An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The circulation of blood through the CORONARY VESSELS of the HEART.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Narrowing or constriction of a coronary artery.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Spasm of the large- or medium-sized coronary arteries.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Elements of limited time intervals, contributing to particular results or situations.
Pathologic deposition of calcium salts in tissues.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Pressure, burning, or numbness in the chest.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The hollow, muscular organ that maintains the circulation of the blood.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Drugs used to cause dilation of the blood vessels.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Radiography of the heart and great vessels after injection of a contrast medium.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The return of a sign, symptom, or disease after a remission.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Substances used to lower plasma CHOLESTEROL levels.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A characteristic symptom complex.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Research techniques that focus on study designs and data gathering methods in human and animal populations.
Inhaling and exhaling the smoke of burning TOBACCO.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The transference of a heart from one human or animal to another.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
7-carbon saturated monocarboxylic acids.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Disease having a short and relatively severe course.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Contractile activity of the MYOCARDIUM.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Radiography of blood vessels after injection of a contrast medium.
Obstruction of flow in biological or prosthetic vascular grafts.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The prevention of recurrences or exacerbations of a disease or complications of its therapy.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Formation and development of a thrombus or blood clot in the blood vessel.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Lesions formed within the walls of ARTERIES.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Conditions with excess LIPIDS in the blood.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Therapy with two or more separate preparations given for a combined effect.
Unstable isotopes of rubidium that decay or disintegrate emitting radiation. Rb atoms with atomic weights 79-84, and 86-95 are radioactive rubidium isotopes.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Individuals whose ancestral origins are in the continent of Europe.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
Motion pictures of the passage of contrast medium through blood vessels.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
The main trunk of the systemic arteries.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.

Anti-heart autoantibodies in ischaemic heart disease patients. (1/12062)

One hundred and ninety-nine ischaemic heart disease (IHD) patients were studied with regard to the prevalence of anti-heart autoantibodies (AHA). The incidence of AHA in IHD patients was 1%: one out of 102 patients who suffered acute myocardial infarction (AMI), one out of seventy-two patients who suffered from acute coronary insufficiency (ACI), and none out of twenty-five patients with other signs and symptoms of IHD, had AHA in their sera. An additional 2% of patients who suffered from AMI developed detectable antibody levels during a follow-up period of 15 days. In comparison,, 53% of patients (eight out of fifteen) who underwent heart surgery and who had no AHA prior to operation, developed these antibodies in their sera during 1-2 weeks following operation.  (+info)

Comparative total mortality in 25 years in Italian and Greek middle aged rural men. (2/12062)

STUDY OBJECTIVE: Mortality over 25 years has been low in the Italian and very low in the Greek cohorts of the Seven Countries Study; factors responsible for this particularity were studied in detail. PARTICIPANTS AND SETTINGS: 1712 Italian and 1215 Greek men, aged 40-59 years, cohorts of the Seven Countries Study, representing over 95% of the populations in designated rural areas. DESIGN: Entry (1960-61) data included age, systolic blood pressure (SBP), smoking habits, total serum cholesterol, body mass index (BMI), arm circumference, vital capacity (VC), and forced expiratory volume in 3/4 seconds (FEV); the same data were obtained 10 years later. Multivariate Cox analysis was performed with all causes death in 25 years as end point. MAIN RESULTS: Italian men had higher entry levels of SBP, arm circumference, BMI, and VC; Greek men had higher cholesterol levels, smoking habits, and FEV. Mortality of Italian men was higher throughout; at 25 years cumulative mortality was 48.3% and 35.3% respectively. Coronary heart disease and stroke mortality increased fivefold in Italy and 10-fold in Greece between years 10 and 25. The only risk factor with a significantly higher contribution to mortality in Italian men was cholesterol. However, differences in entry SBP (higher in Italy) and FEV (higher in Greece) accounted for, according to the Lee method, 75% of the differential mortality between the two populations. At 10 years increases in SBP, cholesterol, BMI, and decreases in smoking habits, VC, FEV, and arm circumference had occurred (deltas). SBP increased more and FEV and VC decreased more in Italy than in Greece. Deltas, fed stepwise in the original model for the prediction of 10 to 25 years mortality, were significant for SBP, smoking, arm circumference, and VC in Greece, and for SBP and VC in Italy. CONCLUSION: Higher mortality in Italian men is related to stronger positive effects of entry SBP and weaker negative (protective) effects of FEV; in addition 10 year increases in SBP are higher and 10 year decreases in FEV are larger in Italy. Unaccounted factors, however, related to, for example, differences in the diet, may also have contributed to the differential mortality of these two Mediterranean populations.  (+info)

Is hospital care involved in inequalities in coronary heart disease mortality? Results from the French WHO-MONICA Project in men aged 30-64. (3/12062)

OBJECTIVES: The goal of the study was to assess whether possible disparities in coronary heart disease (CHD) management between occupational categories (OC) in men might be observed and contribute to the increasing inequalities in CHD morbidity and mortality reported in France. METHODS: The data from the three registers of the French MONICA Collaborative Centres (MCC-Lille, MCC-Strasbourg, and MCC-Toulouse) were analysed during two period: 1985-87 and 1989-91. Acute myocardial infarctions and coronary deaths concerning men, aged 30-64 years, were included. Non-professionally active and retired men were excluded. Results were adjusted for age and MCC, using a logistic regression analysis. RESULTS: 605 and 695 events were analysed for 1985-87 and 1989-91, respectively. Out of hospital cardiac arrests, with or without cardiac resuscitation, and 28 day case fatality rates were lower among upper executives in both periods. A coronarography before the acute event had been performed more frequently in men of this category and the proportion of events that could be hospitalised was higher among them. In both periods, the management of acute myocardial infarctions in hospital and prescriptions on discharge were similar among occupational categories. CONCLUSIONS: For patients who could be admitted to hospital, the management was found to be similar among OCs, as was the 28 day case fatality rate among the hospitalised patients. In contrast, lower prognosis and higher probability of being hospitalised after the event among some categories suggest that pre-hospital care and the patient's conditions before the event are the primary factors involved.  (+info)

Short stature and cardiovascular disease among men and women from two southeastern New England communities. (4/12062)

BACKGROUND: Short stature has been associated with an increased risk of coronary heart disease (CHD), although the reason for the association remains unclear. Data on the relation between stature and stroke is more limited. We examined the association between stature and CHD as well as between stature and stroke in men and women from two communities in southeastern New England. METHODS: Coronary heart disease and stroke events were abstracted from medical records between January 1980 and December 1991. An epidemiological diagnostic algorithm developed to measure CHD was used in the present analysis. Unadjusted relative risks (RR) and RR adjusted for age, smoking status, obesity, high-density lipoprotein (HDL) cholesterol <0.91 mmol/l, total cholesterol >6.21 mmol/l, hypertension, diabetes, education, and being foreign born were computed by gender-specific height categories separately for men (n = 2826) and women (n = 3741). RESULTS: A graded inverse association between stature and risk of CHD was observed among men which persisted after adjustment for confounders. Men >69.75 inches had an 83% lower risk of CHD compared with men < or = 65 inches. In addition, the tallest men had a 67% decreased risk of stroke compared with the shortest men. No significant relation between stature and CHD or stroke was observed among women. CONCLUSIONS: These data support the hypothesis that stature is inversely related to both risk of CHD and stroke at least among men. Factors which might explain this association remain to be determined.  (+info)

Natural sporting ability and predisposition to cardiovascular disorders. (5/12062)

We tested the hypothesis that people with a natural ability in 'power sports' (a presumed marker for predominance of type 2, glycolytic muscle fibres) might have increased risks of coronary heart disease (CHD) compared to those with a natural ability in 'endurance sports' (as a marker for predominance of type 1, oxidative muscle fibres). We examined subsequent cardiovascular disorders retrospectively in 231 male former soldiers, aged 34-87 years, who had undergone a course in physical training in the Army School of Physical Training, Aldershot, UK, who assessed themselves as having natural ability in either power (n = 107) or endurance (n = 124) sports. The proportion with CHD, defined as angina and/or coronary angioplasty and/or coronary artery bypass graft and/or heart attack was 18.7% in the 'power group' vs. 9.7% in the 'endurance group' (difference: chi 2 = 3.9, p = 0.05). The proportions with CHD and/or risk factors rose to 39.3% in the 'power group' vs. 25.8% in the 'endurance group' (difference: chi 2 = 4.8, p = 0.03). Under logistic regression analysis, compared to the 'endurance group', the 'power group' had 2.2 (95% CI: 1.00-4.63) the risk of developing CHD, and 1.86 (95% confidence interval: 1.06 to 3.25) the risk of developing CHD and/or risk factors. Men with a natural ability in 'power sports' are at increased risk of developing cardiovascular disorders, compared to men with a natural ability in 'endurance sports'. A predominance of type 2, glycolytic muscle fibres, presumably of genetic origin, may predispose to cardiovascular disorders.  (+info)

The PRIME study: classical risk factors do not explain the severalfold differences in risk of coronary heart disease between France and Northern Ireland. Prospective Epidemiological Study of Myocardial Infarction. (6/12062)

We are studying the contribution of risk and genetic factors, and their interaction, to the development of ischaemic heart disease (IHD) and other cardiovascular endpoints. The study is prospective, based in three centres in the south, east and north of France and in Northern Ireland. A total of 10,592 men aged 50-59 years were recruited from 1991 to 1993, and examined for evidence of IHD at baseline. Subjects are followed annually by questionnaire. Clinical information is validated from hospital and GP records. Demographic characteristics were similar in all four centres. Body mass index was highest in Strasbourg (mean 27.4 kg/m2 vs. 26.3 kg/m2 in Toulouse and Belfast), but total cholesterol, triglyceride and fibrinogen were highest in Belfast. In Belfast, 6.1% reported having had a coronary angiogram, compared to 3.0% in Toulouse. Conversely, 13.8% in Toulouse reported taking lipid-lowering drugs vs. 1.6% in Belfast. As predicted, a history of myocardial infarction (MI) was highest in Belfast (6.1%) and lowest in Toulouse (1.2%). Some 7.1% of Belfast men reported a medical diagnosis of angina vs. 1.5% in Toulouse. Subjects showing evidence of pre-existing IHD will be studied prospectively but treated in the analysis as an additional variable. These results provide a measure of reassurance that these cohorts are representative of the communities from which they are drawn and provide a reliable baseline for prospective evaluation and cross-sectional comparisons. The levels of the classical risk factors found in this study, particularly when examined in combination, as multiple logistic functions based on previous British studies, are very similar between centres and cannot explain the large differences in the incidence of IHD which exist. Additional risk factors may help explain, at least in part, the major differences in incidence of IHD between these study centres.  (+info)

Chlamydia pneumoniae and atherosclerosis. (7/12062)

OBJECTIVE: To review the literature for evidence that chronic infection with Chlamydia pneumoniae is associated with atherosclerosis and acute coronary syndromes. DATA SOURCES: MEDLINE and Institute of Science and Information bibliographic databases were searched at the end of September 1998. Indexing terms used were chlamydi*, heart, coronary, and atherosclerosis. Serological and pathological studies published as papers in any language since 1988 or abstracts since 1997 were selected. DATA EXTRACTION: It was assumed that chronic C pneumoniae infection is characterised by the presence of both specific IgG and IgA, and serological studies were examined for associations that fulfilled these criteria. Pathological studies were also reviewed for evidence that the presence of C pneumoniae in diseased vessels is associated with the severity and extent of atherosclerosis. DATA SYNTHESIS: The majority of serological studies have shown an association between C pneumoniae and atherosclerosis. However, the number of cases in studies that have reported a positive association when using strict criteria for chronic infection is similar to the number of cases in studies which found no association. Nevertheless, the organism is widely found in atherosclerotic vessels, although it may not be at all diseased sites and is not confined to the most severe lesions. Rabbit models and preliminary antibiotic trials suggest that the organism might exacerbate atherosclerosis. CONCLUSION: More evidence is required before C pneumoniae can be accepted as playing a role in atherosclerosis. Although use of antibiotics in routine practice is not justified, large scale trials in progress will help to elucidate the role of C pneumoniae.  (+info)

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (8/12062)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

TY - JOUR. T1 - Explaining the decline in coronary heart disease mortality rates in Japan. T2 - Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. AU - Ogata, Soshiro. AU - Nishimura, Kunihiro. AU - Guzman-Castillo, Maria. AU - Sumita, Yoko. AU - Nakai, Michikazu. AU - Nakao, Yoko M.. AU - Nishi, Nobuo. AU - Noguchi, Teruo. AU - Sekikawa, Akira. AU - Saito, Yoshihiko. AU - Watanabe, Taeko. AU - Kobayashi, Yasuki. AU - Okamura, Tomonori. AU - Ogawa, Hisao. AU - Yasuda, Satoshi. AU - Miyamoto, Yoshihiro. AU - Capewell, Simon. AU - OFlaherty, Martin. PY - 2019/9/15. Y1 - 2019/9/15. N2 - Background: We aimed to quantify contributions of changes in risks and uptake of evidence-based treatment to coronary heart disease (CHD) mortality trends in Japan between 1980 and 2012. Methods: We conducted a modelling study for the general population of Japan aged 35 to 84 years using the validated IMPACT model incorporating data sources like Vital Statistics. The main ...
TY - JOUR. T1 - Progression of coronary calcium and incident coronary heart disease events. T2 - MESA (Multi-Ethnic Study of Atherosclerosis). AU - Budoff, Matthew J.. AU - Young, Rebekah. AU - Lopez, Victor A.. AU - A. Kronmal, Richard. AU - Nasir, Khurram. AU - Blumenthal, Roger S.. AU - Detrano, Robert C.. AU - Bild, Diane E.. AU - Guerci, Alan D.. AU - Liu, Kiang. AU - Shea, Steven. AU - Szklo, Moyses. AU - Post, Wendy. AU - Lima, Joao. AU - Bertoni, Alain. AU - Wong, Nathan D.. PY - 2013/3/26. Y1 - 2013/3/26. N2 - Objectives: The study examined whether progression of coronary artery calcium (CAC) is a predictor of future coronary heart disease (CHD) events. Background: CAC predicts CHD events and serial measurement of CAC has been proposed to evaluate atherosclerosis progression. Methods: We studied 6,778 persons (52.8% female) aged 45 to 84 years from the MESA (Multi-Ethnic Study of Atherosclerosis) study. A total of 5,682 persons had baseline and follow-up CAC scans approximately 2.5 ± ...
Stressful Life Events and Coronary Heart Disease Patients, 978-613-8-23434-0, Psychological factors play a very important role in the existence and formation of Heart diseases, especially Coronary Heart Disease (CHD). Nowadays, heart diseases especially CHD which its clinical spectrum varies from silence ischemia to stable angina, unstable angina, myocardial infection and sudden heart death is one of the three main causes of death in the industrial countries besides cancer and brain stroke. Fifty million people die annually around the world; 12 million of them die because of cardiovascular diseases.Stress can affect persons health through behavioral and physiologic changes. Stress can also lead to heart diseases through psychological changes. It seems that stress has direct effects on coronary arteries and heart muscles. Nontraditional risk factors, such as psychological traits, have been increasingly recognized as important contributors to the genesis and outcomes of coronary artery disease. Mental
The Stanford Five-City Project was initiated in 1978 to evaluate the effects of community-wide health education on coronary heart disease risk factors in two control San Luis Obispo and Modesto and two treatment Monterey and Salinas cities. This paper examines sex differences in the prevalence of smoking, hypercholesterolemia, and hypertension...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
Abstract: Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation, has been widely used for treatment of coronary heart disease (CHD) in China. However, the active constituents of XKS and their interactions with targets remain unclear. In this study, we assessed two docking programs, LibDock and AutoDock, by calculating the root-mean-square deviation (RMSD) of X-ray structure reproduction and the enrichment factor (EF) in virtual screening; both proved to be practical in our protein-ligand complex systems. Moreover, the combined use of the two programs yielded better EFs for each target. We therefore used a combination of the two programs to investigate the interactions of the 51 chemical constituents identified from XKS with five CHD targets, namely peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2), and thrombin. The docking results suggest that pueroside A, pueroside ...
heartdiseasehotline - informative website on coronary heart disease, congential heart disease, heart disease women, rheumatic heart disease, heart disease prevention, heart disease risk (archive ID #3) - Read it at RSS2.com
heartdiseasehotline - informative website on coronary heart disease, congential heart disease, heart disease women, rheumatic heart disease, heart disease prevention, heart disease risk - Read it at RSS2.com
Coronary heart disease currently affects more than 7 million Americans, making it the most common form of heart disease. Men initially have a greater risk for developing coronary heart disease than women do. Once a woman reaches menopause however, her risk for heart disease eventually equals or surpasses that of a man. Experts believe this may be due in part to a decrease in the production of estrogen, a female sex hormone that appears to offer some protection against heart disease.. Coronary heart disease remains the number one cause of death for both women and men in the US, accounting for more than 500,000 deaths from heart attacks each year. Experts agree that many of these deaths can be prevented by changes in lifestyle, which when implemented, can directly reduce your chances for developing coronary heart disease.. Risk factors for coronary heart disease are circumstances or conditions that increase the likelihood of your developing this disease. Risk factors are generally divided into two ...
Heart disease is the number one killer in the United States (American Heart Association, 2005). The purpose of this study was to demonstrate the results of a twelve-week exercise program on coronary heart disease risk factors in full-time hospital employees. Methods: The participants were given cardiovascular, weight training, and flexibility recommendations to follow during a twelve-week period. The main heart disease risk factors measured before and after the completion of the exercise program were blood pressure, total cholesterol, HDL-cholesterol, and body mass index. The information was put into the Framingham Heart Score to estimate the participants 10-year risk of developing heart disease. Other factors measured to show the benefits of exercise included resting heart rate, weight, body fat percentage, waist and hip ratio, maximal oxygen uptake (VO2), and flexibility. Results: There were no significant results from any measurements taken.
BACKGROUND Adult height has been inversely associated with coronary heart disease risk in several studies. The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study. METHODS All men aged 45-59 years living in the town of Caerphilly, South Wales were approached, and 2512 (89%) responded and underwent a detailed examination, which included measurement of height and sitting height (from which an estimate of leg length was derived). Participants were followed up through repeat examinations and the cumulative incidence of coronary heart disease-both fatal and non-fatal-over a 15 year follow up period is the end point in this report. RESULTS Cross sectional associations between cardiovascular risk factors and components of stature (total height, leg length and trunk length) demonstrated that factors related to the insulin resistance ...
Results:. Study 1: 10-year cardiovascular mortality was significantly and linearly associated with glycemic control (fasting blood glucose and glycated hemoglobin A1 levels) independently of the mode of treatment. A high fasting blood glucose level significantly predicted cardiovascular mortality in multiple logistic regression analysis independently of other risk factors. Study 2: Glycated hemoglobin A1c was the most important single risk factor associated with coronary heart disease death or all coronary heart disease events. In multiple logistic regression analysis, glycated hemoglobin A1c was significantly associated with coronary heart disease death after adjustment for other cardiovascular risk factors. ...
Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk reduction for sudden cardiac death among postmenopausal women, according to an analysis published in the Journal of Women’s Health.“Our understanding of the etiology and risk factors for fatal coronary heart disease and sudden cardiac death, particularly among
TY - JOUR. T1 - Ten-year predicted coronary heart disease risk in HIV-infected men and women. AU - Kaplan, Robert C.. AU - Kingsley, Lawrence A.. AU - Sharrett, A. Richey. AU - Li, Xiuhong. AU - Lazar, Jason. AU - Tien, Phyllis C.. AU - Mack, Wendy J.. AU - Cohen, Mardge H.. AU - Jacobson, Lisa. AU - Gange, Stephen J.. PY - 2007/10/22. Y1 - 2007/10/22. N2 - Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among ...
Results. Both middle-aged and elderly men with T wave amplitudes ≥0.15 mV had a lower risk of myocardial infarction, coronary heart disease death and sudden death than men with T wave amplitudes 0.05 to 0.15 mV. The adjusted relative risk of coronary heart disease death was 0.5 (95% confidence interval [CI] 0.2 to 1.0); in men with T wave amplitude ≤0.05 mV, relative risk was 2.0 (95% CI 1.3 to 3.1). Slight ST segment elevation was also associated with decreased risk: relative risk 0.5 (95% CI 0.3 to 1.0) compared with the isoelectric ST segment level. In men with ST segment depression, relative risk was 2.2 (95% CI 1.4 to 3.4). The associations of T wave amplitude and ST segment level were independent of each other. ...
I dont know what to make of this new study. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001177 Background...
I dont like Mondays---day of the week of coronary heart disease deaths in Scotland: study of routinely collected data Academic Article ...
In a prospective study of over 17 000 civil servants followed up for 25 years, there was an inverse association between SES and CHD mortality in participants with and without prevalent CHD at baseline.. The inverse social gradient in CHD mortality could be a result of increased incidence (aetiology), case fatality (prognosis) or both among those of lower SES. Case fatality includes both survival of an acute event, such as myocardial infarction, and prognosis in chronic manifestations of CHD, such as angina. We studied the latter-established CHD in a working population- and found a significant effect of SES on CHD mortality among those with prevalent CHD defined by symptomatic status. When prevalent CHD was defined by Q, ST or T abnormality in the absence of symptoms, the SES effect was similar but the confidence intervals spanned unity. Participants with both symptoms and ECG abnormality were at very high risk (relative to those without symptoms or any ECG abnormality) and in this group there ...
TY - JOUR. T1 - Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. AU - Chambless, Lloyd E.. AU - Folsom, Aaron R.. AU - Sharrett, A. Richey. AU - Sorlie, Paul. AU - Couper, David. AU - Szklo, Moyses. AU - Nieto, F. Javier. PY - 2003/9/1. Y1 - 2003/9/1. N2 - Risk prediction functions for incident coronary heart disease (CHD) were estimated using data from the Atherosclerosis Risk in Communities (ARIC) Study, a prospective study of CHD in 15,792 persons recruited in 1987-1989 from four U.S. communities, with follow-up through 1998. Predictivity of which individuals had incident CHD was assessed by increase in area under ROC curves resulting from adding nontraditional risk factors and markers of subclinical disease to a basic model containing only traditional risk factors. We also assessed the increase in population attributable risk. The additional factors were body mass index; waist-hip ratio; sport activity index; forced expiratory volume; plasma ...
Doug Manuel, MD, MSc, William M. Flanagan, BM, Meltem Tuna, PhD, Anya Okhmatovskaia, PhD, Philippe Finès, PhD; Carol Bennett, MSc. Coronary heart disease risk factors in Canada: a Microsimulation predictive model. Simulated Technology for Applied Research (STAR). Slideshow 3725048 by cicero
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TY - JOUR. T1 - Consensus on. T2 - Screening and therapy of coronary heart disease in diabetic patients. AU - Rivellese, A. A.. AU - Piatti, P. M.. PY - 2011/10. Y1 - 2011/10. N2 - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason the main Italian scientific societies dealing with diabetes and cardiovascular diseases have tried to finalize a document providing shared recommendations based on the available evidence on: 1) how and who to screen for coronary heart disease, 2) methodologies for the characterization of existing coronary heart disease 3) evaluation of the optimal treatment of cardiovascular risk factors and 4) appropriate revascularization procedures. For each of these points, the levels of evidence and strength of recommendations used in the Italian Standard of Care were adopted.. AB - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason ...
TY - JOUR. T1 - Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke. T2 - A pooled analysis of 97 prospective cohorts with 1·8 million participants. AU - The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects). AU - Lu, Yuan. AU - Hajifathalian, Kaveh. AU - Ezzati, Majid. AU - Woodward, Mark. AU - Rimm, Eric B.. AU - Danaei, Goodarz. AU - Selmer, Randi. AU - Strand, Bjorn H.. AU - Dobson, A.. AU - Hozawa, A.. AU - Nozaki, A.. AU - Okayama, Akira. AU - Rodgers, A.. AU - Tamakoshi, A.. AU - Zhou, B. F.. AU - Zhou, B.. AU - Yao, C. H.. AU - Jiang, C. Q.. AU - Gu, D. F.. AU - Heng, D.. AU - Giles, Graham G.. AU - Shan, G. L.. AU - Whitlock, G.. AU - Arima, H.. AU - Kim, H. C.. AU - Christensen, H.. AU - Horibe, H.. AU - Maegawa, H.. AU - Tanaka, H.. AU - Ueshima, Hirotsugu. AU - Zhang, H. Y.. AU - Kim, I. S.. AU - Suh, I.. AU - Fuh, J. L.. AU - Lee, J.. AU - Woo, Jean. AU - Xie, J. ...
Objectives. We attempted to determine whether elevated levels of the classic coronary heart disease risk factors are associated with increased coronary risk and all-cause mortality among elderly men with and without coronary heart disease at baseline. Methods. The classic coronary risk factor levels and risk of coronary events and total...
BackgroundCurrent guidelines do not recommend routine cardiac stress testing in patients with stable coronary heart disease (CHD) unless they report symptoms of
TY - JOUR. T1 - More on coronary heart disease. T2 - The dietary sense and nonsense [3]. AU - Holmqvist, O. H.. AU - Bassler, T. J.. AU - Enig, M. G.. AU - Stone, N. J.. PY - 1994/1/1. Y1 - 1994/1/1. UR - http://www.scopus.com/inward/record.url?scp=1642500224&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=1642500224&partnerID=8YFLogxK. U2 - 10.1056/NEJM199409013310913. DO - 10.1056/NEJM199409013310913. M3 - Letter. C2 - 8047096. AN - SCOPUS:1642500224. VL - 331. SP - 614. EP - 616. JO - New England Journal of Medicine. JF - New England Journal of Medicine. SN - 0028-4793. IS - 9. ER - ...
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The Treating to New Targets (TNT) trial compared atorvastatin 80 mg (aiming at reducing LDL cholesterol | or = 75 mg/dl) and atorvastatin 10 mg (LDL | or = 100 mg/dl as target) in 10,001 patients with stable coronary heart disease followed up for 5 years. A reduction of major cardiovascular events of 22% was observed in the atorvastatin 80 mg group as compared to the atorvastatin 10 mg group (hazard ratio: 0.78; 95 % interval of confidence: 0.69-0.89; p | 0.001). Such clinical efficacy was obtained while a good drug safety profile was maintained. Total mortality was not significantly different between the two groups. However, and remarkably, cardiovascular death was not the first cause of death anymore in this atorvastatin-treated population. The results of TNT in patients with stable coronary heart disease thus confirm the results of PROVE-IT in patients with acute coronary syndrome. These two randomised controlled trials should encourage considering a LDL cholesterol level of 75 mg/dl (rather than
A high body mass index (BMI) is associated with an increased risk of mortality from coronary heart disease (CHD); however, a low BMI may also be associated with an increased mortality risk. There is limited information on the relation of incident CHD risk across a wide range of BMI, particularly in women. We examined the relation between BMI and incident CHD overall and across different risk factors of the disease in the Million Women Study. 1.2 million women (mean age = 56 years) participants without heart disease, stroke, or cancer (except non-melanoma skin cancer) at baseline (1996 to 2001) were followed prospectively for 9 years on average. Adjusted relative risks and 20-year cumulative incidence from age 55 to 74 years were calculated for CHD using Cox regression. After excluding the first 4 years of follow-up, we found that 32,465 women had a first coronary event (hospitalization or death) during follow-up. The adjusted relative risk for incident CHD per 5 kg/m2 increase in BMI was 1.23 (95%
Lifestyle and risk factor results clearly demonstrate a challenging gap between what is recommended in scientific guidelines and what is achieved in daily practice in high risk individuals in primary prevention of CVD.. Primary prevention of heart disease needs a comprehensive, multidisciplinary approach involving the high-risk population, their GPs and other health professionals, a health insurance system dedicated to prevention and all this complemented by a population strategy involving the community at large.. The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. Guidelines on this important topic have been developed and updated at regular intervals over the last 13 years, most recently in 2007. The implementation of these guidelines is facilitated by the Joint European Prevention Committee and the new European Association for Cardiovascular Prevention and Rehabilitation ...
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
DALLAS, TX -The American Heart Association (AHA) and Verily, (formerly Google Life Sciences) announced today that AstraZeneca (AZ) has joined them in a bold new approach to find a cure for coronary heart disease and improve cardiovascular health. With a commitment of $75 million dollars over at least a five year period, the three organizations have initiated the single largest research project funding one leader and team in the fight to cure coronary heart disease. The application period for this new research enterprise officially opens today at 5:00 PM ET at: www.onebraveidea.com. The three organizations have joined forces to find one brave idea from a visionary leader. This person and their team will be awarded the opportunity and challenge to make a difference for the millions of people directly affected by coronary heart disease. Their goal: prevent or reverse coronary heart disease and its consequences, therein restoring cardiovascular health. Launched as One Brave Idea™, this research ...
Treating depression in those with coronary heart disease: CODIACS Vanguard Randomized Controlled Trial. NEW YORK - Depressive symptoms after heart disease are associated with a markedly increased risk of death or another heart attack. However, less has been known about whether treating heart attack survivors for depressive symptoms could relieve these symptoms, be cost-effective, and ultimately, reduce medical risk? Columbia University Medical Centers Karina W. Davidson, PhD and her research team now report a patient-centered approach that answers these questions in the affirmative.. With a grant from the National Institutes of Healths National Heart, Lung, and Blood Institute (NHLBI), Dr. Karina Davidson, director of the Center for Behavioral Cardiovascular Health at CUMC, and her team completed a randomized controlled trial with 150 patients with elevated depressive symptoms two to six months after hospitalization for heart disease. Patients were recruited from seven centers across the ...
TY - JOUR. T1 - Can non-medical factors contribute to disparities in coronary heart disease treatments?. AU - Barnhart, Janice M.. AU - Cohen, Oshra. AU - Wright, Natania. AU - Wylie-Rosett, Judith. PY - 2006/8/1. Y1 - 2006/8/1. N2 - Racial/ethnic and sex disparities in coronary heart disease treatment exist. We previously reported that physicians perceive non-clinical variables, such as a patients desire for a second opinion, as affecting revascularization decisions. The results of that study are further examined here, using factor analysis to identify significant interrelationships among the non-clinical variables, which could contribute to disparities in coronary revascularization (i.e., percutaneous transluminal coronary angioplasty [PTCA] or coronary artery bypass graft [CABG]). Five content themes emerged using factor analysis; these are related to the patients socioeconomic/lifestyle status, treatment preference, physician interaction, health-assertiveness, and aggressiveness. For the ...
Coronary heart disease (CHD) is when your coronary arteries become narrowed by a gradual build-up of fatty material within their walls called atherosclerosis. These arteries supply your heart muscle with oxygen-rich blood. The most common symptom of coronary heart disease (CHD) is chest pain.. You can also experience other symptoms, such as a light headed sensation, palpitations and shortness of breath. Some people may not have any symptoms before they are diagnosed.. Your arteries may become so narrow that they cannot deliver enough oxygen-rich blood to your heart. The pain and discomfort you may feel as a result is called angina.. If a piece of atheroma breaks off it may cause a blood clot to form. If it blocks your coronary artery and cuts off the supply of oxygen-rich blood to your heart muscle, your heart may become permanently damaged. This is known as a heart attack.. There are several ways you can help reduce your risk of developing coronary heart disease (CHD), such as lowering your ...
In the article by Williams et al, Is Optimal Medical Therapy Optimal Therapy for Multivessel Coronary Artery Disease?: Optimal Management of Multivessel Coronary Artery Disease, which appeared in the September 7, 2010 issue of the journal (Circulation 2010;122:943-945), there were two typographical errors:. On page 943, in the fourth paragraph Coronary Artery Surgical Study should read Coronary Artery Surgery Study.. In the same paragraph, European Coronary Surgical Study should read European Coronary Surgery Study.. The text has been corrected in the current online version of the manuscript. The authors regret the error.. ...
Baseline characteristics were compared between people with and without a family history of premature CHD. A Student t test was used for continuous variables (age, body mass index, waist circumference, waist/hip ratio, systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol) a χ2 test was used for categorical variables (sex, smoking status, diabetes mellitus). Because triglycerides and the FRS were not normally distributed, these parameters were log-transformed. The log-transformed variables were normally distributed and were compared using a Student t test.. The Framingham risk score was calculated using a previously reported algorithm, which takes into account age, sex, total cholesterol, HDL cholesterol, systolic and diastolic blood pressure, smoking and the presence of diabetes. Since the FRS overestimates CHD risk in Europeans, and more specifically in the EPIC-Norfolk study population, we recalibrated ...
Psychosocial characteristics have been linked to coronary heart disease. In the Belgian Job Stress Project (1994-1999), the authors examined the independent role of perceived job stress on the short-term incidence of clinical manifest coronary events in a large occupational cohort. A total of 14,337 middle-aged men completed the Job Content Questionnaire to determine the dimensions of the extended job strain model, job demands, decision latitude, and social support. Jobs were categorized into high strain, low strain, active jobs, and passive jobs. During the 3-year follow-up, 87 coronary events were registered. At baseline, 17% of workers experienced high strain. Job demands and decision latitude were not significantly related to the development of coronary heart disease after adjustment for covariates. The 38% risk excess among subjects classified in the high-strain category did not reach statistical significance. However, coronary heart disease incidence was substantially associated with the ...
Background: Lifestyle changes and drug treatment can improve the prognosis and quality of life for patients with coronary heart disease (CHD), but their co-operation with suggested treatment is often limited. The aim of this thesis was to study how patients and their spouses conceive CHD and its treatment.. Material and Methods: The research design used was inductive and descriptive. The studies were based on three complementary sets of data. Patients with CHD (n=23) and spouses (n=25) were interviewed one year after an episode of the disease. Consecutive patients with CHD derived from another investigation were interviewed within six weeks or one year after the coronary event (n=113). All semi-structured interviews, tape-recorded or from notes taken by hand, were subjected to analysis within the phenomenographic framework.. Findings: The patients conceptions of CHD varied and were vague, even as judged on a lay level. They were associated with symptoms rather than with the disease. ...
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping. ...
Many patients with coronary disease and a positive exercise test have episodes of ST-segment depression during ambulatory monitoring, the majority of which are silent.42 43 44 45 46 47 48 49 Surprisingly, ambulatory ischemia monitoring has not been widely applied in the assessment of asymptomatic ischemia in diabetics. Chiariello et al15 compared the incidence of ambulatory ischemia during 24-hour AECG monitoring among 51 patients with diabetes (74% of whom had evidence of coronary disease), 70 nondiabetic patients with coronary disease, and 40 nondiabetic patients without overt coronary disease. They reported that 36% of the diabetic patients had at least one episode of asymptomatic ischemia, significantly higher than the 17% of patients in the nondiabetic group with coronary disease. Additionally, 73% of the total episodes of ST-segment deviation in the diabetic group were asymptomatic, significantly higher than the 60% of episodes in the nondiabetic group. These data cannot be directly ...
We have found that both mean and maximum measurements of CCA and ICA IMT are heritable. Heritability estimates using correlation coefficients and variance components methods are similar, and the magnitude of heritabilities for carotid IMT is similar to those reported for other quantitative cardiovascular traits such as systolic blood pressure and serum cholesterol. These data suggest that a substantial proportion of the variability in carotid IMT is explained by genetic factors.. Carotid IMT is a marker of subclinical cardiovascular disease that has been shown to be associated with traditional coronary heart disease risk factors3-6 and coronary atherosclerotic burden7,8 and to be predictive of subsequent cardiovascular events.9,10 Multiple prior studies have demonstrated the contribution of genetic factors to individual coronary heart disease risk factors, including systolic blood pressure,23 HDL cholesterol,24 and diabetes mellitus.25 A large study of 21 000 twins demonstrated an increased risk ...
TY - JOUR. T1 - The genetics of coronary heart disease: The contribution of twin studies. AU - Evans, A. AU - Van Baal, G.C.M.. AU - McCarron, Peter. AU - DeLange, M.. AU - Soerensen, T.I.A.. AU - De Geus, E.J.C.. AU - Kyvik, K.. AU - Pedersen, N.L.. AU - Spector, T.D.. AU - Andrew, T.. AU - Patterson, Christopher. AU - Whitfield, J.B.. AU - Zhu, G.. AU - Martin, N.G.. AU - Kaprio, J.. AU - Boomsma, D.I.. PY - 2003/10. Y1 - 2003/10. N2 - Despite the decline in coronary heart disease in many European countries, the disease remains an enormous public health problem. Although we know a great deal about environmental risk factors for coronary heart disease, a heritable component was recognized a long time ago. The earliest and best known examples of how our genetic constitution may determine cardiovascular risk relate to lipoprotein(a), familial hypercholesterolaemia and apolipoprotein E. In the past 20 years a fair number of polymorphisms assessed singly have shown strong associations with the ...
Coronary heart disease remains a leading cause of mortality in the United States, with 84 percent of persons 65 years or older dying from this disease. Secondary preventive measures, including lifestyle modification and pharmacotherapy, are important for elderly patients because of the variable impacts on morbidity and mortality rates and quality of life. Participating in light to moderate activities significantly decreases mortality rates in elderly patients. Smoking cessation translates into a reduction in overall mortality and morbidity rates at least equal to that of other preventive measures such as aspirin or beta-blocker therapy. Recent studies on the effects of lowering low-density lipoprotein cholesterol levels to below 100 mg per dL have shown a substantial reduction in coronary heart disease mortality and nonfatal myocardial infarction rates, with a persistent effect in patients older than 75 years. Hypertension, manifesting mostly as isolated systolic blood pressure elevation, also should be
In this analysis of the data from a longitudinal study on coronary heart disease risk factors, it was found that participants screened a few weeks after a major disaster (earthquake) had a higher heart rate, serum cholesterol levels, and serum triglyceride levels than matched participants that were screened shortly before the catastrophic event. The two groups of participants did not differ with regard to their characteristics at the baseline examination carried out 5 years previously. The lack of difference in blood pressure between exposed and nonexposed participants could be explained by the lag-time between the earthquake and the blood pressure measurements. We conclude that the acute stress associated with major disasters can influence risk factors for coronary heart disease. Permanent elevation of these risk factors due to the disruption of the social environment of the individuals affected by major disasters might be responsible for the apparent long-term adverse effects on cardiovascular ...
Title: Depression in Coronary Heart Disease Patients: Etiological and Screening Issues. VOLUME: 2 ISSUE: 2. Author(s):Colin R. Martin and David R. Thompson. Affiliation:Faculty of Medicine, TheNethersole School of Nursing, Chinese University of Hong Kong, EstherLee Building, Chung Chi College, Shatin, New Territories, Hong Kong,Peoples Republic of China.. Keywords:selective serotonin re-uptake inhibitor (SSRI), sertraline anti-depressant heart attack randomised, trial (SADHART), cardiac rehabilitation (CR), PHQ-2, CHD risk factor. Abstract: Coronary heart disease (CHD) is associated with significant psychiatric comorbidity, in particular, depression. Recent evidence suggests that depression following a coronary event or diagnosis is a significant risk factor for both mortality and morbidity. Further, there is compelling evidence that depression is a significant predictor in the development of CHD. Surprisingly, given the relationship of depression to patient outcome, screening for depressive ...
Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase ...
TY - JOUR. T1 - Coronary heart disease mortality trends in Minnesota, 1960-80. T2 - The Minnesota heart survey. AU - Gillum, R. F.. AU - Hannan, P. J.. AU - Prineas, R. J.. AU - Jacobs, D. R.. AU - Gomez-Marin, O.. AU - Luepker, R. V.. AU - Baxter, J.. AU - Kottke, T. E.. AU - Blackburn, H.. PY - 1984/1/1. Y1 - 1984/1/1. N2 - Age-adjusted mortality rates and trends from coronary heart disease (CHD) in Minnesota for the years 1960 to 1980 differed among eight health service areas. Regression of ten socio-economic and demographic factors and intensive care and coronary care unit beds on area CHD mortality levels revealed a significant positive association only for levels of welfare income-maintenance assistance with CHD mortality levels; there were no associations with trends. Further studies are needed to explain variation within states of CHD mortality rate levels and trends.. AB - Age-adjusted mortality rates and trends from coronary heart disease (CHD) in Minnesota for the years 1960 to 1980 ...
HealthDay News - Incident coronary heart disease (CHD) is associated with accelerated cognitive decline after, but not before, the event, according to a study published in the June 25 issue of the Journal of the American College of Cardiology.. Wuxiang Xie, PhD, from the Peking University Health Science Center in Beijing, and colleagues examined the cognitive trajectory before and after incident CHD diagnosis in a cohort of 7888 participants with no history of stroke or incident stroke during follow-up. Participants underwent a cognitive assessment at baseline in 2002 to 2003 and at least one other time point (from 2004-2005 to 2016-2017). Incident CHD was defined as a diagnosis of myocardial infarction and/or angina during follow-up.. The researchers observed a correlation for incident CHD with accelerated cognitive decline during a median follow-up of 12 years. The annual rate of cognitive decline was similar before CHD diagnosis for individuals who experienced incident CHD and for those who ...
TY - JOUR. T1 - Employment and recreation patterns in patients treated by percutaneous transluminal coronary angioplasty. T2 - A multicenter study. AU - Holmes, David. AU - Vlietstra, Ronald E.. AU - Mock, Michael B.. AU - Smith, Hugh C.. AU - Dorros, Gerald. AU - Cowley, Michael J.. AU - Kent, Kenneth M.. AU - Hammes, La Von N.. AU - Janke, Lynne. AU - Elveback, Lila R.. AU - Vetrovec, George W.. PY - 1983/10/1. Y1 - 1983/10/1. N2 - Employment and recreational patterns were analyzed in 279 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) for treatment of symptomatic coronary artery disease. PTCA was successful in 180 patients (65%). When it was unsuccessful, coronary artery bypass graft surgery was usually performed (80%). Return-to-work rates were high irrespective of the outcome of PTCA. Of patients employed full-time or part-time before treatment, 98.5% of those who had successful PTCA alone and 97% of those whose PTCA was unsuccessful but who underwent ...
Background The prevalence of coronary heart disease amongst South Asian population in the UK is higher compared to the general population. Objective This study sought to investigate beliefs and experiences of South Asian patients regarding coronary heart disease and medication taking behaviour. Setting A London Heart Attack Centre. Methods This mixed method study is part of an original pilot randomised study on 71 patients involving a pharmacy-led intervention to improve medication adherence in coronary heart disease patients. South Asian patients from the randomised study took part in qualitative semi-structured telephone interviews. Both South Asian and non-South Asian patients completed the questionnaire about adherence and beliefs regarding medicines using Morisky Scale and the Belief About Medicines Questionnaire-Specific at 2 weeks, 3 and 6 months. Outcome Patients beliefs about coronary heart disease and medication adherence. Results Seventeen South Asian patients and 54 non-South Asian ...
Despite advances made in treating coronary heart disease (CHD), mortality due to CHD in Syria has been increasing for the past two decades. This study aims to assess CHD mortality trends in Syria between 1996 and 2006 and to investigate the main factors associated with them. The IMPACT model was used to analyze CHD mortality trends in Syria based on numbers of CHD patients, utilization of specific treatments, trends in major cardiovascular risk factors in apparently healthy persons and CHD patients. Data sources for the IMPACT model included official statistics, published and unpublished surveys, data from neighboring countries, expert opinions, and randomized trials and meta-analyses. Between 1996 and 2006, CHD mortality rate in Syria increased by 64%, which translates into 6370 excess CHD deaths in 2006 as compared to the number expected had the 1996 baseline rate held constant. Using the IMPACT model, it was estimated that increases in cardiovascular risk factors could explain approximately 5140 (81%
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The most abundant steroid in the human body, dehydroepiandrosterone (DHEA) is involved in the manufacture of testosterone, estrogen, progesterone, and corticosterone. Claes Ohlsson, from Sahlgrenska Academy (Sweden), and colleagues monitored 2,614 men, ages 69 to 80 years, who resided in 3 Swedish communities, for five years, during which DHEA levels were assessed. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up. The study authors report that: Low serum levels of DHEA and its sulfate predict an increased risk of [coronary heart disease], but not [cerebrovascular disease], events in elderly men.. Asa Tivesten; Liesbeth Vandenput; Daniel Carlzon; Maria Nilsson; Magnus K. Karlsson; Claes Ohlsson; et al. Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men. J Am Coll Cardiol. 2014; 64(17):1801-1810.. ...
A comprehensive study in this weeks PLoS Medicine shows levels of the amino acid, homocysteine, have no meaningful effect on the risk of developing coronary heart disease, closing the door on the previously suggested benefits of lowering homocysteine with folate acid once and for all.. Previous studies have suggested that high blood levels of homocysteine might be a modifiable risk factor for coronary heart disease, but in a detailed analysis of data from 19 unpublished and 86 published studies, led by Robert Clarke from the Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford, the researchers found that lifelong moderate elevation of homocysteine levels had no significant effect on the risk of developing coronary heart disease. The study findings suggest that extensive publication bias, together with methodological problems, has played a role in previous suggestions linking homocysteine with coronary heart disease risk.. In their analysis, the authors found ...
TY - JOUR. T1 - A comparison of coronary heart disease event rates amoung urban Australian Aboriginal people and a matched non-Aboriginal population. AU - Bradshaw, Pamela. AU - Alfonso-Parada, Helman. AU - Finn, Judith. AU - Owen, Julie. AU - Thompson, Peter. PY - 2011. Y1 - 2011. U2 - 10.1136/jech.2009.098343. DO - 10.1136/jech.2009.098343. M3 - Article. VL - 65. SP - 315. EP - 319. JO - Journal of Epidemiology & Community Health. JF - Journal of Epidemiology & Community Health. SN - 0143-005X. ER - ...
PURPOSE: In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.METHODS: Data on 13,051 patients ages 45 to 64 years from the Atherosclerosis Risk in Communities study were analyzed. The ARIC food frequency questionnaire baseline data provided GI and GL indices. A propensity score was created to estimate the effect of a patients covariates on energy-adjusted GI or GL. During a maximum of 17 years of follow-up, 1683 cases of CHD (371 with diabetes and 1312 without diabetes) were recorded.RESULTS: For every 5-units increase in GI, there was a 1.16-fold (95% confidence interval [95% CI], 1.01-1.33) increased risk of incident CHD in African Americans. For every 30-units increase in GL, there was a 1.11-fold (95% CI, 1.01-1.21) increased risk of incident CHD in Whites. High GL was an especially important CHD risk factor for ...
Design, setting and participants: A CVD risk-factor survey was carried out in rural south-eastern Australia from 2004 to 2006. Using a stratified random sample, data for 1116 participants aged 35-74 years were analysed. Applying the Framingham risk equations to risk-factor data, 5-year probabilities of a coronary heart disease event, stroke and cardiovascular event were calculated. The effect of different changes in risk factors were modelled to assess the extent to which cardiovascular diseases can be prevented by changing the risk factors at a population level (population strategy), among the high-risk individuals (high-risk strategy) or both ...
Using mortality data from National Institute of Statistics in Spain, we analyzed trends of infectious disease mortality rates in Spain during 1980-2011 to provide information on surveillance and control of infectious diseases. During the study period, 628,673 infectious disease-related deaths occurred, the annual change in the mortality rate was −1.6%, and the average infectious disease mortality rate was 48.5 deaths/100,000 population. Although the beginning of HIV/AIDS epidemic led to an increased mortality rate, a decreased rate was observed by the end of the twentieth century. By codes from the International Classification of Diseases, 9th revision, the most frequent underlying cause of death was pneumonia. Emergence and reemergence of infectious diseases continue to be public health problems despite reduced mortality rates produced by various interventions. Therefore, surveillance and control systems should be reinforced with a goal of providing reliable data for useful decision making.
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Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. Clinical data,operative success rate,locations of coronary artery lesions,number of implanted stents,clinical outcome,hospitalization related expenses and incidence of complications were compared between the two groups. Results Patients of the two groups completed the operation successfully,the operative success rates of the two
JA Allen, LA Throm; Percutaneous transluminal coronary angioplasty: a new alternative for ischemic heart disease. Crit Care Nurse 1 January 1982; 2 (1): 24-29. doi: https://doi.org/10.4037/ccn1982.2.1.24. Download citation file:. ...
Percutaneous transluminal coronary angioplasty (PTCA) is a minimally invasive procedure to open up blocked coronary arteries, allowing blood to circulate unobstructed to the heart muscle. Market Analysis and Insights: Global Percutaneous Translumi
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Background. The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.. Methods. Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randoxs Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).. Results. Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the ...
In the present study of older community-dwelling individuals, Lp-PLA2 levels were significantly higher in those who developed CHD compared with those who did not. Associations between Lp-PLA2 and LDL, HDL, total cholesterol, and triglycerides were especially strong, and the magnitude of the correlations was in good agreement with previous studies (7,19). Despite these associations, Lp-PLA2 remained a strong and independent predictor of fatal and nonfatal CHD events, over and above these and other traditional risk factors. Thus, Lp-PLA2 added information to lipid and lipoprotein prediction of future CHD and may identify subpopulations at risk for CHD who would not be identified otherwise.. A similar independent association of Lp-PLA2 with CHD risk was reported in the younger participants from the WOSCOPS (5) and ARIC (7,19) studies and in a nested case-control study from the Rotterdam study (9). We now confirm these results for the first time in a cohort of apparently healthy older men and women ...
Finland has marked regional differences in the occurrence of coronary heart disease (CHD). Although the causes for these differences in CHD mortality and morbidity in the Finnish population are unknown, it offers an excellent opportunity to investigate the effects of non-insulin-dependent diabetes mellitus (NIDDM) on CHD risk in two populations differing significantly with respect to the occurrence of CHD. Therefore, we carried out a 7-year prospective population-based study including a large number of patients with NIDDM (East Finland: 253 men and 257 women; West Finland: 328 men, 221 women) and corresponding non-diabetic subjects (East Finland: 313 men, 336 women; West Finland: 325 men, 399 women). In both study populations the presence of NIDDM increased significantly the risk for CHD events (CHD mortality or all CHD events including CHD mortality or non-fatal myocardial infarction). Diabetic men had 3-4 fold higher and diabetic women 8-11-fold higher risk for CHD than corresponding non-diabetic
Subclinical heart disease has been reported to be an independent predictor of CAD risk in the general population. Women with subclinical disease were at greater risk for acute MI.47 Early investigation for CAD in the preclinical stage in young women with SLE is justified because cardiovascular events are an important cause of morbidity and mortality in this population. Published reports show that coronary disease (angina pectoris or acute MI) is more common in women with SLE than in the general population. Moreover, the mean age of patients with SLE who had coronary disease was younger than seen in the general population.4. We studied patients with more than five years of SLE, who had used steroids for at least one year, in attempt to evaluate patients at a greater risk for CAD.10-11,16,48 We analysed only asymptomatic patients, because we wanted to investigate subclinical heart disease. We also excluded patients older than 55 years, because women after this age have higher risk for CAD than ...
Coronary heart disease (CHD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. You can read more information on this at the National Heart Lung and Blood Institute website.. We had this requirement come in from a partner on how we could store all the patient vital data within Dynamics 365 and calculate a risk score. Our example shows how to use North52s business rules engine for Dynamics 365 to set up a Multi-Sheet Decision Table to evaluate the patients risk score of Coronary Heart Disease.. Each Decision Table Sheet will evaluate specific Risk Factors with a variety of Conditions and decide if that risk factor applies to the patient. A final Decision Table Sheet will then provide a Risk Score based on the individual Risk Factors.. For this article it is assumed that you have at least basic familiarity with Decision Tables and/or have read the following articles:. ...
A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD). Many clinical trials aimed to test this advice and have had their results pooled in several meta-analyses. However, earlier meta-analyses did not sufficiently account for major confounding variables that were present in some of those trials. Therefore, the aim of the study was to account for the major confounding variables in the diet heart trials, and emphasise the results from those trials that most accurately test the effect of replacing SFA with mostly n-6 PUFA.. Design Clinical trials were identified from earlier meta-analyses. Relevant trials were categorised as adequately controlled or inadequately controlled depending on whether there were substantial dietary or non-dietary differences between the experimental and control groups that were not related to SFA or mostly n-6 PUFA ...
Coronary heart disease (CHD) is the most common cause of death and disability in the United Kingdom. It causes around 94,000 deaths in the UK each year and around one in five men and one in seven women will die from the disease.. Coronary heart disease is usually caused by atherosclerosis, where fatty deposits (atheroma) develop in the walls of the arteries. Atherosclerosis causes symptoms when it partially or completely blocks the arteries that supply the heart muscle with blood. This manifests as a number of conditions including stable angina (where atheroma restricts blood flow) and acute coronary syndromes (where clot formation occurs on the atheroma and causes an abrupt narrowing or complete blockage of the artery). These are described in the relevant sections.. There are two ways to improve blood flow to heart muscle when the arteries become blocked. Percutaneous Coronary Intervention (PCI) and surgical coronary artery bypass grafting (CABG).. PCI is performed under local anaesthetic. A ...
May 25, 2005 -- WASHINGTON -- The U.S. Preventive Services Task Force (USPSTF) recommends against the routine use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women. The USPSTF found good evidence that the use of combined estrogen and progestin results in both benefits and harms. Benefits include reduced risk for fracture (good evidence) and colorectal cancer (fair evidence). Combined estrogen and progestin has no beneficial effect on coronary heart disease and may even pose an increased risk (good evidence). Other harms include increased risk for breast cancer (good evidence), venous thromboembolism (good evidence), stroke (fair evidence), cholecystitis (fair evidence), dementia (fair evidence), and lower global cognitive function (fair evidence). Because of insufficient evidence, the USPSTF could not assess the effects of combined estrogen and progestin on the incidence of ovarian cancer, mortality from breast cancer or coronary heart disease, ...
Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease (CHD) risk ...
Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease (CHD) risk ...
In recent years there has been growing interest in coronary artery disease in women, particularly with regard to gender differences. We know from the Framingham study that women develop coronary disease at an older age and often have different presenting manifestations. For example, women are more likely to have chest pain as their initial symptom (1). Several studies have investigated gender differences with respect to outcome after myocardial infarction but relatively few have examined outcomes after diagnosis of angina. The study by Orencia and colleagues compares outcomes in men and women with angina pectoris. The diagnosis of angina was based on symptoms alone and did not require objective evidence of ischemia. Details regarding the character of chest pain or the frequency of typical compared with atypical pain were not provided. The finding of a more favorable prognosis in women with an initial diagnosis of angina is encouraging but may be misleading. As the authors acknowledge, angina is ...
Coronary Heart Disease in Egypt, Coronary Heart Disease statistics, According to the latest WHO data published in 2017. Number of deaths: 126,312 (24.58%) Death Rate (Deaths per 100,000 population): 216.82 Cause of death world rank: 18. Coronary Heart Disease, listed as the underlying cause of death, accounts fo...
Coronary Heart Disease in Comoros, Coronary Heart Disease statistics, According to the latest WHO data published in 2017. Number of deaths: 289 (5.64%) Death Rate (Deaths per 100,000 population): 92.29 Cause of death world rank: 124. Coronary Heart Disease, listed as the underlying cause of death, accounts for nea...
BACKGROUND: Although primary care physicians understand the importance of preventive services for patients with multiple risk factors (MRF) for coronary heart disease, physician intervention is limited. This study investigated (1) physicians views of challenges faced in managing patients with MRF; (2) the counseling and management methods they utilize; and (3) possible strategies to enhance MRF intervention in the primary care setting. METHODS: Two focus groups were conducted with primary care physicians from varying settings to gain insight into these issues noted above. Each group was co-facilitated by a physician and a behavioral scientist using a previously developed semistructured interview guide. The group discussions were tape recorded and subsequently transcribed. Transcripts were analyzed using the constant comparative method for analysis. RESULTS: Physicians are challenged by knowledge limitations (contribution of individual risk factors to overall risk); limited support (guidelines,
"Coronary Heart Disease". Weitz & Luxenberg P.C. Archived from the original on May 30, 2013. Retrieved March 20, 2013. "Kidney ... A headache in a patient taking medication for influenza may be caused by the underlying disease or may be an adverse effect of ... Adverse effects may cause complications of a disease or procedure and negatively affect its prognosis. They may also lead to ... "Possible Side-effects from Vaccines". Centers for Disease Control and Prevention (CDC). 2018-07-12. Archived from the original ...
Coronary heart disease, also known as coronary artery disease, is one of the most common causes of myocardial damage, affecting ... In Coronary heart disease the coronary arteries narrow due to the buildup of atheroma or fatty deposits on the vessel walls. ... "CORONARY HEART DISEASE". Merriam-Webster. Retrieved 2020-03-23. CDC (2019-11-22). "What are Congenital Heart Defects? , CDC". ... The accumulation of the fibrotic tissue is much slower in coronary heart disease compared to an infarction because the tissue ...
Coronary Artery Disease. 23 (6): 368-74. doi:10.1097/MCA.0b013e3283564930. PMID 22735090. S2CID 2870694. Oliveira AG, Marques ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the peritoneal fluid. It binds ... Mustafa SJ, Morrison RR, Teng B, Pelleg A (2009). "Adenosine receptors and the heart: role in regulation of coronary blood flow ...
Coronary heart disease has been one of the leading cause of death in ethnic groups. One study found that PM2.5 exposure ... keller, colleen (1993). "Coronary heart disease in ethnic minorities". ovid.org. Hajat, Anjum; Diez-Roux, Ana V.; Adar, Sara D ... Some long-term health effects are lung cancer and respiratory diseases, heart disease, and organ damage, and irreversible nerve ... are also known to have an association with the cardiovascular diseases. This increased risk of cardiovascular diseases by ...
He died from a coronary disease. First Prize Fray Bentos, Uruguay, 1970. Martin Fierro Award for the best music radio program, ...
Miller, Rusty (November 16, 1995). "Coronary disease kills Horvath at 74". The Daily Sentinel. Columbus, Ohio. p. 5. Retrieved ...
95P-0197; RIN 0910-AA19; Food Labeling: Health Claims; Oats and Coronary Heart Disease" (PDF). US Food and Drug Administration ... coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006". EFSA Journal. 8 (12): 1885. doi:10.2903/j.efsa ... ruling by the Food and Drug Administration that consuming oat bran or whole rolled oats can lower the risk of heart disease ...
Russ was a co-editor, with Valentín Fuster and Eric J. Topol, of the textbook Atherosclerosis and Coronary Artery Disease. He ... 2005). Atherothrombosis and Coronary Artery Disease. Lippincott Williams & Wilkins. p. xxv of Preface. ISBN 9780781735834.. ...
"Coronary heart disease and drinking water". Journal of Chronic Diseases. 28 (5-6): 259-287. doi:10.1016/0021-9681(75)90009-0.. ... the presence of metals in drinking water and their possible relationships to coronary heart disease. "Archive materials". Aalto ...
Keys, Ancel (1975). "Coronary Heart Disease - The Global Picture". Atherosclerosis. 22 (2): 149-192. doi:10.1016/0021-9150(75) ... 1] "sugar consumption and cigarette smoking" Keys, A. (1971). "Sucrose in the diet and coronary heart disease". Atherosclerosis ... Keys, Ancel (1971). "Sucrose in the Diet and Coronary Heart Disease". Atherosclerosis. 14 (2): 193-202. doi:10.1016/0021-9150( ... Yudkin, John (1965). "Evolution, History and Nutrition: Their Bearing on Oral Disease and Other Diseases of Civilisation". ...
... severe heart failure or coronary artery disease. Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, ... Given the importance of insulin resistance as a risk factor for cardiovascular disease, it is of considerable relevance that it ... such as kidney disease and cardiac hypertrophy. Effects on insulin resistance In all animal models of insulin resistance, ... Parkinson's disease, glaucoma. Use in pregnancy is discouraged. Moxonidine passes into breast milk. Excess mortality has been ...
However, according to data from the British Heart Foundation, in 1999, rates of death from coronary heart disease among males ... Clarke, Robert; Lewington, Sarah (2006). "Trans fatty acids and coronary heart disease". BMJ. 333 (7561): 214. doi:10.1136/bmj. ... "A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease". Arch Intern ... It has been suggested that a higher intake of fruit and vegetables in the diet may lower the risk of cardiovascular diseases. ...
An autopsy showed advanced coronary artery disease. Every year (since 2003) is organized Memorial of Hubert Jerzy Wagner, which ...
reporting on Clarke R, Lewington S (July 2006). "Trans fatty acids and coronary heart disease". BMJ. 333 (7561): 214. doi: ... "higher intakes of TFA may increase risk for coronary heart disease". From 2 April 2021 foods in the EU intended for consumers ... trans fat labeling will have prevented from 600 to 1,200 cases of coronary artery disease, and 250 to 500 deaths, yearly. This ... conferring a substantially increased risk of coronary artery disease death. NICE made three specific recommendation for diet: ( ...
"Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized ... "Exercise-based cardiac rehabilitation for coronary heart disease". Cochrane Database of Systematic Reviews (2): CD001800. doi: ...
The myopathy of coronary artery disease". The American Journal of Cardiology. 34 (5): 520-525. doi:10.1016/0002-9149(74)90121-0 ... it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. This ... "Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in people with ischemic ... Hodler, Jurg (2015). Diseases of the Chest and Heart: Diagnostic Imaging and Interventional. Springer. p. 146. ISBN 978-88-470- ...
A recent study done in Pondicherry, India, shows its importance in coronary artery disease. Hemoglobin concentration ... The best known hemoglobinopathy is sickle-cell disease, which was the first human disease whose mechanism was understood at the ... Emerging marker in stable coronary artery disease". Chronicles of Young Scientists. 2 (2): 109. doi:10.4103/2229-5186.82971. ... A heterozygous form causing sickle cell trait with one adult gene and one sickle cell disease gene Hemoglobin SC disease - A ...
A new therapeutic approach in coronary heart disease]". Herz (in German). 25 (6): 589-99. doi:10.1007/PL00001972. PMID 11076317 ... Angiogenesis may be a target for combating diseases such as heart disease characterized by either poor vascularisation or ... The most commonly occurring disorders in humans, such as heart disease, high blood pressure, diabetes and Alzheimer's disease, ... for the treatment of coronary artery disease. Regarding the mechanism of action, pro-angiogenic methods can be differentiated ...
Less than 20% of all cases of chest pain admissions are found to be due to coronary artery disease. The rate of chest pain as a ... Chun AA, McGee SR (September 2004). "Bedside diagnosis of coronary artery disease: a systematic review". The American Journal ... In adults the most common causes of chest pain include: gastrointestinal (42%), coronary artery disease (31%), musculoskeletal ... history of coronary artery disease or stroke, positive family history (premature atherosclerosis, cholesterol disorders, heart ...
Vlodaver, Zeev; Wilson, Robert F.; Garry, Daniel J. (31 January 2012). Coronary Heart Disease: Clinical, Pathological, Imaging ... Marso, Steven P.; Stern, David M. (2004). Diabetes and Cardiovascular Disease: Integrating Science and Clinical Medicine. ... efficacy refers to the capacity of regulated glycemic levels to produce an effect in people with diabetes and heart disease. ...
"The Adventist Health Study: findings for coronary heart disease". Loma Linda University. Retrieved 2008-05-31. "The Adventist ... lower Coronary heart disease 34% lower for Adventist men, 2% lower for Adventist women An additional study (1974-1988) involved ... linking diet to cancer and coronary heart disease. Specifically: On average Adventist men live 7.3 years longer and Adventist ... Seventh-day Adventists have a lower risk than other Americans of certain diseases, and many researchers hypothesize that this ...
However, this study only included patients with coronary disease. The lower frame rate has been seen to be a problem in stress ...
Being stressed out at work can lead to hypertension; however, it can also lead to coronary heart disease. It is nearly ... At the same rate, the leading causes of death (Heart disease, cancer, stroke and chronic lower respiratory diseases- see https ... More children and adolescents die as a result of an unintentional injury than from all other childhood diseases combined. ... Haynes, R.B. (1979). Determinants of compliance: The disease and the mechanics of treatment. Baltimore MD, Johns Hopkins ...
Critchley, Julia A.; Unal, Belgin (April 2004). "Is smokeless tobacco a risk factor for coronary heart disease? A systematic ... Asplund, Kjell (2003). "Smokeless tobacco and cardiovascular disease". Progress in Cardiovascular Diseases. 45 (5): 383-94. doi ... Centers for Disease Control and Prevention (1999). "Determination of Nicotine, pH, and Moisture Content of Six US Commercial ... Increased risk of cardiovascular diseases and mortality because of snuff]. Läkartidningen (in Swedish). 94 (42): 3725-31. PMID ...
Patient had coronary artery disease and severe mitral valve leak. Patient had combined robotic mitral valve replacement and ... Pulmonary Thromboendarterectomy for chronic pulmonary thrombo embolic disease, Aortic Aneurysm Repair, Surgery for Cardiac ... coronary artery bypass surgery. India's first Robotic Aortic Valve Replacement, 2010. 18-year-old patient with complaints of ...
An autopsy concluded that Dunn died of coronary artery disease. Minnesota authorities were tipped off by the Georgia Bureau of ... She falsely claimed to have a myriad of physical diseases and expressed a belief that she may have had breast cancer. Two ...
Bierman EL, Shank RE (November 1975). "Editorial: Homogenized milk and coronary artery disease: theory, not fact". JAMA. 234 (6 ... "Vitamin D Coronavirus Disease COVID-19". COVID-19 Treatment Guidelines (US Centers for Disease Control and Prevention). ... Tsouderos, Trine (April 26, 2011). "FDA warns doctor: Stop touting camera as disease screening tool Archived January 12, 2020, ... COVID-19 disease. As he pronounces his name on his own videos, e.g. [1] Archived 2021-02-16 at the Wayback Machine. Smith, ...
"The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research ...
In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly ... "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 361 (26): 2538-2547. ... "Health Conditions: Diseases, conditions & medical information - MSN Health & Fitness". healthyliving.msn.com. Retrieved 12 ... 1-28, retrieved 2020-06-19 marieb, elaine (2004) black, joyce (2005) Braunwald's Heart Disease. Elsevier Saunders. 2015. p. 433 ...
June 2007). "A common allele on chromosome 9 associated with coronary heart disease". Science. 316 (5830): 1488-91. doi:10.1126 ... Identified the strongest genetic risk factor for coronary artery disease and heart attack to date (the 9p21 gene)-the first ... More than 1,900 open-heart procedures at UOHI each year require anesthesia, including coronary artery bypass, valve replacement ... the Champlain Cardiovascular Disease Prevention Network, the Ottawa Model for Smoking Cessation (implemented in more than 200 ...
"Intercessory Prayer and Cardiovascular Disease Progression in a Coronary Care Unit Population: A Randomized Controlled Trial". ... while imbalance results in disease. Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, ... A belief that a substance that causes the symptoms of a disease in healthy people cures similar symptoms in sick people.[n 8] ... Treatments for severe diseases such as cancer and HIV infection have well-known, significant side-effects. Even low-risk ...
Acceleration of Atherosclerosis After Lactobacillus casei-Induced Coronary Arteritis in a Mouse Model of Kawasaki Disease, ... Nerve growth factor circulating levels are increased in Kawasaki disease: correlation with disease activity and reduced ...
Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... 2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease». Gastroenterology. 139 (1): ...
... coronary heart disease, and cerebrovascular disease, because they ate mostly lean meats and plants and frequently engaged in ... caused by other factors such as disease and overhunting by humans.[16][17] New research suggests that the extinction of the ... It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ... "Hunter-gatherer diets: wild foods signal relief from diseases of affluence (PDF)" (PDF). In Ungar, Peter S.; Teaford, Mark F. ...
2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161 ... "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 ... haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular medicine (Cambridge, ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... starting at higher doses may cause acute coronary syndrome or an arrhythmia.[11] ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ... Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress ...
There is an increased risk of coronary heart disease. Cardiomyopathy and muscular dystrophy may occur rarely. Xanthoma and nail ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Herbst KL, Tannock LR, Deeb ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ...
House, J.S. (1974). Occupational stress and coronary heart disease: A review and theoretical integration. Journal of Health and ... Cardiovascular disease[edit]. Main articles: Occupational stress and Cardiovascular disease. Research has identified health- ... 2017). Effort-reward imbalance at work and incident coronary heart disease: A multi-cohort study of 90,164 individuals. ... Toker, S., Melamed, S., Berliner, S., Zeltser, D., & Shapira, I. (2012). Burnout and risk of coronary heart disease: a ...
2006). "Low-carbohydrate-diet score and the risk of coronary heart disease in women". N. Engl. J. Med. 355 (19): 1991-2002. doi ... "Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial". Lancet. 336 (8708): 129-133. doi:10.1016/0140 ... found that low carbohydrate diets based on vegetable sources of fat and protein are associated with less coronary heart disease ... between animal fat intake and coronary heart disease (table 4). A long term study that monitored 43,396 Swedish women however ...
... and blood pressure in those with coronary heart disease (CHD).[37]. StrokeEdit. Music is useful in the recovery of motor skills ... "Music for stress and anxiety reduction in coronary heart disease patients". The Cochrane Database of Systematic Reviews (12): ... Heart diseaseEdit. According to a 2013 Cochrane review, listening to music may improve heart rate, respiratory rate, ... Aesculapius was said to cure diseases of the mind by using song and music, and music therapy was used in Egyptian temples. ...
... and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants.. ... Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review ... A.M.A. Recognizes Obesity as a Disease. New York Times. 2013-06-18 [2015-11-19]. (原始内容存档于2013-06-23).. ... Centers for Disease Control and Prevention. 2007-05-22 [2007-09-05]. (原始内容存档于2007-10-
Soluble fiber from certain foods and risk of coronary heart disease (CHD).[3] ... Soluble fiber from certain foods and risk of coronary heart disease (CHD) ... 3.0 g of β-glucan from oats per day decreased absorption of dietary cholesterol and reduced the risk of coronary heart disease ... Zeković, Djordje B. (10 October 2008). "Natural and Modified (1→3)-β-D-Glucans in Health Promotion and Disease Alleviation". ...
Other uncommon causes are Trousseau disease,[medical citation needed] Beurger's disease (Thromboangiitis obliterans),[medical ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... One in five of the middle-aged (65-75 years) population of the United Kingdom have evidence of peripheral arterial disease on ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ...
CHDS1: Coronary heart disease, susceptibility to, 1. *CIAPIN1: Anamorsin (originally, Cytokine induced apoptosis inhibitor 1) ... Gilbert F (1999). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 16". Genet Test. 3 (2): 243-54. ... PKDTS: Polycystic kidney disease, infantile severe, with tuberous sclerosis. *PMFBP1: encoding protein Polyamine-modulated ...
Natural history of coronary disease with and without aortocoronary by-pass operation. Survival curves of 272 patients over a ... Some diseases associated with mutations in the TATA box include gastric cancer, spinocerebellar ataxia, Huntington's disease, ... Diseases[edit]. Mutations in the TATA box region affects the binding of the TATA-binding protein (TBP) for transcription ... spinocerebellar ataxia and Huntington's disease. In spinocerebellar ataxia, the disease phenotype is caused by expansion of the ...
By this time, he was suffering from chronic coronary disease. A trip to Crimea for treatment in 1915 failed to ameliorate the ...
PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum. Reprod. Update. ... Polycystic ovarian disease: heritability and heterogeneity. Hum. Reprod. Update. 2001, 7 (1): 3-7. PMID 11212071. doi:10.1093/ ... Imaging in Polycystic Ovary Disease. eMedicine. eMedicine. 20 April 2011 [19 November 2011].. ... Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the ...
... which is the principal cause of coronary heart disease and other forms of cardiovascular disease. In contrast, HDL particles ( ... "Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention ... This disease process leads to myocardial infarction (heart attack), stroke and peripheral vascular disease. Since higher blood ... liver diseases, and mental diseases. This result indicates that the low cholesterol effect occurs even among younger ...
... coronary heart disease, dimension, osteoporosis, eye disease, stroke cancer and rheumatoid arthritis and the influence of ... coronary heart disease and strokes strong conclusive evidence of the correlation between fruit and vegetable intake and the ... The Centers for Disease Control and Prevention (2014). Children eating more fruit, but fruit and vegetable intake still too low ... Development of chronic disease has become closely related to the consumption of fruits and vegetables throughout childhood ( ...
Role in disease[edit]. Few congenital disorders of the fibrinolytic system have been documented. Nevertheless, excess levels of ... They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ... Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ... The fibrinolytic system is closely linked to control of inflammation, and plays a role in disease states associated with ...
... and coronary arteries.[8] to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 ... in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease.[citation needed] ...
Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries ... treatment or prevention of disease": 21 U.S.C. § 321(g)(1)(B).[23] However the legal position is not entirely straightforward,[ ...
... and a coronary sinus lead (red arrow). The coronary sinus lead wraps around the outside of the left ventricle, enabling pacing ... Lidwell M C, "Cardiac Disease in Relation to Anaesthesia" in Transactions of the Third Session, Australasian Medical Congress, ... sinus node disease (SND) or sick sinus syndrome. Where the problem is atrioventricular block (AVB) the pacemaker is required to ... and another passing through the vena cava and the right atrium and inserted through the coronary sinus to pace the epicardial ...
... reduction in death from coronary heart disease to a point where people are no more likely to die of coronary heart disease than ... The most common problem in FH is the development of coronary artery disease (atherosclerosis of the coronary arteries that ... However, if the person already had coronary heart disease the reduction was 25%. The results emphasize the importance of early ... June 1998). "Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and ...
Indians are at particularly high risk for atherosclerosis and coronary artery disease. This may be attributed to a genetic ... Diarrheal diseases are the primary causes of early childhood mortality. These diseases can be attributed to poor sanitation and ... Diseases such as dengue fever, hepatitis, tuberculosis, malaria and pneumonia continue to plague India due to increased ... The provision of clean drinking water and sanitation as one of the principal factors in control of diseases is well established ...
This process is undergoing pre-clinical trials in humans and may be used to treat patients suffering coronary heart disease, ... This 'Grow Your Own Arteries' technique is helping patients survive coronary heart disease, renal failure and other life- ... in heart diseases). She further determined how these cells could be maintained in the 'non-disease' phenotype. This knowledge ... definition of single transduction pathways through which factors act to enhance vascular disease regression and prevent disease ...
Soluble fiber from certain foods and risk of coronary heart disease (CHD) (revision 2015)". US Department of Health and Human ... Celiac diseaseEdit. Main articles: Oat sensitivity and Gluten-related disorders. Celiac disease (coeliac disease) is a ... Pests and diseasesEdit. Oats are relatively free from diseases and pests with the exception being leaf diseases, such as leaf ... 2009). Introduction of oats in the diet of individuals with celiac disease: a systematic review. Adv Food Nutr Res (Systematic ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... "Epidemiology of Hypertensive Kidney Disease".. CS1 maint: uses authors parameter (link). *^ Rowe, D J; Bagga, H; Betts, P B ( ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ...
... which in turn has a significant influence on the immune system and its capacity to defend the body against disease infection, ... to assess the effects of a guided imagery audiotape intervention on psychological outcomes in patients undergoing coronary ...
Best Diet for Patients With Peripheral Artery Disease Peripheral Artery Disease or PAD is a narrowing of the blood vessels - ... 2 Ways Beetroot Juice Benefits Heart Disease Patients That You May Have Not Heard Of Researchers say beetroot juice may offer ... Spontaneous coronary artery dissection - sometimes referred to as SCAD - is an uncommon emergency condition that occurs when a ... All three EUROASPIRE surveys have evaluated how patients with established cardiovascular disease, who are the top clinical ...
Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk ... Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk ... Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk ... "Our understanding of the etiology and risk factors for fatal coronary heart disease and sudden cardiac death, particularly ...
Free medicine essay example on coronary heart disease: definition and strategies to identify the risk factors on Essays ... Check Out Our Coronary Heart Disease Essay. Coronary Heart Disease Definition. Coronary heart disease can be defined as a ... In America, coronary heart disease is the leading cause of death today. In the year 2006 the coronary heart disease caused ... Coronary Heart Disease Essay Free Example. For the past 80 years in the United States, the heart disease has been a major cause ...
Read our content about coronary heart disease symptoms, which include trouble breathing, and the ways to treat it. ... FAQ: Sex and coronary heart disease Can I have sex if I have coronary heart disease? Yes, most people can continue to have a ... FAQ: Driving and coronary heart disease Can I drive a car if I have coronary heart disease? It depends on your symptoms and the ... Coronary heart disease. Coronary heart disease is a condition in which fatty substances build up in the walls of the arteries ...
Coronary heart disease (CHD) is when your coronary arteries become narrowed by a gradual build-up of fatty material within ... There are several ways you can help reduce your risk of developing coronary heart disease (CHD), such as lowering your blood ... The most common symptom of coronary heart disease (CHD) is chest pain. ... If it blocks your coronary artery and cuts off the supply of oxygen-rich blood to your heart muscle, your heart may become ...
Coronary artery disease. Synonyms. Atherosclerotic heart disease,[1] atherosclerotic vascular disease,[2] coronary heart ... Coronary artery disease (CAD), also known as ischemic heart disease (IHD),[13] refers to a group of diseases which includes ... Stable coronary artery disease (SCAD) is also often called stable ischemic heart disease (SIHD).[59] A 2015 monograph explains ... Typically, coronary artery disease occurs when part of the smooth, elastic lining inside a coronary artery (the arteries that ...
Coronary heart disease is a cardiovascular disease in which there is a failure of coronary circulation to supply adequate ... caused by a decreased capacity of the coronary vessels., Narrowing of the coronary arteries due to fatty deposits inside the ... An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood ... Coronary Artery Disease, Diseases, Coronary, CORONARY HEART DIS, Coronary Diseases, Disease, Coronary Heart, Coronary Disease, ...
Learn what causes coronary artery disease (CAD) and how it is diagnosed. Get the facts from the CDC. ... What is coronary artery disease?. Coronary artery disease (CAD) is the most common type of heart disease in the United States. ... Learn the facts about heart disease, including coronary artery disease, the most common type of heart disease. ... How is coronary artery disease diagnosed?. If youre at high risk for heart disease or already have symptoms, your doctor can ...
Coronary heart disease (CHD) is a major cause of death both in the UK and worldwide. CHD is sometimes called ischaemic heart ... Find out more about diagnosing coronary heart disease. Treating coronary heart disease (CHD). Coronary heart disease cannot be ... Causes of coronary heart disease (CHD). Coronary heart disease is the term that describes what happens when your hearts blood ... Diagnosing coronary heart disease (CHD). If your doctor feels youre at risk of CHD, they may carry out a risk assessment. ...
Coronary artery disease is the buildup of plaque on the inside of the coronary arteries, the blood vessels that supply oxygen ... depends upon how far the disease has already progressed. ... Articles OnCoronary Artery Disease. Coronary Artery Disease ... Lifestyle changes are the first step for anyone with coronary artery disease. Healthy habits can slow or even stop the disease ... Heart Disease: Should I Have Angioplasty for Stable Angina? Heart Disease: Should I Have Bypass Surgery? ...
Coronary Artery Disease Definition Coronary artery disease is a narrowing or blockage of the arteries and vessels that provide ... Coronary artery disease, also called coronary heart disease or heart disease, is the leading cause of death for both men and ... Coronary heart disease also may be called coronary artery disease or simply heart disease. It is the leading cause of death in ... Coronary artery disease, also called coronary heart disease or atherosclerotic heart disease, is the leading cause of death for ...
Health Information on Coronary Artery Disease: MedlinePlus Multiple Languages Collection ... Coronary Artery Disease: MedlinePlus Health Topic - English Enfermedad de las arterias coronarias: Tema de salud de MedlinePlus ... Coronary Artery Disease (CAD) - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF ... Coronary Artery Disease (CAD) - 繁體中文 (Chinese, Traditional (Cantonese dialect)) Bilingual PDF ...
Coronary heart disease (CHD) is also called coronary artery disease. ... Coronary heart disease is a narrowing of the small blood vessels that supply blood and oxygen to the heart. ... Heart disease, Coronary heart disease, Coronary artery disease; Arteriosclerotic heart disease; CHD; CAD ... Coronary heart disease is a narrowing of the small blood vessels that supply blood and oxygen to the heart. Coronary heart ...
Prevention of Coronary Disease. Br Med J 1969; 1 doi: https://doi.org/10.1136/bmj.1.5637.182 (Published 18 January 1969) Cite ...
Although coronary heart disease (CHD) cannot be cured, treatment can help manage the symptoms and reduce the risk of further ... Coronary angioplasty. Coronary angioplasty is also known as percutaneous coronary intervention (PCI), percutaneous transluminal ... Treatment for coronary heart disease (CHD) can help manage the symptoms and reduce the risk of further problems. ... Coronary artery bypass graft. Coronary artery bypass grafting (CABG) is also known as bypass surgery, a heart bypass, or ...
... disease characterized by an inadequate supply of oxygen-rich blood to the heart muscle (myocardium) because of narrowing or ... blocking of a coronary artery by fatty plaques (see atherosclerosis). If the oxygen depletion is extreme, the effect may be a ... ischemic heart disease. Coronary heart disease, also called coronary artery disease or ischemic heart disease, disease ... cardiovascular disease: Coronary heart disease. Coronary heart disease is a general term for a number of syndromes. Ischemic ...
Coronary artery disease describes a condition where the coronary arteries that supply the heart with oxygen and nutrients ... www.escardio.org/.../...Stable_Coronary_Artery_Disease_web_addenda.pdf. *www.nhs.uk/Conditions/Coronary-heart-disease/Pages/ ... Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are ... Coronary artery disease describes a condition where the coronary arteries that supply the heart with oxygen and nutrients ...
Coronary artery disease affects the arteries that supply the heart muscle with blood. Although it can be life-threatening, it ... Coronary artery disease (CAD) happens so often you probably know someone who has it. Its the most common type of heart disease ... Coronary artery disease (CAD) becomes more likely as you get older or if it runs in your family. But you can manage many other ... Coronary artery bypass grafting is a type of surgery in which doctors use blood vessels from other parts of your body to make a ...
This results in coronary heart disease, the most common type of heart disease in the United States. Here, we cover causes, ... The coronary arteries supply oxygen and blood to the heart. However, when cholesterol builds up on the artery walls, they can ... Coronary heart disease (CHD), or coronary artery disease, develops when the coronary arteries become too narrow. The coronary ... CHD is the most dangerous cardiovascular disease, as it causes the most deaths of any heart disease in the United States. ...
Prevention of coronary heart disease. BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7436.404-a (Published 12 February 2004 ...
... hardening and furring of the walls of the coronary arteries. ... disease is another term used for atherosclerotic heart disease ... Coronary artery disease is also often called coronary heart disease (CHD). However, CHD actually has several causes, one of ... Coronary artery disease kills millions worldwide each year. The symptoms of coronary artery disease are usually not evident ... www.escardio.org/.../...Stable_Coronary_Artery_Disease_web_addenda.pdf. *www.nhs.uk/Conditions/Coronary-heart-disease/Pages/ ...
... or coronary heart disease, can lead to heart attack or death. Learn what causes this condition and how you can prevent it. ... What is coronary artery disease?. Coronary artery disease (CAD), also called coronary heart disease, is the most common type of ... Heart disease is one type of cardiovascular disease. Per the World Health Organization (WHO). , cardiovascular diseases are the ... Tips for preventing coronary artery disease. You can make many lifestyle changes to decrease your risk of developing CAD and ...
Coronary heart disease (CHD)-also sometimes called coronary artery disease-is the most common form of cardiovascular disease, a ... Coronary heart disease (CHD)-also sometimes called coronary artery disease-is the most common form of cardiovascular disease, a ... Who Gets Coronary Heart Disease?. More than 16 million Americans suffer from CHD. Despite significant declines in the rate of ... Coronary heart disease is generally due to the buildup of plaques in the arterial walls, a process known as atherosclerosis. ...
Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... CORONARY ANGIOGRAPHY venothini My mother has small pain in below chest and back of chest, then doctor advise to go for an ... CORONARY ANGIOGRAPHY. My mother has small pain in below chest and back of chest, then doctor advise to go for an angiogram, ... 8. PDA&PLV: minimal disease Please advise us for further treatment, whether it can be cure with tablets and exercise or have to ...
Find Coronary Artery Disease information, treatments for Coronary Artery Disease and Coronary Artery Disease symptoms. ... MedHelps Coronary Artery Disease Center for Information, Symptoms, Resources, Treatments and Tools for Coronary Artery Disease ... condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or ...
Number of deaths and age-adjusted death rates* from persons within coronary heart disease† and stroke§ by sex, age, and race/ ... Continued) Number of deaths and age-adjusted death rates* from persons within coronary heart disease† and stroke§ by sex, age, ... Coronary heart disease (CHD) is the cause of more than two-thirds of all heart disease-related deaths (1,2). One of the Healthy ... Coronary heart disease and stroke deaths-United States, 2006. In: CDC. CDC health disparities and inequalities report. MMWR ...
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... Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from ... Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in ... Hybrid minimally invasive coronary artery bypass and coronary artery stent placement. Learn about minimally invasive procedures ... When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. A ...
Coronary artery disease and rheumatoid arthritis.. Goodson N1.. Author information. 1. Arthritis Research Campaign, ... It is not clear why rheumatoid patients have higher rates of coronary disease. Traditional cardiovascular risk factors do not ... It may be that these new cardiovascular risk factors are responsible for accelerating coronary heart disease in patients with ... This article reviews recent literature relating to the epidemiology of cardiovascular disease in the context of RA. ...
Extracellular vesicles in coronary artery disease.. Boulanger CM1,2, Loyer X1,2, Rautou PE1,3,4, Amabile N1,5. ... This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging ... valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease. ...
Coronary Heart Disease is plaque buildup in your arteries. Its known as hardening of the arteries, too. Arteries carry blood ... Coronary Artery Disease (CAD). Coronary artery disease is also called CAD. It is the most common form of heart disease in the U ... What is coronary heart disease?. Coronary heart disease (CHD) is the most common type of heart disease. It is also called ... What causes coronary heart disease?. Coronary heart disease develops over time. It occurs as your arteries become blocked from ...
Coronary Heart Disease Polyunsaturated Fatty Acid Fish Consumption Fish Intake Coronary Heart Disease Mortality These keywords ... Fish consumption and mortality from coronary heart disease. N.Eng.J.Med. (1985) 313, 820CrossRefGoogle Scholar ... Keys A.. Coronary heart disease in seven countries. Circulation (1970) 41, Suppl.1-1-211Google Scholar ... Coronary heart disease, serum lipids, platelets and dietary fish in two communities in Northern Norway. Acta Med.Scand. (1987) ...
Coronary artery disease (CAD) occurs when these arteries become blocked. CAD, which typically builds up over decades, is the ... most common form of heart disease and is the leading cause of heart disease-related death worldwide. ... Your coronary arteries are the large blood vessels that supply your heart muscle with oxygen-rich blood. ... Coronary Artery Disease Treatment at BIDMC. In some cases, coronary artery disease can be managed with lifestyle changes aimed ...
CHD is sometimes called ischaemic heart disease. Dial 999 for immediate medical help if you think youre having a heart attack ... Coronary heart disease (CHD) is a major cause of death both in Northern Ireland and worldwide. ... coronary angiography. Treating coronary heart disease. Coronary heart disease cant be cured. But treatment can help manage the ... Coronary heart disease. Coronary heart disease (CHD) is a major cause of death both in Northern Ireland and worldwide. CHD is ...
Prevalence of Subclinical Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography in 45- to 55-Year-Old ... of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease Ankur ... of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Patients With Stable Coronary Artery DiseaseThree-Year ... Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest ...
  • CONCLUSIONS: Numerous family history variables in addition to early-onset coronary heart disease are associated with subclinical atherosclerosis. (rand.org)
  • The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. (emaxhealth.com)
  • This third EUROASPIRE survey has evaluated how effectively these recommendations have been implemented in daily practice in relation to the standards set in the Third Joint European Task Force guidelines on cardiovascular disease prevention in 2003. (emaxhealth.com)
  • All three EUROASPIRE surveys have evaluated how patients with established cardiovascular disease, who are the top clinical priority, are being managed, but in this third survey, the second priority group of asymptomatic individuals who are at high risk of developing cardiovascular disease have been addressed. (emaxhealth.com)
  • These lifestyle and risk factor results clearly demonstrate a challenging gap between what is recommended in the guidelines based on scientific evidence and what is achieved in daily practice in high risk individuals in primary prevention of cardiovascular disease. (emaxhealth.com)
  • The association between magnesium and a reduced risk for cardiovascular disease was attenuated in the fully adjusted model, with an HR of 1.19 (95% CI, 1.06-1.34) for CHD and an HR of 1.24 (95% CI, 0.58-2.65) for SCD among women in the lowest quartile of magnesium intake. (healio.com)
  • METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. (ku.dk)
  • Primary prevention of heart disease needs a comprehensive, multidisciplinary approach involving the high-risk population, their GP's and other health professionals, a health insurance system dedicated to prevention and all this complemented by a population strategy involving the community at large. (emaxhealth.com)
  • Associations between family history of coronary heart disease and coronary artery calcium score were significant regardless of age at onset, sex, lineage, or number of relatives with coronary heart disease. (rand.org)
  • This uses magnets and radio waves to produce images of the inside of your body to examine your heart for signs of coronary heart disease. (bupa.co.uk)
  • RESULTS: Family history of coronary heart disease alone and in combination with diabetes and/or stroke was significantly associated with a positive coronary artery calcium score compared with no family history with odds ratios ranging from 1.7 (95% CI: 1.3-2.3) to 1.9 (95% CI: 1.6-2.3) and adjusted mean coronary artery calcium score estimates ranging from 137 (95% CI: 101-173) to 184 (95% CI: 143-226). (rand.org)
  • Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. (elsevier.com)
  • PURPOSE: To investigate the possibility that family history beyond early-onset coronary heart disease might contribute to coronary heart disease susceptibility, the authors studied associations between additional family history and the coronary artery calcium score. (rand.org)
  • Clinical Infectious Diseases , 45 (8), 1074-1081. (elsevier.com)
  • In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. (emoryhealthcare.org)
  • Bernie Sanders, independent candidate of Vermont, was rushed into surgery for a blocked coronary artery after he experienced chest pains during a campaign event on Tuesday. (sandrarose.com)
  • A number of tests may help with diagnoses including: electrocardiogram, cardiac stress testing, coronary computed tomographic angiography, and coronary angiogram, among others. (wikipedia.org)
  • Identifying and treating plaque buildup and other intravascular conditions could reduce the morbidity and mortality rates from coronary artery disease," he said. (purdue.edu)
  • The cause of coronary artery disease is almost always atherosclerotic plaque-gooey cholesterol-filled deposits that form inside artery walls. (harvard.edu)
  • Comparative pathologic study.Natural history of the human coronary atherosclerotic plaque and related forms of myocardial injuries.Findings in acute coronary syndromes.Revisiting dogma related to coronary artery disease.Adrenergic stress. (routledge.com)
  • Von Birgelen states that this additional information is important for assessing disease progression - plaque progression. (innovations-report.com)
  • Prevalence of type 2 diabetes in Asia seems to be almost epidemic and establishment of preventive strategy against macrovascular as well as microvascular diseases are warranted because of higher cardiovascular risk in diabetic patients even without history of atherosclerotic cardiovascular diseases. (centerwatch.com)
  • The implant device is designed to continuously monitor the electrocardiogram signal and detect ST shifts that could be indicative of a blockage of a coronary artery. (centerwatch.com)
  • books.google.com - One of the leading experts in the field and a stellar cast of contributors provide all of the scientific and clinical information needed to facilitate rapid evaluation and immediate management of acute coronary syndromes using today's full range of strategies-from pharmaceutical approaches to revascularization. (google.com)
  • Management of Acute Coronary Syndromes is the most up to date and comprehensive evidence-based guide to managing acute coronary syndromes, in a compact and usable format. (wiley.com)
  • Clinical observations have documented substantial differences in the extent of collateralization among patients with coronary artery disease (CAD), with some individuals demonstrating marked abundance and others showing nearly complete absence of these vessels. (ahajournals.org)
  • Coronary artery bypass surgery (also known as coronary artery bypass grafting) or angioplasty may be necessary if medications and diet and lifestyle changes, such as frequent exercise and cessation of smoking, are not effective. (britannica.com)
  • Meta-analysis of randomised trials comparing coronary angioplasty with bypass surgery. (springer.com)
  • Burgeoning dilemmas in the management of diabetes and cardiovascular disease: rationale for the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial. (springer.com)
  • The FDA's approval of the Absorb GT1 BVS offers a new treatment option for individuals who are candidates for angioplasty, but would prefer an absorbable device rather than a permanent metallic coronary stent," said Bram Zuckerman, M.D., director of the division of cardiovascular devices at the FDA's Center for Devices and Radiological Health. (fda.gov)
  • Boston now boasts a hospital where robots have joined doctors to offer minimally invasive coronary artery bypass graft surgery to patients with severe blockages. (medindia.net)
  • Two recent prospective epidemiologic studies, the Pittsburgh Epidemiology of Diabetes Complications (EDC) study ( 6 ) and Eurodiab ( 7 ), a multicenter, clinic-based study in Europe, confirmed these earlier reports and reported an incidence of total coronary events (including electrocardiogram [ECG] changes) of 16% over 10 years and 9% over 7 years, respectively, of follow-up in type 1 diabetic patients. (diabetesjournals.org)
  • Optical imaging technology from Wasatch Photonics Inc. creates images of coronary artery walls in vivo to show where lesions and plaques have formed. (purdue.edu)
  • Cardiologists work together with a multidisciplinary team of doctors in other medical specialties to diagnose and treat people with conditions such as carotid artery disease or peripheral artery disease who may need catheter-based forms of therapy. (mayoclinic.org)
  • Importantly, DM is a key risk factor for the development of chronic kidney disease (CKD), which further enhances atherothrombotic risk. (centerwatch.com)
  • M. Annuk, M. Zilmer, and B. Fellström, "Endothelium-dependent vasodilation and oxidative stress in chronic renal failure: impact on cardiovascular disease," Kidney International , vol. 84, pp. (hindawi.com)
  • It is true that the majority of chronic disease care in Canada (such as management of coronary artery disease) occurs in primary care and that there is room for improvement in how we manage these patients. (cmaj.ca)
  • Gaining more than five pounds by middle age increases risk for chronic disease and earlier death, finds study. (cardiosmart.org)