Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Formation and development of a thrombus or blood clot in the blood vessel.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The formation or presence of a blood clot (THROMBUS) within a vein.
The circulation of blood through the CORONARY VESSELS of the HEART.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.
A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Narrowing or constriction of a coronary artery.
An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Spasm of the large- or medium-sized coronary arteries.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
Elements of limited time intervals, contributing to particular results or situations.
Disease having a short and relatively severe course.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Agents that prevent clotting.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Radiographic visualization or recording of a vein after the injection of contrast medium.
Formation or presence of a blood clot (THROMBUS) in the SUPERIOR SAGITTAL SINUS or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, CRANIOCEREBRAL TRAUMA; and NEUROSURGICAL PROCEDURES. Clinical features are primarily related to the increased intracranial pressure causing HEADACHE; NAUSEA; and VOMITING. Severe cases can evolve to SEIZURES or COMA.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein.
A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
DEEP VEIN THROMBOSIS of an upper extremity vein (e.g., AXILLARY VEIN; SUBCLAVIAN VEIN; and JUGULAR VEINS). It is associated with mechanical factors (Upper Extremity Deep Vein Thrombosis, Primary) secondary to other anatomic factors (Upper Extremity Deep Vein Thrombosis, Secondary). Symptoms may include sudden onset of pain, warmth, redness, blueness, and swelling in the arm.
Pathologic deposition of calcium salts in tissues.
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
The return of a sign, symptom, or disease after a remission.
Bleeding or escape of blood from a vessel.
Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.
Veins draining the cerebrum.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Drugs used to cause dilation of the blood vessels.
Obstruction of flow in biological or prosthetic vascular grafts.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
The hollow, muscular organ that maintains the circulation of the blood.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections (OTITIS MEDIA or MASTOIDITIS) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; NEUROSURGICAL PROCEDURES; THROMBOPHILIA; and other conditions. Clinical features include HEADACHE; VERTIGO; and increased intracranial pressure.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Pressure, burning, or numbness in the chest.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
The degree to which BLOOD VESSELS are not blocked or obstructed.

Intravenous magnesium reduces infarct size after ischemia/reperfusion injury combined with a thrombogenic lesion in the left anterior descending artery. (1/1009)

Experimental studies have demonstrated that intravenous magnesium (Mg) can protect the ischemic myocardium and has an antithrombotic effect. In patients with myocardial infarction, the reperfusion injury is complicated by the presence of a thrombogenic area in the affected coronary artery that may cause repetitive thrombus formation and embolization. We investigated the effect of Mg on infarct size in a randomized study in pigs. Myocardial infarction was induced by a 50-minute mechanical occlusion of the left anterior descending artery combined with an arterial injury, which stimulated a dynamic thrombus formation with emboli shedding on reperfusion. Magnesium sulfate (6 mmol/20 min plus 3 mmol/h) or saline was started at 30 minutes after coronary occlusion. Real-time ventricular pressure-volume loops were generated from the left ventricle by using a microtip pressure manometer and a conductance catheter. Platelet accumulation in the myocardium was evaluated by using 111In-labeled platelets. After 4 hours of reperfusion, the infarct size/area at risk ratio in the placebo group was 46+/-0.06% (n=8) compared with 22+/-0.07% (n=6) in the Mg-treated animals (P=0. 03). Ejection fraction decreased significantly in the control group but not in the Mg-treated animals (P=0.03). Platelet accumulation in the myocardium did not change significantly between the Mg- and placebo-treated animals (placebo group, 191+/-19%; Mg group, 177+/-29%; NS). The present study demonstrates that intravenous Mg infusion is able to reduce infarct size by >50% and preserve the ejection fraction in this model where ischemia/reperfusion injury was evaluated in the presence of a thrombogenic area in the nutrient artery.  (+info)

A role for changes in platelet production in the cause of acute coronary syndromes. (2/1009)

Platelets are heterogeneous with respect to their size, density, and reactivity. Large platelets are more active hemostatically, and platelet volume has been found to be increased both in patients with unstable angina and with myocardial infarction. Furthermore, platelet volume is a predictor of a further ischemic event and death when measured after myocardial infarction. Platelets which are anucleate cells with no DNA are derived from their precursor, the megakaryocyte. Therefore, it is suggested that changes in platelet size are determined at thrombopoiesis in the megakaryocyte and that those changes might precede acute cardiac events. Understanding of the signaling system that controls platelet production may also further elucidate the cascade of events leading to acute vascular occlusion in some patients.  (+info)

Endothelial injuries of coronary arteries distal to thrombotic sites: role of adhesive interaction between endothelial P-selectin and leukocyte sialyl LewisX. (3/1009)

Intracoronary thrombus formation is associated with epicardial vasoconstriction distal to the thrombotic site. To investigate the mechanisms of abnormal vasomotor function of the artery distal to the thrombotic site, we studied coronary vessels in dogs with cyclic flow variations (CFVs) of the left anterior descending coronary artery (LAD) stenosis with endothelial injury. Coronary rings isolated from the LAD (proximal, stenotic, and distal sites) and control circumflex coronary arteries were tested for responsiveness to endothelium-dependent (acetylcholine and A23187) and endothelium-independent vasodilators (NaNO2). Endothelium-independent relaxation was intact in all 4 sites. Endothelium-dependent relaxation was intact in the control and proximal sites and impaired in the stenotic sites. Relaxations not only to acetylcholine and A23187 but also to serotonin, ADP, and thrombin were impaired in the distal sites after observing CFVs for 80 minutes. Electron microscopy revealed the loss of endothelial integrity with leukocyte adherence to the endothelium in the distal sites. Immunohistochemical expression of P-selectin on the endothelial cells was more upregulated in the distal site than in the proximal site, and P-selectin mRNA expression was significantly greater in the ischemic region distal to the thrombotic site than in the proximal nonischemic region. PB1.3, a neutralizing monoclonal antibody against P-selectin, and sialyl LewisX (SLeX)-containing oligosaccharide SLeX, a carbohydrate analogue of selectin ligand, preserved endothelial function without affecting CFVs. SLeX-containing oligosaccharide preserved endothelial integrity of the distal site and inhibited P-selectin expression of the distal site. Thus, the adhesive interaction between endothelial P-selectin and leukocyte SLeX may play an important role in endothelial injuries of the coronary artery distal to the thrombotic site.  (+info)

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (4/1009)

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monkeys, 300 microgram/kg bolus plus 12 microgram/kg/min and 300 microgram/kg bolus plus 30 microgram/kg/min L-374,087 i.v. infusions significantly reduced jugular vein thrombus extension, with both regimens limiting venous thrombus extension to 2-fold that of baseline thrombus mass compared with a 5-fold extension observed in the vehicle control group. Antithrombotic efficacy in the rhesus with the lower-dose regimen was achieved with 2.3- to 2.4-fold increases in aPTT and prothrombin time. In a conscious instrumented dog model of electrolytic vessel injury, the oral administration of two 10 mg/kg L-374,087 doses 12 h apart significantly reduced jugular vein thrombus mass, reduced the incidence of and delayed time to occlusive coronary artery thrombosis, and significantly reduced coronary artery thrombus mass and ensuing posterolateral myocardial infarct size. Antithrombotic efficacy in the dog was achieved with 1.6- to 2.0-fold increases in aPTT at 1 to 6 h after oral dosing with L-374,087. These results indicate significant antithrombotic efficacy against both venous and coronary arterial thrombosis with L-374,087 with only moderate elevations in aPTT or prothrombin time. The oral efficacy of L-374,087 characterizes this compound as a prototype for the further development of orally active direct thrombin inhibitors.  (+info)

Lipoprotein(a) and coronary thrombosis and restenosis after stent placement. (5/1009)

OBJECTIVES: The objective of this prospective study was to evaluate the relation between high lipoprotein(a) levels and thrombotic and restenotic events after coronary stent implantation. BACKGROUND: Lipoprotein(a) may promote atherogenesis, coronary thrombosis and restenosis after balloon angioplasty, but the clinical significance remains unclear. METHODS: The study included 2,223 consecutive patients with successful coronary stent placement. According to the serum level of lipoprotein(a), patients were divided in two groups: 457 patients of the highest quintile formed the high lipoprotein(a) group, and 1,766 patients of the lower four quintiles formed the low lipoprotein(a) group. Primary end points were the incidence of angiographic restenosis at six months and the event-free survival at one year. Secondary end point was the incidence of angiographic stent occlusion. RESULTS: Early stent occlusion occurred in four of the 457 patients (0.9%) with high and 37 of the 1,766 patients (2.1%) with low lipoprotein(a) levels, odds ratio of 0.41 (95% confidence interval, 0.15 to 1.16). Angiographic restenosis occurred in 173 of the 523 lesions (33.2%) in the high lipoprotein(a) group and 636 of the 1,943 lesions (32.7%) in the low lipoprotein(a) group, odds ratio of 1.02 (0.83 to 1.25). The probability of event-free survival was 73.0% in the high lipoprotein(a) group and 74.8% in the low lipoprotein(a) group (p = 0.45). On the basis of the findings in the low lipoprotein(a) group, the power of this study to detect a 25% increase in the incidence of restenosis and adverse events in the group with elevated lipoprotein(a) was 90% and 75%, respectively. CONCLUSIONS: Elevated lipoprotein(a) levels did not influence the one-year clinical and angiographic outcome after stent placement. Thrombotic events and measures of restenosis were not adversely affected by the presence of high lipoprotein(a) levels.  (+info)

Antithrombin activity during the period of percutaneous coronary revascularization: relation to heparin use, thrombotic complications and restenosis. (6/1009)

OBJECTIVES: This study evaluated changes in antithrombin (AT) activity around the time of percutaneous transluminal coronary revascularization (PTCR) with unfractionated heparin anticoagulation and the effects these changes had on major thrombotic complications of PTCR. BACKGROUND: Heparin is used during PTCR to prevent thrombosis. However, heparin, a cofactor for AT, causes AT activity to fall. AT activity <70% is associated with thrombosis. There is a prothrombotic state after heparin discontinuation that has not been well explained. METHODS: Antithrombin activity was sampled at the start and end of PTCR and the next two mornings in 250 consecutive patients. We recorded occurrence of major thrombotic events, defined as 1) major thrombotic complications of PTCR; 2) major in-lab thrombus formation; or 3) subacute occlusion. Discriminant analysis was employed to evaluate the relationship of AT activity to these events. Change in AT activity and its relationship to heparin was evaluated. Evidence of restenosis at six months was obtained. RESULTS: There were 14 major thrombotic events. Antithrombin activity <70% was strongly (p = 0.006) associated with these events. The AT activity fell significantly through the morning after PTCR when 21% of patients had AT activity <70%; AT activity did not normalize until >20 h after heparin discontinuation. Pre-PTCR use of heparin led to lower AT activity in proportion to duration of heparin use. There was no relationship between AT activity and restenosis. CONCLUSIONS: Low AT activity may contribute to major thrombotic complications of PTCR. The way heparin is used before and after PTCR is important to development of low AT activity.  (+info)

Pravastatin therapy in hyperlipidemia: effects on thrombus formation and the systemic hemostatic profile. (7/1009)

OBJECTIVES: The study sought to determine the effects of lipid-lowering with pravastatin on the systemic fibrinolytic profile and on thrombus formation under dynamic flow conditions. BACKGROUND: Lowering cholesterol (C) decreases clinical events in coronary artery disease (CAD) patients, but an analysis of the effects of lipid-lowering on the entire hemostatic and thrombotic profile has not been conducted. METHODS: We prospectively studied 93 stable patients with untreated low-density lipoprotein cholesterol (LDL-C) >145 mg/dl. The CAD patients received pravastatin, and non-CAD patients were randomized to pravastatin versus placebo (double-blind). Thrombus formation upon an injured vascular surface was assessed in a substudy of 40 patients with a previously validated ex vivo perfusion chamber system. Systemic hemostatic markers and thrombus formation were evaluated at baseline, three and six months. RESULTS: Placebo produced no changes in either the lipid profile, any of the hemostatic markers, or the ex vivo thrombus formation. Both pravastatin groups (CAD and non-CAD) showed decreased LDL-C by 30% within 6 weeks (188 to 126 mg/dl, p < 0.001 vs. baseline), and decreased plasminogen activator inhibitor-1 at 3- and 6-month follow-up compared to baseline (15% to 18% decrease at 3 months and 21% to 23% at 6 months). For the tissue plasminogen activator antigen, CAD and non-CAD groups showed significant decreases at 6 months compared to baseline (10% and 13%, respectively). No significant changes were observed with treatment in d-dimer, fibrinopeptide A, prothrombin fragment F1.2, factor VIIa, von Willebrand factor, or C-reactive protein. Fibrinogen levels were significantly increased at 6 months compared to baseline, though still below the upper normal limit. In the perfusion chamber substudy, there was a decrease in thrombus area in non-CAD patients treated with pravastatin at both 3 and 6 months compared to baseline (by 21% and 34%, respectively). The CAD patients showed decreases in thrombus formation by 13% at 3 months, and by 16% at 6 months. The change in LDL-C- correlated modestly with the change in thrombus formation (r = 0.49; p < 0.01). CONCLUSIONS: Pravastatin therapy significantly decreased thrombus formation and improved the fibrinolytic profile in patients with and without CAD. These early effects may, in part, explain the benefit rendered in primary and secondary prevention of CAD.  (+info)

Adhesive interaction between P-selectin and sialyl Lewis(x) plays an important role in recurrent coronary arterial thrombosis in dogs. (8/1009)

Cell adhesion molecules may play an important role in the disease process of acute coronary syndromes. We have shown a neutralizing anti-P-selectin monoclonal antibody and a sialyl Lewis(x)-containing oligosaccharide (SLe(x)-OS), an analogue of selectin ligand on leukocytes, reduce cyclic flow variations (CFVs) in a canine model of recurrent coronary arterial thrombosis, suggesting the important interaction between P-selectin and SLex for the pathophysiology of these syndromes. However, the functional role of these adhesion molecules in the thrombotic process remains unclear. Therefore, we investigated effects of SLe(x)-OS on CFVs, platelet P-selectin expression, and morphology of the stenotic site in the same model. Anesthetized open-chest dogs (n=34) were randomly divided into 4 groups after developing CFVs. Dogs intravenously received saline or graded doses of SLe(x)-OS (5, 20, or 40 mg/kg bolus) infusion followed by a continuous infusion (5 mg. kg-1. h-1) for 60 minutes. By flow cytometric analysis, P-selectin expression on platelets after CFVs was significantly upregulated during CFVs. Immunohistochemical analysis revealed the incorporation of platelets with upregulated P-selectin within thrombi at the stenotic site. Microscopic observations revealed the presence of numerous platelets adhered to leukocytes at the stenotic site on the damaged endothelium. SLe(x)-OS significantly reduced CFVs, inhibited the P-selectin expression on platelets, and prevented the adherence of platelets and leukocytes. These findings further support the notion that the adhesive interaction between P-selectin on platelets and SLe(x) on leukocytes plays an important role in platelet-mediated thrombus formation in this model.  (+info)

TY - JOUR. T1 - Molecular imaging identifies regions with microthromboemboli during primary angioplasty in acute coronary thrombosis. AU - Sakuma, Tadamichi. AU - Sklenar, Jiri. AU - Leong-Poi, Howard. AU - Goodman, Norman C.. AU - Glover, David K.. AU - Kaul, Sanjiv. PY - 2004/7/1. Y1 - 2004/7/1. N2 - Microthromboemboli (MTE) may contribute to the no-reflow phenomenon in acute myocardial infarction (AMI) either spontaneously or after primary percutaneous transluminal coronary angioplasty (PTCA). We hypothesized that myocardial MTE in acute coronary syndromes can be identified on imaging by in vivo 99mTc labeling of the coronary thrombus with a compound that binds to the glycoprotein IIb/IIIa present on activated platelets (DMP-444). Methods: Fifteen dogs underwent left anterior descending coronary artery (LAD) injury in to produce thrombus, whereas 5 control dogs had LAD ligation. Before recanalization, the risk area (RA) and myocardial blood flow (MBF) were measured, and in vivo thrombus ...
Plaque erosion is suspected in the presence of an acute luminal thrombus that is in direct contact with the underlying intima comprising smooth muscle cells and proteoglycan with an absence of endothelial lining (1). The erosive plaques are rich in versican, hyaluronan, and type III collagen, unlike rupture or stable plaques, which are rich in type I collagen (2). The erosion lesions are more often eccentric and infrequently calcified; they show minimal inflammation with a few or absent macrophages and T-lymphocytes (2). The media underneath plaque erosions are similar to plaques with mild stenosis, rich in smooth muscle cell actin, which is also highly expressed in intimal smooth muscle cells in erosions. Plaque erosions often show negative remodeling. It is likely that spasm may play an important role in plaque erosion.. Plaque erosion accounts for 25% to 35% of coronary thrombi in patients dying of acute myocardial infarction and/or sudden coronary death (1). Plaque erosions occur in ...
The Academic Research Consortium (ARC) divides stent thrombosis (ST) into early (within 30 days), late (30 days to 1 year), and very late (beyond 1 year). Intravascular imaging studies, to date mostly using intravascular ultrasound (IVUS), have provided clues with regard to the causes of ST-primarily by focusing on either early or very late ST, although each study usually includes a small number of patients with events between 30 days and 1 year. In this issue of JACC: Cardiovascular Interventions, the current study is similar in that 15 of 18 patients have very late ST with only 3 patients presenting earlier than 1 year (and those 3 at least 172 days) after implantation (1).. The distinction between patients with early versus very late ST is important, especially after drug-eluting stent (DES) implantation. Studies should not combine these 2 groups of patients, because their fundamental mechanisms seem to be different.. The IVUS-identified causes or predictors of early ST are mechanical and ...
The changes in the final ventricular complex, the T-wave, and in the S-T segment of the electrocardiogram in coronary thrombosis have been extensively studied, both experimentally and clinically, since the early works of Herrick,1 Smith,2 and Pardee.3 As a result, it has been generally accepted that characteristic changes do occur in the majority of the cases, following an attack of coronary thrombosis.. In contrast, the changes in the initial ventricular complex have, up to recent years, received much less attention. Smith2 and Wearn4 observed that in coronary thrombosis the initial ventricular complex may not rarely be of a very small ...
Title: Small Peptide Radiopharmaceuticals in the Imaging of Acute Thrombus. VOLUME: 8 ISSUE: 20. Author(s):Jay E. Blum and Hirsch Handmaker. Affiliation:Section of Pulmonary Diseases, CIGNA Medical Group, 755 East McDowell Road, Phoenix,Arizona 85006, USA. Keywords:radiopharmaceuticals, acute thrombus, contrast venography, clotting process, vascular magnetic resonance scanning, receptor-receptor binding. Abstract: Until recently, imaging acute thrombus, especially the very prevalent condition of acute deep vein thrombosis relied on conventional imaging techniques utilizing either ultrasonography or contrast venography. The former procedure is limited by accuracy and the latter by technical considerations. Newer modalities such as magnetic resonance and computed tomographic scanning are yet to be validated in a prospective manner. Recent advances in the understanding of the pathogenesis of acute clot at the molecular level have suggested new avenues for detection of the acute thrombotic process ...
To the Editor:. There are questions regarding long-term safety of drug-eluting stents (DES), especially concern about an increased rate of late DES thrombosis compared with bare-metal stents. Numerous intravascular ultrasound (IVUS) studies have reported an increased frequency of late stent malapposition (LSM) in patients with DES (1-3), speculating that there may be a relationship between LSM and late stent thrombosis. The present study reports the long-term (,2 years) follow-up after the diagnosis of LSM was made using serial IVUS examination after DES implantation.. We previously reported 82 patients (85 lesions) with LSM from an overall cohort of 557 patients (705 native lesions) who underwent DES implantation (mean interval between baseline and follow-up IVUS of 6.1 ± 2.1 months). No intervention was performed in 542 patients (683 lesions) at 6-month follow-up (3). At least 2-year follow-up was available for all but 10 patients (12 lesions). Therefore, the present study reports 532 ...
Coronary thrombosis definition, a coronary occlusion in which there is blockage of a coronary arterial branch by a blood clot within the vessel, usually at a site narrowed by arteriosclerosis. See more.
Medical literature has recently focused on very late stent thrombosis (VLST) after drug-eluting stent implantation, while its mechanistic issue was not fully explored in the bare-metal stent (BMS) era. The first case is a 59-year-old man presenting with inferior non-ST-segment elevation myocardial infarction, 4 years after BMS implantation (NIR 3.5/18 mm, Boston Scientific, Galway, Ireland) for a chronic total occlusion lesion in the proximal right coronary artery. Coronary angiograms showed Thrombolysis In Myocardial Infarction (TIMI) flow grade 1 and filling defects in the BMS deployed previously, and massive red thrombi attaching to uncovered stent struts were found by angioscope (Fig. 1,Online Video 1). Thrombectomy and adjunctive balloon angioplasty were performed based on the angioscopic findings, and TIMI flow grade 3 was obtained. The second case is a 71-year-old man who was admitted for a diagnosis of inferior non-ST-segment elevation myocardial infarction 10 years after a treatment ...
The present study showed that the thrombi of ruptured plaques were more significantly rich in fibrin and that more tissue factor and CRP were expressed in ruptured than in eroded plaques.. Acute coronary thrombosis leading to acute myocardial infarction may arise from a difference in underlying plaque morphology, namely rupture and superficial erosion.2-6 In acute coronary death with coronary thrombosis, two necropsy studies have found plaque rupture in 75% of cases and that erosion accounted for the remainder.2,6 Kojima and colleagues5 found plaque rupture in 81% and erosion in 19% of Japanese patients who died of acute myocardial infarction.5 The findings of the present study agree with these previous results. In contrast, Farb and colleagues3 and Burke and associates4 have reported that 56% of such deaths are associated with plaque rupture and 44% with erosion. In addition, they found plaque erosion in 69% of women who died of sudden ischaemic heart disease.3,4 These reports emphasised a high ...
A number of risk factors for stent thrombosis have been identified by previous investigators. Persistent dissection, longer stent length, and final lumen diameter within the stent were identified as independent multivariable predictors of stent thrombosis in a meta-analysis of 6,186 patients enrolled in six major clinical trials of coronary stenting (17). Other studies have identified balloon size ≤2.5 mm, bail-out situations, unstable angina or acute MI (15), ejection fraction, use of a combination of different stents, postprocedural dissections, and slow flow (16)as predictive of stent thrombosis.. Multivariate analysis of correlates of stent thrombosis is difficult to perform in even a study as large as this because of the low incidence of the primary end point. A common method of avoiding over-fitting is bootstrap model selection. It involves creating random data sets from the patient population, selecting correlates with stepwise model selection for each bootstrap sample, and counting the ...
the 1950s and 1960s debate raged as to whether coronary thrombosis was the cause or the consequence of ST-segment elevation myocardial infarction (STEMI). of lidocaine was common in the United States and in some European countries but was used sparingly in the United Kingdom and elsewhere. Exercise stress testing was rarely done soon after STEMI because of Ondansetron HCl safety concerns. Early coronary arteriography (in the first few days after STEMI) was rare even in the late 1980s. Since then we have seen marked changes in the management of patients with STEMI.1 2 3 4 In 1980 DeWood and colleagues5 reported that about 80% of patients with acute MI had coronary occlusion measured using coronary arteriography and that the occlusion was due to an intraluminal thrombus. Later studies showed that the coronary thrombus could be dissolved with intracoronary (and later intravenous) administration of streptokinase and a meta-analysis demonstrated a reduction in mortality. Experts remained skeptical ...
Background Clinical evidence suggests that intracoronary thrombus formation is associated with a high incidence of late restenosis after successful coronary intervention in patients with myocardial infarction. However, little is known about the mechanism by which intracoronary thrombi play pathological roles.. Methods and Results We analyzed the cellular constituents of 108 thrombi aspirated from coronary lesions with a thrombectomy device in 62 patients who underwent emergent coronary intervention for the treatment of acute (,24 hours) or recent (24∼72 hours) ST-segment-elevation myocardial infarction (44 male, 18 female, age 68.0±19.3 years). Immunohistological analysis of aspirated thrombotic materials revealed that the content of platelets, as determined by immunostaining for CD42a, had a negative correlation with the time after the onset of chest pain (correlation coefficient: −0.683, p,0.01). Immunofluorescent staining for CD34 and breast cancer resistant protein-1 (bcrp-1) detected ...
Percutaneous coronary intervention (PCI) and coronary stent insertion has become commonplace and is ubiquitous in the treatment of myocardial infarction. Use of dual antiplatelet therapy or DAPT (ASA plus clopidogrel, ASA plus prasugrel, ASA plus ticagrelor) is critical post PCI and coronary stent insertion to prevent stent thrombosis. The incidence of early stent thrombosis ranges around 1-2% while on DAPT while late stent thrombosis ranges from 0.2-0.6%.1 While the incidence may be low, acute stent thrombosis often presents as a STEMI and is associated with mortality rates of 20-45%. While several factors influences the rates of stent thrombosis, the most common cause of acute stent thrombosis is nonadherence to DAPT.2. ...
Another name for Coronary Thrombosis is Heart Attack. The treatment of a heart attack focuses on reducing pain, improving blood flow to the heart muscle ...
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Coronary thrombi in patients who die suddenly are more likely to display signs of healing if they are caused by a plaque erosion rather than a rupture, researchers found.
The pathophysiological model for the occurrence of STEMI describes sudden vessel closure, mostly due to plaque rupture or erosion and subsequent intracoronary occlusive thrombosis at the onset of symptoms.3 Plaque disruption results in exposure of the lipid-rich core of the plaque to the bloodstream, which causes activation and aggregation of platelets. As a result, a luminal thrombus occurs, which prevents normal blood supply to the myocardium. This explains why in many patients with acute transmural myocardial infarction, a platelet-rich, fresh thrombus can be found.12-15 The aspiration of thrombi in 95% of patients in general and fresh thrombi in particular in patients with STEMI in the present study confirms these perspectives and other studies with regard to the pathogenesis of this event. The fact that fresh thrombus could not be identified in all patients may be explained in part by disintegration of the very fragile fresh material by passage through the catheter or in the collection ...
DOWNLOAD : TELECHARGER PDF (anglais). Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism Of Stent Thrombosis (MOST) study ...
Coronary thrombus in patients undergoing primary PCI for STEMI: Prognostic significance and management.: Acute ST-elevation myocardial infarction (STEMI) usuall
Glycoprotein IIbCIIIa (GPIIbCIIIa) antagonists have the capability to destabilize coronary thrombi and restore vessel patency. Turbidometric light transmitting aggregometry 120511-73-1 supplier (LTA) was performed on the dual-channel lumiaggregometer (Payton Scientific, Buffalo, NY) to quantify Rabbit Polyclonal to IKK-gamma (phospho-Ser85) the level of collagen-induced platelet aggregation or disaggregation ahead of and 120511-73-1 supplier following contact with GPIIbCIIIa antagonists or particular vehicle handles. A 500?L aliquot of autologous PPP was utilized to empty each aggregometer. Test examples of PRP had been aliquoted at 450?L in aggregometer cuvettes. Aggregation was induced by addition of 50?L of 20?g/mL type We collagen (Chrono-Log, Havertown, PA), for your final focus of 2?g/mL. Aggregation was permitted to move forward for 3.5?min following agonist addition, a spot which typically represented the utmost level of aggregation. A book technique was utilized so that high ...
Coronary thrombosis is now widely recognised as a major cause of sudden cardiac death, acute myocardial infarction, and unstable angina pectoris. Inflammation is an important component of the atherosclerotic lesion. In this review we will discuss inflammatory mechanisms in relation to atherosclerosis and clinical coronary thrombosis.. The response to injury hypothesis postulates that endothelial dysfunction represents the initial step of atherogenesis and can be induced by haemodynamic forces, by a variety of vasoactive substances, by mediators from blood cells, and directly from risk factors for atherosclerosis.1 Upon activation, endothelial cells express various cellular adhesion molecules, cytokines, chemokines, and growth factors. Focal arterial inflammatory activity is one of the most prominent characteristics of the atherosclerotic process.2,3 Inflammation is also implicated in the pathogenesis of acute syndromes, as suggested by histological findings in unstable coronary plaques,4-6 ...
The past few years have witnessed a remarkable advance in our understanding of the pathophysiology of coronary atherosclerosis.1-3 Others in this Supplement review the types of atherosclerotic lesions and the mechanisms of progression with plaque instability and disruption, and record how the lesions can be stabilised or even made to regress. Here we focus on the thrombotic phenomena that ...
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trigger the formation of a clot causing a coronary thrombosis. This stops the flow of blood through the vessel and the capillary network it supplies causing a heart attack. The portion of the heart muscle deprived of oxygen dies quickly of oxygen starvation. If the area is not too large, the undamaged part of the heart can, in time, compensate for the damage. Coronary bypass surgery uses segments of leg veins to bypass the clogged portions of the coronary arteries. ...
Project plan. Modeling rat bloodstream using fluorescence imaging data. Alander et al. (2012). The Research Project. Rats with artificial coronary thrombosis Chest blood vessel to heart muscle Replace bypass for people with bad coronary vessels ?. Team. Slideshow 6945525 by...
Stent thrombosis (ST) is an acute thrombotic occlusion in the stented segment of a coronary artery. It is a serious complication that frequently presents as an acute myocardial infarction and/or sudden death. The most recently accepted definition established by the Academic Research Consortium classifies ST as: early (occurring within 30 days), late (30 days to 1 year) or very late (after 1 year). Very late ST has been reported following drug-eluting stent implantation with rates up to 0.6% per year. However, very late ST is unusual after bare-metal stent (BMS) implantation. Here we report a case of patient presenting with ST-elevation myocardial infarction due to very late ST occurring 2 years after BMS implantation. Keywords: Stent thrombosis, Percutaneous coronary intervention, Bare metal stent, Drug eluting stent
Case Reports in Critical Care is a peer-reviewed, Open Access journal that publishes case reports in all areas of critical care medicine.
TY - JOUR. T1 - Drug-eluting stent thrombosis in patients undergoing non-cardiac surgery [3]. AU - Ramakrishna, H.. PY - 2008/7. Y1 - 2008/7. UR - http://www.scopus.com/inward/record.url?scp=45849112465&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=45849112465&partnerID=8YFLogxK. U2 - 10.1093/bja/aen159. DO - 10.1093/bja/aen159. M3 - Letter. C2 - 18556703. AN - SCOPUS:45849112465. VL - 101. JO - British Journal of Anaesthesia. JF - British Journal of Anaesthesia. SN - 0007-0912. IS - 1. ER - ...
For the past 15 years evidence has stacked up showing patients with acute coronary thrombosis improve their survival chances by 50-82
Pre-discharge transthoracic echocardiography revealed the left ventricle with normal dimensions and overall systolic function (left ventricular ejection fraction 56%), and hypokinesis of the basal inferior wall. The patient was discharged on the fifth day, medicated with aspirin 100 mg once daily, ticagrelor 90 mg twice daily, atorvastatin 40 mg once daily, ramipril 2.5 mg once daily, ivabradine 5 mg twice daily, colchicine 1 mg once daily and pantoprazole 20 mg once daily.. After discharge the patient was referred for a cardiology consultation in addition to previous medical consultations. Prednisone was introduced three months after the event by the rheumatology team. At the six-month cardiology consultation, the patient presented free of angina with good functional capacity, and no new cardiovascular events have been reported.. Discussion. Coronary artery disease is extremely uncommon in BD, with a reported prevalence of 0.5%.4 As in the case presented, most BD patients with coronary events ...
coronary (artery) occlusion. coronary (artery) rupture. cardiac infarction. infarction of heart, myocardium, or ventricle. rupture of heart, myocardium, or ventricle. acute myocardial infarction occurring within four weeks (28 days) of a previous acute myocardial infarction, regardless of site. subsequent type 1 myocardial infarction. reinfarction of myocardium. coronary (artery) embolism. coronary (artery) thrombosis. recurrent myocardial infarction. ...
Current trial protocol definitions of stent thrombosis. CEC process for adjudication of definite/confirmed ST has been the same for all major trials of DES Acute myocardial ischemia (ECG major ST abnormality or any biomarker elevation) ANDAngiographic or autopsy evidence of stent occlusion or thrombusAbsence of intervening TLRPossible/presumed STMI in target vessel territory without angiographic evidence of thrombus or other culpritVariably reported among different devices and within studi31646 Slideshow 1281571 by mardi
Almost all heart attacks occur when a blood clot suddenly and completely blocks a coronary artery. This condition is called a coronary thrombosis, or simply a coronary. The part of the heart muscle nourished by the blocked artery becomes damaged by lack of oxygen.
s body exhumed in order to prove her case. We were told that my sister had died of coronary artery thrombosis, but she didnt have a history of heart disease, she said this week. There was no trace of alcohol or barbiturates in her system, but there was this brown cereal-type substance which was never identified. I believe she was killed because someone wanted to silence her. But who? Maxine admits that she has privately confronted the man she suspects of being responsible for her sisters death. ...
Recruitment of leukocytes is a hallmark of stent thrombosis, according to results from the PRESTIGE study presented at ESC Congress1 and published in European
As per investigate information distributed by the American Journal of Clinical Nutrition, people that incorporate general day by day admission of Omega 3 can diminish the danger of heart assault (coronary thrombosis) by up to 70%. Such reassuring news has produced a decent arrangement of enthusiasm for Omega 3 recently. What is Omega 3? Omega 3 is, truth be told, a polyunsaturated unsaturated fat which, as it goes through the limentary channel (stomach related tract through the human body), separates existing cholesterol and stores a minutely thin obstruction to keep its transformation. Omega 3 attempts to battle again the main cholesterol offender that causes thickening of the blood. These coagulations at that point square veins causing heart assaults or, on the off chance that they achieve the mind, strokes. Omega 3 is most regularly connected with the oils found in angle. Best known sources are mackerel, trout and salmon in spite of the fact that the oils can be removed from white fish; and ...
Wells Carl CLINGMAN - Yavapai County Arizona - b. March 6, 1899, Ft. Worth, Tx. d. Jan. 27, 1955, Cottonwood, Az. COD: Coronary thrombosis h/o Hattie Louise Clingman s/o Charles Mmagne & Atlanta E. (Stevens) Clingman Occ: Farm laborer Wagoner, Med. Dept. - WW I Enlisted: June 4, 1917 Discharged: Aug. 21, 1919 Note: Resided in Az. 50 years. Site # A/166 Westcott Funeral Home, Cottonwood, Az. Burial: Jan. 20, 1955 Az. death records /Military records Picture taken by Kelley Townsend
Alma Mae ORTWINE - Yavapai County Arizona - Alta M.(Troutwine) Ortwine b. Feb. 2, 1900, Pidgion, Mich. d. July 9, 1964, Prescott, Az. COD: Coronary thrombosis w/o Frank Simon Ortwine d/o Adolph & Amelia M. (Wagoner) Troutman Site # S/010/H Hampton Funeral Home, Prescott, Az. Buried July 13, 1964
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We assessed risk factors for sudden coronary death among persons without a history of coronary heart disease (unexpected sudden coronary death) and persons with a history of coronary heart disease (sudden coronary heart disease death). We analyzed national data to calculate death rates and odds rati …
TY - JOUR. T1 - Urgent PCI in patients with stent thrombosis: an observational single-center study comparing thrombus aspiration and standard PCI. AU - Burzotta, Francesco. AU - Trani, Carlo. AU - Crea, Filippo. AU - De Vita, Maria. AU - Porto, Italo. AU - Leone, Antonio Maria. AU - Niccoli, Giampaolo. AU - Rebuzzi, Antonio Giuseppe. AU - Mazzari, Mario Attilio. AU - Schiavoni, Giovanni. AU - Romagnoli, Enrico. AU - Talarico, Giovanni Paolo. AU - Biondi-Zoccai, Giuseppe G L. AU - Mongiardo, Rocco. PY - 2008. Y1 - 2008. N2 - Objectives: Stent thrombosis (ST) is a recognized complication of percutaneous coronary interventions (PCI). Due to the high thrombus burden present in ST, the use of thrombus aspiration (TA) may enhance the angiographic results by limiting distal embolization. Methods: Consecutive patients undergoing urgent PCI due to ST were studied, consisting of two groups according to the type of intervention (standard PCI [SP] or TA). TIMI flow, corrected TIMI frame count (cTFC), ...
DESs have dramatically decreased the need for coronary artery bypass graft (CABG) surgery and repeated PCI. However, late stent thrombosis is a small but important risk with DESs because it is commonly associated with sudden death or acute MI. The clinical occurrence of stent thrombosis after stent implantation can be defined as acute (, 24 h), subacute (1 to 30 d), late (30 d to 1 y), or very late (, 1 y). The clinical diagnosis of stent thrombosis can be defined as definite if proven angiographically or pathologically, probable if an MI occurs in the distribution of the stented artery, or possible if death is unexplained (1). Risk for subacute stent thrombosis is about 1% for both DESs and BMSs, but risk for very late stent thrombosis continues for at least 4 years with DESs at a rate of 2 to 4 events/1000 patients per year (1−3). The presumed cause is delayed or incomplete endothelialization of the stent struts. The unanswered question is whether the decrease in risk for death and MI ...
TY - JOUR. T1 - Usefulness of abciximab for treatment of early coronary artery stent thrombosis. AU - Casserly, Ivan P.. AU - Hasdai, David. AU - Berger, Peter B.. AU - Holmes, David R.. AU - Schwartz, Robert S.. AU - Bell, Malcolm R.. PY - 1998/10/15. Y1 - 1998/10/15. N2 - The clinical and angiographic outcomes of 10 patients who received abciximab as part of their therapy for early stent thrombosis was compared with 25 patients (using historical controls) who received conventional therapy. Although the angiographic outcome and the incidence of myocardial infarction in both groups was similar, there were no deaths or referral for emergency coronary bypass surgery in the abciximab-treated group versus 3 deaths and 10 referrals for emergency bypass surgery in the conventionally treated group.. AB - The clinical and angiographic outcomes of 10 patients who received abciximab as part of their therapy for early stent thrombosis was compared with 25 patients (using historical controls) who received ...
Most physicians believe that acute coronary syndromes (ACS) are due to coronary artery thrombosis resulting from plaque rupture of a metabolically active inflamed lesion characterized by a thin fibrous cap (thin-cap fibroatheroma [TCFA]), overlying a large necrotic core containing rich concentrations of cholesterol, cholesterol esters, and senescent macrophages (1). Such lesions also demonstrate spotty calcification and neovascularization arising from the vasa vasorum with plaque hemorrhage. Indeed, the chemical structure and morphology of the TCFA is so distinctive that numerous invasive and noninvasive imaging modalities have been developed to search for the mischievous TCFA prior to its becoming unstable, to improve prognostic discrimination and perhaps guide systemic or focal therapies.. However, although pathologic studies have demonstrated that the majority of thrombotic lesions responsible for acute myocardial infarction (AMI) and sudden cardiac death have a ruptured fibrous cap (RFC) ...
Lines of Zahn are a characteristic of thrombi that appear particularly when formed in the heart or aorta. They have visible and microscopic alternating layers (laminations) of platelets mixed with fibrin, which appear lighter and darker layers of red blood cells. Their presence implies thrombosis at a site of rapid blood flow that happened before death. In veins or smaller arteries, where flow is not as constant, they are less apparent. They are named after German-Swiss pathologist Friedrich Wilhelm Zahn. Atherosclerosis. Lee R, Adlam D, Clelland CA, Channon KM (2012). Lines of Zahn in coronary artery thrombus. Eur Heart J. 33 (9): 1039. doi:10.1093/eurheartj/ehs028. PMID 22345124. Stegman, JK, ed. (2006), Stedmans Medical Dictionary (28th ed.), Baltimore, MD: Lippincott, Williams, & Wilkins Kumar, V. et al. (2005). Hemodynamic Disorders, Thromboembolic Disease, and Shock. Robbins and Cotran Pathologic Basis of Disease. 7th edition. Elsevier Saunders: Pennsylvania. Simon S. Cross (ed.). ...
Novel nanostructured biomaterials: implications for coronary stent thrombosis Varvara Karagkiozaki,1,2 Panagiotis G Karagiannidis,1 Nikolaos Kalfagiannis,1 Paraskevi Kavatzikidou,1 Panagiotis Patsalas,3 Despoina Georgiou,1 Stergios Logothetidis11Lab for Thin Films – Nanosystems and Nanometrology (LTFN), Physics Department, Aristotle University of Thessaloniki, Thessaloniki, 2AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, 3Department of Materials Science and Engineering, University of Ioannina, Ioannina, Epirus, GreeceBackground: Nanomedicine has the potential to revolutionize medicine and help clinicians to treat cardiovascular disease through the improvement of stents. Advanced nanomaterials and tools for monitoring cell–material interactions will aid in inhibiting stent thrombosis. Although titanium boron nitride (TiBN), titanium diboride, and carbon nanotube (CNT) thin films are emerging materials in the biomaterial field, the effect of their surface properties on
To explore effective and convenient rescue therapy options for coronary artery aneurysms (CAA) with thrombosis in Kawasaki disease (KD). A total of
Thienopyridine antiplatelet drugs have been used for 15 years for the prevention of coronary stent thrombosis in patients undergoing percutaneous coronary intervention with stent placement. Ticlopidine, the first approved thienopyridine, has in large part been replaced by clopidogrel, a more potent …
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This study reports a significantly lower risk of ST during the first year after PCI with both n-DES and o-DES compared with BMS, but a higher risk of very late ST up to 3 years in the o-DES group compared with the BMS group; and a similar risk of very late ST in the n-DES and BMS groups. Although BMS have been proven to be safe in STEMI patients and the improvements of the new stent platforms have reduced restenosis rates, DES are superior in terms of a decrease in restenosis occurrence. This study suggests that n-DES are associated with a low risk of ST even on long-term follow-up and may be the preferred stent type in STEMI patients compared to BMS and o-DES. ...
The study by den Heijer and colleagues is of interest to both interventional cardiologists and internists. The availability of low-profile, flexible, and steerable angioscopic systems has allowed the routine percutaneous application of this technology. Interpretable images can now be obtained in most patients having interventional procedures, although the technique still has important limitations. Problems remain with aiming the angioscope, and a clear imaging field cannot always be obtained. The widespread availability of second-generation interventional technologies, including stents, atherectomy catheters, and local drug delivery systems, give the interventionist a choice of therapies. Precise knowledge of coronary morphology may have an important effect on the decision of which technique to use to treat a given lesion. The study by den Heijer and colleagues suggests that, in a few patients, the angioscopic information was useful to the clinician. These results, however, cannot be ...
Myocardial infarction. Theres a mouthful. Its a tongue-twiser, isnt it? And it sounds serious.. Well, it is.. Myocardial infarction is medical language for a heart attack. It means the death of tissue (an infarct) in the muscular wall of the heart (the myocardium).. Heart attack is known by several names. coronary thrombosis is a heart attack caused by a clot in the coronary arteries. Sometimes, it is caused by snoring. Coronary occlusion is a blocked artery that could have a number of causes. Myocardial infarction refers to the end result-the damage or death of a part of the heart muscle.. The heart never stops working. In contrast to the muscles in our arms and legs, the heart muscle never rests, although it does slow down when we sleep.. to do its important job of keeping us alive, the heart must have a regular and adequate supply of oxygen and nutrients for energy. For this reason, the heart receives its own supply of oxygen-rich blood by way of the coronary arteries. The sole purpose of ...
Shah, N., Garg, J., Agarwal, V., Mehta, K., Jacobs, L., Patel, N., Freudenberger, R. Stent Thrombosis is Not Increased in Cardiac Arrest Patients Undergoing Therapeutic Hypothermia: An Analysis of 15,079 Procedures. Poster presented at: American College of Cardiology, San Diego, CA.. ...
Review of the recent literature reveals little dealing with the effects of large doses of quinidine on ventricular tachycardia. No series comparable in size to this one has been noted within the past 15 years. McMillan1 recently reported two cases following coronary thrombosis treated successfully with quinidine. Reich2 reported a cure with a total of 185 grains given in a period of two and a half days, a dosage believed by him and also by Levine3 and Gold4 to be the largest dose given in a period of 60 hours. Some of the cases in this series had quinidine in ...
Feng QZ, Wang SW, Zhao YS, Zheng XQ.Subacute stent thrombosis happening at discharge. International Journal of Cardiology 119: E59-E62, No. 2, 10 Jun 2007 - ChinaGoogle Scholar ...
Thrombosis yw tolchenni gwaed a all fod yn farwol syn ffurfio yn y rhedweli (thrombosis rhedwelïol) neu yn y wythïen (thrombosis gwythiennol). Ar ôl i dolchen ffurfio, gall arafu neu rwystro llif gwaed a hyd yn oed gwahanu ei hun a theithio i organ. Gelwir tolchen syn teithio ir system gylchrediad yn emboledd.. Gan amlaf, mae modd atal thrombosis ac maen batholeg o drawiadau ar y galon, strociau thrombo-embolig a thrombo-emboledd gwythiennol (VTE) - sef y tri phrif achos o farwolaethau cardiofasgwlaidd.. Maer Bartneriaeth Effeithiau Gofal Iechyd Cyngor Ymchwil Peirianneg ar Gwyddorau Ffisegol ar Ddiagnosteg a Rheoli Tolchennu Gwaed a arweinir gan Brifysgol Abertawe yn cynnwys athrawon, darlithwyr, ymchwilwyr ôl-ddoethurol, a myfyrwyr o Goleg Peirianneg ac Ysgol Feddygaeth y Brifysgol yn ogystal â phartneriaid ym maes diwydiant a phartneriaid o dramor. Bydd y Bartneriaeth yn cynnal digwyddiad codi arian a chodi ymwybyddiaeth ar Gampws y Bae y Brifysgol ddydd Iau 13 Hydref lle y byddant ...
Thrombosis: Thrombosis,, formation of a blood clot in the heart or in a blood vessel. Factors that play a role in the formation of clots (thrombi) include injury to a blood vessel and
Although almost 10% of middle-aged persons who have major operations afterward develop thrombosis* a serious disease caused by clots which jam the blood vessels they dont need to....
We provide a state-of-the-art intracoronary imaging system that helps you optimize the treatment of patients and master complex lesions. Our optics-based imagin
Fuster, V; Fallon, JT; Nemerson, Y (November 1996). "Coronary thrombosis". Lancet. 348 Suppl 1: s7-10. doi:10.1016/s0140-6736( ... Thrombosis in Cardiovascular Disorders [Hardcover] Valentin Fuster (Author), Marc Verstraete (Author) Update on Coronary Risk ... "The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes". New England Journal of Medicine. 326 (4): 242-50 ... "The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes". New England Journal of Medicine. 326 (5): 310-8 ...
... was the direct cause of coronary thrombosis; in fact the closest relationship between coronary deaths and any single dietary ... Yudkin, John (27 July 1957). "Diet and Coronary Thrombosis". The Lancet. 270 (6987): 155-162. doi:10.1016/s0140-6736(57)90614-1 ... the alarming increase in many countries during the first half of the twentieth century in the incidence of coronary thrombosis ... was to summarise the evidence that the consumption of sugar was leading to a greatly increased incidence of coronary thrombosis ...
... and Thrombosis (Coronary or Pulmonary). Exercise caution before using epinephrine in arrests associated with cocaine or other ... Cardiac Arrest Algorithm Acute Coronary Syndromes Algorithm Pulseless Electrical Activity (PEA) / Asystole Algorithm ...
He has suffered a coronary thrombosis. After a short time of rest, he returns to preaching, and accepts an appointment as ...
Cause of death was coronary thrombosis. His remains were sent to Ottawa for burial. He was interred in the Jewish Cemetery on ...
He proposed that thrombosis in the coronary artery leads to the symptoms and abnormalities of heart attacks and that this was ... Siegel R (May 1958). "The man who discovered coronary thrombosis; James Brain Herrick, 1861-1954". The Journal of the Medical ... Herrick JB (1918). "Concerning thrombosis of the coronary arteries". Transactions of the Association of American Physicians. 33 ... Herrick JB (October 1983). "Landmark article (JAMA 1912). Clinical features of sudden obstruction of the coronary arteries. By ...
McIntire died in 1963 of coronary thrombosis. West Virginia Mountaineers football coaching records [1] NCAA Official Guide. ...
He died of coronary thrombosis in 1949. Frost, Terry (1988). Bradford City A Complete Record 1903-1988. Breedon Books Sport. ...
The cause of death was Coronary thrombosis. Narragansett Park's Old Colony Stakes was renamed the James H. Connors Memorial ...
Brown died of a coronary thrombosis in 1959. Brown was admitted to the Illinois bar in 1908. He joined the legal department of ...
Smith died of coronary thrombosis in September 1940. He was buried in the Jewish section of Fawkner Cemetery with full military ...
His sudden death was caused by coronary thrombosis. As a resident at Johns Hopkins Hospital in Baltimore, Bloodgood was aware ...
He had a previous condition of coronary thrombosis. Even if suicide had been suspected, the LA County Coroner's Office would ... his death certificate actually states arteriosclerosis general and coronary sclerosis as the cause of death. ...
He was born and educated in Berlin, Germany; he died in Northampton, Massachusetts from coronary thrombosis. He was influenced ... Koffka was forced to alter his lifestyle after developing a heart condition called Coronary thrombosis. However, his condition ...
He died on February 13, 1937 from coronary thrombosis. William Suddards Franklin Nelle Franklin Joseph Franklin Thomas Z. ...
Fujitani died of coronary thrombosis on February 11, 1965. Notable women of Hawaii. Peterson, Barbara Bennett, 1942-. Honolulu ...
The officially reported cause of death was coronary thrombosis. The National Economic Association (NEA) awards the "Samuel Z. ...
In February 1955, he became ill with coronary thrombosis. His health worsened in October, and he died on October 12, 1955, at ...
Richards died in Salt Lake City of coronary thrombosis. He was buried at Salt Lake City Cemetery. After Richards's death, ...
On April 28, 1948 in Dayton, Ohio, Moseley became ill; later dying on June 6, 1948 to Coronary thrombosis. His will dedicated ...
September 24, 1955: President Eisenhower suffered a coronary thrombosis. November 5, 1955: Racial segregation was forbidden on ...
Died, from coronary thrombosis, in Kansas City, Jackson County, Mo. on January 21, 1939. Interment at Forest Hill Cemetery, ...
He suffered from Bright's disease and died of coronary thrombosis. He told a reporter for the Carlsbad Current-Argus, two days ...
She died June 22, 1936 in Philadelphia of coronary thrombosis. Her correspondence is held in a collection by the Historical ...
He died from a coronary thrombosis near St Bartholomew's Hospital. List of Vice-Chancellors of the University of London The R. ...
Levine was a pioneer in the treatment of coronary thrombosis. He was the second American physician to diagnose the condition, ...
Miller died in Memphis, Tennessee in 1945 of coronary thrombosis. List of Major League Baseball career stolen bases leaders " ...
She died in 1968 in Crowborough of a coronary thrombosis. She saw service as a nurse during both World Wars. The 22-year-old ...
He died at home, in 1946, of a coronary thrombosis. "Funny Bones" (rag, 1909) "Dissatisfied" (1910) "Poison Rag" (1910) "Medic ...
... (July 1947). "Electrocardiographic Diagnosis and Prognosis of Recent Coronary Thrombosis or Occlusion". ... "Electrocardiographic Diagnosis and Prognosis of Recent Coronary Thrombosis or Occlusion", Journal of the Indiana State Medical ... Harvey N. Middleton (February 1943). "The Electrocardiographic Diagnosis and Treatment in Recent Coronary Occlusion". Journal ... "The Electrocardiographic Diagnosis and Treatment in Recent Coronary Occlusion", Journal of the Indiana State Medical ...
Marked Acceleration of Atherosclerosis After Lactobacillus casei-Induced Coronary Arteritis in a Mouse Model of Kawasaki ... Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32: e60-e71. *"Reumatoloogia", Reinhold Birkenfeldt, Tiit ...
Russert died on June 13, 2008, of a sudden coronary thrombosis (caused by a cholesterol plaque rupture).[17] Former NBC Nightly ...
Angiography is used to find aneurysms, leaks, blockages (thromboses), new vessel growth, and placement of catheters and stents ...
Obesity and thrombosis. Eur J Vasc Endovasc Surg. 2007-02, 33 (2): 223-33. PMID 17185009. doi:10.1016/j.ejvs.2006.10.006.. ... The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ... Dentali F, Squizzato A, Ageno W. The metabolic syndrome as a risk factor for venous and arterial thrombosis. Semin. Thromb. ... and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants.. ...
Venous thrombosis /. Thrombophlebitis. *primarily lower limb *Deep vein thrombosis. *abdomen *Hepatic veno-occlusive disease ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
Paris Thrombosis case-control Study". Arteriosclerosis, Thrombosis, and Vascular Biology. 20 (3): 892-8. doi:10.1161/01.ATV. ... Natural history of coronary disease with and without aortocoronary by-pass operation. Survival curves of 272 patients over a ...
Goodnight, Jr., Scott H.; Hathaway, William E. (2001). Disorders of Hemostasis and Thrombosis (2nd ed.). New York: McGraw-Hill ... They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ... It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC and efficacy of treatment in acute myocardial ...
... thrombosis. These changes create an exaggerated layered appearance (onion skinning).[11] ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ...
Coronary artery angioscopy, which first was used to reveal the presence of a blood clot in the coronary arteries of patients ... a b MDGuidelines , Arterial Embolism And Thrombosis From The Medical Disability Advisor by Presley Reed, MD. Retrieved on April ... Forrester JS, Litvack F, Grundfest W, Hickey A (1987). "A perspective of coronary disease seen through the arteries of living ...
Darvall KA, Sam RC, Silverman SH, Bradbury AW, Adam DJ (februar 2007). "Obesity and thrombosis". Eur J Vasc Endovasc Surg. Vol ... julij 2006). "The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk ... Dentali F; Squizzato A; Ageno W (julij 2009). "The metabolic syndrome as a risk factor for venous and arterial thrombosis". ... 2006). "Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic ...
Coronary perfusion pressures are decreased by these factors, which also increase myocardial oxygen consumption, possibly ... Venous thrombosis /. Thrombophlebitis. *primarily lower limb *Deep vein thrombosis. *abdomen *Hepatic veno-occlusive disease ... Excessive reduction in blood pressure can precipitate coronary, cerebral, or renal ischemia and, possibly, infarction. ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ...
Evidence suggests that vegetarians generally have lower rates of coronary heart disease, obesity, hypertension, type 2 diabetes ... Thrombosis Research. 100 (3): 153-60. doi:10.1016/S0049-3848(00)00313-3. PMID 11108902.. ...
Spontaneous coronary artery dissection (SCAD). *කිරීටක ශ්‍යානිය (Coronary thrombosis). *Coronary vasospasm. *Myocardial bridge ...
Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD). *Coronary thrombosis. *Coronary vasospasm ... "Thrombosis. 2013: 640723. doi:10.1155/2013/640723. PMC 3885278. PMID 24455237.. *^ Sanders, Gillian D.; Lowenstern, Angela; ... In men, coronary disease is more frequent, while in women, high systolic blood pressure and valvular heart disease are more ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (3): 490-, 497. doi:10.1161/01.ATV.0000118278.21719.17. PMID 14739125. ... Phase III Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease ...
"Thrombosis and Haemostasis. 101 (2): 271-78. doi:10.1160/th08-09-0575. PMID 19190809. Retrieved 19 June 2009.. ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 19 (2): 187-195. doi:10.1161/01.atv.19.2.187. PMID 9974397.. ... "Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta- ... These findings provide evidence that consuming polyunsaturated fats (PUFA) in place of SFA reduces Coronary Heart Disease (CHD ... Skeaff CM, Miller J (2009). "Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised ...
It is the second-leading cause of death in non-coronary intensive care unit (ICU) and the tenth-most-common cause of death ... People with sepsis need preventive measures for deep vein thrombosis, stress ulcers, and pressure ulcers unless other ... Medication to prevent deep vein thrombosis and gastric ulcers also may be used.[10] ...
From various lines of evidence, it appears that thrombosis and embolism is the predominant problem.[1] ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... irregularities in the vessel wall and turbulence increase the risk of thrombosis (the formation of blood clots) and embolism ( ...
After percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent, a U.S. Agency for ... Thrombosis Research. 110 (5-6): 255-8. doi:10.1016/S0049-3848(03)00379-7. PMID 14592543. Archived (PDF) from the original on 28 ... Gaciong Z (June 2003). "The real dimension of analgesic activity of aspirin". Thrombosis Research. 110 (5-6): 361-4. doi: ... Hall SL, Lorenc T (February 2010). "Secondary prevention of coronary artery disease". American Family Physician. 81 (3): 289-96 ...
Impaired endothelial function, causing hypertension and thrombosis, is often seen in patients with coronary artery disease, ... "Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 1090-100. doi:10.1161/ATVBAHA.115.306964. PMC 4882253. PMID 27127201.. ... Blood clotting (thrombosis & fibrinolysis). The endothelium normally provides a non-thrombogenic surface because it contains, ...
Arteriosclerosis, Thrombosis, and Vascular Biology (página oficial). *ASAIO Journal (página oficial). *Asian Journal of Oral ... Coronary artery disease (página oficial). *Cortlandt Forum (Cortlandtforum.com). *Critical Care Medicine (página oficial) ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (8): 1908-1915. doi:10.1161/ATVBAHA.111.225268. PMC 3141106. Retrieved ... "Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion." British Journal of ...
In 1939, his father died at the age of 58 in a San Francisco hospital,[8] which LaLanne attributed to "coronary thrombosis and ...
Coronary heart disease events. ( non-fatal myocardial infarction. , death. ). 1.29 (1.02-1.63). 1.32 (1.02-1.72). 1.18 (0.70- ... In older patients, there was an apparent increased incidence of breast cancer, heart attacks, venous thrombosis, and stroke, ... George, James L.; Colman, Robert W.; Goldhaber, Samuel Z.; Victor J. Marder (2006). Hemostasis and thrombosis: basic principles ... Beyond this, HRT improves heart contraction, coronary blood flow, sugar metabolism, and decreases platelet aggregation and ...
Kearon, Clive; Julian, JA; Newman, TE; Ginsberg, JS (1998). "Noninvasive Diagnosis of Deep Venous Thrombosis". Annals of ... Intravascular ultrasound image of a coronary artery (left), with color-coding on the right, delineating the lumen (yellow), ... It used in ultrasonography of deep venous thrombosis, wherein absence of vein compressibility is a strong indicator of ... Overuse of ultrasonography is sometimes as routine as screening for deep vein thrombosis after orthopedic surgeries in patients ...
Obesity and thrombosis". Eur J Vasc Endovasc Surg. 33 (2): 223-33. doi:10.1016/j.ejvs.2006.10.006. PMID 17185009.. Mentenanță ... The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of ... The metabolic syndrome as a risk factor for venous and arterial thrombosis". Semin. Thromb. Hemost. 35 (5): 451-7. doi:10.1055/ ... Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review ...
Coronary artery disease[20]. *Deep vein thrombosis - can lead to pulmonary embolism[21] ... "Thrombosis and Haemostasis. 117 (2): 238-245. doi:10.1160/TH16-03-0224. ISSN 0340-6245. PMC 6260118. PMID 27853809.. ... "Journal of Thrombosis and Haemostasis. 16 (2): 209-219. doi:10.1111/jth.13912. PMID 29193737. S2CID 46865986.. ... "Research and Practice in Thrombosis and Haemostasis. 2 (4): 678-683. doi:10.1002/rth2.12145. PMC 6178656. PMID 30349886.. ...
Coronary stents are placed during a coronary angioplasty. The most common use for coronary stents is in the coronary arteries, ... Vascular stents made of metals can lead to thrombosis at the site of treatment or to inflammation scarring. Drug-eluting stents ... The first use of a coronary stent is typically attributed to Jacques Puel [fr] and Ulrich Sigwart when they implanted a stent ... There is a wide variety of stents used for different purposes, from expandable coronary, vascular and biliary stents, to simple ...
Coronary thrombosis refers to the formation and presence of thrombi in the coronary arteries of the heart. Note that the heart ... Coronary sinus thrombosis as a severe complication after procedures. The coronary sinus is the venous counterpart to the ... Inflammation may play a causal role in coronary artery disease and subsequent myocardial infarction due to coronary thrombosis ... Coronary thrombosis is defined as the formation of a blood clot inside a blood vessel of the heart. This blood clot may then ...
Stent thrombosis is a rare complication of percutaneous coronary intervention and carries a poor prognosis. Recent improvements ... Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry. J Am Coll Cardiol. 2009;53:1399-409.CrossRef ... Coronary stent thrombosis has been defined by the Academic Research Consortium criteria. Four types of thrombosis are defined ... Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the acute ...
This is a list of notable people who have died from coronary thrombosis, in chronological order. 1882: Charles Darwin (12 ...
Anticoagulants in Coronary Thrombosis. Br Med J 1947; 2 doi: https://doi.org/10.1136/bmj.2.4535.929-c (Published 06 December ...
Fibrinolytic Therapy of Coronary Thrombosis. Br Med J 1963; 1 doi: https://doi.org/10.1136/bmj.1.5335.915 (Published 06 April ...
... a coronary occlusion in which there is blockage of a coronary arterial branch by a blood clot within the vessel, usually at a ... coronary thrombosis in Medicine Expand. coronary thrombosis n. Obstruction of a coronary artery by a thrombus, often leading to ... coronary thrombosis. noun 1. a condition of interrupted blood flow to the heart due to a blood clot in a coronary artery, ... a coronary occlusion in which there is blockage of a coronary arterial branch by a blood clot within the vessel, usually at a ...
Subacute thrombosis in association with CYPHER coronary stents - What is known? [letter to US physicians]. 2003 July 7. ... Reason for posting: The use of coronary stents has improved the results of percutaneous coronary revascularization procedures. ... New advances in the management of acute coronary syndromes: 3. The role of catheter-based procedures. CMAJ 2002;166(1):51-61. ... Patients were eligible if they had disease of a native coronary artery (i.e., those with diseased grafts were excluded) in the ...
Investigational factor Xa inhibitors for thrombosis and acute coronary syndromes.. Romualdi E1, Ageno W. ...
... Bruno da Silva Matte, Gustavo Neves de Araujo, ... due to simultaneous acute coronary artery occlusions of two major coronary arteries in a patient with coronary ectasia. The ... Very late stent thrombosis could be the cause of the first occlusion, triggering the event in the other vessel. In addition, ... We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may ...
coronary thromboses synonyms, coronary thromboses pronunciation, coronary thromboses translation, English dictionary definition ... of coronary thromboses. n. Obstruction of a coronary artery by a thrombus, often leading to destruction of heart muscle. n a ... coronary thrombosis. (redirected from coronary thromboses). Also found in: Thesaurus, Medical, Encyclopedia. coronary ... cor′onary thrombo′sis. n. a coronary occlusion in which there is blockage of a coronary arterial branch by a blood clot in the ...
A 1976 autopsy preparation comprising sections of coronary arteries from six different individuals who died from ischaemic ... A 1976 autopsy preparation comprising sections of coronary arteries from six different individuals who died from ischaemic ... Cardiac Pathology: Coronary artery: Atheroma and thrombosis. Cardiac Pathology: Coronary artery: Atheroma and thrombosis. ...
Another name for Coronary Thrombosis is Heart Attack. The treatment of a heart attack focuses on reducing pain, improving blood ... PubMed Coronary Thrombosis References *Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD. Coronary calcification, coronary ... Coronary Thrombosis Surgery. Blocked coronary arteries require bypass surgery. The aim is to provide blood flow to the artery ... Coronary Thrombosis Thrombolytics. Coronary arteries can become narrowed when cholesterol builds up on the inside wall of the ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
... dynamic coronary thrombosis leading to infarction and/or sudden death: autopsy evidence of recurrent mural thrombosis with ... Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res. 2004; 61: 498-511. ... Plaque Instability Frequently Occurs Days or Weeks Before Occlusive Coronary Thrombosis. Saskia Z.H. Rittersma, Allard C. van ... Plaque Instability Frequently Occurs Days or Weeks Before Occlusive Coronary Thrombosis. Saskia Z.H. Rittersma, Allard C. van ...
... coronary bypass surgery, and coronary angioplasty); (3) angiographic data. Any stenosis in a main coronary artery was graded in ... From 1983 to 1992, 2141 of the 4754 patients admitted to our coronary division underwent coronary angiography as part of the ... Alcohol consumption and coronary atherosclerosis progression-the Stockholm female coronary risk angiographic study. ... This ATS score was calculated for each of the main coronary vessels as well as for the entire visible coronary tree. ...
... undergoing percutaneous coronary intervention (PCI) with stenting who do not continue oral anticoagulation are at increased ... In this patient population, therapy directed at reducing both thromboembolism (via oral anticoagulation) and stent thrombosis ( ... Currently available data suggest that patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI ...
Quick removal of coronary thrombosis allows for better visualization of underlying vessel morphology & can improve patient ... When coronary blood flow is constricted, literally every second and, every heartbeat matters. And with the right tools, youll ... Removing coronary thrombus quickly is critical to reducing the risk of1: ... In addition to improving patient outcomes, coronary thrombus removal makes it possible for you to2: ...
Stent thrombosis, myocardial infarction, and death after drug-eluting and bare-metal stent coronary interventions.. Jensen LO1 ... Use of DES might be associated with increased risk of stent thrombosis (ST), myocardial infarction (MI), and death. ... From January 2002 through June 2005, data from all percutaneous coronary interventions in western Denmark were prospectively ...
... that advocates the myocardial infarction as consequence of coronary thrombosis, was introduced by the American Dr. James Bryan ... Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of ... Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of ... of coronary thrombosis*;[26,27]. e. Hellstrom in 1970 demonstrated experimentally the coronary thrombosis secondary to acute ...
Abstract 16316: Angiographic Outcomes After Percutaneous Coronary Intervention for Definite Stent Thrombosis. Shunsuke Kubo, ... Background: Angiographic outcomes after percutaneous coronary intervention (PCI) for stent thrombosis (ST) have not been ... Abstract 16316: Angiographic Outcomes After Percutaneous Coronary Intervention for Definite Stent Thrombosis ... Abstract 16316: Angiographic Outcomes After Percutaneous Coronary Intervention for Definite Stent Thrombosis ...
Late stent thrombosis after the use of a bioresorbable vascular scaffold for the treatment of in-stent restenosis. Lee, Wei- ... Home , December 2016 - Volume 27 - Issue 8 , Late stent thrombosis after the use of a bioresorbable vascu... ... Late stent thrombosis after the use of a bioresorbable vascular scaffold for the treatment of in-stent restenosis ... Thought you might appreciate this item(s) I saw at Coronary Artery Disease.. ...
Thrombospondins and Premature Coronary Artery Disease. Time to Go Beyond Genotype-Phenotype Association Studies. Anders Hamsten ... Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:6-7, originally published January 1, 2003 ... Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:6-7, originally published January 1, 2003 ... Your Name) thought you would like to see the Arteriosclerosis, Thrombosis, and Vascular Biology web site. ...
To me the title of this very interesting book was puzzling, and I half expected to read a discussion of coronary insufficiency ... The Incubation Period of Coronary Thrombosis.. Ann Intern Med. 1964;60:169-170. doi: https://doi.org/10.7326/0003-4819-60-1-169 ... Perhaps a more accurate title would have been "Pathogenesis of Coronary Disease." Dr. Osborn is a pathologist who has examined ... carefully and thoughtfully many coronary arteries in humans who died of cardiac disease, as well as accidents or other ...
LARGE PERICARDIAL EFFUSION COMPLICATING ACUTE CORONARY THROMBOSIS1 E. STERLING NICHOL, M.D., F.A.C.P. ... The clinical features of the pericarditis found during the course of some cases of acute coronary artery thrombosis have been ... LARGE PERICARDIAL EFFUSION COMPLICATING ACUTE CORONARY THROMBOSIS1. Ann Intern Med. ;11:1900-1906. doi: 10.7326/0003-4819-11-10 ... White4 comments on the infrequency of pericardial effusion following coronary thrombosis and avers ...
Coronary artery disease (CAD) is the most common type of heart disease worldwide. It is the leading cause of death in the ... Risk Factors For Coronary Artery Disease. Diagnosing Coronary Artery Disease. Symptoms of Coronary Artery Disease. Prognosis. ... What Is Coronary Artery Disease. Coronary Artery Disease occurs when the coronary arteries, the blood vessels that bring blood ... What Causes Coronary Artery Disease. Coronary artery disease is caused by the hardening of the arteries, which is also known as ...
J. W. van Werkum, A. A. Heestermans, A. C. Zomer et al., "Predictors of coronary stent thrombosis. The dutch stent thrombosis ... DIC has been shown to be involved in the thrombosis of coronary vessels [12] and severe cardiac dysfunction as a result of the ... Acute coronary stent thrombosis remains a worrisome complication after PCI. There are many risk factors and causes associated ... O. Cakir, O. Ayyildiz, A. Oruc, and N. Eren, "A young adult with coronary artery and jugular vein thrombosis: a case report of ...
The National Center for Biomedical Ontology was founded as one of the National Centers for Biomedical Computing, supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028 ...
... within the coronary artery of the heart. Coronary thrombosis leads to a heart attack or myocardial infarction. ... Illustration of a coronary thrombosis: the form- ation of a thrombus (blood clot) ... Illustration of a coronary thrombosis: the form- ation of a thrombus (blood clot) within the coronary artery of the heart. ... Coronary thrombosis leads to a heart attack or myocardial infarction. In this artists impression of the branched interior of ...
CONCLUSIONS Plaque erosion is an important substrate for coronary thrombosis in patients dying of acute myocardial infarction. ... OBJECTIVE To evaluate the prevalence of plaque erosion as a substrate for coronary thrombosis. ... Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction ... Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction ...
Proximal coronary artery intervention: Stent thrombosis, restenosis and death. Calais, Fredrik Lagerqvist, Bo Uppsala ... Background: Percutaneous coronary intervention (PCI) of lesions in the proximal left anterior descending coronary artery (LAD) ... one-vessel coronary artery disease in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). We evaluated ... may confer a worse prognosis compared with the proximal right coronary artery (RCA) and left circumflex coronary artery (LCX). ...
  • A coronary thrombus is asymptomatic until it causes significant obstruction, leading to various forms of angina or eventually a myocardial infarction. (wikipedia.org)
  • Coronary thrombosis and myocardial infarction are sometimes used as synonyms, although this is technically inaccurate as the thrombosis refers to the blocking of blood vessels with a thrombus, while myocardial infarction refers to heart tissue death due to the consequent loss of blood flow to the heart. (wikipedia.org)
  • citation needed] Due to the large number of cases of myocardial infarction leading to death and disease in the world, there has been extensive study towards the generation of clots specifically in the coronary arteries. (wikipedia.org)
  • Inflammation may play a causal role in coronary artery disease and subsequent myocardial infarction due to coronary thrombosis. (wikipedia.org)
  • Coronary "microembolization" is being explored as a focal point for coronary thrombus formation and subsequent sudden death due to acute myocardial infarction. (wikipedia.org)
  • Management of symptomatic coronary thrombosis follows established treatment algorithms for myocardial infarction. (wikipedia.org)
  • It determined that preemptive treatment with percutaneous coronary intervention (PCI) did not lead to a difference in death or myocardial infarction over a 15-year period. (wikipedia.org)
  • We here report a case of ST-elevation myocardial infarction (STEMI) due to simultaneous acute coronary artery occlusions of two major coronary arteries in a patient with coronary ectasia. (hindawi.com)
  • Acute ST-elevation myocardial infarction (STEMI) typically is caused by occlusive coronary thrombus formation superimposed on a ruptured or eroded atherosclerotic plaque. (ahajournals.org)
  • Stent thrombosis, myocardial infarction, and death after drug-eluting and bare-metal stent coronary interventions. (nih.gov)
  • Use of DES might be associated with increased risk of stent thrombosis (ST), myocardial infarction (MI), and death. (nih.gov)
  • The thrombogenic theory, that advocates the myocardial infarction as consequence of coronary thrombosis, was introduced by the American Dr. James Bryan Herrick in 1912,[1] being entrenched worldwide in the medical culture in spite of important clinical, pathological and cardiac images studies showing discrepancies in their findings, basically conflicting with the conceived pathophysiology for this theory. (positivehealth.com)
  • Initial efforts to apply anticoagulant therapy early in the treatment of acute myocardial infarction and then long- term did not serve to further the cause of the coronary thrombosis hypothesis. (positivehealth.com)
  • On the other hand, in patients with myocardial infarction (MI), the current treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is the use of myocardial reperfusion either with thrombolytic therapy, primary percutaneous coronary intervention or coronary bypass surgery. (positivehealth.com)
  • To me the title of this very interesting book was puzzling, and I half expected to read a discussion of coronary insufficiency or impending myocardial infarction. (annals.org)
  • The Association of the CHA2DS2VASc Score with Acute Stent Thrombosis in Patients with an ST Elevation Myocardial Infarction Who Underwent a Primary Percutaneous Coronary Intervention. (annals.org)
  • We describe a case of the patient who developed DIC after suffering myocardial infarction and subsequently had recurrent coronary stent thrombosis. (hindawi.com)
  • Coronary thrombosis leads to a heart attack or myocardial infarction. (sciencephoto.com)
  • DESIGN Pathological study in patients with acute myocardial infarction not treated with thrombolysis or coronary interventional procedures. (bmj.com)
  • CONCLUSIONS Plaque erosion is an important substrate for coronary thrombosis in patients dying of acute myocardial infarction. (bmj.com)
  • 7,8 They investigated the rates of major adverse cardiac events (MACE-defined by a composite of death, myocardial infarction, stent thrombosis, and repeat revascularization) in patients undergoing NCS following either BMS 7 or DES 8 placement. (apsf.org)
  • Background Bivalirudin started during transport for primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction significantly reduced major bleeding compared with heparin with or without glycoprotein IIb/IIIa inhibitors (GPI), but it was associated with an increase in AST. (onlinejacc.org)
  • He further added, "They elucidate a novel mechanism that we believe can contribute to coronary thrombosis, a major cause of sudden cardiac death and acute myocardial infarction. (pharmiweb.com)
  • We proceeded directly to coronary angiography which showed an ectatic aneurysmal right coronary artery (RCA) with heavy thrombotic burden (figure 1) but trombolysis in myocardial infarction 3 flow. (bmj.com)
  • Acute ST-segment elevation myocardial infarction after amoxicillin induced anaphylactic shock in young adult with normal coronary arteries: a case report. (springer.com)
  • Moreover, typical KD symptoms and acute myocardial infarction were not found in CAA with thrombosis. (springermedizin.de)
  • Thrombotic occlusion of an epicardial coronary artery on the grounds of atherosclerotic plaque is considered the ultimate step in AMI (acute myocardial infarction). (clinsci.org)
  • We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial infarction). (clinsci.org)
  • The aim of this study was to investigate the protective effects of rLj-RGD3 against acute myocardial infarction (AMI) induced by coronary artery thrombosis, as well as the underlying mechanisms. (deepdyve.com)
  • The patient was transferred to the coronary intensive care unit with the diagnosis of non-ST elevation myocardial infarction. (who.int)
  • Since the patient was young, had no coronary risk factors and had an INR of 1.6, myocardial infarction was thought to be due to coronary embolism. (who.int)
  • In this paper, we report a rare case of myocardial infarction, which occurred as a result of a coronary embolism in a patient with prosthetic mitral valve thrombosis. (who.int)
  • Charles and colleagues reported that coronary embolism occurs in the left coronary artery in 75% of cases and three-quarters of them present with ST elevation myocardial infarction, whereas the rest present with non-ST elevation myocardial infarction [8]. (who.int)
  • In our case, the right coronary artery was involved and the patient presented with non-ST elevation myocardial infarction. (who.int)
  • The term coronary thrombosis and myocardial infarction, or heart attack, is often used interchangeably. (planetdrugsdirect.com)
  • Acute transmural myocardial infarction - coronary vasospasm, thrombosis or coronary embolus? (sun.ac.za)
  • Cardiac catheterization 2 months later demonstrated a significant area of myocardial damage as well as a large mural thrombus, but the coronary arteries appeared normal apart from a large irregular filling defect in the proximal left anterior descending (LAD) branch, apparently due to a thrombus. (sun.ac.za)
  • The authors of the meta-analysis said that the suggestion that this everolimus-eluting stent could actually best bare-metal stents for stent thrombosis first became plausible at last August's ESC, in results from the EXAMINATION study, which compared the two stent types in about 1,500 acute myocardial infarction patients. (wordpress.com)
  • Although the angiographic outcome and the incidence of myocardial infarction in both groups was similar, there were no deaths or referral for emergency coronary bypass surgery in the abciximab-treated group versus 3 deaths and 10 referrals for emergency bypass surgery in the conventionally treated group. (elsevier.com)
  • 3, and 44% presented with acute coronary syndrome or myocardial infarction. (elsevier.com)
  • Coronary Thrombosis and the Pathogenesis of Acute Myocardial Infarction. (bethanystruble.com)
  • In medical terminology, it is known as myocardial infarction or Coronary Thrombosis . (thrombosisdisease.com)
  • Despite remarkable progress in fighting against myocardial infarction, the thrombotic complications of the coronary artery are still a significant cause of morbidity and mortality worldwide. (benthambooks.com)
  • Microthromboemboli (MTE) may contribute to the no-reflow phenomenon in acute myocardial infarction (AMI) either spontaneously or after primary percutaneous transluminal coronary angioplasty (PTCA). (elsevier.com)
  • We hypothesized that myocardial MTE in acute coronary syndromes can be identified on imaging by in vivo 99m Tc labeling of the coronary thrombus with a compound that binds to the glycoprotein IIb/IIIa present on activated platelets (DMP-444). (elsevier.com)
  • Most patients with coronary artery disease receive aspirin for primary or secondary prevention of myocardial infarction, stroke, and death. (tomhsiung.com)
  • Over the last decade, Primary percutaneous coronary intervention (PCI) has been established as the optimal treatment of ST elevation myocardial infarction [1]. (credoweb.ro)
  • The smaller vessel diameter allows less blood to flow and facilitates progression to a myocardial velscomfeasavingwa.mondmilksevemengeotroxtunordovora.cog risk factors for coronary thrombosis are high LDL cholesterol, smoking, sedentary lifestyle, and velscomfeasavingwa.mondmilksevemengeotroxtunordovora.colty: Cardiology. (mondmilksevemengeotroxtunordovora.co)
  • Myocardial infarction by complete thrombosis of the left main coronary artery: Emergency treatment with angioplasty with implantation of a coronary stent and follow-up at one year: A case report. (mondmilksevemengeotroxtunordovora.co)
  • Jul 01, · Multivessel coronary disease is relatively common in patients with ST-segment elevation myocardial infarction (STEMI), with a reported prevalence ranging from 50% to 80% in selective populations.1, 2 Although multiple ruptured plaques with thrombus formation have been reported in more than 10% of autopsied cases, 3 concomitant thrombosis and. (mondmilksevemengeotroxtunordovora.co)
  • In this paper, we present a patient who underwent multivessel bifurcation stent placement after an acute inferior myocardial infarction over a period of one week, with sudden subacute stents thrombosis of the two drug-eluting stents in the left anterior descending and the circumflex coronary arteries, leading to death. (elsevier.com)
  • The relative risk of thrombosis with drug eluting stents and acute myocardial infarction is 8.11 (CI 95%2.32-28.31) p=0,001. (uthscsa.edu)
  • CONCLUSIONS: there is an increased incidence of thrombosis of coronary stents in the real world and a greater risk of thrombosis with drug eluting stents, especially when implanted in the context of an acute myocardial infarction. (uthscsa.edu)
  • Acute myocardial infarction typically resulting from an occlusion or obstruction of a coronary artery and characterized by sudden, severe pain in the chest that often radiates to the shoulder, arm, or jaw. (dictionary.com)
  • the 1950s and 1960s debate raged as to whether coronary thrombosis was the cause or the consequence of ST-segment elevation myocardial infarction (STEMI). (gasyblog.com)
  • The coronary sinus is the venous counterpart to the coronary arteries, where de-oxygenated blood returns from heart tissue. (wikipedia.org)
  • a heart disease caused by blockage of one of the coronary arteries. (thefreedictionary.com)
  • A 1976 autopsy preparation comprising sections of coronary arteries from six different individuals who died from ischaemic heart disease. (thenakedscientists.com)
  • The ANGIOJET Ultra Thrombectomy System is a mechanical thrombectomy device for PCI patients with large thrombus burden and the ONLY FDA-approved mechanical thrombectomy device for removal of thrombus in coronary arteries. (bostonscientific.com)
  • Dr. Osborn is a pathologist who has examined carefully and thoughtfully many coronary arteries in humans who died of cardiac disease, as well as accidents or other noncardiac causes. (annals.org)
  • Coronary Artery Disease occurs when the coronary arteries, the blood vessels that bring blood, oxygen, and nutrients to you heart, become damaged. (thirdage.com)
  • The narrowing of the arteries that occurs in coronary artery disease can result in chest pain (angina) and shortness of breath among other symptoms. (thirdage.com)
  • Coronary artery disease is caused by the hardening of the arteries, which is also known as atherosclerosis. (thirdage.com)
  • People experiencing this blockage in the arteries caused by coronary occlusions will typically experience the symptoms of a heart attack immediately. (planetdrugsdirect.com)
  • Anyone with narrowing of the arteries due to high cholesterol is at a high risk for developing coronary thrombosis. (planetdrugsdirect.com)
  • Coronary thrombosis is a condition that leads to heart attack, however, and not the heart attack that occurs after a blood clot develops in the arteries. (planetdrugsdirect.com)
  • This coronary blood vessels also include your guarantee coronary thrombosis arteries and, tiny arteries this connect the standard coronary thrombosis arteries and with each other. (global-medicalsearch.com)
  • What makes my own coronary arteries and critical? (global-medicalsearch.com)
  • Cardiac catheterization a further 4 months later documented no further filling defect in the LAD branch and the coronary arteries appeared free of disease. (sun.ac.za)
  • Despite the low incidence of blood clot formation in a stent - a tube of metal mesh with the appearance of chicken wire, which is placed in the main coronary arteries - it has major consequences for patients. (maastrichtuniversity.nl)
  • So it does appear to be a very important part of … Thrombosis of coronary arteries occurs when the opening or even the lumen, of the artery that becomes so small that the blood flow through the narrowed segment slows, allowing the blood to clot in the artery. (bethanystruble.com)
  • Arterial thrombosis can occur in the arteries that supply blood to the heart muscle (coronary arteries). (bethanystruble.com)
  • Sometimes a coronary angioplasty isn't possible, for example if the blockages in your arteries are too long for a stent or they're difficult to get to, and you may be offered a coronary artery bypass graft (CABG) instead. (bethanystruble.com)
  • The cause of a coronary thrombosis is sclerosis of the coronary arteries. (illadult.com)
  • With smoking, obesity, lack of exercise, raised blood pressure, raised levels of cholesterol and diabetes the speed with which sclerosis of the coronary arteries occurs increases. (illadult.com)
  • Coronary Thrombosis is one of the major heart diseases occurring due to blood clots in the coronary arteries of the heart. (thrombosisdisease.com)
  • The human heart is bounded by 3 chief coronary arteries, which are responsible in supplying the heart with oxygen and blood. (thrombosisdisease.com)
  • Simultaneous subacute stent thrombosis of two drug-eluting stents in the left anterior descending and the circumflex coronary arteries. (elsevier.com)
  • A resin cast of the aortic root, right and left coronary arteries. (thenakedscientists.com)
  • Transverse images of the coronary aorta (1 mm) were obtained along the major axis of the right coronary aorta (RCA), left anterior descending (LAD) and left circumflex (LCx) arteries. (biomedcentral.com)
  • The reason coronary arteries block off is due to them becoming narrowed over many years by a gradual build-up of fatty cholesterol-based material called atheroma within their walls. (netdoctor.co.uk)
  • Clinical signs of MI or angina if coronary thrombus is symptomatic: Imaging modalities used to evaluate the presence of coronary thrombi: angioscopy endocoronary ultrasound coronary angiography magnetic resonance imaging (MRI) Postmortem examiners may look for Lines of Zahn, to determine whether blood clotted in the heart vessels before or after death. (wikipedia.org)
  • Coronary angiography is limited to determination of the causes of thrombosis. (springer.com)
  • Methods and Results- We studied 1676 men and 465 women consecutively undergoing coronary angiography. (ahajournals.org)
  • From 1983 to 1992, 2141 of the 4754 patients admitted to our coronary division underwent coronary angiography as part of the clinical work-up of symptoms or signs of heart disease. (ahajournals.org)
  • Angiographic follow-up was scheduled from 6 to 8 months after PCI by coronary angiography, but was performed earlier if ischemia was indicated clinically. (ahajournals.org)
  • Coronary angiography revealed right coronary artery (RCA) stenosis and a drug eluting stent was deployed. (hindawi.com)
  • Methods: From May 2005, to May 2011 we identified all PCIs for proximal, one-vessel coronary artery disease in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). (diva-portal.org)
  • An early coronary angiography, performed after electrocardiography, the evaluation of cardiac enzymes and echocardiography, was carried out and revealed a diffuse coronary artery ectasia, involving particularly the right coronary artery. (ovid.com)
  • In conclusion, in this case, computed tomography played an additional and complementary role to coronary angiography. (ovid.com)
  • Objectives This study sought to determine clinical, procedural, and treatment factors associated with acute stent thrombosis (AST) in the EUROMAX (European Ambulance Acute Coronary Syndrome Angiography) trial. (onlinejacc.org)
  • An eccentric thrombus along the inferior wall of the left anterior descending artery suspected at transthoracic echocardiography was confirmed by coronary computed tomography angiography scan, without significant segmental stenosis. (biomedsearch.com)
  • Coronary angiography was performed because her chest pain continued despite medical treatment. (who.int)
  • Angiography showed that the left coronary system was normal but the distal portion of the right coronary artery was totally occluded by a thrombus ( Figure 1 ). (who.int)
  • Angiography showed hyperacute stent thrombosis (ST), with new thrombus adhered and TIMI II flow. (credoweb.ro)
  • Very late stent thrombosis could be the cause of the first occlusion, triggering the event in the other vessel. (hindawi.com)
  • This indicates that sudden coronary occlusion is often preceded by a variable period of plaque instability and thrombus formation, initiated days or weeks before onset of symptoms. (ahajournals.org)
  • Fukuhara S, Takase E, Fujimoto T, Takami Y, Yamamoto K, Nishida T, Morimoto A (2005) Coronary ectasia resulting in thrombotic coronary occlusion after warfarin interruption: a case report. (springermedizin.de)
  • However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. (clinsci.org)
  • A coronary occlusion may cause signs of discomfort before a heart attack occurs. (planetdrugsdirect.com)
  • People experiencing shortness of breath or chest pains, commonly called angina , may be experiencing the early warning symptoms of coronary occlusion. (planetdrugsdirect.com)
  • The name for this is "occlusion of the coronary artery" or "coronary occlusion. (seleneriverpress.com)
  • As an admitting physician during the last war, I had the chance to observe many coronary occlusion cases. (seleneriverpress.com)
  • The operator decided to begin the procedure with a 6F JR-4 guiding catheter, as suspected occlusion of right coronary artery. (credoweb.ro)
  • Jun 28, · The second one was the coronary artery bypass graft surgery (the coronary artery bypass grafting may represent a high risk of early occlusion because of normal native coronary flow after dissolving the coronary thrombus with medical therapy) and the third one was pharmacological strategy (thrombolytic therapy), eventually followed by the Cited by: 2. (mondmilksevemengeotroxtunordovora.co)
  • Coronary occlusion. (thefreedictionary.com)
  • The most important mechanism underlying the sudden onset of acute coronary syndrome (ACS) is plaque rupture and erosion of coronary atherosclerotic plaques followed by total or subtotal of coronary artery occlusion due to thrombus formation. (healthcare-bulletin.com)
  • Since then we have seen marked changes in the management of patients with STEMI.1 2 3 4 In 1980 DeWood and colleagues5 reported that about 80% of patients with acute MI had coronary occlusion measured using coronary arteriography and that the occlusion was due to an intraluminal thrombus. (gasyblog.com)
  • Background: Percutaneous coronary intervention (PCI) of lesions in the proximal left anterior descending coronary artery (LAD) may confer a worse prognosis compared with the proximal right coronary artery (RCA) and left circumflex coronary artery (LCX). (diva-portal.org)
  • In addition, the following day the patient underwent contrast-enhanced cardiac 64-slice computed tomography, which revealed the presence of an intraluminal thrombus in the distal tract of the right coronary artery. (ovid.com)
  • Spontaneous thrombosis in an ectatic right coronary artery -- Chongprasertpon et al. (bmj.com)
  • Coronary angiogram of the right coronary artery showing an ectatic vessel with a heavy thrombotic burden. (bmj.com)
  • Coronary angiogram of the right coronary artery in the left anterior oblique projection. (bmj.com)
  • Although there were any clinical or electrocardiographic facts to support it, right coronary artery was catheterized once again due to the maintained hypotensionepisode. (credoweb.ro)
  • He presented combined thrombosis of the distal anterior descending coronary artery and proximal right coronary artery, and was treated with sequential primary percutaneous coronary interventions and implantation of drug-eluting stents, but required two interventions due to high thrombotic load. (revportcardiol.org)
  • Some areas of focus: Coronary thrombosis can be a complication associated with drug-eluting stents. (wikipedia.org)
  • Stent thrombosis in drug-eluting or bare-metal stents in patients receiving dual antiplatelet therapy. (springer.com)
  • Bangalore S, Toklu B, Amoroso N, Fusaro M, Kumar S, Hannan EL, Faxon DP, Feit F. Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis. (springer.com)
  • Kang S-H, Chae I-H, Park J-J, Lee HS, Kang D-Y, Hwang S-S, Youn T-J, Kim H-S. Stent thrombosis with drug-eluting stents and bioresorbable scaffolds: evidence from a network meta-analysis of 147 trials. (springer.com)
  • Reason for posting: The use of coronary stents has improved the results of percutaneous coronary revascularization procedures. (cmaj.ca)
  • Along with newer antithrombotic therapy using glycoprotein IIb/IIIa platelet inhibitors, stents are used frequently in the management of acute coronary syndromes. (cmaj.ca)
  • We evaluated restenosis, stent thrombosis (ST) and mortality in the LAD as compared to the RCA and LCX according to stent type, bare metal (BMS) or drug-eluting stents (DES). (diva-portal.org)
  • Stone GW, Moses JW, Ellis SG et al (2007) Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. (springer.com)
  • Mauri L, Hsieh WH, Massaro JM et al (2007) Stent thrombosis in randomized clinical trials of drug-eluting stents. (springer.com)
  • Iakovou I, Schmidt T, Bonizzoni E et al (2005) Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. (springer.com)
  • Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. (ovid.com)
  • It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents (EES). (ovid.com)
  • We assessed the risk of stent thrombosis in a cohort of 12 339 patients with unrestricted use of drug-eluting stents (3819 SES, 4308 PES, 4212 EES). (ovid.com)
  • Current treatment with EES is associated with a lower risk of very late stent thrombosis compared with early-generation drug-eluting stents. (ovid.com)
  • What a difference a few years, and a new generation, has meant for the fortunes of drug-eluting coronary stents. (wordpress.com)
  • In the late summer of 2006, at that year's meeting of the European Society of Cardiology , the specter of stent thrombosis first rose around the drug eluting coronary stents of that era, the sirolimus- and paclitaxel-eluting devices. (wordpress.com)
  • The meta-analysis pooled results from two head-to-head comparisons of the cobalt-chromium everolimus-eluting stent against a bare-metal stent in a total of about 3,800 patients (including the EXAMINATION population), and found that the everolimus-eluting device cut the 1-year thrombosis rate by 86% and the 2-year rate by 65% compared with bare-metal stents. (wordpress.com)
  • Objectives: The aim of this study was to ascertain the 1-year incidence of stent thrombosis (ST) and major bleeding (MB) in a large, unselected population treated with sirolimus-eluting stents (SES). (elsevier.com)
  • Coronary artery stents, particularly drug-eluting stents, are used in the majority of patients who undergo percutaneous coronary intervention (PCI) to improve symptoms in patients with obstructive coronary artery disease. (bethanystruble.com)
  • OBJECTIVES: determine the incidence of thrombosis between bare metal stents versus drug-eluting stents in patients in the «real world» METHODS: incidence study to determine the number of cases of thrombosis in implanted stents through information gathered from clinical records, data bases and clinical follow-up, based on demographic characteristics, risk factors, clopidogrel treatment and events of stent thrombosis with a 0 days to 1 year follow-up. (uthscsa.edu)
  • 12 thrombosis events were identified (7 with drug-eluting stents and 5 with bare metal stents). (uthscsa.edu)
  • The incidence of thrombosis with drug-eluting stents was 3.55% (CI 95%1.43-7.32), and with bare metal stents 1.13% (CI 95% 0.37-2.64) p=0.000. (uthscsa.edu)
  • The relative risk of thrombosis with drug eluting stents is 3.14 (CI 95%1.01-9.78) p=0.037. (uthscsa.edu)
  • The patient had been previously submitted to percutaneous coronary angioplasty with bare metal stent implantation in both culprit vessels. (hindawi.com)
  • During angioplasty , the catheter is advanced into the narrowed part of the coronary artery. (freemd.com)
  • 5 The emerging consensus suggests that, when possible, surgery should be delayed for at least 1 week following percutaneous transluminal coronary angioplasty (PTCA) without stent placement, with the recommended delay being extended to at least 4-6 weeks for BMS and for at least 12 months following DES placement. (apsf.org)
  • Our study provided an objective experimental demonstration of the low accuracy of arteriography for detection of mural thrombosis after angioplasty. (antimicrobialmed.com)
  • Coronary thrombosis is most commonly caused as a downstream effect of atherosclerosis, a buildup of cholesterol and fats in the artery walls. (wikipedia.org)
  • Atherosclerosis contributes to coronary thrombosis formation by facilitating blood stasis as well as causing local endothelial injury. (wikipedia.org)
  • Whether this protection is based on a lesser degree of coronary atherosclerosis has not been established. (ahajournals.org)
  • Conclusions- In a selected high-risk population, moderate alcohol consumption was independently associated with less coronary atherosclerosis and lower risk for cardiac mortality. (ahajournals.org)
  • This prompted the present study, in which the association of alcohol consumption with angiographically quantified coronary atherosclerosis was analyzed in a large cohort of men and women, in whom information on classical CVD risk factors and clinical outcome was available. (ahajournals.org)
  • High levels of LDL cholesterol, also known as "bad cholesterol", contribute to atherosclerosis, the hardening of artery walls that can lead to coronary artery disease. (thirdage.com)
  • Background In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. (onlinejacc.org)
  • Coronary thrombosis Valentin Fuster, John T Fallen, Yale Nemerson The past few years have witnessed a remarkable advance in our understanding of the pathophysiology of coronary atherosclerosis. (bethanystruble.com)
  • The past few years have witnessed a remarkable advance in our understanding of the pathophysiology of coronary atherosclerosis.1-3 Others in this Supplement review the types of atherosclerotic lesions and the mechanisms of progression with plaque instability and disruption, and record how the lesions can be stabilised or even made to regress. (mondmilksevemengeotroxtunordovora.co)
  • any improvement in survival statistics were more likely due to prevention of thromboembolic complications (e.g. fatal pulmonary embolism) than in the treatment of the offending coronary artery thrombus itself, and the risk of bleeding sometimes life-threatening, was another consideration. (positivehealth.com)
  • It is early in the morning, and I have just had one of those tragic cases of coronary thrombosis. (seleneriverpress.com)
  • A tentative grouping of the cases of coronary thrombosis based on clinical symptoms was made: Cases of instantaneous death, a group graphically described … Many of the risk factors for venous and arterial thrombosis are the same. (bethanystruble.com)
  • A review of cases of coronary thrombosis served as the basis for the material presented in this article. (mondmilksevemengeotroxtunordovora.co)
  • There are numerous treatments currently being studied for management and prevention of coronary thrombosis. (wikipedia.org)
  • The prediction and prevention of coronary thrombosis in the younger age groups, a suggestion for further study. (wizdom.ai)
  • citation needed] To address the possibility of identifying and treating asymptomatic coronary artery disease to prevent development of coronary thrombosis, the COURAGE trial was published in 2018. (wikipedia.org)
  • Patients were eligible if they had disease of a native coronary artery (i.e., those with diseased grafts were excluded) in the setting of stable or unstable angina, or silent ischemia. (cmaj.ca)
  • Thought you might appreciate this item(s) I saw at Coronary Artery Disease. (lww.com)
  • This latter case control study was prompted by the demonstration in the GeneQuest study that three polymorphisms in the THBS-1, -2, and -4 genes might influence the risk of premature coronary artery disease (CAD) or MI. (ahajournals.org)
  • Perhaps a more accurate title would have been "Pathogenesis of Coronary Disease. (annals.org)
  • Coronary artery disease is the most common type of heart disease. (thirdage.com)
  • High blood pressure puts added stress onto the coronary artery walls, making the development of coronary artery disease more likely. (thirdage.com)
  • Percutaneous coronary intervention (PCI) is widely performed for the treatment of obstructive coronary artery disease (CAD) with good results [ 1 , 2 ]. (hindawi.com)
  • The patient was not on any medications and had no family history of coronary artery disease or sudden death. (hindawi.com)
  • We included 2,178 consecutive patients with coronary artery disease who underwent intracoronary stent implantation, 789 (36.2%) with HPA-3a/a, 1,023 (47.0%) with HPA-3a/b, and 366 (16.8%) with HPA-3b/b genotype. (nih.gov)
  • 70% stenosis) coronary artery disease proximal to the culprit lesion were the strongest predictors of ST. (onlinejacc.org)
  • Objective- To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women. (ahajournals.org)
  • 14-16 IL-8 plasma levels are higher in patients with unstable coronary artery disease (CAD) than in healthy controls, 17-20 but these measurements were all obtained after an acute coronary syndrome that may have affected these levels substantially. (ahajournals.org)
  • To explore effective and convenient rescue therapy options for coronary artery aneurysms (CAA) with thrombosis in Kawasaki disease (KD). (springermedizin.de)
  • Durongpisitkul K, Gururaj VJ, Park JM, Martin CF (1995) The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment. (springermedizin.de)
  • Predictive value of serum lipid for intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease. (onmedica.com)
  • While intravascular imaging was not used, the angiographic appearances with a lack of coronary atheroma in the culprit vessel and the absence of bystander disease in this patient with no cardiovascular risk factors suggested that this was not plaque rupture. (bmj.com)
  • She had no risk factors for coronary artery disease in her medical history but it was learned that she had undergone a mitral valve replacement 2 years before because of rheumatic mitral stenosis and that no international normalized ratio (INR) analysis had been done in the last 6 months. (who.int)
  • The risk factors of coronary disease include using tobacco products or being exposed to secondhand smoke, having a family history of heart attack, high cholesterol and being diagnosed with diabetes . (planetdrugsdirect.com)
  • Embolic sequela of an intra-abdominal infectious process and recently, Crohn's disease [11] is also reported to be associated with spontaneous coronary sinus thrombosis. (statpearls.com)
  • Coronary artery disease (CAD) reduces the flow of blood to your heart. (bethanystruble.com)
  • It is very important to get thrombosis treatment and diagnosis for blood clot, once a person detects any thrombosis disease or symptoms. (thrombosisdisease.com)
  • The exact mechanism of valve disease in APS is not fully understood, but the current belief is that there is an interaction between valve antigen and antiphospholipid antibodies which result in the observed thrombosis and valve thickening [4]. (peertechz.com)
  • Background Thromboembolic disease is a well-recognized complication of Ulcerative Colitis (UC), but coronary involvement is rare. (henryford.com)
  • It is different from coronary artery disease, which affects the heart's blood vessels. (medicalnewstoday.com)
  • When talking about heart conditions, doctors use the terms coronary heart disease (CHD) and the broader cardiovascular disease (CVD). (netdoctor.co.uk)
  • ︉ CVD refers to both coronary heart disease and diseases of the circulation, such as stroke , when a clot blocks blood supply to the brain. (netdoctor.co.uk)
  • There is often no obvious cause for it, although coronary heart disease and high blood pressure, viral infections, excessive alcohol intake and thyroid disease can all be triggers. (netdoctor.co.uk)
  • Most heart attacks are the result of coronary heart disease. (netdoctor.co.uk)
  • Coronary sinus thrombosis as a severe complication after procedures. (wikipedia.org)
  • Stent thrombosis is a rare complication of percutaneous coronary intervention and carries a poor prognosis. (springer.com)
  • Acute stent thrombosis is an unusual complication after PCI [ 3 ]. (hindawi.com)
  • Stent thrombosis is an infrequent but devastating complication after stent implantation. (apsf.org)
  • Although coronary embolism due to mechanical valve thrombosis is encountered rarely, it is an important and serious complication. (who.int)
  • Mechanical valve thrombosis is a serious complication [2-4]. (who.int)
  • Coronary sinus thrombosis is a rare and severe condition that is usually a post-procedural complication following invasive right heart instrumentation [1] . (statpearls.com)
  • Coronary air embolism is a rare complication of cardiac catheterization with a known incidence of 0.1% to 0.3% of all the procedures. (credoweb.ro)
  • Significant coronary air embolism is an unusual complication of any catheterization, caused mainly by a loss of the integrity in the closed system that forms the patient's artery and the injector pump. (credoweb.ro)
  • Stent Thrombosis (ST) is also a rare complication of PCI but associated with severe morbidity and mortality, especially in the setting of acute coronary syndrome. (credoweb.ro)
  • Stent thrombosis (ST) occurring after PCI is a rare but serious complication. (healthcare-bulletin.com)
  • however, autopsy studies investigating the pathogenesis of the "vulnerable plaque" in patients who had witnessed sudden cardiac death identified signs of old thrombosis, which indicates that plaque complications remain clinically silent days or weeks before the fatal event. (ahajournals.org)
  • Repeat cardiac catheterization showed an acute in-stent thrombosis. (hindawi.com)
  • Repeat cardiac catheterization showed an acute thrombosis of the initially placed stent. (hindawi.com)
  • 2 Non-cardiac surgery performed following recent stent placement poses an additional risk of thrombosis due to the inherent hypercoagulable state of surgery as well as the common practice of discontinuing antiplatelet therapy perioperatively. (apsf.org)
  • If your coronary thrombosis bloodstream can't dilate adequately, ones cardiac muscle may not be able to uncover the volume of fresh air it needs to function appropriately. (global-medicalsearch.com)
  • Once the cardiovascular system isn't getting plenty of breathable oxygen-vibrant maintain through the coronary thrombosis bloodstream, the particular disturbed cardiac muscle can certainly deteriorate as well as cease to live. (global-medicalsearch.com)
  • In at least few of these, the possibility that thrombosis of the coronary sinus could be associated with cardiac death remains unanswered. (statpearls.com)
  • The first major system is the coronary sinus which receives approximately 60% of the total cardiac venous return from posterior myocardium via several tributaries and opens into the right atrium. (statpearls.com)
  • Therefore, considering these anastomotic connections between the coronary sinus and the anterior cardiac veins, and the drainage capability of the thebesian veins, coronary sinus thrombosis would, at least theoretically, appear to be a relatively benign entity, but it is not. (statpearls.com)
  • Favara BE, Franeiosu RA, and Butterfield L J: Dissemi- nated intravascular and cardiac thrombosis of the neonate, Am J Dis Child , 4. (mondmilksevemengeotroxtunordovora.co)
  • Evidence remains inconclusive about whether these risks outweigh the benefit of a coronary arterial stent. (wikipedia.org)
  • COVID-19 is associated with increased incidence of venous and arterial thrombosis, including coronary artery thrombosis in patients with no underlying cardiovascular risk factors. (bmj.com)
  • This coronary arterial blood vessels supply our blood to your heart muscle, providing a continuing method of getting air and also nutritional value necessary for this to stay nutritious plus functionality normally. (global-medicalsearch.com)
  • The leading technique to improve the fresh air source to the heart would be to raise the circulation of blood from the coronary arterial blood vessels. (global-medicalsearch.com)
  • Each time a coronary artery results in being blocked, though, equity coronary arterial blood vessels aid in increasing the particular blood circulation to the section of the heart that is certainly staying without the benefit of blood flow. (global-medicalsearch.com)
  • Certain conditions … Find out more about the causes and risk factors for developing arterial thrombosis. (bethanystruble.com)
  • Arterial Thrombosis.The main types of arterial thrombosis are related to arteriosclerosis, although thrombosis can also result from infection or from injury to an artery.Arteriosclerosis may be hereditary or may be brought on by diabetes mellitus. (bethanystruble.com)
  • Treatment options for arterial thrombosis include either relatively old drugs such as streptokinase, and newer agents that are either approved by the FDA or still undergoing clinical trials. (benthambooks.com)
  • The present study shows that encroachment of about one fourth of the arterial lumen is a minimal necessary condition for thrombosis to appear on the arteriogram in this model. (antimicrobialmed.com)
  • Late stent thrombosis after the use of a bioresorbable vascu. (lww.com)
  • The presence of intracoronary thrombus and atheromatous plaque constituents may lead to distal embolization and the "no-reflow" phenomenon after percutaneous coronary intervention (PCI), 6 both associated with poor clinical outcome. (ahajournals.org)
  • Loss of distal right coronary perfusion highlighted with black asterisks. (bmj.com)
  • Intracoronary vasodilators improved distal coronary flow. (henryford.com)
  • Readers will learn about the pathogenesis and diagnosis of thrombosis, thrombogenesis and fibrinolysis. (benthambooks.com)
  • The combination of in vivo MRI and comparison with histopathology images of rabbit coronary thrombus may be a research tool for understanding of the pathogenesis of acute coronary plaques. (biomedcentral.com)
  • However, they may actually lead to an increased coronary thrombus formation due to increased tissue factor expression and delayed healing within the vessels. (wikipedia.org)
  • rLj-RGD3 significantly reduced ST segment elevation, prevented thrombus formation in the coronary artery and decreased Evans blue content in the left ventricular myocardium. (deepdyve.com)
  • Leading risk factors for coronary thrombosis are high LDL cholesterol, smoking, sedentary lifestyle, and hypertension. (wikipedia.org)
  • By employing OCT, a number of pathologies such as malapposition, rupture of neoatherosclerosis, uncovered struts, restenosis, evagination, underexpansion, and dissection of the borders have been identified as risk factors for coronary stent thrombosis, allowing causal and specific treatments. (springer.com)
  • Clinical presentation of stent thrombosis (ST) and its sequela under contemporary practice have not been fully elucidated largely due to rare incidence of ST. We sought to assess the characteristics in patients with clinical presentation of ST and their in-hospital outcomes, utilizing nationwide registration system for percutaneous coronary interventions (J-PCI). (onmedica.com)
  • 3 While the European Association of Percutaneous Cardiovascular Interventions advises emergency reperfusion in STEMI with COVID-19, 4 the optimal strategy to manage coronary thrombosis in the absence of plaque rupture is yet to be determined. (bmj.com)
  • Massive coronary air embolism and intraprocedural stent thrombosis are a very infrequent but live-threatening complications of coronary interventions. (credoweb.ro)
  • Clinical end points in coronary stent trials: a case for standardized definitions. (springer.com)
  • Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. (springer.com)
  • 5 Although it is unclear whether the rate of stent thrombosis that is being detected in clinical practice is higher than that observed in the pre-approval clinical trials, the manufacturer issued a warning letter to US physicians on July 7. (cmaj.ca)
  • The clinical features of the pericarditis found during the course of some cases of acute coronary artery thrombosis have been recently reviewed by Blumer 1 who rejuvenated the term pericarditis epistenocardica first applied to this condition in 1910 by Sternberg. (annals.org)
  • 2 In 1872 Baumler 3 gave the first clinical picture of pericarditis epistenocardica , though he was not aware of the relation of the condition he described to acute coronary artery thrombosis and in fact dubbed the pericarditis "idiopathic. (annals.org)
  • Cutlip DE, Baim DS, Ho KK et al (2001) Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trial. (springer.com)
  • Neither clinical features nor laboratory data could reliably predict CAA associated thrombosis. (springermedizin.de)
  • The present study included acute coronary syndrome (ACS) patients undergoing PCI with clinical findings of definite ST from January 2014 to December 2016. (onmedica.com)
  • These results show that rLj-RGD3 can effectively reduce coronary thrombosis in AMI rats by strongly inhibiting platelet function, indicating that the recombinant RGD toxin protein rLj-RGD3 may serve as a potent clinical therapeutic agent for AMI. (deepdyve.com)
  • It is likely that coronary sinus thrombosis is under-recognized because of the rapid deterioration of these patients and limited overall clinical experience of cardiologists with this condition. (statpearls.com)
  • The clinical and angiographic outcomes of 10 patients' who received abciximab as part of their therapy for early stent thrombosis was compared with 25 patients (using historical controls) who received conventional therapy. (elsevier.com)
  • The handbook combines available information from basic hematology, cardiology and clinical trials and presents practical bed-side solutions for clinicians working with patients suffering from acute coronary syndromes. (benthambooks.com)
  • We report this first clinical case of simultaneous massive coronary air embolism and stent thrombosis. (credoweb.ro)
  • Thrombosis Canada is pleased to share two new clinical guides, as well as an educational slide deck on Acute Coronary Syndrome In Hospital Antiplatelet Management. (thrombosiscanada.ca)
  • The two new clinical guides can now be accessed through our website and focus on ST Elevation and Non-ST Elevation Acute Coronary Syndrome: Hospital Antiplatelet Management. (thrombosiscanada.ca)
  • Coronary Thrombosis Global Clinical Trials Review, H1, 2019" provides an overview of Coronary Thrombosis clinical trials scenario. (marketresearch.news)
  • This report provides top line data relating to the clinical trials on Coronary Thrombosis. (marketresearch.news)
  • These patients and their outcomes may be more representative of patients with typical acute coronary syndromes undergoing stenting in clinical practice. (scripps.edu)
  • In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology , Boekholdt et al 7 provide further evidence that homozygosity for the less common T-allele resulting from a thymidine-to-guanine substitution in the 3′ untranslated region (3′ UTR) of the THBS-2 gene is associated with reduced risk of premature MI. (ahajournals.org)
  • Rosales, Oscar R. / Timing of coronary stent thrombosis in patients treated with prophylactic tirofiban . (utmb.edu)
  • Moreno R, Fernandez C, Hernandez R et al (2005) Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. (springer.com)
  • The cobalt-chromium everolimus-eluting model also significantly surpassed every other first- and second-generation drug-eluting stent for their 1-year rate of definite stent thrombosis. (wordpress.com)
  • Background: Stent thrombosis and MB are major potential complications of drug-eluting stent implantation. (elsevier.com)
  • coronary thrombosis synonyms, coronary thrombosis pronunciation, coronary thrombosis translation, English dictionary definition of coronary thrombosis. (bethanystruble.com)
  • Thrombotic coronary debris highlighted with black arrow. (bmj.com)
  • Among patients undergoing coronary artery surgery, the administration of preoperative aspirin resulted in neither a lower risk of death or thrombotic complications nor a higher risk of bleeding than that with placebo. (tomhsiung.com)
  • Conclusion Acute coronary thrombosis in pro-inflammatory states are challenging to treat, since both the underlying condition and treatment of UC are pro-thrombotic. (henryford.com)
  • Acute and subacute stent thromboses (ASST) are the major thrombotic complications of coronary stenting. (utmb.edu)
  • Objectives The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography. (onlinejacc.org)
  • Recent improvements in stent technology and new antiplatelet therapies have reduced the incidence of stent thrombosis. (springer.com)
  • The incidence of stent thrombosis was 1.7% in HPA-3a/a, 1.7% in HPA-3a/b, and 1.6% in HPA-3b/b patients (p = 0.999). (nih.gov)
  • Despite improved stent implantation technologies and more effective antiplatelet regimens, stent thrombosis (ST) continues to occur with an estimated incidence varying between 1% and 5% ( 1-6 ). (onlinejacc.org)
  • Incidence and In-Hospital Outcomes of Patients Presenting With Stent Thrombosis (from the Japanese Nationwide Percutaneous Coronary Intervention Registry). (onmedica.com)
  • The incidence of thrombosis with any kind of stent was 1.88 %( CI 95% 0.97-3.28). (uthscsa.edu)
  • Obstruction of a coronary artery by a thrombus, often leading to destruction of heart muscle. (dictionary.com)
  • Treatment options include: emergency coronary artery bypass grafting (CABG) stent implantation intracoronary thrombolysis anticoagulation with heparin or glycoprotein IIb/IIIa inhibitors thrombus aspiration as reperfusion strategy platelet P2Y12 receptor inhibitors: The CURE trial in 2001 determined that the addition of clopidogrel showed a positive effect on cardiovascular mortality, non-fatal MI, and stroke at the cost of an increased risk of major bleeding. (wikipedia.org)
  • Later studies showed that the coronary thrombus could be dissolved with intracoronary (and later intravenous) administration of streptokinase and a meta-analysis demonstrated a reduction in mortality. (gasyblog.com)
  • Increased levels of inflammation may lead to higher risk of clotting as well as an increased risk of stent/device subsequent thrombosis. (wikipedia.org)
  • Statin drugs, in addition to their primary cholesterol-lowering mechanisms of action, have been studied to target a number of pathways that may decrease coronary inflammation and subsequent thrombosis. (wikipedia.org)
  • Symptoms of this disorder include vascular thrombosis without inflammation in the vessel wall, premature birth, spontaneous abortion, and death in a morphologically normal fetus at or beyond the 10th week of gestation [1]. (peertechz.com)
  • These options make some room for questions that lead to a conclusion for the best combination of drugs for treating patients with acute coronary syndromes. (benthambooks.com)
  • We studied stent thrombosis in 4,607 patients with acute coronary syndromes who received a coronary stent as part of routine care during 2 trials of aspirin versus sibrafiban for secondary prevention. (scripps.edu)
  • The mechanism of acute coronary syndromes is understood due to the disruption of an atherosclerotic coronary plaque with an overlying thrombus [3a, 3b, 4]. (biomedcentral.com)
  • citation needed] The formation of coronary thrombosis generally follows the same mechanism as other blood clots in the body, the coagulation cascade. (wikipedia.org)
  • Now, going back in my own personal history, let me tell you of my first observations concerning the blood, which resulted in my conclusions as to how to prevent thromboses, or blood clots. (seleneriverpress.com)
  • Decision-making LHC showed acute in-stent thrombosis. (henryford.com)
  • Coronary artery thrombosis can be caused by either plaque rupture or plaque erosion1. (pharmiweb.com)
  • Proteomics of coronary thrombus aspirates indicate that PEDF processing is associated with coronary plaque rupture. (clinsci.org)
  • Although plaque rupture followed by coronary thrombosis is known to precipitate acute MI, 22,23 its role has been debated extensively. (bethanystruble.com)
  • Wenaweser P, Rey C, Eberli FR et al (2005) Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome. (springer.com)
  • A drug-eluting coronary stent that's actually substantially safer than a bare-metal stent for the important safety endpoint of stent thrombosis. (wordpress.com)
  • Mechanical valve thrombosis causes embolism rarely. (who.int)
  • Other causes of coronary embolism include atrial fibrillation, left atrial tumours, bacterial endocarditis, atrial and ventricular mural thrombus, syphilis and pulmonary vein thrombosis [7]. (who.int)
  • There is no consensus regarding treatment of coronary embolism. (who.int)
  • Coronary embolism in the fetus, Circulation , 3. (mondmilksevemengeotroxtunordovora.co)
  • New article #workfromhome during #COVIDー19 Hospital acquired venous #thrombosis #VTE could ➡pulmonary embolism & identifying pts at risk is crucial. (thrombosiscanada.ca)
  • Methods: Fifteen dogs underwent left anterior descending coronary artery (LAD) injury in to produce thrombus, whereas 5 control dogs had LAD ligation. (elsevier.com)
  • In these patients, stent thrombosis occurred more often than in previous patients who underwent elective percutaneous coronary intervention. (scripps.edu)
  • In all animals, coronary aortic wall thickening and atheroma size was measured using MRI. (biomedcentral.com)
  • Frequency of plaques, plaque height in aorta and coronary artery atheroma was also assessed by histology. (biomedcentral.com)
  • Still coronary artery atheroma development and plaque constituents are not well documented. (biomedcentral.com)
  • In this patient population, therapy directed at reducing both thromboembolism (via oral anticoagulation) and stent thrombosis (via dual antiplatelet therapy) is necessary but is associated with an increased risk for bleeding. (biomedsearch.com)
  • 1 Some notable risk factors for stent thrombosis include the presence of bifurcation and small vessel lesions, suboptimal angiographic results, high-risk patients (i.e., diabetes mellitus and renal failure), and most importantly, cessation of dual antiplatelet therapy (i.e., aspirin and clopidogrel). (apsf.org)
  • The risk of perioperative bleeding associated with antiplatelet therapy must be weighed against the catastrophic event of stent thrombosis from discontinuation of antiplatelet therapy. (apsf.org)
  • The American Heart Association states that people who have suffered from coronary thrombosis may be given anticoagulants or antiplatelet medications that thin the blood along with other medications, such as diuretics to help remove sodium and fluid from the body, to prevent future occurrence and to help reduce the workload on the heart. (planetdrugsdirect.com)
  • Similar to thrombosis at any other sites, coronary sinus thrombosis results from a combination of venous stasis, alteration of the coagulation profile, and vessel wall injury, for example, endothelial damage. (statpearls.com)
  • Sepsis and disseminated coagulopathy play an additional role in precipitating spontaneous coronary sinus thrombosis. (statpearls.com)
  • Prior cases of coronary sinus thrombosis resulting from massive atrial thrombosis extending into the coronary sinus have also been reported. (statpearls.com)
  • The occurrence of coronary sinus thrombosis is rare, or at least rarely reported. (statpearls.com)
  • Considering the high number of the patients who undergo ventricular pacing via the coronary sinus with ventricular pacemakers, the lack of reports of coronary sinus thrombosis is often surprising. (statpearls.com)
  • However, some groups still using anticoagulants in acute coronary syndromes. (positivehealth.com)
  • We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may have caused plaque disruption in another already vulnerable vessel. (hindawi.com)
  • The aim was to establish the age of the aspirated thrombi to find in vivo pathological evidence of ongoing plaque disturbances and healing processes that occur before the acute occlusive thrombosis of the infarct-related coronary artery. (ahajournals.org)
  • OBJECTIVE To evaluate the prevalence of plaque erosion as a substrate for coronary thrombosis. (bmj.com)
  • p = 0.0004), the plaque substrate for thrombosis was erosion. (bmj.com)
  • Superficial plaque erosion causes up to one-third of all acute coronary syndromes2,[3]. (pharmiweb.com)