An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The circulation of blood through the CORONARY VESSELS of the HEART.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Narrowing or constriction of a coronary artery.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Spasm of the large- or medium-sized coronary arteries.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Elements of limited time intervals, contributing to particular results or situations.
Pathologic deposition of calcium salts in tissues.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A glutamate plasma membrane transporter protein that is primarily expressed in the RETINA.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The hollow, muscular organ that maintains the circulation of the blood.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Drugs used to cause dilation of the blood vessels.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Radiography of the heart and great vessels after injection of a contrast medium.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The return of a sign, symptom, or disease after a remission.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Substances used to lower plasma CHOLESTEROL levels.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Hospital equipment and supplies, packaged for long-term storage, sufficient to set up a general hospital in an emergency situation. They are also called Packaged Disaster Hospitals and formerly Civil Defense Emergency Hospitals.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A characteristic symptom complex.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Research techniques that focus on study designs and data gathering methods in human and animal populations.
Inhaling and exhaling the smoke of burning TOBACCO.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The transference of a heart from one human or animal to another.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
7-carbon saturated monocarboxylic acids.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Disease having a short and relatively severe course.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Contractile activity of the MYOCARDIUM.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Radiography of blood vessels after injection of a contrast medium.
Obstruction of flow in biological or prosthetic vascular grafts.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The prevention of recurrences or exacerbations of a disease or complications of its therapy.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Formation and development of a thrombus or blood clot in the blood vessel.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Lesions formed within the walls of ARTERIES.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Conditions with excess LIPIDS in the blood.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Therapy with two or more separate preparations given for a combined effect.
Unstable isotopes of rubidium that decay or disintegrate emitting radiation. Rb atoms with atomic weights 79-84, and 86-95 are radioactive rubidium isotopes.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Individuals whose ancestral origins are in the continent of Europe.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
A species in the genus GARDNERELLA previously classified as Haemophilus vaginalis. This bacterium, also isolated from the female genital tract of healthy women, is implicated in the cause of bacterial vaginosis (VAGINOSIS, BACTERIAL).
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
Motion pictures of the passage of contrast medium through blood vessels.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
The main trunk of the systemic arteries.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.

Anti-heart autoantibodies in ischaemic heart disease patients. (1/12062)

One hundred and ninety-nine ischaemic heart disease (IHD) patients were studied with regard to the prevalence of anti-heart autoantibodies (AHA). The incidence of AHA in IHD patients was 1%: one out of 102 patients who suffered acute myocardial infarction (AMI), one out of seventy-two patients who suffered from acute coronary insufficiency (ACI), and none out of twenty-five patients with other signs and symptoms of IHD, had AHA in their sera. An additional 2% of patients who suffered from AMI developed detectable antibody levels during a follow-up period of 15 days. In comparison,, 53% of patients (eight out of fifteen) who underwent heart surgery and who had no AHA prior to operation, developed these antibodies in their sera during 1-2 weeks following operation.  (+info)

Comparative total mortality in 25 years in Italian and Greek middle aged rural men. (2/12062)

STUDY OBJECTIVE: Mortality over 25 years has been low in the Italian and very low in the Greek cohorts of the Seven Countries Study; factors responsible for this particularity were studied in detail. PARTICIPANTS AND SETTINGS: 1712 Italian and 1215 Greek men, aged 40-59 years, cohorts of the Seven Countries Study, representing over 95% of the populations in designated rural areas. DESIGN: Entry (1960-61) data included age, systolic blood pressure (SBP), smoking habits, total serum cholesterol, body mass index (BMI), arm circumference, vital capacity (VC), and forced expiratory volume in 3/4 seconds (FEV); the same data were obtained 10 years later. Multivariate Cox analysis was performed with all causes death in 25 years as end point. MAIN RESULTS: Italian men had higher entry levels of SBP, arm circumference, BMI, and VC; Greek men had higher cholesterol levels, smoking habits, and FEV. Mortality of Italian men was higher throughout; at 25 years cumulative mortality was 48.3% and 35.3% respectively. Coronary heart disease and stroke mortality increased fivefold in Italy and 10-fold in Greece between years 10 and 25. The only risk factor with a significantly higher contribution to mortality in Italian men was cholesterol. However, differences in entry SBP (higher in Italy) and FEV (higher in Greece) accounted for, according to the Lee method, 75% of the differential mortality between the two populations. At 10 years increases in SBP, cholesterol, BMI, and decreases in smoking habits, VC, FEV, and arm circumference had occurred (deltas). SBP increased more and FEV and VC decreased more in Italy than in Greece. Deltas, fed stepwise in the original model for the prediction of 10 to 25 years mortality, were significant for SBP, smoking, arm circumference, and VC in Greece, and for SBP and VC in Italy. CONCLUSION: Higher mortality in Italian men is related to stronger positive effects of entry SBP and weaker negative (protective) effects of FEV; in addition 10 year increases in SBP are higher and 10 year decreases in FEV are larger in Italy. Unaccounted factors, however, related to, for example, differences in the diet, may also have contributed to the differential mortality of these two Mediterranean populations.  (+info)

Is hospital care involved in inequalities in coronary heart disease mortality? Results from the French WHO-MONICA Project in men aged 30-64. (3/12062)

OBJECTIVES: The goal of the study was to assess whether possible disparities in coronary heart disease (CHD) management between occupational categories (OC) in men might be observed and contribute to the increasing inequalities in CHD morbidity and mortality reported in France. METHODS: The data from the three registers of the French MONICA Collaborative Centres (MCC-Lille, MCC-Strasbourg, and MCC-Toulouse) were analysed during two period: 1985-87 and 1989-91. Acute myocardial infarctions and coronary deaths concerning men, aged 30-64 years, were included. Non-professionally active and retired men were excluded. Results were adjusted for age and MCC, using a logistic regression analysis. RESULTS: 605 and 695 events were analysed for 1985-87 and 1989-91, respectively. Out of hospital cardiac arrests, with or without cardiac resuscitation, and 28 day case fatality rates were lower among upper executives in both periods. A coronarography before the acute event had been performed more frequently in men of this category and the proportion of events that could be hospitalised was higher among them. In both periods, the management of acute myocardial infarctions in hospital and prescriptions on discharge were similar among occupational categories. CONCLUSIONS: For patients who could be admitted to hospital, the management was found to be similar among OCs, as was the 28 day case fatality rate among the hospitalised patients. In contrast, lower prognosis and higher probability of being hospitalised after the event among some categories suggest that pre-hospital care and the patient's conditions before the event are the primary factors involved.  (+info)

Short stature and cardiovascular disease among men and women from two southeastern New England communities. (4/12062)

BACKGROUND: Short stature has been associated with an increased risk of coronary heart disease (CHD), although the reason for the association remains unclear. Data on the relation between stature and stroke is more limited. We examined the association between stature and CHD as well as between stature and stroke in men and women from two communities in southeastern New England. METHODS: Coronary heart disease and stroke events were abstracted from medical records between January 1980 and December 1991. An epidemiological diagnostic algorithm developed to measure CHD was used in the present analysis. Unadjusted relative risks (RR) and RR adjusted for age, smoking status, obesity, high-density lipoprotein (HDL) cholesterol <0.91 mmol/l, total cholesterol >6.21 mmol/l, hypertension, diabetes, education, and being foreign born were computed by gender-specific height categories separately for men (n = 2826) and women (n = 3741). RESULTS: A graded inverse association between stature and risk of CHD was observed among men which persisted after adjustment for confounders. Men >69.75 inches had an 83% lower risk of CHD compared with men < or = 65 inches. In addition, the tallest men had a 67% decreased risk of stroke compared with the shortest men. No significant relation between stature and CHD or stroke was observed among women. CONCLUSIONS: These data support the hypothesis that stature is inversely related to both risk of CHD and stroke at least among men. Factors which might explain this association remain to be determined.  (+info)

Natural sporting ability and predisposition to cardiovascular disorders. (5/12062)

We tested the hypothesis that people with a natural ability in 'power sports' (a presumed marker for predominance of type 2, glycolytic muscle fibres) might have increased risks of coronary heart disease (CHD) compared to those with a natural ability in 'endurance sports' (as a marker for predominance of type 1, oxidative muscle fibres). We examined subsequent cardiovascular disorders retrospectively in 231 male former soldiers, aged 34-87 years, who had undergone a course in physical training in the Army School of Physical Training, Aldershot, UK, who assessed themselves as having natural ability in either power (n = 107) or endurance (n = 124) sports. The proportion with CHD, defined as angina and/or coronary angioplasty and/or coronary artery bypass graft and/or heart attack was 18.7% in the 'power group' vs. 9.7% in the 'endurance group' (difference: chi 2 = 3.9, p = 0.05). The proportions with CHD and/or risk factors rose to 39.3% in the 'power group' vs. 25.8% in the 'endurance group' (difference: chi 2 = 4.8, p = 0.03). Under logistic regression analysis, compared to the 'endurance group', the 'power group' had 2.2 (95% CI: 1.00-4.63) the risk of developing CHD, and 1.86 (95% confidence interval: 1.06 to 3.25) the risk of developing CHD and/or risk factors. Men with a natural ability in 'power sports' are at increased risk of developing cardiovascular disorders, compared to men with a natural ability in 'endurance sports'. A predominance of type 2, glycolytic muscle fibres, presumably of genetic origin, may predispose to cardiovascular disorders.  (+info)

The PRIME study: classical risk factors do not explain the severalfold differences in risk of coronary heart disease between France and Northern Ireland. Prospective Epidemiological Study of Myocardial Infarction. (6/12062)

We are studying the contribution of risk and genetic factors, and their interaction, to the development of ischaemic heart disease (IHD) and other cardiovascular endpoints. The study is prospective, based in three centres in the south, east and north of France and in Northern Ireland. A total of 10,592 men aged 50-59 years were recruited from 1991 to 1993, and examined for evidence of IHD at baseline. Subjects are followed annually by questionnaire. Clinical information is validated from hospital and GP records. Demographic characteristics were similar in all four centres. Body mass index was highest in Strasbourg (mean 27.4 kg/m2 vs. 26.3 kg/m2 in Toulouse and Belfast), but total cholesterol, triglyceride and fibrinogen were highest in Belfast. In Belfast, 6.1% reported having had a coronary angiogram, compared to 3.0% in Toulouse. Conversely, 13.8% in Toulouse reported taking lipid-lowering drugs vs. 1.6% in Belfast. As predicted, a history of myocardial infarction (MI) was highest in Belfast (6.1%) and lowest in Toulouse (1.2%). Some 7.1% of Belfast men reported a medical diagnosis of angina vs. 1.5% in Toulouse. Subjects showing evidence of pre-existing IHD will be studied prospectively but treated in the analysis as an additional variable. These results provide a measure of reassurance that these cohorts are representative of the communities from which they are drawn and provide a reliable baseline for prospective evaluation and cross-sectional comparisons. The levels of the classical risk factors found in this study, particularly when examined in combination, as multiple logistic functions based on previous British studies, are very similar between centres and cannot explain the large differences in the incidence of IHD which exist. Additional risk factors may help explain, at least in part, the major differences in incidence of IHD between these study centres.  (+info)

Chlamydia pneumoniae and atherosclerosis. (7/12062)

OBJECTIVE: To review the literature for evidence that chronic infection with Chlamydia pneumoniae is associated with atherosclerosis and acute coronary syndromes. DATA SOURCES: MEDLINE and Institute of Science and Information bibliographic databases were searched at the end of September 1998. Indexing terms used were chlamydi*, heart, coronary, and atherosclerosis. Serological and pathological studies published as papers in any language since 1988 or abstracts since 1997 were selected. DATA EXTRACTION: It was assumed that chronic C pneumoniae infection is characterised by the presence of both specific IgG and IgA, and serological studies were examined for associations that fulfilled these criteria. Pathological studies were also reviewed for evidence that the presence of C pneumoniae in diseased vessels is associated with the severity and extent of atherosclerosis. DATA SYNTHESIS: The majority of serological studies have shown an association between C pneumoniae and atherosclerosis. However, the number of cases in studies that have reported a positive association when using strict criteria for chronic infection is similar to the number of cases in studies which found no association. Nevertheless, the organism is widely found in atherosclerotic vessels, although it may not be at all diseased sites and is not confined to the most severe lesions. Rabbit models and preliminary antibiotic trials suggest that the organism might exacerbate atherosclerosis. CONCLUSION: More evidence is required before C pneumoniae can be accepted as playing a role in atherosclerosis. Although use of antibiotics in routine practice is not justified, large scale trials in progress will help to elucidate the role of C pneumoniae.  (+info)

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (8/12062)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

TY - JOUR. T1 - Explaining the decline in coronary heart disease mortality rates in Japan. T2 - Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. AU - Ogata, Soshiro. AU - Nishimura, Kunihiro. AU - Guzman-Castillo, Maria. AU - Sumita, Yoko. AU - Nakai, Michikazu. AU - Nakao, Yoko M.. AU - Nishi, Nobuo. AU - Noguchi, Teruo. AU - Sekikawa, Akira. AU - Saito, Yoshihiko. AU - Watanabe, Taeko. AU - Kobayashi, Yasuki. AU - Okamura, Tomonori. AU - Ogawa, Hisao. AU - Yasuda, Satoshi. AU - Miyamoto, Yoshihiro. AU - Capewell, Simon. AU - OFlaherty, Martin. PY - 2019/9/15. Y1 - 2019/9/15. N2 - Background: We aimed to quantify contributions of changes in risks and uptake of evidence-based treatment to coronary heart disease (CHD) mortality trends in Japan between 1980 and 2012. Methods: We conducted a modelling study for the general population of Japan aged 35 to 84 years using the validated IMPACT model incorporating data sources like Vital Statistics. The main ...
TY - JOUR. T1 - Self-Reported Health and Outcomes in Patients With Stable Coronary Heart Disease. AU - Stewart, Ralph. AU - Hagstrom, Emil. AU - Held, Claes. AU - Wang, Tom. AU - Armstrong, Paul. AU - Aylward, Philip. AU - Cannon, Christopher. AU - Koenig, Wolfgang. AU - Lopez-Sendon, Jose. AU - Mohler III, Emile. AU - Hadziosmanovic, Nermin. AU - Krug-Gourley, Susan. AU - Ramos-Corrales, Marco. AU - Siddique, Saulat. AU - Steg, Philippe. AU - White, Harvey. AU - Wallentin, Lars. PY - 2017. Y1 - 2017. N2 - Background--The major determinants and prognostic importance of self-reported health in patients with stable coronary heart disease are uncertain. Methods and Results--The STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial randomized 15 828 patients with stable coronary heart disease to treatment with darapladib or placebo. At baseline, 98% of participants completed a questionnaire that included the question, Overall, how do you feel your general ...
TY - JOUR. T1 - Progression of coronary calcium and incident coronary heart disease events. T2 - MESA (Multi-Ethnic Study of Atherosclerosis). AU - Budoff, Matthew J.. AU - Young, Rebekah. AU - Lopez, Victor A.. AU - A. Kronmal, Richard. AU - Nasir, Khurram. AU - Blumenthal, Roger S.. AU - Detrano, Robert C.. AU - Bild, Diane E.. AU - Guerci, Alan D.. AU - Liu, Kiang. AU - Shea, Steven. AU - Szklo, Moyses. AU - Post, Wendy. AU - Lima, Joao. AU - Bertoni, Alain. AU - Wong, Nathan D.. PY - 2013/3/26. Y1 - 2013/3/26. N2 - Objectives: The study examined whether progression of coronary artery calcium (CAC) is a predictor of future coronary heart disease (CHD) events. Background: CAC predicts CHD events and serial measurement of CAC has been proposed to evaluate atherosclerosis progression. Methods: We studied 6,778 persons (52.8% female) aged 45 to 84 years from the MESA (Multi-Ethnic Study of Atherosclerosis) study. A total of 5,682 persons had baseline and follow-up CAC scans approximately 2.5 ± ...
Stressful Life Events and Coronary Heart Disease Patients, 978-613-8-23434-0, Psychological factors play a very important role in the existence and formation of Heart diseases, especially Coronary Heart Disease (CHD). Nowadays, heart diseases especially CHD which its clinical spectrum varies from silence ischemia to stable angina, unstable angina, myocardial infection and sudden heart death is one of the three main causes of death in the industrial countries besides cancer and brain stroke. Fifty million people die annually around the world; 12 million of them die because of cardiovascular diseases.Stress can affect persons health through behavioral and physiologic changes. Stress can also lead to heart diseases through psychological changes. It seems that stress has direct effects on coronary arteries and heart muscles. Nontraditional risk factors, such as psychological traits, have been increasingly recognized as important contributors to the genesis and outcomes of coronary artery disease. Mental
Indices of socio-economic deprivation are often used as a proxy for differences in the health behaviours of populations within small areas, but these indices are a measure of the economic environment rather than the health environment. Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of unhealthy lifestyle. Multi-level regression models showed that this index described about 50% of the large-scale geographic variation in CHD mortality rates in England, and substantially adds to the ability of an index of deprivation to explain geographic variations in CHD mortality rates.
The Stanford Five-City Project was initiated in 1978 to evaluate the effects of community-wide health education on coronary heart disease risk factors in two control San Luis Obispo and Modesto and two treatment Monterey and Salinas cities. This paper examines sex differences in the prevalence of smoking, hypercholesterolemia, and hypertension...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated risk for cardiovascular disease. Eligible patients will be randomized to receive either dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary, guidelines-based medical care. Anticipated time on study treatment is 4 years ...
Abstract: Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation, has been widely used for treatment of coronary heart disease (CHD) in China. However, the active constituents of XKS and their interactions with targets remain unclear. In this study, we assessed two docking programs, LibDock and AutoDock, by calculating the root-mean-square deviation (RMSD) of X-ray structure reproduction and the enrichment factor (EF) in virtual screening; both proved to be practical in our protein-ligand complex systems. Moreover, the combined use of the two programs yielded better EFs for each target. We therefore used a combination of the two programs to investigate the interactions of the 51 chemical constituents identified from XKS with five CHD targets, namely peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2), and thrombin. The docking results suggest that pueroside A, pueroside ...
heartdiseasehotline - informative website on coronary heart disease, congential heart disease, heart disease women, rheumatic heart disease, heart disease prevention, heart disease risk (archive ID #3) - Read it at
heartdiseasehotline - informative website on coronary heart disease, congential heart disease, heart disease women, rheumatic heart disease, heart disease prevention, heart disease risk - Read it at
Coronary heart disease currently affects more than 7 million Americans, making it the most common form of heart disease. Men initially have a greater risk for developing coronary heart disease than women do. Once a woman reaches menopause however, her risk for heart disease eventually equals or surpasses that of a man. Experts believe this may be due in part to a decrease in the production of estrogen, a female sex hormone that appears to offer some protection against heart disease.. Coronary heart disease remains the number one cause of death for both women and men in the US, accounting for more than 500,000 deaths from heart attacks each year. Experts agree that many of these deaths can be prevented by changes in lifestyle, which when implemented, can directly reduce your chances for developing coronary heart disease.. Risk factors for coronary heart disease are circumstances or conditions that increase the likelihood of your developing this disease. Risk factors are generally divided into two ...
Heart disease is the number one killer in the United States (American Heart Association, 2005). The purpose of this study was to demonstrate the results of a twelve-week exercise program on coronary heart disease risk factors in full-time hospital employees. Methods: The participants were given cardiovascular, weight training, and flexibility recommendations to follow during a twelve-week period. The main heart disease risk factors measured before and after the completion of the exercise program were blood pressure, total cholesterol, HDL-cholesterol, and body mass index. The information was put into the Framingham Heart Score to estimate the participants 10-year risk of developing heart disease. Other factors measured to show the benefits of exercise included resting heart rate, weight, body fat percentage, waist and hip ratio, maximal oxygen uptake (VO2), and flexibility. Results: There were no significant results from any measurements taken.
BACKGROUND Adult height has been inversely associated with coronary heart disease risk in several studies. The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study. METHODS All men aged 45-59 years living in the town of Caerphilly, South Wales were approached, and 2512 (89%) responded and underwent a detailed examination, which included measurement of height and sitting height (from which an estimate of leg length was derived). Participants were followed up through repeat examinations and the cumulative incidence of coronary heart disease-both fatal and non-fatal-over a 15 year follow up period is the end point in this report. RESULTS Cross sectional associations between cardiovascular risk factors and components of stature (total height, leg length and trunk length) demonstrated that factors related to the insulin resistance ...
Results:. Study 1: 10-year cardiovascular mortality was significantly and linearly associated with glycemic control (fasting blood glucose and glycated hemoglobin A1 levels) independently of the mode of treatment. A high fasting blood glucose level significantly predicted cardiovascular mortality in multiple logistic regression analysis independently of other risk factors. Study 2: Glycated hemoglobin A1c was the most important single risk factor associated with coronary heart disease death or all coronary heart disease events. In multiple logistic regression analysis, glycated hemoglobin A1c was significantly associated with coronary heart disease death after adjustment for other cardiovascular risk factors. ...
Higher magnesium intake was linked to a statistically significant risk reduction in fatal coronary heart disease and a risk reduction for sudden cardiac death among postmenopausal women, according to an analysis published in the Journal of Women’s Health.“Our understanding of the etiology and risk factors for fatal coronary heart disease and sudden cardiac death, particularly among
TY - JOUR. T1 - Ten-year predicted coronary heart disease risk in HIV-infected men and women. AU - Kaplan, Robert C.. AU - Kingsley, Lawrence A.. AU - Sharrett, A. Richey. AU - Li, Xiuhong. AU - Lazar, Jason. AU - Tien, Phyllis C.. AU - Mack, Wendy J.. AU - Cohen, Mardge H.. AU - Jacobson, Lisa. AU - Gange, Stephen J.. PY - 2007/10/22. Y1 - 2007/10/22. N2 - Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among ...
Of the 41 438 participants in the cohort, we excluded the following from the analyses: 193 for having coronary heart disease at baseline; 167 for an implausibly high or low dietary consumption, defined as 3 standard deviations either way from the cohort mean (,788 kcal/day or ,5710 kcal/day); and 321 for lacking data on important variables such as date of coronary heart disease event (n=12), smoking (n=22), diabetes mellitus (n=71), hypercholesterolaemia (n=197), and hypertension (n=60). Thus the analyses were carried out on 40 757 participants.. We used Cox regression to obtain hazard ratios for coronary heart disease according to sex specific quarters of fried food consumption. The quarter (first) with lowest consumption was used as reference. In the Cox models, age was the underlying time variable, with entry time defined as the participants age at recruitment and exit time as the age at the coronary heart disease event, death, or 31 December 2004, whichever came first. To reduce violations ...
Results. Both middle-aged and elderly men with T wave amplitudes ≥0.15 mV had a lower risk of myocardial infarction, coronary heart disease death and sudden death than men with T wave amplitudes 0.05 to 0.15 mV. The adjusted relative risk of coronary heart disease death was 0.5 (95% confidence interval [CI] 0.2 to 1.0); in men with T wave amplitude ≤0.05 mV, relative risk was 2.0 (95% CI 1.3 to 3.1). Slight ST segment elevation was also associated with decreased risk: relative risk 0.5 (95% CI 0.3 to 1.0) compared with the isoelectric ST segment level. In men with ST segment depression, relative risk was 2.2 (95% CI 1.4 to 3.4). The associations of T wave amplitude and ST segment level were independent of each other. ...
I dont know what to make of this new study. Background...
I dont like Mondays---day of the week of coronary heart disease deaths in Scotland: study of routinely collected data Academic Article ...
In a prospective study of over 17 000 civil servants followed up for 25 years, there was an inverse association between SES and CHD mortality in participants with and without prevalent CHD at baseline.. The inverse social gradient in CHD mortality could be a result of increased incidence (aetiology), case fatality (prognosis) or both among those of lower SES. Case fatality includes both survival of an acute event, such as myocardial infarction, and prognosis in chronic manifestations of CHD, such as angina. We studied the latter-established CHD in a working population- and found a significant effect of SES on CHD mortality among those with prevalent CHD defined by symptomatic status. When prevalent CHD was defined by Q, ST or T abnormality in the absence of symptoms, the SES effect was similar but the confidence intervals spanned unity. Participants with both symptoms and ECG abnormality were at very high risk (relative to those without symptoms or any ECG abnormality) and in this group there ...
TY - JOUR. T1 - Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. AU - Chambless, Lloyd E.. AU - Folsom, Aaron R.. AU - Sharrett, A. Richey. AU - Sorlie, Paul. AU - Couper, David. AU - Szklo, Moyses. AU - Nieto, F. Javier. PY - 2003/9/1. Y1 - 2003/9/1. N2 - Risk prediction functions for incident coronary heart disease (CHD) were estimated using data from the Atherosclerosis Risk in Communities (ARIC) Study, a prospective study of CHD in 15,792 persons recruited in 1987-1989 from four U.S. communities, with follow-up through 1998. Predictivity of which individuals had incident CHD was assessed by increase in area under ROC curves resulting from adding nontraditional risk factors and markers of subclinical disease to a basic model containing only traditional risk factors. We also assessed the increase in population attributable risk. The additional factors were body mass index; waist-hip ratio; sport activity index; forced expiratory volume; plasma ...
Doug Manuel, MD, MSc, William M. Flanagan, BM, Meltem Tuna, PhD, Anya Okhmatovskaia, PhD, Philippe Finès, PhD; Carol Bennett, MSc. Coronary heart disease risk factors in Canada: a Microsimulation predictive model. Simulated Technology for Applied Research (STAR). Slideshow 3725048 by cicero
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TY - JOUR. T1 - Value of genetic testing in the prevention of coronary heart disease events. AU - Hynninen, Yrjänä. AU - Linna, Miika. AU - Vilkkumaa, Eeva. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: The health economic evidence about the value and optimal targeting of genetic testing in the prevention of coronary heart disease (CHD) events has remained limited and ambiguous. The objective of this study is to optimize the population-level use and targeting of genetic testing alongside traditional risk factors in the prevention of CHD events and, thereby, to assess the cost-benefit of genetic testing. Methods and findings: We compare several strategies for using traditional and genetic testing in the prevention of CHD through statin therapy. The targeting of tests to different patient segments within these strategies is optimized by using a decision-analytic model, in which a patients estimated risk of CHD is updated based on test results using Bayesian methods. We adopt the perspective of ...
TY - JOUR. T1 - Consensus on. T2 - Screening and therapy of coronary heart disease in diabetic patients. AU - Rivellese, A. A.. AU - Piatti, P. M.. PY - 2011/10. Y1 - 2011/10. N2 - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason the main Italian scientific societies dealing with diabetes and cardiovascular diseases have tried to finalize a document providing shared recommendations based on the available evidence on: 1) how and who to screen for coronary heart disease, 2) methodologies for the characterization of existing coronary heart disease 3) evaluation of the optimal treatment of cardiovascular risk factors and 4) appropriate revascularization procedures. For each of these points, the levels of evidence and strength of recommendations used in the Italian Standard of Care were adopted.. AB - The screening and best treatment for coronary heart disease in diabetic patients is still a matter of debate. For this reason ...
TY - JOUR. T1 - Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke. T2 - A pooled analysis of 97 prospective cohorts with 1·8 million participants. AU - The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects). AU - Lu, Yuan. AU - Hajifathalian, Kaveh. AU - Ezzati, Majid. AU - Woodward, Mark. AU - Rimm, Eric B.. AU - Danaei, Goodarz. AU - Selmer, Randi. AU - Strand, Bjorn H.. AU - Dobson, A.. AU - Hozawa, A.. AU - Nozaki, A.. AU - Okayama, Akira. AU - Rodgers, A.. AU - Tamakoshi, A.. AU - Zhou, B. F.. AU - Zhou, B.. AU - Yao, C. H.. AU - Jiang, C. Q.. AU - Gu, D. F.. AU - Heng, D.. AU - Giles, Graham G.. AU - Shan, G. L.. AU - Whitlock, G.. AU - Arima, H.. AU - Kim, H. C.. AU - Christensen, H.. AU - Horibe, H.. AU - Maegawa, H.. AU - Tanaka, H.. AU - Ueshima, Hirotsugu. AU - Zhang, H. Y.. AU - Kim, I. S.. AU - Suh, I.. AU - Fuh, J. L.. AU - Lee, J.. AU - Woo, Jean. AU - Xie, J. ...
Objectives. We attempted to determine whether elevated levels of the classic coronary heart disease risk factors are associated with increased coronary risk and all-cause mortality among elderly men with and without coronary heart disease at baseline. Methods. The classic coronary risk factor levels and risk of coronary events and total...
Since it is changing into a typical medical malady, it is necessary to concentrate on the risk factors for coronary heart disease. There are a variety of irregular conditions that have an effect on the guts and the vessels supplying the heart with blood. Coronary heart disease is the foremost widespread quite heart problem. Its additionally the foremost common reason for heart attacks.. Injury that occurs to the center when the supply of blood is reduced is known as coronary heart disease. What normally happens is, deposits that are fatty in nature, build up among the liner of blood vessels whose job its to supply blood to the guts muscles. This causes narrowing of the blood vessels and the ensuing issue could be a reduction within the blood provide to the heart muscles. This causes symptoms of pain called angina.. Causes of Coronary Heart Disease. There are risk factors for coronary heart disease that are thought of to be responsible for this disease. The most important and most well-known ...
BackgroundCurrent guidelines do not recommend routine cardiac stress testing in patients with stable coronary heart disease (CHD) unless they report symptoms of
TY - JOUR. T1 - More on coronary heart disease. T2 - The dietary sense and nonsense [3]. AU - Holmqvist, O. H.. AU - Bassler, T. J.. AU - Enig, M. G.. AU - Stone, N. J.. PY - 1994/1/1. Y1 - 1994/1/1. UR - UR - U2 - 10.1056/NEJM199409013310913. DO - 10.1056/NEJM199409013310913. M3 - Letter. C2 - 8047096. AN - SCOPUS:1642500224. VL - 331. SP - 614. EP - 616. JO - New England Journal of Medicine. JF - New England Journal of Medicine. SN - 0028-4793. IS - 9. ER - ...
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Flint, A.J., et al. (2010) Excess Weight and the Risk of Incident Coronary Heart Disease among Men and Women. Obesity (Silver Spring, Md.), 18, 377-383.
The Treating to New Targets (TNT) trial compared atorvastatin 80 mg (aiming at reducing LDL cholesterol | or = 75 mg/dl) and atorvastatin 10 mg (LDL | or = 100 mg/dl as target) in 10,001 patients with stable coronary heart disease followed up for 5 years. A reduction of major cardiovascular events of 22% was observed in the atorvastatin 80 mg group as compared to the atorvastatin 10 mg group (hazard ratio: 0.78; 95 % interval of confidence: 0.69-0.89; p | 0.001). Such clinical efficacy was obtained while a good drug safety profile was maintained. Total mortality was not significantly different between the two groups. However, and remarkably, cardiovascular death was not the first cause of death anymore in this atorvastatin-treated population. The results of TNT in patients with stable coronary heart disease thus confirm the results of PROVE-IT in patients with acute coronary syndrome. These two randomised controlled trials should encourage considering a LDL cholesterol level of 75 mg/dl (rather than
A high body mass index (BMI) is associated with an increased risk of mortality from coronary heart disease (CHD); however, a low BMI may also be associated with an increased mortality risk. There is limited information on the relation of incident CHD risk across a wide range of BMI, particularly in women. We examined the relation between BMI and incident CHD overall and across different risk factors of the disease in the Million Women Study. 1.2 million women (mean age = 56 years) participants without heart disease, stroke, or cancer (except non-melanoma skin cancer) at baseline (1996 to 2001) were followed prospectively for 9 years on average. Adjusted relative risks and 20-year cumulative incidence from age 55 to 74 years were calculated for CHD using Cox regression. After excluding the first 4 years of follow-up, we found that 32,465 women had a first coronary event (hospitalization or death) during follow-up. The adjusted relative risk for incident CHD per 5 kg/m2 increase in BMI was 1.23 (95%
Lifestyle and risk factor results clearly demonstrate a challenging gap between what is recommended in scientific guidelines and what is achieved in daily practice in high risk individuals in primary prevention of CVD.. Primary prevention of heart disease needs a comprehensive, multidisciplinary approach involving the high-risk population, their GPs and other health professionals, a health insurance system dedicated to prevention and all this complemented by a population strategy involving the community at large.. The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. Guidelines on this important topic have been developed and updated at regular intervals over the last 13 years, most recently in 2007. The implementation of these guidelines is facilitated by the Joint European Prevention Committee and the new European Association for Cardiovascular Prevention and Rehabilitation ...
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
Coronary heart disease (CHD) is the leading cause of death in the United States. Previous research examining physicians ability to estimate cardiovascular risk has shown that physicians generally overestimate the absolute risk of CHD events. This question has, however, only studied risk prediction for a limited number of patient care scenarios. The aim of this study is to measure the ability of physicians to estimate the risk of CHD events in patients with no previous history of coronary heart disease. Twelve primary prevention scenarios with a 5-year risk of CHD events were developed. This questionnaire was surveyed at 3 university teaching hospitals where the participants were a convenience sample of internal medicine residents and fellows or attending physicians in general internal medicine or cardiology. For each scenario, physicians were asked to estimate the baseline 5-year risk of a coronary heart disease event and the revised risk if the patient were to receive lipid-lowering drug therapy.
DALLAS, TX -The American Heart Association (AHA) and Verily, (formerly Google Life Sciences) announced today that AstraZeneca (AZ) has joined them in a bold new approach to find a cure for coronary heart disease and improve cardiovascular health. With a commitment of $75 million dollars over at least a five year period, the three organizations have initiated the single largest research project funding one leader and team in the fight to cure coronary heart disease. The application period for this new research enterprise officially opens today at 5:00 PM ET at: The three organizations have joined forces to find one brave idea from a visionary leader. This person and their team will be awarded the opportunity and challenge to make a difference for the millions of people directly affected by coronary heart disease. Their goal: prevent or reverse coronary heart disease and its consequences, therein restoring cardiovascular health. Launched as One Brave Idea™, this research ...
Objective To assess the effect of using different risk calculation tools on how general practitioners and practice nurses evaluate the risk of coronary heart disease with clinical data routinely available in patients records. Design Subjective estimates of the risk of coronary heart disease and results of four different methods of calculation of risk were compared with each other and a reference standard that had been calculated with the Framingham equation; calculations were based on a sample of patients records, randomly selected from groups at risk of coronary heart disease. Setting General practices in central England. Participants 18 general practitioners and 18 practice nurses. Main outcome measures Agreement of results of risk estimation and risk calculation with reference calculation; agreement of general practitioners with practice nurses; sensitivity and specificity of the different methods of risk calculation to detect patients at high or low risk of coronary heart disease. Results Only a
The Effective Health Care Program of the AHRQ has released summary guides for clinicians and consumers that discuss adjunctive therapy options for patients with stable coronary heart disease.
Treating depression in those with coronary heart disease: CODIACS Vanguard Randomized Controlled Trial. NEW YORK - Depressive symptoms after heart disease are associated with a markedly increased risk of death or another heart attack. However, less has been known about whether treating heart attack survivors for depressive symptoms could relieve these symptoms, be cost-effective, and ultimately, reduce medical risk? Columbia University Medical Centers Karina W. Davidson, PhD and her research team now report a patient-centered approach that answers these questions in the affirmative.. With a grant from the National Institutes of Healths National Heart, Lung, and Blood Institute (NHLBI), Dr. Karina Davidson, director of the Center for Behavioral Cardiovascular Health at CUMC, and her team completed a randomized controlled trial with 150 patients with elevated depressive symptoms two to six months after hospitalization for heart disease. Patients were recruited from seven centers across the ...
TY - JOUR. T1 - Can non-medical factors contribute to disparities in coronary heart disease treatments?. AU - Barnhart, Janice M.. AU - Cohen, Oshra. AU - Wright, Natania. AU - Wylie-Rosett, Judith. PY - 2006/8/1. Y1 - 2006/8/1. N2 - Racial/ethnic and sex disparities in coronary heart disease treatment exist. We previously reported that physicians perceive non-clinical variables, such as a patients desire for a second opinion, as affecting revascularization decisions. The results of that study are further examined here, using factor analysis to identify significant interrelationships among the non-clinical variables, which could contribute to disparities in coronary revascularization (i.e., percutaneous transluminal coronary angioplasty [PTCA] or coronary artery bypass graft [CABG]). Five content themes emerged using factor analysis; these are related to the patients socioeconomic/lifestyle status, treatment preference, physician interaction, health-assertiveness, and aggressiveness. For the ...
Coronary heart disease (CHD) is when your coronary arteries become narrowed by a gradual build-up of fatty material within their walls called atherosclerosis. These arteries supply your heart muscle with oxygen-rich blood. The most common symptom of coronary heart disease (CHD) is chest pain.. You can also experience other symptoms, such as a light headed sensation, palpitations and shortness of breath. Some people may not have any symptoms before they are diagnosed.. Your arteries may become so narrow that they cannot deliver enough oxygen-rich blood to your heart. The pain and discomfort you may feel as a result is called angina.. If a piece of atheroma breaks off it may cause a blood clot to form. If it blocks your coronary artery and cuts off the supply of oxygen-rich blood to your heart muscle, your heart may become permanently damaged. This is known as a heart attack.. There are several ways you can help reduce your risk of developing coronary heart disease (CHD), such as lowering your ...
In the article by Williams et al, Is Optimal Medical Therapy Optimal Therapy for Multivessel Coronary Artery Disease?: Optimal Management of Multivessel Coronary Artery Disease, which appeared in the September 7, 2010 issue of the journal (Circulation 2010;122:943-945), there were two typographical errors:. On page 943, in the fourth paragraph Coronary Artery Surgical Study should read Coronary Artery Surgery Study.. In the same paragraph, European Coronary Surgical Study should read European Coronary Surgery Study.. The text has been corrected in the current online version of the manuscript. The authors regret the error.. ...
Baseline characteristics were compared between people with and without a family history of premature CHD. A Student t test was used for continuous variables (age, body mass index, waist circumference, waist/hip ratio, systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol) a χ2 test was used for categorical variables (sex, smoking status, diabetes mellitus). Because triglycerides and the FRS were not normally distributed, these parameters were log-transformed. The log-transformed variables were normally distributed and were compared using a Student t test.. The Framingham risk score was calculated using a previously reported algorithm, which takes into account age, sex, total cholesterol, HDL cholesterol, systolic and diastolic blood pressure, smoking and the presence of diabetes. Since the FRS overestimates CHD risk in Europeans, and more specifically in the EPIC-Norfolk study population, we recalibrated ...
In this analysis of the data from a longitudinal study on coronary heart disease risk factors, it was found that participants screened a few weeks after a major disaster (earthquake) had a higher heart rate, serum cholesterol levels, and serum triglyceride levels than matched participants that were screened shortly before the catastrophic event. The two groups of participants did not differ with regard to their characteristics at the baseline examination carried out 5 years previously. The lack of difference in blood pressure between exposed and nonexposed participants could be explained by the lag-time between the earthquake and the blood pressure measurements. We conclude that the acute stress associated with major disasters can influence risk factors for coronary heart disease. Permanent elevation of these risk factors due to the disruption of the social environment of the individuals affected by major disasters might be responsible for the apparent long-term adverse effects on cardiovascular ...
3 Department of Epidemiology, School of Public Health, Loma Linda University, Loma Linda, CA. Whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen are considered independent risk factors for coronary heart disease and can be elevated by dehydration. The associations between fatal coronary heart disease and intake of water and fluids other than water were examined among the 8,280 male and 12,017 female participants aged 38-100 years who were without heart disease, stroke, or diabetes at baseline in 1976 in the Adventist Health Study, a prospective cohort study. A total of 246 fatal coronary heart disease events occurred during the 6-year follow-up. High daily intakes of water (five or more glasses) compared with low (two or fewer glasses) were associated with a relative risk in men of 0.46 (95% confidence interval (CI): 0.28, 0.75; p trend = 0.001) and, in women, of 0.59 (95% CI: 0.36, 0.97). A high versus low intake of fluids other than water was associated with a relative risk of ...
Title: Depression in Coronary Heart Disease Patients: Etiological and Screening Issues. VOLUME: 2 ISSUE: 2. Author(s):Colin R. Martin and David R. Thompson. Affiliation:Faculty of Medicine, TheNethersole School of Nursing, Chinese University of Hong Kong, EstherLee Building, Chung Chi College, Shatin, New Territories, Hong Kong,Peoples Republic of China.. Keywords:selective serotonin re-uptake inhibitor (SSRI), sertraline anti-depressant heart attack randomised, trial (SADHART), cardiac rehabilitation (CR), PHQ-2, CHD risk factor. Abstract: Coronary heart disease (CHD) is associated with significant psychiatric comorbidity, in particular, depression. Recent evidence suggests that depression following a coronary event or diagnosis is a significant risk factor for both mortality and morbidity. Further, there is compelling evidence that depression is a significant predictor in the development of CHD. Surprisingly, given the relationship of depression to patient outcome, screening for depressive ...
Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase ...
TY - JOUR. T1 - Coronary heart disease mortality trends in Minnesota, 1960-80. T2 - The Minnesota heart survey. AU - Gillum, R. F.. AU - Hannan, P. J.. AU - Prineas, R. J.. AU - Jacobs, D. R.. AU - Gomez-Marin, O.. AU - Luepker, R. V.. AU - Baxter, J.. AU - Kottke, T. E.. AU - Blackburn, H.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1984. Y1 - 1984. N2 - Age-adjusted mortality rates and trends from coronary heart disease (CHD) in Minnesota for the years 1960 to 1980 differed among eight health service areas. Regression of ten socio-economic and demographic factors and intensive care and coronary care unit beds on area CHD mortality levels revealed a significant positive association only for levels of welfare income-maintenance assistance with CHD mortality levels; there were no associations with trends. Further studies are needed to explain variation within states of CHD mortality rate levels and trends.. AB - Age-adjusted mortality rates and trends from coronary ...
HealthDay News - Incident coronary heart disease (CHD) is associated with accelerated cognitive decline after, but not before, the event, according to a study published in the June 25 issue of the Journal of the American College of Cardiology.. Wuxiang Xie, PhD, from the Peking University Health Science Center in Beijing, and colleagues examined the cognitive trajectory before and after incident CHD diagnosis in a cohort of 7888 participants with no history of stroke or incident stroke during follow-up. Participants underwent a cognitive assessment at baseline in 2002 to 2003 and at least one other time point (from 2004-2005 to 2016-2017). Incident CHD was defined as a diagnosis of myocardial infarction and/or angina during follow-up.. The researchers observed a correlation for incident CHD with accelerated cognitive decline during a median follow-up of 12 years. The annual rate of cognitive decline was similar before CHD diagnosis for individuals who experienced incident CHD and for those who ...
TY - JOUR. T1 - Employment and recreation patterns in patients treated by percutaneous transluminal coronary angioplasty. T2 - A multicenter study. AU - Holmes, David. AU - Vlietstra, Ronald E.. AU - Mock, Michael B.. AU - Smith, Hugh C.. AU - Dorros, Gerald. AU - Cowley, Michael J.. AU - Kent, Kenneth M.. AU - Hammes, La Von N.. AU - Janke, Lynne. AU - Elveback, Lila R.. AU - Vetrovec, George W.. PY - 1983/10/1. Y1 - 1983/10/1. N2 - Employment and recreational patterns were analyzed in 279 patients who underwent percutaneous transluminal coronary angioplasty (PTCA) for treatment of symptomatic coronary artery disease. PTCA was successful in 180 patients (65%). When it was unsuccessful, coronary artery bypass graft surgery was usually performed (80%). Return-to-work rates were high irrespective of the outcome of PTCA. Of patients employed full-time or part-time before treatment, 98.5% of those who had successful PTCA alone and 97% of those whose PTCA was unsuccessful but who underwent ...
From Clinical Nutrition and Risk Factor Modification Center (D.J.A.J., C.W.C.K., A.M., E.V.), Department of Medicine, Division of Endocrinology and Metabolism (P.W.C.), and Department of Surgery, Division of Otolaryngology (W.Q., J.S.H.), St Michaels Hospital, Toronto, Ontario, Canada; Departments of Nutritional Sciences (D.J.A.J., C.W.C.K., A.M., T.L.P., D.F., E.V.), Biochemistry (P.W.C.), and Laboratory Medicine and Pathobiology (P.W.C.), Faculty of Medicine, University of Toronto, Toronto, Ontario; the Almond Board of California (K.G.L.), Modesto, Calif; and Health Research and Studies Center (G.A.S.), Los Altos, Calif. ...
Background The prevalence of coronary heart disease amongst South Asian population in the UK is higher compared to the general population. Objective This study sought to investigate beliefs and experiences of South Asian patients regarding coronary heart disease and medication taking behaviour. Setting A London Heart Attack Centre. Methods This mixed method study is part of an original pilot randomised study on 71 patients involving a pharmacy-led intervention to improve medication adherence in coronary heart disease patients. South Asian patients from the randomised study took part in qualitative semi-structured telephone interviews. Both South Asian and non-South Asian patients completed the questionnaire about adherence and beliefs regarding medicines using Morisky Scale and the Belief About Medicines Questionnaire-Specific at 2 weeks, 3 and 6 months. Outcome Patients beliefs about coronary heart disease and medication adherence. Results Seventeen South Asian patients and 54 non-South Asian ...
TY - JOUR. T1 - The role of public health versus invasive coronary interventions in the decline of coronary heart disease mortality. AU - Myocardial Infarction Data Acquisition System (MIDAS 39) Study Group. AU - Tuppo, Ehab E.. AU - Trivedi, Mihir P.. AU - Kostis, John B.. AU - Daevmer, Julian. AU - Cabrera, Javier. AU - Kostis, William J.. N1 - Funding Information: The authors would like to thank Dr. George Rhoads for his help in the research and data analysis and Dr. John Pantazopoulos for his help in the discussion. Publisher Copyright: © 2020 Elsevier Inc.. PY - 2021/3. Y1 - 2021/3. N2 - Purpose: There has been considerable debate on the extent to which the decline in coronary heart disease (CHD) mortality has been caused by better control of coronary risk factors in the general population or is the result of invasive coronary interventions in symptomatic individuals. Methods: Using the Myocardial Infarction Data Acquisition System, a statewide database of all cardiovascular hospital ...
Despite advances made in treating coronary heart disease (CHD), mortality due to CHD in Syria has been increasing for the past two decades. This study aims to assess CHD mortality trends in Syria between 1996 and 2006 and to investigate the main factors associated with them. The IMPACT model was used to analyze CHD mortality trends in Syria based on numbers of CHD patients, utilization of specific treatments, trends in major cardiovascular risk factors in apparently healthy persons and CHD patients. Data sources for the IMPACT model included official statistics, published and unpublished surveys, data from neighboring countries, expert opinions, and randomized trials and meta-analyses. Between 1996 and 2006, CHD mortality rate in Syria increased by 64%, which translates into 6370 excess CHD deaths in 2006 as compared to the number expected had the 1996 baseline rate held constant. Using the IMPACT model, it was estimated that increases in cardiovascular risk factors could explain approximately 5140 (81%
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This study examines the joint and separate influence of birth weight and body mass in young adulthood on subsequent coronary heart disease (CHD) risk. A cohort of 9,143 men born in Copenhagen, Denmark, in 1953, for whom information on birth weight and body weight and height around age 19 years were retrieved from birth certificates and conscript records, respectively, were followed from 1978 until 2005 (between age 25 and 52 years) for incident fatal and non-fatal CHD. Data on CHD were obtained through record linkage to the Cause of Death Registry and the National Patient Registry. During follow-up, a total of 475 men had a CHD diagnosis. Men with low birth weight, high body mass index (BMI) at age 19, a father from the working class, and low educational level at age 19 had an increased risk for CHD. Birth weight was inversely associated with CHD only in men with BMI of 25 kg/m(2) or above. Adjustment for childhood social circumstances and educational status at age 19 had minor influence on the ...
Motlagh B, ODonnell M, Yusuf S. Prevalence of cardiovascular risk factors in the Middle East: a systematic review. Eur J Cardiovasc Prev Rehabilm2009;16(3):268-80. Cole JH, Sperling LS. Premature coronary artery disease:clinical risk factors and prognosis. Curr Atheroscler Rep2004;6(2):121-5. Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalized anxiety disorder: a 10-year follow-up. Br J Psychiatry 2012;200(4):324-9. Martens EJ, de Jonge P, Na B, et al. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010;67(7):750-8. Huffman JC, Smith FA, Blais MA, et al. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res 2008;65(6):557-63. Kawachi I, Sparrow D, Vokonas PS, et al. Symptoms of anxiety and risk of coronary heart disease. The NormativeAging Study. Circulation ...
TY - JOUR. T1 - Sleep duration, sleep quality and coronary heart disease mortality. AU - Strand, Linn B.. AU - Tsai, Min Kuang. AU - Gunnell, David. AU - Janszky, Imre. AU - Wen, Chi Pang. AU - Chang, Shu-Sen. PY - 2016/11/15. Y1 - 2016/11/15. KW - Sleep. KW - coronary heart disease. KW - cardiovascular disease. KW - sleep duration. KW - sleep quality. U2 - 10.1016/j.ijcard.2016.08.119. DO - 10.1016/j.ijcard.2016.08.119. M3 - Letter (Academic Journal). C2 - 27552574. VL - 223. SP - 534. EP - 535. JO - International Journal of Cardiology. JF - International Journal of Cardiology. SN - 0167-5273. ER - ...
The most abundant steroid in the human body, dehydroepiandrosterone (DHEA) is involved in the manufacture of testosterone, estrogen, progesterone, and corticosterone. Claes Ohlsson, from Sahlgrenska Academy (Sweden), and colleagues monitored 2,614 men, ages 69 to 80 years, who resided in 3 Swedish communities, for five years, during which DHEA levels were assessed. The findings demonstrated that the lower the DHEA level at the study start, the greater the risk of coronary heart disease events during the five-year follow-up. The study authors report that: Low serum levels of DHEA and its sulfate predict an increased risk of [coronary heart disease], but not [cerebrovascular disease], events in elderly men.. Asa Tivesten; Liesbeth Vandenput; Daniel Carlzon; Maria Nilsson; Magnus K. Karlsson; Claes Ohlsson; et al. Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men. J Am Coll Cardiol. 2014; 64(17):1801-1810.. ...
A comprehensive study in this weeks PLoS Medicine shows levels of the amino acid, homocysteine, have no meaningful effect on the risk of developing coronary heart disease, closing the door on the previously suggested benefits of lowering homocysteine with folate acid once and for all.. Previous studies have suggested that high blood levels of homocysteine might be a modifiable risk factor for coronary heart disease, but in a detailed analysis of data from 19 unpublished and 86 published studies, led by Robert Clarke from the Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford, the researchers found that lifelong moderate elevation of homocysteine levels had no significant effect on the risk of developing coronary heart disease. The study findings suggest that extensive publication bias, together with methodological problems, has played a role in previous suggestions linking homocysteine with coronary heart disease risk.. In their analysis, the authors found ...
TY - JOUR. T1 - A comparison of coronary heart disease event rates amoung urban Australian Aboriginal people and a matched non-Aboriginal population. AU - Bradshaw, Pamela. AU - Alfonso-Parada, Helman. AU - Finn, Judith. AU - Owen, Julie. AU - Thompson, Peter. PY - 2011. Y1 - 2011. U2 - 10.1136/jech.2009.098343. DO - 10.1136/jech.2009.098343. M3 - Article. VL - 65. SP - 315. EP - 319. JO - Journal of Epidemiology & Community Health. JF - Journal of Epidemiology & Community Health. SN - 0143-005X. ER - ...
PURPOSE: In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.METHODS: Data on 13,051 patients ages 45 to 64 years from the Atherosclerosis Risk in Communities study were analyzed. The ARIC food frequency questionnaire baseline data provided GI and GL indices. A propensity score was created to estimate the effect of a patients covariates on energy-adjusted GI or GL. During a maximum of 17 years of follow-up, 1683 cases of CHD (371 with diabetes and 1312 without diabetes) were recorded.RESULTS: For every 5-units increase in GI, there was a 1.16-fold (95% confidence interval [95% CI], 1.01-1.33) increased risk of incident CHD in African Americans. For every 30-units increase in GL, there was a 1.11-fold (95% CI, 1.01-1.21) increased risk of incident CHD in Whites. High GL was an especially important CHD risk factor for ...
Design, setting and participants: A CVD risk-factor survey was carried out in rural south-eastern Australia from 2004 to 2006. Using a stratified random sample, data for 1116 participants aged 35-74 years were analysed. Applying the Framingham risk equations to risk-factor data, 5-year probabilities of a coronary heart disease event, stroke and cardiovascular event were calculated. The effect of different changes in risk factors were modelled to assess the extent to which cardiovascular diseases can be prevented by changing the risk factors at a population level (population strategy), among the high-risk individuals (high-risk strategy) or both ...
Using mortality data from National Institute of Statistics in Spain, we analyzed trends of infectious disease mortality rates in Spain during 1980-2011 to provide information on surveillance and control of infectious diseases. During the study period, 628,673 infectious disease-related deaths occurred, the annual change in the mortality rate was −1.6%, and the average infectious disease mortality rate was 48.5 deaths/100,000 population. Although the beginning of HIV/AIDS epidemic led to an increased mortality rate, a decreased rate was observed by the end of the twentieth century. By codes from the International Classification of Diseases, 9th revision, the most frequent underlying cause of death was pneumonia. Emergence and reemergence of infectious diseases continue to be public health problems despite reduced mortality rates produced by various interventions. Therefore, surveillance and control systems should be reinforced with a goal of providing reliable data for useful decision making.
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Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. Clinical data,operative success rate,locations of coronary artery lesions,number of implanted stents,clinical outcome,hospitalization related expenses and incidence of complications were compared between the two groups. Results Patients of the two groups completed the operation successfully,the operative success rates of the two
JA Allen, LA Throm; Percutaneous transluminal coronary angioplasty: a new alternative for ischemic heart disease. Crit Care Nurse 1 January 1982; 2 (1): 24-29. doi: Download citation file:. ...
Background This study sought to determine the relation between and discriminative capability of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and coronary heart disease (CHD) in a large population of disease-free women.Methods Among participants of the Nurses Health Study who provided a blood sample, there were 421 cases of incident myocardial infarction during 14 years of follow-up. Controls were matched to cases 2:1 using risk set sampling based on age, smoking, and blood draw date.Results After conditioning on the matching factors, Lp-PLA(2) activity was significantly associated with myocardial infarction (relative risk [RR] 2.86 for extreme quartiles, 95% CI 1.98-4.12). Upon additional adjustment for lipid, inflammatory, and clinical risk factors, the RR remained statistically significant (RR 1.75, 95% CI 1.09-2.84). The discriminative capability of Lp-PLA(2) was assessed by comparing the area below the receiver operating characteristic curves for models with and without Lp-PLA(2) ...
Percutaneous transluminal coronary angioplasty (PTCA) is a minimally invasive procedure to open up blocked coronary arteries, allowing blood to circulate unobstructed to the heart muscle. Market Analysis and Insights: Global Percutaneous Translumi
Considerable epidemiological evidence has accumulated regarding the effect of postmenopausal estrogens on coronary heart disease risk. Five hospital-based case-control studies yielded inconsistent but generally null results; however, these are difficult to interpret due to the problems in selecting …
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The market for technologies and products in the treatment of coronary heart disease is forecast to grow from $12.2 billion in 2014 to $22.5 billion in 2021, according to a new study from Smithers.. Treatment of coronary artery disease by interventional cardiology, through angioplasty and stenting, remains competitive in its clinical outcomes and cost compared to traditional coronary artery bypass graft (CABG) and emerging minimally invasive alternatives to CABG. Further, manufacturers have largely eliminated the concerns about late stent thrombosis that caused a market slowdown in stents, as they have aggressively developed technology developments in stents, their composite materials, and coatings.. A new study from Smithers - The Future of Coronary Heart Disease Medical Devices to 2021 - shows the continued demand for these devices as clinically and cost-effective solutions to coronary artery disease. In the largest product area, coronary stents, despite an upwards of 90% penetration of ...
Background. The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.. Methods. Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randoxs Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).. Results. Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the ...
In the present study of older community-dwelling individuals, Lp-PLA2 levels were significantly higher in those who developed CHD compared with those who did not. Associations between Lp-PLA2 and LDL, HDL, total cholesterol, and triglycerides were especially strong, and the magnitude of the correlations was in good agreement with previous studies (7,19). Despite these associations, Lp-PLA2 remained a strong and independent predictor of fatal and nonfatal CHD events, over and above these and other traditional risk factors. Thus, Lp-PLA2 added information to lipid and lipoprotein prediction of future CHD and may identify subpopulations at risk for CHD who would not be identified otherwise.. A similar independent association of Lp-PLA2 with CHD risk was reported in the younger participants from the WOSCOPS (5) and ARIC (7,19) studies and in a nested case-control study from the Rotterdam study (9). We now confirm these results for the first time in a cohort of apparently healthy older men and women ...
Finland has marked regional differences in the occurrence of coronary heart disease (CHD). Although the causes for these differences in CHD mortality and morbidity in the Finnish population are unknown, it offers an excellent opportunity to investigate the effects of non-insulin-dependent diabetes mellitus (NIDDM) on CHD risk in two populations differing significantly with respect to the occurrence of CHD. Therefore, we carried out a 7-year prospective population-based study including a large number of patients with NIDDM (East Finland: 253 men and 257 women; West Finland: 328 men, 221 women) and corresponding non-diabetic subjects (East Finland: 313 men, 336 women; West Finland: 325 men, 399 women). In both study populations the presence of NIDDM increased significantly the risk for CHD events (CHD mortality or all CHD events including CHD mortality or non-fatal myocardial infarction). Diabetic men had 3-4 fold higher and diabetic women 8-11-fold higher risk for CHD than corresponding non-diabetic
Subclinical heart disease has been reported to be an independent predictor of CAD risk in the general population. Women with subclinical disease were at greater risk for acute MI.47 Early investigation for CAD in the preclinical stage in young women with SLE is justified because cardiovascular events are an important cause of morbidity and mortality in this population. Published reports show that coronary disease (angina pectoris or acute MI) is more common in women with SLE than in the general population. Moreover, the mean age of patients with SLE who had coronary disease was younger than seen in the general population.4. We studied patients with more than five years of SLE, who had used steroids for at least one year, in attempt to evaluate patients at a greater risk for CAD.10-11,16,48 We analysed only asymptomatic patients, because we wanted to investigate subclinical heart disease. We also excluded patients older than 55 years, because women after this age have higher risk for CAD than ...
Coronary heart disease (CHD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. You can read more information on this at the National Heart Lung and Blood Institute website.. We had this requirement come in from a partner on how we could store all the patient vital data within Dynamics 365 and calculate a risk score. Our example shows how to use North52s business rules engine for Dynamics 365 to set up a Multi-Sheet Decision Table to evaluate the patients risk score of Coronary Heart Disease.. Each Decision Table Sheet will evaluate specific Risk Factors with a variety of Conditions and decide if that risk factor applies to the patient. A final Decision Table Sheet will then provide a Risk Score based on the individual Risk Factors.. For this article it is assumed that you have at least basic familiarity with Decision Tables and/or have read the following articles:. ...
A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD). Many clinical trials aimed to test this advice and have had their results pooled in several meta-analyses. However, earlier meta-analyses did not sufficiently account for major confounding variables that were present in some of those trials. Therefore, the aim of the study was to account for the major confounding variables in the diet heart trials, and emphasise the results from those trials that most accurately test the effect of replacing SFA with mostly n-6 PUFA.. Design Clinical trials were identified from earlier meta-analyses. Relevant trials were categorised as adequately controlled or inadequately controlled depending on whether there were substantial dietary or non-dietary differences between the experimental and control groups that were not related to SFA or mostly n-6 PUFA ...
Coronary heart disease (CHD) is the most common cause of death and disability in the United Kingdom. It causes around 94,000 deaths in the UK each year and around one in five men and one in seven women will die from the disease.. Coronary heart disease is usually caused by atherosclerosis, where fatty deposits (atheroma) develop in the walls of the arteries. Atherosclerosis causes symptoms when it partially or completely blocks the arteries that supply the heart muscle with blood. This manifests as a number of conditions including stable angina (where atheroma restricts blood flow) and acute coronary syndromes (where clot formation occurs on the atheroma and causes an abrupt narrowing or complete blockage of the artery). These are described in the relevant sections.. There are two ways to improve blood flow to heart muscle when the arteries become blocked. Percutaneous Coronary Intervention (PCI) and surgical coronary artery bypass grafting (CABG).. PCI is performed under local anaesthetic. A ...
... (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or ... MedlinePlus Encyclopedia: Coronary heart disease "What Are the Signs and Symptoms of Coronary Heart Disease?". 29 September ... Antibiotics for secondary prevention of coronary heart disease Antibiotics may help patients with coronary disease to reduce ... Typically, coronary artery disease occurs when part of the smooth, elastic lining inside a coronary artery (the arteries that ...
... is a protein that in humans is encoded by the CHDS8 gene. "Human PubMed Reference ... "Entrez Gene: Coronary heart disease, susceptibility to, 8". Retrieved 2018-06-06. v t e (Articles with short description, Short ...
"Aspirin in coronary heart disease. The Coronary Drug Project Research Group". Circulation. 62 (6 Pt 2): V59-62. December 1980. ... Coronary Drug Project Research Group (May 1977). "Gallbladder disease as a side effect of drugs influencing lipid metabolism. ... "The Coronary Drug Project. Findings leading to discontinuation of the 2.5-mg day estrogen group. The coronary Drug Project ... The Coronary Drug Project (CDP) was a large clinical trial which assessed several different treatments for coronary heart ...
Chun AA, McGee SR (2004). "Bedside diagnosis of coronary artery disease: a systematic review". Am. J. Med. 117 (5): 334-43. doi ... Acute coronary syndrome (ACS) is a syndrome (a set of signs and symptoms) due to decreased blood flow in the coronary arteries ... Acute coronary syndrome often reflects a degree of damage to the coronaries by atherosclerosis. Primary prevention of ... "Valvular Heart Disease"]. "Valvular Heart Disease". {{cite journal}}: Cite journal requires ,journal= (help)CS1 maint: multiple ...
Coronary artery disease (CAD) is the most common cause of coronary ischemia. Coronary ischemia and coronary artery disease are ... "Ischemia." Ischemic Heart Disease. Ischemic Heart Disease, n.d. Web. 6 Nov. 2010.] ""Coronary Artery Disease". Adult Health ... Gerstenblith G, Margolis S (January 2008). "Diagnosis of Coronary Heart Disease". Coronary Heart Disease. Baltimore, Md: Johns ... Coronary ischemia is linked to heart disease, and heart attacks. Coronary arteries deliver oxygen-rich blood to the heart ...
... to keep the arteries open in the treatment of coronary heart disease. It is used in a procedure called percutaneous coronary ... Similar stents and procedures are used in non-coronary vessels (e.g., in the legs in peripheral artery disease). An artery with ... The MASS-II trial compared PCI, CABG and optimum medical therapy for the treatment of multi-vessel coronary artery disease. The ... COURAGE concluded that in patients with stable coronary artery disease PCI did not reduce the death, myocardial infarction or ...
2012). "Percutaneous coronary intervention versus optimal medical therapy in stable coronary artery disease: a systematic ... after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a ... implications of coronary calcification in patients with obstructive coronary artery disease treated by percutaneous coronary ... is a non-surgical procedure used to treat narrowing of the coronary arteries of the heart found in coronary artery disease. The ...
It may be useful in the diagnosis of suspected coronary heart disease, for follow-up of a coronary artery bypass, for the ... Accuracy of CT Coronary Angiography According to Pretest Probability of Coronary Artery Disease and Severity of Coronary ... the test says they do not have coronary artery disease), 7 will actually have the disease as defined by the reference standard ... usually in order to diagnose coronary artery disease. CTA is superior to coronary CT calcium scan in determining the risk of ...
... especially in patients with congenital coronary artery aneurysms Coronary artery disease (atherosclerosis) Vasculitic and ... In Kawasaki's disease, untreated, there is a 1-2% death rate, from cardiac causes.[citation needed] The prognosis of coronary ... Diseases of the aorta, Heart diseases, All stub articles, Circulatory disease stubs). ... May 2007). "Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence". Circ. J. 71 (5 ...
The surgery has recently begun to be used in multi-vessel coronary disease. People with multi-vessel coronary disease, who ... Minimally invasive direct coronary artery bypass (MIDCAB) is a surgical treatment for coronary heart disease that is a less ... A hybrid approach combines coronary bypass (using the MIDCAB approach) and coronary stenting. Cardiac surgeon Cardiac surgery ... MIDCAB is a form of off-pump coronary artery bypass surgery (OPCAB), performed "off-pump" - without the use of cardiopulmonary ...
... venous coronary artery bypass grafts in 366 adult patients (14% of the patients) with complex coronary artery disease. Their ... "Simultaneous Hybrid Revascularization Versus Off-Pump Coronary Artery Bypass for Multivessel Coronary Artery Disease". The ... Heart disease Murphy, Gavin J; Bryan, Alan J; Angelini, Gianni D (2004). "Hybrid Coronary Revascularization in the Era of Drug- ... A study from FuWai Hospital in Beijing reports on 104 patients with multivessel coronary artery disease who were compared with ...
Talarico GP, Crosta ML, Giannico MB, Summaria F, Calò L, Patrizi R (May 2017). "Cocaine and coronary artery diseases: a ... Angina due to coronary vasospasm is also known as variant angina. Hung, Ming-Jui; Hu, Patrick; Hung, Ming-Yow (2014). "Coronary ... Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion. In ... Due to the challenge of capturing episodes of coronary vasospasm spontaneously, provocative testing to induce coronary ...
Impaired endothelial function, causing hypertension and thrombosis, is often seen in patients with coronary artery disease, ... Coronary Artery Disease. 17 (7): 611-21. doi:10.1097/01.mca.0000224420.67304.4d. PMID 17047445. S2CID 1884596. Soni D, Wang DM ... A Mediterranean diet has been found to improve endothelial function in adults which can reduce risk of cardiovascular disease. ... Mäyränpää MI, Heikkilä HM, Lindstedt KA, Walls AF, Kovanen PT (November 2006). "Desquamation of human coronary artery ...
... coronary heart disease; hypertension; diabetes; HIV/AIDS; haemophilia; depression; bipolar disorder; rheumatoid arthritis; ... 2009). "Patients' attitudes to medicines and adherence to maintenance treatment in inflammatory bowel disease". Inflamm Bowel ... inflammatory bowel disease and also for newly prescribed medications in primary care. His current research focuses on the ...
"Coronary Heart Disease". Weitz & Luxenberg P.C. Archived from the original on May 30, 2013. Retrieved March 20, 2013. "Kidney ... A headache in a patient taking medication for influenza may be caused by the underlying disease or may be an adverse effect of ... Adverse effects may cause complications of a disease or procedure and negatively affect its prognosis. They may also lead to ... "Possible Side-effects from Vaccines". Centers for Disease Control and Prevention (CDC). 2018-07-12. Archived from the original ...
Gundu HR Rao, S Thanikachalam (2005). Coronary Artery Disease. Jaypee Publications. p. 324. ISBN 9788180614507. Retrieved 28 ...
Coronary heart disease, also known as coronary artery disease, is one of the most common causes of myocardial damage, affecting ... In coronary heart disease, the coronary arteries narrow due to the buildup of atheroma or fatty deposits on the vessel walls. ... "CORONARY HEART DISEASE". Merriam-Webster. Retrieved 2020-03-23. CDC (2019-11-22). "What are Congenital Heart Defects? , CDC". ... The accumulation of the fibrotic tissue is much slower in coronary heart disease compared to an infarction because the tissue ...
The global burden of disease 2004 update. Geneva: WHO. ISBN 92-4-156371-0. "Coronary Artery Disease". ... It is a disease with high mortality rate and high morbidity. Failure to treat could cause chronic kidney disease and a need for ... In most Western countries, Ischemic heart disease is the most common cause of death in both men and women, and a major cause of ... Occlusive Peripheral Arterial Disease, The Merck Manual Home Health Handbook website, revised and updated March 2010. Retrieved ...
Central obesity is positively associated with coronary heart disease risk in women and men. It has been hypothesized that the ... Barrett-Connor E (January 1997). "Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys ... Obesity (Silver Spring) 2007;15 (1) 216- 224] Wingard DL (May 1990). "Sex differences and coronary heart disease. A case of ... Poehlman ET (1998). "Abdominal Obesity: The Metabolic Multi-risk Factor". Coronary Heart Disease. 9 (8): 469-471. doi:10.1097/ ...
Coronary Artery Disease. 38 (4): 563-573. doi:10.1016/j.ccl.2020.07.001. ISSN 0733-8651. PMID 33036718. S2CID 222255783. Kloner ... Coronary no-reflow phenomenon is specifically related to reduced antegrade coronary blood flow despite proximal coronary artery ... It is primarily seen during percutaneous coronary intervention (PCI) in the setting of acute myocardial infarction (AMI), but ... Micromembolization can occur during primary percutaneous coronary intervention (pPCI) to revascularize an occluded epicardial ...
A 2014 meta-analysis concluded that cardiovascular disease, such as coronary artery disease and stroke, is less likely with ... Moderate coffee consumption is not a risk factor for coronary heart disease. A 2012 meta-analysis concluded that people who ... Coronary Artery Disease. 27 (7): 566-572. doi:10.1097/MCA.0000000000000397. PMID 27315099. S2CID 7980392. Archived from the ... "Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies". International ...
Coronary artery disease is the leading cause of death in the US general population. Hypercholesterolemia or high cholesterol is ... McCullough, P. A. (11 April 2007). "Coronary Artery Disease". Clinical Journal of the American Society of Nephrology. 2 (3): ... considered a major risk factor in coronary artery disease. Therefore, major efforts are focused toward understanding regulation ...
Coronary Artery Disease. 23 (6): 368-74. doi:10.1097/MCA.0b013e3283564930. PMID 22735090. S2CID 2870694. Oliveira AG, Marques ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the peritoneal fluid. It binds ... Mustafa SJ, Morrison RR, Teng B, Pelleg A (2009). "Adenosine receptors and the heart: role in regulation of coronary blood flow ...
There is also a correlation between those with diseases such as chronic kidney disease, coronary artery disease, or diabetes ... Bell, David S.H. (October 1996). "Diabetes mellitus and coronary artery disease". Coronary Artery Disease. 7 (10): 715-722. doi ... Statins are a class of drugs used to treat cardiovascular disease by lowering lipid levels, specifically LDL-C levels. Statins ... Brown, William Virgil (2018-07-12). "Clinical Lipidology and the Prevention of Vascular Disease: Time for Personalized Therapy ...
Coronary Artery Disease (CAD) results from the stenosis of coronary arteries by an atherosclerotic plaque. The coronary ... Common diseases of arterial occlusion include Coronary Artery Disease, Peripheral Artery Disease, and Pulmonary Embolism. ... These three types of occlusion underlie various common conditions, including coronary artery disease, peripheral artery disease ... "Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review". The Journal of ...
"Left anterior descending artery length in left and right coronary artery dominance". Coronary Artery Disease. 12 (1): 77-78. ...
"Absolute coronary artery calcium scores are superior to MESA percentile rank in predicting obstructive coronary artery disease ... A coronary CT calcium scan is a computed tomography (CT) scan of the heart for the assessment of severity of coronary artery ... Use of new imaging techniques to screen for coronary artery disease". Circulation. 108 (8): e50-3. doi:10.1161/01.CIR. ... However, coronary CT angiography (CTA) is superior to coronary CT calcium scanning in determining the risk of Major Adverse ...
Coronary arteries Coronary circulation Coronary artery disease Costanzo, Linda S. (2011). Physiology (5th ed.). Philadelphia: ... CPP becomes relevant in coronary artery disease as atherosclerosis causes stenosis of the coronary arteries. The arteries ... Because coronary flow is determined partly by coronary perfusion pressure, a reduction in CPP increases the risk of T2MI. ... Coronary perfusion pressure (CPP) refers to the pressure gradient that drives coronary blood pressure. The heart's function is ...
Atherosclerosis is the leading cause of coronary artery disease. And, ischaemic heart disease is the leading cause of mortality ... "Coronary Artery Disease (CAD)". Retrieved 18 January 2021. "The top 10 causes of death". Retrieved 2 January ... Ahrens, E.H. (1979). "Dietary Fats and Coronary Heart Disease: Unfinished Business". The Lancet. 314 (8156-8157): 1345-1348. ... low cholesterol diet in secondary prevention of coronary heart disease. Advances in Experimental Medicine and Biology. Vol. 109 ...
A Comprehensive Approach to the Diagnosis of Diseases of the Heart. Med Clin North Am. 1939;23(4):1007-1019. Coronary disease ... Tobacco and Coronary Disease. JAMA. 1940;115(16):1327-1329. Willius, F.A. and T.J. Dry. The Prognosis of Auricular Fibrillation ... Disease of the Coronary Arteries Associated With Thrombo-Angiitis Obliterans of the Extremities. Ann Intern Med. 1929;3(1):35- ... Disease of the Coronary Arteries Associated With Thrombo-Angiitis Obliterans of the Extremities. Ann. Intern. Med. 1929;3(1):35 ...
Joseph Sargent, 89, American film director (The Taking of Pelham One Two Three, MacArthur, Jaws: The Revenge), heart disease. ... Ziad Abu Ein, 55, Palestinian politician, coronary blockage from heart hemorrhage. John P. Anton, 94, American philosopher. ... Bill J. Dukes, 87, American politician, member of the Alabama House of Representatives (1994-2010), Parkinson's disease. Claude ... Fuzzy Thurston, 80, American football player (Green Bay Packers), Alzheimer's disease and cancer. Johnny Treadwell, 73, ...
The AV node lies at the lower back section of the interatrial septum near the opening of the coronary sinus, and conducts the ... Atrioventricular conduction disease (AV block) describes impairment of the electrical continuity between the atria and ... The origin of this artery is most commonly (80-90% of hearts) a branch of the right coronary artery, with the remainder ... This is associated with the dominance of the coronary artery circulation. In right-dominant individuals the blood supply is ...
... for coronary artery disease in multiple vessels Developed the first steerable coronary guidewire First advanced coronary ...
414.11 Aneurysm of coronary vessels 414.12 Dissection of coronary artery 414.8 Ischemic heart disease, chronic, other 414.9 ... heart disease 403 Hypertensive renal disease 403.0 Malignant hypertensive renal disease 403.1 Benign hypertensive renal disease ... 440 Atherosclerosis 440.1 Stenosis of renal artery 440.2 Peripheral Arterial Disease 440.21 Peripheral Arterial Disease with ... 436 Acute but ill-defined cerebrovascular disease 437 Other and ill-defined cerebrovascular disease 437.0 Cerebral ...
A Textbook of Coronary, Peripheral, and Structural Heart Disease. CRC Press. p. 275. ISBN 978-0-203-09304-7. Retrieved April 25 ... Allen, Hugh D. (2008). Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult ... Mullins authored Cardiac Catheterization in Congenital Heart Disease: Pediatric and Adult in 2006. The book was reviewed in the ... "Mullins Lecture to focus on innovation in stenting for congenital heart disease". Society for Cardiovascular Angiography and ...
Microrobot moving controlled through blood vessel for drug delivery and treatment of coronary artery disease such as CTO( ...
He had severe coronary artery disease similar to Sergey Grinkov. List of sportspeople who died during their careers Olympic ...
To combat the disease, he underwent an extremely rare heart-liver transplant on the morning of June 14, 1993 at the University ... In October 1987, Casey suffered a heart attack and underwent quadruple coronary artery bypass surgery. In 1991, during his ... Though rare, the disease had also claimed the lives of Pittsburgh Mayor Richard Caliguiri and Erie Mayor Louis Tullio in 1988 ... The announcement of Casey's disease was made just days before he underwent the transplant, and as a result many accused him of ...
... and/or one of its CMTM5 proteins may promote atherosclerosis-based coronary artery disease and the stenosis of coronary artery ... Liu TF, Lin T, Ren LH, Li GP, Peng JJ (December 2020). "[Association between CMTM5 gene and coronary artery disease and the ... 350 patients with coronary artery disease were significantly higher than a matched group of 350 patients without this disease. ... diseases and can serve as clinical markers of disease severity and/or as therapeutic targets for controlling the diseases. ...
Research suggested that the leading health problem among its people is coronary disease, therefore the leaders issued laws in ... "Noncommunicable diseases in Bahrain" (PDF). World Health Organization. Retrieved 26 June 2012. "Features of sickle-cell disease ... Cardiovascular diseases account for 32% of all deaths in Bahrain, being the number one cause of death in the country (the ... Malaria and tuberculosis (TB) do not constitute major problems in Bahrain as neither disease is indigenous to the country. As a ...
... below Coronet or coronary band: the ring of soft tissue just above the horny hoof that blends into the skin of the leg Crest: ... Diseases and surgery of the globe and orbit". In Gilger, BC (ed.). Equine Ophthalmology (3rd ed.). John Wiley & Sons. p. 151. ...
An Intermediate Coronary Care Unit was opened in the year 2001. Department of Cardiothoracic Surgery: started in 1956 with Dr. ... Department of Tuberculosis and Chest Diseases Department of Urology Andhra Medical College Central library was established in ... 2010). End Stage Renal Disease, ECAB Clinical Update. New Delhi: Elsevier. p. 1. ISBN 978-8131232019. "AMC Neurosurgery Dept. ... Hospital For Mental Care Rani Chandramani Devi Government Hospital Government Hospital for Chest and Communicable Diseases ...
... research also shows that drinking moderate amounts of alcohol may protect healthy adults from developing coronary heart disease ... that drinking moderate amounts of alcohol can protect the hearts of some people from the risks of coronary artery disease. But ...
This category includes coronary heart disease, stroke and heart attack. Heart disease is the leading cause of death worldwide ... Gum disease has been linked to diseases such as cardiovascular disease. Diseases of poverty reflect the dynamic relationship ... Both low income and low education were predictors of coronary heart disease, a subset of cardiovascular disease. Of those ... These diseases produced in part by poverty are in contrast to diseases of affluence, which are diseases thought to be a result ...
... coronary heart disease and arthritis. She was the first female recipient of the Rutherford Medal and in 1988 was elected a ... At higher levels, they can lead to oxidative stress, which has been implicated in a wide range of human diseases. Winterbourne ... Pham-Huy, Lien Ai; He, Hua; Pham-Huy, Chuong (June 2008). "Free Radicals, Antioxidants in Disease and Health". International ... did early work to document some of the chemical reactions of free radicals that occur in diseases such as cancer, stroke, ...
"The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research ...
Several diseases can result from consuming large amounts of these unhealthy food options, including cardiovascular disease, ... A 2011 review used fifteen years of data from the Coronary Artery Risk Development in Young Adults (CARDIA) study to examine ... Such diseases include scurvy, which results from low vitamin C levels; rickets, from low vitamin D levels; and pellagra, from ... They believed their current health conditions to be shaped by their eating behaviors when the future chronic disease risk was ...
Goldschmidt's research applies genomics and cell therapy to the prevention, diagnosis and treatment of coronary artery disease ...
... and completing Coronary artery bypass surgery, more and more necessary for the aging population. Several randomized controlled ... A prospective study of a vein sparing technique for the management of varicose vein disease The American Journal of Surgery - ...
... coronary heart disease, and cerebrovascular disease, because they ate mostly lean meats and plants and frequently engaged in ... It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ... wild foods signal relief from diseases of affluence (PDF)" (PDF). In Ungar, Peter S.; Teaford, Mark F. (eds.). Human Diet: Its ... caused by other factors such as disease and overhunting by humans. New research suggests that the extinction of the woolly ...
... fistula Coronary arteries congenital malformation Coronary artery aneurysm Coronary heart disease Coronavirus disease 2019 ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ... Tooth disease Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease deafness dominant type Charcot-Marie-Tooth disease ...
... studies that showed an inverse correlation between serum bilirubin level and prevalences of ischemic coronary artery disease, ... In Crigler Najjar disease, there is an inherited deficiency of glucuronyl transferase resulting in high concentrations of ... "Diseases Associated with Hyperbilirubinemia". 1995-01-05. Archived from the original on 2019-05-06. ... Bilirubin concentration is not a sensitive early indicator of liver diseases as the liver may have reserved its capacity in ...
Blaiberg's autopsy showed severe and widespread coronary artery disease, a precursor to atherosclerosis. Barnard said " ... a 55-year-old man suffering from diabetes and heart disease. With the transplanted heart from Denise Darvall, a victim of a ...
... and cardiovascular diseases, and on evidence-based policy approaches and innovations to reduce these burdens in the US and ... and Supplement Fatty Acids With Coronary Risk". Annals of Internal Medicine. 160 (6): 398-406. doi:10.7326/M13-1788. PMID ... a controversial meta-analysis pertaining to the association between saturated fat consumption and risk of heart disease. ...
He is widely recognized for his scholarly contributions to the domains of acute coronary syndrome, left ventricular repair and ... "Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases". ... 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment ... Schäfer, Andreas; Bauersachs, Johann (2021-11-03). "P2Y12 inhibition in acute coronary syndromes treated with percutaneous ...
"Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis ... "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 ( ...
Coronary artery disease (narrowed coronary arteries) Arrhythmia (irregular heartbeat) Cardiomyopathy (disease of the heart ...
Russell died in Nicholasville, Kentucky, of coronary artery disease on November 19, 1992. He was 52 years old. Whitburn, Joel ( ...
... is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress TSH ... starting at higher doses may cause an acute coronary syndrome or an abnormal heart rhythm. Hypothyroidism is common among ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ... Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ...
SPECT is most commonly used for myocardial perfusion imaging to detect ischemic heart disease. Coronary catheterization uses ... A coronary CT calcium scan is a computed tomography (CT) scan of the heart for the assessment of severity of coronary artery ... Coronary angiography is used to determine the patency and configuration of the coronary artery lumens. Intravascular ultrasound ... "Assessment of Agatston Coronary Artery Calcium Score Using Contrast-Enhanced CT Coronary Angiography". American Journal of ...
Learn what causes coronary artery disease (CAD) and how it is diagnosed. Get the facts from the CDC. ... What is coronary artery disease?. Coronary artery disease (CAD) is the most common type of heart disease in the United States. ... Learn the facts about heart disease, including coronary artery disease, the most common type of heart disease. ... How is coronary artery disease diagnosed?. If youre at high risk for heart disease or already have symptoms, your doctor can ...
... is the most common type of heart disease. It can lead to angina and heart attack. Read about symptoms and tests. ... Coronary Artery Disease - Coronary Heart Disease (American Heart Association) * What Is Coronary Heart Disease? (National Heart ... Coronary Artery Disease Also called: CAD, Coronary arteriosclerosis, Coronary atherosclerosis, Coronary heart disease ... Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States ...
... the authors compare and contrast gout and atherosclerotic cardiovascular disease. What, if anything, do they have in common? ... similar to COLCOT regarding a recent coronary artery disease event with ensuing myocardial ischaemia) and FOURIER (similar to ... colchicine administration for coronary artery disease resembled gout therapy. ... 3]-conceptually combine two diseases, gout and atherosclerotic cardiovascular disease (ASCVD), intuitively considered to be ...
... is a complex disease that causes reduced or absent blood flow in one or more of the arteries that encircle and supply the heart ... encoded search term (Coronary Artery Disease Imaging) and Coronary Artery Disease Imaging What to Read Next on Medscape ... Coronary revascularization is the most important treatment strategy for coronary artery disease. Percutaneous coronary ... Coronary artery disease (CAD) is a complex disease that causes reduced or absent blood flow in 1 or more of the arteries that ...
... ... A 3-year follow-up study of coronary heart disease in Delhi.. ...
2020)‎. Tobacco and coronary heart disease. World Health Organization. ...
... patients with coronary artery disease can manage their condition and lead healthy lives. ... Coronary artery disease (otherwise known as CAD) is the most common type of heart disease in the United States and the leading ... Coronary Artery Disease. Last updated November 1, 2016.. NIH: National Heart, Lung, and Blood Institute. What Is Coronary Heart ... Health Topicsheart healthheart diseaseHeart-Healthy Treatments for Coronary Artery Disease. ...
... including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in ... Infliximab treatment for refractory Kawasaki disease with coronary artery aneurysm Circ J. 2008 May;72(5):850-2. doi: 10.1253/ ... Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery ... aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared ...
How much do you know about type 2 diabetes and coronary heart disease? Test your knowledge with this quick quiz. ... such as coronary heart disease and stroke, and microvascular conditions, such as retinopathy and kidney disease. Such ... Fast Five Quiz: Type 2 Diabetes and Coronary Heart Disease - Medscape - Apr 24, 2023. ... people with type 2 diabetes for cardiovascular risk is an important strategy for reducing mortality and cardiovascular disease ...
Certain aspects of coronary artery disease (CAD) can be different for women compared with men. Heres what you need to know. ... The most common type of heart disease is coronary artery disease (CAD). You might also hear the name coronary heart disease. ... Articles On Risks of Coronary Artery Disease * Risk Factors for Heart Disease ... National Heart, Lung, and Blood Institute: "Coronary Heart Disease.". American Heart Association: "Cardiovascular Disease: ...
The princess has thus become the oldest known case of coronary artery disease. Researchers presented their finding at the ... She could have had inflammation from common parasitic diseases. Or there may be an as yet unknown cause of some cardiovascular ... The mummy scans show that heart disease, considered a result of our modern lifestyle, may not be so modern after all. ... Two of her three main coronary arteries were calcified, a marker of atherosclerosis. Someone in her situation today would have ...
Prehospital misdiagnosis of acute cerebral disease for acute coronary syndrome: a retrospective study.. ... Prehospital misdiagnosis of acute cerebral disease for acute coronary syndrome: a retrospective study. ... Prehospital misdiagnosis of acute cerebral disease for acute coronary syndrome: a retrospective study. ... In cerebrovascular accidents symptoms, laboratory results and electrocardiogram (ECG) changes can mimic acute coronary syndrome ...
There was a suggestion of lower coronary heart disease risk with CEE among women 50 to 59 years of age at baseline. ... Conjugated equine estrogens provided no overall protection against myocardial infarction or coronary death in generally healthy ... Conjugated equine estrogens and coronary heart disease: the Womens Health Initiative Arch Intern Med. 2006 Feb 13;166(3):357- ... There was a suggestion of lower coronary heart disease risk with CEE among women 50 to 59 years of age at baseline. ...
Coronary artery disease (CAD) is the most common type of heart disease. It is caused by a narrowing of the major vessels that ... What is Coronary Artery Disease?. Coronary artery disease (CAD) is the most common type of heart disease. It is caused by a ... This is called atherosclerosis CAD can result in coronary heart disease also called ischemic heart disease. Over time, CAD can ... How is coronary artery disease treated?. You and your cardiologist work together to create your best treatment plan. Your plan ...
In this session, a complex coronary case is presented. All symptoms, patient characteristics and test results are described in ...
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at genome-wide significance (P ... Watkins and colleagues meta-analyze data from the UK Biobank along with recent genome-wide association studies for coronary ... artery disease. They identify 13 new loci that were genome-wide significant and 243 loci at a 5% false discovery rate. ... Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. N. Engl. J. Med. 374, 1134-1144 (2016). ...
... had left main coronary disease, 747 (68%) patients had single vessel disease, 181 (17%) had two-vessel disease and that 155 (14 ... Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by ... or coronary bypass graft (CABG) from 2010 to 2012. Data on demographic features, cardiovascular risk factors, and angiographic ... had three-vessel disease. The most common anatomical involvement was the anterior wall territory. Conclusion: Young CAD ...
Coronary Artery Disease: Should I Have Bypass Surgery?. Heres a record of your answers. You can use it to talk with your ... Have coronary artery bypass surgery Have coronary artery bypass surgery *The surgery can take 3 to 6 hours. You will stay in ... 2.2, Will bypass surgery cure your heart disease?. *. YesSorry, thats not right. Bypass surgery cant cure heart disease. You ... What is coronary artery bypass surgery?. Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
One of the first studies of its kind has found integrated PET/CT to be a highly accurate method for diagnosing coronary artery ... disease. The combined imaging approach can help physicians decide whether to treat these patients with revascularization or ... All patients had been referred for a PET myocardial perfusion scan due to a clinical history of coronary disease. They had ... An average 30% of coronary angiograms yield clinically insignificant disease, and angiography cannot predict the physiologic ...
coronary artery disease Blogs, Comments and Archive News on ... coronary artery disease Latest Breaking News, Pictures, Videos, and Special Reports from The Economic Times. ... Eating food filled with transfat increases the risk of coronary heart disease by clogging the arteries; which is why, FSSAI has ... A higher intake of refined grains can make you vulnerable to premature coronary artery disease. ...
... like coronary heart disease (CHD), angina, myocardial infarction and heart failure, present new challenges for the employer. ... As a result, health problems associated with the aging process, like coronary heart disease (CHD), angina, myocardial ... Improving self-care among aging workers with coronary heart disease: a growing priority.. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary ... p> Relevant updates to the text are sourced regularly from the parent reference, Braunwalds Heart Disease and ... This brand-new companion to Braunwalds Heart Disease was designed as a stand-alone reference for physicians ... Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes ...
Burnout and Risk of Coronary Heart Disease: A Prospective Study of 8838 Employees : Psychosomatic Medicine. ... Burnout and Risk of Coronary Heart Disease. A Prospective Study of 8838 Employees. Toker, Sharon PhD; Melamed, Samuel PhD; ... This study was designed to evaluate prospectively the association between burnout and coronary heart disease (CHD) incidence ... Burnout and Risk of Coronary Heart Disease: A Prospective Study of 8838 Employees ...
Cardiovascular Disease (CVD) Comparable Efficacy of Rivaroxaban Plus Aspirin Regimen Across BMI, Body Weight Categories By ... Rivaroxaban plus aspirin regimen for chronic atherosclerotic vascular disease may not require adjustment based on BMI or weight ... invasive cardiac procedures in patients with advanced chronic kidney disease predicted earlier dialysis initiation. ... Veterans Affairs data to evaluate the association of pre-operative hemoglobin A1c and long-term outcome after isolated coronary ...
Are you at risk of developing coronary heart disease or Alzheimers disease? Find out here. ... Risk Assessment for Coronary Heart Disease and Alzheimers. * Coronary heart disease * Alzheimers disease Risks for Coronary ... Risk factors for coronary heart disease in women*. Major. Intermediate. Minor. known coronary artery disease or peripheral ... family history of coronary artery disease. -. -. psychosocial factors such as poor social support, high stress with low ...
  • Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary arteries). (
  • CAD is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. (
  • Health care professionals can measure blood pressure within the heart and the strength of blood flow through the heart's chambers as well as collect blood samples from the heart or inject dye into the arteries of the heart (coronary arteries). (
  • Monitors blockage and flow of blood through the coronary arteries. (
  • A computed tomography (CT) scan that looks in the coronary arteries for calcium buildup and plaque. (
  • [ 4 ] Coronary angiography uses a contrast material and x-rays to show how blood flows through the coronary arteries. (
  • Coronary artery disease (CAD) is a complex disease that causes reduced or absent blood flow in 1 or more of the arteries that encircle and supply the heart. (
  • The term coronary is derived from crown, referring to the way these arteries sit on the heart. (
  • Coronary artery bypass grafting (CABG) is the most effective revascularization approach for stenotic coronary arteries. (
  • See the images below depicting the coronary arteries and CAD. (
  • Selective injection image of the left coronary arteries. (
  • Lesions that cause blockages in the coronary arteries may be stable or unstable. (
  • Depending on the degree of blockage in your arteries, your doctor or cardiologist may recommend prescription medications, in addition to healthy lifestyle habits, to reduce the effects of coronary artery disease. (
  • Two of her three main coronary arteries were calcified, a marker of atherosclerosis. (
  • Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by decreased left ventricular function. (
  • The surgery doesn't change the way arteries harden or narrow because of heart disease. (
  • Coronary artery disease develops when the major blood vessels ― the coronary arteries ― that supply your heart with blood, oxygen and nutrients become damaged or diseased. (
  • When plaque builds up, it narrows your coronary arteries, decreasing blood flow to your heart. (
  • High stress - unrelieved stress can damage your arteries and worsen other risk factors for coronary artery disease. (
  • He or she may want to test you for coronary artery disease, especially if you have signs or symptoms of narrowed arteries. (
  • Coronary angioplasty is a procedure used to open clogged heart arteries. (
  • Coronary bypass surgery redirects blood around a section of blocked or partially blocked arteries in your heart to improve blood flow to your heart muscle. (
  • Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). (
  • Coronary artery disease develops because of obstruction in your coronary arteries. (
  • It becomes a hindrance when the accumulation of fatty substances blocks a considerable portion of your coronary arteries. (
  • Coronary arteries are the ones that supplies your heart with oxygen-rich blood. (
  • Coronary artery disease is caused by the build-up of plaques inside your arteries. (
  • If you wonder what coronary heart disease is, it inhibits the normal functioning of your heart by building up of plaque in the arteries, the rate at which the plaque gets piled up differs from person to person. (
  • Coronary artery disease (CAD), also called coronary heart disease, is a condition in which plaque (plak) builds up inside the coronary arteries. (
  • Broadly, coronary revascularization is a surgical intervention used to treat blocked arteries. (
  • These arteries are called coronary arteries. (
  • Coronary artery disease (heart disease) happens when blood flow through the coronary arteries is partially or totally blocked. (
  • This report includes final, centrally adjudicated results for the primary efficacy outcome (myocardial infarction or coronary death), secondary coronary outcomes, and subgroup analyses. (
  • Conjugated equine estrogens provided no overall protection against myocardial infarction or coronary death in generally healthy postmenopausal women during a 7-year period of use. (
  • All patients had been referred for a PET myocardial perfusion scan due to a clinical history of coronary disease. (
  • As a result, health problems associated with the aging process, like coronary heart disease (CHD), angina, myocardial infarction and heart failure, present new challenges for the employer. (
  • CHD incidence was defined as a composite of acute myocardial infarction, diagnosed ischemic heart disease, and diagnosed angina pectoris. (
  • FRIDAY, Feb. 26, 2021 (HealthDay News) -- From 2008 to 2017, the rates of recurrent myocardial infarction (MI), recurrent coronary heart disease (CHD) events, heart failure hospitalization, and mortality declined in the year after MI, with greater reductions seen for women than men, according to a study published in the Feb. 16 issue of Circulation . (
  • The cardiologists classified cases as sudden cardiac death (death attributed to coronary artery disease), acute myocardial infarction (typical history and resting electrocardiogram changes and creatine kinase concentrations twice the normal upper limit), unstable angina (typical chest pain at rest or rapidly worsening exertional pain without raised creatine kinase concentrations), or exertional angina (typical history and information from exercise testing or perfusion scanning, which was available in 92% of cases) (table 1). (
  • Considerable potential exists to reduce the risk of recurrent disease and specifically to prevent patients with angina and well preserved ventricular function from progressing to myocardial infarction and death. (
  • The primary outcome of their research was the composite of cardiovascular death, spontaneous myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization. (
  • The incidence of spontaneous myocardial infarction, ischemia-driven coronary revascularization, and cardiovascular death were all significantly lower in the group treated with colchicine. (
  • This study examined whether the peptide NT-proBNP, secreted by myocardial cells in response to increased blood flow and pressure, is useful for detecting ventricular dysfunction in patients with stable coronary heart disease (CHD) and no history of heart failure. (
  • Compared to patients with lower NT-proNB levels, those with higher levels were more likely to be older, white or male, have a history of hypertension, myocardial infarction, or coronary artery grafting. (
  • The death certificate, completed by the county chief deputy coroner, and the autopsy report, completed by the pathologist, listed "cardiac dysrhythmia due to atherosclerotic coronary artery disease and myocardial bridging of anterior descending coronary artery" as the cause of death. (
  • For instance, lipid profiles are well acknowledged to be associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI) [ 1 ]. (
  • The death certificate lists acute myocardial infarction and coronary artery disease as the causes of death. (
  • Was the death specific clinical conditions (i.e. acute myocardial infarction, coronary of this patient expected? (
  • 2] A prediction model that and transparency of such risk adjustment models, and to widen uses a `history of coronary heart disease' as a risk factor to predict discussion on the strengths and limitations of risk adjustment models death from an acute myocardial infarction (AMI) is always going based on service claims data. (
  • An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. (
  • It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. (
  • The evaluation of patients with SIHD includes coronary angiography, which is considered the gold standard for CAD diagnosis. (
  • [ 5 ] Patients in whom SIHD is suspected who have unacceptable ischemic symptoms and who, despite guideline-directed medication therapy, still have persistent ischemic symptoms may benefit from coronary angiography. (
  • Coronary angiography may be able to define the extent and severity of CAD in patients in whom SIHD is suspected. (
  • Coronary angiography may also be beneficial in patients who cannot undergo stress testing or have an indeterminate or nondiagnostic stress test when there is a high likelihood that findings may result in changes to therapy. (
  • Additionally, coronary angiography may be considered in patients with acceptable stress-test results not suggestive of the presence of CAD when clinical suspicion of CAD remains high and the likelihood is great that findings may result in changes to therapy. (
  • Newer technologies such as CT fractional flow reserve, CT angiography with perfusion, and whole-heart coronary magnetic resonance angiography with perfusion, which can provide both anatomic and functional information in the same test, obviate the need for multiple diagnostic tests to obtain a comprehensive assessment of both plaque burden and downstream ischemia. (
  • Standard imaging with coronary angiography is costly compared with alternatives such as CT angiography or intravascular coronary ultrasound. (
  • An average 30% of coronary angiograms yield clinically insignificant disease, and angiography cannot predict the physiologic implications of stenoses such as ischemic recurrence or vessel reocclusion after lytic therapy. (
  • An imaging test that combines functional and anatomic capabilities could render coronary angiography unnecessary. (
  • They had previously undergone coronary angiography for recurrent chest pain. (
  • The investigators compared PET/CT with PET plus coronary angiography. (
  • In A, coronary angiography showed 80% stenosis of the mid-left anterior descending artery (red arrow), chronic total occlusion of the left circumflex artery (white arrow), and in B, mild to moderate diffuse atherosclerosis of the right coronary artery (arrows). (
  • The "Korea Presents" session, "Exploring Evidence in Cardiovascular Imaging," will explore the imaging assessment of cardiovascular risk factors in stroke, coronary CT screening angiography, and the results of a multicenter trial comparing CT stress perfusion imaging to fractional flow reserve imaging for assessing ischemic heart disease. (
  • This is called atherosclerosis CAD can result in coronary heart disease also called ischemic heart disease. (
  • Objective: Due to devastating consequences of coronary artery disease (CAD) in young population, this study was designed to evaluate the prevalence of preventable risk factors and severity of atherosclerosis for Iranian young adults (≤45 years) diagnosed with premature CAD. (
  • 1 Subsequently, autopsy studies suggested that deep bilateral earlobe creases could be an important sign of coronary atherosclerosis. (
  • The surgeon connects, or grafts, a healthy blood vessel from another part of your body to the narrowed coronary artery. (
  • This allows blood to flow around the blocked or narrowed coronary artery. (
  • Percutaneous coronary intervention (PCI) has become the most frequently performed procedure. (
  • Method: A cross sectional, descriptive study comprised 1093 consecutive patients (≤45 years), with a diagnosis of CAD, who underwent percutaneous intervention (PCI) or coronary bypass graft (CABG) from 2010 to 2012. (
  • This dual antiplatelet therapy (DAPT) is still indicated for secondary coronary prevention after either an acute coronary syndrome (ACS) or a planned percutaneous coronary intervention (PCI). (
  • Previous models for contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) include procedure-related variables in addition to pre-procedural variables. (
  • These patients must be amenable to and qualify for coronary revascularization and have undergone noninvasive testing, excluding stress tests indicating a high likelihood of severe IHD. (
  • Coronary revascularization is the most important treatment strategy for CAD. (
  • Multidisciplinary decision-making should analyze current evidence, consider the clinical condition of the patient, and determine the safety of and necessity for coronary revascularization with either PCI or CABG. (
  • The hybrid coronary revascularization approach combines the "gold standard of cardiac surgery"-the single arterial bypass-with stenting for the rest of the vessels, Chikwe said. (
  • The alternate route is the multiarterial coronary revascularization method, which is ideal for severe coronary artery disease patients who are younger than 65 and have otherwise healthy hearts. (
  • Part of the reason that many medical centers have been slow to adopt the multiarterial coronary revascularization method is it requires an intense technical demand on the surgeon, and additional expertise on the rest of the surgery team-especially to perform it as safely as conventional bypass operations. (
  • In recent randomized trials, conjugated equine estrogens (CEE) with continuous medroxyprogesterone acetate provided no protection against coronary heart disease in postmenopausal women and may have increased cardiac risk. (
  • Guthrie Cardiac and Vascular team treats patients with circulatory diseases: abdominal aortic aneurysm, carotid artery disease, and peripheral artery disease. (
  • In a post hoc analysis of data from the ISCHEMIA-CKD trial, invasive cardiac procedures in patients with advanced chronic kidney disease predicted earlier dialysis initiation. (
  • If this is the case, usually there is no further coronary heart disease diagnostic work-up unless no other non-cardiac cause is suspected or unless there is a high level of concern on the part of the physician or woman. (
  • This supports the potential benefits of anti-inflammatory therapies in patients with coronary disease, however, the unexpected rise in non-cardiac deaths is a concern that requires further investigation to assess the risk-to-benefit ratio of using colchicine in this demographic. (
  • The cardiac veins collect blood containing waste products from the heart muscle and empty it into a large vein on the back surface of the heart called the coronary sinus, which returns the blood to the right atrium. (
  • Given the Chief's underlying coronary heart disease, NIOSH investigators concluded that the physical stress of performing physical fitness training may have triggered a cardiac arrhythmia and a possible heart attack resulting in his sudden cardiac death. (
  • In procedures where the aortic valve replacement (AVR) is combined with a coronary artery bypass graft (CABG), the use of a rapid deployment valve can shorten the duration of cardiac ischemia and the overall intervention duration, which possibly has an influence on clinical results. (
  • It is sometimes called coronary heart disease or ischemic heart disease. (
  • 22 ]. The overall prevalence of ischemic ble burden of high risk factors such as obe- heart diseases in men was 2.3% in the rural sity and hypercholesterolemia and mal- and 4.7% in the urban populations and cor- nutrition and hypocholesterolaemia [ 2 ]. (
  • Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared with those without. (
  • Angiographic study revealed that 10 (1%) had left main coronary disease, 747 (68%) patients had single vessel disease, 181 (17%) had two-vessel disease and that 155 (14%) had three-vessel disease. (
  • This study reported more severe disease outcomes in patients with hypertension. (
  • For example, patients with CHD should adhere to complex medication regimens, follow low sodium/low fat diets, and routinely monitor for early signs of disease (self-care maintenance). (
  • This patient's presentation and evaluation remind us that bilateral earlobe creases may be useful to include in the clinical examination of patients with suspected coronary artery disease and may facilitate early recognition of disease in a patient at high risk. (
  • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease. (
  • The effect of pravastatin on coronary events after MI in patients with average cholesterol levels. (
  • Research has shown that the compound may prevent conditions caused by inflammation, including several cardiometabolic diseases, however, evidence of its efficacy in risk reduction in patients with chronic coronary disease remains limited. (
  • Published in the New England Journal of Medicine, the study evaluated the potential for the medication to reduce the risk of adverse cardiovascular events in patients with chronic coronary disease. (
  • Led by Stefan M. Nidorf, MD, FACC, a team of researchers conducted a randomized, controlled, double-blind study in which patients with chronic coronary disease were either assigned 0.5 mg of colchicine to be taken once daily or a placebo medication. (
  • An international expert in cardiovascular surgery with specific expertise in coronary vascularization, Chikwe is a leader in advancing the surgical technique to improve the lives of patients with severe coronary artery disease. (
  • That's a really important contribution to helping patients with coronary disease get treatment that will last them longer than anything else we know in medicine,' Chikwe said. (
  • According to Professor Claes Ohlsson, "While the study establishes a clear correlation between DHEA in the blood and coronary heart disease , the discovery does not indicate whether or not treatment with DHEA will reduce the risk in individual patients. (
  • T]his [defective] macrophage is predisposed to go haywire because it's got a sweet tooth: Coronary artery disease patients' macrophages tend to suck up far more glucose from the blood stream than they should. (
  • Patients with coronary artery disease (CAD) presenting with acute coronary syndrome or undergoing coronary stenting are indicated to treatment with dual antiplatelet therapy (DAPT) combining aspirin with a P2Y12 receptor inhibitor. (
  • The complexity of antiplatelet therapy in CAD patients is due to the fact that this complexity embraces several aspects: the coronary anatomy, the number of vascular districts at risk for atherothrombosis, and patient comorbidities, including global frailty. (
  • [ 1-5 ] Aspirin, in combination with an oral P2Y12 receptor inhibitor (i.e. clopidogrel, prasugrel, or ticagrelor), remains the cornerstone of treatment for patients with coronary artery disease (CAD). (
  • We also report on ongoing trials focusing on interventional strategies to optimize the long-term management of coronary patients. (
  • Moreover, the risk of coronary artery disease is increased in presence of cyclophilin B levels above 63.26 pg/mL and with hypertension or dyslipidemia in male patients . (
  • Consequently, cyclophilins A and C serum levels are reinforced as useful coronary artery disease biomarkers , meanwhile, cyclophilin B is a valuable biomarker in the male population when patients are also suffering from hypertension or dyslipidemia . (
  • Depression occurs frequently in patients with coronary artery disease (CAD) and is associated with a poor prognosis. (
  • Although it may be unusual for clinicians to encounter newly diagnosed patients with high-grade prostate cancer metastatic to the bone, researchers have noted an increase in patients presenting with high-risk disease since the US Preventive Services Task Force changed its recommendations on prostate cancer screenings, 1 noted Joseph F. Renzulli, II, MD, FACS . (
  • 2 The benefit was more pronounced in patients with high-volume disease. (
  • Despite the widespread recognition of pyuria in acute Kawasaki disease (KD) patients and its inclusion in the American Heart Association list of supporting laboratory data for KD diagnosis, no systematic study of pyuria and the origin of these cells in KD patients have been reported. (
  • This article is intended for clinicians who want to maintain a current understanding of recent research and evidence in decision making for predicting cardiovascular events in patients at risk for coronary events. (
  • Describe the relevance of the findings to clinicians in the care of their patients at risk for coronary events. (
  • Apart from rare congenital anomalies (birth defects), coronary artery disease is usually a degenerative disease, uncommon as a clinical problem before the age of 30 years and common by the age of 60 years. (
  • Strategies to reduce deaths from coronary heart disease need to take into account clinical presentation of the disease. (
  • A growing number of people are currently suffering from a range of major clinical heart and circulatory disease conditions, including coronary artery disease (CAD), heart failure, peripheral arterial disease, and cerebrovascular disease [ 1 ]. (
  • Due to the proinflammatory effects and various studies, which had illustrated that the Lp-PLA2 was correlated with a wide range of cardiovascular diseases [ 9 - 11 ], Lp-PLA2 is gradually identified as a reliable biomarker for the risk of clinical cardiovascular events. (
  • Any history of coronary artery bypass surgery, coronary artery stenting, or clinical diagnosis of coronary artery disease according to the electronic medical record. (
  • Several clinical parameters are associated with common diseases and are helpful for predicting and preventing these common diseases. (
  • The FDA evaluated results from seven small clinical studies that evaluated the relationship between consumption of oils containing high levels of oleic acid (at least 70 percent per serving) and improved cholesterol levels, which indicates a reduced risk for coronary heart disease. (
  • Although timely diagnosis and treatment with intravenous immunoglobulin (IVIG) are critical to reduce the incidence of coronary artery aneurysms, 8 diagnosis of KD is still established based on clinical criteria supported by laboratory evidence of acute inflammation and there is no specific diagnostic test to aid the clinician. (
  • Clinical studies have shown that there is an association between the history of coronary artery disease (CAD) and dementia, notably vascular dementia (DV). (
  • Cipla said, Metoprolol succinate extended-release tablets are indicated for the treatment of hypertension, to lower blood pressure, Angina Pectoris (chest pain or discomfort due to coronary heart disease). (
  • Introduction: An estimated seven million American adults live with coronary artery disease and chronic angina. (
  • Unstable Angina) Acute coronary syndromes result from a sudden blockage in a coronary artery. (
  • What are the risks for coronary artery disease? (
  • What causes coronary artery disease? (
  • Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. (
  • A 3-year follow-up study of coronary heart disease in Delhi. (
  • She has no history of coronary artery disease, diabetes mellitus, or pulmonary disease. (
  • Despite concern about the incidence of coronary heart disease (CHD) in people with severe mental illness (SMI), there is little systematic research on CHD risk factors in this population. (
  • Centers for Disease Control and Prevention. (
  • Smoking is the leading preventable cause of death in the United States, resulting in more than 480,000 deaths - about one in five deaths - each year, according to the U.S. Centers for Disease Control. (
  • In a Centers for Disease Control (CDC) study published in JAMA , the number of respondents reporting that smoking was not allowed in public or work areas at their companies increased from 46.5 percent in 1992-93 to 63.7 percent in 1995-96. (
  • It is important to know what the risk factors are for coronary heart disease so that women are more likely to have the recommended diagnostic studies and thus earlier diagnosis. (
  • [ 2 ] ), and heart disease continues to be the leading cause of death for women in the United States, accounting for more deaths in women than all forms of cancer, chronic lower respiratory disease, and diabetes mellitus combined. (
  • According to the results of questionnaire and electrocardiogram, all subjects were free of hypertension, hyperlipemia, cardiovascular disease, and diabetes mellitus. (
  • Two types of obesity are distinguished with respect to their risk for eventual heart disease. (
  • Type 2 diabetes and coronary artery disease share similar risk factors, such as obesity and high blood pressure. (
  • If you have risk factors for coronary artery disease, such as high blood pressure, high cholesterol, tobacco use, diabetes, a strong family history of heart disease or obesity, talk with one of Mayo Clinic Health System's Cardiology providers. (
  • IMSEAR at SEARO: Obesity and coronary disease. (
  • Obesity and coronary disease. (
  • Looking forward, major challenges include stemming the obesity and chronic disease epidemics, addressing health inequities, and diversifying the workforce. (
  • The growing obesity epidemic and the comorbidities associated with it, including insulin resistance, cardiovascular disease, and cancer, have made adipose tissue an important subject of scientific study and a target of therapeutic interventions. (
  • The preva- past 3 decades in Pakistan the incidence of lence of hypertension was 16.3% in men coronary heart disease (CHD) has in- and 20.4% in women in the rural communi- creased [ 2-15 ]. (
  • The multivariate analysis strengthens the predictive value for coronary artery disease presence of cyclophilin A (>8.2 ng/mL) and cyclophilin C (>17.5 pg/mL) along with the cardiovascular risk factors tobacco , hypertension , dyslipidemia , and high glucose and cholesterol levels. (
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (
  • What are the symptoms of coronary artery disease? (
  • If you're at high risk for heart disease or already have symptoms, your doctor can use several tests to diagnose CAD. (
  • Pain and tightness in the chest are common symptoms of coronary artery disease, but many prescription medications can offer relief. (
  • But certain aspects of the disease, like the risk factors and symptoms, can be different for you. (
  • Many women don't have symptoms of coronary artery disease, or they're different from the "classic" ones that men have. (
  • In cerebrovascular accidents symptoms, laboratory results and electrocardiogram (ECG) changes can mimic acute coronary syndrome (ACS) and is subsumed as neurogenic stunned myocardium. (
  • Coronary artery disease develops over decades and may have no symptoms. (
  • Eventually, the decreased blood flow may cause chest pain, shortness of breath, or other coronary artery disease signs and symptoms. (
  • When the first symptoms of erectile dysfunction occur, the doctor should not just prescribe the little blue pill (Viagra), but should carefully check for coronary heart disease (CHD). (
  • In many cases, coronary artery disease symptoms develop only at later stages. (
  • Coronary artery disease symptoms may take years to develop. (
  • It is also a common misconception that, since it is heart disease, its symptoms arise only in and around your heart. (
  • 2020)‎. Tobacco and coronary heart disease. (
  • Guthrie Robert Packer Hospital was named among the top 10% in the nation for coronary interventional procedures for 5 years in a row (2016-2020) by Healthgrades. (
  • Risk factors for coronary heart disease are generally divided into minor, intermediate and major. (
  • 2 Diagonal earlobe creases have been shown to be independently associated with increased prevalence, extent, and severity of coronary artery disease. (
  • With chronic disease prevalence growing at a faster rate than the population as a whole, the forecast is daunting. (
  • Rivaroxaban plus aspirin regimen for chronic atherosclerotic vascular disease may not require adjustment based on BMI or weight. (
  • Doctors don't have a high index of suspicion when a woman presents with chest pain because most of the time it is due to causes other than atherosclerotic coronary heart disease. (
  • 5 The mechanism linking diagonal earlobe creases and atherosclerotic disease is not yet clear. (
  • CVD outcomes included death and hospitalisations for ischaemic heart disease, heart failure, cerebrovascular disease, peripheral artery disease or aortic aneurysm. (
  • The right coronary artery and the left coronary artery, which branch off the aorta just after it leaves the heart, deliver oxygen-rich blood to the heart muscle. (
  • The right coronary artery branches into the marginal artery and the posterior interventricular artery, located on the back surface of the heart. (
  • Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood flow to the heart in people with severe coronary artery disease . (
  • Performance could be further improved by using summary risk prediction scores such as the EUROSCORE II for coronary artery bypass graft surgery or the GRACE risk score for acute coronary syndrome. (
  • Primordial prevention usually refers to healthy lifestyle choices to prevent the development of coronary risk factors. (
  • A study by Pande et al suggests millions of US adults with peripheral arterial disease (PAD) are not receiving secondary prevention therapies. (
  • A new study about the importance of fiber was confirmed for the prevention of major diseases. (
  • This supplement to The American Journal of Cardiology presents the proceedings of the Summit on Cholesterol and Coronary Disease: Second National Conference on Lipids in the Elimination and Prevention of Coronary Artery Disease presented by the Cleveland Clinic Foundation in cooperation with the Walt Disney Company in Lake Buena Vista, Florida, September 4-5, 1997. (
  • Western Diseases-Their Dietary Prevention and Reversibility. (
  • Each of us has a unique body chemistry which responds differently to disease, drugs, foods, allergies, prevention, exercise, and every other criterion you can think of. (
  • Coronary heart disease : the scope for prevention / by Nicholas Wells. (
  • The present systematic review provides no evidence for the beneficial effects of reduced/modified fat diets in the secondary prevention of coronary heart disease. (
  • The most recent ESC guidelines on cardiovascular disease (CVD) prevention suggest that there is a fixed relationship between CVD mortality and the total burden of CVD events, defined as the composite of fatal and non-fatal CVD. (
  • Guidance on self-care interventions aimed at four shared risk factors - tobacco use, physical inactivity, unhealthy diets and the harmful use of alcohol are addressed in the 2008-2013 action plan for the global strategy for the prevention and control of non-communicable diseases. (
  • A number of risk factors contribute to the development of coronary artery disease. (
  • D1 = first diagonal, LAD = left anterior descending artery, LCX = left circumflex, LM = left main coronary artery, and OM1= first obtuse marginal. (
  • The left coronary artery (typically called the left main coronary artery) branches into the circumflex and the left anterior descending artery. (
  • Urgent coronary arteriography showed severe coronary artery disease ( Figure 2 ). (
  • Despite relatively recent declines in age-adjusted mortality, in 2013, cardiovascular disease (CVD) was the primary cause in nearly 801,000 deaths (30.8% of total deaths) in the United States. (
  • Approximately 85.6 million Americans suffer from some form of cardiovascular disease (CVD) and close to 1 in 3 deaths result from CVD. (
  • In high-income countries, coronary artery disease is the leading cause of death in both men and women, accounting for about one third of all deaths. (
  • secondhand smoke contains about 70 cancer-causing chemicals and leads to nearly 42,000 premature deaths from heart disease and lung cancer each year in the United States, the CDC says. (
  • The CDC also estimates that 62,000 coronary heart disease deaths annually among nonsmokers are due to their exposure to ETS. (
  • Because coronary artery disease often develops over decades, you may not notice a problem until you have a significant blockage or a heart attack. (
  • Complications associated with diabetes include macrovascular conditions, such as coronary heart disease and stroke, and microvascular conditions, such as retinopathy and kidney disease. (
  • These are not only deadly but costly diseases with CVD and stroke costing around $320 billion each year. (
  • It increases the rate of coronary heart disease, stroke and lung cancer and contributes to many other health issues. (