Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
The veins and arteries of the HEART.
The circulation of blood through the CORONARY VESSELS of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Narrowing or constriction of a coronary artery.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Use of a balloon CATHETER to block the flow of blood through an artery or vein.
Elements of limited time intervals, contributing to particular results or situations.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Spasm of the large- or medium-sized coronary arteries.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The act of constricting.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Chronic absence from work or other duty.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Contractile activity of the MYOCARDIUM.
Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)
Sense of awareness of self and of the environment.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Drugs used to cause dilation of the blood vessels.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Application of a ligature to tie a vessel or strangulate a part.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Motion pictures of the passage of contrast medium through blood vessels.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
10-carbon saturated monocarboxylic acids.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Treatment process involving the injection of fluid into an organ or tissue.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Organic compounds containing both the hydroxyl and carboxyl radicals.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The return of a sign, symptom, or disease after a remission.
The relationship of all the components of the masticatory system in normal function. It has special reference to the position and contact of the maxillary and mandibular teeth for the highest efficiency during the excursive movements of the jaw that are essential for mastication. (From Jablonski, Dictionary of Dentistry, 1992, p556, p472)
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
The flow of BLOOD through or around an organ or region of the body.
The degree to which BLOOD VESSELS are not blocked or obstructed.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Disease having a short and relatively severe course.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Radionuclide ventriculography where a bolus of radionuclide is injected and data are recorded from one pass through the heart ventricle. Left and right ventricular function can be analyzed independently during this technique. First-pass ventriculography is preferred over GATED BLOOD-POOL IMAGING for assessing right ventricular function.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Obstruction of flow in biological or prosthetic vascular grafts.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Substances used to allow enhanced visualization of tissues.
A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
The innermost layer of the heart, comprised of endothelial cells.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
Pathologic deposition of calcium salts in tissues.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The vessels carrying blood away from the heart.
Sulfhydryl acylated derivative of GLYCINE.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Diet modification and physical exercise to improve the ability of animals to perform physical activities.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The condition of an anatomical structure's being constricted beyond normal dimensions.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Radiography of blood vessels after injection of a contrast medium.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The treatment of patients without the use of allogeneic BLOOD TRANSFUSIONS or blood products.
Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Contact between opposing teeth during a person's habitual bite.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Methods used to temporarily or permanently block the flow of BODY FLUIDS through various ducts and tubules throughout the body, including BLOOD VESSELS and LYMPHATIC VESSELS such as by THERAPEUTIC EMBOLIZATION or LIGATION.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
The arterial blood vessels supplying the CEREBRUM.
An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Pressure, burning, or numbness in the chest.
Radiography of the vascular system of the brain after injection of a contrast medium.
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.
Injections made into a vein for therapeutic or experimental purposes.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Formation and development of a thrombus or blood clot in the blood vessel.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The relationship between the dose of an administered drug and the response of the organism to the drug.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.
Pathological conditions of intracranial ARTERIES supplying the CEREBRUM. These diseases often are due to abnormalities or pathological processes in the ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; and POSTERIOR CEREBRAL ARTERY.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
The main artery of the thigh, a continuation of the external iliac artery.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
The vein which drains the foot and leg.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Lesions formed within the walls of ARTERIES.
Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Reciprocal changes in 12-lead electrocardiography can predict left main coronary artery lesion in patients with acute myocardial infarction. (1/321)

Acute left main coronary artery (LMCA) occlusion may result in acute myocardial infarction (AMI) or sudden death. ST elevation in the aVR and V1 leads is reported to be valuable in recognizing LMCA occlusion. Early recognition of electrocardiogram (ECG) changes, such as reciprocal ST depression in other leads, is helpful in averting this disaster. This study aimed to determine the reciprocal ST segment depression of 12-lead ECGs associated with acute LMCA occlusion. From January 2000 to December 2004, 61 patients who underwent emergency percutaneous coronary intervention in 3 hospitals due to AMI associated with LMCA (n = 18) and a left anterior descending coronary artery (LADCA) (n = 43) proximal lesion were selected. Reciprocal ST segment depression occurred in leads aVF, V(2), V(3), V(4), V(5), and V(6) with significantly higher incidence in the LMCA group than in the LADCA group. Stepwise linear multivariate discriminant analysis indicated that ST segment depression in leads aVF, V(2), and V(4) could distinguish the LMCA group from the LADCA group. We concluded that reciprocal ST segment depression in leads V(2), V(4), and aVF of a 12-lead ECG is an important predictor of acute LMCA occlusion.  (+info)

Embolised stent into the circumflex coronary artery during percutaneous coronary intervention. (2/321)

Dislodgement and embolisation of the new generation of coronary stents before deployment are rare. If it is impossible to withdraw the embolised stent from the coronary artery, the stent may be crushed into the side wall of the coronary artery with a balloon over a wire passed alongside the embolised stent.  (+info)

Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both? (3/321)

AIMS: Despite advancements over the past years, normal reperfusion at the myocardial level is not achieved in approximately every other patient with ST-elevation myocardial infarction. In the current work, we aimed at reviewing the role of the coronary microcirculation in the development and outcome of this acute coronary syndrome entity. METHODS AND RESULTS: A PubMed/Medline search was performed with the key words acute coronary syndrome, acute myocardial infarction, coronary artery disease, endothelial dysfunction, microcirculation, and reperfusion. The synthesis of the information points to myocardial microcirculatory dysfunction as a consequence of a primary epicardial event, based on the vulnerable plaque concept. As an alternative theory, microcirculatory dysfunction may contribute to the clinical course of the acute coronary event, based on the vulnerable patient concept. The pros and cons of these two viewpoints are to be discussed and their influence on patient management is to be considered. CONCLUSION: Microcirculatory dysfunction in ST-elevation myocardial infarction can be cause, consequence or both according to non-traditional and traditional concepts.  (+info)

Troponin-I concentration 72 h after myocardial infarction correlates with infarct size and presence of microvascular obstruction. (4/321)

OBJECTIVES: The aim of this study was to use late gadolinium hyper-enhancement cardiac magnetic resonance (LGE-CMR) imaging to determine if a 72-h troponin-I measurement would provide a more accurate estimation of infarct size and microvascular obstruction (MVO) than serial creatine kinase (CK) or early troponin-I values. METHODS: LGE-CMR was performed 3.7+/-1.4 days after medical treatment for acute ST elevation or non-ST elevation myocardial infarction. Infarct size and MVO were measured and correlated with serum troponin-I concentrations, which were sampled 12 h and 72 h after admission, in addition to serial CK levels. RESULTS: Ninety-three patients, of whom 71 had received thrombolysis for ST elevation myocardial infarction, completed the CMR study. Peak CK, 12-h troponin-I, and 72-h troponin-I were related to infarct size by LGE-CMR (r = 0.75, p<0.0001; r = 0.56, p = 0.0003; r = 0.62, p<0.0001 respectively). Serum biomarkers demonstrated higher values in the group with MVO compared with those without MVO (Peak CK 3085+/-1531 vs 1471+/-1135, p<0.001; 12-h troponin-I 58.3+/-46.9 vs 33.4+/-40.0, p = 0.13; 72-h troponin-I 11.5+/-9.9 vs 5.5+/-4.6, p<0.005). The correlation between the extent of MVO and 12-h troponin-I was not significant (r = 0.16), in contrast to the other serum biomarkers (peak CK r = 0.44, p<0.0001; 72-h troponin-I r = 0.46, p = 0.0002). CONCLUSION: A single measurement of 72-h troponin-I is similar to serial CK measurements in the estimation of both myocardial infarct size and extent of MVO, and is superior to 12-h troponin-I measurements.  (+info)

Type A aortic dissection with partial ostial occlusion of left main coronary artery. (5/321)

A 48-year-old hypertensive male presented with acute retrosternal pain and aortic regurgitation. The electrocardiogram showed ST-segment depression with T-wave inversion in anterolateral leads. Transesophageal echocardiography in long axis view of aorta revealed a spiral intimal flap in ascending aorta extending to the arch, diagnostic of Type A aortic dissection. The short axis view of the aorta showed partial obstruction of the left main coronary artery (LMCA) by the intimal flap with turbulent flow at its ostium. An emergency repair of aortic dissection with reconstruction of aortic wall was done. Postoperative period and ECG were normal. At 12-months of follow up, patient was doing well.  (+info)

Detection and characterization of coronary bifurcation lesions with 64-slice computed tomography coronary angiography. (6/321)

AIMS: To compare the performance of 64-slice computed tomography coronary angiography (CTCA) and invasive coronary angiography (ICA) in the detection and classification (according to the Medina system) of bifurcation lesions (BLs). METHODS AND RESULTS: We studied 323 consecutive patients undergoing 64-slice CTCA prior to ICA. All coronary segments >or=2 mm in diameter were evaluated for the presence of a significant (>or=50% diameter reduction on quantitative coronary angiography) BL. Evaluation of BL by CTCA included the assessment of significant lumen obstruction in both main and side branch vessels. Forty-one out of 43 patients (46/48 lesions) with significant BL were identified by CTCA. Excluding coronary segments with non-diagnostic image quality (5%), the sensitivity, specificity, and positive and negative predictive values of CTCA for detecting significant BL were 96, 99, and 85 and 99%, respectively. In 39 of these 41 patients, CTCA assessment was concordant with the Medina lesion classification on ICA. CONCLUSION: Sixty-four-slice CTCA allows accurate assessment of complex BL.  (+info)

Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A. (7/321)

AIMS: Studies of arrhythmogenesis during ischemia have focused primarily on reentrant mechanisms manifested on the epicardial surface. The goal of this study was to use a physiologically-accurate model of acute regional ischemia phase 1A to determine the contribution of ischaemia-induced transmural electrophysiological heterogeneities to arrhythmogenesis following left anterior descending artery occlusion. METHODS AND RESULTS: A slice through a geometrical model of the rabbit ventricles was extracted and a model of regional ischaemia developed. The model included a central ischaemic zone incorporating transmural gradients of I(K(ATP)) activation and [K+]o, surrounded by ischaemic border zones (BZs), with the degree of ischaemic effects varied to represent progression of ischaemia 2-10 min post-occlusion. Premature stimulation was applied over a range of coupling intervals to induce re-entry. The presence of ischaemic BZs and a transmural gradient in I(K(ATP)) activation provided the substrate for re-entrant arrhythmias. Increased dispersion of refractoriness and conduction velocity in the BZs with time post-occlusion led to a progressive increase in arrhythmogenesis. In the absence of a transmural gradient of I(K(ATP)) activation, re-entry was rarely sustained. CONCLUSION: Knowledge of the mechanism by which specific electrophysiological heterogeneities underlie arrhythmogenesis during acute ischaemia could be useful in developing preventative treatments for patients at risk of coronary vascular disease.  (+info)

The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth. (8/321)

OBJECTIVE: We hypothesize that controversial effects of angiotensin II (Ang II) are attributable to its regulation of reactive oxygen species (ROS) and ROS-dependent signaling. METHODS AND RESULTS: Coronary collateral growth (CCG) was stimulated in normal (WKY) and syndrome X (JCR) rats by transient/repetitive ischemia (RI). Blood flow was measured in the normal (NZ) and the collateral-dependent (CZ) zone. In WKY, RI increased CZ flow (0.84 mL/min/g), but RI+subpressor Ang II increased it more (1.24 mL/min/g). This was associated with transient p38 and sustained Akt activation. A hypertensive dose of Ang II decreased CZ flow (0.69 mL/min/g), which was associated with sustained p38 and transient Akt activation. AT1R blockade by candesartan abrogated CZ flow in WKY (0.58 mL/min/g), reduced myocardial superoxide, and blocked p38 and Akt activation. RI-induced CZ flow in JCR was significantly decreased compared with WKY (0.12 mL/min/g), associated with a large increase in superoxide and lack of p38 and Akt activation. CZ flow in JCR was partially restored by candesartan (0.45 mL/min/g), accompanied by reduction in superoxide and partial restoration of p38 and Akt activation. CONCLUSIONS: Ang II/AT1R blockade, at least in part, regulates CCG via generating optimal ROS amounts and activating redox-sensitive signaling.  (+info)

Purchase Manual of Coronary Chronic Total Occlusion Interventions - 1st Edition. Print Book & E-Book. ISBN 9780124201293, 9780128004326
TY - JOUR. T1 - Retrograde coronary chronic total occlusion revascularization. T2 - Procedural and in-hospital outcomes from a multicenter registry in the united states. AU - Karmpaliotis, Dimitri. AU - Michael, Tesfaldet T.. AU - Brilakis, Emmanouil S.. AU - Papayannis, Aristotelis C.. AU - Tran, Daniel L.. AU - Kirkland, Ben L.. AU - Lembo, Nicholas. AU - Kalynych, Anna. AU - Carlson, Harold. AU - Banerjee, Subhash. AU - Lombardi, William. AU - Kandzari, David E.. PY - 2012/12/1. Y1 - 2012/12/1. N2 - Objectives: This study sought to examine the contemporary outcomes of retrograde chronic total occlusion (CTO) interventions among 3 experienced U.S. centers. Background: The retrograde approach, pioneered and developed in Japan, has revolutionized the treatment of coronary CTO, yet limited information exists on procedural efficacy, safety, and reproducibility of outcomes in other settings. Methods: Between 2006 and 2011, 462 consecutive retrograde CTO interventions were performed at 3 U.S. ...
Increased interest focusing on coronary chronic total occlusions has emerged since several studies have proven improved cardiovascular outcomes and quality of life after successful chronic total occlusion (CTO) revascularization. CTO of an epicardial coronary artery is one of the leading challenging complex lesion type when percutaneous coronary intervention (PCI) is indicated.
Looking for online definition of Mayo-Japan Investigation for Chronic Total Occlusion in the Medical Dictionary? Mayo-Japan Investigation for Chronic Total Occlusion explanation free. What is Mayo-Japan Investigation for Chronic Total Occlusion? Meaning of Mayo-Japan Investigation for Chronic Total Occlusion medical term. What does Mayo-Japan Investigation for Chronic Total Occlusion mean?
BACKGROUND: Coronary chronic total occlusions (CTO) are the most challenging lesions to treat percutaneously. Thus, consistent efforts are made to develop new approaches to treat CTO. OBJECTIVE: To explore the key points of a novel ``crowbar effect
TY - JOUR. T1 - Advances in the management of coronary chronic total occlusions. AU - Brilakis, Emmanouil S.. AU - Karmpaliotis, Dimitri. AU - Vo, Minh N.. AU - Garcia, Santiago. AU - Michalis, Lampros. AU - Alaswad, Khaldoon. AU - Doshi, Parag. AU - Lombardi, William L.. AU - Banerjee, Subhash. N1 - Funding Information: Conflict of Interest Dr. Brilakis is a consulting/speaker honoraria from St. Jude Medical, Terumo, Janssen, Sanofi, Asahi, Abbott Vascular, and Boston Scientific and received research support from Guerbet. His spouse is an employee of Medtronic. Dr. Karmpaliotis was supported by speaker bureau, Abbott Vascular, Medtronic, and Boston Scientific. Dr. Vo is a consultant from Boston Scientific. Dr. Garcia received consulting fees from Medtronic; he is a recipient of a career development award from the VA Office of Research and Development. Dr. Michalis has no conflict of interest. Dr. Alaswad received consulting fees from Terumo and Boston Scientific; he is a consultant, with no ...
TY - JOUR. T1 - Comparison of Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusion Using Everolimus- Versus Sirolimus- Versus Paclitaxel-Eluting Stents (from the Korean National Registry of Chronic Total Occlusion Intervention). AU - Lee, Min Ho. AU - Lee, Joo M.. AU - Kang, Si Hyuck. AU - Yoon, Chang Hwan. AU - Jang, Yangsoo. AU - Yu, Cheol W.. AU - Park, Hun S.. AU - Lee, Seung Hwan. AU - Hur, Seung Ho. AU - Kim, Moo H.. AU - Rha, Seung Woon. AU - Gwon, Hyeon Cheol. AU - Chae, In Ho. AU - Kim, Hyo Soo. N1 - Funding Information: This study was supported by the Bio and Medical Technology Development Program of the National Research Foundation funded by the Ministry of Education, Science, and Technology ( 2010-0020258 ), Republic of Korea and by the Basic Science Research Program through the National Research Foundation funded by the Ministry of Education, Science, and Technology ( 2012M3A9C7050140 ), Republic of Korea. Dr. Kim is also a professor of Molecular Medicine ...
Background: With the improved lifestyle of people, the incidence of coronary artery disease is gradually increasing. Approximately 15% - 20% of patients undergoing diagnostic catheterization had one or more chronically occluded coronary arteries. Method: The patients who were diagnosed with chronic total occlusion (CTO) in our hospital within one year period have been included. They were initially divided into two groups based on angiographic reports: single vessel disease (SVD) and non-single vessel disease (non-SVD) group, then into optimal medical therapy (OMT) group, percutaneous coronary intervention (PCI) group and coronary artery bypass graft (CABG) group. Finally, PCI group is further divided into PCI of CTO lesion (CTO PCI group) and PCI of non-CTO lesion (non-CTO PCI group). Results: A total of 261 patients were enrolled as CTO patients, mean age was 62.83 years, 70.1% were male patients. The incidence rate of common risk factors was hypertension (64.4%), followed by smoking (48.3%), diabetes
AbstractBackgroundThe benefits of chronic coronary total occlusion (CTO) percutaneous coronary intervention (PCI) are being questioned. The aim of this study was to assess the effects of CTO PCI on absolute myocardial perfusion, as compared with PCI of hemodynamically significant non ‐CTO lesions.MethodsConsecutive patients with a preserved left ventricular ejection fraction ( ≥50%) and a CTO...
The reverse CART technique provides the potential to modify the retrograde procedure by improving the controlled movement of the retrograde wire and improve the success rates of percutaneous coronary intervention (PCI) of chronic total occlusion (CTO). Development of interventricular hematoma is a rare complication of CTO PCI. A 63-year-old man with effort angina with a right coronary artery CTO lesion underwent PCI by retrograde approach from the LAD to a septal branch. A contrast stain was demonstrated surrounding the septal collateral channel used for the retrograde approach at the end of the procedure without symptom ...
TY - JOUR. T1 - Coronary Computed Tomography Angiography Predicts Guidewire Crossing and Success of Percutaneous Intervention for Chronic Total Occlusion. AU - Yu, Cheol Woong. AU - Lee, Hyun Jong. AU - Suh, Jon. AU - Lee, Nae Hee. AU - Park, Sang Min. AU - Park, Taek Kyu. AU - Yang, Jeong Hoon. AU - Song, Young Bin. AU - Hahn, Joo Yong. AU - Choi, Seung Hyuk. AU - Gwon, Hyeon Cheol. AU - Lee, Sang Hoon. AU - Choe, Yeon Hyeon. AU - Kim, Sung Mok. AU - Choi, Jin Ho. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Background - We developed a model that predicts difficulty of percutaneous coronary intervention for coronary chronic total occlusion (CTO) using coronary computed tomographic angiography. Methods and Results - A total of 684 CTO lesions with preprocedural computed tomographic angiography were enrolled from 4 centers. Data were randomly divided into derivation and validation datasets at 2:1 ratio. The end point was successful guidewire crossing ≤30 minutes, which was met in 50%. The KCCT (Korean ...
A 73-year-old man with unstable angina was found to have a severely calcified chronic total occlusion (CTO) of the mid left anterior descending coronary artery (LAD). Diagnostic coronary angiography confirmed the CTO to be complex, with a flush occlusion occurring in a segment associated with proximal septal and diagonal branches. Retrograde filling of the distal LAD occurred via 2 large septal perforators from the right coronary artery (RCA). Cardiac magnetic resonance imaging demonstrated preserved left ventricular systolic function with viability.. After discussion, the patient opted for percutaneous coronary intervention. Intervention was performed by 2 high-volume CTO operators with extensive experience of retrograde CTO percutaneous coronary intervention. An initial antegrade approach failed to negotiate the calcific CTO lesion (Figure 1A). A subsequent attempt was made to treat the CTO via … ...
Contributors All authors have read and approved the manuscript. All authors agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Each author has contributed significantly to the submitted work and namely: CG, AG, AS and FM started the study and did the final validation of the results; LB, CAP, AM and AB were responsible for the collection analysis and interpretation of the data. AC, MC, GFrag and LA revised the manuscript for intellectual content. GBZ and GFrat revised the manuscript for the statistical methods; the paper received an important input from MC, MM, AM and AC. CG is responsible for the overall content as guarantor. ...
By and For the Interventional Cardiovascular community. Sharing knowledge, experience and practice in cardiovascular interventional medicine. ...
Since data from the 2 landmark studies, the BENESTENT and STRESS studies, showed that coronary stenting significantly decreases restenosis as compared with conventional balloon angioplasty, this treatment modality has shown to be superior in an increasing number of indications. Percutaneous coronary intervention of chronic total occlusions (CTO), however, is still limited by high restenosis rates. Although coronary stenting using bare metal stents significantly decreases restenosis in CTO, restenosis rates still reach 32% to 55%.. In 200 patients with CTO randomized in the PRISON I study, we demonstrated a restenosis rate of 22% after bare metal stent implantation as compared with 33% after conventional balloon angioplasty. During the past few years, sirolimus (rapamycin), a cytostatic macrocyclic lactone with anti-inflammatory and antiproliferative properties, delivered from a polymer-encapsulated stent was shown to almost eliminate the risk of restenosis in selected groups of patients.. In ...
Chronic total coronary occlusions (CTO) still remain one of the most technically challenging clinical scenarios in which to perform interventions. Although the antegrad..
Purpose: Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is still one of the challenging procedures. Multislice computed tomographic coronary angiography (CTCA) allows reliable non-invasive evaluation of coronary artery by visualizing calcium deposit, vessel tortuosity, distal flow, etc. even in the occluded site. The aim of this study is to determine the morphological predictors of procedural success in PCI for CTO using CTCA, and to estimate the value of CTCA to predict procedural outcome.. Methods: Using Somatom Sensation Cardiac 64, we performed CTCA in 91 patients who have CTO prior to PCI, and 93 CTO lesions were scanned. CTO was defined as complete occlusion of a major coronary artery on catheter coronary angiography, which was deemed to be of , 3 months duration. Procedural success was defined as complete cross of the guidewire to the occluded site. Retrograde approach, in which the guidewire was advanced from the distal end of the occluded site through the ...
TY - JOUR. T1 - Endovascular crossing of Chronic Total Occlusions using an impulse. T2 - An explorative design study. AU - Sakes, Aimée. AU - van der Wiel, Marleen. AU - Dodou, Dimitra. AU - Breedveld, Paul. PY - 2017. Y1 - 2017. N2 - In this study we investigated whether exerting an impulse on a Chronic Total Occlusion (CTO) improves the success rate of CTO crossing as compared to the currently used method of statically pushing the guidewire against the CTO. A prototype (Ø2 mm) was developed that generates translational momentum using a spring-loaded indenter and converts it to an impulse during impact. Mechanical performance was evaluated by measuring the peak force and momentum for different spring compressions and strike distances in air and blood-mimicking fluid. Puncture performance, in terms of number of punctures, number of strikes to puncture, and energy transfer from the indenter to the CTO, was assessed for six tip shapes (stamp, wedge, spherical, pointed, hollow spherical, and ...
First, a 5-F catheter was inserted via a femoral vein and advanced to the right atrium to record mean right atrial pressure (PRA). This catheter also served as central venous line. Then the donor artery was visualized by a 6-F guiding catheter, and a pressure wire (PressureWire, RADI Medical Systems, Uppsala, Sweden) was advanced into artery. The pressure sensor was positioned exactly at the takeoff of the collateral, and the local pressure (PD) together with the mean aortic root pressure (PAo) were recorded during 3 min of maximum peripheral vasodilation induced by central venous infusion of adenosine (140 μg/kg/min). The pressure difference along the epicardial donor artery segment was measured as: PAo− PD. Before and during adenosine infusion, PRAwas recorded. The FFRDwas calculated as: (PD− PRA)/(PAo− PRA) (17,18). After stopping adenosine and returning to baseline pressures, the wire was advanced further distal into the donor artery in order to assess the CFRDusing the recently ...
The main finding from this large prospective, observational, multicenter registry of consecutive CTO recanalizations across all U.K. PCI centers between 2005 and 2009 is the strong association between successful CTO revascularization and improved survival over a median follow-up of 2.65 years (interquartile range: 1.59 to 3.83 years). This is important because a recent large observational study found an association between successful CTO intervention and fewer cardiovascular deaths but did not demonstrate an increase in absolute survival (9). The improvement in survival remained after multivariate analysis, suggesting that it is independent of measurable confounding factors. The survival outcome of successful revascularization did not vary between the different epicardial vessels.. Increasing age, diabetes, heart failure, smoking, and renal disease were confirmed as factors associated with increased all-cause mortality, whereas increasing age, smoking history, increasing body mass index, ...
Chronic total occlusions (CTO) are encountered in almost one-fourth of patients undergoing coronary angiography. The presence of an untreated CTO has been related to adverse clinical prognosis, both in stable angina and acute myocardial infarction, and is often associated with persistent symptomatic angina. Depending on their symptomatic and functional status as well as anatomical complexity, CTO can be treated by optimal medical therapy only or therapy combined with coronary revascularization.. The potential benefits of percutaneous coronary intervention (PCI) in CTO include symptom relief, improved left ventricular function, and potentially a survival advantage associated with success when compared with failed revascularization. Of note, marked advances in endovascular techniques and device technology have resulted in substantial improvements of procedural success rates of PCI in CTO.. In spite of these advances, the vast majority of patients with CTO are still being managed medically or ...
OBJECTIVE: Chronic total occlusion (CTO) of coronary arteries represents a challenge for percutaneous treatment. Although ameroid constrictors have been used to create CTOs from extrinsic compression of coronary arteries, this model is not suitable f
The prevalence of heart failure depends on the definition used, but it is estimated that it affects approximately 1% to 2% of the general population and approximately 10% of those ,70 years of age, with coronary artery disease being the most common etiology (1). Chronic total occlusions (CTO) are found in ∼20% of patients without prior surgical revascularization undergoing nonurgent coronary angiography (2). This incidence is even higher in selected subgroups of patients such as those presenting with an acute coronary syndrome (47%), prior surgical bypass (coronary artery bypass grafting [CABG]) (89%), or in implantable cardioverter defibrillator recipients due to ischemic cardiomyopathy (∼50%) (3-6). It has largely been shown that the presence of a CTO confers a negative impact on long-term prognosis in several clinical scenarios. In the setting of acute coronary syndrome (with or without cardiogenic shock), a coexisting CTO is associated with worse early and late mortality (3,7,8). In ...
Percutaneous revascularisation of chronic total occlusions (CTO) is limited by failure of guidewire crossing. Neovascularisation within the proximal CTO segment may be important for guidewire crossing and dramatically declines in CTO beyond six weeks
OBJECTIVE: This study aimed to examine predictors and clinical outcomes of periprocedural myocardial infarction (PMI) after chronic total occlusion (CTO) intervention. BACKGROUND: There are limited data on the clinical implications of PMI after CTO intervention in the new-generation drug-eluting stent (DES) era. METHODS: We enrolled 337 patients who underwent CTO intervention and met the study criteria. We evaluated the incidence and predictors of PMI, defined as an increase in creatine kinase-MB ≥3× the upper limit of normal (ULN) after intervention and compared the occurrence rates of major adverse cardiac and cerebrovascular events (MACCE, defined as the composite of cardiac death, myocardial infarction, stent thrombosis, target-vessel revascularization, or cerebrovascular accidents) between the PMI and non-PMI groups ...
The study is the largest in the United States to examine the safety and effectiveness of a so-called retrograde approach to angioplasty and stenting of chronic total occlusions (CTOs). Using this innovative technique, interventional cardiologists at three medical centers were successful in tunneling through the obstruction, opening the blocked artery and restoring blood flow to the heart in about 80 percent of patients, many of whom had no alternative treatment options.. Patients with chronic total occlusions experience chest pain, shortness of breath and other disabling symptoms, said Tesfaldet T. Michael, MD, a cardiology research fellow at the University of Texas Southwestern Medical Center inDallas. When medical therapy fails, percutaneous coronary intervention (PCI) may be the last resort. It really helps patients to have a better quality of life.. Up to one-third of patients who undergo diagnostic angiography have cholesterol plaque that completely blocks a coronary artery. If they ...
Several large studies (2,5) have reported on the clinical impact of successful percutaneous CTO revascularization. In particular, studies have shown that successful PCI of a CTO lesion reduces the incidence of MI, cardiac death, and bypass surgery, resulting in enhanced 1-year survival. From this point of view, the influence of the immediate result of a CTO procedure on long-term outcomes is an important factor. In recent contemporary series, procedural success rates have ranged from 55% to 80%, with the variability reflecting differences in operator technique and experience, availability of advanced guidewires, CTO definitions, and case selection (2,15). Recent procedural outcomes after PCI for CTO lesions have increased significantly due to improved device technology, as well as technique and experience, such that successful recanalization of true CTOs may now be achieved in approximately 80% of attempted lesions (2,5,16). We reported that technical success was achieved in 207 (92.4%) of 224 ...
Expertise, Disease and Conditions: Acute Myocardial Infarction (AMI), Cardiac Catheterization, Cardiovascular Diseases, Cardiovascular Interventions, Carotid Artery Disease, Carotid Artery Stenosis, Carotid Artery Stenting, Chronic Total Coronary Occlusion, Chronic Total Occlusions, Circulatory Support Devices, Coronary Angiography, Coronary Artery Disease, Coronary Artery Stenting, Coronary Care Unit, Emboli-Protection Devices, Endovascular Therapies, Fractional Flow Reserve, Heart Disease, Hypertension, Interventional Cardiology, Intravascular Ultrasound (IVUS), Invasive Cardiology, Laser Atherectomy, Lower Extremity Revascularization, Pericardiocentesis, Peripheral Angiography, Peripheral Arterial Disease (PAD), Peripheral Vascular Disease, Renal Artery Disease, Restenosis, Rotational Atherectomy, Trans-Radial Intervention, Valvular Heart Disease, Valvuloplasty for Valvular ...
PCI was successful in a total of 582 (69.6%) procedures. Stents were implanted in 97.0% of successful procedures and drug-eluting stents were used in 73%. Procedural complications, including coronary dissection, were more frequent in unsuccessful cases (20.5% vs. 4.9%; p < 0.0001), but there was no difference in in-hospital major adverse cardiac events (3% vs. 2.1%; p = not significant). All-cause mortality at 5 years was significantly higher in patients with failed recanalization (17.2% vs. 4.5%; p < 0.0001). The need for coronary artery bypass grafting was significantly lower following successful CTO PCI (3.1% vs. 22.1%; p < 0.0001). After adjusting for the differences in baseline variables, successful PCI of a CTO was independently associated with a lower mortality (hazard ratio, 0.32; 95% confidence interval, 0.18-0.58).. ...
Expertise, Disease and Conditions: Acute Coronary Care, Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Adult Congenital Heart Disease, Angina, Angioplasty, Atherosclerosis, Atherosclerosis Imaging, Cardiac Catheterization, Cardiac Disease, Cardiac Imaging, Cardiology, Cardiomyopathy, Cardiovascular Computed Tomography, Cardiovascular Disease in Women, Cardiovascular Disease with Chronic Renal Disease, Cardiovascular Diseases, Cardiovascular Interventions, Cardiovascular Medicine, Cardioversion, Chest Pain, Chronic Total Coronary Occlusion, Chronic Total Occlusions, Clinical Cardiology, Congenital Heart Disease, Congestive Heart Failure (CHF), Coronary Angiography, Coronary Artery Disease, Coronary Artery Stenting, Coronary CT Angiography, Coronary Endothelial Function, CT Angiography, General Cardiology, Heart Attack, Heart Conditions, Heart Disease, Heart Disease Prevention and Treatment in Women, Hypertrophic Cardiomyopathy, Interventional Cardiology, Intravascular ...
The data were statistically analyzed by SPSS Statistics version 24 (IBM, Armonk, NY, USA) and Medcalc 11.1 statistical program (Medcalc, Gent, Belgium). Continuous values are expressed as means±standard deviation. Categorical data are presented as frequencies and percentages. Normality was evaluated by the Shapiro-Wilk test. Normally distributed values were compared by an unpaired t test, and non‐normally distributed values were compared by the Kruskal-Wallis rank test or the Mann-Whitney U test. Categorical data were compared by the χ2 test or Fisher exact test. We used logistic regression models to identify predictors of technical failure in overall CTO‐PCI by univariate and multivariate analysis with a forward stepwise algorithm and forced inclusion models. However, logistic regression analyses are sometimes difficult to apply directly to patients in daily clinical practice because of variation in the number, type, and severity of their comorbidities. Therefore, recursive partitioning ...
The procedural success rates of percutaneous intervention for chronic total coronary occlusions (CTOs) over the past decade have been increasing, driven by the development of specialized guidewires and microcatheters and the introduction of new technical strategies, including antegrade subintimal re-entry and the retrograde transcollateral approach. An ongoing challenge is to select the most promising strategy early to reduce total procedure time, to reduce radiation and contrast exposure, and to further improve complication-free procedural success rates. In this regard, procedural planning is typically based on the angiographic assessment of the occluded lesion, including features of the proximal cap, the extent of calcification, and the apparent length of the lesion (1). Pre-procedural coronary computed tomographic angiography (CTA) with modern high-resolution scanners may provide incremental information about the features of the coronary occlusion, which might enhance procedural planning and ...
SAN DIEGO, CA-One-fifth of patients undergoing PCI for a chronic total occlusion (CTO) have chronic kidney disease (CKD), according to new registry data. However, while the incidence of contrast-induced acute kidney injury (CI-AKI) was almost doubled for patients with CKD, this did not lead to higher rates of new dialysis or target lesion failure over follow-up.. Lorenzo Azzalini, MD, PhD (San Raffaele Scientific Institute, Milan, Italy), who presented the results Friday at TCT 2018, told TCTMD that these results should encourage dedicated CTO operators in that they should not be scared to perform this procedure in patients with CKD. Rather, good results can be achieved by paying attention to identifying high-risk patients, using intravenous hydration, avoiding ad hoc procedures, setting a maximum contrast level, and defaulting to a retrograde approach, he stressed.. The study, also appearing in the October 2018 issue of the Canadian Journal of Cardiology, included 1,092 patients-19.6% with ...
Abstract To define the prevalence of total coronary occlusion in the hours after transmural myocardial infarction, we used coronary arteriography to study the degree of coronary obstruction in 322 patients admitted within 24 hours of infarction. Total coronary occlusion was observed in 110 of 126 patients (87 per cent) who were evaluated within four hours of the onset of symptoms; this proportion decreased significantly, to 37 of 57 (65 per cent), when patients were studied 12 to 24 hours after the onset of symptoms. Among 59 patients with angiographic features of coronary thrombosis, the thrombus was retrieved by Fogarty catheter in 52 (88 per cent) but was absent in seven (12 per cent false positive). Among an additional 20 patients without angiographic features of thrombosis, a thrombus was discovered in five (25 per cent false negative). Thus, total coronary occlusion is frequent during the early hours of transmural infarction and decreases in frequency during the initial 24 hours, ...
1 Kavteladze Z. Retrograde recanalization of tibial CTOs. Presented at: TCT 2010; September 21-25, 2010; Washington, DC.. 2 Montero-Baker M, Schmidt A, Bräunlich S, et al. Retrograde approach for complex popliteal and tibioperoneal occlusions. J Endovasc Ther. 2008;15(5):594-604.. 3 Belch JJ, Topol EJ, Agnelli G, et al. Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med. 2003;163(8):884-892.. 4 Norgren L, Hiatt WR, Dormandy JA, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). Eur J Vasc Endovasc Surg. 2007;33(suppl 1):S1-S75.. 5 Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes. In: Harris MI, Cowie CC, Stern MP, et al., eds. Diabetes in America. 2nd ed. Washington, DC: National Institute of Diabetes and Digestive and Kidney Diseases, 1995:409-428.. ABOUT COOK MEDICAL. A global pioneer in medical breakthroughs, Cook Medical is committed to creating effective ...
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Besides severity of coronary obstruction [37, 38], numerous factors that could possibly attenuate the development and biological function of coronary collaterals have been reported such as old age [39], traditional risk factors for coronary artery disease [40-44], hyperlipoprotein (a) [45], hyperuricemia [46] and elevated serum levels of CRP [47], TNF-a [48], N-terminal pro-brain natriuretic peptide [38] and mimecan [49], and high neutrophil/lymphocyte ratio [50]. In contrast, higher plasma levels of MCP-1 [51] or apelin [52] were associated with better coronary collateral development. The presence and extent of spontaneously visible coronary collaterals was also affected by plasma chemokine concentrations, as higher collateralization was associated with increased concentration of the angiogenic ligand and decreased concentrations of angiostatic ligands, and interferon-c [53]. It is known that diabetes mellitus aggressively induces atherosclerosis and may be more susceptible to myocardial ...
Περιγραφή: A 60 year gentleman underwent PCI of a CTO of the RCA. We used a 7F AL1 guide catheter through the right femoral artery, and a 6F JL3.5 through the right radial artery for contralateral injection. While trying to cross the lesion with a hydrophilic wire loaded to a microcatheter, contrast extravasation was noticed (type II perforation). The patient was hemodynamically stable without signs of overt extravasation. We thus tried to conservatively treat the perforation by prolonged infusion of a 3.0mm balloon (~5 min). During the inflation, the patient was asymptomatic and we tried again to cross the occlusion using a hydrophilic wire through the balloon catheter. Crossing was successful, while contrast extravasation was no longer present. We subsequently treated the lesion with two 3.0x30mm and 2.5x30mm DES, following predilation with 2.0mm and NC 3.0mm balloons ...
Prognostic impact of recanalizing chronic total occlusion in non-infarct related arteries on long-term clinical outcomes in acute myocardial infarction patients undergoing primary percutaneous coronary intervention (2020 ...
CLEVELAND, July 20, 2011 /PRNewswire/ -- One of Frantz Medical Groups (FMG) subsidiaries, VasoStar Inc., Mentor, Ohio today announced that it has been awarded an Ohio Third Frontier grant to further develop and commercialize a novel electromagnetic guidewire system for penetrating through vascular Chronic Total Occlusions (CTOs), in lieu of invasive open heart surgery such as Coronary Artery Bypass Graft (CABG). VasoStars primary clinical development partner is the Cleveland Clinics Lerner Research Institute. The VasoStar advisory team consists of world renowned cardiovascular clinicians including Dr. Patrick Whitlow, Director of Interventional Cardiology, Cleveland Clinic; Dr. Kiyo Fukamachi, Director of the Cardiovascular Dynamics Laboratory, Lerner Research Institute, Cleveland Clinic; Dr. Marc Penn, Director of Research, Summa Cardiovascular Institute; and Dr. Peter Fitzgerald, Director of the Center for Cardiovascular Technology and Director of the Cardiovascular Core Analysis Laboratory ...
A guidewire having a flexible coil with a tapered distal tip. Preferably, the flexible coil has a polymer coating at least at its tapered distal portion. The polymer coating may comprise polyurethanes or other suitable polymers. The guidewires of the invention provide desirable performance characteristics, particularly when used to cross relatively tight lesions such as chronic total occlusions.
Medical excimer laser developer Ra Medical said it won FDA 510(k) clearance for its Dabra system designed to treat patients with peripheral artery disease.. The Carlsbad, Calif.-based company said that the system is designed to destroy arteriosclerotic blockages through the use of radiation ablation, touting the device and associated procedures as cost and time saving.. Dabras pivotal study demonstrated 95% success without any clinically significant adverse events. Furthermore, the Dabra Catheter is unique in its ability to cross Chronic Total Occlusions without having to cross the lesion with a wire, and it also debulks and modifies arterial blockages, making it an invaluable clinical tool, Dr. Ehtisham Mahmud of the UC San Diego School of Medicine. Dabra is what we have been waiting for to better treat our patients. It is a two-in-one. You cross the blockage and remove the plaque from the artery. It is safe, because it stays in the patients true lumen and does not go subintimal or ...
The Jetstream Navitus offers greater flexibility, unsurpassed cutting effectiveness and improved guidewire performances. This catheter is a highly effective option for treating calcium blockages and chronic total occlusions in the peripheral vascular disease patient population.. The Jetstream Navitus offers interventionalists an evolutionary new tool to treat the most calcified lesions in the infra-inguinal vascular space, said Andrey Espinoza, medical director, Hunterdon Medical Center, New Jersey, USA. The design iterations provide a superior cutting platform with enhanced flexibility and an excellent deliverability profile. The Jetstream Navitus will allow a wider spectrum of patients to benefit from this generational technology.. Jetstream Navitus features: • Improved performance in tortuous anatomy-Enhanced drive line design provides for coaxial guidewire movement through the length of the catheter, offering enhanced flexibility, reduced friction and smooth movement through the ...
A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheters rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheaths helical grooves or slots against the cutting heads protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.
Though endovascular interventions for venous obstructive lesions have evolved, chronic total occlusions are difficult to negotiate. We are describing our experience of su..
Provided herein is a copolymer that includes a soft block (A) and a hard block (B) comprising a tyrosine di-peptide. The copolymer can be any of AB, ABA or BAB type block copolymers. The soft block can include a PEA polymer. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.
Dr. Shariq Shamim is a Board Certified Interventional Cardiologist who was named one of the top cardiologists in America in 2017 by Consumer Research Council of America. He is fellowship trained in Interventional Cardiology and in Cardiovascular Disease. He has a special interest in Chronic Total Occlusion PCI and Limb Salvage Interventions to improve patients quality of life. His philosophy is several cardiac issues are preventable and strongly believes in lifestyle and diet interventions to prevent these. Dr. Shamim is proud to be a part of the New Mexico Cardiac Care team and the community of Las Cruces.. ...
Computer-assisted image segmentation can be a challenging problem. In previous research, manual segmentation was used for the detection of key features in cervical and lumbar x-ray images. In this research, a semi-automated live wire technique is investigated and is evaluated for the detection of anterior osteophytes in lumbar vertebrae--Abstract, leaf iii.
A coronary occlusion is the partial or complete obstruction of blood flow in a coronary artery. This condition may cause a heart attack. In some patients coronary occlusion causes only mild pain, tightness or vague discomfort which may be ignored; however, the myocardium, the muscle tissue of the heart, may be damaged. According to Robert K. Massies Nicholas and Alexandra: The Fall of the Romanov Dynasty, Tsar Nicholas II may have suffered a coronary occlusion right before he was toppled from his throne during the Russian Revolution in 1917. Arterial embolism Massie, Robert K. (2012), Nicholas and Alexandra: The Fall of the Romanov Dynasty. New York, The Modern Library, p. 433. ISBN 0679645616. Accessed 2016-11-19. Originally published in 1967 by Artheneum (United States) as Nicholas and Alexandra: An Intimate Account of the Last of the Romanovs and the Fall of Imperial Russia. ISBN 978-0-679-64561-0 ...
News and information on minimally invasive coronary disease therapies, covering valvular, structural, radial access, chronic total occlusion, and imaging issues.
Roly has undertaken two interventional fellowships, firstly locally at Princess Alexandra Hospital in Brisbane. He was then awarded the Chamberlain Scholarship in Advanced Coronary and Structural Intervention at the world renowned Royal Sussex County Hospital, England. During his time there Roly was involved in many international trials and several first-in-man developments. Rolys main interest is in clinical cardiology with a focus on coronary and structural intervention. Unusually for an interventional cardiologist, Roly is also trained, accredited and performs cardiac CT giving a unique perspective in the diagnosis, investigation and management of cardiovascular diseases. Roly performs a wide range of percutaneous interventional procedures including coronary stents, rotablation and chronic total occlusion revascularisation. He performs the full range of structural interventions including TAVI, PFO / ASD closure, percutaneous treatments of aortic and mitral valves, left atrial appendage ...
BACKGROUND: Total occlusion of the infrarenal abdominal aorta is a very rare disease in clinical practice. The clinical outcome may be poor unless management is attempted promptly. Surgical bypass has been recommended as the treatment of choice for these lesions. However, there was relatively high surgical mortality and morbidity associad with aorto-bifemoral bypass graft in patients with other systemic disease, especially coronary artery disease. As a result, the use of, thrombolysis with percutaneous transluminal angioplasty (PTA) has recently been extended to this disease as an alternative method to surgery. PTA is technically simpler with less morbidity and mortality than surgery.We report our experience with thrombolysis and balloon angioplasty of total aortic occlusion in 14 patients between March 1991 and December 1996. METHODS: Fourteen patients, whose mean age was 59+/-13 years (11 male, 3 female), serve as the studys patients. Aortography was introduced via transbrachial artery. The ...
Approach and Results-Rats underwent transient, repetitive left anterior descending occlusion (resultant myocardial ischemia [RI]) for 0 to 10 days. CCG was measured in the collateral-dependent and normal zones using microspheres, MMP activation by Western blot, and endostatin and angiostatin by ELISA on days 0, 3, 6, 9, or 10 of RI. Endostatin and angiostatin were increased in JCR but not in Sprague Dawley rats on days 6 and 9 of RI. Increased endostatin and angiostatin correlated with increased MMP12 (≈4-fold) activation in JCR but not in Sprague Dawley rats on days 6 and 9 of RI. Inhibition of MMP12 in JCR rats nearly completely blocked endostatin (≈85%) and angiostatin (≈90%) generation and significantly improved CCG (collateral-dependent zone flow was ≈66% of normal zone flow versus ≈12% for JCR RI).. ...
Intravascular imaging catheters are provided that include a distal sheath portion having a lumen that is configured to optionally receive a guidewire or an imaging assembly. The distal sheath portion may be configured to have dimensions such that when a guidewire is inserted through the lumen and extends through a distal exit port, the distal sheath portion may be employed as a microcatheter. External tissue may be imaged at a location at or near the distal end of the catheter, enabling, for example, the controlled imaging of a total occlusion, and the positioning of the distal end (and guidewire) within a true lumen associated with a total occlusion. A structural stop may be provided at or near the distal end of the distal sheath portion to prohibit extension of the imaging assembly out of the distal exit port, while permitting the extension of the guidewire through the distal exit port.
For patients with type 2 diabetes and coronary artery disease, CABG plus optimal medical therapy is superior to PCI plus optimal medical therapy.
Join Adam Crespi for an in-depth discussion in this video Fine-tuning ambient occlusion and bounced light, part of Unity: Materials and Lighting
Brownell and J. Edgar Hoover"; of a coronary occlusion; in-his Manhattan apartment. Statement issued by the Julius and Ethel ...
Ischemic events during coronary artery balloon occlusion. In: Rutishauser W, Roskamm H, eds. Silent Myocardial Ischemia. Berlin ... Coronary Stents, Springer 1992 (ISBN 9780387545417) (Coronary Stents) U. Sigwart: Endoluminal Stenting, W. B. Saunders 1996 ( ... Coronary artery bypass surgery versus percutaneous coronary intervention with stent implantation in patients with multivessel ... a landmark paper on the use intravascular stents in humans to prevent occlusion and re-stenosis after angioplasty of coronary ...
Bramwell, C. (12 April 1930). "A British Medical Association Lecture on Coronary Occlusion". Br Med J. 1 (3614): 681-685. doi: ...
Onus died in 1968 of a coronary occlusion. Eckersley, M. 2012. Australian Indigenous Drama. Tasman Press. Altona. "Onus, ...
He died of coronary occlusion at age 49. Fewster played for the Yankees in the 1921 World Series. He was the first player to ...
He died in 1956 of a coronary occlusion. Lawrence, T. F. C. "Upton, Thomas Haynes (1889-1956)". Australian Dictionary of ...
He died in 1962, from a coronary occlusion. Australian Dictionary of Biography, online Lane, Richard (2000). The Golden Age of ...
He died of coronary occlusion in Mt. Lebanon, Pennsylvania. Pennsylvania portal Biography portal District Attorney Pittsburgh ...
... (February 1943). "The Electrocardiographic Diagnosis and Treatment in Recent Coronary Occlusion". Journal ... Harvey N. Middleton (July 1947). "Electrocardiographic Diagnosis and Prognosis of Recent Coronary Thrombosis or Occlusion". ... "Electrocardiographic Diagnosis and Prognosis of Recent Coronary Thrombosis or Occlusion", Journal of the Indiana State Medical ... "The Electrocardiographic Diagnosis and Treatment in Recent Coronary Occlusion", Journal of the Indiana State Medical ...
Ivins died in Salt Lake City of a coronary occlusion. He was buried at Salt Lake City Cemetery. Grave marker of Anthony W. ...
In 1979, Finklea survived a coronary occlusion and bypass surgery. He had a second coronary occlusion and repeated bypass ...
He died of a coronary occlusion on 22 February 1959. List of Olympic medalists in swimming (men) World record progression 4 × ...
He died at Salt Lake City of a coronary occlusion. State of Utah Death Certificate S. Dilworth Young, "The Seventies: A ...
Dougall died in Salt Lake City of a coronary occlusion. She was the mother of three children. Descendants of Brigham Young " ...
Shanks died of a coronary occlusion on July 30, 1941. He was survived by his wife and three siblings. List of Major League ...
Stern died suddenly on March 27, 1938 of coronary occlusion. Stern studied at the University of Berlin under the guidance of ...
An autopsy showed nearly complete occlusion of the main coronary arteries. In accordance with his wishes, his body was cremated ...
He died of a coronary occlusion in Fort Worth leaving two sons and a former wife. Self-taught, he learned to play the trumpet ... Coronary occlusion CS1 maint: discouraged parameter (link) "004478201". Standard Certificate of Birth (Microfilm) (Report). ...
Whitta died at his home in Darebin from a coronary occlusion. It was reported that he had just driven his wife and two sons ...
March 5, 1950: Showman Sid Grauman died of a coronary occlusion. May 29, 1951: Comedienne Fanny Brice died of a cerebral ...
He died of coronary occlusion on June 8, 1936, in Gloucester, Massachusetts. He married Natalie Harris (1859 - 1931), of ...
He died at age 42 in Sandusky, Ohio, of a coronary occlusion. "Cliff Fannin". baseball-reference.com. Retrieved 15 February ...
O'Sullivan died unexpectedly of a coronary occlusion while visiting Sydney in 1968. He was survived by his wife and two sons. ...
Nicholas had suffered a coronary occlusion only four days before his abdication. At the end of the "February Revolution", ...
The cause of death was a coronary occlusion, causing a heart attack. Associates in the Chicago Outfit took charge of his ...
"Widow of Automobile Pioneer, Victim of Coronary Occlusion, Survived Him Three Years". Associated Press. September 29, 1950. " ...
... , namely coronary ostial stenosis, is the occlusion of coronary ostium. Causing factors include atherosclerosis, ... Angelini, P (2012). "Congenital Coronary Artery Ostial Disease". Tex Heart Inst J. 39 (1): 55-9. PMC 3298900. PMID 22412228.. ...
Bannan died of a coronary occlusion on 26 July 1977 in Ballina. "Centenary Ball For "Fortians"". The Sydney Morning Herald. ...
When examined, it was determined that he had suffered a coronary occlusion. The deceased governor was provided a state funeral ...
She later died at 79 years of age of a coronary occlusion. She attended the State Normal School in Albany and in 1883, ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ...
Left atrial appendage occlusion[edit]. There is tentative evidence that left atrial appendage occlusion therapy may reduce the ... In men, coronary disease is more frequent, while in women, high systolic blood pressure and valvular heart disease are more ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ... Cardiovascular factors known to be associated with the development of AF include high blood pressure, coronary artery disease, ...
A vascular occlusion test (VOT) can be employed to assess microvascular function. Common sites for peripheral NIRS monitoring ... as well as coronaries. ...
In contrast, occlusion of the blood vessel by atherosclerotic plaque, by an embolised blood clot or a foreign body leads to ... Vessel occlusion tends to be a positive feedback system; an occluded vessel creates eddies in the normally laminar flow or plug ... Right coronary: *SA nodal. *AV nodal. *Atrial. *Right marginal. *Posterior interventricular. *Left coronary: *Anterior ...
... allowing radiologists to assess the extent of occlusion in the coronary arteries, usually in order to diagnose coronary artery ... Coronary CT angiography (CTA): the use of CT to assess the coronary arteries of the heart. The subject receives an intravenous ... Coronary CT calcium scan: also used for the assessment of severity of coronary artery disease. Specifically, it looks for ... "Assessment of Agatston Coronary Artery Calcium Score Using Contrast-Enhanced CT Coronary Angiography". American Journal of ...
Usually in children(age,4), it affects large, medium, and small vessels, prominently the coronary arteries. Associated with a ... Angiograms of mesenteri or renal arteries in polyarteritis nodosa may show aneurysms, occlusions, and vascular wall ...
Dong Z, Zheng J (September 2017). "Anticoagulation after coronary stenting: a systemic review". British Medical Bulletin. 123 ( ... Cardiopulmonary bypass (or any other surgeries requiring temporary aortic occlusion)[28]. *Heart failure[29] ... following acute coronary syndrome". European Heart Journal. 32 (20): 2541-54. doi:10.1093/eurheartj/ehr334. PMC 3295208. PMID ... The development of letaxaban was discontinued for acute coronary syndrome in May 2011 following negative results from a Phase ...
"Coronary calcium as a predictor of coronary events in four racial or ethnic groups". N. Engl. J. Med. 358 (13): 1336-45. doi: ... Diagram of a myocardial infarction (2) of the tip of the anterior wall of the heart (an apical infarct) after occlusion (1) of ... 1995). "Prediction of coronary heart disease using risk factor categories". J Indian Med Assoc. 93 (8): 312-5. PMID 8713248.. ... 1974). "Diagonal ear-lobe crease: prevalence and implications as a coronary risk factor". N Engl J Med. 290 (11): 615-6. doi: ...
This combination of vessel occlusion and vascular remodeling once again increases the resistance to blood flow and so the ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... 20 mm Hg with pulmonary arterial occlusion pressure [PAOP] ≤ 15 mm Hg and pulmonary vascular resistance [PVR] , 3 Wood Units).[ ...
This may be aided by fibrinolytic drugs such as Tissue Plasminogen Activator (tPA) in instances of coronary artery occlusion. ... This drug is administered intravenously and can be used to dissolve blood clots in coronary vessels. However, streptokinase is ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ...
Central retinal vein occlusion and branch retinal vein occlusion: despite the name these conditions have much more in common ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Central and branch retinal vein occlusion does not benefit from anticoagulation in the way that other venous thromboses do.[4] ...
Staples versus sutures for closing leg wounds after vein graft harvesting for coronary artery bypass surgery PMID 20464762 ... Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion PMID 23440840 https://doi ... Pain relief for the removal of femoral sheath after percutaneous coronary intervention PMID 18843700 https://doi.org/10.1002/ ... Done Macular grid laser photocoagulation for branch retinal vein occlusion PMID 25961835 https://doi.org/10.1002/14651858. ...
venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... The posteromedial muscle ruptures more frequently because it only has one source of blood supply, hence RCA occlusion can cause ... Posteromedial muscle blood supply: right coronary artery - posterior interventricular artery (RCA). ... of inferior vena cava, valve of coronary sinus) → tricuspid valve → right ventricle (infundibulum, moderator band/septomarginal ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Mitral regurgitation may also occur as a result of ischemic heart disease (coronary artery disease) or non-ischemic heart ...
Coronary artery bypass surgery[mag-edit , alilan ya ing pikuwanan]. Pun bulung: Coronary artery bypass graft surgery ... Diagram of a myocardial infarction (2) of the tip of the anterior wall of the heart (an apical infarct) after occlusion (1) of ... Coronary artery bypass surgery during mobilization (freeing) of the right coronary artery from its surrounding tissue, adipose ... Thrombus material (in a cup, upper left corner) removed from a coronary artery during a percutaneous coronary intervention to ...
In deep vein thrombosis this manifests as pain, redness, and swelling; in retinal vein occlusion this may result in macular ... often due to the obstruction of a coronary artery by a thrombus. This restriction gives an insufficient supply of oxygen to the ... Alternatively, arterial occlusion occurs as a consequence of embolism of blood clots originating from the heart ("cardiogenic" ... For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will ...
I65) Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction *(I65.0) Occlusion and stenosis of ... Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ... I65.2) Occlusion and stenosis of carotid artery. *(I65.3) Occlusion and stenosis of multiple and bilateral precerebral arteries ... I66) Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction *(I66.0) Occlusion and stenosis of ...
Bevantolol and N-Dimethyl Propranolol on Infarct Size Following Coronary Artery Occlusion in Anesthetized Dogs". Cardiology.. ...
... which results from an occlusion of one of the major coronary arteries, is currently still the leading cause of morbidity and ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... This surgery had not been possible prior to 1975 because of difficulty with re-implanting coronary arteries which perfuse the ...
Variable degrees of hemolysis and intermittent episodes of vascular occlusion resulting in tissue ischemia and acute and ... Elevation of both serum cholesterol and triglycerides; accelerated atherosclerosis, coronary heart disease; cutaneous xanthomas ... Independent risk factor for coronary artery disease, ischemic stroke, venous thrombosis (including osteonecrosis) ...
Coronary circulationEdit. Main article: Coronary circulation. Coronary circulation is the circulation of blood in the blood ... they can inflate the balloon at the occlusion site in the vascular system to flatten or compress the plaque against the ... Coronary artery diseaseEdit. Main article: Coronary artery disease. Coronary artery disease, also known as "ischemic heart ... As the left and right coronary arteries run on the surface of the heart, they can be called epicardial coronary arteries. These ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Among them was an open repair of an atrial septal defect using hypothermia, inflow occlusion and direct vision in a 5-year old ... He ligated a bleeding coronary artery in a 24-year-old man who had been stabbed in the left axilla and was in deep shock upon ... 2001). "Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery". N Engl J Med. 344 (6): 395- ...
... and concluded that Lunceford died of coronary occlusion.[15]. Lunceford had complained about an aching leg as they arrived in ...
In the coronary circulation, angiography of coronary artery responses to vasoactive agents may be used to test for endothelial ... function, and venous occlusion plethysmography and ultrasonography are used to assess endothelial function of peripheral ... specificity to diagnose coronary artery disease when compared against the gold standard, acetylcholine angiogram.[10] This ... "Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia". J Am ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ...
A more severe form is chronic total occlusion (CTO) when a coronary artery is completely obstructed for more than 3 months.[52] ... Coronary artery bypass grafting (CABG). Medications[edit]. *Statins, which reduce cholesterol, reduce the risk of coronary ... Percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG)[10]. Medication. Aspirin, beta blockers, ... Coronary artery disease. Synonyms. Atherosclerotic heart disease,[1] atherosclerotic vascular disease,[2] coronary heart ...
A coronary occlusion is the partial or complete obstruction of blood flow in a coronary artery. This condition may cause a ... In some patients coronary occlusion causes only mild pain, tightness or vague discomfort which may be ignored; however, the ... Tsar Nicholas II may have suffered a coronary occlusion right before he was toppled from his throne during the Russian ...
Purchase Manual of Coronary Chronic Total Occlusion Interventions - 1st Edition. Print Book & E-Book. ISBN 9780124201293, ... Manual of Coronary Chronic Total Occlusion Interventions 1st Edition. A Step-by-Step Approach. 3 Reviews ... Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach is a practical, easy to read reference for ... case-oriented and easy to read reference with illustrations and step-by-step guidance for coronary chronic total occlusion ...
Management of acute coronary occlusion during coronary angioplasty. BMJ 1990; 300 :1016 ... Management of acute coronary occlusion during coronary angioplasty.. BMJ 1990; 300 doi: https://doi.org/10.1136/bmj.300.6730. ...
Chronic coronary total occlusion is a block in the arteries lasting more than three months and can be treated with a variety of ... What Is Chronic Coronary Total Occlusion?. Chronic coronary total occlusion (CTO) occurs when either the left main or right ... Chronic coronary total occlusion symptoms. During the early stages of chronic coronary total occlusion (CTO), there may be no ... Chronic Coronary Total Occlusion Treatment. Chronic coronary total occlusion (CTO) treatment aims to restore blood flow through ...
The purpose of the present study was to assess whether brief, repeated coronary artery occlusions during balloon angioplasty ... In animals, brief coronary artery occlusions preceding a more prolonged occlusion result in reduced infarct size. Whether ... Repeated coronary artery occlusions during routine balloon angioplasty do not induce myocardial preconditioning in humans. * ... The purpose of the present study was to assess whether brief, repeated coronary artery occlusions during balloon angioplasty ...
For patients with limiting angina in spite of medical therapy coronary revascularisation either by coronary artery bypass ... grafting (CABG) or percutaneous coronary intervention (PCI) is extremely... ... Developments in coronary chronic total occlusion percutaneous coronary interventions: 2014 state-of-the-art update. J Invasive ... These include a patients presenting coronary syndrome, their co-morbidities and their coronary anatomy. Coronary artery ...
Percutaneous coronary intervention in chronic total occlusion is a rapidly evolving area, being considered the last frontier of ... Coronary Occlusion. Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS ... "Percutaneous Coronary Intervention in Chronic Total Occlusion.". Percutaneous coronary intervention in chronic total occlusion ... Percutaneous Coronary Intervention. A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including ...
These tracers were injected simultaneously with release of the coronary occlusion or after 5 or 20 min of reflow of coronary ... The "No-Reflow" Phenomenon after Temporary Coronary Occlusion in the Dog. Robert A. Kloner, Charles E. Ganote, and Robert B. ... phenomenon was investigated in the left ventricular myocardium of dogs subjected to temporary occlusions of a major coronary ... were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. ...
Coronary Artery Occlusion, Chelation and Cholesterol in a 49-year Old Pilot. Yaseem Sarwar PhD1 min read ... the angiogram showed that his coronary artery system was totally normal and there were no blockages anywhere in the coronary ... He underwent heart catheterization and was found to have his left main anterior descending coronary artery completely blocked. ...
Although ameroid constrictors have been used to create CTOs from extrinsic compression of coronary arteries, this model is not ... of coronary arteries represents a challenge for percutaneous treatment. ... Coronary Angiography. Coronary Disease / pathology, radiography, surgery*. Coronary Vessels / pathology, surgery. Disease ... OBJECTIVE: Chronic total occlusion (CTO) of coronary arteries represents a challenge for percutaneous treatment. Although ...
A, Ostium analysis of distribution of acute coronary occlusions. B, Normalized segment analysis of acute coronary occlusions. C ... A, Ostium analysis of distribution of acute coronary occlusions. B, Normalized segment analysis of acute coronary occlusions. C ... A, Ostium analysis of distribution of acute coronary occlusions. B, Normalized segment analysis of acute coronary occlusions. C ... Coronary Heart Disease. Coronary Artery Spatial Distribution of Acute Myocardial Infarction Occlusions. John C. Wang, Sharon- ...
... is a complete blockage of a coronary artery that has been in place for 30 or more days. ... What is a Coronary Artery Chronic Total Occlusion?. A coronary artery chronic total occlusion (CTO) is a complete blockage of a ... Coronary Artery Chronic Total Occlusion Institutes & Services , TriHealth Heart Institute Start of Coronary Artery Chronic ... How is Coronary Artery Chronic Total Occlusion Treated at Trihealth?. To diagnose a CTO, a routine physical exam with a careful ...
Figure 2: Coronary angiography. (a) Normal left coronary artery; (b) proximal occlusion of anomalous right coronary artery ( ... to left anterior descending coronary artery thrombotic occlusion and is rarely seen in proximal right coronary occlusion [4]. ... S. E. Kim, J.-H. Lee, D.-G. Park, K.-R. Han, and D.-J. Oh, "Acute myocardial infarction by right coronary artery occlusion ... Acute coronary syndrome with precordial ST segment elevation is usually related to left anterior descending artery occlusion, ...
Coronary Artery Disease. Myocardial Ischemia. Coronary Disease. Coronary Stenosis. Coronary Occlusion. Heart Diseases. ... Coronary Artery Disease Coronary Disease Coronary Stenosis Device: sirolimus-eluting stent Phase 3 ... Sirolimus-Eluting Stents for Chronic Total Coronary Occlusions. The safety and scientific validity of this study is the ... Percutaneous coronary intervention of chronic total occlusions (CTO), however, is still limited by high restenosis rates. ...
The article considers the screening for coronary artery occlusion for patients with non-ST elevation acute coronary syndromes ( ... A study revealed that about a quarter of patients with NSTEACS suffer from a coronary artery occlusion, specially in arteries ... The article presents a clinical case of a 39-year-old immigrant who was diagnosed of having a risk of coronary heart disease ( ... Use of the treadmill test in the diagnosis of coronary artery disease in patients with chest pain. Goldschlager, Nora; ...
"Reverse coronary steal" induced by coronary vasoconstriction following coronary artery occlusion in dogs.. M Chiariello, L G ... Reverse coronary steal induced by coronary vasoconstriction following coronary artery occlusion in dogs. ... "Reverse coronary steal" induced by coronary vasoconstriction following coronary artery occlusion in dogs. ... "Reverse coronary steal" induced by coronary vasoconstriction following coronary artery occlusion in dogs. ...
THE ROLE OF HYPERTENSION IN THE ETIOLOGY AND PROGNOSIS OF CORONARY OCCLUSION1 Annals of Internal Medicine; 42 (2): 369-377 ... THE RELATIONSHIP BETWEEN HYPERTENSION AND CORONARY OCCLUSION1 FRANZ GOLDSTEIN, M.D.; WILLIAM K. JENSON, M.D.; JEROME M. WALDRON ... THE RELATIONSHIP BETWEEN HYPERTENSION AND CORONARY OCCLUSION1. Ann Intern Med. 1956;44:446-455. doi: 10.7326/0003-4819-44-3-446 ... Alcohol Consumption and Risk for Coronary Heart Disease among Men with Hypertension Annals of Internal Medicine; 146 (1): I-35 ...
... occlusion 2.6 +/- 0.3; cocaine 5.2 +/- 0.7, occlusion 1.3 +/- 0.5 ln s2) response to 2-min coronary occlusion. beta- ... To test this hypothesis, we produced a 2-min left circumflex coronary artery (LCX) occlusion in unanesthetized mongrel dogs (n ... Effects of cocaine on cardiac vagal tone before and during coronary artery occlusion: cocaine exacerbates the autonomic ... occlusion 149.7 +/- 9.6; cocaine 144 +/- 11.9, occlusion 178.3 +/- 10.4 beats/min) and vagal tone (control 5.6 +/- 0.7, ...
Atrial Fibrillation and Coronary Artery Disease as Risk Factors of Retinal Artery Occlusion: A Nationwide Population-Based ... plays roles in later retinal artery occlusion (RAO) development and examine their relative weights. The relative risks of RAO ...
Aspirin dosage for the prevention of graft occlusion in people undergoing coronary surgery. To evaluate the use of different ... Aspirin dosage for the prevention of graft occlusion in people undergoing coronary surgery. Cochrane Database of Systematic ... dose regimens of aspirin to prevent graft occlusion in people who have undergone coronary artery bypass grafting. ... There is not enough evidence to show that lowering body temperature can reduce nerve damage during coronary artery bypass ...
Radial Artery Spasm Leading to Occlusion in Patients Undergoing Coronary Angiogram Via Radial Access. The safety and scientific ... Development of radial artery occlusion in patients who had spasm during coronary angiogram [ Time Frame: 30 days ]. ... Radial artery occlusion (RAO) is a frequent complication of radial artery cannulation. In the perioperative period, rates of ... Radial artery occlusion can be documented by an abnormal Barbeaus test , visible obstruction on two-dimensional ultrasound or ...
Acute thrombotic occlusion of the right coronary artery treated successfully with a helical thrombectomy device ... Acute thrombotic occlusion of the right coronary artery treated successfully with a helical thrombectomy device ... In these figures we illustrate the successful removal of visible occlusive thrombus from the right coronary artery with a new ... of plaque rupture or fissure is increasingly recognised to be the pivotal event in the pathogenesis of acute coronary syndromes ...
2012) Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions Registry. J ... and long-term outcomes of percutaneous coronary interventions for chronic coronary artery total occlusions: insights from the ... Since 2005, coronary chronic total occlusions (CTO) have been referred to as the "final frontier" in interventional cardiology ... 2012) A percutaneous treatment algorithm for crossing coronary chronic total occlusions. J Am Coll Cardiol Intv 5:367-379. ...
Blood Supply of the Myocardium after Temporary Coronary Occlusion. ARNO KRUG, WOLFGANG DU MESNIL DE ROCHEMONT, GERHARD KORB ... Blood Supply of the Myocardium after Temporary Coronary Occlusion. ARNO KRUG, WOLFGANG DU MESNIL DE ROCHEMONT and GERHARD KORB ... Blood Supply of the Myocardium after Temporary Coronary Occlusion. ARNO KRUG, WOLFGANG DU MESNIL DE ROCHEMONT and GERHARD KORB ... Resumption of circulation in the deeper layers of the RSCA was delayed after a prior coronary occlusion, even occasionally ...
Coronary Artery Bypass*Coronary Stent*Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI)*Electrocardiogram ( ... Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI). Chronic Total Occlusion Percutaneous Coronary ... Heart and Vascular Care / Heart and Vascular Procedures and Tests / Chronic Total Occlusion Percutaneous Coronary Intervention ... or complete blockages of the coronary arteries. CTOs are blockages that have been present for more than three months. During ...
We report on a patient suffering a branch retinal artery occlusion immediately following percutaneous transluminal coronary ...
To assess the acute effects of single and repeated coronary artery occlusions, during percutaneous transluminal coronary ... Effects of acute coronary occlusion and previous ischaemic injury on left ventricular wall motion in humans. ... Effects of acute coronary occlusion and previous ischaemic injury on left ventricular wall motion in humans. ... to the left anterior descending coronary artery (LAD) in 18 patients, native LAD or its vein graft in eight, and right coronary ...
... occlusion of extramural coronary arteries has not been reported. Also, only three cases with Noonan syndrome and congenital ... and extramural coronary artery narrowing have been found in patients with hypertrophic cardiomyopathy, ... We report a patient with Noonan syndrome, hypertrophic cardiomyopathy, and complete occlusion of the proximal left coronary ... Coronary Stenosis / congenital*, diagnosis. Coronary Vessel Anomalies / complications, diagnosis. Humans. Male. Noonan Syndrome ...
Coronary Occlusion. Coronary Disease. Myocardial Ischemia. Heart Diseases. Cardiovascular Diseases. Vascular Diseases. ... Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions. The safety and ... Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions. ... Patient with coronary lesions amenable to percutaneous coronary intervention including brachytherapy, or where CABG is ...
Modification of Myocardial Infarction Size After Coronary Occlusion Annals of Internal Medicine; 79 (5): 720-733 ... The advent of the anticoagulants in the treatment of coronary occlusion was received with almost universal enthusiasm when the ... and they have implied that the use of anticoagulants in patients with impending coronary occlusion or with ... ANTICOAGULANT THERAPY TO PREVENT MYOCARDIAL INFARCTION IN PATIENTS WITH PREMONITORY SYMPTOMS OF AN IMPENDING CORONARY OCCLUSION ...
  • Repeated coronary artery occlusions durin. (mendeley.com)
  • The purpose of the present study was to assess whether brief, repeated coronary artery occlusions during balloon angioplasty induce a myocardial ischemic protective effect. (mendeley.com)
  • OBJECTIVE: To assess the acute effects of single and repeated coronary artery occlusions, during percutaneous transluminal coronary angioplasty (PTCA), on left ventricular long axis function in patients with stable and unstable angina. (bmj.com)
  • Management of acute coronary occlusion during coronary angioplasty. (bmj.com)
  • Johnston R T , Reek C , Spyt T J . Management of acute coronary occlusion during coronary angioplasty. (bmj.com)
  • Thirteen patients with a proximal left anterior descending coronary artery stenosis with no angiographic collateral circulation underwent percutaneous transluminal coronary artery balloon angioplasty. (mendeley.com)
  • In patients with proximal left anterior descending coronary artery stenosis and no evidence of collateral circulation, brief periods of ischemia, such as those used during routine coronary balloon angioplasty, do not provide any protection against myocardial ischemia. (mendeley.com)
  • A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g. (bioportfolio.com)
  • Although ameroid constrictors have been used to create CTOs from extrinsic compression of coronary arteries, this model is not suitable for evaluation of novel angioplasty equipment. (biomedsearch.com)
  • We describe a case in which precordial ST elevation occurred in a patient with proximal right coronary artery acute occlusion and was treated with coronary angioplasty. (hindawi.com)
  • Primary intracoronary stent placement after successfully crossing chronic total occlusions (CTO) decreases the high restenosis rate at long-term follow-up compared with conventional balloon angioplasty. (clinicaltrials.gov)
  • Since data from the 2 landmark studies, the BENESTENT and STRESS studies, showed that coronary stenting significantly decreases restenosis as compared with conventional balloon angioplasty, this treatment modality has shown to be superior in an increasing number of indications. (clinicaltrials.gov)
  • Branch retinal artery occlusion secondary to percutaneous transluminal coronary angioplasty. (bmj.com)
  • We report on a patient suffering a branch retinal artery occlusion immediately following percutaneous transluminal coronary angioplasty. (bmj.com)
  • Stent or Angioplasty After Recanalization of Chronic Coronary Occlusions (SARECCO) was a randomized multicenter trial in patients with chronic total coronary artery occlusions comparing stent implantation versus no further therapy following successful balloon angioplasty. (acc.org)
  • Stent implantation in patients successfully treated with balloon angioplasty for a chronic total occlusion of a coronary artery would be associated with higher rates of acute and long-term procedural success compared to balloon angioplasty alone. (acc.org)
  • After successful balloon angioplasty of a chronic (>1 week by history) totally occluded coronary artery, patients were randomized to receive stent implantation or no stent. (acc.org)
  • Among patients undergoing successful recanalization of chronic total occlusions with percutaneous transluminal coronary angioplasty, this randomized trial of stent implantation versus no further intervention by balloon angioplasty demonstrated that stent implantation was associated with greater MLD and less residual stenosis acutely. (acc.org)
  • Primary angioplasty and stenting of the right coronary artery lesion was performed with an excellent result (Figure 2). (eplabdigest.com)
  • Sometimes called a coronary angioplasty, the PCI process involves using a device comprised of guide wires and a catheter fitted with a balloon to break up the blockage, after which a small mesh tube called a stent is placed in the affected area to support the inner wall of the artery and help maintain blood flow. (uabmedicine.org)
  • Because abrupt occlusion of a coronary artery is a major cause of sudden cardiac death (13) and experimental studies suggest that low baroreflex sensitivity (BRS) is a marker of increased risk of ventricular fibrillation during acute coronary occlusion (14-16) , we assessed the effects of acute coronary occlusion on baroreflex control of the circulation in a prospective series of patients undergoing clinically indicated coronary angioplasty. (onlinejacc.org)
  • Objective To compare the prevalence of acute coronary occlusion and, in these cases, single time point biomarker estimates of myocardial infarct size between patients presenting with protocol positive ECG changes and those presenting with less diagnostic changes in the primary angioplasty cohort of an open access PPCI programme. (bmj.com)
  • Conclusions A number of patients referred to an open access PPCI programme have protocol negative ECGs but myocardial infarction and acute coronary artery occlusion amenable to angioplasty. (bmj.com)
  • Transluminal coronary angioplasty can serve as a model for controlled coronary artery occlusion and reperfusion which enables assessment of short-term changes in collateral vessel filling in patients with severe atherosclerotic coronary artery disease. (onlinejacc.org)
  • The influence of acute coronary occlusion on systolic and diastolic left ventricular pressure-volume relations was studied in 10 patients undergoing percutaneous transluminal coronary angioplasty (PTCA). (elsevier.com)
  • The present study was designed to determine the prognostic significance of the signal average electrocardiography and to evaluate the possible value of this technique as a noninvasive tool for monitoring of coronary occlusion and reperfusion. (koreamed.org)
  • METHODS: Signal averaging was performed by using a signal average electrocardiography with bidirectional filterings before coronary artery occlusion, at 5 minutes after coronary occlusion and on reperfusion in 20 cats. (koreamed.org)
  • All rats were subjected to 30 mins of left coronary artery occlusion followed by 48 hrs of reperfusion. (ovid.com)
  • During coronary occlusion and the reperfusion period, AIH resulted in a lower incidence of fatal ventricular tachyarrhythmia (17% vs. 50% in control group, p p (ovid.com)
  • Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs. (aspetjournals.org)
  • Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. (harvard.edu)
  • Rigid criteria may result in some patients with acutely occluded coronary arteries not receiving timely reperfusion therapy. (bmj.com)
  • Magnesium can protect myocardial tissue after coronary occlusion and reduces infarct size in experimental models of ischaemia and reperfusion, though the given doses of magnesium are relatively high and differ from clinically reachable serum concentrations. (elixirindustry.com)
  • Anaesthetized open chest dogs underwent 1 h of left anterior descending artery occlusion followed by 6 h of reperfusion. (elixirindustry.com)
  • 2. Fourteen animals received intravenous infusion with magnesium potassium aspartate (Mg-K i.v.) or vehicle infusion (control i.v.), beginning 1 h before occlusion until the end of the 6 h reperfusion period. (elixirindustry.com)
  • The best hope of salvaging viable myocardium after a coronary occlusion is by rapid reperfusion of the ischemic myocardium, either by thrombolysis or primary percutaneous coronary intervention. (oatext.com)
  • Postconditioning of the heart with brief episodes of reperfusion/occlusion at the onset of reflow has been shown to limit infarct size. (oatext.com)
  • These data indicate that pressure-volume analysis is useful in assessing the functional significance of coronary lesions and reperfusion. (elsevier.com)
  • A great majority of patients with ischemic symptoms and new LBBB do not have acute coronary occlusion and do not need immediate reperfusion therapy. (blogspot.com)
  • Postsystolic shortening of acutely ischemic canine myocardium predicts early and late recovery of function after coronary artery reperfusion. (semanticscholar.org)
  • Approximately 15 to 20 percent of people with coronary artery disease have a CTO. (upmc.com)
  • In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. (bioportfolio.com)
  • The effect of chronic kidney disease (CKD) on in-hospital outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. (bioportfolio.com)
  • The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on cardiac function in multi-vessel disease patients with concurrent chronic total occlus. (bioportfolio.com)
  • Use of the treadmill test in the diagnosis of coronary artery disease in patients with chest pain. (ebscohost.com)
  • The article presents a clinical case of a 39-year-old immigrant who was diagnosed of having a risk of coronary heart disease (CHD). (ebscohost.com)
  • Reports on the study about the frequency of diagnostic tests and therapeutic interventions for coronary heart disease among women. (ebscohost.com)
  • Relevance of gender on the diagnosis and treatment of coronary disease. (ebscohost.com)
  • Discusses the study `Diagonal earlobe creases and prognosis in patients with suspected coronary artery disease,' by W.J. Elliott and L.H. Powell. (ebscohost.com)
  • Focuses on the utilization of an arbutamine HCl injection (GenESA) system to diagnose coronary artery disease (CAD). (ebscohost.com)
  • We use Taiwanese national health insurance research database (NHIRD) to investigate whether thrombolism (carotid artery disease (CAD) as a surrogate) or embolism (atrial fibrillation (AF) as a surrogate) plays roles in later retinal artery occlusion (RAO) development and examine their relative weights. (hindawi.com)
  • SUBJECTS: 36 patients, age (SD) 60 (8) years, with significant coronary artery disease undergoing PTCA (mean duration 100-130 seconds) to the left anterior descending coronary artery (LAD) in 18 patients, native LAD or its vein graft in eight, and right coronary artery in 10. (bmj.com)
  • RESULTS-AT BASELINE: in systole, total long axis excursion was reduced at septal, posterior, and right sites in patients with LAD disease, at right site in those with vein grafts, and at septal and right sites in patients with right coronary artery disease. (bmj.com)
  • This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. (dovepress.com)
  • Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. (dovepress.com)
  • Acute coronary syndrome (ACS) is a common disease at emergency departments, and has high morbidity and mortality. (dovepress.com)
  • 4 To our knowledge, such a case has never been reported in a patient without known prior coronary disease. (eplabdigest.com)
  • One or more arteries with chronic total occlusion (CTO) are identified in approximately one-third of diagnostic coronary angiograms in patients with known or suspected coronary artery disease (1,2) . (onlinejacc.org)
  • A 45-year-old previously healthy man with minimal coronary artery disease on imaging presented with an acute MI after sustaining a wasp sting following previous non-eventful exposures throughout his life. (bmj.com)
  • P=0.0003) despite an increase in case complexity (previous myocardial infarction, diabetes, renal failure, previous coronary artery bypass grafting, peripheral vascular disease and left ventricular impairment) that correlated with procedural advancements. (ovid.com)
  • In 16 patients with isolated left anterior descending or right coronary artery disease (≥ 75% stenosis) and normal left ventricular function, collateral filling to the artery being dilated was visualized by contrast injection into the contralateral artery using a second arterial catheter. (onlinejacc.org)
  • What does coronary occlusion acute, arterio-sclerotic cardio vascular disease and acute myocardial infarction mean? (healthtap.com)
  • Arteriosclerotic cardiovascular disease means blockages in the coronary arteries. (healthtap.com)
  • Coronary artery disease, revascularization, and clinical outcomes in transcatheter aortic valve replacement: Real-world results from the East Denmark Heart Registry. (readbyqxmd.com)
  • The optimal treatment strategy for concomitant coronary artery disease (CAD) has not been tested prospectively in a randomized clinical trial. (readbyqxmd.com)
  • Coronary heart disease remains the leading cause of morbidity and mortality in Western countries. (oatext.com)
  • Lipids and in particular polyunsaturated fatty acids have received special cardiovascular research attention because polyunsaturated fatty acid-rich diets are associated with a decreased risk of coronary artery disease. (oatext.com)
  • Your medications are all prescribed in order to reduce the work of your heart, which is important in coronary artery disease. (healthunlocked.com)
  • Background: With the improved lifestyle of people, the incidence of coronary artery disease is gradually increasing. (scirp.org)
  • They were initially divided into two groups based on angiographic reports: single vessel disease (SVD) and non-single vessel disease (non-SVD) group, then into optimal medical therapy (OMT) group, percutaneous coronary intervention (PCI) group and coronary artery bypass graft (CABG) group. (scirp.org)
  • Coronary artery disease is the most common form of heart diseases. (scirp.org)
  • ABSTRACT Background Coronary chronic total occlusion is present in approximately one third of patients with coronary artery disease, and its management is challenging. (jotci.org)
  • Smoking was the only risk factor for coronary artery disease. (sch.ac.kr)
  • Coronary angiography revealed two-vessel coronary disease, with a thrombus and total occlusion of the middle right coronary artery (RCA) ( Fig. 2A ) and proximal left anterior descending artery (LAD). (sch.ac.kr)
  • If you or someone you love is diagnosed with coronary artery chronic total occlusion, the Northwestern Medicine Center for Coronary Disease offers leading-edge diagnostic testing as well as advanced medical and surgical treatment options. (nm.org)
  • The standard treatment for patients with obstructive left main coronary artery disease has typically been coronary-artery bypass grafting (CABG), however some newer trials have suggested that maybe drug-eluting stents may be an acceptable alternative to CABG in select patients. (rebelem.com)
  • The High-Risk Coronary Intervention Program at the Massachusetts General Hospital Corrigan Minehan Heart Center treats coronary artery disease, the blockage of the heart's arteries due to cholesterol build-up. (massgeneral.org)
  • 2008 Coronary Artery Disease, May Decrease The Risk Of Retinal Artery Occlusion. (webteksites.com)
  • Learn about the causes of coronary artery disease like vascular occlusion, etc. (cardiogod.com)
  • At first balloon inflation: the extent of pre-existing systolic and particularly diastolic abnormalities consistently increased in patients with LAD or right coronary artery occlusion. (bmj.com)
  • Of 215 patients, 39% had left anterior descending artery occlusion, 49% had right coronary artery occlusion, and 12% had left circumflex artery occlusion. (lu.se)
  • Safety and efficacy of dedicated guidewire and microcatheter technology for chronic total coronary occlusion revascularization: principal results of the Asahi Intecc Chronic Total Occlusion Study. (bioportfolio.com)
  • However, regarding indications, the multisociety-sponsored appropriate use criteria (AUC) for coronary revascularization (4) provide a useful construct for selecting patients, although these indications relate to revascularization, not PCI in particular, and have limitations that have been reviewed elsewhere (5) that are being addressed in the 2017 update. (onlinejacc.org)
  • Objectives This study explored whether cardiac magnetic resonance (CMR) could help select patients who could benefit from revascularization by identifying inducible myocardial ischemia and viability in the perfusion territory of the artery with chronic total occlusion (CTO). (onlinejacc.org)
  • Background The benefit of revascularization using percutaneous coronary intervention (PCI) in CTO is controversial. (onlinejacc.org)
  • The aim of this study was to determine the potential added value of guiding revascularization by quantitative assessment of myocardial perfusion prior to intervention.Methods and ResultsThirty-three patients (10 females) with suspected or established CAD who had been referred for a clinical coronary angiography (CA) with possibility for PCI were included. (medworm.com)
  • 1 They have been largely excluded from any randomized evaluation of the comparative efficacy of coronary revascularization strategies, coronary artery bypass grafting, or percutaneous coronary intervention (PCI). (ahajournals.org)
  • In general, percutaneous coronary revascularization is more complex and difficult to perform in hemodialysis patients 2 than in nonhemodialysis patients because of greater calcification and medial thickness of the coronary plaque. (ahajournals.org)
  • 3 Importantly, the presence of chronic total occlusion (CTO) is the strongest independent predictor of incomplete revascularization in patients undergoing PCI. (ahajournals.org)
  • Major adverse cardiac event (MACE) was defined as the composite of cardiac death, acute coronary syndrome, and target-vessel revascularization. (invasivecardiology.com)
  • ABSTRACT Background Chronic total occlusion is the subtype of lesions with the lowest procedural success rates, as well as the most common cause of incomplete revascularization and coronary artery bypass grafting. (jotci.org)
  • Background- Although a total coronary occlusion is identified approximately in one third of the diagnostic cardiac catheterizations , still an attempted revascularization of total occlusion accounts for less than 8% of all percutaneous coronary interventions (PCI). (bvsalud.org)
  • Increased interest focusing on coronary chronic total occlusions has emerged since several studies have proven improved cardiovascular outcomes and quality of life after successful chronic total occlusion (CTO) revascularization. (clinmedjournals.org)
  • Increased interest focusing on coronarychronic total occlusions has emerged since several studies have proven improved cardiovascular outcomes and quality of life after successful revascularization of achronic total occlusion (CTO) [ 1 ]. (clinmedjournals.org)
  • abstract = "The exact microvascular site of coronary vasodilation after coronary artery occlusion has not been clearly established. (elsevier.com)
  • abstract = "The coronary arteries of 100 patients were radiographically visualized by selective injection of contrast material. (elsevier.com)
  • RESULTS: Follow-up angiography prior to sacrifice revealed complete occlusion in 14 of 17 animals, with the subtotal occlusive lesions (mean 60% stenosis) only in the early group. (biomedsearch.com)
  • DESIGN: Prospective examination of ventricular systolic and diastolic long axis function using M mode echocardiography and transmitral Doppler in patients with significant coronary artery stenosis and either stable or unstable angina, during routine PTCA. (bmj.com)
  • There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. (dovepress.com)
  • These observations suggest that in a high percent of patients with severe coronary stenosis, collateral channel filling improves within 60 to 90 seconds after sudden coronary occlusion. (onlinejacc.org)
  • We sought to determine 1) the microvascular site of recruitable vasodilator reserve after a critical stenosis as assessed by adenosine and EDTA, 2) the coronary microvascular site responsible for vasodilatation after total coronary artery occlusion, and 3) the microvascular site for recruitable vasodilator reserve after coronary artery occlusion as assessed by adenosine and EDTA. (elsevier.com)
  • Hemodynamics and coronary epicardial microvascular diameter were measured in 33 dogs by means of intravital epi-illumination microscopy at control conditions, during a critical stenosis, or 30, 60, and 120 min following coronary artery occlusion. (elsevier.com)
  • We concluded that in response to sudden coronary artery occlusion, the coronary microvascular dilation was inversely related to the control microvascular diameter, and in contrast to the response after a critical stenosis, there was no pharmacologically recruitable vasodilator reserve to adenosine or EDTA following acute coronary artery occlusion. (elsevier.com)
  • Furthermore, the troponin elevation can be explained exertion in the presence of aortic stenosis, due to demand ischemia (or "type II" MI, not caused by acute coronary syndrome and thus not requiring intensive antiplatelet or antithrombotic therapy). (blogspot.com)
  • A minimal stenosis at the left main coronary artery was also observed ( Fig. 2B ). (sch.ac.kr)
  • Proximal coronary artery stenosis progressed to complete occlusion in almost half the patients on whose stenotic arteries a graft had been placed. (elsevier.com)
  • For patients with limiting angina in spite of medical therapy coronary revascularisation either by coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) is extremely efficacious for symptom relief. (springer.com)
  • To evaluate the use of different dose regimens of aspirin to prevent graft occlusion in people who have undergone coronary artery bypass grafting. (cochrane.org)
  • Treatment of CTO lesions remains a major challenge for interventional cardiology and is a frequent reason for a patient's referral to coronary artery bypass surgery (CABG) [ 1 ]. (omicsonline.org)
  • At one time, a coronary chronic total occlusion required coronary bypass surgery. (uabmedicine.org)
  • UAB is one of the first heart centers in the nation to use a new procedure called percutaneous coronary intervention of coronary chronic total occlusion, which allows many patients to avoid bypass surgery. (uabmedicine.org)
  • She then underwent single-vessel coronary artery bypass graft surgery in 2009 for recurrent ISR of a stent in the proximal LAD. (cathlabdigest.com)
  • Even though diabetes is associated with a greater incidence of comorbidities, after adjusting for prior bypass surgery , no significant differences in the success or safety of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) were demonstrated in patients with diabetes compared with those without diabetes, according to a prospective, multicenter study published in JACC: Cardiovascular Intervention . (endocrinologyadvisor.com)
  • A total of 592 consecutive patients with CTO in Beijing Friendship Hospital from June 2017 to December 2019 were enrolled, 29 patients were excluded due to Coronary artery bypass grafting (CABG). (researchsquare.com)
  • Although RAO is rarely accompanied by hand ischemia, it is an important complication because it prohibits future transradial access and radial artery utilization as a conduit for coronary artery bypass grafting or arteriovenous fistula formation. (radcliffecardiology.com)
  • Rösch, J. / Occlusion of coronary arteries after vein bypass . (elsevier.com)
  • Effects of cocaine on cardiac vagal tone before and during coronary artery occlusion: cocaine exacerbates the autonomic response to myocardial ischemia. (nih.gov)
  • The current initiative is to investigate a model of chronic myocardial ischemia and (1) to determine whether intra-coronary injection of selected autologous marrow-derived AC133 stem cells is reasonably safe for use in humans and (2) if this treatment shows any improvement in coronary perfusion, as assessed using non-invasive imaging. (clinicaltrials.gov)
  • In this respect, an increased arrhythmogenicity has been described in the border zone, 13 , 14 an area subjected to mechanical tension during regional ischemia, and also in association with spontaneous 15 , 16 , 17 or induced 13 , 18 left ventricular distension following coronary occlusion. (revespcardiol.org)
  • Myocardial perfusion single-photon emission computed tomography has been used to describe the coronary perfusion territories during myocardial ischemia. (lu.se)
  • If our hypothesis proves to be true, this would provide a significant improvement in the care for patients who present to the hospital with possible symptoms of coronary ischemia (symptoms due to lack of blood flow to the heart). (clinicaltrialslocator.com)
  • Myocardial perfusion scintigraphy demonstrated inferior ischemia and diagnostic coronary angiography showed a long CTO of the right coronary artery (RCA) and retrograde distal filling of RCA from septal collateral channels of left anterior descending artery (Figure 1). (clinmedjournals.org)
  • Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach is a practical, easy to read reference for coronary chronic total occlusion interventions (CTO). (elsevier.com)
  • Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, pitfalls to watch out for, and troubleshooting needed for coronary chronic total occlusion interventions (CTO). (elsevier.com)
  • A practical, case-oriented and easy to read reference with illustrations and step-by-step guidance for coronary chronic total occlusion interventions (CTO). (elsevier.com)
  • Chronic coronary total occlusion (CTO) occurs when a buildup of plaque blocks the coronary artery for more than 90 days, starving your heart of oxygen. (upmc.com)
  • Chronic coronary total occlusion (CTO) occurs when either the left main or right coronary artery - one of the arteries that delivers oxygen-rich blood to your heart - has become completely blocked or occluded for three months or longer. (upmc.com)
  • During the early stages of chronic coronary total occlusion (CTO), there may be no symptoms at all. (upmc.com)
  • Use of sodium nitroprusside in retrograde percutaneous coronary intervention for chronic total occlusion: A case report. (bioportfolio.com)
  • Chronic total occlusion continues to be a challenging lesion subset for percutaneous coronary intervention. (bioportfolio.com)
  • The atherogenic index of plasma and its impact on recanalization of chronic total occlusion. (bioportfolio.com)
  • Use of chronic total occlusion percutaneous coronary intervention techniques for treating acute vessel closure. (bioportfolio.com)
  • The aim of this study is to investigate the role of functional evaluation for predicting clinical outcome in patients with coronary chronic total occlusion (CTO) undergoing percutaneous co. (bioportfolio.com)
  • Under the circumstances that appropriate first-choice guidewires for percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) have yet to be established, the objective of. (bioportfolio.com)
  • The purpose of this project is to objectively assess the change (improvement) in exercise capacity in patients undergoing routine percutaneous coronary intervention (PCI) for chronic total. (bioportfolio.com)
  • A new percutaneous porcine coronary model of chronic total occlusion. (biomedsearch.com)
  • OBJECTIVE: Chronic total occlusion (CTO) of coronary arteries represents a challenge for percutaneous treatment. (biomedsearch.com)
  • Efficacy and safety of contrast injection beyond total occlusions in acute cardiac patients: a metho. (biomedsearch.com)
  • A coronary artery chronic total occlusion (CTO) is a complete blockage of a coronary artery that has been in place for 30 or more days. (trihealth.com)
  • How is Coronary Artery Chronic Total Occlusion Treated at Trihealth? (trihealth.com)
  • In this prospective randomized trial, bare metal stent implantation will be compared with sirolimus-eluting stent implantation for the treatment of chronic total coronary occlusions. (clinicaltrials.gov)
  • Percutaneous coronary intervention of chronic total occlusions (CTO), however, is still limited by high restenosis rates. (clinicaltrials.gov)
  • In this prospective, randomized, single-blind trial we enrolled 200 patients with chronic total occlusions: 100 were randomly assigned to receive bare metal BxVelocity™ stents, and 100 to receive sirolimus-eluting Cypher™ stents. (clinicaltrials.gov)
  • He was transferred to our hospital and angiography at approximately three hours post-thrombolysis showed a total acute occlusion of the culprit vessel. (bmj.com)
  • Since 2005, coronary chronic total occlusions (CTO) have been referred to as the "final frontier" in interventional cardiology (1) . (onlinejacc.org)
  • The American College of Cardiology/American Heart Association guideline for coronary intervention, section 4.7.1 provides a Class IIa rating for CTO PCI, stating that "PCI of a chronic total occlusion in patients with appropriate clinical indications and suitable anatomy is reasonable when performed by operators with appropriate expertise…(Level of Evidence: B)" (3) . (onlinejacc.org)
  • Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI) is a minimally invasive procedure to treat patients with chronic total occlusion, or complete blockages of the coronary arteries. (vanderbilthealth.com)
  • Potential candidates are patients with a known total occlusion of an epicardial vessel, with a documented chronically ischemic territory supplied by collateral conduits. (clinicaltrials.gov)
  • Objectives The aim of this study was to determine the techniques and outcomes of hybrid chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a diverse group of patients and operators on 2 continents. (onlinejacc.org)
  • Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Chronic Total Occlusion. (onmedica.com)
  • The optimal duration of dual antiplatelet therapy (DAPT) after treatment of chronic total occlusions (CTO) with percutaneous coronary intervention (PCI) is unknown. (onmedica.com)
  • Chronic total coronary occlusions (CTO) still remain one of the most technically challenging clinical scenarios in which to perform interventions. (omicsonline.org)
  • A coronary chronic total occlusion is a total blockage in a coronary artery that has been present for at least three months. (uabmedicine.org)
  • If the complete blockage has been present for less than three months, it is called a total coronary occlusion. (uabmedicine.org)
  • UAB is an active participant in research and clinical trials for the diagnosis and treatment of chronic total occlusion. (uabmedicine.org)
  • A control group of 11 patients treated for chronic total occlusion of a coronary artery was assessed to evaluate nonspecific changes in baroreflex function during a 2-min balloon inflation in the occluded artery. (onlinejacc.org)
  • Balloon inflation in a chronic total occlusion of a coronary artery did not cause significant changes in BRS (from 5.3 ± 4.0 to 5.2 ± 3.7 ms·mm Hg −1 ), correlation coefficient of the slope or phenylephrine-induced pressure rise. (onlinejacc.org)
  • AbstractBackgroundThe benefits of chronic coronary total occlusion (CTO) percutaneous coronary intervention (PCI) are being questioned. (medworm.com)
  • Change in quantitative (hyperemic) myocardial blood flow (MBF), coronary flow reserve (CFR) and perfusion defect size (in myocardial segments) were compared between CTOs and non ‐CTO lesions.ResultsIn total 92 patients with a CTO and 31 patients with a non ‐CTO lesion were included. (medworm.com)
  • Despite technical advancements, long-term outcomes after chronic total occlusion (CTO) recanalisation remain a subject of debate, especially in diabetic patients. (eurekamag.com)
  • Background Among patients treated with percutaneous coronary intervention for chronic total occlusion ( CTO ‐ PCI ), patients on long‐term hemodialysis are at significantly high risk for cardiovascular mortality and morbidity. (ahajournals.org)
  • Irrespective of clinical/angiographic characteristics or previously developed scoring systems, hemodialysis independently and strikingly predicted technical failure in percutaneous coronary intervention for chronic total occlusion. (ahajournals.org)
  • With regard to percutaneous coronary intervention for chronic total occlusion in hemodialysis patients, improvement in patient selection (as suggested in our article) would contribute to a higher technical success rate and wider use of complex percutaneous coronary intervention with dedicated devices and specialized techniques. (ahajournals.org)
  • Since publication of the hybrid algorithm for crossing coronary chronic total occlusions (CTO), use of the algorithm has been associated with increased CTO percutaneous coronary intervention (PCI) adoption, procedural efficiency, and success rates. (cathlabdigest.com)
  • Coronary chronic total occlusions (CTO) are the most challenging lesions to treat percutaneously. (iospress.com)
  • Percutaneous recanalization of chronic total occlusions: Wherein lies the body of proof? (deepdyve.com)
  • Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) of in-stent occlusions can be challenging. (invasivecardiology.com)
  • 61 yr old hypertensive male has total occlusion of right coronary andom.Stenting of om1 done. (healthtap.com)
  • 61 yr old hypertensive male has total occlusion of right coronary andom. (healthtap.com)
  • The impact of intravascular ultrasound (IVUS) utilization for stent optimization on the long-term outcomes in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. (invasivecardiology.com)
  • 2 Two randomized controlled trials have demonstrated that use of IVUS can improve long-term outcomes after chronic total occlusion (CTO)-PCI. (invasivecardiology.com)
  • If coronary artery chronic total occlusion (CTO) cuts off the supply of oxygen-rich blood to your heart, the result is a heart attack and your heart muscle begins to die. (nm.org)
  • The Angiogram showed a Total Coronary Occlusion of the right coronary artery. (healthunlocked.com)
  • You're right, a CTO is a total occlusion and can take longer than a normal PCI, as they have to try to get a guide wire through the occlusion in order to get a stent in. (healthunlocked.com)
  • Method: The patients who were diagnosed with chronic total occlusion (CTO) in our hospital within one year period have been included. (scirp.org)
  • The duration of occlusion should be more than 3 months, which can be estimated via initial onset of symptoms, or increased frequency of angina or previous history of myocardial infarction or total occlusion revealed by coronary angiography. (scirp.org)
  • The chronic total occlusion is basically a slow process. (scirp.org)
  • In this study, we have evaluated the procedural and clinical efficacy after PCI of CTO lesion and non-CTO lesion in patients with coronary chronic total occlusion. (scirp.org)
  • Coronary chronic total occlusions (CTOs) are correlated with increased risk of adverse clinical outcomes. (researchsquare.com)
  • Our goal is to characterize the most frequent complications in percutaneous treatment of chronic total occlusions in contemporary practice. (jotci.org)
  • The objective of this study was to present contemporary data on percutaneous coronary intervention in chronic total occlusions. (jotci.org)
  • A 39-year-old Korean man with simultaneous total occlusion of the left anterior descending artery and the right coronary artery presented with chest discomfort and cardiogenic shock. (sch.ac.kr)
  • Percutaneous Coronary Intervention (PCI) of chronic total occlusion (CTO) is one of the major challenges in interventional cardiology . (bvsalud.org)
  • 50 consecutive patients with chronic total occlusion undergoing PCI were included in the study. (bvsalud.org)
  • Coronary angiography displaying a long chronic total occlusion of the right coronary artery and retrograde distal filling from septal collateral channels of the left anterior descending artery (black arrow). (clinmedjournals.org)
  • Chronic total occlusion percutaneous coronary intervention (CTO-PCI) can improve angina and left ventricular ejection fraction (LVEF). (biomedcentral.com)
  • We report a patient with Noonan syndrome, hypertrophic cardiomyopathy, and complete occlusion of the proximal left coronary artery. (biomedsearch.com)
  • Pathologically, CTO is the result of atherosclerotic changes in coronary artery causing increased plaque burden leading to complete occlusion of the artery with time. (scirp.org)
  • The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of dogs subjected to temporary occlusions of a major coronary artery for 40 and 90 min. (jci.org)
  • Intravenous carbon black or thioflavin S (a fluorescent vital stain for endothelium) were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. (jci.org)
  • The phenomenon of "coronary steal," i.e., the shunting of blood from ischemic to normally perfused areas of myocardium, has been described as an effect of the administration of several vasodilating agents. (ahajournals.org)
  • The results indicate that while the coronary arterial flow to the normal myocardium fell from 90.6 +/- 4.3 to 77.7 +/- 3.2 ml/min/100 g (P less than 0.01), the collateral blood flow to the ischemic area increased from 21.4 +/- 3.5 to 41.0 +/- 4.2 ml/min/100 g (P less than 0.01), and thereby reduced acute myocardial ischemic injury. (ahajournals.org)
  • This study is structured to evaluate the feasibility and safety of autologous AC133+ bone marrow-derived stem cell via intra-coronary injection into documented ischemic but viable myocardial zones via established collateral vessels. (clinicaltrials.gov)
  • In conclusion, the K ATP channel blocker HMR 1883, which had no effect on hemodynamics and ECG under baseline conditions, reduced the extent of ischemic ECG changes and sudden death due to ventricular fibrillation during coronary occlusion. (aspetjournals.org)
  • Distension of the ischemic region has been related to an increased incidence of spontaneous ventricular arrhythmias following coronary occlusion. (revespcardiol.org)
  • This study analyzed whether regional ischemic distension predicts increased ventricular fibrillation inducibility after coronary occlusion in swine. (revespcardiol.org)
  • Regional ischemic expansion predicts increased ventricular fibrillation inducibility following coronary occlusion. (revespcardiol.org)
  • 6 , 7 , 8 , 9 Since coronary occlusion rapidly increases the mechanical tension in the ischemic region and in the border zone, 10 , 11 , 12 it is not surprising that the potential influence of mechanical changes on the genesis of ischemic ventricular arrhythmias has attracted research attention. (revespcardiol.org)
  • However, when end-diastolic data from multiple beats during inferior vena caval occlusion were compared, control and ischemic end-diastolic pressure-volume relations displayed little or no difference. (elsevier.com)
  • Relationship between epicardial ST-segment elevation and myocardial ischemic damage after experimental coronary artery occlusion in dogs. (semanticscholar.org)
  • A CTO was defined as an occlusion of at least 3 months of duration based on a previous angiogram showing the occluded vessel or clinical data on previous coronary ischemic events potentially related to a coronary occlusion. (biomedcentral.com)
  • Approximately 15% - 20% of patients undergoing diagnostic catheterization had one or more chronically occluded coronary arteries. (scirp.org)
  • We report a case of two simultaneously occluded coronary arteries. (sch.ac.kr)
  • 4. It is concluded that peak aortic flow acceleration is a sensitive index of myocardial function during acute coronary occlusion in conscious primates and that peak carotid flow acceleration is an indirect measure of myocardial performance under the same conditions. (clinsci.org)
  • Acute coronary occlusion may cause a wide range of autonomic reactions as evidenced by changes in heart rate, blood pressure and heart rate variability (10-12) , but there are limited data on potential changes of human arterial baroreflex function during acute coronary occlusion. (onlinejacc.org)
  • Animal research indicates that both chronic myocardial infarction and acute coronary occlusion impair baroreflex modulation of heart rate. (onlinejacc.org)
  • The abrupt and persistent thrombotic occlusion of a major epicardial coronary artery or its large branches, usually within a discrete segment marked by ≥1 mural atherosclerotic plaques, has been established as the cause of the common myocardial infarction. (ahajournals.org)
  • In 16 open chest dogs, 15 and 30 min after occlusion of the left anterior descending coronary artery, epicardial electrograms were recorded and regional myocardial blood flow (RMBF) was measured with radiolabeled microspheres. (ahajournals.org)
  • The relationship between early and late epicardial electrocardiographic changes as well as those in regional myocardial blood flow (MBF) and the severity of myocardial damage was determined in 12 anesthetized dogs with left anterior descending coronary artery ligation. (semanticscholar.org)
  • CTO of an epicardial coronary artery is one of the leading challenging complex lesion type when percutaneous coronary intervention (PCI) is indicated. (clinmedjournals.org)
  • The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients. (dovepress.com)
  • Previous coronary angiography revealed the RCA originated from a high anterior takeoff and progressed in the downward direction-a very rare anomalous origin and a CTO which was characterized by absence of a stump just after a small acute marginal branch, in the mid portion of RCA ( Figure 1A ). (omicsonline.org)
  • He immediately received 325 mg of aspirin, two sublingual nitroglycerins, and was emergently transferred to the catheterization lab, where coronary angiography revealed an occlusion of the right coronary artery in its distal portion (Figure 1). (eplabdigest.com)
  • Coronary angiography revealed that the tip of Conquest Pro guidewire was still in the subintimal space (Figure 2). (clinmedjournals.org)
  • The transradial approach (TRA) for coronary angiography and interventions is increasingly utilized around the world. (radcliffecardiology.com)
  • At the repeat vascular study fifteen months after his first one, the angiogram showed that his coronary artery system was totally normal and there were no blockages anywhere in the coronary blood vessels. (healthy.net)
  • 2 The effects of RF ablation on coronary vessels has been studied previously in an animal model using young pigs. (eplabdigest.com)
  • Coronary arteries are the blood vessels that supply blood and oxygen to the heart. (uabmedicine.org)
  • The coronary CTO vessels in 35 patients (97.2%) were completely opened. (iospress.com)
  • Acute coronary syndrome with precordial ST segment elevation is usually related to left anterior descending artery occlusion, although isolated right ventricular infarction has been described as a cause of ST elevation in V1-V3 leads. (hindawi.com)
  • A 42-year-old male patient with history of hypertension, dyslipidemia, diabetes mellitus, and previous myocardial infarction (MI) presented to the emergency department with acute coronary syndrome. (hindawi.com)
  • High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. (dovepress.com)
  • The region supplied by the temporarily ligated coronary artery (RSCA) was demonstrated by postmortal perfusion of this vessel using the dye light green. (ahajournals.org)
  • With most of the SVG flow feeding the coronaries in diastole, the proximal segments of the coronaries would only see diastolic LV pressures during SVG perfusion and would most likely steal most of the SVG coronary flow. (ctsnet.org)
  • The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET. (elsevier.com)
  • Therefore, the aim was to describe the main coronary perfusion territories using CE-SSFP and T2-STIR cardiovascular magnetic resonance data in patients after acute ST-segment-elevation myocardial infarction. (lu.se)
  • Detailed regional data are presented for use in software algorithms as a priori information on the extent of MaR. Conclusions - For the first time, cardiovascular magnetic resonance has been used to show the main coronary perfusion territories using CE-SSFP and T2-STIR. (lu.se)
  • A discussion is given of the results following various coronary sinus occlusion procedures in which it is indicated that it is desirable to produce a partial or gradual occlusion in order to lower the mortality rate both of the initial procedure as well as of the subsequent sudden arterial occlusion. (rupress.org)
  • Electrical alternation in experimental coronary artery occlusion. (docphin.com)
  • Proximal left coronary artery occlusion in a 15-year-old boy with noonan syndrome and hypertrophic cardiomyopathy. (biomedsearch.com)
  • Acute vessel closure due to dissection is a known complication of percutaneous coronary intervention and can be challenging to treat, especially if guidewire position is lost. (bioportfolio.com)
  • Percutaneous coronary intervention was performed in the right coronary artery through right radial approach using Amplatz 1 (6 French) guiding catheter. (hindawi.com)
  • Radial artery access is increasingly becoming popular among interventional cardiologists for patients undergoing percutaneous coronary intervention(PCI)/ diagnostic angiography secondary to its low complications rates. (clinicaltrials.gov)
  • Radial artery occlusion is usually clinically quiescent and doesn't require any intervention secondary to dual blood supply of the arm. (clinicaltrials.gov)
  • This hybrid approach, the development of drug-eluting stents that provide durable results, and declining percutaneous coronary intervention (PCI) volumes have formed "the perfect storm" that has ignited newfound interest in CTO PCI. (onlinejacc.org)
  • Coronary intervention for an anomalous coronary artery is a technically challenging and extremely complicated procedure, especially in case of transradial approach for CTOs without a stump [ 4 , 5 ]. (omicsonline.org)
  • A 65-year-old man with new onset effort angina was referred to our institute to undergo coronary intervention. (omicsonline.org)
  • Today, qualifying patients can be treated with a minimally invasive procedure called a percutaneous coronary intervention (PCI). (uabmedicine.org)
  • however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a lack of randomized data. (ovid.com)
  • Background Primary percutaneous coronary intervention (PPCI) programmes vary in admission criteria from open referral to acceptance of electrocardiogram (ECG) protocol positive patients only. (bmj.com)
  • AbstractBackgroundMany patients undergo percutaneous coronary intervention (PCI) without the use of non-invasive stress testing prior to treatment. (medworm.com)
  • Use of intravascular ultrasound (IVUS) for stent optimization in complex percutaneous coronary intervention (PCI) was shown to improve acute 1 and long-term clinical outcomes. (invasivecardiology.com)
  • Thrombolysis or primary percutaneous coronary intervention or Intralipid Infusion? (oatext.com)
  • We sought to examine the impact of CTO percutaneous coronary intervention (PCI) on long-term clinical outcome in the real world. (researchsquare.com)
  • Brazilian reports on percutaneous coronary intervention in this scenario are scarce. (jotci.org)
  • Immediate percutaneous coronary intervention was performed and a transvenous temporary pacemaker and intra-aortic balloon counterpulsation catheter were inserted. (sch.ac.kr)
  • After successful percutaneous coronary intervention (PCI), the patient was discharged 8 days post intervention. (sch.ac.kr)
  • Afterwards, percutaneous coronary intervention (PCI) to CTO of RCA was planned. (clinmedjournals.org)
  • We present a case of a patient with previous inferior wall infarction and new acute ST elevation myocardial infarction (STEMI) due to proximal right coronary thrombotic occlusion resulting in right ventricular infarction with precordial ST elevation and sinus node dysfunction. (hindawi.com)
  • To test this hypothesis, we produced a 2-min left circumflex coronary artery (LCX) occlusion in unanesthetized mongrel dogs (n = 7) instrumented to measure left ventricular pressure (LVP), ventricular electrogram, and coronary blood flow (CBF) with and without various doses of cocaine (0.0, 0.5, 1, 2, and 4 mg/kg). (nih.gov)
  • Effects of acute coronary occlusion and previous ischaemic injury on left ventricular wall motion in humans. (bmj.com)
  • Thus resting abnormalities of left ventricular function in unstable angina are effectively dissociated from acute changes in coronary flow. (bmj.com)
  • In control animals, left anterior descending coronary artery occlusion lead to a prompt and significant depression of the S-T segment (−0.35 mV) and a prolongation of the Q-J time (+46 ms), the former reflecting heterogeneity in the plateau phase of the action potentials and the latter reflecting irregular impulse propagation and delayed ventricular activation. (aspetjournals.org)
  • 001). On average, 6.6 (0.5) stimulation protocols were completed and 5.4 (0.6) ventricular fibrillation episodes induced between 10 and 60min of coronary occlusion. (revespcardiol.org)
  • Thus, elevations in resting diastolic pressure-volume relations and apparent increase in chamber elastic stiffness during coronary occlusion in humans appear dominated by altered right ventricular or pericardial loading. (elsevier.com)
  • The value of warning arrhythmias in the prediction of ventricular fibrillation within one hour of coronary occlusion. (meta.org)
  • Coronary artery anomalies have been found in 1% of the general population who underwent diagnostic coronary angiography [ 3 ]. (omicsonline.org)
  • Interestingly, there were fibrotic components in the proximal and distal edges of the occlusions with softer, organizing thrombus in the middle of the CTO in the late group, suggesting that the major areas of difficulty are at the entrance and exit segments of the CTO with percutaneous recanalization. (biomedsearch.com)
  • Radial artery occlusion can be documented by an abnormal Barbeau's test , visible obstruction on two-dimensional ultrasound or absence of Doppler flow signal distal to the puncture site. (clinicaltrials.gov)
  • A similar subintimal crossing and crush technique of an in-stent restenotic lesion in the distal coronary artery has been reported by others, with continued patency documented on coronary angiography performed 9 months later. (invasivecardiology.com)
  • The blockage of a coronary artery from plaque (95-97% of all CAD cases). (cardiogod.com)
  • Catheterization at that time revealed anomalous right coronary artery originating from the left Valsalva sinus with moderate proximal obstruction and the patient received medical treatment. (hindawi.com)
  • b) proximal occlusion of anomalous right coronary artery (black arrow) originating in the left Valsalva sinus. (hindawi.com)
  • In this case, we describe a rare case of a CTO in the mid portion of an anomalous right coronary artery (RCA), that originated from a high anterior takeoff and progressed in the downward direction, where retrograde approach has been used to overcome the absence of antegrade guiding catheter support. (omicsonline.org)
  • Baseline biplane angiographic views of RCA CTO - Left and right coronary artery injections. (springer.com)
  • On this occasion, radiographic contrast has been injected via both the RCA and left coronary artery to reveal retrograde filling of RCA beyond the occlusion. (springer.com)
  • He underwent heart catheterization and was found to have his left main anterior descending coronary artery completely blocked. (healthy.net)
  • Furthermore, Poisson regression showed that for each 10-mm increase in distance from the ostium, the risk of an acute coronary occlusion was significantly decreased by 13% in the right coronary artery, 30% in the left anterior descending artery, and 26% in the left circumflex artery. (ahajournals.org)
  • Right coronary artery had its anomalous origin close to the left coronary sinus and was occluded in the proximal segment (Figure 3 ). (hindawi.com)
  • Sudden occlusion of the left anterior descending branch approximately 2 cm. below the ostium of the left circumflex coronary artery in the dog's heart produces a mortality rate of approximately 50 per cent. (rupress.org)
  • Following coronary sinus obturation such secondary sudden occlusion of the left anterior descending branch is followed either by no infarction or by a reduction in the size of the infarct. (rupress.org)
  • On the other hand, sudden and complete coronary sinus obturation by itself is associated with a high operative mortality and apparently does not affect the mortality rate following subsequent sudden left anterior descending branch occlusion. (rupress.org)
  • Furthermore, its experimental production in dogs appears to lower the mortality rate following subsequent sudden occlusion of the left anterior descending branch and to diminish the extent of the infarction. (rupress.org)
  • Although no experiments employing sudden left anterior descending coronary branch occlusion were carried out sooner than 1 week, there is available anatomic evidence that within possibly 24 hours after coronary sinus occlusion a dilatation of the vascular bed occurs. (rupress.org)
  • In subsequent experiments attempts will be made to determine whether this early vascular dilatation is adequate to compensate for subsequent sudden left anterior descending branch occlusion. (rupress.org)
  • Reflex increases in heart rate which occurred during 1-minute occlusions of the left circumflex coronary artery were studied in conscious dogs. (ahajournals.org)
  • The results indicated that occlusion produced tachycardia (latency to onset 8.5 seconds) preceded by a rise in left atrial pressure (7.2 seconds) and followed by a small fall in arterial pressure (19.5 seconds). (ahajournals.org)
  • 2. The response to occlusion for 60 s of the circumflex branch or the anterior descending branch of the left coronary artery was investigated. (clinsci.org)
  • Regarding Dr. Baslaim's comments, my main concern with bypassing the left and right coronary systems and tacking the valve in place would be the unpredictable steal from the proximal native coronaries if the prosthesis migrated further up and the coronary ostia were clearly below the valve. (ctsnet.org)
  • We investigated the effect of HMR 1883 on sudden cardiac arrhythmic death and electrocardiography (ECG) changes induced by 20 min of left anterior descending coronary artery occlusion in pentobarbital-anesthetized pigs. (aspetjournals.org)
  • In 18 anesthetized, open-chest pigs, the left anterior descending coronary artery was ligated for 60min. (revespcardiol.org)
  • We present a case of a left circumflex (LCX) coronary artery CTO due to ISR of a double layer of stent, both of which were under-deployed, utilizing a novel cutting balloon (Wolverine Cutting Balloon, Boston Scientific) after oversized noncompliant balloon inflation and both laser and rotational atherectomy failed to provide adequate lumen gain. (cathlabdigest.com)
  • We seated a 7 Fr 90 cm Judkins right (JR) 4 guide in the right coronary artery (RCA) and an 8 Fr 100 cm extra backup (EBU) 4.0 guide in the left main coronary artery (LMCA), and performed dual angiography (Figure 1). (cathlabdigest.com)
  • We present the management of an occluded left coronary artery after a self-expanding TAVR, and review the incidence, prevention, and management of this complication. (readbyqxmd.com)
  • Mean extent of MaR using CE-SSFP was 44±10% for left anterior descending artery, 31±7% for right coronary artery, and 30±9% for left circumflex artery. (lu.se)
  • Using T2-STIR, MaR was 44±9% for left anterior descending artery, 30±8% for right coronary artery, and 30±12% for left circumflex artery. (lu.se)
  • MaR was visualized in polar plots, and expected overlap was found between right coronary artery and left circumflex artery. (lu.se)
  • 1 It is widely held that the proximate cause of sudden coronary thrombosis is erosion or frank rupture of an underlying plaque, leading to a pathological cascade of platelet adherence and thrombus formation on the exposed plaque surface. (ahajournals.org)
  • In 01/2017, she had recurrence of her anginal equivalent, and underwent coronary and graft angiography, which showed recurrent ISR of her LCX Promus stents. (cathlabdigest.com)
  • She then underwent repeat coronary and graft angiography, which showed a CTO of her proximal LCX segment where brachytherapy had previously been administered. (cathlabdigest.com)
  • The fact that the occlusion occurred more often with a patent graft than with a closed graft suggests a hemodynamic component in its pathogenesis. (elsevier.com)
  • 7 , 8 The diagnosis of ACS may need to be confirmed by coronary angiogram, but some studies have used clinical diagnosis of ACS. (dovepress.com)
  • The role of the ECG in diagnosis, risk estimation, and catheterization laboratory activation in patients with acute coronary syndromes: a consensus document. (semanticscholar.org)
  • The objective of this research study is to test the accuracy of preexisting criteria versus expert interpretation for the diagnosis of acute coronary occlusion (major heart attack due to a completely blocked blood vessel). (clinicaltrialslocator.com)