Corneal transplantation. Medical search

Partial or total replacement of the CORNEA from one human or animal to another.

Partial or total replacement of all layers of a central portion of the cornea.

Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.

Diseases of the cornea.

The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)

New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

Single layer of large flattened cells covering the surface of the cornea.

Centers for storing various parts of the eye for future use.

An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.

The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.

A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.

Presence of an intraocular lens after cataract extraction.

The transference of a part of or an entire liver from one human or animal to another.

A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.

Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.

Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

The transference of a kidney from one human or animal to another.

A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

The formation of LYMPHATIC VESSELS.

The transference of a heart from one human or animal to another.

Transplantation of an individual's own tissue from one site to another site.

Inflammation of the cornea.

The transference of either one or both of the lungs from one human or animal to another.

Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.

The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.

Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.

Transference of an organ between individuals of the same species or between individuals of different species.

The transference of a pancreas from one human or animal to another.

The number of CELLS of a specific kind, usually measured per unit volume or area of sample.

The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.

Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.

A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.

Transference of cells within an individual, between individuals of the same species, or between individuals of different species.

An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.

Non-cadaveric providers of organs for transplant to related or non-related recipients.

Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.

The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.

Causes of corneal graft failure in India. (1/579)

The success of corneal grafting in visual rehabilitation of the corneal blind in India depends on survival of the grafts. Understanding the causes of graft failure may help reduce the risk of failure. We studied these causes in a series of 638 graft failures at our institution. Multivariate logistic regression analysis was used to evaluate the association of particular causes of graft failure with indications for grafting, socioeconomic status, age, sex, host corneal vascularization, donor corneal quality, and experience of surgeon. The major causes of graft failure were allograft rejection (29.2%), increased intraocular pressure (16.9%), infection excluding endophthalmitis (15.4%), and surface problems (12.7%). The odds of infection causing graft failure were significantly higher in patients of lower socioeconomic status (odds ratio 2.45, 95% CI 1.45-4.15). Surface problems as a cause of graft failure was significantly associated with grafts done for corneal scarring or for regrafts (odds ratio 3.36, 95% CI 1.80-6.30). Increased intraocular pressure as a cause of graft failure had significant association with grafts done for aphakic or pseudophakic bullous keratopathy, congenital conditions or glaucoma, or regrafts (odds ratio 2.19, 95% CI 1.25-3.84). Corneal dystrophy was the indication for grafting in 12 of the 13 cases of graft failure due to recurrence of host disease. Surface problems, increased intraocular pressure, and infection are modifiable risk factors that are more likely to cause graft failure in certain categories of patients in India. Knowledge about these associations can be helpful in looking for and aggressively treating these modifiable risk factors in the at-risk categories of corneal graft patients. This can possibly reduce the chance of graft failure. (+info)

Streptococcal keratitis after myopic laser in situ keratomileusis. (2/579)

A 24-year-old healthy male underwent uncomplicated laser in situ keratomileusis (LASIK) in left eye. One day after the surgery, he complained of ocular pain and multiple corneal stromal infiltrates had developed in left eye. Immediately, the corneal interface and stromal bed were cleared, and maximal antibiotic treatments with fortified tobramycin (1.2%) and cefazolin (5%) were given topically. The causative organism was identified as 'Streptococcus viridans' both on smear and culture. Two days after antibiotic therapy was initiated, the ocular inflammation and corneal infiltrates had regressed and ocular pain was relieved. One month later, the patient's best corrected visual acuity had returned to 20/20 with -0.75 -1.00 x 10 degrees, however minimal stromal scarring still remained. This case demonstrates that microbial keratitis after LASIK, if treated promptly, does not lead to a permanent reduction in visual acuity. (+info)

Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases. (3/579)

AIMS: A prospective study was carried out in order to evaluate the efficacy and safety of peribulbar anaesthesia during keratoplasty and to describe surgical conditions. METHODS: Of 137 consecutive keratoplasties, 100 (73%) were performed under peribulbar anaesthesia. Patients received a mean volume of 16.5 (SD 4) ml (range 9-22 ml) of a mixture of etidocaine, bupivacaine, and hyaluronidase. Ocular compression duration was at least 20 minutes and intraocular pressure (IOP) was measured with a Tonopen after injection, compression, and before trephination. Degree of akinesia, pain scoring, complications, and surgical conditions were studied. RESULTS: Before trephination, IOP was 5.73 mm Hg below the preinjection value and was never above 21 mm Hg. Akinesia was complete in 80% of cases and 94% of patients found that surgery was painless. Two patients (2%) were very agitated during surgery. The last patient presented with an acute intraoperative suprachoroidal haemorrhage that did not result in a true expulsive haemorrhage despite an "open sky" situation. Surgical conditions were judged to be optimal by the patients in 92% of cases and by the surgeon in 98% of cases. CONCLUSION: These results demonstrate that peribulbar anaesthesia offers excellent anaesthesia and akinesia during keratoplasty and may be recommended for this type of surgery. (+info)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (4/579)

CD4+ T cells of the Th1 type play a central role in acute rejection of solid tissue grafts, including orthotopic corneal allografts. Th1 cells, which mediate delayed hypersensitivity, are the polar opposites of CD4+ Th2 cells, and the latter cells cross-regulate Th1 cells through the unique pattern of cytokines they secrete. As such, Th2 cells may have a useful role to play in preventing rejection of corneal allografts. To test this possibility, the immune systems of adult mice were biased toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA. When immunized subsequently with either OVA or allogeneic corneal tissue, these mice acquired Ag-specific primed T cells of the Th2 type. More important, allogeneic corneas grafted into neovascularized eyes of Th2-biased mice experienced significantly enhanced survival. To demonstrate that enhanced survival was promoted by donor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allografts suppressed orthotopic corneal allograft rejection when adoptively transferred into naive, syngeneic recipients. We conclude that acceptance of corneal allografts in neovascularized mouse eyes can be significantly enhanced by biasing the recipient immune system toward Th2 responses. (+info)

Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. (5/579)

BACKGROUND: Conditions that destroy the limbal area of the peripheral cornea, such as the Stevens-Johnson syndrome, ocular pemphigoid, and chemical and thermal injuries, can deplete stem cells of the corneal epithelium. The result is scarring and opacification of the normally clear cornea. Standard corneal transplantation cannot treat this form of functional blindness. METHODS: We performed and evaluated 70 transplantations of corneal epithelial stem cells from cadaveric eyes into 43 eyes of 39 patients with severe ocular-surface disorders and limbal dysfunction. Medical treatment had failed in all patients. The patients had a mean preoperative visual acuity of 0.004 (only being able to count the number of fingers presented by the examiner) in the affected eyes, which satisfies the criteria for legal blindness in most countries. In 28 eyes, we also performed standard corneal transplantation. Stem-cell transplantations were performed as many as four times on 1 eye if the initial results were not satisfactory; 19 eyes had multiple transplantations. Patients were followed for at least one year after transplantation. RESULTS: A mean of 1163 days after stem-cell transplantation, 22 of the 43 eyes (51 percent) had corneal epithelialization; of the 22 eyes, 7 eyes had corneal stromal edema and 15 eyes had clear corneas. Mean visual acuity improved from 0.004 to 0.02 (vision sufficient to distinguish the largest symbol on the visual-acuity chart from a distance of 1 m) (P<0.001). The 15 eyes in which the cornea remained clear had a final mean visual acuity of 0.11 (the ability to distinguish the largest symbol from a distance of 5 m). Complications of the first transplantation included persistent defects in the corneal epithelium in 26 eyes, ocular hypertension in 16 eyes, and rejection of the corneal graft in 13 of 28 eyes. The epithelial defects eventually healed in all but two of the eyes. CONCLUSIONS: Transplantation of corneal epithelial stem cells can restore useful vision in some patients with severe ocular-surface disorders. (+info)

Spherical and aspherical photorefractive keratectomy and laser in-situ keratomileusis for moderate to high myopia: two prospective, randomized clinical trials. Summit technology PRK-LASIK study group. (6/579)

OBJECTIVE: Determine the outcomes of single-zone photorefractive keratectomy (SZPRK), aspherical photorefractive keratectomy (ASPRK), and laser in-situ keratomileusis (LASIK) for the correction of myopia between -6 and -12 diopters. DESIGN: Two simultaneous prospective, randomized, multi-center clinical trials. PARTICIPANTS: 286 first-treated eyes of 286 patients enrolled in one of two studies. In Study I, 134 eyes were randomized to SZPRK (58 eyes) or ASPRK (76 eyes). In Study II, 152 eyes were randomized to ASPRK (76 eyes) or to LASIK (76 eyes). INTERVENTION: All eyes received spherical one-pass excimer laser ablation as part of PRK or LASIK performed with the Summit Technologies Apex laser under an investigational device exemption, with attempted corrections between -6 and -12 diopters. MAIN OUTCOME MEASURES: Data on uncorrected and best spectacle-corrected visual acuity, predictability and stability of refraction, and complications were analyzed. Follow-up was 12 months. RESULTS: At 1 month postoperatively, more eyes in the LASIK group achieved 20/20 and 20/25 or better uncorrected visual acuity than PRK-treated eyes; at the 20/25 or better level, the difference was significant for LASIK (29/76 eyes, 38%) over SZPRK (10/58 eyes, 17%) (P = .0064). At all subsequent postoperative intervals, no difference was seen between treatment groups. Similarly, best corrected visual acuities were better for LASIK than all PRK eyes at 1 month postoperatively, and LASIK was better than SZPRK at 3 months follow-up (e.g., for 20/20 or better at 1 month, LASIK 50/76 eyes (66%) versus SZPRK 24/57 eyes (42%), P = .0066). PRK eyes had a mean loss of BCVA through 6 months, while LASIK eyes had a slight gain of mean BCVA through month 6; at 12 months, both ASPRK groups but not SZPRK continued to have a small mean loss of BCVA (e.g., compared to preoperative, mean BCVA at 12 months for SZPRK was + 0.3, LASIK was +.21, ASPRK I was -0.11, and ASPRK II -0.31 (SZPRK versus ASPRK II, P = .0116). Predictability was better for PRK than LASIK at all follow-up intervals (e.g., for manifest refraction spherical equivalent +/- 1.0 diopters at 6 months, ASPRK I 42/62 eyes (68%) versus LASIK 29/72 eyes (40%), P = .0014%). Stability was slightly but insignificantly less in the LASIK eyes compared to PRK eyes. All visual outcome measures were better for eyes with preoperative myopia between -6 and -8.9 D compared with eyes with myopia between -9 and -12 D. No consistent differences in refractive outcomes or postoperative corneal haze were seen between aspherical and single-zone ablations; haze diminished over 12 months and was judged to be vision-impairing in only one ASPRK eye. Microkeratome and flap complications occurred in 4 eyes, resulting in delay of completion of the procedure in 3 eyes but not causing long-term impairment. CONCLUSIONS: Improvement in uncorrected visual acuity and return of best corrected visual acuity was more rapid for LASIK than PRK, but efficacy outcomes in the longer term through 12 months were similar for all treatment groups. LASIK eyes tended toward undercorrection with the nomogram employed in this study compared to PRK, but the scatter was similar, suggesting little difference between these procedures for most patients by 6 months and thereafter. No consistent advantage was demonstrated between aspherical and single-zone ablation patterns. Predictability was much better for all procedures for corrections of -6 to -8.9 D compared with -9 to -12 D. Sporadic loss of best corrected vision in the PRK eyes not found in the LASIK eyes and other measures of visual function require further study. (+info)

Clinical estimation of corneal endothelial pump function. (7/579)

PURPOSE: To develop a technique to estimate the corneal endothelial pump rate in human subjects. METHODS: Corneal hydration control is thought to be maintained by a pump-leak mechanism whereby the leak of solutes and fluid across the endothelial barrier into the stroma is, in the steady state, exactly balanced by the pumping of solutes and passive fluid transfer across the endothelium to the aqueous humor. Overall corneal hydration control can be measured from the rate at which the swollen cornea thins (deswells), and a measure of the leak can be obtained simultaneously from the endothelial permeability to fluorescein. From the pump-leak hypothesis, the deswelling rate is directly proportional to the pump rate and inversely proportional to the leak rate. The relative endothelial pump rate can be estimated as the product of the normalized deswelling rate and the normalized endothelial permeability. This procedure was used to obtain the relative endothelial pump rate in 41 patients with diabetes mellitus, 12 patients with long-term corneal transplants, 20 long-term wearers of contact lenses, and 19 normal volunteer subjects after the short-term administration of topical dorzolamide. RESULTS: The relative endothelial pump rate did not differ significantly from that of control subjects in diabetics, in contact lens wearers, and after dorzolamide administration, but was markedly decreased in the patients with corneal transplants, despite a reduction in permeability (reduced leak). CONCLUSIONS: This method allows the estimation of both the barrier and pump arms of corneal endothelial function and should be useful in the investigation of causes and mechanisms of functional endothelial insufficiency. (+info)

A new surgical technique for deep stromal, anterior lamellar keratoplasty. (8/579)

AIMS: To describe a new surgical technique for deep stromal anterior lamellar keratoplasty. METHODS: In eye bank eyes and sighted human eyes, aqueous was exchanged by air, to visualise the posterior corneal surface--that is, the "air to endothelium" interface. Through a 5.0 mm scleral incision, a deep stromal pocket was created across the cornea, using the air to endothelium interface as a reference plane for dissection depth. The pocket was filled with viscoelastic, and an anterior corneal lamella was excised. A full thickness donor button was sutured into the recipient bed after stripping its Descemet's membrane. RESULTS: In 25 consecutive human eye bank eyes, a 12% microperforation rate was found. Corneal dissection depth averaged 95.4% (SD 2.7%). Six patient eyes had uneventful surgeries; in a seventh eye, perforation of the lamellar bed occurred. All transplants cleared. Central pachymetry ranged from 0.62 to 0.73 mm. CONCLUSION: With this technique a deep stromal anterior lamellar keratoplasty can be performed with the donor to recipient interface just anterior to the posterior corneal surface. The technique has the advantage that the dissection can be completed in the event of inadvertent microperforation, or that the procedure can be aborted to perform a planned penetrating keratoplasty. (+info)

... , also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal collagen cross-linking may delay or eliminate the need for corneal transplantation in keratoconus and post-LASIK ... Different types of contact lenses may be used to delay or eliminate the need for corneal transplantation in corneal disorders. ... However, in most of the cases where corneal transplantation is recommended, PTK would not be effective. In corneal disorders ...

https://en.wikipedia.org/wiki/Corneal_transplantation

It is used in a corneal transplantation procedure (also corneal grafting) whereby the whole, or part, of a cornea is replaced. ... Traditionally, the most common procedure for corneal transplantation was penetrating keratoplasty whereby an entire corneal ... n.d.). Corneal transplantation. Retrieved from https://www.keratoconus.org.au/treatments/corneal-transplantation/ National ... Diseases transmissible via corneal transplantation include bacterial infection and fungal infection, rabies, Hepatitis B and ...

https://en.wikipedia.org/wiki/Corneal_button

Corneal transplantation is often required. Corneal dystrophy Groenouw A. Knötchenförmige Hornhauttrübungen (noduli corneae). ... Macular corneal dystrophy is very common in Iceland and accounts for almost one-third of all corneal grafts performed there. ... Macular corneal dystrophy, also known as Fehr corneal dystrophy named for German ophthalmologist Oskar Fehr (1871-1959), is a ... Macular corneal dystrophy is inherited in autosomal recessive fashion and is thought to be caused by the lack or abnormal ...

https://en.wikipedia.org/wiki/Macular_corneal_dystrophy

Corneal transplantation Corneal ulcer Corneal button "WHO -Priority eye diseases". www.who.int. Archived from the original on ... Keratoplasty also known as corneal transplantation is the main treatment option for visual improvement in corneal opacity. In ... The term corneal blindness is commonly used to describe blindness due to corneal opacity. Depending on the density, corneal ... "Foldable artificial cornea may provide another option for corneal transplantation". www.healio.com. "Corneal Blindness". " ...

https://en.wikipedia.org/wiki/Corneal_opacity

Corneal transplantation is not usually indicated during corneal hydrops. The person experiences pain and a sudden severe ... Corneal hydrops might be caused by a tear in the recently discovered Dua's layer, a 15 micron thick layer between the corneal ... Corneal hydrops is an uncommon complication seen in people with advanced keratoconus or other corneal ectatic disorders, and is ... and understanding of corneal dystrophies and pathologies, such as acute hydrops. "Acute Corneal Hydrops". University of ...

https://en.wikipedia.org/wiki/Corneal_hydrops

In this case, a corneal transplantation may be needed. There have been many cases in which teenage patients have had the ... Lattice corneal dystrophy type is a rare form of corneal dystrophy. It has no systemic manifestations, unlike the other type of ... Recurrent corneal erosions may precede the corneal opacities and even appear in individuals lacking recognizable stromal ... Although people with lattice dystrophy have an excellent chance for a successful corneal transplantation, the disease may also ...

https://en.wikipedia.org/wiki/Lattice_corneal_dystrophy

Niederkorn, Jerry Y. (2017-01-27). "Corneal Transplantation and Immune Privilege". International Reviews of Immunology. 32 (1 ... Niederkorn, Jerry Y. (2013-01-13). "Corneal Transplantation and Immune Privilege". International Reviews of Immunology. 32 (1 ... Compared to skin allografts, which are rejected in almost 100% of cases, corneal allografts survive long-term in 50-90% of ... In another study on type II diabetic and obese mice, the transplantation of microencapsulated Sertoli cells in the subcutaneous ...

https://en.wikipedia.org/wiki/Immune_privilege

For services to Corneal Transplantation. Catherine Elizabeth Jane Arnold, lately H.M. Ambassador, Ulaanbaatar, Mongolia. For ... For services to Complex Reconstructive Hand Surgery including Hand Transplantation. Colin Jeffery Kelsey, Head of Emergency ...

https://en.wikipedia.org/wiki/2019_New_Year_Honours

Corneal transplantation is a management option when there is severe corneal melting or perforation although one possible ... Grade I refers to corneal thinning, grade II describes impending corneal perforation, and grade III is corneal perforation with ... Deshmukh, Rashmi; Stevenson, Louis J.; Vajpayee, Rasik B. (2020). "Techniques of noncircular corneal transplantation". Current ... The corneal epithelium consists of five to six layers of cells with a total thickness of around 0.52mm. The cornea thickens to ...

https://en.wikipedia.org/wiki/Peripheral_ulcerative_keratitis

Human corneal transplantation (keratoplasty) had been attempted with little or no success throughout the 1800s using both ... Zirm - Die erste geglückte Organtransplantation - 1905 at www.drzirm.org Centennial review of corneal transplantation. (Clin ... "Centennial review of corneal transplantation". Clinical and Experimental Ophthalmology. 33 (6): 642-57. doi:10.1111/j.1442- ... Zirm 's method remains the basis for repairing corneal damage. Zirm played the violin and in his limited spare time studied ...

https://en.wikipedia.org/wiki/Eduard_Zirm

"Centennial review of corneal transplantation." Clin Experiment Ophthalmol. 2005 Dec;33(6):642-57. PMID 16402960. Finucane, ... "History of pancreas transplantation", by Dr. David E. R. Sutherland and Dr. Carl G. Groth, in Pancreas, Islet and Stem Cell ... Moran, W. Reed (March 6, 2001). "Mandy Patinkin saves sight with corneal transplants". USA Today. Retrieved October 26, 2011. " ... National Kidney Foundation Milestones in Organ Transplantation Terplan, Martin. Centenary of first successful human transplant ...

https://en.wikipedia.org/wiki/List_of_organ_transplant_donors_and_recipients

Global Survey of Corneal Transplantation and Eye Banking. JAMA Ophthalmol. 2016;134(2):167-173. doi:10.1001/jamaophthalmol. ... Corneal transplant surgery can cure blindness caused by corneal disease. However, there is a global shortage of corneal ... doi:10.1503/cmaj.109-4517 Hidetaka, Hara; Cooper, David KC (2011). "Xenotransplantation: the future of corneal transplantation ... With regard to corneal donations, the five-year deferral policy in the United States and the similar 12-month deferral policy ...

https://en.wikipedia.org/wiki/Blood_donation_restrictions_on_men_who_have_sex_with_men

and applied to corneal tissue transplantation. His work culminated in the development of chemical shift NMR Microscopy, which ... and corneal metabolism in order to create new and improved methods of tissue preservation for improved tissue transplantation. ... "Dynamic monitoring of corneal carbohydrate metabolism using high-resolution deuterium NMR spectroscopy", Exp Eye Res., 47 (2): ... "Corneal epithelium following intraepikeratophakia", J Cataract Refract Surg, 17 (4): 460-5, doi:10.1016/s0886-3350(13)80852-8, ...

https://en.wikipedia.org/wiki/James_B._Aguayo-Martel

"VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. ... Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (2016-05-15). "Alloimmunity and Tolerance in Corneal Transplantation". The ... "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The ... developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy. 1981 - National ...

https://en.wikipedia.org/wiki/Reza_Dana

They have also improved corneal transplantation through innovations in DLEK (deep lamellar endothelial keratoplasty) and DSEK ( ... Samanlego, Chiles Aedam R. (29 April 2014). "New therapeutic dimensions in corneal transplantation". Eyeworld Daily News. p. 20 ... innovative corneal transplant surgeon Peter Veldman, corneal transplant surgeon and Associate Professor of Ophthalmology and ...

https://en.wikipedia.org/wiki/Legacy_Devers_Eye_Institute

... such patients finally require corneal transplantation. In case of prolonged or chronic eye pain, especially neuropathic eye ... Chern KC, Meisler DM, Wilhelmus KR, Jones DB, Stern GA, Lowder CY (January 1996). "Corneal anesthetic abuse and Candida ... topical anesthetics can cause severe and irreversible damage to corneal tissues and even loss of the eye. The abuse of topical ... often ending up with irreversible corneal damage or even destruction (which is a vicious cycle and causes more pain). Often, ...

https://en.wikipedia.org/wiki/Topical_anesthetic

"Spencer Eye Hospital to resume corneal transplantation". The Express Tribune. 2018-12-19. Retrieved 2022-05-11. "Corneal ... In 2019, the hospital resumed cornea transplantation after a gap of 12 years. "Spencer Eye Hospital, Karachi". heritage. ...

https://en.wikipedia.org/wiki/Spencer_Eye_Hospital

Parikumar, P (2018). "Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy". Am ... In addition, excessive corneal hydration can result in edema of the corneal epithelial layer, which creates irregularity at the ... Historically, penetrating keratoplasty, or full thickness corneal transplantation, was the treatment of choice for irreversible ... In cases in which irreversible corneal endothelial failure develops, severe corneal edema ensues, and the only effective remedy ...

https://en.wikipedia.org/wiki/Corneal_endothelium

Recurrence within a few years occurs in all patients following corneal transplantation. Soft contact lenses are effective in ... Gelatinous drop-like corneal dystrophy, also known as amyloid corneal dystrophy, is a rare form of corneal dystrophy. The ... Media related to Gelatinous droplike corneal dystrophy at Wikimedia Commons v t e (Articles with short description, Short ... The main pathological features in this dystrophy are mulberry-shaped gelatinous masses beneath the corneal epithelium. Patients ...

https://en.wikipedia.org/wiki/Gelatinous_drop-like_corneal_dystrophy

In more severe cases, a partial or complete corneal transplantation may be considered. However, it is common for the dystrophy ... This cloudiness, or opacity, causes the corneal epithelium to become elevated, which leads to corneal opacities. The corneal ... Reis-Bücklers corneal dystrophy is a rare, corneal dystrophy of unknown cause, in which the Bowman's layer of the cornea ... These recurrent painful corneal epithelial erosions often begin as early as 1 year of age. With time, the corneal changes ...

https://en.wikipedia.org/wiki/Reis–Bucklers_corneal_dystrophy

The unit specialises in corneal transplantation surgery and oculoplastics. The eye bank, previously named the National Eye Bank ... The Corneo Plastic and Ophthalmology unit continues to perform corneal transplantation, lamellar grafts, and stem cell ... transplantation for occular surface rehabilitation. Raman Malhotra, consultant ophthalmologist at the hospital, discovered a ...

https://en.wikipedia.org/wiki/Queen_Victoria_Hospital

Management of CHED primarily involves corneal transplantation. The age that corneal transplantation is required is variable, ... Congenital hereditary corneal dystrophy (CHED) is a form of corneal endothelial dystrophy that presents at birth. CHED was ... Posterior polymorphous corneal dystrophy (for the condition previously referred to as CHED1) Corneal dystrophy Bowes Hamill, M ... The corneal stroma becomes severely disorganised; the lamellar arrangement of the fibrils becomes disrupted.[citation needed] ...

https://en.wikipedia.org/wiki/Congenital_hereditary_endothelial_dystrophy

Corneal transplantations are the major focus of the department. Penetrating keratoplasty Anterior and posterior lamellar ... It is an internationally renown centre for corneal transplantation, ocular surface disease and management of associated ... It participates in a number of international multicentre trials on Dry eye and tear substitutes Corneal transplantation ... Since then diagnosis and management of corneal disease has been the focus of the department. Since 2011, the Universitäts- ...

https://en.wikipedia.org/wiki/Universitäts-Augenklinik_Düsseldorf

Kidney transplantation and Corneal transplantation are conducted in the Hospital. (Articles lacking sources from December 2012 ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ...

https://en.wikipedia.org/wiki/S_Nijalingappa_Medical_College,_HSK_(Hanagal_Shree_Kumareshwar)_Hospital_and_Research_Centre

Kidney transplantation and Corneal transplantation are conducted in the Hospital. JSS Hospital is the first Hospital to conduct ... Its main purpose is to receive donor bodies for corneal transplantation for the blind, as well as for research purposes and the ... Renal Transplantation outside Bangalore in the state of Karnataka. JSS Medical College - Home JSS University - Medical College ...

https://en.wikipedia.org/wiki/JSS_Medical_College

"Corneal Transplantation - procedure, recovery, blood, removal, complications, adults, time, infection". www.surgeryencyclopedia ... Lasers may be used to treat nonrefractive conditions (e.g. to seal a retinal tear). Laser eye surgery or laser corneal surgery ... Keratomilleusis is a method of reshaping the corneal surface to change its optical power. A disc of the cornea is shaved off, ... Intracorneal rings or corneal ring segments Implantable contact lenses Presbyopia reversal Anterior ciliary sclerotomy Scleral ...

https://en.wikipedia.org/wiki/Eye_surgery

Kidney transplantation and corneal transplantation are conducted in the hospital. admin. "BLDE(Deemed to be University) - ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ...

https://en.wikipedia.org/wiki/Shri_B._M._Patil_Medical_College

Corneal transplantation#Endothelial keratoplasty Corneal transplantation#DSEK/DSAEK/DMEK "Descemet Membrane Endothelial ... The two corneal layers which are exchanged are the Descemet's membrane and the corneal endothelium. The person's corneal tissue ... Corneal dystrophy involving the corneal endothelial layer, e.g.: Fuchs' endothelial dystrophy Posterior polymorphous corneal ... v t e v t e (Eye procedures, Corneal transplantation, Medical procedures, Eye surgery, Ophthalmology, All stub articles, ...

https://en.wikipedia.org/wiki/Descemet_membrane_endothelial_keratoplasty

Surgery in the form of corneal transplantation (penetrating keratoplasty) is usually necessary to save the eye. Corneal ulcers ... surgical intervention by an ophthalmologist with corneal transplantation may be required to save the eye. In all corneal ulcers ... In ophthalmology, a corneal ulcer usually refers to having an infectious cause while the term corneal abrasion refers more to ... Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ...

https://en.wikipedia.org/wiki/Corneal_ulcer

Suboptimal vision caused by corneal dystrophy usually requires surgical intervention in the form of corneal transplantation. ... Corneal dystrophies are a group of diseases that affect the cornea in dogs. Corneal dystrophy in dogs usually does not cause ... Corneal endothelial dystrophy is an age-related change that affects the inner layer of the corneal, the endothelium. Leakage of ... It can develop into a corneal ulcer. Siberian Husky - occurs at five months to two years of age and is gray and oval. ...

https://en.wikipedia.org/wiki/Corneal_dystrophies_in_dogs

One case report describes an HTLV-1 infected woman who developed chronic refractory eczema, corneal injury and adult T cell ... She was subsequently treated with allogenic stem cell transplantation and had complete resolution of symptoms. One year post- ... Allogenic bone marrow transplantation has been investigated in the treatment of HTLV-1 disease with varied results. ...

https://en.wikipedia.org/wiki/Human_T-lymphotropic_virus_1

Later he did Corneal transplantation and could partially recover vision in one of his eyes. George was campus placed in the ...

https://en.wikipedia.org/wiki/George_Thengummoottil

Bone-marrow transplantation and hematopoietic stem-cell transplantation (HSCT) have been used as treatments in some studies. ... Unlike MPS I, corneal clouding is not associated with this disease. Hunter syndrome may present with a wide variety of ... While transplantation has provided benefits for many organ systems, it has not been shown to improve the neurological symptoms ... Guffon, N (May 2009). "Bone marrow transplantation in children with Hunter syndrome: outcome after 7 to 17 years". Journal of ...

https://en.wikipedia.org/wiki/Hunter_syndrome

A second case of CJD associated with a corneal transplant was reported without details. In 1977, CJD transmission caused by ... "Risk of Creutzfeldt-Jakob disease transmission by ocular surgery and tissue transplantation". Eye. 23 (10): 1926-30. doi: ... corneal grafts, dural grafts, or electrode implants and human growth hormone. It can be familial (fCJD); or it may appear ... and corneal and meningeal transplants. Variant Creutzfeldt-Jakob disease (vCJD) is a type of acquired CJD potentially acquired ...

https://en.wikipedia.org/wiki/Creutzfeldt–Jakob_disease

Aya later discovers that she also possesses Maya's mitochondria, transferred to her body during the corneal transplantation, ...

https://en.wikipedia.org/wiki/Aya_Brea

... contained a then-unusual provision that his eyes be donated to the Estelle Doheny Eye Foundation for corneal transplantation or ...

https://en.wikipedia.org/wiki/Tyrone_Power

Chen, Michael; Kunselman, Allen; Christy, Stetter; Sadeer, Hannush; Benjamin, Roberts (2017-10-27). "Corneal transplantation at ...

https://en.wikipedia.org/wiki/Jason_Fader

In a single case report, a corneal transplantation was performed for concurrent keratoconus, and at 10 years follow-up there ... Fleck corneal dystrophy, also known as Francois-Neetens speckled corneal dystrophy, is a rare form of corneal dystrophy. It is ... Klintworth GK (2009). "Corneal dystrophies". Orphanet J Rare Dis. 4: 7. doi:10.1186/1750-1172-4-7. PMC 2695576. PMID 19236704 ...

https://en.wikipedia.org/wiki/Fleck_corneal_dystrophy

Symptoms but no corneal involvement Grade 2 MODERATE - Symptoms with photophobia but no corneal involvement Grade 3 SEVERE - ... as well as amniotic membrane transplantation to enhance re-epithelialisation. Recently treatment with tacrolimus ointment (0.1 ... Corneal involvement in VKC may be primary or secondary due to extension of limbal lesions. Vernal keratopathy includes 5 types ... Associated symptoms include mild photophobia in case of corneal involvement, lacrimation, stringy discharge and heaviness of ...

https://en.wikipedia.org/wiki/Vernal_keratoconjunctivitis

... a non-governmental organization established in 1961 has provided over 60,000 corneas for corneal transplantation, for patients ... Australian Organ Donor Register Organ transplantation in Israel Organ transplantation in China MOHAN Foundation Sri Lanka Eye ... Wicks, Mona Newsome (April 25, 2000). "Brain Death and Transplantation: The Japanese". Medscape Transplantation. Retrieved ... "The Transplantation of Human Organs (Amendment) Bill, 2011". Act No. 136-C of 2009 (PDF). Archived (PDF) from the original on ...

https://en.wikipedia.org/wiki/Organ_donation

He was the son of Arthur von Hippel (1841-1916), a pioneer in corneal transplantation, and an uncle to German-American ...

https://en.wikipedia.org/wiki/Eugen_von_Hippel

However, residual scarring cannot be avoided which can result in long term visual impairment and corneal transplantation is not ... is corneal scarring due to chronic inflammation of the corneal stroma. Interstitial means space between cells i.e. corneal ... The corneal scarring is the end result of the initial invasion of blood vessels into the corneal stroma as part of the ... Since normal corneal tissue should be avascular (no blood vessel) and therefore clear to allow light to pass, the presence of ...

https://en.wikipedia.org/wiki/Interstitial_keratitis

Liver transplantation has proven to be effective for ATTR familial amyloidosis due to Val30Met mutation. In 2011 the European ... July 1996). "Lattice corneal dystrophy type II associated with familial amyloid polyneuropathy type IV". Ophthalmology. 103 (7 ... July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ...

https://en.wikipedia.org/wiki/Familial_amyloid_neuropathy

Kato, T; Kure, T; Chang, JH; Gabison, EE; Itoh, T; Itohara, S; Azar, DT (2001). "Diminished corneal angiogenesis in gelatinase ... Rafii, S; Lyden, D (2003). "Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration". ... Both enzymes inhibit bFGF induced vascularization in the corneal pocket assay and inhibit VEGF induced angiogenesis in the ... For example, MMP-2 knockout mice develop normally but display significant inhibition of corneal angiogenesis. Numerous ...

https://en.wikipedia.org/wiki/Proteases_in_angiogenesis

2016), and lattice corneal dystrophy type I (LCDI) (Courtney et al. 2014). RNAi intersects with a number of other pathways; it ... Traditionally, liver transplantation has been the standard treatment for hereditary transthyretin amyloidosis, however its ... effectiveness may be limited by the persistent deposition of wild-type transthyretin amyloid after transplantation. There are ...

https://en.wikipedia.org/wiki/Small_interfering_RNA

... polar arteries in renal transplantation and in living liver donor transplantation). Microsurgery has been used to treat several ... Cataract surgery, corneal transplants, and treatment of conditions like glaucoma are performed by ophthalmologists. Urologists ... The first human microsurgical transplantation of the second toe to thumb was performed in February 1966 by Dr. Dong-yue Yang ... Buncke H, Buncke C, Schulz W (1966). "Immediate Nicoladoni procedure in the Rhesus monkey, or hallux-to-hand transplantation, ...

https://en.wikipedia.org/wiki/Microsurgery

... (born in Chicago, USA) is a Greek-American eye surgeon specializing in corneal transplantation, ... customized laser refractive surgery and corneal cross-linking propagation and most innovations, reducing corneal transplants ... "Combining corneal crosslinking and PRK shows increasingly good results in keratoconus". American Academy of Ophthalmology. 2010 ... Vinciguerra, Paolo; Albé, Elena; Frueh, Beatrice E.; Trazza, Silvia; Epstein, Daniel (2012-09-01). "Two-Year Corneal Cross- ...

https://en.wikipedia.org/wiki/Anastasios_John_Kanellopoulos

His medical reputation was the result of his extensive studies on corneal diseases and transplantation biology. Khodadoust died ... was an Iranian eye surgeon specializing in corneal transplantation, in whose honor the Khodadoust rejection line is named. He ...

https://en.wikipedia.org/wiki/Ali_Asghar_Khodadoust

... the most common treatment for which is allograft cornea transplantation. However, donor corneal grafts are in short supply and ... "Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering". Biomaterials. 31 ( ...

https://en.wikipedia.org/wiki/Arginylglycylaspartic_acid

"Amniotic Membrane Transplantation in Acute Phase of Toxic Epidermal Necrolysis with Severe Corneal Involvement". Ophthalmology ...

https://en.wikipedia.org/wiki/Thygeson's_superficial_punctate_keratopathy

He went on to complete his post-doctoral fellowship training in corneal transplantation, cataract surgery and laser refractive ... He performs complex corneal collagen and cross-linking (CXL) procedures for keratoconus patients, combined with excimer laser ... In 2015, Wallerstein and Cohen launched a new laser vision procedure called Laser PresbyVision™, a corneal-based treatment ...

https://en.wikipedia.org/wiki/Avi_Wallerstein

Bascom Palmer faculty introduced limbal stem cell transplantation therapy, which now can prevent potentially blinding corneal ... Retina and Vitreous Diseases and Surgery Glaucoma Corneal and external diseases Laser Vision Center treatments Neuro- ...

https://en.wikipedia.org/wiki/Bascom_Palmer_Eye_Institute

... corneal transplantation, skin grafting, dental implants, hysterectomy, various types of cysts and "rare tumors", and talus bone ...

https://en.wikipedia.org/wiki/Victor_Gomoiu

His specialty is laser vision correction, cataract and lens surgery, and corneal transplantation. Sutton graduated in medicine ... In 2010, Sutton became the inaugural Professor of Corneal and Refractive Surgery at the Sydney Eye Hospital and the University ... Retrieved 2018-09-19 A user's manual for people with Keratoconus: from glasses to corneal grafts and everything in between. ... "New Invention for Corneal Ulcers wins $1.1M Grant from NSW Medical Device Fund - RANZCO.edu". Archived from the original on 21 ...

https://en.wikipedia.org/wiki/Gerard_Sutton_(ophthalmologist)

... untreated or partially treated infectious keratitis and requires surgical intervention in the form of corneal transplantation. ... It is a dry looking corneal ulcer with satellite lesions in the surrounding cornea. Usually associated with fungal ulcer is ... from the corneal scraping. Recent advances have been made in PCR ref 3./immunologic tests which can give a much quicker result ... Corneal perforation can occur in patients with ...

https://en.wikipedia.org/wiki/Fungal_keratitis

... and part of the Libin Cardiovascular Institute of Alberta Multiple transplantation such as kidney, pancreas, corneal and tissue ...

https://en.wikipedia.org/wiki/Foothills_Medical_Centre

His PhD thesis on corneal permeability introduced the pump-leak hypothesis for the corneal endothelium. At the Institute of ... It has also become valuable for screening donor corneas for transplantation. Together with a long list of fellows he developed ... routine tool for evaluating the corneal endothelium in health and disease. ... Ophthalmology in London, he worked on the explanation of the physical basis of corneal transparency, aqueous humor dynamics, ...

https://en.wikipedia.org/wiki/David_M._Maurice

Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada)-dedicated to using leading-edge science to save and improve lives around the world. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge.. ...

https://www.merckmanuals.com/en-ca/home/multimedia/quiz/corneal-transplantation

Return to Article Details Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective ...

http://mji.ui.ac.id/journal/index.php/mji/article/view/3849/2006

... also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal ... Corneal transplantation. Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or ... Cornea transplantation surgery. Shannon Wong, MD 10-2013.. Source: Shannon Wong, MD ... diseased cornea is replaced by donated corneal tissue (the graft). When the entire cornea is replaced it is known as ...

https://surgicaltechedu.org/cornealtransplantation/

Best Corneal Transplantation (keratoplasty) in Iran at the best price for you to restore your vision and improve the appearance ...

https://exonmed.co/en/tags/Corneal-Transplantation-in-Iran.html

... treatment that is currently being investigated for a variety of diseases could be useful in corneal transplantation, where ... In fact, the formation of lymphatic vessels after corneal transplantation is purported to be a major mechanism through which ... treatment that is currently being investigated for a variety of diseases could be useful in corneal transplantation, where ... treatment that is currently being investigated for a variety of diseases could be useful in corneal transplantation, where ...

https://europe.ophthalmologytimes.com/view/gene-silencing-may-help-corneal-transplantation

Corneal edema or infection that does not respond to other treatments Types of Keratoplasty. There are several types of corneal ... Corneal Transplant Surgery in Dayton, Springboro & Surrounding Areas. At CVP Physicians Dayton, our fellowship-trained corneal ... Healthy corneal tissues from deceased donors are typically widely available. Your surgeon will give you detailed preoperative ... Keratoplasty is a surgical procedure to replace all or part of the cornea with donated corneal tissue. Your cornea is the clear ...

https://www.cvpdaytoneyedoctors.com/cornea/keratoplasty/

AMT following High-Risk Corneal Transplantation. AMT following High-Risk Corneal Transplantation ... Amniotic Membrane Transplantation for Corneal Indications. Overview. Superficial corneal opacity after AMT ... Even if corneal transplantation is needed, its success is promoted if performed in an eye that received AMT to reduce ... Our strategy for corneal surface reconstruction includes amniotic membrane transplantation (AMT). There are two modes for ...

https://www.osref.org/medical-education-materials/amniotic-membrane-transplantation-for-corneal-indications/

Therapeutic assistance / corneal transplantation A believer had a traumatic accident during his work, which led to damage to ...

https://www.ico.org.ae/en/project-2622?categoryId=0

In two patients, the infected eye was enucleated; 12 patients underwent corneal transplantation. ... recurrent corneal epithelial breakdown; and (4) a corneal lesion refractory to the usual medications. The diagnosis can be ... corneal lesions were attributed to autoimmune disease. Acanthamoeba keratitis was diagnosed by examination of stained corneal ... Twenty-two (90%) of the 24 patients were initially diagnosed as having corneal herpes simplex virus (HSV) infections; in the ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00000753.htm

Corneal transplantation is recommended for:. *Severe corneal infection, injury, damage, or scarring ...

https://medlineplus.gov/ency/presentations/100082_2.htm

Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors. Am J Ophthalmol 2021; ... Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors Citation:. Roldan AM, Zebardast N, Pistilli M, ... Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors. Am J Ophthalmol 2021; ... PURPOSE: To estimate the incidence of corneal endothelial transplantation and identify risk factors among patients with non- ...

https://eye.hms.harvard.edu/publications/corneal-endothelial-transplantation-uveitis-incidence-and-risk-factors

Corneal cross-linking is the first medical therapy available in the US to slow disease progress. ... Other options have included corneal implants and corneal transplantation.. The new treatment works by strengthening the cross- ... Artificial Intelligence and Corneal Diseases * Perioperative Care of the Patient With eye Pathologies Undergoing Nonocular ... Corneal collagen cross-linking using UVA light with riboflavin photosensitizer is the first medical therapy available in the ...

http://www.medscape.com/viewarticle/749720

Cryptococcal endophthalmitis after corneal transplantation. N Engl J Med. 1978;298:825-6. DOIPubMedGoogle Scholar ... Cryptococcus albidus keratitis after corneal transplantation. Cornea. 2005;24:882-3. DOIPubMedGoogle Scholar ... Cryptococcosis in solid organ transplantation-Guidelines from the American Society of Transplantation Infectious Diseases ... Survival of a patient transplanted with a kidney infected with Cryptococcus neoformans. Transplantation. 1971;11:428-9. DOI ...

https://wwwnc.cdc.gov/eid/article/26/6/19-1765_article

This form of corneal degeneration can result from a variety of causes, either systemic or local, with visual acuity decreasing ... formed by the precipitation of calcium salts on the corneal surface (directly under the epithelium). ... Corneal calcification after amniotic membrane transplantation. Br J Ophthalmol. 2003 May. 87(5):587-91. [QxMD MEDLINE Link]. ... on the underside of the corneal epithelium. [1] This corneal degeneration can result from a variety of causes, either systemic ...

http://emedicine.medscape.com/article/1194813-overview

Erratum: Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study * Vega Casalita ... Casalita V, Nora RLD, Edwar L, Susiyanti M, Sitompul R. Erratum: Amniotic membrane transplantation for infectious corneal ulcer ... Casalita V, Nora RLD, Edwar L, Susiyanti M, Sitompul R. Amniotic membrane transplantation for infectious corneal ulcer ... Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study , Medical Journal of ...

http://mji.ui.ac.id/journal/index.php/mji/article/view/5430

Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model. ... Conclusions: Direct transplantation of cultured human CE cells and immortalized HCEC-12 to bare posterior corneal stroma ... Purpose: To test the feasibility of a cell therapy approach to treat corneal endothelial (CE) disorders using an in vitro model ... Stromal thickness reduced from 1218 ± 153 μm to 458 ± 90 μm (63% ± 6%, P = 0.001) after cell transplantation in group 3 and ...

https://www.alchimiasrl.com/en/feasibility-study-of-human-corneal-endothelial-cell-transplantation-using-an-in-vitro-human-corneal-model/

Corneal transplantation. * Laser refractive surgery. * Presbyopic correction. * Intraocular lenses. * Contact lens and contact ...

https://www.urmc.rochester.edu/eye-institute/clinical-trials.aspx

Paradigm Shifts in Corneal Transplantation. Donald TH Tan, Arundhati Anshu, Jodhbir S Mehta 23 December 2021. ...

https://annals.edu.sg/tag/penetrating-keratoplasty/

Corneal stem cell transplantation. One arm of our research program involves identifying, isolating and cultivating human and ... Mapping the dynamics of corneal stem cells during aging and after wounding and transplantation ... Corneal Wound Healing. The third arm of our research program focuses on understanding the mechanisms of wound-healing in the ... Developing diagnostic tools for patients with corneal disease. Another area we are interested in pursuing is to develop ...

https://www.unsw.edu.au/staff/nick-di-girolamo

Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. We reported the case of a 65-year-old male ... Therefore, corneal perforation can occur as the presenting manifestation of ocular GVHD. Regular ophthalmological examinations ... and lacrimal punctal occlusion surgery resulted in the successful resolution of the corneal perforation with satisfactory ... patient who developed corneal perforation sequentially in both eyes 3 years after receiving HSCT. Conservative treatment with ...

https://lidsen.com/journals/transplantation/transplantation-06-03-164

Corneal Transplantation E4.540.225 E4.540.825.374. Coronary Aneurysm C14.907.553.470.250.250 C14.907.585.250.250. Coronary ... Replaced for 2008 by Corneal Surgery, Laser). Keratectomy, Photorefractive, Excimer Laser. E4.416.237.500 E2.594.480.875. ...

https://decs.bvs.br/P/mnchg2008.htm

Corneal collagen cross-linking, known as CXL, the first and only treatment to date that is proven to stop Keratoconus, KCN, ... Severe cases were treated with corneal transplantation.. Navy Capt. (Dr.) John Cason, prior ophthalmology specialty leader and ... Corneal Collagen Cross Linking in the Military a Game Changer Corneal collagen cross-linking, known as CXL, the first and only ... In 2016, the Food and Drug Administration approved corneal collagen cross-linking, known as CXL. This is the first and only ...

https://www.health.mil/News/Articles/2022/05/27/Corneal-Collagen-Cross-linking-in-the-Military-A-Game-Changer?type=All&page=1

Corneal thickness measurements in the PEX group were statistically significantly different between Pentacam and OCT Casia: ... i,Conclusion.,/i, The central corneal thickness in eyes with PEX syndrome measured with three different independent methods is ... nasal and temporal corneal zones were statistically significantly different (,span class=inline_break,,svg xmlns:xlink=http ... higher than that in the non-PEX group, and despite variable peripheral corneal thickness, this one parameter is still crucial ...

https://www.hindawi.com/journals/jhe/2017/4315238/

Treatment of severe ocular-surface disorders with corneal epithelial stem cell transplantation. Alfonso EC. Alfonso EC. Arch ... Corneal biopsy in the management of progressive microbial keratitis. Alexandrakis G, Haimovici R, Miller D, Alfonso EC. ...

https://pubmed.ncbi.nlm.nih.gov/?term=Alfonso+EC&cauthor_id=11296013

Corneal Surgery. *Corneal Transplant. *Corneal Transplantation (penetrating And Lamellar Keratoplasty And Dsaek) ...

https://my.clevelandclinic.org/staff/23120-bryan-roth

After corneal transplantation, the residual eyeballs still maintained their original shapes. We used autoclaved ophthalmic ... Then, the eye tissue leftovers were harvested after dissection of the corneal graft and preserved at 4°C in DMEM-F12 media ( ...

https://www.frontiersin.org/articles/10.3389/fncel.2021.786020/full

Orthotopic corneal transplantation in mice-evidence that the immunogenetic rules of rejection do not apply. Transplantation ... Williams KA, Muehlberg SM, Lewis RF, et al. How successful is corneal transplantation? A report from the Australian Corneal ... Penetrating corneal transplantation in the inbred rat: a new model. Invest Ophthalmol Vis Sci 1985;26:23-30. ... We have performed series of murine corneal transplantations in the fully mismatched pairing of C57BL/10 (H-2b) donor to BALB/c ...

https://bjo.bmj.com/content/86/1/108

Corneal Transplant 10 more treatments 2 other locations in New South Wales for Marsden Eye Specialists - Parramatta ...

https://www.whatclinic.com/eye-clinics/australia/new-south-wales

He conducted his ophthalmic surgical training in Newcastle upon Tyne, UK and his corneal subspecialty training at Moorfields ...

https://www.expatwoman.com/abu-dhabi/health-fitness/client/mediclinic-airport-road-hospital/meet-dr-hamed-mofeez-anwar

During January 8-14, 1998, six of eight patients undergoing elective intraocular surgery at a Veterans Affairs medical center (VAMC) in St. Louis, Missouri, developed corneal endothelial decompensation (corneal edema and opacification) less than or equal to 24 hours after surgery. (cdc.gov)

Keratoplasty is a surgical procedure to replace all or part of the cornea with donated corneal tissue. (cvpdaytoneyedoctors.com)
Time-to-event analysis was used to estimate the incidence of corneal endothelial transplantation (CET), including penetrating keratoplasty, Descemet stripping endothelial keratoplasty, or Descemet Membrane Endothelial Keratoplasty procedures. (harvard.edu)
3 Heterotopic keratoplasty in the mouse was first described in the early 1980s 4- 6 while the first reports of orthotopic murine corneal grafts were published a decade later. (bmj.com)
Accordingly, researchers using the rat and mouse orthotopic keratoplasty models have developed grading systems for corneal graft rejection which incorporate each of these features-cellular infiltration, oedema, opacity, and new vessel ingrowth-and produce an aggregate score. (bmj.com)
Predictors of Receiving Keratoplasty for Fuchs' Endothelial Corneal Dystrophy among Medicare Beneficiaries. (medscape.com)
With the development of new surgical techniques, instrumentation and pharmacological advances, corneal transplant procedures can undergo changes directly in the clinical profile of patients with the indication for penetrating keratoplasty technique. (bvsalud.org)

The posterior stroma of decompensated corneas was seeded with immortalized human corneal endothelial cells (HCEC-12) in group 3 and passage 0 primary human CE cells in group 4 corneas. (alchimiasrl.com)
The loss or dysfunction of human corneal endothelial cells (hCEnCs) is a leading cause of blindness due to corneal failure. (mdpi.com)
Zhu Q, Zhu Y, Tighe S, Liu Y, Hu M. Engineering of Human Corneal Endothelial Cells In Vitro . (medsci.org)
Human corneal endothelial cells are responsible for controlling corneal transparency, however they are notorious for their limited proliferative capability. (medsci.org)
Recently, we have reported effective expansion of human corneal endothelial cells by reprogramming the cells into progenitor status through use of p120-Kaiso siRNA knockdown. (medsci.org)
Human corneal endothelial cells (HCECs) are embryologically derived from cranial neural crest progenitor cells (reviewed in [ 1 ]) and form a single monolayer of hexagonal cells lining the posterior cornea [ 2 ]. (medsci.org)

Band keratopathy is characterized by the appearance of an opaque white band of variable density across the central cornea, caused by the precipitation of calcium salts, primarily hydroxyapatite, on the underside of the corneal epithelium. (medscape.com)
In the second procedure, the central corneal epithelium will be removed using a surgical sponge. (clinicaltrials.gov)
However, because of his previous experience with the CO 2 laser, Peyman wanted to avoid surface ablation in order to prevent potential corneal scarring and the pain associated with the removal of the corneal epithelium, necessary to expose the surface of the cornea. (wikipedia.org)
Both of them showed development of keratitis during the management with corticosteroids, delayed onset, slow response to antibiotics, and relatively less affected corneal epithelium. (ekjo.org)

While local eye banks and the larger organizations they compete with have the same goal of eliminating corneal blindness, their methods are vastly different and each present unique challenges and opportunities. (dovepress.com)
1 Since this time, the importance of corneal blindness cannot be overstated, as diseases affecting the cornea are currently the third leading cause of blindness worldwide. (dovepress.com)
2 Corneal transplants have been instrumental in their ability to combat corneal pathology as a cause of blindness. (dovepress.com)
Currently, the only way to cure blindness caused by corneal endothelial dysfunction is via corneal transplantation of a cadaver donor cornea with healthy corneal endothelium. (medsci.org)
In this review, we present current advances in reprogramming corneal endothelial cells in vitro , detail the methods to successful engineer human corneal endothelial grafts, and discuss their future clinical applications to cure corneal blindness. (medsci.org)
As a result, bullous keratopathy due to either an insufficient cell density caused by HCEC dysfunction or a retro-corneal membrane elicited by endothelial mesenchymal transition (EMT) may occur resulting in a cloudy cornea and potential corneal blindness [ 12 , 13 ]. (medsci.org)
Corneal blindness is one of the most important causes of blindness in India and this can be treated by corneal transplantation. (indiaeducationdiary.in)

She performs a variety of eye surgeries, including cataract surgery, ocular surface reconstruction, and corneal transplantation. (vumc.org)
He has a vast experience in ophthalmic surgery, with a focus on cataract surgery, corneal transplantation, and laser refractive procedures. (washingtonindependent.com)
Claesson M, Armitage WJ, Stenevi U. Corneal oedema after cataract surgery: predisposing factors and corneal graft outcome. (medscape.com)
Dr Minkovitz specializes in laser vision correction as well as cataract surgery (including laser assisted), and is one of only a few Delaware surgeons specially trained in corneal transplantation. (laservisiondelaware.com)

Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft). (surgicaltechedu.org)

Posttransplantation histology demonstrated formation of a monolayer of corneal endothelium attached to the posterior stromal surface. (alchimiasrl.com)
The intraocular cells involved in this production include nonpigmented ciliary epithelial cells, posterior pigment epithelial cells of the iris, pre-equatorial lens capsule epithelial cells, corneal endothelium, trabecular cells, endothelial cells of blood vessels and its adventitia, muscular cells, and ganglion cells of the retina. (hindawi.com)
Quantitatively reduced and morphologically altered corneal endothelium in PEX eyes may lead to a distinct type of keratopathy which diffusely involves the entire cornea. (hindawi.com)
Reliable and valid assessment of corneal endothelial function is a critical input for diagnosing, prognosticating and monitoring progression of disorders affecting corneal endothelium. (who.int)
Diseases surgical technique developed since the start of the involving the corneal endothelium can be controlled twentieth century for the realization of corneal with endothelial or penetrating keratoplasties, and transplantation (CT). (bvsalud.org)
CT is the most common type those diseases that involve both the endothelium and of tissue transplantation made around the world, the corneal stroma generally require PK when there is substitution of all corneal layers (the (REINHART, 2011). (bvsalud.org)
A partial-thickness cornea transplant procedure that involves selective transplantation of the corneal stroma, preserving the Descemet membrane and endothelium. (cdc.gov)

September 14, 2011 - The US Food and Drug Administration (FDA) has granted orphan drug status to a 0.1% riboflavin ophthalmic solution ( VibeX ) combined with an ultraviolet A (UVA) irradiation system ( KXL , Avedro, Inc) to perform corneal cross-linking in the treatment of keratoconus. (medscape.com)
Corneal collagen cross-linking using UVA light with riboflavin photosensitizer is the first medical therapy available in the United States to control the progression of keratoconus. (medscape.com)
Keratoconus is a degenerative disease of the eye that is characterized by progressive thinning of the cornea and represents the leading cause of corneal transplants in the United States. (medscape.com)
Cite this: Orphan Drug Status for Corneal Cross-Linking in Keratoconus - Medscape - Sep 14, 2011. (medscape.com)
Corneal collagen cross-linking, known as CXL, the first and only treatment to date that is proven to stop Keratoconus, KCN, progression. (health.mil)
In 2011, he mastered a practical course on applying the UV-X-TM device (Switzerland) to treat corneal diseases (keratoconus and others). (eximer.ua)

Experimental models of corneal grafts have proved invaluable in advancing understanding of the processes involved in graft rejection (for review see Larkin 1 ). (bmj.com)
7, 8 Orthotopic murine corneal grafts were made possible by advances in surgical instrumentation and the manufacture of fine suture materials. (bmj.com)
Clinically and experimentally, rejection of corneal grafts is recognised as opacification of the cornea. (bmj.com)
Due to severe shortage of donor corneas worldwide, it has become paramount to develop human corneal endothelial grafts in vitro that can subsequently be transplanted in humans. (medsci.org)
Of 6 corneal grafts that demonstrated initial PRPH of lower than 47.5%, 4 failed within 4 to 6 months. (who.int)
The index PRPH was demonstrated to be useful in monitoring and prognosticating outcome of corneal grafts. (who.int)
Professionally, his clinical focus is on contact lens applications for the complex cornea, KC, post grafts, OSD, myopia control and corneal complications. (optometryqldnt.org.au)

After securing the AM filling the defect, a larger layer of AM with the stromal surface facing down is laid and sutured to the healthy stroma with 10-O nylon in either interrupted or running (either zig-zag or purse string) fashion to make sure the top layer of membrane, which will act as a permanent graft, is in close contact with the corneal surface. (osref.org)
Direct transplantation of cultured human CE cells and immortalized HCEC-12 to bare posterior corneal stroma resulted in formation of anendothelial monolayer and restoration of stromal hydration to physiological thickness, demonstrating the feasibility of cell therapy in treatment of CE decompensation in a human in vitro model. (alchimiasrl.com)
0.1ml of stromal cells in a concentration of 5x10^3 cells/uL diluted in the thrombin component of fibrin glue (TISEEL, Baxter) will be applied to the debrided corneal stroma. (clinicaltrials.gov)
That is, HCECs allow fluid leak with solutes and nutrients into the corneal stroma and then transport water from the stroma to the aqueous portion [ 3 ]. (medsci.org)
A small round opacity without epithelial defect was observed in the stroma of the previous corneal incision wound ( Fig. 1A , arrow), but wound infection was not suspected initially because there was no epithelial defect. (ekjo.org)

At CVP Physicians Dayton, our fellowship-trained corneal specialists Dr. Adam Cloud, Dr. David Denlinger and Dr. Jennifer Shade have extensive experience in performing cornea transplants. (cvpdaytoneyedoctors.com)
For example, in 2012, 184,576 corneal transplants were performed in 116 countries for a large variety of indications. (dovepress.com)
3 To put their growth into perspective, in 2017, the combined SightLife consortium provided over 35,000 corneas for transplant worldwide with ~15,000 being transplanted in the US, roughly 30% of the total number of corneal transplants. (dovepress.com)
Since 1961, EBAA member eye banks have provided tissue for more than 2 million sight restoring, life-changing corneal transplants. (restoresight.org)

Aurion Biotech's first candidate is a cell therapy for the treatment of corneal edema secondary to endothelial dysfunction, developed by world-renowned ophthalmic surgeon and research scientist Professor Shigeru Kinoshita and his colleagues at Kyoto Prefecture University of Medicine (KPUM) in Japan. (biospace.com)
Aurion Biotech intends to use the proceeds of this financing to advance its cell therapy program for corneal edema secondary to endothelial dysfunction, which affects approximately 16 million people in the US, Europe and Japan 1 . (biospace.com)
Corneal edema secondary to endothelial dysfunction is a sight-threatening and debilitating condition affecting millions of people throughout the world. (biospace.com)
Ultimately, corneal endothelial cell loss can cause corneal edema and loss of vision. (biospace.com)
Our first candidate is for the treatment of corneal edema secondary to endothelial dysfunction, and is one of the first clinically validated cell therapies for corneal care. (biospace.com)
Image analysis software to analyze photographic images has been described but the analysis is time-consuming and color photographs have limited visualization of vessels in the presence of corneal edema, deposits or scar, even more so for very small caliber or deeper layer vessels. (researchsquare.com)
The 50-year epidemic of pseudophakic corneal edema. (medscape.com)

Mr. Barry Quill is a Consultant Ophthalmic Surgeon whose clinical areas of expertise include Cataract, Refractive, Glaucoma and Corneal Surgery. (blackrock-clinic.ie)
He was subsequently awarded two fellowships from The Royal Perth Hospital, Australia gaining valuable experience in new novel methods of corneal transplantation and minimally invasive glaucoma surgery. (blackrock-clinic.ie)
Glaucoma, Corneal transplantation and Eye banking. (blackrock-clinic.ie)
Diabetic retinopathy (17%), corneal opacities (14%), cataract (12%) and glaucoma (9%) were also important. (who.int)
These special situations include double-headed pterygium, pterygium complicated with co-existing cataract, corneal opacity, ocular surface squamous neoplasia and glaucoma with operated filtering surgery. (ophthbooks.com)

The side effects of an experimental 'gene-silencing' treatment that is currently being investigated for a variety of diseases could be useful in corneal transplantation, where growth of new blood and lymph vessels is believed to be a major cause of graft failure. (ophthalmologytimes.com)
A PKP procedure may be the best choice for patients who have certain eye diseases as well as those who have experienced rejection of a previous corneal graft. (cvpdaytoneyedoctors.com)
His expertise is the mammalian corneal, understanding how it develops and heals, and the diseases that develop when its stem cell reserves are depleted. (edu.au)
Researchers are getting closer to using gene therapy for corneal diseases. (rpbusa.org)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
Richard Franka] Common among the majority of transplant-associated infectious diseases are initial organ donor misdiagnosis or omission of particular infectious diseases from differential diagnosis, inadequate donor screening, and the inability to rapidly test donors for potential infectious diseases, given the short time between organ removal and transplantation. (cdc.gov)
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. (elsevier.com)

PURPOSE: To estimate the incidence of corneal endothelial transplantation and identify risk factors among patients with non-infectious ocular inflammation. (harvard.edu)
Adamo GG, D'Angelo S, Yu AC, Pellegrini M, Bernabei F, Scorcia V, Giannaccare G. Bilateral Corneal Perforation in a Patient with Chronic Ocular Graft-Versus-Host Disease: A Case Report and Literature Review. (lidsen.com)
Therefore, corneal perforation can occur as the presenting manifestation of ocular GVHD. (lidsen.com)
Treatment of severe ocular-surface disorders with corneal epithelial stem cell transplantation. (nih.gov)
This knowledge will aid in constructing more robust ex-vivo corneal epithelial cell constructs for transplantation to treat ocular surface disease. (cardiff.ac.uk)

The company is currently seeking FDA orphan drug status in the treatment of corneal ectasia following refractive surgery. (medscape.com)
In the past, service members with abnormal corneal scans were disqualified from refractive surgery. (health.mil)

The vessel density (VD) was analyzed in the inferior, nasal and temporal corneal margin in all patients, and in the central area, in eyes with central corneal neovascularization (CoNV). (researchsquare.com)

This report summarizes the results of the investigation of these cases and indicates that using the Abtox Plazlyte system to sterilize opthalmologic surgical equipment led to corneal decompensation. (cdc.gov)
A case was defined as corneal endothelial decompensation within 24 hours after surgery in any patient undergoing intraocular ophthalmic surgery during January 5-14, 1998. (cdc.gov)
To ascertain cases and to determine the background rate of corneal decompensation, medical records of patients undergoing ophthalmic surgery during September 1997-January 1998 were reviewed. (cdc.gov)
All patients had post-operative findings of persistent low visual acuity, cloudy corneas with corneal endothelial decompensation, and iris paralysis with dilated pupils. (cdc.gov)
When this rinsate was infused into human and rabbit corneas, corneal decompensation occurred. (cdc.gov)
To test the feasibility of a cell therapy approach to treat corneal endothelial (CE) disorders using an in vitro model of human corneal decompensation. (alchimiasrl.com)
Even moderate rises in intraocular pressure (IOP) or surgical manipulations in the anterior chamber may trigger corneal oedema and decompensation. (hindawi.com)

Our financing speaks volumes about the potential of our cell therapy to transform the lives of millions of people suffering from corneal endothelial dystrophies," said Greg Kunst, chief executive officer of Aurion Biotech. (biospace.com)

Cornea transplantation surgery. (surgicaltechedu.org)
The first traditional eye bank was founded in 1944 to retrieve and store eyes for cornea transplantation and research. (dovepress.com)

The central corneal thickness in eyes with PEX syndrome measured with three different independent methods is higher than that in the non-PEX group, and despite variable peripheral corneal thickness, this one parameter is still crucial in intraocular pressure measurements. (hindawi.com)

Richard Franka] It's true that donor-derived disease transmission following organ transplantation has been reported for many different pathogens, essentially since the beginning of wider use of organ and tissue transplantation. (cdc.gov)
HIV/AIDS, organ transplantation). (cdc.gov)
B. mandrillaris is an opportunistic free-living ameba that can invade the brain through the blood, probably from a primary infection in the skin (from ulcers or dermatitis), sinuses, or via organ transplantation. (cdc.gov)

Dr Leonard Ang specialises in a wide range of corneal disorders as well as in corneal transplantation. (langeye.sg)

Using this PRPH cut off, 80% of Fuchs' endothelial dystrophy and 93.3% of pseudophakic corneal oedema eyes could be demonstrated to have low endothelial function. (who.int)

In 2016, the Food and Drug Administration approved corneal collagen cross-linking, known as CXL. (health.mil)

This ophthalmic macrolide antibiotic is indicated for bacterial conjunctivitis caused by susceptible strains of microorganisms and for prevention of corneal and conjunctival infections. (medscape.com)

Casalita V, Nora RLD, Edwar L, Susiyanti M, Sitompul R. Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study. (ui.ac.id)

Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
a, b) Clinical evaluation of mouse corneal graft. (bmj.com)
This is a investigative initiated, comparative pilot clinical trial to ascertain the safety of application of ex-vivo cultivated limbal stem cells in human eyes for treating different superficial corneal pathologies. (clinicaltrials.gov)
Pre-clinical work in murine models have already demonstrated efficacy of this technique in curing murine corneal pathologies. (clinicaltrials.gov)
OCTA scans allowed the investigation of several corneal planes and the relation of them with clinical findings. (researchsquare.com)

When used as a permanent graft, the aim of AMT is to fill in the corneal stromal defect. (osref.org)
If the epithelial defect has no/minimal stromal loss , amniotic membrane transplantation (AMT) can be performed by either inserting PROKERA™ or suturing a single layer of amniotic membrane (AM) (AMNIOGRAFT® size 2.5 x 2.0 cm or 2.0 x 1.5 cm) to cover both the cornea and the perilimbal conjunctiva (as if a large bandage contact lens). (osref.org)
Stromal thickness reduced from 1218 ± 153 μm to 458 ± 90 μm (63% ± 6%, P = 0.001) after cell transplantation in group 3 and from 1100 ± 86 μm to 489 ± 94 μm (55% ± 7%, P = 0.00004) in group 4. (alchimiasrl.com)
0.5 million stromal and epithelial cells will be incorporated in 0.05ml of commercially available fibrin glue and pasted over the corneal lesion after epithelial debridement. (clinicaltrials.gov)
2 Since antivirals cannot eliminate or block the establishment of latent HSV infection, it is the relapsing and recurring stromal and endothelial disease that renders the greatest morbidity through corneal scarring and neovascularization. (researchsquare.com)
After the microkeratome cut the corneal cap, it was stabilized with suction in the inverted position on a forming die while the refractive cut was made by a second pass of the instrument on the stromal side of the corneal cap. (aao.org)
The reshaped free cap was sutured onto the patient's corneal stromal bed. (aao.org)
In the late 1980s, Ruiz and Rowsey introduced tissue removal from the stromal bed rather than the free corneal cap, referred to as in situ keratomileusis. (aao.org)
Leaving a narrow hinge of tissue allowed the outer cornea to become a flap that is reflected out of the way during the laser exposure, then returned to its original position and allowed to adhere through natural corneal dehydration to the underlying stromal bed (Figure 1). (aao.org)

Since this time there has been an increasingly large volume of papers investigating the immunology of murine corneal graft rejection. (bmj.com)

Our strategy for corneal surface reconstruction includes amniotic membrane transplantation (AMT). (osref.org)
Note the bandlike whitish-grey lesion across the central corneal surface, most prominent on the exposure surfaces, sparing the superior and inferior cornea, and gaps representing corneal nerves passing through the Bowman membrane. (medscape.com)
A 63-year-old man was referred to us because of necrotizing scleritis refractory to the conventional treatment with corticosteroid and amniotic membrane transplantation for 2 months. (ekjo.org)

Nine months before the development of scleritis, he had received an uneventful phacoemulsification and intraocular lens insertion through a corneal incision. (ekjo.org)

There are several types of corneal transplant surgery, which vary based on the technique used and the amount of the cornea which is removed. (cvpdaytoneyedoctors.com)
Conservative treatment with topical steroids and lubricants, bandage contact lens, and lacrimal punctal occlusion surgery resulted in the successful resolution of the corneal perforation with satisfactory visual recovery in the right eye. (lidsen.com)
Jose I. Barraquer, MD, described corneal lamellar surgery for the correction of refractive error in 1949. (aao.org)
An adhesive that binds wound edges together successfully heals corneal wounds without surgery. (rpbusa.org)
His residency was at Thomas Jefferson and its associated Wills Eye Hospital, and he finished his education with fellowships in cataract and corneal surgery at the University of Connecticut. (washingtonindependent.com)
This book comprises of four sections which include 26 chapters following as etiopathogenesis of pterygium, workup of a case of pterygium, pterygium excision with conjunctival autografting using glue, pterygium excision with conjunctival autograft (suture technique), conjunctival excision and extended tenectomy with conjunctival autograft for primary pterygium, pterygium surgery with autograft affixation using blood, antimetabolites in pterygium management, adjunctive therapy in pterygium management, management of corneal opacity after pterygium surgery etc. (ophthbooks.com)

Professor Nick Di Girolamo is a research-focused academic leading an internationally recognised group whose mission is to restore sight in patients blinded from severe corneal disease. (edu.au)
Severe cases were treated with corneal transplantation. (health.mil)

Corneal graft rejection presents clinically and in experimental models as opacification and is considered to be the result of endothelial cell dysfunction or loss. (bmj.com)
In fact, corneal opacification arise from the complex interplay between viral activity and the host immune response and the subsequent inappropriate blood vessel formation in the normally transparent and avascular cornea. (researchsquare.com)

In this prospective interventional study patients with superficial corneal pathologies like scars, ulcers and burns will undergo a surgical procedure. (clinicaltrials.gov)

Corneal transplantation with a healthy donor cornea has been the only available treatment for corneal endothelial disease. (mdpi.com)
From a single donor, the Company can manufacture corneal endothelial cells to treat up to 100 recipient eyes. (biospace.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)

Healthy corneal tissues from deceased donors are typically widely available. (cvpdaytoneyedoctors.com)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
At the Illinois Eye and Ear Infirmary , Peyman, because of his interest in the effects of lasers on tissues in the eye, began evaluating the potential use of a CO 2 laser to modify corneal refraction in rabbits. (wikipedia.org)
The biomicroscopic examination is one of the techniques used to evaluate the quality of corneal tissues. (bvsalud.org)

Identification of a protein (called thymosin beta 4) that regulates corneal responses to injury and inflammation could lead to new drug therapies. (rpbusa.org)
IFN-λ Regulates Neutrophil Biology to Suppress Inflammation in Herpes Simplex Virus-1-Induced Corneal Immunopathology. (peprotech.com)

All eyes underwent anterior segment Slit-Lamp photography (SLP), and Optical Coherence Tomography Angiography (OCT) with en-face, b-scans and c-scans imaging. (researchsquare.com)
Currently assessment of the corneal and anterior segment (AS) vasculature is constrained to slit lamp photography (SLP) or angiography techniques. (researchsquare.com)

Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. (lidsen.com)
We reported the case of a 65-year-old male patient who developed corneal perforation sequentially in both eyes 3 years after receiving HSCT. (lidsen.com)

Post-operative recovery for cell therapy is several hours, as compared to several days for corneal transplant procedures. (biospace.com)

Since investigation of the mechanism and treatment of allograft rejection is the central purpose of much of the current research, it is relevant to define precisely what is meant by corneal graft rejection. (bmj.com)
OCTA can be useful in both qualitative and quantitative follow-up of patients and may become a non-invasive alternative to objectively monitor treatment response in eyes with corneal vascularization due to herpetic infection. (researchsquare.com)

Anatomy3

Organisms3

Diseases8

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes6

Named Groups2

Health Care2

Causes of corneal graft failure in India. (1/579)

Streptococcal keratitis after myopic laser in situ keratomileusis. (2/579)

Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases. (3/579)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (4/579)

Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. (5/579)

Spherical and aspherical photorefractive keratectomy and laser in-situ keratomileusis for moderate to high myopia: two prospective, randomized clinical trials. Summit technology PRK-LASIK study group. (6/579)

Clinical estimation of corneal endothelial pump function. (7/579)

A new surgical technique for deep stromal, anterior lamellar keratoplasty. (8/579)

Corneal Transplantation

Keratoplasty, Penetrating

Fuchs' Endothelial Dystrophy

Corneal Diseases

Cornea

Corneal Neovascularization

Endothelium, Corneal

Eye Banks

Corneal Edema

Graft Survival

Keratoconus

Transplantation, Homologous

Graft Rejection

Corneal Stroma

Pseudophakia

Liver Transplantation

Descemet Stripping Endothelial Keratoplasty

Transplantation, Isogeneic

Tissue Donors

Kidney Transplantation

Collagen Type VIII

Bone Marrow Transplantation

Ophthalmic Solutions

Hematopoietic Stem Cell Transplantation

Lymphangiogenesis

Heart Transplantation

Transplantation, Autologous

Keratitis

Lung Transplantation

Visual Acuity

Mice, Inbred BALB C

Stem Cell Transplantation

Transplantation Conditioning

Mice, Inbred C57BL

Organ Transplantation

Pancreas Transplantation

Cell Count

Islets of Langerhans Transplantation

Transplantation

Transplantation Immunology

Cell Transplantation

Transplantation Chimera

Immunosuppressive Agents

Graft vs Host Disease

Living Donors

Transplantation, Heterotopic

Treatment Outcome

Cord Blood Stem Cell Transplantation

Heart-Lung Transplantation

Causes of corneal graft failure in India. (1/579)

Streptococcal keratitis after myopic laser in situ keratomileusis. (2/579)

Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases. (3/579)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (4/579)

Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. (5/579)

Spherical and aspherical photorefractive keratectomy and laser in-situ keratomileusis for moderate to high myopia: two prospective, randomized clinical trials. Summit technology PRK-LASIK study group. (6/579)

Clinical estimation of corneal endothelial pump function. (7/579)

A new surgical technique for deep stromal, anterior lamellar keratoplasty. (8/579)

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$Cornea, External Diseases, & Refractive Surgery | Dean McGee Eye Institute$ Cornea, External Diseases, & Refractive Surgery | Dean McGee Eye Institute

$Official ESCRS | European Society of Cataract & Refractive Surgeons$ Official ESCRS | European Society of Cataract & Refractive Surgeons

$Official ESCRS | European Society of Cataract & Refractive Surgeons$ Official ESCRS | European Society of Cataract & Refractive Surgeons