic immune response against the heterologous protein. ... TGEV belongs to the coronaviridae family, genus Alphacoronavirus, species Alphacoronavirus 1. It is an enveloped virus with a ... Transmissible gastroenteritis coronavirus (TGEV) is a virus belonging to the family Coronaviridae, genus Alphacoronavirus, ...
Proper infection and production of progeny requires that the cell be in replication, as it is during replication that the ... Examples of this class include the families Astroviridae, Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae, ...
Further studies have shown that in the first twenty-four hours after infection of a macrophage there is very rapid virus ... Also included in the nidovirales order are the coronaviridae. The arteriviridae infect macrophages in animals and cause a ... of the virus include a temporary fall in the total white blood cell count that lasts for twenty-four hours after infection. ...
After infection, the entirety of the host cell's translation machinery may be diverted to the production of viral proteins as a ... and Coronaviridae). All but the arterivirus family contain at least one human pathogen; arteriviruses are known only as animal ... The first proteins to be expressed after infection serve genome replication functions; they recruit the positive-strand viral ... Saxena, Pooja; Lomonossoff, George P. (4 August 2014). "Virus Infection Cycle Events Coupled to RNA Replication". Annual Review ...
... shown that griffithsin binds to the SARS-CoV spike glycoprotein to inhibit entry of the SARS virus and thus inhibit infection. ... Vitro Activity and In Vivo efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae ...
It then injects its DNA or RNA into the host to initiate infection. The cell membrane of the host cell invaginates the virus ... Examples of this class include the families Coronaviridae, Flaviviridae, and Picornaviridae. The negative-sense RNA viruses and ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ...
Co-infections are also a common occurrence in animals afflicted with CaCV. Canine distempter and parvovirus (genotype 2) were ... CaCV is not to be confused with canine coronavirus, another diarrhea-causing agent within the family Coronaviridae, or porcine ... Two dogs passed away within a week of infection while the others were ill but able to recover. One of the bodies underwent ... Within the group of dogs that tested positive for CaCV, 68% of them had other co-infections of varying illnesses. There have ...
Družina: Coronaviridae › Poddružina: Coronavirinae › Genus: Betacoronavirus[51] › Species: Betakoronavirus 1 (običajno ime ... Mohammed Rasooldeen, Fakeih: 80% drop in MERS infections, Arab News, Vol XXXIX, Number 183, Page 1, 6 June 2014. ... WHO: Novel coronavirus infection - update (13 February 2013) (accessed 13 February 2013) ... "Scientists race to understand deadly new virus: SARS-like infection causes severe illness, but may not spread quickly" ...
Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... At that point, the infection will persist indefinitely. In most viruses, DNA is transcribed into RNA, and then RNA is ... As a result, cells such as neurons are very resistant to infection and transduction by retroviruses. This gives rise to a ... Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of ...
Coronavirus Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. To Top ... Proportion of Patients with COVID-19 who Develop Shock, Secondary Organ Failure, or Secondary Infection Over Time to Day 28 [ ... Convalescent questionnaires and biologic samples will be collected at 3-month intervals up to Month 12 after infection symptom ... detailed immunophenotyping to provide a comprehensive picture of immune changes that occur throughout the course of infection. ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Respiratory Tract Infections. Respiratory Tract ... Covid-19 Corona Virus Infection SARS-CoV 2 Drug: Oxytocin Drug: Standard of Care Phase 2 ... Introduction There are currently no treatments with demonstrated efficacy for COVID-19 infection. Epidemiological evidence ... Coronavirus Infections. Severe Acute Respiratory Syndrome. Virus Diseases. ...
Coronavirus Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Vaccines. ... Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med. 2013 Jun 27;368(26):2487-94. doi: ... Participants with a significant infection or known inflammation.. *History of relevant cardiovascular disorders or evidence of ... An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science. 2016 Jan 1;351( ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... and may be the main clinical manifestations of the infection. Olfactory dysfunction could result from infection of the ... Coronavirus Infection Severe Acute Respiratory Syndrome Sars-CoV2 Other: Nasal swab Other: Taste and olfactory function ... the direct infection of olfactory sensory neurons or neural stem cells of the olfactory mucosa, ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... MedlinePlus related topics: Coronavirus Infections Drug Information available for: Hydroxychloroquine Hydroxychloroquine ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Coronavirus Infection Prevalence Biological: Anti-SARS-CoV-2 IgT seropositivity Not Applicable ... Serological Response to Infection [ Time Frame: through study completion, an average of 4 hours ]. To study the serum ... All of the results (detection of cases of infection, particularly those that have not experienced symptoms, estimation of the ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation (AVoCaDO). The ... MedlinePlus related topics: Coronavirus Infections Vitamin C Drug Information available for: Ascorbic acid Sodium ascorbate ... Coronavirus Infections. Severe Acute Respiratory Syndrome. Hypoxia. Signs and Symptoms, Respiratory. Signs and Symptoms. ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Infection. Communicable Diseases. Coronavirus Infections. Severe Acute Respiratory Syndrome. ... Coronavirus Infection Drug: Hydroxychloroquine Sulfate Drug: Azithromycin Drug: Chloroquine Sulfate Phase 3 ... Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection (WU352). The safety and scientific ...
Coronavirus Infections. Virus Diseases. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. To Top ... MedlinePlus related topics: Coronavirus Infections Rehabilitation Genetic and Rare Diseases Information Center resources: ...
Coronavirus Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. To Top ... Scientists are worried that MERS may spread and cause more infections. There are no vaccines or treatments for MERS right now. ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Lung Injury. Respiratory Tract ... As of March 13, 2020, more than 145,000 cases of 2019-nCoV infection have been confirmed with 5,500 deaths worldwide. As of ... Coronavirus Infections. Severe Acute Respiratory Syndrome. Respiratory Distress Syndrome, Newborn. Respiratory Distress ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Severity of COVID-19 infection [ Time Frame: 12 weeks ]. Rate of severe COVID-19 infection in healthcare works (hypoxia in ... COVID-19 Corona Virus Infection Wuhan Coronavirus Prophylaxis Healthcare Worker Sars-CoV2 Hydroxychloroquine Drug: ... The secondary objectives are number of days absent from work due to symptomatic COVID-19 infection and rate of severe disease ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Coronavirus Infections. Nitric Oxide. Severe Acute Respiratory Syndrome. Syndrome. Disease. Pathologic Processes. Respiratory ... Intubated patients admitted to the intensive care unit with confirmed SARS-CoV-2 infection and severe hypoxemia will be ... Severe acute respiratory syndrome (SARS-CoV2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is ...
Orthomyxoviridae Infections. RNA Virus Infections. Respiratory Tract Infections. Respiratory Tract Diseases. Coronaviridae ... Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of ... Outcomes of influenza A(H1N1)pdm09 virus infection: results from two international cohort studies. PLoS One. 2014 Jul 8;9(7): ... Have a local diagnosis (confirmed or suspected) of influenza, or of a targeted non-influenza viral respiratory infection*, ...
Coronaviridae Infections / diagnosis* * Coronavirus / immunology* * Coronavirus / isolation & purification * Coronavirus ...
Coronaviridae / immunology* * Coronaviridae Infections / diagnosis * Coronaviridae Infections / veterinary* * Diarrhea / ...
Categories: Coronaviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Lung Injury. Bronchodilator Agents. ... The clinical spectrum of the infection is wide, ranging from mild signs of upper respiratory tract infection to severe ... Coronavirus Infections Pneumonia, Viral Acute Respiratory Distress Syndrome Drug: Nitric Oxide Phase 2 ... Laboratory confirmed COVID19 infection defined with a positive RT-PCR from any specimen and/or detection of SARS-CoV-2 IgM/IgG ...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. ... Men are also more likely to pick up the infection in the first place and account for 60 percent of confirmed cases, according ... ACE2-expressing cells can act as home cells and are prone to SARS-CoV-2 infection as ACE2 receptor facilitates cellular viral ... The role of cathepsins in viral infection was first identified by Huang et al and they found that one cysteine proteases ...
Coronaviridae Infections, Coronavirus Disease, Coronavirus Infection, Coxsackievirus Infections, Influenza A, Parainfluenza, ... Coronaviridae Infections, Coronavirus Disease, Coronavirus Infection, Oxidative Stress, Viral Infections ... Diseases : Candida Albicans, Coronaviridae Infections, Helicobacter Pylori Infection, Influenza, Streptococcus pyogenes, Upper ... Polysaccharides from Ginkgo biloba exocarp inhibits porcine epidemic virus infection (coronaviridiae) infection in vitro.Jan 02 ...
The high mortality of weaned pigs which showed the similar clinical syptom was possibly a result of HEV and PRRSV co-infection ... The high mortality of weaned pigs which showed the similar clinical syptom was possibly a result of HEV and PRRSV co-infection ... One case of swine hepatitis E virus and porcine reproductive and respiratory syndrome virus co-infection in weaned pigs. ... One case of swine hepatitis E virus and porcine reproductive and respiratory syndrome virus co-infection in weaned pigs. ...
Coronaviridae Infections/immunology*. *Encephalitis, Viral/immunology*. *T-Lymphocytes, Regulatory/immunology*. Minor. * ...
Coronavirus Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Acetaminophen. ... MedlinePlus related topics: Coronavirus Infections Genetic and Rare Diseases Information Center resources: Severe Acute ... Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection; asplenia; recurrent severe ... infections and use of immunosuppressant medication within the past 6 months, except topical steroids or short-term oral ...
Coronavirus Infections. Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Virus Diseases. Respiratory ... MedlinePlus related topics: Coronavirus Infections Genetic and Rare Diseases Information Center resources: Severe Acute ... Hospitalized subjects, or those with an active viral infection other than possible SARS, within 2 weeks of study entry. ... Evidence of HIV or other viral infections including chronic hepatitis, or other active gastrointestinal, renal, respiratory, ...
  • Similarly, MHV-JHM infection can spread from infected murine cells (DBT or 17Cl-1) to hamster (BHK) or rabbit (RK13) cells that do not express mCEACAM1a, even though MHV-JHM cannot infect these cells ( 13 , 27 , 30 , 43 ). (asm.org)
  • These membrane whorls are postulated to be replication complexes for the virus since they appear very early (within 30 minutes) after infection. (cdc.gov)
  • The total length of this is about 28,000 nucleotides and, like all members of the Coronaviridae, toroviruses have a complex replication mechanism that includes the use of subgenomic mRNA, ribosomal frameshifting, and polymerase stuttering. (wikipedia.org)
  • Proper infection and production of progeny requires that the cell be in replication, as it is during replication that the cell's polymerases are active. (wikipedia.org)
  • Scientists are worried that MERS may spread and cause more infections. (clinicaltrials.gov)
  • We know that there are similarities between other coronaviridae SARS and MERS and COVID-19 - and this has allowed us to observe the CT changes of these patients with a comparative lens. (esicm.org)
  • However, it was later discovered that neutralization of ACE2 by recombinant antibodies does not prevent MERS-CoV infection. (wikipedia.org)
  • Bat DPP4 genes appear to have been subject to a high degree of adaptive evolution as a response to coronavirus infections, so the lineage leading to MERS-CoV may have circulated in bat populations for a long period of time before being transmitted to people. (wikipedia.org)
  • Olfactory dysfunction could result from infection of the olfactory system by SARS-CoV-2 or from inflammation induced by the virus. (clinicaltrials.gov)
  • This Phase III trial four treatment strategies non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, Participants will receive hydroxychloroquine or chloroquine with or without azithromycin. (clinicaltrials.gov)
  • Severe acute respiratory syndrome (SARS-CoV-2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is characterized by severe ventilation perfusion mismatch leading to refractory hypoxemia. (clinicaltrials.gov)
  • Intubated patients admitted to the intensive care unit with confirmed SARS-CoV-2 infection and severe hypoxemia will be randomized to receive inhalation of NO (treatment group) or not (control group). (clinicaltrials.gov)
  • At this point in the pandemic of COVID-19 infection there is no evidence that SARS-CoV-2 undergoes intrauterine or transplacental transmission from infected pregnant women to their fetuses. (greenmedinfo.com)
  • Unlike infection with the hepatitis C virus-229E, wherein virus production can continue for weeks without any expression of cytopathic effects ( 18 , 19 ), infection with SARS-CoV produces copious progeny virus particles within the first 12 h ( 10 ). (cdc.gov)
  • The aim of this study was to use scanning electron and atomic force microscopes to investigate changes in the surface topography of SARS-CoV-infected cells at late infection. (cdc.gov)
  • The results can assist in further understanding how SARS CoV interacts with infected cells at late infection. (cdc.gov)
  • Whether severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection can be asymptomatic is unclear. (cdc.gov)
  • None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS CoV in adults is rare. (cdc.gov)
  • We performed a prospective study to determine whether asymptomatic or mild infection attributable to SARS-CoV was common in HCWs in this outbreak at Prince of Wales Hospital. (cdc.gov)
  • For instance, it was shown that griffithsin binds to the SARS-CoV spike glycoprotein to inhibit entry of the SARS virus and thus inhibit infection. (wikipedia.org)
  • High titers of virus were detectable in the brain and liver of mice only during the first 3 to 12 days of infection (10 and 10 PFU/g, respectively). (bvsalud.org)
  • In vivo experiment showed that GRFT (5 mg/kg) administered intraperitoneally before virus infection could completely prevent mortality in mice challenged intraperitoneally with a lethal dose of JEV. (deepdyve.com)
  • We previously showed that Ceacam1a −/− mice are completely resistant to MHV-A59 infection (E. Hemmila et al. (asm.org)
  • RJHM can initiate infection in the brains of Ceacam1a −/− mice, but expression of mCEACAM1a increases susceptibility to infection. (asm.org)
  • The outcome of the infection is dependent on the virus strains and cell types. (cdc.gov)
  • As a result, by comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection. (osti.gov)
  • Pretreatment of murine cells with MAb-CC1 prior to inoculation with MHV-A59, MHV-JHM, and other strains blocks virus attachment and infection ( 8 , 16 , 27 , 29 , 46 ). (asm.org)
  • Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to estimate rates of morbidity and mortality and to examine predictors of severity among participants with 2009 H1N1 infection. (clinicaltrials.gov)
  • The flu (seasonal influenza) is a viral infection that can affect the entire respiratory tract, from the nose all the way down to the lungs. (healthhype.com)
  • Here, we seek to better understand how one of these antiviral factors, IFITM3, contributes to both baseline, as well as interferon-induced, antagonism of influenza A viral infection. (plos.org)
  • Somewhere in Egypt, this group of Egyptian women were comparing their scientific findings during a meeting of the newly formed Eastern Mediterranean Acute Respiratory Infection Surveillance (EMARIS) Network, a regional network for standardized, and enhanced surveillance of severe acute respiratory illness, particularly influenza, in the Eastern Mediterranean Region. (cdc.gov)
  • Following initial acute infection, a majority of infected individuals develops chronic hepatitis because HCV replicates preferentially in hepatocytes but is not directly cytopathic. (google.com)
  • Mucosal disease is a distinct, chronic persistent infection, whereas BVD is an acute infection. (wikipedia.org)