Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).Angina Pectoris, Variant: A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.Ergonovine: An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.Coronary Vessels: The veins and arteries of the HEART.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Diltiazem: A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Coronary Stenosis: Narrowing or constriction of a coronary artery.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.rho-Associated Kinases: A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Coronary Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.Superoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Chest Pain: Pressure, burning, or numbness in the chest.Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.Medicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Qi: The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.MalatesSerotonin Receptor Agonists: Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Malate Dehydrogenase: An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Passive Cutaneous Anaphylaxis: An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. (1/422)

In the present study we used a bioassay to study the effects of peroxynitrite (ONOO-) on angiotensin II (A-II)-triggered tension in isolated bovine coronary arteries in order to show the consequences of the previously reported PGI2-synthase inhibition by ONOO- in this model. The following results were obtained: 1. 1 micromol L(-1) ONOO- impaired A-II-induced vasorelaxation and caused a second long lasting constriction phase. Indomethacin (10(-5)M) prevented both effects. U51605, a dual blocker of PGI2-synthase and thromboxane (TX)A2-synthase mimicked the effects of ONOO-. 2. The selective TXA2/prostaglandin endoperoxide (PGH2) receptor antagonist SQ29548 antagonized the second vasoconstriction phase after ONOO- -treatment. Since a generation of TXA2 and 8-iso-prostaglandin F2alpha could be excluded a direct action of unmetabolized PGH2 on the TXA2/PGH2 receptor was postulated. 3. ONOO- dose-dependently inhibited the conversion of 14C-PGH2 into 6-keto-PGF1alpha in isolated bovine coronary arteries with an IC50-value of 100 nM. 4. Immunoprecipitation of 3-nitrotyrosine-containing proteins with a monoclonal antibody revealed PGI2-synthase as the only nitrated protein in bovine coronary arteries treated with 1 micromol 1(-1) ONOO-. 5. Using immunohistochemistry a co-localization of PGI2-synthase and nitrotyrosine-containing proteins was clearly visible in both endothelial and vascular smooth muscle cells. We concluded that ONOO- not only eliminated the vasodilatory, growth-inhibiting, antithrombotic and antiadhesive effects of PGI2 but also allowed and promoted an action of the potent vasoconstrictor, prothrombotic agent, growth promoter, and leukocyte adherer, PGH2.  (+info)

Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. (2/422)

Japanese investigators have provided a substantial contribution in the understanding of coronary vasomotor reactivity. On occasions, their findings have been at variance with those undertaken on caucasian patients, raising speculation that vasomotor differences between races may exist. In a comparative review of the published literature, we evaluated the vasoreactive differences among Japanese and caucasian patients with variant angina or myocardial infarction. In variant angina, Japanese patients appear to have diffusely hyperreactive coronary arteries compared with caucasian people, manifested by their segmental rather than focal spasm, hyperreactive nonspastic vessels and multivessel spasm. These differences may reflect the increased basal tone among Japanese variant angina patients and may relate to controversial differences in endothelial nitric oxide production or autonomic nervous system activity. Provocative vasomotor studies of Japanese patients with a recent myocardial infarction report a higher incidence of inducible spasm than caucasian studies, an observation recently supported by a controlled study. Furthermore, the hyperreactivity was diffuse, occurring in both non-infarct- and infarct-related vessels. These observations support the existence of racial coronary vasomotor reactivity differences but require confirmation in further prospectively conducted studies.  (+info)

Intraoperative spasm of coronary and peripheral artery--a case occurring after tourniquet deflation during sevoflurane anesthesia. (3/422)

A 68-yr-old man with a 9-yr history of hypertension presented for hemiglossectomy, segmental resection of the mandible, and the radial forearm free flap grafting. Intraoperatively, facial artery spasm was observed during microvascular suturing of the radial artery to the facial artery. Simultaneously, systolic blood pressure decreased from 100 to 80 torr and the ST segment elevated to 15 mm from the base line. The possible mechanisms responsible for vasospasm in coronary as well as in peripheral arteries under sevoflurane anesthesia are discussed.  (+info)

T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. (4/422)

BACKGROUND: Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases in general. However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm. METHODS AND RESULTS: We searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm. In this study, we demonstrate the existence of 3 linked mutations in the 5'-flanking region of the eNOS gene (T-786-->C, A-922-->G, and T-1468-->A). The incidence of the mutations was significantly greater in patients with coronary spasm than in the control group (P<0.0001). Multiple logistic regression analysis with forward stepwise selection using the environmental risk factors and the eNOS gene variant revealed that the most predictive independent risk factor for coronary spasm was the mutant allele (P<0.0001). As assessed by luciferase reporter gene assays, the T-786-->C mutation resulted in a significant reduction in eNOS gene promoter activity (P<0.05), whereas neither the A-922-->G nor the T-1468-->A mutation had any affect. CONCLUSIONS: Taken together, these findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.  (+info)

A case of vasospastic angina presenting Brugada-type ECG abnormalities. (5/422)

An electrophysiological study and a provocative test of coronary artery spasm was attempted in a 68-year-old man who was having syncopal attacks and chest pain. His electrocardiogram had the characteristics of Brugada syndrome and ventricular fibrillation (VF) was induced by programmed electrical stimulation. ST-segment elevation became exaggerated by procainamide, which could not prevent the induction of VF. Coronary angiography revealed no stenotic lesions, and spasm in the left coronary artery was induced by intracoronary administration of acetylcholine with similar chest pain to that experienced before. Under treatment with diltiazem and flecainide, which suppressed the induction of VF, the patient experienced no recurrence of symptoms despite persistent ST-segment elevation. No previous reports have described coronary spasm associated with Brugada-type ECG abnormalities, and patients with syncope should be evaluated carefully.  (+info)

Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. (6/422)

The role of peroxynitrite in hypoxia-reoxygenation-induced coronary vasospasm was investigated in isolated bovine coronary arteries. Hypoxia-reoxygenation selectively blunted prostacyclin (PGI2)-dependent vasorelaxation and elicited a sustained vasoconstriction that was blocked by a cyclooxygenase inhibitor, indomethacin, and SQ29548, a thromboxane (Tx)A2/prostaglandin H2 receptor antagonist, but not by CGS13080, a TxA2 synthase blocker. The inactivation of PGI2 synthase, as evidenced by suppressed 6-keto-PGF1 alpha release and a decreased conversion of 14C-prostaglandin H2 into 6-keto-PGF1 alpha, was paralleled by an increased nitration in both vascular endothelium and smooth muscle of hypoxia-reoxygenation-exposed vessels. The administration of the nitric oxide (NO) synthase inhibitors as well as polyethylene-glycolated superoxide dismutase abolished the vasospasm by preventing the inactivation and nitration of PGI2 synthase, suggesting that peroxynitrite was implicated. Moreover, concomitant administration to the organ baths of the two precursors of peroxynitrite, superoxide, and NO mimicked the effects of hypoxia-reoxygenation, although none of them were effective when given separately. We conclude that hypoxia-reoxygenation elicits the formation of superoxide, which causes loss of the vasodilatory action of NO and at the same time yields peroxynitrite. Subsequently, peroxynitrite nitrates and inactivates PGI2 synthase, leaving unmetabolized prostaglandin H2, which causes vasospasm, platelet aggregation, and thrombus formation via the TxA2/prostaglandin H2 receptor.  (+info)

Transient severe mitral regurgitation complicating myocardial stunning due to coronary vasospasm. (7/422)

As in papillary muscle dysfunction complicating mitral prolapse, dyskinesis of the left ventricular wall underlying the papillary muscles has been shown to cause mitral regurgitation following myocardial infarction. Myocardial stunning has been experimentally evidenced to cause mitral regurgitation due to a wall motion abnormality, but it has not yet been clinically defined. We report a clinical case of transient severe mitral regurgitation complicating myocardial stunning caused by coronary vasospasm. Transient wall motion abnormality beneath the anterolateral papillary muscle was considered to be responsible for the mitral regurgitation.  (+info)

Prognostic significance of the pattern of multivessel spasm in patients with variant angina. (8/422)

Multivessel spasm in variant angina is believed to be a major prognostic factor. Three patterns of multivessel spasm have been detected: (1) spasm at different sites on different occasions (migratory spasm); (2) spasm sequentially affecting 2 different sites (sequential spasm); and (3) simultaneous spasm at more than 1 site (simultaneous spasm). The present study investigated the prognosis based on this factor for variant angina without fixed coronary stenosis and examined the influence of multivessel spasm on cardiac events. Twenty-six patients were diagnosed as having variant angina without fixed coronary stenosis using 12-lead 24-h ECG recording system and coronary cineangiography. These patients were followed up prospectively for 57.1+/-7.6 months. Of the 26 patients 13 had single-vessel spasm, 6 had migratory multivessel spasm angina, and 7 showed sequential and/or simultaneous multivessel spasm angina. The survival free of serious cardiac events and of all cardiac events was significantly lower for patients with sequential and/or simultaneous multivessel spasm than for those with migratory multivessel spasm (p<0.05, p<0.05), whereas for patients with migratory multivessel spasm the difference comparison with single-vessel spasm did not attain statistical significance (p = ns, p = ns). The results of this study suggest that there seems to be a high-risk subgroup (i.e., sequential and/or simultaneous multivessel spasm) among patients with variant angina.  (+info)

*Coronary vasospasm

... is a sudden, intense vasoconstriction of an epicardial coronary artery that causes occlusion (stoppage) or ... "Multivessel coronary vasospasm mimicking triple-vessel obstructive coronary artery disease". J Invasive Cardiol. 19 (7): E178- ... Hibino H, Kurachi Y (March 2006). "A new insight into the pathogenesis of coronary vasospasm". Circ. Res. 98 (5): 579-81. doi: ... Miwa K, Ishii K, Makita T, Okuda N (May 2004). "Diagnosis of multivessel coronary vasospasm by detecting postischemic regional ...

*Chest pain

Prinzmetal's angina - Chest pain is caused by coronary vasospasm. More common in women younger than 50 years. Patient usually ... If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack") - People usually complained of a ... However, both atypical and typical symptoms of acute coronary syndrome can occur, and in general a history cannot be enough to ...

*Migraine

They can cause vasospasm including coronary vasospasm and are contraindicated in people with coronary artery disease. ...

*Vasospasm

Regarding coronary vasospasm, one surgical intervention, referred to as percutaneous coronary intervention or angioplasty, ... Another surgical intervention is coronary artery bypass. Health portal Coronary artery vasospasm Raynaud's phenomenon, a ... Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. The ... Vasospasm typically appears 4 to 10 days after subarachnoid hemorrhage. Along with physical resistance, vasospasm is a main ...

*Ergotamine

At higher doses, it can cause raised arterial blood pressure, vasoconstriction (including coronary vasospasm) and bradycardia ... Contraindications include: atherosclerosis, Buerger's syndrome, coronary artery disease, hepatic disease, pregnancy, pruritus, ...

*George Billman

In a 1995 review article, he said resulting secondary effects include arrhythmia, coronary vasospasm, myocardial infarction, ... the left main anterior coronary artery is surgically blocked and a hydraulic cuff is placed around the left circumflex coronary ...

*Nicorandil

Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth ... Overall, this leads to relaxation of the smooth muscle and coronary vasodilation. The effect of nicorandil as a vasodilator is ... Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic ... In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma ...

*Troponin

This can also occur in people with coronary vasospasm, a type of myocardial infarction involving severe constriction of the ... 2001). "Acute coronary syndromes. The diagnostic role of troponins". Thromb Res. 103 (1): 63-69. doi:10.1016/S0049-3848(01) ... Zethelius B, Johnston N, Venge P (February 2006). "Troponin I as a predictor of coronary heart disease and mortality in 70-year ... October 1996). "Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes ...

*András Rosztóczy

The role of esophagocardiac reflex in the pathogenesis of coronary vasospasm: a case report. Z Gastroenterol. 2003; 41: 455(A ...

*Beta blocker

No recent studies have been identified that show the benefit of beta blockers in reducing coronary vasospasm, or coronary ... because of the risk of coronary vasospasm.[citation needed] Though, in general, beta blockers improve mortality in patients who ... The blockade of only beta receptors increases blood pressure, reduces coronary blood flow, left ventricular function, and ... Beta blockers should not be used as a first-line treatment in the acute setting for cocaine-induced acute coronary syndrome ( ...

*Sy Mah

... coronary vasospasm] without angina." Autopsy revealed localized fibrosis of the left papillary muscles, but no evidence of ... Rowe, William J. (May 1991). "A World Record Marathon Runner with Silent Ischemia without Coronary Atherosclerosis" (pdf). ... coronary atherosclerosis. Mah has been described as "an early leader of the modern running boom". Joe Henderson wrote an ...

*Calcium channel blocker

... reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina. They have minimal ... Calcium channel blockers are also frequently used to alter heart rate, to prevent cerebral vasospasm, and to reduce chest pain ... This substance can pass the blood-brain barrier and is used to prevent cerebral vasospasm. Nisoldipine (Baymycard, Sular, ...

*Frovatriptan

These include: coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ...

*ATP-sensitive potassium channel

Chutkow WA, Pu J, Wheeler MT, Wada T, Makielski JC, Burant CF, McNally EM (July 2002). "Episodic coronary artery vasospasm and ... and deletion of the kir6.2 or sur2 genes leads to coronary artery vasospasm and death. Upon further exploration of sarcKATP's ...

*Sumatriptan

Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular ...

*Cardiac catheterization

... coronary vasospasm) Right heart catheterization, along with pulmonary function testing and other testing should be done to ... It is important to note that the coronary arteries are not accessed during a right heart catheterization. Main page: Coronary ... Subsets of this technique are mainly coronary catheterization, involving the catheterization of the coronary arteries, and ... where it can be maneuvered into the coronary arteries through the coronary ostia. In this position, the interventional ...

*Coronary catheterization

... coronary vasospasm) The patient being examined or treated is usually awake during catheterization, ideally with only local ... A coronary catheterization is a minimally invasive procedure to access the coronary circulation and blood filled chambers of ... Coronary catheterization is one of the several cardiology diagnostic tests and procedures. Specifically, coronary ... that coronary catheterization does not allow the recognition of the presence or absence of coronary atherosclerosis itself, ...

*Dihydroergotamine

DHE and triptans should never be taken within 24 hours of each other due to the potential for coronary artery vasospasm. DHE ...

*List of examples of Stigler's law

Prinzmetal angina: also known as variant angina, referring to angina (chest pain) caused by vasospasm of the coronary arteries ...

*Antianginal

... directly preventing coronary artery vasospasm). They are not used in the treatment of unstable angina . In vitro, they dilate ... Pfister M, Seiler C, Fleisch M, Göbel H, Lüscher T, Meier B (October 1998). "Nitrate induced coronary vasodilatation: ... reducing heart rate and improving coronary blood flow. In vivo, the vasodilation and hypotension trigger the baroreceptor ... the coronary and peripheral arteries and have negative inotropic and chronotropic effects - decreasing afterload, improving ...

*Zolmitriptan

... coronary artery vasospasm, including Prinzmetal's angina, or other significant underlying cardiovascular disease. Zolmitriptan ...

*Sneddon's syndrome

... severe but transient neurological symptoms thought to be caused by cerebral vasospasm, coronary disease and early-onset ... coronary disease and dementia. The skin manifestations may precede the neurologic symptoms by years. Sneddon's syndrome is a ...

*Prinzmetal's angina

Increased alpha-adrenergic receptor activity on epicardial coronary arteries leads to coronary vasospasm. Apart from the ... Coronary revascularization is only useful when the patient shows concomitant coronary atherosclerosis on coronary angiogram. It ... It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel ... The mechanism that causes such intense vasospasm, as to cause a clinically significant narrowing of the coronary arteries is so ...

*Renal angina

Unlike angina pectoris, commonly caused due to ischemia of the heart muscle secondary to coronary artery occlusion or vasospasm ... Like acute coronary syndrome which precedes or is a sign of a heart attack, renal angina is used as a herald sign for a kidney ... revolutionized the survival for acute coronary syndrome (ACS). Without correct context, the performance of troponin for ...

*List of MeSH codes (C14)

... coronary restenosis MeSH C14.280.647.250.290 --- coronary thrombosis MeSH C14.280.647.250.295 --- coronary vasospasm MeSH ... coronary restenosis MeSH C14.907.553.470.250.290 --- coronary thrombosis MeSH C14.907.553.470.250.295 --- coronary vasospasm ... coronary aneurysm MeSH C14.280.647.250.260 --- Coronary Arteriosclerosis MeSH C14.280.647.250.285 --- coronary stenosis MeSH ... coronary aneurysm MeSH C14.907.553.470.250.260 --- Coronary Arteriosclerosis MeSH C14.907.553.470.250.285 --- coronary stenosis ...

*Myocardial bridge

A myocardial bridge occurs when one of the coronary arteries tunnels through the myocardium rather than resting on top of it. ... This condition can cause complications such as vasospasm, angina pectoris, arrhythmia, ventricular tachycardia. Additionally ... Small amounts of myocardial bridging often are undetectable, as the blood usually flows through the coronary while the heart is ... coronary artery bypass surgery, or both. Procedure selection is based on the size of the underlying artery during diastole, the ...
We applaud the authors of "Invasive Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease," 1 who demonstrated an occult coronary abnormality in more than three quarters of these patients. Identifying the underlying abnormality is especially important for potentially life-threatening conditions that are amenable to treatment such as coronary artery spasm. Coronary spasm is associated with myocardial infarction, arrhythmias, and sudden death yet is responsive to calcium channel blockers and nitrates. Surprisingly, as stated in the accompanying editorial,2 no patient had inducible spasm on acetylcholine provocation. This observation warrants closer scrutiny, particularly in relation to the acetylcholine provocation method used.. Intracoronary acetylcholine administration is used to assess the presence of coronary endothelial function and coronary spasm. Its use is ideal, given its very short half-life and established safety record.. Endothelial function studies ...
Symptoms are often very similar to pain associated with a more typical heart attack (development of a blockage in a heart artery). Symptoms often occur at rest, and at night. This is different than typical chest pain associated with heart artery blockages which is more typically experience during exertion.. ...
Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coronary spasm are discussed. ...
Coronary artery spasm is a cause of myocardial infarction with non-obstructive coronary arteries (MINOCA). Coronary spasm may occur spontaneously or in response to prescribed or illicit drugs. Myocardial injury and cardiomyopathies have been reported in association with the use of stimulants in children and adults with attention deficit hyperactivity disorder (ADHD).
In this issue of the Journal, Ong et al. (1) sought to determine the prevalence of coronary spasm in angina patients with angiographically normal coronary arteries. Of 304 patients with stable angina, 144 (47%) had normal coronary arteries or only minimal irregularities (,20% diameter reduction) at coronary angiography. Acetylcholine (ACH) testing was performed in 124 of the 144 patients and provoked coronary spasm in 77 (62%). Thirty-five patients (45%) with constrictor response presented with epicardial spasm (defined as a ≥75% diameter reduction with reproduction of the symptoms of the patient), and 42 patients (55%) presented with microvascular spasm (defined as ischemic electrocardiographic changes with symptom reproduction, but no epicardial spasm). Overall two-thirds of patients undergoing the ACH test presented with abnormal coronary artery vasomotion, a finding that also confirmed the presence of the ischemic syndrome.. The authors are to be congratulated for attempting to determine ...
Definitive diagnosis of coronary artery spasm often begins with a coronary angiogram that is performed with the expectation of finding atherosclerotic narrowing of a heart artery. Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. Two patients had coronary artery disease, and three had angiographically normal coronary arteries.. Acting fast at the first sign of heart attack symptoms can save your life and limit damage to your heart. Whether you have had a heart attack or not, if you feel depressed, tell your doctor. You can even have a silent heart attack, one with no symptoms. The symptoms of a heart attack can vary from person to person. To prevent a heart attack, you will most likely need to make lifestyle changes. The patient may need to be hospitalized to prevent a heart attack.. Without normal blood flow from the coronary arteries the heart becomes lack of oxygen and vital nutrients ...
1. Armstrong PW. Stable ischemic syndromes. In: Topol E. Textbook of Cardiovascular Medicine. Philadelphia: Lippincott Raven Publishers 1998. 2. Chatterjee T, Juelke PD, Thum P et al. Successful brachytherapy of coronary vasospasm. Heart 2003; 89(9): 25. 3. Cheng TO. Clinical implication of the hyperventilation test in the diagnosis of coronary artery spasm. Am J Cardiol 1997; 80: 1647. 4. Gersh BJ, Braunwald E, Bonow BO. Chronic coronary artery disease. In: Braunwald E. Heart Disease. A textbook of cardiovascular medicine. 6th ed. Philadelphia: WB Saunders 2001. 5. Halawa B, Salomon P. Activity of transmembrane calcium transport and levels of endothelin-1 in patients with variant angina. Pol Arch Med Wewn 2000; 104(2): 447-453. 6. Hirano Y, Ozasa Y, Yamamoto T et al. Hyperventilation and cold pressor stress echocardiography for noninvasive diagnosis of coronary artery spasm. J Am Soc Echocardiogr 2001; 14(6): 626-633. 7. Hirano Y, Ozasa Y, Yamamoto T et al. Diagnosis of vasospastic angina by ...
Coronary artery spasm (CAS) is an established cause for anginal chest pain, the cardinal symptom of myocardial ischaemia, in patients with angiographically unobstructed coronary arteries. Evidence from large clinical studies has revealed that about 50% of patients undergoing diagnostic coronary angiography for suspected coronary artery disease (CAD) had either normal or near
Exercise induced ST elevation in patients with previous myocardial infarction may simply indicate left ventricular wall asynergy. ST segment elevation without prior myocardial infarction is a rare condition and is commonly associated with critical coronary artery stenosis.1 Temporary ST segment elevation associated with chest pain is the hallmark of variant (Prinzmetal) angina, and is a consequence of severe coronary spasm. In a way that is not yet fully understood, exercise can induce coronary spasm in patients with variant angina, as demonstrated in small groups of patients subjected to supine bicycle exercise on the cardiac catheterisation table.2DSE is widely performed as a useful diagnostic tool in patients with known or suspected coronary artery disease. Through its inotropic and chronotropic effects, dobutamine increases the myocardial oxygen demand and may induce ischaemia and segmental wall motion abnormality in the presence of significant coronary artery disease. Myocardial ischaemia ...
There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of SUMAVEL® DosePro®. SUMAVEL® DosePro® may cause coronary artery vasospasm (Prinzmetals angina). These types of reactions have occurred in some patients without known CAD. For triptan-naïve patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administrating the first SUMAVEL® DosePro® dose in a medically-supervised setting and performing an electrocardiogram (ECG) immediately following SUMAVEL® DosePro® administration. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of SUMAVEL® DosePro®. Life-threatening arrhythmias have been reported within a few hours following the administration of 5-HT1 agonists. Discontinue SUMAVEL® DosePro® if these disturbances occur. Sensations of tightness, pain, pressure, and heaviness have been ...
The mean oral absolute online bioavailability of sales the maxalt retinal detachment symptoms Tablet is retin about online 45, and how to get retin a retin mean peak plasma concentrations (Cmax) are reached in sales approximately 1-1.5 hours (Tmax). Diagnosis Your health care provider may check the size of sales your sales prostate gland directly by putting a sales gloved finger in your rectum and feeling the back wall of the prostate. You can retin ask your pharmacist or sales doctor for information about maxalt that is written for health professionals. Have shortness of breath or chest pain. If there is evidence of CAD or coronary artery vasospasm, maxalt should not be retin administered see contraindications. This medication may be available under multiple brand names and/or in several different forms. You can place the order online, by mail, online by fax or toll-free over the telephone. Your health care provider will also order blood tests, and possibly a sales urine sample. Free Make Up ...
METHODS AND RESULTS Injury was induced by inflation of a balloon catheter 50 +/- 6% above baseline arterial diameter; dogs were followed for 2 hours before death. Epicardial coronary diameters at arteriography and extent of thrombus deposition at serial histological sections were analyzed in controls (n = 20) and in dogs pretreated with superoxide dismutase (SOD, a superoxide radical scavenger, n = 10); other dogs were pretreated with the hydrogen peroxide scavenger catalase (n = 8), the iron chelator deferoxamine (n = 6), or the hydroxyl radical scavenger 1,3-dimethyl-2-thiourea (n = 9). Angioplasty-induced injury was similar among groups. After angioplasty, control dogs exhibited localized and persistent vessel constriction, which was maximal at the initial 5 minutes (28.9 +/- 6.3% diameter decrease versus baseline). Corresponding arterial diameters of SOD-treated dogs were 24-69% larger (95% confidence interval, p less than 0.001) than controls at 5 minutes and, on average, 32% larger than ...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
Rev Esp Cardiol. 1997 Nov;50(11):808-11. [The placement of a Wiktor stent for the treat ment of vasospastic angina: a case report]. [Article in Spanish] Rodríguez Díez S1, Lázaro R, Ruiz Nodar JM, Enero J, Romero C, Gómez Recio M, Martínez Elbal L.
I am a 43 yo female who had a heart attack. My only risk factor is high bp due to kidney surgery as a child that has been controlled by meds. My EKG indicated damage and I had troponin levels of 6 and ...
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Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (|50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm a
Dr. Stern responded: Yes it can in some. If you are prone to coronary artery spasm, then emotional |a href="/topics/stress" track_data="{
In patients with angina and nonobstructive coronary-artery disease, coexistence of epicardial coronary spasm and increased microvascular resistance (IMR) is associated with worse outcomes, according to Japanese researchers.
how do you think this case could have played out differently? Think very few providers would get their cardiologists to bite on young, intoxicated male c/o chest pain with that initial ekg. Im sure most would write it off to early repol. maybe with serial ekgs or echo, but even then itd be a tough sell. Even more concerning is that we all see quite a few intoxicated and agitated young males/females in the department daily. Similar presentations. Feel as though we are so prone to write it off as demand ischemia, coronary vasospasm, trop leak etc.. in this population ...
how do you think this case could have played out differently? Think very few providers would get their cardiologists to bite on young, intoxicated male c/o chest pain with that initial ekg. Im sure most would write it off to early repol. maybe with serial ekgs or echo, but even then itd be a tough sell. Even more concerning is that we all see quite a few intoxicated and agitated young males/females in the department daily. Similar presentations. Feel as though we are so prone to write it off as demand ischemia, coronary vasospasm, trop leak etc.. in this population ...
PDE5 takes part in many physiological and pathological functions, therefore selective PDE5 inhibitors are potentially useful for a variety of pathologies. At the present, PDE5 inhibitors available on the market have been used for the treatment of erectile dysfunction but, at the same time, are in clinical trials investigating other pathologies such as pulmonary arterial hypertension, coronary vasospasm, benign prostatic hyperplasia etc. This review analyzes the PDE5 inhibitors currently in clinical use, the drugs in clinical trials and the most representative chemical classes published in literature in this last decade ...
Introduction Oral capecitabine is an oral prodrug of 5-fluorouracil that has been integrated into the management of multiple cancer types because of the convenience of administration and its efficacy...
Procardia belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, procardia is useful in treating and preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscles demand for oxygen, and further helps to prevent angina in patients with coronary artery disease ...
Procardia belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, procardia is useful in treating and preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscles demand for oxygen, and further helps to prevent angina in patients with coronary artery disease ...
Your doctor may prescribe medications such as nitroglycerin to relax the coronary arteries, calcium antagonists to guard against coronary artery spasm , or aspirin and other antiplatelet drugs to prevent blood clots in the area of the blockage. If you have a stent, you will have to take blood thinners (such as aspirin) inde?nitely. You will also take an antiplatelet such as clopidogrel at least one month after a bare-metal stent is placed in your artery and two or more years after a drug-eluting stent is placed in your artery. Because of the presence of the metal stent, you should not have magnetic resonance imaging (MRI) for at least 4 weeks with- out checking with your doctor ?rst. But you can go through a metal detector at an airport without a problem.. Restenosis. Restenosis (renarrowing or constriction) can occur in the same area of the blood vessel where your angioplasty was done, often within about 6 months of the original procedure. Although placement of a stent greatly reduces the ...
Jen Woodall wrote: , I strongly believe , that should be recognized in whatever way each person chooses. I always , acknowledge the date (well, close to it--cant always remember the exact , date) of my dx in some way. I know my diagnosis date EXACTLY, and I know exactly when my BGs started to go up, and I know when they went kablooie rapidly. I started to have problems in the summer of 1991; my BGs went kablooie starting on July 28, 1992, and I was officially diagnosed on Aug. 17, 1992 after landing in the hospital with a coronary artery spasm. Then they went back down again, and I was able to maintain on diet and exercise until the summer of 1993; in Sept. 1993, I went to the doc, and my BGs were once again rising rapidly, so she tried increasing doses and different sulfonylureas to no effect. I finally went on insulin on May 12, 1994, and THATs the date I celebrate! Like insulin gave me my life back, and I think THATs worth celebrating -- during my time on diet and orals, I was consistently ...
Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in myocardial ischemia with attendant chest pain and electrocardiographic and hemodynamic changes; it is the primary pathogenetic mechanism in Prinzmetals variant angina and has been found in association with classic angina pectoris and acute myocardial infarction. Diagnosis of coronary artery spasm is firmly made only by coronary angiography. Treatment includes the use of both short- and long-acting nitrates and the slow-channel blocking agents such as verapamil, nifedipine, and perhexiline. ...
TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...
Treatment in the emergency department should focus on frequent evaluation (e.g. every 2 hours) of the patients respiratory status with serial FVC and NIF and intubating promptly at signs of respiratory failure. Sitting the patient upright may help temporize the patients dyspnea while preparing for intubation. Even if not intubated, patients presenting with myasthenic crises will need admission to the ICU. First line therapies include IVIG and plasmapheresis, both of which take several days to reach full clinical effect by removing acetylcholine receptor antibodies from the circulation. High dose glucocorticoid therapy and other immunosuppresants such as azathioprine and cyclosporine can be initiated but are intended as long-term therapies and do not provide any benefit in the emergent setting. Anticholinesterase use, such as pyridostigmine, remains controversial because of the risk of coronary artery vasospasm (resulting in MI) and arrhythmia. A basic infectious workup, including a chest x-ray ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Chest pain following successful percutaneous coronary interventions is a common problem. Although the development of chest pain after coronary interventions may be of benign character, it is disturbing to patients, relatives and hospital staff. Such pain may be indicative of acute coronary artery closure, coronary artery spasm or myocardial infarction, but may also simply reflect local coronary artery trauma. The distinction between these causes of chest pain is crucial in selecting optimal care.Management of these patients may involve repeat coronary angiography and additional intervention. Commonly, repeat coronary angiography following percutaneous transluminal coronary angioplasty (PTCA) in patients with chest pain demonstrates widely patent lesion sites suggesting that the pain was due to coronary artery spasm, coronary arterial wall stretching or was of non-cardiac origin. ...
Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested.. Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies.. So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction. ...
The decades-long research focus on the pathophysiology of coronary artery disease (CAD) has provided insights into sex-specific factors that are uniquely important in the noninvasive diagnosis of myocardial ischemic syndromes in women. Evidence gained from the landmark WISE (Womens Ischemic Syndrome Evaluation) study (1) indicates that the full spectrum of CAD in women extends beyond atherosclerotic stenoses in the epicardial coronary arteries to include dysfunction of the coronary microvasculature and endothelium. Additional conditions contributing to the full pathophysiologic spectrum of acute and chronic ischemic heart disease (IHD) in women include coronary vasospasm and coronary artery dissection which mainly affect the epicardial coronary arteries and often develop in younger women (2). The implications of these diverse conditions are substantial. They create diagnostic challenges and limit the application of traditional testing strategies which, while adequate to detect obstructive ...
Acute coronary syndrome (ACS) refers to acute myocardial ischemia caused by atherosclerotic coronary disease, and includes ST elevation myocardial infarction (STEMI), non-ST elevation MI (NSTEMI), and unstable angina. Cocaine accounts for up to 25% of acute MIs in people ages 18 to 45 years. [9] Qureshi AI, Suri MF, Guterman LR, et al. Cocaine use and the likelihood of nonfatal myocardial infarction and stroke: data from the Third National Health and Nutrition Examination Survey. Circulation. 2001;103:502-506. http://circ.ahajournals.org/content/103/4/502 http://www.ncbi.nlm.nih.gov/pubmed/11157713?tool=bestpractice.com The lifetime risk of nonfatal MI with cocaine use is 7 times the risk in nonusers. In the hour after cocaine is used, the risk of MI is 24 times the baseline risk. It is probably due to cocaine-induced coronary vasospasm and thrombosis, in addition to a direct effect on heart rate and arterial pressure. Cocaine also has direct myocardial toxic properties. [10] Amsterdam EA, ...
Physician researchers suspect that some cases of coronary artery spasm go unrecognized and are incorrectly treated with stents. The good news - there could be a simple fix to eliminate these unnecessary stenting procedures ...
Regularly, hpv warts Regularly, hpv warts probably go away in an instant as well as come met potently without needing to do any scars vs sustained negative effects. Even so , on occasion, so what seems to be a growth stands out as the start of a make of cancer, that is why men and women who are certainly protected from session really needs to be come across by way of medical professional. Repetitive venereal blemishes genuinely harsh peculiar in percocet coronary artery spasm addition to the open healthiness focus. Even while genital hpv warts are easy to remove, the unique trojan viruses the tl901 same consistently functioning. Certain forms of HPV will certainly deliver muscle tissue adjustments to the main uterine cervix of ladies causing recurrent deseases that may possibly mean cervical health problems. The primary recommendation for ladies that has a credibility wonderful penile blemishes is usually to receive the companys health each single only 6 months just for nipple smears to keep ...
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
Hello, Im a 23-year old female. I will start off by telling you when this started and what was happening. It was January of 2005, I had my 2nd child in December of 2004. I started having chest pain at...
The more of these symptoms you have, the more likely it is that youre having a heart attack. Chest pain or pressure is the most common symptom, but some people, especially women, may not notice it as much as other symptoms. You may not have chest pain at all but instead have shortness of breath, nausea, or a strange feeling in your chest or other areas.. ...
A CONTRIBUTION TO THE COMPARATIVE STUDY OF THE ORIGIN OF THE SYMPATHETIC AND THE ADRENALIN-SECRETING SYSTEMS AND OF THE VASCULAR MUSCLES WHICH THEY REGULATE. ...
This syndrome was first described 100 years ago as "pseudoangina"; patients manifested chest pain, and had an abnormal stress test, but had normal coronary arteries by angiography. Kemp et al. coined the term "cardiac syndrome X" in 1973 for this clinical scenario. The incidence is higher in postmenopausal women. The underlying pathophysiology is unclear, but different authors have proposed several mechanisms. Problems with the release of endogenous vasodilators leading to spasm of the coronary arteries could be one of the reasons for this symptom complex. Therefore, women with normal coronaries are sometimes given ergonovine in the cardiac catheterization lab in order to induce coronary artery spasm and reproduce the symptoms. Another reason why these women have chest pain despite normal coronary arteries is due to "microvascular angina"-a disease of small vessels which cannot be seen clearly during cardiac catheterization, as mentioned above. overall prognosis for this group of women patients ...
MYOCARDIAL INFARCTION - death of myocardial muscle cells. - there is lack of oxygen from inadequate perfusion. CAUSES: ATHEROSCLEROSIS INADEQUATE PERFUSION TO MEET METABOLIC DEMANDS EMBOLISM OR THROMBUS CORONARY ARTERY SPASM ASSESMENT: CRUSHING, BURNING, TIGHTNESS OR SQUEEZING SUBSTERNAL PAIN LASTS THE LONGER THAN ANGINAL PAIN, USUALLY LONGER THAN 30 MINS. *IS UNRELIEVED BY REST OR…
Interpretation of coronary angiography data Fig. 15 Reproduction of a portion of a catheterization report from patient described in Fig. 10. This section reports information obtained from coronary angiography. Morphology of stenoses, percent reduction in lumen diameter, and sources of collaterization are reported. A pictorial representation of coronary arterial anatomy also is given. Coronary spasm True coronary spasm is diagnosed at the time of coronary angiography with a provocation test utilizing methylergonovine, acetylcholine, or hyperventilation. Fig. 9a-d). Any or all of these abnormalities may exist in a given patient. Compliance Compliance or distensibility is defined as the ratio of a volume change to the corresponding pressure change or as the slope of the volume-pressure ( V / P) relationship. Elastance or stiffness is the inverse of compliance ( P/ V ). Decreased compliance or increased stiffness is thus defined as an increase in the steepness of the pressure-volume plot (see Fig. ...
The purpose of this case repots are to evaluate the role of ST elevation in aVR lead and to make analysis between both cases. There are some atypical electrocardiogram (ECG) presentations which need prompt management in patient with ischemic clinical manifestation such as ST elevation in aVR lead. In this case study, we report a 68-year old woman with chief symptoms of shortness of breath and chest discomfort. She was diagnosed with cardiogenic shock, with Killip class IV, and TIMI score of 8. The second case is a 57-year-old man with typical chest pain at rest which could not be relieved with nitrate treatment ...
We would like to thank Dr. Ratib and colleagues for taking interest in our recently published article (1). We completely agree and have also shown that coated sheaths reduce radial artery spasm and the discomfort experienced by the patient during transradial procedures. Procedural success rates are high with accumulated experience and improvement in equipment.. In our study, clinical evidence of radial artery spasm was observed in 19% of the patients in the coated group and 39% in the uncoated group. We have used a liberal clinical definition to diagnose spasm and avoided the routine use of vasodilators to abolish its potential impact on our end points. This is consistent with the clinical practice of the investigators. All procedures were performed by experienced radial operators using 6-F sheaths.. Spasm resulted in procedural failure in only 17 (2.1%) cases, and in the majority of cases, the procedure was completed successfully via the contralateral radial artery. As suggested, Dham et al. ...
Ergometrina information about active ingredients, pharmaceutical forms and doses by Biosano Laboratorios, Ergometrina indications, usages and related health products lists
Methyl Ergonovine Maleate Salt 57432-61-8 Precursor and Downstream products, Methyl Ergonovine Maleate Salt Precursor products, Methyl Ergonovine Maleate Salt Downstream products ect.
Multidimensional LC/MS-MS Analysis of Synthetic Cannabinoids in Urine, Plasma, and Edibles. Development and Optimization of an LC-MS/MS Method for Dosage Form of Ergocalciferol (Vitamin D2 ) in Human Plasma . A Study on Perceived Stress among Undergraduate Medical Students of Bahir Dar University, Bahir Bar, North West Ethiopia, 2016: Institutional Based Cross Sectional Study. Usefulness of a Pressure Wire for the Diagnosis of Vasospastic Angina during a Spasm Provocation Test. The Importance of Brain MRI in the Diagnosis of Marchiafava-Bignami Disease. Novel analytical technologies of Quality in the Sheep & Goat Dairy Sector. Diet, Nutritional Status and School Performance of Schoolchildren in the District of Abidjan: Case of Yopougon and Bingerville. Isolation, Identification, and Characterization of the Novel Antibacterial Agent Methoxyphenyl-Oxime from Streptomyces pratensis QUBC97 Isolate. Lymphoma Complicating IBD Immunomodulator Therapy: A Reminder to be Vigilant. Small-Intestinal-Bacterial
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] ,25 kg/m2), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases ...
Anaphylactic reaction rarely manifests such as acute coronary syndrome induced by coronary vasospasm or atheromatous plaque rupture due to some chemical mediators, such as histamine, platelet activating factors, cytokines and others, derived from mast cells degranulation.
Looking for Ergonovine? Find out information about Ergonovine. a uterine stimulant; one of the most common ergot alkaloids. Ergonovine is used in obstetrics in cases of uterine bleeding. It is administered orally in... Explanation of Ergonovine
Nitroglycerin is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris. Nitroglycerin comes in forms of tablets, sprays or patches. Nitroglycerin may be able to be used to help destroy prostate cancer.. Nitroglycerin is used for the treatment of angina[1], acute myocardial infarction[2], severe hypertension[citation needed], and coronary artery spasms due to cocaine[citation needed].. It is useful in decreasing angina attacks, perhaps more so than reversing angina once started, by supplementing blood concentrations of nitric oxide, also called Endothelium-derived relaxing factor, before the structure of NO as the responsible agent was known. This led to the development of transdermal patches of glyceryl trinitrate, providing 24-hour release[3]. However the effectiveness of glyceryl trinitrate is limited by ...
Nitroglycerin is also used medically as a vasodilator to treat heart conditions, such as angina and chronic heart failure. It is one of the oldest and most useful drugs for treating heart disease by shortening or even preventing attacks of angina pectoris. Nitroglycerin comes in forms of tablets, sprays or patches. Nitroglycerin may be able to be used to help destroy prostate cancer.. Nitroglycerin is used for the treatment of angina[1], acute myocardial infarction[2], severe hypertension[citation needed], and coronary artery spasms due to cocaine[citation needed].. It is useful in decreasing angina attacks, perhaps more so than reversing angina once started, by supplementing blood concentrations of nitric oxide, also called Endothelium-derived relaxing factor, before the structure of NO as the responsible agent was known. This led to the development of transdermal patches of glyceryl trinitrate, providing 24-hour release[3]. However the effectiveness of glyceryl trinitrate is limited by ...
Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle with a resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives.. Angina. Diltiazem HCl has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal work loads.. Diltiazem has been shown to be a potent dilator of coronary arteries, both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasms are inhibited by diltiazem.. In animal models, diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. It causes excitation-contraction uncoupling in various myocardial ...
We present the case of a 74 year old patient, hypertensive, dyslipidemic, with a personal history of angina going back several years, with an acute coronary syndrome without ST elevation which occurred in the past year, complicated with residual angina and heart failure symptoms. She is admitted accusing chest pain at rest, ceasing spon-taneously after 10 minutes and dyspnea occurring during medium intensity efforts ...
In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given workload. Studies, primarily in patients with good ventricular function, have not revealed evidence of a negative inotropic effect; cardiac output, ejection fraction, and left ventricular end diastolic pressure have not been affected. Such data have no predictive value with respect to effects in patients with poor ventricular function, and increased heart failure has been reported in patients with preexisting impairment of ventricular function. There are few data on the interaction of diltiazem and beta-blockers in patients with poor ventricular function. Resting heart rate is usually slightly reduced by diltiazem. In hypertensive patients, diltiazem ...
A resting ECG (12 lead) was taken at admission, at inclusion in the study, after 5 to 8, 40 to 50, and 150 to 210 days. Extra ECGs were obtained at recurrence of chest pain during hospitalization, at readmission, or at unscheduled visits to the outpatient department. All patients who were considered stable (i.e., no ECG changes or chest pain at rest during the previous 48 h) were to perform an ET prior to discharge at the earliest five days and at the latest eight days after admission. The ET was performed with the patient sitting on an electrically braked bicycle ergometer starting at 10 to 30 W with repeated load increases of 10 W/min. The test was terminated when limiting symptoms occurred, such as chest pain of a degree 5/10, dyspnea of 5/10, or at exertion degree of 17/20 using the Borg scales (16). The test was also terminated if any of the following occurred: ST depression ≥0.3 mV, fall in systolic blood pressure ,15 mm Hg measured once or 10 mm Hg measured twice with a 1-min interval, ...
Learn more about Variant Angina: Heart Spasms at Redmond Regional Medical Center Whenever most people think of chest pain, they associate it with a heart...
The EEG shows hypsarrhythmia in 66% at onset, and it may be described as typical, evolving or modified, or otherwise. Currently, it is thought that even the nontypical hypsarrhythmia has the same clinical significance as true hypsarrhythmia. The report may describe high amplitude slow waves (1-7 Hz) chaotically mixed with sharp waves and spikes, and an interictal pattern showing hypsarrythmia and/or diffuse slow wave spikes at less than 3Hz and /or a burst suppression pattern ie an abnormal background. If there is some preservation of background it is called modified.. Spasms may occur without an abnormal EEG however this pattern is usually present at some time during the course of the disorder, if only in slow wave sleep ...
BACKGROUND: Little is known about patients admitted with chest pain to inpatient telemetry units directly from an emergency department. METHODS: We analyzed data from 105 consecutive patients who presented with chest pain to an emergency department a
Wyckoff principles at play in todays action: Apex setup (springboard, hinge) VSA individual bar analysis Potential signs of a trend reversal PDF
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... is a chapter in the book, Cardiovascular Medicine, containing the following 18 pages: Stable Coronary Artery Disease, Cocaine-Induced Coronary Vasospasm, Vasospastic Angina, Acute Coronary Syndrome, Acute Coronary Syndrome Immediate Management, Acute Coronary Syndrome Adjunctive Therapy, High Risk Acute Coronary Syndrome Management, Moderate Risk Acute Coronary Syndrome Management, Low Risk Acute Coronary Syndrome Management, Myocardial Infarction Stabilization, Post Myocardial Infarction Evaluation, Post Myocardial Infarction Medications, Cardiac Rehabilitation, Angina Pectoris, Angina Diagnosis, Unstable Angina, Unstable Angina Prognosis, Abnormal Coronary Arteries.
OBJECTIVES: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial artery is its proclivity to spasm. Both papaverine and phenoxybenzamine have been recommended as topical vasodilators in clinical practice. We compared the efficacy of both drugs to prevent radial artery spasm and their ability to preserve endothelial function. METHODS: The ability of both drugs to prevent alpha-adrenoreceptor mediated constriction was tested in vitro in an organ bath in radial artery segments obtained from 20 patients. Vessel viability was determined by potassium (K(+)) constriction, and endothelial function was assessed by observing endothelium-dependent relaxation by a synthetic analogue of acetylcholine, carbachol. RESULTS: Papaverine consistently abolished and prevented spasm for up to a maximum of 30 min in all segments. In contrast, phenoxybenzamine consistently abolished and prevented radial
Patients with symptoms suggestive of an acute myocardial infarction (MI) and having electrocardiographic evidence of an acute MI manifested by ST elevations (>1 mm in two contiguous leads afterto rule out coronary vasospasm) that is considered to rep
Patients with symptoms suggestive of an acute myocardial infarction (MI) and having electrocardiographic evidence of an acute MI manifested by ST elevations (>1 mm in two contiguous leads afterto rule out coronary vasospasm) that is considered to rep
[Coronary Spasm after Administration of Propranolol during Dobutamine Stress Echocardiography]. - Lucía Alvarez, José Zamorano, Luis Mataix, Carlos Almeria, Raúl Moreno, José Luis Rodrigo
Smedema, J. & Muller, G.J. 2008, Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine, South African Medical Journal, vol. 98(5) 372-373, http://www.samj.org.za/index.php/ ...
Treatment of vasospastic disease with prostaglandin E1.: Prostaglandin E1, a vasodilator and potent inhibitor of platelet aggregation, was administered to 26 pa
We conclude that 1) plasma levels of FPA, BTG, and PF4 were increased in patients with variant angina as compared with those with stable exertional angina; 2) there was a significant circadian variation in the plasma levels of FPA in parallel with that of the frequency of the attacks with the peak level occurring from midnight to early morning in patients with variant angina; and 3) elevated levels of plasma FPA are the result and not the cause of coronary spasm ...
The presence of sepsis syndrome has evolved as an independent predictor of poor outcome in patients with high-risk malignancies accompanied by Achromobacter bloodstream infections. FCE 24517-resistant sildenafil generic MCF-7 human breast cancer cell line: selection and characterization. This effect is time dependent and the specific activity of enzyme increases significantly in hormone treated insects.. Neuroprotective, anesthetic, and cardiovascular effects of the NMDA antagonist, CNS 5161A, in isoflurane-anesthetized lambs. The Mini-Mental State Examination was used to identify cognitive impairment. Type I CD36 deficiency associated sildenafil citrate with metabolic syndrome and vasospastic angina: a case report. Effect of free fatty acid concentration on the transport and utilization of other albumin-bound compounds: hydroxyphenylazobenzoic acid. We therefore developed a bioinformatic method for detecting such gene pairs using an integrated analysis of genomic copy number sildenafil 100mg ...
They help reduce the vascular tone, improve nutrition, remove pain. After conducting such measures for the removal of spasm of the vessels of the brain with essential dasg it is extremely important to find out the reason for its occurrence. To do this, you need to undergo a survey that will allow you to find "weak spots" in the body. Further treatment involves a parallel effect on the vessels and the source of problems with them. Causes of spasm may be several. This is a cervical osteochondrosis, and diabetes mellitus, and problems with thyroid gland. Therapeutic measures aimed at the underlying disease reduce the risk of cerebral ischemia. To prevent vascular spasm of the brain, drugs prescribed by a physician allow you to improve blood supply to tissues, preventing the development of a stroke. You can use a point massage to relieve a spastic headache. To do this, you should press the points located in the temporal fossa, on the penis, in the middle of the eyebrows and at their inner corners. ...
Raynauds Phenomenon affects the circulation mainly in the hands and feet. Blood vessels may shrink when hands are exposed to the cold and spasms may occur. At times, fingers and toes may turn white and blue from a lack of oxygen.
Uterus Spasm So, Ive felt baby move already (Im 17 weeks) but about 1 time per day I have what seems to be a muscle spasm on the left side of my mid belly. …
Her finder du det sidste nye om Prinzmetal Variant Angina og det Kardiologiske Syndrom X, samt et debatforum hvor patienter har mulighed for at komme i kontakt med andre i samme situation.
Her finder du det sidste nye om Prinzmetal Variant Angina og det Kardiologiske Syndrom X, samt et debatforum hvor patienter har mulighed for at komme i kontakt med andre i samme situation.
I am having two sererate issuse that may be related. I am 2 1/2 years out from my RNY. I have been buising like crazy on my forearms. Last night I had both thumbs go into spasms at the same time, they constricted and locked down, very wierd, I had a ...
Shop for best quality generic for Stelax, which is used for treating Spasms at our pharmacy for $0.44 per Tablet. You can save more on shopping with us on ordering more than a months supply.
Question - The night before last my rectum went into severe spasms, which - CA. Find the answer to this and other Medical questions on JustAnswer
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Angina pectoris in pregnancy is unusual and Prinzmetals angina is much rarer. It accounts for 2% of all cases of angina. It is caused by vasospasm, but the mechanism of spasm is unknown but has been linked with hyperthyroidism in some studies. Patients with thyrotoxicosis-induced acute myocardial infarction are unusual and almost all reported cases have been associated with Graves disease. Human chorionic gonadotropin hormone-induced hyperthyroidism occurs in about 1.4% of pregnant women, mostly when hCG levels are above 70-80 000 IU/L. Gestational transient thyrotoxicosis is transient and generally resolves spontaneously in the latter half of pregnancy, and specific antithyroid treatment is not required. Treatment with calcium channel blockers or nitrates reduces spasm in most of these patients. Overall, the prognosis for hyperthyroidism-associated coronary vasospasm is good. We describe a very rare case of an acute myocardial infarction in a 27-year-old female, at 9 weeks of gestation due to ...
Cardiac conditions. Certain subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle (myocardium). They are measured in the blood to differentiate between unstable angina and myocardial infarction (heart attack) in patients with chest pain or acute coronary syndrome. A patient who had suffered from a myocardial infarction would have an area of damaged heart muscle and so would have elevated cardiac troponin levels in the blood. This can also occur in patients with coronary vasospasm.. It is important to note that cardiac troponins are a marker of all heart muscle damage, not just myocardial infarction. Other conditions that directly or indirectly lead to heart muscle damage can also increase troponin levels. Severe tachycardia (for example due to supraventricular tachycardia) in an individual with normal coronary arteries can also lead to increased troponins for example, presumably due to increased oxygen demand and inadequate ...
The occurrence of vasospasm can be reduced by preventing the occurrence of atherosclerosis. This can be done in several ways, the most important being lifestyle modifications-decreasing low-density lipoprotein (LDL), quitting smoking, physical activity, and control for other risk factors including diabetes, obesity, and hypertension. Pharmacological therapies include hypolipidemic agents, thrombolytics and anticoagulants. Pharmacological options for reducing the severity and occurrence of ischemic episodes include the organic nitrates classified as having long acting (i.e. isosorbide dinitrate) and short acting (i.e. nitroglycerin) durations of action. These drugs work by increasing nitric oxide levels in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary resistance, allowing for increased oxygen supply to the vital organs (myocardium). The nitric oxide increase in the blood resulting from these drugs also causes dilation of ...
six months ago I had two stents placed in my lad coronary due to severe chest pain (occasional) had no heart attack..since then I am experiencing occasional chest and throat discomfort ..I am taking isosorbide, amlodopine plavix baby asprin and lipitor..I am going crazy with this issue...my doc. says I have coronary spasms and they should have gone away by now...why have they not? I am a 70 year old woman in otherwise good health..non smoker, not heavy and play golf or walk three miles a day for the past 30 years..not high blood p. or high colestoral...after ready the harvard news letter I asked my doc. to test my Lipoprotein level it should be below 20 mine is 247 has anyone else heard of this...my recent understand is that..this should have been looked a long time ago..as it is very dangerous, perhaps more so than hdl or ldl levels????help,,,p.s. the docs have looked into my coronaries and additional 3 times (post stent) and find all things in good order ...
If you are injured in a car accident, it is ideally recommended to go through physical therapy if you noticed any pain/spasm and difficulty in function irrespective of the magnitude. Pain/spasms may appear minimal initially following auto accidents. However, if not given proper care it can transform to a major injury and even result in disability. Your insurance will be able to help you pinpoint the party that is responsible for paying for the therapy. If the accident is deemed as your fault, your insurance company will pay for the therapy up to a certain amount. The exact policy you have will determine what this limit is. If the other person is at fault, then their insurance will cover your physical therapy expenses. Oftentimes, there is a medical expense limit in place, such as $30,000. If your expenses exceed this limit, this doesnt mean the at-fault partys insurance is not going to cover more. In addition to medical expense coverage, the persons insurance will likely offer you some type ...
The permanent vasodilator effect following resection of sympathetic ganglia and trunks, with its subsequent physiologic changes, has stimulated us to find numerous clinical applications of the procedure. Naturally any disease that arises either directly or indirectly from impaired circulation must be considered. The results obtained by interrupting the vasoconstrictor fibers of the peripheral arteries are determined by the dilatation of the arteries and arterioles affected by the operative procedure. Therefore, it is extremely important to select patients who have nonocclusive lesions of the arteries, and who have vasomotor spasm of the arteries which has resulted in impairment of the circulation. ...
Study Design. The double-blind, randomized, placebo-controlled study (Phase 2B) will evaluate both safety and efficacy of dutogliptin in combination with G-CSF as an adjunct treatment for patients with acute myocardial infarction.. Patients being considered for participation in this study are those who have had a large myocardial infarction due to coronary artery atherosclerotic disease within the past 72 hours. After completion of screening procedures, patients will be randomized to receive either dutogliptin in combination with G-CSF or placebo.. ...
Vascular disorders can be classified into five groups: traumatic, compressive, occlusive, tumors/malformations and vasospastic. These problems may occur more commonly in individuals with certain diseases such as diabetes, hypertension, or kidney failure, or in dialysis patients.
The symptoms of a diaphragm spasm include making a sudden gasping sound known as hiccuping and a slight tightening of the chest and throat just prior to making the characteristic hiccup sound. When...
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Studies on patients with angina pectoris and normal coronary angiograms: with special reference to adenosine as a modulator of pain ...
Magnesium IV (Intravenous Infusion):MAGNESIUM is the second most plentiful mineral in the intracellular fluid and the most plentiful cation in the body. Magnesium is involved with more than 300 enzyme systems. The body contains about 25 grams of magnesium, which is divided in roughly equal portions between the skeleton and soft tissue.. Magnesium is used for treating and preventing hypomagnesaemia. It is also used orally as a laxative for constipation and for preparation of the bowel for surgical or diagnostic procedures. Magnesium is also used orally for treating symptoms of asthma and allergic rhinitis; for cardiovascular diseases including angina, arrhythmias, hypertension, coronary heart disease and hyperlipidemia, low high-density lipoprotein (HDL) levels, mitral valve prolapse, vasospastic angina, myocardial infarction, multiple sclerosis; and as an antacid for symptoms of gastric hyperacidity. It is also used orally for treating attention deficit-hyperactivity disorder (ADHD), anxiety, ...
Stiff-person syndrome (SPS) is a rare acquired neurological disorder characterized by progressive muscle stiffness (rigidity) and repeated episodes of painful muscle spasms. Muscular rigidity often fluctuates (i.e., grows worse and then improves) and usually occurs along with the muscle spasms. Spasms may occur randomly or be triggered by a variety of different events including a sudden noise or light physical contact. In most cases, other neurological signs or symptoms do not occur. The severity and progression of SPS varies from one person to another. If left untreated, SPS can potentially progress to cause difficulty walking and significantly impact a persons ability to perform routine, daily tasks. Although the exact cause of SPS is unknown, it is believed to be an autoimmune disorder and sometimes occurs along with other autoimmune disorders ...
BackgroundCerebral vasospasm (CVS) following subarachnoid hemorrhage occurs in up to 70% of patients. Recently, stents have been used to successfully treat CVS. This implies that the force required to expand spastic vessels and resolve vasospasm is lower than previously thought.ObjectiveWe develop a mechanistic model of the spastic arterial wall to provide insight into CVS and predict the forces required to treat it.Material and MethodsThe arterial wall is modelled as a cylindrical membrane using a constrained mixture theory that accounts for the mechanical roles of elastin, collagen and vascular smooth muscle cells (VSMC). We model the pressure diameter curve prior to CVS and predict how it changes following CVS. We propose a stretch-based damage criterion for VSMC and evaluate if several commercially available stents are able to resolve vasospasm.ResultsThe model predicts that dilatation of VSMCs beyond a threshold of mechanical failure is sufficient to resolve CVS without damage to the ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Looking for online definition of carpopedal spasm in the Medical Dictionary? carpopedal spasm explanation free. What is carpopedal spasm? Meaning of carpopedal spasm medical term. What does carpopedal spasm mean?
Patients with chest pain who are admitted to the hospital after an emergency department evaluation with negative findings and nonconcerning vital signs rarely had adverse cardiac events, suggesting that routine inpatient admission may not be a beneficial strategy for this group of patients, according to an article published online by JAMA Internal Medicine.
The results of our prospective study suggest that myocardial bridging of the LAD is very frequent in ABS patients, as revealed both by coronary angiography and mostly by CTA compared with controls. Myocardial bridging is usually considered a congenital coronary anomaly with no hemodynamic relevance, but it has been associated with different clinical scenarios, such as typical or atypical angina and myocardial infarction (9-13). From the pathophysiological point of view, myocardial bridging-related myocardial ischemia may be attributed to a combination of different factors: sudden tachycardia (compromising diastolic filling of coronary arteries); increased contractility; coronary spasm and systolic kinking of the coronary arteries (leading to endothelial damage, platelet activation and thrombosis, or mechanical reduction of the blood flow) (9-13).. The true prevalence of myocardial bridging is not fully known because it is usually underdiagnosed by conventional angiography. CTA should be the ...
2017 Elsevier Inc. Introduction Cardiac abnormalities are observed frequently after aneurysmal subarachnoid hemorrhage (aSAH). A subset of aSAH patients develops neurogenic cardiomyopathy, likely induced by catecholamine excess. Genetic polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been linked to decreased nitric oxide (NO) levels, coronary artery spasm, and myocardial infarction. The role of the eNOS single nucleotide polymorphism (SNP) −786 T/C in cardiac instability following aSAH has not been previously investigated. Methods From 2012 to 2015, aSAH patients were prospectively enrolled in the Cerebral Aneurysm Renin Angiotensin System (CARAS) study at two academic institutions. Blood samples were used to assess the eNOS SNP -786 T/C rs2070744 through 5exonuclease (Taqman) genotyping assays. Associations between this polymorphism and cardiac instability following aSAH were analyzed. Results Multivariable analysis demonstrated a dominant effect of the C allele of ...

Pathogenesis of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage: Putative Mechanisms and Novel Approaches -...Pathogenesis of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage: Putative Mechanisms and Novel Approaches -...

Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage ( ... Coronary vasospasm is characterized by focal or diffuse spasm of an epicardial coronary artery. Definitive diagnosis is usually ... Spontaneous Coronary Vasospasm Due to Polytrauma D Huynh et al. Trauma Case Rep 21, 100194. 2019. PMID 31049387. - Case Reports ... Delayed Cerebral Vasospasm and Nitric Oxide: Review, New Hypothesis, and Proposed Treatment RM Pluta. Pharmacol Ther 105 (1), ...
more infohttps://pubmed.ncbi.nlm.nih.gov/18709660/

Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a...Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a...

... on vasospasm and the expression of the ETA receptor messenger ribonucleic acid (mRNA) using a canine two-hemorrhage SAH model. ... 1 and the ETA receptor in the pathogenesis of delayed cerebral vasospasm following subarachnoid hemorrhage (SAH). A study was ... The results suggest that endothelin-1 and the ETA receptor participate in the pathogenesis of delayed cerebral vasospasm ... Coronary Vasospasm. Coronary vasospasm is the abnormal contraction of the coronary arteries on the epicardium. The constriction ...
more infohttps://www.meta.org/papers/prevention-of-delayed-vasospasm-by-an-endothelin/7931624

A Case of Coronary Vasospasm after Repeat Rituximab InfusionA Case of Coronary Vasospasm after Repeat Rituximab Infusion

... Calvin Ke,1 Amit Khosla,2 Margot K. Davis,2 Cameron Hague,3 and ... Coronary artery vasospasm (CAV) can be triggered by medication reactions. CAV occurring after multiple exposures to rituximab ... Angiogram revealed evidence of coronary vasospasm. The patient was successfully treated with amlodipine. This case underlines ...
more infohttps://www.hindawi.com/journals/cric/2015/523149/abs/

Coronary vasospasm - WikipediaCoronary vasospasm - Wikipedia

Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes occlusion (stoppage) or ... "Multivessel coronary vasospasm mimicking triple-vessel obstructive coronary artery disease". J Invasive Cardiol. 19 (7): E178- ... Hibino H, Kurachi Y (March 2006). "A new insight into the pathogenesis of coronary vasospasm". Circ. Res. 98 (5): 579-81. doi: ... Miwa K, Ishii K, Makita T, Okuda N (May 2004). "Diagnosis of multivessel coronary vasospasm by detecting postischemic regional ...
more infohttps://en.wikipedia.org/wiki/Coronary_vasospasm

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. | CirculationEvidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. | Circulation

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.. F R Laurindo, P L da Luz, L ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ... Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. ...
more infohttp://circ.ahajournals.org/content/83/5/1705

Coronary vasospasm and concurrent Takotsubo cardiomyopathy | The British Journal of CardiologyCoronary vasospasm and concurrent Takotsubo cardiomyopathy | The British Journal of Cardiology

... to exclude coronary vasospasm. Further study and analysis is required to investigate the association of coronary vasospasm as a ... Figure 2. Right coronary angiography. A: initial coronary angiography revealed a dominant right coronary artery (RCA) with a ... Right radial artery access coronary angiography revealed a normal left coronary system. The right coronary artery was the ... These findings suggest that coronary artery vasospasm may have contributed to the aetiology in this case of TTC. This case adds ...
more infohttps://bjcardio.co.uk/2019/02/coronary-vasospasm-and-concurrent-takotsubo-cardiomyopathy/

Coronary Vasospasm and Coronary Atherosclerosis | JACC: Journal of the American College of CardiologyCoronary Vasospasm and Coronary Atherosclerosis | JACC: Journal of the American College of Cardiology

Coronary Vasospasm and Coronary Atherosclerosis Message Subject (Your Name) has forwarded a page to you from JACC: Journal of ... 1980) Some clinical considerations regarding the relation of coronary vasospasm to coronary atherosclerosis: a hypothetical ... Coronary artery spasm-related acute coronary syndrome in patients with coexisting spasm of angiographically normal coronary ... 1990) Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81:491-497. ...
more infohttp://www.onlinejacc.org/content/59/7/663

Acute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? A case reportAcute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? A case report

... Przybojewski, J. Z. ... Acute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? A case report . S Afr Med J, 66(10 ... Ergometrine maleate provocation on this occasion failed to demonstrate any coronary vasospasm. Possible pathophysiological ... Cardiac catheterization a further 4 months later documented no further filling defect in the LAD branch and the coronary ...
more infohttp://scholar.sun.ac.za/handle/10019.1/7539

Acute coronary vasospasm secondary to industrial nitroglycerin withdrawal :  a case presentation and reviewAcute coronary vasospasm secondary to industrial nitroglycerin withdrawal : a case presentation and review

Acute coronary vasospasm secondary to industrial nitroglycerin withdrawal : a case presentation and review. Przybojewski, J. Z. ... We postulate that this patients clinical features were a direct result of severe vasospasm affecting the left coronary artery ... also strongly suggested that withdrawal from contact with industrial NG precipitated this potentially lethal coronary vasospasm ... An ergonovine (ergometrine) maleate provocative test failed to elicit coronary artery spasm, although this was undertaken while ...
more infohttp://scholar.sun.ac.za/handle/10019.1/7592

KAKEN - Research Projects | Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel...KAKEN - Research Projects | Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel...

Coronary microcirculation / coronary vasospasm / endothelial injury / endothelin / RhoA / ヘンドセリン / 攣縮 / アセチルコリン. ... Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel porcine model.. Research Project ... ET-1 plays a crucial role for coronary microvascular spasm and the blockade of ET-1 may be beneficial for treating coronary ... Journal Article] Repeated epicardial coronary artery endothelial injuries lead to a global spontaneous coronary artery spasm ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590762/

Coronary vasospasm | Health And WellnessCoronary vasospasm | Health And Wellness

Table of Contents: 00:02 - Acute Coronary Syndrome: Angina 00:15 - Acute Coronary Syndromes (ACS) 00:27 - Angina Pectoris 01:49 ... Vasospasm Turns Pink women health center, women health care, women health clinic, women s health program, centers of disease ... The animation shows how plaque buildup or a coronary artery spasm can lead to a heart attack and how blocked blood flow in a ... Raynauds Phenomenon (vasospasm in extremities) http://usmlefasttrack.com/?p=1566 Raynaud, s, Phenomenon, vasospasm, in, ...
more infohttp://healthandwellness.me/category/coronary-vasospasm/

Coronary Artery Vasospasm - Prinzmetals Angina - Cardiology - Highland Hospital - University of Rochester Medical CenterCoronary Artery Vasospasm - Prinzmetal's Angina - Cardiology - Highland Hospital - University of Rochester Medical Center

Coronary Artery Vasospasm or Prinzmetals Angina Chest pain/discomfort caused by muscle spasm of the muscle within the walls of ... A cardiac stress test or angiogram are often required to rule out significant blockages in the coronary arteries ...
more infohttps://www.urmc.rochester.edu/highland/departments-centers/cardiology/conditions/coronary-artery-vasospasm.aspx

HKU Scholars Hub: Mechanisms responsible for coronary vasospasmHKU Scholars Hub: Mechanisms responsible for coronary vasospasm

Patients with coronary artery spasm usually have morphologic changes in the artery at the site of the spasm. Thus, platelets ... Patients with coronary artery spasm usually have morphologic changes in the artery at the site of the spasm. Thus, platelets ... segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. ... segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. ...
more infohttp://hub.hku.hk/handle/10722/170810

Coronary vasospasm complicating cannabinoid hyperemesis syndrome

 | DIAL.pr - BOREALCoronary vasospasm complicating cannabinoid hyperemesis syndrome | DIAL.pr - BOREAL

Coronary vasospasm complicating cannabinoid hyperemesis syndrome. In: Journal of Cardiology Cases, Vol. 15, no.4, p. 115-118 ( ... However, the patient was readmitted very soon with a ST-elevation myocardial infarction related to coronary vasospasm. While ... the possibility of some serious cardiac event should not be neglected as cannabis seems also able to trigger coronary vasospasm ... Acute coronary syndrome ; Cannabinoid hyperemesis syndrome ; Cannabis ; Vasospasm Links. :. * [Handle]. http://hdl.handle.net/ ...
more infohttps://dial.uclouvain.be/pr/boreal/object/boreal:184311

Transient Coronary Vasospasm in a Newborn Due to Maternal Cannabis Use during Pregnancy | AbstractTransient Coronary Vasospasm in a Newborn Due to Maternal Cannabis Use during Pregnancy | Abstract

... thus they are known to cause MI secondary to coronary vasospasm. Here we showed that transient coronary vasospasm in a new born ... Transient Coronary Vasospasm in a Newborn Due to Maternal Cannabis Use during Pregnancy ... If necessary a coronary angiography should design to evaluate coronary arteries.. Author(s): Huseyin Avni Solgun and Isa ... Cannabis use during pregnancy can induce transient coronary vasospasm and ischemia in new born. These patients should be ...
more infohttp://criticalcare.imedpub.com/abstract/transient-coronary-vasospasm-in-a-newborn-due-to-maternal-cannabis-use-during-pregnancy-24030.html

Coronary Artery Vasospasm Article - StatPearlsCoronary Artery Vasospasm Article - StatPearls

Coronary Artery Vasospasm. Introduction. Coronary artery vasospasm (CAVS) is a constriction of the coronary arteries that can ... Takeyoshi D,Kikuchi S,Miyake K,Tatsukawa T,Kobayashi D,Uchida D,Kitani Y,Kamiya H,Azuma N, Fatal Vasospasm of the Coronary ... However, some of these patients return to vasospasm in another location. Thus, coronary stenting with long-term medical therapy ... Close monitoring is required because recurrence of coronary vasospasm is common, which in some patients can prove fatal. (Level ...
more infohttps://statpearls.com/kb/viewarticle/20017/

Acute ST-Segment Elevation Due to Coronary Vasospasm After Cefuroxime Induced Anaphylactic Shock
							| Hospital Chronicles
	...Acute ST-Segment Elevation Due to Coronary Vasospasm After Cefuroxime Induced Anaphylactic Shock | Hospital Chronicles ...

Acute ST-Segment Elevation Due to Coronary Vasospasm After Cefuroxime Induced Anaphylactic Shock * Nikolaos Laschos NIMTS ... Keywords: acute coronary syndromes, allergic reaction, Kunis syndrome Abstract. A 41-year-old patient presented to the ... The connection between acute coronary syndromes and anaphylaxis seems to be strong. The same mediators released during acute ... allergic reactions are increased in blood or urine of patients suffering from acute coronary syndromes of non allergic etiology ...
more infohttp://hospitalchronicles.gr/index.php/hchr/article/view/463

Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome by Jonathan Hullman, MS4, Jaehee..."Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome" by Jonathan Hullman, MS4, Jaehee...

... of inflammatory mediators such as histamine and cytokines by mast cells and eosinophils resulting in either coronary vasospasm ... INTRODUCTION Kounis syndrome is an acute coronary syndrome occurring secondary to an anaphylactic reaction. A wide variety of ... Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome ... "Allergic Inflammatory Mediated Coronary Artery Vasospasm: A Case Report of Kounis Syndrome," The Medicine Forum: Vol. 17 , ...
more infohttps://jdc.jefferson.edu/tmf/vol17/iss1/4/

Interesting presentation of Kounis syndrome secondary to amoxicillin/clavulanate use: Coronary vasospasm and simultaneous...Interesting presentation of Kounis syndrome secondary to amoxicillin/clavulanate use: Coronary vasospasm and simultaneous...

Interesting presentation of Kounis syndrome secondary to amoxicillin/clavulanate use: Coronary vasospasm and simultaneous ... Interesting presentation of Kounis syndrome secondary to amoxicillin/clavulanate use: Coronary vasospasm and simultaneous ... Keywords: Amoxicillin/clavulonate, Kounis syndrome, vasospasm.. How to cite this article. U ur Canpolat, Duygu Ko yi it, Kudret ... Kounis syndrome (KS) is defined as concurrent acute coronary syndrome and allergic or hypersensitivity reactions. Despite being ...
more infohttp://archivestsc.com/jvi.aspx?pdir=tkd&plng=eng&un=TKDA-38845&look4=

The Significance of Vasospasm in Stable Coronary Artery Disease - American College of CardiologyThe Significance of Vasospasm in Stable Coronary Artery Disease - American College of Cardiology

Coronary Angiography, Coronary Artery Disease, Coronary Vasospasm, Drug-Eluting Stents, Electrocardiography, Ergonovine, Heart ... The Significance of Vasospasm in Stable Coronary Artery Disease. Aug 27, 2015 , ; Dr. Udo P. Sechtem, MD, FACC Expert Analysis ... Angiographic and clinical characteristics of patients with acetylcholine-induced coronary vasospasm on follow-up coronary ... A tendency for coronary vasospasm seems to be rather common in patients with chronic stable angina irrespective of the degree ...
more infohttps://www.acc.org/latest-in-cardiology/articles/2015/08/13/13/46/the-significance-of-vasospasm-in-stable-coronary-artery-disease

Coronary artery vasospasm: description, causes and risk factorsCoronary artery vasospasm: description, causes and risk factors

Coronary artery vasospasm is an important cause of chest pain syndromes that can lead to myocardial infarction, ventricular ... Coronary artery vasospasm - Description, Causes and Risk Factors:. Coronary artery vasospasm, or smooth muscle constriction of ... Coronary artery vasospasm occurs most commonly in people who smoke or who have high cholesterol or high blood pressure. It may ... Coronary artery vasospasm - Symptoms:. This variant of angina occurs at rest, usually lasting for between 5 and 30 minutes. ...
more infohttps://www.medigoo.com/articles/coronary-artery-vasospasm/

Multifocal Severe Coronary Artery Vasospasm Mistaken for Diffuse Atherosclerosis: A Case ReportMultifocal Severe Coronary Artery Vasospasm Mistaken for Diffuse Atherosclerosis: A Case Report

... Sarfraz Ahmed Nazir, 1 ,* Sheraz ... Coronary artery vasospasm can cause a transient, abrupt, and marked decrease in the diameter of an epicardial coronary artery. ... Multivessel coronary artery vasospasm was now considered and intra-coronary nitroglycerin given. This induced relief of chest ... Multifocal Severe Coronary Artery Vasospasm Mistaken for Diffuse Atherosclerosis: A Case Report. Multifocal Severe Coronary ...
more infohttp://prinzmetal.org/contents/en-us/d123_Multifocal_Severe_Coronary_Artery_Vasospasm_Mistaken_for_Diffuse_Atherosclerosis__A_Case_Report.html

Current Issue : Coronary Artery DiseaseCurrent Issue : Coronary Artery Disease

Coronary Vasospasm Decreased resting coronary flow and impaired endothelial function in patients with vasospastic angina. Saito ... Pulse pressure correlates with coronary artery calcification and risk for coronary heart disease: a study of elderly ... Primary percutaneous coronary intervention in ST-elevation myocardial infarction with an ectatic infarct-related artery. ... Long-term clinical outcomes after a percutaneous coronary intervention with a drug-eluting stent in patients with unprotected ...
more infohttps://journals.lww.com/coronary-artery/Pages/currenttoc.aspx

JCI -
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channelsJCI - Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels. ... Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels. ...
more infohttps://sdjiaheng.net.insight.mobile.jci.org/articles/view/15672/figure/1

The ST segment - Life in the Fast Lane ECG LibraryThe ST segment - Life in the Fast Lane ECG Library

Coronary Vasospasm (Prinzmetals angina). *This causes a pattern of ST elevation that is very similar to acute STEMI - i.e. ... Widespread ST depression with ST elevation in aVR is seen in left main coronary artery occlusion and severe triple vessel ...
more infohttps://lifeinthefastlane.com/ecg-library/st-segment/
  • Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). (nih.gov)
  • The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorly understood. (nih.gov)
  • The combination of novel approaches such as cerebral microdialysis, magnetic resonance spectroscopy, proteomics, and lipidomics could serve a dual purpose: elucidating the complex pathobiochemistry of vasospasm and providing clinicians with tools for early detection of this feared complication. (nih.gov)
  • The purpose of this Mini-Review is to provide an overview of the pathogenesis of cerebral vasospasm and of novel approaches used in basic and translational research. (nih.gov)
  • Despite years of research, delayed cerebral vasospasm remains the feared complication of a ruptured intracranial aneurysm. (nih.gov)
  • It appears that the breakdown products of blood in the subarachnoid space are involved, through direct and/or indirect pathways, in the development of vasospasm after SAH. (nih.gov)
  • Considering the disconnect between the coronary and ventriculogram findings, a decision was made to delay percutaneous coronary intervention (PCI). (bjcardio.co.uk)
  • A decision was made to defer percutaneous coronary intervention (PCI) of the mid-PLV lesion, as a possible complication, such as no reflow or dissection, may lead to worsening of left ventricular function and put the patient at risk of cardiogenic shock and ventricular arrhythmias. (bjcardio.co.uk)
  • Myocardial no reflow after percutaneous coronary intervention (PCI) is associated with poor outcome. (yasni.com)
  • who described findings from ambulatory ECG recordings and exercise testing following intravenous ergonovine application in patients with a chronic total occlusion who had no other coronary lesions. (acc.org)
  • One-third of patients have normal coronary vasculature, and these pose a significant therapeutic dilemma as lack of clinical suspicion might potentially lead to unnecessary revascularization therapies. (prinzmetal.org)
  • Repeat angiogram of the mid-PLV after a short period of medical therapy revealed no coronary lesion and the left ventricular function had normalised. (bjcardio.co.uk)
  • Preliminary data suggest a potential role for hyperventilation and cold-pressor stress echocardiography as a noninvasive means for detecting coronary artery vasospasm, though this method may not be as sensitive as using intracoronary acetylcholine as the provocative agent. (medigoo.com)
  • This induced relief of chest pain marked attenuation of all visible coronary stenoses (Figures 2(c) - 2(d) ) and resolution of ST segment elevation. (prinzmetal.org)
  • While most patients usually complain of recurrent epigastric or periumbilical pain with negative investigations, the possibility of some serious cardiac event should not be neglected as cannabis seems also able to trigger coronary vasospasm in patients presenting with atypical pain or electrocardiographic changes. (uclouvain.be)
  • 3 Moreover, a negative non-invasive stress test does not rule out the possibility of a functional coronary vasomotor disorder as a cardiac cause for the clinical presentation. (acc.org)
  • 10,11,12 Vasomotion disorders of the small coronary vessels were demonstrated more than 20 years ago by Pupita et al. (acc.org)
  • Nevertheless, coronary vessels smooth muscle hypertonicity and reactivity play a pivotal role in the development of CAVS. (statpearls.com)
  • Histological analysis revealed that ET_A antagonist suppressed the downstream vascular remodeling induced by repeated ED. ET-1 plays a crucial role for coronary microvascular spasm and the blockade of ET-1 may be beneficial for treating coronary vasospasm. (nii.ac.jp)
  • Studies have been conducted on isolated segments of the left circumflex coronary artery of the dog to gain information on the mechanism or mechanisms of vasospasm. (hku.hk)
  • Pathophysiology and therapeutic strategy of coronary vasospasm of microvessels using a novel porcine model. (nii.ac.jp)