Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The veins and arteries of the HEART.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The circulation of blood through the CORONARY VESSELS of the HEART.
Narrowing or constriction of a coronary artery.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The vessels carrying blood away from the heart.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Spasm of the large- or medium-sized coronary arteries.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Pathologic deposition of calcium salts in tissues.
Elements of limited time intervals, contributing to particular results or situations.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
Drugs used to cause dilation of the blood vessels.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The hollow, muscular organ that maintains the circulation of the blood.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Pressure, burning, or numbness in the chest.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
The main artery of the thigh, a continuation of the external iliac artery.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Persistent and reproducible chest discomfort usually precipitated by a physical exertion that dissipates upon cessation of such an activity. The symptoms are manifestations of MYOCARDIAL ISCHEMIA.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The arterial blood vessels supplying the CEREBRUM.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Motion pictures of the passage of contrast medium through blood vessels.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Lesions formed within the walls of ARTERIES.
Radiography of blood vessels after injection of a contrast medium.
A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.
Deposition of calcium into the blood vessel structures. Excessive calcification of the vessels are associated with ATHEROSCLEROTIC PLAQUES formation particularly after MYOCARDIAL INFARCTION (see MONCKEBERG MEDIAL CALCIFIC SCLEROSIS) and chronic kidney diseases which in turn increase VASCULAR STIFFNESS.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
The condition of an anatomical structure's being constricted beyond normal dimensions.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Conditions with excess LIPIDS in the blood.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Substances used to allow enhanced visualization of tissues.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
The nonstriated involuntary muscle tissue of blood vessels.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The transference of a heart from one human or animal to another.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Contractile activity of the MYOCARDIUM.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Diseases that do not exhibit symptoms.
The return of a sign, symptom, or disease after a remission.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Radiography of the heart and great vessels after injection of a contrast medium.
The vein which drains the foot and leg.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The hospital unit in which patients with acute cardiac disorders receive intensive care.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The condition of an anatomical structure's being dilated beyond normal dimensions.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A clinical syndrome characterized by the development of CHEST PAIN at rest with concomitant transient ST segment elevation in the ELECTROCARDIOGRAM, but with preserved exercise capacity.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
The flow of BLOOD through or around an organ or region of the body.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Substances used to lower plasma CHOLESTEROL levels.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Examinations used to diagnose and treat heart conditions.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Obstruction of flow in biological or prosthetic vascular grafts.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
ANGINA PECTORIS or angina-like chest pain with a normal coronary arteriogram and positive EXERCISE TEST. The cause of the syndrome is unknown. While its recognition is of clinical importance, its prognosis is excellent. (Braunwald, Heart Disease, 4th ed, p1346; Jablonski Dictionary of Syndromes & Eponymic Diseases, 2d ed). It is different from METABOLIC SYNDROME X, a syndrome characterized by INSULIN RESISTANCE and HYPERINSULINEMIA, that has increased risk for cardiovascular disease.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Formation and development of a thrombus or blood clot in the blood vessel.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Constitutional, biochemical and lifestyle correlates of fibrinogen and factor VII activity in Polish urban and rural populations. (1/8418)

BACKGROUND: Fibrinogen and factor VII activity are known to be related to atherosclerosis and coronary heart disease, but population differences in clotting factors and modifiable characteristics that influence their levels have not been widely explored. METHODS: This paper examines correlates of plasma fibrinogen concentration and factor VII activity in 2443 men and women aged 35-64 in random samples selected from the residents in two districts in urban Warsaw (618 men and 651 women) and from rural Tarnobrzeg Province (556 men and 618 women) screened in 1987-1988, and assesses which characteristics might explain urban-rural differences. Fibrinogen and factor VII activity were determined using coagulation methods. RESULTS: Fibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw. Factor VII activity was higher in Warsaw (9.2% in men and 15.3% in women). After adjustment for selected characteristics, fibrinogen was higher in smokers compared to non-smokers by 28 mg/dl in men and 22 mg/dl in women. In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P < 0.01). After adjustment for other variables, a higher factor VII activity in Warsaw remained significant (a difference of 9.4% in men and 14.8% in women). Lower fibrinogen in Warsaw remained significant only in women (15.4 mg/dl difference). CONCLUSIONS: The study confirmed that sex, age, BMI, smoking and blood lipids are related to clotting factors. However, with the exception of gender differences and smoking, associations between clotting factors and other variables were small and of questionable practical importance.  (+info)

Combined carotid endarterectomy and coronary artery bypass graft. (2/8418)

Atherosclerosis is a generalized disease which afflicts a considerable number of patients in both the carotid and coronary arteries. Although the risk of stroke or death use to combined carotid endarterectomy (CEA) and coronary artery bypass graft (CABG) is thought to be higher than that of each individual operation, the combined procedure is generally preferred over staged operations to treat such patients. We performed the combined procedure safely with the aid of intraoperative portable digital subtraction angiography (DSA). This report describes our experience with the operative strategy of simultaneous CEA and CABG. Ninety CEA and 404 CABG were carried out between January 1989 and December 1997. A total of six patients received the combined procedure with the aid of intraoperative DSA; they were studied retrospectively. Postoperative mortality and morbidity after the combined procedure was 0%. In the combined procedure, neurological complications are difficult to detect after CEA because the patient must be maintained under general anesthesia and extracorporeal circulation during the subsequent CABG. However, intraoperative DSA can confirm patency of the internal carotid artery and absence of flap formation after CEA, and the CABG can be performed safely. Intraoperative portable DSA between CEA and CABG is helpful in preventing perioperative stroke in the combined procedure.  (+info)

Macroscopic distribution of coronary atherosclerotic lesions in cholesterol-fed rabbits. (3/8418)

In the present study we macroscopically examined a change in the distribution of coronary atherosclerosis in cholesterol-fed rabbits. Rabbits were fed a cholesterol-enriched diet for 15 weeks, then replaced by a normal diet, and were sacrificed at 15, 24, 32 and 42 weeks after the start of the experiment. The coronary atherosclerosis in the cholesterol-fed rabbits was distributed more densely in the proximal portion than in the middle and distal portions, and the lesions were severe at 24 and 32 weeks after the start of the experiment. comparison of lesions in the three portions at these time points showed that the percentages of lesion areas in the proximal portion, the middle portion and the distal portion were approximately 51%, 21 to 25% and 0.2 to 3.7%, respectively. Macroscopic observation of the coronary atherosclerotic lesions showed that the lesions formed over the vessel lumen in the proximal portion within the range of approximately 5 mm from the orifice of the left coronary artery. In the middle portion, the lesions formed predominantly around the orifices of branches as small patchy lesions from 1 to 3 mm in diameter. These findings support previous histopathological reports that suggested that the incidence of stenosis in the proximal portion was high, and the incidence of lesion occurrence in the middle and the distal portions varied. The method, macroscopical investigation of the coronary artery, is useful for analyzing coronary atherosclerosis in the rabbit.  (+info)

Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. (4/8418)

To investigate the pathogenesis of hyperlipidemia-induced atherosclerosis, we examined age-dependent changes in platelet activity, blood coagulation and fibrinolysis in susceptibility to a high cholesterol diet (HCD) feeding in male ICR mice. Pretreatment of platelet-rich-plasma from HCD feeding mice for 3 days with epinephrine (300 microM) resulted in a marked enhancement of adenosine 5'-diphosphate (ADP: 0.1 microM) or collagen (0.7 microgram/ml)-stimulated aggregation compared with the same in control mice. Yohimbine as alpha 2-adrenergic blocker antagonized these aggregations in a dose-dependent manner. A significant increase in plasma total cholesterol and VLDL (very low-density lipoprotein)-LDL (low-density lipoprotein)-cholesterol and the liver/body weight ratio was observed in mice fed on HCD for 3 months (3-month HCD mice). In the early phase of this experiment, a significant increase in fibrinogen was observed. In the middle phase, increases in the activity of antithrombin III (ATIII) and alpha 2-plasmin inhibitor (alpha 2-Pl) followed. Plasminogen content gradually decreased in both normal diet and HCD mice throughout the experiment. The activity of plasminogen activator inhibitor (PAI) decreased in 3-month HCD mice. Morphological observation of the aortic arch from 3-month HCD mice revealed apparent atheromatous plaques not seen in control mice. These results suggest that 3-month HCD mice can be a convenient hyperlipidemia-induced atherosclerotic model and the changes in platelet activity, coagulation and fibrinolysis in the early phase may be a cause of pathologic changes in this model.  (+info)

2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: role of glycoxidation and lipoxidation reactions in vascular tissue damage. (5/8418)

We have pursued the hypothesis that the carbonyl modification of proteins by glycoxidation and lipoxidation reactions plays a role in atherogenesis. Human atherosclerotic tissues with fatty streaks and uremic arteriosclerotic tissues were examined, with specific antibodies, to detect protein adducts formed with carbonyl compounds by glycoxidation or lipoxidation reactions, i.e. advanced glycation end products (AGEs) or glycoxidation products, such as carboxymethyllysine (CML) and pentosidine, and lipoxidation products, such as malondialdehyde (MDA)-lysine and 4-hydroxy-nonenal (HNE)-protein adduct. All the four adducts were identified in the proliferative intima and in macrophage-rich fatty streaks. If the carbonyl modification is not a mere result but is a contributor to atherogenesis, inhibition of glycoxidation and lipoxidation reactions might prevent vascular tissue damage. We tested this hypothesis in rats following balloon injury of their carotid arteries, a model exhibiting a remarkable intimal thickening, which are stained positive for all the four adducts. Oral administration of 2-isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanili de (OPB-9195), an inhibitor of both glycoxidation and lipoxidation reactions, in rats following balloon injury effectively prevented the intimal thickening. These data suggest a role for the carbonyl modification of proteins by glycoxidation and lipoxidation reactions in most, if not all, types of vascular tissue damage ('carbonyl stress'), and the usefulness of inhibitors of carbonyl reactions for the treatment of vascular tissue damage.  (+info)

Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. (6/8418)

BACKGROUND: Elevated blood concentrations of total homocysteine (tHcy) have been implicated in the pathogenesis of atherosclerotic cardiovascular disease. Previous studies identified suboptimal nutritional status and dietary intake of folate, vitamin B-6, and vitamin B-12 as determinants of elevated tHcy. OBJECTIVE: We identified other nutritional factors associated with tHcy in 260 retired schoolteachers in the Baltimore metropolitan area. DESIGN: We performed observational analyses of baseline and 2-4-mo follow-up data collected in a study designed to test the feasibility of conducting a large-scale clinical trial of vitamin supplements by mail. The study population consisted of 151 women and 109 men with a median age of 64 y. At baseline, each participant completed a food-frequency questionnaire. At follow-up, fasting serum tHcy was measured. RESULTS: In multivariable linear regression and generalized linear models, there was an independent, inverse dose-response relation between dietary protein and In tHcy (P = 0.002) and a positive, significant dose-response relation between coffee consumption and In tHcy (P for trend = 0.01). Other significant predictors of In tHcy were creatinine (positive; P = 0.0001) and prestudy use of supplemental B vitamins (inverse; P = 0.03). In stratified analyses restricted to persons receiving standard multivitamin therapy, the association of 1n tHcy with dietary protein and coffee persisted. CONCLUSIONS: These results support the hypothesis that increased protein intake and decreased coffee consumption may reduce tHcy and potentially prevent atherosclerotic cardiovascular disease and other disease outcomes.  (+info)

Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque. (7/8418)

BACKGROUND: Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human coronary atherosclerotic plaques. METHODS AND RESULTS: Immunohistochemical staining and in situ hybridization demonstrated minimal and random expression of TN-C in fibrotic but lipid-poor atherosclerotic plaques. In contrast, all plaques with an organized lipid core or ruptured intimal surface strongly expressed TN-C, which was preferentially concentrated around the lipid core, shoulder regions, and ruptured area of the plaques but not in the fibrous cap. TN-C was not detected in normal arterial tissue. To identify the cellular source of TN-C, the plaques were stained with smooth muscle cell- and macrophage-specific antibodies. TN-C expression correlated with the infiltration of macrophages. Northern blot and immunoprecipitation analysis showed that macrophages expressed 7. 0-kb TN-C mRNA and 220-kDa protein. Reverse transcription-polymerase chain reaction of total RNA derived from macrophages showed that they express the small isoform of TN-C. Zymogram analysis revealed that macrophages markedly increased MMP-9 expression. CONCLUSIONS: This study demonstrates that the level of TN-C expression correlates with the degree of inflammation present, not with plaque size. In addition, cultured macrophages have the capacity to express the TN-C gene. These findings suggest the significance of macrophages in the remodeling of atherosclerotic plaque matrix composition.  (+info)

Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty. (8/8418)

BACKGROUND: Restenosis is a common problem after all revascularization procedures in atherosclerotic coronary arteries. Reactivated human cytomegalovirus (CMV) has been detected in tissues of restenotic vascular lesions and was hypothesized to be a contributing pathogenic factor. Recent data suggest an association of restenosis after optimal coronary atherectomy with CMV serostatus, and a possible role of antiviral therapy was discussed. We therefore tested the hypothesis that prior CMV infection might be a risk factor for restenosis after conventional coronary balloon angioplasty (PTCA). METHODS AND RESULTS: We analyzed 92 consecutive patients who had been admitted for control angiography after previous PTCA within a mean interval of 6 months. Anti-CMV antibodies were measured as an indicator of prior CMV infection and latency. The coronary angiograms before PTCA, directly after, and 6 months later were analyzed quantitatively. Sixty-five percent of the patients were CMV-positive. Before PTCA, the degree (mean+/-SD) of stenosis was 69+/-10% in CMV-positive and 68+/-8.3% in CMV-negative subjects. PTCA resulted in a residual stenosis of 39% in both groups. After 6 months, the late losses of luminal diameter in the CMV-positive and -negative groups were 11+/-13% and 12+/-15%, respectively (P=0.658). In an ANCOVA with 25 potential risk factors for restenosis, CMV serostatus was not significantly associated with restenosis development. CONCLUSIONS: Our data indicate that prior CMV infection, in contrast to optimal atherectomy, is not associated with chronic restenosis after conventional coronary balloon angioplasty. The results do not support a possible benefit from antiviral therapy.  (+info)

Background: Coronary artery disease is sometimes associated with chronic conduction block. Our aim is to correlate between chronic conduction block and coronary artery disease. We performed ECG and coronary angiography of all patients who were admitted for permanent pacemaker implantation to find correlation between them. Methods: Coronary angiography was performed in all 160 patients of chronic conduction block during twenty four months of study period who were admitted for pacemaker implantation. We compared the coronary artery disease in different types of conduction block. Results: Among the study population 35(22%) patients are of single vessel coronary artery disease (CAD),13 (8%) patients had double vessel coronary artery disease, 6 (4%) patients had triple vessel coronary artery disease, 2 (1%) patients had left main disease and 104 (65%) patients had normal or insignificant coronary anatomy. Conclusion: Coronary artery disease is quite common in chronic conduction disorder. So there ...
Table of Contents. Table of Contents 2. List of Tables 8. List of Figures 9. Introduction 10. Global Markets Direct Report Coverage 10. Coronary Artery Disease (CAD) (Ischemic Heart Disease) Overview 11. Therapeutics Development 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Overview 12. Pipeline Products for Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Comparative Analysis 13. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Development by Companies 14. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Therapeutics under Investigation by Universities/Institutes 17. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Pipeline Products Glance 18. Late Stage Products 18. Clinical Stage Products 19. Early Stage Products 20. Unknown Stage Products 21. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under Development by Companies 22. Coronary Artery Disease (CAD) (Ischemic Heart Disease)-Products under ...
Vasc Health Risk Manag. 2014 Jan 21;10:55-62. doi: 10.2147/VHRM.S53557. eCollection 2014.. Roed T1, Kristoffersen US2, Knudsen A3, Wiinberg N4, Lebech AM1, Almdal T5, Thomsen RW6, Kjær A2, Weis N7.. Abstract. OBJECTIVE: Chronic hepatitis C is a global health problem and has been associated with coronary artery disease. Our aim was to examine the prevalence of coronary artery disease risk markers including endothelial biomarkers in patients with chronic hepatitis C and matched comparisons without manifest cardiovascular disease or diabetes in a cross-sectional design.. METHODS: Sixty patients with chronic hepatitis C (mean age 51 years) were recruited from the Department of Infectious Diseases at Copenhagen University Hospital, and compared with 60 age-matched non-hepatitis C virus-infected individuals from a general population survey. We examined traditional coronary artery disease risk factors, metabolic syndrome, carotid intima media thickness, and a range of endothelial biomarkers.. RESULTS: ...
Objectives: Higher coronary atherosclerotic burden has been associated with increased cardiovascular events including mortality. The SYNTAX score (SXs) reflects coronary atherosclerotic burden. Given the body of evidence implicating inflammation in atherosclerotic process, we hypothesized that procalcitonin (PCT) as an inflammatory marker may be related to coronary atherosclerotic burden. Thus, we aimed to investigate the relationship between serum PCT levels and SXs in patients with stable CAD. ...
TY - JOUR. T1 - Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease. AU - Egashira, Kcnsuke. AU - Kikuchi, Yutaka. AU - Sagara, Tomohiko. AU - Sugihara, Masayoshi. AU - Nakamura, Motoomi. PY - 1987/1/1. Y1 - 1987/1/1. N2 - Long-term prognosis of 90 patients with vasospastic angina without significant coronary artery disease (less than 50% reduction in luminal diameter) was examined for a mean follow-up period of 4 years. All patients had episodes of angina at rest and were treated with calcium antagonists. One patient developed myocardial infarction and 2 died suddenly during the follow-up period. In the patient with myocardial infarction, there was an abrupt worsening of angina prior to the infarction despite therapy with a calcium antagonist. One of the sudden death patients discontinued his calcium antagonist before his death. Of the sudden death patients, one had ventricular tachycardia and the other had a complete atrioventricular block ...
Coronary artery disease is a condition in which the coronary arteries are narrowed by deposits called plaques.. The coronary arteries originate from the aorta and supply blood and oxygen to your heart muscle allowing it pump blood to the body. Normal coronary arteries allow blood to flow freely. However, these arteries can become narrowed by inflammatory fatty deposits called plaques. This disease process is called atherosclerosis. Atherosclerosis that occurs in the coronary arteries is called coronary artery disease.. These plaques build up over time and can decrease the amount of oxygen reaching your heart. Mild coronary artery disease may develop over decades without any symptoms. More severe coronary artery disease can cause chest pain, called angina, and shortness of breath.. If a plaque suddenly ruptures, a blood clot can form and block the hearts blood supply. This is called a heart attack and it can cause permanent damage to the heart. Over time, severe coronary artery disease can also ...
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was
TY - JOUR. T1 - Metabolic syndrome and angiographic coronary artery disease prevalence in association with the framingham risk score. AU - Konstantinou, Dimitris M.. AU - Chatzizisis, Yiannis S.. AU - Louridas, George E.. AU - Giannoglou, George D.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Background: The association of metabolic syndrome with coronary artery disease (CAD) has been studied extensively. However, little is known about the effect of Framingham risk score (FRS) and metabolic syndrome components on the association of metabolic syndrome with angiographically significant CAD. Our aim was to investigate whether that relationship is influenced by individuals 10-year CAD risk profile as assessed by FRS. Furthermore, we sought to elucidate whether metabolic syndrome is associated with angiographically significant CAD independently of its individual components. Methods: We studied a consecutive sample of 150 patients undergoing coronary angiography for the evaluation of chest pain. Metabolic ...
Coronary artery disease is among the most common causes of disability and death. Often, by the time symptoms occur, the process may already be far advanced. Frequently,t he first symptom of coronary artery disease is heart attack and sudden death. Dangerous coronary artery disease may be present in individuals that are totally asymptomatic. A recent study showed that a family history of early-onset coronary artery disease (CAD) is associated with significant amounts of plaque in the coronary arteries apparently healthy patients.. Researchers demonstrated a significant amount of plaque present (coronary plaque burden) in apparently healthy middle-aged close relatives of individuals with early-onset of coronary artery disease. This study underscores the fact that asymptomatic patients may benefit from early cardiac screening and that is especially true for individuals with a family history of early-onset CAD may benefit from screening for subclinical atherosclerosis.. The Cardiac portion of the ...
OBJECTIVES: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD. BACKGROUND: Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability. METHODS: We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects. RESULTS: We first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n
TY - JOUR. T1 - Internal pudendal artery stenoses and erectile dysfunction. T2 - Correlation with angiographic coronary artery disease. AU - Rogers, Jason H. AU - Karimi, Houshang. AU - Kao, John. AU - Link, Daniel P. AU - Javidan, Javid. AU - Yamasaki, Dwayne S.. AU - Dolan, Mark. AU - Laird, John R.. AU - Low, Reginald. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Objectives: To describe the angiographic characteristics of pelvic arterial disease in patients with erectile dysfunction (ED) nonresponsive to phosphodiesterase-5 inhibitors (PDE5i) and suspected coronary artery disease (CAD). Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries. Methods: Ten patients undergoing cardiac catheterization with ED and a history of unsatisfactory response to a PDE5i were studied. ED severity was quantified using the International Index of ED scoring system. We performed angiography ...
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Archbold Hosts Health Talk on Coronary Artery Disease Wednesday, February 11, 2015 Coronary artery disease, also known as coronary heart disease...
Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45-79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex and enrollment time. PON1-activity was similar in cases and controls (60.7 +/- 645.3 versus 62.6 +/- 645.8 U/L, p = 0.3) and correlated with HDL-cholesterol levels (r = 0.16, p , 0.0001). The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict ...
The Coronary Artery Disease Treatment Devices market is expected to grow from USD X.X million in 2020 to USD X.X million by 2026, at a CAGR of X.X% during the forecast period. The global Coronary Artery Disease Treatment Devices market report is a comprehensive research that focuses on the overall consumption structure, development trends, sales models and sales of top countries in the global Coronary Artery Disease Treatment Devices market. The report focuses on well-known providers in the global Coronary Artery Disease Treatment Devices industry, market segments, competition, and the macro environment. Under COVID-19 Outbreak, how the Coronary Artery Disease Treatment Devices Industry will develop is also analyzed in detail in Chapter 1.7 of the report. In Chapter 2.4, we analyzed industry trends in the context of COVID-19. In Chapter 3.5, we analyzed the impact of COVID-19 on the product industry chain based on the upstream and downstream markets. In Chapters 6 to 10 of the
Definition of coronary artery disease in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is coronary artery disease? Meaning of coronary artery disease as a finance term. What does coronary artery disease mean in finance?
TY - JOUR. T1 - Cardiocirculatory effects of beta-adrenergic blockade in coronary artery disease at rest and during upright exercise. T2 - comparison of acebutolol and propranolol. AU - Kaku, R.. AU - Lee, G.. AU - Amsterdam, Ezra A. PY - 1978. Y1 - 1978. UR - UR - M3 - Article. AN - SCOPUS:0017812111. VL - 26. JO - Journal of Investigative Medicine. JF - Journal of Investigative Medicine. SN - 1081-5589. IS - 2. ER - ...
The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography. Fasting vaspin concentrations were compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. We did not find significant difference in vaspin level between target group and controls. Unless the pre-test probability was taken into account, we did not find vaspin difference in the target group, when dividing patients on the basis of
Chaikriangkrai, K.; Palamaner Subash Shantha, G.; Jhun, H.Yeon.; Ungprasert, P.; Sigurdsson, G.; Nabi, F.; Mahmarian, J.J.; Chang, S.Min., 2016: Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
TY - JOUR. T1 - Algorithm to predict triple-vessel/left main coronary artery disease in patients without myocardial infarction. T2 - An international cross validation. AU - Detrano, Robert. AU - Jánosi, A.. AU - Steinbrunn, Walter. AU - Pfisterer, Matthias. AU - Schmid, Johann Jakob. AU - Maggie Meyer, M.. AU - Guppy, Kern H.. AU - Abi-Mansour, Pierre. PY - 1991. Y1 - 1991. N2 - Logistic regression was applied to the clinical, risk factor, and exercise data of consecutive angiographic referrals without prior myocardial infarction to determine an algorithm predicting the probability of triple-vessel/left main coronary artery disease. These data were obtained from a total of 1,074 such subjects from patient populations at four centers (Cleveland Clinic Foundation, Cleveland, Ohio; Hungarian Institute of Cardiology, Budapest, Hungary; the university hospitals, Zurich and Basel, Switzerland; and the Veterans Administration Medical Center, Long Beach, Calif.) and used to derive four separate ...
Treatment options for patients with left main coronary artery disease.. Rev Cardiovasc Med. 2011;12(2):e77-83. Authors: Lee MS, Nguyen J. Coronary artery bypass grafting (CABG) is the gold standard for the treatment of left main disease, whereas percutaneous coronary intervention is a viable option for patients who are candidates for revascularization but ineligible for CABG. CABG is limited by extended hospital stay followed by rehabilitation and mediocre long-term patency of saphenous vein grafts. Drug-eluting stents decrease the restenosis rates compared with bare metal stents and provide comparable clinical outcomes with those of CABG. Patients with isolated left main disease limited to the ostium or midbody are most likely to have good clinical outcomes with low restenosis and stent thrombosis rates. The results of the ongoing EXCEL trial, which compares left main percutaneous coronary intervention with drug-eluting stents and CABG, will provide insight regarding the ideal revascularization ...
Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
TY - JOUR. T1 - ACR appropriateness criteria chronic chest pain - Low to intermediate probability of coronary artery disease. AU - Woodard, Pamela K.. AU - White, Richard D.. AU - Abbara, Suhny. AU - Araoz, Philip A.. AU - Cury, Ricardo C.. AU - Dorbala, Sharmila. AU - Earls, James P.. AU - Hoffmann, Udo. AU - Hsu, Joe Y.. AU - Jacobs, Jill E.. AU - Javidan-Nejad, Cylen. AU - Krishnamurthy, Rajesh. AU - Mammen, Leena. AU - Martin, Edward T.. AU - Ryan, Thomas. AU - Shah, Amar B.. AU - Steiner, Robert M.. AU - Vogel-Claussen, Jens. AU - White, Charles S.. PY - 2013. Y1 - 2013. N2 - Chronic chest pain can arise from a variety of etiologies. However, of those potential causes, the most life-threatening include cardiac disease. Chronic cardiac chest pain may be caused either by ischemia or atherosclerotic coronary artery disease or by other cardiac-related etiologies, such as pericardial disease. To consider in patients, especially those who are at low risk for coronary artery disease, are ...
The global Coronary Artery Disease Therapeutics Market report offers precise analytical information about the Coronary Artery Disease Therapeutics market. The market experts and proficient analysts generate the information based on the past and current situation of Coronary Artery Disease Therapeutics market, various factors affecting the growth trajectory, global sales, demand, total revenue generated, and capitalization of the market. Moreover, the report delivers a summarized assessment of the impact of federal policies and regulations on market operations. It also comprises detailed information pertaining to the Coronary Artery Disease Therapeutics markets current dynamics. The global Coronary Artery Disease Therapeutics market acts as a huge platform that offers several opportunities for many reputed firms, organizations, manufacturers, vendors, and suppliers AstraZeneca, Gilead, Novartis, Pfizer, Bayer, Bristol-Myers Squibb, GlaxoSmithKline, Merck, Mylan, Teva Pharmaceutical Industries ...
Title: Surgical or Interventional Revascularization in Diabetic Patients with Coronary Artery Disease?. VOLUME: 6 ISSUE: 6. Author(s):E. Apostolakis, I. Koniari, D. Velissaris and Efstratios N. Koletsis. Affiliation:Department of Cardiothoracic Surgery, Department of Anaesthesiology and ICU, University of Patras, Patras, Greece.. Keywords:Coronary artery disease, Diabetes mellitus, Coronary artery bypass grafting, Percutaneous transluminal coronary angioplasty, Myocardial infarction, Revascularization, percutaneous transluminal, Surgical revascularization, prothrombotic situation, lipoproteins, manifestations, triglyceride-rich, triggering mechanisms, Plaque-angiogenesis, catabolism, CABG surgery, Abciximab, ischemia, SPECT, AWESOME, worsening symptoms, BASKET-LATE, MACE, perioperatively. Abstract: The combination of diabetes mellitus and coronary artery disease (CAD) constitutes an aggressive disease characterized biologically by chronic inflammatory, proliferative and pro-thrombotic situation. ...
This stock medical exhibit depicts coronary artery disease. The first image shows the normal anatomy of the heart and coronary arteries. The remaining images show cross-sectional views of the arteries. The first has a normal, open lumen. The remaining three have various degrees of stenosis/thrombosis.
OBJECTIVE: Increased levels of lipoprotein(a) are a highly heritable risk factor for coronary artery disease (CAD). The genetic determinants of lipoprotein(a) levels are mainly because of genetic variation in the apolipoprotein(a) gene (LPA). We have tested the association of a relatively common null allele of LPA with lipoprotein(a) levels and CAD risk in a large case-control cohort. We have also examined how null allele genotyping complements apolipoprotein(a) isoform typing to refine the relationship between LPA isoform size and circulating lipoprotein(a) levels. APPROACH AND RESULTS: The LPA null allele (rs41272114) was genotyped in the PROCARDIS (Precocious Coronary Artery Disease) case-control cohort (4073 CAD cases and 4225 controls). Lipoprotein(a) levels were measured in 909 CAD cases and 922 controls; apolipoprotein(a) isoform size was estimated using sodium dodecyl sulfate-agarose gel electrophoresis and a high-throughput quantitative polymerase chain reaction-based method. Null carriers are
Abstract:. Background: Type 2 diabetes mellitus is often associated with severe Coronary artery disease (CAD). Since patients with higher risk of severe disease are likely to get better benefit from aggressive management, it is essential to identify factors which are associated with severe macrovascular disease. We looked at the possibility of hyperinsulinemia being a marker for severe and complex coronary artery disease in type 2 diabetes mellitus, to select patients who would benefit from aggressive treatment. Methods: A cross sectional study of 290 type 2 diabetic patients, who underwent coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited. Biochemical and anthropometric parameters were analysed. Insulin resistance was measured by homeostasis model assessment method. Angiographically measured syntax score of more than 22 is considered to be severe and complex CAD. Receiver operating curve characteristic was performed to find out the ...
Abstract:. Background: Non-communicable diseases constitute about 68% of global death annually. Among NCD deaths, cardiovascular diseases (CVD) ranks first with a share of 46.2% amounting to 17.5 million deaths. First degree relatives of patients with coronary heart disease have a higher risk of getting cardiovascular events due to interplay between genetic as well as environmental factors. The aim of this research WAS to assess the prevalence of Cardiovascular Disease (CVD) risk factors and to estimate the cardiovascular risk among first degree relatives of CAD patients. Methodology: A cross-sectional study was performed in first degree relatives of coronary artery disease patients in cardiology ward of JIPMER a tertiary care hospital in Puducherry. Overall 218 first degree relatives aged ≥18 were involved in study. The desired information was obtained using a pre-tested questionnaire and participants were also subjected to anthropometric measurements and laboratory investigations. WHO/ISH ...
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Background. Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups.. Methods. In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved. The Gensini score (an indicator of CAD severity) was calculated for all, and the risk factors and severity of CAD were compared between the ethnical groups, using adjusted standardized residuals, Kruskal-Wallis test, and multivariable regression analysis.. Results. The mean age of the participants (14,131 [70.1%] men and 6034 [29.9%] women) was 60.7 ± 10.8 years. The Fars (8.7%) and Gilak (8.6%) ethnic groups had the highest prevalence of ≥4 simultaneous risk factors. The mean Gensini score was the ...
Coronary arteries supply oxygen-rich blood to the heart muscle. Coronary artery disease results from atherosclerosis, a buildup of fatty deposits and plaque in the lining of a coronary artery, which narrows the artery and causes a decrease in blood flow to the heart muscle.. When a coronary artery suddenly becomes blocked and blood flow to an area of heart muscle stops, it is called a heart attack. A heart attack can permanently damage heart muscle and cause the affected area of the heart not to pump properly.. Common symptoms of coronary artery disease include shortness of breath and angina (pain or a feeling of increased pressure in the chest). Less common symptoms include nausea, sweating, fatigue, dizziness and decreased exercise tolerance.. In addition to diet, exercise, medication therapy and coronary artery bypass graft (CABG) surgery there are a number of minimally invasive procedures that can restore blood flow through a blocked coronary artery. These procedures include:. ...
Ling Jun Chen, Mercer University College of Pharmacy Coronary artery disease leads to the narrowing of coronary arteries and is associated with risk factors that include cigarette smoking, hypertension, hyperlipidemia, and diabetes. [1] European and U.S. guidelines have declared that patients with coronary artery disease have an increased risk of developing ischemia and infarction. Coronary-artery…
Polymorphisms in paraoxonase 1 (PON1) coding for PON1 enzyme have been studied as genetic markers of coronary artery disease (CAD). PON1 Q192R and PON1 L55M polymorphisms have been analyzed extensively, but data on association and role of these polymorphisms in the etiology of CAD are conflicting. In this study, we tested the genetic association between PON1 Q192R and PON1 L55M polymorphisms and CAD among north Indians. MATERIALS AND METHODS: Two hundred eighty-five angiographically proven patients with coronary artery disease and 200 sex-matched and ethnically matched controls were genotyped for 2 PON1 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Genotype/ allele frequencies were compared in patients and controls using the chi-square test. RESULTS: At PON1-192 locus, there were significant differences between patients and controls (P, 0.05), leading to significant odds ratios for RR genotype (OR= 1.92, CI: 1.19-3.10) and *R allele ...
Motlagh B, ODonnell M, Yusuf S. Prevalence of cardiovascular risk factors in the Middle East: a systematic review. Eur J Cardiovasc Prev Rehabilm2009;16(3):268-80. Cole JH, Sperling LS. Premature coronary artery disease:clinical risk factors and prognosis. Curr Atheroscler Rep2004;6(2):121-5. Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalized anxiety disorder: a 10-year follow-up. Br J Psychiatry 2012;200(4):324-9. Martens EJ, de Jonge P, Na B, et al. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Arch Gen Psychiatry 2010;67(7):750-8. Huffman JC, Smith FA, Blais MA, et al. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res 2008;65(6):557-63. Kawachi I, Sparrow D, Vokonas PS, et al. Symptoms of anxiety and risk of coronary heart disease. The NormativeAging Study. Circulation ...
TY - JOUR. T1 - Usefulness of myocardial perfusion echocardiography to identify obstructive coronary artery disease in patients with abnormal ventricular septal motion. AU - Spevack, Daniel M.. AU - Shoyeb, Abu. AU - Yoon, Andrew J.. AU - Gordon, Garet M.. AU - Matros, Todd. AU - Reynolds, Harmony A.. AU - Shah, Alan. AU - Tunick, Paul A.. AU - Kronzon, Itzhak. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Twenty-three patients who had septal wall motion abnormalities and who underwent angiography within 2 weeks were evaluated by myocardial perfusion echocardiography. Mean perfusion score (plateau video intensity times the wash-in rate) was lower in segments that were supplied by obstructed coronary arteries in real time (7.5 vs 22.6 dB/s, p ,0.005) and with end-systolic triggering (8.6 vs 20.9 dB/s, p ,0.001). Lower mean septal perfusion scores (,12 dB/s) were seen in 14 of 16 patients who had obstructive septal coronary artery disease, and normal mean septal perfusion scores were seen in 6 of 7 patients ...
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
Insulin-resistance is associated with cardiovascular disease but it is not used as a marker for disease in clinical practice. To study the association between the homeostatic model assessment (HOMA-IR) and triglyceride/HDLc ratio (TG/HDLc) with the presence of coronary artery disease in patients submitted to cardiac catheterization. In a cross-sectional study, 131 patients (57.0 ± 10 years-old, 51.5% men) underwent clinical, laboratory and angiographic evaluation and were classified as No CAD (absence of coronary artery disease) or CAD (stenosis of more than 30% in at least one major coronary artery). Prevalence of coronary artery disease was 56.7%. HOMA-IR and TG/HDLc index were higher in the CAD vs No CAD group, respectively: HOMA-IR: 3.19 (1.70-5.62) vs. 2.33 (1.44-4.06), p = 0.015 and TG/HDLc: 3.20 (2.38-5.59) vs. 2.80 (1.98-4.59) p = 0.045) - median (p25-75). After a ROC curve analysis, cut-off values were selected based on the best positive predictive value for each variable: HOMA-IR = 6.0, TG
To evaluate the effectiveness of the graded exercise test in predicting the extent of coronary artery disease and the degree of left ventricular dysfunction in patients with prior myocardial infarction, 100 consecutive patients underwent both graded exercise testing and coronary and left ventricular angiography at a median of 4 months after infarction. The studies caused no complications. An equal number of patients had anterior and inferior infarction. Coronary artery disease, defined as 70 percent or greater stenosis of luminal diameter, was present in three vessels in 31 patients, in two vessels in 35 patients, in one vessel in 33 patients and in no vessel in one patient. With diagnostic electrocardiographic criteria of 1 mm or greater J point depression plus a flat or downsloping S-T segment, 31 patients had an electrocardiographically positive exercise test; 27 of these (87 percent) had two or three vessel coronary artery disease. Of the 21 patients with a negative exercise test, 62 ...
Coronary calcium score is an independent predictor of risk of significant coronary artery disease. It may refine overall risk of coronary artery disease estimated with conventional risk factors. It is based on CT examination and calculation of the Agatston score from the images.
Medical Management Of Stable Coronary Artery Disease ,Stable Coronary Artery Disease (Management patients with stable known or suspected
In this 2-center study of 2,583 consecutive patients without prior known CAD and without obstructive CAD, nonobstructive coronary artery plaque presence and extent as identified by 64-detector row CCTA are associated with heightened mortality risk in a 3-year follow-up period. The CCTA nonobstructive plaque assessment added significant risk prediction beyond patient demographic data, traditional CAD risk factors, and Framingham risk score.. The results of the present study suggest a potential utility for diagnosis of nonobstructive CAD by CCTA. Such patients experience heightened mortality risk, even though they represent a patient population for whom functional stress testing would be expected to be negative and who might not be referred for evaluation by invasive coronary angiography (ICA) after CCTA. Our results confirm prior observations of a high negative predictive value of a normal CCTA for later adverse clinical events but are additive to the prior published reports by identifying a ...
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment of coronary artery disease. We used combined PET and CT to identify ruptured and
TY - CONF AU - Kotur-Stevuljević, Jelena AU - Vemić, Sava AU - Spasojević-Kalimanovska, Vesna AU - Spasić, S. AU - Jelić-Ivanović, Zorana PY - 2009 UR - PB - Taylor & Francis Ltd, Abingdon C3 - Free Radical Research T1 - Association of prooxidative-antioxidative balance (PAB) with inflammation markers in coronary artery disease patients VL - 43 SP - 96 EP - 97 ER ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Change in R wave amplitude (mean delta R) was measured sequentially during and after 12 lead maximal treadmill exercise tests in 14 subjects with normal coronary arteries and 62 patients with coronary artery disease. In normal subjects mean delta R decreased maximally one minute after exercise and returned to control levels within three minutes. In contrast, mean delta R increased in patients with coronary artery disease, the greatest change occurring in patients with either triple vessel or left main disease or those with an akinetic region on the left ventriculogram. R wave amplitude returned to resting levels in five minutes. Increase in R wave amplitude was not directly related to changes in the ST segment. Changes in R wave amplitude during maximal treadmill exercise may improve the discrimination between patients with and without coronary artery disease and may help to identify those patients with abnormal left ventricular function. ...
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries. This paper reports on patients with coronary artery disease. Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous coronary intervention, or previous multi-vessel coronary artery bypass graft surgery. After a 30-day run ...
The purpose of this study is to determine whether the safety and efficacy of coronary stent implantation using Everolimus-Eluting Coronary Stent System (Abbott, Boston Scientific) is not inferior to coronary artery bypass grafting (CABG) for the treatment of patient with multivessel coronary artery disease (CAD ...
Coronary artery disease may be the leading global reason behind mortality. the best global reason behind mortality.2 A lot more than 900,000 individuals in america are affected a myocardial infarction (coronary attack) or die of CAD this season.3 Package 1 , The pathophysiology and 38390-45-3 manufacture treatment of coronary artery disease Coronary artery disease (CAD) identifies the build-up of atherosclerotic plaque in the arteries that supply air and nutrients towards the center (examined in REF 127). The complicated procedure for atherosclerosis starts early in existence and is considered to initiate with dysfunction of endothelial cells that collection the coronary arteries; these cells are no more able to properly regulate vascular firmness (narrowing or constriction from the vessels) with nitric oxide signalling. Intensifying infiltration from the vessel wall structure by lipoprotein contaminants transporting cholesterol propagates an inflammatory response by cholesterol-loaded ...
Impaired endothelial function, causing hypertension and thrombosis, is often seen in patients with coronary artery disease, ... Coronary Artery Disease. 17 (7): 611-21. doi:10.1097/01.mca.0000224420.67304.4d. PMID 17047445. S2CID 1884596. Soni D, Wang DM ... Mäyränpää MI, Heikkilä HM, Lindstedt KA, Walls AF, Kovanen PT (November 2006). "Desquamation of human coronary artery ... A Mediterranean diet has been found to improve endothelial function in adults which can reduce risk of cardiovascular disease. ...
Gundu HR Rao, S Thanikachalam (2005). Coronary Artery Disease. Jaypee Publications. p. 324. ISBN 9788180614507. Retrieved 28 ...
The global burden of disease 2004 update. Geneva: WHO. ISBN 92-4-156371-0. "Coronary Artery Disease". ... It is a disease with high mortality rate and high morbidity. Failure to treat could cause chronic kidney disease and a need for ... by a tumor or in the case of superior mesenteric artery syndrome Sickle cell disease (abnormally shaped red blood cells) ... which is the long-term accumulation of cholesterol-rich plaques in the coronary arteries. In most Western countries, Ischemic ...
Coronary Artery Disease. 38 (4): 563-573. doi:10.1016/j.ccl.2020.07.001. ISSN 0733-8651. PMID 33036718. S2CID 222255783. Kloner ... Coronary no-reflow phenomenon is specifically related to reduced antegrade coronary blood flow despite proximal coronary artery ... such as plaques within the coronary arteries. Reperfusion following ischemia causes acute inflammation within the ... It is primarily seen during percutaneous coronary intervention (PCI) in the setting of acute myocardial infarction (AMI), but ...
A 2014 meta-analysis concluded that cardiovascular disease, such as coronary artery disease and stroke, is less likely with ... Coronary Artery Disease. 27 (7): 566-572. doi:10.1097/MCA.0000000000000397. PMID 27315099. S2CID 7980392. Archived from the ... Moderate coffee consumption is not a risk factor for coronary heart disease. A 2012 meta-analysis concluded that people who ... "Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies". International ...
Coronary artery disease is the leading cause of death in the US general population. Hypercholesterolemia or high cholesterol is ... McCullough, P. A. (11 April 2007). "Coronary Artery Disease". Clinical Journal of the American Society of Nephrology. 2 (3): ... considered a major risk factor in coronary artery disease. Therefore, major efforts are focused toward understanding regulation ...
Coronary Artery Disease. 23 (6): 368-74. doi:10.1097/MCA.0b013e3283564930. PMID 22735090. S2CID 2870694. Oliveira AG, Marques ... In Alzheimer's disease (AD), the expression of A1 and A2A receptors in the frontal cortex of the human brain is increased, ... Following tissue injury in patients with Graft-versus-host disease (GVHD), ATP is released into the peritoneal fluid. It binds ... Mustafa SJ, Morrison RR, Teng B, Pelleg A (2009). "Adenosine receptors and the heart: role in regulation of coronary blood flow ...
Bell, David S.H. (October 1996). "Diabetes mellitus and coronary artery disease". Coronary Artery Disease. 7 (10): 715-722. doi ... There is also a correlation between those with diseases such as chronic kidney disease, coronary artery disease, or diabetes ... Statins are a class of drugs used to treat cardiovascular disease by lowering lipid levels, specifically LDL-C levels. Statins ... Brown, William Virgil (2018-07-12). "Clinical Lipidology and the Prevention of Vascular Disease: Time for Personalized Therapy ...
"Left anterior descending artery length in left and right coronary artery dominance". Coronary Artery Disease. 12 (1): 77-78. ...
Atherosclerosis is the leading cause of coronary artery disease. And, ischaemic heart disease is the leading cause of mortality ... "Coronary Artery Disease (CAD)". Retrieved 18 January 2021. "The top 10 causes of death". Retrieved 2 January ... Ahrens, E.H. (1979). "Dietary Fats and Coronary Heart Disease: Unfinished Business". The Lancet. 314 (8156-8157): 1345-1348. ... low cholesterol diet in secondary prevention of coronary heart disease. Advances in Experimental Medicine and Biology. Vol. 109 ...
High levels of homocysteine are linked to cardiovascular disease and atherosclerosis, particularly coronary artery disease. ... "Homocysteine and coronary artery disease". In Carmel, Ralph; Jacobsen, Ralph Carmel (eds.). Homocysteine in Health and Disease ... Refsum H, Ueland PM, Nygård O, Vollset SE (1998). "Homocysteine and cardiovascular disease". Annual Review of Medicine. 49: 31- ... has been linked to non-alcoholic fatty liver disease. This substitution has also been linked to increased frequency of non- ...
Valentin Fuster, Eric J. Topol, Elizabeth G. Nabel (2005). "Atherothrombosis and Coronary Artery Disease". p. 8. Lippincott ... In his correspondence with Heberden, he wrote: "How much the heart must suffer from the coronary arteries not being able to ... Although the disease was declared eradicated, some pus samples still remain in laboratories in Centers for Disease Control and ... No disease followed. The boy was later challenged with variolous material and again showed no sign of infection. No unexpected ...
... is a database of genes involved in coronary artery disease (CAD) . Coronary artery disease Liu, Hui; Liu Wei; Liao ... a comprehensive database for coronary artery disease genes". Nucleic Acids Res. England. 39 (Database issue): D991-6. doi: ... Cardiovascular diseases, All stub articles, Biological database stubs). ...
Nwasokwa, ON (1 October 1995). "Coronary artery bypass graft disease". Annals of Internal Medicine. 123 (7): 528-45. doi: ... upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European ... "Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from ... "ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of ...
Coronary artery disease (CAD), also known as ischemic heart disease, is responsible for 62 to 70 percent of all sudden cardiac ... 829 Structural heart diseases unrelated to coronary artery disease account for 10% of all sudden cardiac deaths. Examples of ... most commonly anomalous origin of the left coronary artery from the pulmonary artery), inflammation known as coronary arteritis ... Current cigarette smokers with coronary artery disease were found to have a two to threefold increase in the risk of sudden ...
CDC (19 July 2021). "Coronary Artery Disease ,". Centers for Disease Control and Prevention. Retrieved 7 August 2021. ... Coronary artery disease is the leading cause of death worldwide, making up 16% of all deaths. It is caused by the buildup of ... Risk factors for coronary artery disease include obesity, smoking, high cholesterol, high blood pressure, lack of exercise and ... plaque in the coronary arteries supplying the heart, eventually the arteries may become so narrow that not enough blood is able ...
"Diagnostic Imaging of Coronary Artery Disease". Lippincott Williams and Wilkins publishers. Some of his patents include; Laser ... Diagnostic imaging of coronary artery disease. Abela, George S. Philadelphia: Wolters Kluwer Health/Lippincott Williams & ... Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients with Acute Coronary and Cerebrovascular Syndromes ... "Frequency of Cholesterol Crystals in Culprit Coronary Artery Aspirate During Acute Myocardial Infarction and Their Relation to ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and ... "Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and ... is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease ...
Marmor M, Penn A, Widmer K, Levin RI, Maslansky R (2004). "Coronary artery disease and opioid use". Am. J. Cardiol. 93 (10): ... Rather than blocking a coronary artery, similar results have been seen by blocking the brachial artery using a blood pressure ... Methods to either mimic or elicit IPC have been attempted in clinical practice in the area of coronary heart disease in an ... This group exposed anesthetised open-chest dogs to four periods of 5 minute coronary artery occlusions followed by a 5-minute ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... "Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in ... "Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial ... "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Human Molecular ...
Frank ST (August 1973). "Aural sign of coronary-artery disease". N. Engl. J. Med. 289 (6): 327-8. doi:10.1056/ ...
Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction. The process ... Wang Q (2005). "Advances in the Genetic Basis of Coronary Artery Disease". Current Atherosclerosis Reports. 7 (3): 235-41. doi: ... Wang Q (2005). "Molecular genetics of coronary artery disease". Curr. Opin. Cardiol. 20 (3): 182-8. doi:10.1097/01.hco. ...
Russ was a co-editor, with Valentín Fuster and Eric J. Topol, of the textbook Atherosclerosis and Coronary Artery Disease. He ... 2005). Atherothrombosis and Coronary Artery Disease. Lippincott Williams & Wilkins. p. xxv of Preface. ISBN 9780781735834. ( ... Instead of a site for passive accumulation of blood lipids, the artery wall is now seen as a living, reactive tissue capable of ... Chronic endothelial injury hypothesis Nagourney, Eric (22 March 1999). "Russell Ross, 69, Pioneer in Artery Research". NY Times ...
Wang Q (May 2005). "Molecular genetics of coronary artery disease". Current Opinion in Cardiology. 20 (3): 182-8. doi:10.1097/ ... Presence of a constitutively active NF-κB pathway manifests in multiple myeloma and other cancer-related diseases. Removal of ... Digestive Diseases. 30 (5): 453-68. doi:10.1159/000341690. PMID 23108301. S2CID 13165828. Fernandes MT, Dejardin E, dos Santos ... but prolonged inflammation can cause serious cellular damage and increase the risk of certain diseases including cancer. Thus, ...
... severe heart failure or coronary artery disease. Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, ... Given the importance of insulin resistance as a risk factor for cardiovascular disease, it is of considerable relevance that it ... such as kidney disease and cardiac hypertrophy. Effects on insulin resistance In all animal models of insulin resistance, ... Parkinson's disease, glaucoma. Use in pregnancy is discouraged. Moxonidine passes into breast milk. Excess mortality has been ...
... coronary artery disease, cerebral vasospasm and diabetic vascular disease. There he worked with Paul M. Vanhoutte and was ... Coronary artery graft disease: mechanisms and prevention. Berlin: Springer-Verlag. 1994. ISBN 978-3-540-57438-5. OCLC 30319185 ... He says that COVID-19 is ultimately an endothelial disease and stated that "the concept that the endothelium is the main target ... He has described COVID-19 as ultimately an endothelial disease. In 2021 he addressed one of the most popular heart health ...
Gertler, Menard M.; Garn, Stanley Marion; Bland, E. F. (1950). "Age, Serum Cholesterol and Coronary Artery Disease". ... beginning with human hair and eventually contributing research on determinants of coronary artery disease, somatotype, human ... ages of thirty and fifty have their serum cholesterol rise which contributes to an increase risk for coronary artery disease. ... Garn died of complications from peripheral vascular disease on August 31, 2007, in Ann Arbor Michigan. Garn remains a pivotal ...
An autopsy showed advanced coronary artery disease. He was buried at the Northern Communal Cemetery in Warsaw. Every year ( ...
... first surgical treatments of coronary artery disease; discovery of early treatment of strep throat infections to prevent ... Performed first surgical treatment of coronary artery disease (1935) Performed first defibrillation using machine he built with ... leads the cardiac surgery team which performs President Bill Clinton's coronary artery bypass surgery. Richard Walsh, MD (Chair ... The goal of this program is to challenge students so that they affect positive change through treating disease, promoting ...
April 2020). "Polygenic Hyperlipidemias and Coronary Artery Disease Risk". Circulation: Genomic and Precision Medicine. 13 (2 ... Triglyceride Coronary Disease Genetics Consortium Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, Ricketts SL, ... May 2010). "Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies". The Lancet. 375 (9726 ... Fibrates such as fenofibrate or gemfibrozil are considered first-line therapy for the disease. Adjunctive niacin therapy can be ...
"Coronary Artery Disease (CAD)". 12 de março de 2013. Consultado o 23 de febreiro de 2015.. ... Desai, CS; Blumenthal, RS; Greenland, P (April 2014). "Screening low-risk individuals for coronary artery disease.". Current ... Centers for Disease Control and Prevention, (CDC) (14 de outubro de 2011). "Prevalence of coronary heart disease--United States ... "Conservative strategy for treatment of stable coronary artery disease". World journal of clinical cases 3 (2): 163-70. PMID ...
"Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease. The ... Gallbladder diseases are diseases involving the gallbladder and is closely linked to biliary disease, with the most common ... or gallbladder can lead to disease. Gallstones are the most common disease and can lead to other diseases, including ... Diseases of the GallbladderEdit. *Cholelithiasis (gallstones) are typically asymptomatic but can cause biliary pain ...
... coronary artery bypass surgery, abdominal surgery, endoscopic variceal sclerotherapy, radiation therapy, liver or lung ... International Review of Thoracic Diseases. 67 (1): 18-23. doi:10.1159/000029457. PMID 10705257. S2CID 45667293.. ... autoimmune disease such as systemic lupus erythematosus, bleeding (often due to chest trauma), chylothorax (most commonly ... but an accurate diagnosis of the disease that produces the fluid.[27] The traditional definitions of transudate as a pleural ...
Deaths from coronary artery disease. Hidden categories: *Articles with short description. *Short description matches Wikidata ... The official cause of death was ischemic heart disease, but it has been claimed that he intentionally starved himself. He was ...
Neurological diseases such as muscular dystrophy, amyotrophic lateral sclerosis (ALS), Guillain-Barré syndrome, myasthenia ... Tracheostomy tubes may be inserted early during treatment in patients with pre-existing severe respiratory disease, or in any ... Because mechanical ventilation serves only to provide assistance for breathing and does not cure a disease, the patient's ...
Improvement in arterial blood flow has been demonstrated in coronary arteries.[39] ... beta-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease ... Preedy VR (2 December 2011). Handbook of Growth and Growth Monitoring in Health and Disease. Springer Science & Business Media ... "Orphanet Journal of Rare Diseases. 1 (42): 42. doi:10.1186/1750-1172-1-42. PMC 1634840. PMID 17062147.. ...
... such as in coronary artery insufficiency.[6] Also an upper limit of impact energy is applied to the heart; too much energy will ... The single, most common cause of traumatic death in youth baseball". American Journal of Diseases of Children. 145 (11): 1279- ... and not the result of heart disease. The survival rate is 58%, which is an increase in comparison to years 1993-2012, where ...
A role for vitamin E in coronary heart disease was first proposed in 1946 by Evan Shute and colleagues.[112][113] More ... In theory, oxidative modification of LDL-cholesterol promotes blockages in coronary arteries that lead to atherosclerosis and ... Vogelsang A, Shute EV (June 1946). "Effect of vitamin E in coronary heart disease". Nature. 157 (3997): 772. Bibcode:1946Natur. ... Parkinson's disease[edit]. For Parkinson's disease, there is an observed inverse correlation seen with dietary vitamin E, but ...
In 2021, the principal cause of death among Malaysian adults was coronary artery disease, representing 17% of the medically ...
... coronary artery disease in coronary CT angiography (CCTA) studies.[51] Congenital heart defect[edit]. Early detection of ... coronary artery disease, congenital heart defect, pathological brain detection, fracture detection, Alzheimer's disease, and ... Commercial CADx systems for the diagnosis of bone metastases in whole-body bone scans and coronary artery disease in myocardial ... Alzheimer's disease[edit]. CADs can be used to identify subjects with Alzheimer's and mild cognitive impairment from normal ...
... it is called coronary artery disease, and in the brain, it is called cerebrovascular disease.[4] Peripheral artery disease most ... Testing for coronary artery disease or carotid artery disease is of unclear benefit.[18] While PAD is a risk factor for ... Peripheral artery disease. Other names. Peripheral vascular disease (PVD), peripheral artery occlusive disease, peripheral ... "Atherosclerotic peripheral artery disease". Clinical Key. Retrieved December 14, 2018.. *^ "Peripheral Artery Disease". The ...
Coronary artery aneurysm(英语:Coronary artery aneurysm). *Coronary artery dissection(英语:Coronary artery dissection) ... European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). *Heart Disease (页面存档备份,存于互联网档案馆) ... 病理/条件源/母体传递(英语:Template:Diseases of maternal transmission), 齐名(英语:Template:Eponymous medical signs for obstetrics) ... 橈動脈功能不全(
Redistribution indicates the existence of coronary steal and the presence of ischemic coronary artery disease.[5] ... of normal coronary arteries. This produces coronary steal from areas of ischemia where arteries are already maximally dilated. ... Rosen CJ (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168 ... It can also diagnose gallbladder diseases, e.g. bile leaks of biliary fistulas.[2] In cholescintigraphy, the injected ...
The most common cause of sudden death in the US is coronary artery disease specifically because of poor oxygenation of the ... "Progress in Cardiovascular Diseases. 51 (3): 213-228. doi:10.1016/j.pcad.2008.06.003. PMC 2621010. PMID 19026856.. ... This defect is due to an electrical node in the right ventricle just before the pulmonary artery. When the node is stimulated, ... There are many inherited conditions and heart diseases that can affect young people which can subsequently cause sudden death ...
Those with underlying coronary disease are at greater risk of cardiac effects from anaphylaxis.[17] The coronary spasm is ... Coronary artery spasm may occur with subsequent myocardial infarction, dysrhythmia, or cardiac arrest.[3][14] ... Harris JP, Weisman MH (2007-07-26). Head and Neck Manifestations of Systemic Disease. CRC Press. pp. 325-. ISBN 978-1-4200-1756 ... People with atopic diseases such as asthma, eczema, or allergic rhinitis are at high risk of anaphylaxis from food, latex, and ...
The most common cause of sudden death in the US is coronary artery disease. Approximately 300,000 people die suddenly of this ... Also, there are many inherited conditions and heart diseases that can affect young people that can cause sudden death. Many of ... Alpha-linolenic acid, cardiovascular disease and sudden death. pubmed. 2007-01-18 कथं। ...
... patients with coronary artery disease with normal BMIs were at higher risk of death from cardiovascular disease than people ... "Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review ... "US Centers for Disease Control and Prevention. 31 January 2019.. *. "BMI calculator ages 20 and older". US Centers for Disease ... The current WHO and NIH ranges of normal weights are proved to be associated with decreased risks of some diseases such as ...
Coronary Artery Disease (CAD)". 12 martie 2013. . Accesat în 23 februarie 2015. .. ... Conservative strategy for treatment of stable coronary artery disease". World journal of clinical cases. 3 (2): 163-70. PMID ... Desai, CS; Blumenthal, RS; Greenland, P (aprilie 2014). „Screening low-risk individuals for coronary artery disease". Current ... Coronary artery bypass graft surgery vs percutaneous interventions in coronary revascularization: a systematic review". JAMA. ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ... Congenital Heart Disease. 13 (5): 799-807. doi:10.1111/chd.12674. ISSN 1747-0803. PMID 30260073. S2CID 52843168.. ... the disease may also be referred to as His bundle tachycardia or congenital JET. ... a rough triangle with points at the coronary sinus, the tendon of Todaro, and the tricuspid valve).[4] ...
El-Sakka A, Morsy A, Fagih B (May 2007). "Enhanced External Counterpulsation in Patients with Coronary Artery Disease- ... "International Journal of Chronic Obstructive Pulmonary Disease. 15: 25-31. doi:10.2147/COPD.S225566. PMC 6954827. PMID 32021141 ... One theory is that ECP exposes the coronary circulation to increased shear stress, and that this results in the production of a ... So, by increasing the coronary perfusion, you allow more oxygen to perfuse the heart and ultimately generate more collateral ...
May 2007). "Aspirin resistance in patients with stable coronary artery disease with and without a history of myocardial ... After percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent, a U.S. Agency for ... The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the ... in someone with documented or suspected coronary artery disease, much lower doses are taken once daily.[152] ...
"Prognostic value of coronary artery calcium screening in subjects with and without diabetes". Journal of the American College ... Anticoagulant therapy is usually instituted to avoid life-threatening diseases, and high vitamin K intake interferes with ... coronary insufficiency, ischemia, and even heart failure. Arterial calcification might also contribute to systolic hypertension ... "Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography". ...
2005). "Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized ... 2003). "Meta-analysis of periodontal disease and risk of coronary heart disease and stroke". Oral Surg Oral Med Oral Pathol ... is not associated with coronary artery disease or retinopathy in type 2 diabetes: the Fremantle Diabetes Study". Aust N Z J Med ... "Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: ...
The origin of this artery is most commonly (80-90% of hearts) a branch of the right coronary artery, with the remainder ... Atrioventricular conduction disease (AV block) describes impairment of the electrical continuity between the atria and ... This is associated with the dominance of the coronary artery circulation. In right-dominant individuals the blood supply is ... from the right coronary artery while in left dominant individuals it originates from the left circumflex artery. Bone ...
... for coronary artery disease in multiple vessels Developed the first steerable coronary guidewire First advanced coronary ...
414.11 Aneurysm of coronary vessels 414.12 Dissection of coronary artery 414.8 Ischemic heart disease, chronic, other 414.9 ... 440 Atherosclerosis 440.1 Stenosis of renal artery 440.2 Peripheral Arterial Disease 440.21 Peripheral Arterial Disease with ... of iliac artery 443.23 Dissection of renal artery 443.24 Dissection of vertebral artery 443.29 Dissection of other artery 443.8 ... heart disease 403 Hypertensive renal disease 403.0 Malignant hypertensive renal disease 403.1 Benign hypertensive renal disease ...
Microrobot moving controlled through blood vessel for drug delivery and treatment of coronary artery disease such as CTO( ... The lab achieved the world's first microrobot navigation through artery in a live pig. Bacteria-based Biomedical Microbot Lab ...
He had severe coronary artery disease similar to Sergey Grinkov. List of sportspeople who died during their careers Olympic ...
In October 1987, Casey suffered a heart attack and underwent quadruple coronary artery bypass surgery. In 1991, during his ... To combat the disease, he underwent an extremely rare heart-liver transplant on the morning of June 14, 1993 at the University ... Though rare, the disease had also claimed the lives of Pittsburgh Mayor Richard Caliguiri and Erie Mayor Louis Tullio in 1988 ... The announcement of Casey's disease was made just days before he underwent the transplant, and as a result many accused him of ...
... and/or one of its CMTM5 proteins may promote atherosclerosis-based coronary artery disease and the stenosis of coronary artery ... Liu TF, Lin T, Ren LH, Li GP, Peng JJ (December 2020). "[Association between CMTM5 gene and coronary artery disease and the ... 350 patients with coronary artery disease were significantly higher than a matched group of 350 patients without this disease. ... Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug- ...
Learn what causes coronary artery disease (CAD) and how it is diagnosed. Get the facts from the CDC. ... What is coronary artery disease?. Coronary artery disease (CAD) is the most common type of heart disease in the United States. ... Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary ... Learn the facts about heart disease, including coronary artery disease, the most common type of heart disease. ...
... patients with coronary artery disease can manage their condition and lead healthy lives. ... Coronary artery disease (otherwise known as CAD) is the most common type of heart disease in the United States and the leading ... Coronary Artery Disease. Last updated November 1, 2016.. NIH: National Heart, Lung, and Blood Institute. What Is Coronary Heart ... Health Topicsheart healthheart diseaseHeart-Healthy Treatments for Coronary Artery Disease. ...
... including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in ... Infliximab treatment for refractory Kawasaki disease with coronary artery aneurysm Circ J. 2008 May;72(5):850-2. doi: 10.1253/ ... including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in ...
Health Information on Coronary Artery Disease: MedlinePlus Multiple Languages Collection ... Coronary Artery Disease: MedlinePlus Health Topic - English Enfermedad de las arterias coronarias: Tema de salud de MedlinePlus ... Coronary Artery Disease (CAD) - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF ... Coronary Artery Disease (CAD) - 繁體中文 (Chinese, Traditional (Cantonese dialect)) Bilingual PDF ...
This article reviews the pharmacotherapeutic options for stable ischemic heart disease, including beta-blockers, calcium ... Management of Coronary Artery Disease and Chronic Stable Angina. Yesenia Camero, PharmD, BCPS; Jinwi Ghogomu, PharmD, BCPS, CPh ... Coronary angiography uses a contrast material and x-rays to show how blood flows through the coronary arteries.[5] Patients in ... still have persistent ischemic symptoms may benefit from coronary angiography. Coronary angiography may be able to define the ...
Certain aspects of coronary artery disease (CAD) can be different for women compared with men. Heres what you need to know. ... The most common type of heart disease is coronary artery disease (CAD). You might also hear the name coronary heart disease. ... Articles On Risks of Coronary Artery Disease * Risk Factors for Heart Disease ... Coronary Artery Disease and Women Written by Evan Starkman. Medically Reviewed by James Beckerman, MD, FACC on October 26, 2021 ...
... is a complex disease that causes reduced or absent blood flow in one or more of the arteries that encircle and supply the heart ... encoded search term (Coronary Artery Disease Imaging) and Coronary Artery Disease Imaging What to Read Next on Medscape ... Coronary artery disease (CAD) is a complex disease that causes reduced or absent blood flow in 1 or more of the arteries that ... Coronary revascularization is the most important treatment strategy for coronary artery disease. Percutaneous coronary ...
... ... We evaluated 3 new markers for coronary artery disease [‎CAD]‎ [‎bilirubin, total homocysteine [‎t-Hcy]‎ and high-sensitivity C ... 2007)‎. Diagnostic value of homocysteine, C-reactive protein and bilirubin for coronary artery disease. EMHJ - Eastern ... protein [‎hs-CRP]‎]‎ in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group [‎n = 262 ...
Coronary artery disease (CAD) is the most common type of heart disease. It is caused by a narrowing of the major vessels that ... What is Coronary Artery Disease?. Coronary artery disease (CAD) is the most common type of heart disease. It is caused by a ... How is coronary artery disease treated?. You and your cardiologist work together to create your best treatment plan. Your plan ... Coronary artery disease develops over decades and may have no symptoms.. If you are experiencing severe chest pain, numbness on ...
In this session, a complex coronary case is presented. All symptoms, patient characteristics and test results are described in ...
Optimal medical therapy unarguably forms the cornerstone of management for patients with stable coronary artery disease. There ... Role of Fractional-Flow Reserve in Guiding Percutaneous Revascularization in Stable Coronary Artery Disease Curr Atheroscler ... Optimal medical therapy unarguably forms the cornerstone of management for patients with stable coronary artery disease. There ... reserve evaluation in guiding percutaneous revascularization procedures for patients with stable coronary artery disease and ...
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at genome-wide significance (P ... Watkins and colleagues meta-analyze data from the UK Biobank along with recent genome-wide association studies for coronary ... artery disease. They identify 13 new loci that were genome-wide significant and 243 loci at a 5% false discovery rate. ... Association analyses based on false discovery rate implicate new loci for coronary artery disease. *Christopher P Nelson1,2 na1 ...
... had left main coronary disease, 747 (68%) patients had single vessel disease, 181 (17%) had two-vessel disease and that 155 (14 ... Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by ... or coronary bypass graft (CABG) from 2010 to 2012. Data on demographic features, cardiovascular risk factors, and angiographic ... had three-vessel disease. The most common anatomical involvement was the anterior wall territory. Conclusion: Young CAD ...
Have coronary artery bypass surgery Have coronary artery bypass surgery *The surgery can take 3 to 6 hours. You will stay in ... What is coronary artery bypass surgery?. Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood ... What is coronary artery bypass surgery?. Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood ... Coronary Artery Disease: Should I Have Bypass Surgery?. Heres a record of your answers. You can use it to talk with your ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
One of the first studies of its kind has found integrated PET/CT to be a highly accurate method for diagnosing coronary artery ... disease. The combined imaging approach can help physicians decide whether to treat these patients with revascularization or ... PET/CT tops angiography in coronary artery disease diagnosis. .social-ris-container { display: flex; justify-content: space- ... One of the first studies of its kind has found integrated PET/CT to be a highly accurate method for diagnosing coronary artery ...
coronary artery disease Blogs, Comments and Archive News on ... coronary artery disease Latest Breaking News, Pictures, Videos, and Special Reports from The Economic Times. ... Eating food filled with transfat increases the risk of coronary heart disease by clogging the arteries; which is why, FSSAI has ... A higher intake of refined grains can make you vulnerable to premature coronary artery disease. ...
Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary ... p> Relevant updates to the text are sourced regularly from the parent reference, Braunwalds Heart Disease and ... This brand-new companion to Braunwalds Heart Disease was designed as a stand-alone reference for physicians ... Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes ...
... cardiovascular disease (CVD) was the primary cause in 864,480 deaths (35.3% of total) and the secondary cause in another ... Primary and Secondary Prevention of Coronary Artery Disease) and Primary and Secondary Prevention of Coronary Artery Disease ... Women and Coronary Artery Disease. In the United States, coronary heart disease (CHD) is the leading cause of death in men and ... Primary and Secondary Prevention of Coronary Artery Disease * Sections Primary and Secondary Prevention of Coronary Artery ...
Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease ( ... had been divided into groups by the coronary angiography (CAG), namely, stable CAD: ,span class=inline_break,,svg xmlns:xlink ... levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. Nevertheless, the issue ... including coronary artery disease (CAD), heart failure, peripheral arterial disease, and cerebrovascular disease [1]. CAD is ...
Urgent coronary arteriography showed severe coronary artery disease (Figure 2). Left ventriculography showed an ejection ... Relation of diagonal ear lobe crease to the presence, extent, and se verity of coronary artery disease determined by coronary ... Bilateral earlobe creases and coronary artery disease. Abhishek Sharma, MD, Chukwudi Obiagwu, MD and Ekaterina Sikorskaya, MD ... Sanders T. Frank, in 1973, first described a diagonal wrinkle-like line on the earlobe as a sign of coronary artery disease.1 ...
... ... We evaluated 3 new markers for coronary artery disease [‎CAD]‎ [‎bilirubin, total homocysteine [‎t-Hcy]‎ and high-sensitivity C ... 2007)‎. Diagnostic value of homocysteine, C-reactive protein and bilirubin for coronary artery disease. EMHJ - Eastern ... protein [‎hs-CRP]‎]‎ in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group [‎n = 262 ...
Learn about coronary artery disease, risk factors and treatment at Mayo Clinic Health System in Faribault. ... Coronary Artery Disease Coronary artery disease develops when the major blood vessels ― the coronary arteries ― that supply ... salt and sugar can increase your risk of coronary artery disease. If you have risk factors for coronary artery disease, such as ... diabetes is associated with an increased risk of coronary artery disease. Type 2 diabetes and coronary artery disease share ...
Foreword: changing the treatment paradigm for coronary artery disease. *. Caldwell B. Esselstyn Jr., MD Caldwell B. Esselstyn ... National Conference on Lipids in the Elimination and Prevention of Coronary Artery Disease presented by the Cleveland Clinic ... Post-Coronary Artery Bypass Graft Trial Investigators. The effect of aggressive lowering of low-density lipoprotein cholesterol ... Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at ...
Our objectives were: (1) to develop an algorithm that would enable the study of coronary artery disease (CAD) across diverse ... There is increasing interest in analyses which can allow study of a specific outcome across different diseases. Such a study in ... Additionally, we demonstrate how to implement CAD algorithm to compare risk across 3 chronic diseases in a preliminary study. ... inflammatory bowel disease (IBD, n = 10,974), and rheumatoid arthritis (RA, n = 4,453) from two large academic centers. We ...
Coronary artery disease (CAD) is the narrowing of the blood vessels due accumulation of fat leading to plaque formation. . The ... What is coronary artery disease?. Coronary artery disease develops because of obstruction in your coronary arteries. This ... Left circumflex artery. What causes coronary artery disease?. Coronary artery disease is caused by the build-up of plaques ... What are the warning signs of clogged arteries?. Coronary artery disease symptoms may take years to develop. In most cases, ...
Coronary artery disease (CAD), also called coronary heart disease, is a condition in which plaque (plak) builds up inside the ... When plaque builds up in the arteries, the arteries harden.. CAD is the most common type of heart disease.. Its the leading ... coronary arteries. These arteries supply your heart muscle with oxygen-rich blood.. Plaque narrows the arteries and reduces ... It also makes it more likely that blood clots will form in your arteries. Blood clots can partially or completely block blood ...
We are a national leader in the treatment of these completely blocked arteries, including robotic heart surgery and ... When a coronary artery blockage lasts for three months or more, its referred to as a chronic total occlusion (CTO). ... As the hearts arteries become narrowed over time due to atherosclerosis (the buildup of plaque) and coronary artery disease, ... It offers an option to those whose quality of life is impacted by their coronary artery disease. Henry Ford is Michigans most ...
Overview of Coronary Artery Disease (CAD) - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - ... What causes coronary artery disease? The most common cause of coronary artery disease is atherosclerosis Atherosclerosis In ... How do doctors treat coronary artery disease? Doctors treat the problem thats causing your coronary artery disease, which is ... Coronary artery disease (heart disease) happens when blood flow through the coronary arteries is partially or totally blocked. ...
... had left main coronary disease, 747 (68%) patients had single vessel disease, 181 (17%) had two-vessel disease and that 155 (14 ... Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by ... or coronary bypass graft (CABG) from 2010 to 2012. Data on demographic features, cardiovascular risk factors, and angiographic ... had three-vessel disease. The most common anatomical involvement was the anterior wall territory. Conclusion: Young CAD ...
  • The evaluation of patients with SIHD includes coronary angiography, which is considered the gold standard for CAD diagnosis. (
  • [ 4 ] Coronary angiography uses a contrast material and x-rays to show how blood flows through the coronary arteries. (
  • [ 5 ] Patients in whom SIHD is suspected who have unacceptable ischemic symptoms and who, despite guideline-directed medication therapy, still have persistent ischemic symptoms may benefit from coronary angiography. (
  • Coronary angiography may be able to define the extent and severity of CAD in patients in whom SIHD is suspected. (
  • Coronary angiography may also be beneficial in patients who cannot undergo stress testing or have an indeterminate or nondiagnostic stress test when there is a high likelihood that findings may result in changes to therapy. (
  • Additionally, coronary angiography may be considered in patients with acceptable stress-test results not suggestive of the presence of CAD when clinical suspicion of CAD remains high and the likelihood is great that findings may result in changes to therapy. (
  • Newer technologies such as CT fractional flow reserve, CT angiography with perfusion, and whole-heart coronary magnetic resonance angiography with perfusion, which can provide both anatomic and functional information in the same test, obviate the need for multiple diagnostic tests to obtain a comprehensive assessment of both plaque burden and downstream ischemia. (
  • Nonetheless, owing to limitations of coronary angiography and conventional non-invasive functional testing for myocardial ischemia, targeting of hemodynamically significant coronary stenoses for revascularization is often difficult. (
  • Standard imaging with coronary angiography is costly compared with alternatives such as CT angiography or intravascular coronary ultrasound. (
  • An average 30% of coronary angiograms yield clinically insignificant disease, and angiography cannot predict the physiologic implications of stenoses such as ischemic recurrence or vessel reocclusion after lytic therapy. (
  • An imaging test that combines functional and anatomic capabilities could render coronary angiography unnecessary. (
  • They had previously undergone coronary angiography for recurrent chest pain. (
  • The investigators compared PET/CT with PET plus coronary angiography. (
  • In A, coronary angiography showed 80% stenosis of the mid-left anterior descending artery (red arrow), chronic total occlusion of the left circumflex artery (white arrow), and in B, mild to moderate diffuse atherosclerosis of the right coronary artery (arrows). (
  • Intrusive Coronary Angiography (ICA), a physical test, is viewed as the best quality level technique for the finding of computer aided design. (
  • Clinicians can browse many painless tests, including exercise electrocardiography, single photon outflow registered tomography myocardial perfusion imaging positron emanation tomography, stress echocardiography, coronary processed tomography angiography, and stress cardiovascular attractive reverberation. (
  • A large number of people who undergo elective coronary angiography are found to have nonobstructive coronary artery disease, and these patients have significantly increased risk for myocardial infarction and death, according to a retrospective study published in JAMA . (
  • The absence of observable disease by angiography does not completely rule out non-obstructive disease where the lumen remains normal in size but the wall of the vessel bulges outward as noted by Glagov a few decades ago. (
  • Comparing the above results to what has been seen with the use of coronary calcium imaging creates a strong argument for increased use of CAC screening and a reduced use of stress imaging and angiography. (
  • This article describes coronary artery nomenclature using computerized tomography angiography and virtual angioscopy. (
  • Purpose: To determine the relationship between established cardiovascular risk factors, clinical presentation and the extent of coronary artery disease (CAD), as described with computed tomography coronary angiography. (
  • MATERIAL AND Methods: In this cross-sectional study, we included 567 symptomatic individuals without a history of CAD who consecutively underwent 64-slice computed tomography coronary angiography for evaluation of suspected CAD. (
  • Conclusion: Computed tomography coronary angiography may play an important role in risk stratification of patients with suspected CAD. (
  • Methods The AHES is an observational study that surveyed 1680 participants between 2009 and 2012 who presented to a tertiary referral hospital for the evaluation of potential CAD by coronary angiography. (
  • This is called atherosclerosis CAD can result in coronary heart disease also called ischemic heart disease. (
  • Objective: Due to devastating consequences of coronary artery disease (CAD) in young population, this study was designed to evaluate the prevalence of preventable risk factors and severity of atherosclerosis for Iranian young adults (≤45 years) diagnosed with premature CAD. (
  • Although atherosclerosis of the coronary arteries is less prominent in young patients, more often it is accompanied by decreased left ventricular function. (
  • 1 Subsequently, autopsy studies suggested that deep bilateral earlobe creases could be an important sign of coronary atherosclerosis. (
  • High blood cholesterol levels - high levels of cholesterol in your blood can increase the risk of plaque formation and atherosclerosis - the buildup of plaque in and on your artery walls. (
  • Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). (
  • As the heart's arteries become narrowed over time due to atherosclerosis (the buildup of plaque) and coronary artery disease, they can become completely blocked. (
  • Atherosclerosis In people with atherosclerosis, patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or blocked. (
  • In atherosclerosis, cholesterol and other fatty material slowly build up in your arteries. (
  • Coronary artery disease usually results from the build-up of fatty material and plaque, a condition called atherosclerosis. (
  • Atherosclerosis is a diffuse infection that influences numerous supply routes of the body, in addition to the coronary veins. (
  • The information gained from these In vitro studies is then used in a targeted fashion to investigate the role of the candidate gene in models of In vivo cardiovascular disease, in particular the development and regression of atherosclerosis and models of altered vascular function such as vascular injury and ischaemia models. (
  • A typically In vitro project would involve investigating the expression profile gene of interest in human tissue (e.g. arteries with or without atherosclerosis and cells (e.g endothelial cells, vascular smooth muscle cells and inflammatory cells) implicated in coronary artery disease. (
  • We will evaluate physiological parameters such as blood pressure and contractile and dilator function of blood vessels before going on to investigate the role of the candidate gene in vascular pathology using models of atherosclerosis and vascular disease. (
  • In recent times many companies have developed therapeutic strategies able to delivery engineered genetic products within the human tissues, and if the present study will confirm that MEF2A is associated with atherosclerosis, a targeted delivery of a modified version of the MEF2A gene within the arterial cells might represent a future therapeutic option able to revert atherosclerosis in subject with occluded arteries, or at least to prevent future cardiovascular events. (
  • The last few years have seen a surge of interest in the measurement of coronary artery calcification to predict and monitor the presence of coronary atherosclerosis. (
  • Objective This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese). (
  • According to the National Library of Medicine, part of the NIH (National Institutes of Health), USA, garlic is widely used for several conditions linked to the blood system and heart, including atherosclerosis (hardening of the arteries), high cholesterol, heart attack, coronary heart disease and hypertension. (
  • Angina can happen when too much plaque builds up inside arteries, causing them to narrow. (
  • Cipla said, Metoprolol succinate extended-release tablets are indicated for the treatment of hypertension, to lower blood pressure, Angina Pectoris (chest pain or discomfort due to coronary heart disease). (
  • Introduction: An estimated seven million American adults live with coronary artery disease and chronic angina. (
  • Unstable Angina) Acute coronary syndromes result from a sudden blockage in a coronary artery. (
  • As the coronary arteries narrow, the flow of blood to the heart can slow or stop, causing chest pain (stable angina), shortness of breath, heart attack, or other symptoms. (
  • Someone may first notice that they have it after experiencing angina symptoms, but Coronary Artery Disease can also cause a heart attack without any previous symptoms. (
  • Understand how coronary artery disease develops and know the difference between angina and heart attack. (
  • Methods Forty eight patients with CHD (37 with ACS [23 patients with ST segment myocardial infarction (STEMI) and 14 with non-ST segment elevation myocardial infarction (NSTEMI)] and 11 with stable angina (SA) treated with percutaneous coronary intervention (PCI) were recruited. (
  • A growing number of patients, particularly those with advanced, chronic coronary artery disease, experience symptoms of angina that are refractory to treatment with β-blockers, calcium-channel blockers, and long-acting nitrates, despite revascularization. (
  • Figure 4: Successful percutaneous coronary intervention for chronic total occlusion is associated with reduced angina frequency. (
  • The most common symptom of coronary artery disease is angina. (
  • I25.119 is a valid billable ICD-10 diagnosis code for Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris . (
  • Lifestyle, environmental factors, and genetic factors pose as risk factors for the development of cardiovascular disease. (
  • Nuts are full of unsaturated fatty acids, fibre, vitamin E, and reduce risk of cardiovascular disease in diabetics. (
  • Despite relatively recent declines in age-adjusted mortality, in 2013, cardiovascular disease (CVD) was the primary cause in nearly 801,000 deaths (30.8% of total deaths) in the United States. (
  • [ 9 ] This demonstrates that a different approach to behavior change is needed, particularly in developing countries where cardiovascular disease rates are rising. (
  • The #1 cause of death in adults is: cardiovascular disease. (
  • In fact, except for 1918, when there was an influenza outbreak in the US, cardiovascular disease has been the #1 cause of death (in adults) every single year since 1900! (
  • Cardiovascular disease" represents a collection of distinct disease states: coronary artery disease (CAD), hypertension, stroke, congestive heart failure, and several others. (
  • It's estimated that more than 1 in 3 adults has one or more risk factors for cardiovascular disease (Benjamin EJ, et al. (
  • However, currently, more women than men die of cardiovascular disease annually in the US. (
  • Cardiovascular disease kills 10 times as many women each year than does breast cancer (see table below). (
  • In fact, cardiovascular disease kills more women than the next 14 causes of death combined. (
  • Genome wide association studies have enabled us to identify genes which are associated with cardiovascular disease at the level of the whole genome. (
  • However, the challenge now is to establish the role of these genes in the pathology of cardiovascular disease. (
  • The work in my lab aims to establish the role of novel candidate genes in cardiovascular disease. (
  • Once candidate genes have been identified we use targeted cardiovascular disease relevant in vitro cell based assays in primary human cells to understand how the candidate gene impacts and cell function. (
  • Doctoral students have the flexibility to focus either on in vitro cell based assays or in vivo models of cardiovascular disease. (
  • We are part of a wider scientific community with expertise in Cardiovascular Disease allowing for collaborative work with other senior scientist. (
  • By the end of this project the candidate will have developed a wide range of laboratory skills such as molecular biology techniques (protein and RNA analysis), cell culture techniques and In vivo models of cardiovascular disease. (
  • It has long been noted that AMD shares many risk factors with cardiovascular disease (CVD). (
  • Gene-centered association of a high density SNP panel of the MEF2A gene with Cardiovascular disease. (
  • The aim of this study is to interrogate UK Biobank databank, by extracting genetic data of the Myocyte Enhancer Factor 2A (MEF2A) gene and try understand if small genietc variations of the gene do associate with the features of the cardiovascular disease filed in the databank. (
  • These studies then suggest that genetic mutations in the MEF2A gene, able to reduce the gene functionality, might be associated with an increased risk of cardiovascular disease. (
  • The identification of MEF2A as a possible determinant of cardiovascular disease and coronary artery disease might open the field for novel therapeutic strategies in the treatment of such conditions. (
  • People with cardiovascular disease or who are at high cardiovascular risk (due to the presence of one or more risk factors such as hypertension, diabetes, hyperlipidaemia or already established disease) need early detection and management using counselling and medicines, as appropriate. (
  • According to the results of questionnaire and electrocardiogram, all subjects were free of hypertension, hyperlipemia, cardiovascular disease, and diabetes mellitus. (
  • Epidemiologic studies of cardiovascular disease in exposed workers from Pennsylvania, Finland, and Belgium were quoted. (
  • Customers established the first listed for a patient and delivery of the treatment of both healthcare conditions that can be used in herbs to lower blood pressure Dr. Axe patients with diabetes and cardiovascular disease. (
  • resistance of occurrence in the patient's coronary arteries Jewish Ledger that makes it a positive effect of cardiovascular disease and heart attacks to the future. (
  • More than 13,000 cardiovascular team members came together to focus on the prevention, diagnosis, and treatment of cardiovascular disease. (
  • Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort - Am J Clin Nutr 2021 Nov 12 - 'Vascular calcification contributes to cardiovascular disease (CVD) and mortality in individuals with chronic kidney disease (CKD). (
  • Cardiovascular disease (CVD) represents the leading cause of death worldwide. (
  • His research interests include diagnostic imaging, 3D medical image visualization and processing, haemodynamic analysis of cardiovascular diseases and 3D printing in cardiovascular disease. (
  • Because U.S. veterans cared for at the U.S. Department of Veterans Affairs are older and have more cardiovascular disease (CVD) risk factors than the general U.S. population, veterans are at risk for cardiac complications of influenza infection. (
  • Percutaneous coronary intervention (PCI) has become the most frequently performed procedure. (
  • We discuss the role of invasive fractional-flow reserve evaluation in guiding percutaneous revascularization procedures for patients with stable coronary artery disease and its potential impact on outcomes for these patients. (
  • Method: A cross sectional, descriptive study comprised 1093 consecutive patients (≤45 years), with a diagnosis of CAD, who underwent percutaneous intervention (PCI) or coronary bypass graft (CABG) from 2010 to 2012. (
  • Guan W, Lu H, Yang K. Choosing between ticagrelor and clopidogrel following percutaneous coronary intervention: A systematic review and Meta-Analysis (2007-2017). (
  • Dual antiplatelet therapy with compared to aspirin alone after percutaneous coronary intervention modestly reduces nonfatal events like heart attack and stroke. (
  • The systematic review summarized here 3 included 11 trials and 5 observational studies that in aggregate enrolled 25,805 subjects with acute coronary syndrome undergoing percutaneous coronary intervention as well as those with stable CAD. (
  • The 2016 ACC/AHA Guideline "Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease," makes a class IIa recommendation that ticagrelor is preferential to clopidogrel for both non-ST-elevation acute coronary syndrome and ST-elevation myocardial infarction and patients who undergo percutaneous coronary intervention. (
  • This dual antiplatelet therapy (DAPT) is still indicated for secondary coronary prevention after either an acute coronary syndrome (ACS) or a planned percutaneous coronary intervention (PCI). (
  • Previous models for contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) include procedure-related variables in addition to pre-procedural variables. (
  • What are the symptoms of coronary artery disease? (
  • If you're at high risk for heart disease or already have symptoms, your doctor can use several tests to diagnose CAD. (
  • Pain and tightness in the chest are common symptoms of coronary artery disease, but many prescription medications can offer relief. (
  • But certain aspects of the disease, like the risk factors and symptoms, can be different for you. (
  • Many women don't have symptoms of coronary artery disease, or they're different from the "classic" ones that men have. (
  • Coronary artery disease develops over decades and may have no symptoms. (
  • Eventually, the decreased blood flow may cause chest pain, shortness of breath, or other coronary artery disease signs and symptoms. (
  • He or she may want to test you for coronary artery disease, especially if you have signs or symptoms of narrowed arteries. (
  • In many cases, coronary artery disease symptoms develop only at later stages. (
  • Coronary artery disease symptoms may take years to develop. (
  • It is also a common misconception that, since it is heart disease, its symptoms arise only in and around your heart. (
  • Sometimes there are no symptoms of completely blocked arteries. (
  • The main goals of treatment for Coronary Artery Disease are to relieve symptoms and prevent complications. (
  • Whereas subjects with significant obstruction are at higher risk for MI, the majority of heart attacks occur in subjects without obstructive disease, who had no symptoms prior to the plaque rupturing and the vessel obstructing with thrombus. (
  • If we know a person has a calcium score high enough to justify treatment, why would we feel any need to seek out obstructive disease unless there are life altering symptoms? (
  • So if you have a suspicion, based on symptoms or the disease process, you begin with serology. (
  • And even in the emergency room, doctors often dismiss the subtler symptoms of heart disease in women as anxiety, indigestion, or fatigue-when in fact the real issue is the heart. (
  • While men tend to get the "classic" symptoms of heart disease that we're all familiar with, such as chest pain and shortness of breath, women's heart disease symptoms can be much subtler. (
  • For some, the symptoms of heart disease in women are so mild that they can be mistaken for the flu. (
  • 2 Diagonal earlobe creases have been shown to be independently associated with increased prevalence, extent, and severity of coronary artery disease. (
  • OBJECTIVE - To determine the risk factors prevalence for coronary artery disease in the State of Rio Grande do Sul, Brazil and to identify their relation with the age bracket. (
  • CONCLUSION - The prevalence of the major risk factors for coronary artery disease in the Brazilian state of Rio Grande do Sul could be determined in a study that integrated public and private institutions. (
  • Background/aims To describe the prevalence of early, late and any age-related macular degeneration (AMD) in a clinical cohort (Australian Heart Eye Study, AHES) and to determine whether associations exist between extent and severity of coronary artery disease (CAD) and AMD, independent of traditional cardiovascular risk factors. (
  • In this sense, the objective of the present study was to evaluate, using Brief IPQ and DS-14 Scale, the relationship between the perception of disease and the prevalence of Type D Personality in 80 patients with CAD during hospitalization. (
  • The prevalence of common CVD diagnoses (hypertension, coronary heart disease, atrial fibrillation and flutter, heart failure, ischemic stroke, and venous thromboembolism) was evaluated as a function of the patients' body height stratified by age and sex. (
  • In both sexes, the prevalence of hypertension, coronary heart disease, heart failure, and ischemic stroke was higher among patients of smaller body height. (
  • Estimates of prevalence of heart attacks and ischemic heart disease are largely based on survey samples (e.g. (
  • These indicators include data on the crude and age-adjusted rate of coronary heart disease and the prevalence of adults ever diagnosed with stroke. (
  • It is sometimes called coronary heart disease or ischemic heart disease. (
  • In the United States, the most common type of heart disease is coronary artery disease (CAD, or ischemic heart disease), which can lead to heart attack. (
  • Data can be used to identify trends and patterns in the mortality of ischemic heart disease, heart attacks, or stroke. (
  • A computed tomography (CT) scan that looks in the coronary arteries for calcium buildup and plaque. (
  • DelveInsight's, "Coronary Artery Disease Pipeline Insight, 2022" report provides comprehensive insights about 30+ Coronary Artery Disease companies and 30+ pipeline drugs in Coronary Artery Disease pipeline landscape. (
  • 'Coronary Artery Disease Pipeline Insight, 2022' report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. (
  • Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary arteries). (
  • Plaque buildup causes the inside of the arteries to narrow over time. (
  • CAD is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. (
  • Plaque is made up of deposits of cholesterol and other substances in the artery. (
  • Plaque buildup causes the inside of the arteries to narrow over time, which can partially or totally block the blood flow. (
  • Characterized by a buildup of cholesterol plaque in the arteries, CAD gradually reduces and impairs blood flow to the heart. (
  • When plaque builds up, it narrows your coronary arteries, decreasing blood flow to your heart. (
  • The build-up of plaque causes your artery walls to shrink or get stiffened. (
  • If you wonder what coronary heart disease is, it inhibits the normal functioning of your heart by building up of plaque in the arteries, the rate at which the plaque gets piled up differs from person to person. (
  • Your body reacts to it by sending white blood cells to fight the plaque, as a result, it causes inflammation in your arteries. (
  • Coronary artery disease (CAD), also called coronary heart disease, is a condition in which plaque (plak) builds up inside the coronary arteries. (
  • Plaque narrows the arteries and reduces blood flow to your heart muscle. (
  • When plaque builds up in the arteries, the arteries harden. (
  • This may also happen suddenly, when plaque ruptures in an artery and forms a clot. (
  • While we usually think of CAD as a plumbing problem arising from the build-up of fatty plaque inside major arteries -- and it is! (
  • At the point when a weak plaque breaks, it invigorates the nearby development of a blood coagulation that can impede the progression of blood to the heart muscle and cause the unexpected beginning of a coronary episode (myocardial dead tissue). (
  • Within the coronary circulation, the calcium score correlates closely with plaque apatite content. (
  • Necropsy studies have shown that the amount of intimal calcium in the coronary arteries is related closely to the amount of plaque. (
  • Furthermore, a direct relation has been demonstrated between coronary artery calcium score, as measured by EBCT, and histological measures of plaque burden. (
  • The reason is that women's hearts-physiologically speaking-are smaller than men's hearts, and their arteries are narrower-making them more prone to plaque buildup. (
  • Although pneumonia is the most common complication of influenza infection, influenza is also associated with exacerbations of underlying medical conditions, including chronic cardiac diseases (e.g., congestive heart failure and atrial fibrillation) [ 3 , 4 ]. (
  • This study reported more severe disease outcomes in patients with hypertension. (
  • Some major risk factors for coronary artery disease have been very well established 2 , such as systemic arterial hypertension, smoking, dyslipidemias, obesity, sedentary lifestyle, diabetes mellitus, and familial antecedents. (
  • 20 Although consistent and moderate associations were found between AMD and a history of CVD, hypertension and higher body mass index (BMI), other CVD risk factors such as history of cerebrovascular disease, diabetes and hyperlipidaemia were found to have relatively weak and inconsistent associations with AMD. (
  • Cardiac disease secondary to occupational lung disease was a result of pulmonary hypertension. (
  • Pulmonary hypertension is high blood pressure in the arteries of the lungs. (
  • We describe perioperative anesthetic management of a patient having severe left main coronary artery stenosis (LMCAS) with severe triple vessel coronary artery disease (TVD). (
  • Checks the inside of your arteries for blockage by inserting a thin, flexible tube through an artery in the groin, arm, or neck to reach the heart. (
  • Monitors blockage and flow of blood through the coronary arteries. (
  • Depending on the degree of blockage in your arteries, your doctor or cardiologist may recommend prescription medications, in addition to healthy lifestyle habits, to reduce the effects of coronary artery disease. (
  • Because coronary artery disease often develops over decades, you may not notice a problem until you have a significant blockage or a heart attack. (
  • literally "hardening of the arteries," which involves fatty deposits in the artery walls and may progress to narrowing and even blockage of blood flow in the artery), occurs in about 2 to 9% (depending on sex and race) of people aged 20 and older. (
  • Various coronary arteries are shown in varied stages of blockage. (
  • It may also mean that the liver is incapable of adequately removing bilirubin in a timely manner due to blockage of bile ducts, liver diseases (such as cirrhosis, acute hepatitis), or inherited problems with bilirubin handling. (
  • This patient's presentation and evaluation remind us that bilateral earlobe creases may be useful to include in the clinical examination of patients with suspected coronary artery disease and may facilitate early recognition of disease in a patient at high risk. (
  • Apart from rare congenital anomalies (birth defects), coronary artery disease is usually a degenerative disease, uncommon as a clinical problem before the age of 30 years and common by the age of 60 years. (
  • Congenital Heart Disease 2017 , 12 (5), 603-606. (
  • Anomalous aortic origin of a coronary artery is a congenital abnormality of the origin or course of a coronary artery that arises from the aorta. (
  • As commonly seen in congenital heart disease, a wide spectrum of anatomic variability is seen and hence, it is important for clinicians to document the precise anatomy and course of the anomalous vessel. (
  • Other CVDs include peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure. (
  • Congenital heart disease (CHD) is a problem with the heart's structure and function that is present at birth. (
  • Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. (
  • There are at present two basically identical strategies for the perception and evaluation of coronary supply route calcification - electron bar computer tomography and multidetector registered tomography. (
  • Primer examinations propose that coronary calcification adds data in the subset of people who are viewed as at transitional gamble since they have various customary gamble factors. (
  • Vascular calcification occurs in both the intima and the media of arteries, and there is evidence that these two sites of calcification are distinct entities (table 1 ). (
  • 5 It has therefore been suggested that the high ischaemic heart disease mortality rates in patients with renal failure may be partly attributable to increased vascular calcification. (
  • Medial calcification is unusual in the coronary arteries and therefore any detectable coronary calcification is taken to reflect calcium within intimal atherosclerotic lesions. (
  • Although IVUS is highly sensitive and specific for calcification, it is invasive, non-quantitative, and only visualises a limited portion of the coronary tree. (
  • The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial - Am J Clin Nutr 2021 Oct 12 - 'In individuals with diabetes mellitus, supplementation with 10 mg vitamin K1/d may prevent the development of newly calcifying lesions within the aorta and the coronary arteries as detected using 18F-NaF PET. (
  • Kaohsiung J Med Sci 2021 Feb 26 - 'The present cross-sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K-dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. (
  • Introduction Inflammation and platelet activation play a pivotal role in the pathogenesis of acute coronary syndrome (ACS). (
  • Patients with coronary artery disease (CAD) presenting with acute coronary syndrome or undergoing coronary stenting are indicated to treatment with dual antiplatelet therapy (DAPT) combining aspirin with a P2Y12 receptor inhibitor. (
  • An observational study to assesss the risk factors in acute coronary syndrome at a tertiary cate hospital. (
  • The death certificate lists acute myocardial infarction and coronary artery disease as the causes of death. (
  • Despite the widespread recognition of pyuria in acute Kawasaki disease (KD) patients and its inclusion in the American Heart Association list of supporting laboratory data for KD diagnosis, no systematic study of pyuria and the origin of these cells in KD patients have been reported. (
  • Although timely diagnosis and treatment with intravenous immunoglobulin (IVIG) are critical to reduce the incidence of coronary artery aneurysms, 8 diagnosis of KD is still established based on clinical criteria supported by laboratory evidence of acute inflammation and there is no specific diagnostic test to aid the clinician. (
  • Flow-mediated-paradoxical vasoconstriction is independently associated with asymptomatic myocardial ischemia and coronary artery disease in type 2 diabetic patients. (
  • You need a cardiac catheterization and coronary artery angiogram to know if you have a chronic total occlusion. (
  • New treatment principles are emerging in current practice, such as metabolic modulation, therapeutic angiogenesis, and novel interventional techniques (coronary in-flow redistribution and approaches to chronic total occlusion). (
  • chronic total occlusion of coronary artery ( I25.82 ) exposure to environmental tobacco smoke ( Z77.22 ) history of tobacco dependence ( Z87.891 ) occupational exposure to environmental tobacco smoke ( Z57.31 ) tobacco dependence ( F17 . (
  • Patients with obstructive coronary stenosis in all three main coronary arteries (segment score) had greater than twofold higher likelihood of early AMD, OR 2.67 (95% CI 1.24 to 5.78). (
  • Conclusions Severity of coronary stenosis and the presence of stenotic lesions were independently associated with early AMD. (
  • Optimal medical therapy unarguably forms the cornerstone of management for patients with stable coronary artery disease. (
  • Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. (
  • Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease (CLARIFY) Investigators. (
  • Coronary Artery Disease: Should I Have Bypass Surgery? (
  • Have coronary artery bypass surgery along with medical therapy (lifestyle changes and medicines). (
  • Don't have coronary artery bypass surgery. (
  • What is coronary artery bypass surgery? (
  • Bypass surgery-also called coronary artery bypass graft surgery-helps improve blood flow to the heart in people with severe coronary artery disease . (
  • Bypass surgery is not a cure for heart disease. (
  • Coronary bypass surgery redirects blood around a section of blocked or partially blocked arteries in your heart to improve blood flow to your heart muscle. (
  • Aortic replacement combined with coronary bypass surgery has an impact on the risk profile for the direct postoperative course and also on the long-time survival perspective. (
  • Have a known history of heart disease (such as heart attack, bypass surgery or stent). (
  • Any history of coronary artery bypass surgery, coronary artery stenting, or clinical diagnosis of coronary artery disease according to the electronic medical record. (
  • The diagnosis of coronary artery disease should not limit your return to health, nor give you anxiety if well managed. (
  • Both western and TCM treatments for coronary artery disease, common side-effects associated with prescription drug treatments, and an herbal alternative treatment will be discussed in the article. (
  • Centers for Disease Control and Prevention. (
  • I'm Commander Ibad Khan, and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (
  • But there's plenty you can do to prevent and treat coronary artery disease. (
  • Be familiar with herbal prescriptions used to treat coronary artery disease. (
  • What causes coronary artery disease? (
  • The right coronary artery and the left coronary artery, which branch off the aorta just after it leaves the heart, deliver oxygen-rich blood to the heart muscle. (
  • In addition the reduction in aortic compliance may result in a decrease in diastolic coronary perfusion, as this is dependent on the recoil of the aorta which has been stretched during systole. (
  • Angiographic study revealed that 10 (1%) had left main coronary disease, 747 (68%) patients had single vessel disease, 181 (17%) had two-vessel disease and that 155 (14%) had three-vessel disease. (
  • The surgeon connects, or grafts, a healthy blood vessel from another part of your body to the narrowed coronary artery. (
  • The grafted blood vessel goes around (bypasses) the narrowed part of the artery. (
  • Resistive vessel function in coronary artery disease. (
  • The procedure involves taking a healthy blood vessel from your leg, arm or chest, and connecting it beyond the blocked arteries in your heart. (
  • The risk continued to rise with obstructive disease, so that people with obstructive 3-vessel or left main disease had nearly 20 times the risk for MI. (
  • 50% in any coronary artery segment (vessel score) had approximately twofold higher odds of early AMD, OR 1.95 (95% CI 1.07 to 3.57). (
  • Electroconvulsive therapy in a patient with left main and triple vessel Coronary Artery Disease (CAD): Anaesthetic management. (
  • A growing number of people are currently suffering from a range of major clinical heart and circulatory disease conditions, including coronary artery disease (CAD), heart failure, peripheral arterial disease, and cerebrovascular disease [ 1 ]. (
  • CAD can also lead to other health problems, most commonly heart attacks, heart rhythm problems like atrial fibrillation, and heart failure (cardiac insufficiency).Some people who have Coronary Artery Disease develop depression too. (
  • Multidisciplinary decision-making should analyze current evidence, consider the clinical condition of the patient, and determine the safety of and necessity for coronary revascularization with either PCI or CABG. (
  • All patients had been referred for a PET myocardial perfusion scan due to a clinical history of coronary disease. (
  • Due to the proinflammatory effects and various studies, which had illustrated that the Lp-PLA2 was correlated with a wide range of cardiovascular diseases [ 9 - 11 ], Lp-PLA2 is gradually identified as a reliable biomarker for the risk of clinical cardiovascular events. (
  • In order to achieve optimal treatment results for coronary artery disease with minimal side effects and adverse reaction/interactions, this course will help practitioners identify the western and TCM diagnosis for coronary artery disease and its chief clinical manifestations. (
  • The assessment part of the report embraces, in depth Coronary Artery Disease commercial assessment and clinical assessment of the pipeline products under development. (
  • In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Coronary Artery Disease collaborations, licensing, mergers and acquisition, funding, designations and other product related details. (
  • This segment of the Coronary Artery Disease report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. (
  • Despite the increased level of risk associated with nonobstructive disease, the major prevention studies have only included patients who had had clinical events or who had obstructive CAD. (
  • In procedures where the aortic valve replacement (AVR) is combined with a coronary artery bypass graft (CABG), the use of a rapid deployment valve can shorten the duration of cardiac ischemia and the overall intervention duration, which possibly has an influence on clinical results. (
  • Several clinical parameters are associated with common diseases and are helpful for predicting and preventing these common diseases. (
  • [ 2 ] ), and heart disease continues to be the leading cause of death for women in the United States, accounting for more deaths in women than all forms of cancer, chronic lower respiratory disease, and diabetes mellitus combined. (
  • She has no history of coronary artery disease, diabetes mellitus, or pulmonary disease. (
  • IMSEAR at SEARO: Diet and coronary artery disease. (
  • IMSEAR at SEARO: Coronary artery disease in women. (
  • Coronary artery bypass grafting (CABG) is the most effective revascularization approach for stenotic coronary arteries. (
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (
  • The right coronary artery branches into the marginal artery and the posterior interventricular artery, located on the back surface of the heart. (
  • A drug-eluting stent was placed in the mid-left anterior descending artery. (
  • The stent props the artery open, decreasing its chance of narrowing again. (
  • Guthrie Cardiac and Vascular team treats patients with circulatory diseases: abdominal aortic aneurysm, carotid artery disease, and peripheral artery disease. (
  • A study by Pande et al suggests millions of US adults with peripheral arterial disease (PAD) are not receiving secondary prevention therapies. (
  • Shared variables in these two impressive models include age, previous MI, peripheral vascular disease (PVD), renal failure, hemodynamic state and EF. (
  • It commonly occurs in the peripheral arteries of the lower limbs in otherwise healthy elderly patients (Monckeberg's sclerosis), where it is seen as "rail tracking" on plain radiographs. (
  • These patients must be amenable to and qualify for coronary revascularization and have undergone noninvasive testing, excluding stress tests indicating a high likelihood of severe IHD. (
  • Coronary revascularization is the most important treatment strategy for CAD. (
  • Patients who will experience little benefit from coronary revascularization are also excluded. (
  • In fact, the previously published research had revealed that the ratio of apoB/apoA-1 appeared to be more significantly associated with the extent of coronary artery lesions in Chinese diabetics [ 14 ]. (
  • Guthrie Robert Packer Hospital was named among the top 10% in the nation for coronary interventional procedures for 5 years in a row (2016-2020) by Healthgrades. (
  • We also report on ongoing trials focusing on interventional strategies to optimize the long-term management of coronary patients. (
  • The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. (
  • 5 The mechanism linking diagonal earlobe creases and atherosclerotic disease is not yet clear. (
  • Taken together, these studies support the idea that the activation of the MEF2 genes confers protection against the atherosclerotic degeneration of the arteries' walls. (
  • Due to epidemiology, we have been able to identify the determinants and the aggravating factors of heart diseases or risk factors for cardiovascular diseases, such as coronary artery disease, and their mechanism of action. (
  • This supplement to The American Journal of Cardiology presents the proceedings of the Summit on Cholesterol and Coronary Disease: Second National Conference on Lipids in the Elimination and Prevention of Coronary Artery Disease presented by the Cleveland Clinic Foundation in cooperation with the Walt Disney Company in Lake Buena Vista, Florida, September 4-5, 1997. (
  • Women are more likely than men to have health conditions or life situations that up their risk for coronary artery disease. (
  • This article is intended for clinicians who want to maintain a current understanding of recent research and evidence in decision making for predicting cardiovascular events in patients at risk for coronary events. (
  • Describe the relevance of the findings to clinicians in the care of their patients at risk for coronary events. (
  • A number of risk factors contribute to the development of coronary artery disease. (
  • Primordial prevention usually refers to healthy lifestyle choices to prevent the development of coronary risk factors. (
  • A coronary calcium score of 0 is associated with an annual MI rate of 20% annual rate of MI. (
  • They are not that the benefits of cost-lowering the blood circulation of these medications and allow a calcium intake to the body herbs to lower blood pressure Dr. Axe to reduce the risk of diabetes, or kidney disease. (
  • Inform clinicians of the latest medical information on the value of adding the coronary calcium score to risk stratification for predicting coronary disease risk during 5 years in persons without prior coronary disease, as reported at the American College of Cardiology 58th Annual Scientific Session. (
  • Narrowed arteries can cause chest pain because they can block blood flow to your heart muscle and the rest of your body. (
  • Most heart attacks are caused by a blood clot that blocks one of the coronary arteries. (