Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The circulation of blood through the CORONARY VESSELS of the HEART.
Narrowing or constriction of a coronary artery.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The vessels carrying blood away from the heart.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Spasm of the large- or medium-sized coronary arteries.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Pathologic deposition of calcium salts in tissues.
Elements of limited time intervals, contributing to particular results or situations.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Drugs used to cause dilation of the blood vessels.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The hollow, muscular organ that maintains the circulation of the blood.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Pressure, burning, or numbness in the chest.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
The main artery of the thigh, a continuation of the external iliac artery.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The arterial blood vessels supplying the CEREBRUM.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Motion pictures of the passage of contrast medium through blood vessels.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Lesions formed within the walls of ARTERIES.
Radiography of blood vessels after injection of a contrast medium.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
The condition of an anatomical structure's being constricted beyond normal dimensions.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Conditions with excess LIPIDS in the blood.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Substances used to allow enhanced visualization of tissues.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
The nonstriated involuntary muscle tissue of blood vessels.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The transference of a heart from one human or animal to another.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Contractile activity of the MYOCARDIUM.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Diseases that do not exhibit symptoms.
The return of a sign, symptom, or disease after a remission.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Radiography of the heart and great vessels after injection of a contrast medium.
The vein which drains the foot and leg.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The condition of an anatomical structure's being dilated beyond normal dimensions.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
The flow of BLOOD through or around an organ or region of the body.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Substances used to lower plasma CHOLESTEROL levels.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Examinations used to diagnose and treat heart conditions.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Obstruction of flow in biological or prosthetic vascular grafts.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Formation and development of a thrombus or blood clot in the blood vessel.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Constitutional, biochemical and lifestyle correlates of fibrinogen and factor VII activity in Polish urban and rural populations. (1/8418)

BACKGROUND: Fibrinogen and factor VII activity are known to be related to atherosclerosis and coronary heart disease, but population differences in clotting factors and modifiable characteristics that influence their levels have not been widely explored. METHODS: This paper examines correlates of plasma fibrinogen concentration and factor VII activity in 2443 men and women aged 35-64 in random samples selected from the residents in two districts in urban Warsaw (618 men and 651 women) and from rural Tarnobrzeg Province (556 men and 618 women) screened in 1987-1988, and assesses which characteristics might explain urban-rural differences. Fibrinogen and factor VII activity were determined using coagulation methods. RESULTS: Fibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw. Factor VII activity was higher in Warsaw (9.2% in men and 15.3% in women). After adjustment for selected characteristics, fibrinogen was higher in smokers compared to non-smokers by 28 mg/dl in men and 22 mg/dl in women. In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P < 0.01). After adjustment for other variables, a higher factor VII activity in Warsaw remained significant (a difference of 9.4% in men and 14.8% in women). Lower fibrinogen in Warsaw remained significant only in women (15.4 mg/dl difference). CONCLUSIONS: The study confirmed that sex, age, BMI, smoking and blood lipids are related to clotting factors. However, with the exception of gender differences and smoking, associations between clotting factors and other variables were small and of questionable practical importance.  (+info)

Combined carotid endarterectomy and coronary artery bypass graft. (2/8418)

Atherosclerosis is a generalized disease which afflicts a considerable number of patients in both the carotid and coronary arteries. Although the risk of stroke or death use to combined carotid endarterectomy (CEA) and coronary artery bypass graft (CABG) is thought to be higher than that of each individual operation, the combined procedure is generally preferred over staged operations to treat such patients. We performed the combined procedure safely with the aid of intraoperative portable digital subtraction angiography (DSA). This report describes our experience with the operative strategy of simultaneous CEA and CABG. Ninety CEA and 404 CABG were carried out between January 1989 and December 1997. A total of six patients received the combined procedure with the aid of intraoperative DSA; they were studied retrospectively. Postoperative mortality and morbidity after the combined procedure was 0%. In the combined procedure, neurological complications are difficult to detect after CEA because the patient must be maintained under general anesthesia and extracorporeal circulation during the subsequent CABG. However, intraoperative DSA can confirm patency of the internal carotid artery and absence of flap formation after CEA, and the CABG can be performed safely. Intraoperative portable DSA between CEA and CABG is helpful in preventing perioperative stroke in the combined procedure.  (+info)

Macroscopic distribution of coronary atherosclerotic lesions in cholesterol-fed rabbits. (3/8418)

In the present study we macroscopically examined a change in the distribution of coronary atherosclerosis in cholesterol-fed rabbits. Rabbits were fed a cholesterol-enriched diet for 15 weeks, then replaced by a normal diet, and were sacrificed at 15, 24, 32 and 42 weeks after the start of the experiment. The coronary atherosclerosis in the cholesterol-fed rabbits was distributed more densely in the proximal portion than in the middle and distal portions, and the lesions were severe at 24 and 32 weeks after the start of the experiment. comparison of lesions in the three portions at these time points showed that the percentages of lesion areas in the proximal portion, the middle portion and the distal portion were approximately 51%, 21 to 25% and 0.2 to 3.7%, respectively. Macroscopic observation of the coronary atherosclerotic lesions showed that the lesions formed over the vessel lumen in the proximal portion within the range of approximately 5 mm from the orifice of the left coronary artery. In the middle portion, the lesions formed predominantly around the orifices of branches as small patchy lesions from 1 to 3 mm in diameter. These findings support previous histopathological reports that suggested that the incidence of stenosis in the proximal portion was high, and the incidence of lesion occurrence in the middle and the distal portions varied. The method, macroscopical investigation of the coronary artery, is useful for analyzing coronary atherosclerosis in the rabbit.  (+info)

Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. (4/8418)

To investigate the pathogenesis of hyperlipidemia-induced atherosclerosis, we examined age-dependent changes in platelet activity, blood coagulation and fibrinolysis in susceptibility to a high cholesterol diet (HCD) feeding in male ICR mice. Pretreatment of platelet-rich-plasma from HCD feeding mice for 3 days with epinephrine (300 microM) resulted in a marked enhancement of adenosine 5'-diphosphate (ADP: 0.1 microM) or collagen (0.7 microgram/ml)-stimulated aggregation compared with the same in control mice. Yohimbine as alpha 2-adrenergic blocker antagonized these aggregations in a dose-dependent manner. A significant increase in plasma total cholesterol and VLDL (very low-density lipoprotein)-LDL (low-density lipoprotein)-cholesterol and the liver/body weight ratio was observed in mice fed on HCD for 3 months (3-month HCD mice). In the early phase of this experiment, a significant increase in fibrinogen was observed. In the middle phase, increases in the activity of antithrombin III (ATIII) and alpha 2-plasmin inhibitor (alpha 2-Pl) followed. Plasminogen content gradually decreased in both normal diet and HCD mice throughout the experiment. The activity of plasminogen activator inhibitor (PAI) decreased in 3-month HCD mice. Morphological observation of the aortic arch from 3-month HCD mice revealed apparent atheromatous plaques not seen in control mice. These results suggest that 3-month HCD mice can be a convenient hyperlipidemia-induced atherosclerotic model and the changes in platelet activity, coagulation and fibrinolysis in the early phase may be a cause of pathologic changes in this model.  (+info)

2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: role of glycoxidation and lipoxidation reactions in vascular tissue damage. (5/8418)

We have pursued the hypothesis that the carbonyl modification of proteins by glycoxidation and lipoxidation reactions plays a role in atherogenesis. Human atherosclerotic tissues with fatty streaks and uremic arteriosclerotic tissues were examined, with specific antibodies, to detect protein adducts formed with carbonyl compounds by glycoxidation or lipoxidation reactions, i.e. advanced glycation end products (AGEs) or glycoxidation products, such as carboxymethyllysine (CML) and pentosidine, and lipoxidation products, such as malondialdehyde (MDA)-lysine and 4-hydroxy-nonenal (HNE)-protein adduct. All the four adducts were identified in the proliferative intima and in macrophage-rich fatty streaks. If the carbonyl modification is not a mere result but is a contributor to atherogenesis, inhibition of glycoxidation and lipoxidation reactions might prevent vascular tissue damage. We tested this hypothesis in rats following balloon injury of their carotid arteries, a model exhibiting a remarkable intimal thickening, which are stained positive for all the four adducts. Oral administration of 2-isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanili de (OPB-9195), an inhibitor of both glycoxidation and lipoxidation reactions, in rats following balloon injury effectively prevented the intimal thickening. These data suggest a role for the carbonyl modification of proteins by glycoxidation and lipoxidation reactions in most, if not all, types of vascular tissue damage ('carbonyl stress'), and the usefulness of inhibitors of carbonyl reactions for the treatment of vascular tissue damage.  (+info)

Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. (6/8418)

BACKGROUND: Elevated blood concentrations of total homocysteine (tHcy) have been implicated in the pathogenesis of atherosclerotic cardiovascular disease. Previous studies identified suboptimal nutritional status and dietary intake of folate, vitamin B-6, and vitamin B-12 as determinants of elevated tHcy. OBJECTIVE: We identified other nutritional factors associated with tHcy in 260 retired schoolteachers in the Baltimore metropolitan area. DESIGN: We performed observational analyses of baseline and 2-4-mo follow-up data collected in a study designed to test the feasibility of conducting a large-scale clinical trial of vitamin supplements by mail. The study population consisted of 151 women and 109 men with a median age of 64 y. At baseline, each participant completed a food-frequency questionnaire. At follow-up, fasting serum tHcy was measured. RESULTS: In multivariable linear regression and generalized linear models, there was an independent, inverse dose-response relation between dietary protein and In tHcy (P = 0.002) and a positive, significant dose-response relation between coffee consumption and In tHcy (P for trend = 0.01). Other significant predictors of In tHcy were creatinine (positive; P = 0.0001) and prestudy use of supplemental B vitamins (inverse; P = 0.03). In stratified analyses restricted to persons receiving standard multivitamin therapy, the association of 1n tHcy with dietary protein and coffee persisted. CONCLUSIONS: These results support the hypothesis that increased protein intake and decreased coffee consumption may reduce tHcy and potentially prevent atherosclerotic cardiovascular disease and other disease outcomes.  (+info)

Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque. (7/8418)

BACKGROUND: Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human coronary atherosclerotic plaques. METHODS AND RESULTS: Immunohistochemical staining and in situ hybridization demonstrated minimal and random expression of TN-C in fibrotic but lipid-poor atherosclerotic plaques. In contrast, all plaques with an organized lipid core or ruptured intimal surface strongly expressed TN-C, which was preferentially concentrated around the lipid core, shoulder regions, and ruptured area of the plaques but not in the fibrous cap. TN-C was not detected in normal arterial tissue. To identify the cellular source of TN-C, the plaques were stained with smooth muscle cell- and macrophage-specific antibodies. TN-C expression correlated with the infiltration of macrophages. Northern blot and immunoprecipitation analysis showed that macrophages expressed 7. 0-kb TN-C mRNA and 220-kDa protein. Reverse transcription-polymerase chain reaction of total RNA derived from macrophages showed that they express the small isoform of TN-C. Zymogram analysis revealed that macrophages markedly increased MMP-9 expression. CONCLUSIONS: This study demonstrates that the level of TN-C expression correlates with the degree of inflammation present, not with plaque size. In addition, cultured macrophages have the capacity to express the TN-C gene. These findings suggest the significance of macrophages in the remodeling of atherosclerotic plaque matrix composition.  (+info)

Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty. (8/8418)

BACKGROUND: Restenosis is a common problem after all revascularization procedures in atherosclerotic coronary arteries. Reactivated human cytomegalovirus (CMV) has been detected in tissues of restenotic vascular lesions and was hypothesized to be a contributing pathogenic factor. Recent data suggest an association of restenosis after optimal coronary atherectomy with CMV serostatus, and a possible role of antiviral therapy was discussed. We therefore tested the hypothesis that prior CMV infection might be a risk factor for restenosis after conventional coronary balloon angioplasty (PTCA). METHODS AND RESULTS: We analyzed 92 consecutive patients who had been admitted for control angiography after previous PTCA within a mean interval of 6 months. Anti-CMV antibodies were measured as an indicator of prior CMV infection and latency. The coronary angiograms before PTCA, directly after, and 6 months later were analyzed quantitatively. Sixty-five percent of the patients were CMV-positive. Before PTCA, the degree (mean+/-SD) of stenosis was 69+/-10% in CMV-positive and 68+/-8.3% in CMV-negative subjects. PTCA resulted in a residual stenosis of 39% in both groups. After 6 months, the late losses of luminal diameter in the CMV-positive and -negative groups were 11+/-13% and 12+/-15%, respectively (P=0.658). In an ANCOVA with 25 potential risk factors for restenosis, CMV serostatus was not significantly associated with restenosis development. CONCLUSIONS: Our data indicate that prior CMV infection, in contrast to optimal atherectomy, is not associated with chronic restenosis after conventional coronary balloon angioplasty. The results do not support a possible benefit from antiviral therapy.  (+info)

Background: Coronary artery disease is sometimes associated with chronic conduction block. Our aim is to correlate between chronic conduction block and coronary artery disease. We performed ECG and coronary angiography of all patients who were admitted for permanent pacemaker implantation to find correlation between them. Methods: Coronary angiography was performed in all 160 patients of chronic conduction block during twenty four months of study period who were admitted for pacemaker implantation. We compared the coronary artery disease in different types of conduction block. Results: Among the study population 35(22%) patients are of single vessel coronary artery disease (CAD),13 (8%) patients had double vessel coronary artery disease, 6 (4%) patients had triple vessel coronary artery disease, 2 (1%) patients had left main disease and 104 (65%) patients had normal or insignificant coronary anatomy. Conclusion: Coronary artery disease is quite common in chronic conduction disorder. So there ...
Table of Contents. Table of Contents 2. List of Tables 8. List of Figures 9. Introduction 10. Global Markets Direct Report Coverage 10. Coronary Artery Disease (CAD) (Ischemic Heart Disease) Overview 11. Therapeutics Development 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Overview 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Comparative Analysis 13. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Development by Companies 14. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Investigation by Universities/Institutes 17. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Pipeline Products Glance 18. Late Stage Products 18. Clinical Stage Products 19. Early Stage Products 20. Unknown Stage Products 21. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under Development by Companies 22. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under ...
Vasc Health Risk Manag. 2014 Jan 21;10:55-62. doi: 10.2147/VHRM.S53557. eCollection 2014.. Roed T1, Kristoffersen US2, Knudsen A3, Wiinberg N4, Lebech AM1, Almdal T5, Thomsen RW6, Kjær A2, Weis N7.. Abstract. OBJECTIVE: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.. METHODS: Sixty patients with chronic hepatitis C (mean age 51 years) were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.. RESULTS: ...
Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...
TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...
Coronary artery disease is a condition in which the coronary arteries are narrowed by deposits called plaques.. The coronary arteries originate from the aorta and supply blood and oxygen to your heart muscle allowing it pump blood to the body. Normal coronary arteries allow blood to flow freely. However, these arteries can become narrowed by inflammatory fatty deposits called plaques. This disease process is called atherosclerosis. Atherosclerosis that occurs in the coronary arteries is called coronary artery disease.. These plaques build up over time and can decrease the amount of oxygen reaching your heart. Mild coronary artery disease may develop over decades without any symptoms. More severe coronary artery disease can cause chest pain, called angina, and shortness of breath.. If a plaque suddenly ruptures, a blood clot can form and block the hearts blood supply. This is called a heart attack and it can cause permanent damage to the heart. Over time, severe coronary artery disease can also ...
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was
TY - JOUR. T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the framingham risk score. AU - Konstantinou, Dimitris M.. AU - Chatzizisis, Yiannis S.. AU - Louridas, George E.. AU - Giannoglou, George D.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Background: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individuals 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. Methods: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic ...
Coronary artery disease is among the most common causes of disability and death. Often, by the time symptoms occur, the process may already be far advanced. Frequently,t he first symptom of coronary artery disease is heart attack and sudden death. Dangerous coronary artery disease may be present in individuals that are totally asymptomatic. A recent study showed that a family history of early-onset coronary artery disease (CAD) is associated with significant amounts of plaque in the coronary arteries apparently healthy patients.. Researchers demonstrated a significant amount of plaque present (coronary plaque burden) in apparently healthy middle-aged close relatives of individuals with early-onset of coronary artery disease. This study underscores the fact that asymptomatic patients may benefit from early cardiac screening and that is especially true for individuals with a family history of early-onset CAD may benefit from screening for subclinical atherosclerosis.. The Cardiac portion of the ...
OBJECTIVES: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD. BACKGROUND: Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability. METHODS: We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects. RESULTS: We first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n
TY - JOUR. T1 - Internal pudendal artery stenoses and erectile dysfunction. T2 - Correlation with angiographic coronary artery disease. AU - Rogers, Jason H. AU - Karimi, Houshang. AU - Kao, John. AU - Link, Daniel P. AU - Javidan, Javid. AU - Yamasaki, Dwayne S.. AU - Dolan, Mark. AU - Laird, John R.. AU - Low, Reginald. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. Methods: Ten patients undergoing cardiac catheterization with ED and a history of unsatisfactory response to a PDE5i were studied. ED severity was quantified using the International Index of ED scoring system. We performed angiography ...
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Archbold Hosts Health Talk on Coronary Artery Disease Wednesday, February 11, 2015 Coronary artery disease, also known as coronary heart disease...
Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45-79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex and enrollment time. PON1-activity was similar in cases and controls (60.7 +/- 645.3 versus 62.6 +/- 645.8 U/L, p = 0.3) and correlated with HDL-cholesterol levels (r = 0.16, p , 0.0001). The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict ...
The Coronary Artery Disease Treatment Devices market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. The global Coronary Artery Disease Treatment Devices market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global Coronary Artery Disease Treatment Devices market. The report focuses on well-known providers in the global Coronary Artery Disease Treatment Devices industry, market segments, competition, and the macro environment. Under COVID-19 Outbreak, how the Coronary Artery Disease Treatment Devices Industry will develop is also analyzed in detail in Chapter 1.7 of the report. In Chapter 2.4, we analyzed industry trends in the context of COVID-19. In Chapter 3.5, we analyzed the impact of COVID-19 on the product industry chain based on the upstream and downstream markets. In Chapters 6 to 10 of the
Definition of coronary artery disease in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is coronary artery disease? Meaning of coronary artery disease as a finance term. What does coronary artery disease mean in finance?
TY - JOUR. T1 - Cardiocirculatory effects of beta-adrenergic blockade in coronary artery disease at rest and during upright exercise. T2 - comparison of acebutolol and propranolol. AU - Kaku, R.. AU - Lee, G.. AU - Amsterdam, Ezra A. PY - 1978. Y1 - 1978. UR - http://www.scopus.com/inward/record.url?scp=0017812111&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017812111&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017812111. VL - 26. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 2. ER - ...
The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography. Fasting vaspin concentrations were compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. We did not find significant difference in vaspin level between target group and controls. Unless the pre-test probability was taken into account, we did not find vaspin difference in the target group, when dividing patients on the basis of
Chaikriangkrai, K.; Palamaner Subash Shantha, G.; Jhun, H.Yeon.; Ungprasert, P.; Sigurdsson, G.; Nabi, F.; Mahmarian, J.J.; Chang, S.Min., 2016: Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
TY - JOUR. T1 - Algorithm to predict triple-vessel/left main coronary artery disease in patients without myocardial infarction. T2 - An international cross validation. AU - Detrano, Robert. AU - Jánosi, A.. AU - Steinbrunn, Walter. AU - Pfisterer, Matthias. AU - Schmid, Johann Jakob. AU - Maggie Meyer, M.. AU - Guppy, Kern H.. AU - Abi-Mansour, Pierre. PY - 1991. Y1 - 1991. N2 - Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. These data were obtained from a total of 1,074 such subjects from patient populations at four centers (Cleveland Clinic Foundation, Cleveland, Ohio; Hungarian Institute of Cardiology, Budapest, Hungary; the university hospitals, Zurich and Basel, Switzerland; and the Veterans Administration Medical Center, Long Beach, Calif.) and used to derive four separate ...
Treatment options for patients with left main coronary artery disease.. Rev Cardiovasc Med. 2011;12(2):e77-83. Authors: Lee MS, Nguyen J. Coronary artery bypass grafting (CABG) is the gold standard for the treatment of left main disease, whereas percutaneous coronary intervention is a viable option for patients who are candidates for revascularization but ineligible for CABG. CABG is limited by extended hospital stay followed by rehabilitation and mediocre long-term patency of saphenous vein grafts. Drug-eluting stents decrease the restenosis rates compared with bare metal stents and provide comparable clinical outcomes with those of CABG. Patients with isolated left main disease limited to the ostium or midbody are most likely to have good clinical outcomes with low restenosis and stent thrombosis rates. The results of the ongoing EXCEL trial, which compares left main percutaneous coronary intervention with drug-eluting stents and CABG, will provide insight regarding the ideal revascularization ...
Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
TY - JOUR. T1 - ACR appropriateness criteria chronic chest pain - Low to intermediate probability of coronary artery disease. AU - Woodard, Pamela K.. AU - White, Richard D.. AU - Abbara, Suhny. AU - Araoz, Philip A.. AU - Cury, Ricardo C.. AU - Dorbala, Sharmila. AU - Earls, James P.. AU - Hoffmann, Udo. AU - Hsu, Joe Y.. AU - Jacobs, Jill E.. AU - Javidan-Nejad, Cylen. AU - Krishnamurthy, Rajesh. AU - Mammen, Leena. AU - Martin, Edward T.. AU - Ryan, Thomas. AU - Shah, Amar B.. AU - Steiner, Robert M.. AU - Vogel-Claussen, Jens. AU - White, Charles S.. PY - 2013. Y1 - 2013. N2 - Chronic chest pain can arise from a variety of etiologies. However, of those potential causes, the most life-threatening include cardiac disease. Chronic cardiac chest pain may be caused either by ischemia or atherosclerotic coronary artery disease or by other cardiac-related etiologies, such as pericardial disease. To consider in patients, especially those who are at low risk for coronary artery disease, are ...
The global Coronary Artery Disease Therapeutics Market report offers precise analytical information about the Coronary Artery Disease Therapeutics market. The market experts and proficient analysts generate the information based on the past and current situation of Coronary Artery Disease Therapeutics market, various factors affecting the growth trajectory, global sales, demand, total revenue generated, and capitalization of the market. Moreover, the report delivers a summarized assessment of the impact of federal policies and regulations on market operations. It also comprises detailed information pertaining to the Coronary Artery Disease Therapeutics markets current dynamics. The global Coronary Artery Disease Therapeutics market acts as a huge platform that offers several opportunities for many reputed firms, organizations, manufacturers, vendors, and suppliers AstraZeneca, Gilead, Novartis, Pfizer, Bayer, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Mylan, Teva Pharmaceutical Industries ...
Title: Surgical or Interventional Revascularization in Diabetic Patients with Coronary Artery Disease?. VOLUME: 6 ISSUE: 6. Author(s):E. Apostolakis, I. Koniari, D. Velissaris and Efstratios N. Koletsis. Affiliation:Department of Cardiothoracic Surgery, Department of Anaesthesiology and ICU, University of Patras, Patras, Greece.. Keywords:Coronary artery disease, Diabetes mellitus, Coronary artery bypass grafting, Percutaneous transluminal coronary angioplasty, Myocardial infarction, Revascularization, percutaneous transluminal, Surgical revascularization, prothrombotic situation, lipoproteins, manifestations, triglyceride-rich, triggering mechanisms, Plaque-angiogenesis, catabolism, CABG surgery, Abciximab, ischemia, SPECT, AWESOME, worsening symptoms, BASKET-LATE, MACE, perioperatively. Abstract: The combination of diabetes mellitus and coronary artery disease (CAD) constitutes an aggressive disease characterized biologically by chronic inflammatory, proliferative and pro-thrombotic situation. ...
This stock medical exhibit depicts coronary artery disease. The first image shows the normal anatomy of the heart and coronary arteries. The remaining images show cross-sectional views of the arteries. The first has a normal, open lumen. The remaining three have various degrees of stenosis/thrombosis.
OBJECTIVE: Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common null allele of LPA with lipoprotein(a) levels and CAD risk in a large case-control cohort. We have also examined how null allele genotyping complements apolipoprotein(a) isoform typing to refine the relationship between LPA isoform size and circulating lipoprotein(a) levels. APPROACH AND RESULTS: The LPA null allele (rs41272114) was genotyped in the PROCARDIS (Precocious Coronary Artery Disease) case-control cohort (4073 CAD cases and 4225 controls). Lipoprotein(a) levels were measured in 909 CAD cases and 922 controls; apolipoprotein(a) isoform size was estimated using sodium dodecyl sulfate-agarose gel electrophoresis and a high-throughput quantitative polymerase chain reaction-based method. Null carriers are
Abstract:. Background: Type 2 diabetes mellitus is often associated with severe Coronary artery disease (CAD). Since patients with higher risk of severe disease are likely to get better benefit from aggressive management, it is essential to identify factors which are associated with severe macrovascular disease. We looked at the possibility of hyperinsulinemia being a marker for severe and complex coronary artery disease in type 2 diabetes mellitus, to select patients who would benefit from aggressive treatment. Methods: A cross sectional study of 290 type 2 diabetic patients, who underwent coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited. Biochemical and anthropometric parameters were analysed. Insulin resistance was measured by homeostasis model assessment method. Angiographically measured syntax score of more than 22 is considered to be severe and complex CAD. Receiver operating curve characteristic was performed to find out the ...
Abstract:. Background: Non-communicable diseases constitute about 68% of global death annually. Among NCD deaths, cardiovascular diseases (CVD) ranks first with a share of 46.2% amounting to 17.5 million deaths. First degree relatives of patients with coronary heart disease have a higher risk of getting cardiovascular events due to interplay between genetic as well as environmental factors. The aim of this research WAS to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among first degree relatives of CAD patients. Methodology: A cross-sectional study was performed in first degree relatives of coronary artery disease patients in cardiology ward of JIPMER a tertiary care hospital in Puducherry. Overall 218 first degree relatives aged ≥18 were involved in study. The desired information was obtained using a pre-tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. WHO/ISH ...
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Background. Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups.. Methods. In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved. The Gensini score (an indicator of CAD severity) was calculated for all, and the risk factors and severity of CAD were compared between the ethnical groups, using adjusted standardized residuals, Kruskal-Wallis test, and multivariable regression analysis.. Results. The mean age of the participants (14,131 [70.1%] men and 6034 [29.9%] women) was 60.7 ± 10.8 years. The Fars (8.7%) and Gilak (8.6%) ethnic groups had the highest prevalence of ≥4 simultaneous risk factors. The mean Gensini score was the ...
Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from atherosclerosis, a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in blood flow to the heart muscle.. When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. A heart attack can permanently damage heart muscle and cause the affected area of the heart not to pump properly.. Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in the chest). Less common symptoms include nausea, sweating, fatigue, dizziness and decreased exercise tolerance.. In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. These procedures include:. ...
Ling Jun Chen, Mercer University College of Pharmacy Coronary artery disease leads to the narrowing of coronary arteries and is associated with risk factors that include cigarette smoking, hypertension, hyperlipidemia, and diabetes. [1] European and U.S. guidelines have declared that patients with coronary artery disease have an increased risk of developing ischemia and infarction. Coronary-artery…
Polymorphisms in paraoxonase 1 (PON1) coding for PON1 enzyme have been studied as genetic markers of coronary artery disease (CAD). PON1 Q192R and PON1 L55M polymorphisms have been analyzed extensively, but data on association and role of these polymorphisms in the etiology of CAD are conflicting. In this study, we tested the genetic association between PON1 Q192R and PON1 L55M polymorphisms and CAD among north Indians. MATERIALS AND METHODS: Two hundred eighty-five angiographically proven patients with coronary artery disease and 200 sex-matched and ethnically matched controls were genotyped for 2 PON1 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genotype/ allele frequencies were compared in patients and controls using the chi-square test. RESULTS: At PON1-192 locus, there were significant differences between patients and controls (P, 0.05), leading to significant odds ratios for RR genotype (OR= 1.92, CI: 1.19-3.10) and *R allele ...
Motlagh B, ODonnell M, Yusuf S. Prevalence of cardiovascular risk factors in the Middle East: a systematic review. Eur J Cardiovasc Prev Rehabilm2009;16(3):268-80. Cole JH, Sperling LS. Premature coronary artery disease:clinical risk factors and prognosis. Curr Atheroscler Rep2004;6(2):121-5. Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalized anxiety disorder: a 10-year follow-up. Br J Psychiatry 2012;200(4):324-9. Martens EJ, de Jonge P, Na B, et al. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010;67(7):750-8. Huffman JC, Smith FA, Blais MA, et al. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res 2008;65(6):557-63. Kawachi I, Sparrow D, Vokonas PS, et al. Symptoms of anxiety and risk of coronary heart disease. The NormativeAging Study. Circulation ...
TY - JOUR. T1 - Usefulness of myocardial perfusion echocardiography to identify obstructive coronary artery disease in patients with abnormal ventricular septal motion. AU - Spevack, Daniel M.. AU - Shoyeb, Abu. AU - Yoon, Andrew J.. AU - Gordon, Garet M.. AU - Matros, Todd. AU - Reynolds, Harmony A.. AU - Shah, Alan. AU - Tunick, Paul A.. AU - Kronzon, Itzhak. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Twenty-three patients who had septal wall motion abnormalities and who underwent angiography within 2 weeks were evaluated by myocardial perfusion echocardiography. Mean perfusion score (plateau video intensity times the wash-in rate) was lower in segments that were supplied by obstructed coronary arteries in real time (7.5 vs 22.6 dB/s, p ,0.005) and with end-systolic triggering (8.6 vs 20.9 dB/s, p ,0.001). Lower mean septal perfusion scores (,12 dB/s) were seen in 14 of 16 patients who had obstructive septal coronary artery disease, and normal mean septal perfusion scores were seen in 6 of 7 patients ...
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
To evaluate the effectiveness of the graded exercise test in predicting the extent of coronary artery disease and the degree of left ventricular dysfunction in patients with prior myocardial infarction, 100 consecutive patients underwent both graded exercise testing and coronary and left ventricular angiography at a median of 4 months after infarction. The studies caused no complications. An equal number of patients had anterior and inferior infarction. Coronary artery disease, defined as 70 percent or greater stenosis of luminal diameter, was present in three vessels in 31 patients, in two vessels in 35 patients, in one vessel in 33 patients and in no vessel in one patient. With diagnostic electrocardiographic criteria of 1 mm or greater J point depression plus a flat or downsloping S-T segment, 31 patients had an electrocardiographically positive exercise test; 27 of these (87 percent) had two or three vessel coronary artery disease. Of the 21 patients with a negative exercise test, 62 ...
Coronary calcium score is an independent predictor of risk of significant coronary artery disease. It may refine overall risk of coronary artery disease estimated with conventional risk factors. It is based on CT examination and calculation of the Agatston score from the images.
Medical Management Of Stable Coronary Artery Disease ,Stable Coronary Artery Disease (Management patients with stable known or suspected
In this 2-center study of 2,583 consecutive patients without prior known CAD and without obstructive CAD, nonobstructive coronary artery plaque presence and extent as identified by 64-detector row CCTA are associated with heightened mortality risk in a 3-year follow-up period. The CCTA nonobstructive plaque assessment added significant risk prediction beyond patient demographic data, traditional CAD risk factors, and Framingham risk score.. The results of the present study suggest a potential utility for diagnosis of nonobstructive CAD by CCTA. Such patients experience heightened mortality risk, even though they represent a patient population for whom functional stress testing would be expected to be negative and who might not be referred for evaluation by invasive coronary angiography (ICA) after CCTA. Our results confirm prior observations of a high negative predictive value of a normal CCTA for later adverse clinical events but are additive to the prior published reports by identifying a ...
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and
TY - CONF AU - Kotur-Stevuljević, Jelena AU - Vemić, Sava AU - Spasojević-Kalimanovska, Vesna AU - Spasić, S. AU - Jelić-Ivanović, Zorana PY - 2009 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1277 PB - Taylor & Francis Ltd, Abingdon C3 - Free Radical Research T1 - Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients VL - 43 SP - 96 EP - 97 ER ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Change in R wave amplitude (mean delta R) was measured sequentially during and after 12 lead maximal treadmill exercise tests in 14 subjects with normal coronary arteries and 62 patients with coronary artery disease. In normal subjects mean delta R decreased maximally one minute after exercise and returned to control levels within three minutes. In contrast, mean delta R increased in patients with coronary artery disease, the greatest change occurring in patients with either triple vessel or left main disease or those with an akinetic region on the left ventriculogram. R wave amplitude returned to resting levels in five minutes. Increase in R wave amplitude was not directly related to changes in the ST segment. Changes in R wave amplitude during maximal treadmill exercise may improve the discrimination between patients with and without coronary artery disease and may help to identify those patients with abnormal left ventricular function. ...
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries. This paper reports on patients with coronary artery disease. Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous coronary intervention, or previous multi-vessel coronary artery bypass graft surgery. After a 30-day run ...
The purpose of this study is to determine whether the safety and efficacy of coronary stent implantation using Everolimus-Eluting Coronary Stent System (Abbott, Boston Scientific) is not inferior to coronary artery bypass grafting (CABG) for the treatment of patient with multivessel coronary artery disease (CAD ...
Coronary artery disease may be the leading global reason behind mortality. the best global reason behind mortality.2 A lot more than 900,000 individuals in america are affected a myocardial infarction (coronary attack) or die of CAD this season.3 Package 1 , The pathophysiology and 38390-45-3 manufacture treatment of coronary artery disease Coronary artery disease (CAD) identifies the build-up of atherosclerotic plaque in the arteries that supply air and nutrients towards the center (examined in REF 127). The complicated procedure for atherosclerosis starts early in existence and is considered to initiate with dysfunction of endothelial cells that collection the coronary arteries; these cells are no more able to properly regulate vascular firmness (narrowing or constriction from the vessels) with nitric oxide signalling. Intensifying infiltration from the vessel wall structure by lipoprotein contaminants transporting cholesterol propagates an inflammatory response by cholesterol-loaded ...
Coronary artery disease[edit]. The primary health risk identified for trans fat consumption is an elevated risk of coronary ... the main artery of the heart, thereby raising risk of coronary artery disease.[63] ... Although trans fats are edible, consuming trans fats has been shown to increase the risk of coronary artery disease in part by ... This is because any incremental increase in trans fat intake increases the risk of coronary artery disease.[55] ...
Coronary Artery Disease. 23 (6): 368-374. doi:10.1097/MCA.0b013e3283564930. PMID 22735090. Oliveira, André G.; Marques, Pedro E ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the pertioneal fluid. It binds ... Istradefylline - Antagonist of the adenosine A2A receptor, used in the treatment of Parkinson's disease as an adjunct to L-DOPA ...
Severe coronary artery disease. *Aggressive breast, uterine or ovarian cancer. Relative contraindications[edit]. *Migraine ... Coronary heart disease events. ( non-fatal myocardial infarction. , death. ). 1.29 (1.02-1.63). 1.32 (1.02-1.72). 1.18 (0.70- ... The WHI reported statistically significant increases in rates of breast cancer, coronary heart disease, strokes and pulmonary ... A subset of the events was combined in a "global index", defined as the earliest occurrence of coronary heart disease events, ...
Coronary Artery Disease. 17 (7): 611-21. doi:10.1097/01.mca.0000224420.67304.4d. PMID 17047445. S2CID 1884596. Soni D, Wang DM ... is often seen in patients with coronary artery disease, diabetes mellitus, hypertension, hypercholesterolemia, as well as in ... Mäyränpää MI, Heikkilä HM, Lindstedt KA, Walls AF, Kovanen PT (November 2006). "Desquamation of human coronary artery ... is a hallmark for vascular diseases, and is often regarded as a key early event in the development of atherosclerosis.[citation ...
Gundu HR Rao, S Thanikachalam (2005). Coronary Artery Disease. Jaypee Publications. p. 324. ISBN 9788180614507. Retrieved 28 ...
A 2014 meta-analysis concluded that cardiovascular disease, such as coronary artery disease and stroke, is less likely with ... Coronary Artery Disease. 27 (7): 566-72. doi:10.1097/MCA.0000000000000397. PMID 27315099. S2CID 7980392. D'Elia, Lanfranco; La ... Moderate coffee consumption is not a risk factor for coronary heart disease. A 2012 meta-analysis concluded that people who ... "Coffee consumption and risk of coronary heart diseases: A meta-analysis of 21 prospective cohort studies". International ...
Coronary artery disease is the leading cause of death in the US general population. Hypercholesterolemia or high cholesterol is ... McCullough, P. A. (11 April 2007). "Coronary Artery Disease". Clinical Journal of the American Society of Nephrology. 2 (3): ... considered a major risk factor in coronary artery disease. Therefore, major efforts are focused toward understanding regulation ...
Bell, David S.H. (October 1996). "Diabetes mellitus and coronary artery disease". Coronary Artery Disease. 7 (10): 715-722. doi ... There is also a correlation between those with diseases such as chronic kidney disease, coronary artery disease, or diabetes ... Statins are a class of drugs used to treat cardiovascular disease by lowering lipid levels. Statins have shown to reduce new ... high-density lipoproteins and cardiovascular disease". European Heart Journal. 38 (20): 1597-1607. doi:10.1093/eurheartj/ehx118 ...
"Left anterior descending artery length in left and right coronary artery dominance". Coronary Artery Disease. 12 (1): 77-78. ...
Atherosclerosis is the leading cause of coronary artery disease. And, ischaemic heart disease is the leading cause of mortality ... "Coronary Artery Disease (CAD)". cdc.gov. Retrieved 18 January 2021. "The top 10 causes of death". who.int. Retrieved 2 January ... "DIETARY FATS AND CORONARY HEART DISEASE: UNFINISHED BUSINESS". thelancet.com. Retrieved 18 January 2021. Frantz Jr, I. D.; ... low cholesterol diet in secondary prevention of coronary heart disease. link.springer.com. Advances in Experimental Medicine ...
High levels of homocysteine are linked to cardiovascular disease and atherosclerosis, particularly coronary artery disease. ... "Homocysteine and coronary artery disease". In Carmel, Ralph; Jacobsen, Ralph Carmel (eds.). Homocysteine in Health and Disease ... Refsum H, Ueland PM, Nygård O, Vollset SE (1998). "Homocysteine and cardiovascular disease". Annual Review of Medicine. 49: 31- ... has been linked to non-alcoholic fatty liver disease. This substitution has also been linked to increased frequency of non- ...
Valentin Fuster, Eric J. Topol, Elizabeth G. Nabel (2005). "Atherothrombosis and Coronary Artery Disease". p. 8. Lippincott ... In his correspondence with Heberden, he wrote: "How much the heart must suffer from the coronary arteries not being able to ... Although the disease was declared eradicated, some pus samples still remain in laboratories in Centers for Disease Control and ... No disease followed. The boy was later challenged with variolous material and again showed no sign of infection. Donald Hopkins ...
... is a database of genes involved in coronary artery disease (CAD) . Coronary artery disease Liu, Hui; Liu Wei; Liao ... a comprehensive database for coronary artery disease genes". Nucleic Acids Res. England. 39 (Database issue): D991-6. doi: ...
Nwasokwa, ON (1 October 1995). "Coronary artery bypass graft disease". Annals of Internal Medicine. 123 (7): 528-45. doi: ... upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European ... "Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from ... "ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of ...
Coronary artery disease (CAD), also known as ischemic heart disease, is responsible for 62 to 70 percent of all SCDs. CAD is a ... Current cigarette smokers with coronary artery disease were found to have a two to threefold increase in the risk of sudden ... The most common cause of cardiac arrest is coronary artery disease. Less common causes include major blood loss, lack of oxygen ... The risk factors for SCD are similar to those of coronary artery disease and include age, cigarette smoking, high blood ...
Meanwhile, he is diagnosed with coronary artery disease. In his attempt to standby his principle, he wages war against the ...
Padmanaban, P.; Toora, B. (2011). "Hemoglobin: Emerging marker in stable coronary artery disease". Chronicles of Young ... A recent study done in Pondicherry, India, shows its importance in coronary artery disease.[83] ... The best known hemoglobinopathy is sickle-cell disease, which was the first human disease whose mechanism was understood at the ... Role in disease[edit]. Hemoglobin deficiency can be caused either by a decreased amount of hemoglobin molecules, as in anemia, ...
Desai, Chintan S.; Blumenthal, Roger S.; Greenland, Philip (2014). "Screening low-risk individuals for coronary artery disease ... It thus has potential for screening for coronary artery disease,[17] although no evidence-based recommendations can be made ... Detection of peripheral artery disease. The ankle-brachial pressure index (ABPI) or ankle-brachial index (ABI) is the ratio of ... lower blood pressure in the leg suggests blocked arteries due to peripheral artery disease (PAD). The ABPI is calculated by ...
Cerebrovascular or coronary artery disease (current or history). *Valvular heart disease with thrombogenic complications ...
"Diagnostic Imaging of Coronary Artery Disease". Lippincott Williams and Wilkins publishers. Some of his patents include Cardiac ... ISBN 0-471-36166-6. OCLC 47092430.CS1 maint: others (link) Aziz, Kusai S. (2009). Diagnostic imaging of coronary artery disease ... Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients with Acute Coronary and Cerebrovascular Syndromes ... "Frequency of Cholesterol Crystals in Culprit Coronary Artery Aspirate During Acute Myocardial Infarction and Their Relation to ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and ... "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and ... is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease ...
For the prevention of myocardial infarction (MI) in someone with documented or suspected coronary artery disease, much lower ... May 2007). "Aspirin resistance in patients with stable coronary artery disease with and without a history of myocardial ... January 2018). "2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with ... Hall SL, Lorenc T (February 2010). "Secondary prevention of coronary artery disease". American Family Physician. 81 (3): 289-96 ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... "Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in ... "Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial ... "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Human Molecular ...
Frank ST (August 1973). "Aural sign of coronary-artery disease". N. Engl. J. Med. 289 (6): 327-8. doi:10.1056/ ...
Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction. The process ... Wang Q (2005). "Advances in the Genetic Basis of Coronary Artery Disease". Current Atherosclerosis Reports. 7 (3): 235-41. doi: ... Wang Q (2005). "Molecular genetics of coronary artery disease". Curr. Opin. Cardiol. 20 (3): 182-8. doi:10.1097/01.hco. ...
Russ was a co-editor, with Valentín Fuster and Eric J. Topol, of the textbook Atherosclerosis and Coronary Artery Disease. He ... 2005). Atherothrombosis and Coronary Artery Disease. Lippincott Williams & Wilkins. p. xxv of Preface. ISBN 9780781735834.. ... Instead of a site for passive accumulation of blood lipids, the artery wall is now seen as a living, reactive tissue capable of ... Chronic endothelial injury hypothesis Nagourney, Eric (22 March 1999). "Russell Ross, 69, Pioneer in Artery Research". NY TImes ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... Presence of a constitutively active NF-κB pathway manifests in multiple myeloma and other cancer-related diseases. Removal of ... Digestive Diseases. 30 (5): 453-68. doi:10.1159/000341690. PMID 23108301. S2CID 13165828. Fernandes MT, Dejardin E, dos Santos ... but prolonged inflammation can cause serious cellular damage and increase the risk of certain diseases including cancer. Thus, ...
... severe heart failure or coronary artery disease. Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, ... Given the importance of insulin resistance as a risk factor for cardiovascular disease, it is of considerable relevance that it ... such as kidney disease and cardiac hypertrophy. Effects on insulin resistance In all animal models of insulin resistance, ... Parkinson's disease, glaucoma. Use in pregnancy is discouraged. Moxonidine passes into breast milk. Excess mortality has been ...
Age, Serum Cholesterol and Coronary Artery Disease. 1950. August 23, 2006. . Garn, Stanley. Human Races. Charles Thomas. ... beginning with human hair and eventually contributing research on determinants of coronary artery disease, somatotype, human ... ages of thirty and fifty have their serum cholesterol rise which contributes to an increase risk for coronary artery disease. ... Garn died of complications from peripheral vascular disease on August 31, 2007, in Ann Arbor Michigan. [1] Garn remains a ...
2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ... Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease». Gastroenterology. 139 (1): ...
2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161 ... "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 ... haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular medicine (Cambridge, ...
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review ... and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants.. ... A.M.A. Recognizes Obesity as a Disease. New York Times. 2013-06-18 [2015-11-19]. (原始内容存档于2013-06-23).. ... Centers for Disease Control and Prevention. 2007-05-22 [2007-09-05]. (原始内容存档于2007-10-09
"Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population". Int ... Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Other uncommon causes are Trousseau disease,[medical citation needed] Beurger's disease (Thromboangiitis obliterans),[medical ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ...
... which is the principal cause of coronary heart disease and other forms of cardiovascular disease. In contrast, HDL particles ( ... particles are strongly associated with the presence of atheromatous disease within the arteries. For this reason, LDL is ... "Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention ... This disease process leads to myocardial infarction (heart attack), stroke and peripheral vascular disease. Since higher blood ...
They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to ... Role in disease[edit]. Few congenital disorders of the fibrinolytic system have been documented. Nevertheless, excess levels of ... Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ... The fibrinolytic system is closely linked to control of inflammation, and plays a role in disease states associated with ...
... and coronary arteries.[8] to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 ... in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease.[citation needed] ... Hughes AD, Sever PS (1989). "Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries". ...
Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries ... treatment or prevention of disease": 21 U.S.C. § 321(g)(1)(B).[23] However the legal position is not entirely straightforward,[ ...
The most common problem in FH is the development of coronary artery disease (atherosclerosis of the coronary arteries that ... reduction in death from coronary heart disease to a point where people are no more likely to die of coronary heart disease than ... Peripheral artery occlusive disease (obstruction of the arteries of the legs) occurs mainly in people with FH who smoke; this ... Cardiovascular diseaseEdit. Accelerated deposition of cholesterol in the walls of arteries leads to atherosclerosis, the ...
Indians are at particularly high risk for atherosclerosis and coronary artery disease. This may be attributed to a genetic ... Diarrheal diseases are the primary causes of early childhood mortality. These diseases can be attributed to poor sanitation and ... Diseases such as dengue fever, hepatitis, tuberculosis, malaria and pneumonia continue to plague India due to increased ... The provision of clean drinking water and sanitation as one of the principal factors in control of diseases is well established ...
This 'Grow Your Own Arteries' technique is helping patients survive coronary heart disease, renal failure and other life- ... This process is undergoing pre-clinical trials in humans and may be used to treat patients suffering coronary heart disease, ... These tissue-engineered 'artificial arteries' have potential use as access fistulae for haemodialysis patients and as coronary ... in heart diseases). She further determined how these cells could be maintained in the 'non-disease' phenotype. This knowledge ...
Coronary artery aneurysm. *head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... "Epidemiology of Hypertensive Kidney Disease".. CS1 maint: uses authors parameter (link). *^ Rowe, D J; Bagga, H; Betts, P B ( ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ...
... assess the effects of a guided imagery audiotape intervention on psychological outcomes in patients undergoing coronary artery ... which in turn has a significant influence on the immune system and its capacity to defend the body against disease infection, ...
"Coronary Artery Disease (CAD)"। ১২ মার্চ ২০১৩। ২ মার্চ ২০১৫ তারিখে মূল থেকে আর্কাইভ করা। সংগ্রহের তারিখ ২৩ ফেব্রুয়ারি ২০১৫।. ... Coronary artery disease. অন্যান্য নাম. মেদের কঠিনীভবনজাত হৃদ্‌রোগ,[১] মেদের কঠিনীভবনজনিত রক্তসংবহন রোগ,[২] পরিবেষ্টক হৃদ্‌রোগ[৩ ... হৃৎ-ধমনীর ব্যাধি (ইংরেজি: Coronary artery disease)[১৩] হৃৎ-সংবহন ব্যাধিগুলির মধ্যে সবচেয়ে বেশি সাধারণ।[১৪] হৃৎ-ধমনীর ... Centers for Disease Control and Prevention, (CDC) (১৪ অক্টোবর ২০১১)। "Prevalence of coronary heart disease-United States, 2006- ...
... valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. When Dupuytren's disease is at the ... Cardiovascular disease. Radiation can increase the risk of heart disease and death as observed in previous breast cancer RT ... Cardiovascular late side effects have been termed radiation-induced heart disease (RIHD) and radiation-induced vascular disease ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
2007). "Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial". ... Alzheimer's disease[edit]. There is no evidence that donepezil or other similar agents alters the course or progression of ... coronary artery bypass surgery cognitive impairment,[32] cognitive impairment associated with multiple sclerosis, CADASIL ... Donepezil, sold as the trade name Aricept among others, is a medication used to treat Alzheimer's disease.[4] It appears to ...
Forrester JS, Litvack F, Grundfest W, Hickey A (1987). "A perspective of coronary disease seen through the arteries of living ... Coronary artery angioscopy, which first was used to reveal the presence of a blood clot in the coronary arteries of patients ... In this technique, a flexible fiberoptic catheter inserted directly into an artery.[1] It can be helpful in diagnosing e.g. ...
The most common cause of sudden death in the US is coronary artery disease. Approximately 300,000 people die suddenly of this ... Also, there are many inherited conditions and heart diseases that can affect young people that can cause sudden death. Many of ... Alpha-linolenic acid, cardiovascular disease and sudden death. pubmed. 2007-01-18 कथं। ...
... in the association of coronary calcified plaque in that there is less calcified atherosclerotic plaque in the coronary arteries ... Cardiovascular disease[edit]. Evidence suggests that dietary vitamin D may be carried by lipoprotein particles into cells of ... The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification.[23] Moreover, the ... "Active serum vitamin D levels are inversely correlated with coronary calcification". Circulation. 96 (6): 1755-60. doi:10.1161/ ...
2006). "Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic ... "Center for disease control and prevention. Pridobljeno dne 6. april 2009.. *↑ 17,0 17,1 Flegal KM, Ogden CL, Wei R, Kuczmarski ... "Centers for Disease Control and Prevention. Pridobljeno dne 2008-07-09.. *↑ Marantz PR; Bird ED; Alderman MH (marec 2008). "A ... Mazzone, Theodore; Fantuzzi, Giamila (2006). Adipose Tissue And Adipokines in Health And Disease (Nutrition and Health). Totowa ...
L-type calcium channel blockers can induce dilation of the coronary arteries while also decreasing the heart's demand for ... Beta-receptor antagonists should be avoided in patients with reactive pulmonary disease to avoid asthma attacks. Also Beta- ... Regarding coronary vasospasm, one surgical intervention, referred to as percutaneous coronary intervention or angioplasty, ... in the blood and inducing coronary vasodilation which will allow for more coronary blood flow due to a decreased coronary ...
a b Douglas, H., Moore, M., & Purvis, J. (2012). Comprehensive assessment of a quadricuspid aortic valve and coronary arteries ... The Journal of Heart Valve Disease, 13(4), 534-537. *^ a b c Zhu, J., Zhang, J., Wu, S., Zhang, Y., Ding, F., & Mei, J. (2013 ... and abnormal displacement of the ostium in the right coronary artery in association with QAV.[4][6] Some research has shown ... Multidetector coronary CT angiography has been indicated as a single competent diagnostic imaging tool capable of delineating ...
Chronic severe hepatic disease. *HIV infection in association with a last known CD4 count of ,50/mm3 ... Coronary care unit (CCU). *Critical illness insurance. Conditions. Organ system failure. Shock sequence. SIRS. Sepsis. Severe ...
The symptoms of the disease will depend on the affected valve, the type of disease, and the severity of the disease. For ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... These two arteries receive blood from the ventricles and their semilunar valves permit blood to be forced into the arteries, ... Main article: Valvular heart disease. Valvular heart disease is a general term referring to dysfunction of the valves, and is ...
Deaths from coronary artery disease‎ (18 P). *. ► Deaths from myocardial infarction‎ (1,274 P) ... Pages in category "Heart disease". The following 14 pages are in this category, out of 14 total. ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Category:Heart_disease&oldid=4463909" ...
... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ... leading to pathologic changes in the small arteries of the kidney. Affected arteries develop endothelial dysfunction and ... Coronary perfusion pressures are decreased by these factors, which also increase myocardial oxygen consumption, possibly ... The risks of developing a life-threatening disease affecting the heart or brain increase as the blood flow increases. Commonly ...
"Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: ... The American Review of Respiratory Disease. 141 (2): 352-56. doi:10.1164/ajrccm/141.2.352. PMID 2154152.. ... but calcium supplements are associated with a higher risk of coronary artery calcification.[8] ... which can increase the risk of heart disease, and cause other serious health problems.[7] ...
心臟內科加護病房(英语:Coronary care unit)(CCU) ... 單核球和顆粒球(英语:Template:Monocyte and granulocyte disease) ... 肺動脈導管(英语:Pulmonary artery catheter). *血
Coronary artery disease. Synonyms. Atherosclerotic heart disease,[1] atherosclerotic vascular disease,[2] coronary heart ... Typically, coronary artery disease occurs when part of the smooth, elastic lining inside a coronary artery (the arteries that ... have pain due to coronary artery disease.[24] Risk factors[edit]. Coronary artery disease has a number of well determined risk ... Coronary artery disease (CAD), also known as ischemic heart disease (IHD),[13] refers to a group of diseases which includes ...
Learn what causes coronary artery disease (CAD) and how it is diagnosed. Get the facts from the CDC. ... What is coronary artery disease?. Coronary artery disease (CAD) is the most common type of heart disease in the United States. ... Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary ... Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary ...
It is caused by atherosclerosis, an accumulation of fatty materials on the inner linings of arteries. ... Coronary Artery Disease Definition Coronary artery disease is a narrowing or blockage of the arteries and vessels that provide ... Coronary Artery Disease. Definition. Coronary artery disease is a narrowing or blockage of the arteries and vessels that ... Coronary Artery Disease. Definition. Coronary artery disease is a stenosis (narrowing) or blockage of the arteries and vessels ...
Coronary artery disease is a widespread problem and claims millions of lives worldwide every year. The condition has severe ... Coronary artery bypass grafting (CABG). Medical management of coronary artery disease. Various drugs are available that can ... www.escardio.org/.../...Stable_Coronary_Artery_Disease_web_addenda.pdf. *www.nhs.uk/Conditions/Coronary-heart-disease/Pages/ ... Coronary Artery Disease Treatment. News-Medical. 30 July 2021. ,https://www.news-medical.net/health/Coronary-Artery-Disease- ...
Coronary artery disease describes a condition where the coronary arteries that supply the heart with oxygen and nutrients ... Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are ... Coronary artery disease describes a condition where the coronary arteries that supply the heart with oxygen and nutrients ... www.escardio.org/.../...Stable_Coronary_Artery_Disease_web_addenda.pdf. *www.nhs.uk/Conditions/Coronary-heart-disease/Pages/ ...
Coronary artery disease affects the arteries that supply the heart muscle with blood. Although it can be life-threatening, it ... Coronary artery disease (CAD) happens so often you probably know someone who has it. Its the most common type of heart disease ... Coronary artery disease (CAD) becomes more likely as you get older or if it runs in your family. But you can manage many other ... Coronary artery bypass grafting is a type of surgery in which doctors use blood vessels from other parts of your body to make a ...
... or coronary heart disease, can lead to heart attack or death. Learn what causes this condition and how you can prevent it. ... What is coronary artery disease?. Coronary artery disease (CAD), also called coronary heart disease, is the most common type of ... What causes coronary artery disease?. Atherosclerosis, which involves the clogging and hardening of arteries, is the number one ... artery vasculitis (the inflammation of an artery). *a spontaneous coronary artery dissection (when there is a tear through the ...
Coronary heart disease (CHD)-also sometimes called coronary artery disease-is the most common form of cardiovascular disease, a ... Coronary heart disease (CHD)-also sometimes called coronary artery disease-is the most common form of cardiovascular disease, a ... A mammary artery or a vein taken from the leg is grafted onto the damaged coronary artery to circumvent a narrowed or blocked ... A coronary angiography is performed to determine the presence of narrowing of the coronary arteries. In this procedure a tiny ...
... Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from ... minimally invasive coronary artery bypass surgery. *Hybrid minimally invasive coronary artery bypass and coronary artery stent ... Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in ... a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in ...
Pulse pressure correlates with coronary artery calcification and risk for coronary heart disease: a study of elderly ... Additional roles of diastolic parameters in the diagnosis of obstructive coronary artery disease. Kim, Hyue Mee; Kim, Hack- ... The association between uric acid levels and different clinical manifestations of coronary artery disease ... Giant unruptured circumflex coronary artery aneurysms presenting as acute coronary syndrome. Sucato, Vincenzo; Manno, Girolamo ...
Coronary artery disease and rheumatoid arthritis.. Goodson N1.. Author information. 1. Arthritis Research Campaign, ... It is not clear why rheumatoid patients have higher rates of coronary disease. Traditional cardiovascular risk factors do not ... It may be that these new cardiovascular risk factors are responsible for accelerating coronary heart disease in patients with ... This article reviews recent literature relating to the epidemiology of cardiovascular disease in the context of RA. ...
Extracellular vesicles in coronary artery disease.. Boulanger CM1,2, Loyer X1,2, Rautou PE1,3,4, Amabile N1,5. ... This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging ... valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease. ...
Here are the left and right coronary arteries. ... Here are the left and right coronary arteries. They supply ... Eventually, the artery may become too narrow for clotted blood to pass through. If it does, the artery could become completely ... In a healthy artery, red blood cells flow through unimpeded. But if the inner wall is damaged, cholesterol plaque can build up ... That would cause a lack of oxygen, or ischemia, in the part of the heart the artery supplies. The result is a heart attack, ...
Its known as hardening of the arteries, too. Arteries carry blood and oxygen to your heart. ... Coronary Heart Disease is plaque buildup in your arteries. ... Coronary Artery Disease (CAD). Coronary artery disease is also ... Coronary heart disease (CHD) is the most common type of heart disease. It is also called coronary artery disease (CAD). CHD is ... What causes coronary heart disease?. Coronary heart disease develops over time. It occurs as your arteries become blocked from ...
Get inspiration for Coronary Artery Disease Powerpoint Template. Browse through our huge selection of community templates or ... Coronary Artery Disease. Transcript: Coronary Artery Disease Narrowing of the blood vessels Causes Atherosclerosis- arteries ... Heart Disease Scientific Name - Coronary Artery Disease Other Names - Ischemic Heart Disease Prevention Coronary Heart Disease ... Coronary Artery Disease Powerpoint Template. Coronary Artery Disease Powerpoint Template. Create your presentation by reusing a ...
Prognosis of severe coronary artery disease with no indication of percutaneous coronary intervention or coronary artery bypass ... Evaluation of the predictive value of coronary artery calcium score for obstructive coronary artery disease in asymptomatic ... Coronary artery disease in patients with dementia. Fowkes, Ross; Byrne, Matthew; Sinclair, Hannah; More ... Serum YKL-40 levels in patients with coronary artery disease. Kucur, Mine; Isman, Ferruh K.; Karadag, Bilgehan; More ...
Coronary artery disease (CAD) occurs when these arteries become blocked. CAD, which typically builds up over decades, is the ... most common form of heart disease and is the leading cause of heart disease-related death worldwide. ... Your coronary arteries are the large blood vessels that supply your heart muscle with oxygen-rich blood. ... Coronary Artery Disease Treatment at BIDMC. In some cases, coronary artery disease can be managed with lifestyle changes aimed ...
Prevalence of Subclinical Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography in 45- to 55-Year-Old ... of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients With Stable Coronary Artery Disease Ankur ... of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Patients With Stable Coronary Artery DiseaseThree-Year ... Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest ...
Coronary Artery Disease Clinical Research Trial Listings in Cardiology/Vascular Diseases Family Medicine Genetic Disease on ... Seeking Oklahomans with Diabetes who also have Coronary Artery Disease. Coronary artery disease (CAD) is the disease of blood ... Coronary Artery Disease Clinical Trials. A listing of Coronary Artery Disease medical research trials actively recruiting ... TAKEDA EXAMINE trial patients for who have Type II diabetes & ACS coronary artery disease, post angiogram or heart attack. This ...
Learn the definition of coronary artery disease, as well as t he many screening procedures commonly used to diagnose the ... disease, including EKG, exercise cardiac stress test, radionuclide stress test, stress echocardiography, CT scanning, and ... Coronary heart disease or coronary artery disease (CAD) is atherosclerosis (plaque in artery walls) of the inner lining of the ... Coronary heart disease begins when hard cholesterol substances (plaques) are deposited within a coronary artery. The coronary ...
Coronary Artery Disease Clinical Research Trial Listings in Cardiology/Vascular Diseases Family Medicine Genetic Disease on ... Coronary Artery Disease Clinical Trials. A listing of Coronary Artery Disease medical research trials actively recruiting ... Statin Recapture Therapy Before Coronary Artery Bypass Grafting Patients with coronary artery disease (CAD) requiring coronary ... Impact of Chronic Kidney Disease on the Effects of Ticagrelor in Patients With Diabetes and Coronary Artery Disease ...
Coronary Artery Disease (Atherosclerosis) - Ottawa Heart Institute www.ottawaheart.ca/heart-condition/coronary-artery-disease- ... The aim of this study was to describe coronary risk factors in a group of patients with three-vessel coronary artery disease in ... Risk factors for coronary artery disease: Historical perspectives ... www.heartviews.org/article.asp?issn=1995-705X;year=2017; ... Risk factors for three-vessel coronary artery disease in patients of ... www.elsevier.es/es-revista-archivos-cardiologia-mexico ...
Coronary artery disease (CAD) is the leading cause of death in the United States. Learn the definition, symptoms, and causes of ... Coronary artery disease (CAD) causes impaired blood flow in the arteries that supply blood to the heart. Also called coronary ... fully titled as the circumflex branch of the left coronary artery, is an artery that branches off from the left coronary artery ... The risk for coronary artery disease is also higher if you have a family history of the disease. ...
Coronary artery disease and stable angina. Definition. Coronary artery disease is a pathological condition in which a coronary ... Optimal cardiac strategy based on the history of myocardial infarction in type 2 diabetic patients with coronary artery disease ... TRIB1 and TRPS1 variants, G × G and G × E interactions on serum lipid levels, the risk of coronary heart disease and ischemic ... HIV infection and coronary heart disease: mechanisms and management Antiretroviral therapy has transformed HIV infection into a ...
Includes causes and symptoms of heart disease. Looks at cholesterol, hypertension, and risk of heart attack. Covers diet, ... Coronary Artery Disease. Topic Overview. What is coronary artery disease?. Coronary artery disease is the most common type of ... What causes coronary artery disease?. Coronary artery disease is caused by hardening of the arteries, or atherosclerosis. This ... the coronary arteries), it is called coronary artery disease.. When plaque builds up in the coronary arteries, the heart may ...
Stable Coronary Artery Disease, Cocaine-Induced Coronary Vasospasm, Vasospastic Angina, Acute Coronary Syndrome, Acute Coronary ... High Risk Acute Coronary Syndrome Management, Moderate Risk Acute Coronary Syndrome Management, Low Risk Acute Coronary ... Coronary Artery Disease is a chapter in the book, Cardiovascular Medicine, containing the following 18 pages: ... Syndrome Immediate Management, Acute Coronary Syndrome Adjunctive Therapy, ...
Stable Coronary Artery Disease, Cocaine-Induced Coronary Vasospasm, Vasospastic Angina, Acute Coronary Syndrome, Acute Coronary ... High Risk Acute Coronary Syndrome Management, Moderate Risk Acute Coronary Syndrome Management, Low Risk Acute Coronary ... Spontaneous Coronary Artery Dissection, Myocardial Ischemia in Intensive Care, ... Coronary Artery Disease is a chapter in the book, Cardiovascular Medicine, containing the following 20 pages: ...
Cardiovascular disease prevention, Brachytherapy, Coronary artery disease, Heart valve disease, Hypertrophic cardiomyop...athy ... Cardiac catheterization, Echocardiogram, Coronary angioplasty and stenting, Coronary artery disease, Heart valve diseas...e, ... Heart valve disease, Coronary artery disease, Thoracic aortic aneurysm, Lung cancer, Atrial fibrillation, Heart failure ... See a list of publications about coronary artery disease by Mayo Clinic doctors on PubMed, a service of the National Library of ...
Acute coronary syndrome, Pericardial disease, Heart valve disease, Congestive heart failure, Coronary artery disease, ... Echocardiogram, Coronary artery disease, Heart valve disease, Pericarditis, Shortness of breath, Cardiomyopathy ... See a list of publications about coronary artery disease by Mayo Clinic doctors on PubMed, a service of the National Library of ... Mayo Clinic Q and A: Coronary artery disease -- prevention and early warning signs Nov. 23, 2018, 10:00 p.m. CDT ...
Coronary artery disease is a build-up of plaque in the arteries, which restricts the flow of oxygen-rich blood and nutrients to ... Question: What is coronary artery disease?. Answer: Coronary artery disease (also called coronary heart disease) is a build-up ... Ask the doctor: Facts on coronary artery disease. Coronary artery disease is a build-up of plaque in the arteries, which ... Ask the doctor: Facts on coronary artery disease Coronary artery disease is a build-up of plaque in the arteries, which ...
  • Illustration depicting atherosclerosis in a coronary artery. (wikipedia.org)
  • It is caused by atherosclerosis, an accumulation of fatty materials on the inner linings of arteries. (encyclopedia.com)
  • Coronary artery disease is usually caused by atherosclerosis. (encyclopedia.com)
  • The formation of a plaque in the artery is called atherosclerosis and the plaque is called an atheroma. (news-medical.net)
  • That makes arteries become harder and narrower, which doctors call "atherosclerosis. (webmd.com)
  • Atherosclerosis, which involves the clogging and hardening of arteries, is the number one cause of CAD. (healthline.com)
  • Atherosclerosis is thought to happen in areas of the arteries that have turbulence, with unsteady and swirling blood flow, but other factors such as hypertension (high blood pressure), infections, and chemicals can damage the artery walls. (healthline.com)
  • Coronary heart disease is generally due to the buildup of plaques in the arterial walls, a process known as atherosclerosis. (healthcentral.com)
  • Coronary artery disease results from atherosclerosis, a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in blood flow to the heart muscle. (emoryhealthcare.org)
  • Atherosclerosis, or "hardening" of the arteries, occurs when plaque builds up inside the artery walls, causing the arteries to narrow. (bidmc.org)
  • Coronary heart disease or coronary artery disease ( CAD ) is atherosclerosis ( plaque in artery walls) of the inner lining of the blood vessels that supply blood to the heart . (rxlist.com)
  • A similar term, arteriosclerosis which means hardening or stiffening of the arteries is sometimes interchanged with atherosclerosis by some authors. (rxlist.com)
  • In CAD, the coronary arteries become narrow and stiff due to atherosclerosis and inflammation. (healthgrades.com)
  • Atherosclerosis is the buildup of plaque inside arteries. (healthgrades.com)
  • Atherosclerosis and inflammation are the main cause of coronary artery disease. (healthgrades.com)
  • In atherosclerosis, cholesterol-containing plaque builds up on the inside wall of arteries. (healthgrades.com)
  • The most common cause of CAD is vascular injury with cholesterol plaque buildup in the arteries, known as atherosclerosis . (healthline.com)
  • Coronary artery disease is a pathological condition in which a coronary artery is narrowed or blocked, usually as a result of atherosclerosis. (nature.com)
  • This Review discusses the clinical features of cardiovascular disease in patients with HIV infection, including the mechanisms underlying HIV-associated atherosclerosis and approaches to reduce the cardiovascular risk. (nature.com)
  • Coronary artery disease is caused by hardening of the arteries, or atherosclerosis . (rexhealth.com)
  • Atherosclerosis can affect any arteries in the body. (rexhealth.com)
  • Coronary Artery Disease is the proper term for this condition which is usually caused by atherosclerosis meaning clogging of the arteries by cholesterol and fatty deposits. (empowher.com)
  • It also damages arteries and promotes atherosclerosis and blood clot formation. (healthcentral.com)
  • Typically, advancing atherosclerosis leads to narrowing or occlusion of major coronary arteries and their branches, resulting in angina, heart failure, or myocardial infarction. (ahajournals.org)
  • This is often called hardening of the arteries or atherosclerosis . (heartandstroke.ca)
  • Over the years, plaque accumulates at the site of the injury in a process called atherosclerosis or hardening of the arteries. (heartandstroke.ca)
  • Anger proneness predicts coronary heart disease risk: prospective analysis from the Atherosclerosis Risk in Communities (ARIC) study. (chiroweb.com)
  • Coronary stents are typically used to prevent heart attacks in people who are diagnosed with Coronary Artery Disease caused by Atherosclerosis (hardening of the arteries or clogged arteries). (sandrarose.com)
  • A waxy substance called plaque builds up inside these arteries, leading to atherosclerosis. (reportlinker.com)
  • A build-up of fat and cholesterol in the blood that sticks to the inner walls of the arteries (this is also called atherosclerosis). (cardiosmart.org)
  • A study in the Journal of Addiction Medicine , the official journal of the American Society of Addiction Medicine (ASAM), reports that stopping or reducing cocaine use can potentially reverse the process of coronary atherosclerosis. (eurekalert.org)
  • Since 2000, the researchers have been studying the development of coronary atherosclerosis ("hardening of the arteries") in more than 700 African-American patients with cocaine use. (eurekalert.org)
  • Dr. Lai and colleagues performed a follow-up study in 15 patients with cocaine use for an average of 20 years and atherosclerosis causing more than 50 percent blockage of the coronary arteries. (eurekalert.org)
  • The reduction was significant not only for total coronary plaques, but also for noncalcified plaques--the first step in the development of coronary atherosclerosis. (eurekalert.org)
  • Autopsy studies found a strong correlation between the secretion of chemerin in peripheral tissues and aortic and coronary atherosclerosis. (ingentaconnect.com)
  • Most often, CAD develops from a buildup of plaque-fat, cholesterol, collagen, inflammatory cells and other substances-that collect in the walls of the coronary artery, which is called atherosclerosis. (cardiosmart.org)
  • In CAD, atherosclerosis causes the smooth, elastic lining of the arteries to become hardened, stiffened and swollen by ' plaques ,' which are deposits of calcium, fats, and abnormal inflammatory cells. (verywell.com)
  • This is called atherosclerosis CAD can result in coronary heart disease also called ischemic heart disease. (guthrie.org)
  • Atherosclerosis in the coronary arteries is associated with a risk of future heart disease, and it is therefore important to find risk markers for atherosclerotic disease. (medindia.net)
  • Patients with reduced longitudinal displacement along the carotid artery have more extensive atherosclerosis in that artery, impaired heart function and a greater tendency to suffer from a shortage of oxygen in the heart. (medindia.net)
  • Today's methods look only at the thickness of the artery walls when identifying atherosclerosis," she said. (medindia.net)
  • Our technique shows that longitudinal displacement in the carotid artery reflects both the degree of atherosclerosis in the artery and heart function. (medindia.net)
  • Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. (medscape.com)
  • This test does not provide any insight regarding the presence of significant coronary atherosclerosis. (jci.org)
  • Called the Genetic Study of Atherosclerosis Risk (GeneSTAR), under way at Johns Hopkins since 1983, it involves participants who were all healthy upon enrollment, with no existing symptoms of heart disease. (scienceblog.com)
  • Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. (ovid.com)
  • Objective: Due to devastating consequences of coronary artery disease (CAD) in young population, this study was designed to evaluate the prevalence of preventable risk factors and severity of atherosclerosis for Iranian young adults (≤45 years) diagnosed with premature CAD. (scirp.org)
  • Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by decreased left ventricular function. (scirp.org)
  • Angina is most often a result of the narrowing of the coronary arteries caused by atherosclerosis--the buildup of cholesterol-rich fatty deposits, or plaques, on the inside of arterial walls. (wholehealthmd.com)
  • Narrowing of the arteries can be caused by a process known as atherosclerosis (most common), arteriosclerosis, or arteriolosclerosis. (wikipedia.org)
  • Coronary artery disease ( CAD ), also known as ischemic heart disease ( IHD ), [13] refers to a group of diseases which includes stable angina , unstable angina , myocardial infarction , and sudden cardiac death . (wikipedia.org)
  • Chest pain that occurs regularly with activity, after eating, or at other predictable times is termed stable angina and is associated with narrowings of the arteries of the heart . (wikipedia.org)
  • Angina can happen when too much plaque builds up inside arteries, causing them to narrow. (cdc.gov)
  • Nitrates can be used to treat angina, a common complication of coronary artery disease. (news-medical.net)
  • These hardened and narrow arteries may lead to symptoms such as angina, a pain in the chest which may be brought about by physical activity, emotional upset or even just eating a meal. (news-medical.net)
  • As the disease progresses, chest pain (angina pectoris) may develop during periods of physical activity or emotional stress, because the narrowed arteries cannot supply the heart with the increased amount of blood and oxygen necessary at those times. (healthcentral.com)
  • Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in the chest). (emoryhealthcare.org)
  • If you have a stable pattern of angina, other tests may be done to determine the severity of your disease. (bidmc.org)
  • This can cause chest pain (angina), shortness of breath, fatigue or other heart disease symptoms. (fda.gov)
  • The first sign of the disease is often chest pain (angina) or a heart attack. (intermountainhealthcare.org)
  • The most common symptom of coronary artery disease is angina (also called angina pectoris). (hubpages.com)
  • compared to men, women who present with acute coronary syndrome/unstable angina as well as stable angina are more likely to have non-obstructive CAD on coronary angiography, and yet have a high IHD morbidity and mortality. (springer.com)
  • Humphries KH, Pu A, Gao M, Carere RG, Pilote L. Angina with "normal" coronary arteries: sex differences in outcomes. (springer.com)
  • Ong P, Athanasiadis A, Borgulya G, Mahrholdt H, Kaski JC, Sechtem U. High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. (springer.com)
  • The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries). (springer.com)
  • Without enough blood, coronary artery disease can lead to angina (chest pain). (hopkinsmedicine.org)
  • Coronary artery disease can cause angina symptoms, such as chest pain or pressure. (healthwise.net)
  • Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. (clinicaltrials.gov)
  • The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm. (clinicaltrials.gov)
  • These plaques can protrude into the channel of the artery, causing a partial blockage of blood flow, a condition that often causes angina . (verywell.com)
  • In recent years, cardiologists have recognized that both myocardial infarctions and unstable angina are caused by the rupture of the plaques in coronary arteries . (verywell.com)
  • Surgical revascularization by coronary artery bypass grafting is recommended for those with significant left main coronary artery stenosis, significant stenosis of the proximal left anterior descending artery, multivessel coronary disease, or disabling angina. (aafp.org)
  • If you are experiencing the more classic symptoms of angina or a heart attack, your physician may recommend a coronary angiogram . (northshore.org)
  • Welcome to the Healing Center for Angina (Coronary Artery Disease). (wholehealthmd.com)
  • Angina is a primary symptom of coronary artery disease (CAD), the gradual narrowing of the arteries that supply heart muscles with oxygenated blood. (wholehealthmd.com)
  • In time, and especially if the disease is not controlled through lifestyle changes and medications, angina attacks may increase in frequency, intensity, or duration, or they may be triggered by less exertion. (wholehealthmd.com)
  • But when physical activity, such as running or climbing stairs, increases the heart's need for oxygen, the narrowed arteries now fail to meet the demand, and angina results. (wholehealthmd.com)
  • In some cases, angina attacks are not triggered by physical activity, but occur instead when a small blood clot forms on plaque-damaged arterial walls, temporarily blocking a coronary artery. (wholehealthmd.com)
  • this phenomenon is termed stable angina and is associated with narrowing of the arteries of the heart. (wikipedia.org)
  • Therefore, any disorder or disease of the coronary arteries can have a serious impact on health, possibly leading to angina, a heart attack, and even death. (wikipedia.org)
  • What are the symptoms of coronary artery disease? (cdc.gov)
  • If you're at high risk for heart disease or already have symptoms, your doctor can use several tests to diagnose CAD. (cdc.gov)
  • About 13 million Americans have active symptoms of coronary artery disease . (encyclopedia.com)
  • Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. (news-medical.net)
  • A lack of blood flow can cause chest pain, shortness of breath, and other symptoms of cardiac disease. (healthline.com)
  • Read more about how to identify the symptoms of coronary artery disease here. (healthline.com)
  • Such symptoms should not be ignored, especially in people at risk of heart disease by virtue of strong family history, habitual use of certain drugs (such as cocaine), and age (all people over the age of 40). (healthcentral.com)
  • In the early stages of the disease, there are generally no symptoms. (healthcentral.com)
  • Coronary artery disease can progress for years, even decades, without symptoms. (bidmc.org)
  • But as your arteries become more and more narrowed, symptoms can manifest. (bidmc.org)
  • Coronary artery disease is often referred to as the silent killer because symptoms can go undetected. (montgomeryadvertiser.com)
  • Imaging tools like coronary computed tomography angiography (CCTA) tend to be used in patients with symptoms or more advanced cardiovascular disease, but are not recommended for liberal use in risk assessment among the general population with no cardiac symptoms. (prweb.com)
  • Which symptoms of coronary artery disease need an immediate 911 call? (webmd.com)
  • Learn about coronary artery disease causes, risk factors, and symptoms. (intermountainhealthcare.org)
  • Treatment for coronary artery disease can help manage the symptoms and reduce the risk of further problems. (hubpages.com)
  • Nitrates, beta blockers, calcium channel blockers, aspirin, or cholesterol-lowering drugs (statins) are used to slow the disease progress or ease symptoms. (hubpages.com)
  • In the clinical setting, coronary artery disease diagnostics is often performed in a sequential manner, where the four diagnostic steps typically consist of evaluation of (1) signs and symptoms of the disease and electrocardiogram (ECG) at rest, (2) sequential ECG testing during the controlled exercise, (3) myocardial perfusion scintigraphy, and (4) finally coronary angiography, that is considered as the "gold standard" reference method. (springer.com)
  • Because coronary artery disease develops over time, the symptoms depend on the stage of illness. (hopkinsmedicine.org)
  • Treatment for coronary artery disease can help relieve symptoms and lower your risk of a heart attack. (healthwise.net)
  • Select patients with uncontrolled symptoms of stable CAD despite optimal medical management may benefit from coronary revascularization with percutaneous coronary intervention or coronary artery bypass grafting. (aafp.org)
  • symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). (clinicaltrials.gov)
  • Some people have no symptoms at all, which is fairly typical during the early stages of the disease. (cardiosmart.org)
  • Coronary artery disease develops over decades and may have no symptoms. (guthrie.org)
  • Symptoms of heart disease often reveal themselves during or after exercise or even after simple physical activities like walking up a flight of stairs. (northshore.org)
  • Lack of evident symptoms, though, doesn't lessen the importance of seeking medical advice, especially if you have a family history of heart disease and/or have high blood pressure, high LDL cholesterol levels or smoke, to name a few key risk factors. (northshore.org)
  • Advance testing for the genetic marker, she says, could ultimately in the future assist physicians in risk-stratifying those without inherited protection so they could be monitored more closely for early signs and symptoms of disease. (scienceblog.com)
  • A significant narrowing in your coronary arteries (the arteries supplying blood to your heart), also known as obstructive coronary artery disease (CAD), causes a decrease in blood flow resulting in associated symptoms like chest discomfort, shortness of breath, or heartburn. (healthywomen.org)
  • If you have symptoms suggestive of CAD, it's important to see your doctor so that he or she can determine the likelihood that you may have a significant narrowing in your coronary arteries. (healthywomen.org)
  • Coronary artery disease develops slowly, often with no symptoms at first. (wholehealthmd.com)
  • [10] Procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) may be used in severe disease. (wikipedia.org)
  • This is also called percutaneous coronary revascularization. (news-medical.net)
  • The treatment options this study will compare are: (1) Hybrid Coronary Revascularization [HCR] (a combination of surgery and catheter procedures to open up clogged heart arteries) and (2) Percutaneous Coronary Intervention [PCI] (catheter procedures alone to open up clogged heart arteries). (centerwatch.com)
  • The drug-eluting stents (DESs) are currently used in the majority of percutaneous coronary intervention (PCI) procedures. (centerwatch.com)
  • In the COACT trial, a strategy of immediate coronary angiography and percutaneous coronary intervention did not improve outcomes following successful resuscitation after out-of-hospital cardiac arrest in the absence of ST-segment elevation myocardial infarction. (nature.com)
  • 1 In the past few years, however, it has been increasingly challenged by percutaneous coronary intervention. (bmj.com)
  • Indeed, in many parts of the developed world percutaneous coronary intervention is done twice as often as coronary artery bypass grafting. (bmj.com)
  • Select patients may benefit from coronary revascularization with percutaneous coronary intervention or coronary artery bypass grafting. (aafp.org)
  • An RCT of 200 patients with severe single-vessel coronary stenosis (≥ 70%) found no differences between groups in exercise time or anginal relief six weeks after percutaneous coronary intervention or a sham procedure. (aafp.org)
  • Options for secondary prevention include medical therapy and surgical revascularization in the form of coronary artery bypass grafting or percutaneous coronary intervention. (aafp.org)
  • Percutaneous coronary intervention may be considered in select patients with objective evidence of ischemia demonstrated by noninvasive testing. (aafp.org)
  • Percutaneous coronary interventions have not been shown to be superior to optimal medical treatment alone for death or recurrent cardiovascular events in patients with stable CAD. (aafp.org)
  • and Revascularization Options: Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention. (elsevier.com)
  • The average age of men and women was 67 and roughly 25% had had a previous MI and roughly 43% at least one percutaneous coronary intervention. (medpagetoday.com)
  • Method: A cross sectional, descriptive study comprised 1093 consecutive patients (≤45 years), with a diagnosis of CAD, who underwent percutaneous intervention (PCI) or coronary bypass graft (CABG) from 2010 to 2012. (scirp.org)
  • Another procedure is coronary artery bypass grafting (CABG). (news-medical.net)
  • In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. (emoryhealthcare.org)
  • Coronary artery bypass graft (CABG) surgery (open-heart surgery) is often performed when multiple coronary arteries are blocked or when blockages are not suitable for angioplasty or stenting. (bidmc.org)
  • CABG surgery involves the usage of arteries or veins from other areas in your body to route blood flow around your narrowed coronary arteries. (bidmc.org)
  • CABG can sometimes be performed as a minimally invasive procedure if a patient has just one blocked artery that needs bypassing. (bidmc.org)
  • Patients with coronary artery disease (CAD) requiring coronary artery bypass grafting (CABG) are still at significant risk for postoperative major adverse cardiocerebral events (15% MACCE rate), with 3% of patients dying within 30 days of surgery. (centerwatch.com)
  • Learn about treatment options for coronary artery disease, including angioplasty, stent placement, and coronary artery bypass surgery (CABG). (intermountainhealthcare.org)
  • Treatment may also require surgical intervention, such as with angioplasty, stent replacement, coronary artery bypass graft surgery (CABG) or off-pump coronary artery bypass surgery. (hubpages.com)
  • Coronary Artery Bypass Surgery (CABG) is performed to restore the blood supply to areas of heart that have reduced or no blood supply due to blockage in the vessels. (medindia.net)
  • Coronary artery bypass grafting (CABG) or heart bypass surgery is an open heart surgery to relieve the blockages of the arteries of the heart. (medindia.net)
  • In cases of suspected heart disease, a coronary angiogram may be performed to assess the state of the coronary arteries. (news-medical.net)
  • Coronary angiogram checks your arteries for flow and blockage. (familydoctor.org)
  • TAKEDA EXAMINE trial patients for who have Type II diabetes & ACS coronary artery disease, post angiogram or heart attack. (centerwatch.com)
  • You may also have a coronary angiogram to check blood flow to the heart. (rexhealth.com)
  • Some of the tests or procedures that may be done include a blood test, electrocardiogram, ultrasound of heart, stress test, CT scan or Coronary angiogram. (montgomeryadvertiser.com)
  • Methods: In this cross sectional study, 233 patients planned for valvular heart surgery and aged 40 years or more were subjected to preoperative coronary angiogram. (doaj.org)
  • Coronary artery disease is frequently asymptomatic, and its diagnosis relies on performance of a coronary angiogram. (jci.org)
  • Of note, the proband of family 1 had a transient ischemic attack ( 1 ), which raises the issue of atherosclerotic vascular disease, and only 2 other individuals in the family were old enough to be properly categorized - only 1 of these had an exercise stress test, and none had a coronary angiogram. (jci.org)
  • A number of tests may help with diagnoses including: electrocardiogram, cardiac stress testing, coronary computed tomographic angiography, and coronary angiogram, among others. (wikipedia.org)
  • Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood flow to the heart in people with severe coronary artery disease . (healthlinkbc.ca)
  • The U.S. Food and Drug Administration today approved the first fully absorbable stent to treat coronary artery disease. (fda.gov)
  • Doctors often treat coronary artery disease with a procedure called angioplasty to widen the artery using a metal stent. (fda.gov)
  • Many medications may be used to treat coronary artery disease including aspirin and statins that help lower cholesterol and prevent plaque formation. (montgomeryadvertiser.com)
  • Another procedure performed to treat coronary artery disease is a surgery called Coronary Artery Bypass Grafting A healthy blood vessel (called a graft) is inserted into the aorta and attached to the blocked coronary artery just distal to the blockage and restores normal blood flow to the heart. (montgomeryadvertiser.com)
  • Anticoagulants are not typically used to treat coronary artery disease. (healthlinkbc.ca)
  • CAD is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. (cdc.gov)
  • The disease process in arteries is thought to begin with an injury to the linings and walls of the arteries. (encyclopedia.com)
  • MRI can detect thickening in the walls of the arteries, a change that occurs earlier in the course of heart disease than stenosis, or narrowing of the arteries. (prweb.com)
  • Coronary artery disease is the inflammation of the walls of the arteries. (sharecare.com)
  • This occurs when plaques (made up of deposits of cholesterol and other substances) build up over time in the walls of the arteries. (wikipedia.org)
  • It is sometimes called coronary heart disease or ischemic heart disease. (cdc.gov)
  • Coronary artery disease (CAD), also known as coronary heart disease (CHD), ischemic heart disease (IHD), or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of plaque in the arteries of the heart. (dbpedia.org)
  • Coronary heart disease and ischemic heart disease are other names for CAD. (healthgrades.com)
  • Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease," Hypertension , vol. 38, no. 5, pp. 1054-1061, 2001. (hindawi.com)
  • The Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) also reported a standardized mortality ratio (SMR) from ischemic heart disease of 9.1 (for men) and 13.5 (for women) for those with a diabetes diagnosis before 30 years of age ( 5 ). (diabetesjournals.org)
  • In those aged 20-29 years, SMRs for ischemic heart disease mortality of 11.8 in men and 44.8 in women were reported, while for those aged 30-39 years, SMRs were 8.0 and 41.6, respectively. (diabetesjournals.org)
  • Coronary artery disease (CAD), also called ischemic heart disease, occurs due to the narrowing of coronary arteries that supply oxygen-rich blood to the heart. (reportlinker.com)
  • Ischemic heart disease (IHD) continues to be a major health threat to women worldwide. (springer.com)
  • Ischemic heart disease in women: a focus on risk factors. (springer.com)
  • 2012). ACCF/AHA/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. (healthwise.net)
  • Coronary artery disease (CAD) or ischemic heart disease (IHD) are the terms used to describe narrowing of the coronary arteries. (wikipedia.org)
  • Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary arteries). (cdc.gov)
  • Plaque buildup causes the inside of the arteries to narrow over time. (cdc.gov)
  • Plaque buildup causes the inside of the arteries to narrow over time, which can partially or totally block the blood flow. (cdc.gov)
  • A computed tomography (CT) scan that looks in the coronary arteries for calcium buildup and plaque. (cdc.gov)
  • Like gunk in a clogged drainpipe, this buildup prevents a free flow of blood through the arteries. (webmd.com)
  • The most frequent cause of CAD is injury and plaque buildup in these vessels, which are called coronary arteries. (healthline.com)
  • CHD is plaque buildup in your arteries. (familydoctor.org)
  • This buildup causes the inside of the arteries to become narrower and slows down the flow of blood. (reference.com)
  • These together can cause calcium to buildup in corona arteries. (montgomeryadvertiser.com)
  • Coronary plaque buildup may progress more quickly in patients with diabetes compared with those without diabetes, according to research results published in Clinical Cardiology and presented at the 3rd Annual Heart in Diabetes Conference, held July 12 to 14, 2019, in Philadelphia, Pennsylvania. (hubpages.com)
  • A blockage is caused by a buildup of plaque inside the artery walls. (sandrarose.com)
  • As the disease progresses, plaque buildup can partially block blood flow to the heart muscle. (wikipedia.org)
  • Unlike CAD, spontaneous coronary artery dissection is not due to plaque buildup in arteries, and tends to occur in younger individuals, including women who have recently given birth or men who do intense exercise. (wikipedia.org)
  • Coronary artery disease (CAD) is the most common type of heart disease in the United States. (cdc.gov)
  • Narrowed arteries can cause chest pain because they can block blood flow to your heart muscle and the rest of your body. (cdc.gov)
  • Learn the facts about heart disease , including coronary artery disease, the most common type of heart disease. (cdc.gov)
  • A family history of heart disease also increases your risk for CAD, especially a family history of having heart disease at an early age (50 or younger). (cdc.gov)
  • Checks the inside of your arteries for blockage by inserting a thin, flexible tube through an artery in the groin, arm, or neck to reach the heart. (cdc.gov)
  • Health care professionals can measure blood pressure within the heart and the strength of blood flow through the heart's chambers as well as collect blood samples from the heart or inject dye into the arteries of the heart (coronary arteries). (cdc.gov)
  • Coronary artery disease is a narrowing or blockage of the arteries and vessels that provide oxygen and nutrients to the heart. (encyclopedia.com)
  • Coronary artery disease, also called coronary heart disease or heart disease , is the leading cause of death for both men and women in the United States . (encyclopedia.com)
  • According to the American Heart Association, deaths from coronary artery disease have declined some since about 1990, but more than 40,000 people still died from the disease in 2000. (encyclopedia.com)
  • This blockage limits the flow of blood from the coronary arteries, which are the major arteries supplying oxygen-rich blood to the heart. (encyclopedia.com)
  • The coronary arteries expand when the heart is working harder and needs more oxygen. (encyclopedia.com)
  • The artery walls are flexible and can expand to let more blood through when the heart needs to work harder. (encyclopedia.com)
  • Coronary artery disease describes a condition where the coronary arteries that supply the heart with oxygen and nutrients become hardened and narrowed. (news-medical.net)
  • Eventually, the plaque can harden the artery wall causing it to narrow, reducing the blood flow and supply of oxygen and nutrients to the heart. (news-medical.net)
  • For this test, a special dye is injected into the blood vessels and images of the heart are obtained that show how blocked the arteries are. (news-medical.net)
  • It's the most common type of heart disease. (webmd.com)
  • The trouble starts when a waxy substance called plaque builds up inside the arteries that supply blood to the heart muscle. (webmd.com)
  • Coronary artery disease (CAD) , also called coronary heart disease, is the most common type of heart disease . (healthline.com)
  • In the United States, heart disease is the leading cause of death, with CAD being the most common type of heart disease. (healthline.com)
  • Heart disease is one type of cardiovascular disease. (healthline.com)
  • There are rare causes of damage or blockage to a coronary artery that can also limit blood flow to the heart. (healthline.com)
  • In the event of a heart attack, your heart muscle will start to die within the territory downstream from the blocked coronary artery. (healthline.com)
  • What Is Coronary Heart Disease? (healthcentral.com)
  • Coronary heart disease (CHD)-also sometimes called coronary artery disease-is the most common form of cardiovascular disease, a group of disorders that involve the heart and blood vessels. (healthcentral.com)
  • CHD is a narrowing of the coronary arteries, the vessels that supply oxygenated blood (fuel) to the heart muscle. (healthcentral.com)
  • In CHD, narrowed coronary arteries limit the supply of oxygenated blood to portions of the heart muscle. (healthcentral.com)
  • If narrowing is not extensive, difficulties may occur only during physical exertion, when the narrowed arteries are unable to meet the increased oxygen requirements of the heart. (healthcentral.com)
  • However, as the disease worsens, the narrowed arteries may starve the heart muscle of oxygen during periods of normal activity, or even at rest. (healthcentral.com)
  • The clots may block the narrowed coronary artery completely and cause a heart attack. (healthcentral.com)
  • Who Gets Coronary Heart Disease? (healthcentral.com)
  • Coronary arteries supply oxygen-rich blood to the heart muscle. (emoryhealthcare.org)
  • When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. (emoryhealthcare.org)
  • It may be that these new cardiovascular risk factors are responsible for accelerating coronary heart disease in patients with RA. (nih.gov)
  • That would cause a lack of oxygen, or ischemia, in the part of the heart the artery supplies. (medlineplus.gov)
  • Arteries carry blood and oxygen to your heart. (familydoctor.org)
  • Coronary heart disease develops over time. (familydoctor.org)
  • How is coronary heart disease diagnosed? (familydoctor.org)
  • Cardiac computed tomography (CT) scan produces an image of your heart and arteries. (familydoctor.org)
  • Can coronary heart disease be prevented or avoided? (familydoctor.org)
  • They say this artery is going directly into the middle of the heart.They explained to me about the 3rd artery. (medhelp.org)
  • Heart Disease and Saturated Fat: Do the Dietary Guidelines Have It All Wrong? (medhelp.org)
  • Can Mental Stress Lead to Heart Disease? (medhelp.org)
  • Can depression and anxiety cause heart disease? (medhelp.org)
  • Your coronary arteries are the large blood vessels that supply your heart muscle with oxygen-rich blood. (bidmc.org)
  • CAD, which typically builds up over decades, is the most common form of heart disease and is the leading cause of heart disease-related death worldwide. (bidmc.org)
  • Family history of heart disease: your risk increases if your father or brother was diagnosed with CAD before age 55, or your mother was diagnosed before age 65. (bidmc.org)
  • A complete blockage in an artery can cause a heart attack. (bidmc.org)
  • Coronary heart disease is responsible for about 370,000 deaths each year in the U.S., according to the National Heart, Lung, and Blood Institute. (fda.gov)
  • The condition develops when cholesterol-containing deposits build up and narrow the coronary arteries, decreasing blood flow to the heart. (fda.gov)
  • Coronary artery disease (CAD) is the disease of blood vessels in the heart. (centerwatch.com)
  • The primary purpose of this study is to evaluate whether treatment with rivaroxaban and aspirin or rivaroxaban alone is better than aspirin alone in prevention of heart attacks, stroke or cardiovascular death in patients with coronary or peripheral artery disease. (centerwatch.com)
  • Coronary heart disease is a common form of heart disease and is a major cause of illness and death . (rxlist.com)
  • Coronary heart disease begins when hard cholesterol substances (plaques) are deposited within a coronary artery. (rxlist.com)
  • The coronary arteries arise from the aorta , which is adjacent to the heart. (rxlist.com)
  • The plaques narrow the internal diameter of the arteries (Figure1) which may cause a tiny clot to form which can obstruct the flow of blood to the heart muscle (Figure 2). (rxlist.com)
  • What is the purpose of screening tests for coronary heart disease? (rxlist.com)
  • In many individuals, the first symptom of coronary heart disease is heart attack or sudden death, with no preceding chest pain as a warning. (rxlist.com)
  • For this reason, doctors perform screening tests to detect signs of coronary heart disease before serious medical events occur so the tests are designed to detect plaque (Figure 1) before a coronary artery becomes completely blocked (Figure 2). (rxlist.com)
  • Screening tests are of particular importance for people with risk factors for coronary heart disease. (rxlist.com)
  • These risk factors include a family history of coronary heart disease at relatively young ages, an abnormal serum cholesterol profile, cigarette smoking , elevated blood pressure ( hypertension ), and diabetes mellitus . (rxlist.com)
  • What are common initial screening tests for coronary heart disease? (rxlist.com)
  • An electrocardiogram (EKG, ECC) usually is the first and most simple test used to look for any coronary heart disease signs. (rxlist.com)
  • Unless the person is actively having a heart attack, which often is seen as an electrical change in the heart rhythm (ST segment elevation), the EKG may show electrical changes such as ST depressions or Q waves that suggest the patient has coronary heart disease or coronary heart disease with signs of a previous heart attack. (rxlist.com)
  • Initial screening for coronary heart disease commonly involves stressing the heart under controlled conditions. (rxlist.com)
  • If a coronary arterial blockage results in decreased blood flow to a part of the heart during exercise, certain changes (for example, ST segment depressions) may be observed in the EKG, as well as in the response of the heart rate and blood pressure. (rxlist.com)
  • The accuracy of the ECST in predicting significant coronary heart disease is variable, depending in part on the "pre-test likelihood" of coronary heart disease (also known as Bayes' theorem ). (rxlist.com)
  • In a person at high risk for coronary heart disease (for example, advanced age, multiple coronary risk factors), an abnormal ECST is very predictive of the presence of coronary heart disease (over 90% accurate). (rxlist.com)
  • High blood pressure, menopause, and obesity - these are some ​​modifiable risk factors for coronary heart disease. (reference.com)
  • Coronary artery disease (CAD) is the most common form of heart disease. (healthgrades.com)
  • CAD affects the arteries that supply blood to the heart muscle. (healthgrades.com)
  • As the disease continues, the heart struggles to work without enough oxygen. (healthgrades.com)
  • Heart attack happens when blood flow through a coronary artery becomes completely blocked. (healthgrades.com)
  • Coronary artery disease (CAD) causes impaired blood flow in the arteries that supply blood to the heart. (healthline.com)
  • Also called coronary heart disease (CHD), CAD is the most common form of heart disease and affects approximately 16.5 million Americans over the age of 20. (healthline.com)
  • These arteries bring oxygen and nutrient-rich blood to your heart . (healthline.com)
  • Men have a higher risk of developing heart disease than premenopausal women. (healthline.com)
  • Whether or not you have had a heart attack, there are many things you can do to slow coronary artery disease and reduce your risk of future problems. (rexhealth.com)
  • When it occurs in the ones that supply blood to the heart ( the coronary arteries ), it is called coronary artery disease. (rexhealth.com)
  • When plaque builds up in the coronary arteries, the heart may not get the blood it needs to work well. (rexhealth.com)
  • A heart attack is sometimes the first sign of coronary artery disease. (rexhealth.com)
  • and having heart disease in your family. (rexhealth.com)
  • If your doctor thinks that you have coronary artery disease, you may have tests to check how well your heart is working. (rexhealth.com)
  • Gray hair and heart disease: Mayo Clinic Radio Health Minute Dec. 04, 2019, 02:58 p.m. (mayoclinic.org)
  • Coronary artery disease is a build-up of plaque in the arteries, which restricts the flow of oxygen-rich blood and nutrients to the heart. (montgomeryadvertiser.com)
  • Stressed induced coronary heart disease is just common in men as it is in women. (montgomeryadvertiser.com)
  • Death by heart disease is the most common death in the United States. (montgomeryadvertiser.com)
  • Heart disease affects an estimated 15 million Americans and is the leading cause of death for women and men around the world. (montgomeryadvertiser.com)
  • In the United States, coronary artery disease accounts for approximately 370,000 deaths each year, according to the National Heart, Lung and Blood Institute. (montgomeryadvertiser.com)
  • Fatigue, pain in the limbs, nausea and chest pain could signal a blockage of the arteries that can cause a heart attack. (montgomeryadvertiser.com)
  • The thickness of the coronary artery wall as measured by MRI is an independent marker for heart disease in women, according to a study published online, April 25, in the journal Radiology: Cardiothoracic Imaging. (prweb.com)
  • For instance, there is evidence that the commonly used Framingham Risk Score, which provides estimates of cardiovascular disease risk based on age, sex and other factors, underestimates the chance of heart attacks and other cardiovascular events in asymptomatic women. (prweb.com)
  • Over a period of years, Dr. Abd-Elmoniem and colleagues developed and refined an MRI technique that adjusts for the motions of breathing and the beating heart to directly visualize coronary wall thickness. (prweb.com)
  • If the problem is not addressed, the arteries can become so clogged that a heart attack can occur. (empowher.com)
  • He explained that Millie had coronary artery disease - narrowing of the arteries in her heart. (medtronic.com)
  • Unfortunately for Millie, she had a family history of heart disease. (medtronic.com)
  • We took 200 patients," says Dr. Puskas, "who had every sort of degree of heart disease: coronary blockages, reduced ventricular function, or heart failure, and we randomized them to have their operations with or without the heart-lung machine, that is to say stopped heart surgery or beating heart surgery. (medtronic.com)
  • Coronary artery disease is the most common type of heart disease, according to the Centers for Disease Control and Prevention. (eurekalert.org)
  • CT is particularly useful for high-resolution images of the coronary anatomy, while cardiac MRI can provide information on blood supply to the heart muscle without exposing patients to ionizing radiation. (eurekalert.org)
  • Information from the 3D fused image helped correlate specific stenoses, or areas of narrowing in the coronary arteries, and their severity with possible cardiac scar tissue and ischemia--a condition in which parts of the heart muscle don't get enough blood. (eurekalert.org)
  • Angiotensin-converting enzyme gene polymorphism in coronary artery disease in North India," Indian Heart Journal , vol. 56, no. 1, pp. 44-46, 2004. (hindawi.com)
  • Association of endothelial constitutive nitric oxide synthase gene polymorphism with acute coronary syndrome in Koreans," Heart , vol. 90, no. 3, pp. 282-285, 2004. (hindawi.com)
  • Even if you have smoked for many years, if you quit, you can cut your chances of having a coronary heart disease event (such as a heart attack) in half within a year or two of quitting. (healthcentral.com)
  • it is the pressure in the arteries while the heart is pumping blood. (healthcentral.com)
  • it indicates pressure in the arteries while the heart relaxes between beats. (healthcentral.com)
  • Whether you have prehypertension or hypertension, lowering your blood pressure not only will reduce your likelihood of developing coronary artery disease but also can lower your risk of having a heart attack or stroke, or developing heart failure. (healthcentral.com)
  • The Systolic Blood Pressure Intervention Trial (SPRINT) found that maintaining systolic blood pressure in the 120 to 125 mm Hg range was associated with significantly fewer atherosclerotic cardiovascular disease events (such as heart attack or stroke) than keeping it in the 135 to 140 mm Hg range. (healthcentral.com)
  • High blood levels of total cholesterol, LDL cholesterol, and triglycerides and low levels of HDL cholesterol increase your risk of coronary heart disease. (healthcentral.com)
  • Although the increased risk of premature heart disease in type 1 diabetes has been recognized for some time, the underlying pathogenesis is still poorly understood. (diabetesjournals.org)
  • However, despite recent evidence from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study that prior intensive glycemic control reduces cardiovascular disease (CVD), the epidemiologic association between glycemia and coronary heart disease (CHD) is surprisingly weak. (diabetesjournals.org)
  • In coronary artery disease, the coronary arteries become narrowed or blocked, which reduces blood flow to the heart. (heartandstroke.ca)
  • Risk factors for heart disease are conditions or habits that make it more likely that you will get heart disease. (heartandstroke.ca)
  • Age - the older you are, the higher your risk of heart disease. (heartandstroke.ca)
  • Sex - Your risk of heart disease and stroke increases after menopause. (heartandstroke.ca)
  • Family history - if you have a close relative who has experienced heart disease at an early age, you are at an increased risk. (heartandstroke.ca)
  • They are at greater risk of heart disease than the general population. (heartandstroke.ca)
  • South Asian and African heritage - people of African or South Asian heritage also have a higher risk of heart disease. (heartandstroke.ca)
  • This is because they are more likely to have high blood pressure (hypertension), diabetes or other risk factors for heart disease at a younger age. (heartandstroke.ca)
  • But the clot can block the artery, leading to either a heart attack or stroke. (heartandstroke.ca)
  • You can lower your risk of coronary artery disease, heart disease and stroke by knowing and controlling your blood pressure, diabetes and blood cholesterol. (heartandstroke.ca)
  • Eat a healthy balanced diet - there are some specific diets you can follow that have been proven to reduce the risk of heart disease. (heartandstroke.ca)
  • To find useful services to help you on your journey with heart disease, see our services and resources listing . (heartandstroke.ca)
  • Coronary artery disease (CAD) is a narrowing of the coronary arteries that supply blood and oxygen to the heart. (intermountainhealthcare.org)
  • CAD is the most common form of heart disease, affecting around 17 million Americans. (intermountainhealthcare.org)
  • Despite these grim facts, most people can live full and rewarding lives with heart disease. (intermountainhealthcare.org)
  • Preventing coronary artery disease takes proper screening and a heart-healthy lifestyle. (intermountainhealthcare.org)
  • Coronary artery disease (CAD) affects the arteries that deliver blood and oxygen to the heart muscle. (intermountainhealthcare.org)
  • The results of a study involving 12,986 men and women (45-64 years old at baseline) provide evidence that anger may predict coronary heart disease (CHD). (chiroweb.com)
  • It might mean the difference in staying healthy instead of suffering from heart disease. (chiroweb.com)
  • It is also known as coronary heart disease (CHD), or simply, heart disease. (hubpages.com)
  • It is a condition which affects the arteries that supply the heart with blood. (hubpages.com)
  • The ideal blood cholesterol level for you depends on your age, gender, and history of heart disease, but for most people with coronary artery disease, the target LDL cholesterol level is 100 mg/dL or below, and the target HDL cholesterol level is above 40 mg/dL for men, and above 50 mg/dL for women. (hubpages.com)
  • Myocardial infarctions (heart attacks), arrhythmia, heart failure and stroke are among several serious complications of coronary artery disease. (hubpages.com)
  • These arteries bring blood to the heart muscle. (denverhealth.org)
  • Sanders, who is one of the leading candidates to challenge President Trump in 2020, underwent emergency surgery to have two stents inserted into one of his coronary arteries that feeds blood to the external muscle of the heart. (sandrarose.com)
  • The blockage causes narrowing in the artery that interrupts the flow of blood to the heart muscle, leading to death of the heart muscle. (sandrarose.com)
  • The illustration shows the positions of the left and right coronary arteries on the external wall of the heart. (sandrarose.com)
  • The recent untimely deaths of Internet stars Auntie Fee (pictured above) and Q Worldstar serve as reminders that heart disease is the number 1 killer of men and women in the U.S. (sandrarose.com)
  • For many people the first sign or symptom of heart disease is death. (sandrarose.com)
  • This is why heart disease is called the silent killer. (sandrarose.com)
  • Former President George Bush underwent a procedure earlier today to place a coronary stent in a blocked coronary artery in his heart. (sandrarose.com)
  • The coronary stent will keep the artery open to allow adequate blood flow in his heart. (sandrarose.com)
  • Plaque builds up within the coronary artery walls until the flow of oxygen-rich blood to the heart muscle is limited. (reportlinker.com)
  • In chronic ischemia, the coronary artery narrows over time, limiting the blood flow to part of the heart muscle, while acute ischemia occurs due to a sudden rupture of plaque and formation of a blood clot. (reportlinker.com)
  • Background:To study the prevalence of coronary artery disease (CAD) in patients undergoing valve surgery for rheumatic and non-rheumatic valvular heart disease. (doaj.org)
  • Logistic regression analysis was used to study predictive factors for CAD in valvular heart disease. (doaj.org)
  • 56% of patients had RHD, while 21% had degenerative valvular heart disease. (doaj.org)
  • The overall prevalence of CAD was found to be 31.3% in valvular heart disease (VHD). (doaj.org)
  • For the past two decades coronary artery bypass grafting has been the standard treatment for patients with severe multivessel ischaemic heart disease. (bmj.com)
  • Of patients in the study with obstructive heart disease, 30,160 were being treated with statins, another 2,042 had been prescribed only nonstatin lipid-lowering medications, and 6,441 got both. (medpagetoday.com)
  • Coronary artery disease (also called coronary heart disease ) is the number-one killer of both men and women in the United States, and it's the most common type of heart disease. (hopkinsmedicine.org)
  • This often preventable disease causes the dangerous thickening and narrowing of the coronary arteries-the vessels that bring blood to the heart-which disrupts the flow of oxygen and nutrients to the heart, causing serious problems. (hopkinsmedicine.org)
  • The damaged arteries may become completely blocked, or become prone to clotting, causing a heart attack. (hopkinsmedicine.org)
  • Coronary artery disease develops slowly, usually over decades, so the good news is that we have a huge window of opportunity for prevention, through a good lifestyle and healthy habits," says Seth Martin, M.D., M.H.S. , of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. (hopkinsmedicine.org)
  • Ideally, prevention habits start early, but they remain important all through life," Bill McEvoy , MBBCh, of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease says. (hopkinsmedicine.org)
  • This test may be considered in persons without known coronary heart disease in whom the decision to treat with a statin and aspirin is unclear. (hopkinsmedicine.org)
  • Peripheral Vascular Disease Understand more about diseases and disorders of the blood vessels outside of the heart. (cardiosmart.org)
  • There are many risk factors for heart disease that you can change. (cardiosmart.org)
  • It happens when your coronary arteries-which act like fuel lines to supply blood to the heart-become damaged or diseased. (cardiosmart.org)
  • The size and density of coronary artery calcium have contrasting effects on risk for heart disease. (cardiosmart.org)
  • Adults at low risk for heart disease consistently benefit from counseling that promotes exercise and a healthy diet. (cardiosmart.org)
  • Breastfeeding, especially for longer durations, helps reduce women's risk for heart disease. (cardiosmart.org)
  • Unsaturated fats can reduce cholesterol levels and reduce risk for heart disease and stroke. (cardiosmart.org)
  • Is Coronary Heart Disease on the Decline? (sharecare.com)
  • What Is the Prevalance of Cornary Heart Disease? (sharecare.com)
  • Are We Doing a Better Job Treating Heart Disease? (sharecare.com)
  • Is Baby Aspirin a Wonder Drug for Heart Disease? (sharecare.com)
  • How Does Inflammation in the Body Contribute to Heart Disease? (sharecare.com)
  • In particular, reducing cocaine use leads to regression of unstable, noncalcified coronary plaques--the type most likely to cause a heart attack or stroke, according to the new research by Dr. Shenghan Lai of Johns Hopkins School of Medicine, Baltimore, and colleagues. (eurekalert.org)
  • Heart disease and stroke statistics-2013 update: a report from the American Heart Association," Circulation , vol. 127, no. 1, pp. e6-e245, 2013. (hindawi.com)
  • The journal publishes basic research that has clinical applicability in order to promote timely communication of the latest insights relating to coronary artery disease, heart failure, hypertension, cardiac arrhythmia, prevention of cardiovascular disease with a heavy emphasis on risk factor modification. (ingentaconnect.com)
  • Coronary artery disease-known as CAD for short-affects more than 15 million American adults, making it the most common type of heart disease. (cardiosmart.org)
  • Really anyone with risk factors for heart disease can develop CAD. (cardiosmart.org)
  • Although you can't pick your parents to change your genetic risk for heart disease - and your age is what it is - there are many risk factors for heart disease that you can change to help protect yourself. (cardiosmart.org)
  • For others, chest pain or chest pressure-or even a heart attack-might be the first sign of blockages in the heart's arteries. (cardiosmart.org)
  • Severe narrowing or blockage of an artery can also lead to heart attack, which can happen when plaque ruptures into the artery and a clot forms to heal the injury. (cardiosmart.org)
  • These are risk factors for heart disease that can be modified with lifestyle changes and, if needed, medication. (cardiosmart.org)
  • These substances are carried to the heart muscle by the coronary arteries , thus allowing the heart to be imaged with a special camera. (verywell.com)
  • If one or more of the coronary arteries are partially blocked, the areas of heart muscle supplied by those arteries show up on the image as dark spots. (verywell.com)
  • The movement of the carotid artery can reveal the risk of a future heart attack, and a thesis from the University of Gothenburg, Sweden, says it is now possible to study this vessel aspect in more detail. (medindia.net)
  • This new method may therefore give us additional information and enable us to predict which patients run an increased risk of future heart disease. (medindia.net)
  • It involves the insertion of a long thin flexible tube called catheter a vein or an artery to the heart. (medindia.net)
  • A stress test is used to test for heart disease. (medindia.net)
  • Our heart arteries are surrounded by fat. (medindia.net)
  • Consumption of nuts was associated with a 13% to 19% lower risk of total cardiovascular disease and 15% to 23% lower risk of coronary heart disease. (greenmedinfo.com)
  • Geum joponicum extracts may provide a novel therapeutic method for effective treatment of chronic coronary heart disease. (greenmedinfo.com)
  • Heart disease accounts for one in every four deaths in the United States. (northshore.org)
  • Surrounding the heart, the coronary arteries work to supply this vital organ with oxygen-rich blood. (northshore.org)
  • While a serious health concern, coronary heart disease is treatable and preventable ‒ as long as you listen to your body's warning signs. (northshore.org)
  • Keep in mind that not everyone with coronary artery disease will exhibit overt signs of a heart attack. (northshore.org)
  • This issue of the Heart Failure Clinics provides a contemporary and concise, yet extensive, review on all aspects of the management of patients with coronary artery disease. (elsevier.com)
  • 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (medscape.com)
  • They were 10 times less likely to have coronary heart disease, which disproportionately afflicts a greater number of African-Americans than whites or any other ethnic group. (scienceblog.com)
  • All were monitored for at least five years with periodic check-ups to see who developed heart disease and who did not. (scienceblog.com)
  • Talk with your doctor about the best ways to lower your risk of heart disease. (healthwise.net)
  • Heart-healthy eating can help lower risk of heart disease, heart attack, and stroke. (healthwise.net)
  • These diets could cause serious medical problems, especially if you have heart disease, type 2 diabetes , high cholesterol , or high blood pressure . (healthwise.net)
  • It is clear that taking some vitamins and supplements does not lower the risk of heart disease, heart attack, and stroke. (healthwise.net)
  • Doctors used to think that hormone therapy for women could lower the risk of getting heart disease. (healthwise.net)
  • But hormone therapy does not prevent heart disease. (healthwise.net)
  • Severe narrowing or complete blockage of the coronary vessels can lead to a heart attack or even death. (healthywomen.org)
  • A new study found that the Y chromosome-the male chromosome-has a role in the inheritance of this most common type of heart disease. (emaxhealth.com)
  • The investigators reported on their findings of the four-year study, during which they analyzed DNA from more than 3,000 men who participated in the British Heart Foundation Family Heart Study and the West of Scotland Coronary Prevention Study. (emaxhealth.com)
  • This risk is independent of risk factors associated with heart disease, such as obesity, smoking, high cholesterol, and high blood pressure. (emaxhealth.com)
  • Coronary artery disease (also called coronary heart disease) is characterized by the hardening and narrowing of blood vessels that transport blood to the heart. (emaxhealth.com)
  • Over time, coronary artery disease can weaken the heart muscle and contribute to irregular heart rhythm (arrhythmia) and heart failure. (emaxhealth.com)
  • In 2008, coronary artery disease was responsible for 88,236 deaths in the United Kingdom, according to the British Heart Foundation, affecting more men (49,665) than women (38,571). (emaxhealth.com)
  • According to Dr. Helene Wilson, research advisor at the British Heart Foundation , "This study shows that genetic variations on the Y chromosome-the piece of DNA that only men have-can increase a man's risk of coronary heart disease. (emaxhealth.com)
  • It's known that males typically develop heart disease about a decade before women do, but the reason has not been determined. (emaxhealth.com)
  • The results of this study suggest that sex matters, or at least the Y chromosome, when it comes to coronary artery disease, and that researchers need to "further analyze the human Y chromosome to find specific genes and variants" behind the association between sex and heart disease. (emaxhealth.com)
  • It's caused by a blockage in any of the arteries that nourish your heart. (wholehealthmd.com)
  • As plaques develop, the coronary arteries thicken and narrow over time, impeding the flow of oxygenated blood to the heart muscles. (wholehealthmd.com)
  • During rest, the narrowed arteries may still be wide enough to supply the heart with the oxygen it requires. (wholehealthmd.com)
  • Bypass surgery is not a cure for heart disease. (healthlinkbc.ca)
  • The surgery doesn't change the way arteries harden or narrow because of heart disease. (healthlinkbc.ca)
  • The narrowing of coronary arteries reduces the supply of oxygen-rich blood flowing to the heart, which becomes more pronounced during strenuous activities during which the heart beats faster. (wikipedia.org)
  • The coronary arteries are the arterial blood vessels of coronary circulation, which transport oxygenated blood to the heart muscle. (wikipedia.org)
  • The coronary arteries wrap around the entire heart. (wikipedia.org)
  • The arteries can additionally be categorized based on the area of the heart they provide circulation for. (wikipedia.org)
  • Reduced function of the coronary arteries can lead to decreased flow of oxygen and nutrients to the heart. (wikipedia.org)
  • Aorta Left coronary artery (LCA) Left anterior descending artery Left circumflex artery Posterior descending artery Ramus or intermediate artery Right coronary artery (RCA) Right marginal artery Posterior descending artery The left coronary artery (LCA) arises from the aorta within the left cusp of the aortic valve and feeds blood to the left side of the heart. (wikipedia.org)
  • It travels down the right coronary sulcus, towards the crux of the heart. (wikipedia.org)
  • There is also the conus artery, which is only present in about 45 percent of the human population, and which provides collateral blood flow to the heart when the left anterior descending artery is occluded. (wikipedia.org)
  • Atherosclerotic plaques often form blood clots that also can block the coronary arteries (coronary thrombosis). (encyclopedia.com)
  • Prevalence of type 2 diabetes in Asia seems to be almost epidemic and establishment of preventive strategy against macrovascular as well as microvascular diseases are warranted because of higher cardiovascular risk in diabetic patients even without history of atherosclerotic cardiovascular diseases. (centerwatch.com)
  • Decreased cocaine use was followed by regression of atherosclerotic plaques in the coronary arteries. (eurekalert.org)
  • The prevalence of atherosclerotic coronary artery disease (CAD) is increased in patients with chronic inflammatory rheumatic diseases, particularly rheumatoid arthritis (RA) and systemic lupus erythematosus [ 1 ]. (uptodate.com)
  • Perivascular fat attenuation index can be used to monitor development and progress of coronary artery disease and to differentiate stable from unstable atherosclerotic plaques. (medindia.net)
  • One coronary intervention is coronary angioplasty and stent placement. (news-medical.net)
  • The FDA's approval of the Absorb GT1 BVS offers a new treatment option for individuals who are candidates for angioplasty, but would prefer an absorbable device rather than a permanent metallic coronary stent," said Bram Zuckerman, M.D., director of the division of cardiovascular devices at the FDA's Center for Devices and Radiological Health. (fda.gov)
  • The most common procedure to open blocked arteries is angioplasty, and placing a device called stent. (montgomeryadvertiser.com)
  • At first, she assumed that she was headed for another angioplasty procedure, but her cardiologist was concerned about one of her coronary arteries. (medtronic.com)
  • The purpose of the catheterization is to fully characterize the location and extent of all coronary artery blockages , usually for the purpose of angioplasty , stenting or bypass surgery . (verywell.com)
  • Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor, more frequently clopidogrel, represents the standard of care for the long-term secondary prevention of atherothrombotic events in patients with myocardial infarction (MI) or peripheral arterial disease (PAD). (centerwatch.com)
  • Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarction in middle-aged men," Journal of Molecular Medicine , vol. 80, no. 9, pp. 605-609, 2002. (hindawi.com)
  • High levels of anger contributed to an increased risk of CHD and other coronary events, including acute myocardial infarction (MI) and fatal CHD. (chiroweb.com)
  • These blood clots can completely or mostly block the flow of blood through the artery, leading to acute myocardial ischemia, which further results in acute coronary syndromes. (reportlinker.com)
  • Data indicates that coronary microvascular dysfunction (CMD), due to endothelial and non-endothelial dependent mechanisms, may be an explanation in at least half of these symptomatic women who have evidence of myocardial ischemia. (springer.com)
  • For the study, Arnold and colleagues used the American College of Cardiology's Practice Innovation and Clinical Excellence (PINNACLE) database to identify 38,775 outpatients with a history of myocardial infarction or coronary revascularization. (medpagetoday.com)
  • Stable coronary artery disease refers to a reversible supply/demand mismatch related to ischemia, a history of myocardial infarction, or the presence of plaque documented by catheterization or computed tomography angiography. (aafp.org)
  • In patients who have had a myocardial infarction or revascularization procedure, secondary prevention of coronary artery disease by comprehensive risk factor modification reduces mortality, decreases subsequent cardiac events, and improves quality of life. (aafp.org)
  • The technique may allow for an easier and possibly more accurate identification of patients and coronary stenoses that are likely to benefit from revascularization," Dr. von Spiczak said. (eurekalert.org)
  • Note that the lack of statin treatment was associated with no health insurance whereas factors associated with statin treatment included male sex, coexisting hypertension, and a recent coronary revascularization procedure. (medpagetoday.com)
  • Overall, the CTA result was classified as CAD-RADS 4-V. The patient was referred to Cardiology, and was promptly taken to the lab for invasive coronary angiography (ICA), where a severe right coronary artery stenosis was confirmed (Fig.1B), and revascularization was successfully performed via drug-eluting stent. (massgeneral.org)
  • These stress tests are able to detect the presence of flow-limiting blockages in the coronary arteries, generally in the range of at least a 50% reduction in the diameter of at least one of the three major coronary arteries. (rxlist.com)
  • The dye helps enhance the radiographic image of your coronary arteries to identify any blockages. (healthline.com)
  • The next day, his cardiologist, Dr. Remington, performed a diagnostic cardiac catheterization, which confirmed that Dante had numerous blockages in his coronary arteries. (medtronic.com)
  • Traditionally, the diagnosis of CAD has relied on tests that look for evidence of 'significant' blockages within the coronary arteries . (verywell.com)
  • Here, a surgeon creates a graft using blood vessels from the leg or another part of the body that can be used as a channel to bypass a blocked artery. (news-medical.net)
  • To diagnose coronary artery disease, your doctor will look at markers such as blood pressure, cholesterol profile and blood glucose (from a blood test) as well as your health history and family history, says McEvoy. (hopkinsmedicine.org)
  • Diagnostic tests are used to diagnose coronary artery disease and the most effective treatment method. (clevelandclinic.org)
  • They attract fibrous tissue, blood components, and calcium, and harden into artery-clogging plaques. (encyclopedia.com)
  • This balloon is then inflated, which pushes fatty deposits or plaques against the artery walls. (news-medical.net)
  • This is caused by the build up of fatty deposits called plaques within the endothelial lining of the arteries. (news-medical.net)
  • Sometimes, plaques burst open and cause the blood cells that form clots (called "platelets") to rush into the artery around the plaque. (healthline.com)
  • The approved drugs in the coronary artery disease space target angiotensin converting enzyme, amyloid beta/amyloid plaques, calcium channel, and coagulation factor X. The majority of marketed drugs are administered via the oral route, with one product being available in an intravenous formulation. (reportlinker.com)
  • Using imaging scans (CT angiography), the researchers assessed the amount and types of coronary plaques, before and after reductions in cocaine use. (eurekalert.org)
  • The plaques can also suddenly rupture, causing a blood clot to form acutely within the coronary artery that produces a sudden obstruction of blood flow. (verywell.com)
  • Since calcium deposits generally occur in plaques, measuring the amount of calcium in the arteries yields an indication of whether CAD (and therefore plaques) is present as well as how extensive the CAD may be. (verywell.com)
  • The team went on to measure FAI in 273 additional patients (156 with and 117 without significant coronary plaques) in a clinical setting and who underwent coronary angiography. (medindia.net)
  • CTA demonstrated calcified and noncalcified plaque causing a severe stenosis in the dominant proximal right coronary artery (RCA) (Fig.1A) additional plaques were noted in the left anterior descending and circumflex arteries, but none were deemed greater than 50% diameter narrowing. (massgeneral.org)
  • The purpose of this study is to evaluate the cardiovascular outcomes of alogliptin compared with placebo, in addition to standard of care, in patients with type II diabetes mellitus and acute coronary syndrome. (centerwatch.com)
  • Acute coronary syndrome has a male predominance. (reportlinker.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Circulating vesicles released from platelets, erythrocytes, leukocytes, and endothelial cells contain potential valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease. (nih.gov)
  • Mayo Clinic Q and A: Coronary artery disease -- prevention and early warning signs Nov. 23, 2018, 10:00 p.m. (mayoclinic.org)
  • While further studies are needed, these results emphasize the unique nature of coronary artery disease development in women compared to men, and show that MRI could one day be a useful tool in the prevention and management of the disease in women, especially for those with intermediate risk. (prweb.com)
  • But in view of the fact that the direct cause of sudden death of the disease is thrombotic occlusion of a coronary artery, aspirin might act as the effective means for prevention of sudden death due to Kawasaki disease. (aappublications.org)
  • may have important implications for the prevention of cocaine-induced coronary artery disease," the researchers conclude. (eurekalert.org)
  • The key elements in the prevention of coronary artery disease (CAD) in patients with rheumatoid arthritis (RA) are aggressive management of traditional risk factors and optimization of antiinflammatory and immunomodulatory therapy to achieve effective disease control. (uptodate.com)
  • The only established noninvasive imaging biomarker of predictive value in primary prevention is Coronary calcium scoring (CCS), but it identifies only irreversible changes in the vessel wall that are not altered by interventions to reduce CAD risk, such as statins or lifestyle changes. (medindia.net)
  • Written by the world's foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. (ovid.com)
  • Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer. (healthwise.net)
  • In the United States during the same year, 405,309 people died from coronary artery disease, and more than half the deaths were in men, noted by the Centers for Disease Control and Prevention . (emaxhealth.com)
  • Many risk factors for coronary artery disease can be controlled, helping to prevent or delay the development of CAD. (bidmc.org)
  • Some risk factors for coronary artery disease can be changed and others cannot. (heartandstroke.ca)
  • The current literature indicates that of the major risk factors for coronary artery disease (CAD), United States blacks and whites have similar rates for cigarette smoking and cholesterol levels. (unboundmedicine.com)
  • In turn, proteins, calcium deposits, cholesterol and other substances traveling through your blood vessels begin to stick to the artery walls, combining with fat to form plaque. (bidmc.org)
  • Calcium scans are a form of CT scanning that can quantify a number of calcium deposits in the coronary arteries . (verywell.com)
  • The method was tested on around 500 people, both patients with suspected coronary artery disease and healthy volunteers. (medindia.net)
  • Guthrie Cardiac and Vascular team treats patients with circulatory diseases: abdominal aortic aneurysm, carotid artery disease, and peripheral artery disease. (guthrie.org)
  • Obstructive left main stem coronary disease: is it time to recommend coronary stenting? (bmj.com)
  • While IHD care has focused around detection and treatment of obstructive coronary artery disease (CAD), it is clear that symptomatic patients with evidence of ischemia do not always have obstructive CAD. (springer.com)
  • Ischemia and No Obstructive Coronary Artery Disease (INOCA): developing evidence-based therapies and research agenda for the next decade. (springer.com)
  • Persistent chest pain and no obstructive coronary artery disease. (springer.com)
  • Explain that despite evidence from clinical trials that statins help prevent cardiovascular event, many patients with obstructive coronary artery disease (CAD) are not being treated with statin medications. (medpagetoday.com)
  • ABSORB III - A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions Absorb™ is an investigational bioabsorbable vascular scaffold manufactured by Abbott. (centerwatch.com)
  • This is a non-randomized, multi-center, prospective, single arm, controlled clinical study to collect information about the safety and effectiveness of the COBRA PzFTM Coronary Stent System in the treatment of de novo stenotic lesions in native coronary arteries. (centerwatch.com)
  • Clinical observations have documented substantial differences in the extent of collateralization among patients with coronary artery disease (CAD), with some individuals demonstrating marked abundance and others showing nearly complete absence of these vessels. (ahajournals.org)
  • Clinical investigations suggest that a significant minority of CAD patients present with or develop in the course of their illness extra-arterial conduits, termed coronary collaterals, which link proximal and distal parts of the arterial tree bypassing areas of stenosis and/or occlusion. (ahajournals.org)
  • The majority of industry-sponsored drugs in active clinical development for coronary artery disease are in Phase II. (reportlinker.com)
  • The distribution of clinical trials across Phase I-IV indicates that the majority of trials for coronary artery disease have been in the late phases of development, with 52% of trials in Phase III-IV, and 48% in Phase I-II. (reportlinker.com)
  • The US has a substantial lead in the number of coronary artery disease clinical trials globally. (reportlinker.com)
  • Clinical trial activity in the coronary artery disease space is dominated by completed trials. (reportlinker.com)
  • Pfizer has the highest number of completed clinical trials for coronary artery disease, with 96 trials. (reportlinker.com)
  • Prevalence and predictors of nonobstructive coronary artery disease identified with coronary angiography in contemporary clinical practice. (springer.com)
  • Diamond, G.A., Forester, J.S.: Analysis of probability as an aid in the clinical diagnosis of coronary artery disease. (springer.com)
  • In 1967 Tomisaku Kawasaki reported 50 children with a new clinical disease entity: mucocutaneous lymph node syndrome, 1 later named Kawasaki disease (KD). (aappublications.org)
  • See 'Coronary artery disease in rheumatoid arthritis: Pathogenesis, risk factors, clinical manifestations, and diagnostic implications', section on 'Clinical manifestations' and 'Coronary artery disease in rheumatoid arthritis: Pathogenesis, risk factors, clinical manifestations, and diagnostic implications', section on 'Diagnosis and screening' . (uptodate.com)
  • Efforts have been made to try to quantify the increase in risk in patients with RA, which results from multiple interacting factors (See 'Risk estimation' below and 'Coronary artery disease in rheumatoid arthritis: Pathogenesis, risk factors, clinical manifestations, and diagnostic implications', section on 'Pathogenesis' and 'Coronary artery disease in rheumatoid arthritis: Pathogenesis, risk factors, clinical manifestations, and diagnostic implications', section on 'Risk factors' . (uptodate.com)
  • Cardiovascular Innovations and Applications (CVIA) publishes focused articles and original clinical research that explore novel developments in cardiovascular disease, effective control and rehabilitation in cardiovascular disease, and promote cardiovascular innovations and applications for the betterment of public health globally. (ingentaconnect.com)
  • She used an advanced imaging analysis technique to study movement in the carotid artery using standard clinical ultrasound images. (medindia.net)
  • In sum, careful analysis of family data suggests that the available clinical data are insufficient to make any conclusions and certainly does not support the author's conclusion that the 21-bp deletion does not cosegregate with the disease and does not cause CAD. (jci.org)
  • Cole, J.H. and Sperling, L.S. (2004) Premature coronary artery disease: Clinical risk factors and prognosis. (scirp.org)
  • This may have allowed the team to identify barriers to prescribing for coronary artery disease(5) and to potentially adjust the intervention accordingly. (cmaj.ca)
  • Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. (springer.com)
  • Hasdai D, Holmes DR Jr, Higano ST, Burnett JC Jr, Lerman A. Prevalence of coronary blood flow reserve abnormalities among patients with nonobstructive coronary artery disease and chest pain. (springer.com)
  • Sometimes these stents are laced with slowly eluting medications to prevent inflammation and re-narrowing of the artery. (news-medical.net)
  • Expression of inducible nitric oxide synthase gene in diabetic and non-diabetic coronary artery disease patients," Inflammation . (hindawi.com)
  • Cholesterol-containing deposits (plaque) in the arteries and inflammation are usually to blame for coronary artery disease. (hubpages.com)
  • In addition, reducing cocaine use led to decreased levels of endothelin-1 (ET-1) --an inflammation-promoting protein that plays a key role in the development of coronary artery disease. (eurekalert.org)
  • This preliminary study demonstrates potentially beneficial effects of cocaine abstinence/reduction on inflammation and coronary plaque phenotype," Dr. Lai and coauthors write. (eurekalert.org)
  • While it is unclear how reduced cocaine use leads to regression of coronary artery disease, "Inflammation appears to be a significant link. (eurekalert.org)
  • Perivascular fat attenuation index (FAI) measured by CT imaging can be an effective tool to detect and monitor coronary inflammation and risk of coronary artery disease, according to a recent study published by scientists at University of Oxford. (medindia.net)
  • To overcome the gaps in the existing tools, the research team has developed an imaging technique that measures the size and quantity of the fat surrounding the coronary arteries and calculate the perivascular fat attenuation index (FAI) that occurred in response to coronary inflammation. (medindia.net)
  • On perivascular imaging, higher FAI was found to be associated with greater degree of coronary inflammation (confirmed by FDG uptake on PET). (medindia.net)
  • Presence of coronary inflammation was also confirmed by tissue uptake of 18F-fluorodeoxyglucose in positron emission tomography, which is the gold standard method to noninvasively assess tissue inflammation in vivo. (medindia.net)
  • The fat detects inflammation, becoming more watery and less fatty as it sits next to an inflamed artery," said Charalambos Antoniades, a senior author on the paper at the University of Oxford. (medindia.net)
  • A more recent article on stable coronary artery disease is available. (aafp.org)
  • The implant device is designed to continuously monitor the electrocardiogram signal and detect ST shifts that could be indicative of a blockage of a coronary artery. (centerwatch.com)
  • Recent research indicates that infection from organisms such as chlamydia bacteria may be responsible for some cases of coronary artery disease. (encyclopedia.com)
  • The analyst estimates that in 2017, there were approximately 327.9 million prevalent cases of coronary artery disease worldwide, and forecasts that number to increase to 365.9 million prevalent cases by 2026. (reportlinker.com)
  • It is true that the majority of chronic disease care in Canada (such as management of coronary artery disease) occurs in primary care and that there is room for improvement in how we manage these patients. (cmaj.ca)
  • The reductions in coronary plaque remained significant after adjustment for other cardiovascular risk factors. (eurekalert.org)
  • Plaque is made up of deposits of cholesterol and other substances in the artery. (cdc.gov)
  • This means that fatty deposits called plaque (say "plak") build up inside the arteries. (rexhealth.com)
  • This means that fatty deposits called plaque build up inside the arteries. (rexhealth.com)
  • Coronary artery disease happens when fatty deposits called plaque (say "plak") build up inside your coronary arteries. (healthwise.net)
  • The prevalence of cardiovascular comorbidity is difficult to assess accurately, because cardiovascular disease (CVD) has a tendency to remain silent in the rheumatoid patient. (nih.gov)
  • Coronary artery disease (CAD) is the leading cause of death in the United States, with more than 1 million new and recurrent cardiovascular events occurring each year, and its prevalence and impact are expected to grow. (aafp.org)
  • He had severe coronary artery disease similar to Sergey Grinkov. (wikipedia.org)
  • Lack of association between endothelial nitric oxide synthase gene polymorphisms and risk of premature coronary artery disease in the Greek population," Acta Cardiologica , vol. 63, no. 5, pp. 609-614, 2008. (hindawi.com)
  • Shemirani, H. and Separham, K.H. (2007) The relative impact of smoking or Hypertension on severity of premature coronary artery disease. (scirp.org)
  • Cardiac catheterization checks your arteries for flow and blockage. (familydoctor.org)
  • Coronary Artery Disease29(8):694-695, December 2018. (lww.com)
  • Performing a stress test in conjunction with either a thallium/Cardiolite study or an echocardiogram improves the ability to find partially blocked coronary arteries. (verywell.com)
  • Association of vitamin D deficiency and degree of coronary artery disease in cardiac patients with type 2 diabetes. (greenmedinfo.com)
  • Monitors blockage and flow of blood through the coronary arteries. (cdc.gov)
  • Risk of developing coronary artery disease increases steadily as blood cholesterol levels increase above 160 mg/dL. (encyclopedia.com)
  • The plaque may also rupture, in which case a blood clot may form on its surface and almost completely prevent blood from passing through the artery. (news-medical.net)
  • As a result, blood cells called platelets will try to repair the artery, forming a blood clot. (webmd.com)
  • This is typically because the arteries are damaged, diseased, or blocked, all of which can disrupt the blood flow. (healthline.com)
  • When your arteries narrow, it leaves less space for blood to flow. (healthline.com)
  • Healthy coronary arteries have smooth walls through which blood can easily flow. (healthline.com)
  • Damage to the arteries can be slowed or halted with lifestyle changes, including smoking cessation, dietary modifications, and regular exercise, or by medications to lower blood pressure and cholesterol levels. (healthcentral.com)
  • In a healthy artery, red blood cells flow through unimpeded. (medlineplus.gov)
  • Eventually, the artery may become too narrow for clotted blood to pass through. (medlineplus.gov)
  • As the plaque grows bigger, it limits the amount of blood that can flow through the artery. (healthgrades.com)
  • Reduced blood flow occurs when one or more of these arteries becomes partially or completely blocked. (healthline.com)
  • Arteries are the blood vessels that carry oxygen-rich blood throughout your body. (rexhealth.com)
  • If your blood pressure is above normal, you have a greater risk of developing coronary artery disease. (healthcentral.com)
  • Lowering high blood pressure can also slow the progression of kidney disease. (healthcentral.com)
  • 1 Thus, collateral arteries function as "natural bypasses," effectively restoring blood flow to compromised tissues. (ahajournals.org)
  • It narrows and clogs the arteries, slowing the flow of blood. (heartandstroke.ca)
  • In a large RCT, older adults with no diabetes mellitus who had cardiovascular disease or at least a 15% 10-year risk of cardiovascular events were randomized to a systolic blood pressure target of 120 or 140 mm Hg. (aafp.org)
  • Healthy arteries normally allow blood to flow freely to wherever it needs to go. (northshore.org)
  • Poor diet choices, sedentary lifestyle habits, tobacco use and medical conditions such as diabetes , obesity and high blood pressure (hypertension) can greatly contribute to the narrowing of the arteries, increasing the chance for a life-threatening cardiovascular event. (northshore.org)
  • The surgeon connects, or grafts, a healthy blood vessel from another part of your body to the narrowed coronary artery. (healthlinkbc.ca)
  • The grafted blood vessel goes around (bypasses) the narrowed part of the artery. (healthlinkbc.ca)
  • This can happen in the new blood vessels used in the bypass, as well as in the other arteries. (healthlinkbc.ca)
  • Age - Men who are 45 years of age and older and women who are 55 years of age and older are more likely to have coronary artery disease. (encyclopedia.com)
  • Damage or injury to the inner layer of the coronary arteries caused by the risk factors listed above. (heartandstroke.ca)