Coronary Stenosis: Narrowing or constriction of a coronary artery.Coronary Vessels: The veins and arteries of the HEART.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Microspheres: Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Perfusion Imaging: The creation and display of functional images showing where the blood flow reaches by following the distribution of tracers injected into the blood stream.Myocardial Perfusion Imaging: The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.Ecchymosis: Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Fractional Flow Reserve, Myocardial: The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.BooksAlgorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Sperm Midpiece: The middle piece of the spermatozoon is a highly organized segment consisting of MITOCHONDRIA, the outer dense fibers and the core microtubular structure.Dilatation: The act of dilating.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Molluginaceae: A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. Some members contain triterpenoid saponins.Swine, Miniature: Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).Nitrogen Radioisotopes: Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Multidetector Computed Tomography: Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.ArchivesKidney Neoplasms: Tumors or cancers of the KIDNEY.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Heart Transplantation: The transference of a heart from one human or animal to another.Calcinosis: Pathologic deposition of calcium salts in tissues.Biomedical Engineering: Application of principles and practices of engineering science to biomedical research and health care.Blogging: Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.

Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. (1/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. METHODS AND RESULTS: FFR and CFR were assessed in 126 consecutive patients with 150 intermediate coronary lesions (between 40% and 70% diameter stenosis by visual assessment). Agreement between outcomes of FFR and CFR, categorized at cut-off values of 0.75 and 2.0, respectively, was observed in 109 coronary lesions (73%), whereas discordant outcomes were present in 41 lesions (27%). In 26 of these 41 lesions, FFR was <0.75 and CFR>or=2.0 (group A); in the remaining 15 lesions, FFR was >or=0.75 and CFR<2.0 (group B). Minimum microvascular resistance, defined as the ratio of mean distal pressure to average peak blood flow velocity during maximum hyperemia, showed a large variability (overall range, 0.65 to 4.64 mm Hg x cm(-1) x s(-1)) and was significantly higher in group B than in group A (2.42+/-0.77 versus 1.91+/-0.70 mm Hg x cm(-1) x s(-1); P:=0.034). CONCLUSIONS: Our findings demonstrate the prominent role of microvascular resistance in modulating the relationship between FFR and CFR and emphasize the importance of combined pressure and flow velocity measurements to evaluate coronary lesion severity and microvascular involvement.  (+info)

Serial intravascular ultrasound analysis of the impact of lesion length on the efficacy of intracoronary gamma-irradiation for preventing recurrent in-stent restenosis. (2/1816)

BACKGROUND: The relation between lesion length and effectiveness of brachytherapy is not well studied. METHODS AND RESULTS: We compared serial (postintervention and follow-up) intravascular ultrasound findings in 66 patients with native coronary artery in-stent restenosis (ISR) who were treated with (192)Ir (15 Gy delivered 2 mm away from the radiation source). Patients were enrolled in the Washington Radiation for In-Stent Restenosis Trial (WRIST; ISR length, 10 to 47 mm; n=36) or Long WRIST (ISR length, 36 to 80 mm; n=30). External elastic membrane, stent, lumen, and intimal hyperplasia (IH; stent minus lumen) areas and source-to-target (intravascular ultrasound catheter to external elastic membrane) distances were measured. Postintervention stent areas were larger in WRIST and smaller in Long WRIST patients (P:<0.0001). At follow-up, maximum IH area significantly increased in both WRIST and Long WRIST patients (P:<0.0001 for both), but this increase was greater in Long WRIST patients (P:=0.0006). Similarly, minimum lumen cross-sectional area significantly decreased in both WRIST and Long WRIST patients (P:<0.05 and P:<0.0001, respectively), but this decrease was more pronounced in Long WRIST patients (P:=0.0567). The maximum source-to-target distance was longer in Long WRIST than in WRIST, and it correlated directly with ISR length (r=0.547, P:<0.0001). Overall, the change in minimum lumen area and the change in maximum IH area correlated with the maximum source-to-target distance (r=0.352, P:=0.0038 and r=0.523, P:<0.0001 for WRIST and Long WRIST, respectively). The variability (maximum/minimum) in IH area at follow-up also correlated with the maximum source-to-target distance (r=0.378, P:<0.0001). CONCLUSIONS: Brachytherapy may be less effective in longer ISR lesions because of the greater variability and longer source-to-target distances in diffuse ISR.  (+info)

Impact of peri-stent remodeling on restenosis: a volumetric intravascular ultrasound study. (3/1816)

BACKGROUND: Vessel remodeling is an important mechanism of late lumen loss after nonstent coronary interventions. However, its impact on in-stent restenosis has not been systematically investigated. METHODS AND RESULTS: Serial volumetric intravascular ultrasound analyses (poststent and follow-up) were performed in 55 lesions treated with a balloon-expandable stent (ACS MultiLink) using standard stent deployment techniques. The vessel volume (VV), lumen volume (LV), and volume bordered by the stent (SV) were measured using Simpson's method. The volume of plaque and neointima outside the stent (peri-stent volume, PSV) and volume of neointima within the stent (intrastent volume) were also measured. The change of each parameter during the follow-up period (follow-up minus poststent) was calculated and then divided by SV to normalize these values (designated as percent change [%]). As expected, %PSV directly correlated with %VV (P<0.0001, r=0.935), with no significant SV. A highly significant inverse correlation was seen between %PSV and the percent change of intrastent volume (P<0.0001, r=0.517). Consequently, %LV significantly correlated with peri-stent remodeling, as measured by %VV (P<0.0001, r=0.602). CONCLUSION: Positive remodeling of the vessel exterior to a coronary stent occurs to a variable degree after stent implantation. There is a distinct trade-off between positive remodeling and in-stent hyperplasia: in segments in which the degree of peri-stent remodeling is less, intrastent neointimal proliferation is greater and accompanied by more significant late lumen loss.  (+info)

Magnesium deficiency in patients with recent myocardial infarction and provoked coronary artery spasm. (4/1816)

This study sought to clarify the relationship between magnesium (Mg) deficiency and coronary artery spasm provoked by pharmacologic agents in patients with a recent acute myocardial infarction (AMI). Twenty-three consecutive patients suffering from AMI were investigated with a Mg retention test (Mg: 0.1 mmol/kg for 4 h) in both the acute phase (within I week (3+/-2 days) of onset) and the subacute phase (3-4 weeks (24+/-6 days) of the onset). Early coronary arteriography was performed in all patients. Coronary stenosis in the infarct-related artery was less than 90% in all patients in the subacute phase. The spasm provocation test was performed in the subacute phase and coronary spasm was defined as transient subtotal or total occlusion in association with angina or electrocardiographic ST-segment deviation. Coronary artery spasm was provoked in only 13 of the 23 patients. Compared with the control subjects (12 patients without coronary artery disease or coronary spasm), the 24-h Mg retention was significantly higher in patients with AMI (acute phase: 78+/-27%, subacute phase: 66+/-32%, vs control: 48+/-12%, p<0.05). In the subacute phase, the 24-h Mg retention decreased in patients without coronary spasm (43+/-26%), but a high level of Mg retention was still observed in patients with coronary spasm (84+/-25%). There was no difference in the serum concentrations of Mg, calcium and phosphorus between the 2 groups on both phases. In conclusion, both Mg deficiency and provoked coronary artery spasm were noted in more than half of the Japanese patients with a recent AMI, suggesting a close association between Mg deficiency and AMI.  (+info)

Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. (5/1816)

Infections are assumed to play a role in coronary artery disease (CAD) and cardiomyopathies. It is unknown whether the seroprevalence of antibodies to these microorganisms is higher in patients with than without CAD. The seroprevalence of antibodies to Bartonella henselae, Borrelia burgdorferi, Chlamydia pneumoniae, Coxiella burnetii, Helicobacter pylori, human granulocytic Ehrlichia, Leptospira, Rickettsia conorii, and Treponema pallidum was assessed prospectively in patients with exertional dyspnea or anginal chest pain who underwent coronary angiography because of suspected CAD. Patients with normal angiograms (NA) were those in whom no more than 50% stenosis of any coronary artery was found. Patients with CAD were patients who underwent percutaneous transluminal coronary angioplasty. There were 50 patients with CAD (9 female) and 62 with NA (25 female), with a mean age of 62 years. All patients had antibodies to at least one microorganism: to B. henselae, 8% of CAD patients and 5% of NA patients; to B. burgdorferi IgG, 14% CAD and 6% NA; to B. burgdorferi IgM, 6% CAD and 3% NA; to C. pneumoniae lipopolysaccharide (LPS) IgA, 76% CAD and 77% NA; to C. pneumoniae LPS IgG, 80% CAD and 90% NA; to C. burnetii, 0% CAD and 5% NA; to H. pylori, 92% CAD and 68% NA; to human granulocytic Ehrlichia, 8% CAD and 3% NA; to Leptospira IgG, 4% CAD and 2% NA; to R. conorii, 10% in both groups; and to T. pallidum, 2% CAD and 0% NA. The seroprevalence of antibodies to micro-organisms known to induce arterial and myocardial damage does not differ between patients with CAD and NA.  (+info)

Dobutamine stress echocardiography versus quantitative technetium-99m sestamibi SPECT for detecting residual stenosis and multivessel disease after myocardial infarction. (6/1816)

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN: Prospective study. SETTING: University hospital. METHODS: 75 patients underwent simultaneous DSE and mibi SPECT at (mean (SD)) 5 (2) days after a first acute myocardial infarct. Quantitative coronary angiography was performed in all patients after imaging studies. RESULTS: Significant stenosis (> 50%) of the infarct related artery was detected in 69 patients. Residual ischaemia was identified by DSE in 55 patients and by quantitative mibi SPECT in 49. The sensitivity of DSE and mibi SPECT for detecting significant infarct related artery stenosis was 78% and 70%, respectively, with a specificity of 83% for both tests. The combination of DSE and mibi SPECT did not change the specificity (83%) but increased the sensitivity to 94%. Mibi SPECT was more sensitive than DSE for detecting mild stenosis (73% v 9%; p = 0.008). The sensitivity of DSE for detecting moderate or severe stenosis was greater than mibi SPECT (97% v 74%; p = 0.007). Wall motion abnormalities with DSE and transient perfusion defects with mibi SPECT outside the infarction zone were sensitive (80% v 67%; NS) and highly specific (95% v 93%; NS) for multivessel disease. CONCLUSIONS: DSE and mibi SPECT have equivalent accuracy for detecting residual infarct related artery stenosis of >/= 50% and multivessel disease early after acute myocardial infarction. DSE is more predictive of moderate or severe infarct related artery stenosis. Combined imaging only improves the detection of mild stenosis.  (+info)

Value of fractional flow reserve in making decisions about bypass surgery for equivocal left main coronary artery disease. (7/1816)

OBJECTIVE: To investigate the value of coronary pressure derived fractional flow reserve (FFR) measurements in supporting decisions about medical or surgical treatment in patients with angiographically equivocal left main coronary artery stenosis. DESIGN: A two centre prospective single cohort follow up study. INTERVENTIONS: FFR of the left main coronary artery was determined in 54 consecutive patients with angiographically equivocal left main coronary artery disease. If FFR was >/= 0.75, medical treatment was chosen; if FFR was < 0.75, surgical treatment was chosen. MAIN OUTCOME MEASURES: Freedom from death, myocardial infarction, or any coronary revascularisation procedure. RESULTS: In 24 patients (44%), FFR was >/= 0.75 and medical treatment was chosen (medical group). In the remaining 30 patients (56%), FFR was < 0.75 and bypass surgery was performed (surgical group). Mean (SD) follow up was 29 (15) months (range 12-65 months). Survival among patients at three years of follow up was 100% in the medical group and 97% in the surgical group. Event-free survival was 76% in the medical group and 83% in the surgical group. CONCLUSIONS: FFR supports decision making in equivocal left main coronary artery disease. If FFR is below 0.75, the decision for bypass surgery is supported. If FFR is above 0.75, a conservative approach is justified.  (+info)

Coronary thermodilution to assess flow reserve: experimental validation. (8/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are indices of coronary stenosis severity that provide the clinician with complementary information on the contribution of epicardial arteries and microcirculation to total resistance to myocardial blood flow. At present, FFR and CFR can only be obtained by 2 separate guidewires. The present study tested the validity of the thermodilution principle in assessing CFR with one pressure-temperature sensor-tipped guidewire. METHODS AND RESULTS: In an in vitro model, absolute flow was compared with the inverse mean transit time (1/T(mn)) of a thermodilution curve obtained after a bolus injection of 3 mL of saline at room temperature. A very close correlation (r>0.95) was found between absolute flow and 1/T(mn) when the sensor was placed >/=6 cm from the injection site. In 6 chronically instrumented dogs (60 stenoses; FFR from 0.19 to 0.98), a significant linear relation was found between flow velocity and 1/T(mn). A significant correlation was found between CFR(Doppler), which was calculated from the ratio of hyperemic to resting flow velocities, and CFR(thermo), which was calculated from the ratio of resting to hyperemic T(mn) (r=0.76; SEE=0.24; P<0.001). CONCLUSION: The present findings demonstrate the validity of the thermodilution principle to assess CFR. Because the pressure-temperature sensor was mounted in a commercially available angioplasty guidewire, this technique permits simultaneous measurements of CFR and FFR.  (+info)

*The Lancet

Transluminal dilatation of coronary-artery stenosis; A. R. Gruentzig - erster Bericht über eine Koronardilatation PMID 74678 ...

*Dextro-Transposition of the great arteries

If d-TGA is accompanied by both a VSD and pulmonary stenosis, a systolic murmur will be present. On the rare occasion (when ... This is a less common variant, and with this arrangement, an unusual coronary artery pattern is common. There are also some ... It has as contra-indication coronary anomalies. Since 1981 Lecompte has put his Lecompte manoeuvre in use. This is used with ... The procedure involves transecting both the aorta and pulmonary artery; the coronary arteries are then detached from the aorta ...

*Derek Enlander

Review." " Thallium-201 scintigraphy in diagnosis of coronary stenosis. Comparison with electrocardiography and coronary ...

*Movat's stain

... showing luminal stenosis in coronary artery atherosclerosis. "Pathology News: Newsletter, Vol. 3, No. 4: April ...

*Shepherd's crook

"Percutaneous transluminal angioplasty for shepherd's crook right coronary artery stenosis". Catheterization and Cardiovascular ... In medicine, the term shepherd's crook is used to describe a right coronary artery that follows an unusually high and winding ... and Classifying Congenital Anomalies of the Coronary Arteries". RadioGraphics. 32 (2): 453-468. doi:10.1148/rg.322115097. ISSN ...

*Takayasu's arteritis

This may develop into stenosis and occlusion. The characteristic finding is the presence of "skip lesions," where stenosis or ... A rare complication of this condition are coronary artery aneurysms. Although the cause of Takayasu arteritis is unknown, the ... Of note is the function of renal artery stenosis in the causation of high blood pressure: Normally perfused kidneys produce a ... Stenosis of the renal arteries causes hypoperfusion (decreased blood flow) of the juxtaglomerular apparatus, resulting in ...

*Coarctation of the aorta

Aortic coarctation and aortic stenosis are both forms of aortic narrowing. In terms of word root meanings, the names are not ... This can be fixed by either another coarctectomy[citation needed]. Coronary artery disease (CAD) is a major issue for patients ... Some children born with coarctation of the aorta have other heart defects too, such as aortic stenosis, ventricular septal ... After a coarctation repair 20-60% of infant patients may experience reoccurring stenosis at the site of the original operation ...

*Ostial disease

... , namely coronary ostial stenosis, is the occlusion of coronary ostium. Causing factors include atherosclerosis, ... Angelini, P (2012). "Congenital Coronary Artery Ostial Disease". Tex Heart Inst J. 39: 55-9. PMC 3298900 . PMID 22412228. ...

*Long-term complications of standing

The authors also found that men with carotid stenosis or ischemic heart disease were at greater risk for the progression of ... atherosclerosis . Atherosclerosis can lead to coronary artery disease, carotid artery disease, peripheral artery disease, and ...

*Pulmonary edema

Recurrence of FPE is thought to be associated with hypertension[16] and may signify renal artery stenosis.[17] Prevention of ... Flash pulmonary edema: association with hypertension and recurrence despite coronary revascularization. Am Heart J. 2000 Sep; ... Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: treatment by angioplasty or surgical ... recurrence is based on managing hypertension, coronary artery disease, renovascular hypertension, and heart failure. ...

*Nicorandil

... coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple ... Overall, this leads to relaxation of the smooth muscle and coronary vasodilation. The effect of nicorandil as a vasodilator is ... Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic ... In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma ...

*R. Ravi Kumar

Patient had coronary artery disease and severe mitral valve leak. Patient had combined robotic mitral valve replacement and ... 23-year-old male who had chest discomfort,shortness of breath and palpitations for 4 years.Had mitral valve stenosis (shrunk) ... Patient had aortic valve stenosis (shrunk) and regurgitation (leak) with reduced pumping of the heart. He underwent robotic ... and regurgitation (leaking) and aortic valve stenosis (shrunk).Had robotic double valve replacement. World's first Robotic ...

*Fractional flow reserve

... is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, ... May 2007). "Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study". J ... June 1996). "Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses". N. Engl. J ... Fractional flow reserve is defined as the pressure after (distal to) a stenosis relative to the pressure before the stenosis. ...

*Implant (medicine)

They're used to treat bone fractures, osteoarthritis, scoliosis, spinal stenosis, and chronic pain. Examples include a wide ... and coronary stent. Orthopaedic implants help alleviate issues with the bones and joints of the body. ...

*U wave

"Exercise-induced U-wave inversion as a marker of stenosis of the left anterior descending coronary artery". Circulation. 60: ... The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... According to V. Gorshkov-Cantacuzene: "The U wave is the momentum carried by the blood in the coronary arteries and blood ... This idea is also proved by the fact that hypertrophy of the left ventricle, myocardial ischemia, coronary and insufficiency ...

*Oscar Werner Tiegs

He suffered from aortic stenosis, and died of a coronary occlusion in his home in Hawthorn, aged 59. Ocsar Tiegs' scientific ...

*Ventricular tachycardia

... can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems, or a ... Ventricular tachycardia can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems (e.g., ...

*Computer-aided simple triage

CAST system is available for the detection of significant (>50%) coronary stenosis in coronary CT angiography (cCTA) studies. ... Diagnosis of coronary stenosis with CT angiography: comparison of automated computer diagnosis with expert readings, Academic ... Automated computer-aided stenosis detection at coronary CT angiography: initial experience, European Radiology, 20(5):1160-7, ... of a Computer-Aided Simple Triage System for Coronary CT Angiography in Patients with Intermediate Risk for Acute Coronary ...

*Instantaneous wave-free ratio

Coronary artery blockages or stenoses that limit blood flow to the heart muscle can cause angina and can be treated by stenting ... Instantaneous wave-free ratio is performed using high fidelity pressure wires that are passed distal to the coronary stenosis. ... is a diagnostic tool used to assess whether a stenosis is causing a limitation of blood flow in coronary arteries with ... using invasive coronary pressure wires which are placed in the coronary arteries that are to be assessed. Pressure wires are ...

*Chest pain

If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Aortic stenosis - This condition happens when the patient has underlying congenital bicuspid valve, aortic sclerosis, or ... Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack") - People usually complained of a ... However, both atypical and typical symptoms of acute coronary syndrome can occur, and in general a history cannot be enough to ...

*Kawasaki disease

... and an aneurysm location in a distal coronary segment. The highest rate of progression to stenosis occurs among those who ... If the coronary arteries are involved, ongoing treatment or surgery may occasionally be required. Without treatment, coronary ... but the risk of coronary artery involvement is much greater. Overall, about 2% of patients die from complications of coronary ... In some children, coronary artery aneurysms may form in the heart after 1-2 years. The cause is unknown. It may be due to an ...

*Heart

These are the left main coronary artery and the right coronary artery. The left main coronary artery splits shortly after ... It can be influenced by narrowing of the heart valves (stenosis) or contraction or relaxation of the peripheral blood vessels. ... Two small openings above the aortic valve carry blood to the heart itself, the left main coronary artery and the right coronary ... A small amount of blood from the coronary circulation also drains into the right atrium via the coronary sinus, which is ...

*Wellens' syndrome

Coronary angiogram, with video on the left showing tight, critical (95%) stenosis of the proximal LAD in a patient who had ... coronary artery stenosis in patients with unstable angina. It is characterized by symmetrical, often deep (>2 mm), T wave ... "Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in ... Sensitivity and specificity for significant (more or equal to 70%) stenosis of the LAD artery was found to be 69% and 89%, ...

*Vasospasm

... referred to as percutaneous coronary intervention or angioplasty, involves placing a stent at the site of stenosis in an artery ... in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary ... Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. ... L-type calcium channel blockers can induce dilation of the coronary arteries while also decreasing the heart's demand for ...

*Outline of cardiology

Fractional flow reserve (FFRmyo): Testing the blood flow through a stenosis of a coronary artery to determine the perfusion of ... Coronary artery disease (CAD)- Coronary artery disease is a general term for any reduction in coronary circulation. One such ... Aortic stenosis - Narrowing of the aortic valve opening that reduces blood flow through the valve. Stenosis commonly occurs ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ...

*MTOR inhibitors

Since then, rapamycin has also shown to be effective for preventing coronary artery re-stenosis and for the treatment of ... In 2003, the U.S. Food and Drug Administration approved sirolimus-eluting coronary stents, which are used in patients with ... "CYPHER™ Sirolimus-eluting Coronary Stent - P020026". Food and Drug Administration. Retrieved 25 September 2012. "Torisel". ... narrowing of coronary arteries, or so-called atherosclerosis. Recently rapamycin has shown effective in the inhibition of ...

*Elastina - Wikipédia, a enciclopédia livre

2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ... and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis ...

*Mitral valve repair

The patient was a 12-year-old girl with rheumatic mitral stenosis. The development of the heart-lung machine in the 1950s paved ... Mitral regurgitation may also occur as a result of ischemic heart disease (coronary artery disease) or non-ischemic heart ... Mitral valve repair is a cardiac surgery procedure performed by cardiac surgeons to treat stenosis (narrowing) or regurgitation ...
In the United States, ULMCA PCI is performed primarily in patients with a high burden of comorbidities and frequently in those with high-urgency clinical presentations. In this population, in-hospital mortality was substantially higher in those with ULMCA disease who were treated percutaneously; however, this early risk is driven by those with high-urgency, rather than lower-urgency, presentations.. Among ULMCA patients selected for PCI in the United States, 30-month mortality is high (42.7%), with a predominance of cardiovascular events. These findings are especially notable when compared to the 10% mortality reported at 30 months in the MAIN-COMPARE (Korean Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) study (11), and the 4% mortality reported at 1 year in the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) trial (12). The increased patient age, burden of comorbidities, and ...
The long-term safety and efficacy of drug-eluting stent (DES) implantation in the treatment of unprotected left main coronary artery (LMCA) stenosis is still a matter of debate. All consecutive patients (pts) who had sirolimus (SES, Cypher, Cordis, Johnson and Johnson Company, Warren, NJ) or paclitaxel-eluting stent (PES, Taxus, Boston Scientific, Natick, MA) electively implanted in de novo lesions on LMCA between March 2002 and July 2006 were analyzed. A total of 267 patients were treated: 107 with PES and 160 with SES. Sixty-four (23.4%) patients were diabetics, 95 (35.6%) had unstable angina, mean age was 64.5±11.6 years and LVEF 52.2±10.7 %. High mortality risk scores (Euroscore ,6) were present in 84 (31.5%) of the patients. Glycoprotein IIb/IIIa inhibitors were used in 50 (18.7%) patients, 80 (29.9%) underwent intravascular ultrasound. Distal left main lesions were present in 223 (83.5%) of the patients: 209 bifurcations and 14 trifurcations. Both branches were stented in 108 (48.4%) ...
TY - JOUR. T1 - Current management of unprotected left main coronary artery disease. T2 - Run-in survey of the RITMO (Registro Italiano sul Trattamento del tronco coMune non protettO) study. AU - Sheiban, Imad. AU - Sillano, Dario. AU - Biondi-Zoccai, Giuseppe G L. AU - De Servi, Stefano. AU - Tamburino, Corrado. AU - Marzocchi, Antonio. AU - Trevi, Gian Paolo. AU - Moretti, Claudio. PY - 2009/9. Y1 - 2009/9. N2 - The optimal approach for a significant unprotected left main coronary stenosis (ULM) is debated, in light of the recent progresses of percutaneous coronary intervention (PCI). However, coronary artery bypass grafting (CABG) is still considered the first choice treatment. Randomized trials comparing PCI and CABG are ongoing, yet patient selection will considerably limit their clinical applicability. We thus designed a prospective multicenter registry which will include patients with ULM disease independently from the subsequent medical, interventional or surgical treatment: the RITMO ...
Allograft vasculopathy is the leading cause of death and morbidity after the first year of transplantation. Its prevalence is high: 11%, 22%, and 45% at one, two, and four years after transplantation, respectively.13,14 The accelerated coronary artery disease involves both the epicardial and the intramyocardial arteries. Its diagnosis is difficult because of the absence of angina in the denervated heart and the low sensitivity of non-invasive stress testing.15 The first manifestation of allograft vasculopathy is often congestive heart failure, ventricular arrhythmias, or sudden death.16 The ineffective medical treatment and the limited suitability of CABG and retransplantation have motivated interest in PCI for the subset of heart transplant recipients presenting with allograft vasculopathy in proximal segments. Schnetzler and colleagues17 reported 94.3% primary success (, 50% residual stenosis) in 53 lesions. Two of these patients had symptomatic left main stenosis, which were dilated with ...
Definition of Left main coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Left main coronary artery? Meaning of Left main coronary artery as a legal term. What does Left main coronary artery mean in law?
All the papers appraised note an association between this pattern and severe stenosis of the LMCA or 3-vessel disease. However, the evidence identified from nine cohort studies consistently shows that lone ST elevation in lead aVR has little diagnostic value for identifying patients with stenosis of the LMCA. Both sensitivity and specificity are suboptimal to guide clinical decision making. The evidence suggests that diagnostic performance may improve when there is accompanying diffuse ST depression. Kosuge et al 8 found that such changes have a specificity of 93% for LMCA stenosis or 3-vessel disease, although the positive predictive value in that sample was only 58%, which limits the value of the finding for ruling in LMCA stenosis. As such, taken alone this finding could not be used to guide the need for primary percutaneous coronary intervention, for example. However, as patients with LMCA stenosis are at particularly high risk, ST elevation in aVR may help to identify patients for early ...
Background and Purpose: Acute myocardial infarction(AMI) occurs in 1-2% of patients treated with carotid artery stenting(CAS), and is considered as one of the most serious perioperative complication. We assessed coronary artery stenosis in patients treated with CAS using coronary CTA or coronary angiography.. Methods: Consecutive sixty-two patients (47 men, mean age 73.4 years) treated with CAS were examined by coronary CTA or angiography within 3 months before CAS between January 2010 and August 2012. In patients suspected coronary artery stenosis by coronary CTA, coronary angiography was performed. Significantly coronary artery stenosis was defined as that greater than 75%.. Results: CAS was performed in 62 patients, and coronary artery was evaluated in 57 patients. Patients with allergic reaction for contrast agents, renal failure, and poor general condition were excluded from this study. Thirty-eight patients had significant coronary artery stenosis. Twenty-nine of them had any history of ...
Catheter intervention treatment is now widely accepted as a nonsurgical revascularization option for adult patients with coronary artery disease. However, the experiences in KD have been limited.7,10,11 In contrast to the success of PTCA for treatment of atheromatous coronary artery disease in the adult, it was reported10,11 that PTCA is not as effective in the dilatation of the severely calcified stenotic lesions in patients with KD via balloon angioplasty. In this study, we introduced the new device of PTCRA, which was effective in ablating stenotic vessel lesions with hard calcification in the children with coronary artery stenosis after KD. Although PTCA was effective in only one of our four patients, the other three required PTCRA to ablate the hardened stenotic coronary lesions.. The mechanism of coronary artery stenosis in KD is uncertain. One possibility is acute occlusion by massive thrombus formation in the coronary aneurysms, which occur mostly in acute or subacute stages of illness. ...
The use of percutaneous coronary intervention (PCI) for unprotected left main coronary artery stenosis is increasing but it remains unclear whether this approach is non-inferior to coronary artery bypass grafting (CABG). Both the Nordic-Baltic-British left main revascularisation study (NOBLE, n=1201) and Evaluation of an everolimus eluting stent versus coronary artery bypass surgery for effectiveness of left main revascularisation study (EXCEL, n=1905) randomised patients with severe left main coronary artery stenosis to PCI or CABG to address this question. Though similar, there are important differences in these studies design and results. Primary outcomes were defined as all cause death, stroke and non-procedural myocardial infarction (MI) in both trials with the addition of repeat revascularisation in NOBLE and post-procedural MI in EXCEL. Other study differences include intended duration of follow-up, non-inferiority margins, allowable coronary complexity, and stent type. The prevalence of ...
Video 297e-30 The bifurcation lesion in the left main coronary artery extending into the LCx and LAD ostia is treated using a "culotte" technique. First, a drug-eluting stent is placed in the left main coronary artery and into the proximal LCx. ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Abstract. Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). This has lead to the development of several algorithms for automatic detection and grading of coronary stenoses. However, most of these methods focus on detecting calcified plaques only. A few methods that can also detect and grade non-calcified plaques require substantial user involvement. In this paper, we propose a fast and fully automatic system that is capable of detecting, grading and classifying coronary stenoses in CCTA caused by all types of plaques. We propose a four-step approach including a learning-based centerline verification step and a lumen crosssection estimation step using random regression forests. We show state-of-the-art performance of our method in experiments conducted on a set of 229 CCTA
Then we fast forward till September 15th 1977, when Dr A Greuntzig successfully dilated an LAD stenosis in a Swiss dentist. This further proved that the goal post has moved again. That it was safe ( with all the appropriate training and precautions ) to safely work within coronary arteries. This began the journey of "percutaneous coronary interventions ". One by one, the goal post moved. Initially, Dr Greuntzig only advocated angioplasty ( as the new procedure was initially called ) for single lesion CAD. Then with better equipment and devices we began to do two vessels and then three vessels disease, much to the chargrin of our cardiac surgeons. The goal post was moving and still is. Coronary interventionist, ably led by the Korean Dr SJ Park and the French, Dr Jean Marco and Fajadet, began to take on left main stem disease, initially in the protected left main ( left main disease with a good functioning bypass graft ), and later in unprotected left main stem disease ( isolated ) and gradually ...
Coronary artery disease had spread in a larger number among the people worldwide. According to statistics, about 50 percent of the patients suffered from left main coronary artery stenosis. Many of the people possess the risk of the heart failure due to blockage in vessels that mainly occurs at the left main coronary artery. This Read more ...
For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial perfusion imaging is feasible and accurate.
Among the bifurcation type, bifurcation lesion without significant side branch stenosis (,50%) usually did not require side branch stenting, but owing to several putative mechanism including dissection, thrombosis formation, embolization of plaque debris, ostial compromise by displaced stent strut, and snow plow effect, the side branch might be compromised. In this situation, the strategy to achieve optimal results has not been reported. Recently, FFR study showed that most jailed side branch (vessel size ,2.0 mm. DS,50%) after main branch stenting did not have functional significance. We compared strategies with or without routine kissing balloon dilatation for less than 50% stenosis after simple DES crossing for bifurcation lesions (bifurcation type 1.1.0, 1.0.0, and 0.1.0 according to Medina classification) with serial change of FFR measurement ...
... is that situation in which a coronary artery got lessened and backed up in the company of materials like cholesterol or fat. Coronary artery
Watch this LIVE case if you want to learn more about left main PCI, unprotected left main angioplasty strategy and distal LM bifurcation stenting.A 64-year-old male with distal LM bifurcation, LAD and LCX diseases:Two-stent techniquesIVUS assessment
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
In Reply: Dr Dewey and colleagues asked about discrimination of ischemia by FFRCT vs CT. Discrimination was determined by area under the receiver operating char
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Spheric, ovoid or irregular intraluminal filling defect or lucency surrounded on three sides by contrast medium seen just distal or within the coronary stenosis in multiple projections or a visible embolization of intraluminal material downstream ...
AUM Cardiovasculars CADence System for Coronary Artery Stenosis Testing http://www.medgadget.com/2015/01/aum-cardiovasculars-cadence-system-for-coronary-artery-stenosis-testing.html via @medgadget
The main purpose of this study is to observe the incidence of major adverse cardiac and cerebrovascular events (MACCE), target vessel failure (TVF), target vessel revascularization (TVR) and stent thrombosis out to 5 years after the procedure in patients who underwent percutaneous coronary intervention (PCI) with everolimus-eluting stents for unprotected left main coronary artery (ULMCA) disease and lesions involving the ULMCA in Japan. The investigators will also establish a method of adjustment to the Japanese version of the SYNTAX score by conducting an assessment using the SYNTAX score recently reported in the US and Europe as well as the EuroSCORE, and by clarifying the differences of PCI procedures and treatment results in Japan with those reported in the US and Europe ...
Fractional flow reserve (FFR) is a well-validated tool for determining the functional significance of a coronary artery stenosis, facilitating clinical decisions regarding the need for revascularization. FFR-guided revascularization improves clinical and economic outcomes. However, its application remains challenging in certain complex anatomic subsets, including left main coronary artery stenosis, bifurcation disease, and saphenous vein graft disease. This article reviews recent data supporting the use of FFR in these complex anatomic subsets. [Rev Cardiovasc Med.
TY - JOUR. T1 - Performance of computed tomography-derived fractional flow reserve using reduced-order modelling and static computed tomography stress myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis. AU - Ihdayhid, Abdul Rahman. AU - Sakaguchi, Takuya. AU - Linde, Jesper J.. AU - Sørgaard, Mathias H.. AU - Kofoed, Klaus F.. AU - Fujisawa, Yasuko. AU - Hislop-Jambrich, Jacqui. AU - Nerlekar, Nitesh. AU - Cameron, James D.. AU - Munnur, Ravi K.. AU - Crosset, Marcus. AU - Wong, Dennis T.L.. AU - Seneviratne, Sujith K.. AU - Ko, Brian S.. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Aims: To compare the diagnostic performance of a reduced-order computed tomography-derived fractional flow reserve (CT-FFR) technique derived from luminal deformation and static CT stress myocardial perfusion (CTP).Methods and results: Forty-six patients (84 vessels) with suspected coronary artery disease from a single institution planned for elective coronary angiography ...
Fractional flow reserve (FFR) is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine the likelihood that the stenosis impedes oxygen delivery to the heart muscle (myocardial ischemia). FFR is a novel and potentially clinically useful mathematical solution for estimation of stenotic coronary artery atherosclerosis. Reliability/collaborative measurement between capable laboratories in measuring this essential metric appears muddled in a proprietary race to claim cardiac mathematics dedicated to risk in ischemic cardiac disease. Proprietary claims of cardiac mathematics have not been previously argued in patent law. Fractional flow reserve is defined as the pressure after (distal to) a stenosis relative to the pressure before the stenosis. The result is an absolute number; an FFR of 0.80 means that a given stenosis causes a 20% drop in blood pressure. In other words, FFR expresses the ...
OBJECTIVE To compare the consistency of angiography-guided and fractional flow reserve (FFR)-guided management strategy for intermediate coronary lesions. METHODS The patients whose coronary intermediate lesions were assessed by measuring FFR from November 2012 to August 2014. The stenosis percentage and value of FFR during the procedure were collected. All the image data were collected and four experienced interventional cardiologists were invited to assess the target lesions and make a management strategy independently. The consistency of angiography-guided and fractional flow reserve-guided management strategy were analyzed. RESULTS In the study, 151 patients were included, of whom, 70.2% were male, the average age was (62.7±9.6) years, 169 vessels were assessed by measuring FFR, 1 being left main, 116 left anterior descending, 27 left circumflex branch, and 25 right coronary artery. There were some correlationship between the stenosis percentage judged by four interventional cardiologists and
TY - JOUR. T1 - The long-term clinical outcome of T-stenting and small protrusion technique for coronary bifurcation lesions. AU - Naganuma, Toru. AU - Latib, Azeem. AU - Basavarajaiah, Sandeep. AU - Chieffo, Alaide. AU - Figini, Filippo. AU - Carlino, Mauro. AU - Montorfano, Matteo. AU - Godino, Cosmo. AU - Ferrarello, Santo. AU - Hasegawa, Tasuku. AU - Kawaguchi, Masanori. AU - Nakamura, Sunao. AU - Colombo, Antonio. PY - 2013/6. Y1 - 2013/6. N2 - Objectives This study sought to report long-term clinical outcomes in patients treated with the provisional T-stenting and small protrusion (TAP) technique. Background Several strategies have been proposed for treating bifurcation lesions, each with its own merits and technical challenges. The TAP technique is a relatively new strategy that is technically less challenging, ensures complete coverage of the side-branch ostium, and minimizes stent overlap. Although there is reasonable amount of data for other bifurcation strategies, the long-term ...
Second generation drug-eluting stents are safe and effective in treatment of left main coronary artery disease. A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the worlds premier educational meeting specializing in interventional cardiovascular medicine.. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often considered at high-risk of adverse cardiovascular events. The use of first generation drug-eluting stents in these lesions has previously been shown to be feasible, safe, and effective. The second-generation zotarolimus-eluting (ZES) and everolimus-eluting stents (EES), used more widely in clinical practice at present, perform very similarly in ...
In the present study, we compared the prognostic impact of treatment strategy on clinical outcomes according to bifurcation lesion location (LM vs. non-LM bifurcation lesion) using data from a large, multicenter, dedicated bifurcation registry. The main findings of the present study are that compared with the 1-stent strategy, the 2-stent strategy was associated with higher risks of cardiovascular events in patients with LM bifurcation lesion, whereas this association was attenuated in those with non-LM bifurcation lesions, and that significant interactions were present between treatment strategy and bifurcation lesion location in the adjusted risks of target lesion failure, target lesion revascularization, and target vessel revascularization.. Coronary bifurcation lesions are complex, and their treatment continues to be the subject of substantial debate, even in the DES era (1,2). Previous randomized trials comparing the 1-stent strategy with the elective 2-stent strategy (mainly in patients ...
ST. PAUL, Minn.--(BUSINESS WIRE)--St. Jude Medical, Inc. (NYSE: STJ), a global medical device company, today announced its wireless PressureWire™ Aeris technology, which aids in the diagnosis and treatment of coronary artery blockages by measuring Fractional Flow Reserve (FFR), will now be available to hospitals using the Philips Xper Flex Cardio physiomonitoring system. Physicians will have greater access to the markets only wireless FFR measurement system through this new Philips agreement. FFR measurements indicate the severity of blood flow blockages in the coronary arteries, allowing physicians to better identify which specific lesion or lesions are responsible for a patients ischemia, a deficiency of blood supply to the heart caused by blood flow restriction. The PressureWire Aeris technology helps physicians determine the best treatment options for patients during coronary interventions, such as stent procedures. The PressureWire Aeris system offers a secure, wireless interface between ...
... : The Heart (Function, Facts (The heart pumps about 6 quarts (5.7 liters) of blood throughout the body, The heart beats about 100,000 times per day (about 3 billion beats in a lifetime), An adult heart beats about 60 to 80 times per minute, The heart weighs between about 10 to 12 ounces (280 to 340 grams) in men and 8 to 10 ounces (230 to 280 grams) in women, Newborns hearts beat faster than adult hearts, about 70 to 190 beats per minute, A human heart is roughly the size of a large fist, The heart is located in the center of the chest, usually pointing slightly left ), Anatomy (Two lower chambers (the ventricles), The right atrium and right ventricle together make up the right heart, Two upper chambers (the atria), The left atrium and left ventricle make up the left heart, The physiology of the heart comes down to structure, electricity and plumbing , A double-walled sac called the pericardium encases the heart, which serves
To the best of our knowledge, this is the only prospective, randomized study with long-term results at 7 years in patients with isolated lesions of the proximal LAD treated by either PCI with SES or MIDCAB surgery. There were no significant differences in the composite primary endpoint and individual "hard" endpoints such as cardiac death and myocardial infarction between PCI with SES and MIDCAB. However, TVR was more frequent with PCI.. Current guidelines for revascularization of stable coronary artery disease recommend a stop of the procedure and discussion of further therapy with the patient and the heart team, after the discovery of an isolated proximal LAD stenosis. In American guidelines, revascularization in patients with single-vessel disease and an isolated proximal LAD stenosis PCI has a Class IIb Level of Evidence: B recommendation and surgery with left internal mammary artery a Class IIa B recommendation, whereas in European guidelines PCI has a Class IIa Level of Evidence: B ...
AbeBooks.com: Physiological Assessment of Coronary Stenoses and the Microcirculation (9781447152446) and a great selection of similar New, Used and Collectible Books available now at great prices.
Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosis Journal Article published 17 Sep 2013 in Journal of International Medical Research volume 41 issue 5 on pages 1520 to 1531 Authors: Dan-Dan Dong, Kai Wang, Dan Wang, Tong Zhang, Ying-Feng Tu, Bao-Zhong Shen. ...
BACKGROUND: The value of angiographic follow-up in unprotected left main (ULM) stenting remains undefined. METHODS: The FAILS-2 registry included consecutive patients presenting with a critical lesion of an ULM treated with second generation drug eluting stents in 6 centers from June 2007 to January 2015. Patients were stratified into two groups: those discharged with planned angiographic follow-up and those with clinical follow-up. MACE (Major Adverse Clinical Events, a composite end point of death, myocardial infarction, TLR, and ST) was the primary end point, while each component was a secondary endpoint Sensitivity analysis was performed for patients treated with a provisional or a two-stent strategy ...
BACKGROUND: Postoperative myocardial injury (PMI) is a strong predictor of mortality after noncardiac surgery. PMI is believed to be attributable to coronary artery disease (CAD), yet its etiology is largely unclear. We aimed to quantify the prevalence of significant CAD in patients with and without PMI using coronary computed tomography angiography (CCTA). METHODS: This prospective cohort study included patients of 60 years or older without a history of cardiac disease and with and without PMI after intermediate- to high-risk noncardiac surgery. PMI was defined as any serum troponin I level ≥60 ng/L on the first 3 postoperative days. Main exclusion criteria were known cardiac disease and postoperative ischemic symptoms or electrocardiography abnormalities. Noninvasive imaging consisted of a postoperative CCTA. Main outcome was CAD defined as >50% coronary stenosis on CCTA. RESULTS: The analysis included 66 patients. Median peak troponin levels in the PMI (n = 46) and control group (n = 20) ...
A method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed. In one embodiment, medical image data of the patient including the stenosis
Coronary CT angiography (CCTA) identified plaques in acute MI patients whose coronary angiograms did not produce evidence of significant coronary stenosis.
If we think we have unraveled all the mysteries of human coronary blood flow we are sadly mistaken . Most cardiac physicians spend their prime life in opening the obstructed coronary arteries playing a role of coronary plumber. Like any plumber , it is not going to be one time job and our patients …
A new study clarifies that statins are the greatest medical fraud of all time. The claims made for them are false. The amount of harm they do is staggering, resulting in millions of lives devastated and ended. The worst part of all, though, is that it was entirely predictable-but studies were designed to hide the truth. The media, the health agencies, and the doctors all provided cover for Big Pharma. After all, there was money to be made.. ...
Left main ostial lesion remains a challenging task .A new stent design is proposed here. The lesion The hardware The technique Final message This thought came when I recently encountered a patient with a left main ostial stent which was projecting well into aortic root .It is an open access patency ,whoever is capable of…
I was wondering if anyone knows why FFR (Fractional flow reserve) isnt used in all cath labs? I read about a good example last year where a man was having a heart attack. In the Cath lab they used FFR...
We prospectively analyzed all consecutive patients treated at our center for bifurcation lesions from 2011-2015 and compared the angiographic and clinical outcomes of patients with left main bifurcation lesions vs those with non-left main bifurcation ...
I think he is saying NT or angi or something. I cannot tell. This is in the area of her abdomen and she is being seen for not having bowel movements for two days ...
If serial stenoses are less than 3 vessel reference diameters apart, they should be scored as one lesion. However, stenoses at a greater distance from each other (more than 3 vessel reference diameters), are considered as separate lesions ...
ACIST Medical Systems - US - Advancing diagnostic assessments with Rapid FFR The ACIST RXi® system combines accurate and reliable FFR measurements with the advantages of Rapid Exchange technology.
TY - JOUR. T1 - Coronary stenosis severity assessed by 256-slice MDCT angiography in comparison with stress myocardial perfusion imaging. AU - Yonezawa, Masato. AU - Higuchi, K.. AU - Yamazaki, Y.. AU - Jinnouchi, M.. AU - Maruoka, Y.. AU - Isoda, T.. AU - Kamitani, T.. AU - Baba, S.. AU - Matsuo, Y.. AU - Abe, K.. AU - Honda, H.. PY - 2012/1/10. Y1 - 2012/1/10. N2 - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the diagnostic accuracy of MDCT for detecting myocardial ischemia by 201Tl SPECT. Fifty-three patients underwent both coronary CT angiography and stress myocardial perfusion SPECT. All coronary arteries were assessable with appropriate image quality. MDCT revealed high specificity, but only half of stenotic lesion by MDCT revealed ischemia on SPECT.. AB - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the ...
Accurate functional diagnosis of coronary stenosis is vital for decision making in coronary revascularization. With recent advances in computational fluid dynamics (CFD), fractional flow reserve (FFR) can be derived non-invasively from coronary computed tomography angiography images (FFRCT) for functional measurement of stenosis. However, the accuracy of FFRCT is limited due to the approximate modeling approach of maximal hyperemia conditions. To overcome this problem, a new CFD based non-invasive method is proposed. Instead of modeling maximal hyperemia condition, a series of boundary conditions are specified and those simulated results are combined to provide a pressure-flow curve for a stenosis. Then, functional diagnosis of stenosis is assessed based on parameters derived from the obtained pressure-flow curve. The proposed method is applied to both idealized and patient-specific models, and validated with invasive FFR in six patients. Results show that additional hemodynamic information about the
Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. Indications Class I indications for CABG from the American College of Cardiology (ACC) and the American Heart Association (AHA) are as follows: Left main coronary artery stenosis...
Dislodgement and embolization of the new generation of coronary stents before their deployment are rare but could constitute a very serious complication. We report a case of a stent dislodgement into the left main coronary artery during the pri
Pre-operative assessment of coronary artery disease with conventional coronary angiography has been recommended in the guidelines of the American College of Cardiology/American Heart Association for selected patients scheduled for cardiac valve surgery (15). Recently introduced multislice CT allows noninvasive coronary artery imaging and has been shown to reliably exclude significant coronary artery stenosis (8,9). The major advantage of multislice CT over conventional coronary angiography in patients with acute IE is its noninvasiveness and thus avoidance of the high embolization risk of valvular vegetations during catheter manipulation. Once spread into the systemic arterial circulation, those vegetations can cause severe complications such as cerebral or peripheral embolization (17).. In this study, multislice CT showed an excellent diagnostic performance in assessing morphologic abnormalities commonly seen in patients with IE. Accuracy of vegetation, abscess, and pseudoaneurysm detection ...
Chest pain is the most common reason for invasive cardiac diagnostic. However, in less than half of the patients intended to elective coronary angiography significant obstructive CAD is confirmed. Therefore, recurrent episodes of angina and inducible ischemia in subjects without obstructive CAD are common clinical findings - the syndrome called non-obstructive CAD (NobCAD). Most often such patients are neither further investigated nor offered specific treatment. However the absence of significant coronary stenoses on angiography does not necessarily imply a healthy coronary tree. In such cases, myocardial ischemia may result from different types of functional disease involving the epicardial coronary arteries, coronary microcirculation, or both. Endothelial dysfunction is hypothezised as pathophysiological reason. Recently, the basic principles of diagnostic tests in the setting of suspected NobCAD have been discussed and a diagnostic sequence of reasonable practical implementation was ...
Choice of coronary artery stenosis,1 what is a coronary artery?Coronary artery is the artery supplying blood to the heart. As a result of coronary heart disease caused by cor
Latest studies confirm that measuring Fractional Flow Reserve (FFR) to guide the placement of stents leads to better outcomes for patients! In January 2012 a major trial called FAME II was stopped after only two-thirds of patients were enrolled.
The recent Article by Timo Mäkikallio and colleagues (Dec 3, p 2743)1 reported the eagerly awaited 5-year results of the NOBLE trial, comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) for the treatment of unprotected left main stem stenosis. The authors concluded that CABG might be preferred to PCI, because of the lower risk of non-procedural myocardial infarction and repeat revascularisation, despite a higher rate of reoperation within 30 days and similar mortality between the two groups.. ...
MIAMI -- The unprotected left main coronary artery is challenging to stent, but two second-generation drug-eluting stents have proved safe and effective, according to a randomized trial.
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Rentrop et al. researched collateral filling of stenotic coronary artery during inflation of the PTA balloon. Contrast dye was injected as soon as the patient developed ST-T changes on ECG or angina, but no later than 90 seconds after inflation of the balloon.
The Fractional Flow Reserve (FFR) in the LAD was grossly abnormal, 0.37. The pressure-flow index of stenosis severity, the Hyperaemic Stenosis Resistance (hSR=aortic pressure - distal pressure/mean peak velocity), was also measured. hSR values in excess of 0.80 mmHg-1 cm-1 s have been shown to correlate with ischaemia on non-invasive testing.1 This was 2.91 mmHg-1 cm-1 s in the LAD, concordant with the FFR result. Microvascular resistance (hMR) was also calculated, (distal coronary pressure/mean peak velocity). hMR is thought to be independent of epicardial coronary disease and values in excess of 2.0 mmHg cm s-2 are considered abnormal, although there is significant heterogeneity even in individuals with similar clinical characteristics. In the LAD territory hMR was elevated at 2.3 mmHg cm s-2 (Fig 3a ...
The BioNIR study aims to show that the BioNIR ridaforolimus eluting stent is non-inferior to the Resolute zotarolimus-eluting stent for the primary clinical
Coronary x-ray computed tomography angiography (CCTA) continues to develop as a non-invasive method for the assessment of coronary vessel geometry and the ident...
March 19, 2014 -- San Diego -- Volcano Corporation (NASDAQ: VOLC) a leading developer and manufacturer of precision guided therapy tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, today announced FDA clearance of its proprietary instant wave-Free Ratio or iFR Modality.. The iFR Modality is a physiologic measurement performed using the same pressure wires and equipment utilized in cath labs for Fractional Flow Reserve (FFR), but avoids injection of hyperemic agents into the patient that induce stress to the heart. This allows for a meaningful, lesion-specific assessment in seconds by amplifying the resting pressure waveform. The iFR Modality is currently installed on more than 300 systems around the world, primarily in Europe and Japan. FDA Clearance now means that more than 90% of Volcanos worldwide installed base of multi-modality systems can be upgraded. "As cardiologists today we are concerned not only with the wellbeing of our patients, but ...
Paper Abnormal Left Ventricular Contractile Response to Exercise in the Absence of Obstructive Coronary Artery Disease Is Associated with Resting Left Ventricular Long-Axis Dysfunction Presenter SP Summary Background The etiology of reduced left ventricular (LV) ejection fraction after exercise, without obstructive coronary artery disease or other established causes, is unclear. The aims of this study…
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Patient with stenosis in the proximal segment of LAD classified as ≥50% on CTCA related with large and reversible perfusion defects (ischemia) in apex, anteri
They are right: There are better tests to detect stenoses or blockages, such as stress tests, heart catheterization, and CT coronary angiography. If someone is having chest pain or breathlessness, these tests are useful to help understand why. These tests are preludes to stents, bypass surgery, and the like. They are the popular tools in hospitals, the ones that provide entry into the revenue-yielding world of heart disease procedures.. Plaque detection, on the other hand, is principally a tool for the person without symptoms. In this regard, it is more like cholesterol testing. I doubt my colleagues would bash cholesterol because it doesnt reveal blockages. Plaque detection identifies the person who has already started developing atherosclerosis.. Dr. William Blanchett of Colorado articulates this idea well:. EBT calcium imaging not only identifies the vast majority of individuals at risk, it also identifies individuals with minimal risk. In other words, it distinguishes those who are likely ...
The device] is placed onto a patients chest and a microphone picks up coronary sounds associated with stenosis, in which a patients arteries are clogged with plaque blocking blood flow to the heart ...
TY - JOUR. T1 - Noninvasive visualization of the left main coronary artery by cross sectional echocardiography. AU - Weyman, A. E.. AU - Feigenbaum, Harvey. AU - Dillon, J. C.. AU - Johnston, K. W.. AU - Eggleton, R. C.. PY - 1976. Y1 - 1976. N2 - Real time cross sectional echocardiographic studies of the left main coronary artery (LMCA) were performed in 15 normal patients, 15 patients with angiographically proven coronary artery disease but normal left main coronary segments, three patients with greater than 75% obstruction of the left main coronary artery, and one patient with a large aneurysm of the left main coronary artery. In normal subjects the LMCA evaginates from the inferolateral wall of the aorta. The artery appears as two dominant parallel linear echoes separated by a clear space representing the lumen of the vessel. The LMCA courses beneath the right ventricular outflow tract and can generally be followed to its expected point of bifurcation. Confirmation that this structure was in ...
To the best of our knowledge, this is the first reported case of percutaneous coronary intervention (PCI) on RCA ostial stenosis after re-do AVR. Coronary ostial stenosis after AVR is rare and occurs most often in the left main coronary artery, but the RCA can also be affected. An autopsy report revealed that thickened tissue in the aortic root and proximal coronary artery showed fibrosis and intimal thickening and no evidence of atherosclerosis on histological examination [1]. This phenomenon has been proposed to be due to turbulent flow around the prosthetic valve leading to obstruction of the coronary ostia. Fibrotic thickened tissue protrusion was also observed in our case, which was confirmed with homogeneous low echogenicity on IVUS.. Although the pathophysiological mechanism of coronary ostial stenosis after AVR is not well understood, various mechanisms could have mutually influenced this case according to previous studies. First, there could be micro-injury and local hyperplastic ...
The use of Coronary Artery Bypass Grafting (CABG) rather than Percutaneous Coronary Intervention (PCI) for the management of patients with triple vessel or left main coronary artery disease is associated with lower rates of major adverse cardiac or cerebrovascular events at 1 year. The conclusion is based on a trail (STNTAX trail) published in New England Journal of Medicine March 2009 edition.. The SYNTAX (Synergy between PCI with taxus and cardiac surgery) trail, conducted in United States and several countries in Europe, involved 1800 patients with previously untreated triple vessel disease or left main coronary artery disease. The patients were randomly assigned to undergo CABG or PCI and were monitored for the subsequent 12 month period for any major cardiac or cerebrovascular event. Death from any cause, stroke, myocardial infarction and repeat revascularization were considered as major adverse events. The research was sponsored by Boston Scientific, developer of the drug eluting taxus ...
TY - JOUR. T1 - Rapid disappearance of an endothelial ulceration in the left main coronary artery. AU - Bokhari, Ismail A H. AU - Bokhari, Ravia. AU - Alpert, Joseph S. PY - 2007/3. Y1 - 2007/3. N2 - A case is presented of a 65-year-old male who presented with an acute anterior wall myocardial infarction. An initial coronary angiogram demonstrated an ulcerated atherosclerotic plaque in the left main coronary artery. After 48 h of aggressive medical therapy including a 2b3a glycoprotein blocking agent, repeat angiography demonstrated resolution of the ulcerated plaque. The process of atherosclerotic plaque rupture is of dynamic nature.. AB - A case is presented of a 65-year-old male who presented with an acute anterior wall myocardial infarction. An initial coronary angiogram demonstrated an ulcerated atherosclerotic plaque in the left main coronary artery. After 48 h of aggressive medical therapy including a 2b3a glycoprotein blocking agent, repeat angiography demonstrated resolution of the ...
AIMS: To evaluate the diagnostic power of integrating the results of computed tomography angiography (CTA) and CT myocardial perfusion (CTP) to identify coronary artery disease (CAD) defined as a flow limiting coronary artery stenosis causing a perfusion defect by single photon emission computed tomography (SPECT). METHODS AND RESULTS: We conducted a multicentre study to evaluate the accuracy of integrated CTA-CTP for the identification of patients with flow-limiting CAD defined by ≥50% stenosis by invasive coronary angiography (ICA) with a corresponding perfusion deficit on stress single photon emission computed tomography (SPECT/MPI). Sixteen centres enroled 381 patients who underwent combined CTA-CTP and SPECT/MPI prior to conventional coronary angiography. All four image modalities were analysed in blinded independent core laboratories. The prevalence of obstructive CAD defined by combined ICA-SPECT/MPI and ICA alone was 38 and 59%, respectively. The patient-based diagnostic accuracy ...
Left main coronary artery (LMCA) disease has been reported in up to 10% of all patients with coronary artery disease (CAD) and in the majority of cases are associated with severe three-vessel CAD. Among patients with chronic coronary syndrome revascularization of significant LMCA disease improves prognosis, while there is a debate about which revascularization strategy, CABG surgery or percutaneous coronary interventions to use. We do a review of the available evidence about the impact of LMCA lesions on patient prognosis according to CAD extension and clinical presentation, the outcome after percutaneous or surgical revascularization, the procedural challenges of LMCA PCI and the available armamentarium to optimally treat this relevant population.. ...
Objective: To evaluate the agreement between multislice CT (MSCT) and intravascular ultrasound (IVUS) to assess the in-stent lumen diameters and lumen areas of left main coronary artery (LMCA) stents. Design: Prospective, observational single centre study. Setting: A single tertiary referral centre. Patients: Consecutive patients with LMCA stenting excluding patients with atrial fibrillation and chronic renal failure. Interventions: MSCT and IVUS imaging at 9-12 months follow-up were performed for all patients. Main outcome measures: Agreement between MSCT and IVUS minimum luminal area (MLA) and minimum luminal diameter (MLD). A receiver operating characteristic (ROC) curve was plotted to find the MSCT cut-off point to diagnose binary restenosis equivalent to 6 mm2 by IVUS. Results: 52 patients were analysed. Passing-Bablok regression analysis obtained a β coefficient of 0.786 (0.586 to 1.071) for MLA and 1.250 (0.936 to 1.667) for MLD, ruling out proportional bias. The α coefficient was ...
Coronary Artery Stenosis is a common Cardiac problem leading to heart attack. Instead of Coronary Bypass Surgery, Balloon Angioplasty has become a popular treatment modalities. To keep the artery patent after angioplasty, physicians are increasingly using Mesh like metal devices called sten.
Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation to final rupture of the plaque. In this study, we investigated the potential pathophysiological and clinical relevance of novel cytokines secreted from various cells including adipocytes, endothelial cells, and inflammatory cells, in predicting coronary artery disease (CAD) in asymptomatic subjects with type 2 diabetes mellitus. We enrolled a total of 70 asymptomatic type 2 diabetic patients without a documented history of cardiovascular disease, and determined serum levels of chemerin, omentin-1, YKL-40, and sCD26. We performed coronary computed tomographic angiography (cCTA) in all subjects, and defined coronary artery stenosis ≥ 50 % as significant CAD in this study. Subjects were classified into two groups: patients with suspected coronary artery stenosis on cCTA (group I, n = 41) and patients without any evidence of stenosis on cCTA (group II, n = 29). Group I showed
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
Among patients with unprotected left main coronary artery disease undergoing elective revascularization, there was no difference in two of the three primary endpoints, angina status or duration on treadmill stress test, between the stent and CABG treated patients, but LVEF was slightly higher in the PCI group. However, the trial has numerous limitations, including three "primary" endpoints; standard clinical trial methodolgy entails using one primary endpoint. Additionally, there was no statistical adjustment for multiple endpoints. The rate of infection following CABG was extremely high (13% during the first month), compared with a reported rate of ~3% in recent CDC reports. The presenters did not provide information on why the rate was higher than historical data. Additionally, the rate of repeat revascularization during the first year in the surgical group was 15%, much higher than historical data of ~4%, particularly given the fact that 79% of patients in the trial were treated with LIMAs, ...
Based on the method described by Reiber et al. (20), we devised and validated a simplified approach for estimating linear vessel tapering and calculating luminal stenosis severity on CCTA. Our method showed strong correlation to IQCA; the Pearson r-coefficient of 0.82 is similar to that reported by Raff et al. (3) (r = 0.76) and higher than that reported by Leber et al. (12) (r = 0.54). In the latter study, quantification of CCTA stenosis was based on the luminal diameter ratio of the stenotic site to proximal "healthy" vessel (12). Our method may have achieved higher correlation with IQCA in part by accounting for reference points proximal and distal to the stenosis and by assessing strictly luminal stenosis rather than accounting for positive remodeling. That our quantitative correlation was nearly identical to Raff et al. (3) (p = 0.94) despite studying older patients (mean age of 66 vs. 59 years) with higher global coronary calcification (mean coronary calcium score of 752 vs. 326) ...
Hazy filling defect on coronary angiography: insights from optical coherence tomography Other Refereed Contribution to Refereed Journals ...
The editorial (1) commenting on the paper by Park et al. (2) in the January 2015 issue of iJACC addressed the discordance between measured % diameter stenosis of the coronary artery disease (CAD) lesion by computed tomography angiography (CTA) and the presence of ischemia by invasive fractional flow reserve (FFR) of ,0.8, and concordance with high-risk plaque characteristics by CTA (volume, low attenuation, and positive remodeling). The pathway was reviewed, from atherosclerosis leading to endothelial dysfunction and impaired vasodilation response to physiological and pharmacological stress (i.e., microvascular dysfunction [MVD]), which would add to the maximal flow limitation imposed by the stenosis, and therefore postulated as an explanation of the increased prevalence of ischemia by invasive FFR.. However, impaired vasodilation response to pharmacological stress with adenosine during invasive FFR measurement results in a higher measured FFR value because a lower maximal flow rate is achieved, ...
TCT 2016 , Washington, DC - In lower surgical risk patients with left main coronary artery disease, stenting was on par with coronary artery graft surgery (CABG) in the EXCEL trial but not in the NOBLE trial, but many still saw the sum as a green light for percutaneous procedures. Read More ,,,. ...
Keywords: Three-dimensional (3D) CT angiography, Temsirolimus Digital subtraction angiography, Coronary luminal stenosis Background Atherosclerotic plaque leads to progressively increasing luminal stenosis, which could result in fatal cardiac events. Coronary angiography is currently the gold standard technique for assessment of coronary lumen stenosis Temsirolimus or occlusion [1C4]. However, it is an invasive procedure. A catheter should be used to insert into the coronary arteries for injecting dye, which would induce discomfort for the patient. Furthermore, it has limitations of differentiating plaque components [5]. Therefore, it is of paramount importance to evaluate the lumen stenosis using non-invasive imaging techniques. During the past decades, CT angiography (CTA) has become a rapidly developing non-invasive imaging technique, which showed promising application in the identification, visualization and characterization of the coronary artery stenosis [6, 7]. Sun et al. [8, 9] have ...
About Coronary Angiography Coronary Angiography, or Angiogram, is a minimally invasive procedure which is done to show the amount of coronary artery disease in the blood vessels that supply the heart. Coronary arteries can become clogged from a build-up of cholesterol, cells or other substances (plaque). This can reduce the flow of blood to your heart, causing chest pain,
ABSTRACT: Objectives. The purpose of this study was to evaluate the incidence of inaccurate stent positioning in the treatment of coronary aorto-ostial lesions. Background. The percutaneous treatment of aorto-ostial disease is challenging, with a paucity of data describing the incidence of stent mispositioning.
Dapatkan estimasi biaya untuk CT Coronary Angiogram di Cikarang pada pilihan rumah sakit dan dokter terbaik. Tim ahli medis kami siap memandu Anda memilih tindakan CT Coronary Angiogram yang paling tepat
Many people are affected by blocked heart blood vessels which remain one of the most common reasons for poor quality of life and death. Early detection of people who have blocked blood vessels of the heart can allow the use of proven treatments designed to reduce the progression of this problem. It has been shown in a number of studies that the early treatment of the process that causes these blockages can save lives. This is especially important in people who are at high risk of developing this disease and where current methods of screening are especially inadequate. We believe that our proposal will make a significant advancement in developing a screening tool that can reduce the number of people suffering from the consequences of this disease ...
Coronary angiography is a specialized X-ray test which gives perfect insight in the structure and functioning of the coronary arteries.
Title: Intracoronary Vascular Ultrasound (IVUS), Fractional Flow Reserve (FFR), Optical Coherence Tomography (OCT), Infraredex Speaker: Mazen Abu-
My mother has small pain in below chest and back of chest, then doctor advise to go for an angiogram, Angiogram shows Findings: 1.left main: normal 2.LAD:type-III lad. proximal to mid lad shows long...
بیستمین کنگره بین المللی تازه های قلب و عروق 20-23 شهریور ماه 97 _ سالن همایش بین المللی برج میلاد ...
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TY - JOUR. T1 - Algorithm to predict triple-vessel/left main coronary artery disease in patients without myocardial infarction. T2 - An international cross validation. AU - Detrano, Robert. AU - Jánosi, A.. AU - Steinbrunn, Walter. AU - Pfisterer, Matthias. AU - Schmid, Johann Jakob. AU - Maggie Meyer, M.. AU - Guppy, Kern H.. AU - Abi-Mansour, Pierre. PY - 1991. Y1 - 1991. N2 - Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. These data were obtained from a total of 1,074 such subjects from patient populations at four centers (Cleveland Clinic Foundation, Cleveland, Ohio; Hungarian Institute of Cardiology, Budapest, Hungary; the university hospitals, Zurich and Basel, Switzerland; and the Veterans Administration Medical Center, Long Beach, Calif.) and used to derive four separate ...
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was
TY - JOUR. T1 - Reimplantation of anomalous right coronary artery from left main coronary artery. T2 - A surgical option. AU - Karimi, Mohsen. AU - Murdison, Kenneth A. AU - Blackwood, Wesley. AU - Davis, Wesley. PY - 2010/4/1. Y1 - 2010/4/1. N2 - Anomalous right coronary artery (ARCA) from left sinus of Valsalva could present in several forms either being intramural or extramural, and most occurring with separate ostium from left coronary system. ARCA originating from the left main coronary artery (LMCA) is very rare and treatments proposed for this type of anomaly are pulmonary artery translocation or coronary artery bypass grafting (CABG) of the right coronary system. There has not been any report in the literature of successful reimplantation of ARCA from LMCA, to the best of our knowledge, as another surgical option for this anomaly. We are reporting a case of successful surgical reimplantation of an ARCA from LMCA.. AB - Anomalous right coronary artery (ARCA) from left sinus of Valsalva ...
We report an interesting case of a 66-year-old man with acute myocardial infarction (AMI) with bilateral coronary ostial stenosis cardiovascular syphilis complicated by aortic regurgitation (AR). A 12-lead electrocardiogram and blood tests on arrival suggested AMI, and echocardiography showed moderate AR. Emergency coronary angiography showed bilateral coronary ostial stenosis. The patient underwent emergency surgical treatment, coronary artery bypass grafting, and aortic valve replacement with a bioprosthetic valve. On arrival, rapid plasma reagin and Treponema pallidum hemagglutination tests were 172.2- and 1187.5-fold, respectively. These results suggested cardiovascular syphilis, which was confirmed by pathological findings. The postoperative course was uneventful and the patient was transferred to another hospital on postoperative day 25. This patient received intravenous penicillin for 2 weeks and subsequently oral amoxicillin. When both AR and coronary ostial stenosis are found, it is necessary
TY - JOUR. T1 - Internal pudendal artery stenoses and erectile dysfunction. T2 - Correlation with angiographic coronary artery disease. AU - Rogers, Jason H. AU - Karimi, Houshang. AU - Kao, John. AU - Link, Daniel P. AU - Javidan, Javid. AU - Yamasaki, Dwayne S.. AU - Dolan, Mark. AU - Laird, John R.. AU - Low, Reginald. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. Methods: Ten patients undergoing cardiac catheterization with ED and a history of unsatisfactory response to a PDE5i were studied. ED severity was quantified using the International Index of ED scoring system. We performed angiography ...
Table of Contents. Table of Contents 2. List of Tables 8. List of Figures 9. Introduction 10. Global Markets Direct Report Coverage 10. Coronary Artery Disease (CAD) (Ischemic Heart Disease) Overview 11. Therapeutics Development 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Overview 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Comparative Analysis 13. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Development by Companies 14. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Investigation by Universities/Institutes 17. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Pipeline Products Glance 18. Late Stage Products 18. Clinical Stage Products 19. Early Stage Products 20. Unknown Stage Products 21. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under Development by Companies 22. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under ...

Left main coronary artery stenosis. | CirculationLeft main coronary artery stenosis. | Circulation

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more infohttp://circ.ahajournals.org/content/59/1/192.1

Dynamic mechanisms in human coronary stenosis. | CirculationDynamic mechanisms in human coronary stenosis. | Circulation

Dynamic mechanisms in human coronary stenosis.. B G Brown, E L Bolson, H T Dodge ... At the clinical level, coronary stenoses frequently behave as though the obstruction to flow were variable and not as rigidly ... This extremely important morphologic feature of stenoses permits transient variation in stenosis lumen diameter in response to ... many of the clinical features of coronary disease and its pharmacologic responses are explained in terms of these stenosis ...
more infohttp://circ.ahajournals.org/content/70/6/917

Numerical Simulation and Clinical Implications of Stenosis in Coronary Blood FlowNumerical Simulation and Clinical Implications of Stenosis in Coronary Blood Flow

"Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional coronary ... O. F. Donati, P. Stolzmann, L. Desbiolles et al., "Coronary artery disease: which degree of coronary artery stenosis is ... with the same stenosis length of 4 mm. To investigate the effect of stenosis location, a 4 mm length stenosis with DS of 55% ... DS cannot characterize hemodynamic functional significance of coronary stenosis on myocardial blood supply. Among the stenoses ...
more infohttps://www.hindawi.com/journals/bmri/2014/514729/

Coronary artery stenosis Results from Everyday HealthCoronary artery stenosis Results from Everyday Health

coronary artery disorder coronary occlusion coronary artery disease coronary artery function entire coronary artery renal ... coronary arteries anatomy balloon angioplasty coronary angiography coronary artery distribution coronary artery bypass surgery ... Sex Makes No Difference in Coronary CT. diagnosing coronary artery disease in women thats... identify coronary stenosis ... coronary arteries be regarded as organs at risk in... lower odds of coronary artery stenosis for women... ...
more infohttps://www.everydayhealth.com/search/coronary-artery-stenosis/

Coronary graft stenosis Results from Everyday HealthCoronary graft stenosis Results from Everyday Health

coronary artery bypass graft coronary artery stenosis coronary artery disease vascular graft stenosis coronary occlusion artery ... coronary ostium stenosis percutaneous coronary intervention coronary arteriosclerosis cabg coronary graft occluded main disease ... identify coronary stenosis greater than 50 percent was... imaging to detect coronary stenosis in patients without... ... ANGELES - Coronary artery bypass grafting (CABG)... stenosis in two or more major coronary vessels (83 percent... ...
more infohttps://www.everydayhealth.com/search/coronary-graft-stenosis/

Diagnosis of functionally significant coronary stenosis with exercise CT myocardial perfusion imaging.  - PubMed - NCBIDiagnosis of functionally significant coronary stenosis with exercise CT myocardial perfusion imaging. - PubMed - NCBI

... with 55 coronary stenoses of at least 50% underwent coronary CT angiography (one stenosis in 13 patients, two stenoses in 15 ... 29 of 30 stenoses), 96% (23 of 24 stenoses), 97% (29 of 30 stenoses), 96% (23 of 24 stenoses), and 96% (52 of 54 stenoses), ... Diagnosis of functionally significant coronary stenosis with exercise CT myocardial perfusion imaging.. Habis M1, Ghostine S, ... in patients suspected of having hemodynamically significant coronary stenosis.. MATERIALS AND METHODS: This study had ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/25599157

Physiologic Assessment of Coronary Stenosis Following PCI - Full Text View - ClinicalTrials.govPhysiologic Assessment of Coronary Stenosis Following PCI - Full Text View - ClinicalTrials.gov

Coronary Artery Disease Coronary Stenosis Angina, Unstable Angina, Stable Diagnostic Test: iFR pullback ... Coronary Artery Disease. Angina Pectoris. Coronary Stenosis. Angina, Unstable. Angina, Stable. Constriction, Pathologic. ... Physiologic Assessment of Coronary Stenosis Following PCI (DEFINE PCI). The safety and scientific validity of this study is the ... Focal stenosis [ Time Frame: 12 month ]. Proportion of cases in which the iFR would become non-significant if a focal stenosis ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03084367

Noninvasive Physiologic Assessment of Coronary Stenoses Using Cardiac CTNoninvasive Physiologic Assessment of Coronary Stenoses Using Cardiac CT

... Lei Xu,1 Zhonghua Sun,2 and Zhanming Fan1 ... Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease ... CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the ... CCTA has emerged as a noninvasive method for the assessment of both anatomy of coronary lesions and its physiological ...
more infohttps://www.hindawi.com/journals/bmri/2015/435737/abs/

Single coronary artery with infundibular pulmonary stenosis. | HeartSingle coronary artery with infundibular pulmonary stenosis. | Heart

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more infohttps://heart.bmj.com/content/78/2/205

Elective stenting of carotid artery stenosis in patients with severe coronary artery disease.  - PubMed - NCBIElective stenting of carotid artery stenosis in patients with severe coronary artery disease. - PubMed - NCBI

Elective stenting of carotid artery stenosis in patients with severe coronary artery disease.. Waigand J1, Gross CM, Uhlich F, ... All patients had severe coronary artery disease, and/or mitral insufficiency, aortic stenosis, rhythm disorders or generalized ... In three patients the opposite carotid artery was occluded; nine patients had bilateral stenoses of which two received stents ... the feasibility and safety of elective carotid stent implantation in patients with carotid stenoses and concomitant coronary ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9792262?dopt=Abstract

Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging |...Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging |...

demonstrated in a small study that a very high coronary calcium score is a predictor of severe coronary stenosis in patients ... and right coronary artery (RCA). Severe left main coronary artery disease (LMCAD) was defined as ,50% diameter stenosis [9]. ... both with severe coronary stenosis.. Table 1 Comparison between severe and non-severe coronary artery disease, as assessed by ... Functional measurement of coronary stenosis. J Am Coll Cardiol. 2012;59:1045-57.CrossRefPubMedGoogle Scholar ...
more infohttps://link.springer.com/article/10.1007/s12471-018-1091-7

Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease - Full Text View - ClinicalTrials.govPreoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease - Full Text View - ClinicalTrials.gov

Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine ... Coronary Artery Disease. Myocardial Ischemia. Coronary Disease. Constriction, Pathologic. Aortic Valve Stenosis. Heart Diseases ... Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease. The safety and scientific validity of this study ... Genetics Home Reference related topics: Supravalvular aortic stenosis MedlinePlus related topics: CT Scans Coronary Artery ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00767013?recr=Open&cond=%22Aortic+Valve+Stenosis%22&rank=5

CiteSeerX - Detection, Grading and Classification of Coronary Stenoses in Computed Tomography AngiographyCiteSeerX - Detection, Grading and Classification of Coronary Stenoses in Computed Tomography Angiography

... grading and classifying coronary stenoses in CCTA caused by all types of plaques. We propose a four-step approach including a ... This has lead to the development of several algorithms for automatic detection and grading of coronary stenoses. However, most ... Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable ... alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). ...
more infohttp://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.228.5670

Aortocoronary bypass for critical stenosis of the left main coronary artery.Aortocoronary bypass for critical stenosis of the left main coronary artery.

... of the left main coronary artery underwent aortocoronary bypass. Intra-aortic balloon counterpulsation was used preoperatively ... Over a 2-year period 33 patients with symptomatic stenosis (greater than 75%) ... The authors conclude that aortocoronary bypass surgery for severe stenosis of the left main coronary artery can be safely ... Over a 2-year period 33 patients with symptomatic stenosis (greater than 75%) of the left main coronary artery underwent ...
more infohttp://www.biomedsearch.com/nih/Aortocoronary-bypass-critical-stenosis-left/312689.html

Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopyStent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy

... Han-Wei Wang, Ji-Xin Cheng, ... Han-Wei Wang, Ji-Xin Cheng, Michael Sturek, Vlad V. Simianu, Matthew J. Locker, "Stent-induced coronary artery stenosis ... Schematic of coronary stent deployment and sample collection. (a) Schematic drawing of coronary arteries and the study design ... For the analysis of the collagen expression in the stented coronaries, SFG images of the stented coronaries were quantitatively ...
more infohttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-16/issue-02/021110/Stent-induced-coronary-artery-stenosis-characterized-by-multimodal-nonlinear-optical/10.1117/1.3533313.full?SSO=1

Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease | SpringerLinkParaoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease | SpringerLink

... in coronary artery disease (CAD) is controversial. The aim of the present study was to evaluate whether the PON1... ... Paraoxonase Coronary artery disease Diabetes mellitus Genetic polymorphism Lipid profile Vessel stenosis ... Paraoxonase Arg 192 allele is an independent risk factor for three-vessel stenosis of coronary artery disease. ... Osei-Hyiaman D, Hou L, Mengbai F, Zhiyin R, Zhiming Z, Kano K (2001) Coronary artery disease risk in Chinese type 2 diabetics: ...
more infohttps://link.springer.com/article/10.1007%2Fs11033-011-0696-3

Coronary Stenosis Ongoing Global Clinical Trials Analysis and OutlookCoronary Stenosis Ongoing Global Clinical Trials Analysis and Outlook

Coronary Stenosis ongoing clinical trials report provides comprehensive analysis and trends in global Coronary Stenosis disease ... 3.1 Ongoing Coronary Stenosis Trials by Phase. 3.2 Ongoing Coronary Stenosis Trials by Type. 3.3 Ongoing Coronary Stenosis ... 7.1 Ongoing Coronary Stenosis Trials- Phase 1. 7.2 Ongoing Coronary Stenosis Trials- Phase 2. 7.3 Ongoing Coronary Stenosis ... Coronary Stenosis- Enrolment by Phase, 2018. Figure 8: Coronary Stenosis- Enrolment by Trial Type, 2018. Figure 9: Coronary ...
more infohttps://www.researchandmarkets.com/reports/4584678/coronary-stenosis-ongoing-global-clinical-trials

9781447152446: Physiological Assessment of Coronary Stenoses and the Microcirculation - AbeBooks: 14471524419781447152446: Physiological Assessment of Coronary Stenoses and the Microcirculation - AbeBooks: 1447152441

Physiological Assessment of Coronary Stenoses and the Microcirculation (9781447152446) and a great selection of similar New, ... 2. Physiological Assessment of Coronary Stenoses and the Microcirculation (Hardback) Published by Springer London Ltd, United ... 3. Physiological Assessment of Coronary Stenoses and the Microcirculation (Hardback) Published by Springer London Ltd, United ... 6. Physiological Assessment of Coronary Stenoses and the Microcirculation Published by Springer (2017) ...
more infohttps://www.abebooks.com/9781447152446/Physiological-Assessment-Coronary-Stenoses-Microcirculation-1447152441/plp

Precise Measurement of Coronary Stenosis Diameter with CCTA Using CT Number Calibration.Precise Measurement of Coronary Stenosis Diameter with CCTA Using CT Number Calibration.

... continues to develop as a non-invasive method for the assessment of coronary vessel geometry and the ident... ... Summary of "Precise Measurement of Coronary Stenosis Diameter with CCTA Using CT Number Calibration.". Coronary x-ray computed ... In patients with stable coronary artery disease, the amount of myocardium subtended by coronary stenoses constitutes a major ... Coronary Aneurysm. Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2506018/Precise-Measurement-of-Coronary-Stenosis-Diameter-with-CCTA-Using-CT-Number-Calibration.html

Coronary Flow Reserve and Intermediate Stenosis - American College of CardiologyCoronary Flow Reserve and Intermediate Stenosis - American College of Cardiology

Keywords: Angiography, Constriction, Pathologic, Coronary Artery Disease, Coronary Stenosis, Fractional Flow Reserve, ... Coronary Flow Reserve and Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis. J Am Coll Cardiol 2016; ... YOU ARE HERE: Home , Latest in Cardiology , Coronary Flow Reserve and Intermediate Stenosis ... What are the implications of coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) in patients with ...
more infohttps://www.acc.org/latest-in-cardiology/journal-scans/2016/04/06/16/30/coronary-flow-reserve-and-microcirculatory-resistance

Exercise Perfusion CT Imaging IDs Coronary Stenosis - MPRExercise Perfusion CT Imaging IDs Coronary Stenosis - MPR

For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial ... Participants, who had 55 coronary stenoses of at least 50%, underwent coronary CT angiography. Within one minute after ... Exercise Perfusion CT Imaging IDs Coronary Stenosis. This article originally appeared here. ... HealthDay News) - For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography ...
more infohttp://www.empr.com/medical-news/exercise-perfusion-ct-imaging-ids-coronary-stenosis/article/402916/

Should patients with stenosis of the left main coronary artery waiting for bypass grafting be given priority? | CMAJShould patients with stenosis of the left main coronary artery waiting for bypass grafting be given priority? | CMAJ

Is left main coronary artery stenosis a risk factor for early mortality in coronary artery surgery? J Card Surg 2000;15:217-22. ... Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary ... Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary ... Should patients with stenosis of the left main coronary artery waiting for bypass grafting be given priority?. Helena Rexius ...
more infohttps://www.cmaj.ca/content/173/4/381

Frequency of coronary artery stenosis in patients with asymptomatic fa | RRCCFrequency of coronary artery stenosis in patients with asymptomatic fa | RRCC

We aimed to determine the incidence of coronary artery stenosis (CAS) in asymptomatic FH patients using coronary computed ... Patients and methods: We enrolled consecutively, 31 FH patients without symptoms of coronary artery disease. Based on the CCTA ... Frequency of coronary artery stenosis in patients with asymptomatic familial hypercholesterolemia and its association with ... We aimed to determine the incidence of coronary artery stenosis (CAS) in asymptomatic FH patients using coronary computed ...
more infohttps://www.dovepress.com/frequency-of-coronary-artery-stenosis-in-patients-with-asymptomatic-fa-peer-reviewed-article-RRCC

Expansion characteristics of coronary stents in focal stenoses : Current Directions in Biomedical EngineeringExpansion characteristics of coronary stents in focal stenoses : Current Directions in Biomedical Engineering

The focal stenosis was simulated by a stainless steel tube (ID ≤ 1.20 mm). Stent expansion was performed using a proprietary ... None of the stent systems failed under the extremely high stress at the edges of the focal stenosis. ... experimental in vitro approach was designed to assess the expansion behavior of stent systems in a resistant focal stenosis ... Expansion characteristics of coronary stents in focal stenoses by Schmidt, Wolfram/ Schmitz, Klaus-Peter/ Behrens, Peter/ ...
more infohttps://www.degruyter.com/view/j/cdbme.2017.3.issue-2/cdbme-2017-0029/cdbme-2017-0029.xml?lang=de

Quantification of coronary artery stenosis in vivo. | Circulation ResearchQuantification of coronary artery stenosis in vivo. | Circulation Research

Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
more infohttp://circres.ahajournals.org/content/57/3/341
  • However, the acceptance of FFR by cardiologists contrasts with important voids in knowledge on the basic principles of coronary physiology and of other available techniques that, as an alternative to FFR, allow a more comprehensive assessment of coronary circulation. (abebooks.com)
  • The aim of our study was to assess independent predictors of severe coronary stenosis as detected with ICA in patients with normal MPI and persisting symptoms. (springer.com)
  • As a result, seemingly small changes in diameter are amplified to large changes in stenosis resistance. (ahajournals.org)
  • This extremely important morphologic feature of stenoses permits transient variation in stenosis lumen diameter in response to drugs or to variation in endogenous vasomotor activity or intraluminal pressure. (ahajournals.org)
  • The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. (bioportfolio.com)
  • The greatest potential for this change is normally in the branches (arterioles) of the coronary artery that penetrate the myocardium, rather than those on the surface of the heart. (wikipedia.org)
  • 1 The impact of stenosis of the left main coronary artery on mortality and morbidity among patients waiting to undergo CABG is not clear, but in 2 large retrospective cohort studies the condition was not associated with increased waiting-time mortality. (cmaj.ca)
  • In a study published in this issue 4 (see page 371), Légaré and associates investigate pre- and postoperative mortality and morbidity in a group of patients with stenosis of the left main coronary artery who were scheduled to undergo CABG. (cmaj.ca)
  • Fractional flow reserve (FFR) is the gold standard to guide coronary interventions. (hindawi.com)
  • What are the implications of coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) in patients with intermediate stenosis and high fractional flow reserve (FFR)? (acc.org)
  • To assess the feasibility of exercise perfusion computed tomography (CT) in patients suspected of having hemodynamically significant coronary stenosis. (nih.gov)
  • HealthDay News) - For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial perfusion imaging is feasible and accurate, according to a study published in the March issue of Radiology . (empr.com)
  • Coronary flow reserve can be measured through a variety of methods, including digital subtraction cineangiography with coronary catheterization, doppler echocardiography, and positron emission tomography (PET). (wikipedia.org)
  • FFR is calculated as a ratio of the pressure distal versus pressure proximal to a stenosis following vasodilation. (hindawi.com)
  • However, FFR can only be measured via invasive coronary catheterization, which may result in higher medical cost and complications [ 4 ]. (hindawi.com)
  • Revascularization is commonly recommended when the coronary stenosis leads to FFR ≤ 0.80. (hindawi.com)
  • Pathology studies of CAD have revealed that coronary stenosis is the predominant factor leading to cardiovascular-related events such as myocardial infarction (MI), stroke, and unstable angina. (hindawi.com)
  • After adjusting for several variables, including diabetes, smoking status, hypertension and hypercholesterolaemia, predictors of severe stenosis were male gender, odds ratio (OR) 2.7 (95% confidence interval (CI) 1.5-4.9), older age, OR 1.9 (95% CI 1.02-3.54) previous PCI, OR 2.0 (95% CI 1.0-4.3) and typical angina, OR 2.5 (95% CI 1.4-4.6). (springer.com)
  • When coronary flow reserve is used in medicine, it is often expressed with a numerical value, which is formed by dividing the maximal coronary blood flow by resting blood flow. (wikipedia.org)
  • In the per-patient analysis, a myocardial enhancement ratio cutoff of 0.8 performed best for identifying functionally significant stenosis: Sensitivity was 95% (21 of 22 patients), specificity was 90% (nine of 10 patients), positive predictive value was 95% (21 of 22 patients), negative predictive value was 90% (nine of 10 patients), and accuracy was 94% (30 of 32 patients). (nih.gov)
  • Coronary Flow Reserve and Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis. (acc.org)
  • 1990). "Determination of coronary flow reserve by parametric imaging" (PDF). (wikipedia.org)
  • Independent risk factors for the composite outcome included age greater than 70 years, preoperative renal failure, left ventricular ejection fraction of less than 40%, myocardial infarction in the 7 days before surgery and stenosis of left main artery greater than 70%, but did not include queue assignment. (cmaj.ca)
  • The authors conclude that waiting for surgery with stenosis of the left main artery is safe and not associated with increased pre- or postoperative mortality or morbidity. (cmaj.ca)
  • The second issue is whether postoperative morbidity and mortality are influenced by stenosis of the left main coronary artery. (cmaj.ca)