The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The circulation of blood through the CORONARY VESSELS of the HEART.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Narrowing or constriction of a coronary artery.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The hollow, muscular organ that maintains the circulation of the blood.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Spasm of the large- or medium-sized coronary arteries.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Drugs used to cause dilation of the blood vessels.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Nutrient blood vessels which supply the walls of large arteries or veins.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Elements of limited time intervals, contributing to particular results or situations.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Pathologic deposition of calcium salts in tissues.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The vessels carrying blood away from the heart.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
The blood vessels which supply and drain the RETINA.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The nonstriated involuntary muscle tissue of blood vessels.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Substances used to allow enhanced visualization of tissues.
Treatment process involving the injection of fluid into an organ or tissue.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The flow of BLOOD through or around an organ or region of the body.
The vessels carrying blood away from the capillary beds.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Contractile activity of the MYOCARDIUM.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Pressure, burning, or numbness in the chest.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Lesions formed within the walls of ARTERIES.
The physiological renewal, repair, or replacement of tissue.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The return of a sign, symptom, or disease after a remission.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The vein which drains the foot and leg.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
Formation and development of a thrombus or blood clot in the blood vessel.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Motion pictures of the passage of contrast medium through blood vessels.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The main trunk of the systemic arteries.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Obstruction of flow in biological or prosthetic vascular grafts.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
The degree to which BLOOD VESSELS are not blocked or obstructed.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Disease having a short and relatively severe course.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The minute vessels that connect the arterioles and venules.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Drugs used to cause constriction of the blood vessels.
A characteristic symptom complex.
The main artery of the thigh, a continuation of the external iliac artery.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Bleeding or escape of blood from a vessel.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Pathological conditions involving the HEART including its structural and functional abnormalities.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).

Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures. (1/8389)

We studied phasic right coronary blood flow in well trained normal dogs and dogs with pulmonic stenosis. We installed electromagnetic flow transducers and pressure tubes under anesthesia to monitor right coronary blood flow, cardiac output, central aortic blood pressure, and right ventribular pressure. In normotensive dogs, systolic flow amplitude equaled early diastolic flow levels. The ratio of systolic to diastolic flow at rest was substantially greater in the right coronary bed (36+/-1.3%) than in the left circumflex bed (13+/-3.6%). Right diastolid flow runoff, including the cove late in diastole, resembled left circumflex runoff. Blood flow to the normotensive right (37+/-1.1 ml/min 100(-1) g) and the left (35+/-1.0 ml/min(-1) g) ventricular myocardium indicated equal perfusion of both cardiac walls. Throttling of systolic flow was related directly to the right ventricular systolic pressure level in the dogs with pulmonic stenosis. Retrograde systolic flow occurred in severe right ventricular hypertension. The late diastolic runoff pattern in dogs with pulmonic stenosis appeared the same as for the normotensive dogs. We obtained systolic to diastolic flow ratios of 1/3 the value of normotensive hearts in high and severe pulmonic hypertension. Electrocardiograms and studies of pathology suggested restricted blood flow to the inner layers of the right myocardium in the dogs with severe and high right ventricular hypertension. Normotensive and hypertensive peak hyperemic flow responses were similar, except for an increased magnitude of diastolic flow, with proportionately less systolic flow in hypertensive states.  (+info)

The effect of cardiac contraction on collateral resistance in the canine heart. (2/8389)

We determined whether the coronary collateral vessels develop an increased resistance to blood flow during systole as does the cognate vascular bed. Collateral resistance was estimated by measuring retrograde flow rate from a distal branch of the left anterior descending coronary artery while the main left coronary artery was perfused at a constant pressure. Retrograde flow rate was measured before and during vagal arrest. We found that in 10 dogs the prolonged diastole experienced when the heart was stopped caused no significant change in the retrograde flow rate, which indicated that systole has little effect on the collateral resistance. However, when left ventricular end-diastolic pressure was altered by changing afterload or contractility, a direct relationship between end-diastolic pressure and collateral resistance was noted.  (+info)

Variations in 35SO4 incorporation into glycosaminoglycans along canine coronary arteries. A possible index of artery wall stress. (3/8389)

Focal areas of accentuated wall stress along the course of canine coronary arteries may be revealed by the level of 35SO4 incorporation into glycosaminoglycans (GAG). In the anterior descending artery, 35SO4 incorporation in higher in the proximal than in the distal region and may be extraordinarily high as the vessel enters a proximally located muscle bridge and at the takeoff region of multidirectional branches. In the circumflex artery, the incorporation also is higher in the proximal than in the distal region and is high at the genu where the posterior descending artery forms. There are differences in uptake of 35SO4 in vessels even when the arteries arise from the same vascular bed.this was shown by the higher incorporation in the left coronary artery than in the right coronary artery. A general anatomical agreement exists between these sites of high 35SO4 incorporation and previously described locations of interval elastic disruption ans proliferation of intimal connective tissue in the dog.  (+info)

Site of myocardial infarction. A determinant of the cardiovascular changes induced in the cat by coronary occlusion. (4/8389)

The influence of site of acute myocardial infarction on heart rate, blood pressure, cardiac output, total peripheral resistance (TPR), cardiac rhythm, and mortality was determined in 58 anesthetized cats by occlusion of either the left anterior descending (LAD), left circumflex or right coronary artery. LAD occlusion resulted in immediate decrease in cardiac output, heart rate, and blood pressure, an increase in TPR, and cardiac rhythm changes including premature ventricular beats, ventricular tachycardia, and occasionally ventricular fibrillation. The decrease in cardiac output and increase in TPR persisted in the cats surviving a ventricular arrhythmia. In contrast, right coronary occlusion resulted in a considerably smaller decrease in cardiac output. TPR did not increase, atrioventricular condition disturbances were common, and sinus bradycardia and hypotension persisted in the cats recovering from an arrhythmia. Left circumflex ligation resulted in cardiovascular changes intermediate between those produced by occlusion of the LAD or the right coronary artery. Mortality was similar in each of the three groups. We studied the coronary artery anatomy in 12 cats. In 10, the blood supply to the sinus node was from the right coronary artery and in 2, from the left circumflex coronary artery. The atrioventricular node artery arose from the right in 9 cats, and from the left circumflex in 3. The right coronary artery was dominant in 9 cats and the left in 3. In conclusion, the site of experimental coronary occlusion in cats is a major determinant of the hemodynamic and cardiac rhythm changes occurring after acute myocardial infarction. The cardiovascular responses evoked by ligation are related in part to the anatomical distribution of the occluded artery.  (+info)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (5/8389)

1. In smooth muscle of the circumflex coronary artery of guinea-pig, acetylcholine (ACh, 10(-6) M) produced an endothelium-dependent hyperpolarization consisting of two components. An initial component that occurs in the presence of ACh and a slow component that developed after ACh had been withdrawn. Each component of the hyperpolarization was accompanied by an increase in membrane conductance. 2. Indomethacin (5 x 10(-6) M) or diclofenac (10(-6) M), both inhibitors of cyclooxygenase, abolished only the slow hyperpolarization. The initial hyperpolarization was not inhibited by diclofenac nor by nitroarginine, an inhibitor of nitric oxide synthase. 3. Both components of the ACh-induced hyperpolarization were abolished in the presence of atropine (10(-6) M) or high-K solution ([K+]0 = 29.4 mM). 4. The interval between ACh-stimulation required to generate an initial hyperpolarization of reproducible amplitude was 20 min or greater, but it was reduced to less than 5 min after inhibiting cyclooxygenase activity. Conditioning stimulation of the artery with substance P (10(-7) M) also caused a long duration (about 20 min) inhibition of the ACh-response. 5. The amplitude of the hyperpolarization generated by Y-26763, a K+-channel opener, was reproducible within 10 min after withdrawal of ACh. 6. Exogenously applied prostacyclin (PGI2) hyperpolarized the membrane and reduced membrane resistance in concentrations over 2.8 x 10(-9)M. 7. At concentrations below threshold for hyperpolarization and when no alteration of membrane resistance occurred, PGI2 inhibited the initial component of the ACh-induced hyperpolarization. 8. It is concluded that endothelial prostanoids, possibly PGI2, have an inhibitory action on the release of endothelium-derived hyperpolarizing factor.  (+info)

A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig. (6/8389)

1. The purpose of this study was to compare the pharmacological properties (i.e. the AV nodal depressant, vasodilator, and inotropic effects) of two AV nodal blocking agents belonging to different drug classes; a novel A1 adenosine receptor (A1 receptor) agonist, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside (CVT-510), and the prototypical calcium channel blocker diltiazem. 2. In the atrial-paced isolated heart, CVT-510 was approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50 = 41 nM) than to increase coronary conductance (EC50 = 200 nM). At concentrations of CVT-510 (40 nM) and diltiazem (1 microM) that caused equal prolongation of S-H interval (approximately 10 ms), diltiazem, but not CVT-510, significantly reduced left ventricular developed pressure (LVP) and markedly increased coronary conductance. CVT-510 shortened atrial (EC50 = 73 nM) but not the ventricular monophasic action potentials (MAP). 3. In atrial-paced anaesthetized guinea-pigs, intravenous infusions of CVT-510 and diltiazem caused nearly equal prolongations of P-R interval. However, diltiazem, but not CVT-510, significantly reduced mean arterial blood pressure. 4. Both CVT-510 and diltiazem prolonged S-H interval, i.e., slowed AV nodal conduction. However, the A1 receptor-selective agonist CVT-510 did so without causing the negative inotropic, vasodilator, and hypotensive effects associated with diltiazem. Because CVT-510 did not affect the ventricular action potential, it is unlikely that this agonist will have a proarrythmic action in ventricular myocardium.  (+info)

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice. (7/8389)

1. Isometric tension was recorded in isolated rings of aorta, carotid, coronary and mesenteric arteries taken from endothelial nitric oxide synthase knockout mice (eNOS(-/-) mice) and the corresponding wild-type strain (eNOS(+/+) mice). The membrane potential of smooth muscle cells was measured in coronary arteries with intracellular microelectrodes. 2. In the isolated aorta, carotid and coronary arteries from the eNOS(+/+) mice, acetylcholine induced an endothelium-dependent relaxation which was inhibited by N(omega)-L-nitro-arginine. In contrast, in the mesenteric arteries, the inhibition of the cholinergic relaxation required the combination of N(omega)-L-nitro-arginine and indomethacin. 3. The isolated aorta, carotid and coronary arteries from the eNOS(-/-) mice did not relax in response to acetylcholine. However, acetylcholine produced an indomethacin-sensitive relaxation in the mesenteric artery from eNOS(-/-) mice. 4. The resting membrane potential of smooth muscle cells from isolated coronary arteries was significantly less negative in the eNOS(-/-) mice (-64.8 +/- 1.8 mV, n = 20 and -58.4 +/- 1.9 mV, n = 17, for eNOS(+/+) and eNOS(-/-) mice, respectively). In both strains, acetylcholine, bradykinin and substance P did not induce endothelium-dependent hyperpolarizations whereas cromakalim consistently produced hyperpolarizations (- 7.9 +/- 1.1 mV, n = 8 and -13.8 +/- 2.6 mV, n = 4, for eNOS(+/+) and eNOS(-/-) mice, respectively). 5. These findings demonstrate that in the blood vessels studied: (1) in the eNOS(+/+) mice, the endothelium-dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo-oxygenase but not EDHF; (2) in the eNOS(-/-) mice, NO-dependent responses and EDHF-like responses were not observed. In the mesenteric arteries acetylcholine releases a cyclo-oxygenase derivative.  (+info)

In-stent neointimal proliferation correlates with the amount of residual plaque burden outside the stent: an intravascular ultrasound study. (8/8389)

BACKGROUND: The aim of this study was to evaluate the relationship between residual plaque burden after coronary stent implantation and the development of late in-stent neointimal proliferation. METHODS AND RESULTS: Between January 1996 and May 1997, 50 patients underwent intravascular ultrasound (IVUS) interrogation at 6+/-1.2 months after coronary stent implantation in native coronary arteries. IVUS images were acquired with a motorized pullback, and cross-sectional measurements were performed within the stents at 1-mm intervals. The following measurements were obtained: (1) lumen area (LA), (2) stent area (SA), (3) area delimited by the external elastic membrane (EEMA), (4) percent neointimal area calculated as (SA-LA/SA)x100, and (5) percent residual plaque area calculated as (EEMA-SA)/EEMAx100. Volume measurements within the stented segments were calculated by applying Simpson's rule. In the pooled data analysis of 876 cross sections, linear regression showed a significant positive correlation between percent residual plaque area and percent neointimal area (r=0.50, y= 45.03+0.29x, P<0.01). There was significant incremental increase in mean percent neointimal area for stepwise increase in percent residual plaque area. Mean percent neointimal area was 16.3+/-10.3% for lesions with a percent residual plaque area of <50% and 27.7+/-11% for lesions with a percent residual plaque area of >/=50% (P<0.001). The volumetric analysis showed that the percent residual plaque volume was significantly greater in restenotic lesions compared with nonrestenotic lesions (58.7+/-4.3% versus 51.4+/-5.7%, respectively; P<0.01). CONCLUSIONS: Late in-stent neointimal proliferation has a direct correlation with the amount of residual plaque burden after coronary stent implantation, supporting the hypothesis that plaque removal before stent implantation may reduce restenosis.  (+info)

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These results show for the first time that the presence of atherosclerosis in human coronary arteries specifically augments contractions to cysteinyl leukotrienes and provides an enzymatic capacity within the vessel wall in the form of infiltrating macrophages and possibly smooth muscle cells to produce leukotrienes that could contribute to the hyperreactivity of atherosclerotic vessels. Hyperreactivity of human atherosclerotic coronary arteries to LTC4 and LTD4 was unaffected by endothelium-derived mediators. Previous reports29 have shown increased responsiveness of atherosclerotic arteries to serotonin that was unaffected by the endothelium. In those studies, hyperreactivity was reported to involve an increased responsiveness of the receptor or signal transduction system that was not apparent in the receptors present in the nondiseased arteries. Our present findings provide no evidence of cysteinyl leukotriene receptors in nonatherosclerotic epicardial coronary arteries, as suggested by the ...
Objective To visualize epicardial and intramyocardial coronary blood flow by using a noninvasive echocardiography system.. Methods In five juvenile swines, coronary flow imaging was used to visualize the different segments of epicardial coronary and intramyocardial arteries. Pulsed-Doppler spectrums were recorded and analyzed. The left anterior descending artery (LAD) and intramyocardial coronary blood flow signals were recorded at baseline and during dipyridamole administration.. Results Epicardial and intramyocardial coronary arteries could be visualized by coronary flow imaging. The systolic component of coronary flow in the right coronary artery (RCA) was greater than in the LAD. The intramyocardial blood flow was characterized by persistent retrograde blood flow velocity during systole. Vasodilation with dipyridamole produced exaggerated differences in the phasic pattern of coronary blood flow in epicardial and intramyocardial vessels.. Conclusion Color Doppler coronary flow imaging ...
The present study showed that ET-1 at small and physiological concentrations (10−11 mol/L) caused significant contraction in coronary smooth muscle cells with no detectable increases in [Ca2+]i. Although some studies have shown that picomolar concentrations of ET-1 increase [Ca2+]i in cultured human coronary smooth muscle cells,42 the present data are consistent with previous reports that these small ET-1 concentrations do not significantly increase [Ca2+]i in freshly isolated porcine coronary smooth muscle cells.32 The difference in the results could be related to differences in the cell preparation or the species studied. We should note that in the present study, [Ca2+]i was measured in an area of homogeneous fluorescence 1 μm in diameter, 1 μm from the plasma membrane, and 1 μm from the nucleus. Although small concentrations of ET-1 did not cause any detectable increases in [Ca2+]i in this representative part of the cell, small concentrations of PGF2α significantly increased [Ca2+]i in ...
B129 Mouse Coronary Artery Endothelial Cells from Creative Bioarray are isolated from coronary artery of pathogen-free laboratory B129S2/SvPasCrl mice. B129 Mouse Coronary Artery Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with PECAM-1 antibody, following the application of magnetic pre-coated with secondary antibody ...
Studies in animals with normal coronary arteries have shown that coronary flow reserve can be predicted by angiographic measurements of arterial stenosis. Studies in man, however, suggest that even quantitative analysis of coronary angiograms cannot predict the physiologic significance of individual coronary lesions. These studies, however, were carried out in patients with either widespread, diffuse coronary artery disease or by measurement techniques that tend to underestimate maximal coronary flow reserve. To determine the relationship between coronary arterial stenosis and coronary flow reserve (CFR) in patients with discrete limited coronary atherosclerosis, we studied 50 patients with a single discrete coronary stenosis in only one or two vessels. The minimum coronary arterial cross-sectional area (mCSA), percent area stenosis (%AS), and percent diameter stenosis in the left and right anterior oblique projections were determined by the Brown/Dodge method of quantitative coronary ...
OBJECTIVE--To assess whether the extent of LDL oxidation influences its cytotoxic effects, thus contributing to its atherogenic potential. DESIGN AND SETTING--The effects of native and modified LDL on cultured human coronary artery smooth muscle cells (SMC) and endothelial cells (ECs) were investigated. MAIN OUTCOME MEASURES--Four indices of cytotoxicity were studied: (i) chromium-51 release; (ii) 5-bromo-2-deoxyuridine (BrDUrd) uptake; (iii) morphological appearance; and (iv) EC migration. RESULTS--(i) Minimally modified (mm) LDL (400 micrograms/ml) causes significant 51Cr release; the cytotoxic effect was significantly greater for copper oxidised (ox) LDL (400 micrograms/ml). Native LDL had no effect. (ii) BrDUrd uptake studies showed significant inhibition of cell proliferation by 100 micrograms/ml of oxLDL and to a lesser extent by mmLDL; native LDL had no effect. (iii) Morphological appearance was not altered by native LDL. Changes in cell morphology were induced by mmLDL (400 ...
Several limitations of the present study must be considered. 1) Angiographically normal patients were included in the present study. Recently developed intravascular ultrasound has been reported [33]to demonstrate intimal thickening with a three-layered appearance in the normal coronary artery in vitro. Localized atherosclerotic lesions have been confirmed in angiographically minimally diseased coronary arteries by intravascular ultrasound in patients with focal vasospasm [34]. Diffuse concentric thickening of the coronary vessel wall might be demonstrated by intravascular ultrasound in patients with diabetes mellitus or diabetic retinopathy because in the present study, coronary diameters were significantly smaller in diabetic patients than in control patients, and minimally diseased coronary arteries ,25% were demonstrated by angiography in the left circumflex or right coronary artery in 5 patients. Such differences would be resolved by intravascular ultrasound. 2) Reduced coronary flow ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
TY - JOUR. T1 - Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. AU - Keyes, Joseph T.. AU - Lockwood, Danielle R.. AU - Simon, Bruce R.. AU - Geest, Jonathan P.Vande. PY - 2013/1. Y1 - 2013/1. N2 - Objective: Understanding coronary artery mass transport allows researchers to better comprehend how drugs or proteins move through, and deposit into, the arterial wall. Characterizing how the convective component of transport changes based on arterial location could be useful to better understand how molecules distribute in different locations in the coronary vasculature. Methods and results: We measured the mechanical properties and wall fluid flux transport properties of de-endothelialized (similar to post-stenting or angioplasty) left anterior descending (LADC) and right (RC) porcine coronary arteries along their arterial lengths. Multiphoton microscopy was used to determine microstructural differences. Proximal LADC ...
TY - JOUR. T1 - Protective effects of an indenoindole antioxidant on coronary endothelial function after long-term storage. AU - Wiklund, L.. AU - Miller, Virginia M. AU - McGregor, C. G A. AU - Sjoquist, P. O.. AU - Berggren, H.. AU - Nilsson, F.. PY - 1995. Y1 - 1995. N2 - Experiments were designed to evaluate function of the endothelium and smooth muscle of coronary arteries following storage of hearts in cardioplegia containing an inhibitor of lipid peroxidation (H 290/51, cis-7- metyl-9-methoxy-5,5a, 6,10b tetrahydroindeno [2,1-b] indole). Canine hearts were perfused with crystalloid cardioplegia (Plegisol, 15 ml/kg, 4°C) and left circumflex arteries were isolated and studied either immediately (group I, n=6), or after storage of the hearts at 4°C for 10 (group II, n=6) or 24 hr with (group III, n=6) or without (group IV, n=6) addition of H 290/51. The final concentration of H 290/51 was 1 μmol/L. Arteries were removed, cut into rings, and suspended in organ chambers for measurements of ...
Compared with the normal coronary arteries, significant alpha-adrenergic constriction of the stenotic coronary arteries can be induced by cardiac sympathetic nerve stimulation, resulting in the precipitation of myocardial ischemia with regional wall-motion abnormalities and net lactate production (26). In an experimental model, post-stenotic coronary vasoconstriction that was prevented by intravenous phentolamine or selective alpha2-blockade with rauwolscine in the absence as well as in the presence of acute beta-blockade was observed (26).. Under clinical conditions, sympathetic nerve activation may be induced by isometric as well as dynamic exercise, which may be involved in the narrowing of stenotic coronary arteries (4,5). This narrowing of the epicardial coronary segments can be prevented by administration of intracoronary nitroglycerin or the calcium-antagonist diltiazem, probably owing to the direct vasodilating properties of these two agents.. The precise mechanism responsible for ...
Definition of Circumflex coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Circumflex coronary artery? Meaning of Circumflex coronary artery as a legal term. What does Circumflex coronary artery mean in law?
TY - JOUR. T1 - Enhancement of potassium induced relaxation of isolated coronary artery smooth muscle by adenosine. AU - Foley, D. H.. AU - Mason, D. T.. AU - Amsterdam, Ezra A. PY - 1975. Y1 - 1975. N2 - Local regulation of coronary blood flow may involve an interplay of the vasoactive properties of several metabolic factors. To evaluate the effect of adenosine (Ado) on K+ induced relaxation of vascular smooth muscle, helical strips of cat coronary arteries, suspended in an organ bath of Krebs solution (37° C, 95% O2 and 5% CO2), were studied during isometric contraction stimulated by acetylcholine (ACh). From a baseline concentration of 3.0 mM, a small increment in [K+] of 2 mM induced a 16.0 ± 2.7% relaxation of tension from the initial level. However, in the presence of Ado, which induced a 20.4 ± 3.0% relaxation of 29.7 ± 4.6%. The latter was significantly greater (P , 0.005) than the response in the absence of Ado. Similarly, a 4 mM [K+] increment elicited a 14.9 ± 3.0% relaxation ...
Recent evidence suggests that higher restenosis rate is observed after coronary angioplasty of an infarct-related artery. Furthermore, angiographic restenosis seems associated with a deterioration of left ventricular function at follow-up. The aim of this study was to assess the acute results and angiographic restenosis following coronary artery stenting of infarct-related (Group 1) and non infarct-related coronary arteries (Group 2). We retrospectively analyzed the results of 381 consecutive patients treated with Palmaz-Schatz coronary stent implantation between May 1992 and January 1996. Stenting of the infarct-related artery was performed in 154 patients (Group 1), while 227 patients (Group 2) received stenting of the non infarct-related artery. Both groups had similar age, gender, clinical conditions and coronary angiographic pattern. There were no significant differences between groups, concerning type of stented coronary vessel (left anterior descending-LAD 52.4% vs non-LAD 47.6%, Group 1, ...
Olivey H.E., Svensson E.C.. The establishment of the coronary circulation is critical for the development of the embryonic heart. Over the last several years, there has been tremendous progress in elucidating the pathways that control coronary development. Interestingly, many of the pathways that regulate the development of the coronary vasculature are distinct from those governing vasculogenesis in the rest of the embryo. It is becoming increasingly clear that coronary development depends on a complex communication between the epicardium, the subepicardial mesenchyme, and the myocardium mediated in part by secreted growth factors. This communication coordinates the growth of the myocardium with the formation of the coronary vasculature. This review summarizes our present understanding of the role of these growth factors in the regulation of coronary development. Continued progress in this field holds the potential to lead to novel therapeutics for the treatment of patients with coronary artery ...
TY - JOUR. T1 - Association of remodeling with endothelial shear stress, plaque elasticity, and volume in coronary arteries. T2 - A pilot coronary computed tomography angiography study. AU - Katranas, Sotirios A.. AU - Kelekis, Anastasios L.. AU - Antoniadis, Antonios P.. AU - Chatzizisis, Yiannis S.. AU - Giannoglou, George D.. PY - 2014/5. Y1 - 2014/5. N2 - We sought to noninvasively assess the relationship between arterial remodeling, endothelial shear stress (ESS), and wall stiffness in coronary arteries. We studied 28 coronary arteries from 22 patients undergoing coronary computed tomography angiography (CCTA). The ESS was calculated in 2-mm long segments using computational fluid dynamics. Local remodeling, plaque dimensions, and local wall stiffness were assessed in each segment. The ESS was lower in the regions of excessive expansive remodeling versus compensatory expansive versus inadequate expansive versus constrictive remodeling. Areas of decreased wall stiffness more frequently ...
TY - JOUR. T1 - In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. AU - Giannoglou, George D.. AU - Chatzizisis, Yiannis S.. AU - Sianos, George. AU - Tsikaderis, Dimitrios. AU - Matakos, Antonis. AU - Koutkias, Vassilios. AU - Diamantopoulos, Panagiotis. AU - Maglaveras, Nicos. AU - Parcharidis, George E.. AU - Louridas, George E.. PY - 2006/9. Y1 - 2006/9. N2 - OBJECTIVES: The in-vivo validation of geometrically correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane coronary angiography has not been adequately investigated. The purpose of this study was to describe the reconstruction method and investigate its in-vivo feasibility and accuracy. METHODS: In 17 coronary arteries (mean length, 85.7±17.1 mm) from nine patients, an intravascular ultrasound procedure along with a biplane coronary angiography was performed. ...
A coronary arterial fistula is a connection between 1 or more of the coronary arteries and a cardiac chamber or great vessel. This is a rare defect and usually occurs in isolation (1). We report a case of coronary arterial fistula with adjacent atherosclerotic plaque treated with a covered stent in a patient with non-ST-segment elevation myocardial infarction. This 59-year-old man had a medical history of type 2 diabetes mellitus and experienced severe chest tightness. A high serum troponin I level of 3.219 ng/ml was noted, and non-ST-segment elevation myocardial infarction was diagnosed. Coronary angiography showed 3 coronary arterial fistulae at the left main coronary artery proximal and mid left anterior descending coronary artery (Figure 1A). The stenotic lesion with haziness was noted at the mid left anterior descending coronary artery, and the biggest coronary arterial fistula stood aside (Figure 1B, Online Video 1). An intravascular ultrasound study showed severe stenosis with ...
Bovine Coronary Artery Endothelial Cells: BCAEC (Cryovial); find Sigma-Aldrich-B300-05 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
A number of studies have asserted that moderate drinking has a positive benefit on cardiovascular health. Now, scientists at the University of Rochester Medical Center have discovered how alcohol consumption can help to prevent heart disease. The research, published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, studied the effects of moderate amounts of alcohol in human coronary artery smooth muscle cells and in the carotid arteries of mice [1]. In both cases, regular, limited amounts of alcohol inhibited a protein called Notch 1 and prevented the buildup of smooth muscle cells in blood vessels that leads to the narrowing of the arteries and can put you at risk for a heart attack or stroke.. ...
Coronary artery disease: A major cause of illness and death, coronary artery disease (CAD) begins when hard cholesterol substances (plaques) are deposited within a coronary artery. (The coronary arteries arise from the aorta adjacent to the heart and supply the heart muscle with blood that is rich in oxygen. They are called the coronary arteries because they encircle the heart in the manner of a crown.) The plaques in the coronary arteries can cause a tiny clot to form which can obstruct the flow of blood to the heart muscle producing symptoms and signs of CAD that may include: Chest pain (angina pectoris) from inadequate blood flow to the heart; Heart attack (acute myocardial infarction), from the sudden total blockage of a coronary artery; or Sudden death, due to a fatal disturbance of the heart rhythm. Common Misspellings: coronary artery diease, coronary artery desease ...
TY - JOUR. T1 - Role of potassium channels in coronary vasodilation. AU - Dick, Gregory M.. AU - Tune, Johnathan D.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting membrane potential (Em) and serve as targets of endogenous and therapeutic vasodilators. Em in CASMC is in the voltage range for activation of L-type Ca2+ channels; therefore, when K+ channel activity changes, Ca2+ influx and arterial tone change. This is why both Ca2+ channel blockers and K+ channel openers have such profound effects on coronary blood flow; the former directly inhibits Ca2+ influx through L-type Ca2+ channels, while the latter indirectly inhibits Ca2+influx by hyperpolarizing Em and reducing Ca2+ channel activity. K+ channels in CASMC play important roles in vasodilation to endothelial, ischemic and metabolic stimuli. The purpose of this article is to review the types of K+ channels expressed in CASMC, discuss the regulation of their activity by ...
Abstract: Systematic quantitative investigations were performed in the coronary arteries of 102 hearts of 36 mammal species with an overall more than tenthousandfold difference of their heart weight. After postmortem coronary angiography with a filling pressure of 100 mm Hg x-rays were taken, and the widest diameters of the coronary artery stems were determined. We found a nearly linear correlation between diameter of a standardized coronary artery and virtual diameter of heart, but the increase in diameter of coronary arteries exceeded somewhat that of the diameter of heart especially for heart weights surmounting 100 g. Perhaps relative enlargement of coronary arteries in the bigger hearts contributes to the prevention of large increase of blood flow velocity.. Keywords: Coronary artery diameter, Heart weight, Coronary blood flow Authors: J. W. Thüroff, W. Hort and H. Lichti. Journal: Basic Research in Cardiology. ...
2016 International Federation for Medical and Biological Engineering The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress ...
Both the right and left coronary artery ostia arise from their respective aortic sinuses. Both ostia are located more than half the distance between the sinotubular junction and aortic valve annulus (Fig. 2-1). The left main coronary artery originates with an elliptic ostium measuring approximately 3.2 ± 1.1 mm × 4.7 ± 1.2 mm.2 This coronary artery continues at an acute angle and travels parallel to the aortic sinus wall, coursing between the pulmonary artery and the left atrium in the region of the left atrial appendage. The length of the left main artery ranges from 0 mm (double-barrel ostium) to 20 mm. However, in most cases, the length of the left main coronary artery is between 6 and 15 mm, with an average diameter ranging from 3 to 6 mm.3 In two-thirds of cases, the left main coronary artery bifurcates into the left anterior descending (LAD) and circumflex arteries (Fig. 2-2); in one-third of cases, it trifurcates into the LAD artery, the circumflex artery, and a ramus intermedius ...
1. The consequences of the reduced production of nitric oxide (NO) by cells from regenerated endothelium were investigated by measuring membrane potential of smooth muscle cells (SMCs), isometric tension and cyclic nucleotides content in porcine coronary arteries with intimal thickening, four weeks following angioplasty. 2. Under basal conditions, SMCs of coronary arteries with regenerated endothelium were depolarized by 10 mV. This depolarization was associated with 82% decreased level of cGMP without alteration in cAMP. 3. Sodium nitroprusside (SNP, 1 μM) repolarized SMCs of the previously denuded coronary arteries. This repolarization was abolished by 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10 μM) and not suppressed by glibenclamide (10 μM), iberiotoxin (IbTX, 100 nM) and the combination of charybdotoxin (ChTX, 40 nM) plus apamin (100 nM). 4. Four-aminopyridine (4-AP, 1-5 mM) generated spontaneous rhythmic activities only in coronary arteries with regenerated endothelium which ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
Normal Human HUVEC Primary, 10-Donor Pool HUVEC, Aortic Endothelial, Aortic Smooth Muscle, Coronary Artery Endothelial, Coronary Artery Smooth Muscle Cells.
The current in vitro studies demonstrate an enhanced vasoconstrictor response of small coronary arteries to ET-1 and S6c in pigs with experimental hypercholesterolemia. This response is mediated mainly through the ETB receptor. These alterations in the coronary responsiveness occurred in the setting of long-term elevation of circulating ET-1. These studies support a role for both the ETA and ETB receptors in the regulation of coronary tone in the presence and absence of hypercholesterolemia.. Seo and colleagues12 previously demonstrated that the contractile response of porcine epicardial arteries to endothelins is biphasic; the first phase attained at low concentrations is primarily mediated by the endothelin ETB receptor, whereas both endothelin receptors mediate contraction in the latter, more pronounced phase attained at high concentrations. Takase and colleagues32 found similar results in noncoronary resistance vessels. The current studies extend these previous observations and demonstrate ...
I read with interest the manuscript by Ortiz-Pérez et al. (1) regarding the concordance between the 17-segment American Heart Association model (2) and coronary arterial anatomy using contrast-enhanced cardiac magnetic resonance imaging. In 93 subjects with an acute coronary syndrome, the investigators report a moderately good agreement between the actual and model-predicted coronary artery distribution and suggest that the inferior apical, lateral apical, and mid anterolateral segments are most commonly supplied by the left anterior descending coronary artery (LAD), contrary to what the model predicts.. In a previous study assessing the accuracy of a 17-segment model widely used in the nuclear cardiology literature, we projected the actual coronary artery anatomy of 135 patients undergoing coronary angiography onto the 17-segment model (3). We found that in general the model-predicted coronary anatomy was appropriate. There was only 1 segment (the apical lateral) in which the model-predicted ...
1. The electrical stimulation model of thrombus formation was tested on rabbit carotid artery and Actapted to sheep left circumflex coronary artery (LCCA). 2. LCCA blood flow, mean arterial pressure (MAP), heart rate (HR) and ECG were monitored continuously and arterial and coronary venous blood samples were taken for radioimmunoassay of thromboxane B2. 3. Stimulation of the LCCA mimicked acute myocardial infarction; reduction in LCCA blood flow preceded a fall in MAP and appearance of ECG abnormalities. 4. Thromboxane B2 levels rose by 126% 35min after stimulation. 5. These findings support the proposal by other authors that thromboxane plays an important role in the pathogenesis of acute myocardial infarction ...
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1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries.. 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. The density of specific binding sites was higher (maximum binding site density 231 ± 14 fmol/mg of protein) in the small coronary arteries than in the large epicardial coronary arteries (maximum binding site density 108 ± 5 fmol/mg of protein). β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media.. 3. In coronary artery from patients with coronary heart ...
To the best of our knowledge, this is the first reported case of percutaneous coronary intervention (PCI) on RCA ostial stenosis after re-do AVR. Coronary ostial stenosis after AVR is rare and occurs most often in the left main coronary artery, but the RCA can also be affected. An autopsy report revealed that thickened tissue in the aortic root and proximal coronary artery showed fibrosis and intimal thickening and no evidence of atherosclerosis on histological examination [1]. This phenomenon has been proposed to be due to turbulent flow around the prosthetic valve leading to obstruction of the coronary ostia. Fibrotic thickened tissue protrusion was also observed in our case, which was confirmed with homogeneous low echogenicity on IVUS.. Although the pathophysiological mechanism of coronary ostial stenosis after AVR is not well understood, various mechanisms could have mutually influenced this case according to previous studies. First, there could be micro-injury and local hyperplastic ...
The present study demonstrates the modulated expression of the adhesion molecule E-selectin via angiotensin II in human coronary endothelial cells. Evidence for this pathway was obtained from measurements of increased antigen expression at the protein level as well as from increased mRNA content. Functionally, the angiotensin II-induced expression of E-selectin leads to an increase of HL-60 cell adhesion, as demonstrated under near-physiological flow conditions. The effects of angiotensin II on E-selectin expression appear to be mediated by an AT1 (angiotensin II) receptor, since the AT1-receptor antagonist DUP 753 but not the AT2-receptor antagonist PD 123177 suppressed E-selectin-dependent adhesion. These observations indicate a link between the renin-angiotensin system and the expression of E-selectin, which is thought to play a crucial role in the processes of inflammation and atherosclerosis.1 26 27 Adhesion molecule expression on endothelial cells after stimulation with angiotensin II was ...
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 Oct; 61(4):429-439. . View in PubMed. The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. . View in PubMed. Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration Cell Stem Cell. 2017 12 07; 21(6):712-714. . View in PubMed. Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells J Biosci. 2016 Dec; 41(4):659-666. . View in PubMed. The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. . View in PubMed. Alterations of voltage-dependent K(+) channels in ...
The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining techniques in transverse sections taken from the upper, middle, and lower segments of the anterior part of the interventricular region and the adjacent parts of the right and left ventricles containing epicardial nerves and the endocardial peripheral parts of the Purkinje fibers. In total, 317 epicardial nerves were detected. The vasa nervorum were present in 75.7% of these nerves. The vasa nervorum resembled arterioles and postcapillary and collecting venules. One hundred and forty nine epicardial nerves were perivascular, located in the adventitia of the anterior interventricular artery and vein. The remaining 168 nerves ran freely through the epicardial interstitium. The presence of ...
Background. Experimental studies on the effects of alpha2-adrenoceptors on regional coronary blood flow in normal and ischemic myocardium are highly controversial. A beneficial effect on regional ischemic myocardium has been demonstrated in different animal preparations with either alpha2-adrenoceptor blockade or stimulation. Animal studies also demonstrated that postsynaptic alpha2-adrenoceptors mediate vasoconstriction in coronary and femoral vascular beds. The aims of the study were 1) to investigate the effects of regional alpha2-adrenoceptor stimulation on regional coronary blood flow in subjects with angiographically normal coronary arteries, 2) to assess the effect of alpha2-adrenoceptor blockade on coronary circulation in control subjects, and 3) to examine the influence of atherosclerosis on coronary blood flow response to alpha2-adrenoceptor blockade. Methods and Results. The effect of regional administration of BHT 933 (a selective alpha2-adrenoceptor agonist) was studied in eight ...
Previously we reported that the P2Y2 receptor (P2Y2R) is one of the predominant purinergic receptors expressed in human coronary artery endothelial cells (HCAEC), and that P2Y2R activation by ATP or UTP induces dramatic up-regulation of tissue factor (TF), key initiator of the coagulation cascade. However, the molecular mechanism of this P2Y2R-TF axis remains unclear. Here we report a role of a newly identified AP-1 consensus sequence along with its new binding components in P2Y2R regulation of TF transcription. We identified with bioinformatics tools that a novel AP-1 site at -1363 bp of human TF promoter region is highly conserved across multiple species. P2Y2R activation increased TF promoter activity and mRNA expression in HCAEC. Truncation, deletion, and mutation of this new distal AP-1 site all significantly supressed TF promoter activity in response to P2Y2R activation. EMSA and ChIP assays further confirmed that upon P2Y2R activation, c-Jun, ATF-2 and Fra-1, but not the typical c-Fos, ...
The effect of a new coronary vasodilator (Persantin), which produces a marked increase in coronary blood flow (up to 159 per cent in normal animals) without increasing cardiac contractility or cardiac work, has been studied in the experimental animal. This is associated with a marked decrease in coronary resistance. There is an increase in the coronary venous oxygen content and a decrease in the coronary A-V oxygen difference; the cardiac output is only slightly affected. Increase in the coronary blood flow has also been observed in dogs in which coronary in sufficiency has been produced by coronary ligation and by narrowing of the lumen of the coronary artery by the application of casein rings. This was accompanied by no significant increase in cardiac work.. ...
In this study, we investigate plaques located at the left coronary bifurcation. We focus on the effect that the resulting changes in wall shear stress (WSS) and wall pressure stress gradient (WPSG) have on atherosclerotic progress in coronary artery disease. Coronary plaques were simulated and placed at the left main stem and the left anterior descending to produce ,50% narrowing of the coronary lumen. Computational fluid dynamics analysis was carried out, simulating realistic physiological conditions that show the in vivo cardiac haemodynamic. WSS and WPSG in the left coronary artery were calculated and compared in the left coronary models, with and without the presence of plaques during cardiac cycles. Our results showed that WSS decreased while WPSG was increased in coronary side branches due to the presence of plaques. There is a direct correlation between coronary plaques and subsequent WSS and WPSG variations based on the bifurcation plaques simulated in the realistic coronary ...
To study the role of 320-detector coronary computed tomography angiography (CTA) in assessing native coronary arteries in patients treated with coronary stents. 123 patients with coronary stenting received both CTA and conventional coronary angiography (CCA) within 1 day. The clinical parameters, coronary calcium scoring, CTA and CCA were analyzed to determine the prevalence of significant stenosis of native coronary arteries (SSNCA), the predictive value of CTA and the factors correlating with SSNCA and newly developed SSNCA after stenting (NDSSNCAS), with CCA as the standard of reference, using both vessel-based analysis (VBA) and patient-based analysis (PBA). Both the source and the reconstructed images were analyzed by CTA. All native coronary arteries were interpretable independent of cardiac motion. CTA showed a sensitivity/specificity of 93.5 %/97.3 % and 92.5 %/92.5 % in diagnosing SSNCA in VBA and PBA, respectively. The significant factors related to SSNCA were higher calcium scores (P ...
The main goal of AIM III is to assess and quantify the effect of long-term administration of darapladib 160 mg once a day, a selective, reversible, orally active inhibitor of plasma and vascular Lp-PLA2, on coronary endothelial function, progression of coronary atherosclerosis as determined by intravascular ultrasound (IVUS), and atherosclerosis in patients with early atherosclerosis. Patients with evidence of coronary endothelial dysfunction, as determined by intracoronary administration of acetylcholine during angiography and IVUS, will be followed for 6 months during once daily dosing of darapladib. Coronary endothelial function is determined by the changes in coronary artery diameter and coronary blood flow response to the intracoronary administration of acetylcholine and adenosine. The patients will be followed in clinic 6 months. They will have follow-up angiography, assessment of endothelial function, and IVUS during the six month visit ...
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Although atherosclerosis is a systemic disease, plaque progression and complications occur in a focal, patchy pattern. It remains challenging to predict which segments of a given coronary artery will show accelerated progression of atherosclerosis.. Coronary endothelial dysfunction, characterized by a segmental vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine, is considered the earliest stage of atherosclerosis in patients with angiographically nonobstructive coronary arteries. Therefore, sites with endothelial dysfunction may signal future progression of segmental coronary atherosclerosis (1). Using serial intravascular ultrasound (IVUS) imaging, we tested the hypothesis that coronary segments with endothelial dysfunction are associated with plaque progression in patients with nonobstructive coronary artery disease.. In this prospective study, 22 patients underwent coronary angiography with coronary endothelial function assessment and IVUS for clinical purposes ...
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Definitive diagnosis of coronary artery spasm often begins with a coronary angiogram that is performed with the expectation of finding atherosclerotic narrowing of a heart artery. Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. Two patients had coronary artery disease, and three had angiographically normal coronary arteries.. Acting fast at the first sign of heart attack symptoms can save your life and limit damage to your heart. Whether you have had a heart attack or not, if you feel depressed, tell your doctor. You can even have a silent heart attack, one with no symptoms. The symptoms of a heart attack can vary from person to person. To prevent a heart attack, you will most likely need to make lifestyle changes. The patient may need to be hospitalized to prevent a heart attack.. Without normal blood flow from the coronary arteries the heart becomes lack of oxygen and vital nutrients ...
5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how 5-HT causes relaxation of coronary arteries has been less investigated. In isolated rat hearts, 5-HT-induced coronary flow increases are partially resistant to the nitric oxide synthase inhibitor Nω-Nitro-L-arginine methyl ester (L-NAME) and are blocked by 5-HT7 receptor antagonists. In the present study, we investigated the role of 5-HT7 receptor in 5-HT-induced coronary flow increases in isolated rat hearts in the absence of L-NAME, and we also evaluated the involvement of endothelium-derived hyperpolarizing factor (EDHF) in 5-HT-induced coronary flow increases in L-NAME-treated hearts with the inhibitors of arachidonic acid metabolism and the blockers of Ca2+-activated K+ channels. In isolated rat hearts, 5-HT and the 5-HT7 receptor agonist 5-carboxamidotryptamine induced coronary flow
Objective: Streptococcus mutans is the leading cause of dental caries worldwide and a causative agent of infectious endocarditis. Collagen binding protein, Cnm, is expressed by about 10% of S.mutans clinical strains. Here, we investigate the role of Cnm in adherence, invasion, and persistence of human coronary artery smooth muscle cells (CASMC) in vitro. Methods: Adherence and Antibiotic Protection Assay: Human cells were infected with wildtype strains of S.mutans and their corresponding cnm mutants: OMZ175, OM50E, LM7, NCTC11060. S.mutans UA159, a natural cnm negative strain, was used as a negative control. For adherence, human cells were infected at MOI 100 and incubated for 30 min at 4oC. For invasion, human cells were infected at MOI 100 for 2 hours, washed, antibiotic treated for 3 hours to kill extracellular bacteria. Cells were lysed, serially diluted and plated on BHI, and CFUs determined. Quantitative PCR: Antibiotic protection assay with strain OMZ175 was completed, except cells were ...
TY - JOUR. T1 - Angina Due to Coronary Microvascular Disease in Hypertensive Patients without Left Ventricular Hypertrophy. AU - Brush, J. E.. AU - Cannon, R. O.. AU - Schenke, W. H.. AU - Bonow, R. O.. AU - Leon, M. B.. AU - Maron, B. J.. AU - Epstein, S. E.. PY - 1988/11/17. Y1 - 1988/11/17. N2 - When angina occurs in patients with hypertension, it is usually attributed to coronary artery disease or left ventricular hypertrophy. To determine the contribution of coronary microvascular abnormalities to angina in patients with hypertension, we evaluated hypertensive patients without coronary artery disease or left ventricular hypertrophy by measuring the coronary responses to rapid atrial pacing before and after administration of ergonovine. We compared 12 hypertensive patients who had pacing-induced angina with 13 normotensive subjects without such angina. The two groups had similar coronary flow (in the great cardiac vein) at rest; however, pacing increased coronary flow less in hypertensive ...
The bioavailability of nitric oxide (NO) in the human coronary circulation at rest and after acetylcholine (ACH)-induced vasodilation was investigated in 32 patients with angiographically normal coronary arteries. The effects of intracoronary L-NG monomethyl arginine (L-NMMA) were investigated at rest and after ACH, sodium nitroprusside, and adenosine. L-NMMA (64 mumol/min) increased resting coronary vascular resistance by 22% (P , 0.001), reduced distal epicardial coronary artery diameter by 12.6% (P , 0.001), and inhibited ACH-induced coronary epicardial and microvascular vasodilation. These effects were reversed with intracoronary L-arginine. L-NMMA did not inhibit dilation in response to sodium nitroprusside and adenosine. 23 patients were exposed to one or more coronary risk factors. The vasoconstrictor effect of L-NMMA on the epicardial and microvessels was greater in patients free of risk factors: Coronary vascular resistance was 36% higher in patients without risks, compared to 17% ...
Time resolved coronary vessel wall imaging using TRAPD successfully restored the negative polarity of lumen signal and enhanced lumen-wall contrast in the cine images in flow-phantom (Figure 1), and in both normal and subjects with coronary risk factors (Figure 2). The acquisition and utilization of the additional frames increased the cumulative success rate of acquiring at least one adequate-quality image from 76% in single-image acquisitions to over 90% when five frames were acquired. Utilizing multiple consecutive frames in calculations achieved more separation between the normals and patients mean wall thickness values, and with more precision demonstrated by a narrower standard deviation. The difference in vessel wall thickness between the two subject groups was statistically significant (p,0.05) when using TRAPD (1.07 mm vs. 1.46 mm; 36% increase) compared to single-frame DIR imaging (1.24 mm vs. 1.55 mm; 25% increase). ...
Problem statement: Stent thrombosis, which may occur even one year after stent implantation, is a drawback of Drug-Eluting Stents (DES). Among the variety of causes of stent thrombosis after DES implantation, coronary endothelial dysfunction manifested or exaggerated by DES implantation should not be overlooked. This review article summarizes previous reports on coronary endothelial dysfunction after DES implantation and/or coronary spasm and discusses the mechanism, clinical implications and prognosis. Although novel stents that do not impair endothelial function will most likely be developed in the near future, millions of patients have already undergone implantation of a first or second generation DES. Conclusion/Recommendations: Some studies have reported that a drug improves the impairment of endothelial function. On the other hand, no direct relationships between spasm and stent thrombosis after DES implantation have been reported. A larger study is warranted to clarify the clinical significance
Coronary artery disease is currently the leading cause of death and disability in the United States. Doctors have identified risk factors for treating and delaying cardiac disease, and testing has increasingly become more sophisticated. One of these tests that doctors order and assess carefully is the coronary artery calcium score, or CAC. While it is an independent predictor of coronary artery disease, the score is combined with information from conventional cardiac risk factors to provide very useful information.. In coronary artery disease, a fatty material called plaque narrows the coronary artery diameters and limits blood flow crossing the heart. This most common cause of heart disease in both women and men leads to chest pain, heart attack, arrhythmia, and in advanced cases, heart failure. Coronary artery calcium screening is done with an electron beam CT scan which looks for coronary calcium on the cardiac vessel walls. Calcification within the arteries can be one of the earliest signs ...
Coronary angiography (an-jee-OG-ra-fee) is a test that uses dye and special x rays to show the inside of your coronary arteries. The coronary arteries supply blood and oxygen to your heart. A material called plaque can build up on the inside walls of the coronary arteries and cause them to narrow. When this happens, its called coronary artery disease (CAD). This can prevent enough blood from flowing to your heart and can lead to angina (an-JI-nuh or AN-juh-nuh) (chest discomfort or pain) and heart attack. Coronary angiography shows if you have CAD. Most of the time, the coronary arteries cant be seen on an x ray. During coronary angiography, a special dye is injected into the bloodstream to make the coronary arteries show up on an x ray. To deliver the dye to your coronary arteries, a procedure called cardiac catheterization (KATH-e-ter-i-ZA-shun) is used. A long, thin, flexible tube called a catheter is put into a blood vessel in your arm, groin (upper thigh), or neck. The tube is then ...
Chest pain;Pulmonary vein thrombosis;Coronary artery stenosis;Syndrome X;64-MDCT Chest pain is a typical symptom of ischemic coronary artery diseases. Patients with ischemic coronary artery diseases typically have coronary artery stenosis, although approximately 10-20% of patients with angina pectoris have normal coronary artery, and most of these patients are syndrome X that showed slow coronary flow [1] ; [2]. In addition, patients with chest pain but with an intact coronary artery stenosis were reported [3] ; [4]. Although occlusion of the small coronary arteries has been suggested as a cause of chest pain and atherosclerosis [5], the origin of the microclots that cause coronary artery occlusions remains unknown. Pulmonary vein thrombosis was hypothesized to be a rare complication associated with lung cancers and thoracic surgeries; however, since 2012, I have published several cases of pulmonary vein thrombosis in elderly patients with chest pain using a 64-slice multidetector CT (64-MDCT) ...
TY - JOUR. T1 - Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus. T2 - Implications for reactive oxygen species. AU - Bagi, Zsolt. AU - Feher, Attila. AU - Beleznai, Timea. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Type 2 diabetes mellitus is associated with clustering of cardiovascular risk factors that may greatly increase individuals risk of developing coronary artery disease. Type 2 diabetes is believed to impair coronary function. However, its impact on the vasomotor function of coronary resistance vessels in humans is still debated. Reduced, preserved or even augmented dilations of coronary arterioles have been reported in subjects with type 2 diabetes. Interestingly, recent studies have suggested that reactive oxygen species (ROS), particularly hydrogen peroxide, may compensate for the loss of the vasodilatory function of coronary microvessels during disease development. Recent interventional clinical trials have yielded largely negative results, and there has ...
Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a small proportion of the dramatically increased risk of atherosclerotic coronary artery disease (CAD) in systemic lupus erythematosus (SLE). However, in these studies, exposure to risk factors was measured only at baseline. In this study, our objective was to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP), and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE. Patients in the Toronto lupus cohort had TC and BP measured at each clinic visit and were followed up prospectively for the occurrence of CAD. For each patient, arithmetic mean, time-adjusted mean (AM) and area-under-the-curve (AUC) were calculated for serial TC, SBP, and DBP measurements. Proportional hazards regression models were used to compare these summary measures with recent and first adds 2014 Research Report on Global and China Coronary Stent Industry report to its research database.. This is a professional and depth research report on Global and China Coronary Stent Industry. Firstly the report describes the background knowledge of Coronary Stent, including Coronary Stent Concepts Classification production process technical parameters; then statistics Global and China 18 Manufacturers Coronary Stent product 2009-2017 Capacity production cost price production value Gross margins and other relevant data, statistics these enterprises Coronary Stent products, customers, raw materials, company background information, then summary statistics and analysis the relevant data of these enterprises. and get Global and China Coronary Stent 2009-2017 production market share, different regions and Type Coronary Stent production market share, Global and China Coronary Stent demand supply and shortage, Global and China Coronary Stent 2009-2017 production price cost ...
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Coronary Artery Calcium Imaging and Scoring (CAC Score). Coronary artery calcium (CAC) scoring is an easy, convenient, painless, non-invasive imaging technique to detect and evaluate the amount of calcium deposition in the coronary arteries (i.e. blood vessels supplying the heart muscle). It gives an idea of whether early cholesterol plaque have begun to infiltrate the coronary arteries despite the lack of any symptoms and will likely to progress in the years to come.. The degree of calcium deposition corresponds to the severity of the atheromatous plaque and the likelihood of a heart attack (see table 1). The higher the calcium score, the greater the risk and is used by cardiologists as one of the tools to assess and correlate with the risk of adverse cardiovascular events. Although not directly correlated - the higher the calcium score (termed the calcium burden), the greater the chance of more severe narrowing of the coronary arteries. Conversely a low calcium score although suggests a low ...
2] Coronary sinus ASDs are believed to arise from developmental failure of formation of the wall between the coronary sinus and the left atrium.. The coronary sinus is a systemic venous structure embryologically derived primarily from the left common cardinal vein that is continuous with the left anterior cardinal vein. Coronary sinus ASDs involve the inferior and anterior interatrial septa at the usual location of the orifice of the coronary sinus. The orifice of the coronary sinus becomes continuous with the left atrial chamber when a defect occurs in the wall separating the left atrium from the coronary sinus. This arrangement allows shunting between the atria.. From the right atrial aspect of the interatrial septum, the defect may consist of the coronary sinus orifice alone or with additional deficiency of atrial septal tissue around the coronary sinus orifice. On the left atrial side, the defect consists of partial or complete unroofing of the coronary sinus, if the entire superior aspect ...
Acute coronary obstruction occurred in two patients during coronary angiography. In one case the obstruction was in the left main coronary artery; in the other it was close to the origin of the left anterior descending artery. In both cases acute cardiac ischaemia ensued, with electromechanical dissociation and collapse, which was not reversible by resuscitation. Rapid disobliteration of the occluded coronary artery was done with a guide-wire pushed through the obstruction via the coronary catheter. The recanalisation was completed by an intracoronary perfusion of streptokinase in one case. In both cases recovery was rapid and spectacular. The occurrence of acute ischaemia during coronary angiography should suggest accidental coronary occlusion. If a thromboembolic origin is suspected, transluminal disobliteration should be attempted. It is simple and can reverse a dangerous condition ...
A coronary stent is a tubular structured device made of a thin mesh of wire, which may also be coated with a polymer containing a drug, or made of biodegradable materials. Coronary stents are utilized during percutaneous coronary interventions (PCIs) for the treatment of patients suffering from various coronary artery diseases (CADs) such as acute myocardial infarction, angina pectoris and others. At present, several researches are being conducted in the field of coronary stenting, in order to minimize side effects such as restenosis and thrombosis. Certain new and advanced coronary stents such as bio-absorbable stents have been commercialized in the global market, which demonstrate very less or no common side effects of coronary stenting.. Request a Sample Copy of the Report @ The market for coronary stents can be broadly classified into three major segments, namely, bare metal stents (BMS), drug eluting stents (DES) and bio-absorbable stents. In 2011, the drug ...
TY - GEN. T1 - Computational fluid dynamics analysis of the effect of simulated plaques in the left coronary artery. T2 - A preliminary study. AU - Chaichana, Thanapong. AU - Jewkes, James. AU - Sun, Zhonghua. PY - 2011. Y1 - 2011. N2 - Background: Atherosclerosis is the most common cause of coronary artery disease which is formed by plaque presence inside the artery wall leading to blockage of the blood supply to the heart muscle. The mechanism of atherosclerotic development is dependent on the blood flow variations in the artery wall during cardiac cycles. Characterization of plaque components and investigation of the plaques with subsequent coronary artery stenosis and myocardial dysfunction has been extensively studied in the literature. However, little is known about the effect of plaques on hemodynamic changes to the coronary artery, to the best of our knowledge. Investigation of the position of plaques in the coronary artery and its corresponding regional hemodynamic effects will provide ...
Coronary intravascular ultrasound (IVUS): Coronary intravascular ultrasound (IVUS) uses small catheters with ultrasound transducers at the tip to image the coronary arteries with ultrasound from within the lumen. The special catheters can be introduced through a guide catheter into the main coronary arteries. They are then connected to the the ultrasound equipment kept in the console. Imaging is done as the catheter is pulled back and recorded. It is very useful to detect abnormalities in the vessel wall which can be missed by conventional coronary angiography. When a coronary stent has been implanted, IVUS imaging is very helpful to check whether all parts of the stent has been well apposed to the vessel wall.. ...
Abstract: Objective To assess the role of computed tomography angiography (CTA) using dual-source computed tomography in the preoperative evaluation of old patients scheduled for noncardiac surgery. Methods A retrospective review of the clinical data of patients who underwent CTA in our hospital between May 2011 and May 2013 was performed,and totally 111 old patients with risk factors of coronary artery diseases scheduled for noncardiac surgery were found to coronary CTA for preoperative evaluation. Prospectively electrocardiograph-triggered sequence scan protocol with dual-source computed tomography was performed. The imaging quality,coronary artery stenosis,the treatment before operation,and perioperative complications were assessed. Results For 1 779 coronary artery segments in 111 patients,the number of evaluable segments was 1 676 (97.4%). The mean effective dose of CTA was (2.7±0.9) mSv. Among them,71 patients with coronary artery stenosis ...
TY - JOUR. T1 - Association between the paraoxonase-1 192Q,R allelic variant and coronary endothelial dysfunction in patients with early coronary artery disease. AU - Lavi, Shahar. AU - McConnell, Joseph P.. AU - Lavi, Ronit. AU - Barsness, Gregory W.. AU - Rihal, Charanjit S.. AU - Novak, Gregory D.. AU - Lerman, Lilach O. AU - Lerman, Amir. PY - 2008. Y1 - 2008. N2 - OBJECTIVE: To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothelial dysfunction, an early stage of atherosclerosis. PATIENTS AND METHODS: We assessed 192Q,R and 55L,M allelic variants of the paraoxonase gene and coronary endothelial function in response to intracoronary acetylcholine in 99 patients (52 with homozygous QQ, 47 with homozygous RR or heterozygous QR). The study was conducted from September 1, 2002, through November 30, 2004. RESULTS: Of 52 homozygous QQ patients, 39 (75%) had endothelial dysfunction vs 20 (43%) of the 47 RR/QR patients (P=.001), and this association ...
Coronary vessels. Main article: Coronary circulation. The heart itself is supplied with oxygen and nutrients through a small " ... The coronary circulation begins near the origin of the aorta by two coronary arteries: the right coronary artery and the left ... The cardiovascular (from Latin words meaning "heart" and "vessel") system comprises the blood, heart, and blood vessels.[3] The ... After nourishing the heart muscle, blood returns through the coronary veins into the coronary sinus and from this one into the ...
Estrogen affects certain blood vessels. Improvement in arterial blood flow has been demonstrated in coronary arteries.[37] ... "17 beta-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart ...
Left main or multi vessel coronary artery disease. Need for open heart surgery within 30 days. Left ventricular ejection ... The internal, common and external carotid arteries are carefully identified, controlled with vessel loops, and clamped. The ...
In atherosclerosis, a severe disease in modern society, coronary blood vessels occlude. These vessels have to be freed and held ... Usually autologous vessels from the patient or synthetic polymer grafts are used for this purpose. Both options have ... Firstly there are only few autologous vessels available in a human body that might be of low quality, considering the health ... Unfortunately after certain time these vessels close again and have to be bypassed to allow for upkeep of circulation. ...
Usually in children(age,4), it affects large, medium, and small vessels, prominently the coronary arteries. Associated with a ... Medium vessel vasculitis[edit]. These conditions are sometimes considered together with the small vessel vasculitides.[11] ... Small vessel vasculitis[edit]. There are several vasculitides that affect small vessels.[12] ... Seo P, Stone JH (December 2007). "Small-vessel and medium-vessel vasculitis". Arthritis Rheum. 57 (8): 1552-9. doi:10.1002/art. ...
Notably, cardiac muscle perfusion through the heart's coronary vessels doesn't happen during ventricular systole; rather, it ... coordinated depolarisation and excitation-contraction coupling from the apex of the heart up to the roots of the great vessels ...
2008). "Drug-eluting or bare-metal stents forlarge coronary vessel stenting? The BASKET-PROVE (PROspective Validation ...
Peripheral angioplasty refers to the use of a balloon to open a blood vessel outside the coronary arteries. It is most commonly ... A coronary angiogram (an X-ray with radio-opaque contrast in the coronary arteries) that shows the left coronary circulation. ... A coronary angioplasty is a therapeutic procedure to treat the stenotic (narrowed) coronary arteries of the heart found in ... A percutaneous coronary intervention is first performed. A PCI used with stable coronary artery disease reduces chest pain but ...
Shepherd, JT; Wood, EH (May 1959). "The role of vessel tone in pulmonary hypertension". Circulation. 19 (5): 641-645. doi: ... particularly in the coronary arteries, in man". Am J Cardiol. 32 (2): 144-150. doi:10.1016/s0002-9149(73)80112-2. PMID 4578631 ... Smith, HC; Sturm, RE; Wood, EH (August 1973). "Videodensitometric system for measurement of vessel blood flow, ...
Pratt, FH (1898). "The nutrition of the heart through the vessels of Thebesius and the coronary veins" (PDF). American Journal ... and into the coronary sinus. The coronary sinus empties into the right atrium. The thebesian venous network is considered an ... "vessels of Wearn". In his 1928 publication, Wearn himself referred to the arterio-cameral connections (vessels of Wearn) as ... As a consequence of the input of these vessels, blood in the left heart is less oxygenated than the blood found at the ...
CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance ...
... he was hospitalized with a coronary lesion and a damaged blood vessel.[14] In October he was again in hospital with a lung ...
Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for ...
This drug is administered intravenously and can be used to dissolve blood clots in coronary vessels. However, streptokinase is ... Mural thrombi are thrombi that adhere to the wall of a blood vessel. They occur in large vessels such as the heart and aorta, ... A thrombus in a large blood vessel will decrease blood flow through that vessel (termed a mural thrombus). In a small blood ... This may be aided by drugs (for example after occlusion of a coronary artery). The best response to fibrinolytic drugs is ...
MRI coronary vessel wall imaging, although currently limited to research studies, has demonstrated the ability to detect vessel ... There was incremental significant increase in CIMT with the number coronary vessel involved. In accordance with the literature ... Coronary Artery Atherosclerosis at eMedicine Waller BF, Orr CM, Slack JD, Pinkerton CA, Van Tassel J, Peters T (June 1992). " ... Angiogram ApoA-1 Milano Atherosclerosis Atherothrombosis Coronary circulation Coronary catheterization EBT Hemorheologic- ...
... caused by the thickening of the coronary arteries and blood vessels.[296] In 1993, he was diagnosed with B cell lymphoma in the ...
The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... "The U wave is the momentum carried by the blood in the coronary arteries and blood vessels". The resistivity of stationary ... which gradually increases high up in the coronary arteries and blood vessels. ... The interior of a blood vessel includes a near-wall layer of plasma (referred to as lubricant), the size of which strictly ...
... is thought to heal coronary and blood vessels diseases, increased blood pressure and rheumatic disorders. It also ...
It is used on both small vessels such as coronary artery bypasses and large vessels including the aorta. It is used in ...
Stegmann TJ (2005). New vessels for the heart : angiogenesis as new treatment for coronary heart (1st ed.). Henderson, NV: ... Unlike normal blood vessels, tumor blood vessels are dilated with an irregular shape. In 2007, it was discovered that cancerous ... In this type of vessel formation, the capillary wall extends into the lumen to split a single vessel in two. There are four ... Evidence now suggests the blood vessel in a given solid tumor may, in fact, be mosaic vessels, composed of endothelial cells ...
... the pressure gradient between the segment of the coronary vessel distal to the occlusion and the incipient collateral vessel ... also vessel collateralization and blood vessel collateralization, is the growth of a blood vessel or several blood vessels that ... Coronary collateralization exists latently in the normal heart. Microscopic collateral vessels of the heart undergo a process ... Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion. Coron Artery Dis. 2002 May ...
Integrating this therapy with percutaneous coronary angioplasty (hybrid procedure) offers multi-vessel revascularization ... Thus hybrid coronary revascularization and MIDCAB (minimally invasive direct coronary artery bypass surgery) have been ... For people who undergo coronary artery bypass grafting, coronary imaging (completion angiography) for the routine evaluation of ... Surgical bypass grafting and percutaneous coronary artery revascularization are traditionally considered isolated options. A ...
... forcing the solution into the coronary vessels, which normally supply the heart tissue with blood. This feeds nutrients and ... In the Langendorff preparation, the heart is removed from the animal's body, severing the blood vessels; it is then perfused in ... The Langendorff heart preparation-Reappraisal of its role as a research and teaching model for coronary vasoactive drugs, K.J. ...
Peripheral angioplasty refers to the use of a balloon to open a blood vessel outside the coronary arteries. It is commonly done ... To treat a narrowing in a blood vessel, a wire is passed through the stenosis in the vessel and a balloon on a catheter is ... If no access vessel of sufficient size and quality is available, angioplasty is contraindicated. A small vessel diameter, the ... A percutaneous coronary intervention is first performed. A PCI used with stable coronary artery disease reduces chest pain, but ...
He tells Foreman that the cardiac arrest was a coronary event, meaning Jack's coronary vessels were obstructed, which can't be ... It is, meaning it is most likely affecting the small blood vessels which explains why they did not see any inflammation on the ...
In rat coronary vessels, PKA mediates inhibition of calcium-independent phospholipase A and calcium influx which results in ... Ucn2 produced a dose dependent relaxation of coronary. This correlation was a result of the cAMP/ PKA pathway and independent ... It is highly selective for CRF2 which is predominantly found in the myocardium, blood vessels and peripheral tissues. This ... increased coronary flow, significantly altered intracellular calcium handling and increased SR calcium. These relaxation ...
Coronary circulation is the circulation of blood in the blood vessels of the heart muscle (myocardium). The vessels that ... "How Is Coronary Heart Disease Diagnosed?". 29 September 2014. Retrieved 25 February 2015. "How Can Coronary Heart Disease Be ... As the left and right coronary arteries run on the surface of the heart, they can be called epicardial coronary arteries. These ... Procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) may be used in severe ...
Coronary small vessel disease is a type of coronary heart disease (CHD) that affects the arterioles and capillaries of the ... Coronary small vessel disease is also known as cardiac syndrome X, microvascular dysfunction, non-obstructive coronary disease ... disease of blood vessels) affecting small blood vessels in the body. It can be contrasted to macroangiopathy, or large vessel ... Cerebral small vessel disease refers to a group of diseases that affect the small arteries, arterioles, venules, and ...
In 1957, Lown was concerned with how to visualize an atherosclerotic aortic plaque, which occurs in the big coronary vessels ... "The Coronary Artery Entrapment". 31 July 2012.. *^ Dersiewicz, Bill (Winter 1990). "Bernard Lown Speaks From the Heart". ... Among these were the coronary care unit. His work made possible and safe much of modern cardiac surgery, as well as a host of ... Lidocaine was also used in coronary units to prevent the need for resuscitation. Previously, lidocaine was used almost ...
Percutaneous coronary intervention (PCI) - Procedures to treat stenotic coronary arteries by accessing through a blood vessel. ... Coronary artery disease (CAD)- Coronary artery disease is a general term for any reduction in coronary circulation. One such ... Diseases of blood vessels - diseases of the blood vessels can be multidisciplinary in nature. For example, medical treatment of ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ...
blood vessel remodeling. •skeletal muscle tissue development. •respiratory gaseous exchange. •blood circulation. •cell ... 2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ...
... is used to view the vessels under X-ray. Angiography is used to find aneurysms, leaks, blockages (thromboses), new vessel ... Since liquid blood and the vessels are not very dense, a contrast with high density (like the large iodine atoms) ...
Others suggest that music serves as a sort of mediator for social interactions, providing a vessel through which to interact ... and blood pressure in those with coronary heart disease (CHD).[37] ... "Music for stress and anxiety reduction in coronary heart disease patients". The Cochrane Database of Systematic Reviews (12): ...
Cardiovascular disease (vessels) (I70-I99, 440-456). Arteries, arterioles. and capillaries. Inflammation. *Arteritis *Aortitis ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
t-PA is released into the blood very slowly by the damaged endothelium of the blood vessels, such that, after several days ( ... They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ...
... and coronary arteries.[8] to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 ... Blood Vessels. 26 (2): 119-27. PMID 2474340.. ...
Campbell has been developing a technique to grown the artificial blood vessel in the body cavity of the person it will be ... This process is undergoing pre-clinical trials in humans and may be used to treat patients suffering coronary heart disease, ... Campbell has won worldwide acclaim for her ground-breaking research into the development of blood vessels naturally within a ... This 'Grow Your Own Arteries' technique is helping patients survive coronary heart disease, renal failure and other life- ...
The tissue hardens and thickens which is known as nephrosclerosis.[2] The narrowing of the blood vessels means less blood is ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... High blood pressure in the long term can damage the endothelium, commonly known as the blood vessel lining. This leads to a ... Glomerulosclerosis is often present, either focally or globally, which is characterized by hardening of the vessel walls. Also ...
They are often due to damage of blood vessels and connective tissue cells. Many late effects are reduced by fractionating ... coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, vascular cell damage and ... for example when the tumor is wrapped around a vulnerable structure such as the spinal cord or a major organ or blood vessel.[ ... heat therapy which dilates blood vessels to the tumor site), blood substitutes that carry increased oxygen, hypoxic cell ...
Coronary artery angioscopy, which first was used to reveal the presence of a blood clot in the coronary arteries of patients ... Angioscopy is a medical technique for visualizing the interior of blood vessels. In this technique, a flexible fiberoptic ... Forrester JS, Litvack F, Grundfest W, Hickey A (1987). "A perspective of coronary disease seen through the arteries of living ...
The coronary arteries start in the right and left aortic sinus and provide blood to the heart muscle in a similar fashion to ... Common ostriches develop via Intussusceptive angiogenesis, a mechanism of blood vessel formation, characterizing many organs.[ ... It then moves along the coronary groove and continues on into the tissue as interventricular branches toward the apex of the ... The deep branches of the coronary arteries found within the heart tissue are small and supply the interventricular and right ...
The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification.[23] Moreover, the ... Heart and Vessels. 25 (1): 1-6. doi:10.1007/s00380-009-1151-4. PMID 20091391.. ... in the association of coronary calcified plaque in that there is less calcified atherosclerotic plaque in the coronary arteries ... "Active serum vitamin D levels are inversely correlated with coronary calcification". Circulation. 96 (6): 1755-60. doi:10.1161/ ...
venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... Heart valves separate the atria from the ventricles, or the ventricles from a blood vessel. Heart valves are situated around ... As they mature, they rotate slightly as the outward vessels spiral, and move slightly closer to the heart.[8] ... The heart also has a coronary sinus valve, and an inferior vena cava valve, not discussed here. ...
Coronary perfusion pressures are decreased by these factors, which also increase myocardial oxygen consumption, possibly ... Cerebral autoregulation is the ability of the blood vessels in the brain to maintain a constant blood flow. People who suffer ... Excessive reduction in blood pressure can precipitate coronary, cerebral, or renal ischemia and, possibly, infarction. ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ...
Cardiac vessels. CHD. Angioplasty. Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent ... shunt from blood vessel to blood vessel. systemic circulation to pulmonary artery shunt Blalock-Taussig shunt. SVC to the right ... shunt from heart chamber to blood vessel. atrium to pulmonary artery Fontan procedure. left ventricle to aorta Rastelli ... for transposition of great vessels Jatene procedure. Mustard procedure. for univentricular defect Norwood procedure. Kawashima ...
Padmanaban, P.; Toora, B. (2011). "Hemoglobin: Emerging marker in stable coronary artery disease". Chronicles of Young ... especially the delicate blood filtering vessels of the kidneys, causing kidney damage. Iron is removed from heme and salvaged ... A recent study done in Pondicherry, India, shows its importance in coronary artery disease.[83] ... degraded hemoglobin protein or hemoglobin that has been released from the blood cells too rapidly can clog small blood vessels ...
An anastomosis is the connection of two normally divergent structures.[2] It refers to connections between blood vessels or ... coronary arteries and cortical branch of cerebral arteries). Anastomoses also form alternative routes around capillary beds in ... An example of surgical anastomosis occurs when a segment of intestine, blood vessel, or any other structure are connected ... such as between blood vessels, leaf veins, or streams. Such a connection may be normal (such as the foramen ovale in a fetus's ...
In men, coronary disease is more frequent, while in women, high systolic blood pressure and valvular heart disease are more ... Also, people with a higher risk of AF, e.g., people with pre-operative hypertension, more than three vessels grafted, or ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ... Cardiovascular factors known to be associated with the development of AF include high blood pressure, coronary artery disease, ...
Phase III Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease ...
CCBs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in ... reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina. They have minimal ... Since lymphatic drainage relies on contraction of the skeletal smooth muscle inside the lymphatic vessel[18] supported by ...
... or small blood vessels in the kidneys.[6][7][8] ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. ...
Right and left coronary arteries.. Arch of aorta (supra-aortic vessels): Brachiocephalic trunk. Left common carotid artery. ... For this reason the left, right and posterior aortic sinuses are also called left-coronary, right-coronary and non-coronary ... The aorta ends by dividing into two major blood vessels, the common iliac arteries and a smaller midline vessel, the median ... Combination of coronary sinus, superior vena cava and inferior vena cava. Supplies. The systemic circulation. (entire body with ...
Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in pulmonary edema and acute ... It is the second-leading cause of death in non-coronary intensive care unit (ICU) and the tenth-most-common cause of death ... a deficiency of chemicals that constrict blood vessels such as vasopressin, and activation of ATP-sensitive potassium channels. ... and interleukin 6 may activate procoagulation factors in the cells lining blood vessels, leading to endothelial damage. The ...
"Navy Announces Research Vessel to be Named in Honor of Neil Armstrong". United States Navy. September 24, 2012. Archived from ... Armstrong underwent bypass surgery on August 7, 2012, to relieve coronary artery disease.[210] Although he was reportedly ... Navy announced that the first Armstrong-class vessel would be named RV Neil Armstrong. Delivered to the Navy on September 23, ...
Firstly, the flow through the blood vessel may be disrupted due to the accumulation of blood under the vessel wall, leading to ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... the small blood vessels that supply the outer layer of larger blood vessels.[1][2] Various theories exist as to whether people ... inside the blood vessel). This may be performed to allow the blood to flow through a severely narrowed vessel, or to seal off ...
... s separate the atria from the ventricles, or the ventricles from a blood vessel. Heart valves are situated around ... The heart also has a coronary sinus valve, and a inferior vena cava valve, not discussed here. ... As they mature, they rotate slightly as the outward vessels spiral, and move slightly closer to the heart.[8] ...
A catheter is inserted into a blood vessel, typically the femoral artery, and passed through blood vessels into the cerebral ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... When a patient has an aneurysm involving a blood vessel or a tumor at the base of the skull wrapping around a blood vessel, ... where small communicating vessels link the main cerebral vessels. These areas are particularly susceptible to saccular ...
Heart and blood vessels[edit]. VIGOR study and publishing controversy[edit]. The VIGOR (Vioxx GI Outcomes Research) study, ... or coronary artery bypass). ... 2.1 Heart and blood vessels *2.1.1 VIGOR study and publishing ... Merck has stated that there was no effect on prostacyclin production in blood vessels in animal testing.[13] Corey speculated ...
... is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in ... Are coronary heart disease and peripheral arterial disease associated with tobacco or cannabis consumption ... When blood vessels constrict, the flow of blood is restricted or decreased, thus retaining body heat or increasing vascular ... The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in staunching ...
Coronary vessel wall images were readily acquired in all subjects. Both coronary vessel wall thickness (1.5±0.2 versus 1.0±0.2 ... measurements of coronary wall thickness suggests that MR coronary vessel wall imaging is able to assess coronary vessel wall ... free-breathing coronary vessel wall imaging approach using a dual IR TSE sequence and to compare coronary vessel wall and lumen ... small coronary vessel wall thickness, and low contrast-to-noise ratios (CNRs) between the coronary vessel wall and the ...
Coronary Vessels Lab, PBL, POD, and PA Meeting Today was a really great day. I think the coronary vessels lab that we did this ... When the contrast agent was injected, we were able to watch on the screen as it went through the coronary arteries. We were ... Angiogenesis is the process of growing new blood vessels.) It was fairly interesting, but of course last weeks talk was a very ... and I was surprised to learn that there are different catheters for the right coronary artery versus the left. It makes sense, ...
Coronary Vessels; Humans; Coronary Circulation; Retrospective Studies; Recurrence; Coronary Disease; Necrosis; Stents; Follow- ... There were no significant differences between groups, concerning type of stented coronary vessel (left anterior descending-LAD ... Implantation of the Palmaz-Schatz stent in coronary vessels irrigating and non-irrigating necrotic myocardial areas: comparison ... Implantation of the Palmaz-Schatz stent in coronary vessels irrigating and non-irrigating necrotic myocardial areas: comparison ...
The left coronary artery and the right coronary artery.. The left coronary artery begins with the left main stem, which then ... Blood Vessels and Coronary Arteries. To view this video please enable JavaScript, and consider upgrading to a web browser that ... of blood vessels, the architecture of the blood vessels and the histology. ... All of our vessels basically are built in three layers.. And if we have a close look at those layers, we see in the innermost ...
System to assess coronary branch vessels in addition to main coronary arteries in patients with suspected coronary artery ... Rcadia COR Analyzer System Receives Expanded FDA Clearance to Rule Out Coronary Artery Disease in Coronary Branch Vessels. News ... Rcadia COR Analyzer System Receives Expanded FDA Clearance to Rule Out Coronary Artery Disease in Coronary Branch Vessels ... provides a high negative predictive value for the absence of coronary disease in branch vessels as well as the major coronary ...
Here we present for the first time a case reporting on the placement of coronary stent graft in a peripheral vessel for the ... angiologists or radiologists may consider such an option for complication management after injury of smaller vessels during ... Successful Implantation of a Coronary Stent Graft in a Peripheral Vessel. Alexander Hess. ,1 Britta Vogel. ,1 Benedikt Kohler. ... Here we present for the first time a case reporting on the placement of coronary stent graft in a peripheral vessel for the ...
Blood flow is provided to a distal portion of the artery through an adjacent venous vessel so that blood can be provided to ... The bypass system couples a restricted artery to a venous vessel distal of a restriction to provide blood flow through the ... A bypass system for bypassing a restriction in a parent vessel of a mammal to provide blood flow past the restriction. ... Coronary artery 16 includes restriction 22. Veins 20 are arranged adjacent to coronary arteries 16. Coronary arteries 16 carry ...
... is working on a radical new theory for the treatment of damaged coronary arteries. He ... Thinking Outside the Vessel: New Gel to Heal Coronary Arteries. June 26th, 2007 Josh Umbehr Cardiology ... The vessels can also be connected with a plastic tube, or shunt.. However, the surgical trauma can damage the endothelium and ... The vessel walls then scar and thicken, leading to restenosis.. The Pervasis product contains endothelial cells grown from ...
Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI) (RIVER-PCI). The safety and ... design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER- ... Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization ... Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, ...
... stenoses in one or more coronary arteries with reference vessel diameter of at least 2.0 mm, whether in the target vessel or in ... Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI) (RIVER-PCI). The safety and ... Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI). Official Title ICMJE A Phase ... a non-target vessel regardless of the presence or absence of coronary collaterals. In the case of a participant post-coronary ...
At coronary angiography, left anterior descending coronary artery was occluded with distal perfusion by collateral flow, and ... 6619704 - Coronary angiographic assessment of left posterior hemiblock.. 20443654 - Three-vessel coronary artery disease with ... Coronary Aneurysm / complications*, diagnosis*, therapy. Coronary Angiography. Coronary Artery Disease / complications*, ... right coronary artery with diffuse coronary atherosclerosis were present. Coronary thrombosis was also present into LCX ...
... acute coronary syndrome (ACS) vs. chronic coronary syndrome (CCS), and extent of vessel involvement (single vs. multi-vessel ... Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial.. Montorsi P1, Ravagnani PM ... single-vessel (OR=2.53; 95% CI, 1.43-4.51; P=0.0002), and CCS vs. ACS (OR=2.32; 95% CI, 1.22-4.41; P=0.01) were independent ... 285 patients with CAD divided into three age-matched groups: group 1 (G1, n=95), ACS and one-vessel disease (1-VD); group 2 (G2 ...
Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans.. Lerman A1, Burnett JC Jr, ... Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in ... Twenty-six patients without significant coronary artery disease on coronary angiography and intravascular ultrasound were ... reverses coronary endothelial dysfunction to acetylcholine in humans with nonobstructive coronary artery disease. ...
Learn more about Single Coronary Vessel Disease from related diseases, pathways, genes and PTMs with the Novus Bioinformatics ... Single Coronary Vessel Disease: Disease Bioinformatics. Single Coronary Vessel Disease is the progression of atherosclerosis in ... Single Coronary Vessel Disease is also known as Single Vessel Coronary Artery Disease. ... Single Coronary Vessel Disease has been studied in relation to diseases such as: *Coronary Artery Disease ...
Coronary Heart Disease. Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary ... B, Progression of disease in nonculprit vessel. Mild disease is observed in mid right coronary artery (middle left) at the time ... A, Progression of disease in nonculprit vessel resulting in MI (top left). Distal right coronary artery lesion (solid arrows), ... Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention ...
Proepicardial Origin of Developing Coronary Vessels. Paul Palmquist-Gomes a,b, José María Pérez-Pomares a,b, Juan Antonio ... Device to Narrow the Coronary Sinus in Refractory Angina Images subject to Copyright. to reprint, please follow this link. ...
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique ... Many people who have coronary artery disease and are at risk of having a heart attack undergo angioplasty, a procedure that ... Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique Brief description of study. ... An OFDI is a new type of catheter that takes more detailed pictures of blood vessel walls and plaques. The additional detail ...
In this mini-review, we highlight the most recently identified loci that have predicted roles in the vessel wall and provide ... In this mini-review, we highlight the most recently identified loci that have predicted roles in the vessel wall and provide ... the majority of the annotated genes at these loci encode for proteins involved in vessel wall function with no known drugs ... the majority of the annotated genes at these loci encode for proteins involved in vessel wall function with no known drugs ...
Selective coronary angiography revealed SCAD involving all three vessels. Right coronary angiogram showed linear dissection ... Spontaneous triple vessel coronary artery dissection in a patient with effort angina ... Spontaneous triple vessel coronary artery dissection in a patient with effort angina ... spontaneous three vessel coronary dissection associated with typical effort angina has never been reported. This case ...
Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in ... Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans Circulation. 1998 Jun 2;97( ... Conclusions: Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial ... Methods and results: Twenty-six patients without significant coronary artery disease on coronary angiography and intravascular ...
... coronary, en, heart, human, science, supply, vessels , Glogster EDU - Interactive multimedia posters ... ooo times daily*Transports blood 60,000 miles through a network of blood vessels* Located in the chest cavity in a region ...
We examined the influence of vessel size using an intention-to-treat approach in 259 patients who underwent stent implantation ... Blood Vessel Prosthesis Implantation*. Coronary Angiography. Coronary Disease / etiology, surgery*. Coronary Vessels / ... In the stented population, smaller vessel size was associated with a higher stent:vessel ratio, a greater relative gain and a ... 9231549 - Coronary artery stenting in acute myocardial infarction.. 19205549 - Left main coronary artery stenosis treatment ...
... Dahm, Peter L. ; Bodelsson, Mikael LU ; ... The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS: Epicardial coronary arteries ... The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS: Epicardial coronary arteries ... The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS: Epicardial coronary arteries ...
Percutaneous Intervention in Small-Vessel Coronary Disease Message Subject (Your Name) has forwarded a page to you from JACC: ...
Predictors for New Native-Vessel Occlusion in Patients with Prior Coronary Bypass Surgery: A Single-Center Retrospective ... Predictors for New Native-Vessel Occlusion in Patients with Prior Coronary Bypass Surgery: A Single-Center Retrospective ...
Mesenteric vessels: This includes Acute mesenteric ischemia Chronic mesenteric ischemia Mesenteric thrombosis Dissection or any ... resulting in gastrointestinal symptoms Stenting of the mesenteric vessels is covered only when angioplasty of the vessels would ... Non-Coronary Vascular Stents: Mesenteric Vessels. by Find-A-Code. January 29th, 2018 ... Stenting of the mesenteric vessels is covered only when angioplasty of the vessels would not suffice and after the patient has ...
What is Coronary blood vessels? Meaning of Coronary blood vessels medical term. What does Coronary blood vessels mean? ... Looking for online definition of Coronary blood vessels in the Medical Dictionary? Coronary blood vessels explanation free. ... Coronary blood vessels. Coronary blood vessels. The arteries and veins that supply blood to the heart muscle. ... By carrying this gene vector into the coronary circulation, it should help the cells that form coronary blood vessels grow.. ...
Evidence on how to choose target vessels of percutan... ... Long-term outcomes of percutaneous coronary intervention in ... grafts and native vessels in coronary artery bypass grafting patients with diabetes mellitus. J Thorac Dis. 2019 Nov;11(11): ... Long-term outcomes of percutaneous coronary intervention in grafts and native vessels in coronary artery bypass grafting ... Long-term outcomes of percutaneous coronary intervention in grafts and native vessels in coronary artery bypass grafting ...
ED prevalence differs across subsets of patients with CAD and is related to coronary clinical presentation and extent of CAD. ... acute coronary syndrome (ACS) vs. chronic coronary syndrome (CCS), and extent of vessel involvement (single vs. multi-vessel ... Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial Eur Heart J. 2006 Nov;27(22 ... single-vessel (OR=2.53; 95% CI, 1.43-4.51; P=0.0002), and CCS vs. ACS (OR=2.32; 95% CI, 1.22-4.41; P=0.01) were independent ...
Inner and outer coronary vessel wall segmentation from CCTA using an active contour model with machine learning-based 3D voxel ... In this paper, we present a fully automated approach to coronary vessel segmentation, which involves calcification or soft ... Adequately virtualizing the coronary lumen plays a crucial role for simulating blood ow by means of fluid dynamics while ... The regression model provides a strong estimate of the distance to the true vessel surface for every surface candidate point ...
Take 5: Heart Vessel Stents (Percutaneous Coronary Intervention or PCI) - Carl L. Tommaso, MD, NorthShore University Health ... Take 5: Heart Vessel Stents (Percutaneous Coronary Intervention or PCI) - Carl L. Tommaso, MD, NorthShore University Health ...
  • The aim of this study was to assess the acute results and angiographic restenosis following coronary artery stenting of infarct-related (Group 1) and non infarct-related coronary arteries (Group 2). (
  • In conclusion, this study indicates that stenting of infarct and non infarct-related coronary arteries has similar success and 6-month restenosis rates. (
  • Coronary arteries are the blood vessels that supply oxygen-rich blood to the heart muscle. (
  • Coronary artery disease can cause plaque to build up inside the walls of the coronary arteries. (
  • To evaluate the effect of adenosine (Ado) on K + induced relaxation of vascular smooth muscle, helical strips of cat coronary arteries, suspended in an organ bath of Kreb's solution (37° C, 95% O 2 and 5% CO 2 ), were studied during isometric contraction stimulated by acetylcholine (ACh). (
  • The right coronary artery splits into the acute marginal arteries and the right posterior coronary artery . (
  • Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy. (
  • Thus, the presence of adenosine potentiated the relaxation of ACh stimulated active tension by incremental elevation of [K + ]. This finding supports the concept that vasoactive agents may interact to relax arterial smooth muscle, and may have implications regarding local coronary blood flow regulation. (
  • This finding supports the concept that vasoactive agents may interact to relax arterial smooth muscle, and may have implications regarding local coronary blood flow regulation. (
  • We retrospectively analyzed the results of 381 consecutive patients treated with Palmaz-Schatz coronary stent implantation between May 1992 and January 1996. (
  • The stent remains in the blood vessel, allowing the blood to flow normally again. (
  • Recent evidence suggests that higher restenosis rate is observed after coronary angioplasty of an infarct-related artery. (
  • A procedure called angioplasty can widen a narrowed or blocked coronary artery. (
  • These X-rays show a blocked coronary artery before and after an angioplasty procedure. (
  • This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. (
  • Both groups had similar age, gender, clinical conditions and coronary angiographic pattern. (
  • Coronary artery anomalies are defects or abnormalities in the artery. (
  • This book surveys coronary vasculature from its embryonic origins through postnatal growth, adulthood and senescence, with chapters on normal coronary development, anomalies, adaptations to exercise training, aging, hypoxia, myocardial ischemia and more. (
  • Coronary anomalies. (
  • Acute coronary stenting success and major adverse events (acute myocardial infarction, emergency bypass, death) were similar in both groups of patients. (
  • There were no significant differences between groups, concerning type of stented coronary vessel (left anterior descending-LAD 52.4% vs non-LAD 47.6%, Group 1, LAD 59.5% vs non-LAD 40.5%, Group 2) and number of stents per patient (1.31 +/- 0.48 in Group 1, 1.18 +/- 0.56 in Group 2) and per coronary vessel (1.17 +/- 0.54 in Group 1, 1.09 +/- 0.46 in Group 2). (
  • For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. (
  • Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. (
  • The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come. (
  • In Switzerland alone, the risk to develop a coronary heart disease during life time is around 25% for men and 18% for women. (
  • The investigators noted that the 'high negative predictive value will be most useful in a population with a low prevalence of coronary disease - such as the emergency room chest pain population - where the COR Analyzer might be used to facilitate the rapid discharge of a majority of patients who have normal coronary CTA studies during all hours of the day or night. (
  • The company's first FDA-cleared product, the COR Analyzer® System, provides fully automated, real-time analysis of Coronary CT angiography to enable the practical application of cCTA in detecting significant coronary artery disease. (
  • Methods and Results -Ten subjects, including 5 healthy adult volunteers (aged 35±17 years, range 19 to 56 years) and 5 patients (aged 60±4 years, range 56 to 66 years) with x-ray-confirmed coronary artery disease (CAD), were studied with a T2-weighted, dual-inversion, fast spin-echo MR sequence. (
  • Three-vessel coronary artery disease with multi-vessel proximal aneurysms. (
  • Association between erectile dysfunction and coronary artery disease. (
  • To investigate the prevalence of erectile dysfunction (ED) in patients with CAD according to clinical presentation, acute coronary syndrome (ACS) vs. chronic coronary syndrome (CCS), and extent of vessel involvement (single vs. multi-vessel disease). (
  • Erectile dysfunction: a marker of silent coronary artery disease. (
  • Thus, the present double-blind, randomized study was designed to test the hypothesis that long-term, 6-month supplementation of L-arginine, the precursor of the endothelium-derived vasodilator NO, reverses coronary endothelial dysfunction to acetylcholine in humans with nonobstructive coronary artery disease. (
  • Twenty-six patients without significant coronary artery disease on coronary angiography and intravascular ultrasound were blindly randomized to either oral L-arginine or placebo, 3 g TID. (
  • This study proposes a role for L-arginine as a therapeutic option for patients with coronary endothelial dysfunction and nonobstructive coronary artery disease. (
  • Submit your Twitter account related to Single Coronary Vessel Disease to be featured! (
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  • Single Coronary Vessel Disease is the progression of atherosclerosis in one vessel of the heart. (
  • The symptoms of Single Coronary Vessel Disease include chest tightness, fatigue, and shortness of breath. (
  • Single Coronary Vessel Disease is treated with blood thinning medications, bypass surgery, and angioplasty. (
  • There are some people who are at greater risk for Single Coronary Vessel Disease, but lifestyle changes can improve the outlook for patients. (
  • Explore more on Single Coronary Vessel Disease below! (
  • We have 1206 products for the study of Single Coronary Vessel Disease that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits. (
  • Single Coronary Vessel Disease is also known as Single Vessel Coronary Artery Disease. (
  • Greater coronary artery disease burden confers a significantly higher risk for clinical plaque progression. (
  • Although the modification of systemic risk factors for further progression of atherosclerosis has reduced the incidence of death and myocardial infarction (MI) by ≈30%, a subset of patients continue to have recurrent symptoms related to coronary artery disease progression and lesion instability. (
  • The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. (
  • The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. (
  • Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile. (
  • Kharrazi H, Vaisi-Raygani A, Sabokroh AR, Pourmotabbed T (2006) Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. (
  • Vaisi-Raygani A, Rahimi Z, Nomani H, Tavilani H, Pourmotabbed T (2007) The presence of apolipoprotein ε4 and ε2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. (
  • Vaisi Raygani A, Rahimi Z, Tavilani H, Pourmotabbed T (2010) Butyrylcholinesterase K variant and the APOE-ε4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients. (
  • Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A (2007) Prevalence of coronary artery disease risk factors in Iran: a population based survey. (
  • This study will use a new imaging technique called optical frequency domain imaging (OFDI) to examine the presence of vulnerable plaques in people with coronary artery disease. (
  • Many people who have coronary artery disease and are at risk of having a heart attack undergo angioplasty, a procedure that opens a narrowed or blocked blood vessel. (
  • This study will enroll people with coronary artery disease who are undergoing angioplasty. (
  • Coronary artery disease (CAD) is the leading cause of mortality worldwide and poses a considerable public health burden. (
  • Coronary artery disease (CAD) is a maladaptive inflammatory disease of the coronary artery vessel wall that remains one of the leading causes of death worldwide. (
  • Spontaneous coronary artery dissection (SCAD) is a rare but often fatal cause of ischaemic heart disease occurring predominantly in young or middle aged, otherwise healthy subjects. (
  • Coronary artery bypass grafting is performed for patients with coronary artery disease (CAD) to improve quality of life and to reduce cardiac-related mortality. (
  • There is a general agreement that already in the early postoperative period CABG surgery improves the disease in patients with symptomatic left main coronary artery stenosis or stenosis of the three main coronary vessels. (
  • Methods: One hundred and fifty-seven patients with diabetes and previous CABG, who underwent PCI of either a graft vessel (GV) (n=44) or a native vessel (NV) (n=113) in the National Center for Cardiovascular Disease, China, were studied. (
  • AbstractPurpose of ReviewTo review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). (
  • Coronary artery disease (CAD) involving the LM is associated with high morbidity and mortality. (
  • In this study, we review the current literature in the management of patients with DM and coronary artery disease undergoing a revascularization procedure.RésuméLes patients atteints de diabète sucré (DS) sont exposés à un risque accru de coronaropathie. (
  • We attempted to systematically assess various microvascular cutaneous flow indices in response to reactive hyperaemia in control subjects and in patients with coronary artery disease (CAD), and to correlate these with brachial artery flow-mediated dilation (FMD). (
  • Objectives The aim of this study was to investigate the impact of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) on clinical outcomes in patients with de novo 3-vessel disease (3VD) treated with contemporary PCI. (
  • What are the effects of dalcetrapib on endothelial function, blood pressure, inflammatory markers, and lipids in patients with, or at risk of, coronary heart disease (CHD)? (
  • Group 1 consisted of 10 patients who had new onset of refractory rest angina and ischemic ST-T changes, but no infarction, single-vessel coronary disease without collateralization, and normal left ventricular (LV) angiograms. (
  • Lipid and protein oxidation and antioxidant status in patients with angiographically proven coronary artery disease. (
  • Paraoxonase and arylesterase activities in coronary artery disease. (
  • Heart rate: a strong predictor of mortality in subjects with coronary artery disease. (
  • Long-term survival in patients with coronary artery disease: importance of peripheral vascular disease. (
  • Coronary artery disease in diabetic patients]. (
  • Background: The Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial was a non-inferiority trial that compared percutaneous coronary intervention (PCI) using first-generation paclitaxel-eluting stents with coronary artery bypass grafting (CABG) in patients with de-novo three-vessel and left main coronary artery disease, and reported results up to 5 years. (
  • Patients with de-novo three-vessel and left main coronary artery disease were randomly assigned (1:1) to the PCI group or CABG group. (
  • Prespecified subgroup analyses were performed according to the presence or absence of left main coronary artery disease and diabetes, and according to coronary complexity defined by core laboratory SYNTAX score tertiles. (
  • Among patients with three-vessel disease, 151 (28%) of 546 had died after PCI versus 113 (21%) of 549 after CABG (hazard ratio 1·41 [95% CI 1·10-1·80]), and among patients with left main coronary artery disease, 93 (26%) of 357 had died after PCI versus 98 (28%) of 348 after CABG (0·90 [0·68-1·20], pinteraction=0·019). (
  • However, CABG provided a significant survival benefit in patients with three-vessel disease, but not in patients with left main coronary artery disease. (
  • Patients with multi-vessel coronary artery disease (CAD) are selected for percutaneous coronary interventions (PCI) or surgical revascularisation. (
  • Objectives This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. (
  • Objectives We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients. (
  • Serum biomarkers of inflammation have emerged as independent predictors of coronary artery disease (CAD). (
  • Background Among patients with acute myocardial infarction ( MI ) who have multivessel disease, it is unclear if multivessel percutaneous coronary intervention ( PCI ) improves clinical and quality‐of‐life outcomes compared with culprit‐only intervention. (
  • Prior observational studies and small randomized studies demonstrated reduced major adverse cardiovascular events, including cardiac death, myocardial infarction, and recurrent angina, as well as repeated revascularization, with multivessel percutaneous coronary intervention among patients seen with ST‐segment elevation myocardial infarction and multivessel disease. (
  • We have shown that among patients seen with acute myocardial infarction and multivessel disease, performing multivessel percutaneous coronary intervention is associated with lower risk of unplanned readmissions in the short‐term after discharge, but similar angina and quality‐of‐life scores. (
  • Multivessel coronary artery disease is present among 40% of patients who are seen with ST‐segment elevation myocardial infarction (STEMI) 1 , 2 and up to 70% of those who are seen with non-ST‐segment elevation myocardial infarction (NSTEMI). (
  • Expected cost-effectiveness of percutaneous coronary intervention versus bypass surgery for the treatment of left main, three vessel, and multi-vessel disease that involves the ostium of the right coronary artery. (
  • Objective: The aim of this study is to present the cost-effectiveness of the percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for the following three study populations: patients with left main (LM) and/ or three vessel disease, and multi-vessel treatment involving the right coronary artery (RCA) with aorto-ostial region. (
  • To investigate the accuracy of the 12-lead ECG in localizing the site of coronary artery narrowings, we reviewed abnormal ECGs obtained during myocardial infarction, spontaneous angina or exercise stress testing in 134 patients with angiographically documented one-vessel disease. (
  • These findings should lead to a better understanding of the value and limitations of the 12-lead ECG in localizing coronary artery disease. (
  • Methods: A total of 254 patients with coronary artery disease who underwent three-vessel OCT were divided into tertiles according to FRS. (
  • Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study. (
  • Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. (
  • In addition, atherosclerosis is a spatially heterogeneous disease and therefore imaging at multiple anatomical levels of the coronary circulation is mandatory. (
  • When the need for regeneration arises, for example in the setting of coronary artery disease, a reactivation of embryonic processes ensues, redeploying many of the same molecular regulators. (
  • Does Cardiovascular disease relates to disorders of the heart blood vessels and the lung function? (
  • No, Cardiovascular disease relates to disorders of the heart, and blood vessels but not lungs. (
  • Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-coronary artery bypass for one-vessel proximal left anterior descending coronary artery disease. (
  • Our aim was to describe outcomes with medical therapy, angioplasty, or left internal mammary artery (LIMA) bypass grafting in patients with 1-vessel, proximal LAD disease. (
  • Treatment of 1-vessel, proximal LAD disease with medicine, angioplasty, or UMA bypass resulted in comparable adjusted survival. (
  • However, there is limited data comparing CMR and FFR in patients with multi-vessel disease. (
  • This study aims to evaluate the correlation between myocardial ischemia detected by CMR with FFR in patients with multivessel coronary disease at angiography. (
  • There is good concordance between perfusion CMR and FFR for the identification of myocardial ischemia in patients with multi-vessel disease. (
  • However, some discrepancy remains and at this stage it is unclear whether CMR underestimates or FFR overestimates the number of ischemic segments in multi-vessel disease. (
  • However, there are limited data on their comparability in defining ischemic segments in patients with multi-vessel disease. (
  • 9 ] compared SPECT and perfusion CMR in patients with angiographically proven three vessel disease and showed that CMR detected perfusion defects in all three vascular territories in 57 % of patients vs only 11 % with SPECT. (
  • It is unknown, whether the use of a high-resolution perfusion technique such as CMR leads to improved concordance for the identification of ischemic segments in multi-vessel disease in comparison with FFR. (
  • The aim of this study was to compare the extent of myocardial ischemia based on CMR and FFR in patients with angiographically defined multi-vessel disease. (
  • CONCLUSIONS: We conclude that in patients with relevant coronary artery disease, plaque burden and the amount of necrotic core material are greater in the target vessel. (
  • Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden coronary death. (
  • The prevalence of these ischemic heart disease levels in fractional flow reserve (FFR) interrogated vessels remains largely unknown. (
  • Integration of FFR, CFR, and IMR supports the existence of differentiated patterns of ischemic heart disease that combine focal and diffuse coronary narrowings with variable degrees of MCD. (
  • The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, urgent, and emergency settings. (
  • American guidelines also advocate the institution of the Heart Team, indicating the need for multidisciplinary discussion in patients with left main coronary artery disease (CAD) or complex multivessel CAD. (
  • Diabetes causes microvascular and macrovascular complications including coronary artery disease (CAD) that ultimately contributes to a high rate of cardiovascular morbidity and mortality. (
  • 3. Haffner SM Lehto S Ronnemaa T Pyorala K Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. (
  • 6. Scognamiglio R Negut C Ramondo A Tiengo A Avogaro A. Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus. (
  • Severity of coronary artery disease in type 2 diabetes mellitus: Does the timing matter? (
  • Revascularization for coronary artery disease in diabetes mellitus: Angioplasty stents and coronary artery bypass grafting. (
  • Current Status of Bioresorbable Scaffolds in the Treatment of Coronary Artery Disease. (
  • Combining information from the coronary artery calcium score with information from conventional risk factors to estimate coronary heart disease risk. (
  • Studies comparing CV-PCI versus MV-PCI in patients with multivessel coronary artery disease were screened for inclusion in final analysis. (
  • Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. (
  • The resulting probabilities in the four test groups were then compared with the angiographic findings of triple-vessel/left main coronary artery disease. (
  • The findings suggest that a clinician could expect to avert at least 10 angiograms on patients with less severe disease for every missed case of triple-vessel/left main coronary artery disease by using these probabilities as a basis for the decision to perform angiography. (
  • Diabetes mellitus, hypertension, hyperlipidemia and cigarette smoking are major coronary artery disease risk factors. (
  • This descriptive study was performed on 196 patients with coronary artery disease who underwent coronary angiography in Shafa hospital of Kerman during a six-month period. (
  • In our study, hypertension and diabetes mellitus were the main risk factors for the presence of three vessel disease. (
  • The objectives of this investigation are to evaluate the rheologic properties in atherosclerotic disease treated with the various coronary artery bypass graft (CABG) models by numerical analysis, we used four different CABG models for the assessment of spatial fluctuation in wall shear stress, pressure variation and mass flow rate with Carreau model and Navier-Stokes equation. (
  • Elevated mean platelet volume (MPV) has been proposed as a risk factor for coronary artery disease (CAD) and is associated with poor clinical outcome in acute coronary syndrome (ACS). (
  • The relation between chronic obstructive pulmonary disease and coronary collateral vessels. (
  • The relation between microalbuminuria and coronary collateral vessel development in patients with unstable coronary artery disease. (
  • Statins have long been used to help prevent coronary artery disease, but doctors have recently found that they also have short-term benefit for people with an acute coronary syndrome. (
  • Association of endotheline receptor gene rs1878406 polymorphism with severe multi-vessel coronary disease]. (
  • To assess the association of single nucleotide polymorphisms (SNPs) of endotheline receptor gene with the severity of coronary heart disease (CHD). (
  • A total of 553 CHD patients, including 324 patients with mult-vessel disease based on result of selected coronary angiography, and 553 age- and sex-frequency matched controls were selected. (
  • After adjusting for conventional risk factors by logistic regression analysis, the results suggested that the distribution of rs1878406 TT+TC genotype in severe multi-vessel disease group is significantly higher than that in the control group (OR=1.43, 95% CI: 1.05-2.07, P=0.033). (
  • The above results suggested that the rs1878406 polymorphism of endotheline receptor gene may serve as a genetic marker for severe multi-vessel disease in CHD among ethnic Han Chinese. (
  • Coronary vessel formation in development and disease: mechanisms and insights for therapy. (
  • The authors describe a case of left main coronary artery originating from the right sinus of Valsalva, associated to disease of multiple vessels. (
  • Background- With the reduction in restenosis rates by drug-eluting stents, there is new controversy concerning the optimal management of incidental, nontarget lesions identified during percutaneous coronary intervention (PCI). (
  • Success stories range from hydrophilic coatings that increase lubricity of catheters passed through peripheral blood vessels to access the heart, to drug-eluting coatings on stents that keep coronary blood vessels patent (open). (
  • The SYNTAX-II strategy includes: heart team decision-making utilizing the SYNTAX Score II (a clinical tool combining anatomical and clinical factors), coronary physiology guided revascularisation, implantation of thin strut bioresorbable-polymer drug-eluting stents, intravascular ultrasound (IVUS) guided stent implantation, contemporary chronic total occlusion revascularisation techniques and guideline-directed medical therapy. (
  • Stenoses can be treated with the insertion of stents, small lattice tubes that support the vessels from the inside and keep them open in order to allow the blood to flow through. (
  • Heart specialists at the University Hospital in Tübingen have developed an alternative approach that combines the advantages of uncoated stents with the advantage of homogenous drug transfer to the vessel wall as a whole, thereby also avoiding the potential disadvantages of coated stents. (
  • Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. (
  • This case illustrates coronary angiography and intravascular ultrasound images in a patient with SCAD involving all three vessels and treated by stenting. (
  • The purpose of this study was to examine the relationship between conventional cardiovascular risk factors, Lp-PLA2 concentration and plaque structure parameters as assessed by intravascular ultrasound in patients with either stable angina or acute coronary syndromes due to intermediate single-vessel coronary artery lesions. (
  • Invasive x-ray coronary angiography and bright-blood 2 3 coronary magnetic resonance angiography (MRA) only allow for assessment of luminal vessel diameter and do not provide direct information regarding coronary vessel wall thickness or atherosclerotic plaque. (
  • The dense binding to vasa vasorum in the saphenous vein suggests a role for 5-HT in closure of these nutrient vessels, which could contribute to the formation of atherosclerotic changes in saphenous vein grafts. (
  • Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. (
  • Using TI less than TI*, Fig. 3 shows that PS-DIR enables delineation of the coronary artery vessel wall and supports an increased wall-lumen contrast when compared with the conventional DIR in which TI was too short for adequate blood signal-nulling. (
  • Role of coronary clinical presentation and extent of coronary vessels involve. (
  • Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. (
  • ED prevalence differs across subsets of patients with CAD and is related to coronary clinical presentation and extent of CAD. (
  • There was no difference between the two study groups in clinical characteristics or in the coronary blood flow in the response to acetylcholine at baseline. (
  • 5,6 However, the incidence of clinical plaque progression in a large, contemporary cohort of patients treated with culprit vessel PCI and medical therapy for secondary prevention is unknown. (
  • Twelve-month clinical results after treatment of SCB demonstrated low rates of MACE in this small vessel cohort of the NANOLUTE' registry, hence showing an adequate efficacy and safety in this setting. (
  • Conclusions We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. (
  • The neutral results of numerous clinical trials that have evaluated the efficacy of angiogenic therapy to revascularize the infarcted heart reflect our poor understanding of the processes required to form a functional coronary vasculature. (
  • In this paper, we are presenting a patient who presented to the emergency department (ED) with chest pain due to Acute Coronary Syndrome (ACS) that was found to be due to multi-vessels CAAs involving the left main as well as RCA, Left Anterior Descending (LAD) artery and Left Circumflex Artery (LCA) requiring urgent Coronary Artery Bypass Grafting (CABG). (
  • We postulate that myocardial active hyperemia is limited either because the coronary vessels remaining after chronic circumflex occlusion cannot dilate sufficiently or that there is inappropriate active vasoconstriction during severe exertion. (
  • Therefore, the prognosis of patients who were successfully treated for vessel perforation via ELCA without CABG is not fully addressed. (
  • The all comers, multicentre Nanolute registry enrolled patients with lesions located in coronary vessels with reference vessel diameter (RVD) ≤ 2.75 mm. (
  • On the examination report, (a) the original image, (b) the center-line image and (c) the plotted diameter along the center-line for the obtained vessel segments are arranged. (
  • Publications] 柳原 圭雄: 'A Study of Magnification and Smoothing effect on Accurate Computerized Measurement of vessel diameter of coronary cineangiograms using a tele-cine converter' MEDICAL IMAGING TECHNOLOGY. (
  • Publications] Y.Yanagihara: 'A Study of Magnification and Smoothing Effect on Accurate Computerized measurement of Vessel Diameter of Coronary Cineangiograms using a tele-cine converter. (
  • Group 1 included patients with coronary lesions located on a vessel with a reference diameter above 3 mm (n = 24) and Group 2 included patients with a coronary lesion located on a vessel with a reference diameter below 3 mm (n = 7). (
  • Since a vessel flow depends on its diameter to fourth power, diameters are the logical candidates to guide vascular reconstructions to achieve realistic flows. (
  • Here, a diameter assignment method was developed where each vessel diameter was determined depending on its downstream tree size, aimed to reduce flow dispersion to within measured range. (
  • Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. (
  • Coronary endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilating and vasoconstricting factors and coronary vasoconstriction in response to the endothelium-dependent vasodilator acetylcholine. (
  • Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations. (
  • VEGF-B (vascular endothelial progress issue) belongs to a household of progress elements that regulate the formation of blood- and lymphatic vessels. (
  • We further discuss the cell origins of coronary endothelial cells and perivascular cells and summarize the critical signaling pathways regulating coronary vessel development. (
  • GHbA1C and Lp-PLA2 were strong independent predictors of plaque burden and FP and NC area at the minimum lumen lesion in patients with single-vessel and intermediate coronary lesions. (
  • The target vessel containing the culprit lesion was identified by angiography. (
  • Thirty-one patients who underwent Multislice 64 CT assessment of coronary lesions and stent implantation at the level of the significant coronary lesion were included in the study. (
  • By embryonic day 11.5-14.5, Raldh2 −/− hearts exhibited reduced venticular compact layer outgrowth and altered coronary vessel development. (
  • RESULTS: Microscopic analysis of high resolution autoradiographic images revealed a similar pattern of [3H]-5-HT binding in epicardial coronary and internal mammary artery, where it. (
  • CONCLUSIONS: The distribution of the [3H]-5-HT binding is different in the saphenous vein compared to epicardial coronary and internal mammary artery. (
  • All patients underwent coronary angiography on the first day after admission and patients with a greater than or equal to 80% obstruction in at least one epicardial coronary artery were included in the study. (
  • Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes occlusion (stoppage) or near-occlusion of the vessel. (
  • The origin of the left main coronary artery from the right sinus of Valsalva is related to some events, such as syncope, arrhythmias, angina, among others. (
  • It is also known as the left main coronary artery (abbreviated LMCA) and the left main stem coronary artery (abbreviated LMS). (
  • Methods and Results: The present prospective study involved 46 patients with first-episode acute coronary syndrome (ACS) who underwent optical coherence tomography in the non-culprit vessel. (
  • We aimed to evaluate the association of MPV with presence of coronary collateral vessel (CCV) in patients with ACS. (
  • Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study. (
  • Epicardial adipose tissue is related to coronary collateral vessel formation in patients with acute coronary syndrome. (
  • Increased red cell distribution width level is associated with absence of coronary collateral vessels in patients with acute coronary syndromes. (
  • Impaired coronary collateral vessel development in patients with metabolic syndrome. (
  • Mean platelet volume: an important predictor of coronary collateral development. (
  • Formation of extensive collateral vessels after chronic constriction of a coronary artery in dogs can provide for similar increases in blood flow to native and collateralized regions of myocardium during exertion. (
  • Conclusions -In vivo free-breathing coronary vessel wall and plaque imaging with MR has been successfully implemented in humans. (
  • 6 A noninvasive technique that would allow for visualization of plaque area and luminal vessel area narrowing and that also allowed for characterization of the plaque constituents would therefore be of great interest. (
  • This study will use standard IVUS imaging and OFDI to examine vulnerable plaques within blood vessels of the heart and to evaluate any changes that occur over time in heart blood vessels and plaque. (
  • Not only can we see if there are areas of narrowing in the coronary blood vessels , but we can also see areas of plaque build-up that may not yet be causing narrowing, but might nonetheless benefit from preventative treatments. (
  • there is already evidence of cholesterol plaque formation in their coronary blood vessels due to their high saturated fat diets and lack of regular exercise. (
  • Adequately virtualizing the coronary lumen plays a crucial role for simulating blood ow by means of fluid dynamics while additionally identifying the outer vessel wall in the case of arteriosclerosis is a prerequisite for further plaque compartment analysis. (
  • However, an excimer laser, which can vaporize thrombus, suppress platelet aggregation, and ablate the underlying plaque, has recently been shown to be effective in patients with acute coronary syndrome (ACS) [ 5 ]. (
  • Objectives: This study sought to explore the association between the Framingham Risk Score (FRS) and coronary plaque characteristics assessed by optical coherence tomography (OCT) imaging. (
  • The present study determined the relationship between GV and coronary plaque vulnerability in the non-culprit vessel. (
  • First, I want to talk about the function of blood vessels. (
  • of blood vessels, the architecture of the blood vessels and the histology. (
  • Now we saw that the blood vessel contain a lot of muscle cells. (
  • Imaging devices operating within blood vessels can provide higher resolution images than devices used from outside the body because they can operate at higher frequencies. (
  • But operating inside blood vessels requires devices that are small and flexible enough to travel through the circulatory system. (
  • A bypass system for bypassing a restriction in a parent vessel of a mammal to provide blood flow past the restriction. (
  • The bypass system couples a restricted artery to a venous vessel distal of a restriction to provide blood flow through the artery distal of the restriction. (
  • Blood flow is provided to a distal portion of the artery through an adjacent venous vessel so that blood can be provided to distal portions of the restricted artery. (
  • The blood-vessel wall is a complicated structure," says Elazer Edelman, director of the Harvard-MIT Biomedical Engineering Center and cofounder of Pervasis. (
  • 8 9 T2-weighted black-blood fast spin-echo (TSE) techniques have been successfully applied for aortic 10 and carotid 11 vessel wall imaging. (
  • However, signal from slow-flowing blood in the laminar boundary layer adjacent to the vessel wall may mimic vessel wall signal and cause an overestimation of wall thickness/area. (
  • Endothelium-dependent coronary blood flow reserve to acetylcholine (10(-6) to 10(-4) mol/L) was assessed at baseline and after 6 months of therapy. (
  • The most commonly used imaging device, an intravenous ultrasound (IVUS) catheter, is threaded through the blood vessels and uses sound waves to take pictures. (
  • An OFDI is a new type of catheter that takes more detailed pictures of blood vessel walls and plaques. (
  • At a baseline study visit, participants will first undergo an angiography procedure, in which x-ray pictures will be taken of the heart blood vessels. (
  • The Heart *Pumps 1,000 gallons of blood daily*Beats 100,ooo times daily*Transports blood 60,000 miles through a network of blood vessels* Located in the chest cavity in a region called mediastinum, 2/3 of the heart lies left of the midline*wider base lies superior & beneath 2nd rib, Apex lies inferior slightly to left btw. (
  • The study also reveals that the exact cause of the condition is not known yet but experts claim that "surging stress hormones (for example, adrenaline) essentially 'stun' the heart, triggering changes in heart muscle cells or coronary blood vessels (or both) that prevent the left ventricle from contracting effectively. (
  • 5,6 The exact cause is not known but some experts propose a sudden surge of catecholamines which stun the heart and trigger changes in myocardium or coronary blood vessels , or both, thus preventing the left ventricle from contracting effectively. (
  • Each volunteer had his or her heart rate and blood pressure measured at rest, as well as coronary vascular conductance, a Doppler ultrasound measure of blood flow through the coronary blood vessels of the heart. (
  • Angina is treated with drugs that widen the coronary blood vessels and reduce the heart's consumption of oxygen during stress and exercise. (
  • first suggested that isoflurane induces coronary vasodilation and, under appropriate circumstances, causes redistribution of myocardial blood flow contributing to development of regional myocardial ischemia. (
  • Although dual-inversion-recovery [ 2 ] (DIR) is the gold standard for vessel wall imaging, optimal lumen-vessel wall contrast is sometimes difficult to obtain and the time-window available for imaging is limited due to the competing requirements between TI* (blood signal nulling time) and TD (period of minimal myocardial motion). (
  • This work extends PS-IR to PS-DIR and combined with spiral-imaging, multi-slice black-blood coronary vessel wall imaging is enabled in a single breath-hold. (
  • To develop, and test a phase-sensitive DIR (PS-DIR) single-breath-hold multi-slice spiral black-blood coronary vessel wall imaging method. (
  • Consequently, single-breath-hold multi-slice black-blood coronary vessel wall imaging is enabled using PS-DIR. (
  • What is the function of the heart and blood vessels? (
  • Heart -your heart is to pump blood into the blood vessels. (
  • The function of the coronary blood vessels? (
  • The coronary blood vessels supply blood (oxygen and nutrients to the heart. (
  • coronary blood vessel supplies blood to the heart and drains blood from the heart. (
  • When valves in the heart or blood vessels fail to function? (
  • Heart blood vessels is what collects blood and pumps it to the lower chamber. (
  • What are the parts of the blood vessels and its function? (
  • What is the function of the blood vessels on the outer wall of the heart? (
  • So the blood vessels on the outside have that job. (
  • Blood vessels that lead from the heart that are high in oxygen and nutrients have their first branch off the aorta that goes to these blood vessels. (
  • Can the heart function without the blood and blood vessels? (
  • Blood vessels are required to transport blood. (
  • The heart is the pump, the blood is the product carrying oxygen and the vessels are the network to all points of the body. (
  • Blood vessels are the passageway of blood. (
  • When any blood vessel is punctured or cut,blood flows out.There are three kinds of blood vessels in the human body. (
  • Their thick walls withstand the force of blood from the heart.Blood vessels are an integral part of the circulatory system. (
  • They are small blood vessels that take deoxygenated blood to the heart. (
  • How is the structure of blood vessels related to their function? (
  • Which vessels move blood to the heart? (
  • What blood vessels return blood to the heart? (
  • The blood vessels that return blood to the heart are called Veins. (
  • The cardiovascular system consists of the heart, blood and blood vessels. (
  • What vessels take blood from the heart? (
  • The cardiovascular (from Latin words meaning "heart" and "vessel") system comprises the blood, heart, and blood vessels . (
  • [3] The lymph, lymph nodes , and lymph vessels form the lymphatic system, which returns filtered blood plasma from the interstitial fluid (between cells) as lymph. (
  • The essential components of the human cardiovascular system are the heart , blood and blood vessels . (
  • The cardiovascular systems of humans are closed, meaning that the blood never leaves the network of blood vessels . (
  • In contrast, oxygen and nutrients diffuse across the blood vessel layers and enter interstitial fluid , which carries oxygen and nutrients to the target cells, and carbon dioxide and wastes in the opposite direction. (
  • Angiogenesis is the process of growing new blood vessels. (
  • During the surgery, a small part of a blood vessel is taken from another area of the body, usually a vein from the leg, and surgically attached across an area of severe narrowing or blockage, thus bypassing the problem area. (
  • The blood is rerouted through the healthy vessel, and blood flow is restored to the heart muscle. (
  • The coronary network supplies oxygen-carrying blood to each myocyte in the myocardium to meet its metabolic demand. (
  • Coronary vessels that nourish the guts develop from three major sources, the endocardium on the inside floor of the hearts blood-filled chambers being one of many main contributors. (
  • In regular circumstances, the grownup coronary heart can not generate new blood vessels from the endocardium, as a result of the endocardium-to-coronary vessel transition is blocked by a connective tissue wall beneath the endocardium. (
  • In regular circumstances, blood nourishes the grownup coronary heart by coronary vessels. (
  • The most important coronary vessels are positioned on the guts floor, and their branches dive into coronary heart muscle to ship oxygen-rich blood into the inside components of the guts. (
  • Nonetheless, any remaining blood clots within the small coronary vessels inside the guts can't be eliminated, which might result in native infarction of the guts muscle. (
  • In an acute coronary syndrome, sudden blockage in a coronary artery greatly reduces or cuts off the blood supply to an area of the heart muscle (myocardium). (
  • Calcium channel blockers prevent blood vessels from narrowing (constricting) and can counter coronary artery spasm. (
  • When taken regularly, hawthorn can dilate coronary blood vessels, help blood flow. (
  • A description is given of a device and a method for reconstructing the three-dimensional structure of blood vessels or other structures. (
  • reconstructing the three-dimensional image of the blood vessel from said cross-sectional dimensions and said center line. (
  • The left coronary artery (abbreviated LCA) is an artery that arises from the aorta above the left cusp of the aortic valve and feeds blood to the left side of the heart. (
  • The results are also encouraging in patients with very small vessels. (
  • Although about 250 cases of SCAD have been reported in the literature, to the best of our knowledge, spontaneous three vessel coronary dissection associated with typical effort angina has never been reported. (
  • One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups. (
  • Lipid-rich plaques with thin fibrous caps are often associated with acute coronary events, not only because of their greater vulnerability to rupture, but also because of enhanced thrombogenicity after rupture. (
  • Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? (
  • Lp-PLA2, diabetes and NC area were significant predictors of acute coronary lesions, and the predictive value of Lp-PLA2 was confirmed by the finding of a high area-under-the-curve in a ROC analysis (0.837, 95% CI:0.778-0.895, P = 0.000), as well as by the reasonable sensitivity and specificity of cut-off values. (
  • Furthermore, Lp-PLA2 has a certain predictive value for acute coronary lesions. (
  • In my opinion, I think that this case may be a sugammadex hypersensitivity event, similar to Kounis syndrome, rather than acute coronary syndrome, as the authors had described [ 2 ]. (
  • Kounis syndrome is defined as the concurrence of acute coronary syndromes with conditions associated with mast cell and platelet activation, which involves inflammatory cells in the setting of allergic reactions or hypersensitivity, and anaphylactic or anaphylactoid insults. (
  • High levels of serum uric acid impair development of coronary collaterals in patients with acute coronary syndrome. (