Spasm of the large- or medium-sized coronary arteries.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The circulation of blood through the CORONARY VESSELS of the HEART.
Drugs used to cause dilation of the blood vessels.
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Narrowing or constriction of a coronary artery.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Radiography of the vascular system of the brain after injection of a contrast medium.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
Pressure, burning, or numbness in the chest.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)

Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. (1/422)

In the present study we used a bioassay to study the effects of peroxynitrite (ONOO-) on angiotensin II (A-II)-triggered tension in isolated bovine coronary arteries in order to show the consequences of the previously reported PGI2-synthase inhibition by ONOO- in this model. The following results were obtained: 1. 1 micromol L(-1) ONOO- impaired A-II-induced vasorelaxation and caused a second long lasting constriction phase. Indomethacin (10(-5)M) prevented both effects. U51605, a dual blocker of PGI2-synthase and thromboxane (TX)A2-synthase mimicked the effects of ONOO-. 2. The selective TXA2/prostaglandin endoperoxide (PGH2) receptor antagonist SQ29548 antagonized the second vasoconstriction phase after ONOO- -treatment. Since a generation of TXA2 and 8-iso-prostaglandin F2alpha could be excluded a direct action of unmetabolized PGH2 on the TXA2/PGH2 receptor was postulated. 3. ONOO- dose-dependently inhibited the conversion of 14C-PGH2 into 6-keto-PGF1alpha in isolated bovine coronary arteries with an IC50-value of 100 nM. 4. Immunoprecipitation of 3-nitrotyrosine-containing proteins with a monoclonal antibody revealed PGI2-synthase as the only nitrated protein in bovine coronary arteries treated with 1 micromol 1(-1) ONOO-. 5. Using immunohistochemistry a co-localization of PGI2-synthase and nitrotyrosine-containing proteins was clearly visible in both endothelial and vascular smooth muscle cells. We concluded that ONOO- not only eliminated the vasodilatory, growth-inhibiting, antithrombotic and antiadhesive effects of PGI2 but also allowed and promoted an action of the potent vasoconstrictor, prothrombotic agent, growth promoter, and leukocyte adherer, PGH2.  (+info)

Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. (2/422)

Japanese investigators have provided a substantial contribution in the understanding of coronary vasomotor reactivity. On occasions, their findings have been at variance with those undertaken on caucasian patients, raising speculation that vasomotor differences between races may exist. In a comparative review of the published literature, we evaluated the vasoreactive differences among Japanese and caucasian patients with variant angina or myocardial infarction. In variant angina, Japanese patients appear to have diffusely hyperreactive coronary arteries compared with caucasian people, manifested by their segmental rather than focal spasm, hyperreactive nonspastic vessels and multivessel spasm. These differences may reflect the increased basal tone among Japanese variant angina patients and may relate to controversial differences in endothelial nitric oxide production or autonomic nervous system activity. Provocative vasomotor studies of Japanese patients with a recent myocardial infarction report a higher incidence of inducible spasm than caucasian studies, an observation recently supported by a controlled study. Furthermore, the hyperreactivity was diffuse, occurring in both non-infarct- and infarct-related vessels. These observations support the existence of racial coronary vasomotor reactivity differences but require confirmation in further prospectively conducted studies.  (+info)

Intraoperative spasm of coronary and peripheral artery--a case occurring after tourniquet deflation during sevoflurane anesthesia. (3/422)

A 68-yr-old man with a 9-yr history of hypertension presented for hemiglossectomy, segmental resection of the mandible, and the radial forearm free flap grafting. Intraoperatively, facial artery spasm was observed during microvascular suturing of the radial artery to the facial artery. Simultaneously, systolic blood pressure decreased from 100 to 80 torr and the ST segment elevated to 15 mm from the base line. The possible mechanisms responsible for vasospasm in coronary as well as in peripheral arteries under sevoflurane anesthesia are discussed.  (+info)

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. (4/422)

BACKGROUND: Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases in general. However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm. METHODS AND RESULTS: We searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm. In this study, we demonstrate the existence of 3 linked mutations in the 5'-flanking region of the eNOS gene (T-786-->C, A-922-->G, and T-1468-->A). The incidence of the mutations was significantly greater in patients with coronary spasm than in the control group (P<0.0001). Multiple logistic regression analysis with forward stepwise selection using the environmental risk factors and the eNOS gene variant revealed that the most predictive independent risk factor for coronary spasm was the mutant allele (P<0.0001). As assessed by luciferase reporter gene assays, the T-786-->C mutation resulted in a significant reduction in eNOS gene promoter activity (P<0.05), whereas neither the A-922-->G nor the T-1468-->A mutation had any affect. CONCLUSIONS: Taken together, these findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.  (+info)

A case of vasospastic angina presenting Brugada-type ECG abnormalities. (5/422)

An electrophysiological study and a provocative test of coronary artery spasm was attempted in a 68-year-old man who was having syncopal attacks and chest pain. His electrocardiogram had the characteristics of Brugada syndrome and ventricular fibrillation (VF) was induced by programmed electrical stimulation. ST-segment elevation became exaggerated by procainamide, which could not prevent the induction of VF. Coronary angiography revealed no stenotic lesions, and spasm in the left coronary artery was induced by intracoronary administration of acetylcholine with similar chest pain to that experienced before. Under treatment with diltiazem and flecainide, which suppressed the induction of VF, the patient experienced no recurrence of symptoms despite persistent ST-segment elevation. No previous reports have described coronary spasm associated with Brugada-type ECG abnormalities, and patients with syncope should be evaluated carefully.  (+info)

Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. (6/422)

The role of peroxynitrite in hypoxia-reoxygenation-induced coronary vasospasm was investigated in isolated bovine coronary arteries. Hypoxia-reoxygenation selectively blunted prostacyclin (PGI2)-dependent vasorelaxation and elicited a sustained vasoconstriction that was blocked by a cyclooxygenase inhibitor, indomethacin, and SQ29548, a thromboxane (Tx)A2/prostaglandin H2 receptor antagonist, but not by CGS13080, a TxA2 synthase blocker. The inactivation of PGI2 synthase, as evidenced by suppressed 6-keto-PGF1 alpha release and a decreased conversion of 14C-prostaglandin H2 into 6-keto-PGF1 alpha, was paralleled by an increased nitration in both vascular endothelium and smooth muscle of hypoxia-reoxygenation-exposed vessels. The administration of the nitric oxide (NO) synthase inhibitors as well as polyethylene-glycolated superoxide dismutase abolished the vasospasm by preventing the inactivation and nitration of PGI2 synthase, suggesting that peroxynitrite was implicated. Moreover, concomitant administration to the organ baths of the two precursors of peroxynitrite, superoxide, and NO mimicked the effects of hypoxia-reoxygenation, although none of them were effective when given separately. We conclude that hypoxia-reoxygenation elicits the formation of superoxide, which causes loss of the vasodilatory action of NO and at the same time yields peroxynitrite. Subsequently, peroxynitrite nitrates and inactivates PGI2 synthase, leaving unmetabolized prostaglandin H2, which causes vasospasm, platelet aggregation, and thrombus formation via the TxA2/prostaglandin H2 receptor.  (+info)

Transient severe mitral regurgitation complicating myocardial stunning due to coronary vasospasm. (7/422)

As in papillary muscle dysfunction complicating mitral prolapse, dyskinesis of the left ventricular wall underlying the papillary muscles has been shown to cause mitral regurgitation following myocardial infarction. Myocardial stunning has been experimentally evidenced to cause mitral regurgitation due to a wall motion abnormality, but it has not yet been clinically defined. We report a clinical case of transient severe mitral regurgitation complicating myocardial stunning caused by coronary vasospasm. Transient wall motion abnormality beneath the anterolateral papillary muscle was considered to be responsible for the mitral regurgitation.  (+info)

Prognostic significance of the pattern of multivessel spasm in patients with variant angina. (8/422)

Multivessel spasm in variant angina is believed to be a major prognostic factor. Three patterns of multivessel spasm have been detected: (1) spasm at different sites on different occasions (migratory spasm); (2) spasm sequentially affecting 2 different sites (sequential spasm); and (3) simultaneous spasm at more than 1 site (simultaneous spasm). The present study investigated the prognosis based on this factor for variant angina without fixed coronary stenosis and examined the influence of multivessel spasm on cardiac events. Twenty-six patients were diagnosed as having variant angina without fixed coronary stenosis using 12-lead 24-h ECG recording system and coronary cineangiography. These patients were followed up prospectively for 57.1+/-7.6 months. Of the 26 patients 13 had single-vessel spasm, 6 had migratory multivessel spasm angina, and 7 showed sequential and/or simultaneous multivessel spasm angina. The survival free of serious cardiac events and of all cardiac events was significantly lower for patients with sequential and/or simultaneous multivessel spasm than for those with migratory multivessel spasm (p<0.05, p<0.05), whereas for patients with migratory multivessel spasm the difference comparison with single-vessel spasm did not attain statistical significance (p = ns, p = ns). The results of this study suggest that there seems to be a high-risk subgroup (i.e., sequential and/or simultaneous multivessel spasm) among patients with variant angina.  (+info)

Genetic defects in the plasma membrane-associated sarcoglycan complex produce cardiomyopathy characterized by focal degeneration. The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies cardiomyopathy in this disorder. We evaluated the coro …
A discrepancy in the prevalence of coronary artery spasm exists across different ethnicities; in particular, the Japanese population has been reported to have a greater prevalence of this condition compared to Caucasians.[6] In fact, according to a study involving 2251 patients, coronary artery spasm has been estimated to account for approximately 41% of Japanese patients with angina pectoris who underwent angiography.[7] In addition, coronary spasm in Japanese is characterized by a diffuse hyperreactivity as manifested by a segmental pattern of spasm as well as by a multivessel involvement compared to focal involvement in other populations.[8] Moreover, following the administration of acetylcholine early after myocardial infarction for provocation of spasm, there has been three fold higher incidence of coronary spasm and a higher incidence of multivessel spasm among Japanese compared to Caucasians.[9] These findings highlight that the vasomotor reactivity of coronary artery is not homogeneous ...
We applaud the authors of Invasive Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease, 1 who demonstrated an occult coronary abnormality in more than three quarters of these patients. Identifying the underlying abnormality is especially important for potentially life-threatening conditions that are amenable to treatment such as coronary artery spasm. Coronary spasm is associated with myocardial infarction, arrhythmias, and sudden death yet is responsive to calcium channel blockers and nitrates. Surprisingly, as stated in the accompanying editorial,2 no patient had inducible spasm on acetylcholine provocation. This observation warrants closer scrutiny, particularly in relation to the acetylcholine provocation method used.. Intracoronary acetylcholine administration is used to assess the presence of coronary endothelial function and coronary spasm. Its use is ideal, given its very short half-life and established safety record.. Endothelial function studies ...
Symptoms are often very similar to pain associated with a more typical heart attack (development of a blockage in a heart artery). Symptoms often occur at rest, and at night. This is different than typical chest pain associated with heart artery blockages which is more typically experience during exertion.. ...
Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coronary spasm are discussed. ...
Coronary artery spasm is a cause of myocardial infarction with non-obstructive coronary arteries (MINOCA). Coronary spasm may occur spontaneously or in response to prescribed or illicit drugs. Myocardial injury and cardiomyopathies have been reported in association with the use of stimulants in children and adults with attention deficit hyperactivity disorder (ADHD).
In this issue of the Journal, Ong et al. (1) sought to determine the prevalence of coronary spasm in angina patients with angiographically normal coronary arteries. Of 304 patients with stable angina, 144 (47%) had normal coronary arteries or only minimal irregularities (,20% diameter reduction) at coronary angiography. Acetylcholine (ACH) testing was performed in 124 of the 144 patients and provoked coronary spasm in 77 (62%). Thirty-five patients (45%) with constrictor response presented with epicardial spasm (defined as a ≥75% diameter reduction with reproduction of the symptoms of the patient), and 42 patients (55%) presented with microvascular spasm (defined as ischemic electrocardiographic changes with symptom reproduction, but no epicardial spasm). Overall two-thirds of patients undergoing the ACH test presented with abnormal coronary artery vasomotion, a finding that also confirmed the presence of the ischemic syndrome.. The authors are to be congratulated for attempting to determine ...
Definitive diagnosis of coronary artery spasm often begins with a coronary angiogram that is performed with the expectation of finding atherosclerotic narrowing of a heart artery. Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. Two patients had coronary artery disease, and three had angiographically normal coronary arteries.. Acting fast at the first sign of heart attack symptoms can save your life and limit damage to your heart. Whether you have had a heart attack or not, if you feel depressed, tell your doctor. You can even have a silent heart attack, one with no symptoms. The symptoms of a heart attack can vary from person to person. To prevent a heart attack, you will most likely need to make lifestyle changes. The patient may need to be hospitalized to prevent a heart attack.. Without normal blood flow from the coronary arteries the heart becomes lack of oxygen and vital nutrients ...
1. Armstrong PW. Stable ischemic syndromes. In: Topol E. Textbook of Cardiovascular Medicine. Philadelphia: Lippincott Raven Publishers 1998. 2. Chatterjee T, Juelke PD, Thum P et al. Successful brachytherapy of coronary vasospasm. Heart 2003; 89(9): 25. 3. Cheng TO. Clinical implication of the hyperventilation test in the diagnosis of coronary artery spasm. Am J Cardiol 1997; 80: 1647. 4. Gersh BJ, Braunwald E, Bonow BO. Chronic coronary artery disease. In: Braunwald E. Heart Disease. A textbook of cardiovascular medicine. 6th ed. Philadelphia: WB Saunders 2001. 5. Halawa B, Salomon P. Activity of transmembrane calcium transport and levels of endothelin-1 in patients with variant angina. Pol Arch Med Wewn 2000; 104(2): 447-453. 6. Hirano Y, Ozasa Y, Yamamoto T et al. Hyperventilation and cold pressor stress echocardiography for noninvasive diagnosis of coronary artery spasm. J Am Soc Echocardiogr 2001; 14(6): 626-633. 7. Hirano Y, Ozasa Y, Yamamoto T et al. Diagnosis of vasospastic angina by ...
Coronary artery spasm (CAS) is an established cause for anginal chest pain, the cardinal symptom of myocardial ischaemia, in patients with angiographically unobstructed coronary arteries. Evidence from large clinical studies has revealed that about 50% of patients undergoing diagnostic coronary angiography for suspected coronary artery disease (CAD) had either normal or near
Exercise induced ST elevation in patients with previous myocardial infarction may simply indicate left ventricular wall asynergy. ST segment elevation without prior myocardial infarction is a rare condition and is commonly associated with critical coronary artery stenosis.1 Temporary ST segment elevation associated with chest pain is the hallmark of variant (Prinzmetal) angina, and is a consequence of severe coronary spasm. In a way that is not yet fully understood, exercise can induce coronary spasm in patients with variant angina, as demonstrated in small groups of patients subjected to supine bicycle exercise on the cardiac catheterisation table.2DSE is widely performed as a useful diagnostic tool in patients with known or suspected coronary artery disease. Through its inotropic and chronotropic effects, dobutamine increases the myocardial oxygen demand and may induce ischaemia and segmental wall motion abnormality in the presence of significant coronary artery disease. Myocardial ischaemia ...
There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of SUMAVEL® DosePro®. SUMAVEL® DosePro® may cause coronary artery vasospasm (Prinzmetals angina). These types of reactions have occurred in some patients without known CAD. For triptan-naïve patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administrating the first SUMAVEL® DosePro® dose in a medically-supervised setting and performing an electrocardiogram (ECG) immediately following SUMAVEL® DosePro® administration. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of SUMAVEL® DosePro®. Life-threatening arrhythmias have been reported within a few hours following the administration of 5-HT1 agonists. Discontinue SUMAVEL® DosePro® if these disturbances occur. Sensations of tightness, pain, pressure, and heaviness have been ...
The mean oral absolute online bioavailability of sales the maxalt retinal detachment symptoms Tablet is retin about online 45, and how to get retin a retin mean peak plasma concentrations (Cmax) are reached in sales approximately 1-1.5 hours (Tmax). Diagnosis Your health care provider may check the size of sales your sales prostate gland directly by putting a sales gloved finger in your rectum and feeling the back wall of the prostate. You can retin ask your pharmacist or sales doctor for information about maxalt that is written for health professionals. Have shortness of breath or chest pain. If there is evidence of CAD or coronary artery vasospasm, maxalt should not be retin administered see contraindications. This medication may be available under multiple brand names and/or in several different forms. You can place the order online, by mail, online by fax or toll-free over the telephone. Your health care provider will also order blood tests, and possibly a sales urine sample. Free Make Up ...
METHODS AND RESULTS Injury was induced by inflation of a balloon catheter 50 +/- 6% above baseline arterial diameter; dogs were followed for 2 hours before death. Epicardial coronary diameters at arteriography and extent of thrombus deposition at serial histological sections were analyzed in controls (n = 20) and in dogs pretreated with superoxide dismutase (SOD, a superoxide radical scavenger, n = 10); other dogs were pretreated with the hydrogen peroxide scavenger catalase (n = 8), the iron chelator deferoxamine (n = 6), or the hydroxyl radical scavenger 1,3-dimethyl-2-thiourea (n = 9). Angioplasty-induced injury was similar among groups. After angioplasty, control dogs exhibited localized and persistent vessel constriction, which was maximal at the initial 5 minutes (28.9 +/- 6.3% diameter decrease versus baseline). Corresponding arterial diameters of SOD-treated dogs were 24-69% larger (95% confidence interval, p less than 0.001) than controls at 5 minutes and, on average, 32% larger than ...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
Rev Esp Cardiol. 1997 Nov;50(11):808-11. [The placement of a Wiktor stent for the treat ment of vasospastic angina: a case report]. [Article in Spanish] Rodríguez Díez S1, Lázaro R, Ruiz Nodar JM, Enero J, Romero C, Gómez Recio M, Martínez Elbal L.
I am a 43 yo female who had a heart attack. My only risk factor is high bp due to kidney surgery as a child that has been controlled by meds. My EKG indicated damage and I had troponin levels of 6 and ...
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Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (|50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm a
Dr. Stern responded: Yes it can in some. If you are prone to coronary artery spasm, then emotional |a href=/topics/stress track_data={
In patients with angina and nonobstructive coronary-artery disease, coexistence of epicardial coronary spasm and increased microvascular resistance (IMR) is associated with worse outcomes, according to Japanese researchers.
Free Online Library: Coronary artery spasm--Clinical features, pathogenesis and treatment--.(Disease/Disorder overview) by Japan Academy Proceedings Series B: Physical and Biological Sciences; Agricultural industry Engineering and manufacturing Biological sciences Acetylcholine Aldehydes Angina pectoris Care and treatment Development and progression Genetic aspects Angiotensin II Coronary vasospasm Complications and side effects Endothelium Genetic polymorphisms Heart attack Ischemia Lipid peroxidation Myocardial ischemia Nitric oxide Smoking
Precautions. Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly: Safety and efficacy in patients , 65 yr not established. Cardiac events/vasoconstriction: Serious coronary events, though extremely rare, can occur after administration of 5-HT1 agonists. Administer first dose in health care providers office to patients at possible risk of unrecognized coronary disease. If symptoms consistent with angina occur, conduct ECG evaluation for ischemic changes. May cause coronary vasospasm in patients with history of CAD. Hepatic Function Impairment: Use with caution; use doses , 2.5 mg.. ...
how do you think this case could have played out differently? Think very few providers would get their cardiologists to bite on young, intoxicated male c/o chest pain with that initial ekg. Im sure most would write it off to early repol. maybe with serial ekgs or echo, but even then itd be a tough sell. Even more concerning is that we all see quite a few intoxicated and agitated young males/females in the department daily. Similar presentations. Feel as though we are so prone to write it off as demand ischemia, coronary vasospasm, trop leak etc.. in this population ...
how do you think this case could have played out differently? Think very few providers would get their cardiologists to bite on young, intoxicated male c/o chest pain with that initial ekg. Im sure most would write it off to early repol. maybe with serial ekgs or echo, but even then itd be a tough sell. Even more concerning is that we all see quite a few intoxicated and agitated young males/females in the department daily. Similar presentations. Feel as though we are so prone to write it off as demand ischemia, coronary vasospasm, trop leak etc.. in this population ...
PDE5 takes part in many physiological and pathological functions, therefore selective PDE5 inhibitors are potentially useful for a variety of pathologies. At the present, PDE5 inhibitors available on the market have been used for the treatment of erectile dysfunction but, at the same time, are in clinical trials investigating other pathologies such as pulmonary arterial hypertension, coronary vasospasm, benign prostatic hyperplasia etc. This review analyzes the PDE5 inhibitors currently in clinical use, the drugs in clinical trials and the most representative chemical classes published in literature in this last decade ...
Introduction Oral capecitabine is an oral prodrug of 5-fluorouracil that has been integrated into the management of multiple cancer types because of the convenience of administration and its efficacy...
Procardia belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, procardia is useful in treating and preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscles demand for oxygen, and further helps to prevent angina in patients with coronary artery disease ...
Procardia belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, procardia is useful in treating and preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscles demand for oxygen, and further helps to prevent angina in patients with coronary artery disease ...
Your doctor may prescribe medications such as nitroglycerin to relax the coronary arteries, calcium antagonists to guard against coronary artery spasm , or aspirin and other antiplatelet drugs to prevent blood clots in the area of the blockage. If you have a stent, you will have to take blood thinners (such as aspirin) inde?nitely. You will also take an antiplatelet such as clopidogrel at least one month after a bare-metal stent is placed in your artery and two or more years after a drug-eluting stent is placed in your artery. Because of the presence of the metal stent, you should not have magnetic resonance imaging (MRI) for at least 4 weeks with- out checking with your doctor ?rst. But you can go through a metal detector at an airport without a problem.. Restenosis. Restenosis (renarrowing or constriction) can occur in the same area of the blood vessel where your angioplasty was done, often within about 6 months of the original procedure. Although placement of a stent greatly reduces the ...
Jen Woodall wrote: , I strongly believe , that should be recognized in whatever way each person chooses. I always , acknowledge the date (well, close to it--cant always remember the exact , date) of my dx in some way. I know my diagnosis date EXACTLY, and I know exactly when my BGs started to go up, and I know when they went kablooie rapidly. I started to have problems in the summer of 1991; my BGs went kablooie starting on July 28, 1992, and I was officially diagnosed on Aug. 17, 1992 after landing in the hospital with a coronary artery spasm. Then they went back down again, and I was able to maintain on diet and exercise until the summer of 1993; in Sept. 1993, I went to the doc, and my BGs were once again rising rapidly, so she tried increasing doses and different sulfonylureas to no effect. I finally went on insulin on May 12, 1994, and THATs the date I celebrate! Like insulin gave me my life back, and I think THATs worth celebrating -- during my time on diet and orals, I was consistently ...
When plaque collects in the arteries, it can end up rupturing and cause blood clots to form. These blood clots further block the flow of oxygenated blood to the heart muscles. With time, this build up gets worse and prevents the flow to a point where the heart muscles are unable to get the necessary oxygenated blood ...
TY - JOUR. T1 - Diagnosis of coronary vasospasm in patients with clinical presentation of unstable angina pectoris using ergonovine echocardiography. AU - Song, Jae Kwan. AU - Park, Seong Wook. AU - Kong, Duk Hyun. AU - Lee, Cheol Whan. AU - Choi, Kee Joon. AU - Hong, Myung Ki. AU - Kim, Jae Joong. AU - Kim, You Ho. AU - Park, Seung Jung. PY - 1998/12/15. Y1 - 1998/12/15. N2 - Although coronary vasospasm can contribute to the development of unstable angina, the definite diagnostic method has not been established. The purpose of this study was to determine if ergonovine echocardiography (detection of regional wall motion abnormality during bedside ergonovine challenge) after angiographic confirmation of insignificant fixed disease would be useful and safe in detecting coronary vasospasm in patients with unstable angina. After control of chest pain with medications in patients admitted to the coronary care unit under the tentative diagnosis of unstable angina, diagnostic coronary angiography was ...
Patients with Churg-Strauss syndrome often suffer from unusual cardiac manifestations and sudden cardiac death. This differs from patients with other autoimmune disorders, who typically present with premature ischaemic heart disease. We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial infarction, complicated by bradycardic arrest. There was only minor coronary artery disease on coronary angiography. An elevated eosinophil count was noted. His medical history included allergic rhinitis with polyposis, adult-onset asthma and biopsy-proven eosinophilic oesophagitis. Review of his sinus biopsies demonstrated blood vessels with marked accumulation of eosinophils in extravascular areas. The patient, therefore, met the American College of Rheumatology criteria for Churg-Strauss syndrome. The patient was commenced on immunosuppression, with the return of the eosinophil count to within normal limits, and remains free of cardiovascular
Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in myocardial ischemia with attendant chest pain and electrocardiographic and hemodynamic changes; it is the primary pathogenetic mechanism in Prinzmetals variant angina and has been found in association with classic angina pectoris and acute myocardial infarction. Diagnosis of coronary artery spasm is firmly made only by coronary angiography. Treatment includes the use of both short- and long-acting nitrates and the slow-channel blocking agents such as verapamil, nifedipine, and perhexiline. ...
TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...
N-Aminoalkyl(perfluoroalkanoylaminophenyl)sulfonic acid amides of the formula: ##STR1## in which R.sup.1 is perfluoroalkanoylamino of 2 to 4 carbon atoms, in 3- or 4- position of the benzene ring;R.sup.2 is hydrogen or alkyl of 1 to 4 carbon atoms;R.sup.3 is hydrogen or straight or branched chain alkyl of 1 to 4 carbon atoms;R.sup.4 is straight or branched chain alkyl of 1 to 4 carbon atoms; andn is one of the integers 2, 3 or 4;or a pharmaceutically acceptable salt thereof, are Class I anti-arrhythmic agents useful in the treatment of cardiac arrhythmias and conditions characterized by coronary arteries vasospasm and myocardial ischemia.
Treatment in the emergency department should focus on frequent evaluation (e.g. every 2 hours) of the patients respiratory status with serial FVC and NIF and intubating promptly at signs of respiratory failure. Sitting the patient upright may help temporize the patients dyspnea while preparing for intubation. Even if not intubated, patients presenting with myasthenic crises will need admission to the ICU. First line therapies include IVIG and plasmapheresis, both of which take several days to reach full clinical effect by removing acetylcholine receptor antibodies from the circulation. High dose glucocorticoid therapy and other immunosuppresants such as azathioprine and cyclosporine can be initiated but are intended as long-term therapies and do not provide any benefit in the emergent setting. Anticholinesterase use, such as pyridostigmine, remains controversial because of the risk of coronary artery vasospasm (resulting in MI) and arrhythmia. A basic infectious workup, including a chest x-ray ...
Title:Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications. VOLUME: 18 ISSUE: 20. Author(s):Hong Zhou and Yong-jun Li. Affiliation:Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.. Keywords:RhoA, Rho kinase, inhibitors, diabetes, complications, GTPase, hypertension, coronary vasospasm, stroke, atherosclerosis. Abstract:The small GTPase RhoA and its downstream effector, Rho kinase (ROCK), appear to mediate numerous pathophysiological signals, including smooth muscle cell contraction, actin cytoskeleton organization, cell adhesion and motility, proliferation, differentiation and the expression of several genes. Clinical interest in the RhoA/ROCK pathway has increased, due to emerging evidence that this signaling pathway is involved in the pathogenesis of several diseases, including hypertension, coronary vasospasm, stroke, atherosclerosis, heart failure and diabetes; ROCK is considered an important future ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Chest pain following successful percutaneous coronary interventions is a common problem. Although the development of chest pain after coronary interventions may be of benign character, it is disturbing to patients, relatives and hospital staff. Such pain may be indicative of acute coronary artery closure, coronary artery spasm or myocardial infarction, but may also simply reflect local coronary artery trauma. The distinction between these causes of chest pain is crucial in selecting optimal care.Management of these patients may involve repeat coronary angiography and additional intervention. Commonly, repeat coronary angiography following percutaneous transluminal coronary angioplasty (PTCA) in patients with chest pain demonstrates widely patent lesion sites suggesting that the pain was due to coronary artery spasm, coronary arterial wall stretching or was of non-cardiac origin. ...
Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested.. Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies.. So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction. ...
The decades-long research focus on the pathophysiology of coronary artery disease (CAD) has provided insights into sex-specific factors that are uniquely important in the noninvasive diagnosis of myocardial ischemic syndromes in women. Evidence gained from the landmark WISE (Womens Ischemic Syndrome Evaluation) study (1) indicates that the full spectrum of CAD in women extends beyond atherosclerotic stenoses in the epicardial coronary arteries to include dysfunction of the coronary microvasculature and endothelium. Additional conditions contributing to the full pathophysiologic spectrum of acute and chronic ischemic heart disease (IHD) in women include coronary vasospasm and coronary artery dissection which mainly affect the epicardial coronary arteries and often develop in younger women (2). The implications of these diverse conditions are substantial. They create diagnostic challenges and limit the application of traditional testing strategies which, while adequate to detect obstructive ...
Acute myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Myocardial infarction occurs when myocardial ischemia, a diminished blood supply to the heart, exceeds a critical threshold and overwhelms myocardial cellular repair mechanisms designed to maintain normal operating function and homeostasis. Ischemia at this critical threshold level for an extended period results in irreversible myocardial cell damage or death.. Critical myocardial ischemia can occur as a result of increased myocardial metabolic demand, decreased delivery of oxygen and nutrients to the myocardium via the coronary circulation, or both. An interruption in the supply of myocardial oxygen and nutrients occurs when a thrombus is superimposed on an ulcerated or unstable atherosclerotic plaque and results in coronary occlusion.1 A high-grade (,75%) fixed coronary artery stenosis caused by atherosclerosis or a dynamic stenosis associated with coronary vasospasm can also limit the supply of ...
TY - JOUR. T1 - Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs. AU - Yamamoto, Y.. AU - Tomoike, H.. AU - Egashira, K.. AU - Nakamura, M.. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Mechanism of coronary spasm was examined regarding endothelium-related relaxation and contraction produced by smooth muscle cells of spastic vessels isolated from Gottingen miniature pigs. In these pigs, coronary artery spasm was documented angiographically in vivo three months after endothelial denudation, and spastic and control segments of the coronary artery were suspended in organ chambers at their optimal length for generating tension. Applications of KCl (118 mM), acetylcholine (10-9 to 10-4 M), and PGF(2α) (10-8 to to 3 x 10-5 M) produced similar tension, at the respective doses, in both the spastic and control coronary arteries. During increasing concentrations of histamine (10-8 to 3 x 10-4 ...
Acute coronary syndrome (ACS) refers to acute myocardial ischemia caused by atherosclerotic coronary disease, and includes ST elevation myocardial infarction (STEMI), non-ST elevation MI (NSTEMI), and unstable angina. Cocaine accounts for up to 25% of acute MIs in people ages 18 to 45 years. [9] Qureshi AI, Suri MF, Guterman LR, et al. Cocaine use and the likelihood of nonfatal myocardial infarction and stroke: data from the Third National Health and Nutrition Examination Survey. Circulation. 2001;103:502-506. http://circ.ahajournals.org/content/103/4/502 http://www.ncbi.nlm.nih.gov/pubmed/11157713?tool=bestpractice.com The lifetime risk of nonfatal MI with cocaine use is 7 times the risk in nonusers. In the hour after cocaine is used, the risk of MI is 24 times the baseline risk. It is probably due to cocaine-induced coronary vasospasm and thrombosis, in addition to a direct effect on heart rate and arterial pressure. Cocaine also has direct myocardial toxic properties. [10] Amsterdam EA, ...
Physician researchers suspect that some cases of coronary artery spasm go unrecognized and are incorrectly treated with stents. The good news - there could be a simple fix to eliminate these unnecessary stenting procedures ...
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Ulcerative colitis is a crucial well being condition involving irritation, ulceration, and bleeding of the colon. Its thought-about to be an auto-immune situation for which standard medication has no treatment. The affected particular person is given steroids and different medication to manage flare-ups and bleeding. The one remedy is to remove the affected person colon. This disease can both be minor with occasional flare-ups or debilitating and severe. The interior bleeding may cause extreme anemia. Diarrhea could cause an absence of fluids and electrolytes. The ache from intestinal spasms may very well be extreme. It might truly get to the … Read the rest ...
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Hello, Im a 23-year old female. I will start off by telling you when this started and what was happening. It was January of 2005, I had my 2nd child in December of 2004. I started having chest pain at...
The more of these symptoms you have, the more likely it is that youre having a heart attack. Chest pain or pressure is the most common symptom, but some people, especially women, may not notice it as much as other symptoms. You may not have chest pain at all but instead have shortness of breath, nausea, or a strange feeling in your chest or other areas.. ...
sharp chest pains at 20? Hello..I won`t attempt to tell you what`s actually wrong with you as I`d just be guessing..But I have had similar experiences twice in my life..The first was when I was in my late 20`s..I`d get those.... ...
A CONTRIBUTION TO THE COMPARATIVE STUDY OF THE ORIGIN OF THE SYMPATHETIC AND THE ADRENALIN-SECRETING SYSTEMS AND OF THE VASCULAR MUSCLES WHICH THEY REGULATE. ...
Prinzmetal's angina: Chest pain is caused by coronary vasospasm. More common in women younger than 50 years. Person usually ... Less than 20% of all cases of chest pain admissions are found to be due to coronary artery disease. The rate of chest pain as a ... If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack"): People usually complained of a ...
Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth ... Overall, this leads to relaxation of the smooth muscle and coronary vasodilation. The effect of nicorandil as a vasodilator is ... Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic ... In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma ...
These include: coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ...
Chutkow WA, Pu J, Wheeler MT, Wada T, Makielski JC, Burant CF, McNally EM (July 2002). "Episodic coronary artery vasospasm and ... and deletion of the kir6.2 or sur2 genes leads to coronary artery vasospasm and death. Upon further exploration of sarcKATP's ...
They can cause vasospasm including coronary vasospasm and are contraindicated in people with coronary artery disease. Magnesium ...
Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular ...
... the idea of coronary artery vasospasm is still believed to contribute to the TTS disease process. The theory of vasospasm is ... Research supports the widely-held understanding that microvascular dysfunction and coronary vasospasm caused by a rapid influx ... It has been noted that when there are vasospasms, even in multiple arteries, that they do not correlate with the areas of ... It is likely that there are multiple factors at play that could include some amount of vasospasm and failure of the ...
At higher doses, it can cause raised arterial blood pressure, vasoconstriction (including coronary vasospasm) and bradycardia ... Contraindications include: atherosclerosis, Buerger's syndrome, coronary artery disease, hepatic disease, pregnancy, pruritus, ...
In a 1995 review article, he said resulting secondary effects include arrhythmia, coronary vasospasm, myocardial infarction, ... the left main anterior coronary artery is surgically blocked and a hydraulic cuff is placed around the left circumflex coronary ...
Prinzmetal angina: also known as variant angina, referring to angina (chest pain) caused by vasospasm of the coronary arteries ...
DHE and triptans should never be taken within 24 hours of each other due to the potential for coronary artery vasospasm. DHE ...
Workup of suspected Prinzmetal Angina (coronary vasospasm). [8]. Right heart catheterization, along with pulmonary function ... Coronary catheterizationEdit. Main page: Coronary catheterization. Indications for diagnostic use of coronary catheterization ... Subsets of this technique are mainly coronary catheterization, involving the catheterization of the coronary arteries, and ... where it can be maneuvered into the coronary arteries through the coronary ostia.[5] In this position, the interventional ...
This can also occur in people with coronary vasospasm, a type of myocardial infarction involving severe constriction of the ... 2001). "Acute coronary syndromes. The diagnostic role of troponins". Thromb. Res. 103 (1): 63-69. CiteSeerX 10.1.1.500.6908. ... Zethelius B, Johnston N, Venge P (February 2006). "Troponin I as a predictor of coronary heart disease and mortality in 70-year ... October 1996). "Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes ...
In addition, beta-blockers can increase coronary vasospasm and ischemia. Opiates should be used with caution. In addition to ... These mediators can precipitate coronary artery spasm and accelerate the rupture of atheromatous plaques of the coronary ... SPECT have revealed severe myocardial ischemia while coronary angiography showed normal coronary arteries. Furthermore, with ... Acute coronary event protocol is applied and type II can be treated similarly to type I for cardiac symptom control. Glucagon ...
The role of esophagocardiac reflex in the pathogenesis of coronary vasospasm: a case report. Z Gastroenterol. 2003; 41: 455(A ...
... coronary vasospasm] without angina." Autopsy revealed localized fibrosis of the left papillary muscles, but no evidence of ... Rowe, William J. (May 1991). "A World Record Marathon Runner with Silent Ischemia without Coronary Atherosclerosis". Chest. 99 ... coronary atherosclerosis. Mah has been described as "an early leader of the modern running boom". Joe Henderson wrote an ...
... directly preventing coronary artery vasospasm). They are not used in the treatment of unstable angina . In vitro, they dilate ... Pfister M, Seiler C, Fleisch M, Göbel H, Lüscher T, Meier B (October 1998). "Nitrate induced coronary vasodilatation: ... reducing heart rate and improving coronary blood flow. In vivo, the vasodilation and hypotension trigger the baroreceptor ... the coronary and peripheral arteries and have negative inotropic and chronotropic effects - decreasing afterload, improving ...
No recent studies have been identified that show the benefit of beta blockers in reducing coronary vasospasm, or coronary ... because of the risk of coronary vasospasm.[citation needed] Though, in general, beta blockers improve mortality in patients who ... Beta blockers should not be used as a first-line treatment in the acute setting for cocaine-induced acute coronary syndrome ( ... Page RL, Utz KJ, Wolfel EE (December 2007). "Should beta-blockers be used in the treatment of cocaine-associated acute coronary ...
... severe but transient neurological symptoms thought to be caused by cerebral vasospasm, coronary disease and early-onset ... coronary disease and dementia. The skin manifestations may precede the neurologic symptoms by years. Sneddon's syndrome is a ...
The mechanism that causes such intense vasospasm, as to cause a clinically significant narrowing of the coronary arteries is so ... Heberden in that it appeared due to episodic vasospasm of coronary arteries that were typically not occluded by pathological ... eosinophilic coronary periarteritis: a very rare form of coronary artery spasm; it is due to non-allergic infiltration of ... Swarup S, Grossman SA (2018). "Coronary Artery Vasospasm". PMID 29261899. Cite journal requires ,journal= (help) Prinzmetal, ...
... reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina. They have minimal ... to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. N-type, L-type, and T-type ... This substance can pass the blood-brain barrier and is used to prevent cerebral vasospasm. Nisoldipine (Baymycard, Sular, ...
Unlike angina pectoris, commonly caused due to ischemia of the heart muscle secondary to coronary artery occlusion or vasospasm ... Like acute coronary syndrome which precedes or is a sign of a heart attack, renal angina is used as a herald sign for a kidney ... revolutionized the survival for acute coronary syndrome (ACS). Without correct context, the performance of troponin for ...
Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. Vasospasm ... Regarding coronary vasospasm, one surgical intervention, referred to as percutaneous coronary intervention or angioplasty, ... Another surgical intervention is coronary artery bypass. Coronary artery vasospasm Raynaud's phenomenon, a vasospastic disorder ... Vasospasm typically appears 4 to 10 days after subarachnoid hemorrhage. Along with physical resistance, vasospasm is a main ...
"Positron emission tomography with oxygen-15 of stunned myocardium caused by coronary artery vasospasm after recovery". British ...
... coronary vasospasm) The patient being examined or treated is usually awake during catheterization, ideally with only local ... A coronary catheterization is a minimally invasive procedure to access the coronary circulation and blood filled chambers of ... that coronary catheterization does not allow the recognition of the presence or absence of coronary atherosclerosis itself, ... Coronary artery luminal narrowing reduces the flow reserve for oxygenated blood to the heart, typically producing intermittent ...
Angina due to coronary vasospasm is also known as variant angina. Hung, Ming-Jui; Hu, Patrick; Hung, Ming-Yow (2014). "Coronary ... Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion. In ... Due to the challenge of capturing episodes of coronary vasospasm spontaneously, provocative testing to induce coronary ... When coronary vasospasm causes an artery to undergo complete occlusion, an EKG might show evidence of ST-segment elevation in ...
... reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina. They have minimal ... Nimodipine (Nimotop) This substance can pass the blood-brain barrier and is used to prevent cerebral vasospasm. ... to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. ...
... coronary vasospasm) Right heart catheterization, along with pulmonary function testing and other testing should be done to ... Coronary angiography is a diagnostic procedure that allows visualization of the coronary vessels. Fluoroscopy is used to ... A common example of cardiac catheterization is coronary catheterization that involves catheterization of the coronary arteries ... Acute coronary syndromes: ST elevation MI (STEMI), non-ST Elevation MI (NSTEMI), and unstable angina Evaluation of coronary ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ... Coronary artery bypass grafting (CABG). Medications[edit]. *Statins, which reduce cholesterol, reduce the risk of coronary ... Percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG)[10]. Medication. Aspirin, beta blockers, ... Coronary artery disease. Synonyms. Atherosclerotic heart disease,[1] atherosclerotic vascular disease,[2] coronary heart ...
Raynaud's phenomenon functional vasospasm.[clarification needed] It is distinct from neurogenic claudication, which is ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Spontaneous coronary artery dissection (SCAD). *කිරීටක ශ්‍යානිය (Coronary thrombosis). *Coronary vasospasm. *Myocardial bridge ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ... In men, coronary disease is more frequent, while in women, high systolic blood pressure and valvular heart disease are more ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ... Cardiovascular factors known to be associated with the development of AF include high blood pressure, coronary artery disease, ...
Vasospasm[edit]. See also: Subarachnoid_hemorrhage § Vasospasm. Vasospasm, referring to blood vessel constriction, can occur ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... The vasospasm is thought to be secondary to the apoptosis of inflammatory cells such as macrophages and neutrophils that become ... Rebleeding, hydrocephalus (the excessive accumulation of cerebrospinal fluid), vasospasm (spasm, or narrowing, of the blood ...
Intravascular ultrasound image of a coronary artery (left), with color-coding on the right, delineating the lumen (yellow), ... vasospasm from a subarachnoid hemorrhage (bleeding from a ruptured aneurysm), and other problems. ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
No recent studies have been identified that show the benefit of beta blockers in reducing coronary vasospasm, or coronary ... because of the risk of coronary vasospasm.[citation needed] Though, in general, beta blockers improve mortality in patients who ... Beta blockers should not be used as a first-line treatment in the acute setting for cocaine-induced acute coronary syndrome ( ... Page RL, Utz KJ, Wolfel EE (December 2007). "Should beta-blockers be used in the treatment of cocaine-associated acute coronary ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ... James, TN (Dec 1965). "Anatomy of the coronary arteries in health and disease". Circulation. 32 (6): 1029. doi:10.1161/01.cir. ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary thrombosis(英语:Coronary thrombosis). *Coronary vasospasm(英语:Coronary vasospasm) ... Coronary artery dissection(英语:Coronary artery dissection). * ... Coronary artery aneurysm(英语:Coronary artery aneurysm). * ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
CAD · Coronary thrombosis · Coronary vasospasm · Coronary artery aneurysm · Coronary artery dissection · Myocardial Bridge ... Ornish, Dean; एवं अन्य (1990). "'Can lifestyle changes reverse coronary heart disease?' The Lifestyle Heart Trial". Lancet. 336 ... Angina pectoris (Prinzmetal's angina, Stable angina) · Acute coronary (Unstable angina, Myocardial infarction / heart attack) ... Andraws R, Berger JS, Brown DL (2005). "Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ... coronary catheterization may be used to identify possibilities for revascularisation through percutaneous coronary intervention ... X-ray images are called angiograms.[44] Heart failure may be the result of coronary artery disease, and its prognosis depends ... Common causes of heart failure include coronary artery disease including a previous myocardial infarction (heart attack), high ...
They are used as tests to help diagnose emboli, stenosis, vasospasm from a subarachnoid hemorrhage (bleeding from a ruptured ... Coronary *Calcium scan. *CT angiography. *Abdominal and pelvic CT *Virtual colonoscopy. *CT angiography *Coronary CT ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Prinzmetal's angina - Chest pain is caused by coronary vasospasm. More common in women younger than 50 years. Person usually ... Acute coronary syndrome *Stable or unstable angina. *Myocardial infarction ("heart attack") - People usually complained of a ... If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Castle N (February 2003). "Effective relief of acute coronary syndrome". Emergency Nurse. 10 (9): 15-9. doi:10.7748/en2003.02. ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Angina due to coronary vasospasm is also known as variant angina. Hung, Ming-Jui; Hu, Patrick; Hung, Ming-Yow (2014). "Coronary ... Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion. In ... Due to the challenge of capturing episodes of coronary vasospasm spontaneously, provocative testing to induce coronary ... When coronary vasospasm causes an artery to undergo complete occlusion, an EKG might show evidence of ST-segment elevation in ...
... Calvin Ke,1 Amit Khosla,2 Margot K. Davis,2 Cameron Hague,3 and ... Coronary artery vasospasm (CAV) can be triggered by medication reactions. CAV occurring after multiple exposures to rituximab ... Angiogram revealed evidence of coronary vasospasm. The patient was successfully treated with amlodipine. This case underlines ...
The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies ... coronary artery vasospasm derives from a vascular smooth muscle-cell extrinsic process. To reduce this secondary vasospasm, we ... Secondary coronary artery vasospasm promotes cardiomyopathy progression Am J Pathol. 2004 Mar;164(3):1063-71. doi: 10.1016/ ... The infarct-like pattern of cardiac degeneration has led to the hypothesis that coronary artery vasospasm underlies ...
... focal coronary artery vasospasm, dynamic coronary obstruction Overview. Coronary vasospasm is a multi-factorial, transient, and ... Coronary vasospasm can be secondary to PCI. Click here for more information about PCI-induced coronary vasospasm. ... Catheter-induced coronary vasospasm is usually short-lived. Catheter-induced coronary vasospasm is most prone to occur at the ... Rotoblator cases are more prone to coronary vasospasm. The reported incidence of rotoblater cases with coronary vasospasm ...
Coronary Artery Vasospasm or Prinzmetals Angina Chest pain/discomfort caused by muscle spasm of the muscle within the walls of ... A cardiac stress test or angiogram are often required to rule out significant blockages in the coronary arteries ...
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels. ... Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels. ...
Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.. F R Laurindo, P L da Luz, L ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ...
Coronary Angiography, Coronary Artery Disease, Coronary Vasospasm, Drug-Eluting Stents, Electrocardiography, Ergonovine, Heart ... The Significance of Vasospasm in Stable Coronary Artery Disease. Aug 27, 2015 , ; Dr. Udo P. Sechtem, MD, FACC Expert Analysis ... Angiographic and clinical characteristics of patients with acetylcholine-induced coronary vasospasm on follow-up coronary ... A tendency for coronary vasospasm seems to be rather common in patients with chronic stable angina irrespective of the degree ...
... to exclude coronary vasospasm. Further study and analysis is required to investigate the association of coronary vasospasm as a ... Figure 2. Right coronary angiography. A: initial coronary angiography revealed a dominant right coronary artery (RCA) with a ... Right radial artery access coronary angiography revealed a normal left coronary system. The right coronary artery was the ... These findings suggest that coronary artery vasospasm may have contributed to the aetiology in this case of TTC. This case adds ...
We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial ... There was only minor coronary artery disease on coronary angiography. An elevated eosinophil count was noted. His medical ... Coronary artery vasospasm in a patient with Churg-Strauss syndrome. Abstract. Patients with Churg-Strauss syndrome often suffer ... We report the case of a 56-year-old man with recurrent coronary vasospasm, including an inferoposterior ST-elevation myocardial ...
Case A 20-year-old previously healthy man presents with sudden onset of substernal chest pressure after completing football practice. His chest pain is nonradiating, nonreproducible, and nonpositional. He does not have associated palpitations, dyspnea, or diaphoresis. He reports that he has not had recent upper respiratory tract infections or contact with ill people. He does not have a history of using alcohol, tobacco, or illicit drugs. He has no family history of sudden cardiac death or …. Read More ...
... of inflammatory mediators such as histamine and cytokines by mast cells and eosinophils resulting in either coronary vasospasm ... INTRODUCTION Kounis syndrome is an acute coronary syndrome occurring secondary to an anaphylactic reaction. A wide variety of ... Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome ... "Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome," The Medicine Forum: Vol. 17 , ...
Coronary microcirculation / coronary vasospasm / endothelial injury / endothelin / RhoA / ヘンドセリン / 攣縮 / アセチルコリン. ... Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel porcine model.. Research Project ... ET-1 plays a crucial role for coronary microvascular spasm and the blockade of ET-1 may be beneficial for treating coronary ... Journal Article] Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm ...
Coronary Vasospasm and Coronary Atherosclerosis Message Subject (Your Name) has forwarded a page to you from JACC: Journal of ... 1980) Some clinical considerations regarding the relation of coronary vasospasm to coronary atherosclerosis: a hypothetical ... Coronary artery spasm-related acute coronary syndrome in patients with coexisting spasm of angiographically normal coronary ... 1990) Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81:491-497. ...
Phentermine and Coronary Vasospasm-Induced Myocardial Infarction. Phentermine and Coronary Vasospasm-Induced Myocardial ... We present two cases of women presenting with chest pain found to have severe coronary vasospasm in the setting of recent ... Women presenting to the cardiac catheterization laboratory with normal coronary arteries without significant atherosclerotic ...
Coronary Artery Vasospasm. Introduction. Coronary artery vasospasm (CAVS) is a constriction of the coronary arteries that can ... Takeyoshi D,Kikuchi S,Miyake K,Tatsukawa T,Kobayashi D,Uchida D,Kitani Y,Kamiya H,Azuma N, Fatal Vasospasm of the Coronary ... However, some of these patients return to vasospasm in another location. Thus, coronary stenting with long-term medical therapy ... Close monitoring is required because recurrence of coronary vasospasm is common, which in some patients can prove fatal. (Level ...
... Przybojewski, J. Z. ... Acute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? A case report . S Afr Med J, 66(10 ... Ergometrine maleate provocation on this occasion failed to demonstrate any coronary vasospasm. Possible pathophysiological ... Cardiac catheterization a further 4 months later documented no further filling defect in the LAD branch and the coronary ...
Acute coronary vasospasm secondary to industrial nitroglycerin withdrawal : a case presentation and review. Przybojewski, J. Z. ... We postulate that this patients clinical features were a direct result of severe vasospasm affecting the left coronary artery ... also strongly suggested that withdrawal from contact with industrial NG precipitated this potentially lethal coronary vasospasm ... An ergonovine (ergometrine) maleate provocative test failed to elicit coronary artery spasm, although this was undertaken while ...
Regarding coronary vasospasm, one surgical intervention, referred to as percutaneous coronary intervention or angioplasty, ... Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. ... Like physical resistance, vasospasms can occur due to atherosclerosis. Vasospasm is the major cause of Prinzmetals angina. ... Vasospasm typically appears 4 to 10 days after subarachnoid hemorrhage. Along with physical resistance, vasospasm is a main ...
"Coronary Vasospasm" by people in this website by year, and whether "Coronary Vasospasm" was a major or minor topic of these ... "Coronary Vasospasm" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Coronary Vasospasm" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Coronary Vasospasm". ...
Table of Contents: 00:02 - Acute Coronary Syndrome: Angina 00:15 - Acute Coronary Syndromes (ACS) 00:27 - Angina Pectoris 01:49 ... Vasospasm Turns Pink women health center, women health care, women health clinic, women s health program, centers of disease ... The animation shows how plaque buildup or a coronary artery spasm can lead to a heart attack and how blocked blood flow in a ... Raynauds Phenomenon (vasospasm in extremities) http://usmlefasttrack.com/?p=1566 Raynaud, s, Phenomenon, vasospasm, in, ...
Patients with coronary artery spasm usually have morphologic changes in the artery at the site of the spasm. Thus, platelets ... Patients with coronary artery spasm usually have morphologic changes in the artery at the site of the spasm. Thus, platelets ... segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. ... segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. ...
Coronary artery vasospasm is an important cause of chest pain syndromes that can lead to myocardial infarction, ventricular ... Coronary artery vasospasm - Description, Causes and Risk Factors:. Coronary artery vasospasm, or smooth muscle constriction of ... Coronary artery vasospasm occurs most commonly in people who smoke or who have high cholesterol or high blood pressure. It may ... Coronary artery vasospasm - Symptoms:. This variant of angina occurs at rest, usually lasting for between 5 and 30 minutes. ...
Coronary Vasospasm Decreased resting coronary flow and impaired endothelial function in patients with vasospastic angina. Saito ... Pulse pressure correlates with coronary artery calcification and risk for coronary heart disease: a study of elderly ... Primary percutaneous coronary intervention in ST-elevation myocardial infarction with an ectatic infarct-related artery. ... Long-term clinical outcomes after a percutaneous coronary intervention with a drug-eluting stent in patients with unprotected ...
Coronary vasospasm complicating cannabinoid hyperemesis syndrome. In: Journal of Cardiology Cases, Vol. 15, no.4, p. 115-118 ( ... However, the patient was readmitted very soon with a ST-elevation myocardial infarction related to coronary vasospasm. While ... the possibility of some serious cardiac event should not be neglected as cannabis seems also able to trigger coronary vasospasm ... Acute coronary syndrome ; Cannabinoid hyperemesis syndrome ; Cannabis ; Vasospasm Links. :. * [Handle]. http://hdl.handle.net/ ...
... Sarfraz Ahmed Nazir, 1 ,* Sheraz ... Coronary artery vasospasm can cause a transient, abrupt, and marked decrease in the diameter of an epicardial coronary artery. ... Multivessel coronary artery vasospasm was now considered and intra-coronary nitroglycerin given. This induced relief of chest ... Multifocal Severe Coronary Artery Vasospasm Mistaken for Diffuse Atherosclerosis: A Case Report. Multifocal Severe Coronary ...
Cardiopulmonary Resuscitation , Coronary Angiography , Coronary Vasospasm , Endoscopy, Digestive System , Heart Arrest , Humans ... Coronary Angiography / Cardiopulmonary Resuscitation / Myocardial Ischemia / Coronary Vasospasm / Heart Arrest / Middle Aged ... Coronary Angiography / Cardiopulmonary Resuscitation / Myocardial Ischemia / Coronary Vasospasm / Heart Arrest / Middle Aged ... Coronary vasospasm during esophagogastroduodenoscopy / 대한내과학회지 Dae-Hyeon CHO; Jeong-Ho PARK; Jung-Hun KWON; Hyun-Seo KIM; Jae- ...
Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease Some patients with ... Eosinophilia-Associated Coronary Artery Vasospasm in Patients with AERD. Eosinophilia-Associated Coronary Artery Vasospasm in ... Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. Some patients with ... Although uncommon, patients with AERD can develop eosinophilia-associated coronary artery vasospasm, which is occasionally ...
... thus they are known to cause MI secondary to coronary vasospasm. Here we showed that transient coronary vasospasm in a new born ... Transient Coronary Vasospasm in a Newborn Due to Maternal Cannabis Use during Pregnancy ... If necessary a coronary angiography should design to evaluate coronary arteries.. Author(s): Huseyin Avni Solgun and Isa ... Cannabis use during pregnancy can induce transient coronary vasospasm and ischemia in new born. These patients should be ...
What makes you think your patient has coronary artery vasospasm? See chapter on Angina Pectoris (3606) for information related ... At a Glance Ischemia of the myocardium results when coronary blood flow is reduced by stenosis of the coronary arteries, ... At a Glance Acute coronary syndrome (ACS) is a complex group of symptoms associated with acute myocardial ischemia. Many ... abnormal constriction of the coronary microcirculation, or reduced oxygen carrying capacity of the blood. When the delivery of ...
  • A subsequent study distinguished this type of angina from classical angina pectoris further by showing normal coronary arteries on cardiac catheterization. (wikipedia.org)
  • For example, cocaine use can trigger vasospasm in coronary arteries through its actions on adrenergic receptors causing vasoconstriction. (wikipedia.org)
  • Ultimately, when large coronary arteries undergo vasospasm, this can lead to either complete or transient occlusion of blood flow within the artery. (wikipedia.org)
  • However, the vascular smooth muscle sarcoglycan complex was intact in the coronary arteries of gamma-sarcoglycan hearts with perturbation of the sarcoglycan complex only within the adjacent myocytes. (nih.gov)
  • This scenario is not infrequent as more than 50% of patients with suspected coronary artery disease are found to have unobstructed coronary arteries when coronary angiography is performed. (acc.org)
  • It is well documented that patients with chest pain and unobstructed coronary arteries have a high morbidity with more depression and anxiety, premature loss of workforce and more need for antianginal medication causing higher costs to the healthcare systems than patients with obstructive coronary artery disease. (acc.org)
  • One of the functional abnormalities causing stable angina despite unobstructed coronary arteries is coronary artery spasm which can occur at the epicardial level as well as in the coronary microcirculation. (acc.org)
  • 13 They showed that ischemia occurred earlier following ergonovine administration indicating that ergonovine-induced constriction of peripheral coronary arteries or collaterals was responsible for this observation. (acc.org)
  • 1 ) sought to determine the prevalence of coronary spasm in angina patients with angiographically normal coronary arteries. (onlinejacc.org)
  • They excluded per-protocol patients with significant coronary atherosclerosis, adhering to the dogma for searching coronary artery spasm only in patients with normal and near-normal coronary arteries. (onlinejacc.org)
  • Women presenting to the cardiac catheterization laboratory with normal coronary arteries without significant atherosclerotic disease is a common presentation. (bvsalud.org)
  • Coronary artery vasospasm (CAVS) is a constriction of the coronary arteries that can cause complete or near-complete occlusion of the vessel. (statpearls.com)
  • Cardiac catheterization 2 months later demonstrated a significant area of myocardial damage as well as a large mural thrombus, but the coronary arteries appeared normal apart from a large irregular filling defect in the proximal left anterior descending (LAD) branch, apparently due to a thrombus. (sun.ac.za)
  • Cardiac catheterization a further 4 months later documented no further filling defect in the LAD branch and the coronary arteries appeared free of disease. (sun.ac.za)
  • Cardiac catheterization revealed a normal myocardial haemodynamic system and selective coronary arteriography delineated coronary arteries free from any obstructive lesions. (sun.ac.za)
  • Spasm of the large- or medium-sized coronary arteries. (sickkids.ca)
  • L-type calcium channel blockers can induce dilation of the coronary arteries while also decreasing the heart's demand for oxygen by reducing contractility, heart rate, and wall stress. (wikipedia.org)
  • Coronary arteries contain both postjunctional alpha1- and beta1-adrenoceptors, and both are accessible to norepinephrine released from the sympathetic nerves. (hku.hk)
  • In patients with spasm of the coronary arteries, blockade of the beta1-adrenoceptors may aggravate the spasm by permitting the unopposed constrictor action of the sympathetic nerves on the alpha1-adrenoceptors on these vessels. (hku.hk)
  • Selective coronary angiography demonstrated several obstructive stenoses in the right and intermediate coronary arteries (Figures 2(a) - 2(b) ). (prinzmetal.org)
  • At this stage, the patient fortuitously revealed that she was told she had unobstructed coronary arteries at angiography the previous year. (prinzmetal.org)
  • Apparent stenoses in (a) intermediate and (b) right coronary arteries. (prinzmetal.org)
  • Subsequent attenuation of lesions in the (c) intermediate and (d) right coronary arteries following administration of intra-coronary nitrate. (prinzmetal.org)
  • If necessary a coronary angiography should design to evaluate coronary arteries . (imedpub.com)
  • At a Glance Ischemia of the myocardium results when coronary blood flow is reduced by stenosis of the coronary arteries, abnormal constriction of the coronary microcirculation, or reduced oxygen carrying capacity of the blood. (renalandurologynews.com)
  • Patients typically present with blanching of the fingers or toes in which the digits appear white, which is attributed to vasospasm of the digital arteries and resultant ischemia. (thefreedictionary.com)
  • This study was designed to test the hypothesis of a possible role of serotonin in the pathogenesis of myocardial ischemia in patients with pure vasospastic angina, since serotonin is known to cause contraction in isolated coronary arteries. (ahajournals.org)
  • Ingestion of cocaine can cause vasoconstriction of coronary arteries, thus producing chest pain similar to heart attack. (wikipedia.org)
  • Thus, the primary effect of sympathetic stimulation on the coronary arteries is the alpha-adrenergic mediated vasoconstriction. (booktopia.com.au)
  • Functionally inner- vated alpha-adrenoceptors have been documented both in large coronary con- ductance arteries and in the small resistance vessels. (booktopia.com.au)
  • 6. Regulation of large coronary arteries by beta adrenergic mechanisms in conscious dogs. (booktopia.com.au)
  • 7. The role of alpha-adrenergic activity in large and small coronary arteries in man. (booktopia.com.au)
  • 2 Further diagnostic workup using angiography may reveal coronary arteries with or without atherosclerotic narrowings. (jabfm.org)
  • Subsets of this technique are mainly coronary catheterization , involving the catheterization of the coronary arteries , and catheterization of cardiac chambers and valves of the cardiac system. (wikipedia.org)
  • Cardiac catheterization requires the use of fluoroscopy to visualize the path of the catheter as it enters the heart or as it enters the coronary arteries. (wikipedia.org)
  • The coronary arteries are known as "epicardial vessels" as they are located in the epicardium, the outermost layer of the heart. (wikipedia.org)
  • [7] At this point, a catheter is guided over the wire into the ascending aorta, where it can be maneuvered into the coronary arteries through the coronary ostia. (wikipedia.org)
  • The precipitating event is blockage in the coronary arteries or a mismatch between cardiac tissue demand and supply. (arupconsult.com)
  • Exercise should help you keep your coronary arteries clear of plaque, which can lead to them closing up. (healingwell.com)
  • Acute coronary syndrome (ACS) refers to any group of symptoms attributed to obstruction of the coronary arteries . (wikidoc.org)
  • The endothelium of coronary arteries are damaged by the risk factors resulting in endothelial dysfunction , leading to the formation of atherosclerotic plaque . (wikidoc.org)
  • 10 This anticlotting-factor deficiency predisposes to in-situ thrombosis, causing acute myocardial infarction in the presence of previously normal or minimally diseased coronary arteries. (mja.com.au)
  • The study is aimed at evaluating the real incidence of normal coronary arteries and the role of alternative substrates of myocardial ischemia in patients with acute coronary syndrome (ACS) but with no coronary artery disease (CAD) in a real world secondary care public hospital. (springer.com)
  • Myocardial infarction complicating hormone replacement therapy in a young woman with normal coronary arteries. (springer.com)
  • Multivessel vasospasm of epicardic coronary arteries as in Prinzmetal angina. (escardio.org)
  • The right and left coronary arteries most often arise independently from individual ostia in association with the right and left aortic valve cusps. (scribd.com)
  • Focal coronary spasm is limited to a localized segment of the coronary artery . (wikidoc.org)
  • Multifocal coronary spasm involves several localized segments of the same coronary artery . (wikidoc.org)
  • A subtype of epicardial coronary artery spasm is known as Prinzmetal's angina . (wikidoc.org)
  • Coronary spasm can be explained by a hyperreactivity to vasoconstrictor stimuli that results from endothelial dysfunction or primary hyperreactivity of smooth muscle cells . (wikidoc.org)
  • [6] In fact, according to a study involving 2251 patients, coronary artery spasm has been estimated to account for approximately 41% of Japanese patients with angina pectoris who underwent angiography . (wikidoc.org)
  • [7] In addition, coronary spasm in Japanese is characterized by a diffuse hyperreactivity as manifested by a segmental pattern of spasm as well as by a multivessel involvement compared to focal involvement in other populations. (wikidoc.org)
  • 9 Although epicardial coronary artery spasm is frequently associated with angina pectoris at rest, it has been also described in patients with purely exercise-related symptoms. (acc.org)
  • Histological analysis revealed that ET_A antagonist suppressed the downstream vascular remodeling induced by repeated ED. ET-1 plays a crucial role for coronary microvascular spasm and the blockade of ET-1 may be beneficial for treating coronary vasospasm. (nii.ac.jp)
  • However, the concept of coronary spasm has evolved since then. (onlinejacc.org)
  • The relevance of coronary spasm has been demonstrated in clinical scenarios other than variant angina (i.e., stable angina) ( 13,14 ), in which involvement of the coronary microcirculation has been suggested as well ( 15 ). (onlinejacc.org)
  • Moreover, it is now accepted that the degree of spasm can be affected by a number of factors, including resting vasomotor tone, segmental epicardial coronary artery hyperactivity, and organic stenosis ( 16,17 ). (onlinejacc.org)
  • The test was considered positive for spasm when either an epicardial coronary flow reduction of ≥75% at angiography or ischemic electrocardiographic changes occurred during symptom reproduction. (onlinejacc.org)
  • An ergonovine (ergometrine) maleate provocative test failed to elicit coronary artery spasm, although this was undertaken while the patient was on nitrate and calcium-blocker therapy. (sun.ac.za)
  • Vasospasm refers to a condition in which an arterial spasm leads to vasoconstriction . (wikipedia.org)
  • Patients with coronary artery spasm usually have morphologic changes in the artery at the site of the spasm. (hku.hk)
  • In this patient , we were able to demonstrate a focal spasm by coronary angiography . (bvsalud.org)
  • Coronary angiography revealed coronary artery spasm which responded to nitroglycerin. (ejcrim.com)
  • Coronary spasm as a cause of Takotsubo cardiomyopathy and intraventricular obstruction. (ejcrim.com)
  • The role of coronary spasm in underlying disease-free patients who were resuscitated from sudden cardiac arrest remained uncertain. (nih.gov)
  • Electrophysiologic abnormalities were found in 13 of the 15 patients in group I. In group II, spontaneous attack of coronary spasm occurred in four patients during the observation period, and coronary spasm was induced in three of the remaining six period of 32 +/- 23 months, whereas no patients in group II had recurrence of sudden cardiac arrest at a median follow-up of 32 months (range, 10 to 72 months). (nih.gov)
  • Coronary spasm was involved in the pathogenesis of sudden cardiac arrest in survivors without identifiable underlying heart disease. (nih.gov)
  • A neurally-mediated mechanism, activated by the mechanical effects of the transseptal puncture on the interatrial septum and leading to coronary artery spasm, may be considered as a possible explanation of this phenomenon. (biomedsearch.com)
  • 2. Relation of coronary arterial spasm to sites of organic stenosis. (booktopia.com.au)
  • The right coronary artery revealed a 70% stenosis in the proximal portion, which was believed to represent coronary spasm. (jabfm.org)
  • She was believed to have an acute coronary syndrome from coronary spasm. (jabfm.org)
  • however, when in the presence of an atherosclerotic plaque, a coronary spasm can result in a number of other complications such as rupturing of the plaque, coronary thrombosis and even myocardial infarction. (news-medical.net)
  • In patients with coronary spasm, OCT can rule out the existence of underlying coronary atherosclerotic disease not detected by coronary angiography. (revespcardiol.org)
  • Coronary artery spasm plays an important role in the pathogenesis of angina, acute myocardial infarction, arrhythmia, and sudden death [ 7 - 10 ]. (hindawi.com)
  • The precise mechanism of coronary spasm, however, is not fully understood but seems to be associated with inflammatory disease [ 11 ]. (hindawi.com)
  • However, little studies have focused on the factors that might be associated with coronary artery spasm in patients with CKD. (hindawi.com)
  • Balloon endothelial denudation (ED) was carried out in the epicardial left anterior descending coronary artery (LAD) every 2 weeks, for a total of four times, in 12 pigs. (nii.ac.jp)
  • 28. Left anterior descending coronary artery occlusion during transcatheter pulmonary valve implantation: successful rescue percutaneous revascularization. (elsevier.com)
  • Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction. (medscape.com)
  • 1 Despite signs and symptoms of myocardial ischemia convincing enough for a cardiologist to refer the patient for invasive diagnostic coronary angiography, a substantial number of these patients does not have a relevant stenosis. (acc.org)
  • When these patients had coronary angiography following intracoronary ergonovine administration constriction of collateral vessels associated with angina and ST-segment depression could be demonstrated in some patients. (acc.org)
  • Immediate coronary angiography revealed a severe mid-posterior left ventricular (PLV) branch of the right coronary artery stenosis. (bjcardio.co.uk)
  • Right coronary angiography. (bjcardio.co.uk)
  • A: initial coronary angiography revealed a dominant right coronary artery (RCA) with a severe 90% mid-posterior left ventricular (PLV) branch stenosis. (bjcardio.co.uk)
  • Right radial artery access coronary angiography revealed a normal left coronary system. (bjcardio.co.uk)
  • 20% diameter reduction) at coronary angiography. (onlinejacc.org)
  • Coronary angiography. (medigoo.com)
  • A patient with resting chest pain and ischaemic electrocardiography demonstrated severe coronary obstruction at catheter angiography. (prinzmetal.org)
  • This paper emphasises thorough history-taking and judicious use of nitrates during diagnostic coronary angiography in such patients. (prinzmetal.org)
  • Other more costly tests may include computed tomography coronary angiography, stress echocardiography, myocardial perfusion scanning and invasive angiography. (mja.com.au)
  • After control of chest pain with medications in patients admitted to the coronary care unit under the tentative diagnosis of unstable angina, diagnostic coronary angiography was performed. (elsevier.com)
  • Cardiac catheterization" is a general term for a group of procedures that are performed using this method, such as coronary angiography and left ventricle angiography. (wikipedia.org)
  • For example, coronary angiography is a diagnostic procedure that allows the interventional cardiologist to visualize the coronary vessels. (wikipedia.org)
  • A 72-year-old woman with stable angina was referred for coronary angiography. (revespcardiol.org)
  • Indeed, 33% of those with apparent cocaine-induced AMI had no coronary artery damage at angiography. (mja.com.au)
  • Absence of CAD is an uncommon finding in patients undergoing coronary artery angiography for ACS. (springer.com)
  • Considering the disconnect between the coronary and ventriculogram findings, a decision was made to delay percutaneous coronary intervention (PCI). (bjcardio.co.uk)
  • A decision was made to defer percutaneous coronary intervention (PCI) of the mid-PLV lesion, as a possible complication, such as no reflow or dissection, may lead to worsening of left ventricular function and put the patient at risk of cardiogenic shock and ventricular arrhythmias. (bjcardio.co.uk)
  • Myocardial no reflow after percutaneous coronary intervention (PCI) is associated with poor outcome. (yasni.com)
  • Mechanical Circulatory Support-Assisted Early Percutaneous Coronary Intervention in Acute Myocardial Infarction with Cardiogenic Shock: 10-Year National Temporal Trends, Predictors and Outcomes. (nih.gov)
  • Percutaneous coronary intervention, however, involves the use of mechanical stents to increase blood flow to previously blocked (or occluded) vessels. (wikipedia.org)
  • If necessary, the physician can utilize percutaneous coronary intervention techniques, including the use of a stent (either bare-metal or drug-eluting ) to open the blocked vessel and restore appropriate blood flow. (wikipedia.org)
  • When coronary vasospasm occurs, the occlusion temporarily produces ischemia. (wikipedia.org)
  • There are cases of coronary vasospasm that occur without any symptoms at all, leading to episodes of silent or asymptomatic myocardial ischemia. (wikipedia.org)
  • Coronary vasospasm is a multi-factorial, transient, and abrupt reduction of luminal diameter of an epicardial coronary artery due to inappropriate constriction of coronary smooth muscle that can generate distal ischemia . (wikidoc.org)
  • However, long-term follow-up studies suggest that patients with angina and ischemia, who do not display obstructive CAD, have increased coronary event rates and adverse quality of life as compared with those with no evidence of ischemia ( 2 ), underscoring the relevance of proper identification and treatment. (onlinejacc.org)
  • This vasospastic disease can cause acute ischemia and present anywhere along the spectrum of angina from stable angina to acute coronary syndrome. (statpearls.com)
  • Symptomatic vasospasm or delayed cerebral ischemia is a major contributor to post-operative stroke and death especially after aneurysmal subarachnoid hemorrhage. (wikipedia.org)
  • Along with physical resistance, vasospasm is a main cause of ischemia. (wikipedia.org)
  • Ischemia in the heart due to prolonged coronary vasospasm can lead to angina , myocardial infarction and even death. (wikipedia.org)
  • Other medications used to reduce the occurrence and severity of vasospasm and ultimately ischemia include L-type calcium channel blockers (notably nimodipine , as well as verapamil , diltiazem , nifedipine ) and beta-receptor antagonists (also known as beta blockers or β-blockers) such as propranolol . (wikipedia.org)
  • Cannabis use during pregnancy can induce transient coronary vasospasm and ischemia in new born. (imedpub.com)
  • At a Glance Acute coronary syndrome (ACS) is a complex group of symptoms associated with acute myocardial ischemia. (renalandurologynews.com)
  • Our data suggest that among patients with the clinical presentation of unstable angina, coronary vasospasm is the main cause of myocardial ischemia in a considerable number of patients with a normal or near-normal angiogram, and ergonovine echocardiography after confirmation of absence of significant fixed disease is useful and safe for noninvasive diagnosis of coronary vasospasm in this setting. (elsevier.com)
  • Possible myocardial ischemia and/or infarction and coronary vasospasm, even in patients without a history of CAD. (drugs.com)
  • Do not use AXERT® (almotriptan malate) in patients with ischemic heart disease ( angina pectoris , history of myocardial infarction , or documented silent ischemia), or in patients who have symptoms or findings consistent with ischemic heart disease , coronary artery vasospasm , including Prinzmetal's variant angina, or other significant underlying cardiovascular disease. (wikidoc.org)
  • described a type of chest pain resulting from coronary vasospasm, referring to it as a variant form of classical angina pectoris. (wikipedia.org)
  • Unlike classical angina pectoris, traditional cardiovascular risk factors are not thought to be significantly associated with coronary vasospasm. (wikipedia.org)
  • The clinical hallmark of stable coronary artery disease is angina pectoris caused by physical or emotional stress that is relieved by rest or nitroglycerine intake. (acc.org)
  • In addition, many patients with suspected coronary artery disease report angina pectoris at rest and the Canadian Cardiovascular Society Classification for stable angina states that resting angina may occur at every class together with angina on exertion. (acc.org)
  • It is an important cause of morbidity, both in patients with proven coronary artery disease and in those with "a variant form of angina pectoris" as originally described by Prinzmetal et al. (prinzmetal.org)
  • See chapter on Angina Pectoris (3606) for information related to biochemical testing associated with coronary artery vasospasm. (renalandurologynews.com)
  • 1 The most common serious underlying causes for this symptom are acute coronary syndromes (ACS), incorporating acute myocardial infarction and unstable angina pectoris. (mja.com.au)
  • In very rare cases, as with other 5HT 1B/1D agonists, coronary vasospasm, angina pectoris and myocardial infarction have been reported. (medicines.org.uk)
  • W. KUPPER Coronary artery vasoconstriction is not only the mechanism responsible for Prinzmetal's variant angina, but may also be involved in stable angina pectoris and myocardial infarction. (booktopia.com.au)
  • In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. (hindawi.com)
  • This study assessed the role of the superoxide anion, the hydroxyl radical, and hydrogen peroxide in vasoconstriction and mural thrombosis after coronary artery angioplasty in intact dogs. (ahajournals.org)
  • The pathophysiology of Kounis syndrome is thought to be due to the release of inflammatory mediators such as histamine and cytokines by mast cells and eosinophils resulting in either coronary vasospasm, myocardial infarction or stent thrombosis. (jefferson.edu)
  • coronary vasospasm, thrombosis or coronary embolus? (sun.ac.za)
  • Acute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? (sun.ac.za)
  • 18. Recurrent myocardial infarctions due to thrombosis of a coronary aneurysm in neurofibromatosis type: is antiplatelet treatment enough? (elsevier.com)
  • New onset angina however should be considered as a part of acute coronary syndrome, since it suggests a new problem in a coronary artery .Though ACS is usually associated with coronary thrombosis , it can also be associated with cocaine use. (wikidoc.org)
  • A significant group of patients with variant angina have underlying obstructive coronary artery disease. (wikidoc.org)
  • Of the 376 European patients with stable angina and suspected coronary artery disease 47% had no epicardial stenosis (≤20% narrowings). (acc.org)
  • Indeed, in the absence of obstructive coronary artery disease (CAD), management of patients with angina represents an unsolved challenge. (onlinejacc.org)
  • CAVS appears to be a heterogeneous disease but does not follow the traditional risk factors in the development of coronary artery disease. (statpearls.com)
  • A German study found that every fourth patient with suspected obstructive coronary artery disease (CAD) had no culprit lesion, of these tested with acetylcholine, 50% were confirmed to be due to CAVS. (statpearls.com)
  • Myocardial perfusion imaging may be helpful in ruling out obstructive atherosclerotic disease between episodes of coronary artery vasospasm. (medigoo.com)
  • Thought you might appreciate this item(s) I saw at Coronary Artery Disease. (lww.com)
  • At a Glance Biochemical markers of lipid status and/or inflammation can provide data useful in assessing the risk of cardiovascular disease in patients who may have conventional markers of increased cardiovascular risk, such as cigarette smoking, elevated blood pressure, and diabetes mellitus, but are currently asymptomatic and have no history of coronary heart disease. (renalandurologynews.com)
  • Type I describes allergen-induced coronary vasospasm in the absence of preexisting disease. (thefreedictionary.com)
  • The purpose of this study was to determine if ergonovine echocardiography (detection of regional wall motion abnormality during bedside ergonovine challenge) after angiographic confirmation of insignificant fixed disease would be useful and safe in detecting coronary vasospasm in patients with unstable angina. (elsevier.com)
  • Ergonovine echocardiography was performed in 52 patients with insignificant disease, and coronary vasospasm was documented in 33 (63%, 33 of 52). (elsevier.com)
  • Vascular reactivity to mental stress is associated with poor cardiovascular disease outcomes in females following acute coronary syndrome. (nih.gov)
  • Sex-Specific Differences in Coronary Blood Flow and Flow Velocity Reserve in Symptomatic Patients with Non-obstructive Disease. (nih.gov)
  • The exact cause of her ongoing unstable angina was uncertain but may have reflected either vasospasm superimposed upon an area of atherosclerotic coronary disease, or vasospasm induced plaque rupture. (biomedsearch.com)
  • Panidis IP, Ren JF, Kotler MN, Mintz G, Iskandrian A, Ross J, Kane S (1983) Two-dimensional echocardiographic estimation of right ventricular ejection fraction in patients with coronary artery disease. (springer.com)
  • Recognition of this ECG abnormality is of paramount importance because this syndrome represents a preinfarction stage of coronary artery disease (CAD) that often progresses to a devastating anterior wall MI. (medscape.com)
  • Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement: Implications for Clinical Indices of Coronary Stenosis Severity. (edu.au)
  • 11. Enhanced transcardiac 1-norepinephrine response during cold pressor test in obstructive coronary artery disease. (booktopia.com.au)
  • [4] These comorbidity conditions include, aortic aneurysm , aortic stenosis , diabetes , obesity , renal insufficiency, unstable angina , uncontrolled hypertension , and extensive three-vessel coronary artery disease . (wikipedia.org)
  • Acute Coronary Syndrome - Ischemic Heart Disease. (arupconsult.com)
  • Acute coronary syndrome (ACS), formerly referred to as ischemic heart disease, refers to a large spectrum of clinical conditions, including unstable angina and myocardial infarction (MI). (arupconsult.com)
  • If patient has risk factors for coronary artery disease, know that first dose should be given in medical setting with emergency equipment at hand. (thefreedictionary.com)
  • Of those who present with sudden cardiac death, between 80-90% have 'significant' coronary artery disease (Zipes and Wellens 1998). (forensicmed.co.uk)
  • This broad range reflects different inclusion criteria for published studies, but Farb et al (1996) found acute thrombi in 54% of men with coronary disease who died suddenly - a figure suggested by other experts as being a 'reasonable' estimate (Gallagher 2002 and personal communication 2005). (forensicmed.co.uk)
  • The majority of sudden cardiac deaths occur on a background of coronary artery disease, manifested by luminal stenosis. (forensicmed.co.uk)
  • Ischemic heart disease, coronary artery vasospasm, uncontrolled hypertension. (mayo.edu)
  • 2 , 5 Cocaine appears to cause acute myocardial ischaemia or infarction in patients with and without pre-existing coronary artery disease. (mja.com.au)
  • Coronary artery disease with aborted myocardial infarction for spontaneous thrombus lysis: transient coronary occlusion by a fast-dissolving clot and spontaneous reperfusion. (escardio.org)
  • Spontaneous coronary artery vasospasm is defined as a transient total or near-total occlusion of a vessel, occurring in either a normal or diseased arterial segment, which is reversible with isosorbide dinitrate [ 1 ]. (prinzmetal.org)
  • Coronary vasospasm is a transient abnormal contraction of an epicardial coronary artery which can instigate myocardial ischaemia [ 3 ]. (prinzmetal.org)
  • Here we showed that transient coronary vasospasm in a new born due to maternal cannabis use during pregnancy. (imedpub.com)
  • Prinzmetal variant angina is characterized by angina secondary to coronary artery vasospasm, 1 typically at rest, associated with transient ST-segment deviations. (jabfm.org)
  • However, in the presence of endothelial dysfunction, an early marker of coronary atherosclerosis ( 4-6 ), ACH induces coronary vasoconstriction via receptors localized into the smooth muscle cells ( 7,8 ). (onlinejacc.org)
  • Like physical resistance, vasospasms can occur due to atherosclerosis . (wikipedia.org)
  • The occurrence of vasospasm can be reduced by preventing the occurrence of atherosclerosis . (wikipedia.org)
  • Although two-thirds of patients have concurrent atherosclerosis of a major coronary artery, this is often mild or out of proportion to the degree of symptoms. (prinzmetal.org)
  • We report a case where multifocal coronary artery vasospasm was mistaken for obstructive diffuse atherosclerosis and almost resulted in unnecessary bypass grafting. (prinzmetal.org)
  • Coronary vasospasm is commonly a result of atherosclerosis. (vidanthealth.com)
  • A Possible Relationship Among Coronary Vasospasm, Atherosclerosis and Myocardial Bridge. (nii.ac.jp)
  • Vasodilatory agents with mechanisms dependent on a functional endothelial nitric oxide synthase can cause vasoconstriction instead in the setting of endothelial dysfunction, leading to coronary vasospasm. (wikipedia.org)
  • CONCLUSIONS These data provide evidence implicating the superoxide radical in the genesis of vasoconstriction after coronary angioplasty in vivo. (ahajournals.org)
  • This suggests that vasoconstriction of small coronary vessels modulates the angina threshold and may be solely responsible for the occurrence of anginal symptoms during exercise. (acc.org)
  • Believe that atherosclerotic plaque and coronary artery rupture's, resulting in platelet aggregation, thrombus formation or vasoconstriction (Fig. 38-1, pg. (brainscape.com)
  • However, the underlying patho-physiological mecha- nisms and the importance of coronary vasoconstriction in these syndromes is still largely unknown. (booktopia.com.au)
  • Therefore, alpha-adrenoceptor mediated coronary constriction is an at- tractive hypothesis as a possible pathophysiological mechanism of inappropriate coronary vasoconstriction and cororiary vasospasm. (booktopia.com.au)
  • [3] [4] Dysfunction of the autonomic nervous system and endothelial dysfunction can lead to chronic intermittent vasospasm, which usually occurs where a fixed, non-calcified stenosis is located. (wikidoc.org)
  • The right coronary artery was the dominant artery with a severe type A lesion mid-posterior left ventricular (PLV) branch stenosis ( figure 2 ). (bjcardio.co.uk)
  • Case presentation We describe the case of a 46-year-old male with the rare coincidental finding of supravalvular aortic stenosis and coronary vasospasm leading to recurrent pulseless electrical activity cardiac arrest. (elsevierpure.com)
  • Conclusions Coronary vasospasm and supravalvular aortic stenosis are rare but potentially reversible causes of pulseless electrical activity cardiac arrest. (elsevierpure.com)
  • [ 1 ] Wellens syndrome refers to these specific electrocardiographic (ECG) abnormalities in the precordial T-wave segment, which are associated with critical stenosis of the proximal left anterior descending (LAD) coronary artery. (medscape.com)
  • taurine potentiates caffeine and may cause coronary vasospasm. (medpagetoday.com)
  • Does midodrine cause coronary vasospasm like dihydroergotamine? (healthtap.com)
  • Midodrine doesn't cause coronary vasospasm. (healthtap.com)
  • The exact pathophysiology behind coronary vasospasm has not been elucidated. (wikipedia.org)
  • Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel porcine model. (nii.ac.jp)
  • Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion. (wikipedia.org)
  • who described findings from ambulatory ECG recordings and exercise testing following intravenous ergonovine application in patients with a chronic total occlusion who had no other coronary lesions. (acc.org)
  • Left heart catheterization allows for direct intervention in cases of coronary artery occlusion. (wikipedia.org)
  • This technique is also used to assess the amount of occlusion (or blockage) in a coronary artery, often described as a percentage of occlusion. (wikipedia.org)
  • Right coronary artery is a large-caliber codominant vessel with 100% proximal occlusion. (aapc.com)
  • Arteritis, vasospasms, tachycardia, hypertension and arrhythmias are all significant adverse CV symptoms associated with chronic cannabis use that may ultimately lead to a greater risk of MIs. (news-medical.net)
  • 10 This is supported by the postmortem findings of acute platelet-rich thrombi in fatal cocaine-related infarcts in both normal and atherosclerotic coronary vessels. (mja.com.au)
  • Vasospasm is the major cause of Prinzmetal's angina . (wikipedia.org)
  • Prinzmetal's angina: Chest pain is caused by coronary vasospasm. (wikipedia.org)
  • Young patients with fewer cardiovascular risk factors (with the exception of smoking ) are at a higher risk for coronary vasospasm, as are noncalcified lesions and eccentric plaques . (wikidoc.org)
  • Some of the factors that have been proposed to contribute to coronary vasospasm include the following: Endothelial dysfunction Certain vasodilatory agents exert their effects by working via the endothelium, the cells that make up the lining of blood vessels. (wikipedia.org)
  • Endothelial dysfunction wherein there is a deficiency in the production of nitric oxide has been found to be associated with coronary vasospasm in some but not all cases. (wikipedia.org)
  • Occasionally, coronary vasospasm can be induced by angioplasty (PCI-induced), which occurs secondary to endothelial denudation and nitric oxide loss. (wikidoc.org)
  • It remains to elucidate whether this rapid RhoA activation associates with endothelial dysfunction of coronary vasospasm. (nii.ac.jp)
  • Acetylcholine, an endogenous neurotransmitter, is adopted to invasively assess the coronary endothelial function. (onlinejacc.org)
  • Coronary vasospasm is also associated with symptoms of fatigue and tiredness, dyspnea, and palpitations. (wikipedia.org)
  • We sought to characterise the demographics, length of admission, final diagnoses, long-term outcome and costs associated with the population who presented to an Australian emergency department (ED) with symptoms of possible acute coronary syndrome (ACS). (mja.com.au)
  • When symptoms do occur, they include lack of blood flow to the affected organ or, in coronary vasospasm, tightness and pain in the chest. (vidanthealth.com)
  • Also, patients with features and symptoms suggestive of the acute coronary syndrome were excluded. (scirp.org)
  • The same mediators released during acute allergic reactions are increased in blood or urine of patients suffering from acute coronary syndromes of non allergic etiology. (hospitalchronicles.gr)
  • Coronary vasospasm classically produces chest pain at rest, also known as vasospastic angina. (wikipedia.org)
  • We present two cases of women presenting with chest pain found to have severe coronary vasospasm in the setting of recent initiation of phentermine . (bvsalud.org)
  • Coronary artery vasospasm, or smooth muscle constriction of the coronary artery, is an important cause of chest pain syndromes that can lead to myocardial infarction (MI), ventricular arrhythmias, and sudden death. (medigoo.com)
  • This induced relief of chest pain marked attenuation of all visible coronary stenoses (Figures 2(c) - 2(d) ) and resolution of ST segment elevation. (prinzmetal.org)
  • Some patients with AERD and increased eosinophil cells in their blood have reported angina-like chest pain that occurs at rest, responds to systemic corticosteroid/prednisone therapy, and is presumed to be eosinophilia-associated coronary artery vasospasm. (partners.org)
  • Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack"): People usually complained of a pressure or squeezing sensation over the chest. (wikipedia.org)
  • There are several risk factors that are thought to precipitate, or trigger, episodes of coronary vasospasm. (wikipedia.org)
  • thus they are known to cause MI secondary to coronary vasospasm. (imedpub.com)
  • Serious and relatively common causes include acute coronary syndrome such as a heart attack (31%), pulmonary embolism (2%), pneumothorax, pericarditis (4%), aortic dissection (1%) and esophageal rupture. (wikipedia.org)
  • Spontaneous Coronary Artery Dissection and. (revespcardiol.org)
  • Acute myocardial infarction due to vasospasm induced by prostaglandin. (ejcrim.com)
  • Although coronary vasospasm can contribute to the development of unstable angina, the definite diagnostic method has not been established. (elsevier.com)
  • Angiographic and clinical characteristics of patients with unstable angina showing an ECG pattern indicating critical narrowing of the proximal LAD coronary artery. (medscape.com)
  • Overall two-thirds of patients undergoing the ACH test presented with abnormal coronary artery vasomotion, a finding that also confirmed the presence of the ischemic syndrome. (onlinejacc.org)
  • Between 15-75% have an acute coronary thrombus . (forensicmed.co.uk)
  • Possible explanation for the above findings could be coronary vasospasm versus thrombus. (aapc.com)
  • This usually results from an imbalance in oxygen supply and demand, which is most often caused by plaque rupture with thrombus formation in a coronary vessel, resulting in an acute reduction of blood supply to a portion of the myocardium. (scribd.com)
  • They postulated this as the course of a vasospastic epicardial coronary artery. (statpearls.com)
  • Coronary vasospastic angina (VSA) in general population is characterized by the presence of elevated levels of C-reactive protein [ 12 , 13 ] and also peripheral monocyte counts [ 14 ]. (hindawi.com)
  • Vasospasm is a sudden narrowing of an artery. (vidanthealth.com)
  • Sudden coronary death in middle age and characteristics of its victims in finland. (biomedsearch.com)
  • Studies implicate plaque erosion in 44% of sudden deaths, and ruptures as being responsible for 60 - 75% of acute coronary syndrome. (forensicmed.co.uk)
  • Coronary artery vasospasm can be classified into either spontaneous or iatrogenic. (wikidoc.org)
  • Spontaneous severe multivessel coronary artery vasospasm is a rare but important cause of morbidity. (prinzmetal.org)
  • The degree of coronary constriction in response to ACH administration can vary considerably, ranging from mild to complete or near-complete coronary flow obstruction, as typically observed in patients with variant angina ( 9 ) who present with localized hyper-responsiveness ( 10 ). (onlinejacc.org)
  • Once the catheter is in place, it can be used to perform a number of procedures including, coronary angioplasty , balloon septostomy , electrophysiology study or catheter ablation . (wikipedia.org)
  • In the absence of injury, SOD alone induced no change in coronary diameter, coronary blood flow, or platelet aggregation. (ahajournals.org)
  • In addition, chronic use of marijuana can lead to a number of other adverse CV events, including cannabis arteritis, vasospasms and platelet aggregation. (news-medical.net)
  • The exact pathogenesis of coronary vasospasm is not well understood, but some causes and contributing factors are known. (wikidoc.org)
  • Preliminary data suggest a potential role for hyperventilation and cold-pressor stress echocardiography as a noninvasive means for detecting coronary artery vasospasm, though this method may not be as sensitive as using intracoronary acetylcholine as the provocative agent. (medigoo.com)
  • Brennan A, Adams H, Galligan J, Whitbourn R. Coronary vasospasm and concurrent Takotsubo cardiomyopathy. (ejcrim.com)
  • Kounis syndrome (KS) is defined as concurrent acute coronary syndrome and allergic or hypersensitivity reactions. (archivestsc.com)
  • In addition to this, one of the risk factors for coronary vasospasm is smoking. (wikipedia.org)
  • Catheter-induced coronary vasospasm is most prone to occur at the ostium of the right coronary artery (RCA). (wikidoc.org)
  • In many cases, coronary artery vasospasm can occur spontaneously without an identifiable cause. (medigoo.com)
  • Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. (ahajournals.org)
  • We evaluated the coronary vasculature of gamma-sarcoglycan mutant mice and found microvascular filling defects consistent with arterial vasospasm. (nih.gov)
  • One-third of patients have normal coronary vasculature, and these pose a significant therapeutic dilemma as lack of clinical suspicion might potentially lead to unnecessary revascularization therapies. (prinzmetal.org)
  • Study done by Oliver M observed that changes that can be observed in the retinal vasculature like vasospasm may indirectly indicate the level of placental vascular status and hence placental insufficiency and fetal birth weight. (thefreedictionary.com)
  • Vasospasm affecting coronary, gastrointestinal, genitourinary, and placental vasculature has been described in patients with Raynaud's phenomenon. (bmj.com)
  • Multivessel coronary artery vasospasm was now considered and intra-coronary nitroglycerin given. (prinzmetal.org)
  • 2000 Fatal left main coronary artery embolism from aortic valve endocarditis following cardiac catheterization Catheter Cardiovasc Interv. (springer.com)
  • Intra-arterial nitroglycerin for intra-operative arterial vasospasm during pediatric renal transplantation. (sickkids.ca)
  • Owusu KA, Brennan J, Perelman A, Meoli E, Altshuler J. Nitroglycerin administration during cardiac arrest by coronary vasospasm secondary to misoprostol. (ejcrim.com)