Narrowing or constriction of a coronary artery.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The circulation of blood through the CORONARY VESSELS of the HEART.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Spasm of the large- or medium-sized coronary arteries.
Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.
Narrowing of the spinal canal.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Narrowing of the pyloric canal with varied etiology. A common form is due to muscle hypertrophy (PYLORIC STENOSIS, HYPERTROPHIC) seen in infants.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Pathologic deposition of calcium salts in tissues.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Pressure, burning, or numbness in the chest.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Elements of limited time intervals, contributing to particular results or situations.
Drugs used to cause dilation of the blood vessels.
Contractile activity of the MYOCARDIUM.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
The hollow, muscular organ that maintains the circulation of the blood.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Substances used to allow enhanced visualization of tissues.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Radiography of blood vessels after injection of a contrast medium.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The innermost layer of the heart, comprised of endothelial cells.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Motion pictures of the passage of contrast medium through blood vessels.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The return of a sign, symptom, or disease after a remission.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Lesions formed within the walls of ARTERIES.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The flow of BLOOD through or around an organ or region of the body.
A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Pathological processes involving any part of the AORTA.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Obstruction of flow in biological or prosthetic vascular grafts.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Freedom from activity.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
The act of constricting.
Computer systems or networks designed to provide radiographic interpretive information.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Narrowing of the pyloric canal due to HYPERTROPHY of the surrounding circular muscle. It is usually seen in infants or young children.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Disease having a short and relatively severe course.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
A stricture of the ESOPHAGUS. Most are acquired but can be congenital.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The vein which drains the foot and leg.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Radiography of the vascular system of the brain after injection of a contrast medium.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY.
The vessels carrying blood away from the heart.
Formation and development of a thrombus or blood clot in the blood vessel.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A characteristic symptom complex.
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)
The plan and delineation of prostheses in general or a specific prosthesis.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.

Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions. (1/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. METHODS AND RESULTS: FFR and CFR were assessed in 126 consecutive patients with 150 intermediate coronary lesions (between 40% and 70% diameter stenosis by visual assessment). Agreement between outcomes of FFR and CFR, categorized at cut-off values of 0.75 and 2.0, respectively, was observed in 109 coronary lesions (73%), whereas discordant outcomes were present in 41 lesions (27%). In 26 of these 41 lesions, FFR was <0.75 and CFR>or=2.0 (group A); in the remaining 15 lesions, FFR was >or=0.75 and CFR<2.0 (group B). Minimum microvascular resistance, defined as the ratio of mean distal pressure to average peak blood flow velocity during maximum hyperemia, showed a large variability (overall range, 0.65 to 4.64 mm Hg x cm(-1) x s(-1)) and was significantly higher in group B than in group A (2.42+/-0.77 versus 1.91+/-0.70 mm Hg x cm(-1) x s(-1); P:=0.034). CONCLUSIONS: Our findings demonstrate the prominent role of microvascular resistance in modulating the relationship between FFR and CFR and emphasize the importance of combined pressure and flow velocity measurements to evaluate coronary lesion severity and microvascular involvement.  (+info)

Serial intravascular ultrasound analysis of the impact of lesion length on the efficacy of intracoronary gamma-irradiation for preventing recurrent in-stent restenosis. (2/1816)

BACKGROUND: The relation between lesion length and effectiveness of brachytherapy is not well studied. METHODS AND RESULTS: We compared serial (postintervention and follow-up) intravascular ultrasound findings in 66 patients with native coronary artery in-stent restenosis (ISR) who were treated with (192)Ir (15 Gy delivered 2 mm away from the radiation source). Patients were enrolled in the Washington Radiation for In-Stent Restenosis Trial (WRIST; ISR length, 10 to 47 mm; n=36) or Long WRIST (ISR length, 36 to 80 mm; n=30). External elastic membrane, stent, lumen, and intimal hyperplasia (IH; stent minus lumen) areas and source-to-target (intravascular ultrasound catheter to external elastic membrane) distances were measured. Postintervention stent areas were larger in WRIST and smaller in Long WRIST patients (P:<0.0001). At follow-up, maximum IH area significantly increased in both WRIST and Long WRIST patients (P:<0.0001 for both), but this increase was greater in Long WRIST patients (P:=0.0006). Similarly, minimum lumen cross-sectional area significantly decreased in both WRIST and Long WRIST patients (P:<0.05 and P:<0.0001, respectively), but this decrease was more pronounced in Long WRIST patients (P:=0.0567). The maximum source-to-target distance was longer in Long WRIST than in WRIST, and it correlated directly with ISR length (r=0.547, P:<0.0001). Overall, the change in minimum lumen area and the change in maximum IH area correlated with the maximum source-to-target distance (r=0.352, P:=0.0038 and r=0.523, P:<0.0001 for WRIST and Long WRIST, respectively). The variability (maximum/minimum) in IH area at follow-up also correlated with the maximum source-to-target distance (r=0.378, P:<0.0001). CONCLUSIONS: Brachytherapy may be less effective in longer ISR lesions because of the greater variability and longer source-to-target distances in diffuse ISR.  (+info)

Impact of peri-stent remodeling on restenosis: a volumetric intravascular ultrasound study. (3/1816)

BACKGROUND: Vessel remodeling is an important mechanism of late lumen loss after nonstent coronary interventions. However, its impact on in-stent restenosis has not been systematically investigated. METHODS AND RESULTS: Serial volumetric intravascular ultrasound analyses (poststent and follow-up) were performed in 55 lesions treated with a balloon-expandable stent (ACS MultiLink) using standard stent deployment techniques. The vessel volume (VV), lumen volume (LV), and volume bordered by the stent (SV) were measured using Simpson's method. The volume of plaque and neointima outside the stent (peri-stent volume, PSV) and volume of neointima within the stent (intrastent volume) were also measured. The change of each parameter during the follow-up period (follow-up minus poststent) was calculated and then divided by SV to normalize these values (designated as percent change [%]). As expected, %PSV directly correlated with %VV (P<0.0001, r=0.935), with no significant SV. A highly significant inverse correlation was seen between %PSV and the percent change of intrastent volume (P<0.0001, r=0.517). Consequently, %LV significantly correlated with peri-stent remodeling, as measured by %VV (P<0.0001, r=0.602). CONCLUSION: Positive remodeling of the vessel exterior to a coronary stent occurs to a variable degree after stent implantation. There is a distinct trade-off between positive remodeling and in-stent hyperplasia: in segments in which the degree of peri-stent remodeling is less, intrastent neointimal proliferation is greater and accompanied by more significant late lumen loss.  (+info)

Magnesium deficiency in patients with recent myocardial infarction and provoked coronary artery spasm. (4/1816)

This study sought to clarify the relationship between magnesium (Mg) deficiency and coronary artery spasm provoked by pharmacologic agents in patients with a recent acute myocardial infarction (AMI). Twenty-three consecutive patients suffering from AMI were investigated with a Mg retention test (Mg: 0.1 mmol/kg for 4 h) in both the acute phase (within I week (3+/-2 days) of onset) and the subacute phase (3-4 weeks (24+/-6 days) of the onset). Early coronary arteriography was performed in all patients. Coronary stenosis in the infarct-related artery was less than 90% in all patients in the subacute phase. The spasm provocation test was performed in the subacute phase and coronary spasm was defined as transient subtotal or total occlusion in association with angina or electrocardiographic ST-segment deviation. Coronary artery spasm was provoked in only 13 of the 23 patients. Compared with the control subjects (12 patients without coronary artery disease or coronary spasm), the 24-h Mg retention was significantly higher in patients with AMI (acute phase: 78+/-27%, subacute phase: 66+/-32%, vs control: 48+/-12%, p<0.05). In the subacute phase, the 24-h Mg retention decreased in patients without coronary spasm (43+/-26%), but a high level of Mg retention was still observed in patients with coronary spasm (84+/-25%). There was no difference in the serum concentrations of Mg, calcium and phosphorus between the 2 groups on both phases. In conclusion, both Mg deficiency and provoked coronary artery spasm were noted in more than half of the Japanese patients with a recent AMI, suggesting a close association between Mg deficiency and AMI.  (+info)

Seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. (5/1816)

Infections are assumed to play a role in coronary artery disease (CAD) and cardiomyopathies. It is unknown whether the seroprevalence of antibodies to these microorganisms is higher in patients with than without CAD. The seroprevalence of antibodies to Bartonella henselae, Borrelia burgdorferi, Chlamydia pneumoniae, Coxiella burnetii, Helicobacter pylori, human granulocytic Ehrlichia, Leptospira, Rickettsia conorii, and Treponema pallidum was assessed prospectively in patients with exertional dyspnea or anginal chest pain who underwent coronary angiography because of suspected CAD. Patients with normal angiograms (NA) were those in whom no more than 50% stenosis of any coronary artery was found. Patients with CAD were patients who underwent percutaneous transluminal coronary angioplasty. There were 50 patients with CAD (9 female) and 62 with NA (25 female), with a mean age of 62 years. All patients had antibodies to at least one microorganism: to B. henselae, 8% of CAD patients and 5% of NA patients; to B. burgdorferi IgG, 14% CAD and 6% NA; to B. burgdorferi IgM, 6% CAD and 3% NA; to C. pneumoniae lipopolysaccharide (LPS) IgA, 76% CAD and 77% NA; to C. pneumoniae LPS IgG, 80% CAD and 90% NA; to C. burnetii, 0% CAD and 5% NA; to H. pylori, 92% CAD and 68% NA; to human granulocytic Ehrlichia, 8% CAD and 3% NA; to Leptospira IgG, 4% CAD and 2% NA; to R. conorii, 10% in both groups; and to T. pallidum, 2% CAD and 0% NA. The seroprevalence of antibodies to micro-organisms known to induce arterial and myocardial damage does not differ between patients with CAD and NA.  (+info)

Dobutamine stress echocardiography versus quantitative technetium-99m sestamibi SPECT for detecting residual stenosis and multivessel disease after myocardial infarction. (6/1816)

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN: Prospective study. SETTING: University hospital. METHODS: 75 patients underwent simultaneous DSE and mibi SPECT at (mean (SD)) 5 (2) days after a first acute myocardial infarct. Quantitative coronary angiography was performed in all patients after imaging studies. RESULTS: Significant stenosis (> 50%) of the infarct related artery was detected in 69 patients. Residual ischaemia was identified by DSE in 55 patients and by quantitative mibi SPECT in 49. The sensitivity of DSE and mibi SPECT for detecting significant infarct related artery stenosis was 78% and 70%, respectively, with a specificity of 83% for both tests. The combination of DSE and mibi SPECT did not change the specificity (83%) but increased the sensitivity to 94%. Mibi SPECT was more sensitive than DSE for detecting mild stenosis (73% v 9%; p = 0.008). The sensitivity of DSE for detecting moderate or severe stenosis was greater than mibi SPECT (97% v 74%; p = 0.007). Wall motion abnormalities with DSE and transient perfusion defects with mibi SPECT outside the infarction zone were sensitive (80% v 67%; NS) and highly specific (95% v 93%; NS) for multivessel disease. CONCLUSIONS: DSE and mibi SPECT have equivalent accuracy for detecting residual infarct related artery stenosis of >/= 50% and multivessel disease early after acute myocardial infarction. DSE is more predictive of moderate or severe infarct related artery stenosis. Combined imaging only improves the detection of mild stenosis.  (+info)

Value of fractional flow reserve in making decisions about bypass surgery for equivocal left main coronary artery disease. (7/1816)

OBJECTIVE: To investigate the value of coronary pressure derived fractional flow reserve (FFR) measurements in supporting decisions about medical or surgical treatment in patients with angiographically equivocal left main coronary artery stenosis. DESIGN: A two centre prospective single cohort follow up study. INTERVENTIONS: FFR of the left main coronary artery was determined in 54 consecutive patients with angiographically equivocal left main coronary artery disease. If FFR was >/= 0.75, medical treatment was chosen; if FFR was < 0.75, surgical treatment was chosen. MAIN OUTCOME MEASURES: Freedom from death, myocardial infarction, or any coronary revascularisation procedure. RESULTS: In 24 patients (44%), FFR was >/= 0.75 and medical treatment was chosen (medical group). In the remaining 30 patients (56%), FFR was < 0.75 and bypass surgery was performed (surgical group). Mean (SD) follow up was 29 (15) months (range 12-65 months). Survival among patients at three years of follow up was 100% in the medical group and 97% in the surgical group. Event-free survival was 76% in the medical group and 83% in the surgical group. CONCLUSIONS: FFR supports decision making in equivocal left main coronary artery disease. If FFR is below 0.75, the decision for bypass surgery is supported. If FFR is above 0.75, a conservative approach is justified.  (+info)

Coronary thermodilution to assess flow reserve: experimental validation. (8/1816)

BACKGROUND: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are indices of coronary stenosis severity that provide the clinician with complementary information on the contribution of epicardial arteries and microcirculation to total resistance to myocardial blood flow. At present, FFR and CFR can only be obtained by 2 separate guidewires. The present study tested the validity of the thermodilution principle in assessing CFR with one pressure-temperature sensor-tipped guidewire. METHODS AND RESULTS: In an in vitro model, absolute flow was compared with the inverse mean transit time (1/T(mn)) of a thermodilution curve obtained after a bolus injection of 3 mL of saline at room temperature. A very close correlation (r>0.95) was found between absolute flow and 1/T(mn) when the sensor was placed >/=6 cm from the injection site. In 6 chronically instrumented dogs (60 stenoses; FFR from 0.19 to 0.98), a significant linear relation was found between flow velocity and 1/T(mn). A significant correlation was found between CFR(Doppler), which was calculated from the ratio of hyperemic to resting flow velocities, and CFR(thermo), which was calculated from the ratio of resting to hyperemic T(mn) (r=0.76; SEE=0.24; P<0.001). CONCLUSION: The present findings demonstrate the validity of the thermodilution principle to assess CFR. Because the pressure-temperature sensor was mounted in a commercially available angioplasty guidewire, this technique permits simultaneous measurements of CFR and FFR.  (+info)

TY - JOUR. T1 - Impact of the Extent of Coronary Artery Disease on Outcomes After Revascularization for Unprotected Left Main Coronary Artery Stenosis. AU - Kim, Young Hak. AU - Park, Duk Woo. AU - Kim, Won Jang. AU - Lee, Jong Young. AU - Yun, Sung Cheol. AU - Kang, Soo Jin. AU - Lee, Seung Whan. AU - Lee, Cheol Whan. AU - Hong, Myeong Ki. AU - Park, Seong Wook. AU - Park, Seung Jung. PY - 2010/6/8. Y1 - 2010/6/8. N2 - Objectives: This study was designed to examine the impact of the extent of coronary disease on long-term outcomes after coronary stenting or coronary artery bypass graft (CABG) surgery for unprotected left main coronary artery (ULMCA) stenosis. Background: The differential outcome of ULMCA revascularization according to the coronary involvement remains uncertain. Methods: From the MAIN-COMPARE (Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty versus Surgical Revascularization) registry, 2,240 patients with ULMCA ...
In the United States, ULMCA PCI is performed primarily in patients with a high burden of comorbidities and frequently in those with high-urgency clinical presentations. In this population, in-hospital mortality was substantially higher in those with ULMCA disease who were treated percutaneously; however, this early risk is driven by those with high-urgency, rather than lower-urgency, presentations.. Among ULMCA patients selected for PCI in the United States, 30-month mortality is high (42.7%), with a predominance of cardiovascular events. These findings are especially notable when compared to the 10% mortality reported at 30 months in the MAIN-COMPARE (Korean Revascularization for Unprotected Left Main Coronary Artery Stenosis: Comparison of Percutaneous Coronary Angioplasty Versus Surgical Revascularization) study (11), and the 4% mortality reported at 1 year in the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) trial (12). The increased patient age, burden of comorbidities, and ...
The long-term safety and efficacy of drug-eluting stent (DES) implantation in the treatment of unprotected left main coronary artery (LMCA) stenosis is still a matter of debate. All consecutive patients (pts) who had sirolimus (SES, Cypher, Cordis, Johnson and Johnson Company, Warren, NJ) or paclitaxel-eluting stent (PES, Taxus, Boston Scientific, Natick, MA) electively implanted in de novo lesions on LMCA between March 2002 and July 2006 were analyzed. A total of 267 patients were treated: 107 with PES and 160 with SES. Sixty-four (23.4%) patients were diabetics, 95 (35.6%) had unstable angina, mean age was 64.5±11.6 years and LVEF 52.2±10.7 %. High mortality risk scores (Euroscore ,6) were present in 84 (31.5%) of the patients. Glycoprotein IIb/IIIa inhibitors were used in 50 (18.7%) patients, 80 (29.9%) underwent intravascular ultrasound. Distal left main lesions were present in 223 (83.5%) of the patients: 209 bifurcations and 14 trifurcations. Both branches were stented in 108 (48.4%) ...
TY - JOUR. T1 - Current management of unprotected left main coronary artery disease. T2 - Run-in survey of the RITMO (Registro Italiano sul Trattamento del tronco coMune non protettO) study. AU - Sheiban, Imad. AU - Sillano, Dario. AU - Biondi-Zoccai, Giuseppe G L. AU - De Servi, Stefano. AU - Tamburino, Corrado. AU - Marzocchi, Antonio. AU - Trevi, Gian Paolo. AU - Moretti, Claudio. PY - 2009/9. Y1 - 2009/9. N2 - The optimal approach for a significant unprotected left main coronary stenosis (ULM) is debated, in light of the recent progresses of percutaneous coronary intervention (PCI). However, coronary artery bypass grafting (CABG) is still considered the first choice treatment. Randomized trials comparing PCI and CABG are ongoing, yet patient selection will considerably limit their clinical applicability. We thus designed a prospective multicenter registry which will include patients with ULM disease independently from the subsequent medical, interventional or surgical treatment: the RITMO ...
TY - JOUR. T1 - The absence of evidence is not the evidence of absence. T2 - A case report on the challenges in diagnosing ostial left main stenosis. AU - Shaik, Ayesha. AU - Mosleh, Wassim. AU - Dahal, Khagendra. AU - Pickett, Christopher. AU - Azrin, Michael. N1 - Publisher Copyright: © 2020 Wiley Periodicals LLC. PY - 2021/4/1. Y1 - 2021/4/1. N2 - Because left main (LM) coronary artery stenosis is known to have higher mortality and morbidity compared to lesions in other territories, an early diagnosis and management are crucial to prevent worse outcomes. Due to limitations of coronary angiography (CA), the diagnosis of ostial LM stenosis solely based on CA may result in underdiagnosis of such lesions. Therefore, additional testing is often needed either by pressure wire or intravascular ultrasound (IVUS) to make appropriate diagnosis. We, hereby, present a case of left main ostial stenosis in a 56-year-old male that was missed on multiple coronary angiograms, and highlights many of the ...
Allograft vasculopathy is the leading cause of death and morbidity after the first year of transplantation. Its prevalence is high: 11%, 22%, and 45% at one, two, and four years after transplantation, respectively.13,14 The accelerated coronary artery disease involves both the epicardial and the intramyocardial arteries. Its diagnosis is difficult because of the absence of angina in the denervated heart and the low sensitivity of non-invasive stress testing.15 The first manifestation of allograft vasculopathy is often congestive heart failure, ventricular arrhythmias, or sudden death.16 The ineffective medical treatment and the limited suitability of CABG and retransplantation have motivated interest in PCI for the subset of heart transplant recipients presenting with allograft vasculopathy in proximal segments. Schnetzler and colleagues17 reported 94.3% primary success (, 50% residual stenosis) in 53 lesions. Two of these patients had symptomatic left main stenosis, which were dilated with ...
Definition of Left main coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Left main coronary artery? Meaning of Left main coronary artery as a legal term. What does Left main coronary artery mean in law?
All the papers appraised note an association between this pattern and severe stenosis of the LMCA or 3-vessel disease. However, the evidence identified from nine cohort studies consistently shows that lone ST elevation in lead aVR has little diagnostic value for identifying patients with stenosis of the LMCA. Both sensitivity and specificity are suboptimal to guide clinical decision making. The evidence suggests that diagnostic performance may improve when there is accompanying diffuse ST depression. Kosuge et al 8 found that such changes have a specificity of 93% for LMCA stenosis or 3-vessel disease, although the positive predictive value in that sample was only 58%, which limits the value of the finding for ruling in LMCA stenosis. As such, taken alone this finding could not be used to guide the need for primary percutaneous coronary intervention, for example. However, as patients with LMCA stenosis are at particularly high risk, ST elevation in aVR may help to identify patients for early ...
Background and Purpose: Acute myocardial infarction(AMI) occurs in 1-2% of patients treated with carotid artery stenting(CAS), and is considered as one of the most serious perioperative complication. We assessed coronary artery stenosis in patients treated with CAS using coronary CTA or coronary angiography.. Methods: Consecutive sixty-two patients (47 men, mean age 73.4 years) treated with CAS were examined by coronary CTA or angiography within 3 months before CAS between January 2010 and August 2012. In patients suspected coronary artery stenosis by coronary CTA, coronary angiography was performed. Significantly coronary artery stenosis was defined as that greater than 75%.. Results: CAS was performed in 62 patients, and coronary artery was evaluated in 57 patients. Patients with allergic reaction for contrast agents, renal failure, and poor general condition were excluded from this study. Thirty-eight patients had significant coronary artery stenosis. Twenty-nine of them had any history of ...
Catheter intervention treatment is now widely accepted as a nonsurgical revascularization option for adult patients with coronary artery disease. However, the experiences in KD have been limited.7,10,11 In contrast to the success of PTCA for treatment of atheromatous coronary artery disease in the adult, it was reported10,11 that PTCA is not as effective in the dilatation of the severely calcified stenotic lesions in patients with KD via balloon angioplasty. In this study, we introduced the new device of PTCRA, which was effective in ablating stenotic vessel lesions with hard calcification in the children with coronary artery stenosis after KD. Although PTCA was effective in only one of our four patients, the other three required PTCRA to ablate the hardened stenotic coronary lesions.. The mechanism of coronary artery stenosis in KD is uncertain. One possibility is acute occlusion by massive thrombus formation in the coronary aneurysms, which occur mostly in acute or subacute stages of illness. ...
The use of percutaneous coronary intervention (PCI) for unprotected left main coronary artery stenosis is increasing but it remains unclear whether this approach is non-inferior to coronary artery bypass grafting (CABG). Both the Nordic-Baltic-British left main revascularisation study (NOBLE, n=1201) and Evaluation of an everolimus eluting stent versus coronary artery bypass surgery for effectiveness of left main revascularisation study (EXCEL, n=1905) randomised patients with severe left main coronary artery stenosis to PCI or CABG to address this question. Though similar, there are important differences in these studies design and results. Primary outcomes were defined as all cause death, stroke and non-procedural myocardial infarction (MI) in both trials with the addition of repeat revascularisation in NOBLE and post-procedural MI in EXCEL. Other study differences include intended duration of follow-up, non-inferiority margins, allowable coronary complexity, and stent type. The prevalence of ...
Video 297e-30 The bifurcation lesion in the left main coronary artery extending into the LCx and LAD ostia is treated using a culotte technique. First, a drug-eluting stent is placed in the left main coronary artery and into the proximal LCx. ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Abstract. Recently conducted clinical studies prove the utility of Coronary Computed Tomography Angiography (CCTA) as a viable alternative to invasive angiography for the detection of Coronary Artery Disease (CAD). This has lead to the development of several algorithms for automatic detection and grading of coronary stenoses. However, most of these methods focus on detecting calcified plaques only. A few methods that can also detect and grade non-calcified plaques require substantial user involvement. In this paper, we propose a fast and fully automatic system that is capable of detecting, grading and classifying coronary stenoses in CCTA caused by all types of plaques. We propose a four-step approach including a learning-based centerline verification step and a lumen crosssection estimation step using random regression forests. We show state-of-the-art performance of our method in experiments conducted on a set of 229 CCTA
Then we fast forward till September 15th 1977, when Dr A Greuntzig successfully dilated an LAD stenosis in a Swiss dentist. This further proved that the goal post has moved again. That it was safe ( with all the appropriate training and precautions ) to safely work within coronary arteries. This began the journey of percutaneous coronary interventions . One by one, the goal post moved. Initially, Dr Greuntzig only advocated angioplasty ( as the new procedure was initially called ) for single lesion CAD. Then with better equipment and devices we began to do two vessels and then three vessels disease, much to the chargrin of our cardiac surgeons. The goal post was moving and still is. Coronary interventionist, ably led by the Korean Dr SJ Park and the French, Dr Jean Marco and Fajadet, began to take on left main stem disease, initially in the protected left main ( left main disease with a good functioning bypass graft ), and later in unprotected left main stem disease ( isolated ) and gradually ...
Coronary artery disease had spread in a larger number among the people worldwide. According to statistics, about 50 percent of the patients suffered from left main coronary artery stenosis. Many of the people possess the risk of the heart failure due to blockage in vessels that mainly occurs at the left main coronary artery. This Read more ...
For patients suspected of having hemodynamically significant coronary stenosis, exercise computed tomography (CT) myocardial perfusion imaging is feasible and accurate.
Among the bifurcation type, bifurcation lesion without significant side branch stenosis (,50%) usually did not require side branch stenting, but owing to several putative mechanism including dissection, thrombosis formation, embolization of plaque debris, ostial compromise by displaced stent strut, and snow plow effect, the side branch might be compromised. In this situation, the strategy to achieve optimal results has not been reported. Recently, FFR study showed that most jailed side branch (vessel size ,2.0 mm. DS,50%) after main branch stenting did not have functional significance. We compared strategies with or without routine kissing balloon dilatation for less than 50% stenosis after simple DES crossing for bifurcation lesions (bifurcation type 1.1.0, 1.0.0, and 0.1.0 according to Medina classification) with serial change of FFR measurement ...
Coronary Stenosis is that situation in which a coronary artery got lessened and backed up in the company of materials like cholesterol or fat. Coronary artery
Watch this LIVE case if you want to learn more about left main PCI, unprotected left main angioplasty strategy and distal LM bifurcation stenting.A 64-year-old male with distal LM bifurcation, LAD and LCX diseases:Two-stent techniquesIVUS assessment
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
By and For the Interventional Cardiovascular community. Sharing knowledge, experience and practice in cardiovascular interventional medicine. ...
Educators and Students: freely download thousands of medical animations and illustrations when your school library subscribes to the SMART Imagebase.
In Reply: Dr Dewey and colleagues asked about discrimination of ischemia by FFRCT vs CT. Discrimination was determined by area under the receiver operating char
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Spheric, ovoid or irregular intraluminal filling defect or lucency surrounded on three sides by contrast medium seen just distal or within the coronary stenosis in multiple projections or a visible embolization of intraluminal material downstream ...
AUM Cardiovasculars CADence System for Coronary Artery Stenosis Testing via @medgadget
This work demonstrates that the sequence of a Ge co-implant with a B,inf,2,/inf,H,inf,6,/inf, PLAD in the source/drain is very… Expand ...
TY - JOUR. T1 - Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements. AU - Cook, Christopher M.. AU - Jeremias, Allen. AU - Petraco, Ricardo. AU - Sen, Sayan. AU - Nijjer, Sukhjinder. AU - Shun-Shin, Matthew J.. AU - Ahmad, Yousif. AU - de Waard, Guus. AU - van de Hoef, Tim. AU - Echavarria-Pinto, Mauro. AU - van Lavieren, Martijn. AU - Al Lamee, Rasha. AU - Kikuta, Yuetsu. AU - Shiono, Yasutsugu. AU - Buch, Ashesh. AU - Meuwissen, Martijn. AU - Danad, Ibrahim. AU - Knaapen, Paul. AU - Maehara, Akiko. AU - Koo, Bon-Kwon. AU - Mintz, Gary S.. AU - Escaned, Javier. AU - Stone, Gregg W.. AU - Francis, Darrel P.. AU - Mayet, Jamil. AU - Piek, Jan J.. AU - van Royen, Niels. AU - Davies, Justin E.. PY - 2017/12/26. Y1 - 2017/12/26. KW - CFR. KW - coronary flow reserve. KW - coronary physiology. KW - FFR. KW - fractional flow reserve. KW - iFR. KW - instantaneous wave-free ...
The main purpose of this study is to observe the incidence of major adverse cardiac and cerebrovascular events (MACCE), target vessel failure (TVF), target vessel revascularization (TVR) and stent thrombosis out to 5 years after the procedure in patients who underwent percutaneous coronary intervention (PCI) with everolimus-eluting stents for unprotected left main coronary artery (ULMCA) disease and lesions involving the ULMCA in Japan. The investigators will also establish a method of adjustment to the Japanese version of the SYNTAX score by conducting an assessment using the SYNTAX score recently reported in the US and Europe as well as the EuroSCORE, and by clarifying the differences of PCI procedures and treatment results in Japan with those reported in the US and Europe ...
TY - JOUR. T1 - Intravascular ultrasound predictors of target lesion revascularization after stenting of protected left main coronary artery stenoses. AU - Hong, Myeong Ki. AU - Mintz, Gary S.. AU - Hong, Mun K.. AU - Pichard, Augusto D.. AU - Satler, Lowell F.. AU - Kent, Kenneth M.. AU - Popma, Jeffery J.. AU - Leon, Martin B.. PY - 1999/1/15. Y1 - 1999/1/15. N2 - We evaluated the predictors of late clinical outcomes after stenting of protected left main coronary artery (LMCA) stenoses. Intravascular ultrasound (IVUS) guided stenting of protected LMCA stenoses was performed in 87 consecutive patients between January 1994 and December 1996. Results were evaluated using conventional (clinical, angiographic, and IVUS) methodology. Late (12 month) clinical follow-up information was obtained in all patients. Initial procedural success was achieved in 86 patients (99%). There was 1 in- hospital death (in the 1 patient with a procedural failure). There were no other in-hospital complications, ...
Fractional flow reserve (FFR) is a well-validated tool for determining the functional significance of a coronary artery stenosis, facilitating clinical decisions regarding the need for revascularization. FFR-guided revascularization improves clinical and economic outcomes. However, its application remains challenging in certain complex anatomic subsets, including left main coronary artery stenosis, bifurcation disease, and saphenous vein graft disease. This article reviews recent data supporting the use of FFR in these complex anatomic subsets. [Rev Cardiovasc Med.
Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. The present analysis included the 607 patients from the FAME 2 trial (Fractional Flow Reserve Versus Angiography in Multivessel Evaluation 2) in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74±0.16), and DS (by quantitative coronary analysis) varied from 8% to 98% (average 53±15). The primary end point, defined as vessel-oriented clinical end point (VOCE) at 2 years, was a composite of prospectively adjudicated cardiac death, vessel-related myocardial infarction, vessel-related urgent, and not urgent revascularization. The stenoses were divided into 4 groups according to FFR and %DS values: positive concordance (FFR≤0.80; DS≥50%), negative concordance (FFR|0.80; DS
TY - JOUR. T1 - Performance of computed tomography-derived fractional flow reserve using reduced-order modelling and static computed tomography stress myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis. AU - Ihdayhid, Abdul Rahman. AU - Sakaguchi, Takuya. AU - Linde, Jesper J.. AU - Sørgaard, Mathias H.. AU - Kofoed, Klaus F.. AU - Fujisawa, Yasuko. AU - Hislop-Jambrich, Jacqui. AU - Nerlekar, Nitesh. AU - Cameron, James D.. AU - Munnur, Ravi K.. AU - Crosset, Marcus. AU - Wong, Dennis T.L.. AU - Seneviratne, Sujith K.. AU - Ko, Brian S.. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Aims: To compare the diagnostic performance of a reduced-order computed tomography-derived fractional flow reserve (CT-FFR) technique derived from luminal deformation and static CT stress myocardial perfusion (CTP).Methods and results: Forty-six patients (84 vessels) with suspected coronary artery disease from a single institution planned for elective coronary angiography ...
Fractional flow reserve (FFR) is a technique used in coronary catheterization to measure pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine the likelihood that the stenosis impedes oxygen delivery to the heart muscle (myocardial ischemia). FFR is a novel and potentially clinically useful mathematical solution for estimation of stenotic coronary artery atherosclerosis. Reliability/collaborative measurement between capable laboratories in measuring this essential metric appears muddled in a proprietary race to claim cardiac mathematics dedicated to risk in ischemic cardiac disease. Proprietary claims of cardiac mathematics have not been previously argued in patent law. Fractional flow reserve is defined as the pressure after (distal to) a stenosis relative to the pressure before the stenosis. The result is an absolute number; an FFR of 0.80 means that a given stenosis causes a 20% drop in blood pressure. In other words, FFR expresses the ...
Diabetes mellitus (DM), low ejection fraction (EF), and the extent of coronary artery disease (CAD) have all been identified as predictors of cardiovascular eve...
Methods and Results-Using intracoronary measurements, 91 coronaries (78 patients) with intermediate stenoses were classified in 4 FFR and coronary flow reserve (CFR) agreement groups, using FFR,0.80 and CFR,2 as cutoffs. Index of microcirculatory resistance (IMR) and atherosclerotic burden (Gensini score) were also assessed. MCD was assumed when IMR≥29.1 (75th percentile). Fifty-four (59.3%) vessels had normal FFR, from which only 20 (37%) presented both normal CFR and IMR. Among vessels with FFR,0.80, most (63%) presented disturbed hemodynamics: abnormal CFR in 28 (52%) and MCD in 18 (33%). Vessels with FFR,0.80 presented higher IMR [adjusted mean 27.6 (95% confidence interval, 23.4-31.8)] than those with FFR≤0.80 [17.3 (95% confidence interval, 13.0-21.7), p=0.001]. Atherosclerotic burden was inversely correlated with CFR (r=−0.207,P=0.055), and in vessels with FFR,0.80 and CFR,2 (n=28, 39%), IMR had a wide dispersion (7-72.7 U), suggesting a combination of diffuse atherosclerotic ...
OBJECTIVE To compare the consistency of angiography-guided and fractional flow reserve (FFR)-guided management strategy for intermediate coronary lesions. METHODS The patients whose coronary intermediate lesions were assessed by measuring FFR from November 2012 to August 2014. The stenosis percentage and value of FFR during the procedure were collected. All the image data were collected and four experienced interventional cardiologists were invited to assess the target lesions and make a management strategy independently. The consistency of angiography-guided and fractional flow reserve-guided management strategy were analyzed. RESULTS In the study, 151 patients were included, of whom, 70.2% were male, the average age was (62.7±9.6) years, 169 vessels were assessed by measuring FFR, 1 being left main, 116 left anterior descending, 27 left circumflex branch, and 25 right coronary artery. There were some correlationship between the stenosis percentage judged by four interventional cardiologists and
TY - JOUR. T1 - The long-term clinical outcome of T-stenting and small protrusion technique for coronary bifurcation lesions. AU - Naganuma, Toru. AU - Latib, Azeem. AU - Basavarajaiah, Sandeep. AU - Chieffo, Alaide. AU - Figini, Filippo. AU - Carlino, Mauro. AU - Montorfano, Matteo. AU - Godino, Cosmo. AU - Ferrarello, Santo. AU - Hasegawa, Tasuku. AU - Kawaguchi, Masanori. AU - Nakamura, Sunao. AU - Colombo, Antonio. PY - 2013/6. Y1 - 2013/6. N2 - Objectives This study sought to report long-term clinical outcomes in patients treated with the provisional T-stenting and small protrusion (TAP) technique. Background Several strategies have been proposed for treating bifurcation lesions, each with its own merits and technical challenges. The TAP technique is a relatively new strategy that is technically less challenging, ensures complete coverage of the side-branch ostium, and minimizes stent overlap. Although there is reasonable amount of data for other bifurcation strategies, the long-term ...
Evidence-based recommendations on QAngio XA 3D QFR and CAAS vFFR imaging software for assessing coronary stenosis during invasive coronary angiography
Second generation drug-eluting stents are safe and effective in treatment of left main coronary artery disease. A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the worlds premier educational meeting specializing in interventional cardiovascular medicine.. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often considered at high-risk of adverse cardiovascular events. The use of first generation drug-eluting stents in these lesions has previously been shown to be feasible, safe, and effective. The second-generation zotarolimus-eluting (ZES) and everolimus-eluting stents (EES), used more widely in clinical practice at present, perform very similarly in ...
In the present study, we compared the prognostic impact of treatment strategy on clinical outcomes according to bifurcation lesion location (LM vs. non-LM bifurcation lesion) using data from a large, multicenter, dedicated bifurcation registry. The main findings of the present study are that compared with the 1-stent strategy, the 2-stent strategy was associated with higher risks of cardiovascular events in patients with LM bifurcation lesion, whereas this association was attenuated in those with non-LM bifurcation lesions, and that significant interactions were present between treatment strategy and bifurcation lesion location in the adjusted risks of target lesion failure, target lesion revascularization, and target vessel revascularization.. Coronary bifurcation lesions are complex, and their treatment continues to be the subject of substantial debate, even in the DES era (1,2). Previous randomized trials comparing the 1-stent strategy with the elective 2-stent strategy (mainly in patients ...
OBJECTIVES: The aims of the present study were to investigate the applicability of quantitative flow ratio (QFR) in patients with 3-vessel disease and to demonstrate the impact of functional SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score derived from QFR (fSSQFR) on clinical outcomes. BACKGROUND: The applicability of QFR in patients with 3-vessel disease and the feasibility of fSSQFR have not yet been investigated. METHODS: All lesions interrogated using instantaneous wave-free ratio and/or fractional flow reserve in the SYNTAX II trial were retrospectively screened and analyzed for QFR. The diagnostic performance of QFR was investigated using hybrid wire-derived pressure assessment (instantaneous wave-free ratio and fractional flow reserve), used in the trial as a reference. Patients with analyzable QFR in 3 vessels were stratified according to fSSQFR to evaluate its clinical prognostic value on the basis of 2-year patient-oriented composite endpoint.
Intracoronary transluminal attenuation gradient in coronary CT angiography for determining coronary artery stenosis Academic Article ...
ST. PAUL, Minn.--(BUSINESS WIRE)--St. Jude Medical, Inc. (NYSE: STJ), a global medical device company, today announced its wireless PressureWire™ Aeris technology, which aids in the diagnosis and treatment of coronary artery blockages by measuring Fractional Flow Reserve (FFR), will now be available to hospitals using the Philips Xper Flex Cardio physiomonitoring system. Physicians will have greater access to the markets only wireless FFR measurement system through this new Philips agreement. FFR measurements indicate the severity of blood flow blockages in the coronary arteries, allowing physicians to better identify which specific lesion or lesions are responsible for a patients ischemia, a deficiency of blood supply to the heart caused by blood flow restriction. The PressureWire Aeris technology helps physicians determine the best treatment options for patients during coronary interventions, such as stent procedures. The PressureWire Aeris system offers a secure, wireless interface between ...
In this study, beta-blockade blunted the ischemic response to dobutamine stress, an effect only partially eliminated by atropine. Importantly, this study also provided hemodynamic and biochemical correlates of this phenomenon and demonstrated that beta-blockade causes a shift in the relation between regional wall thickening and coronary flow per heartbeat.. Dobutamine stress in the non-beta-blocked state. This study confirmed the results of previous clinical (3,9) and experimental studies (20), in that incremental doses of dobutamine induce a characteristic biphasic pattern in wall thickening in regions supplied by significant coronary artery stenosis but without baseline regional wall motion abnormalities. This consisted of an initial increase in wall thickening at low doses of dobutamine, with subsequent significant decreases in wall thickening to or below baseline values at higher doses. In contrast, in normally perfused regions, regional wall thickening increased significantly at low doses ...
This cross-sectional study evaluates the association of major adverse cardiac events (MACE) integrated with fractional flow reserve as the management strategy f
The Heart (Function (The left main coronary artery, on one side of the…: The Heart (Function, Facts (The heart pumps about 6 quarts (5.7 liters) of blood throughout the body, The heart beats about 100,000 times per day (about 3 billion beats in a lifetime), An adult heart beats about 60 to 80 times per minute, The heart weighs between about 10 to 12 ounces (280 to 340 grams) in men and 8 to 10 ounces (230 to 280 grams) in women, Newborns hearts beat faster than adult hearts, about 70 to 190 beats per minute, A human heart is roughly the size of a large fist, The heart is located in the center of the chest, usually pointing slightly left ), Anatomy (Two lower chambers (the ventricles), The right atrium and right ventricle together make up the right heart, Two upper chambers (the atria), The left atrium and left ventricle make up the left heart, The physiology of the heart comes down to structure, electricity and plumbing , A double-walled sac called the pericardium encases the heart, which serves
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Assessment of myocardial blood volume changes during adenosine using MCE can be used for the determination of the functional relevance of coronary stenoses of intermediate angiographic severity if MVO2 is increased during adenosine.
To the best of our knowledge, this is the only prospective, randomized study with long-term results at 7 years in patients with isolated lesions of the proximal LAD treated by either PCI with SES or MIDCAB surgery. There were no significant differences in the composite primary endpoint and individual hard endpoints such as cardiac death and myocardial infarction between PCI with SES and MIDCAB. However, TVR was more frequent with PCI.. Current guidelines for revascularization of stable coronary artery disease recommend a stop of the procedure and discussion of further therapy with the patient and the heart team, after the discovery of an isolated proximal LAD stenosis. In American guidelines, revascularization in patients with single-vessel disease and an isolated proximal LAD stenosis PCI has a Class IIb Level of Evidence: B recommendation and surgery with left internal mammary artery a Class IIa B recommendation, whereas in European guidelines PCI has a Class IIa Level of Evidence: B ... Physiological Assessment of Coronary Stenoses and the Microcirculation (9781447152446) and a great selection of similar New, Used and Collectible Books available now at great prices.
Relationship between epicardial adipose tissue volume measured using coronary computed tomography angiography and atherosclerotic plaque characteristics in patients with severe coronary artery stenosis Journal Article published 17 Sep 2013 in Journal of International Medical Research volume 41 issue 5 on pages 1520 to 1531 Authors: Dan-Dan Dong, Kai Wang, Dan Wang, Tong Zhang, Ying-Feng Tu, Bao-Zhong Shen. ...
BACKGROUND: The value of angiographic follow-up in unprotected left main (ULM) stenting remains undefined. METHODS: The FAILS-2 registry included consecutive patients presenting with a critical lesion of an ULM treated with second generation drug eluting stents in 6 centers from June 2007 to January 2015. Patients were stratified into two groups: those discharged with planned angiographic follow-up and those with clinical follow-up. MACE (Major Adverse Clinical Events, a composite end point of death, myocardial infarction, TLR, and ST) was the primary end point, while each component was a secondary endpoint Sensitivity analysis was performed for patients treated with a provisional or a two-stent strategy ...
BACKGROUND: Postoperative myocardial injury (PMI) is a strong predictor of mortality after noncardiac surgery. PMI is believed to be attributable to coronary artery disease (CAD), yet its etiology is largely unclear. We aimed to quantify the prevalence of significant CAD in patients with and without PMI using coronary computed tomography angiography (CCTA). METHODS: This prospective cohort study included patients of 60 years or older without a history of cardiac disease and with and without PMI after intermediate- to high-risk noncardiac surgery. PMI was defined as any serum troponin I level ≥60 ng/L on the first 3 postoperative days. Main exclusion criteria were known cardiac disease and postoperative ischemic symptoms or electrocardiography abnormalities. Noninvasive imaging consisted of a postoperative CCTA. Main outcome was CAD defined as >50% coronary stenosis on CCTA. RESULTS: The analysis included 66 patients. Median peak troponin levels in the PMI (n = 46) and control group (n = 20) ...
A method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed. In one embodiment, medical image data of the patient including the stenosis
Coronary CT angiography (CCTA) identified plaques in acute MI patients whose coronary angiograms did not produce evidence of significant coronary stenosis.
If we think we have unraveled all the mysteries of human coronary blood flow we are sadly mistaken . Most cardiac physicians spend their prime life in opening the obstructed coronary arteries playing a role of coronary plumber. Like any plumber , it is not going to be one time job and our patients …
A new study clarifies that statins are the greatest medical fraud of all time. The claims made for them are false. The amount of harm they do is staggering, resulting in millions of lives devastated and ended. The worst part of all, though, is that it was entirely predictable-but studies were designed to hide the truth. The media, the health agencies, and the doctors all provided cover for Big Pharma. After all, there was money to be made.. ...
Left main ostial lesion remains a challenging task .A new stent design is proposed here. The lesion The hardware The technique Final message This thought came when I recently encountered a patient with a left main ostial stent which was projecting well into aortic root .It is an open access patency ,whoever is capable of…
I was wondering if anyone knows why FFR (Fractional flow reserve) isnt used in all cath labs? I read about a good example last year where a man was having a heart attack. In the Cath lab they used FFR...
The vascular system can be damaged from cocaine abuse. Arterial thrombosis, coronary stenosis are just two of some of the harmful effects that can be caused abd cause a person to have a stroke. See how this can happen.
We prospectively analyzed all consecutive patients treated at our center for bifurcation lesions from 2011-2015 and compared the angiographic and clinical outcomes of patients with left main bifurcation lesions vs those with non-left main bifurcation ...
I think he is saying NT or angi or something. I cannot tell. This is in the area of her abdomen and she is being seen for not having bowel movements for two days ...
If serial stenoses are less than 3 vessel reference diameters apart, they should be scored as one lesion. However, stenoses at a greater distance from each other (more than 3 vessel reference diameters), are considered as separate lesions ...
ACIST Medical Systems - US - Advancing diagnostic assessments with Rapid FFR The ACIST RXi® system combines accurate and reliable FFR measurements with the advantages of Rapid Exchange technology.
"Evaluation of transluminal angioplasty of chronic coronary artery stenosis. Value and limitations assessed in fresh human ... Atherosclerosis Peripheral artery disease Peripheral vascular disease Stenosis Systemic circulation Thrombosis "What Is ...
... showing luminal stenosis in coronary artery atherosclerosis. "Pathology News: Newsletter, Vol. 3, No. 4: April ...
"Percutaneous transluminal angioplasty for shepherd's crook right coronary artery stenosis". Catheterization and Cardiovascular ... In medicine, the term shepherd's crook is used to describe a right coronary artery that follows an unusually high and winding ... and Classifying Congenital Anomalies of the Coronary Arteries". RadioGraphics. 32 (2): 453-468. doi:10.1148/rg.322115097. ISSN ...
"Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis". PLOS ONE. 7 (8): e43378. Bibcode:2012PLoSO ... "Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women". Circulation ...
CAST system is available for the detection of significant (>50%) coronary stenosis in coronary CT angiography (cCTA) studies. ... Halpern, EJ; Halpern, DJ (March 2011). "Diagnosis of coronary stenosis with CT angiography comparison of automated computer ... May 2010). "Automated computer-aided stenosis detection at coronary CT angiography: initial experience". Eur Radiol. 20 (5): ... April 2012). "Feasibility of an automatic computer-assisted algorithm for the detection of significant coronary artery disease ...
Coronary Thrombosis among Women. Am J M Sc. 1938; 196: 815-818 Ingham, D.W. and F.A. Willius. Congenital Transposition of the ... Interpretation of the Electrocardiographic Findings in Calcareous Stenosis of the Aortic Valve. Ann Intern Med. 1939;13(1):143- ... Coronary Thrombosis Among Persons Less Than Forty Years of Age; a Study of Thirty Cases. Minnesota Medicine, St. Paul. 1939;33: ... Tobacco and Coronary Disease. JAMA. 1940;115(16):1327-1329. Willius, F.A. and T.J. Dry. The Prognosis of Auricular Fibrillation ...
... , namely coronary ostial stenosis, is the occlusion of coronary ostium. Causing factors include atherosclerosis, ... Angelini, P (2012). "Congenital Coronary Artery Ostial Disease". Tex Heart Inst J. 39 (1): 55-9. PMC 3298900. PMID 22412228. ( ...
Coronary angiography can visualize coronary artery stenosis, or narrowing of the blood vessel. The degree of stenosis can be ... Any stenoses found may be treated by the use of balloon angioplasty, stenting, or atherectomy. Fluorescein angiography is a ... One of the most common angiograms performed is to visualize the blood in the coronary arteries. A long, thin, flexible tube ... X-ray images of the transient radiocontrast distribution within the blood flowing inside the coronary arteries allows ...
ISBN 978-1-4471-6581-1 Farkouh M, Sharma S, Tomey M, Puskas J, Fuster V. Coronary artery bypass grafting and percutaneous ... Samin Sharma of Mount Sinai is an expert at treating aortic stenosis". Retrieved 2020-05-29. "Experts Say ... "Mount Sinai Hospital Earns Highest Ratings in New York State Report on Coronary Angioplasty". Retrieved 2022-04- ... In 2009, he performed a coronary angiography and angioplasty procedure on Indian Prime Minister Shri Manmohan Singh. As of 2022 ...
66-8 stenosis of the left pulmonary artery, in 40% a bicuspid pulmonary valve, in 60% right-sided aortic arch, in 25% coronary ... Acquired mitral valve stenosis symptoms also include a wide array such as consciousness losses, angina, general weakness and ... Congenital Mitral valve stenosis symptoms include a wide array such as respiratory infections, breathing difficulties, heart ... This open-heart surgery is designed to relieve the right ventricular outflow tract stenosis by careful resection of muscle and ...
... coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple ... Overall, this leads to relaxation of the smooth muscle and coronary vasodilation. The effect of nicorandil as a vasodilator is ... Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic ... In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations. At high plasma ...
Had mitral valve stenosis (shrunk) and regurgitation (leaking) and aortic valve stenosis (shrunk). Had robotic double valve ... Patient had coronary artery disease and severe mitral valve leak. Patient had combined robotic mitral valve replacement and ... Patient had aortic valve stenosis (shrunk) and regurgitation (leak) with reduced pumping of the heart. He underwent robotic ... coronary artery bypass surgery. India's first Robotic Aortic Valve Replacement, 2010. 18-year-old patient with complaints of ...
May 2007). "Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study". J ... June 1996). "Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses". N. Engl. J ... FFR measures pressure differences across a coronary artery stenosis (narrowing, usually due to atherosclerosis) to determine ... FFR has certain advantages over other techniques to evaluate narrowed coronary arteries, such as coronary angiography, ...
Romagnoli E, Niccoli G, Crea F (October 2005). "Images in cardiology: A coronary organic stenosis distal to severe, ergonovine ... It can induce spasm of the coronary arteries. It is used to diagnose variant (Prinzmetal's) angina. Possible side effects ... Sunagawa O, Shinzato Y, Touma T, Tomori M, Fukiyama K (May 2000). "Differences between coronary hyperresponsiveness to ...
Coronary Artery Disease (CAD) results from the stenosis of coronary arteries by an atherosclerotic plaque. The coronary ... "Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review". The Journal of ... "Coronary heart disease". 2018-10-03. Retrieved 2022-03-20. Zemaitis MR, Boll JM, Dreyer MA (2022). "Peripheral Arterial ... A myocardial infarction (MI), or heart attack, arises from complete occlusion of a coronary artery. The most frequent cause of ...
Fractional flow reserve (FFRmyo): Testing the blood flow through a stenosis of a coronary artery to determine the perfusion of ... Coronary artery disease (CAD)- Coronary artery disease is a general term for any reduction in coronary circulation. One such ... Aortic stenosis - Narrowing of the aortic valve opening that reduces blood flow through the valve. Stenosis commonly occurs ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ...
"Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. ...
They are used to treat bone fractures, osteoarthritis, scoliosis, spinal stenosis, and chronic pain. Examples include a wide ... and coronary stent. Orthopaedic implants help alleviate issues with the bones and joints of the body. ...
This formula is used to study the severity of aortic valve stenosis and mitral valve stenosis. Gorlin was a very early pioneer ... In addition, he was one of the first to recognize that significant left main coronary artery disease was a dire prognostic ... developed the Gorlin formula used to calculate valve areas in aortic valve stenosis and mitral valve stenosis. Gorlin was born ... He was also one of the first to describe angina pectoris in patients without obstructive coronary artery disease, also now ...
"Exercise-induced U-wave inversion as a marker of stenosis of the left anterior descending coronary artery". Circulation. 60 (5 ... The U wave is the momentum carried by the blood in the coronary arteries and blood vessels. It is possible to take this ... According to V. Gorshkov-Cantacuzene: "The U wave is the momentum carried by the blood in the coronary arteries and blood ... This idea is also proved by the fact that hypertrophy of the left ventricle, myocardial ischemia, coronary and insufficiency ...
Therefore, IRE has been suggested as preventive treatment for coronary artery re-stenosis after percutaneous coronary ...
"Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute ... However, the idea of coronary artery vasospasm is still believed to contribute to the TTS disease process. The theory of ... The condition is thought to be responsible for 2% of all acute coronary syndrome cases presenting to hospitals. Although TTS ... Zamir, M. (2005). The Physics of Coronary Blood Flow. Springer Science and Business Media. p. 387. ISBN 978-0387-25297-1. "Mayo ...
He suffered from aortic stenosis, and died of a coronary occlusion in his home in Hawthorn, aged 59. Oscar Tiegs' scientific ...
Recurrence of FPE is thought to be associated with hypertension and may signify renal artery stenosis. Prevention of recurrence ... is based on managing or preventing hypertension, coronary artery disease, renovascular hypertension, and heart failure. There ...
Carotid artery stenosis is a major risk factor for stroke, and risk assessment of atherosclerotic carotid plaques is a critical ... Contraindications to the ultrasound contrast include allergy, heart failure, acute coronary syndrome, endocarditis, ventricular ... B-mode ultrasound is able to assess the structure of the carotid arteries and can identify areas of stenosis. B-mode is used ... It is most often used to diagnose carotid artery stenosis, a form of atherosclerosis, and has the capability to assess plaque ...
In particular in cases when the degree of stenosis of a coronary artery is unclear, IVUS can directly quantify the percentage ... The arteries of the heart (the coronary arteries) are the most frequent imaging target for IVUS. IVUS is used in the coronary ... In the early 1990s, IVUS research on the re-stenosis problem after angioplasty lead to recognition that most of the re-stenosis ... Only 14% of heart attacks occurred at locations with 75% or more stenosis[citation needed], the severe stenoses previously ...
... can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems, or a ... Ventricular tachycardia can occur due to coronary heart disease, aortic stenosis, cardiomyopathy, electrolyte problems (e.g., ...
Coronary artery blockages or stenoses that limit blood flow to the heart muscle can cause angina and can be treated by stenting ... Instantaneous wave-free ratio is performed using high fidelity pressure wires that are passed distal to the coronary stenosis. ... is a diagnostic tool used to assess whether a stenosis is causing a limitation of blood flow in coronary arteries with ... using invasive coronary pressure wires which are placed in the coronary arteries that are to be assessed. Pressure wires are ...
Less than 20% of all cases of chest pain admissions are found to be due to coronary artery disease. The rate of chest pain as a ... Aortic stenosis: This condition happens when the person has underlying congenital bicuspid valve, aortic sclerosis, or history ... If acute coronary syndrome ("heart attack") is suspected, many people are admitted briefly for observation, sequential ECGs, ... Acute coronary syndrome Stable or unstable angina Myocardial infarction ("heart attack"): People usually complained of a ...
He described a type of aortic stenosis which was not rheumatic in origin, and described effort syncope in the condition. He ... studied angina pectoris, describing the syndrome in Les Angines de Poitrine in 1925; he maintained the belief that coronary ...
433.0 Occlusion and stenosis of basilar artery 433.1 Occlusion and stenosis of carotid artery 433.2 Occlusion and stenosis of ... 414.11 Aneurysm of coronary vessels 414.12 Dissection of coronary artery 414.8 Ischemic heart disease, chronic, other 414.9 ... 440 Atherosclerosis 440.1 Stenosis of renal artery 440.2 Peripheral Arterial Disease 440.21 Peripheral Arterial Disease with ... 392 Rheumatic chorea 393 Chronic rheumatic pericarditis 394 Diseases of mitral valve 394.0 Mitral stenosis 394.1 Rheumatic ...
... and/or one of its CMTM5 proteins may promote atherosclerosis-based coronary artery disease and the stenosis of coronary artery ... Liu TF, Lin T, Ren LH, Li GP, Peng JJ (December 2020). "[Association between CMTM5 gene and coronary artery disease and the ... They found that high blood plasma levels of CMTM5 mRNA were associated with a higher rate of subsequently developing stenosis ( ... to determine if expression of the CMTM5 gene's or its products can be used as makers for patient susceptibilities to coronary ...
In particular, he worked on the criteria of arterial stenosis of limbs and carotids, Carotid pre-thrombosis, the Pressure- ... and completing Coronary artery bypass surgery, more and more necessary for the aging population. Several randomized controlled ... This data remains the undisputed reference for the stenosis quantification and a quality diagnostic. ...
... syndactyly jejunal atresia Coronaro-cardiac fistula Coronary arteries congenital malformation Coronary artery aneurysm Coronary ... disorder Congenital skin disorder Congenital spherocytic anemia Congenital spherocytic hemolytic anemia Congenital stenosis of ... neuropathy Cervical hypertrichosis peripheral neuropathy Cervical ribs sprengel anomaly polydactyly Cervical spinal stenosis ... Congenital mesoblastic nephroma Congenital microvillous atrophy Congenital mitral malformation Congenital mitral stenosis ...
... examines the pressure drop across the stenosis in suspected ischemic coronary artery that may require percutaneous coronary ... A coronary CT calcium scan is a computed tomography (CT) scan of the heart for the assessment of severity of coronary artery ... Coronary angiography is used to determine the patency and configuration of the coronary artery lumens. Intravascular ultrasound ... "Assessment of Agatston Coronary Artery Calcium Score Using Contrast-Enhanced CT Coronary Angiography". American Journal of ...
"Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech ... such as diverticulitis and acute coronary syndrome. Diagnosis of late-stage Lyme disease is often complicated by a multifaceted ...
Angina Acute coronary syndrome Anomic aphasia Aortic dissection Aortic regurgitation Aortic stenosis Apoplexy Apraxia ... Valvular heart disease Aortic insufficiency Mitral stenosis Tricuspid valve stenosis Pulmonary valve stenosis Mitral ... Pulmonary stenosis (critical) Atrial septal defect Ventricular septal defect Patent ductus arteriosus and Coarctation of aorta ... may cause cyanosis in some cases) See also Category:Ischemic heart diseases Angina pectoris Acute coronary syndrome Acute ...
These comorbidity conditions include aortic aneurysm, aortic stenosis, extensive three-vessel coronary artery disease, diabetes ... Coronary angiography is a diagnostic procedure that allows visualization of the coronary vessels. Fluoroscopy is used to ... A common example of cardiac catheterization is coronary catheterization that involves catheterization of the coronary arteries ... Acute coronary syndromes: ST elevation MI (STEMI), non-ST Elevation MI (NSTEMI), and unstable angina Evaluation of coronary ...
While a single ruptured plaque can be identified during autopsy as the cause of a coronary event, there is currently no way to ... Because artery walls typically enlarge in response to enlarging plaques, these plaques do not usually produce much stenosis of ... Some of the CT derived plaque characteristics can help predict for acute coronary syndrome. In addition, because these lesions ... The clot organizes and contracts over time, leaving behind narrowing(s) called stenoses. These narrowing(s) are responsible for ...
Pyloric stenosis, infantile hypertrophic, 2 ITFG3: encoding protein Protein ITFG3 KDM8: encoding protein Lysine demethylase 8 ... Coronary heart disease, susceptibility to, 1 CIAPIN1: Anamorsin (originally, Cytokine induced apoptosis inhibitor 1) CKLF: ...
This is often used by cardiologists to determine if a coronary stenosis should be treated either by angioplasty or coronary ... one or more of the coronary arteries that has been previously identified either by standard coronary angiography or CT coronary ... be further investigated with another imaging modality to directly image the coronary arteries such as invasive coronary ... To screen patients who have chest pain and risk factors for coronary artery disease, to assess for ischaemia which may be ...
Coronary CT angiography (CCTA) is the use of CT angiography to assess the arteries of the heart. The patient receives an ... Stenosis (narrowing) of a renal artery is a cause of hypertension (high blood pressure) in some patients and can be corrected. ... While CTA can produce high quality images of the carotid arteries for grading the level of stenosis (narrowing of the vessel), ... Varying significantly with patient age, sex, and exam protocol, radiation risk models predict coronary CTA to increase lifetime ...
AF in the context of mitral stenosis is associated with a seventeenfold increase in stroke risk. If anticoagulation is required ... results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at ... mitral stenosis) and on the presence of other risk factors, such as diabetes and high blood pressure. Finally, patients under ... a randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long- ...
Patients who could benefit from AAC or AVB include those who:[citation needed] Have had coronary artery bypass surgery and have ... Treatment of aortic stenosis with aortic valve bypass (apicoaortic conduit) surgery: An assessment using computational modeling ... Today, AAC is performed clinically on elderly aortic stenosis patients, and has gained in popularity in recent years. In the ... Left ventricular outflow tract obstruction (LVOTO) is caused by narrowing of the aortic valve (aortic stenosis) and other valve ...
Similar to coronary artery stenting procedures, this is accessed via a small incision in the groin, through which the delivery ... Severe symptomatic aortic stenosis carries a poor prognosis. At present there is no treatment via medication, making the timing ... The device is effective in improving functioning in patients with severe aortic stenosis. It is now approved in more than 50 ... Patients with symptomatic severe aortic stenosis have a mortality rate of approximately 50% at 2 years without intervention. In ...
Stenosis severity and extent of coronary artery disease are important prognostic indicators. However, one of the unique ... 2012). "Quantification of coronary stenosis by dual source computed tomography in patients: a comparative study with ... Coronary CT angiography (CTA or CCTA) is the use of computed tomography (CT) angiography to assess the coronary arteries of the ... It may be useful in the diagnosis of suspected coronary heart disease, for follow-up of a coronary artery bypass, for the ...
Genome-wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis. PLoS ... PLoS ONE, 2013;8(1). 3. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics ... Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis ... Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease. PLoS One. 2011;6(12) 8. ...
An example of cardiac surgery is coronary bypass surgery. The primary goals of this specialty include increasing endurance and ... Wise J (April 2015). "Physical therapy is as effective as surgery for lumbar spinal stenosis, study finds". BMJ. 350: h1827. ... Pulmonary disorders, heart attacks, post coronary bypass surgery, chronic obstructive pulmonary disease, and pulmonary fibrosis ... controlled study has shown that surgical decompression treatment and physiotherapy are on par for lumbar spinal stenosis in ...
High frequency analysis of the QRS complex may be useful for detection of coronary artery disease during an exercise stress ... rate at the end of exercise is critical to improving the sensitivity of the test to detect high grade heart artery stenosis. ... to assess the evolution of coronary artery disease and evidence of existing damage. A great many more physiologic markers ... Cardiac imaging techniques include coronary catheterization, echocardiogram, intravascular ultrasound, retinal vessel analysis ...
... pulmonary stenosis and mitral stenosis. The department has modern equipment and provides a complete array of routine and ... Diagnostic coronary angiography Right and left heart catheterization Coronary angioplasty with stent implantation Implantation ... Some of the publications done by the doctors of MIC include the following: Right Ventricular Dysfunction after Coronary Artery ... The types of surgeries offered include: • Coronary artery bypass surgery. • Valve replacements and repair • Surgery for aortic ...
The repairing process of the artificial heart valve regurgitation and stenosis usually requires an open-heart surgery, and a ... coronary arteries, leading to heart attack [myocardial infarction]; or cerebral arteries, leading to stroke). A desirable ... stenosis) and/or let blood flow backwards through the valve (regurgitation). Both processes put strain on the heart and may ...
... referred to as percutaneous coronary intervention or angioplasty, involves placing a stent at the site of stenosis in an artery ... Another surgical intervention is coronary artery bypass. Coronary artery vasospasm Raynaud's phenomenon, a vasospastic disorder ... in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary ... Ischemia in the heart due to prolonged coronary vasospasm can lead to angina, myocardial infarction and even death. Vasospasm ...
... a diagnostic medical test used in coronary artery stenosis assessment This disambiguation page lists articles associated with ...
This is well known to thoracic surgeons: a vein removed to bypass a coronary artery and grafted into the artery position ... The pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and ...
... tricuspid valve stenosis, pulmonary valve stenosis and aortic valve stenosis. Stenosis of the mitral valve is a common ... The heart also has a coronary sinus valve, and an inferior vena cava valve, not discussed here. The heart valves and the ... This is a result of the valve becoming thickened and any of the heart valves can be affected, as in mitral valve stenosis, ... For example, valvular disease of the aortic valve, such as aortic stenosis or aortic regurgitation, may cause breathlessness, ...
Renal artery stenosis (RAS) may be associated with a localized abdominal bruit to the left or right of the midline (unilateral ... Long-term high blood pressure, however, is a major risk factor for stroke, coronary artery disease, heart failure, atrial ... renal artery stenosis, coarctation of the aorta, and primary aldosteronism. As many as one in five people with resistant ... renal artery stenosis (from atherosclerosis or fibromuscular dysplasia), hyperparathyroidism, and pheochromocytoma. Other ...
Ischemic heart disease develops when stenosis and occlusion of coronary arteries develops, leading to reduced perfusion of the ... Lassaletta, Antonio D.; Chu, Louis M.; Sellke, Frank W. (November 2011). "Therapeutic neovascularization for coronary disease: ...
Patients with moderate aortic valve stenosis who need another type of cardiac surgery (i.e. coronary artery bypass surgery) ... Aortic stenosis most commonly is the result of calcification of the cusps. Other reasons for stenosis are the bicuspid valve ( ... The origins of the two coronary arteries are sited in two Valsalva sinuses, each named after the coronary artery they supply. ... In cases of symptomatic severe aortic stenosis, AVR is warranted. In cases of asymptomatic but severe aortic stenosis, more ...
This caused mitral stenosis, an abnormal narrowing of the mitral valve in the heart. Conway became too ill to stay at home, and ... and damaged his coronary valves. He was not told to seek treatment, and continued working. Groom had always enjoyed singing, ...
Coronary artery disease is caused when coronary arteries of the heart accumulate atheromatic plaques, causing stenosis in one ... Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage") is a surgical procedure ... The best modalities to accurately detect CAD though are the coronary angiogram and the Coronary CT angiography. Angiogram can ... Severe stenosis is considered when the diameter loss is 2/3 of original diameter or more, that is 90% loss of cross-sectional ...
Among symptomatic patients with medically treated moderate-to-severe aortic stenosis, mortality from the onset of symptoms is ... Aortic stenosis is the obstruction of blood flow across the aortic valve (see the image below). ... Cardiac Catheterization and Coronary Arteriography. Cardiac catheterization provides an accurate measure of aortic stenosis and ... Generally, the incidence of associated coronary artery disease has been reported to be 50% in patients with aortic stenosis who ...
142 Studies found for: Recruiting Studies , Coronary Stenosis. Also searched for Heart, Constriction, Coronary artery stenosis ...
The data signal coronary imagings shift in focus from stenosis to coronary plaque. ... Contrast-enhanced 64-slice CT can accurately detect and characterize atherosclerotic coronary lesions, according to a study ... The data signal coronary imagings shift in focus from stenosis to coronary plaque. ... The data signal coronary imagings shift in focus from stenosis to coronary plaque. ...
... we performed standardized contrast injection of the contralateral coronary artery in 58 consecutive patients, without previous ... To determine the factors that influence the presence of collateral vessels during coronary occlusion, ... Severity of single-vessel coronary arterial stenosis and duration of angina as determinants of recruitable collateral vessels ... right coronary artery: in 10 and left circumflex artery in 3). The presence of collateral vessels during coronary occlusion, ...
Study of angiographic association of atherosclerotic renal artery stenosis with coronary artery disease in Bangladesh Authors. ... A total of 250 patients with coronary artery involvement, on non-emergent coronary angiogram who underwent either selective or ... Study of angiographic association of atherosclerotic renal artery stenosis with coronary artery disease in Bangladesh. ... ARAS prevalence increased with the number of stenosed coronary arteries (3.8% in 1-vessel, 26.5% in 2-vessel, 52.3%in 3-vessel ...
Guidewire navigation in coronary artery stenosis using a novel magnetic navigation system: First clinical experience. ... The objective of this study was to investigate the efficacy of guidewire navigation across coronary artery stenoses using ... Guidewire navigation in coronary artery stenosis using a novel magnetic navigation system: First clinical experience. ... Clinical studies are needed to evaluate the potential benefit of the MNS in more complex coronary lesions and tortuous anatomy. ...
Arbab-Zadeh, A & Hoe, J 2011, Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with ... Arbab-Zadeh A, Hoe J. Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with ... T1 - Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with conventional angiography ... Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with conventional angiography: ...
Computerized two-lead resting ecg analysis for the detection of coronary artery stenosis after coronary revascularization. Int ... stenosis of 50% or less. The location of stenosis was defined as the following: proximal for lesions in the right coronary ... to quantitative coronary angiography for the detection of relevant coronary artery stenosis (,70%)-a meta-analysis of all ... stenosis in a proximal lesion, or 99% stenosis in a distal lesion; level 2 (mild), 75-90% stenosis in a distal lesion; and ...
Among symptomatic patients with medically treated moderate-to-severe aortic stenosis, mortality from the onset of symptoms is ... Aortic stenosis is the obstruction of blood flow across the aortic valve (see the image below). ... Cardiac Catheterization and Coronary Arteriography. Cardiac catheterization provides an accurate measure of aortic stenosis and ... Generally, the incidence of associated coronary artery disease has been reported to be 50% in patients with aortic stenosis who ...
Tewari S, Roy S, Kapoor A, Sinha N. Isolated left main coronary ostial stenosis in a young female. Journal of the Association ...
Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses. Umamahesh C. Rangasetty, ... Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses. / Rangasetty, Umamahesh C.; ... Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses. Journal of the American ... title = "Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses",. author = " ...
CHD congestive heart disease; coronary heart disease; congenital heart disease; Chediak-Higaski Disease ... IHSS idiopathic hypertrophic subaortic stenosis. IIAC idiopathic infantile arterial calcification. ILD interstitial lung ...
Coronary Artery Disease. Aortic Valve Stenosis. Coronary Disease. Myocardial Ischemia. Heart Diseases. Cardiovascular Diseases ... patients with aortic valve stenosis and coronary heart disease with indication for AVR and CABG ... In procedures where the aortic valve replacement (AVR) is combined with a coronary artery bypass graft (CABG), the use of a ... MedlinePlus Genetics related topics: Supravalvular aortic stenosis Genetic and Rare Diseases Information Center resources: ...
Supravalvular mitral ridge containing the dominant left circumflex coronary artery. J Thorac Cardiovasc Surg. 1981 Apr. 81(4): ... encoded search term (Supravalvular Ring Mitral Stenosis) and Supravalvular Ring Mitral Stenosis What to Read Next on Medscape ... Supravalvular Ring Mitral Stenosis Guidelines. Updated: Dec 15, 2020 * Author: Michael D Pettersen, MD; Chief Editor: Howard S ... Mitral stenosis due to fibrous tissue overgrowth after mitral valve repair. J Cardiovasc Surg (Torino). 2003 Feb. 44(1):59-60. ...
A coronary artery stent is a small, self-expanding, metal mesh tube. It is placed inside a coronary artery after balloon ... Renal artery stenosis. *Abdominal aortic aneurysm (aortic aneurysm repair - endovascular). *Carotid artery disease (carotid ... Coronary heart disease (CHD) (angioplasty and stent placement - heart). *Peripheral artery disease (angioplasty and stent ... Interventional and surgical treatment of coronary artery disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ...
FFR is used to assess the incidence of coronary artery stenosis before selecting a treatment. This measurement is taken in the ... OPSENS - FIRST USE OF dPR FOR THE DIAGNOSIS OF CORONARY STENOSIS WITH THE HEART AT REST ... "Second generation fiber optic technology enables accuracy which is becoming even more critical when pressure over coronary ... offers an advanced optical-based pressure guidewire that aims at improving the clinical outcome of patients with coronary ...
... stenosis in group 2 patients. Conclusions - Both the presence and severity of a physiologically significant coronary stenosis ... stenosis in group 2 patients. Conclusions - Both the presence and severity of a physiologically significant coronary stenosis ... stenosis in group 2 patients. Conclusions - Both the presence and severity of a physiologically significant coronary stenosis ... stenosis in group 2 patients. Conclusions - Both the presence and severity of a physiologically significant coronary stenosis ...
... peripheral pulmonary stenosis; BOM, bilateral otitis media; URTI, upper respiratory tract infection; PD, pulmonary dysplasia; ... coronary heart disease; COPD, chronic obstructive pulmonary disease; PE, pulmonary edema; MI, myocardial infarction; NPS, ... peripheral pulmonary stenosis; BOM, bilateral otitis media; URTI, upper respiratory tract infection; PD, pulmonary dysplasia; ... TS, throat swab; CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; PE, pulmonary edema; MI, myocardial ...
Keywords: Adiponectin, coronary artery disease, stenosis. How to cite this article:. Tyagi N, Kaur C. Role of serum adiponectin ... stenosis in lumen diameter in any major epicardial coronary arteries including the left main coronary artery, left anterior ... Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease. Nitin Tyagi, ... There were decreasing levels of Ad from 4.51 to 0.13 μg/mL, with increasing stenosis of coronary arteries from 60% to 100% [ ...
Dive into the research topics of The Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & ... The Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & ... The Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & ... title = "The Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting ...
... * HOME ... 2019 힐링하트 심포지엄 - Sex difference of coronary stenosis and physiology 2020.02.03. ... 2019 힐링하트 심포지엄 - Sex Differences in Plaque Characteristics in Patients with Coronary Artery Disease 2020.02.03. ...
The first image shows the heart, indicating the location of a blockage within the left anterior descending (LAD) coronary ... This set of medical illustrations depicts coronary artery stenosis with angioplasty. The drawings across the top depict the ... This set of medical illustrations depicts coronary artery stenosis with angioplasty. The drawings across the top depict the ... Blocked Coronary Artery with Balloon Angioplasty and Stent Repair - anim017. Medical Animation. Add to my lightbox. Find More ...
Simultaneous assessment of coronary stenosis relevance with automated computed tomography angiography and intravascular ... Optimal intravascular ultrasound criteria for defining the functional significance of intermediate coronary stenosis: an ... Comprehensive assessment of coronary computed tomography angiography by using Leaman and Leiden score in overweight and obese ... Published: 2022; ; ; ; Citation: Coronary Artery Disease. 31(1):25-30, 2022 01 01.; .Institution: MedStar Heart & Vascular ...
Patient Problems Intimal Dissection (1333); Death (1802); Stenosis (2263) Event Date 11/26/2019. ... It was also reported that a (b)(6) patient with a medical history of hypertension, diabetes and coronary artery disease had a ... MAUDE Adverse Event Report: MEDTRONIC MEXICO RESOLUTE INTEGRITY RX STENT, CORONARY, DRUG-ELUTING. *. ... Lesions treated included the left main, left circumflex, left anterior artery descending and right coronary artery. Adverse ...
Strategies for Optimizing Procedural Outcomes in Patients with Severe Aortic Stenosis and Anomalous Coronary Anatomy ... Strategies for Optimizing Procedural Outcomes in Patients with Severe Aortic Stenosis and Anomalous Coronary Anatomy. David M. ... CONCLUSIONS: A tailored approach towards management of patients with severe aortic stenosis and anomalous coronary anatomy ... established therapeutic option in patients with severe aortic stenosis (AS). Anomalous coronary artery anatomy is increasingly ...
Keywords: coronary disease, stenosis, atherosclerosis, hepatitis C. Citation: Shoeib O; Ashmawy M; Badr S; El Amroosy M. ... Acute coronary syndrome and chronic infection in the Cork coronary care case-control study. Heart. 2005;91:19-22. PMID:15604325 ... Coronary angiographic findings are not different between HCV-positive and negative patients with more left descending coronary ... stenosis of one of the proximal coronary arteries). These were matched for age, sex and major risk factors (diabetes mellitus, ...
Overreporting of Deaths From Coronary Heart Disease in New York City Hospitals, 2003 - ... Occlusion and stenosis of precerebral arteries. 433. I65. Occlusion and stenosis of precerebral arteries. ... We computed a comparability ratio (coronary heart disease deaths recorded on death certificates divided by validated coronary ... Coronary heart disease (CHD) is the leading cause of death for adults in the United States, and stroke ranks third (1). In New ...
Coronary angiography showed stenosis at the ostium of left main trunk. Ascending aorta to bilateral external iliac artery ... Coronary angiography showed stenosis at the ostium of left main trunk. Ascending aorta to bilateral external iliac artery ... Coronary angiography showed stenosis at the ostium of left main trunk. Ascending aorta to bilateral external iliac artery ... Coronary angiography showed stenosis at the ostium of left main trunk. Ascending aorta to bilateral external iliac artery ...
A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream ... A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream ...
Coronary angiography showed a 95% stenosis at the trifurcation of the left main coronary artery (LMCA) involving the ostium of ... How should I treat a patient with critical stenosis of a bifurcation of the left main coronary artery with an acute angulation ... Moving image 1. Coronary angiogram showing a 95% stenosis at the trifurcation of LMCA involving the ostium of the LAD, the LCX ... A 49-year-old male with a history of prior coronary bypass graft surgery three months before came back with typical anginal ...
  • Though 64-slice CT does not overcome all of these issues, its superior resolution provides a thorough analysis of atherosclerotic disease beyond stenosis. (
  • Forty-nine had no previous history of coronary artery disease, while 10 had undergone angioplasty in the past. (
  • MSCT is more powerful for analyzing the full spectrum of atherosclerotic disease, whether it causes manifest stenosis or not, said Dr. U. Joseph Schoepf, director of CT research and development at the Medical University of South Carolina. (
  • It needs to be seen whether future generations of MSCT scanners improve stenosis grading by providing a more comprehensive insight as to the location and nature of atheroslerotic disease,' Schoepf said. (
  • To determine the factors that influence the presence of collateral vessels during coronary occlusion, we performed standardized contrast injection of the contralateral coronary artery in 58 consecutive patients, without previous myocardial infarction, undergoing percutaneous transluminal coronary angioplasty for 1-vessel disease (left anterior descending artery in 45, right coronary artery: in 10 and left circumflex artery in 3). (
  • This retrospective observational study aimed to see the angiographic association of atherosclerotic renal-artery stenosis (ARAS) with coronary artery disease in Bangladesh. (
  • Despite good sensitivity and specificity for detecting significant coronary artery disease in patients, disagreement on individual coronary arterial stenosis severity is common between MDCT and the current gold standard, conventional angiography. (
  • On the other hand, the ability to noninvasively assess coronary arterial plaque characteristics and composition in addition to lumen obstruction shows strong promise for improved risk assessment and may at last enable us to move beyond mere coronary stenosis assessment for the management of patients with coronary artery disease. (
  • Methods and results This prospective study evaluated the accuracy of the MCG, a new ECG analysis device used to diagnose ischaemic coronary artery disease (CAD). (
  • However, in previous trials that used MCG to detect the presence of relevant coronary artery disease, only a coronary angiography was the gold standard. (
  • This prospective study was designed to evaluate the accuracy of MCG in diagnosing patients with coronary artery disease with functionally significant ischaemia defined by not only coronary angiography but fractional flow reserve reference standards. (
  • 1-3 While these techniques are recognised as sensitive tests for the detection of coronary artery disease (CAD) in two or more large epicardial vessels, it is also acknowledged that they have a relatively poor specificity. (
  • Opsens offers an advanced optical-based pressure guidewire that aims at improving the clinical outcome of patients with coronary artery disease. (
  • Interventional and surgical treatment of coronary artery disease. (
  • This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). (
  • The term "coronary artery disease" (CAD) includes diseases caused due to the atheromatous changes in coronary vessels. (
  • It was also reported that a (b)(6) patient with a medical history of hypertension, diabetes and coronary artery disease had a resolute integrity des implanted. (
  • The risk factor for coronary artery disease in this patient was smoking. (
  • Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. (
  • Aims: The aim of this study was to explore the association between hepatitis C viral infection and coronary artery disease. (
  • A consecutive sample of 50 patients with abnormal angiographic findings was matched with another 50 consecutive patients with normal angiographic findings regarding age, sex, and major risk factors for coronary artery disease (diabetes mellitus, hypertension and smoking). (
  • The possible association between HCV positivity and extension of coronary artery disease may refer to the role of HCV in coronary artery disease pathology. (
  • El Amroosy M. Association between coronary artery disease and hepatitis C virus seropositivity. (
  • Many epidemiological studies found an association between several infectious etiologies and coronary artery disease (CAD) mainly due to alterations in blood lipids (3-5). (
  • Evaluation of Acute and Chronic Microvascular Coronary Disease. (
  • New York City has one of the highest reported death rates from coronary heart disease in the United States. (
  • We conducted a cross-sectional validation study by using a random sample of death certificates that recorded in-hospital deaths in New York City from January through June 2003, stratified by neighborhoods with low, medium, and high coronary heart disease death rates. (
  • We computed a comparability ratio (coronary heart disease deaths recorded on death certificates divided by validated coronary heart disease deaths) to quantify agreement between death certificate determination and clinical judgment. (
  • Coronary heart disease appears to be substantially overreported as a cause of death in New York City among in-hospital deaths. (
  • Coronary heart disease (CHD) is the leading cause of death for adults in the United States, and stroke ranks third (1). (
  • Age-adjusted deaths from coronary heart disease in New York City (NYC) versus the United States overall. (
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (
  • Patients with stable coronary artery disease and functionally significant stenoses benefit from the combination therapy of PCI plus optimal medical therapy by showing greater symptomatic improvement [ 18 ] and decreasing need for urgent revascularization. (
  • Otsuka, T., Kawada, T., Katsumata, M. & Ibuki, C. Utility of second derivative of the finger photoplethysmogram for the estimation of the risk of coronary heart disease in the general population. (
  • Coronary artery aneurysms are a rare complication of a variety of disease processes. (
  • Kawasaki disease is the most common cause of coronary artery aneurysms worldwide, particularly in children. (
  • Interestingly, clinical disease activity and serological markers do not seem to correlate well with coronary artery vasculitis or aneurysm. (
  • Systemic lupus erythematosus is an uncommon cause of coronary artery aneurysms, with Kawasaki disease being a much more common cause in children. (
  • However, children with known SLE who present with chest pain should be evaluated for coronary artery disease, including aneurysms, with echocardiograms or contrast enhanced CT. (
  • Karrar A, Sequeira W, Block J. Coronary artery disease in systemic lupus erythematosus: A review of the literature. (
  • To evaluate the acute angiographic and intermediate-term clinical results of patients with non-left main (LM) coronary artery bifurcation disease (CABD) treated with BVS, as compared with those treated with DES, using the jailed semi-inflated balloon technique (JSIBT) for side branch (SB) protection and provisional stenting. (
  • Coronary artery bifurcation disease (CABD) occurs in 15-20% of coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) [ 1 , 2 ] and remains a considerable challenge in clinical practice despite advances in modern interventional techniques and stents. (
  • DCE perfusion data from 35 subjects (14 subjects with coronary artery disease, 8 subjects with hypertrophic cardiomyopathy, and 13 healthy volunteers) were evaluated. (
  • Coronary artery disease was present in nine workers, cerebrovascular accident in one, and aortic stenosis in one. (
  • 5) Behavior Questionnaire elicited data on behavior which may be associated with coronary heart disease for examined persons ages 25-74. (
  • She had no risk factors for coronary artery disease in her medical history but it was learned that she had undergone a mitral valve replacement 2 years before because of rheumatic mitral stenosis and that no international normalized ratio (INR) analysis had been done in the last 6 months. (
  • Comparison of early and late outcomes of TAVI alone compared to TAVI plus PCI in aortic stenosis patients with and without coronary artery disease. (
  • The presence of coronary artery disease (CAD) negatively impact procedural outcomes and long-term survival after (TAVI). (
  • Treatment for aortic stenosis depends on how far the disease has progressed. (
  • If the patient is deemed to be a good candidate for surgery or TAVR, cardiac catheterization is performed to exclude significant coronary artery disease. (
  • Impact of age on clinical outcomes of antihypertensive therapy in patients with hypertension and coronary artery disease: A sub-analysis of the Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease. (
  • Optimal Blood Pressure in Patients With Coronary Artery Disease and Chronic Kidney Disease: HIJ-CREATE Substudy. (
  • Relationships between blood pressure lowering therapy and cardiovascular events in hypertensive patients with coronary artery disease and type 2 diabetes mellitus: The HIJ-CREATE sub-study. (
  • Recent randomized controlled trials have challenged the concept that increased high density lipoprotein cholesterol (HDL-C) levels are associated with coronary artery disease (CAD) risk reduction. (
  • For instance, lipid profiles are well acknowledged to be associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI) [ 1 ]. (
  • Coronary Artery Disease (CAD) is the most prevalent single cause of death and loss of Disability Adjusted Life Years (DALYs) around the world. (
  • This is also the leading cause of hypertension but the eyes, causes of conditions and death, coronary artery disease. (
  • At increased risk of developing an abdominal aortic aneurysm are men over 60 years of age, smokers, men with arterial disease (coronary or peripheral) and men whose father or brother has/had got an aneurysm. (
  • To assess myocardial perfusion (stress, rest) and late gadolinium enhancement in adult patients with known or suspected coronary artery disease (CAD). (
  • Association of Calcium Phosphorus Product and Coronary Artery Calcification in End Stage Renal Disease Patients on Dialysis. (
  • Both magnetic and manual guidewire navigation were attempted in 21 consecutive diseased coronary arteries. (
  • CAD is "a condition in which there is an inadequate supply of blood and oxygen to the myocardium," which is due to the coronary arteries occlusion and leads to mismatch of demand-supply of oxygen. (
  • A tailored approach towards management of patients with severe aortic stenosis and anomalous coronary anatomy permits optimal clinical outcomes and low-lying anomalous coronary arteries may require pre-procedural plans for PCI in deployment of TAVR prosthesis. (
  • Chronic high-grade narrowing of the coronary arteries induces subendocardial ischemia during the escalation of the myocardial oxygen demand throughout exercise or stress [ 2 ]. (
  • Using a hand-held digital caliper, three neuroradiologists independently measured D stenosis and D normal of 24 stenotic intracranial arteries. (
  • We determined how frequently two observers' measurements of percent stenosis of each of the 24 diseased arteries differed by 10% or less. (
  • Atherosclerotic stenosis of the major intracranial arteries is an important cause of ischemic stroke. (
  • The established methods for measuring extracranial carotid stenosis are not suitable for measuring percent stenosis of a major intracranial artery because the intracranial arteries have several branches, they become slightly narrower in their distal portions, and they are often tortuous (1-3) . (
  • Echocardiography is commonly used as a screening exam, with excellent visualization of the proximal coronary arteries. (
  • If you are having this test to look at your heart and the blood vessels that go to it ( coronary arteries ), you may be given a medicine called a beta-blocker to slow your heart rate during the test. (
  • A narrowing (stenosis) or blockage in the coronary arteries. (
  • Intervention group: patients with slow flow coronary arteries in angiography will be treated with standard medicine for two weeks and in case of pain continuation, will be treated with oral pentoxifylline 400 milligram three times a day for two weeks and finally pentoxifylline effect in chest pain reduction will be evaluated. (
  • Note that the arrows point out the two coronary ostia, or openings into the coronary arteries, and how syphilis caused arterial stenosis, or narrowing of these openings, a feature of late syphilis. (
  • Medial calcification is unusual in the coronary arteries and therefore any detectable coronary calcification is taken to reflect calcium within intimal atherosclerotic lesions. (
  • Necropsy studies have shown that the amount of intimal calcium in the coronary arteries is related closely to the amount of plaque. (
  • The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial - Am J Clin Nutr 2021 Oct 12 - 'In individuals with diabetes mellitus, supplementation with 10 mg vitamin K1/d may prevent the development of newly calcifying lesions within the aorta and the coronary arteries as detected using 18F-NaF PET. (
  • Cannulation was found to be selective in 12.0% and 31.7% for left and right coronary arteries, respectively. (
  • The coronary arteries are the other important arteries attached to the heart. (
  • Arbab-Zadeh, A & Hoe, J 2011, ' Quantification of coronary arterial stenoses by multidetector CT angiography in comparison with conventional angiography: Methods, caveats, and implications ', JACC: Cardiovascular Imaging , vol. 4, no. 2, pp. 191-202. (
  • Currently, there are no standard methods for measuring the severity of intracranial arterial stenosis. (
  • A canine model of the coronary circulation with three compartments was created (arterial, capillary, venous). (
  • 4. Indications: Anomalous coronary arterial stenosis when lesions clear to purulent discharge from the superior and inferior labial artery medially. (
  • Contrast-enhanced 64-slice CT can accurately detect and characterize atherosclerotic coronary lesions, according to a study published in the July issue of Journal of the American College of Cardiology. (
  • They found that 64-slice CT could identify both obstructive and nonobstructive lesions with high accuracy in all three coronaries. (
  • Guidewire navigation using MNS presented a novel, safe, and feasible approach to address coronary artery lesions. (
  • Clinical studies are needed to evaluate the potential benefit of the MNS in more complex coronary lesions and tortuous anatomy. (
  • Second generation fiber optic technology enables accuracy which is becoming even more critical when pressure over coronary lesions is measured in a resting situation. (
  • Lesions treated included the left main, left circumflex, left anterior artery descending and right coronary artery. (
  • The tools necessary for correctly identifying complex coronary lesions and plaques. (
  • The prognosis of infundibular pulmonary stenosis (IPS) mainly depends on the severity of stenosis in the absence of any additional lesions. (
  • Long-term clinical outcomes after percutaneous coronary intervention to treat long lesions in hemodialysis patients in the era of second-generation drug-eluting stents. (
  • Date of event: date of publication journal article: vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing journal: european heart journal year: 2019 ref: doi:10. (
  • Resolute integrity drug eluting stents were among a number of drug eluting stents used in a study involving autopsy cases which analysed vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans. (
  • The focal dilatation within the proximal right coronary artery contained a small amount of nonocclusive mural thrombus, as well as a thin rim of calcification (Figure 4). (
  • The last few years have seen a surge of interest in the measurement of coronary artery calcification to predict and monitor the presence of coronary atherosclerosis. (
  • Although IVUS is highly sensitive and specific for calcification, it is invasive, non-quantitative, and only visualises a limited portion of the coronary tree. (
  • Kaohsiung J Med Sci 2021 Feb 26 - 'The present cross-sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K-dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. (
  • Delicate valves can suffer from stenosis, becoming blocked by calcification or hardening, so that they constrict the blood flow. (
  • In patients with low cardiac output, the valvular stenosis may be severe even though the transvalvular gradient is low. (
  • Color Doppler valve analysis during transesophageal echocardiography (TEE) can be used to accurately diagnose bicuspid aortic valve in patients with severe symptomatic aortic stenosis, according to a prospective study of 51 patients. (
  • Most such CT studies focused on high-grade stenoses in coronary sections larger than 2 mm and in patients with relatively normal or slow heartbeats. (
  • Dr. Alexander Leber and a team of cardiologists and radiologists from the University of Munich in Germany enrolled 59 consecutive patients scheduled for conventional coronary angiography for chest pain. (
  • The 64-slice CT scanner provided images of diagnostic quality for the entire coronary tree in 55 of 59 patients. (
  • A total of 250 patients with coronary artery involvement, on non-emergent coronary angiogram who underwent either selective or nonselective renal angiography were enrolled in this study. (
  • 75% stenosis in group 2 patients. (
  • A 1-week duration of doubling the dose of clopidogrel (double-dose antiplatelet therapy (DDAT)) was shown to improve outcome at 1 month compared with conventional dose in acute coronary syndrome (ACS) patients undergoing PCI. (
  • Transcatheter aortic valve replacement (TAVR) is a well- established therapeutic option in patients with severe aortic stenosis (AS). (
  • 3 patients patients with anomalous RCA arising from near the left-right coronary commisure with a course cephalad to and remote from the aortic annulus and had uncomplicated deployment of the TAVR (2) and minimally invasive surgical aortic valve replacement (1) requiring no coronary interventions. (
  • Patients who will experience little benefit from coronary revascularization are also excluded. (
  • Patients with comorbid CAD and ventricular hypertrophy suffer from myocardial hypoperfusion at subcritical epicardial stenosis. (
  • 170 patients underwent MCE during dobutamine stress echocardiography prior to coronary angiography. (
  • Patients with SLE frequently have coronary artery manifestations, with atherosclerosis being much more common than aneurysms. (
  • Medical treatment in aortic stenosis essentially is reserved for patients who have complications of the disorder, such as heart failure, infective endocarditis, hypertension, or arrhythmias. (
  • The medical treatment options are limited in symptomatic patients with aortic stenosis who are not candidates for surgery. (
  • Antibiotic prophylaxis for the prevention of bacterial endocarditis is no longer recommended in patients with valvular aortic stenosis. (
  • Patients with aortic stenosis who are not candidates for surgery and present with pulmonary congestion may be treated with digoxin. (
  • Patients with severe symptomatic aortic stenosis (AS) (n = 249) that underwent TAVI were divided into two groups patients with CAD (subdivided to patients treated with TAVI alone and to patients that underwent PCI before TAVI) and patients with isolated AS. (
  • Patients with isolated valvular pulmonary stenosis may have a reactive infundibular hypertrophy that could elicit a reactive infundibular obstruction. (
  • Patients with mild-to-moderate stenosis live normal lives with no symptoms, apart from the risk of IE. (
  • Coronary cannulation failures following transcatheter aortic valve replacement (TAVR) were found to be higher in patients receiving Evolut TAVs, according to a study published in the Journal of American College of Cardiology: Cardiovascular Interventions . (
  • Patients were assessed with left and right coronary angiography before and after the procedure. (
  • Evaluation of the cut-off value for the instantaneous wave-free ratio of patients with aortic valve stenosis. (
  • Variations in the eicosapentaenoic acid-arachidonic acid ratio associated with age in acute myocardial infarction patients undergoing primary percutaneous coronary intervention. (
  • Safety and Efficacy of Low-Dose Prasugrel as Part of Triple Therapy With Aspirin and Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention - From the TWMU-AF PCI Registry. (
  • Clinical characteristics of octogenarian patients under- going percutaneous coronary intervention. (
  • Annual operator volume among patients treated using percutaneous coronary interventions with rotational atherectomy and procedural outcomes : analysis based on a large national registry. (
  • Clinical outcomes in patients undergoing complex, high-risk percutaneous coronary intervention and haemodynamic support with intra-aortic balloon versus Impella pump : real-life single-centre preliminary results. (
  • While transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic stenosis, a new study in the American Journal of Cardiology showed that there may be a high risk of in-hospital mortality for patients who undergo surgical aortic valve replacement (SAVR) after TAVR. (
  • As with all valvular diseases, exertional dyspnea is the most common presenting symptom (80% of patients with mitral stenosis). (
  • Thus, in a patient with clinical features of severe aortic stenosis but echo/Doppler findings of mild to moderate aortic stenosis, further evaluation with repeat Doppler or cardiac catheterization may be required. (
  • We defined percent stenosis of an intracranial artery as follows: percent stenosis = [(1 − (D stenosis /D normal ))] × 100, where D stenosis = the diameter of the artery at the site of the most severe stenosis and D normal = the diameter of the proximal normal artery. (
  • Stenosis was qualitatively classified as mild, moderate, or severe by 1 blinded observer and the results were compared with those of ICA, which was used as the gold standard. (
  • Such reversal and cyanosis can occur when the RV is hypoplastic, even with less severe pulmonary stenosis. (
  • In neonates with severe pulmonary stenosis, the pulmonary blood flow depends on the patency of the ductus arteriosus. (
  • interquartile range [IQR], 77-85 years) presenting with severe aortic stenosis of the native valve and scheduled to undergo TAVR were enrolled. (
  • However, medication is a palliative therapy and is not an effective treatment for severe aortic stenosis. (
  • The only effective treatment for severe aortic stenosis is to replace the diseased aortic valve. (
  • A coronary artery stent is a small, self-expanding, metal mesh tube. (
  • one patient had TAVR with prophylactic placement of an intracoronary stent and wire, experienced acute coronary occlusion following deployment of the TAVR prosthesis and was successfully treated by positioning and expansion of the stent with return of circumflex artery perfusion and hemodynamic stabilization. (
  • If stenosis or thrombosis occurs, coronary stenting can be done, though stenosis from vasculitis can be more difficult to stent than stenosis from atherosclerosis. (
  • It is placed inside a coronary artery after balloon angioplasty . (
  • This set of medical illustrations depicts coronary artery stenosis with angioplasty. (
  • We did not perform acute coronary syndrome, coronary elevation myocardial infarction, whereas angioplasty because the obstruction embolism should be kept in mind in the rest present with non-ST elevation was in the distal portion of the vessel those with prosthetic valves even in the myocardial infarction [8]. (
  • This image showed focal dilatation of the proximal right coronary artery (RCA), just distal to the origin of the artery (Figures 2 and 3) corresponding to the soft-tissue abnormality identified on the non-contrast CT scan. (
  • A few smaller areas of focal dilatation were identified within the distal right coronary artery (Figure 3). (
  • The right coronary artery is most commonly affected. (
  • We report here a case of embolic portion of the right coronary artery 5 mm (Figure 2). (
  • The presence of collateral vessels during coronary occlusion, defined as partial or complete epicardial opacification by collateral vessels of the vessel dilated, was related to clinical, angiographic and electrocardiographic parameters. (
  • By combining lesion severity with the duration of angina, collateral vessels during coronary occlusion were particularly related to a lesion severity greater than or equal to 70% and duration of angina greater than or equal to 3 months (p less than 0.001). (
  • Furthermore, the presence of collateral vessels was associated with an absence of ST-segment shift (greater than or equal to 1 mm) during 1 minute of coronary occlusion (p less than 0.001). (
  • Coronary stenosis and occlusion are important complications. (
  • However, there remains a risk of acute SB occlusion after MV stenting, especially in a true bifurcation lesion with large plaque burden, very tight stenosis at the SB ostium, diminished baseline SB blood flow, or very blunt bifurcation angulations [ 6 , 7 ]. (
  • Coronary angiography showed stenosis at the ostium of left main trunk. (
  • Coronary angiography showed a 95% stenosis at the trifurcation of the left main coronary artery (LMCA) involving the ostium of the left anterior descending artery (LAD), the left circumflex artery (LCX), and the ramus intermedius (RI). (
  • Coronary angiography showed insignificant coronary artery stenosis. (
  • The "Polar Light Sign" is a useful tool to detect discrete membranous supravalvular mitral stenosis. (
  • del Nido PJ, Baird C. Congenital mitral valve stenosis: anatomic variants and surgical reconstruction. (
  • In this paper, we report a rare case of myocardial infarction, which occurred as a result of a coronary embolism in a patient with prosthetic mitral valve thrombosis. (
  • The classic murmur of mitral stenosis and associated signs are listed in Table 23-1 . (
  • In procedures where the aortic valve replacement (AVR) is combined with a coronary artery bypass graft (CABG), the use of a rapid deployment valve can shorten the duration of cardiac ischemia and the overall intervention duration, which possibly has an influence on clinical results. (
  • A 49-year-old male with a history of prior coronary bypass graft surgery three months before came back with typical anginal chest pain on exertion. (
  • Coronary artery bypass graft surgery is also performed, often with resection of aneurysms. (
  • 2020. Intraoperative graft flow profiles in coronary artery bypass surgery: A meta-analysis. . (
  • Ad levels showed a significant decrease with increasing coronary artery stenosis. (
  • [ 20 ] Two-dimensional and Doppler echocardiography is the imaging modality of choice to diagnose and determine the severity of aortic stenosis. (
  • [ 5 ] In general, cardiac catheterization is not necessary to determine the severity of aortic stenosis. (
  • Although the presence of aortic stenosis is readily diagnosed with 2D echocardiography, the severity of aortic stenosis cannot be judged based on the 2D echocardiographic images alone. (
  • Doppler echocardiography is an excellent tool for assessing the severity of aortic stenosis. (
  • The echocardiographic criteria for assessment of aortic stenosis severity are outlined below, in Table 2. (
  • The major limitation of Doppler echocardiography in assessing the severity of aortic stenosis is underestimation of the gradient if the sound beam is not parallel to the aortic stenosis velocity jet. (
  • Conclusions - Both the presence and severity of a physiologically significant coronary stenosis can be detected at rest by measuring the increase in aBV on myocardial contrast echocardiography that occurs distally to the stenosis without recourse to any form of stress. (
  • Both these markers fluctuate with the increasing levels of coronary artery stenosis and thus their monitoring may be helpful in monitoring the increasing severity of the CAD. (
  • The severity of stenosis can progress with age. (
  • The Authors' Reply: Which Functional Imaging Should We Refer to When Encountering an Anatomically Intermediate Coronary Stenosis? (
  • Rangasetty, UC & Lui, CY 2008, ' Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses ', Journal of the American College of Cardiology , vol. 51, no. 11, pp. 1123. (
  • Lui, Charles Y. / Fractional Flow Reserve-Guided Intervention of Angiographically Nonsignificant Coronary Stenoses . (
  • Crea, F , De Caterina, A & Leone, AM 2013, ' Superiority of fractional flow reserve versus intravascular ultrasound for intermediate coronary stenoses ', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY , vol. 62, pagg. (
  • Area stenosis associated with non-invasive fractional flow reserve obtained from coronary CT images. (
  • 8 g/dL), a small aortic root, or sequential stenoses in parallel (coexistent LV outflow tract [LVOT] and valvular obstruction). (
  • The overall correlation between CT, conventional angio, and intravascular ultrasound for the assessment of stenosis degree, mean plaque areas, and percentage of vessel obstruction was statistically significant. (
  • Coronary artery obstruction during and after TAVR procedure can occur in 0.5-1.0% of individuals. (
  • One cause of obstruction can be compression of an anomalous coronary artery during deployment of the TAVR prosthesis. (
  • First described by Elliotson, infundibular pulmonary stenosis (IPS) refers to obstruction of outflow from the right ventricle (RV) within the body of the RV, as opposed to obstruction at the pulmonary valve, pulmonary artery (PA), or its branches. (
  • They are more prone to develop ischemic complications, mainly non-ST-elevation myocardial infarction (NSTEMI), and arrhythmias than their peers with isolated CAD regarding the same degree of coronary stenosis. (
  • Myocardial infarction due to stenosis of the left coronary artery. (
  • Diagnostic dilemma of perioperative myocardial infarction after coronary artery bypass grafting: A review. (
  • IMSEAR at SEARO: Isolated left main coronary ostial stenosis in a young female. (
  • Tewari S, Roy S, Kapoor A, Sinha N. Isolated left main coronary ostial stenosis in a young female. (
  • How should I treat a patient with critical stenosis of a bifurcation of the left main coronary artery with an acute angulation between the left main artery and the left circumflex artery? (
  • The investigators compared 64-slice CT with catheter angiography and intravascular ultrasound to identify and quantify coronary plaque, another departure from previous trials comparing CT exclusively against catheter angiography. (
  • CT and intravascular ultrasound identified 46 and 55 coronary plaques, with a sensitivity of 84% and 100%, respectively. (
  • In addition to detection of stenoses, 64-slice CT enables noninvasive analysis of the vessel wall, something that neither catheter angiography nor intravascular ultrasound can do. (
  • An In-Depth Insight of Intravascular Ultrasound for Coronary Stenting. (
  • The study endpoint was defined as an intraluminal wire position distal to the stenosis. (
  • Most studies of CAD revascularization have been based on and reported according to angiographic criteria which do not consider the relation between the resulting effective flow distal to the stenosis and the demand of a hypertrophied myocardial tissue. (
  • The standard values provided by both methods, and so the revascularization decision, do not consider the relation between the resulting effective flow distal to the stenosis and the demand of a comorbid hypertrophied myocardial tissue. (
  • Prinzmetal's angina or coronary artery vasospasm). (
  • A variant form of angina pectoris caused by coronary artery vasospasm, usually occurring spontaneously and frequently associated with ST segment elevation. (
  • Angina is a specific type of pain in the chest caused by inadequate blood flow through the blood vessels (coronary vessels) of the heart muscle (myocardium). (
  • To assess the safety and effectiveness of performing percutaneous coronary intervention (PCI) before transcatheter aortic valve implantation (TAVI). (
  • Coronary angiogram showing a 95% stenosis at the trifurcation of LMCA involving the ostium of the LAD, the LCX, and the RI branch with angulation between the LMCA and the LCX of nearly 90 degrees. (
  • TVAR was considered selective when the catheter was completely engaged, semiselective when the catheter was in front of the coronary ostium, and unsuccessful when it was impossible to obtain selective or semiselective engagement. (
  • Hence, the study was conducted to evaluate the Ad levels and its correlation with the angiographic stenosis of CAD. (
  • In the more common type, stenosis of the proximal portion of the infundibulum is due to a fibrous or muscle band at the junction of the main cavity of the right ventricle (RV) and the infundibulum. (
  • Multidetector computed tomography (MDCT) is a rapidly evolving technology for performing noninvasive coronary angiography. (
  • Discrepant stenosis assessment by MDCT and conventional angiography receives remarkable attention, whereas its significance for patient outcome is less certain. (
  • Anomalous coronary artery anatomy is increasingly being recognized prior to intervention as routine 3-dimensional reconstructed computed tomographic imaging is used as part of pre-procedural planning (MDCT). (
  • Role of MDCT for the Diagnosis of Coronary Anomalies and Fistulae. (
  • Multidetector computed tomography (MDCT) has been demonstrated as a feasible alternative to invasive coronary angiography (ICA). (
  • However, contradictory results have been reported regarding the effect of coronary artery calcium score (CS) on the diagnostic accuracy of MDCT. (
  • A total of 484 segments with coronary stenosis ≥ mild were qualitatively evaluated and quantified with MDCT. (
  • Freitas1 coronary interventions (PCI) in octogenarians are increasingly indicated. (
  • Two-dimensional transthoracic echocardiography can confirm the clinical diagnosis of aortic stenosis and provide specific data on LV function. (
  • In addition, an antiplatelet regimen is an integral component of medical therapy after percutaneous coronary intervention (PCI). (
  • CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (
  • Outcomes of Renal Transplant Recipients after Percutaneous Coronary Intervention. (
  • Comparison of safety and effectiveness between the right and left radial artery approach in percutaneous coronary intervention. (
  • Mayo Clinic doctors trained in heart and blood vessel conditions (cardiologists) and heart and blood vessel surgery (cardiovascular surgeons) research diagnosis and treatment options for aortic valve stenosis and other heart valve diseases. (
  • In this article, IPS refers to isolated infundibular pulmonary stenosis with an intact ventricular septum. (
  • Infundibular pulmonary stenosis (IPS) has two forms. (
  • pulmonary stenosis (or hypoplastic right heart syndrome). (
  • Treatment of valvular aortic stenosis is interventional. (
  • endocarditis, atrial and ventricular mu- ing treatment of coronary embolism. (
  • Background - We hypothesized that autoregulatory changes in arteriolar blood volume (aBV) that develop distal to a stenosis can be measured with myocardial contrast echocardiography, allowing coronary stenosis detection at rest without recourse to stress. (
  • Objectives The aim of this study was to evaluate the accuracy of the Multifunction CardioGram (MCG) in detecting the presence of functionally significant coronary ischaemia. (
  • The MCG might have the strength to identify functionally significant coronary ischaemia needing an optimal revascularisation. (
  • Commentary: Functional coronary artery stenosis-How can we functionally apply this to the operating room? (
  • In addition the reduction in aortic compliance may result in a decrease in diastolic coronary perfusion, as this is dependent on the recoil of the aorta which has been stretched during systole. (
  • Although coronary embolism was performed because her chest pain tral prosthetic valve. (
  • The chest pain of the patient was assessed to be typical of acute coronary syndrome. (