Narrowing or constriction of a coronary artery.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The circulation of blood through the CORONARY VESSELS of the HEART.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Spasm of the large- or medium-sized coronary arteries.
Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.
Narrowing of the spinal canal.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Narrowing of the pyloric canal with varied etiology. A common form is due to muscle hypertrophy (PYLORIC STENOSIS, HYPERTROPHIC) seen in infants.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Pathologic deposition of calcium salts in tissues.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Pressure, burning, or numbness in the chest.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Elements of limited time intervals, contributing to particular results or situations.
Drugs used to cause dilation of the blood vessels.
Contractile activity of the MYOCARDIUM.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
The hollow, muscular organ that maintains the circulation of the blood.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Substances used to allow enhanced visualization of tissues.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Radiography of blood vessels after injection of a contrast medium.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The innermost layer of the heart, comprised of endothelial cells.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Motion pictures of the passage of contrast medium through blood vessels.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The return of a sign, symptom, or disease after a remission.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Lesions formed within the walls of ARTERIES.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The flow of BLOOD through or around an organ or region of the body.
A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Pathological processes involving any part of the AORTA.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Obstruction of flow in biological or prosthetic vascular grafts.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Freedom from activity.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
The act of constricting.
Computer systems or networks designed to provide radiographic interpretive information.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Narrowing of the pyloric canal due to HYPERTROPHY of the surrounding circular muscle. It is usually seen in infants or young children.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Disease having a short and relatively severe course.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
A stricture of the ESOPHAGUS. Most are acquired but can be congenital.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The vein which drains the foot and leg.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Radiography of the vascular system of the brain after injection of a contrast medium.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.
The vessels carrying blood away from the heart.
Formation and development of a thrombus or blood clot in the blood vessel.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A characteristic symptom complex.
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)
The plan and delineation of prostheses in general or a specific prosthesis.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.

Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. (1/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. METHODS AND RESULTS: FFR and CFR were assessed in 126 consecutive patients with 150 intermediate coronary lesions (between 40% and 70% diameter stenosis by visual assessment). Agreement between outcomes of FFR and CFR, categorized at cut-off values of 0.75 and 2.0, respectively, was observed in 109 coronary lesions (73%), whereas discordant outcomes were present in 41 lesions (27%). In 26 of these 41 lesions, FFR was <0.75 and CFR>or=2.0 (group A); in the remaining 15 lesions, FFR was >or=0.75 and CFR<2.0 (group B). Minimum microvascular resistance, defined as the ratio of mean distal pressure to average peak blood flow velocity during maximum hyperemia, showed a large variability (overall range, 0.65 to 4.64 mm Hg x cm(-1) x s(-1)) and was significantly higher in group B than in group A (2.42+/-0.77 versus 1.91+/-0.70 mm Hg x cm(-1) x s(-1); P:=0.034). CONCLUSIONS: Our findings demonstrate the prominent role of microvascular resistance in modulating the relationship between FFR and CFR and emphasize the importance of combined pressure and flow velocity measurements to evaluate coronary lesion severity and microvascular involvement.  (+info)

Serial intravascular ultrasound analysis of the impact of lesion length on the efficacy of intracoronary gamma-irradiation for preventing recurrent in-stent restenosis. (2/1816)

BACKGROUND: The relation between lesion length and effectiveness of brachytherapy is not well studied. METHODS AND RESULTS: We compared serial (postintervention and follow-up) intravascular ultrasound findings in 66 patients with native coronary artery in-stent restenosis (ISR) who were treated with (192)Ir (15 Gy delivered 2 mm away from the radiation source). Patients were enrolled in the Washington Radiation for In-Stent Restenosis Trial (WRIST; ISR length, 10 to 47 mm; n=36) or Long WRIST (ISR length, 36 to 80 mm; n=30). External elastic membrane, stent, lumen, and intimal hyperplasia (IH; stent minus lumen) areas and source-to-target (intravascular ultrasound catheter to external elastic membrane) distances were measured. Postintervention stent areas were larger in WRIST and smaller in Long WRIST patients (P:<0.0001). At follow-up, maximum IH area significantly increased in both WRIST and Long WRIST patients (P:<0.0001 for both), but this increase was greater in Long WRIST patients (P:=0.0006). Similarly, minimum lumen cross-sectional area significantly decreased in both WRIST and Long WRIST patients (P:<0.05 and P:<0.0001, respectively), but this decrease was more pronounced in Long WRIST patients (P:=0.0567). The maximum source-to-target distance was longer in Long WRIST than in WRIST, and it correlated directly with ISR length (r=0.547, P:<0.0001). Overall, the change in minimum lumen area and the change in maximum IH area correlated with the maximum source-to-target distance (r=0.352, P:=0.0038 and r=0.523, P:<0.0001 for WRIST and Long WRIST, respectively). The variability (maximum/minimum) in IH area at follow-up also correlated with the maximum source-to-target distance (r=0.378, P:<0.0001). CONCLUSIONS: Brachytherapy may be less effective in longer ISR lesions because of the greater variability and longer source-to-target distances in diffuse ISR.  (+info)

Impact of peri-stent remodeling on restenosis: a volumetric intravascular ultrasound study. (3/1816)

BACKGROUND: Vessel remodeling is an important mechanism of late lumen loss after nonstent coronary interventions. However, its impact on in-stent restenosis has not been systematically investigated. METHODS AND RESULTS: Serial volumetric intravascular ultrasound analyses (poststent and follow-up) were performed in 55 lesions treated with a balloon-expandable stent (ACS MultiLink) using standard stent deployment techniques. The vessel volume (VV), lumen volume (LV), and volume bordered by the stent (SV) were measured using Simpson's method. The volume of plaque and neointima outside the stent (peri-stent volume, PSV) and volume of neointima within the stent (intrastent volume) were also measured. The change of each parameter during the follow-up period (follow-up minus poststent) was calculated and then divided by SV to normalize these values (designated as percent change [%]). As expected, %PSV directly correlated with %VV (P<0.0001, r=0.935), with no significant SV. A highly significant inverse correlation was seen between %PSV and the percent change of intrastent volume (P<0.0001, r=0.517). Consequently, %LV significantly correlated with peri-stent remodeling, as measured by %VV (P<0.0001, r=0.602). CONCLUSION: Positive remodeling of the vessel exterior to a coronary stent occurs to a variable degree after stent implantation. There is a distinct trade-off between positive remodeling and in-stent hyperplasia: in segments in which the degree of peri-stent remodeling is less, intrastent neointimal proliferation is greater and accompanied by more significant late lumen loss.  (+info)

Magnesium deficiency in patients with recent myocardial infarction and provoked coronary artery spasm. (4/1816)

This study sought to clarify the relationship between magnesium (Mg) deficiency and coronary artery spasm provoked by pharmacologic agents in patients with a recent acute myocardial infarction (AMI). Twenty-three consecutive patients suffering from AMI were investigated with a Mg retention test (Mg: 0.1 mmol/kg for 4 h) in both the acute phase (within I week (3+/-2 days) of onset) and the subacute phase (3-4 weeks (24+/-6 days) of the onset). Early coronary arteriography was performed in all patients. Coronary stenosis in the infarct-related artery was less than 90% in all patients in the subacute phase. The spasm provocation test was performed in the subacute phase and coronary spasm was defined as transient subtotal or total occlusion in association with angina or electrocardiographic ST-segment deviation. Coronary artery spasm was provoked in only 13 of the 23 patients. Compared with the control subjects (12 patients without coronary artery disease or coronary spasm), the 24-h Mg retention was significantly higher in patients with AMI (acute phase: 78+/-27%, subacute phase: 66+/-32%, vs control: 48+/-12%, p<0.05). In the subacute phase, the 24-h Mg retention decreased in patients without coronary spasm (43+/-26%), but a high level of Mg retention was still observed in patients with coronary spasm (84+/-25%). There was no difference in the serum concentrations of Mg, calcium and phosphorus between the 2 groups on both phases. In conclusion, both Mg deficiency and provoked coronary artery spasm were noted in more than half of the Japanese patients with a recent AMI, suggesting a close association between Mg deficiency and AMI.  (+info)

Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. (5/1816)

Infections are assumed to play a role in coronary artery disease (CAD) and cardiomyopathies. It is unknown whether the seroprevalence of antibodies to these microorganisms is higher in patients with than without CAD. The seroprevalence of antibodies to Bartonella henselae, Borrelia burgdorferi, Chlamydia pneumoniae, Coxiella burnetii, Helicobacter pylori, human granulocytic Ehrlichia, Leptospira, Rickettsia conorii, and Treponema pallidum was assessed prospectively in patients with exertional dyspnea or anginal chest pain who underwent coronary angiography because of suspected CAD. Patients with normal angiograms (NA) were those in whom no more than 50% stenosis of any coronary artery was found. Patients with CAD were patients who underwent percutaneous transluminal coronary angioplasty. There were 50 patients with CAD (9 female) and 62 with NA (25 female), with a mean age of 62 years. All patients had antibodies to at least one microorganism: to B. henselae, 8% of CAD patients and 5% of NA patients; to B. burgdorferi IgG, 14% CAD and 6% NA; to B. burgdorferi IgM, 6% CAD and 3% NA; to C. pneumoniae lipopolysaccharide (LPS) IgA, 76% CAD and 77% NA; to C. pneumoniae LPS IgG, 80% CAD and 90% NA; to C. burnetii, 0% CAD and 5% NA; to H. pylori, 92% CAD and 68% NA; to human granulocytic Ehrlichia, 8% CAD and 3% NA; to Leptospira IgG, 4% CAD and 2% NA; to R. conorii, 10% in both groups; and to T. pallidum, 2% CAD and 0% NA. The seroprevalence of antibodies to micro-organisms known to induce arterial and myocardial damage does not differ between patients with CAD and NA.  (+info)

Dobutamine stress echocardiography versus quantitative technetium-99m sestamibi SPECT for detecting residual stenosis and multivessel disease after myocardial infarction. (6/1816)

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN: Prospective study. SETTING: University hospital. METHODS: 75 patients underwent simultaneous DSE and mibi SPECT at (mean (SD)) 5 (2) days after a first acute myocardial infarct. Quantitative coronary angiography was performed in all patients after imaging studies. RESULTS: Significant stenosis (> 50%) of the infarct related artery was detected in 69 patients. Residual ischaemia was identified by DSE in 55 patients and by quantitative mibi SPECT in 49. The sensitivity of DSE and mibi SPECT for detecting significant infarct related artery stenosis was 78% and 70%, respectively, with a specificity of 83% for both tests. The combination of DSE and mibi SPECT did not change the specificity (83%) but increased the sensitivity to 94%. Mibi SPECT was more sensitive than DSE for detecting mild stenosis (73% v 9%; p = 0.008). The sensitivity of DSE for detecting moderate or severe stenosis was greater than mibi SPECT (97% v 74%; p = 0.007). Wall motion abnormalities with DSE and transient perfusion defects with mibi SPECT outside the infarction zone were sensitive (80% v 67%; NS) and highly specific (95% v 93%; NS) for multivessel disease. CONCLUSIONS: DSE and mibi SPECT have equivalent accuracy for detecting residual infarct related artery stenosis of >/= 50% and multivessel disease early after acute myocardial infarction. DSE is more predictive of moderate or severe infarct related artery stenosis. Combined imaging only improves the detection of mild stenosis.  (+info)

Value of fractional flow reserve in making decisions about bypass surgery for equivocal left main coronary artery disease. (7/1816)

OBJECTIVE: To investigate the value of coronary pressure derived fractional flow reserve (FFR) measurements in supporting decisions about medical or surgical treatment in patients with angiographically equivocal left main coronary artery stenosis. DESIGN: A two centre prospective single cohort follow up study. INTERVENTIONS: FFR of the left main coronary artery was determined in 54 consecutive patients with angiographically equivocal left main coronary artery disease. If FFR was >/= 0.75, medical treatment was chosen; if FFR was < 0.75, surgical treatment was chosen. MAIN OUTCOME MEASURES: Freedom from death, myocardial infarction, or any coronary revascularisation procedure. RESULTS: In 24 patients (44%), FFR was >/= 0.75 and medical treatment was chosen (medical group). In the remaining 30 patients (56%), FFR was < 0.75 and bypass surgery was performed (surgical group). Mean (SD) follow up was 29 (15) months (range 12-65 months). Survival among patients at three years of follow up was 100% in the medical group and 97% in the surgical group. Event-free survival was 76% in the medical group and 83% in the surgical group. CONCLUSIONS: FFR supports decision making in equivocal left main coronary artery disease. If FFR is below 0.75, the decision for bypass surgery is supported. If FFR is above 0.75, a conservative approach is justified.  (+info)

Coronary thermodilution to assess flow reserve: experimental validation. (8/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are indices of coronary stenosis severity that provide the clinician with complementary information on the contribution of epicardial arteries and microcirculation to total resistance to myocardial blood flow. At present, FFR and CFR can only be obtained by 2 separate guidewires. The present study tested the validity of the thermodilution principle in assessing CFR with one pressure-temperature sensor-tipped guidewire. METHODS AND RESULTS: In an in vitro model, absolute flow was compared with the inverse mean transit time (1/T(mn)) of a thermodilution curve obtained after a bolus injection of 3 mL of saline at room temperature. A very close correlation (r>0.95) was found between absolute flow and 1/T(mn) when the sensor was placed >/=6 cm from the injection site. In 6 chronically instrumented dogs (60 stenoses; FFR from 0.19 to 0.98), a significant linear relation was found between flow velocity and 1/T(mn). A significant correlation was found between CFR(Doppler), which was calculated from the ratio of hyperemic to resting flow velocities, and CFR(thermo), which was calculated from the ratio of resting to hyperemic T(mn) (r=0.76; SEE=0.24; P<0.001). CONCLUSION: The present findings demonstrate the validity of the thermodilution principle to assess CFR. Because the pressure-temperature sensor was mounted in a commercially available angioplasty guidewire, this technique permits simultaneous measurements of CFR and FFR.  (+info)

TY - JOUR. T1 - Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis. AU - Kim, Young Hak. AU - Park, Duk Woo. AU - Kim, Won Jang. AU - Lee, Jong Young. AU - Yun, Sung Cheol. AU - Kang, Soo Jin. AU - Lee, Seung Whan. AU - Lee, Cheol Whan. AU - Hong, Myeong Ki. AU - Park, Seong Wook. AU - Park, Seung Jung. PY - 2010/6/8. Y1 - 2010/6/8. N2 - Objectives: This study was designed to examine the impact of the extent of coronary disease on long-term outcomes after coronary stenting or coronary artery bypass graft (CABG) surgery for unprotected left main coronary artery (ULMCA) stenosis. Background: The differential outcome of ULMCA revascularization according to the coronary involvement remains uncertain. Methods: From the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, 2,240 patients with ULMCA ...
In the United States, ULMCA PCI is performed primarily in patients with a high burden of comorbidities and frequently in those with high-urgency clinical presentations. In this population, in-hospital mortality was substantially higher in those with ULMCA disease who were treated percutaneously; however, this early risk is driven by those with high-urgency, rather than lower-urgency, presentations.. Among ULMCA patients selected for PCI in the United States, 30-month mortality is high (42.7%), with a predominance of cardiovascular events. These findings are especially notable when compared to the 10% mortality reported at 30 months in the MAIN-COMPARE (Korean Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) study (11), and the 4% mortality reported at 1 year in the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) trial (12). The increased patient age, burden of comorbidities, and ...
The long-term safety and efficacy of drug-eluting stent (DES) implantation in the treatment of unprotected left main coronary artery (LMCA) stenosis is still a matter of debate. All consecutive patients (pts) who had sirolimus (SES, Cypher, Cordis, Johnson and Johnson Company, Warren, NJ) or paclitaxel-eluting stent (PES, Taxus, Boston Scientific, Natick, MA) electively implanted in de novo lesions on LMCA between March 2002 and July 2006 were analyzed. A total of 267 patients were treated: 107 with PES and 160 with SES. Sixty-four (23.4%) patients were diabetics, 95 (35.6%) had unstable angina, mean age was 64.5±11.6 years and LVEF 52.2±10.7 %. High mortality risk scores (Euroscore ,6) were present in 84 (31.5%) of the patients. Glycoprotein IIb/IIIa inhibitors were used in 50 (18.7%) patients, 80 (29.9%) underwent intravascular ultrasound. Distal left main lesions were present in 223 (83.5%) of the patients: 209 bifurcations and 14 trifurcations. Both branches were stented in 108 (48.4%) ...
TY - JOUR. T1 - Current management of unprotected left main coronary artery disease. T2 - Run-in survey of the RITMO (Registro Italiano sul Trattamento del tronco coMune non protettO) study. AU - Sheiban, Imad. AU - Sillano, Dario. AU - Biondi-Zoccai, Giuseppe G L. AU - De Servi, Stefano. AU - Tamburino, Corrado. AU - Marzocchi, Antonio. AU - Trevi, Gian Paolo. AU - Moretti, Claudio. PY - 2009/9. Y1 - 2009/9. N2 - The optimal approach for a significant unprotected left main coronary stenosis (ULM) is debated, in light of the recent progresses of percutaneous coronary intervention (PCI). However, coronary artery bypass grafting (CABG) is still considered the first choice treatment. Randomized trials comparing PCI and CABG are ongoing, yet patient selection will considerably limit their clinical applicability. We thus designed a prospective multicenter registry which will include patients with ULM disease independently from the subsequent medical, interventional or surgical treatment: the RITMO ...
TY - JOUR. T1 - The absence of evidence is not the evidence of absence. T2 - A case report on the challenges in diagnosing ostial left main stenosis. AU - Shaik, Ayesha. AU - Mosleh, Wassim. AU - Dahal, Khagendra. AU - Pickett, Christopher. AU - Azrin, Michael. N1 - Publisher Copyright: © 2020 Wiley Periodicals LLC. PY - 2021/4/1. Y1 - 2021/4/1. N2 - Because left main (LM) coronary artery stenosis is known to have higher mortality and morbidity compared to lesions in other territories, an early diagnosis and management are crucial to prevent worse outcomes. Due to limitations of coronary angiography (CA), the diagnosis of ostial LM stenosis solely based on CA may result in underdiagnosis of such lesions. Therefore, additional testing is often needed either by pressure wire or intravascular ultrasound (IVUS) to make appropriate diagnosis. We, hereby, present a case of left main ostial stenosis in a 56-year-old male that was missed on multiple coronary angiograms, and highlights many of the ...
Allograft vasculopathy is the leading cause of death and morbidity after the first year of transplantation. Its prevalence is high: 11%, 22%, and 45% at one, two, and four years after transplantation, respectively.13,14 The accelerated coronary artery disease involves both the epicardial and the intramyocardial arteries. Its diagnosis is difficult because of the absence of angina in the denervated heart and the low sensitivity of non-invasive stress testing.15 The first manifestation of allograft vasculopathy is often congestive heart failure, ventricular arrhythmias, or sudden death.16 The ineffective medical treatment and the limited suitability of CABG and retransplantation have motivated interest in PCI for the subset of heart transplant recipients presenting with allograft vasculopathy in proximal segments. Schnetzler and colleagues17 reported 94.3% primary success (, 50% residual stenosis) in 53 lesions. Two of these patients had symptomatic left main stenosis, which were dilated with ...
Definition of Left main coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Left main coronary artery? Meaning of Left main coronary artery as a legal term. What does Left main coronary artery mean in law?
All the papers appraised note an association between this pattern and severe stenosis of the LMCA or 3-vessel disease. However, the evidence identified from nine cohort studies consistently shows that lone ST elevation in lead aVR has little diagnostic value for identifying patients with stenosis of the LMCA. Both sensitivity and specificity are suboptimal to guide clinical decision making. The evidence suggests that diagnostic performance may improve when there is accompanying diffuse ST depression. Kosuge et al 8 found that such changes have a specificity of 93% for LMCA stenosis or 3-vessel disease, although the positive predictive value in that sample was only 58%, which limits the value of the finding for ruling in LMCA stenosis. As such, taken alone this finding could not be used to guide the need for primary percutaneous coronary intervention, for example. However, as patients with LMCA stenosis are at particularly high risk, ST elevation in aVR may help to identify patients for early ...
Background and Purpose: Acute myocardial infarction(AMI) occurs in 1-2% of patients treated with carotid artery stenting(CAS), and is considered as one of the most serious perioperative complication. We assessed coronary artery stenosis in patients treated with CAS using coronary CTA or coronary angiography.. Methods: Consecutive sixty-two patients (47 men, mean age 73.4 years) treated with CAS were examined by coronary CTA or angiography within 3 months before CAS between January 2010 and August 2012. In patients suspected coronary artery stenosis by coronary CTA, coronary angiography was performed. Significantly coronary artery stenosis was defined as that greater than 75%.. Results: CAS was performed in 62 patients, and coronary artery was evaluated in 57 patients. Patients with allergic reaction for contrast agents, renal failure, and poor general condition were excluded from this study. Thirty-eight patients had significant coronary artery stenosis. Twenty-nine of them had any history of ...
Catheter intervention treatment is now widely accepted as a nonsurgical revascularization option for adult patients with coronary artery disease. However, the experiences in KD have been limited.7,10,11 In contrast to the success of PTCA for treatment of atheromatous coronary artery disease in the adult, it was reported10,11 that PTCA is not as effective in the dilatation of the severely calcified stenotic lesions in patients with KD via balloon angioplasty. In this study, we introduced the new device of PTCRA, which was effective in ablating stenotic vessel lesions with hard calcification in the children with coronary artery stenosis after KD. Although PTCA was effective in only one of our four patients, the other three required PTCRA to ablate the hardened stenotic coronary lesions.. The mechanism of coronary artery stenosis in KD is uncertain. One possibility is acute occlusion by massive thrombus formation in the coronary aneurysms, which occur mostly in acute or subacute stages of illness. ...
The use of percutaneous coronary intervention (PCI) for unprotected left main coronary artery stenosis is increasing but it remains unclear whether this approach is non-inferior to coronary artery bypass grafting (CABG). Both the Nordic-Baltic-British left main revascularisation study (NOBLE, n=1201) and Evaluation of an everolimus eluting stent versus coronary artery bypass surgery for effectiveness of left main revascularisation study (EXCEL, n=1905) randomised patients with severe left main coronary artery stenosis to PCI or CABG to address this question. Though similar, there are important differences in these studies design and results. Primary outcomes were defined as all cause death, stroke and non-procedural myocardial infarction (MI) in both trials with the addition of repeat revascularisation in NOBLE and post-procedural MI in EXCEL. Other study differences include intended duration of follow-up, non-inferiority margins, allowable coronary complexity, and stent type. The prevalence of ...
Video 297e-30 The bifurcation lesion in the left main coronary artery extending into the LCx and LAD ostia is treated using a culotte technique. First, a drug-eluting stent is placed in the left main coronary artery and into the proximal LCx. ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Abstract. Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). This has lead to the development of several algorithms for automatic detection and grading of coronary stenoses. However, most of these methods focus on detecting calcified plaques only. A few methods that can also detect and grade non-calcified plaques require substantial user involvement. In this paper, we propose a fast and fully automatic system that is capable of detecting, grading and classifying coronary stenoses in CCTA caused by all types of plaques. We propose a four-step approach including a learning-based centerline verification step and a lumen crosssection estimation step using random regression forests. We show state-of-the-art performance of our method in experiments conducted on a set of 229 CCTA
Then we fast forward till September 15th 1977, when Dr A Greuntzig successfully dilated an LAD stenosis in a Swiss dentist. This further proved that the goal post has moved again. That it was safe ( with all the appropriate training and precautions ) to safely work within coronary arteries. This began the journey of percutaneous coronary interventions . One by one, the goal post moved. Initially, Dr Greuntzig only advocated angioplasty ( as the new procedure was initially called ) for single lesion CAD. Then with better equipment and devices we began to do two vessels and then three vessels disease, much to the chargrin of our cardiac surgeons. The goal post was moving and still is. Coronary interventionist, ably led by the Korean Dr SJ Park and the French, Dr Jean Marco and Fajadet, began to take on left main stem disease, initially in the protected left main ( left main disease with a good functioning bypass graft ), and later in unprotected left main stem disease ( isolated ) and gradually ...
Coronary artery disease had spread in a larger number among the people worldwide. According to statistics, about 50 percent of the patients suffered from left main coronary artery stenosis. Many of the people possess the risk of the heart failure due to blockage in vessels that mainly occurs at the left main coronary artery. This Read more ...
For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial perfusion imaging is feasible and accurate.
Among the bifurcation type, bifurcation lesion without significant side branch stenosis (,50%) usually did not require side branch stenting, but owing to several putative mechanism including dissection, thrombosis formation, embolization of plaque debris, ostial compromise by displaced stent strut, and snow plow effect, the side branch might be compromised. In this situation, the strategy to achieve optimal results has not been reported. Recently, FFR study showed that most jailed side branch (vessel size ,2.0 mm. DS,50%) after main branch stenting did not have functional significance. We compared strategies with or without routine kissing balloon dilatation for less than 50% stenosis after simple DES crossing for bifurcation lesions (bifurcation type 1.1.0, 1.0.0, and 0.1.0 according to Medina classification) with serial change of FFR measurement ...
Coronary Stenosis is that situation in which a coronary artery got lessened and backed up in the company of materials like cholesterol or fat. Coronary artery
Watch this LIVE case if you want to learn more about left main PCI, unprotected left main angioplasty strategy and distal LM bifurcation stenting.A 64-year-old male with distal LM bifurcation, LAD and LCX diseases:Two-stent techniquesIVUS assessment
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
By and For the Interventional Cardiovascular community. Sharing knowledge, experience and practice in cardiovascular interventional medicine. ...
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In Reply: Dr Dewey and colleagues asked about discrimination of ischemia by FFRCT vs CT. Discrimination was determined by area under the receiver operating char
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Spheric, ovoid or irregular intraluminal filling defect or lucency surrounded on three sides by contrast medium seen just distal or within the coronary stenosis in multiple projections or a visible embolization of intraluminal material downstream ...
AUM Cardiovasculars CADence System for Coronary Artery Stenosis Testing via @medgadget
This work demonstrates that the sequence of a Ge co-implant with a B,inf,2,/inf,H,inf,6,/inf, PLAD in the source/drain is very… Expand ...
TY - JOUR. T1 - Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements. AU - Cook, Christopher M.. AU - Jeremias, Allen. AU - Petraco, Ricardo. AU - Sen, Sayan. AU - Nijjer, Sukhjinder. AU - Shun-Shin, Matthew J.. AU - Ahmad, Yousif. AU - de Waard, Guus. AU - van de Hoef, Tim. AU - Echavarria-Pinto, Mauro. AU - van Lavieren, Martijn. AU - Al Lamee, Rasha. AU - Kikuta, Yuetsu. AU - Shiono, Yasutsugu. AU - Buch, Ashesh. AU - Meuwissen, Martijn. AU - Danad, Ibrahim. AU - Knaapen, Paul. AU - Maehara, Akiko. AU - Koo, Bon-Kwon. AU - Mintz, Gary S.. AU - Escaned, Javier. AU - Stone, Gregg W.. AU - Francis, Darrel P.. AU - Mayet, Jamil. AU - Piek, Jan J.. AU - van Royen, Niels. AU - Davies, Justin E.. PY - 2017/12/26. Y1 - 2017/12/26. KW - CFR. KW - coronary flow reserve. KW - coronary physiology. KW - FFR. KW - fractional flow reserve. KW - iFR. KW - instantaneous wave-free ...
The main purpose of this study is to observe the incidence of major adverse cardiac and cerebrovascular events (MACCE), target vessel failure (TVF), target vessel revascularization (TVR) and stent thrombosis out to 5 years after the procedure in patients who underwent percutaneous coronary intervention (PCI) with everolimus-eluting stents for unprotected left main coronary artery (ULMCA) disease and lesions involving the ULMCA in Japan. The investigators will also establish a method of adjustment to the Japanese version of the SYNTAX score by conducting an assessment using the SYNTAX score recently reported in the US and Europe as well as the EuroSCORE, and by clarifying the differences of PCI procedures and treatment results in Japan with those reported in the US and Europe ...
TY - JOUR. T1 - Intravascular ultrasound predictors of target lesion revascularization after stenting of protected left main coronary artery stenoses. AU - Hong, Myeong Ki. AU - Mintz, Gary S.. AU - Hong, Mun K.. AU - Pichard, Augusto D.. AU - Satler, Lowell F.. AU - Kent, Kenneth M.. AU - Popma, Jeffery J.. AU - Leon, Martin B.. PY - 1999/1/15. Y1 - 1999/1/15. N2 - We evaluated the predictors of late clinical outcomes after stenting of protected left main coronary artery (LMCA) stenoses. Intravascular ultrasound (IVUS) guided stenting of protected LMCA stenoses was performed in 87 consecutive patients between January 1994 and December 1996. Results were evaluated using conventional (clinical, angiographic, and IVUS) methodology. Late (12 month) clinical follow-up information was obtained in all patients. Initial procedural success was achieved in 86 patients (99%). There was 1 in- hospital death (in the 1 patient with a procedural failure). There were no other in-hospital complications, ...
Fractional flow reserve (FFR) is a well-validated tool for determining the functional significance of a coronary artery stenosis, facilitating clinical decisions regarding the need for revascularization. FFR-guided revascularization improves clinical and economic outcomes. However, its application remains challenging in certain complex anatomic subsets, including left main coronary artery stenosis, bifurcation disease, and saphenous vein graft disease. This article reviews recent data supporting the use of FFR in these complex anatomic subsets. [Rev Cardiovasc Med.
Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. The present analysis included the 607 patients from the FAME 2 trial (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation 2) in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74±0.16), and DS (by quantitative coronary analysis) varied from 8% to 98% (average 53±15). The primary end point, defined as vessel-oriented clinical end point (VOCE) at 2 years, was a composite of prospectively adjudicated cardiac death, vessel-related myocardial infarction, vessel-related urgent, and not urgent revascularization. The stenoses were divided into 4 groups according to FFR and %DS values: positive concordance (FFR≤0.80; DS≥50%), negative concordance (FFR|0.80; DS
TY - JOUR. T1 - Performance of computed tomography-derived fractional flow reserve using reduced-order modelling and static computed tomography stress myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis. AU - Ihdayhid, Abdul Rahman. AU - Sakaguchi, Takuya. AU - Linde, Jesper J.. AU - Sørgaard, Mathias H.. AU - Kofoed, Klaus F.. AU - Fujisawa, Yasuko. AU - Hislop-Jambrich, Jacqui. AU - Nerlekar, Nitesh. AU - Cameron, James D.. AU - Munnur, Ravi K.. AU - Crosset, Marcus. AU - Wong, Dennis T.L.. AU - Seneviratne, Sujith K.. AU - Ko, Brian S.. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Aims: To compare the diagnostic performance of a reduced-order computed tomography-derived fractional flow reserve (CT-FFR) technique derived from luminal deformation and static CT stress myocardial perfusion (CTP).Methods and results: Forty-six patients (84 vessels) with suspected coronary artery disease from a single institution planned for elective coronary angiography ...
Fractional flow reserve (FFR) is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine the likelihood that the stenosis impedes oxygen delivery to the heart muscle (myocardial ischemia). FFR is a novel and potentially clinically useful mathematical solution for estimation of stenotic coronary artery atherosclerosis. Reliability/collaborative measurement between capable laboratories in measuring this essential metric appears muddled in a proprietary race to claim cardiac mathematics dedicated to risk in ischemic cardiac disease. Proprietary claims of cardiac mathematics have not been previously argued in patent law. Fractional flow reserve is defined as the pressure after (distal to) a stenosis relative to the pressure before the stenosis. The result is an absolute number; an FFR of 0.80 means that a given stenosis causes a 20% drop in blood pressure. In other words, FFR expresses the ...
Diabetes mellitus (DM), low ejection fraction (EF), and the extent of coronary artery disease (CAD) have all been identified as predictors of cardiovascular eve...
Methods and Results-Using intracoronary measurements, 91 coronaries (78 patients) with intermediate stenoses were classified in 4 FFR and coronary flow reserve (CFR) agreement groups, using FFR,0.80 and CFR,2 as cutoffs. Index of microcirculatory resistance (IMR) and atherosclerotic burden (Gensini score) were also assessed. MCD was assumed when IMR≥29.1 (75th percentile). Fifty-four (59.3%) vessels had normal FFR, from which only 20 (37%) presented both normal CFR and IMR. Among vessels with FFR,0.80, most (63%) presented disturbed hemodynamics: abnormal CFR in 28 (52%) and MCD in 18 (33%). Vessels with FFR,0.80 presented higher IMR [adjusted mean 27.6 (95% confidence interval, 23.4-31.8)] than those with FFR≤0.80 [17.3 (95% confidence interval, 13.0-21.7), p=0.001]. Atherosclerotic burden was inversely correlated with CFR (r=−0.207,P=0.055), and in vessels with FFR,0.80 and CFR,2 (n=28, 39%), IMR had a wide dispersion (7-72.7 U), suggesting a combination of diffuse atherosclerotic ...
OBJECTIVE To compare the consistency of angiography-guided and fractional flow reserve (FFR)-guided management strategy for intermediate coronary lesions. METHODS The patients whose coronary intermediate lesions were assessed by measuring FFR from November 2012 to August 2014. The stenosis percentage and value of FFR during the procedure were collected. All the image data were collected and four experienced interventional cardiologists were invited to assess the target lesions and make a management strategy independently. The consistency of angiography-guided and fractional flow reserve-guided management strategy were analyzed. RESULTS In the study, 151 patients were included, of whom, 70.2% were male, the average age was (62.7±9.6) years, 169 vessels were assessed by measuring FFR, 1 being left main, 116 left anterior descending, 27 left circumflex branch, and 25 right coronary artery. There were some correlationship between the stenosis percentage judged by four interventional cardiologists and
TY - JOUR. T1 - The long-term clinical outcome of T-stenting and small protrusion technique for coronary bifurcation lesions. AU - Naganuma, Toru. AU - Latib, Azeem. AU - Basavarajaiah, Sandeep. AU - Chieffo, Alaide. AU - Figini, Filippo. AU - Carlino, Mauro. AU - Montorfano, Matteo. AU - Godino, Cosmo. AU - Ferrarello, Santo. AU - Hasegawa, Tasuku. AU - Kawaguchi, Masanori. AU - Nakamura, Sunao. AU - Colombo, Antonio. PY - 2013/6. Y1 - 2013/6. N2 - Objectives This study sought to report long-term clinical outcomes in patients treated with the provisional T-stenting and small protrusion (TAP) technique. Background Several strategies have been proposed for treating bifurcation lesions, each with its own merits and technical challenges. The TAP technique is a relatively new strategy that is technically less challenging, ensures complete coverage of the side-branch ostium, and minimizes stent overlap. Although there is reasonable amount of data for other bifurcation strategies, the long-term ...
Evidence-based recommendations on QAngio XA 3D QFR and CAAS vFFR imaging software for assessing coronary stenosis during invasive coronary angiography
Second generation drug-eluting stents are safe and effective in treatment of left main coronary artery disease. A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the worlds premier educational meeting specializing in interventional cardiovascular medicine.. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often considered at high-risk of adverse cardiovascular events. The use of first generation drug-eluting stents in these lesions has previously been shown to be feasible, safe, and effective. The second-generation zotarolimus-eluting (ZES) and everolimus-eluting stents (EES), used more widely in clinical practice at present, perform very similarly in ...
In the present study, we compared the prognostic impact of treatment strategy on clinical outcomes according to bifurcation lesion location (LM vs. non-LM bifurcation lesion) using data from a large, multicenter, dedicated bifurcation registry. The main findings of the present study are that compared with the 1-stent strategy, the 2-stent strategy was associated with higher risks of cardiovascular events in patients with LM bifurcation lesion, whereas this association was attenuated in those with non-LM bifurcation lesions, and that significant interactions were present between treatment strategy and bifurcation lesion location in the adjusted risks of target lesion failure, target lesion revascularization, and target vessel revascularization.. Coronary bifurcation lesions are complex, and their treatment continues to be the subject of substantial debate, even in the DES era (1,2). Previous randomized trials comparing the 1-stent strategy with the elective 2-stent strategy (mainly in patients ...
OBJECTIVES: The aims of the present study were to investigate the applicability of quantitative flow ratio (QFR) in patients with 3-vessel disease and to demonstrate the impact of functional SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score derived from QFR (fSSQFR) on clinical outcomes. BACKGROUND: The applicability of QFR in patients with 3-vessel disease and the feasibility of fSSQFR have not yet been investigated. METHODS: All lesions interrogated using instantaneous wave-free ratio and/or fractional flow reserve in the SYNTAX II trial were retrospectively screened and analyzed for QFR. The diagnostic performance of QFR was investigated using hybrid wire-derived pressure assessment (instantaneous wave-free ratio and fractional flow reserve), used in the trial as a reference. Patients with analyzable QFR in 3 vessels were stratified according to fSSQFR to evaluate its clinical prognostic value on the basis of 2-year patient-oriented composite endpoint.
Intracoronary transluminal attenuation gradient in coronary CT angiography for determining coronary artery stenosis Academic Article ...
ST. PAUL, Minn.--(BUSINESS WIRE)--St. Jude Medical, Inc. (NYSE: STJ), a global medical device company, today announced its wireless PressureWire™ Aeris technology, which aids in the diagnosis and treatment of coronary artery blockages by measuring Fractional Flow Reserve (FFR), will now be available to hospitals using the Philips Xper Flex Cardio physiomonitoring system. Physicians will have greater access to the markets only wireless FFR measurement system through this new Philips agreement. FFR measurements indicate the severity of blood flow blockages in the coronary arteries, allowing physicians to better identify which specific lesion or lesions are responsible for a patients ischemia, a deficiency of blood supply to the heart caused by blood flow restriction. The PressureWire Aeris technology helps physicians determine the best treatment options for patients during coronary interventions, such as stent procedures. The PressureWire Aeris system offers a secure, wireless interface between ...
In this study, beta-blockade blunted the ischemic response to dobutamine stress, an effect only partially eliminated by atropine. Importantly, this study also provided hemodynamic and biochemical correlates of this phenomenon and demonstrated that beta-blockade causes a shift in the relation between regional wall thickening and coronary flow per heartbeat.. Dobutamine stress in the non-beta-blocked state. This study confirmed the results of previous clinical (3,9) and experimental studies (20), in that incremental doses of dobutamine induce a characteristic biphasic pattern in wall thickening in regions supplied by significant coronary artery stenosis but without baseline regional wall motion abnormalities. This consisted of an initial increase in wall thickening at low doses of dobutamine, with subsequent significant decreases in wall thickening to or below baseline values at higher doses. In contrast, in normally perfused regions, regional wall thickening increased significantly at low doses ...
This cross-sectional study evaluates the association of major adverse cardiac events (MACE) integrated with fractional flow reserve as the management strategy f
The Heart (Function (The left main coronary artery, on one side of the…: The Heart (Function, Facts (The heart pumps about 6 quarts (5.7 liters) of blood throughout the body, The heart beats about 100,000 times per day (about 3 billion beats in a lifetime), An adult heart beats about 60 to 80 times per minute, The heart weighs between about 10 to 12 ounces (280 to 340 grams) in men and 8 to 10 ounces (230 to 280 grams) in women, Newborns hearts beat faster than adult hearts, about 70 to 190 beats per minute, A human heart is roughly the size of a large fist, The heart is located in the center of the chest, usually pointing slightly left ), Anatomy (Two lower chambers (the ventricles), The right atrium and right ventricle together make up the right heart, Two upper chambers (the atria), The left atrium and left ventricle make up the left heart, The physiology of the heart comes down to structure, electricity and plumbing , A double-walled sac called the pericardium encases the heart, which serves
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Assessment of myocardial blood volume changes during adenosine using MCE can be used for the determination of the functional relevance of coronary stenoses of intermediate angiographic severity if MVO2 is increased during adenosine.
To the best of our knowledge, this is the only prospective, randomized study with long-term results at 7 years in patients with isolated lesions of the proximal LAD treated by either PCI with SES or MIDCAB surgery. There were no significant differences in the composite primary endpoint and individual hard endpoints such as cardiac death and myocardial infarction between PCI with SES and MIDCAB. However, TVR was more frequent with PCI.. Current guidelines for revascularization of stable coronary artery disease recommend a stop of the procedure and discussion of further therapy with the patient and the heart team, after the discovery of an isolated proximal LAD stenosis. In American guidelines, revascularization in patients with single-vessel disease and an isolated proximal LAD stenosis PCI has a Class IIb Level of Evidence: B recommendation and surgery with left internal mammary artery a Class IIa B recommendation, whereas in European guidelines PCI has a Class IIa Level of Evidence: B ... Physiological Assessment of Coronary Stenoses and the Microcirculation (9781447152446) and a great selection of similar New, Used and Collectible Books available now at great prices.
Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosis Journal Article published 17 Sep 2013 in Journal of International Medical Research volume 41 issue 5 on pages 1520 to 1531 Authors: Dan-Dan Dong, Kai Wang, Dan Wang, Tong Zhang, Ying-Feng Tu, Bao-Zhong Shen. ...
BACKGROUND: The value of angiographic follow-up in unprotected left main (ULM) stenting remains undefined. METHODS: The FAILS-2 registry included consecutive patients presenting with a critical lesion of an ULM treated with second generation drug eluting stents in 6 centers from June 2007 to January 2015. Patients were stratified into two groups: those discharged with planned angiographic follow-up and those with clinical follow-up. MACE (Major Adverse Clinical Events, a composite end point of death, myocardial infarction, TLR, and ST) was the primary end point, while each component was a secondary endpoint Sensitivity analysis was performed for patients treated with a provisional or a two-stent strategy ...
BACKGROUND: Postoperative myocardial injury (PMI) is a strong predictor of mortality after noncardiac surgery. PMI is believed to be attributable to coronary artery disease (CAD), yet its etiology is largely unclear. We aimed to quantify the prevalence of significant CAD in patients with and without PMI using coronary computed tomography angiography (CCTA). METHODS: This prospective cohort study included patients of 60 years or older without a history of cardiac disease and with and without PMI after intermediate- to high-risk noncardiac surgery. PMI was defined as any serum troponin I level ≥60 ng/L on the first 3 postoperative days. Main exclusion criteria were known cardiac disease and postoperative ischemic symptoms or electrocardiography abnormalities. Noninvasive imaging consisted of a postoperative CCTA. Main outcome was CAD defined as >50% coronary stenosis on CCTA. RESULTS: The analysis included 66 patients. Median peak troponin levels in the PMI (n = 46) and control group (n = 20) ...
A method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed. In one embodiment, medical image data of the patient including the stenosis
Coronary CT angiography (CCTA) identified plaques in acute MI patients whose coronary angiograms did not produce evidence of significant coronary stenosis.
If we think we have unraveled all the mysteries of human coronary blood flow we are sadly mistaken . Most cardiac physicians spend their prime life in opening the obstructed coronary arteries playing a role of coronary plumber. Like any plumber , it is not going to be one time job and our patients …
A new study clarifies that statins are the greatest medical fraud of all time. The claims made for them are false. The amount of harm they do is staggering, resulting in millions of lives devastated and ended. The worst part of all, though, is that it was entirely predictable-but studies were designed to hide the truth. The media, the health agencies, and the doctors all provided cover for Big Pharma. After all, there was money to be made.. ...
Left main ostial lesion remains a challenging task .A new stent design is proposed here. The lesion The hardware The technique Final message This thought came when I recently encountered a patient with a left main ostial stent which was projecting well into aortic root .It is an open access patency ,whoever is capable of…
I was wondering if anyone knows why FFR (Fractional flow reserve) isnt used in all cath labs? I read about a good example last year where a man was having a heart attack. In the Cath lab they used FFR...
The vascular system can be damaged from cocaine abuse. Arterial thrombosis, coronary stenosis are just two of some of the harmful effects that can be caused abd cause a person to have a stroke. See how this can happen.
We prospectively analyzed all consecutive patients treated at our center for bifurcation lesions from 2011-2015 and compared the angiographic and clinical outcomes of patients with left main bifurcation lesions vs those with non-left main bifurcation ...
I think he is saying NT or angi or something. I cannot tell. This is in the area of her abdomen and she is being seen for not having bowel movements for two days ...
If serial stenoses are less than 3 vessel reference diameters apart, they should be scored as one lesion. However, stenoses at a greater distance from each other (more than 3 vessel reference diameters), are considered as separate lesions ...
ACIST Medical Systems - US - Advancing diagnostic assessments with Rapid FFR The ACIST RXi® system combines accurate and reliable FFR measurements with the advantages of Rapid Exchange technology.
Transluminal dilatation of coronary-artery stenosis; A. R. Gruentzig - erster Bericht über eine Koronardilatation PMID 74678 ...
"Evaluation of transluminal angioplasty of chronic coronary artery stenosis. Value and limitations assessed in fresh human ... Atherosclerosis Peripheral artery disease Peripheral vascular disease Stenosis Systemic circulation Thrombosis "What Is ...
... showing luminal stenosis in coronary artery atherosclerosis. "Pathology News: Newsletter, Vol. 3, No. 4: April ...
"Percutaneous transluminal angioplasty for shepherd's crook right coronary artery stenosis". Catheterization and Cardiovascular ... In medicine, the term shepherd's crook is used to describe a right coronary artery that follows an unusually high and winding ... and Classifying Congenital Anomalies of the Coronary Arteries". RadioGraphics. 32 (2): 453-468. doi:10.1148/rg.322115097. ISSN ...
"Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis". PLOS ONE. 7 (8): e43378. Bibcode:2012PLoSO ... "Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women". Circulation ...
CAST system is available for the detection of significant (>50%) coronary stenosis in coronary CT angiography (cCTA) studies. ... Halpern, EJ; Halpern, DJ (March 2011). "Diagnosis of coronary stenosis with CT angiography comparison of automated computer ... May 2010). "Automated computer-aided stenosis detection at coronary CT angiography: initial experience". Eur Radiol. 20 (5): ... April 2012). "Feasibility of an automatic computer-assisted algorithm for the detection of significant coronary artery disease ...
... , namely coronary ostial stenosis, is the occlusion of coronary ostium. Causing factors include atherosclerosis, ... Angelini, P (2012). "Congenital Coronary Artery Ostial Disease". Tex Heart Inst J. 39 (1): 55-9. PMC 3298900. PMID 22412228.. ...
In certain cases, coronary artery anatomy cannot be clearly viewed using echocardiogram. In this case, cardiac catheterization ... This open-heart surgery is designed to relieve the right ventricular outflow tract stenosis by careful resection of muscle and ... Daehnert I, Wiener M, Kostelka M (May 2005). "Covered stent treatment of right pulmonary artery stenosis and Waterston shunt". ... Classically there are four defects: pulmonary stenosis, narrowing of the exit from the right ventricle a ventricular septal ...
If d-TGA is accompanied by both a VSD and pulmonary stenosis, a systolic murmur will be present. On the rare occasion (when ... This is a less common variant, and with this arrangement, an unusual coronary artery pattern is common. There are also some ... It has as contra-indication coronary anomalies. Since 1981 Lecompte has put his Lecompte manoeuvre in use. This is used with ... The procedure involves transecting both the aorta and pulmonary artery; the coronary arteries are then detached from the aorta ...
Coronary angiography can visualize coronary artery stenosis, or narrowing of the blood vessel. The degree of stenosis can be ... To detect coronary artery disease, a CT scan is more satisfactory than an MRI scan. The sensitivity and specificity between CT ... Any stenoses found may be treated by the use of balloon angioplasty, stenting, or atherectomy. Post mortem CT angiography for ... One of the most common angiograms performed is to visualize the blood in the coronary arteries. A long, thin, flexible tube ...
Recurrence of FPE is thought to be associated with hypertension[18] and may signify renal artery stenosis.[19] Prevention of ... Flash pulmonary edema: association with hypertension and recurrence despite coronary revascularization. Am Heart J. 2000 Sep; ... Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: treatment by angioplasty or surgical ... recurrence is based on managing hypertension, coronary artery disease, renovascular hypertension, and heart failure. ...
"Exercise-induced U-wave inversion as a marker of stenosis of the left anterior descending coronary artery". Circulation. 60 (5 ... "The U wave is the momentum carried by the blood in the coronary arteries and blood vessels".[4][5][6] ... The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... This idea is also proved by the fact that hypertrophy of the left ventricle, myocardial ischemia, coronary and insufficiency ...
Had mitral valve stenosis (shrunk) and regurgitation (leaking) and aortic valve stenosis (shrunk). Had robotic double valve ... Patient had coronary artery disease and severe mitral valve leak. Patient had combined robotic mitral valve replacement and ... Patient had aortic valve stenosis (shrunk) and regurgitation (leak) with reduced pumping of the heart. He underwent robotic ... coronary artery bypass surgery. India's first Robotic Aortic Valve Replacement, 2010. 18-year-old patient with complaints of ...
... coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple ... Overall, this leads to relaxation of the smooth muscle and coronary vasodilation. The effect of nicorandil as a vasodilator is ... Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic ... In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma ...
... is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, ... May 2007). "Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study". J ... June 1996). "Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses". N. Engl. J ... a stenosis relative to the pressure before the stenosis.[citation needed] The result is an absolute number; an FFR of 0.80 ...
Romagnoli E, Niccoli G, Crea F (October 2005). "Images in cardiology: A coronary organic stenosis distal to severe, ergonovine ... It can induce spasm of the coronary arteries. It is used to diagnose variant (Prinzmetal's) angina. Possible side effects ... Sunagawa O, Shinzato Y, Touma T, Tomori M, Fukiyama K (May 2000). "Differences between coronary hyperresponsiveness to ...
They're used to treat bone fractures, osteoarthritis, scoliosis, spinal stenosis, and chronic pain. Examples include a wide ... and coronary stent. Orthopaedic implants help alleviate issues with the bones and joints of the body. ...
"Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. ...
This formula is used to study the severity of aortic valve stenosis and mitral valve stenosis. Gorlin was a very early pioneer ... In addition, he was one of the first to recognize that significant left main coronary artery disease was a dire prognostic ... developed the Gorlin formula used to calculate valve areas in aortic valve stenosis and mitral valve stenosis. Gorlin was born ... He was also one of the first to describe angina pectoris in patients without obstructive coronary artery disease, also now ...
Therefore, IRE has been suggested as preventive treatment for coronary artery re-stenosis after percutaneous coronary ...
"Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute ... However, the idea of coronary artery vasospasm is still believed to contribute to the TTS disease process. The theory of ... The condition is thought to be responsible for 2% of all acute coronary syndrome cases presenting to hospitals. Although TTS ... Zamir, M (2005). The Physics of Coronary Blood Flow. Springer Science and Business Media. p. 387. ISBN 978-0387-25297-1. "Mayo ...
Aortic coarctation and aortic stenosis are both forms of aortic narrowing. In terms of word root meanings, the names are not ... This can be fixed by either another coarctectomy[citation needed]. Coronary artery disease (CAD) is a major issue for patients ... Some children born with coarctation of the aorta have other heart defects too, such as aortic stenosis, ventricular septal ... After a coarctation repair 20-60% of infant patients may experience reoccurring stenosis at the site of the original operation ...
Carotid artery stenosis is a major risk factor for stroke, and risk assessment of atherosclerotic carotid plaques is a critical ... Contraindications to the ultrasound contrast include allergy, heart failure, acute coronary syndrome, endocarditis, ventricular ... B-mode ultrasound is able to assess the structure of the carotid arteries and can identify areas of stenosis. B-mode is used ... It is most often used to diagnose carotid artery stenosis, a form of atherosclerosis, and has the capability to assess plaque ...
In particular in cases when the degree of stenosis of a coronary artery is unclear, IVUS can directly quantify the percentage ... The arteries of the heart (the coronary arteries) are the most frequent imaging target for IVUS. IVUS is used in the coronary ... In the early 1990s, IVUS research on the re-stenosis problem after angioplasty lead to recognition that most of the re-stenosis ... Only 14% of heart attacks occurred at locations with 75% or more stenosis[citation needed], the severe stenoses previously ...
... can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems, or a ... Ventricular tachycardia can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems (e.g., ...
The authors also found that men with carotid stenosis or ischemic heart disease were at greater risk for the progression of ... atherosclerosis . Atherosclerosis can lead to coronary artery disease, carotid artery disease, peripheral artery disease, and ...
Less than 20% of all cases of chest pain admissions are found to be due to coronary artery disease. The rate of chest pain as a ... Aortic stenosis: This condition happens when the person has underlying congenital bicuspid valve, aortic sclerosis, or history ... If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack"): People usually complained of a ...
He described a type of aortic stenosis which was not rheumatic in origin, and described effort syncope in the condition. He ... studied angina pectoris, describing the syndrome in Les Angines de Poitrine in 1925; he maintained the belief that coronary ...
2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ... and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis ...
... such as diverticulitis and acute coronary syndrome.[36][106] Diagnosis of late-stage Lyme disease is often complicated by a ... "Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech ...
... which is associated with lumbar spinal stenosis. It is strongly associated with smoking, hypertension, and diabetes.[2] ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
IHPS2: Pyloric stenosis, infantile hypertrophic, 2. *ITFG3: encoding protein Protein ITFG3. *KDM8: encoding protein Lysine ... CHDS1: Coronary heart disease, susceptibility to, 1. *CIAPIN1: Anamorsin (originally, Cytokine induced apoptosis inhibitor 1) ...
Bilateral renal artery stenosis should always be considered as a differential diagnosis for the presentation of HN. Kidney ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... This leads to a build-up of plaques and they can be deposited in the renal arteries causing stenosis and ischemic kidney ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
... referred to as percutaneous coronary intervention or angioplasty, involves placing a stent at the site of stenosis in an artery ... in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary ... Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. ... L-type calcium channel blockers can induce dilation of the coronary arteries while also decreasing the heart's demand for ...
... tricuspid valve stenosis, pulmonary valve stenosis and aortic valve stenosis. Stenosis of the mitral valve is a common ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... This is a result of the valve becoming thickened and any of the heart valves can be affected, as in mitral valve stenosis, ... For example, valvular disease of the aortic valve, such as aortic stenosis or aortic regurgitation, may cause breathlessness, ...
Coronary perfusion pressures are decreased by these factors, which also increase myocardial oxygen consumption, possibly ... Excessive reduction in blood pressure can precipitate coronary, cerebral, or renal ischemia and, possibly, infarction. ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ... Stenosis. *Carotid artery stenosis. *Renal artery stenosis. Other. *Aortoiliac occlusive disease. *Degos disease ...
Spontaneous coronary artery dissection (SCAD). *කිරීටක ශ්‍යානිය (Coronary thrombosis). *Coronary vasospasm. *Myocardial bridge ...
In men, coronary disease is more frequent, while in women, high systolic blood pressure and valvular heart disease are more ... This includes valvular heart disease (such as mitral stenosis, mitral regurgitation, and tricuspid regurgitation), hypertension ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ... Cardiovascular factors known to be associated with the development of AF include high blood pressure, coronary artery disease, ...
This is known as renovascular hypertension; it is thought that decreased perfusion of renal tissue due to stenosis of a main or ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Voiculescu A, Rump LC (January 2009). "[Hypertension in patients with renal artery stenosis]". Der Internist (in German). 50 (1 ... Kidney disease / renal artery stenosis - the normal physiological response to low blood pressure in the renal arteries is to ...
For this reason the left, right and posterior aortic sinuses are also called left-coronary, right-coronary and non-coronary ... Aortic stenosis. *Aortitis, inflammation of the aorta that can be seen in trauma, infections, and autoimmune disease ... Combination of coronary sinus, superior vena cava and inferior vena cava. Supplies. The systemic circulation. (entire body with ... Right and left coronary arteries.. Arch of aorta (supra-aortic vessels): Brachiocephalic trunk. Left common carotid artery. ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Stenosis. *Carotid artery stenosis. *Renal artery stenosis. Other. *Aortoiliac occlusive disease. *Degos disease ...
... tricuspid valve stenosis, pulmonary valve stenosis and aortic valve stenosis. Stenosis of the mitral valve is a common ... The heart also has a coronary sinus valve, and a inferior vena cava valve, not discussed here. ... This is a result of the valve becoming thickened and any of the heart valves can be affected, as in mitral valve stenosis, ... For example, valvular disease of the aortic valve, such as aortic stenosis or aortic regurgitation, may cause breathlessness, ...
They are used to diagnose and monitor esophageal reflux, dysphagia, hiatus hernia, strictures, diverticula, pyloric stenosis, ... and stenosis in Barium X-rays.[26] Anisakiasis is demonstrated by Barium X-rays as bowel wall oedema, thickening, ulceration, ... Coronary *Calcium scan. *CT angiography. *Abdominal and pelvic CT *Virtual colonoscopy. *CT angiography *Coronary CT ...
venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... Mitral stenosis is a narrowing of the valve. This can be heard as an opening snap in a heart sound which is not normally ... mitral stenosis). Rheumatic heart disease often affects the mitral valve; the valve may also prolapse with age and be affected ... of inferior vena cava, valve of coronary sinus) → tricuspid valve → right ventricle (infundibulum, moderator band/septomarginal ...
Left coronary artery, right coronary artery and continues as the aortic arch. ... Van Mieghem, Nicolas M.; Van Der Boon, Robert M.A. (2013). "Porcelain Aorta and Severe Aortic Stenosis: Is Transcatheter Aortic ... Combination of superior and inferior vena cava and coronary sinus. Supplies. The entire body, with exception of the respiratory ... The only branches of the ascending aorta are the two coronary arteries which supply the heart; they arise near the commencement ...
"Aortic Stenosis: Overview - eMedicine Emergency Medicine". Retrieved 2009-02-28.. *^ Redington AN, Gray HH, Hodson ME, Rigby ML ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... "Prediction of left ventricular pressure in infants with aortic stenosis". British Heart Journal. 44 (4): 406-10. doi:10.1136/ ... of inferior vena cava, valve of coronary sinus) → tricuspid valve → right ventricle (infundibulum, moderator band/septomarginal ...
Echocardiography is an essential tool in cardiology, assisting in evaluation of heart valve function, such as stenosis or ... Intravascular ultrasound image of a coronary artery (left), with color-coding on the right, delineating the lumen (yellow), ... This is particularly important in neurology, where ultrasound is used for assessing blood flow and stenoses in the carotid ... stenosis, vasospasm from a subarachnoid hemorrhage (bleeding from a ruptured aneurysm), and other problems. ...
Coronary stents are placed during a coronary angioplasty. The most common use for coronary stents is in the coronary arteries, ... Stent grafts are also used to treat stenoses in vascular grafts and fistulas used for hemodialysis. ... The first use of a coronary stent is typically attributed to Jacques Puel [fr] and Ulrich Sigwart when they implanted a stent ... There is a wide variety of stents used for different purposes, from expandable coronary, vascular and biliary stents, to simple ...
Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and the autosomal dominant cutis ... "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448-54. doi:10.1161 ... "The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis". Cell. 73 (1): 159-168. doi ... and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis ...
Foster, B. J. (2000-09-01). «Kawasaki disease complicated by renal artery stenosis» Archives of Disease in Childhood 83 (3): ... Radford, Dorothy J.. (1976-06-01). «Mucocutaneous Lymph Node Syndrome With Coronary Artery Aneurysm» Archives of Pediatrics & ...
Mechanical: vascular injury, pneumothorax (by placing pulmonary artery catheter), tracheal injury/stenosis (result of ... Coronary care unit (CCU). *Critical illness insurance. Conditions. Organ system failure. Shock sequence. SIRS. Sepsis. Severe ...
Congenital/acquired pulmonary venous stenosis. WHO Group III - Pulmonary hypertension due to lung disease, chronic hypoxia ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ...
"Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease. The ... Pyloric stenosis. *Achlorhydria. *Gastroparesis. *Gastroptosis. *Portal hypertensive gastropathy. *Gastric antral vascular ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
... especially coronary artery bypass graft, where there are significant fluctuations in the blood pressure), disturbances in blood ... Stenosis. *Carotid artery stenosis. *Renal artery stenosis. Other. *Aortoiliac occlusive disease. *Degos disease ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
There are many different methods to grade the degree of stenosis, including visual assessment; manually determined diameter or ... How is stenosis graded using coronary computed tomography angiography (CCTA)?) and How is stenosis graded using coronary ... Drugs & Diseases , Clinical Procedures , Coronary CT Angiography Q&A How is stenosis graded using coronary computed tomography ... The diagnostic performance of coronary CT angiography for the assessment of coronary stenosis in calcified plaque. PLoS One. ...
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Dynamic mechanisms in human coronary stenosis.. B G Brown, E L Bolson, H T Dodge ... At the clinical level, coronary stenoses frequently behave as though the obstruction to flow were variable and not as rigidly ... This extremely important morphologic feature of stenoses permits transient variation in stenosis lumen diameter in response to ... many of the clinical features of coronary disease and its pharmacologic responses are explained in terms of these stenosis ...
"Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional coronary ... O. F. Donati, P. Stolzmann, L. Desbiolles et al., "Coronary artery disease: which degree of coronary artery stenosis is ... with the same stenosis length of 4 mm. To investigate the effect of stenosis location, a 4 mm length stenosis with DS of 55% ... DS cannot characterize hemodynamic functional significance of coronary stenosis on myocardial blood supply. Among the stenoses ...
coronary artery disorder coronary occlusion coronary artery disease coronary artery function entire coronary artery renal ... coronary arteries anatomy balloon angioplasty coronary angiography coronary artery distribution coronary artery bypass surgery ... Sex Makes No Difference in Coronary CT. diagnosing coronary artery disease in women thats... identify coronary stenosis ... coronary arteries be regarded as organs at risk in... lower odds of coronary artery stenosis for women... ...
coronary artery bypass graft coronary artery stenosis coronary artery disease vascular graft stenosis coronary occlusion artery ... coronary ostium stenosis percutaneous coronary intervention coronary arteriosclerosis cabg coronary graft occluded main disease ... identify coronary stenosis greater than 50 percent was... imaging to detect coronary stenosis in patients without... ... ANGELES - Coronary artery bypass grafting (CABG)... stenosis in two or more major coronary vessels (83 percent... ...
... with 55 coronary stenoses of at least 50% underwent coronary CT angiography (one stenosis in 13 patients, two stenoses in 15 ... 29 of 30 stenoses), 96% (23 of 24 stenoses), 97% (29 of 30 stenoses), 96% (23 of 24 stenoses), and 96% (52 of 54 stenoses), ... Diagnosis of functionally significant coronary stenosis with exercise CT myocardial perfusion imaging.. Habis M1, Ghostine S, ... in patients suspected of having hemodynamically significant coronary stenosis.. MATERIALS AND METHODS: This study had ...
Coronary Artery Disease Coronary Stenosis Angina, Unstable Angina, Stable Diagnostic Test: iFR pullback ... Coronary Artery Disease. Angina Pectoris. Coronary Stenosis. Angina, Unstable. Angina, Stable. Constriction, Pathologic. ... Physiologic Assessment of Coronary Stenosis Following PCI (DEFINE PCI). The safety and scientific validity of this study is the ... Focal stenosis [ Time Frame: 12 month ]. Proportion of cases in which the iFR would become non-significant if a focal stenosis ...
... Lei Xu,1 Zhonghua Sun,2 and Zhanming Fan1 ... Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease ... CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the ... CCTA has emerged as a noninvasive method for the assessment of both anatomy of coronary lesions and its physiological ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Gene context of Coronary Stenosis. *No difference in the score of coronary stenosis index (CSI) was found in FH with/without ... Disease relevance of Coronary Stenosis. *Glucose metabolism distal to a critical coronary stenosis in a canine model of low- ... Chemical compound and disease context of Coronary Stenosis. *Coronary stenosis dilatation induced by L-arginine [11]. ... Coronary vasomotor effects of serotonin in patients with angina. Relation to coronary stenosis morphology. Tousoulis, D., ...
Elective stenting of carotid artery stenosis in patients with severe coronary artery disease.. Waigand J1, Gross CM, Uhlich F, ... All patients had severe coronary artery disease, and/or mitral insufficiency, aortic stenosis, rhythm disorders or generalized ... In three patients the opposite carotid artery was occluded; nine patients had bilateral stenoses of which two received stents ... the feasibility and safety of elective carotid stent implantation in patients with carotid stenoses and concomitant coronary ...
Coronary artery disease. cerebral artery stenosis. percutaneous coronary balloon angioplasty. coronary artery bypass surgery. ... Coronary artery stenosis ,50% and either carotid or brain artery stenosis , 50% ... Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia. The safety and scientific validity of this study is the ... There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had ...
Dr Manisha Lakhekar presents a case diagnosed as moderate stenosis at midright coronary artery. Aconite, Arsenicum and Rhus tox ... Minimal stenosis(,25%) at proximal LCX.. What is Stenosis?Coronary artery stenosis is a heart disease that mainly occurs due to ... Mitral Stenosis Information about mitral stenosis symptoms, causes, mitral stenosis treatment or management with homeopathy ... Dr Manisha Lakhekar presents a case diagnosed as moderate stenosis at midright coronary artery. Aconite, Arsenicum and Rhus tox ...
A 23-year-old man with a 2-year history of worsening sinusitis and asthma presented with acute ischaemic type chest pain. A 12-lead ECG had 0.5 mm ST elevation in lead III and 0.5 mm ST depression in leads I and aVL. Chest pain resolved with sublingual nitrates. He was commenced on antiplatelet therapy and referred … ...
demonstrated in a small study that a very high coronary calcium score is a predictor of severe coronary stenosis in patients ... and right coronary artery (RCA). Severe left main coronary artery disease (LMCAD) was defined as ,50% diameter stenosis [9]. ... both with severe coronary stenosis.. Table 1 Comparison between severe and non-severe coronary artery disease, as assessed by ... Functional measurement of coronary stenosis. J Am Coll Cardiol. 2012;59:1045-57.CrossRefPubMedGoogle Scholar ...
... June 13th, 2014 Medgadget Editors Cardiology, Radiology ... The Chocolate PTCA is indicated for dilation of the coronary artery or bypass graft stenosis for improving myocardial perfusion ... The device is very much based on the companys Chocolate PTA balloon catheter, a product designed to address stenosis in the ... was designed with similar engineering principles and is aimed to provide predictable and uniform dilatation of the coronary ...
The test offers an alternative to diagnostic catheterization to grade the severity of coronary artery disease, according to a ... Quantitative myocardial first-pass perfusion can distinguish coronary artery stenoses with a high degree of specificity and ... The sensitivity, specificity, PPV, and NPV for MR imaging to detect severe stenosis as determined visually from coronary ... Quantitative myocardial first-pass perfusion can distinguish coronary artery stenoses with a high degree of specificity and ...
... grading and classifying coronary stenoses in CCTA caused by all types of plaques. We propose a four-step approach including a ... This has lead to the development of several algorithms for automatic detection and grading of coronary stenoses. However, most ... Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable ... alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). ...
... of the left main coronary artery underwent aortocoronary bypass. Intra-aortic balloon counterpulsation was used preoperatively ... Over a 2-year period 33 patients with symptomatic stenosis (greater than 75%) ... The authors conclude that aortocoronary bypass surgery for severe stenosis of the left main coronary artery can be safely ... Over a 2-year period 33 patients with symptomatic stenosis (greater than 75%) of the left main coronary artery underwent ...
... Han-Wei Wang, Ji-Xin Cheng, ... Han-Wei Wang, Ji-Xin Cheng, Michael Sturek, Vlad V. Simianu, Matthew J. Locker, "Stent-induced coronary artery stenosis ... Schematic of coronary stent deployment and sample collection. (a) Schematic drawing of coronary arteries and the study design ... For the analysis of the collagen expression in the stented coronaries, SFG images of the stented coronaries were quantitatively ...
Coronary Stenosis ongoing clinical trials report provides comprehensive analysis and trends in global Coronary Stenosis disease ... 3.1 Ongoing Coronary Stenosis Trials by Phase. 3.2 Ongoing Coronary Stenosis Trials by Type. 3.3 Ongoing Coronary Stenosis ... 7.1 Ongoing Coronary Stenosis Trials- Phase 1. 7.2 Ongoing Coronary Stenosis Trials- Phase 2. 7.3 Ongoing Coronary Stenosis ... Coronary Stenosis- Enrolment by Phase, 2018. Figure 8: Coronary Stenosis- Enrolment by Trial Type, 2018. Figure 9: Coronary ...
Physiological Assessment of Coronary Stenoses and the Microcirculation (9781447152446) and a great selection of similar New, ... 2. Physiological Assessment of Coronary Stenoses and the Microcirculation (Hardback) Published by Springer London Ltd, United ... 3. Physiological Assessment of Coronary Stenoses and the Microcirculation (Hardback) Published by Springer London Ltd, United ... 6. Physiological Assessment of Coronary Stenoses and the Microcirculation Published by Springer (2017) ...
... continues to develop as a non-invasive method for the assessment of coronary vessel geometry and the ident... ... Summary of "Precise Measurement of Coronary Stenosis Diameter with CCTA Using CT Number Calibration.". Coronary x-ray computed ... In patients with stable coronary artery disease, the amount of myocardium subtended by coronary stenoses constitutes a major ... Coronary Aneurysm. Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to ...
Keywords: Angiography, Constriction, Pathologic, Coronary Artery Disease, Coronary Stenosis, Fractional Flow Reserve, ... Coronary Flow Reserve and Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis. J Am Coll Cardiol 2016; ... YOU ARE HERE: Home , Latest in Cardiology , Coronary Flow Reserve and Intermediate Stenosis ... What are the implications of coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) in patients with ...
For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial ... Participants, who had 55 coronary stenoses of at least 50%, underwent coronary CT angiography. Within one minute after ... Exercise Perfusion CT Imaging IDs Coronary Stenosis. This article originally appeared here. ... HealthDay News) - For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography ...
Is left main coronary artery stenosis a risk factor for early mortality in coronary artery surgery? J Card Surg 2000;15:217-22. ... Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary ... Assessing the risk of waiting for coronary artery bypass graft surgery among patients with stenosis of the left main coronary ... Should patients with stenosis of the left main coronary artery waiting for bypass grafting be given priority?. Helena Rexius ...
Multi-scale feature extraction for learning-based classification of coronary artery stenosis Author(s): Matthias Tessmann; ... Moreover, lesion based evaluation revealed that the majority of stenosis can be reliable identified in terms of position, type ... Subsequently, the resulting strong classification function is used in order to detect different types of coronary lesions in ... Assessment of computed tomography coronary angiograms for diagnostic purposes is a mostly manual, timeconsuming task demanding ...
... J ... Seven dogs had an iatrogenic critical stenosis of their left anterior descending coronary artery (experimental group); seven ... Objective: Limited cardiac reserve, secondary to coronary disease, may be associated with end organ morbidity. In this study, ... and ischemic colitis in critically ill patients with coronary artery disease. ...
The focal stenosis was simulated by a stainless steel tube (ID ≤ 1.20 mm). Stent expansion was performed using a proprietary ... None of the stent systems failed under the extremely high stress at the edges of the focal stenosis. ... experimental in vitro approach was designed to assess the expansion behavior of stent systems in a resistant focal stenosis ... Expansion characteristics of coronary stents in focal stenoses by Schmidt, Wolfram/ Schmitz, Klaus-Peter/ Behrens, Peter/ ...
  • How is stenosis graded using coronary computed tomography angiography (CCTA)? (
  • Dodd et al found that the cross-sectional area technique had the highest correlation with quantitative coronary angiography, and MIP technique had the smallest interobserver variability. (
  • Prospectively gated axial CT coronary angiography: comparison of image quality and effective radiation dose between 64- and 256-slice CT. (
  • Prospectively gated transverse coronary CT angiography versus retrospectively gated helical technique: improved image quality and reduced radiation dose. (
  • Kroft LJ, de Roos A, Geleijns J. Artifacts in ECG-synchronized MDCT coronary angiography. (
  • Decramer I, Vanhoenacker PK, Sarno G, Van Hoe L, Bladt O, Wijns W. Effects of sublingual nitroglycerin on coronary lumen diameter and number of visualized septal branches on 64-MDCT angiography. (
  • Visualization techniques in computed tomographic coronary angiography. (
  • Visual and automatic grading of coronary artery stenoses with 64-slice CT angiography in reference to invasive angiography. (
  • Thirty-two consecutive patients (26 men [mean age, 63 years] and six women [mean age, 71 years]) with 55 coronary stenoses of at least 50% underwent coronary CT angiography (one stenosis in 13 patients, two stenoses in 15 patients, and three stenoses in four patients). (
  • Fractional flow reserve less than 0.8, as measured during invasive coronary angiography, was the reference for defining significant stenoses. (
  • This is a pilot study designed to assess the relationship between iFR pullback and the distribution of coronary atheroma/stenoses as assessed by Quantitative Coronary Angiography (QCA) post angiographically successful PCI. (
  • Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). (
  • We evaluated predictors for severe stenosis at invasive angiography in patients with persisting symptoms after normal MPI. (
  • Increasing age, male gender, previous PCI and typical symptoms are predictors of severe stenosis at invasive coronary angiography in patients with normal MPI. (
  • Since invasive coronary angiography (ICA) is still the gold standard for ruling out obstructive coronary disease, it can be considered in patients with normal MPI with persisting symptoms. (
  • Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). (
  • The PON1-Arg-192 genotypes were detected by PCR-RFLP in 414 individuals undergoing their first coronary angiography. (
  • Since the introduction of coronary angiography, a key technique in understanding coronary artery disease, a number of paradigms regarding its study and interpretation have taken place. (
  • angiography (CCTA) continues to develop as a non-invasive method for the assessment of coronary vessel geometry and the identification of physiologically significant lesions. (
  • Biomarkers and their relative contributions to identifying coronary artery stenosis based on coronary computed tomography angiography in asymptomatic adults. (
  • Coronary computed tomography angiography (CCTA) has emerged as an important, non-invasive imaging modality for the assessment of coronary vascular disease. (
  • Invasive coronary angiography findings across the CAD-RADS classification spectrum. (
  • Coronary CT angiography by modifying tube voltage and contrast medium concentration: Evaluation of image quality and radiation dose. (
  • Currently, there is an increasing interest in noninvasive imaging of cardiovascular system such as computed tomography coronary angiography (CCTA). (
  • The Invictus Registry will compare the diagnostic performance of coronary computed tomography angiography (CCTA) versus intravascular imaging by intravenous ultrasound (IVUS) or optical co. (
  • Computed Tomography Derived Fractional Flow Reserve (CT-FFR) is a noninvasive method for evaluating the hemodynamic significance of coronary artery lesions by using coronary CT Angiography. (
  • Coronary calcium hampers accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). (
  • Participants, who had 55 coronary stenoses of at least 50%, underwent coronary CT angiography. (
  • We aimed to determine the incidence of coronary artery stenosis (CAS) in asymptomatic FH patients using coronary computed tomography angiography (CCTA). (
  • Coronary angiography was undertaken at a variable period after the index event in each study. (
  • 572 consecutive patients in a Coronary Care Unit who underwent angiography following diagnosis of NSTEMI. (
  • and to investigate whether presence of UMI is associated with stenotic lesions in the coronary artery supplying the segment of the myocardium in which the UMI is located, using coronary angiography to determine the individual coronary anatomy in each patient. (
  • In this prospective multicenter study, we included patients with stable angina pectoris and without prior myocardial infarction, scheduled for coronary angiography. (
  • A LGE CMR examination was performed prior to the coronary angiography. (
  • This study was performed to determine the prevalence and to identify the predictors of RAS in hypertensive patients undergoing coronary artery angiography. (
  • In a cross-sectional study from August 2008 to August 2009, 481 patients with HTN and suspected CAD underwent selective coronary and renal angiography for screening and predicting RAS. (
  • Contrast angiography is a standard method for the detection of RAS that is readily performed in combination with coronary angiography [ 8 ]. (
  • Therefore, using abdominal aortography concomitant with coronary angiography, a close relationship between the extent of CAD and the severity of RAS has been confirmed [ 9 ][ 10 ]. (
  • Assessment of Coronary Stenoses Using Coronary CT-angiography and Non-invasive Fractional Flow Reserve Measurement. (
  • FFR Derived From Coronary CT Angiography in Nonculprit Lesions of Patients With Recent STEMI. (
  • We compared a new computer-enhanced, resting ECG analysis device, 3DMP, to coronary angiography to evaluate the device's accuracy in detecting hemodynamically relevant CAD. (
  • A convenience sample of 172 patients with a history of coronary revascularization scheduled for coronary angiography was evaluated with 3DMP before coronary angiography. (
  • 3DMP's sensitivity and specificity in detecting hemodynamically relevant coronary stenosis as diagnosed with coronary angiography were calculated as well as odds ratios for the 3DMP severity score and coronary artery disease risk factors. (
  • Coronary angiography remains the gold standard for the morphologic diagnosis of CAD and also allows revascularization during the same procedure [ 5 , 6 ]. (
  • We sought to determine the diagnostic accuracy of noninvasive qualitative (computed tomography coronary angiography [CTCA]) and quantitative computed tomography coronary angiography (QCT) to predict the hemodynamic significance of a coronary stenosis, using intracoronary fractional flow reserve (FFR) as the reference standard. (
  • CTCA and conventional coronary angiography (CCA), and QCT and quantitative coronary angiography (QCA), were performed to determine the severity of a stenosis that was compared with FFR measurements. (
  • Invasive coronary angiography (ICA) has been the gold standard in the diagnosis of coronary artery disease (CAD) for a long time and angiographic procedures performed annually in the United States have steadily increased during the last 25 years. (
  • The unmatched temporal and spatial imaging resolution, the high level contrast between the coronary lumen and the adjacent structures, and the ability to concurrently perform percutaneous coronary interventions (PCI) are the technical advantages of coronary angiography. (
  • Only three cases of coronary artery disease related to sorafenib therapy have been described in the literature, and all were due to arterial vasospasm without evidence of coronary artery stenosis on angiography. (
  • A 58-year-old man with mRCC developed acute coronary syndrome (ischemia/infarction) associated with critical sub-occlusion of the common trunk of the left coronary artery and some of its branches, which was documented on coronary angiography. (
  • All three cases were associated with the presence of cardiovascular risk factors and were due to arterial vasospasm without evidence of coronary artery stenosis on angiography [ 9 - 11 ]. (
  • In 17 patients who were past chronic cigarette smokers, cross-sectional areas of 32 coronary artery stenoses and 32 adjacent apparently normal segments were measured by using quantitative coronary angiography at baseline and after a cold pressor test before and after nicotine gum chewing. (
  • Vasodilator-stress CT perfusion imaging in addition to CT coronary angiography (CTCA) may provide a single-test alternative to nuclear stress testing, commonly used to assess hemodynamic significance of stenosis. (
  • Percutaneous coronary interventions (PCI) guided by physiological assessment using fractional flow reserve (FFR) have been shown to reduce cardiovascular events when compared to angiography alone. (
  • We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography. (
  • Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. (
  • Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. (
  • We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other. (
  • Selective coronary angiography delineated an isolated long-segment stenosis of the left brainstem coronary artery with no other lesions. (
  • Interobserver variability in coronary angiography. (
  • This study aims to examine quantitative optical coherence tomography (OCT) derived measurements intermediate coronary stenosis from quantitative coronary angiography (QCA). (
  • Methods 240 patients with coronary intermediate stenosis by quantitative coronary angiography (QCA) and underwent OCT assessment of the lesions artery. (
  • Cardiac catheterization and selective coronary angiography showed evidence of an anterolateral myocardial infarction and that there was no coronary ostial stenosis, but total occlusion of the left anterior descending coronary artery (LAD) proximally with retrograde filling from the right coronary artery was revealed. (
  • Video 10-13: Coronary angiography revealing high-grade stenosis in the proximal right coronary artery. (
  • Semi-quantitative stenosis assessment by coronary CT angiography only modestly predicts stress-induced myocardial perfusion abnormalities. (
  • CorE-64 is a multicenter, international study to assess the accuracy of 64-slice QCTA for detecting ±50% coronary arterial stenoses by quantitative coronary angiography (QCA). (
  • Confounding variables affecting the relationship between coronary anatomy and myocardial perfusion likely account for some of the observed discrepancies between coronary angiography and SPECT results. (
  • In most cases, only 0.13% to 0.8 % patients undergo coronary angiography. (
  • Repeated angiography would show the coroostial ostial stenosis in the patients. (
  • We performed angiography and quantitative vessel analysis of the coronary arteries, bilateral common and internal iliac arteries, and internal pudendal arteries (IPAs). (
  • He underwent coronary angiography for vessel CAD, and PTCAs and stanting were performed. (
  • At the time of the initial episode, coronary angiography revealed no substantial stenosis. (
  • As the most common type of cardiovascular disease, coronary artery disease (CAD) is caused by the build-up of plaques on the endothelial walls of coronary arteries, which leads to a reduction in arteries cross-sectional area and blood supply to the myocardium [ 1 ]. (
  • coronary arteries be regarded as organs at risk in. (
  • People with a buildup of plaque in their arteries have coronary heart disease, a major risk factor for heart attacks. (
  • heart in people who have coronary arteries . (
  • 70%, stenoses in 53 carotid arteries with balloon angioplasty followed by elective stent implantation. (
  • We demonstrate for the first time the applicability of multimodal nonlinear optical (NLO) microscopy to the interrogation of stented coronary arteries under different diet and stent deployment conditions. (
  • Bare metal stents and Taxus drug-eluting stents (DES) were placed in coronary arteries of Ossabaw pigs of control and atherogenic diet groups. (
  • The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES. (
  • Participants were divided according to the number of stenotic coronary arteries (patent, one-, two-and three-vessel disease). (
  • Also we found that PTX3 levels and Calcium Scores differed among individuals with triple-vessel involvement and individuals without significant stenosis in any of coronary arteries. (
  • Conclusion: PTX3 levels in periphery correlate with those in coronary arteries, and this variable can be measured with a less invasive procedure. (
  • According to angiographic data, 425 patients (88.4%) had CAD, while 56 (11.6%) had normal coronary arteries. (
  • Revascularization of coronary arteries is one of the most frequently performed medical interventions in the developed world. (
  • The purpose of this study was to examine the short-term effects of nicotine gum chewing on the dimensions of coronary arteries of patients with coronary artery disease and on the response of coronary vessels to sympathetic stimulation caused by the cold pressor test. (
  • Arterioles (≈200-μm passive inner diameter at 60 mm Hg) were isolated from regions perfused by the stenotic left anterior descending and normal left circumflex coronary arteries and studied in vitro. (
  • Fused 3D displays of subendocardial X-ray attenuation with coronary arteries were created to detect stress perfusion defects (SPD) in each coronary territory. (
  • 50% stenosis in 31/224 arteries. (
  • The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. (
  • The reporting system of representing stenosis area on the coronary arteries is developed. (
  • The coronary arteries were examined in 60 specimens from patients with mitral stenosis. (
  • This transmits blood around any lessened coronary arteries. (
  • Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. (
  • In coronary artery bypass grafting/surgery (CABG), new arteries are created in order to provide blood to the heart using other blood ves sels as conduits to bypass the blocked section in the patient's coronary arteries. (
  • Coronary flow reserve (CFR) is the maximum increase in blood flow through the coronary arteries above the normal resting volume. (
  • Its measurement is often used in medicine to assist in the treatment of conditions affecting the coronary arteries and to determine the efficacy of treatments used. (
  • When demand for oxygen in the myocardium is increased, the vascular resistance of the coronary arteries has the ability to reduce, and this can increase the volume of blood passing through the blood vessels. (
  • Although our understanding is incomplete, many of the clinical features of coronary disease and its pharmacologic responses are explained in terms of these stenosis properties and their interaction. (
  • Coronary Artery Disease (CAD). (
  • diagnosing coronary artery disease in women that's. (
  • disease (CHD), or coronary artery disease. (
  • 800,000 from coronary artery disease. (
  • likely to suffer from coronary artery disease. (
  • support the heart, detect coronary artery disease. (
  • Elective stenting of carotid artery stenosis in patients with severe coronary artery disease. (
  • To evaluate the feasibility and safety of elective carotid stent implantation in patients with carotid stenoses and concomitant coronary artery disease, as an alternative to combined carotid and coronary surgery. (
  • All patients had severe coronary artery disease, and/or mitral insufficiency, aortic stenosis, rhythm disorders or generalized arteriosclerosis. (
  • Our preliminary results indicate that carotid artery stenting in patients with concomitant severe coronary artery disease is feasible, safe, and may be an alternative to combined carotid and coronary surgery. (
  • There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass surgery (CABG) or percutaneous coronary intervention. (
  • Coronary artery stenosis is a heart disease that mainly occurs due to the narrowing of the artery and could result in major heart problems. (
  • Severe stenosis was observed in 34%, and of these patients 60% had single-vessel disease (not left main coronary artery disease). (
  • The test offers an alternative to diagnostic catheterization to grade the severity of coronary artery disease, according to a presentation at the North American Society of Cardiac Imaging meeting. (
  • Regarded as an iatrogenic disease, in-stent restenosis is a complex response after coronary stenting 1 and still remains a clinical problem. (
  • The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. (
  • The aim of the present study was to evaluate whether the PON1 gene polymorphism is an independent risk factor for severity of coronary artery disease in patients from west of Iran. (
  • Kharrazi H, Vaisi-Raygani A, Sabokroh AR, Pourmotabbed T (2006) Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. (
  • Vaisi-Raygani A, Rahimi Z, Nomani H, Tavilani H, Pourmotabbed T (2007) The presence of apolipoprotein ε4 and ε2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. (
  • Vaisi Raygani A, Rahimi Z, Tavilani H, Pourmotabbed T (2010) Butyrylcholinesterase K variant and the APOE-ε4 allele work in synergy to increase the risk of coronary artery disease especially in diabetic patients. (
  • Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A (2007) Prevalence of coronary artery disease risk factors in Iran: a population based survey. (
  • Following an emphasis on improved angiographic and subsequent intracoronary imaging techniques, functional assessment of coronary circulation has demonstrated to have major implications for diagnosis and treatment of coronary artery disease. (
  • This is particularly noticeable in the assessment of microcirculation, an unavoidable compartment of coronary circulation that is frequently affected in acute coronary syndromes of in the presence of cardiovascular risk factors or non-coronary heart disease. (
  • This book aims to be an indispensable tool for clinicians and researches in the field of coronary artery disease. (
  • It provides a balanced, comprehensive review of anatomy, physiology and available techniques, discusses both the diagnosis of epicardial vessel and microcirculatory disease, the impact of different diseases at different levels of coronary circulation, and the best way to address a separate or combined assessment of different levels of coronary circulation. (
  • the ESC International Summit on Coronary Microcirculation and Heart Disease. (
  • The recently introduced coronary artery disease reporting and data system (CAD-RADS) evaluated by computed tomography and based on stenosis severity, might not adequately reflect the complexity of CAD. (
  • In patients with stable coronary artery disease, the amount of myocardium subtended by coronary stenoses constitutes a major determinant of prognosis, as well as of the benefit of coronary revasculari. (
  • Coronary Computed Tomography Angiogram (CCTA) is a non-invasive imaging modality that has high sensitivity and negative predictive value for the detection of coronary artery disease (CAD). (
  • The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease refe. (
  • Angina symptoms, cardiac function and extent of coronary artery disease have traditionally been used to allocate patients to groups with different waiting times. (
  • Familial hypercholesterolemia (FH) is associated with premature coronary arterial disease. (
  • We enrolled consecutively, 31 FH patients without symptoms of coronary artery disease. (
  • Limited cardiac reserve, secondary to coronary disease, may be associated with end organ morbidity. (
  • These observations may further our understanding of the pathogenesis of cholecystitis, gastric stress ulcers, ileal endotoxin translocation, and ischemic colitis in critically ill patients with coronary artery disease. (
  • A Prospective, Observational, Non-randomized European, Multi-center Registry Collecting Real Life Information for the Utilization of Instantaneous Wave Free Ratio in Assessing Coronary Stenosis Relevance in the Multi-vessel Disease Patients Population. (
  • Patients enrolled into this prospective registry will be derived from Stable Coronary Artery disease or Acute Coronary Syndrome (ACS) population undergoing cardiac catheterization. (
  • exp ST segment elevation/OR exp ST segment elevation myocardial infarction/OR exp Angina, Unstable/OR exp Percutaneous Coronary Intervention/OR exp Acute Coronary Syndrome/OR exp heart infarction/OR exp Coronary Artery Disease/OR exp Myocardial Infarction/) AND ( (
  • Objective: Coronary Artery Disease (CAD) would continue to concern medical society in the foreseeable future. (
  • A previous study has shown an increased prevalence of late gadolinium enhancement cardiovascular magnetic resonance (LGE CMR) detected unrecognized myocardial infarction (UMI) with increasing extent and severity of coronary artery disease. (
  • However, the coronary artery disease was evaluated on a patient level assuming normal coronary anatomy. (
  • Renal artery stenosis (RAS) has been increasingly recognized in the recent years, especially in patients with coronary artery disease (CAD). (
  • Studies have demonstrated that coronary artery disease (CAD) is one of the most important causes of death in patients with atherosclerotic RAS. (
  • We studied 35 patients with single-vessel coronary artery disease and normal left ventricular function and 21 age-matched controls. (
  • Resting electrocardiogram (ECG) shows limited sensitivity and specificity for the detection of coronary artery disease (CAD), where patients with a history of coronary revascularization may pose special challenges. (
  • Coronary artery disease (CAD) is the leading single cause of death in the developed world. (
  • Cardiotoxicity is commonly associated with the presence of cardiovascular risk factors, such as a history of hypertension or coronary artery disease. (
  • Several authors have concluded that LVEF dysfunction and/or CHF is more frequent in patients with a history of hypertension or coronary artery disease. (
  • Only three cases of coronary artery disease related to sorafenib treatment have been described in the literature. (
  • In 2007, a 58-year-old white male with no history of tobacco use, hypertension, diabetes, or hypercholesterolemia, and no family history of coronary artery disease, was found to have a large solid right renal mass and associated tumor thrombus of the inferior vena cava and right atrium. (
  • The presence of coronary artery disease (CAD) in patients who underwent transcatheter aortic valve implantation (TAVI) may increase in-hospital and long-term mortality. (
  • We identified 1,707 patients who had CABG for LMS stenosis between February 1996 and December 2009, and compared their clinical characteristics and outcomes with a contemporaneous group of 6,260 people with non-LMS disease. (
  • In conclusion, CABG yields good early and late survival benefit for LMS stenosis (protected and unprotected), although operative result is adversely affected by LMS disease. (
  • Severe aortic stenosis (SAS) and severe coronary artery disease (SCAD) are the most frequent reasons to perform cardiac surgery in octogenarians. (
  • Non-coronary vascular disease is frequently present in these patients. (
  • The optimal revascularization technique in patients with left main coronary artery disease (CAD) remains controversial. (
  • Coronary circulation: Pressure/flow parameters for assessment of ischemic heart disease. (
  • Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease. (
  • New Mathematical Correction Model in Pursuit of Optimal Hemodynamic Assessment of Serial Coronary Artery Disease: Overcoming Hyperemic Cross Talk Between Coronary Stenoses in Series? (
  • After the first year of transplantation, allograft coronary artery disease (ACAD) is the second main cause of death. (
  • Reference to earlier literature on coronary atherosclerosis confirms that this histological picture is in keeping with the early phase of this disease. (
  • Patients referred for cardiac catheterization with suspected or known coronary artery disease were enrolled. (
  • It may be concluded that, on the average, the distribution of lesions in patients with mitral stenosis and significant coronary atherosclerosis is less wide than in subjects with clinical coronary disease. (
  • Recent studies show that coronary microcirculatory impairment is an independent predictor of poor outcomes in patients with cardiovascular disease. (
  • Heredity is also a reason in getting coronary artery stenosis , people may suffers by this disease inherently. (
  • Living an inactive life style may result in high danger of such coronary disease. (
  • The disease involves risk and shows adverse affect in left main coronary stenosis , in patients. (
  • Coronary arterial stenosis causes impairment of cardiac function and is the major contributor of mortality in cardiovascular disease. (
  • Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). (
  • In the nine patients with IPA disease, the average stenosis severity was 55 ± 31% (right) and 66% ± 25% (left), and average lesion length was 12.4 ± 5.2 mm (right) and 10.0 ± 3.5 mm (left). (
  • Aortic stenosis is the most important cardiac valve disease in developed countries, affecting 3 percent of persons older than 65 years. (
  • Serial Doppler echo-cardiography is recommended annually for severe aortic stenosis, every one or two years for moderate disease, and every three to five years for mild disease. (
  • Many patients with asymptomatic aortic stenosis have concurrent cardiac conditions, such as hypertension, atrial fibrillation, and coronary artery disease, which should also be carefully managed. (
  • Aspirin prophylaxis should be considered in adults with a 10-year risk of cardiovascular disease of 6 percent or greater, which is common with aortic stenosis. (
  • Existing criteria for the diagnosis of takotsubo cardiomyopathy include the absence of obstructive coronary artery disease. (
  • Although this report is of a single patient only, it definitively illustrates that severe coronary artery disease can occur in patients who have takotsubo cardiomyopathy. (
  • We recommend the thorough evaluation of possible coronary artery disease in high-risk patients, even upon the strong clinical suspicion of takotsubo cardiomyopathy. (
  • Coronary flow reserve is used in diagnostics and treatment of patients suffering from conditions such as coronary artery disease and syndrome X. In the treatment of these conditions, vasodilators are used to allow sufficient blood to flow past a stenosis, for example, and the measurement of CFR enables the efficacy of such interventions to be measured. (
  • Atherosclerosis Peripheral artery disease Peripheral vascular disease Stenosis Systemic circulation Thrombosis "What Is Peripheral Vascular Disease? (
  • Diameter stenosis (DS) is commonly applied to quantify the anatomic severity of CAD. (
  • Fractional flow reserve, a pressure derived index of stenosis severity, constitutes the best example of the current importance of physiological assessment in clinical practice. (
  • Percentage of stenosis properly classified by iFR® in terms of hemodynamic severity compare to FFR in MVD patients. (
  • Basal flow was unchanged regardless of the severity of stenosis, expressed as a percentage of the diameter of the affected vessel (range of degrees of stenosis, 17 to 87 percent). (
  • In humans, basal myocardial blood flow remains constant regardless of the severity of coronary-artery stenosis. (
  • CTCA images were interpreted for presence and severity of stenosis. (
  • Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis. (
  • The severity of the aortic valve stenosis is being assessed by DSCT and TTE. (
  • However, controversy exists over whether microcirculatory resistance, a measure of coronary microcirculatory status, is dependent on epicardial stenosis severity. (
  • Previous studies demonstrating that microcirculatory resistance is dependent on epicardial stenosis severity have not accounted for collateral flow in their measurement of microcirculatory resistance. (
  • Coronary microcirculatory resistance is independent of functional epicardial stenosis severity when collateral flow is taken into account. (
  • Third, a compliant arc of normal arterial wall borders part of the lumen in the majority of coronary lesions. (
  • Subsequently, the resulting strong classification function is used in order to detect different types of coronary lesions in previously unseen data. (
  • AbstractPurpose of ReviewThe purpose of this article is to review the basic principles of near-infrared spectroscopy (NIRS) and its contemporary role in intracoronary imaging.Recent FindingsNIRS has been demonstrated to effectively detect culprit lesions in acute coronary syndromes (ACS) and to potentially identify vulnerable plaque. (
  • In recent years, a large body of evidence has revealed the limitations of angiographic evaluation in determining the physiological significance of coronary stenosis, particularly when these are intermediate lesions. (
  • Aortic Stenosis . (
  • The authors conclude that aortocoronary bypass surgery for severe stenosis of the left main coronary artery can be safely accomplished, without prophylactic use of intra-aortic balloon counterpulsation in the majority of cases, with an acceptable operative mortality and morbidity. (
  • Conclusion Our find-ings indicated high aortic plasma levels and significant correlation of Ang II with PAI-1 in patients with coronary stenosis ,suggesting that disorders in the renin-angiotensin system and fibrinolytic system may interact and concurrently contribute to the development of coronary artery stenosis. (
  • We describe a technique of combined transcatheter aortic valve replacement (TAVR), off-pump single coronary artery bypass, and percutaneous coronary intervention (PCI) in a high-risk patient presenting with unstable angina and severe heart failure. (
  • This patient had documented moderate to severe aortic stenosis, left ventricular dysfunction, and a heavily calcified ascending aorta. (
  • Physical examination followed by echocardiography demonstrates aortic stenosis. (
  • In aortic stenosis, the left ventricular pressure (choice B) becomes excessively high because the resistance of the aortic valve orifice is higher than normal. (
  • In general, Coronary ostial stenosis rarely occurs in patient after the replacement of the aortic valve. (
  • It takes place after the aortic valve replacement procedure either in the left or right coronary blood vessel. (
  • See related handout on aortic stenosis , written by the authors of this article. (
  • Although the survival rate in asymptomatic patients with aortic stenosis is comparable to that in age-and sex-matched control patients, the average overall survival rate in symptomatic persons without aortic valve replacement is two to three years. (
  • During the asymptomatic latent period, left ventricular hypertrophy and atrial augmentation of preload compensate for the increase in afterload caused by aortic stenosis. (
  • Aortic valve replacement should be recommended in most patients with any of these symptoms accompanied by evidence of significant aortic stenosis on echocardiography. (
  • Watchful waiting is recommended for most asymptomatic patients, including those with hemodynamically significant aortic stenosis. (
  • Cardiology referral is recommended for all patients with symptomatic aortic stenosis, those with severe aortic stenosis without apparent symptoms, and those with left ventricular dysfunction. (
  • Aortic valve stenosis affects 3 percent of persons older than 65 years and leads to greater morbidity and mortality than other cardiac valve diseases. (
  • 1 The pathology of aortic stenosis includes processes similar to those in atherosclerosis, including lipid accumulation, inflammation, and calcification. (
  • 2 The development of significant aortic stenosis tends to occur earlier in those with congenital bicuspid aortic valves. (
  • Echocardiography is recommended in patients with classic symptoms of aortic stenosis accompanied by a systolic murmur and in asymptomatic patients with a grade 3/6 or louder systolic murmur. (
  • Aortic valve replacement is the only effective treatment for patients with severe symptomatic aortic stenosis. (
  • Intensive lipid-lowering therapy has not been shown to stop the progression of calcific aortic stenosis and is not recommended in the absence of other indications for statin therapy. (
  • Diagnosis of functionally significant coronary stenosis with exercise CT myocardial perfusion imaging. (
  • To assess the feasibility of exercise perfusion computed tomography (CT) in patients suspected of having hemodynamically significant coronary stenosis. (
  • Exercise CT myocardial perfusion imaging is feasible and accurate for assessment of the functional significance of coronary stenosis. (
  • The Chocolate PTCA is indicated for dilation of the coronary artery or bypass graft stenosis for improving myocardial perfusion. (
  • Quantitative myocardial first-pass perfusion can distinguish coronary artery stenoses with a high degree of specificity and negative predictive value. (
  • HealthDay News) - For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial perfusion imaging is feasible and accurate, according to a study published in the March issue of Radiology . (
  • Michel Habis, MD, from the Centre Medico Chirurgical Parly 2 in Le Chesnay, France, and colleagues examined the feasibility of exercise perfusion CT in 32 consecutive patients suspected of having hemodynamically significant coronary stenosis. (
  • Detection of Hemodynamically Significant Coronary Artery Stenosis: Incremental Diagnostic Value of Dynamic CT-based Myocardial Perfusion Imaging. (
  • Fusion of CTCA and stress perfusion can help determine the hemodynamic impact of stenosis in one test, in good agreement with CT-FFR. (
  • Area under the receiver-operating-characteristic curve (AUC) was used to evaluate the diagnostic accuracy of the most severe coronary artery stenosis in a subset of 63 patients assessed by QCTA and QCA for detecting myocardial perfusion abnormalities on exercise or pharmacologic stress SPECT. (
  • AUC did not improve after excluding studies with fixed myocardial perfusion abnormalities and total coronary arterial occlusions. (
  • Coronary artery stenosis assessment by QCTA or QCA only modestly predicts the presence and the absence of myocardial perfusion abnormalities by SPECT. (
  • This study was performed to determine if a coronary artery stenosis would result in more-severe perfusion abnormalities in hypertrophied compared with normal canine hearts during exercise. (
  • Myocardial blood flow was measured by the microsphere method during treadmill exercise in the presence of a coronary artery stenosis that decreased distal coronary perfusion pressure to 55 or 42 mm Hg. (
  • A complication of INTERNAL MAMMARY-CORONARY ARTERY ANASTOMOSIS whereby an occlusion or stenosis of the proximal SUBCLAVIAN ARTERY causes a reversal of the blood flow away from the CORONARY CIRCULATION, through the grafted INTERNAL MAMMARY ARTERY (internal thoracic artery), and back to the distal subclavian distribution. (
  • There were 53 cases with 50% or greater asymptomatic carotid stenosis or occlusion, including 28 with 80% or greater stenosis or occlusion. (
  • Having visited a number of educational websites, you recognise that this finding may signify left main coronary artery (LMCA) occlusion. (
  • Abbildung 2a-b: CAG demonstrating: (A) a total occlusion of the LAD stent (arrow) 3 years post implantation and (B) the final angiographic result after coronary DES-stenting. (
  • The coronary ostial stenosis is due to failure and occlusion of atherosclerotic plaque. (
  • However, myocardial ischemia may occur with less than 50% occlusion to the coronary artery. (
  • Background: Isolated stenosis of the left anterior descending coronary artery can be treated with medication, percutaneous transluminal coronary angioplasty, or coronary artery bypass grafting. (
  • Methods: To compare minimally invasive bypass with angioplasty, we evaluated in-hospital results and 1-year follow-up in 181 consecutive patients with isolated type C stenosis of the left anterior descending coronary artery between January 1995 and July 1996. (
  • This study shows that the need for repeated revascularization, and therefore the use of health care resources, is significantly less with minimally invasive bypass than with angioplasty in patients with isolated type C stenosis of the left anterior descending coronary artery. (
  • This set of medical illustrations depicts coronary artery stenosis with angioplasty. (
  • Once ACAD has been established, treatments such as coronary angioplasty, coronary stenting, and coronary bypass are performed. (
  • The most common of the surgeries for the treatment of Coronary Stenosis is angioplasty. (
  • The patients who were suffered from ostial stenosis were kept away by angioplasty. (
  • Coronary Ostial Stenosis also treated by following the angioplasty that would be better performed when treated with CABG procedures effectively. (
  • Evaluation of transluminal angioplasty of chronic coronary artery stenosis. (
  • However, the acceptance of FFR by cardiologists contrasts with important voids in knowledge on the basic principles of coronary physiology and of other available techniques that, as an alternative to FFR, allow a more comprehensive assessment of coronary circulation. (
  • Assessment of computed tomography coronary angiograms for diagnostic purposes is a mostly manual, timeconsuming task demanding a high degree of clinical experience. (
  • Patients with ACS may be evaluated by functional assessment in the non-culprit stenosis during the index PCI revascularization or in a staged procedure. (
  • iFR® is a pressure-derived, hyperemia-free index for the assessment of coronary stenosis relevance. (
  • Coronary stenosis, Imaging, Structure and Physiology has become an important reference textbook for all those interested in the assessment and treatment of diseases affecting coronary circulation. (
  • The anatomical assessment of the hemodynamic significance of coronary stenoses determined either by CTCA, CCA, QCT, or QCA does not correlate well with the functional assessment of FFR. (
  • In this review, we will discuss the FFR, the iFR, and their use in the functional assessment of coronary stenosis in the cardiac catheterization laboratory. (
  • This review will cover theoretical aspects for non-interventional cardiologists, as well as practice points and common pitfalls related to coronary physiological assessment for interventional cardiologists. (
  • This study includes the assessment of patients with symptomatic valve stenosis. (
  • Invasive coronary microcirculation assessment--current status of index of microcirculatory resistance. (
  • The combined contribution of PTX3 and calcium score may help us identify individuals with significant coronary artery stenosis without needing to perform cardiac catheterization in a select group of patients. (
  • However, FFR can only be measured via invasive coronary catheterization, which may result in higher medical cost and complications [ 4 ]. (
  • Serological investigation for syphilis was positive, and initially the possibility that coronary ostial stenosis was the cause of his symptoms was strongly considered. (
  • Patients suffer from coronary ostial stenosis due to the radiation affected capillary. (
  • However, DS cannot characterize hemodynamic functional significance of coronary stenosis on myocardial blood supply. (
  • In terms of hemodynamic indexes to quantify the functional significance of coronary stenosis, fractional flow reserve (FFR) is the gold standard to guide coronary interventions [ 3 - 6 ] because of its significantly fewer follow-up coronary events over DS. (
  • surgery ( coronary artery bypass graft, or CABG). (
  • ANGELES - Coronary artery bypass grafting (CABG). (
  • coronary artery bypass graft , or CABG). (
  • Insufficient capacity for coronary artery bypass grafting surgery (CABG) results in waiting time before surgery, in patients being assigned to different waiting times and in risk of death among the patients who are waiting. (
  • 1 The impact of stenosis of the left main coronary artery on mortality and morbidity among patients waiting to undergo CABG is not clear, but in 2 large retrospective cohort studies the condition was not associated with increased waiting-time mortality. (
  • In a study published in this issue 4 (see page 371), Légaré and associates investigate pre- and postoperative mortality and morbidity in a group of patients with stenosis of the left main coronary artery who were scheduled to undergo CABG. (
  • In 2002, more than 500,000 coronary artery bypass graft (CABG) surgeries and nearly 1.2 million percutaneous coronary interventions (PCI) including coronary stent implantations were performed in the US. (
  • We report the early and late results of coronary artery bypass graft (CABG) for protected and unprotected left main coronary artery (LMS) stenosis in an era of growing interest in LMS stenting. (
  • We aimed to compare the long-term performance of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in treatment of left main CAD. (
  • The patient was subjected to coronary artery bypass graft (CABG) surgery with saphenous grafts to the proximal LAD as well as its first diagonal branch. (
  • The treatment carried out is Coronary Artery Bypass Graft ( CABG ) . (
  • Background and Purpose- Intracranial arterial stenosis (ICAS) is considered an important cause of stroke in Asians. (
  • In 18 of the remaining 57 cases (31.5%), significantly obstructive atherosclerosis in one or more segments of the coronary arterial system was found. (
  • 3DMP's computer-based, mathematically derived analysis of resting two-lead ECG data provides detection of hemodynamically relevant CAD in patients with a history of coronary revascularization with high sensitivity and specificity that appears to be at least as good as those reported for other resting and/or stress ECG methods currently used in clinical practice. (
  • Methods We investigated 79 patients with stable angina pectoris who underwent both 64-slice or dual-source CTCA and FFR measurement of discrete coronary stenoses. (
  • Methods In 325 patients scheduled for PCI of an intermediate stenosis, FFR was measured just before the planned intervention. (
  • METHODS: Transthoracic Doppler echocardiography was used to register coronary flow in 10 age-matched healthy controls and 7 neonates before and 1 day after BV. (
  • 7) The entropy filter and the Hough transformation methods are applied for each segment to detect stenosis on vessels. (
  • Coronary flow reserve can be measured through a variety of methods, including digital subtraction cineangiography with coronary catheterization, doppler echocardiography, and positron emission tomography (PET). (
  • The prevalence of RAS in patients with suspected cardiovascular disorders who have undergone cardiac catheterization was reported as 11.3 to 39%, whereas the RAS with stenosis of more than 50% has been reported as 6.3 to 28% [ 3 ]. (
  • The presented experimental in vitro approach was designed to assess the expansion behavior of stent systems in a resistant focal stenosis model with respect to a potential dog-boning effect. (
  • None of the stent systems failed under the extremely high stress at the edges of the focal stenosis. (
  • B. Braun won a CE mark for a new stent designed to treat coronary artery stenosis. (
  • How does coronary stent implantation impact on the status of the microcirculation during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction? (
  • before or after heart bypass surgery ( coronary . (
  • After excluding 27 patients with a history of coronary bypass surgery, we analysed the remaining 229 patients in our current study. (
  • The patient underwent triple coronary artery bypass surgery, and sorafenib treatment was discontinued. (
  • In this type of coronary stenosis , a bypass surgery is required. (
  • Fractional flow reserve (FFR) is the gold standard to guide coronary interventions. (
  • What are the implications of coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR) in patients with intermediate stenosis and high fractional flow reserve (FFR)? (
  • In 325 patients scheduled for percutaneous coronary intervention (PCI) of an intermediate stenosis, fractional flow reserve (FFR) was measured. (
  • Coronary pressure-derived fractional flow reserve (FFR) is an invasive index used to identify a stenosis responsible for reversible ischemia. (
  • 0.001), and the difference between the IMR(app) and IMR(true) became greater with decreasing fractional flow reserve and increasing coronary wedge pressure. (
  • Coronary artery calcification (CAC) is a surrogate marker for subclinical atherosclerosis. (
  • 50% intracranial stenosis based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis trial. (
  • UMI is common in patients with stable angina and the results indicate that the majority of the UMIs are of ischemic origin due to severe coronary atherosclerosis. (
  • A pathological diagnosis of early coronary atherosclerosis was made. (
  • This lesion has been previously termed 'coronary intimal fibrous stenosis' as the authors concerned did not believe that it was due to coronary atherosclerosis. (
  • The 'classic' features of coronary atherosclerosis may not have been evident on account of the patient's dietary habits, which may prove to be the important pathological differentiating feature in our White and Coloured population groups. (
  • The failure of coronary artery bypass procedures has been attributed to both intimal hyperplasia (IH) and atherosclerosis. (
  • Although approximately 15-20% of all percutaneous coronary interventions (PCI) are performed in this anatomical location, choosing the most adequate treatment is still the subject of considerable debate. (
  • Multidetector computed tomography was used to assess coronary artery calcium score (CACS). (
  • Therefore, a remarkable technical progress has been achieved by both cardiac magnetic resonance and cardiac computed tomography in this regard for the noninvasive detection of coronary stenoses. (
  • Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study. (
  • Cross-sectional images at the level of the most severe narrowing can be compared to a reference minimal lumen diameter averaging the segments proximal and distal to the stenosis. (
  • FFR is calculated as a ratio of the pressure distal versus pressure proximal to a stenosis following vasodilation. (
  • The coronary stenosis placed around the proximal left anterior descending coronary artery (LAD) allowed normal blood flow at rest but only minimum hyperemia in response to the coronary dilator, adenosine. (
  • article{aaaf1de4-de34-469a-ad34-52c691970e90, abstract = {BACKGROUND: Treating pulmonary valve stenosis with balloon valvuloplasty (BV) is a good model to study the effect of right ventricular (RV) pressures on coronary flow. (
  • Narrowing or constriction of a coronary artery. (
  • Compensatory changes of the distal coronary vascular bed during progressive coronary constriction. (
  • In addition, blood samples were drawn for coronary sinus PTX3, and also PTX3, uric acid, high-sensitivity C-reactive protein (hs-CRP), cholesterol, glucose and High-Density Lipo-protein (HDL) in peripheral circulation. (
  • However, nicotine may have adverse effects on coronary circulation. (
  • Blood flow through the coronary circulation is regulated almost entirely by the metabolic requirements of the cardiac muscle. (
  • We believe that the mainstem obstruction was due to coronary artery fibromuscular hyperplasia, a condition rarely affecting the coronary artery circulation. (
  • Revascularization is commonly recommended when the coronary stenosis leads to FFR ≤ 0.80. (
  • The purpose of this study is to determine whether preventive coronary intervention on functionally insignificant coronary stenosis with vulnerable plaque characteristics plus optimal medical therapy reduces the incidence of the composite of cardiovascular death, target vessel myocardial infarction, or ischemia driven target lesion revascularization compared with optimal medical therapy alone. (
  • Grube E, Bootsveld A, Buellesfeld L, Yuecel S, Shen JT, Imhoff M. Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis after coronary revascularization. (
  • Coronary restenosis after PCI and bypass graft and de-novo coronary stenosis are not infrequent after revascularization and remain significant clinical issues [ 2 ]. (
  • It is generally accepted that revascularization of a coronary stenosis responsible for reversible ischemia is justified as it relieves anginal complaints, and in some situations improves patient outcome ( 1-6 ). (
  • The majority of IPA stenoses occurred in the mid to distal IPA and appears amenable to percutaneous revascularization. (
  • The degree of stenosis could be assessed on this view visually, or from manually or software-calculated diameter or cross-sectional area. (
  • As a result, seemingly small changes in diameter are amplified to large changes in stenosis resistance. (
  • This extremely important morphologic feature of stenoses permits transient variation in stenosis lumen diameter in response to drugs or to variation in endogenous vasomotor activity or intraluminal pressure. (
  • Precise Measurement of Coronary Stenosis Diameter with CCTA Using CT Number Calibration. (
  • In this paper, we introduce a new technique called CT-number-Calibrated Diameter to improve the accuracy of the vessel and stenosis diameter measurements with CCTA. (
  • In contrast, flow during hyperemia correlated inversely and significantly with the degree of stenosis and correlated directly with the minimal luminal diameter. (
  • The detected stenosis is marked on the center- line image and the plotted diameter on the correspondence to its position. (
  • Publications] 柳原 圭雄: 'A Study of Magnification and Smoothing effect on Accurate Computerized Measurement of vessel diameter of coronary cineangiograms using a tele-cine converter' MEDICAL IMAGING TECHNOLOGY. (
  • Publications] Y.Yanagihara: 'A Study of Magnification and Smoothing Effect on Accurate Computerized measurement of Vessel Diameter of Coronary Cineangiograms using a tele-cine converter. (
  • Ischemic episodes occur when pressure distal to the stenosis falls below that needed to perfuse the subendocardium. (
  • The microvascular functional changes distal to the stenosis have not been studied in detail. (
  • Distal to a chronic coronary artery stenosis, structural remodeling of the microvasculature occurs. (
  • These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis. (
  • Over a 2-year period 33 patients with symptomatic stenosis (greater than 75%) of the left main coronary artery underwent aortocoronary bypass. (
  • [ 78 ] Grading is less accurate in calcified plaques and in distal coronary vessels. (
  • stenosis in two or more major coronary vessels (83 percent. (
  • Publications] Y.Yanagihara: 'Separation Method of Solid Crossing of Vessels on a Coronary Cineangiogram. (
  • The adenosine then dilates the coronary blood vessels, increasing oxygen delivery to an adequate level. (
  • Background Percutaneous coronary intervention (PCI) of an intermediate stenosis without evidence of ischemia is often performed, but its benefit is unproven. (
  • The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. (
  • Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction. (
  • The greatest potential for this change is normally in the branches (arterioles) of the coronary artery that penetrate the myocardium, rather than those on the surface of the heart. (
  • Carotid stenosis and perioperative stroke risk in symptomatic and asymptomatic patients undergoing vascular or coronary surgery. (
  • We aimed to define the relation of carotid stenosis to perioperative stroke in all patients, symptomatic and asymptomatic, and so determine a policy for the management of asymptomatic carotid stenosis in patients requiring major surgery. (
  • Two of these occurred ipsilateral to symptomatic carotid occlusions, and 1 occurred ipsilateral to an 80% symptomatic stenosis. (
  • One symptomatic patient with bilateral 30% stenosis had a perioperative infarct in the asymptomatic hemisphere. (
  • We conclude that the risk of perioperative stroke related to symptomatic carotid stenosis may be high, but for asymptomatic carotid stenosis the risk is low and does not justify preoperative prophylactic carotid endarterectomy. (
  • MIP images parallel to the long axis of the vessel can be used to assess the degree of stenosis. (
  • The coronary vasodilator reserve (defined as the ratio of flow during hyperemia to flow at base line) began to decline when the degree of stenosis was about 40 percent and approached unity when stenosis was 80 percent or greater. (
  • However, during hyperemia, flow progressively decreases when the degree of stenosis is about 40 percent or more and does not differ significantly from basal flow when stenosis is 80 percent or greater. (
  • Critical coronary stenosis would be defined as the degree of stenosis at which significant changes in ischemia-related oxidative stress (antioxidant reserve and/or MDA) will first be apparent. (
  • It has not been documented, however, whether in the presence of coronary stenosis atrial fibrillation exceeds the effects of rhythmic atrial tachycardia. (
  • 6. Thus atrial fibrillation may reduce coronary blood flow and induce myocardial ischaemia in the presence of coronary stenosis in excess of atrial tachycardia. (
  • Maximum intensity projection (MIP): MIP image of a left anterior descending (LAD) artery stenosis secondary to calcified plaque. (
  • End-on" multiplanar reformat (MPR): "End-on" MPR view (perpendicular to the median centerline of the vessel) of a left anterior descending (LAD) artery stenosis secondary to calcified plaque. (
  • Left main coronary artery stenosis. (
  • A coronary stenosis of ≥70% was considered to be severe for the left anterior descending artery (LAD), left circumflex artery (LCx) and right coronary artery (RCA). (
  • Aortocoronary bypass for critical stenosis of the left main coronary artery. (
  • Should patients with stenosis of the left main coronary artery waiting for bypass grafting be given priority? (
  • Independent risk factors for the composite outcome included age greater than 70 years, preoperative renal failure, left ventricular ejection fraction of less than 40%, myocardial infarction in the 7 days before surgery and stenosis of left main artery greater than 70%, but did not include queue assignment. (
  • The authors conclude that waiting for surgery with stenosis of the left main artery is safe and not associated with increased pre- or postoperative mortality or morbidity. (
  • The first is whether patients with stenosis of the left main coronary artery have an increased risk of death in any category of waiting list. (
  • This rate is markedly higher than that previously reported from waiting list registers (4-8 deaths per 100 patient years) 3 , 5 , 6 , 7 and does not support the statement that waiting-time mortality is low for patients with stenosis of the left main coronary artery. (
  • The second issue is whether postoperative morbidity and mortality are influenced by stenosis of the left main coronary artery. (
  • BestBets: Is ST elevation in aVR a sure sign of left main coronary artery stenosis? (
  • OR left main coronary (
  • OR left main stem coronary (
  • The first image shows the heart, indicating the location of a blockage within the left anterior descending (LAD) coronary artery. (
  • Abbildung 1a-b: CAG demonstrating: (A) a 90 % bifurcational LM stenosis (left arrow) and an 80 % LAD stenosis (right arrow) and (B) the angiographic result after DES-stenting of the LAD and bifurcation stenting of the LM (arrow). (
  • BACKGROUND: A stenosis of left main coronary artery has critical prognostic importance. (
  • We evaluated recent four-year trends in incidence, clinical, angiographic findings and treatment modalities in patients with left main coronary artery stenosis(LMS). (
  • Vasomotor tone was studied in coronary microvessels from healthy control swine and from swine 3 to 4 months after implantation of an occluder that causes a progressive coronary narrowing, resulting in regional left ventricular dysfunction and blunted myocardial vasodilator reserve. (
  • Ihekwaba FN, Davidson KG, Ogilvie B, Caves PK (1976) Anomalous origin of the left artery with coronary artery coronary artery from the pulmonary steal in adults Report of two cases and review of the literature. (
  • Alexi-Meskishvili V, Berger F, Weng Y, Lange PE, Hetzer R (1995) Anomalous origin of the left coronary artery from the pulmonary artery in adults. (
  • Kristensen T, Kofoed KF, Helqvist S, Helvind M, Søndergaard L (2008) Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) presenting with ventricular fibrillation in an adult: a case report. (
  • Parale GP, Pawar SS (2006) Adult type anomalous left coronary artery from pulmonary artery. (
  • At operation three coronary artery bypass grafts were inserted, one to the left anterior descending artery and two to the left circumflex coronary artery, with a most successful result. (
  • The pressure-flow characteristics of 100 left circumflex stenoses in 10 chronically instrumented unsedated dogs were studied under resting conditions and during pharmacological coronary vasodilation. (
  • We present a case of successful stenting of the left main coronary artery (LMCA) in a patient with ACAD. (
  • The left circumflex coronary artery also showed some insignificant internal luminal irregularities. (
  • 70-90% stenosis of my Left Anterior Descending artery and 50-60% of the Right Coronary Artery. (
  • Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle. (
  • At a coronary pressure of 55 mm Hg, mean myocardial blood flow was decreased by 23 +/- 5% in normal control dogs but was decreased by 53 +/- 10% in dogs with left ventricular hypertrophy (LVH) (p less than 0.05, comparing normal vs. LVH dogs). (
  • The reference IPA diameters at the point of maximal stenosis were 2.7 ± 0.4 mm (right IPA) and 2.7 ± 0.5 mm (left IPA). (
  • Distal unprotected left main coronary artery (ULMCA) stenosis represents a technical challenge for interventional cardiologists. (
  • For each dog, following thoracotomy, a hydraulic occluder was placed around the left circumflex coronary artery (LCX) to induce reversible LCX stenoses. (
  • During the 4th (current) presentation, we detected and percutaneously treated severe stenoses in the patient's left anterior descending coronary artery and 2nd obtuse marginal branch. (
  • Coronary stenosis located at vessel bifurcations are frequent in everyday clinical practice. (
  • CCTA enables accurate evaluation of coronary artery stenosis. (
  • In this paper, we propose a fast and fully automatic system that is capable of detecting, grading and classifying coronary stenoses in CCTA caused by all types of plaques. (
  • After adjusting for several variables, including diabetes, smoking status, hypertension and hypercholesterolaemia, predictors of severe stenosis were male gender, odds ratio (OR) 2.7 (95% confidence interval (CI) 1.5-4.9), older age, OR 1.9 (95% CI 1.02-3.54) previous PCI, OR 2.0 (95% CI 1.0-4.3) and typical angina, OR 2.5 (95% CI 1.4-4.6). (