The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The circulation of blood through the CORONARY VESSELS of the HEART.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Narrowing or constriction of a coronary artery.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The hollow, muscular organ that maintains the circulation of the blood.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Spasm of the large- or medium-sized coronary arteries.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Drugs used to cause dilation of the blood vessels.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Nutrient blood vessels which supply the walls of large arteries or veins.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Elements of limited time intervals, contributing to particular results or situations.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Pathologic deposition of calcium salts in tissues.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The vessels carrying blood away from the heart.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
The blood vessels which supply and drain the RETINA.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The nonstriated involuntary muscle tissue of blood vessels.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Substances used to allow enhanced visualization of tissues.
Treatment process involving the injection of fluid into an organ or tissue.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The flow of BLOOD through or around an organ or region of the body.
The vessels carrying blood away from the capillary beds.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Contractile activity of the MYOCARDIUM.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Pressure, burning, or numbness in the chest.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Lesions formed within the walls of ARTERIES.
The physiological renewal, repair, or replacement of tissue.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The return of a sign, symptom, or disease after a remission.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The smallest divisions of the arteries located between the muscular arteries and the capillaries.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The vein which drains the foot and leg.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
Formation and development of a thrombus or blood clot in the blood vessel.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Motion pictures of the passage of contrast medium through blood vessels.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The main trunk of the systemic arteries.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Obstruction of flow in biological or prosthetic vascular grafts.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
The degree to which BLOOD VESSELS are not blocked or obstructed.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Disease having a short and relatively severe course.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The minute vessels that connect the arterioles and venules.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Drugs used to cause constriction of the blood vessels.
A characteristic symptom complex.
The main artery of the thigh, a continuation of the external iliac artery.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Bleeding or escape of blood from a vessel.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Pathological conditions involving the HEART including its structural and functional abnormalities.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).

Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures. (1/8389)

We studied phasic right coronary blood flow in well trained normal dogs and dogs with pulmonic stenosis. We installed electromagnetic flow transducers and pressure tubes under anesthesia to monitor right coronary blood flow, cardiac output, central aortic blood pressure, and right ventribular pressure. In normotensive dogs, systolic flow amplitude equaled early diastolic flow levels. The ratio of systolic to diastolic flow at rest was substantially greater in the right coronary bed (36+/-1.3%) than in the left circumflex bed (13+/-3.6%). Right diastolid flow runoff, including the cove late in diastole, resembled left circumflex runoff. Blood flow to the normotensive right (37+/-1.1 ml/min 100(-1) g) and the left (35+/-1.0 ml/min(-1) g) ventricular myocardium indicated equal perfusion of both cardiac walls. Throttling of systolic flow was related directly to the right ventricular systolic pressure level in the dogs with pulmonic stenosis. Retrograde systolic flow occurred in severe right ventricular hypertension. The late diastolic runoff pattern in dogs with pulmonic stenosis appeared the same as for the normotensive dogs. We obtained systolic to diastolic flow ratios of 1/3 the value of normotensive hearts in high and severe pulmonic hypertension. Electrocardiograms and studies of pathology suggested restricted blood flow to the inner layers of the right myocardium in the dogs with severe and high right ventricular hypertension. Normotensive and hypertensive peak hyperemic flow responses were similar, except for an increased magnitude of diastolic flow, with proportionately less systolic flow in hypertensive states.  (+info)

The effect of cardiac contraction on collateral resistance in the canine heart. (2/8389)

We determined whether the coronary collateral vessels develop an increased resistance to blood flow during systole as does the cognate vascular bed. Collateral resistance was estimated by measuring retrograde flow rate from a distal branch of the left anterior descending coronary artery while the main left coronary artery was perfused at a constant pressure. Retrograde flow rate was measured before and during vagal arrest. We found that in 10 dogs the prolonged diastole experienced when the heart was stopped caused no significant change in the retrograde flow rate, which indicated that systole has little effect on the collateral resistance. However, when left ventricular end-diastolic pressure was altered by changing afterload or contractility, a direct relationship between end-diastolic pressure and collateral resistance was noted.  (+info)

Variations in 35SO4 incorporation into glycosaminoglycans along canine coronary arteries. A possible index of artery wall stress. (3/8389)

Focal areas of accentuated wall stress along the course of canine coronary arteries may be revealed by the level of 35SO4 incorporation into glycosaminoglycans (GAG). In the anterior descending artery, 35SO4 incorporation in higher in the proximal than in the distal region and may be extraordinarily high as the vessel enters a proximally located muscle bridge and at the takeoff region of multidirectional branches. In the circumflex artery, the incorporation also is higher in the proximal than in the distal region and is high at the genu where the posterior descending artery forms. There are differences in uptake of 35SO4 in vessels even when the arteries arise from the same vascular bed.this was shown by the higher incorporation in the left coronary artery than in the right coronary artery. A general anatomical agreement exists between these sites of high 35SO4 incorporation and previously described locations of interval elastic disruption ans proliferation of intimal connective tissue in the dog.  (+info)

Site of myocardial infarction. A determinant of the cardiovascular changes induced in the cat by coronary occlusion. (4/8389)

The influence of site of acute myocardial infarction on heart rate, blood pressure, cardiac output, total peripheral resistance (TPR), cardiac rhythm, and mortality was determined in 58 anesthetized cats by occlusion of either the left anterior descending (LAD), left circumflex or right coronary artery. LAD occlusion resulted in immediate decrease in cardiac output, heart rate, and blood pressure, an increase in TPR, and cardiac rhythm changes including premature ventricular beats, ventricular tachycardia, and occasionally ventricular fibrillation. The decrease in cardiac output and increase in TPR persisted in the cats surviving a ventricular arrhythmia. In contrast, right coronary occlusion resulted in a considerably smaller decrease in cardiac output. TPR did not increase, atrioventricular condition disturbances were common, and sinus bradycardia and hypotension persisted in the cats recovering from an arrhythmia. Left circumflex ligation resulted in cardiovascular changes intermediate between those produced by occlusion of the LAD or the right coronary artery. Mortality was similar in each of the three groups. We studied the coronary artery anatomy in 12 cats. In 10, the blood supply to the sinus node was from the right coronary artery and in 2, from the left circumflex coronary artery. The atrioventricular node artery arose from the right in 9 cats, and from the left circumflex in 3. The right coronary artery was dominant in 9 cats and the left in 3. In conclusion, the site of experimental coronary occlusion in cats is a major determinant of the hemodynamic and cardiac rhythm changes occurring after acute myocardial infarction. The cardiovascular responses evoked by ligation are related in part to the anatomical distribution of the occluded artery.  (+info)

Inhibition of endothelium-dependent hyperpolarization by endothelial prostanoids in guinea-pig coronary artery. (5/8389)

1. In smooth muscle of the circumflex coronary artery of guinea-pig, acetylcholine (ACh, 10(-6) M) produced an endothelium-dependent hyperpolarization consisting of two components. An initial component that occurs in the presence of ACh and a slow component that developed after ACh had been withdrawn. Each component of the hyperpolarization was accompanied by an increase in membrane conductance. 2. Indomethacin (5 x 10(-6) M) or diclofenac (10(-6) M), both inhibitors of cyclooxygenase, abolished only the slow hyperpolarization. The initial hyperpolarization was not inhibited by diclofenac nor by nitroarginine, an inhibitor of nitric oxide synthase. 3. Both components of the ACh-induced hyperpolarization were abolished in the presence of atropine (10(-6) M) or high-K solution ([K+]0 = 29.4 mM). 4. The interval between ACh-stimulation required to generate an initial hyperpolarization of reproducible amplitude was 20 min or greater, but it was reduced to less than 5 min after inhibiting cyclooxygenase activity. Conditioning stimulation of the artery with substance P (10(-7) M) also caused a long duration (about 20 min) inhibition of the ACh-response. 5. The amplitude of the hyperpolarization generated by Y-26763, a K+-channel opener, was reproducible within 10 min after withdrawal of ACh. 6. Exogenously applied prostacyclin (PGI2) hyperpolarized the membrane and reduced membrane resistance in concentrations over 2.8 x 10(-9)M. 7. At concentrations below threshold for hyperpolarization and when no alteration of membrane resistance occurred, PGI2 inhibited the initial component of the ACh-induced hyperpolarization. 8. It is concluded that endothelial prostanoids, possibly PGI2, have an inhibitory action on the release of endothelium-derived hyperpolarizing factor.  (+info)

A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig. (6/8389)

1. The purpose of this study was to compare the pharmacological properties (i.e. the AV nodal depressant, vasodilator, and inotropic effects) of two AV nodal blocking agents belonging to different drug classes; a novel A1 adenosine receptor (A1 receptor) agonist, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside (CVT-510), and the prototypical calcium channel blocker diltiazem. 2. In the atrial-paced isolated heart, CVT-510 was approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50 = 41 nM) than to increase coronary conductance (EC50 = 200 nM). At concentrations of CVT-510 (40 nM) and diltiazem (1 microM) that caused equal prolongation of S-H interval (approximately 10 ms), diltiazem, but not CVT-510, significantly reduced left ventricular developed pressure (LVP) and markedly increased coronary conductance. CVT-510 shortened atrial (EC50 = 73 nM) but not the ventricular monophasic action potentials (MAP). 3. In atrial-paced anaesthetized guinea-pigs, intravenous infusions of CVT-510 and diltiazem caused nearly equal prolongations of P-R interval. However, diltiazem, but not CVT-510, significantly reduced mean arterial blood pressure. 4. Both CVT-510 and diltiazem prolonged S-H interval, i.e., slowed AV nodal conduction. However, the A1 receptor-selective agonist CVT-510 did so without causing the negative inotropic, vasodilator, and hypotensive effects associated with diltiazem. Because CVT-510 did not affect the ventricular action potential, it is unlikely that this agonist will have a proarrythmic action in ventricular myocardium.  (+info)

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice. (7/8389)

1. Isometric tension was recorded in isolated rings of aorta, carotid, coronary and mesenteric arteries taken from endothelial nitric oxide synthase knockout mice (eNOS(-/-) mice) and the corresponding wild-type strain (eNOS(+/+) mice). The membrane potential of smooth muscle cells was measured in coronary arteries with intracellular microelectrodes. 2. In the isolated aorta, carotid and coronary arteries from the eNOS(+/+) mice, acetylcholine induced an endothelium-dependent relaxation which was inhibited by N(omega)-L-nitro-arginine. In contrast, in the mesenteric arteries, the inhibition of the cholinergic relaxation required the combination of N(omega)-L-nitro-arginine and indomethacin. 3. The isolated aorta, carotid and coronary arteries from the eNOS(-/-) mice did not relax in response to acetylcholine. However, acetylcholine produced an indomethacin-sensitive relaxation in the mesenteric artery from eNOS(-/-) mice. 4. The resting membrane potential of smooth muscle cells from isolated coronary arteries was significantly less negative in the eNOS(-/-) mice (-64.8 +/- 1.8 mV, n = 20 and -58.4 +/- 1.9 mV, n = 17, for eNOS(+/+) and eNOS(-/-) mice, respectively). In both strains, acetylcholine, bradykinin and substance P did not induce endothelium-dependent hyperpolarizations whereas cromakalim consistently produced hyperpolarizations (- 7.9 +/- 1.1 mV, n = 8 and -13.8 +/- 2.6 mV, n = 4, for eNOS(+/+) and eNOS(-/-) mice, respectively). 5. These findings demonstrate that in the blood vessels studied: (1) in the eNOS(+/+) mice, the endothelium-dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo-oxygenase but not EDHF; (2) in the eNOS(-/-) mice, NO-dependent responses and EDHF-like responses were not observed. In the mesenteric arteries acetylcholine releases a cyclo-oxygenase derivative.  (+info)

In-stent neointimal proliferation correlates with the amount of residual plaque burden outside the stent: an intravascular ultrasound study. (8/8389)

BACKGROUND: The aim of this study was to evaluate the relationship between residual plaque burden after coronary stent implantation and the development of late in-stent neointimal proliferation. METHODS AND RESULTS: Between January 1996 and May 1997, 50 patients underwent intravascular ultrasound (IVUS) interrogation at 6+/-1.2 months after coronary stent implantation in native coronary arteries. IVUS images were acquired with a motorized pullback, and cross-sectional measurements were performed within the stents at 1-mm intervals. The following measurements were obtained: (1) lumen area (LA), (2) stent area (SA), (3) area delimited by the external elastic membrane (EEMA), (4) percent neointimal area calculated as (SA-LA/SA)x100, and (5) percent residual plaque area calculated as (EEMA-SA)/EEMAx100. Volume measurements within the stented segments were calculated by applying Simpson's rule. In the pooled data analysis of 876 cross sections, linear regression showed a significant positive correlation between percent residual plaque area and percent neointimal area (r=0.50, y= 45.03+0.29x, P<0.01). There was significant incremental increase in mean percent neointimal area for stepwise increase in percent residual plaque area. Mean percent neointimal area was 16.3+/-10.3% for lesions with a percent residual plaque area of <50% and 27.7+/-11% for lesions with a percent residual plaque area of >/=50% (P<0.001). The volumetric analysis showed that the percent residual plaque volume was significantly greater in restenotic lesions compared with nonrestenotic lesions (58.7+/-4.3% versus 51.4+/-5.7%, respectively; P<0.01). CONCLUSIONS: Late in-stent neointimal proliferation has a direct correlation with the amount of residual plaque burden after coronary stent implantation, supporting the hypothesis that plaque removal before stent implantation may reduce restenosis.  (+info)

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These results show for the first time that the presence of atherosclerosis in human coronary arteries specifically augments contractions to cysteinyl leukotrienes and provides an enzymatic capacity within the vessel wall in the form of infiltrating macrophages and possibly smooth muscle cells to produce leukotrienes that could contribute to the hyperreactivity of atherosclerotic vessels. Hyperreactivity of human atherosclerotic coronary arteries to LTC4 and LTD4 was unaffected by endothelium-derived mediators. Previous reports29 have shown increased responsiveness of atherosclerotic arteries to serotonin that was unaffected by the endothelium. In those studies, hyperreactivity was reported to involve an increased responsiveness of the receptor or signal transduction system that was not apparent in the receptors present in the nondiseased arteries. Our present findings provide no evidence of cysteinyl leukotriene receptors in nonatherosclerotic epicardial coronary arteries, as suggested by the ...
Objective To visualize epicardial and intramyocardial coronary blood flow by using a noninvasive echocardiography system.. Methods In five juvenile swines, coronary flow imaging was used to visualize the different segments of epicardial coronary and intramyocardial arteries. Pulsed-Doppler spectrums were recorded and analyzed. The left anterior descending artery (LAD) and intramyocardial coronary blood flow signals were recorded at baseline and during dipyridamole administration.. Results Epicardial and intramyocardial coronary arteries could be visualized by coronary flow imaging. The systolic component of coronary flow in the right coronary artery (RCA) was greater than in the LAD. The intramyocardial blood flow was characterized by persistent retrograde blood flow velocity during systole. Vasodilation with dipyridamole produced exaggerated differences in the phasic pattern of coronary blood flow in epicardial and intramyocardial vessels.. Conclusion Color Doppler coronary flow imaging ...
The present study showed that ET-1 at small and physiological concentrations (10−11 mol/L) caused significant contraction in coronary smooth muscle cells with no detectable increases in [Ca2+]i. Although some studies have shown that picomolar concentrations of ET-1 increase [Ca2+]i in cultured human coronary smooth muscle cells,42 the present data are consistent with previous reports that these small ET-1 concentrations do not significantly increase [Ca2+]i in freshly isolated porcine coronary smooth muscle cells.32 The difference in the results could be related to differences in the cell preparation or the species studied. We should note that in the present study, [Ca2+]i was measured in an area of homogeneous fluorescence 1 μm in diameter, 1 μm from the plasma membrane, and 1 μm from the nucleus. Although small concentrations of ET-1 did not cause any detectable increases in [Ca2+]i in this representative part of the cell, small concentrations of PGF2α significantly increased [Ca2+]i in ...
B129 Mouse Coronary Artery Endothelial Cells from Creative Bioarray are isolated from coronary artery of pathogen-free laboratory B129S2/SvPasCrl mice. B129 Mouse Coronary Artery Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with PECAM-1 antibody, following the application of magnetic pre-coated with secondary antibody ...
Studies in animals with normal coronary arteries have shown that coronary flow reserve can be predicted by angiographic measurements of arterial stenosis. Studies in man, however, suggest that even quantitative analysis of coronary angiograms cannot predict the physiologic significance of individual coronary lesions. These studies, however, were carried out in patients with either widespread, diffuse coronary artery disease or by measurement techniques that tend to underestimate maximal coronary flow reserve. To determine the relationship between coronary arterial stenosis and coronary flow reserve (CFR) in patients with discrete limited coronary atherosclerosis, we studied 50 patients with a single discrete coronary stenosis in only one or two vessels. The minimum coronary arterial cross-sectional area (mCSA), percent area stenosis (%AS), and percent diameter stenosis in the left and right anterior oblique projections were determined by the Brown/Dodge method of quantitative coronary ...
OBJECTIVE--To assess whether the extent of LDL oxidation influences its cytotoxic effects, thus contributing to its atherogenic potential. DESIGN AND SETTING--The effects of native and modified LDL on cultured human coronary artery smooth muscle cells (SMC) and endothelial cells (ECs) were investigated. MAIN OUTCOME MEASURES--Four indices of cytotoxicity were studied: (i) chromium-51 release; (ii) 5-bromo-2-deoxyuridine (BrDUrd) uptake; (iii) morphological appearance; and (iv) EC migration. RESULTS--(i) Minimally modified (mm) LDL (400 micrograms/ml) causes significant 51Cr release; the cytotoxic effect was significantly greater for copper oxidised (ox) LDL (400 micrograms/ml). Native LDL had no effect. (ii) BrDUrd uptake studies showed significant inhibition of cell proliferation by 100 micrograms/ml of oxLDL and to a lesser extent by mmLDL; native LDL had no effect. (iii) Morphological appearance was not altered by native LDL. Changes in cell morphology were induced by mmLDL (400 ...
Several limitations of the present study must be considered. 1) Angiographically normal patients were included in the present study. Recently developed intravascular ultrasound has been reported [33]to demonstrate intimal thickening with a three-layered appearance in the normal coronary artery in vitro. Localized atherosclerotic lesions have been confirmed in angiographically minimally diseased coronary arteries by intravascular ultrasound in patients with focal vasospasm [34]. Diffuse concentric thickening of the coronary vessel wall might be demonstrated by intravascular ultrasound in patients with diabetes mellitus or diabetic retinopathy because in the present study, coronary diameters were significantly smaller in diabetic patients than in control patients, and minimally diseased coronary arteries ,25% were demonstrated by angiography in the left circumflex or right coronary artery in 5 patients. Such differences would be resolved by intravascular ultrasound. 2) Reduced coronary flow ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
TY - JOUR. T1 - Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. AU - Keyes, Joseph T.. AU - Lockwood, Danielle R.. AU - Simon, Bruce R.. AU - Geest, Jonathan P.Vande. PY - 2013/1. Y1 - 2013/1. N2 - Objective: Understanding coronary artery mass transport allows researchers to better comprehend how drugs or proteins move through, and deposit into, the arterial wall. Characterizing how the convective component of transport changes based on arterial location could be useful to better understand how molecules distribute in different locations in the coronary vasculature. Methods and results: We measured the mechanical properties and wall fluid flux transport properties of de-endothelialized (similar to post-stenting or angioplasty) left anterior descending (LADC) and right (RC) porcine coronary arteries along their arterial lengths. Multiphoton microscopy was used to determine microstructural differences. Proximal LADC ...
TY - JOUR. T1 - Protective effects of an indenoindole antioxidant on coronary endothelial function after long-term storage. AU - Wiklund, L.. AU - Miller, Virginia M. AU - McGregor, C. G A. AU - Sjoquist, P. O.. AU - Berggren, H.. AU - Nilsson, F.. PY - 1995. Y1 - 1995. N2 - Experiments were designed to evaluate function of the endothelium and smooth muscle of coronary arteries following storage of hearts in cardioplegia containing an inhibitor of lipid peroxidation (H 290/51, cis-7- metyl-9-methoxy-5,5a, 6,10b tetrahydroindeno [2,1-b] indole). Canine hearts were perfused with crystalloid cardioplegia (Plegisol, 15 ml/kg, 4°C) and left circumflex arteries were isolated and studied either immediately (group I, n=6), or after storage of the hearts at 4°C for 10 (group II, n=6) or 24 hr with (group III, n=6) or without (group IV, n=6) addition of H 290/51. The final concentration of H 290/51 was 1 μmol/L. Arteries were removed, cut into rings, and suspended in organ chambers for measurements of ...
Compared with the normal coronary arteries, significant alpha-adrenergic constriction of the stenotic coronary arteries can be induced by cardiac sympathetic nerve stimulation, resulting in the precipitation of myocardial ischemia with regional wall-motion abnormalities and net lactate production (26). In an experimental model, post-stenotic coronary vasoconstriction that was prevented by intravenous phentolamine or selective alpha2-blockade with rauwolscine in the absence as well as in the presence of acute beta-blockade was observed (26).. Under clinical conditions, sympathetic nerve activation may be induced by isometric as well as dynamic exercise, which may be involved in the narrowing of stenotic coronary arteries (4,5). This narrowing of the epicardial coronary segments can be prevented by administration of intracoronary nitroglycerin or the calcium-antagonist diltiazem, probably owing to the direct vasodilating properties of these two agents.. The precise mechanism responsible for ...
Definition of Circumflex coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Circumflex coronary artery? Meaning of Circumflex coronary artery as a legal term. What does Circumflex coronary artery mean in law?
TY - JOUR. T1 - Enhancement of potassium induced relaxation of isolated coronary artery smooth muscle by adenosine. AU - Foley, D. H.. AU - Mason, D. T.. AU - Amsterdam, Ezra A. PY - 1975. Y1 - 1975. N2 - Local regulation of coronary blood flow may involve an interplay of the vasoactive properties of several metabolic factors. To evaluate the effect of adenosine (Ado) on K+ induced relaxation of vascular smooth muscle, helical strips of cat coronary arteries, suspended in an organ bath of Krebs solution (37° C, 95% O2 and 5% CO2), were studied during isometric contraction stimulated by acetylcholine (ACh). From a baseline concentration of 3.0 mM, a small increment in [K+] of 2 mM induced a 16.0 ± 2.7% relaxation of tension from the initial level. However, in the presence of Ado, which induced a 20.4 ± 3.0% relaxation of 29.7 ± 4.6%. The latter was significantly greater (P , 0.005) than the response in the absence of Ado. Similarly, a 4 mM [K+] increment elicited a 14.9 ± 3.0% relaxation ...
Recent evidence suggests that higher restenosis rate is observed after coronary angioplasty of an infarct-related artery. Furthermore, angiographic restenosis seems associated with a deterioration of left ventricular function at follow-up. The aim of this study was to assess the acute results and angiographic restenosis following coronary artery stenting of infarct-related (Group 1) and non infarct-related coronary arteries (Group 2). We retrospectively analyzed the results of 381 consecutive patients treated with Palmaz-Schatz coronary stent implantation between May 1992 and January 1996. Stenting of the infarct-related artery was performed in 154 patients (Group 1), while 227 patients (Group 2) received stenting of the non infarct-related artery. Both groups had similar age, gender, clinical conditions and coronary angiographic pattern. There were no significant differences between groups, concerning type of stented coronary vessel (left anterior descending-LAD 52.4% vs non-LAD 47.6%, Group 1, ...
Olivey H.E., Svensson E.C.. The establishment of the coronary circulation is critical for the development of the embryonic heart. Over the last several years, there has been tremendous progress in elucidating the pathways that control coronary development. Interestingly, many of the pathways that regulate the development of the coronary vasculature are distinct from those governing vasculogenesis in the rest of the embryo. It is becoming increasingly clear that coronary development depends on a complex communication between the epicardium, the subepicardial mesenchyme, and the myocardium mediated in part by secreted growth factors. This communication coordinates the growth of the myocardium with the formation of the coronary vasculature. This review summarizes our present understanding of the role of these growth factors in the regulation of coronary development. Continued progress in this field holds the potential to lead to novel therapeutics for the treatment of patients with coronary artery ...
TY - JOUR. T1 - Association of remodeling with endothelial shear stress, plaque elasticity, and volume in coronary arteries. T2 - A pilot coronary computed tomography angiography study. AU - Katranas, Sotirios A.. AU - Kelekis, Anastasios L.. AU - Antoniadis, Antonios P.. AU - Chatzizisis, Yiannis S.. AU - Giannoglou, George D.. PY - 2014/5. Y1 - 2014/5. N2 - We sought to noninvasively assess the relationship between arterial remodeling, endothelial shear stress (ESS), and wall stiffness in coronary arteries. We studied 28 coronary arteries from 22 patients undergoing coronary computed tomography angiography (CCTA). The ESS was calculated in 2-mm long segments using computational fluid dynamics. Local remodeling, plaque dimensions, and local wall stiffness were assessed in each segment. The ESS was lower in the regions of excessive expansive remodeling versus compensatory expansive versus inadequate expansive versus constrictive remodeling. Areas of decreased wall stiffness more frequently ...
TY - JOUR. T1 - In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. AU - Giannoglou, George D.. AU - Chatzizisis, Yiannis S.. AU - Sianos, George. AU - Tsikaderis, Dimitrios. AU - Matakos, Antonis. AU - Koutkias, Vassilios. AU - Diamantopoulos, Panagiotis. AU - Maglaveras, Nicos. AU - Parcharidis, George E.. AU - Louridas, George E.. PY - 2006/9. Y1 - 2006/9. N2 - OBJECTIVES: The in-vivo validation of geometrically correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane coronary angiography has not been adequately investigated. The purpose of this study was to describe the reconstruction method and investigate its in-vivo feasibility and accuracy. METHODS: In 17 coronary arteries (mean length, 85.7±17.1 mm) from nine patients, an intravascular ultrasound procedure along with a biplane coronary angiography was performed. ...
A coronary arterial fistula is a connection between 1 or more of the coronary arteries and a cardiac chamber or great vessel. This is a rare defect and usually occurs in isolation (1). We report a case of coronary arterial fistula with adjacent atherosclerotic plaque treated with a covered stent in a patient with non-ST-segment elevation myocardial infarction. This 59-year-old man had a medical history of type 2 diabetes mellitus and experienced severe chest tightness. A high serum troponin I level of 3.219 ng/ml was noted, and non-ST-segment elevation myocardial infarction was diagnosed. Coronary angiography showed 3 coronary arterial fistulae at the left main coronary artery proximal and mid left anterior descending coronary artery (Figure 1A). The stenotic lesion with haziness was noted at the mid left anterior descending coronary artery, and the biggest coronary arterial fistula stood aside (Figure 1B, Online Video 1). An intravascular ultrasound study showed severe stenosis with ...
Bovine Coronary Artery Endothelial Cells: BCAEC (Cryovial); find Sigma-Aldrich-B300-05 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
A number of studies have asserted that moderate drinking has a positive benefit on cardiovascular health. Now, scientists at the University of Rochester Medical Center have discovered how alcohol consumption can help to prevent heart disease. The research, published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, studied the effects of moderate amounts of alcohol in human coronary artery smooth muscle cells and in the carotid arteries of mice [1]. In both cases, regular, limited amounts of alcohol inhibited a protein called Notch 1 and prevented the buildup of smooth muscle cells in blood vessels that leads to the narrowing of the arteries and can put you at risk for a heart attack or stroke.. ...
Coronary artery disease: A major cause of illness and death, coronary artery disease (CAD) begins when hard cholesterol substances (plaques) are deposited within a coronary artery. (The coronary arteries arise from the aorta adjacent to the heart and supply the heart muscle with blood that is rich in oxygen. They are called the coronary arteries because they encircle the heart in the manner of a crown.) The plaques in the coronary arteries can cause a tiny clot to form which can obstruct the flow of blood to the heart muscle producing symptoms and signs of CAD that may include: Chest pain (angina pectoris) from inadequate blood flow to the heart; Heart attack (acute myocardial infarction), from the sudden total blockage of a coronary artery; or Sudden death, due to a fatal disturbance of the heart rhythm. Common Misspellings: coronary artery diease, coronary artery desease ...
TY - JOUR. T1 - Role of potassium channels in coronary vasodilation. AU - Dick, Gregory M.. AU - Tune, Johnathan D.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting membrane potential (Em) and serve as targets of endogenous and therapeutic vasodilators. Em in CASMC is in the voltage range for activation of L-type Ca2+ channels; therefore, when K+ channel activity changes, Ca2+ influx and arterial tone change. This is why both Ca2+ channel blockers and K+ channel openers have such profound effects on coronary blood flow; the former directly inhibits Ca2+ influx through L-type Ca2+ channels, while the latter indirectly inhibits Ca2+influx by hyperpolarizing Em and reducing Ca2+ channel activity. K+ channels in CASMC play important roles in vasodilation to endothelial, ischemic and metabolic stimuli. The purpose of this article is to review the types of K+ channels expressed in CASMC, discuss the regulation of their activity by ...
Abstract: Systematic quantitative investigations were performed in the coronary arteries of 102 hearts of 36 mammal species with an overall more than tenthousandfold difference of their heart weight. After postmortem coronary angiography with a filling pressure of 100 mm Hg x-rays were taken, and the widest diameters of the coronary artery stems were determined. We found a nearly linear correlation between diameter of a standardized coronary artery and virtual diameter of heart, but the increase in diameter of coronary arteries exceeded somewhat that of the diameter of heart especially for heart weights surmounting 100 g. Perhaps relative enlargement of coronary arteries in the bigger hearts contributes to the prevention of large increase of blood flow velocity.. Keywords: Coronary artery diameter, Heart weight, Coronary blood flow Authors: J. W. Thüroff, W. Hort and H. Lichti. Journal: Basic Research in Cardiology. ...
2016 International Federation for Medical and Biological Engineering The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress ...
Coronary artery calcium (CAC) 0; Coronary artery calcium (CAC) 1-399; Coronary artery calcium (CAC) >=400; Coronary flow reserve (CFR) >=2.0; Coronary flow reserve (CFR ...
Both the right and left coronary artery ostia arise from their respective aortic sinuses. Both ostia are located more than half the distance between the sinotubular junction and aortic valve annulus (Fig. 2-1). The left main coronary artery originates with an elliptic ostium measuring approximately 3.2 ± 1.1 mm × 4.7 ± 1.2 mm.2 This coronary artery continues at an acute angle and travels parallel to the aortic sinus wall, coursing between the pulmonary artery and the left atrium in the region of the left atrial appendage. The length of the left main artery ranges from 0 mm (double-barrel ostium) to 20 mm. However, in most cases, the length of the left main coronary artery is between 6 and 15 mm, with an average diameter ranging from 3 to 6 mm.3 In two-thirds of cases, the left main coronary artery bifurcates into the left anterior descending (LAD) and circumflex arteries (Fig. 2-2); in one-third of cases, it trifurcates into the LAD artery, the circumflex artery, and a ramus intermedius ...
1. The consequences of the reduced production of nitric oxide (NO) by cells from regenerated endothelium were investigated by measuring membrane potential of smooth muscle cells (SMCs), isometric tension and cyclic nucleotides content in porcine coronary arteries with intimal thickening, four weeks following angioplasty. 2. Under basal conditions, SMCs of coronary arteries with regenerated endothelium were depolarized by 10 mV. This depolarization was associated with 82% decreased level of cGMP without alteration in cAMP. 3. Sodium nitroprusside (SNP, 1 μM) repolarized SMCs of the previously denuded coronary arteries. This repolarization was abolished by 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10 μM) and not suppressed by glibenclamide (10 μM), iberiotoxin (IbTX, 100 nM) and the combination of charybdotoxin (ChTX, 40 nM) plus apamin (100 nM). 4. Four-aminopyridine (4-AP, 1-5 mM) generated spontaneous rhythmic activities only in coronary arteries with regenerated endothelium which ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
Normal Human HUVEC Primary, 10-Donor Pool HUVEC, Aortic Endothelial, Aortic Smooth Muscle, Coronary Artery Endothelial, Coronary Artery Smooth Muscle Cells.
The current in vitro studies demonstrate an enhanced vasoconstrictor response of small coronary arteries to ET-1 and S6c in pigs with experimental hypercholesterolemia. This response is mediated mainly through the ETB receptor. These alterations in the coronary responsiveness occurred in the setting of long-term elevation of circulating ET-1. These studies support a role for both the ETA and ETB receptors in the regulation of coronary tone in the presence and absence of hypercholesterolemia.. Seo and colleagues12 previously demonstrated that the contractile response of porcine epicardial arteries to endothelins is biphasic; the first phase attained at low concentrations is primarily mediated by the endothelin ETB receptor, whereas both endothelin receptors mediate contraction in the latter, more pronounced phase attained at high concentrations. Takase and colleagues32 found similar results in noncoronary resistance vessels. The current studies extend these previous observations and demonstrate ...
I read with interest the manuscript by Ortiz-Pérez et al. (1) regarding the concordance between the 17-segment American Heart Association model (2) and coronary arterial anatomy using contrast-enhanced cardiac magnetic resonance imaging. In 93 subjects with an acute coronary syndrome, the investigators report a moderately good agreement between the actual and model-predicted coronary artery distribution and suggest that the inferior apical, lateral apical, and mid anterolateral segments are most commonly supplied by the left anterior descending coronary artery (LAD), contrary to what the model predicts.. In a previous study assessing the accuracy of a 17-segment model widely used in the nuclear cardiology literature, we projected the actual coronary artery anatomy of 135 patients undergoing coronary angiography onto the 17-segment model (3). We found that in general the model-predicted coronary anatomy was appropriate. There was only 1 segment (the apical lateral) in which the model-predicted ...
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TY - JOUR. T1 - Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries. AU - Savage, Michael P.. AU - Fischman, David L.. AU - Rake, Randal. AU - Leon, Martin B.. AU - Schatz, Richard A.. AU - Penn, Ian. AU - Nobuyoshi, Masakiyo. AU - Moses, Jeffrey. AU - Hirshfeld, John. AU - Heuser, Richard. AU - Baim, Donald. AU - Cleman, Michael. AU - Brinker, Jeffrey. AU - Gebhardt, Sharon. AU - Goldberg, Sheldon. N1 - Funding Information: This study was supported in part by a grant from Johnson & Johnson Interventional Systems, Inc., Warren, New Jersey. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1998/2. Y1 - 1998/2. N2 - Objectives. The goal of this study was to compare the efficacy of elective stent implantation and balloon angioplasty for new lesions in small coronary arteries. Background. Palmaz-Schatz stents have been designed and approved by the Food and Drug Administration for use in coronary arteries with diameters ≤3.0 mm. The efficacy of ...
1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries.. 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. The density of specific binding sites was higher (maximum binding site density 231 ± 14 fmol/mg of protein) in the small coronary arteries than in the large epicardial coronary arteries (maximum binding site density 108 ± 5 fmol/mg of protein). β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media.. 3. In coronary artery from patients with coronary heart ...
To the best of our knowledge, this is the first reported case of percutaneous coronary intervention (PCI) on RCA ostial stenosis after re-do AVR. Coronary ostial stenosis after AVR is rare and occurs most often in the left main coronary artery, but the RCA can also be affected. An autopsy report revealed that thickened tissue in the aortic root and proximal coronary artery showed fibrosis and intimal thickening and no evidence of atherosclerosis on histological examination [1]. This phenomenon has been proposed to be due to turbulent flow around the prosthetic valve leading to obstruction of the coronary ostia. Fibrotic thickened tissue protrusion was also observed in our case, which was confirmed with homogeneous low echogenicity on IVUS.. Although the pathophysiological mechanism of coronary ostial stenosis after AVR is not well understood, various mechanisms could have mutually influenced this case according to previous studies. First, there could be micro-injury and local hyperplastic ...
The present study demonstrates the modulated expression of the adhesion molecule E-selectin via angiotensin II in human coronary endothelial cells. Evidence for this pathway was obtained from measurements of increased antigen expression at the protein level as well as from increased mRNA content. Functionally, the angiotensin II-induced expression of E-selectin leads to an increase of HL-60 cell adhesion, as demonstrated under near-physiological flow conditions. The effects of angiotensin II on E-selectin expression appear to be mediated by an AT1 (angiotensin II) receptor, since the AT1-receptor antagonist DUP 753 but not the AT2-receptor antagonist PD 123177 suppressed E-selectin-dependent adhesion. These observations indicate a link between the renin-angiotensin system and the expression of E-selectin, which is thought to play a crucial role in the processes of inflammation and atherosclerosis.1 26 27 Adhesion molecule expression on endothelial cells after stimulation with angiotensin II was ...
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 Oct; 61(4):429-439. . View in PubMed. The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. . View in PubMed. Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration Cell Stem Cell. 2017 12 07; 21(6):712-714. . View in PubMed. Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells J Biosci. 2016 Dec; 41(4):659-666. . View in PubMed. The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. . View in PubMed. Alterations of voltage-dependent K(+) channels in ...
The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining techniques in transverse sections taken from the upper, middle, and lower segments of the anterior part of the interventricular region and the adjacent parts of the right and left ventricles containing epicardial nerves and the endocardial peripheral parts of the Purkinje fibers. In total, 317 epicardial nerves were detected. The vasa nervorum were present in 75.7% of these nerves. The vasa nervorum resembled arterioles and postcapillary and collecting venules. One hundred and forty nine epicardial nerves were perivascular, located in the adventitia of the anterior interventricular artery and vein. The remaining 168 nerves ran freely through the epicardial interstitium. The presence of ...
Coronary artery disease is a condition in which the coronary arteries are narrowed by deposits called plaques.. The coronary arteries originate from the aorta and supply blood and oxygen to your heart muscle allowing it pump blood to the body. Normal coronary arteries allow blood to flow freely. However, these arteries can become narrowed by inflammatory fatty deposits called plaques. This disease process is called atherosclerosis. Atherosclerosis that occurs in the coronary arteries is called coronary artery disease.. These plaques build up over time and can decrease the amount of oxygen reaching your heart. Mild coronary artery disease may develop over decades without any symptoms. More severe coronary artery disease can cause chest pain, called angina, and shortness of breath.. If a plaque suddenly ruptures, a blood clot can form and block the hearts blood supply. This is called a heart attack and it can cause permanent damage to the heart. Over time, severe coronary artery disease can also ...
Background. Experimental studies on the effects of alpha2-adrenoceptors on regional coronary blood flow in normal and ischemic myocardium are highly controversial. A beneficial effect on regional ischemic myocardium has been demonstrated in different animal preparations with either alpha2-adrenoceptor blockade or stimulation. Animal studies also demonstrated that postsynaptic alpha2-adrenoceptors mediate vasoconstriction in coronary and femoral vascular beds. The aims of the study were 1) to investigate the effects of regional alpha2-adrenoceptor stimulation on regional coronary blood flow in subjects with angiographically normal coronary arteries, 2) to assess the effect of alpha2-adrenoceptor blockade on coronary circulation in control subjects, and 3) to examine the influence of atherosclerosis on coronary blood flow response to alpha2-adrenoceptor blockade. Methods and Results. The effect of regional administration of BHT 933 (a selective alpha2-adrenoceptor agonist) was studied in eight ...
Previously we reported that the P2Y2 receptor (P2Y2R) is one of the predominant purinergic receptors expressed in human coronary artery endothelial cells (HCAEC), and that P2Y2R activation by ATP or UTP induces dramatic up-regulation of tissue factor (TF), key initiator of the coagulation cascade. However, the molecular mechanism of this P2Y2R-TF axis remains unclear. Here we report a role of a newly identified AP-1 consensus sequence along with its new binding components in P2Y2R regulation of TF transcription. We identified with bioinformatics tools that a novel AP-1 site at -1363 bp of human TF promoter region is highly conserved across multiple species. P2Y2R activation increased TF promoter activity and mRNA expression in HCAEC. Truncation, deletion, and mutation of this new distal AP-1 site all significantly supressed TF promoter activity in response to P2Y2R activation. EMSA and ChIP assays further confirmed that upon P2Y2R activation, c-Jun, ATF-2 and Fra-1, but not the typical c-Fos, ...
The effect of a new coronary vasodilator (Persantin), which produces a marked increase in coronary blood flow (up to 159 per cent in normal animals) without increasing cardiac contractility or cardiac work, has been studied in the experimental animal. This is associated with a marked decrease in coronary resistance. There is an increase in the coronary venous oxygen content and a decrease in the coronary A-V oxygen difference; the cardiac output is only slightly affected. Increase in the coronary blood flow has also been observed in dogs in which coronary in sufficiency has been produced by coronary ligation and by narrowing of the lumen of the coronary artery by the application of casein rings. This was accompanied by no significant increase in cardiac work.. ...
In this study, we investigate plaques located at the left coronary bifurcation. We focus on the effect that the resulting changes in wall shear stress (WSS) and wall pressure stress gradient (WPSG) have on atherosclerotic progress in coronary artery disease. Coronary plaques were simulated and placed at the left main stem and the left anterior descending to produce ,50% narrowing of the coronary lumen. Computational fluid dynamics analysis was carried out, simulating realistic physiological conditions that show the in vivo cardiac haemodynamic. WSS and WPSG in the left coronary artery were calculated and compared in the left coronary models, with and without the presence of plaques during cardiac cycles. Our results showed that WSS decreased while WPSG was increased in coronary side branches due to the presence of plaques. There is a direct correlation between coronary plaques and subsequent WSS and WPSG variations based on the bifurcation plaques simulated in the realistic coronary ...
To study the role of 320-detector coronary computed tomography angiography (CTA) in assessing native coronary arteries in patients treated with coronary stents. 123 patients with coronary stenting received both CTA and conventional coronary angiography (CCA) within 1 day. The clinical parameters, coronary calcium scoring, CTA and CCA were analyzed to determine the prevalence of significant stenosis of native coronary arteries (SSNCA), the predictive value of CTA and the factors correlating with SSNCA and newly developed SSNCA after stenting (NDSSNCAS), with CCA as the standard of reference, using both vessel-based analysis (VBA) and patient-based analysis (PBA). Both the source and the reconstructed images were analyzed by CTA. All native coronary arteries were interpretable independent of cardiac motion. CTA showed a sensitivity/specificity of 93.5 %/97.3 % and 92.5 %/92.5 % in diagnosing SSNCA in VBA and PBA, respectively. The significant factors related to SSNCA were higher calcium scores (P ...
The main goal of AIM III is to assess and quantify the effect of long-term administration of darapladib 160 mg once a day, a selective, reversible, orally active inhibitor of plasma and vascular Lp-PLA2, on coronary endothelial function, progression of coronary atherosclerosis as determined by intravascular ultrasound (IVUS), and atherosclerosis in patients with early atherosclerosis. Patients with evidence of coronary endothelial dysfunction, as determined by intracoronary administration of acetylcholine during angiography and IVUS, will be followed for 6 months during once daily dosing of darapladib. Coronary endothelial function is determined by the changes in coronary artery diameter and coronary blood flow response to the intracoronary administration of acetylcholine and adenosine. The patients will be followed in clinic 6 months. They will have follow-up angiography, assessment of endothelial function, and IVUS during the six month visit ...
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Although atherosclerosis is a systemic disease, plaque progression and complications occur in a focal, patchy pattern. It remains challenging to predict which segments of a given coronary artery will show accelerated progression of atherosclerosis.. Coronary endothelial dysfunction, characterized by a segmental vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine, is considered the earliest stage of atherosclerosis in patients with angiographically nonobstructive coronary arteries. Therefore, sites with endothelial dysfunction may signal future progression of segmental coronary atherosclerosis (1). Using serial intravascular ultrasound (IVUS) imaging, we tested the hypothesis that coronary segments with endothelial dysfunction are associated with plaque progression in patients with nonobstructive coronary artery disease.. In this prospective study, 22 patients underwent coronary angiography with coronary endothelial function assessment and IVUS for clinical purposes ...
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Definitive diagnosis of coronary artery spasm often begins with a coronary angiogram that is performed with the expectation of finding atherosclerotic narrowing of a heart artery. Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. Two patients had coronary artery disease, and three had angiographically normal coronary arteries.. Acting fast at the first sign of heart attack symptoms can save your life and limit damage to your heart. Whether you have had a heart attack or not, if you feel depressed, tell your doctor. You can even have a silent heart attack, one with no symptoms. The symptoms of a heart attack can vary from person to person. To prevent a heart attack, you will most likely need to make lifestyle changes. The patient may need to be hospitalized to prevent a heart attack.. Without normal blood flow from the coronary arteries the heart becomes lack of oxygen and vital nutrients ...
5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how 5-HT causes relaxation of coronary arteries has been less investigated. In isolated rat hearts, 5-HT-induced coronary flow increases are partially resistant to the nitric oxide synthase inhibitor Nω-Nitro-L-arginine methyl ester (L-NAME) and are blocked by 5-HT7 receptor antagonists. In the present study, we investigated the role of 5-HT7 receptor in 5-HT-induced coronary flow increases in isolated rat hearts in the absence of L-NAME, and we also evaluated the involvement of endothelium-derived hyperpolarizing factor (EDHF) in 5-HT-induced coronary flow increases in L-NAME-treated hearts with the inhibitors of arachidonic acid metabolism and the blockers of Ca2+-activated K+ channels. In isolated rat hearts, 5-HT and the 5-HT7 receptor agonist 5-carboxamidotryptamine induced coronary flow
Objective: Streptococcus mutans is the leading cause of dental caries worldwide and a causative agent of infectious endocarditis. Collagen binding protein, Cnm, is expressed by about 10% of S.mutans clinical strains. Here, we investigate the role of Cnm in adherence, invasion, and persistence of human coronary artery smooth muscle cells (CASMC) in vitro. Methods: Adherence and Antibiotic Protection Assay: Human cells were infected with wildtype strains of S.mutans and their corresponding cnm mutants: OMZ175, OM50E, LM7, NCTC11060. S.mutans UA159, a natural cnm negative strain, was used as a negative control. For adherence, human cells were infected at MOI 100 and incubated for 30 min at 4oC. For invasion, human cells were infected at MOI 100 for 2 hours, washed, antibiotic treated for 3 hours to kill extracellular bacteria. Cells were lysed, serially diluted and plated on BHI, and CFUs determined. Quantitative PCR: Antibiotic protection assay with strain OMZ175 was completed, except cells were ...
TY - JOUR. T1 - Angina Due to Coronary Microvascular Disease in Hypertensive Patients without Left Ventricular Hypertrophy. AU - Brush, J. E.. AU - Cannon, R. O.. AU - Schenke, W. H.. AU - Bonow, R. O.. AU - Leon, M. B.. AU - Maron, B. J.. AU - Epstein, S. E.. PY - 1988/11/17. Y1 - 1988/11/17. N2 - When angina occurs in patients with hypertension, it is usually attributed to coronary artery disease or left ventricular hypertrophy. To determine the contribution of coronary microvascular abnormalities to angina in patients with hypertension, we evaluated hypertensive patients without coronary artery disease or left ventricular hypertrophy by measuring the coronary responses to rapid atrial pacing before and after administration of ergonovine. We compared 12 hypertensive patients who had pacing-induced angina with 13 normotensive subjects without such angina. The two groups had similar coronary flow (in the great cardiac vein) at rest; however, pacing increased coronary flow less in hypertensive ...
The bioavailability of nitric oxide (NO) in the human coronary circulation at rest and after acetylcholine (ACH)-induced vasodilation was investigated in 32 patients with angiographically normal coronary arteries. The effects of intracoronary L-NG monomethyl arginine (L-NMMA) were investigated at rest and after ACH, sodium nitroprusside, and adenosine. L-NMMA (64 mumol/min) increased resting coronary vascular resistance by 22% (P , 0.001), reduced distal epicardial coronary artery diameter by 12.6% (P , 0.001), and inhibited ACH-induced coronary epicardial and microvascular vasodilation. These effects were reversed with intracoronary L-arginine. L-NMMA did not inhibit dilation in response to sodium nitroprusside and adenosine. 23 patients were exposed to one or more coronary risk factors. The vasoconstrictor effect of L-NMMA on the epicardial and microvessels was greater in patients free of risk factors: Coronary vascular resistance was 36% higher in patients without risks, compared to 17% ...
Time resolved coronary vessel wall imaging using TRAPD successfully restored the negative polarity of lumen signal and enhanced lumen-wall contrast in the cine images in flow-phantom (Figure 1), and in both normal and subjects with coronary risk factors (Figure 2). The acquisition and utilization of the additional frames increased the cumulative success rate of acquiring at least one adequate-quality image from 76% in single-image acquisitions to over 90% when five frames were acquired. Utilizing multiple consecutive frames in calculations achieved more separation between the normals and patients mean wall thickness values, and with more precision demonstrated by a narrower standard deviation. The difference in vessel wall thickness between the two subject groups was statistically significant (p,0.05) when using TRAPD (1.07 mm vs. 1.46 mm; 36% increase) compared to single-frame DIR imaging (1.24 mm vs. 1.55 mm; 25% increase). ...
Problem statement: Stent thrombosis, which may occur even one year after stent implantation, is a drawback of Drug-Eluting Stents (DES). Among the variety of causes of stent thrombosis after DES implantation, coronary endothelial dysfunction manifested or exaggerated by DES implantation should not be overlooked. This review article summarizes previous reports on coronary endothelial dysfunction after DES implantation and/or coronary spasm and discusses the mechanism, clinical implications and prognosis. Although novel stents that do not impair endothelial function will most likely be developed in the near future, millions of patients have already undergone implantation of a first or second generation DES. Conclusion/Recommendations: Some studies have reported that a drug improves the impairment of endothelial function. On the other hand, no direct relationships between spasm and stent thrombosis after DES implantation have been reported. A larger study is warranted to clarify the clinical significance
Coronary artery disease is among the most common causes of disability and death. Often, by the time symptoms occur, the process may already be far advanced. Frequently,t he first symptom of coronary artery disease is heart attack and sudden death. Dangerous coronary artery disease may be present in individuals that are totally asymptomatic. A recent study showed that a family history of early-onset coronary artery disease (CAD) is associated with significant amounts of plaque in the coronary arteries apparently healthy patients.. Researchers demonstrated a significant amount of plaque present (coronary plaque burden) in apparently healthy middle-aged close relatives of individuals with early-onset of coronary artery disease. This study underscores the fact that asymptomatic patients may benefit from early cardiac screening and that is especially true for individuals with a family history of early-onset CAD may benefit from screening for subclinical atherosclerosis.. The Cardiac portion of the ...
Coronary artery disease is currently the leading cause of death and disability in the United States. Doctors have identified risk factors for treating and delaying cardiac disease, and testing has increasingly become more sophisticated. One of these tests that doctors order and assess carefully is the coronary artery calcium score, or CAC. While it is an independent predictor of coronary artery disease, the score is combined with information from conventional cardiac risk factors to provide very useful information.. In coronary artery disease, a fatty material called plaque narrows the coronary artery diameters and limits blood flow crossing the heart. This most common cause of heart disease in both women and men leads to chest pain, heart attack, arrhythmia, and in advanced cases, heart failure. Coronary artery calcium screening is done with an electron beam CT scan which looks for coronary calcium on the cardiac vessel walls. Calcification within the arteries can be one of the earliest signs ...
Coronary angiography (an-jee-OG-ra-fee) is a test that uses dye and special x rays to show the inside of your coronary arteries. The coronary arteries supply blood and oxygen to your heart. A material called plaque can build up on the inside walls of the coronary arteries and cause them to narrow. When this happens, its called coronary artery disease (CAD). This can prevent enough blood from flowing to your heart and can lead to angina (an-JI-nuh or AN-juh-nuh) (chest discomfort or pain) and heart attack. Coronary angiography shows if you have CAD. Most of the time, the coronary arteries cant be seen on an x ray. During coronary angiography, a special dye is injected into the bloodstream to make the coronary arteries show up on an x ray. To deliver the dye to your coronary arteries, a procedure called cardiac catheterization (KATH-e-ter-i-ZA-shun) is used. A long, thin, flexible tube called a catheter is put into a blood vessel in your arm, groin (upper thigh), or neck. The tube is then ...
The Coronary Stents Market market report provides an overview of Coronary Stents Market, as well as its PEST Analysis. Additionally, the report provides insight on the Coronary Stents Market market share of the individual Coronary Stents Market devices, current and forecasted Coronary Stents Market market size from 2018 to 2026 segmented by seven major markets. The report also covers the market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.. Coronary Stents Overview. Coronary stents are strechable devices that are used to expand the arteries in patients that can further stop the blockage caused in the arteries. Some patients suffer from coronary diseases due to the build-up of plaque in arteries. Therefore, coronary stents can be used in expanding the narrowed arteries, exempting any chance of heart attack or other coronary disorders within patients.. Request free sample copy- ...
Chest pain;Pulmonary vein thrombosis;Coronary artery stenosis;Syndrome X;64-MDCT Chest pain is a typical symptom of ischemic coronary artery diseases. Patients with ischemic coronary artery diseases typically have coronary artery stenosis, although approximately 10-20% of patients with angina pectoris have normal coronary artery, and most of these patients are syndrome X that showed slow coronary flow [1] ; [2]. In addition, patients with chest pain but with an intact coronary artery stenosis were reported [3] ; [4]. Although occlusion of the small coronary arteries has been suggested as a cause of chest pain and atherosclerosis [5], the origin of the microclots that cause coronary artery occlusions remains unknown. Pulmonary vein thrombosis was hypothesized to be a rare complication associated with lung cancers and thoracic surgeries; however, since 2012, I have published several cases of pulmonary vein thrombosis in elderly patients with chest pain using a 64-slice multidetector CT (64-MDCT) ...
TY - JOUR. T1 - Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus. T2 - Implications for reactive oxygen species. AU - Bagi, Zsolt. AU - Feher, Attila. AU - Beleznai, Timea. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Type 2 diabetes mellitus is associated with clustering of cardiovascular risk factors that may greatly increase individuals risk of developing coronary artery disease. Type 2 diabetes is believed to impair coronary function. However, its impact on the vasomotor function of coronary resistance vessels in humans is still debated. Reduced, preserved or even augmented dilations of coronary arterioles have been reported in subjects with type 2 diabetes. Interestingly, recent studies have suggested that reactive oxygen species (ROS), particularly hydrogen peroxide, may compensate for the loss of the vasodilatory function of coronary microvessels during disease development. Recent interventional clinical trials have yielded largely negative results, and there has ...
Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a small proportion of the dramatically increased risk of atherosclerotic coronary artery disease (CAD) in systemic lupus erythematosus (SLE). However, in these studies, exposure to risk factors was measured only at baseline. In this study, our objective was to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP), and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE. Patients in the Toronto lupus cohort had TC and BP measured at each clinic visit and were followed up prospectively for the occurrence of CAD. For each patient, arithmetic mean, time-adjusted mean (AM) and area-under-the-curve (AUC) were calculated for serial TC, SBP, and DBP measurements. Proportional hazards regression models were used to compare these summary measures with recent and first adds 2014 Research Report on Global and China Coronary Stent Industry report to its research database.. This is a professional and depth research report on Global and China Coronary Stent Industry. Firstly the report describes the background knowledge of Coronary Stent, including Coronary Stent Concepts Classification production process technical parameters; then statistics Global and China 18 Manufacturers Coronary Stent product 2009-2017 Capacity production cost price production value Gross margins and other relevant data, statistics these enterprises Coronary Stent products, customers, raw materials, company background information, then summary statistics and analysis the relevant data of these enterprises. and get Global and China Coronary Stent 2009-2017 production market share, different regions and Type Coronary Stent production market share, Global and China Coronary Stent demand supply and shortage, Global and China Coronary Stent 2009-2017 production price cost ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Coronary Artery Calcium Imaging and Scoring (CAC Score). Coronary artery calcium (CAC) scoring is an easy, convenient, painless, non-invasive imaging technique to detect and evaluate the amount of calcium deposition in the coronary arteries (i.e. blood vessels supplying the heart muscle). It gives an idea of whether early cholesterol plaque have begun to infiltrate the coronary arteries despite the lack of any symptoms and will likely to progress in the years to come.. The degree of calcium deposition corresponds to the severity of the atheromatous plaque and the likelihood of a heart attack (see table 1). The higher the calcium score, the greater the risk and is used by cardiologists as one of the tools to assess and correlate with the risk of adverse cardiovascular events. Although not directly correlated - the higher the calcium score (termed the calcium burden), the greater the chance of more severe narrowing of the coronary arteries. Conversely a low calcium score although suggests a low ...
TY - JOUR. T1 - Diastolic coronary resistance and capacitance are independent of the duration of diastole. AU - Judd, R. M.. AU - Redberg, D. A.. AU - Mates, R. E.. PY - 1991. Y1 - 1991. N2 - Systolic myocardial contraction may produce changes in coronary resistance and capacitance that persist throughout a normal diastole. In addition, coronary resistance and capacitance as determined in the arrested heart may not accurately describe normal diastolic behavior. To evaluate these possibilities, an identification method capable of characterizing the input impedance of the coronary circulation in as little as 150 ms was developed. Using this method, coronary dynamics were measured during early and late diastoles in the beating heart with tone intact as well as during adenosine-induced maximal vasodilation. Coronary dynamics were also measured in the arrested heart during maximal vasodilation. With vasomotor tone intact, the parameters of a lumped model of the coronary circulation showed no ...
Results: The thickness of the arterial wall was measured at the site of 46 regressed aneurysms, 14 sites that showed transient dilatation, and in 78 apparently normal coronary arteries that did not show any dilated lesions using two-dimensional echocardiography (2DE) after the acute stage of Kawasaki disease. We assessed all the lesions located at segments 1, 5, and 6, according to the American Heart Association classification; we also obtained corresponding measurements for normal coronary arteries. In children aged less than 14 years, no cross-sectional arterial wall was detected in 65 apparently normal coronary arteries, probably because these arteries were too thin to be detectable using MR imaging. However, cross-sectional arterial thickness was detected in 18 of the 38 regressed aneurismal walls and in 3 out of the 11 sites assessed after transient dilatation. There is no significant relationship between the thickness and the diameter of the aneurysms measured using 2DE in the acute phase ...
2] Coronary sinus ASDs are believed to arise from developmental failure of formation of the wall between the coronary sinus and the left atrium.. The coronary sinus is a systemic venous structure embryologically derived primarily from the left common cardinal vein that is continuous with the left anterior cardinal vein. Coronary sinus ASDs involve the inferior and anterior interatrial septa at the usual location of the orifice of the coronary sinus. The orifice of the coronary sinus becomes continuous with the left atrial chamber when a defect occurs in the wall separating the left atrium from the coronary sinus. This arrangement allows shunting between the atria.. From the right atrial aspect of the interatrial septum, the defect may consist of the coronary sinus orifice alone or with additional deficiency of atrial septal tissue around the coronary sinus orifice. On the left atrial side, the defect consists of partial or complete unroofing of the coronary sinus, if the entire superior aspect ...
Acute coronary obstruction occurred in two patients during coronary angiography. In one case the obstruction was in the left main coronary artery; in the other it was close to the origin of the left anterior descending artery. In both cases acute cardiac ischaemia ensued, with electromechanical dissociation and collapse, which was not reversible by resuscitation. Rapid disobliteration of the occluded coronary artery was done with a guide-wire pushed through the obstruction via the coronary catheter. The recanalisation was completed by an intracoronary perfusion of streptokinase in one case. In both cases recovery was rapid and spectacular. The occurrence of acute ischaemia during coronary angiography should suggest accidental coronary occlusion. If a thromboembolic origin is suspected, transluminal disobliteration should be attempted. It is simple and can reverse a dangerous condition ...
A coronary stent is a tubular structured device made of a thin mesh of wire, which may also be coated with a polymer containing a drug, or made of biodegradable materials. Coronary stents are utilized during percutaneous coronary interventions (PCIs) for the treatment of patients suffering from various coronary artery diseases (CADs) such as acute myocardial infarction, angina pectoris and others. At present, several researches are being conducted in the field of coronary stenting, in order to minimize side effects such as restenosis and thrombosis. Certain new and advanced coronary stents such as bio-absorbable stents have been commercialized in the global market, which demonstrate very less or no common side effects of coronary stenting.. Request a Sample Copy of the Report @ The market for coronary stents can be broadly classified into three major segments, namely, bare metal stents (BMS), drug eluting stents (DES) and bio-absorbable stents. In 2011, the drug ...
However, the epicardial coronary vessels (the vessels that run along the outer surface of the heart) remain open. Because of ... Coronary circulation is the circulation of blood in the blood vessels that supply the heart muscle (myocardium). Coronary ... The third sinus, the right posterior aortic sinus, typically does not give rise to a vessel. Coronary vessel branches that ... the subendocardial coronary vessels (the vessels that enter the myocardium) are compressed due to the high ventricular ...
Nicotine constricts blood vessels. This includes coronary blood vessels and those in the skin. However, blood vessels in the ... Nicotine does promote the growth of blood vessels that supply tumors and it speeds tumor growth. Whether long-term vaping can ... In reaction to nitric oxide, it hinders endothelial-dependent widening of blood vessels. It is associated with stroke, ... No published research is available on vaping and thrombosis, platelet reactivity, atherosclerosis, or blood vessel function. ...
Reese DE, Zavaljevski M, Streiff NL, Bader D (May 1999). "bves: A novel gene expressed during coronary blood vessel development ... Blood vessel epicardial substance (BVES) also known as popeye domain-containing protein 1 (POPDC1) is a protein that in humans ...
2008). "Drug-eluting or bare-metal stents forlarge coronary vessel stenting? The BASKET-PROVE (PROspective Validation ...
Coronary arteries are the blood vessels that supply to the heart for its normal function. Blood vessel disorders occur in ... This can occur in various locations such as coronary blood vessels, peripheral arteries and veins. The narrowed arteries would ... It is then guided along the artery to the targeted blood vessel to be examined. An imaging dye is loaded into the blood vessel ... When the rate of blood flow is too low, there may be a blockage of vessel. By evaluating blood flow in vessels, the severity ...
The heart is supplied by coronary vessels and therefore CPP is the pressure within those vessels. If pressures are too low in ... Coronary arteries Coronary circulation Coronary artery disease Costanzo, Linda S. (2011). Physiology (5th ed.). Philadelphia: ... Therefore, it is only when the heart relaxes, during diastole, that the coronary vessels open up and allow for perfusion; thus ... During cardiac surgery, when a patient is placed on cardiopulmonary bypass, and blood is passed through the coronary vessels in ...
The surgery has recently begun to be used in multi-vessel coronary disease. People with multi-vessel coronary disease, who ... Minimally invasive direct coronary artery bypass (MIDCAB) is a surgical treatment for coronary heart disease that is a less ... A hybrid approach combines coronary bypass (using the MIDCAB approach) and coronary stenting. Cardiac surgeon Cardiac surgery ... MIDCAB is a form of off-pump coronary artery bypass surgery (OPCAB), performed "off-pump" - without the use of cardiopulmonary ...
In atherosclerosis, a severe disease in modern society, coronary blood vessels occlude. These vessels have to be freed and held ... Usually autologous vessels from the patient or synthetic polymer grafts are used for this purpose. Both options have ... Firstly there are only few autologous vessels available in a human body that might be of low quality, considering the health ... Unfortunately after certain time these vessels close again and have to be bypassed to allow for upkeep of circulation. ...
Coronary angiography can visualize coronary artery stenosis, or narrowing of the blood vessel. The degree of stenosis can be ... Additionally, damage to blood vessels can occur at the site of puncture/injection, and anywhere along the vessel during passage ... which allows the interventional radiologist to evaluate the flow of the blood through a vessel or vessels. This technique " ... The dye highlights the blood vessels in the back of the eye so they can be photographed. This test is often used to manage eye ...
Pearl McBroom developed new ways of observing changes in coronary blood vessel tissue. Ernest Mae McCarroll in 1946 became the ...
MRI coronary vessel wall imaging, although currently limited to research studies, has demonstrated the ability to detect vessel ... There was incremental significant increase in CIMT with the number coronary vessel involved. In accordance with the literature ... Magnetic Resonance Coronary Vessel Wall Imaging Detects Positive Arterial Remodeling in Patients With Nonsignificant Coronary ... Angiogram ApoA-1 Milano Atherosclerosis Atherothrombosis Coronary circulation Coronary catheterization EBT Hemorheologic- ...
This drug can be administered intravenously to dissolve blood clots in coronary vessels. However, streptokinase causes systemic ... A thrombus in a large blood vessel will decrease blood flow through that vessel (termed a mural thrombus). In a small blood ... Mural thrombi are thrombi that adhere to the wall of a large blood vessel or heart chamber. They are most commonly found in the ... Mural thrombi are thrombi that adhere to the wall of a large blood vessel or heart chamber. They are most commonly found in the ...
Coronary artery bypass graft: using another blood vessel to replace and divert blood around an occluded vessel to maintain ... A plaque can lead to obstruction of the blood vessel and if this were to occur in a coronary artery it could increase the risk ... "Cardiac Catheterization and Coronary Angiography - Heart and Blood Vessel Disorders - Merck Manuals Consumer Version". Merck ... Coronary Artery Disease (also known as coronary heart disease or ischemic heart disease) is a result of the build-up of ...
However this method risked lung and coronary blood vessel damage, cardiac tamponade and arrythmias. EMB, sampling myocardium, ...
He developed specialized pre-shaped catheters to reach the coronary vessels via the aorta. Today, they are commonly used and ... One of the Best of a Rare Breed: Melvin Paul Judkins, A Pioneer in Coronary Arteriography. Accessed May 1, 2020. Cowley MJ ( ... Judkins MP (1967). "Selective Coronary Arteriography". Radiology. 89 (5): 815-824. doi:10.1148/89.5.815. ISSN 0033-8419. PMID ... benefits of a newly fitted laboratory where he worked with colleagues to utilize these techniques to develop selective coronary ...
Notably, cardiac muscle perfusion through the heart's coronary vessels doesn't happen during ventricular systole; rather, it ... coordinated depolarisation and excitation-contraction coupling from the apex of the heart up to the roots of the great vessels ...
Pratt, F. H. (1898). "The nutrition of the heart through the vessels of Thebesius and the coronary veins". American Journal of ...
Similar stents and procedures are used in non-coronary vessels (e.g., in the legs in peripheral artery disease). An artery with ... The MASS-II trial compared PCI, CABG and optimum medical therapy for the treatment of multi-vessel coronary artery disease. The ... A coronary stent is a tube-shaped device placed in the coronary arteries that supply blood to the heart, to keep the arteries ... It is used in a procedure called percutaneous coronary intervention (PCI). Coronary stents are now used in more than 90% of PCI ...
The coronary arteries are the arterial blood vessels of coronary circulation, which transport oxygenated blood to the heart ... Coronary circulation Left coronary artery Right coronary artery Heart Cardiology Coronary artery disease Angina Unstable angina ... The coronary arteries wrap around the entire heart. The two main branches are the left coronary artery and right coronary ... The coronary arteries are mainly composed of the left and right coronary arteries, both of which give off several branches, as ...
In February 2004, he was hospitalized with a coronary lesion and a damaged blood vessel. In October he was again in hospital ...
Shepherd, JT; Wood, EH (May 1959). "The role of vessel tone in pulmonary hypertension". Circulation. 19 (5): 641-645. doi: ... particularly in the coronary arteries, in man". Am J Cardiol. 32 (2): 144-150. doi:10.1016/s0002-9149(73)80112-2. PMID 4578631 ... Smith, HC; Sturm, RE; Wood, EH (August 1973). "Videodensitometric system for measurement of vessel blood flow, ...
CGRP induces vasodilatation in a variety of vessels, including the coronary, cerebral and systemic vasculature. Its abundance ...
Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for ...
... carrying out coronary angioplasty (opening narrowed or blocked blood vessels that supply blood to the heart); coronary stenting ... placing tube-shaped devices into the coronary arteries that supply blood to the heart to keep them open); as well as other ... interventions to correct blood flow, repair holes in the heart or locate blockages in blood vessels. In December 2020, the ...
Percutaneous coronary intervention (PCI) - Procedures to treat stenotic coronary arteries by accessing through a blood vessel. ... Coronary artery disease (CAD)- Coronary artery disease is a general term for any reduction in coronary circulation. One such ... Diseases of blood vessels - diseases of the blood vessels can be multidisciplinary in nature. For example, medical treatment of ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ...
Coronary small vessel disease is a type of coronary heart disease that affects the arterioles and capillaries of the heart. ... Coronary small vessel disease is also known as microvascular angina, microvascular dysfunction, non-obstructive coronary ... It can be contrasted to coronary heart disease, an angiopathy that affects the larger vessels. Cerebral small vessel disease ... In this case, high blood glucose levels cause the endothelial cells lining the blood vessels to take in more glucose than ...
Cardiac imaging techniques include coronary catheterization, echocardiogram, intravascular ultrasound, retinal vessel analysis ... High frequency analysis of the QRS complex may be useful for detection of coronary artery disease during an exercise stress ... to assess the evolution of coronary artery disease and evidence of existing damage. A great many more physiologic markers ... and the coronary calcium scan. Cardiology Reference ranges for common blood tests Medical technologist Gerald, F; Philip, A; ...
Integrating this therapy with percutaneous coronary angioplasty (hybrid procedure) offers multi-vessel revascularization ... Thus hybrid coronary revascularization and MIDCAB (minimally invasive direct coronary artery bypass surgery) have been ... For people who undergo coronary artery bypass grafting, coronary imaging (completion angiography) for the routine evaluation of ... Cardiac catheterization is the insertion of a catheter into the heart through a blood vessel. The cardiac catheter can then be ...
The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... "The U wave is the momentum carried by the blood in the coronary arteries and blood vessels". The resistivity of stationary ... which gradually increases high up in the coronary arteries and blood vessels. ... The interior of a blood vessel includes a near-wall layer of plasma (referred to as lubricant), the size of which strictly ...
... is thought to heal coronary and blood vessels diseases, increased blood pressure and rheumatic disorders. It also ...
... for coronary artery disease in multiple vessels Developed the first steerable coronary guidewire First advanced coronary ...
414.11 Aneurysm of coronary vessels 414.12 Dissection of coronary artery 414.8 Ischemic heart disease, chronic, other 414.9 ... Angina pectoris 413.0 Angina decubitus 413.1 Prinzmetal angina 414 Other forms of chronic ischemic heart disease 414.0 Coronary ... acquired 448 Disease of capillaries 449 Septic arterial embolism 451 Phlebitis and thrombophlebitis 451.1 Of deep vessels of ... Other acute and subacute forms of ischemic heart disease 411.0 Postmyocardial infarction syndrome 411.1 Intermediate coronary ...
Microrobot moving controlled through blood vessel for drug delivery and treatment of coronary artery disease such as CTO( ...
... below Coronet or coronary band: the ring of soft tissue just above the horny hoof that blends into the skin of the leg Crest: ... as well as the blood and blood vessels. Its main purpose is to circulate blood throughout the body to deliver oxygen and ...
Study of blood flowing vessels by ultrasonics 1959 Among which: Réunion de chirurgie vasculaire Hôpital Saint Joseph ... and completing Coronary artery bypass surgery, more and more necessary for the aging population. Several randomized controlled ... then tried to analyze more exactly the hemodynamic meaning of the Doppler signal wave from normal and diseased vessels. He ...
... syndactyly jejunal atresia Coronaro-cardiac fistula Coronary arteries congenital malformation Coronary artery aneurysm Coronary ... lipoid Congenital afibrinogenemia Congenital alopecia X linked Congenital amputation Congenital aneurysms of the great vessels ...
Coronary artery disease (narrowed coronary arteries) Arrhythmia (irregular heartbeat) Cardiomyopathy (disease of the heart ... Skeletal muscle includes skeletal muscle fibers, blood vessels, nerve fibers, and connective tissue. Skeletal muscle is wrapped ... and smooth muscle is found in hollow structures such as the walls of intestines or blood vessels. The fibres of striated muscle ...
A coronary CT calcium scan is a computed tomography (CT) scan of the heart for the assessment of severity of coronary artery ... catheterization uses pressure monitoring and blood sampling through a catheter inserted into the heart through blood vessels in ... Coronary angiography is used to determine the patency and configuration of the coronary artery lumens. Intravascular ultrasound ... "Assessment of Agatston Coronary Artery Calcium Score Using Contrast-Enhanced CT Coronary Angiography". American Journal of ...
So, the blood vessels found specifically in the brain respond changes in dissolved carbon dioxide levels. Coronary (heart) ... or increased shear stress on the blood vessel (meaning the amount of stress exerted by blood on the blood vessel walls). While ... which triggers the blood vessel to vasodilate. Myogenic control, which originates from the wall of the blood vessel itself and ... For example, if a muscle is actively being utilized it will require more oxygen than if it was at rest, so the blood vessels ...
... blood and blood vessels. Angina Acute coronary syndrome Anomic aphasia Aortic dissection Aortic regurgitation Aortic stenosis ... Ischemic heart diseases Angina pectoris Acute coronary syndrome Acute myocardial infarction See also Category:Valvular heart ...
Unlike angioplasty and stents, which push plaque into the vessel wall, atherectomy cuts plaque from the wall of the artery. ... It has also been used to treat coronary artery disease, albeit without evidence of superiority to angioplasty. Atherectomy is ... Atherectomy is a minimally invasive technique for removing atherosclerosis from blood vessels within the body. It is an ... Wasiak J, Law J, Watson P, Spinks A (December 2012). "Percutaneous transluminal rotational atherectomy for coronary artery ...
... dilation of blood vessels, and fluctuations in blood pressure. There are medical reports of occasional heart attacks or ... particularly those with some degree of coronary artery or cerebrovascular disease, poses greater risks due to the resulting ... congestion of the conjunctival blood vessels), a reduction in intra-ocular pressure, muscle relaxation and a sensation of cold ...
Something that is patent may also refer to a channel such as a blood vessel, section of bowel, collecting system or duct that ... like that encountered in vital arteries such as coronary arteries and cerebral arteries), or another unspecified obstruction, ... such as blood vessels or leaf veins. Patent, meaning a structure such as an artery or vein that abnormally remains open, such ...
Coronary angiography is a diagnostic procedure that allows visualization of the coronary vessels. Fluoroscopy is used to ... The coronary arteries are known as "epicardial vessels" as they are located in the epicardium, the outermost layer of the heart ... These comorbidity conditions include aortic aneurysm, aortic stenosis, extensive three-vessel coronary artery disease, diabetes ... coaxially into the blood vessel.[citation needed] Once access is obtained, what is introduced into the vessel depends on the ...
... in the coronary vessels. Patients with pheochromocytoma present with myocardial infarctions despite an overall lack of plaque ... The normal blood vessel is open, allowing for adequate blood flow. When catecholamines activate the alpha receptor, the vessel ... Norepinephrine causes vessels to narrow, thereby limiting blood flow and inducing ischemia. Multiple organ dysfunction syndrome ... This complication is related to the impact that alpha and beta-adrenoceptor antagonists have on blood vessels combined with the ...
Its uses included angiography (imaging of blood vessels and heart chambers) and urography (imaging of the urinary tract), but ... in patients with coronary heart disease". European Radiology. 7 Suppl 4: S156-61. doi:10.1007/pl00006885. PMID 9204361. S2CID ...
While a single ruptured plaque can be identified during autopsy as the cause of a coronary event, there is currently no way to ... In contrast to conventional angiography, cardiac CT angiography does enable visualization of the vessel wall as well as plaque ... Some of the CT derived plaque characteristics can help predict for acute coronary syndrome. In addition, because these lesions ... 2013). "Additive value of semi-automated quantification of coronary artery disease using cardiac CT-angiography to predict for ...
His research has included work in determining how coronary hemodynamics drive the progression of coronary atherosclerosis1 and ... This research aimed to validate an algorithm to optimizing stent design to minimize or maximize various blood vessel mechanical ... and vessel remodeling as a function of wall shear stress. Timmins was a supporting author on a study exploring how device ... "Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial ...
In 1987, experiments with coronary arteries showed that nitric oxide was the long sought endothelium-derived relaxing factor. ... agents that relax the blood vessels). eNO has also been associated with wheeze, rhinitis and nasal allergy in primary school ...
... blood vessel thickening/hardening) which "plays a central role in common age-associated diseases such as atherosclerosis, ... a novel variant associated with HDL deficiency and premature coronary artery disease". Atherosclerosis. 164 (2): 245-250. doi: ...
... narrowing of vessel). CTA can be used to visualize the vessels of the heart, the aorta and other large blood vessels, the lungs ... Coronary CT angiography (CCTA) is the use of CT angiography to assess the arteries of the heart. The patient receives an ... In this test, a PE will appear as a dark spot inside the blood vessel or a sudden stop of the bright contrast material. CT ... CCTA is able to detect narrowing of blood vessels in time for corrective therapy to be done. CCTA is a useful way of screening ...
A common sign of diabetes is the degradation of blood vessels in various tissues throughout the body. Retinopathy refers to ... Additionally, upregulation of a number of miRNAs has been shown to be associated with acute myocardial infarction, coronary ...
"Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors". European Journal of ... of various brain and peripheral vessel contractility". European Journal of Pharmacology. 411 (3): 289-99. doi:10.1016/S0014- ...
t-PA is released into the blood slowly by the damaged endothelium of the blood vessels, such that, after several days (when the ... They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ...
"Novel stent promotes healing of vessel wall after implantation" Cardiology Today Klomp M, Beijk MA, de Winter RJ (July 2009). " ... The Genous Stent is a bio-engineered coronary stent coated with immobilized anti-CD34 monoclonal antibodies specific to the ... The Combo Dual Therapy Stent is a coronary stent that combines Genous with an antiproliferative, biodegradable sirolimus drug ... capture technology manufactured by OrbusNeich that promotes the accelerated natural healing of the vessel wall after stent ...
The structure contains the trunks of the nutrient vessels of the heart, and is deficient in front, where it is crossed by the ... There are two coronary sulci in the heart, including left and right coronary sulci. The left coronary sulcus originates ... The location of the left coronary sulcus is marked by the circumflex branch of left coronary artery and coronary sinus. The ... the coronary sulcus contains the coronary sinus. In relation to the rib cage, the coronary sulcus spans from the medial side of ...
... and coronary arteries. to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 minutes ... Blood Vessels. 26 (2): 119-27. doi:10.1159/000158760. PMID 2474340. Epstein, Murray MD, "Diagnosis and Management of ...
Following World War II, chelation therapy was used to treat workers who had painted United States naval vessels with lead-based ... He hypothesized that "EDTA could dissolve disease-causing plaques in the coronary systems of human beings." In a series of 283 ... EDTA chelation therapy is not effective as a treatment for coronary artery disease and this use is not approved in the United ... and the overall impact of coronary artery disease" as factors motivating the trial. The study has been criticized by some who ...
The pulmonary circulation system consists of the network of blood vessels from the right heart to the lungs and back to the ... Coronary Heart diseases and Myocardial infarction or Heart attacks. The Computational Fluid dynamics (CFD) models prepared ... The viscosity of blood decreases as the percent of the diameter of a vessel occupied by the cell-free layer increases. However ... The blood flow in arteries and veins are closely linked to the blood vessel properties. Carrying the oxygen and nutrients to ...
Depending on the vessel being imaged, the volume of contrast is tracked using a region of interest (abbreviated "R.O.I.") at a ... Coronary Interventions. doi:10.5772/29992. ISBN 978-953-51-0498-8. Webb, W. Richard; Brant, Wiliam E.; Major, Nancy M. (2014). ... Images are acquired at a rate as fast as the contrast moving through the blood vessels. This method of imaging is used ... This is useful to highlight structures such as blood vessels that otherwise would be difficult to delineate from their ...
Responses of coronary vessels to adrenergic stimuli. Donald R. McRaven, Allyn L. Mark, Francois M. Abboud, and Howard E. Mayer ... The direct effect of these two stimuli on coronary vessels is minimal and is mediated through stimulation of alpha ( ... The left circumflex coronary artery of dogs was perfused with arterial blood at constant flow, and coronary perfusion pressure ... Coronary responses to adrenergic stimuli were determined in the intact beating heart before and after administration of ...
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In patients with small vessels with native CAD, a drug-coated balloon was noninferior to drug-eluting stents for major adverse ...
US-2012004499-A1 chemical patent summary.
Coronary artery, mouse - histology slide This is a histology slide from a coronary artery of a mouse.. Histology slide courtesy ...
... we performed standardized contrast injection of the contralateral coronary artery in 58 consecutive patients, without previous ... To determine the factors that influence the presence of collateral vessels during coronary occlusion, ... Severity of single-vessel coronary arterial stenosis and duration of angina as determinants of recruitable collateral vessels ... right coronary artery: in 10 and left circumflex artery in 3). The presence of collateral vessels during coronary occlusion, ...
Overview of Coronary Artery Disease (CAD) - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - ... Coronary Artery Bypass Grafting Coronary artery bypass grafting (CABG) is also called bypass surgery or coronary artery bypass ... Percutaneous Coronary Intervention Percutaneous coronary intervention or PCI (also called percutaneous transluminal coronary ... The consequences of this acute ischemia are referred to as acute coronary syndromes Acute Coronary Syndromes (Heart Attack; ...
Coronary Disease - pathology - physiopathology Coronary Vessels - pathology - physiopathology - ultrastructure Disease Models, ... Limitation of coronary perfusion of different degree induces inhomogeneous changes in resistance of vessels in the ... Functional and morphological characteristics of coronary vessels in varying degree of coronary perfusion] https://arctichealth. ... an adequate dilatory regulatory reaction may be followed by an increase in resistance of the coronary vessels. An active ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
We studied 350 patients with single-vessel coronary artery disease who underwent a single-site balloon dilation. Sensitivity ... Angioplasty, Transluminal, Percutaneous Coronary, *Coronary Angiography, Angina Pectoris/diagnosis, Coronary Disease/diagnosis/ ... Which angiographic variable best describes functional status 6 months after successful single-vessel coronary balloon ... Which angiographic variable best describes functional status 6 months after successful single-vessel coronary balloon ...
Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? A three-vessel intravascular ... Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? A three-vessel intravascular ... Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? A three-vessel intravascular ...
keywords = "atherogenesis, coronary microvascular dysfunction, coronary wall shear stress, impaired coronary vasomotion, plaque ... Coronary Microvasculature : Are the Small and the Mighty Cross-Talking With the Epicardial Vessels? / Corban, Michel T.; Lerman ... Coronary Microvasculature: Are the Small and the Mighty Cross-Talking With the Epicardial Vessels? JACC: Cardiovascular ... Coronary Microvasculature : Are the Small and the Mighty Cross-Talking With the Epicardial Vessels?. In: JACC: Cardiovascular ...
AGE-RELATED CHANGES IN CATHECHOLAMINERGIC NERVE FIBERS OF RAT HEART AND CORONARY VESSELS. BRUZZONE, Paolo;CAVALLOTTI, Carlo; ... Conclusion: The decrease of the catecholaminergic innervation of heart and coronary vessels of old rats can be in close ... Conclusion: The decrease of the catecholaminergic innervation of heart and coronary vessels of old rats can be in close ... Methods: Samples of myocardium and/or coronary vessels were studied by means of glyoxylic acid induced fluorescence, aldehyde- ...
... risk factors and complications of Coronary microvascular disease or small vessel heart disease. ... Coronary microvascular disease or small vessel heart disease is a type of heart diseases in which the small arteries of the ... What is Coronary Microvascular Disease or Small Vessel Heart Disease?. Coronary microvascular disease or small vessel heart ... Facts about Coronary Microvascular Disease or Small Vessel Heart Disease. *Coronary microvascular disease or small vessel heart ...
Single vessel coronary artery disease. II. Isolated lesions of the left anterior descending coronary artery: Clinical and ... Single vessel coronary artery disease. II. Isolated lesions of the left anterior descending coronary artery: Clinical and ... Single vessel coronary artery disease. II. Isolated lesions of the left anterior descending coronary artery: Clinical and ... presence of collateral vessels, of associated subcritical (50%) lesions of other vessels, of previous myocardial infarction; ...
Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development ... Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development ...
It is mainly the coronary vessels where the so-called coronary stents are used. But other vessels can also be supplied with ... Strictly speaking, a stent stabilizes vessels after they have been dilated, especially in the coronary arteries. ... The idea is that the vessel only needs to be supported for a while, and a stent is a foreign body.These so-called bio-stents ... The blood flow can no longer flow properly due to the narrowing and blockage of the vessels, which can result in a stroke and a ...
The effects of ageing on the coronary vessel wall as assessed by high resolution MR imaging. Vessel wall thickness (a) and W/OW ... Scott, A.D., Keegan, J., Mohiaddin, R.H. et al. MRI detects coronary vessel wall thickening with age in healthy subjects. J ... Cross-sectional vessel wall imaging was performed in the proximal right coronary artery (,40mm from origin) using a 3D spiral ... Recently 3D MR coronary vessel wall imaging with retrospective beat-to-beat respiratory-motion-correction (B2B-RMC)[4], which ...
Restenosis after successful coronary angioplasty in single vessel disease.. Authors: Kaul, U. Rao, Y V. Dev, V. Manchanda, S C ... Kaul U, Rao YV, Dev V, Manchanda SC, Sharma S, Rajani M. Restenosis after successful coronary angioplasty in single vessel ... Coronary angiography was performed only if symptoms and/or objective evidence of ischemia recurred. In this group, restenosis ... Repeat PTCA was done in 30 patients with a 96% success rate; 4 patients required coronary artery bypass grafting (CABG). ...
Browsing by Subject Coronary vessels Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z or enter first few ... Tolerance to an 8mg dose of perindopril for secondary prevention of coronary artery disease. Manduca, Emma; Azzopardi, Lilian M ...
Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year ... Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year ... Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year ... T1 - Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five- ...
Radius of the vessel, resistance and coronary flow Part II Dear Dr. Braile,. In the penultimate edition of our magazine, it was ... "coronary ostium to the coronary sinus [4]. How do we know which capillaries are open and therefore how many will enter the ... Coronary revascularization with the left internal thoracic artery and radial artery: comparison of short-term clinical ... Since that article had a little misconception, when applied to fluid mechanics for a real situation of coronary obstruction, I ...
In the coronary blood vessels, IVL modifies arterial calcium and enables percutaneous coronary interventions to be performed in ... A Novel Approach to Calcium Destruction in Coronary and Peripheral Blood Vessels: Intravascular Lithotripsy. ... A Novel Approach to Calcium Destruction in Coronary and Peripheral Blood Vessels: Intravas ... heavily calcified lesions in both peripheral and coronary vessels. Despite this, more studies are certainly needed to determine ...
A review of coronary vessel segmentation algorithms ...
... Coronary artery disease ( ... Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease. ▼ Noninvasive techniques ... Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease. Filter those results▼ ... Coronary Arteriosclerosis, Coronary Circulation, Coronary Vessels, Severity Of Illness Index, Affiliations:. *** IBB - CNR *** ...
These blood vessels are called the coronary arteries. A coronary artery stent is a small, metal mesh ... Angioplasty is a procedure to open narrowed or blocked blood vessels that supply blood to the heart. ... These blood vessels are called the coronary arteries. A coronary artery stent is a small, metal mesh tube that expands inside a ... Both of these were done to open narrowed or blocked coronary arteries, the blood vessels that supply blood to your heart. You ...
Long Term Outcome Of Hybrid Revascularization In Multi Vessels Coronary Artery Disease In A Single Institution Study. ... Long Term Outcome Of Hybrid Revascularization In Multi Vessels Coronary Artery Disease In A Single Institution Study.. Maria ... CONCLUSIONS: The hybrid coronary revascularisation approach combining EndoACAB to LAD and PCI to non LAD vessels is a safe ... mammary graft to the LAD with PCI to the non-LAD vessels aiming to achieve complete revascularization for multi-vessel coronary ...
  • Results: Our findings are indicative of an age-related decrease of all types of fluorescent sympathetic nerve fibers in rat heart and coronary arteries. (
  • Coronary microvascular disease or small vessel heart disease is a type of heart diseases in which the small arteries of the heart becomes narrow which causes signs and symptoms of heart problems like chest pain (angina). (
  • Coronary microvascular disease or small vessel heart disease is usually diagnosed while doctor examines someone for the blockage in the main arteries of the heart in case of heart problems and fails to find any significant issues even on repeated occurrence of symptoms. (
  • Coronary microvascular disease or small vessel heart disease cause narrowing of arterioles, the smallest coronary arteries of heart. (
  • Coronary microvascular disease is generally caused by the plaque formation in arteries in case of tightening of arteries or in case of any disease or damage to the walls of arteries which stops the oxygen rich blood reaching the muscles of heart. (
  • The larger arteries carry most of the oxygenated blood from heart to different parts of the body and small vessels assist the arteries by when you are active and then contract back when you relax. (
  • Strictly speaking, a stent stabilizes vessels after they have been dilated, especially in the coronary arteries. (
  • These blood vessels are called the coronary arteries. (
  • Both of these were done to open narrowed or blocked coronary arteries, the blood vessels that supply blood to your heart. (
  • The prevalence of congenital anomalies of the coronary arteries is reported to be approximately 0.6%-1.3% of the general population. (
  • In this case, double split right coronary arteries are diseased with these other two left-sided arteries are also having atherosclerosis disease with significant stenosis, labeling this patient as having DQ Four vessel disease. (
  • Variations in coronary arteries anatomy are very often recognized in association with structural forms of congenital heart disease and now as a separate entity. (
  • The contrast injection during CAG revealed two equal caliber right coronary arteries with 70% stenosis in mid portion of one RCA [Figure 2] and 90% stenosis at origin of second RCA [Figure 3]. (
  • We observed atherosclerotic narrowing in both these right coronary arteries. (
  • Coronary arteries supply the heart muscle with blood flow. (
  • However, the so-called coronary arteries originated from different body parts in amniotes and other groups, and the evolution of these arteries remains unclear. (
  • Here we propose that the amniote coronary arteries were newly obtained, overriding the ancestral arterial systems. (
  • In contrast, amphibians ( Xenopus laevis, Hyla japonica, Lithobates catesbeianus , and Cynops pyrrhogaster ) retain the ASV-like vasculature as extrinsic cardiac arteries throughout their lives and have no primitive coronary plexus. (
  • Coronary arteries are blood vessels that supply oxygen and nutrients to the heart muscle. (
  • Anatomical similarities in the origin and distribution of the coronary arteries among extant amniotes corroborate the functional importance of these arteries. (
  • Among non-amniote groups, coronary arteries are morphologically diverse and are frequently lost in fishes, indicating that they are less important in these animals (see Grant and Regnier, 1926 ). (
  • These differences suggest that coronary arteries are essential for survival in amniotes. (
  • However, what morphological changes have occurred in the evolution of amniote coronary arteries is unknown. (
  • In amniotes, the branching point of the coronary arteries is located at the aortic sinuses close to the ventricle. (
  • Myocardial bridges were found in 57,14% of hearts the studied mean widths value was 1,47 cm and usually the bridges were located in the ventral portions (30,76%), and dorsal (26,92%) on the left and right coronary arteries. (
  • Early generation sirolimus-eluting stents (SES) lead the pack for percutaneous coronary intervention (PCI) in small coronary arteries, according to a network meta-analysis. (
  • Early-generation SES yielded the most favorable angiographic and clinical outcomes for the treatment of stenoses in small coronary arteries," the investigators concluded. (
  • Windecker's analysis included 19 trials and 5,072 patients who received PCI for CAD in small coronary arteries . (
  • Carotid stenosis is common, especially in patients with vascular risk factors or with coexistent pathology of coronary or peripheral arteries [ 1 , 2 ]. (
  • Medial calcification is unusual in the coronary arteries and therefore any detectable coronary calcification is taken to reflect calcium within intimal atherosclerotic lesions. (
  • Necropsy studies have shown that the amount of intimal calcium in the coronary arteries is related closely to the amount of plaque. (
  • Most heart attacks are caused by a blood clot that blocks one of the coronary arteries. (
  • The coronary arteries bring blood and oxygen to the heart. (
  • Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. (
  • One is that their hearts are smaller, and they tend to have small vessel disease instead of blockages in the larger coronary arteries. (
  • When the procedure was finished, Dr. Henry had inserted six stents, all at different locations in Jack's coronary arteries. (
  • 2. Subjects with coronary artery disease who have symptoms of angina pectoris and evidence of ischemia or myocardial viability in the area innervated by the coronary arteries where the CTO is located. (
  • Some cardiovascular diseases include coronary artery disease (where the arteries to the heart are blocked or narrowed), congestive heart failure (where the heart doesn't pump as efficiently as it should), and heart rhythm problems. (
  • Atherosclerosis occurs when plaque builds up inside the arteries, the blood vessels that carry oxygen-rich blood throughout your body. (
  • When atherosclerosis occurs in the arteries that supply blood to the heart, it is called coronary artery disease. (
  • Depending on the degree of blockage in your arteries, your doctor or cardiologist may recommend prescription medications, in addition to healthy lifestyle habits, to reduce the effects of coronary artery disease. (
  • Normally, deoxygenated blood from all over your body enters the right atrium and flows into the right ventricle, where it's pumped through large blood vessels (pulmonary arteries) to your lungs. (
  • The left circumflex coronary artery of dogs was perfused with arterial blood at constant flow, and coronary perfusion pressure was measured. (
  • 3] On occasion, the right ventricle can be subjected to infarction from occlusion of the left circumflex coronary artery. (
  • ECG, blood test, coronary angiography to visualize the vessels). (
  • Coronary angiography was performed only if symptoms and/or objective evidence of ischemia recurred. (
  • Progression of native vessel disease and graft patency were determined by comparison of pre- and postoperative angiography.A total of 3816 native vessels and 1242 bypass grafts were analyzed, of which 386 moderate preoperative lesions were identified, 323 of which were grafted. (
  • To determine the best combination of parameters that would improve the diagnostic performance of exercise testing, coronary angiography plus exercise testing were done on 112 patients with angina pectoris and normal electrocardiogram. (
  • 5. Angiography of the target CTO showed high density along the vessel, which is considered calcified lesion. (
  • On studying the number of vessels affected among patients with abnormal angiography it was noted that one vessel affection was found mainly among HCV-negative patients (59.3% com- pared to 17.4% among HCV-negative and -positive patients). (
  • Coronary angiography uses dye and X-rays to determine how blood is flowing through the heart. (
  • Resistive vessel function in coronary artery disease. (
  • To determine the factors that influence the presence of collateral vessels during coronary occlusion, we performed standardized contrast injection of the contralateral coronary artery in 58 consecutive patients, without previous myocardial infarction, undergoing percutaneous transluminal coronary angioplasty for 1-vessel disease (left anterior descending artery in 45, right coronary artery: in 10 and left circumflex artery in 3). (
  • Coronary artery disease is a condition in which the blood supply to the heart muscle is partially or completely blocked. (
  • Coronary artery disease was once widely thought to be a man's disease. (
  • After menopause, coronary artery disease becomes more common among women. (
  • Among people aged 75 and older, a higher proportion of the people who have coronary artery disease are women because women live longer. (
  • In high-income countries, coronary artery disease is the leading cause of death in both men and women, accounting for about one third of all deaths. (
  • Coronary artery disease affects people of all races, but the incidence is extremely high among people of African ancestry. (
  • We studied 350 patients with single-vessel coronary artery disease who underwent a single-site balloon dilation. (
  • Coronary microvascular disease is popularly known as small vessel heart disease . (
  • The risk of coronary microvascular disease or small vessel heart disease is higher in case of women and those individuals who have high blood pressure or diabetes. (
  • Although it is hard to diagnose this disease but once diagnosed, coronary microvascular disease or small vessel heart disease can be fully treated. (
  • Women are more prone to coronary microvascular disease or small vessel heart disease than men. (
  • Signs and symptoms of coronary microvascular disease or small vessel heart disease are slightly different from that seen in traditional coronary artery disease (CAD). (
  • The common symptoms of coronary artery disease are feeling pressure or squeezing in the chest, angina (chest pain), excessive sweating, shortness of breath, pain in shoulder and arms etc. (
  • The women with coronary microvascular disease or small vessel heart disease may show some identical symptoms like sleep problems, lack of energy, fatigue (tiredness), shortness of breath etc. (
  • The symptoms of coronary microvascular disease or small vessel heart disease are often noticed during daily activities especially under severe mental stress. (
  • Traditional coronary artery disease (CAD) will always lead to blockage in heart which is not always the case with coronary microvascular disease. (
  • Thus it falls in the category of non-obstructive coronary artery disease. (
  • The risk factors for the coronary microvascular disease or small vessel heart disease are almost similar to that of coronary artery disease like diabetes, high blood pressure, insulin resistance, unhealthy cholesterol levels, lack of physical activity, age, smoking , overweight and obesity , and family history of early heart disease. (
  • It is not easy to detect Coronary microvascular disease straight away. (
  • Once diagnosed with coronary microvascular disease or small vessel heart disease, the patients must ensure that it does not get worse making necessary changes in lifestyle and taking proper medicines, and regular medical care. (
  • Women have higher possibilities of encountering with coronary microvascular disease or small vessel heart disease as factors like smoking, high blood pressure, diabetes can cause more harm in case of women. (
  • Single vessel coronary artery disease. (
  • Dive into the research topics of 'Single vessel coronary artery disease. (
  • IMSEAR at SEARO: Restenosis after successful coronary angioplasty in single vessel disease. (
  • One hundred and ninety five patients who underwent successful percutaneous transluminal coronary angioplasty (PTCA) for single vessel disease and have been followed up for more than 6 months are being reported. (
  • Autopsy studies [ 1 , 2 ] and x-ray CT in older subjects with suspected disease [ 3 ] have demonstrated increasing coronary vessel thickness with age. (
  • Aims Coronary artery bypass grafting (CABG) has been considered the standard of care for patients with three-vessel disease (3VD), but long-term comparative results from randomized trials of CABG vs. percutaneous coronary intervention (PCI) using drug-eluting stents (DES) remain limited. (
  • In the coronary blood vessels , IVL modifies arterial calcium and enables percutaneous coronary interventions to be performed in a safe and consistent manner, and in the peripheral blood vessels , IVL can be used as a standalone therapy in the treatment of calcified plaque in patients with peripheral artery disease (PAD). (
  • Due to the success of the Disrupt CAD and Disrupt PAD clinical trials, IVL is now FDA-approved in the United States for use in both patients with coronary artery disease (CAD) and PAD. (
  • Evidently there is collateral circulation, which in man under normal conditions is not of great physiological significance, although in the presence of coronary artery disease it may have a considerable functional value [4]. (
  • Long Term Outcome Of Hybrid Revascularization In Multi Vessels Coronary Artery Disease In A Single Institution Study. (
  • There is increasing interest in the hybrid coronary artery revascularization procedure combining the long term benefit of the left internal mammary graft to the LAD with PCI to the non-LAD vessels aiming to achieve complete revascularization for multi-vessel coronary disease. (
  • The patient had a severe form of aortic valve disease along with coronary artery stenosis. (
  • Ventricular fibrillation (VF) occurs in a variety of clinical situations but is most often associated with coronary artery disease (CAD). (
  • Coronary artery disease (CAD) is the single most common etiologic factor predisposing patients to ventricular fibrillation (VF). (
  • An analysis of progression of native vessel disease during a randomized trial of conduits. (
  • We investigated whether grafting such vessels is warranted based on angiographic evidence of disease progression.Of 619 patients who underwent on-pump coronary artery bypass grafting in an ongoing, randomized radial artery trial, 405 have at least 1 follow-up angiogram at a mean of 6.2 ± 3.1 years (range, 0-14 years) after surgery. (
  • Placement of a graft for a moderate lesion was associated with significantly greater incidence of disease progression, most marked in the right coronary territory.The greater risk of progression of left-sided moderate lesions, and high graft patency rates when bypassed, suggests that the balance of clinical judgment lies in favor of grafting moderate left-sided lesions. (
  • A 60-year-old male nonhypertensive, nondiabetic, previously diagnosed coronary artery disease (CAD) patient came to our hospital with complaints of severe chest pain suggestive of unstable angina. (
  • Coronary artery disease was present in nine workers, cerebrovascular accident in one, and aortic stenosis in one. (
  • Because it measures costs and outcomes in monetary (not disease-specific) terms, CBA enables comparison of disparate technologies, e.g., coronary artery bypass graft surgery and screening for breast cancer. (
  • A notable undesirable effect is coronary artery constriction, which may dispose patients with coronary artery disease to cardiac ischemia. (
  • She had severe three-vessel coronary disease. (
  • The most common symptom of coronary artery disease is angina. (
  • Behavioural risk factors are responsible for about 80% of coronary heart disease and stroke. (
  • A growing number of patients, particularly those with advanced, chronic coronary artery disease, experience symptoms of angina that are refractory to treatment with β-blockers, calcium-channel blockers, and long-acting nitrates, despite revascularization. (
  • These effects are presumed to accelerate the progression of atheromatous disease, particularly within the coronary or cerebral vasculature. (
  • The exercise electrocardiogram (ECG) is used in the evaluation of symptomatic patients to predict the presence and extent of coronary artery disease (CAD) [1,2]. (
  • In any case, they cautioned, "BMS and balloon angioplasty had the worst ranking position for all study outcomes and therefore cannot be considered as effective alternatives for patients undergoing PCI of small vessel disease. (
  • The concept of revascularization delivering an antiproliferative drug via nonstent-based platforms had been attractive, but "the results of the present study indicate that DES -- particularly SES -- are superior to DCB for the treatment of small vessel coronary artery disease by providing superior angiographic and clinical outcomes," Windecker's group concluded. (
  • Atherosclerosis is a progressive disease with periods of stability and sometimes reparation, which begins with endothelial damage of the vessel wall already in infancy and adolescence. (
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (
  • Case-patient 1 was a 60-year-old man with a history of coronary disease who required a coronary artery bypass graft because of 3-vessel coronary disease. (
  • Cigarette smoking is associated with stroke and coronary heart disease, it damages blood vessels and makes your heart beat faster, and can cause blockages that reduce blood flow to your legs and skin. (
  • Methods In a population-based study of 570 randomly selected asymptomatic men aged 40-49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD). (
  • A histochemical, cytophotometric and morphometric study of hypothalamic microcirculatory vessels was conducted in 2 samples: 50 sudden cardiac deaths from coronary heart disease and 50 cardiac deaths from clinical myocardial infarction that were not sudden. (
  • Angina is not a condition, instead, it is a symptom of coronary artery disease or clogged blood vessels that go to and from the heart. (
  • Angina is a common warning sign of coronary artery disease, a condition that can be life-threatening. (
  • Coronary heart disease does not always have obvious symptoms. (
  • Coronary heart disease is caused by a build-up of fatty substances in the blood vessels supplying the heart. (
  • The main treatments for coronary heart disease are healthy lifestyle changes and medicines. (
  • You can reduce your risk of getting coronary heart disease by making simple lifestyle changes, such as being active and having a healthy diet. (
  • Coronary heart disease is a common but serious condition where the blood vessels supplying the heart are narrowed or blocked. (
  • The higher the HDL value, the lower the risk of coronary artery disease. (
  • Certain antioxidant vitamins may lower risk for coronary heart disease diseases of the heart and vessels, which summarizes as coronary heart disease, are widely used in the Western world. (
  • I25.119 is a valid billable ICD-10 diagnosis code for Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris . (
  • According to a recent report, cardiovascular disease claims more lives worldwide than any other disorder.1 Diseases of the heart and blood vessels, including coronary artery disease, are responsible for more than 4 million deaths in Europe each year2 and almost one-third of all deaths worldwide. (
  • Cardiovascular diseases (CVDs) are disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions. (
  • CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions. (
  • Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. (
  • Some evidence indicates arginine may reduce symptoms of angina and coronary disease. (
  • Coronary artery disease (CAD) is one of the leading causes of death worldwide. (
  • The aim of this study was to explore the association between hepatitis C viral infection and coronary artery disease. (
  • A consecutive sample of 50 patients with abnormal angiographic findings was matched with another 50 consecutive patients with normal angiographic findings regarding age, sex, and major risk factors for coronary artery disease (diabetes mellitus, hypertension and smoking). (
  • The possible association between HCV positivity and extension of coronary artery disease may refer to the role of HCV in coronary artery disease pathology. (
  • El Amroosy M. Association between coronary artery disease and hepatitis C virus seropositivity. (
  • Heart health supplements Ozone Park, USA can improve cardiac function in patients with coronary heart disease and provides improvement in blood flow. (
  • Coronary artery disease (otherwise known as CAD) is the most common type of heart disease in the United States and the leading cause of death among American men and women. (
  • A number of risk factors contribute to the development of coronary artery disease. (
  • If you have coronary artery disease, it's vital to take control of your condition and improve your heart health now. (
  • Pain and tightness in the chest are common symptoms of coronary artery disease, but many prescription medications can offer relief. (
  • The best results are in the younger patients with a low to intermediate risk of coronary artery disease with a low pre-test probability of disease. (
  • This 56-years old man came with a history of hyperlipedemia and a family history of coronary artery disease. (
  • Included is the surgical care of coronary artery disease, cancers of the lung, esophagus and chest wall, abnormalities of the trachea, abnormalities of the great vessels and heart valves, congenital anomalies, tumors of the mediastinum and diseases of the diaphragm. (
  • This is also the leading cause of hypertension but the eyes, causes of conditions and death, coronary artery disease. (
  • 5) Behavior Questionnaire elicited data on behavior which may be associated with coronary heart disease for examined persons ages 25-74. (
  • In the United States, the most common type of heart disease is coronary artery disease (CAD, or ischemic heart disease), which can lead to heart attack. (
  • This data can be used to identify trends in the mortality of heart disease (heart attack, coronary heart disease). (
  • These indicators include data on the crude and age-adjusted rate of coronary heart disease and the prevalence of adults ever diagnosed with stroke. (
  • presence of associated 50% stenosis of other vessels. (
  • In an autopsy study of 169 cases of coronary death, approximately 61% of patients had died suddenly of presumed VF, and another 15% of cases showed more than 75% stenosis in three or four vessels as well as similar severe lesions in at least two vessels. (
  • Percent diameter stenosis in each major native vessel was reported by 3 cardiac specialists and classified as either moderate (40%-69%) or severe (≥70%) stenosis. (
  • After stabilization, coronary angiogram (CAG) was performed that revealed multiple severe stenosis in both left coronary artery including the left anterior descending (LAD) and left circumflex artery (LCx) and in their branches (Proximal LAD discrete 60% stenosis, Obutse marginal branch - 99% and LCx (beyond OM1)-100%) [Figure 1]. (
  • The Authors' Reply: Which Functional Imaging Should We Refer to When Encountering an Anatomically Intermediate Coronary Stenosis? (
  • In most cases, carotid stenosis is the result of atherosclerotic changes of the vessel wall. (
  • The right coronary artery and the left coronary artery, which branch off the aorta just after it leaves the heart, deliver oxygen-rich blood to the heart muscle. (
  • The right coronary artery branches into the marginal artery and the posterior interventricular artery, located on the back surface of the heart. (
  • Double right coronary artery is a very rare coronary anomaly. (
  • Various nomenclature or keywords "double right coronary artery," "duplicated right coronary artery," "dual right coronary artery," and "split right coronary artery" are used. (
  • The posterior descending branch of the right coronary artery usually supplies the inferior wall of the right ventricle. (
  • The acute marginal branches of the right coronary artery supply the anterior wall of the right ventricle, and the conus branch supplies the infundibulum of the right ventricle. (
  • A direct correlation exists between the anatomic site of right coronary artery occlusion and the extent of right ventricular infarction. (
  • Studies have demonstrated that more proximal right coronary artery occlusions result in larger right ventricular infarctions. (
  • More recently, vascular abnormalities, including coronary aneurysm without atherosclerosis, and brain MRI abnormalities, including focal hyperintensities and Chiari I malformations, have been described. (
  • Objective This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese). (
  • The last few years have seen a surge of interest in the measurement of coronary artery calcification to predict and monitor the presence of coronary atherosclerosis. (
  • Quickview {"id":2655394824277,"title":"A-3 VENTFORT - BLOOD VESSELS PEPTIDE 20 CAPSULES","handle":"a-3-ventfort-blood-vessels-peptide-20-capsules","description":"\u003ch5\u003eDescription\u003c\/h5\u003e\n\u003ch2\u003eVentfort® - The blood vessels peptide bio-regulator\u003c\/h2\u003e\n\u003cp\u003eVentfort is a dietary supplement with natural aorta peptides.With age, the blood vessels become more rigid and are affected by atherosclerosis. (
  • A heart attack - or myocardial infarction (MI) - happens when a problem somewhere in the body reduces or blocks blood flow to a coronary artery. (
  • Describe the relevance of the findings on the effect of atorvastatin on the risk for myocardial infarction after percutaneous coronary intervention to clinicians in the care of their patients with acute coronary syndromes. (
  • Unstable Angina) Acute coronary syndromes result from a sudden blockage in a coronary artery. (
  • Is C-reactive protein associated with the pancoronary process in acute coronary syndrome? (
  • Inform clinicians of the latest medical information on the use of atorvastatin before percutaneous coronary intervention procedures in patients with acute coronary syndromes. (
  • Revascularization procedures include coronary artery bypass grafting and percutaneous coronary intervention. (
  • The cardiac veins collect blood containing waste products from the heart muscle and empty it into a large vein on the back surface of the heart called the coronary sinus, which returns the blood to the right atrium. (
  • Conclusion: The decrease of the catecholaminergic innervation of heart and coronary vessels of old rats can be in close relationships to the poor cardiac and/or coronary functions observed in old animals. (
  • MRI is also able to quantify the blood volume flow in the great vessels, the shunt volumes between the circularity sides and the function of the cardiac valves. (
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (
  • Therefore, if we use a graft that irrigates two or more coronary branches, it obviously increases the surface area and, consequently, increases the flow by this graft. (
  • Whether to graft a moderately stenosed coronary vessel remains debatable. (
  • He was stabilized by standard medical management of nitrates, antiplateletes, diuretics, statins, and prepared for coronary artery bypass graft surgery. (
  • The presence of collateral vessels during coronary occlusion, defined as partial or complete epicardial opacification by collateral vessels of the vessel dilated, was related to clinical, angiographic and electrocardiographic parameters. (
  • By combining lesion severity with the duration of angina, collateral vessels during coronary occlusion were particularly related to a lesion severity greater than or equal to 70% and duration of angina greater than or equal to 3 months (p less than 0.001). (
  • Furthermore, the presence of collateral vessels was associated with an absence of ST-segment shift (greater than or equal to 1 mm) during 1 minute of coronary occlusion (p less than 0.001). (
  • Stents are used for many conditions involving vasoconstriction or occlusion of a blood vessel. (
  • New treatment principles are emerging in current practice, such as metabolic modulation, therapeutic angiogenesis, and novel interventional techniques (coronary in-flow redistribution and approaches to chronic total occlusion). (
  • Figure 4: Successful percutaneous coronary intervention for chronic total occlusion is associated with reduced angina frequency. (
  • If the occlusion occurs before the right ventricular marginal branches and if collateral blood flow from the left anterior descending coronary artery is absent, then the size of infarction is generally greater. (
  • chronic total occlusion of coronary artery ( I25.82 ) exposure to environmental tobacco smoke ( Z77.22 ) history of tobacco dependence ( Z87.891 ) occupational exposure to environmental tobacco smoke ( Z57.31 ) tobacco dependence ( F17 . (
  • Regarding anatomy, the characteristic of coronary irrigation is to be terminal, i.e., each arterial branch irrigates a single territory. (
  • Arterial and vein grafts to left-sided moderately stenosed vessels had excellent patency (83% and 77% at 8 years, respectively), which was not matched by right-sided grafts (P = .051). (
  • Functional disturbance of laminar blood flow, particularly in arterial junctions, promotes the accumulation of LDL and consecutively lead to remodeling of the vessel wall. (
  • Although IVUS is highly sensitive and specific for calcification, it is invasive, non-quantitative, and only visualises a limited portion of the coronary tree. (
  • In most of his vessels (Figs. 2, 3), the LAD can be seen to be normal despite the dense calcification. (
  • Coronary artery anomalies (CAAs) are assorted group of congenital disorder whose nomenclature, manifestations, and pathophysiological mechanisms are highly inconsistent. (
  • Coronary artery anomalies (CAAs) are the second most common cause of sudden death in older children and young adults in the absence of additional heart abnormalities after hypertrophic cardiomyopathy. (
  • Blood Supply of the Heart The heart and blood vessels constitute the cardiovascular (circulatory) system. (
  • Cardiovascular diseases affect the heart and blood vessels. (
  • In this seminar we tackle the problem of automatic characterization of human coronary vessel in Intravascular Ultrasound (IVUS) image modality. (
  • Between January 2000 to September 2016, a total of 178 patients underwent hybrid coronary revascularization. (
  • Patients who will experience little benefit from coronary revascularization are also excluded. (
  • Surgical correction of underlying disorders (eg, percutaneous coronary intervention, coronary artery bypass surgery) may also be indicated. (
  • Should all moderate coronary lesions be grafted during primary coronary bypass surgery? (
  • The cardiologists who reviewed Jack's angiogram told him he should prepare for coronary bypass surgery. (
  • 16. Subjects who are not candidates for coronary bypass surgery. (
  • The large study group and the fact that the same optimal values for diagnostic accuracy of the various quantitative angiographic variables were obtained for the prediction of two different markers of ischemia suggests that these values reflect the lesion severity or increase in lesion severity in major epicardial vessels at which coronary flow reserve is unable to meet myocardial demands. (
  • [ 7 ] No single coronary artery lesion is associated with an increased risk for VF. (
  • In the right coronary system, however, a lesion is likely to remain moderate if left ungrafted and, with a low risk of progression, it may be reasonable to leave these vessels undisturbed. (
  • 8. In addition to the target lesion, there must be up to one non-target lesion to be treated and it is located on a different epicardial vessel than the target lesion. (
  • 1. Target lesion must be located within a stent (bare metal or drug eluting) placed in a native epicardial coronary vessel with visually estimated nominal vessel diameter of =2.0mm and =3.5mm. (
  • The aim of this study was to determine which quantitative angiographic variable best describes functional status 6 months after coronary balloon angioplasty. (
  • Angioplasty is a procedure to open narrowed or blocked blood vessels that supply blood to the heart. (
  • Limitation of coronary perfusion of different degree induces inhomogeneous changes in resistance of vessels in the hypoperfusing zone: an adequate dilatory regulatory reaction may be followed by an increase in resistance of the coronary vessels. (
  • An active component of diastolic coronary resistance used to analyze vascular reactions, rate and character of changes in resistance under conditions of coronary perfusion as well as histological and electron-microscopic estimation of the vascular wall state testify to reversibility and active character of the observed changes in coronary resistance including its increase. (
  • This increase is pathogenetically significant as it may induce further development of the coronary perfusion disorder. (
  • In addition the reduction in aortic compliance may result in a decrease in diastolic coronary perfusion, as this is dependent on the recoil of the aorta which has been stretched during systole. (
  • 20. Zaremba M, Górska R, Suwalski P, Kowalski J. Evaluation of the incidence of periodontitis-associated bacteria in the atherosclerotic plaque of coronary blood vessels. (
  • RePub, Erasmus University Repository: Which angiographic variable best describes functional status 6 months after successful single-vessel coronary balloon angiopasty? (
  • A stent is used to keep open and dilate vessels and hollow organs. (
  • In the beginning, a stent inserted coronary was simply an alloy of stainless steel. (
  • The idea is that the vessel only needs to be supported for a while, and a stent is a foreign body.These so-called bio-stents are available in different types, and development is still ongoing. (
  • A coronary artery stent is a small, metal mesh tube that expands inside a coronary artery. (
  • 15. Restenosis is present in a stent previously deployed in the left main coronary artery. (
  • This is because the most effective treatment for a heart attack is often coronary artery catheterization and possible stent placement . (
  • Annual operator volume among patients treated using percutaneous coronary interventions with rotational atherectomy and procedural outcomes : analysis based on a large national registry. (
  • The presence of associated subcritical lesions of other vessels did not affect clinical picture. (
  • A higher surgical risk was noted in proximal lesions, in the presence of previous anterior infarction, of associated subcritical lesions of other vessels. (
  • Although questions remain regarding IVL's high cost and performance compared directly to other technologies such as atherectomy , its ease of use, speed, and safety makes its future extremely promising for the treatment of complex, heavily calcified lesions in both peripheral and coronary vessels . (
  • 4. Non-clinical investigation, percutaneous intervention for lesions in a non-target vessel is allowed if done =90 days prior to or planned to be done 6 months after the index procedure. (
  • 5. Non-clinical investigation, percutaneous intervention for lesions in the target vessel is allowed if planned to be done 6 months after the index procedure. (
  • Alfonso F, et al "Optimal coronary interventions in small vessels: is size all that matters? (
  • Freitas1 coronary interventions (PCI) in octogenarians are increasingly indicated. (
  • 2. Target CTO is located in a native coronary artery with a reference vessel diameter of = 2.5 mm. (
  • The blood flow can no longer flow properly due to the narrowing and blockage of the vessels, which can result in a stroke and a heart attack. (
  • A stroke (or brain attack) involves brain damage from a blood vessel in the brain bursting or the occurrence of a blood supply blockage affecting a portion of the brain. (
  • Coronary responses to adrenergic stimuli were determined in the intact beating heart before and after administration of practolol, 4-(2-hydroxy-3-isopropylaminoproproxy) acetanilide, which in low doses blocks myocardial but not vascular beta receptors. (
  • In cases of sudden coronary death, three patterns of microcirculatory changes were identified that differed with respect to the quantity of functionally-inactive capillaries, the markedness of edema in hypothalamic tissues and hypothalamic content of vascular mast cells. (
  • The Swedish Heart and Vascular Institute is seeking an Interventional Cardiologist for its complex coronary interventional program. (
  • This can affect your small vessels even worse by making them even narrower during emotional stress or active mode causing symptoms similar to heart attack or angina . (
  • This ratio has been shown to be one of the best predictors of coronary risk, with the lower the ratio the better. (
  • Terpenoids dilate blood vessels and reduce the stickiness of platelets, resulting in improved circulation. (
  • Also known as ARBs, these are heart medications that block the angiotensin II hormone and widen or dilate blood vessels to improve blood flow. (
  • 4 patients required coronary artery bypass grafting (CABG). (
  • Coronary artery bypass grafting (CABG) - Surgeons use a piece of healthy blood vessel, usually from the leg or wrist, to bypass a blocked portion of coronary artery that is reducing blood flow to the heart. (
  • Background: Age-related changes of catecholaminergic nerve fibers supplying the myocardium and the coronary vessels were studied in adult and in old rats. (
  • Methods: Samples of myocardium and/or coronary vessels were studied by means of glyoxylic acid induced fluorescence, aldehyde-induced fluorescence, and neuropeptide Y immunoreactivity. (
  • Angina is a specific type of pain in the chest caused by inadequate blood flow through the blood vessels (coronary vessels) of the heart muscle (myocardium). (
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (
  • With complementary MRA examination, the accompanying abnormalities of thoracic vessels can also be revealed. (
  • Not all capillaries are open at the same time, because the sphincter capillaries exert a regulatory function which represents about 95% of the resistance of the system between the "coronary ostium to the coronary sinus [4]. (
  • It is clear, therefore, that despite great changes in myocardial oxygen consumption, oxygen saturation in the coronary sinus remained essentially stable, i.e., 4-5% vol." [5]. (
  • Coronary Microvasculature: Are the Small and the Mighty Cross-Talking With the Epicardial Vessels? (
  • A Novel Approach to Calcium Destruction in Coronary and Peripheral Blood Vessels: Intravascular Lithotripsy. (
  • It is normally seen that women with symptoms of heart problems are more likely to be diagnosed with coronary related artery diseases. (