Coronary Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Aneurysm: Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Coronary Vessels: The veins and arteries of the HEART.Aneurysm, Infected: Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Fractional Flow Reserve, Myocardial: The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.Heart Aneurysm: A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Ultrasonography, Interventional: The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Coronary Stenosis: Narrowing or constriction of a coronary artery.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Iliac Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.Embolization, Therapeutic: A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Fistula: Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.Pulse Therapy, Drug: Administration of high doses of pharmaceuticals over short periods of time.Arterio-Arterial Fistula: Abnormal communication between two ARTERIES that may result from injury or occur as a congenital abnormality.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Vascular Fistula: An abnormal passage between two or more BLOOD VESSELS, between ARTERIES; VEINS; or between an artery and a vein.Extracorporeal Circulation: Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Coronary Artery Bypass, Off-Pump: Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).

Autologous vein-coated stent for exclusion of a coronary artery aneurysm: case report with postimplantation intravascular ultrasound characteristics. (1/370)

This report describes the successful use of an autologous cephalic vein-coated coronary stent to exclude an aneurysm of the distal right coronary artery. Post-implantation angiography confirmed successful exclusion of the aneurysm with no evidence of leakage. Intravascular ultrasonography showed complete apposition of the stent to the arterial wall proximal and distal to the aneurysm. The vein could be seen clearly around the stent. Symmetrical stent expansion (minimal luminal diameter, 2.8 mm) was verified. Increased echogenicity in the excluded aneurysm indicated early thrombus formation. Evidently, this is the 1st report of the successful use of an autologous cephalic vein-coated coronary stent to exclude an aneurysm of the distal right coronary artery.  (+info)

Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms ("dilated coronopathy"). (2/370)

OBJECTIVES: The purpose of our study was to evaluate the clinical significance of isolated coronary artery ectasias or aneurysms (CEA). BACKGROUND: It has been postulated that altered coronary blood flow in CEA predisposes patients to the development of myocardial ischemia (CI) and infarction. METHODS: Sixty-seven patients with bilateral nonobstructive CEA without associated cardiac defects ("dilated coronaropathy") were derived from 16,341 cardiac catheterizations between 1986 and 1997. Ectasias were defined as luminal dilation of 1.5- to 2.0-fold, aneurysms of >2.0-fold of normal limits. Eleven of 25 patients presented with myocardial infarction due to an occlusion of the infarct vessel. In 42 patients without infarction (study group), exercise-induced CI was investigated. RESULTS: A corresponding CI was documented in 32 of 42 patients in a coronary sinus lactate study (reduced lactate extraction 5.6 +/- 4.1%) and in 29 of 40 patients in an ergometry (0.25 +/- 0.06 mV ST depressions). The results differed significantly from a control group of 29 patients without heart disease (p < 0.001). Nitroglycerin (0.8 mg) provoked a further significant deterioration of CI in the 32 of 42 developing a frank cardiac lactate production (-2.6 +/- 6.8%, p < 0.001). The metabolic extent of CI was significantly correlated to the coronary diameters of the proximal and middle segments of left anterior descending artery and the middle segment of left circumflex artery (r = 0.87, p < 0.001). Stigmata of an impaired coronary blood flow such as delayed antegrade filling, segmental backflow phenomenon and local deposition of dye were found significantly more often with increasing coronary diameters (p < 0.04). CONCLUSIONS: "Dilated coronaropathy" is an entity of nonobstructive, ischemic coronary artery disease. Nitroglycerin is of no therapeutic benefit but leads to an aggravation of exercise-induced CI.  (+info)

Kawasaki disease: a maturational defect in immune responsiveness. (3/370)

Kawasaki disease (KD), an acute febrile disease in children of unknown etiology, is characterized by a vasculitis that may result in coronary artery aneurysms (CAAs). In new patients with KD, a selective and prolonged T cell unresponsiveness to activation via the T cell antigen receptor CD3 was observed, whereas proliferation to other stimuli was intact. This "split T cell anergy" delineated KD from other pediatric infections and autoimmune diseases and correlated with CAA formation (P<.001). A transient immune dysfunction was also suggested by an incomplete responsiveness to measles-mumps-rubella (MMR) vaccination in patients with KD versus controls (P<.0001; odds ratio, 15.6; 95% confidence interval, 4.8-51.1), which was overcome by revaccination(s). The reduced responsiveness to MMR in patients with KD suggests a subtle and predetermining immune dysfunction. An inherent immaturity to clear certain antigens may be an important cause that precipitates KD and the immune dysregulation during acute disease.  (+info)

Transthoracic echocardiography using second harmonic imaging: diagnostic alternative to transesophageal echocardiography for the detection of atrial right to left shunt in patients with cerebral embolic events. (4/370)

OBJECTIVES: We sought to evaluate whether transthoracic contrast echocardiography using second harmonic imaging (SHI) is a diagnostic alternative to transesophageal contrast echocardiography (TEE) for the detection of atrial right to left shunt. BACKGROUND: Paradoxic embolism is considered to be the major cause of cerebral ischemic events in young patients. Contrast echocardiography using TEE has proven to be superior to transthoracic echocardiography (TTE) for the detection of atrial shunting, SHI is a new imaging modality that enhances the visualization of echocardiographic contrast agents. METHODS: We evaluated 111 patients with an ischemic cerebral embolic event for the presence of atrial right to left shunt using an intravenous (IV) contrast agent in combination with three different echocardiographic imaging modalities: 1) TTE using fundamental imaging (FI); 2) TTE using SHI; and 3) TEE. The severity of atrial shunting and the duration of contrast visibility within the left heart chambers were evaluated for each imaging modality. Image quality was assessed separately for each modality by semiquantitative scoring (0 = poor to 3 = excellent). Presence of atrial right to left shunt was defined as detection of contrast bubbles in the left atrium within the first three cardiac cycles after contrast appearance in the right atrium either spontaneously or after the Valsalva maneuver. RESULTS: A total of 57 patients showed evidence of atrial right to left shunt with either imaging modality. Fifty-one studies were positive with TEE, 52 studies were positive with SHI, and 32 were positive with FI (p<0.001 for FI vs. SHI and TEE). The severity of contrast passage was significantly larger using SHI (61.6+/-80.2 bubbles) compared to FI (53.7+/-69.6 bubbles; p<0.005 vs. SHI) but was not different compared to TEE (43.9+/-54.3 bubbles; p = NS vs. SHI). The duration of contrast visibility was significantly longer for SHI (17.4+/-12.4 s) compared to FI (13.1+/-9.7 s; p<0.001) and TEE (11.9+/-9.6 s; p<0.02). Mean image quality improved significantly from FI (1.5+/-0.8) to SHI (2.0+/-0.8; p<0.001 vs. FI) and TEE (2.5+/-0.7; p<0.001 vs. SHI). CONCLUSIONS: In combination with IV contrast injections, TEE and SHI have a comparable yield for the detection of atrial right to left shunt. Both modalities may miss patients with atrial shunting. In young patients with an unexplained cerebrovascular event and no clinical evidence of cardiac disease, a positive SHI study may obviate the need to perform a TEE study to search for cardiac sources of emboli.  (+info)

The impact of untreated coronary dissections on acute and long-term outcome after intravascular ultrasound guided PTCA. (5/370)

AIM: Vessel size adapted PTCA results in the use of larger balloons with an increased incidence of severe vascular dissections. The aim of our trial was (a) to evaluate the effect of severe dissections on the acute outcome and (b) to study the natural history of dissections after 1 year. METHODS AND RESULTS: One hundred and seventy-eight patients with 195 lesions underwent vessel size adapted PTCA using intravascular ultrasound. Clinical and angiographic 1 year follow-up was obtained for all patients. Intravascular ultrasound was performed before PTCA to measure the external elastic membrane diameter at the lesion site so that the balloon size could be adopted (external elastic membrane-10%) and post-interventionally to determine the procedural success and the incidence of intracoronary dissections. Stent implantation was reduced to persistently flow limiting dissections (TIMI I, II). Dissections were detected by intravascular ultrasound in 128/195 (66%) lesions (by angiography in 111/195 [58%] lesions) and classified by intravascular ultrasound criteria into four groups: group I: no dissection (67 lesions [34%]), group II: mild dissections (21 lesions [11%]), group III: medium dissections (19 lesions [10%]) and group IV: severe dissections (88 lesions [45%]). Because of threatened vessel closure, GPIIb/IIIa antagonists were used in eight (4.5%) patients and a stent was implanted in two (1. 1%) patients. The cumulative event rate after 1 year was 12% and the global angiographic restenosis rate was 19%. The post-interventional evidence of severe dissections was associated with a decrease in clinical events during long-term follow up (group I: 13 events [19%] vs group IV: seven events [7%];P=0.03). This was also true for the occurrence of restenosis which was significantly lower in patients with severe dissections (group I: 19 [28%] lesions vs group IV:10 [11%] lesions;P=0.01). CONCLUSIONS: According to the theory of 'therapeutic dissections', our data suggest that substantial dissections following PTCA, which do not diminish antegrade blood flow, do not lead to an increase in acute or long-term events. The natural history of vessel injury seems to provide favourable wound healing without increase of restenosis. Thus, stenting for treatment of large dissections without flow limitation does not seem to be mandatory.  (+info)

Greater late lumen loss after successful coronary balloon angioplasty in the proximal left anterior descending coronary artery is not explained by extent of vessel wall damage or plaque burden. (6/370)

OBJECTIVES: We investigated whether the greater late lumen loss after coronary balloon angioplasty in the proximal left anterior descending artery (P-LAD) compared with that in other segments might be related to differences in vascular dimensions or morphology as determined by angiography and intravascular ultrasound imaging. BACKGROUND: The greater late lumen loss after angioplasty in the P-LAD that has been observed in several studies has not been explained. METHODS: We studied 178 patients and 194 coronary artery lesions by quantitative angiography and 30 MHz intravascular ultrasound imaging after successful balloon angioplasty. Vessel wall morphology was compared among three proximal and three nonproximal segments. Follow-up quantitative angiography for late lumen loss calculation was performed in 168 lesions. Multivariate analysis was used to determine predictors of late lumen loss. RESULTS: Absolute and relative late loss were significantly greater at the P-LAD compared with the pooled group of other segments (0.42 +/- 0.60 mm vs. 0.10 +/- 0.48 mm, p = 0.0008 and 0.14 +/- 0.24 vs. 0.03 +/- 0.17, p < 0.001). Also, a greater percentage of calcific lesions (65% vs. 44%, p = 0.034), a lower incidence of rupture (51% vs. 74%, p = 0.009) and a larger reference segment plaque area (5.4 +/- 2.2 mm2 vs. 4.7 +/- 1.9 mm2, p = 0.05) were found in the P-LAD. In multivariate analysis however, these variables were not predictive of late loss. CONCLUSIONS: Greater late lumen loss after coronary balloon angioplasty of the P-LAD is not explained by differences in atherosclerotic plaque burden or in vessel wall damage.  (+info)

Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function. (7/370)

OBJECTIVES: To investigate the long term consequences of regressed aneurysms after Kawasaki disease, using follow up coronary angiography; to assess the vascular wall morphology at the site of the aneurysms by intravascular ultrasound imaging; and to evaluate the function of the affected vessels using intracoronary infusions of acetylcholine and isosorbide dinitrate. DESIGN: 33 patients were studied, 27 with previous Kawasaki disease and six with congenital heart disease. All Kawasaki disease patients were followed for more than 10 years from disease onset. The 33 patients comprised four groups: group 1 included 13 Kawasaki disease patients with a total of 23 sites of regressed large sized (>/= 4 mm) coronary aneurysms; group 2 included 13 Kawasaki disease patients with 22 sites of regressed small sized (< 4 mm) coronary aneurysms (four patients had sites of both large and small sized aneurysms); group 3 included a further five Kawasaki disease patients with 25 normal coronary angiography sites in the acute stage of Kawasaki disease; and group 4 comprised the six patients with congenital heart disease as controls, with a total of 27 normal coronary angiography sites. During coronary angiography, 15 microg of acetylcholine and 0.5 mg isosorbide dinitrate were infused into the coronary artery. The luminal diameter at the sites was measured using a cine-videodensitometric analyser, to assess the distensibility of the coronary artery wall. RESULTS: Coronary angiography in all 22 patients in groups 1 and 2 and in all the patients in group 3 was normal, with no stenoses and no irregularity of the arterial wall. However, the intravascular ultrasound imaging in groups 1 and 2 showed various degrees of the intimal thickening. In groups 1 and 2, there was significantly more vascular constriction with acetylcholine, and poorer dilatation with isosorbide dinitrate than in groups 3 or 4 (each p < 0.05, respectively). There was no difference between group 3 and group 4 in response to either acetylcholine or isosorbide dinitrate, CONCLUSIONS: There is evidence of persisting abnormal vascular wall morphology and vascular dysfunction at the site of regressed coronary aneurysms in patients with previous Kawasaki disease. These patients should be counselled to avoid potential risk factors for atherosclerosis, and long term follow up is needed into adult life.  (+info)

Outcome from balloon induced coronary artery dissection after intracoronary beta radiation. (8/370)

OBJECTIVE: To evaluate the healing of balloon induced coronary artery dissection in individuals who have received beta radiation treatment and to propose a new intravascular ultrasound (IVUS) dissection score to facilitate the comparison of dissection through time. DESIGN: Retrospective study. SETTING: Tertiary referral centre. PATIENTS: 31 patients with stable angina pectoris, enrolled in the beta energy restenosis trial (BERT-1.5), were included. After excluding those who underwent stent implantation, the evaluable population was 22 patients. INTERVENTIONS: Balloon angioplasty and intracoronary radiation followed by quantitative coronary angiography (QCA) and IVUS. Repeat QCA and IVUS were performed at six month follow up. MAIN OUTCOME MEASURES: QCA and IVUS evidence of healing of dissection. Dissection classification for angiography was by the National Heart Lung Blood Institute scale. IVUS proven dissection was defined as partial or complete. The following IVUS defined characteristics of dissection were described in the affected coronary segments: length, depth, arc circumference, presence of flap, and dissection score. Dissection was defined as healed when all features of dissection had resolved. The calculated dose of radiation received by the dissected area in those with healed versus non-healed dissection was also compared. RESULTS: Angiography (type A = 5, B = 7, C = 4) and IVUS proven (partial = 12, complete = 4) dissections were seen in 16 patients following intervention. At six month follow up, six and eight unhealed dissections were seen by angiography (A = 2, B = 4) and IVUS (partial = 7, complete = 1), respectively. The mean IVUS dissection score was 5.2 (range 3-8) following the procedure, and 4.6 (range 3-7) at follow up. No correlation was found between the dose prescribed in the treated area and the presence of unhealed dissection. No change in anginal status was seen despite the presence of unhealed dissection. CONCLUSION: beta radiation appears to alter the normal healing process, resulting in unhealed dissection in certain individuals. In view of the delayed and abnormal healing observed, long term follow up is indicated given the possible late adverse effects of radiation. Although in this cohort no increase in cardiac events following coronary dissections was seen, larger populations are needed to confirm this phenomenon. Stenting of all coronary dissections may be warranted in patients scheduled for brachytherapy after balloon angioplasty.  (+info)

Background: Children with giant coronary artery aneurysms (CAA) after Kawasaki disease (KD) are at substantial risk of thrombosis. There are currently no evidence-based guidelines for optimal thromboprophylactic therapy in these children.. Methods: The North American Kawasaki Disease Registry was queried to identify all patients with giant CAA (maximum coronary artery z-score ,10) and their antithrombotic therapy. Freedom from thrombosis was modelled using the Kaplan-Meier method; thrombotic complication rate was calculated per patient-year/month of follow-up.. Results: n=202 patients with giant CAA were included, of whom 28 (14%) experienced either coronary artery thrombosis with or without myocardial infarction. Freedom from thrombotic complications was 92%, 85% and 79% at 3 months, 5 and 10 years after diagnosis, respectively. Non-pharmacological factors associated with increased risk of thrombotic complications included higher maximum coronary artery z-scores (HR: 1.7/+10 SD, p,0.001), ...
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and sudden cardiac death with high predilection for premenopausal women. The overall incidence of SCAD in patients referred for coronary angiography has been reported to vary between 0.1% and 1%. In a series of 94 antemortem and postmortem cases the mean age for men was 46 years and the mean age for women was 39 years. In this series, the dissection of right coronary artery was more common in men while the left coronary artery system was most commonly affected in women. Although the precise etiology of SCAD remains unclear, several risk factors such as atherosclerosis, connective tissue disorder, peri-partum episode, and trauma have been postulated. Consequently, SCAD could result in a wide spectrum of presentations ranging from chest pain to extensive myocardial infarction. Notably, sudden cardiac death has been a common mode of clinical presentation in many previously reported cases. While the definitive diagnosis
Study Start Date: April 2014. Spontaneous Coronary Artery Dissection (SCAD) is an unpredictable event in which patients typically first present with a sudden, unexpected heart attack. The condition can affect all age groups and is recognised as a cause of heart attacks in young adults. Although both men and women can be affected by SCAD, the condition is more common in women, particularly during or shortly after pregnancy.. SCAD results from an acute bleed into the vessel wall of a coronary artery creating a false lumen (a lumen is the term for the inside of a blood vessel, the tube down which the blood is supposed to flow). This accumulation of blood compresses the true lumen, restricting or preventing blood flow to the heart muscle. Little is currently known about the underlying causes of SCAD and its long-term outcomes, or indeed, how best to treat it. (Picture below shows angiographs of vessel before (A) and after (B) stenting.). ...
Long term objective:Discover molecular and cellular mechanisms of SCAD and develop biomarkers to enable prediction and prevention.. The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause tears in blood vessels that supply the heart. Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person. The study includes individuals diagnosed with spontaneous coronary artery dissection and their biological parents.. Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement. ...
Spontaneous coronary artery dissection (SCAD) is a rare myocardial ischemic disease that threatens patients life. Various risk factors are associated with SCAD, such as smoking, severe hypertension and psychological reasons.
Spontaneous coronary artery dissection (SCAD) occurs when blood flow in the heart slows or stops because of a tear in the wall of an artery. Read about SCAD symptoms, causes and treatment, and hear from people who have experienced it.
Spontaneous Coronary Artery Dissection (SCAD) - a rare condition that can cause a heart attack. Learn more about the causes, symptoms, diagnosis and treatment from the number one heart center, Cleveland Clinic.
Find media articles, news releases and videos about the Spontaneous Coronary Artery Dissection (SCAD) Research Program at Mayo Clinic.
Many patients who experience a type of heart attack known as spontaneous coronary artery dissection may benefit most from a conservative approach to treatment, rather than more invasive procedures. A scientific statement reviewing current knowledge and best practices for SCAD treatment - put together by a collaborative working group from multiple institutions including Massachusetts General Hospital - was published today in the American Heart Association journal, Circulation.
TY - JOUR. T1 - Exertional dyspnoea due to spontaneous coronary artery dissection in a 55-year-old man. AU - Iturbe, J. M.. AU - Banerjee, S.. AU - Brilakis, E. S.. PY - 2007/10/1. Y1 - 2007/10/1. UR - http://www.scopus.com/inward/record.url?scp=34848874515&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=34848874515&partnerID=8YFLogxK. U2 - 10.1136/hrt.2006.100982. DO - 10.1136/hrt.2006.100982. M3 - Article. C2 - 17890697. AN - SCOPUS:34848874515. VL - 93. JO - Heart. JF - Heart. SN - 1355-6037. IS - 10. ER - ...
Coronary artery aneurysm is an abnormal dilatation of part of the coronary artery. Acquired causes include atherosclerosis, Kawasaki disease and coronary catheterization. It can also be congenital. It is often found coincidentally on coronary angiography. Generally, it has a good prognosis. In Kawasakis disease, untreated, there is a 1-2% death rate, from cardiac causes. Nichols L, Lagana S, Parwani A (May 2008). "Coronary artery aneurysm: a review and hypothesis regarding etiology". Arch. Pathol. Lab. Med. 132 (5): 823-8. doi:10.1043/1543-2165(2008)132[823:CAAARA]2.0.CO;2. PMID 18466032. Fukazawa R, Ikegam E, Watanabe M, et al. (May 2007). "Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence". Circ. J. 71 (5): 709-15. doi:10.1253/circj.71.709. PMID 17456996. Archived from the original (- Scholar search) on 2012-12-19. Seabra-Gomes R, Somerville J, Ross DN, Emanuel R, Parker DJ, Wong M (April 1974). "Congenital coronary artery aneurysms". Br Heart ...
Background: Drug-eluting stents (DES) may induce toxic effects on the coronary arterial wall such as aneurysm formation, incomplete stent apposition, stent thrombosis and vessel rupture based on the experimental studies. We investigated the incidence and characteristics of arteriopathy at 6 month routine angiographic follow up after DES implantation regardless of clinical events in a single center unrestricted DES registry.. Methods: A total 614 consecutive patients (pts, Male 278, mean age 63.12±10.89 years) who were treated with DES (Sirolimus-SES and/or Paclitaxel-PES) were enrolled. We performed routine angiographic follow up at 6 months regardless of clinical events and IVUS was done in case of angiographic aneurismal change at the DES implanted site was observed.. Results: Conventional coronary risk factors were not different compared with control study population. The incidence of coronary aneurysm was 3.1 % (19/614). Among the 19 coronary aneurysm patients (pts, Male 16, Age 61.68± ...
We present our recent casuistry on such an interesting issue as coronary dissections. Provide data to assist the diagnosis and treatment of this disease.
Who gets it?. Typically, it affects women below the age of 50 years of age. Women outnumber men by a ratio of 9:1. SCAD is considered a rare cause of heart attacks. It probably is responsible for about 4% of all heart attacks. In women aged 50 or less it probably accounts of 25-35% of all heart attacks. The proportion is even higher in pregnant women.. Why does it happen?. We dont know for sure. It is believed that especially in pregnancy, hormonal changes (in the third trimester and during childbirth and even in the immediate period after delivery can make the arterial walls more vulnerable and weak. What we dont know for sure is whether it is just about the pregnancy or whether the patient themselves have an underlying propensity to start off with. What we do know is that people with very tortuous coronary arteries seem to be more predisposed to SCAD.. Several conditions can cause an underlying propensity to a weaker coronary artery walls.. These include:. 1) Fibromuscular dysplasia (about ...
SCAD is an uncommon cardiac event that occurs when a tear forms in one or more of the coronary arteries near the heart. Find out more & meet survivors here.
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There was a record 245+ registered participants including 35 survivors who came from across the US and a survivor from Canada. Over $35,000 was raised for research. Participants enjoyed a warm up led by Michelle Short from the Oceanside Jazzercise Center. Matt Baylow, meteorologist from CBS News 8 San Diego was our emcee and reminded everyone to wear sunscreen even though it was overcast. Prior to the start of the 5K, survivors were acknowledged by the rest of the participants. As participants crossed the finish line they received a participation medal and enjoyed a complimentary lunch plus other refreshments. There was a silent auction as well as booths with information from various sponsors and supporters. A special thank you to survivors Raylene Davis, Ellen Robin (committee lead), Karin Kiefer, Erin Balogh, Marti Snyder, Tanya Gray, Wini Simon, Caroline Knaplund, who spent many hours planning this very successful event.. SCADaddle for Research SCADaddle for Research West Coast Sponsors were ...
A 41-year-old Caucasian female with a history of hypertension presented with exertional chest pain. Her vital signs were stable on admission and physical examination was unremarkable. An Electrocardiogram (EKG) revealed inferior ST segment elevations consistent with acute myocardial infarction and cardiac enzymes were elevated. She was started on heparin, and underwent immediate cardiac catheterization.
Case Reports in Cardiology is a peer-reviewed, Open Access journal that publishes case reports related to hypertension, arrhythmia, congestive heart failure, valvular heart disease, vascular disease, congenital heart disease and cardiomyopathy.
Kawasaki disease is an acute febrile illness that usually occurs in children younger than 5 years of age. The use of intravenous immunoglobulin (IVIG) within the first 10 days of illness has been shown to reduce the incidence of coronary artery aneurysms significantly. The relative roles of repeated doses of intravenous immunoglobulin (IVIG) are controversial in refractory Kawasaki disease (KD). Most experts recommend the second retreatment with IVIG, 2 g/kg in refractory KD. However, the dose-response effect of the third or fourth IVIG was uncertain. Although there have been a significant number of reports on new therapeutic options for refractory KD, such as steroid, infliximab, methotrexate, and other immunosuppressants, their effectiveness in reducing the prevalence of coronary artery aneurysms was unproven. We present here KD patient with small coronary artery aneurysm who is resistant to the third IVIG and steroid pulse therapy but showed improvement immediately after the infusion of the
Aneurysmal coronary artery disease is characterised by abnormal dilatation of a localised or diffuse segment of the coronary artery tree. Before the advent of coronary angiography, all reported cases were based on postmortem findings. The largest angiographic series is the Coronary artery surgery study (CASS) registry where 4.9% of 20 087 patients were observed at angiography to have coronary artery aneurysms.1 In this series, a coronary artery aneurysm was defined as a dilatation with a diameter of ⩾ 1.5 times the adjacent normal coronary artery. Ninety per cent of these were associated with atherosclerotic coronary artery disease, where vessel ectasia and poststenotic dilatations are not an infrequent finding. Tunick et al in their series,2 used the term "discrete aneurysm" to mean a localised spherical or saccular shaped dilatation of ⩾ 1.5 times. They excluded fusiform aneurysms as they felt that these may be confused with vessel ectasia. In their series of 8422 patients an incidence of ...
Spontaneous coronary artery dissection (SCAD) is a rare but often fatal cause of ischaemic heart disease occurring predominantly in young or middle aged, otherwise healthy subjects. Although about 250 cases of SCAD have been reported in the literature, to the best of our knowledge, spontaneous three vessel coronary dissection associated with typical effort angina has never been reported. This case illustrates coronary angiography and intravascular ultrasound images in a patient with SCAD involving all three vessels and treated by stenting.. A 57 year old man presented with exertional chest pain. His risk factors included smoking, hypertension, and hyperlipidaemia. ECG showed an abnormal Q wave in lead III and 1 mm ST depression in III, aVF. Technetium-99m sestamibi SPECT image showed a moderate fixed defect in the inferior wall and a reversible defect in the anterior wall. Selective coronary angiography revealed SCAD involving all three vessels. Right coronary angiogram showed linear dissection ...
In adults, CAA is predominantly atherosclerotic in origin however, other causes include Kawasaki disease, autoimmune disease, trauma, infection, dissection, congenital malformation and angioplasty [1, 24]. Recently, with the advent of implantation of drug eluting stents there are increasing reports suggesting stents causing coronary aneurysm months or years after the procedure [1, 14, 22, 24]. The proposed pathogenesis of stent-related aneurysm formation is multi-factorial. The drug-eluting stent contains immunosuppressant such as Sirolimus, which inhibits inflammation, or chemotherapeutic agents like Paclitaxel, which is an anti-inflammatory agent and inhibits cell proliferation. In due course of time, once drug is eluted, the polymer in which the drug is embedded may elicit a hypersensitivity reaction and vasculitis and results in weakening of vessel wall and subsequent dilatation [1, 14, 22, 24]. Mechanical damage to the arterial wall during balloon angioplasty and stent placement or ...
Fingerprint Dive into the research topics of Nationwide survey of coronary aneurysms with diameter ,6 mm in Kawasaki disease in Korea. Together they form a unique fingerprint. ...
Ischemic heart disease (IHD) may coexist with aorto-iliac occlusive disease, and concomitant revascularization procedures may be required. This study reports our experience with ascending aorta to left femoral bypass grafting (Ao-ltFG) to prepare for intra-aortic balloon pumping (IABP). A 73-year-old man with chest pain was admitted to our hospital. Coronary angiography revealed coronary aneurysm and IHD. Enhanced computed tomography showed coronary aneurysm, complete left subclavian artery occlusion and bilateral external iliac artery occlusion. We planned a two-stage operation. In the first operation, we chose coronary artery bypass grafting, excision of the coronary aneurysm and simultaneously Ao-ltFG to prepare for IABP. In the second operation, we chose axillo-axillo bypass grafting and Ao-ltFG to right femoral artery bypass grafting. Although in the operative findings no coronary aneurysm was recognized, we performed the other operations and the postoperative course was uneventful without ...
Spontaneous coronary artery dissection (SCAD) which was first described by Pretty in 1931 is rare but significant cause of myocardial infarction and sudden cardiac death. The incidence of this condition in general population is between 0.28% and 1.1%, however in pregnant population it accounts for 27% of all MI cases.1 Mode of presentation is variable and can range from asymptomatic pathology to MI and sudden cardiac death. In the past, sudden cardiac death was the most common presentation with 70% of diagnoses was made at the time of autopsy. 36 years old G3P1+1 at 38 weeks of gestation admitted to delivery suite with spontaneous labour and delivered a live male baby. Two hours after delivery, she started complaining of central chest pain which was radiating to back and left arm along with vomiting. She was haemodynamically stable with normal oxygen saturation. Immediate blood gases, chest x-ray and troponin levels were all normal. However ECG demonstrated inferior ST segment elevation. A Tran ...
TY - JOUR. T1 - Eosinophilic arteritis with coronary aneurysms and stenoses. AU - Poommipanit, Paul B.. AU - Lensky, Mark. AU - Tobis, Jonathan. PY - 2005/5/1. Y1 - 2005/5/1. UR - http://www.scopus.com/inward/record.url?scp=18244375810&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=18244375810&partnerID=8YFLogxK. M3 - Article. C2 - 15879607. AN - SCOPUS:18244375810. VL - 17. SP - 266. EP - 269. JO - Journal of Invasive Cardiology. JF - Journal of Invasive Cardiology. SN - 1042-3931. IS - 5. ER - ...
TIRADO, Gabriel I et al. Utilization of Two Internal Thoracic Arteries in a 9 Year-old Boy with Kawasaki Disease. Rev. argent. cardiol. [online]. 2008, vol.76, n.1, pp.64-66. ISSN 1850-3748.. Kawasaki disease is an acute febrile condition affecting children. Morbidity and mortality are related with the existence of coronary aneurysms. This case report is about a 9 year-old boy presenting with a diagnosis of giant main left coronary artery aneurysm and multiple median aneurysms of the right coronary artery. The boy underwent coronary artery by pass surgery graft with two internal thoracic arteries. After 60 months of follow-up, the patient was free of symptoms and the current myocardial perfusion SPECT was negative for ischemia at rest or during exercise. Sternal and thoracic growth has been normal.. Palabras clave : Kawasaki Disease; Coronary Aneurysm; Surgery; Coronary Vessels. ...
Background-Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which are important features of Kawasaki disease (KD). We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome. Methods and Results - We investigated genetic variation in 15 genes belonging to the TGF-β pathway in a total of 771 KD subjects of mainly European descent from the United States, the United Kingdom, Australia, and the Netherlands. We analyzed transcript abundance patterns using microarray and reverse transcriptase-polymerase chain reaction for these same genes, and measured TGF-β2 protein levels in plasma. Genetic variants in TGFB2, TGFBR2, and SMAD3 and their haplotypes were consistently and reproducibly associated with KD susceptability, coronary artery aneurysm formation, aortic root dilatation, and intravenous immunoglobulin treatment response in different cohorts. A SMAD3 ...
Coronary artery aneurysms are the dilation of the coronary arteries that supply the heart tissue with blood and nutrients. The dilation exceeds 1.5 times the normal artery size. Complications can occur if these aneurysms rupture. Here is the latest research on coronary artery aneurysms. ...
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] ,25 kg/m2), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases ...
We thank Dr. Alfonso and colleagues for their kind letter in response to our paper (1). We agree that revascularization for patients with spontaneous coronary artery dissection (SCAD) is challenging and often terminates with suboptimal results, and thus we have adhered to a conservative approach unless patients have ongoing or recurrent ischemia. Indeed, repeat angiography in a subset of patients treated conservatively invariably demonstrated spontaneous healing of dissections (1). Our cohort included all nonatherosclerotic SCAD cases identified and evaluated in our center (no patient was excluded). We recently reported good long-term outcomes in our expanded cohort of 86 SCAD patients at the 2013 American College of Cardiology meeting, despite our low revascularization rate (2). Our results, together with your reported cohort of 45 SCAD patients in Spain (3), confirm that the natural history of SCAD is such that the vast majority heals spontaneously. Thus, clinicians should avoid intervention ...
Did you know that 90 percent of spontaneous coronary artery dissections - which involve a tear in an artery in the heart - occur in women? Or that the standard therapy for heart failure is less effective in women than in men? These cardiovascular differences among the sexes are fairly well known in the clinical and research communities. Why they exist, however, is not. And thats what a group of experts at the Frankel Cardiovascular Center at Michigan Medicine is trying to find out.. In honor of Heart Month, heres a closer look at M-BRISC, the Michigan Biological Research Initiative on Sex Differences in Cardiovascular Disease.. A unique approach. M-BRISC was created thanks to a generous, anonymous gift to the Frankel Cardiovascular Center. The initiative brings together collaborators from across the university to increase investigation designed to understand the mechanisms of cardiovascular disease that differentially affect women and factors underlying the health of women.. "What sets us ...
This case report is on a 69-year old male patient treated with cephalosporins because of suspected myocarditis due to borreliosis. Using transthoracic echocardiography a big aneurysm of the proximal part of the left coronary artery was detected. Coronary angiography revealed an aneurysm 1.2 cm in di …
Coronary artery bypass grafting (CABG) was performed under mild hypothermia, extracorporeal circulation, and aortic clamping. The internal thoracic artery was anastomosed in the distal portion of the LAD coronary artery, a dissection-free segment, and the great saphenous vein was anastomosed in a large-caliber 2nd diagonal branch, whose origin was in the false lumen. Cardiopulmonary bypass and cross-clamping times were 35 and 26 minutes, respectively.. Although conservative management has generally been associated with favorable outcomes, it is also associated with small hazard of dissection progression and the consequent need for intervention[9]. Thus, the decision for revascularization, with PCI or CABG, should rely on clinical status, hemodynamic instability, and angiographic characteristics.. Comparing conservative versus aggressive management, Shamloo et al.[10] described that 21.2% of conservatively managed patients eventually required surgical or catheter-based interventions, but only ...
Kawasaki disease is an acute vasculitis affecting predominantly children. The disease leads to coronary artery ectasia and damage which further result in ischaemic heart disease, being the most common cause of myocardial infarction in childhood. The aetiology and guidelines for the definitive...
Aneurysms of the left main coronary artery are rare with an incidence of 0.1% in large angiographic series. The majority are atherosclerotic in origin. Other causes include connective tissue disorders, trauma, vasculitis, congenital, mycotic and idiopathic. The primary complication is myocardial ischemia or infarction, with rupture being rare. Treatment options include anticoagulation, custom made covered stents, reconstruction, resection, and exclusion with bypass. A 66 year-old man was referred for evaluation of a 2 × 2 centimeter saccular aneurysm originating from the distal left main coronary artery. There was associated calcification and mild stenosis of the LM. The workup was prompted by a non-ST elevation myocardial infarction suffered following a laparotomy for a ruptured appendix. The past medical history was pertinent for hypertension, hyperlipidemia, and a left carotid endarterectomy. Cardiopulmonary bypass with hyperkalemic cardioplegic arrest was utilized. The aneurysm was exposed in the
A 55 year old man presented with a 2 year history of angina of effort complicated by two myocardial infarctions. Coronary angiography confirmed fusiform aneurysm of the right coronary artery and disease of the left anterior descending coronary artery
It is clinical condition which is characterized by abnormal dilation of a part of the coronary artery. It can be occur due to coronary angiography. Some of..
Biscione, C., Mariano, E., Sergi, D., Tarsia, G., Viceconte, N., Bernardo, V., et al. (2012). Large coronary aneurysm following laser angioplasty of the left anterior descending coronary artery. JOURNAL OF CARDIOVASCULAR MEDICINE, 13(5), 334-335 ...
Today, SUSE is pleased to announce SUSE CaaS Platform 4 as part of a larger SUSE Application Delivery Solutions update, that also includes SUSE Cloud Application Platform 1.5.. SUSE CaaS Platform 4 raises the bar for robust Kubernetes platform operations with enhancements that expand platform scalability options, strengthen application security, and make it easier to keep pace with technology advancements. Integrating the latest releases of Kubernetes and SUSE Linux Enterprise, SUSE CaaS Platform 4 continues to provide industry leading application delivery capabilities as an enterprise-ready solution.. SUSE CaaS Platform 4 is also the first enterprise-grade Kubernetes Platform to integrate Cilium, an open source CNI Plugin for Kubernetes that leverages a powerful Linux Kernel technology called BPF, as default, resulting in advanced networking and security capabilities.. With SUSE CaaS Platform 4 you can:. Strengthen application security at scale with high performance packet filtering and network ...
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Chronic active Epstein-Barr virus infection (CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for the Epstein-Barr virus (EBV). Prolonged fever, hepatosplenomegaly, lymphadenopathy, and liver dysfunction were seen in CAEBV, but
OBJECTIVES: To determine whether coronary artery lesions (ectasia and aneurysm) are commonly observed on the initial echocardiogram of patients with acute Kawasaki syndrome, whether coronary artery ectasia and/or aneurysms occur more frequently in patients with incomplete Kawasaki syndrome than in those patients with complete findings, and whether earlier diagnosis and treatment of Kawasaki syndrome are associated with less frequent occurrence of coronary artery ectasia and/or aneurysm.. DESIGN: A retrospective medical record review.. SETTING: A tertiary care pediatric hospital.. PARTICIPANTS: One hundred patients treated for Kawasaki syndrome between July 1, 1998, and June 30, 2003, who were identified by a medical record search.. MAIN OUTCOME MEASURE: Prevalence of coronary artery lesions (ectasia and aneurysm) on the initial and subsequent echocardiograms.. RESULTS: Forty-four percent of patients had a coronary artery lesion (31% with ectasia, 13% with aneurysm) on the initial echocardiogram. ...
A clinically significant cardiac injury occurs in 5% to 15% of patients with severe blunt chest trauma [1, 2, 3, 4]. Coronary artery dissection has a very low incidence. Coronary artery dissection due to blunt chest trauma is even less common and a life-threatening complication [5]. A traumatic dissection is most commonly seen in the LAD (76%), followed by the RCA (12%) and circumflex artery (6%) [6]. The mechanism is poorly understood, but the vulnerable anatomic position of the heart is probably the explanation why the LAD is most affected. The RCA is likely to be most vulnerable at its origin due to acceleration/deceleration injuries [7].. Christensen et al. reviewed 76 published cases of post-traumatic myocardial infarctions [8]. In almost 90% of the cases, the myocardial infarctions were due to motor vehicle collisions or high-velocity trauma. In about 70% of these cases, the infarction was caused by occlusion or dissection of a coronary artery. The presentation or recognition of a ...
8 mm). Saccular and fusiform aneurysms usually develop between 18 and 25 days after the onset of illness. Even when treated with high-dose IVIG regimens within the first 10 days of illness, 5% of children with Kawasaki disease develop at the least transient coronary artery dilation and 1% develop giant aneurysms. Death can occur due either to myocardial infarction secondary to blood clot formation in a coronary artery aneurysm or to rupture of a large coronary artery aneurysm. Death is most common two to 12 weeks after the onset of illness. Many risk factors predicting coronary artery aneurysms have been identified, including persistent fever after IVIG therapy, low hemoglobin concentrations, low albumin concentrations, high white-blood-cell count, high band count, high CRP concentrations, male sex, and age less than one year. Coronary artery lesions resulting from Kawasaki disease change dynamically with time. Resolution one to two years after the onset of the disease has been observed in half ...
BACKGROUND: Myocardial fibrosis and perfusion abnormalities can occur in patients with Kawasaki disease (KD). We explored using the new three-dimensional speckle tracking echocardiography (3DSTE) the left ventricular (LV) mechanics in adolescents and young adults with a history of KD.. METHODS: Twenty-five KD patients (18 males) aged 17.0 ± 5.2 years, 14 with (group I) and 11 without (group II) coronary aneurysms, were studied. The 3D volume datasets were acquired for quantification of LV global 3D strain, global and regional area strain, systolic dyssynchrony index (SDI), twist, twist gradient (twist/LV length), and ejection fraction.. RESULTS: The results were compared with those of 14 age-matched controls. Of the 14 group I patients, 6 had left, 2 had right, and 6 had both left and right coronary aneurysms. Compared with controls, group I patients had significantly lower LV systolic global 3D strain (43.7 ± 7.3% vs. 50.4 ± 6.6%, P = 0.02), twist (8.7 ± 1.3° vs. 11.4 ± 2.0°, P , 0.001), ...
This report describes a 48-year-old woman with Parkinson"s disease who developed coronary artery dissection. We believe that dissection in this patient was probably caused by treatment with the anti-Parkinsonian drug pergolide.. ...
Kawasaki disease is a leading cause of acquired heart disease among children in the United States and other developed countries. Most children who contract this illness are less than two years old, and 80 percent of affected children are younger than five years of age. A generalized vasculitis of unknown etiology, Kawasaki disease can cause coronary artery abnormalities, including coronary aneurysms. From 20 to 25 percent of untreated children develop coronary artery abnormalities, which may resolve or persist. These abnormalities are of particular concern because they can lead to thrombosis, evolve into segmental stenosis or, rarely, rupture. The principal cause of death from Kawasaki disease is myocardial infarction. The cause of the disease remains unknown, but epidemiologic investigations and the clinical presentation suggest a microbial agent. Diagnostic criteria, including fever and other principal features, have been established. In the acute phase of the disease, treatment with acetylsalicylic
Abstract Background: Kawasaki disease is one of the leading causes of acquired heart disease in children. It is an acute self-limited vasculitis that predominantly affects infants and children younger than 5 years of age. These patients present with nonspecific symptoms, such as fever and lymphadenopathy, making the diagnosis challenging. This disease can have serious and potentially fatal outcomes, and prompt recognition of this disease is vital to the patients outcome. We present a complete review of the disease, including the epidemiology, pathophysiology, diagnosis and management of acute Kawasaki disease, the natural history of this disease, and follow up of these patients as they transition into the adult cardiology practice. Methods: Our systematic review information were collected from articles retrieved from PubMed library. Keywords that were used included; Kawasaki disease, coronary artery disease, coronary artery aneurysm, pediatric coronary artery disease, epidemiology of Kawasaki disease
BACKGROUND:. Kawasaki Disease (KD) is an inflammatory vasculitis of unknown etiology that affects infants and children and can cause coronary artery aneurysms. Standard therapy consists of 2 gm/kg of intravenous immune globulin plus high-dose aspirin in the acute phase, and low-dose aspirin in the convalescent phase. Some children do not respond to this therapy, and some children go on to develop coronary artery aneurysms in spite of aggressive treatment. This led to the design of this randomized controlled trial to compare a single dose of intravenous steroids vs. placebo on the background of standard therapy. Recruitment began in December, 2002 and ended in December, 2004 with nearly 200 patients randomized.. DESIGN NARRATIVE:. This is a randomized controlled trial to compare a single dose of intravenous steroids vs. placebo on the background of standard therapy ...
Without treatment, about 1 in 5 children who have Kawasaki disease develop inflammation of the blood vessels to the heart (coronary arteries). This can cause a swelling of a section of an artery, which is called an aneurysm.. A coronary artery aneurysm usually causes no symptoms. Over time it often goes away and the artery returns to normal. However, the wall of an aneurysm is weakened and abnormal. Serious problems may develop in some children with an aneurysm. The most serious is that a clot (thrombosis) may develop in the aneurysm. The muscle of the heart is supplied with oxygen, carried in the blood of these arteries. If a clot develops, the muscle does not get enough oxygen. The heart muscle can then be damaged, causing a heart attack. Currently less than 1 in 100 children with Kawasaki disease die of heart problems.. An aneurysm can be detected by a heart scan (an echocardiogram). If an aneurysm does occur, it starts to develop a week or more after the fever and other acute symptoms begin. ...
Kawasaki disease during pregnancy - What is the definition or description of: Kawasaki disease? Kawasaki disease. Kawasaki disease is a rare disease of the blood vessels. Symptoms included fever > 5 days, red eyes, swollen red hands and feet, swollen red cracked lips and tongue, swollen neck lymph nodes and body rash. Kawasaki disease can also seriously affect the coronary heart vessels and gallbladder. It most commonly affects children under 8 years old. Cause of Kawasaki disease is unknown.
To explore effective and convenient rescue therapy options for coronary artery aneurysms (CAA) with thrombosis in Kawasaki disease (KD). A total of
TOKYO/NEW YORK - One of the top priorities in the fight against the coronavirus is to understand how, exactly, the pathogen attacks and kills.. The virus enters through the respiratory system. But it has also been found to cause complications in other parts of the body, such as the heart and kidneys, after it makes its way through the blood stream.. Earlier this month, New York State Gov. Andrew Cuomo raised alarm about another possible risk from the coronavirus - an inflammatory syndrome that entails similar symptoms to Kawasaki disease.. Is the new syndrome actually Kawasaki disease? Is there a cure? Here are six things to know.. What is Kawasaki disease?. Kawasaki disease is an acute inflammatory illness that affects blood vessels throughout the body. Children under age 5 are considered the most at risk, and it is more common in Asia and among individuals of Asian ancestry. The cause is unknown.. In Japan, 10,000 to 15,000 cases are reported annually.. Cardiac aneurysms are the most dangerous ...
Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine The article describes the modern views on the epidemiology, etiopathogenesis, clinical picture, diagnosis and treatment of Kawasaki disease. Kawasaki disease is a systemic disease with an acute course, which occurs mainly in children up to 5 years. The clinical pattern of disease resembles an infectious process, but on the basis of morphological changes it is referred to vasculitides, mainly affecting the blood vessels of medium caliber, and most often the coronary vessels. Kawasaki disease is a clinical diagnosis. The infusion of intravenous human immunoglobulin is using in treatment of the pathology. Key words: Kawasaki Disease, children, adolescents, epidemiology, pathogenesis, clinic, diagnostics, treatment. References 1. Berezhnyi VV, Herman OB. (2015). Khvoroba Takaiasu. Sovremennaya pediatriya. 8(72): 34-40. 2. Chernyshova LI, Volokha AP, Kostiuchenko LV et al. (2013). Dytiacha imunolohiia. Pidruchnyk. Za red prof LI ...
The risk of coronary artery lesions (CALs) in Kawasaki disease (KD) is related to CYP2E1 gene polymorphisms, a study from Taiwan confirmed.
Kawasaki disease, the leading cause of acquired heart disease in children in the United States, is characterized by inflammation of blood vessels throughout the body, especially the coronary arteries around the heart. The disease is most common in children under 5 years of age, occurs more often in boys than in girls, and is more prevalent during the winter and spring months.. Each year, there are roughly 2000 cases of Kawasaki disease in the United States. Although the exact cause of the disease remains unknown, experts suspect that it is caused, in part, by a pathogen such as a virus or bacteria, which may explain why cases often appear in clusters. At this time there are no means of prevention, nor is there evidence that the disease is contagious.. ...
The mission of CAAS Rounds is to bring together scientists from different disciplines and perspectives (e.g., psychologists, physicians, health care professionals) in order to stimulate expansive thinking, foster social interaction, and promote new collaborations at Brown. CAAS Rounds is a highly-regarded and well-attended series that welcomes the participation of staff, students, trainees, and faculty at Brown and its affiliated hospitals.. ...
For more than 30 years, pediatrician Jane Burns, M.D., has dedicated her research to solving the mystery of Kawasaki Disease (KD), a childhood illness characterized by fever, rash, red eyes, red lips, and red hands and feet that can lead to serious heart disease.
Kawasaki disease is a rare childhood illness that affects the blood vessels. The symptoms can be severe for several days and can look scary to parents. ..
Kawasaki disease is a rare disease, cause unknown, self-limited and fever blisters, which primarily affects children, and producing important alterations of blood vessels.
Researchers at University of California San Diego School of Medicine, with colleagues at Rady Childrens Institute for Genomic Medicine and in London and Singapore, have conducted novel whole genome sequencing of a family in which two of four children were affected by Kawasaki disease. They have identified plausible gene variants that predispose some children to developing the disease.
... is most common among children of Japanese and Korean descent, but can affect all ethnic groups. The first symptom is a high fever that lasts for at least 5 days.
... is most common among children of Japanese and Korean descent, but can affect all ethnic groups. The first symptom is a high fever that lasts for at least 5 days.
An international team of scientists report that the likely causative agent of Kawasaki disease (KD) in Japan is a windborne agent originating from a source in northeast China.
Doctors say that the childhood illness that Oscar-winning Hollywood star John Travoltas son Jett had been suffering from, scientifically called Kawasaki disease, could not be blamed
Download Kawasaki Vulcan 800 VN 800 1996-2002 All Service Manual Repa, Kawasaki Vulcan 800 VN 800 1999-2004 All Service Manual, 1999-2004 Kawasaki Vulcan 800 VN 800 Service Repair Manual, 2004 Kawasaki VULCAN 2000 VN 2000 Service Repair Factory Manual INSTANT DOWNLOAD , ...
This disease was first reported in English medical literature in 1967 by a Japanese paediatrician named Tomisaku Kawasaki (the disease has bee...
Amaç: Kawasaki Hastalığı daha çok beş yaş altında görülen, nedeni tam olarak bilinmeyen koroner arter tutulumu nedeniyle önemli morbidite ve mortalite sebebi olan, akut sistemik bir vaskülittir. Klinik olarak beş günden uzun süren ateşle birlikte, bilateral eksudatif olmayan konjonktivit, dudaklarda kızarıklık ve çatlaklar, oral mukozada eritem, vücutta polimorfik döküntü, ekstremite distalinde eritem ve ödem, tek taraflı servikal lenfadenopati ile karakterizedir. Koroner arter tutulumu ise en önemli prognostik faktördür. Bu çalışmada Başkent Üniversitesi Tıp Fakültesi Ankara Hastanesine başvuran ve Kawasaki Hastalığı tanısı alıp tedavi edilen olguların demografik özellikleri, klinik verileri, laboratuvar bulguları, ekokardiyografi bulguları ve kardiyak kateterizasyon bulgularının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Başkent Üniversitesi Tıp Fakültesi Ankara Hastanesine 2003-2017 yılları arasında başvuran ve Kawasaki ...
Learn about the causes, symptoms, diagnosis & treatment of Miscellaneous Disorders in Infants and Young Children from the Home Version of the Merck Manuals.
Learn more about this condition that primarily affects young children and causes inflammation in the walls of the arteries throughout the body.
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Since 1979, Lurie Childrens Division of Infectious Diseases has cared for more than 1,600 children with Kawasaki disease. The Center, established in 1998, is internationally known as one of the most active centers of research of the disease.
The Elizabeth Anne and Karen Barlow Corrigan Womens Heart Health Program at Massachusetts General Hospital provides a unique clinical service - cardiac care designed specifically for women. Because there are differences in the way men and women present heart disease, it is important to have specialists fluent in diagnosing and treating female patients.. This dedicated clinic focuses on all aspects of cardiology, from preventive approaches to complex conditions such as spontaneous coronary artery dissection. Specialists meet with women of all adult ages to discuss their current condition or their risk for heart disease.. ...
Kawasaki disease (KD) is a form of vasculitis affecting both the myocardium and coronary arteries. Coronary aneurysms develop in 15% to 25% of untreated patients (1,2). Myocardial inflammation is nearly universal during the acute phase (100% of cases in both post-mortem analysis and myocardial biopsy). However, there are no data about cardiac involvement during the convalescence of KD (1,2). Our aim was to evaluate the heart during the convalescence of KD by cardiac magnetic resonance (CMR). Thirteen KD patients, 6 to 8 years of age who fulfilled the currently used criteria for KD diagnosis, were evaluated by CMR 20 to 40 days after the onset of the disease. Patients were treated with high-dose immunoglobulin within the first 10 days of fever and responded well. Troponin I levels were normal in all except 1 patient, who had ST-segment elevation in II, III, and aVF. Patients were re-evaluated by CMR 3 months later.. Coronary arteries were examined using a 3-dimensional segmented k-space ...
Health care providers in Colorado have had considerable experience with KS. There have been 3 outbreaks in Colorado investigated by the Centers for Disease Control and Prevention in the last 20 years, and physicians throughout the state have aided in these investigations.3,8,9 The Childrens Hospital (Denver) is a large tertiary care pediatric hospital, and our infectious-disease group routinely takes calls from providers throughout the state for questions and referrals related to KS. Questions regarding KS are one of our most common telephone inquiries, indicating that KS is often considered in the differential diagnosis of febrile children. Our infectious-disease group requests that patients with possible KS be referred to our center for diagnosis and treatment. Therefore, we were concerned by the fact that 23.6% of children with KS were diagnosed after day 10 of illness.. Late diagnosis is problematic because patients in the DDG were more likely to develop coronary artery aneurysms than those ...
The cardiac complications are the most important aspect of the disease. It is the main cause of heart disease acquired in childhood in the United States of America and in Japan.[12] In the United States and other developed nations, it appears to have replaced acute rheumatic fever as the most common cause of acquired heart disease in children.[17] Coronary artery aneurysms occur as a sequela of the vasculitis in 20-25% of untreated children.[51] It is first detected at a mean of 10 days of illness and that the peak frequency of coronary dilatation or aneurysms occurs within 4 weeks of onset.[47] Aneurysms are classified into small (internal diameter of vessel wall ,5mm), medium (diameter ranging from 5-8mm), and giant (diameter , 8mm).[12] Saccular and fusiform aneurysms usually develop between 18 and 25 days after the onset of illness.[17] Even when treated with high-dose IVIG regimens within the first ten days of illness, 5% of children with Kawasaki disease develop at the least transient ...
1) Kawasaki disease was first reported as an acute febrile mucocutaneous lymph-node syndrome by Tomisaku Kawasaki in 1967.. (2) It is referred to as a self-limited acute vasculitis, which predominantly strikes children three months to five years of age. However, some cases have been reported in adults.. (3) Kawasaki disease is most prevalent in Japan, while Korea holds the second place as to the number of patients. Its incidence in Japanese and Korean children living in the USA and following a Western lifestyle is higher than in Caucasian children. In Japan 1% of children develop the disease by age five. (4) With control of rheumatic heart disease, Kawasaki disease is recognized as the most common acquired childhood heart disease in developed nations. Severely affected patients show coronary artery lesions such as aneurysms and ectasias, which develop in approximately one quarter of untreated children.. (5) Clinical manifestations of Kawasaki disease include prolonged fever (1-2 weeks, mean ...
Kawasaki Disease What is Kawasaki disease? Kawasaki disease is the most common form of vasculitis that primarily affects children. The disease produces irritation and inflammation of many tissues of the body, including the hands, feet, whites of the eyes, mouth, lips, and throat. High fever and swelling of the lymph nodes in the neck also are characteristic of this illness. While most children completely recover, the main threat from Kawasaki disease comes from its effect on the heart and blood vessels....
After more than four decades of research, strong evidence now shows that Kawasaki disease has a distinct seasonal occurrence shared by regions across the Northern hemisphere.. The first global analysis of the seasonality of Kawasaki disease, published September 18 by PLOS ONE, was carried out using data obtained between 1970 and 2012. It included 296,203 cases from 39 locations in 25 countries around the globe, with 27 of those locations in the extra-tropical Northern hemisphere, eight in the tropics, and four in the extra-tropical Southern hemisphere.. Kawasaki disease (KD) is a severe childhood disease that many parents, even some doctors, mistake for an inconsequential viral infection. In fact, if not diagnosed or treated in time, it can lead to irreversible heart damage. Decades of research have been unable to pinpoint the cause of the disease, although genetic studies show a heritable tendency to acquiring the disease.. Findings of an international team of scientists - organized by Jane C. ...
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TY - JOUR. T1 - Kawasaki disease. AU - Marchesi, Alessandra. AU - Tarissi de Jacobis, Isabella. AU - Rigante, Donato. AU - Rimini, Alessandro. AU - Malorni, Walter. AU - Corsello, Giovanni. AU - Bossi, Grazia. AU - Buonuomo, Sabrina. AU - Cardinale, Fabio. AU - Cortis, Elisabetta. AU - De Benedetti, Fabrizio. AU - De Zorzi, Andrea. AU - Duse, Marzia. AU - Del Principe, Domenico. AU - Dellepiane, Rosa Maria. AU - DIsanto, Livio. AU - El Hachem, Maya. AU - Esposito, Susanna. AU - Falcini, Fernanda. AU - Giordano, Ugo. AU - Maggio, Maria Cristina. AU - Mannarino, Savina. AU - Marseglia, Gianluigi. AU - Martino, Silvana. AU - Marucci, Giulia. AU - Massaro, Rossella. AU - Pescosolido, Christian. AU - Pietraforte, Donatella. AU - Pietrogrande, Maria Cristina. AU - Salice, Patrizia. AU - Secinaro, Aurelio. AU - Straface, Elisabetta. AU - Villani, Alberto. PY - 2018/8/30. Y1 - 2018/8/30. N2 - The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt ...
Welcome to the website of Dr. Paul Christakis. Our goal at Christakis Pediatrics is to provide compassionate and up-to-date medical care for children of all ages in a personal, small office setting.
Kawasaki disease causes inflamed blood vessels. It can weaken the walls of blood vessels, including the arteries of the heart. Kawasaki mostly affects infants and young children. It is uncommon in the U.S.
platelets (PLATE-lets) are tiny disk-shaped particles within the blood that play an important role in clotting (the bodys way of thickening blood to stop bleeding). * echocardiogram (eh-ko-KAR-dee-uh-gram) is a diagnostic test that uses sound waves to produce images of the hearts chambers and valves and blood flow through the heart. * coronary arteries (KOR-uh-nair-e AR-tuh-reez) are the blood vessels that directly supply blood to the heart. * blood clots are thickenings of the blood into a jelly-like substance that helps stop bleeding. Clotting of the blood within a blood vessel can lead to blockage of blood flow. * gamma globulin (GAH-muh GLAH-byoo-lin) is a type of protein in the blood that contains the antibodies produced by the cells of the bodys immune system that help defend the body against infection-causing germs, such as bacteria and viruses. * Reye syndrome (RYE SIN-drome) is a rare condition that involves inflammation of the liver and brain, and sometimes appears after illnesses ...
Adding infliximab to standard intravenous immunoglobulin to reduce inflammation in acute Kawasaki disease is safe in children, even those younger than 1 year, according to a phase 3 randomized trial presented at IDWeek 2012.
A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have my
Abstract In spite of many reports of recurrent Kawasaki disease, little information about the risk factors associated with recurrence is available. We conducted a case-control study on 150 cases of...
While Kawasaki disease is rare, its important to be aware of because its easily misdiagnosed as other viral illnesses. Read 5 things to remember about it:
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Sigma-Aldrich offers abstracts and full-text articles by [Côme Tissandier, Matthieu Lang, Jean René Lusson, Benoit Bœuf, Etienne Merlin, Claire Dauphin].
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If you have a question about this talk, please contact Laurent Simon.. Abstract: There is a strong demand for a secure cryptographic platform in cloud and mobile computing to support variety of sensitive applications. When used in large scale distributed environments, one of the options is to provide cryptography operations as a service (CaaS) instead of computed on end-user device. It is crucial for CaaS to be trusted by its users as the cryptographic material is accessed and can be compromised. One option is to execute sensitive operations inside a trusted hardware module (HSM) so even platform operator is not able to access used cryptographic material. Current HSMs provides reasonable computational performance for closed centralised systems (e.g., top HSMs can perform up to 9,000 RSA 1024b signatures per second). But implementing CaaS for different operations with distinct keys submitted by many users in parallel with currently available HSMs comes with a number of challenges, though. The ...
Learn about the causes, symptoms, diagnosis & treatment of Miscellaneous Disorders in Infants and Children from the Professional Version of the Merck Manuals.
Sigma-Aldrich offers abstracts and full-text articles by [Vered Padler-Karavani, Adriana H Tremoulet, Hai Yu, Xi Chen, Jane C Burns, Ajit Varki].
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Flanagan CM, Kaesberg JL, Mitchell ES, Ferguson MA, Haigney MC (2008). «Coronary artery aneurysm and thrombosis following ... 2004). «Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease». N. Engl. J. Med. ... 2006). «The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk ... 2006). «Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic ...
Atherosclerosis can lead to coronary artery disease, carotid artery disease, peripheral artery disease, and aneurysms. Standing ...
A rare complication of this condition are coronary artery aneurysms. Although the cause of Takayasu arteritis is unknown, the ... In the late stage, weakness of the arterial walls may give rise to localized aneurysms. As with all aneurysms, the possibility ... "Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treatment". Frontiers in ... This inflammation leads to arterial stenosis, thrombosis, and aneurysms. There is irregular fibrosis of the blood vessels due ...
... infarction secondary to blood clot formation in a coronary artery aneurysm or to rupture of a large coronary artery aneurysm. ... axillary artery aneurysm, brachiocephalic artery aneurysm, aneurysm of iliac and femoral arteries, and renal artery aneurysm. ... fusiform rather than saccular aneurysm morphology, and an aneurysm location in a distal coronary segment. The highest rate of ... In some children, coronary artery aneurysms may form in the heart after 1-2 years. The cause is unknown. It may be due to an ...
15 to 25 percent of these cases developed coronary artery aneurysms. The overproduction of T cells may be correlated with the ... "ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms". Nat ... "ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation ...
The condition can be mimicked by a ruptured cyst of the pericardium, ruptured aortic aneurysm and acute coronary syndrome. ... 2007). "Thoracic aortic aneurysm: direct sign of rupture" (pdf). Cardiovasc J Afr. 18 (3): 180-1. PMID 17612751. Nishigami K, ... It is possible for AAS to lead to acute coronary syndrome. The term was introduced in 2001. Causes can include aortic ... dissection, intramural hematoma, penetrating atherosclerotic ulcer or a thoracic aneurysm that has become unstable. The ...
... a systemic vasculitis in childhood that may result in aneurysms of the coronary arteries. In the developed world, Kawasaki ...
Persistent hypertension is a major risk factor for hypertensive heart disease, coronary artery disease, stroke, aortic aneurysm ... and arterial aneurysm) in hypertensive persons. The endothelium of blood vessels produces an extensive range of substances that ...
Coronary revascularization Valve surgery Congenital heart repair Aortic aneurysm repair Non-invasive Cardiology Interventional ...
Aneurysm and dissection of heart (414.10) Aneurysm of heart (wall) (414.11) Aneurysm of coronary vessels (414.12) Dissection of ... Abdominal Aortic Aneurysm, ruptured (441.4) Abdominal aortic Aneurysm, w/o rupture (441.9) Abdominal Aortic Aneurysm, ... Aneurysm of pulmonary artery (417.8) Other specified diseases of pulmonary circulation (417.9) Unspecified disease of pulmonary ... Intermediate coronary syndrome (412) Old myocardial infarction (413) Angina pectoris (413.0) Angina decubitus (413.1) ...
... for abdominal aortic aneurysm repair, coronary artery bypass, aortic valve repair and mitral valve repair. Risk-adjusted ... mortality was found to be statistically significantly lower in the Healthgrades' "Best Hospitals" for coronary artery bypass ...
... syndactyly jejunal atresia Coronaro-cardiac fistula Coronary arteries congenital malformation Coronary artery aneurysm Coronary ... lipoid Congenital afibrinogenemia Congenital alopecia X linked Congenital amputation Congenital aneurysms of the great vessels ... familial Cerebral amyloid angiopathy Cerebral aneurysm Cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Michler has performed nearly 5,000 open heart procedures ranging from complex valve repair, coronary artery bypass, and ... aneurysm surgery to heart transplantation and mechanical hearts in his 25-year career. He is a noted authority in all types of ... the STICH Hypothesis 2 Investigators.Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction. N Engl J Med ... Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. J ...
Aneurysm of heart (I25.4) Coronary artery aneurysm (I25.5) Ischaemic cardiomyopathy (I25.6) Silent myocardial ischaemia (I25.8 ... Aortic aneurysm of unspecified site, ruptured (I71.9) Aortic aneurysm of unspecified site, without mention of rupture (I72) ... Aortic aneurysm and dissection (I71.0) Dissection of aorta (any part) (I71.1) Thoracic aortic aneurysm, ruptured (I71.2) ... Thoracic aortic aneurysm, without mention of rupture (I71.3) Abdominal aortic aneurysm, ruptured (I71.4) Abdominal aortic ...
1958 - The first open-heart surgery in mid-Missouri performed at University Hospital 1962 - A giant coronary artery aneurysm ...
... aortic aneurysm repair, coronary bypass surgery, hypertrophic cardiomyopathy/myectomy and minimally invasive cardiac surgery. ...
T-cell and NK-cell lymphomas Haemophagocytic syndrome Coronary artery aneurysms Liver failure Nasopharyngeal carcinoma Gastric ...
... coronary artery disease) Aneurysm leakage Cardiac tamponade Shock Past history of myocardial infarction History of kidney ... The right coronary artery is involved more commonly than the left coronary artery. If the myocardial infarction is treated with ... About 29% of late deaths following surgery are due to rupture of either a dissecting aneurysm or another aneurysm. In addition ... These new aneurysms are more likely to rupture, due to their thinner walls. Serial imaging of the aorta is suggested, with MRI ...
He underwent coronary artery bypass surgery, and also suffered from a leaking aortic aneurysm, and a perforated Meckel's ...
... including coronary artery aneurysms, ventricular aneurysms, aneurysm of sinus of Valsalva, and aneurysms following cardiac ... Without treatment, these aneurysms will ultimately progress and rupture. Infection. A mycotic aneurysm is an aneurysm that ... Capillaries, specifically capillary aneurysms. Cerebral aneurysms, also known as intracranial or brain aneurysms, occur most ... The aorta, namely aortic aneurysms including thoracic aortic aneurysms and abdominal aortic aneurysms. The brain, including ...
Left ventricular aneurysm as seen on ultrasound It should also not be confused with a pseudoaneurysm, coronary artery aneurysm ... Coronary artery aneurysm "What is an Aneurysm?". www.heart.org. Retrieved 2017-03-14. Victor F. Froelicher; Jonathan Myers ( ... Ventricular aneurysms usually grow at a very slow pace, but can still pose problems. Usually this type of aneurysm grows in the ... Ventricular aneurysms are one of the many complications that may occur after a heart attack. The word aneurysm refers to a ...
... or aneurysms that can rupture and result in death. The damage can result in angina which is pain in the chest and is a common ... Coronary artery collateral circulation in patients of coronary ectasia with significant coronary artery disease.PLOS ONE,9(1), ... Coronary artery ectasia is a rare disease that occurs in only 0.3-4.9% of people in North America. Coronary artery ectasia is ... Coronary artery ectasia also increases the chance of developing large weak spots in the affected coronary arteries, ...
... is an abnormal dilatation of part of the coronary artery. Acquired causes include atherosclerosis, ... May 2007). "Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence". Circ. J. 71 (5 ... Seabra-Gomes R, Somerville J, Ross DN, Emanuel R, Parker DJ, Wong M (April 1974). "Congenital coronary artery aneurysms". Br ... Nichols L, Lagana S, Parwani A (May 2008). "Coronary artery aneurysm: a review and hypothesis regarding etiology". Arch. Pathol ...
... results in coronary artery aneurysms). Myocardial infarction from coronary thrombosis is the most common cause of death from ... Coronary artery disease (CAD)- Coronary artery disease is a general term for any reduction in coronary circulation. One such ... Aortic aneurysm - Aneurysm of the aorta, typically of the abdominal aorta (abdominal aortic aneurysm or AAA). They are ... Cerebral aneurysm - Aneurysms of the arteries in the brain most commonly affect the anterior cerebral artery. Rupture of the ...
Acute coronary syndrome Air embolism (arterial) Aortic aneurysm (ruptured) Abdominal aortic aneurysm Aortic dissection Bleeding ...
2009). «Integrative predictive model of coronary artery calcification in atherosclerosis». Circulation. 120 (24): 2448-54. PMC ... Jan SL, Chan SC, Fu YC, Lin SJ (2009). «Elastin gene study of infants with isolated congenital ductus arteriosus aneurysm.». ...
Coronary artery aneurysm is an abnormal dilatation of part of the coronary artery. Acquired causes include atherosclerosis, ... May 2007). "Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence". Circ. J. 71 (5 ... Seabra-Gomes R, Somerville J, Ross DN, Emanuel R, Parker DJ, Wong M (April 1974). "Congenital coronary artery aneurysms". Br ... Nichols L, Lagana S, Parwani A (May 2008). "Coronary artery aneurysm: a review and hypothesis regarding etiology". Arch. Pathol ...
Computed tomography and coronary angiography showed that the aneurysm and coronary-pulmonary artery fistula had completely ... Chest computed tomography and coronary angiography revealed a giant aneurysm and coronary-pulmonary artery fistula originating ... A Case of Coronary-Pulmonary Artery Fistula with a Giant Aneurysm. (Department of Cardiovascular Surgery, Iwate Prefectural ... from both the proximal left anterior descending and the right coronary artery. The fistula was ligated and the aneurysm was ...
Background: Children with giant coronary artery aneurysms (CAA) after Kawasaki disease (KD) are at substantial risk of ... Abstract O.71: Thrombosis and Thromboprophylaxis for Patients with Giant Coronary Artery Aneurysms after Kawasaki Disease: A ... Abstract O.71: Thrombosis and Thromboprophylaxis for Patients with Giant Coronary Artery Aneurysms after Kawasaki Disease: A ... Abstract O.71: Thrombosis and Thromboprophylaxis for Patients with Giant Coronary Artery Aneurysms after Kawasaki Disease: A ...
Citation: Deser SB, Demirag MK (2016) Asaccular Aneurysm of the Ascending Aorta Following Coronary Artery Bypass Graft Surgery ... Asaccular Aneurysm of the Ascending Aorta Following Coronary Artery Bypass Graft Surgery ... An aneurysm is defined as dilatation of the artery greater than 50% in diameter. Aneurysms are categorized as fusiform or ... Aneurysm repair wasrecommended for all saccular aneurysms of the ascending aorta regardless of size or symptoms. ...
Aneurysm, Dissecting. Coronary Vessel Anomalies. Vascular Diseases. Aneurysm. Cardiovascular Diseases. Heart Defects, ... Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD). This study is currently recruiting participants. See ... Patient information on spontaneous coronary artery dissection Publications: Tweet MS, Gulati R, Aase LA, Hayes SN. Spontaneous ... Familial spontaneous coronary artery dissection: evidence for genetic susceptibility. JAMA Intern Med. 2015 May;175(5):821-6. ...
6. Management of Aneurysm. Indication for surgery in left main aneurysm is angina, obstructive coronary stenosis. Coronary ... Coronary artery aneurysm is defined when coronary arterial segments dilates ,1.5 times of normal adjacent coronary segments or ... CT Coronary angiogram showing left main aneurysm with ostial LAD stenosis. (b) CT Coronary angiogram showing left main aneurysm ... Left main aneurysm seems to be the rarest with an incidence of 0.1%. The most common cause of coronary aneurysm mostly seems to ...
Coronary angiography confirmed fusiform aneurysm of the right coronary artery and disease of the left anterior descending ... Coronary Aneurysm / complications, radiography, surgery*. Coronary Angiography. Coronary Artery Bypass. Humans. Male. Middle ... Coronary angiography confirmed fusiform aneurysm of the right coronary artery and disease of the left anterior descending ... The patient underwent surgery with exclusion of the right coronary artery aneurysm and reversed saphenous vein graft, and graft ...
Background Coronary artery aneurysm can be defined as an abnormal dilatation of the coronaries. In recent years, the disease ... Luo Y, Tang J, Liu X, Qiu J, Ye Z, Lai Y, Yao Y, Li J, Wang X, Liu X (2016) Coronary artery aneurysm differs from coronary ... Coronary artery aneurysm can be defined as an abnormal dilatation of the coronaries. In recent years, the disease has been ... Coronary artery aneurysm (CAA) is defined as the diameter of the lumen of the coronary artery, generally exceeding 1.5 times ...
coronary artery aneurysm synonyms, coronary artery aneurysm pronunciation, coronary artery aneurysm translation, English ... dictionary definition of coronary artery aneurysm. coronary artery aneurysm. Translations. English: cor·o·nar·y ar·ter·y ... Coronary artery aneurysm (CAA) is defined as focal or diffuse dilatation of a coronary artery more than 1.. Giant coronary ... Key Words: Coronary artery aneurysm Multi-detector computed tomography Coronary angiography Coronary CT angiography.. ...
Coronary artery aneurysm due to primary cardiac lymphoma.. Gardiner DS1, Lindop GB. ...
... of patients undergoing coronary angiography; Coronary Artery Aneurism (CAA) also occurs in approximately 15-19% of patients ... It is usually congenital, but in rare occasions it occurs after chest trauma, cardiac surgery, or coronary interventions. The ... Coronary Arteriovenous Fistula (CAF) is a rare defect that occurs in 0.1-0.2% ... "Giant coronary artery aneurysm with coronary arteriovenous fistula draining into the coronary sinus," Journal of Anesthesia, ...
We present here KD patient with small coronary artery aneurysm who is resistant to the third IVIG and steroid pulse therapy but ... within the first 10 days of illness has been shown to reduce the incidence of coronary artery aneurysms significantly. The ... their effectiveness in reducing the prevalence of coronary artery aneurysms was unproven. ... showed a small aneurysm of the left main coronary artery (4.1 mm) and mild dilatation of the left anterior descending coronary ...
... (Department of Cardiovascular Surgery ... This study was designed to evaluate the optimal surgical treatment strategy for abdominal aortic aneurysm (AAA) coexisting with ... coronary artery disease (CAD). Twenty-six patients (21 men and 5 women with a mean age of 72.6 }3.7years old) who required ...
Ken Kishida (September 6th 2011). An Infected Drug-Eluting Stented Coronary Aneurysm Forming Intracardiac Fistula, Coronary ... Ken Kishida (September 6th 2011). An Infected Drug-Eluting Stented Coronary Aneurysm Forming Intracardiac Fistula, Coronary ... Coronary AngiographyAdvances in Noninvasive Imaging Approach for Evaluation of Coronary Artery DiseaseEdited by Baskot ... An Infected Drug-Eluting Stented Coronary Aneurysm Forming Intracardiac Fistula. By Ken Kishida ...
The incidence of coronary aneurysm was 3.1 % (19/614). Among the 19 coronary aneurysm patients (pts, Male 16, Age 61.68± 10.37 ... The biggest aneurysm was seen in the PES (diameter 9.7 mm). IVUS demonstrated focal lack of contact between DES and coronary ... Abstract 3434: Incidence and Characteristics of Coronary Aneurysm after Drug-eluting Stent Implantation. Seung-Woon Rha, Sunil ... Background: Drug-eluting stents (DES) may induce toxic effects on the coronary arterial wall such as aneurysm formation, ...
Coronary angiogram 6 months after PTCA showing saccular aneurysm at site of PTCA (arrows). A, Right anterior oblique view. B, ... Intravascular Ultrasound Diagnosis of a Coronary True Aneurysm After Palmaz-Schatz Stent Implantation. Teruo Noguchi, Akira ... Coronary angiogram and IVUS imaging of left circumflex artery. Angiogram revealed saccular aneurysm between 2 stents. IVUS ... IVUS can clearly differentiate a coronary aneurysm by directly visualizing the details of the wall morphology, offering ...
Selective coronary angiography at the age of 5 years and 7 months showed a giant aneurysm (diameter 8.6 mm) on the right ... and the other in the right coronary artery proximal to the formerly existing aneurysm (arrow). Mild localised stenosis was ... and calcification was apparent in the aneurysm at segment 2. Two new aneurysms were observed at age 16 years and 10 months, one ... detected at the proximal and distal ends of the aneurysm in segment 2. The aneurysm in segment 4 increased to a diameter of 4 ...
Non-atherosclerotic coronary artery aneurysms: two case reports Message subject: (Your Name) has forwarded a page to you from ...
... of 20 087 patients were observed at angiography to have coronary artery aneurysms.1 In this series, a coronary artery aneurysm ... of isolated non-atherosclerotic coronary artery aneurysms. We believe the management of isolated coronary artery aneurysms ... Case 2: coronary artery aneurysm of the left coronary artery in the (A) right anterior oblique cranial view and (B) the right ... Coronary angiography revealed a large coronary artery aneurysm arising from the mid-LAD (fig 1), subtending an area of apical ...
... or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the ... Coronary Aneurysm (Aneurysm, Coronary). Subscribe to New Research on Coronary Aneurysm Abnormal balloon- or sac-like dilatation ... 03/01/2008 - "Coronary aneurysm formation after primary coronary angioplasty.". 02/01/2004 - "Coronary aneurysms were not ... 10/01/2011 - "Multiple giant coronary aneurysms--exclusion by vein graft interposition.". 09/01/2009 - "Coronary aneurysms in a ...
... and bilateral coronary aneurysms were found. Microscopic studies revealed lymphoid vasculitis of coronary arteries, coronary ... An autopsy case of CAEBV with giant coronary aneurysms and aortic aneurysms is reported. The patient was a 5-year-old Japanese ... Coronary Aneurysm / etiology, pathology*, virology. Fatal Outcome. Female. Hepatitis, Chronic / pathology*. Herpesviridae ... To the best of the authors knowledge, pathology of aneurysms caused by lymphoid vasculitis in CAEBV has not been reported ...
At coronary angiography, left anterior descending coronary artery was occluded with distal perfusion by collateral flow, and ... Coronary Aneurysm / complications*, diagnosis*, therapy. Coronary Angiography. Coronary Artery Disease / complications*, ... and proximal coronary aneurysms involving proximal left circumflex (LCX) right coronary artery with diffuse coronary ... 20443654 - Three-vessel coronary artery disease with multi-vessel proximal aneurysms.. 7930224 - Delineation of extended ...
A 28 year old man had an acute myocardial infarction and was found to have coronary artery aneurysms. These may have been ... an entity that should be considered in adults presenting with proximal discrete coronary artery aneurysms. ...
Atherosclerotic coronary artery aneurysm progressing to coronary artery fistula: presentation as myocardial infarction with ...
... coronary aneurysms (four patients had sites of both large and small sized aneurysms); group 3 included a further five Kawasaki ... Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function.. Iemura M ... To investigate the long term consequences of regressed aneurysms after Kawasaki disease, using follow up coronary angiography; ... Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function ...
  • Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement. (clinicaltrials.gov)
  • Proximal and distal communications of RCA were ligated from within the aneurysmal sac and then coronary artery bypass graft surgery (CABG) was performed using right internal mammary artery to the distal RCA and left internal mammary artery to the LAD. (biomedcentral.com)