Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.Keratoplasty, Penetrating: Partial or total replacement of all layers of a central portion of the cornea.Fuchs' Endothelial Dystrophy: Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.Corneal Diseases: Diseases of the cornea.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Corneal Neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.Endothelium, Corneal: Single layer of large flattened cells covering the surface of the cornea.Eye Banks: Centers for storing various parts of the eye for future use.Corneal Edema: An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Keratoconus: A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Corneal Stroma: The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.Pseudophakia: Presence of an intraocular lens after cataract extraction.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Descemet Stripping Endothelial Keratoplasty: A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Kidney Transplantation: The transference of a kidney from one human or animal to another.Collagen Type VIII: A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Ophthalmic Solutions: Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Lymphangiogenesis: The formation of LYMPHATIC VESSELS.Heart Transplantation: The transference of a heart from one human or animal to another.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Keratitis: Inflammation of the cornea.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Visual Acuity: Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.Mice, Inbred BALB CStem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Mice, Inbred C57BLOrgan Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Lasers, Excimer: Gas lasers with excited dimers (i.e., excimers) as the active medium. The most commonly used are rare gas monohalides (e.g., argon fluoride, xenon chloride). Their principal emission wavelengths are in the ultraviolet range and depend on the monohalide used (e.g., 193 nm for ArF, 308 nm for Xe Cl). These lasers are operated in pulsed and Q-switched modes and used in photoablative decomposition involving actual removal of tissue. (UMDNS, 2005)Keratomileusis, Laser In Situ: A surgical procedure to correct MYOPIA by CORNEAL STROMA subtraction. It involves the use of a microkeratome to make a lamellar dissection of the CORNEA creating a flap with intact CORNEAL EPITHELIUM. After the flap is lifted, the underlying midstroma is reshaped with an EXCIMER LASER and the flap is returned to its original position.

Causes of corneal graft failure in India. (1/579)

The success of corneal grafting in visual rehabilitation of the corneal blind in India depends on survival of the grafts. Understanding the causes of graft failure may help reduce the risk of failure. We studied these causes in a series of 638 graft failures at our institution. Multivariate logistic regression analysis was used to evaluate the association of particular causes of graft failure with indications for grafting, socioeconomic status, age, sex, host corneal vascularization, donor corneal quality, and experience of surgeon. The major causes of graft failure were allograft rejection (29.2%), increased intraocular pressure (16.9%), infection excluding endophthalmitis (15.4%), and surface problems (12.7%). The odds of infection causing graft failure were significantly higher in patients of lower socioeconomic status (odds ratio 2.45, 95% CI 1.45-4.15). Surface problems as a cause of graft failure was significantly associated with grafts done for corneal scarring or for regrafts (odds ratio 3.36, 95% CI 1.80-6.30). Increased intraocular pressure as a cause of graft failure had significant association with grafts done for aphakic or pseudophakic bullous keratopathy, congenital conditions or glaucoma, or regrafts (odds ratio 2.19, 95% CI 1.25-3.84). Corneal dystrophy was the indication for grafting in 12 of the 13 cases of graft failure due to recurrence of host disease. Surface problems, increased intraocular pressure, and infection are modifiable risk factors that are more likely to cause graft failure in certain categories of patients in India. Knowledge about these associations can be helpful in looking for and aggressively treating these modifiable risk factors in the at-risk categories of corneal graft patients. This can possibly reduce the chance of graft failure.  (+info)

Streptococcal keratitis after myopic laser in situ keratomileusis. (2/579)

A 24-year-old healthy male underwent uncomplicated laser in situ keratomileusis (LASIK) in left eye. One day after the surgery, he complained of ocular pain and multiple corneal stromal infiltrates had developed in left eye. Immediately, the corneal interface and stromal bed were cleared, and maximal antibiotic treatments with fortified tobramycin (1.2%) and cefazolin (5%) were given topically. The causative organism was identified as 'Streptococcus viridans' both on smear and culture. Two days after antibiotic therapy was initiated, the ocular inflammation and corneal infiltrates had regressed and ocular pain was relieved. One month later, the patient's best corrected visual acuity had returned to 20/20 with -0.75 -1.00 x 10 degrees, however minimal stromal scarring still remained. This case demonstrates that microbial keratitis after LASIK, if treated promptly, does not lead to a permanent reduction in visual acuity.  (+info)

Peribulbar anaesthesia during keratoplasty: a prospective study of 100 cases. (3/579)

AIMS: A prospective study was carried out in order to evaluate the efficacy and safety of peribulbar anaesthesia during keratoplasty and to describe surgical conditions. METHODS: Of 137 consecutive keratoplasties, 100 (73%) were performed under peribulbar anaesthesia. Patients received a mean volume of 16.5 (SD 4) ml (range 9-22 ml) of a mixture of etidocaine, bupivacaine, and hyaluronidase. Ocular compression duration was at least 20 minutes and intraocular pressure (IOP) was measured with a Tonopen after injection, compression, and before trephination. Degree of akinesia, pain scoring, complications, and surgical conditions were studied. RESULTS: Before trephination, IOP was 5.73 mm Hg below the preinjection value and was never above 21 mm Hg. Akinesia was complete in 80% of cases and 94% of patients found that surgery was painless. Two patients (2%) were very agitated during surgery. The last patient presented with an acute intraoperative suprachoroidal haemorrhage that did not result in a true expulsive haemorrhage despite an "open sky" situation. Surgical conditions were judged to be optimal by the patients in 92% of cases and by the surgeon in 98% of cases. CONCLUSION: These results demonstrate that peribulbar anaesthesia offers excellent anaesthesia and akinesia during keratoplasty and may be recommended for this type of surgery.  (+info)

Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. (4/579)

CD4+ T cells of the Th1 type play a central role in acute rejection of solid tissue grafts, including orthotopic corneal allografts. Th1 cells, which mediate delayed hypersensitivity, are the polar opposites of CD4+ Th2 cells, and the latter cells cross-regulate Th1 cells through the unique pattern of cytokines they secrete. As such, Th2 cells may have a useful role to play in preventing rejection of corneal allografts. To test this possibility, the immune systems of adult mice were biased toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA. When immunized subsequently with either OVA or allogeneic corneal tissue, these mice acquired Ag-specific primed T cells of the Th2 type. More important, allogeneic corneas grafted into neovascularized eyes of Th2-biased mice experienced significantly enhanced survival. To demonstrate that enhanced survival was promoted by donor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allografts suppressed orthotopic corneal allograft rejection when adoptively transferred into naive, syngeneic recipients. We conclude that acceptance of corneal allografts in neovascularized mouse eyes can be significantly enhanced by biasing the recipient immune system toward Th2 responses.  (+info)

Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. (5/579)

BACKGROUND: Conditions that destroy the limbal area of the peripheral cornea, such as the Stevens-Johnson syndrome, ocular pemphigoid, and chemical and thermal injuries, can deplete stem cells of the corneal epithelium. The result is scarring and opacification of the normally clear cornea. Standard corneal transplantation cannot treat this form of functional blindness. METHODS: We performed and evaluated 70 transplantations of corneal epithelial stem cells from cadaveric eyes into 43 eyes of 39 patients with severe ocular-surface disorders and limbal dysfunction. Medical treatment had failed in all patients. The patients had a mean preoperative visual acuity of 0.004 (only being able to count the number of fingers presented by the examiner) in the affected eyes, which satisfies the criteria for legal blindness in most countries. In 28 eyes, we also performed standard corneal transplantation. Stem-cell transplantations were performed as many as four times on 1 eye if the initial results were not satisfactory; 19 eyes had multiple transplantations. Patients were followed for at least one year after transplantation. RESULTS: A mean of 1163 days after stem-cell transplantation, 22 of the 43 eyes (51 percent) had corneal epithelialization; of the 22 eyes, 7 eyes had corneal stromal edema and 15 eyes had clear corneas. Mean visual acuity improved from 0.004 to 0.02 (vision sufficient to distinguish the largest symbol on the visual-acuity chart from a distance of 1 m) (P<0.001). The 15 eyes in which the cornea remained clear had a final mean visual acuity of 0.11 (the ability to distinguish the largest symbol from a distance of 5 m). Complications of the first transplantation included persistent defects in the corneal epithelium in 26 eyes, ocular hypertension in 16 eyes, and rejection of the corneal graft in 13 of 28 eyes. The epithelial defects eventually healed in all but two of the eyes. CONCLUSIONS: Transplantation of corneal epithelial stem cells can restore useful vision in some patients with severe ocular-surface disorders.  (+info)

Spherical and aspherical photorefractive keratectomy and laser in-situ keratomileusis for moderate to high myopia: two prospective, randomized clinical trials. Summit technology PRK-LASIK study group. (6/579)

OBJECTIVE: Determine the outcomes of single-zone photorefractive keratectomy (SZPRK), aspherical photorefractive keratectomy (ASPRK), and laser in-situ keratomileusis (LASIK) for the correction of myopia between -6 and -12 diopters. DESIGN: Two simultaneous prospective, randomized, multi-center clinical trials. PARTICIPANTS: 286 first-treated eyes of 286 patients enrolled in one of two studies. In Study I, 134 eyes were randomized to SZPRK (58 eyes) or ASPRK (76 eyes). In Study II, 152 eyes were randomized to ASPRK (76 eyes) or to LASIK (76 eyes). INTERVENTION: All eyes received spherical one-pass excimer laser ablation as part of PRK or LASIK performed with the Summit Technologies Apex laser under an investigational device exemption, with attempted corrections between -6 and -12 diopters. MAIN OUTCOME MEASURES: Data on uncorrected and best spectacle-corrected visual acuity, predictability and stability of refraction, and complications were analyzed. Follow-up was 12 months. RESULTS: At 1 month postoperatively, more eyes in the LASIK group achieved 20/20 and 20/25 or better uncorrected visual acuity than PRK-treated eyes; at the 20/25 or better level, the difference was significant for LASIK (29/76 eyes, 38%) over SZPRK (10/58 eyes, 17%) (P = .0064). At all subsequent postoperative intervals, no difference was seen between treatment groups. Similarly, best corrected visual acuities were better for LASIK than all PRK eyes at 1 month postoperatively, and LASIK was better than SZPRK at 3 months follow-up (e.g., for 20/20 or better at 1 month, LASIK 50/76 eyes (66%) versus SZPRK 24/57 eyes (42%), P = .0066). PRK eyes had a mean loss of BCVA through 6 months, while LASIK eyes had a slight gain of mean BCVA through month 6; at 12 months, both ASPRK groups but not SZPRK continued to have a small mean loss of BCVA (e.g., compared to preoperative, mean BCVA at 12 months for SZPRK was + 0.3, LASIK was +.21, ASPRK I was -0.11, and ASPRK II -0.31 (SZPRK versus ASPRK II, P = .0116). Predictability was better for PRK than LASIK at all follow-up intervals (e.g., for manifest refraction spherical equivalent +/- 1.0 diopters at 6 months, ASPRK I 42/62 eyes (68%) versus LASIK 29/72 eyes (40%), P = .0014%). Stability was slightly but insignificantly less in the LASIK eyes compared to PRK eyes. All visual outcome measures were better for eyes with preoperative myopia between -6 and -8.9 D compared with eyes with myopia between -9 and -12 D. No consistent differences in refractive outcomes or postoperative corneal haze were seen between aspherical and single-zone ablations; haze diminished over 12 months and was judged to be vision-impairing in only one ASPRK eye. Microkeratome and flap complications occurred in 4 eyes, resulting in delay of completion of the procedure in 3 eyes but not causing long-term impairment. CONCLUSIONS: Improvement in uncorrected visual acuity and return of best corrected visual acuity was more rapid for LASIK than PRK, but efficacy outcomes in the longer term through 12 months were similar for all treatment groups. LASIK eyes tended toward undercorrection with the nomogram employed in this study compared to PRK, but the scatter was similar, suggesting little difference between these procedures for most patients by 6 months and thereafter. No consistent advantage was demonstrated between aspherical and single-zone ablation patterns. Predictability was much better for all procedures for corrections of -6 to -8.9 D compared with -9 to -12 D. Sporadic loss of best corrected vision in the PRK eyes not found in the LASIK eyes and other measures of visual function require further study.  (+info)

Clinical estimation of corneal endothelial pump function. (7/579)

PURPOSE: To develop a technique to estimate the corneal endothelial pump rate in human subjects. METHODS: Corneal hydration control is thought to be maintained by a pump-leak mechanism whereby the leak of solutes and fluid across the endothelial barrier into the stroma is, in the steady state, exactly balanced by the pumping of solutes and passive fluid transfer across the endothelium to the aqueous humor. Overall corneal hydration control can be measured from the rate at which the swollen cornea thins (deswells), and a measure of the leak can be obtained simultaneously from the endothelial permeability to fluorescein. From the pump-leak hypothesis, the deswelling rate is directly proportional to the pump rate and inversely proportional to the leak rate. The relative endothelial pump rate can be estimated as the product of the normalized deswelling rate and the normalized endothelial permeability. This procedure was used to obtain the relative endothelial pump rate in 41 patients with diabetes mellitus, 12 patients with long-term corneal transplants, 20 long-term wearers of contact lenses, and 19 normal volunteer subjects after the short-term administration of topical dorzolamide. RESULTS: The relative endothelial pump rate did not differ significantly from that of control subjects in diabetics, in contact lens wearers, and after dorzolamide administration, but was markedly decreased in the patients with corneal transplants, despite a reduction in permeability (reduced leak). CONCLUSIONS: This method allows the estimation of both the barrier and pump arms of corneal endothelial function and should be useful in the investigation of causes and mechanisms of functional endothelial insufficiency.  (+info)

A new surgical technique for deep stromal, anterior lamellar keratoplasty. (8/579)

AIMS: To describe a new surgical technique for deep stromal anterior lamellar keratoplasty. METHODS: In eye bank eyes and sighted human eyes, aqueous was exchanged by air, to visualise the posterior corneal surface--that is, the "air to endothelium" interface. Through a 5.0 mm scleral incision, a deep stromal pocket was created across the cornea, using the air to endothelium interface as a reference plane for dissection depth. The pocket was filled with viscoelastic, and an anterior corneal lamella was excised. A full thickness donor button was sutured into the recipient bed after stripping its Descemet's membrane. RESULTS: In 25 consecutive human eye bank eyes, a 12% microperforation rate was found. Corneal dissection depth averaged 95.4% (SD 2.7%). Six patient eyes had uneventful surgeries; in a seventh eye, perforation of the lamellar bed occurred. All transplants cleared. Central pachymetry ranged from 0.62 to 0.73 mm. CONCLUSION: With this technique a deep stromal anterior lamellar keratoplasty can be performed with the donor to recipient interface just anterior to the posterior corneal surface. The technique has the advantage that the dissection can be completed in the event of inadvertent microperforation, or that the procedure can be aborted to perform a planned penetrating keratoplasty.  (+info)

*Corneal transplantation

... , also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal collagen cross-linking may delay or eliminate the need for corneal transplantation in keratoconus and post-LASIK ... Different types of contact lenses may be used to delay or eliminate the need for corneal transplantation in corneal disorders. ... However, in most of the cases where corneal transplantation is recommended, PTK would not be effective. In corneal disorders ...

*Immune privilege

CS1 maint: Multiple names: authors list (link) Niederkorn, Jerry Y. (2017-01-27). "Corneal Transplantation and Immune Privilege ... Niederkorn, Jerry Y. (2013-01-13). "Corneal Transplantation and Immune Privilege". International Reviews of Immunology. 32 (1 ... Taylor, Andrew W. (2016-01-01). "Ocular Immune Privilege and Transplantation". Alloimmunity and Transplantation. 7: 37. doi: ... Compared to skin allografts, which are rejected in almost 100% of cases, corneal allografts survive long-term in 50-90% of ...

*Eduard Zirm

Human corneal transplantation (keratoplasty) had been attempted with little or no success throughout the 1800s using both ... Zirm - Die erste geglückte Organtransplantation - 1905 Centennial review of corneal transplantation. (Clin Experiment ... "Centennial review of corneal transplantation". Clin Experiment Ophthalmol. 33 (6): 642-57. doi:10.1111/j.1442-9071.2005.01134.x ... Zirm 's method remains the basis for repairing corneal damage. Zirm played the violin and in his limited spare time studied ...

*Legacy Devers Eye Institute

They have also improved corneal transplantation through innovations in DLEK (deep lamellar endothelial keratoplasty) and DSEK ( ... Samanlego, Chiles Aedam R. (29 April 2014). "New therapeutic dimensions in corneal transplantation". Eyeworld Daily News. p. 20 ... innovative corneal transplant surgeon Peter Veldman, corneal transplant surgeon and instructor at Harvard Medical School " ...

*Topical anesthetic

... such patients finally require corneal transplantation. In case of prolonged or chronic eye pain, especially neuropathic eye ... Chern KC, Meisler DM, Wilhelmus KR, Jones DB, Stern GA, Lowder CY (January 1996). "Corneal anesthetic abuse and Candida ... topical anesthetics can cause severe and irreversible damage to corneal tissues and even loss of the eye. The abuse of topical ... often ending up with irreversible corneal damage or even destruction (which is a vicious cycle and causes even much more pain ...

*Lattice corneal dystrophy

In this case, a corneal transplantation may be needed. There have been many cases in which teenage patients have had the ... Although people with lattice dystrophy have an excellent chance for a successful corneal transplantation, the disease may also ... Lattice corneal dystrophy type, also known as Biber-Haab-Dimmer dystrophy, is a rare form of corneal dystrophy. It has no ... In case of corneal erosion, a doctor may prescribe eye drops and ointments to reduce the friction on the eroded cornea. In some ...

*S Nijalingappa Medical College, HSK (Hanagal Shree Kumareshwar) Hospital and Research Centre

Kidney transplantation and Corneal transplantation are conducted in the Hospital.. ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ...

*JSS Medical College

Kidney transplantation and Corneal transplantation are conducted in the Hospital. JSS Hospital is the first Hospital to conduct ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ... Renal Transplantation outside Bangalore in the state of Karnataka. http://alumni.jssmedicalcollege.in/ http://www.jsshospital. ...

*Eye surgery

"Corneal Transplantation - procedure, recovery, blood, removal, complications, adults, time, infection". www.surgeryencyclopedia ... Epikeratophakia is the removal of the corneal epithelium and replacement with a lathe cut corneal button. Intracorneal rings ( ... Lasers may be used to treat nonrefractive conditions (e.g. to seal a retinal tear). Laser eye surgery or laser corneal surgery ... It is used for preventing or treating vitreous loss during cataract or corneal surgery, or to remove misplaced vitreous in ...

*Shri B. M. Patil Medical College

Kidney transplantation and Corneal transplantation are conducted in the Hospital. Official Website of B.M.Patil Medical College ... The main purpose of this association is to receive the donor's bodies for corneal transplantation to the blind, research ...

*Karl Gustav Himly

1] Academician V.P. Filatov and the problems of corneal transplantation. ... In addition, he performed early investigations involving the possibilities of corneal grafting. In 1802, with Johann Adam ...

*Macular corneal dystrophy

Corneal transplantation is often required. Corneal dystrophy Groenouw A. Knötchenförmige Hornhauttrübungen (noduli corneae). ... Macular corneal dystrophy is very common in Iceland and accounts for almost one-third of all corneal grafts performed there. ... Macular corneal dystrophy, also known as Fehr corneal dystrophy named for German ophthalmologist Oskar Fehr (1871-1959), is a ... "Macular corneal dystrophy". eMedicine. Online Mendelian Inheritance in Man (OMIM) 217800 Klintworth GK (2009). "Corneal ...

*Mucolipidosis type IV

The corneal clouding can be, at least, temporarily corrected by corneal transplantation. See the equivalent section in the main ... Most patients with ML IV show psychomotor retardation (i.e., delayed development of movement and coordination), corneal opacity ...

*Gelatinous drop-like corneal dystrophy

Recurrence within a few years occurs in all patients following corneal transplantation. Soft contact lenses are effective in ... Gelatinous drop-like corneal dystrophy, also known as amyloid corneal dystrophy, is a rare form of corneal dystrophy. The ... This form of corneal amyloidosis appears to be more frequent in Japan. A number of mutations causing this disease have been ... Nakaizumi, K. : A rare case of corneal dystrophy. Acta. Soc. Ophthal. Jpn. 18: 949-950, 1914 Online Mendelian Inheritance in ...

*Keryn Williams

Her research interests include corneal transplantation, ocular inflammation, ocular immunology and eye banking. Williams ... service to medical science in the field of ophthalmology through the research and development of corneal transplantation, as an ... Australian Corneal Graft Registry 1997 Principal Research Fellow, Department of Ophthalmology, Flinders University of South ...

*Gerard Sutton

His specialty is laser vision correction, cataract and lens surgery, and corneal transplantation. Sutton graduated in medicine ... Sutton became the inaugural Professor of Corneal and Refractive Surgery at the Sydney Eye Hospital and the University of Sydney ... from glasses to corneal grafts and everything in between. Wilkinson Publishing Melbourne, Victoria, Australia. ...

*Janis Babson

When Janis died of leukemia in 1961, corneal transplantation was a relatively unknown procedure. Although parents who lose ... The program's hosts explained how some cases of blindness could be cured with corneal donations, restoring a recipient's ...

*Network of Excellence for Functional Biomaterials

Every year approximately 10,000,000 people are affected by various eye disorders and require corneal transplantation. Tissue ... Corneal diseases are the major cause of vision loss worldwide. ...

*Vladimir Filatov

First corneal transplantation was attempted by Filatov on 28 February 1912, but the graft grew opaque. After numerous attempts ... He introduced the tube flap grafting method, corneal transplantation and preservation of grafts from cadaver eyes. He founded ... Ramon Castroviejo - a Spanish contemporary of Filatov that was also a pioneer in corneal transplantation. David Bushmich - an ... over the course of many years, Filatov achieved a successful transplantation of cornea from a diseased person on 6 May 1931. ...

*Ramon Castroviejo

... prompting the worldwide adoption of corneal transplantation as a standard way to deal with severe corneal pathology. His ... Vladimir Filatov - a Soviet contemporary of Castroviejo that was also a pioneer in corneal transplantation. Atlas of ... was a famous Spanish and American eye surgeon remembered for his achievements in corneal transplantation. Born in Logroño, ...

*Corneal hydrops

Corneal transplantation is not usually indicated during corneal hydrops. The person experiences pain and a sudden severe ... Corneal hydrops or corneal rupture is an uncommon complication seen in people with advanced keratoconus or other corneal ... Corneal hydrops might be caused by a tear in the recently discovered Dua's layer, a 15 micron thick layer between the corneal ... and understanding of corneal dystrophies and pathologies, such as acute hydrops. "Acute Corneal Hydrops". University of ...

*Berthold Seitz

He was heading the Cornea Bank Erlangen since 2000 and went main surgeon for corneal transplantation. In 1997, he became an ... Amniotic membrane transplantation Cofounder and speaker of the Corneal Section in the DOG since 2002 Seitz received many ... He is known for his scientific contributions in the fields of cornea transplantation (especially methods for minimisation of ... and artificial lens-calculation after refractive corneal surgery as well as techniques of amniotic membrane transplantation and ...

*Keratoconus

Corneal transplantation is not usually indicated during corneal hydrops. The National Eye Institute reports keratoconus is the ... The first successful corneal transplantation to treat keratoconus was done in 1936 by Ramon Castroviejo. According to the ... In a small number of people scarring of the cornea occurs and a corneal transplantation is required. Keratoconus affects about ... The corneal transplant surgeon trephines a lenticule of corneal tissue and then grafts the donor cornea to the existing eye ...

*Retrobulbar block

... can be used successfully for corneal transplantation but may require a supplemental facial nerve block. ...

*Gerd Geerling

His surgical specialty lies in the anterior segment of the eye, with a particular focus on corneal transplantation. In addition ... From 2000 on, Geerling worked as corneal consultant in Lübeck introducing corneal lamellar surgery. In 2003 he completed his ... Corneal diasease and keratectasias. He was one of the first to introduce modern lamellar corneal graft techniques in Germany ... Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. Coauthors: Peter ...

*Human T-lymphotropic virus 1

One case report describes an HTLV-1 infected woman who developed chronic refractory eczema, corneal injury and adult T cell ... She was subsequently treated with allogenic stem cell transplantation and had complete resolution of symptoms. One year post- ... Allogenic bone marrow transplantation has been investigated in the treatment of HTLV-1 disease with varied results. ...
Purpose: : T lymphocytes have a central role in rejection of corneal grafts. The primary interaction leading to activation of T cells is the engagement of the MHC molecule on the APC with the T cell surface receptor. However, an additional costimulatory signal from APC to T cell is necessary for full T cell activation. It was investigated whether modulation of the recently described costimulatory pathways Programmed Death 1 (PD-1) and the Inducible costimulatory molecule (ICOS) play a role in corneal allograft rejection. Methods: : A dimeric PDL1 immunoglobulin (Ig) fusion protein was generated to stimulate the inhibitory receptor PD-1 and suppress a T cell response. A monoclonal antibody was used to block the costimulatory molecule ICOS resulting in T cell suppression. PDL1.Ig and anti ICOS antibody were then used in a mouse model of corneal transplantation. Results: : Both reagents demonstrated T cell inhibition in vitro. Plate bound PDL1.Ig inhibited T cells proliferation in a dose dependent ...
Purpose: To describe outcomes of corneal transplantation for irreversible corneal decompensation from corneal endotheliitis in Asian eyes. Design: Retrospective, observational case series. Methods: We reviewed consecutive patients with corneal endotheliitis (32 eyes of 31 subjects) who underwent keratoplasty (January 1, 2008-December 1, 2009). All eyes had preoperative aqueous polymerase chain reaction (PCR) analysis for viruses, including cytomegalovirus (CMV). CMV-positive patients were treated preoperatively with topical corticosteroids and anti-CMV treatment (oral valganciclovir 900 mg twice daily, topical ganciclovir 0.15% 5 applications per day, for 6 weeks) with complete resolution of ocular inflammation, and quiescence for at least 6 months before corneal transplantation. Our main outcome measure was recurrence of endotheliitis within 1 year after corneal transplantation. Results: Five eyes were CMV positive; the remaining 27 eyes were negative for all viruses on PCR analysis. ...
Get information, facts, and pictures about Corneal transplantation at Encyclopedia.com. Make research projects and school reports about Corneal transplantation easy with credible articles from our FREE, online encyclopedia and dictionary.
The purpose is to report a case of Candida interface infection after deep anterior lamellar keratoplasty (DALK). A 23-year-old female patient underwent DALK surgery in the left eye for keratoconus. Four weeks after the surgery, she presented with asymptomatic white-cream colored deposits at the graft-host interface. Epithelial ingrowth was our first possible diagnosis because there were no symptoms or signs of inflammation. However, progression of the lesion under steroid treatment and the appearance of inflammation signs after tapering the steroid treatment raised suspicion of fungal keratitis. Anterior segment optical coherence tomography (OCT), ultrasound biomicroscopy, confocal microscopy and microbiologic examinations of the cornea were performed to evaluate the lesion. Anterior segment OCT and ultrasound biomicroscopy confirmed the lesion to be at the interface. The confocal scan disclosed hyper-reflective deposits and surrounding inflammatory cells but there were no hyphae-like ...
Objective: Deep anterior lamellar keratoplasty (DALK) significantly reduces the post-transplantation morbidity in patients eligible for partial-thickness c
From BioPortfolio: Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study Eye advance online publicati...
Purpose: : Previous studies have demonstrated that allergic conjunctivitis increases the incidence and tempo of corneal allograft rejection in mice. We wished to determine if Th2-based allergic inflammation in the lungs or Th1-based inflammation of the skin would exacerbate corneal graft rejection. Methods: : Airway hyperreactivity (AHR) was induced in BALB/c mice using either ovalbumin (OVA) or short ragweed extract (SRW). AHR was confirmed by plethysmography and by ELISA and histological analysis of bronchoalveolar lavage fluid (BALF). Contact hypersensitivity was induced by skin painting with oxazalone prior to corneal transplantation. Delayed-type hypersensitivity (DTH) responses to donor alloantigens and to skin sensitization were determined using conventional ear-swelling assays. C57BL/6 corneal allografts were transplanted orthotopically to naïve mice, mice sensitized and challenged with oxazalone, or mice with ongoing AHR. Results: : Mice with ongoing AHR that was induced with SRW ...
In corneal transplantation a diseased or scarred cornea is replaced with a healthy one. Special microsurgical instruments are used to remove the diseased part of the cornea and replace it with a transparent donor cornea. Fine nylon sutures secure the donor cornea in place, and antibiotics are administered locally to prevent infection. The eye is dressed with sterile gauze pads and a protective shield. Following surgery, the eye needs to be protected and eye drops applied for several months to promote healing. Some patients get good vision in two to three months, while others must wait for complete healing, which occurs at about a year.. Corneal transplantation enjoys a high success rate. The most important factors determining success are the underlying disease process and the quality of the tissue used during transplantation. Should the body reject a new cornea, it can be successfully treated if medication is administered at the first sign of symptoms. For this reason, it is important that ...
Full thickness corneal transplant. Your entire cornea may need to be replaced if both the front and inner corneal layers are damaged. This is called penetrating keratoplasty (PK), or full thickness corneal transplant. Your diseased or damaged cornea is removed. Then the clear donor cornea is sewn into place.. PK has a longer recovery period than other types of corneal transplants. Getting complete vision back after PK may take up to 1 year or longer.. With a PK, there is a slightly higher risk than with other types of corneal transplants that the cornea will be rejected. This is when the bodys immune system attacks the new cornea tissue.. Partial thickness corneal transplant. Sometimes the front and middle layers of the cornea are damaged. In this case, only those layers are removed. The endothelial layer, or the thin back layer, is kept in place. This transplant is called deep anterior lamellar keratoplasty (DALK) or partial thickness corneal transplant. DALK is commonly used to treat ...
The effect of donor age on corneal graft survival was evaluated. Two groups of patients were followed up 18 months after keratoplasty. In both groups one half of the patients (53.1%) were with high-risk keratoplasties. For transplantations were used moist chamber preserved grafts. Donor-recipient histocompatibility matching was not done. Blood group antigens (ABO), donor and recipient sex were distributed randomly. During the follow-up period all patients were examined by slit lamp biomicroscopy. Group A: donor age | or = 60, after the 18 month follow-up period 82.7% of grafts were found clear. Group B: donor age | or = 60, after the 18-month follow-up period 80% of grafts were found clear. chi 2 = 0.08. There was no statistically significant difference between group A and group B.
In corneal transplant, also known as keratoplasty, a patients damaged corneais replaced by the cornea from the eye of a human cadaver. This is the single most common type of human transplant surgery and has the highest success rate. Eye banks acquire and store eyes from donor individuals largely to supplythe need for transplant corneas.. Corneal transplant is used when vision is lost in an eye because the cornea has been damaged by disease or traumatic injury. Some of the disease conditions that might require corneal transplant include the bulging outward of the cornea (keratoconus), a malfunction of the inner layer of the cornea (Fuchs dystrophy), and painful swelling of the cornea (pseudophakic bullous keratopathy). Some of these conditions cause cloudiness of the cornea; others alter itsnatural curvature, which can also reduce the quality of vision.. Injury to the cornea can occur because of chemical burns, mechanical trauma,or infection by viruses, bacteria, fungi, or protozoa. Herpes ...
What is a corneal transplant?. A corneal transplant is where the abnormal cloudy or scarred patients cornea is removed and a donor cornea (the clear window on the front of the eye, which has been obtained from someone who has donated their cornea) replaces the abnormal patients cornea.. When is a corneal transplant needed?. A corneal transplant may be needed when the cornea is permanently scarred, or the corneal shape is very abnormal (as in keratoconus) or when the endothelial pumping cells at the back of the cornea are not functioning well (as in Fuchs dystrophy). A corneal transplant (also known as a corneal graft) is only worth doing when the inside of the eye (retina and optic nerve) is still functioning well. The camera analogy is that there is no purpose in replacing the clear lens in the camera if the photographic components are not working. Conditions that may have damaged the inside of the eye are glaucoma, optic nerve disease, retinal detachment, severe inflammation or infection ...
PK is limited to use in diseases where the benefit of replacing all the disease tissue will provide the best optical or therapeutic results compared with lamellar keratoplasty," he said.. Dr Fourniés talk was followed by a presentation by Dr Vincent Borderie on deep anterior lamellar keratoplasty (DALK).. In a wide-ranging look at the indications and advantages of DALK, Dr Borderie discussed its utility in cases such as keratoconus, infectious keratitis, stromal dystrophies, after corneal trauma and in eyes with failed graft after previous penetrating keratoplasty.. Overall, the technique offers a lot of advantages to modern transplant surgeons, he said. "DALK is associated with higher endothelial cell survival, lower rejection rate, lower glaucoma incidence and higher predicted long-term graft survival. The gold standard is a recipient bend made of Duas layer, Descemets membrane and endothelium. Air injection and intraoperative optical coherence tomography are useful to reach this goal," he ...
Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection.s profile, publications, research topics, and co-authors
Graft rejection occurs in 5-30% of patients, a complication possible with any procedure involving tissue transplantation from another person (allograft). Allograft rejection results from a reaction of the patients immune system to the donor tissue. Cell surface proteins called histocompatibility antigens trigger this reaction. These antigens are often associated with vascular tissue (blood vessels) within the graft tissue. Because the cornea normally contains no blood vessels, it experiences a very low rate of rejection. Generally, blood typing and tissue typing are not needed in corneal transplants, and no close match between donor and recipient is required. However, the Collaborative Corneal Transplantation Study found that patients at high risk for rejection could benefit from receiving corneas from a donor with a matching blood type ...
The purpose of this study is to test the effectiveness of a drug, bevacizumab (Avastin), in preventing blood vessels that often occur after a corneal transplantation which are considered at high-risk for rejection. In many cases these blood vessels lead to the graft rejection and eventual failure of the corneal transplant. It is hoped that this treatment will increase the chances of corneal graft survival.. The medication used in this study is called bevacizumab or Avastin (Genentech, Inc). It works by inhibiting the action of a molecule called vascular endothelial growth factor (VEGF). VEGF is a substance molecule that binds to certain cells to stimulate new blood vessel formation. When VEGF is bound to the drug, it cannot stimulate the formation and growth of new blood vessels. Growth of blood vessels into the cornea is a complication which can worsen the prognosis of your corneal transplant and put the transplant at a higher risk for rejection. ...
What is Cornea?. Cornea is the transparent part of the eye in front which allows light to enter the eye and helps in forming a clear image.. What is corneal transplantation?. A corneal transplant involves replacement of a damaged cornea with a healthy one from a donor. An unhealthy cornea affects the vision by either not allowing light to enter the eye or causing significant scattering or distortion of light. This causes blurry vision. A cornea transplant is required in these cases to restore functional vision.. Sometimes diseases of the cornea including infections can cause significant weakening of the cornea. In these cases corneal transplants are performed in order to protect the integrity of the eye, relieve pain and remove the diseased cornea.. Who all can benefit from corneal transplantation?. Corneal transplantation may be required in various eye diseases which can include the following:. • Opacities in cornea due to previous infections such as corneal ulcer, herpes of the eye or eye ...
There have been a number of advances in Ophthalmology in the management of the aging eye. This video discusses corneal transplantation - penetrating keratoplasty vs endothelial keratoplasty; cataract surgery - manual vs femtosecond laser assisted cataract surgery; glaucoma surgery - trabeculectomy vs microinvasive glaucoma surgery and vitreolysis - vitrectomy vs YAG vitreolysis. Technology is advancing, but keep a healthy skepticism.. ...
The cornea is the transparent, dome-shaped window covering the front of the eye that lets in light and helps focus it on the retina so that we can see. Disease or injury can make the cornea cloudy or distorted in shape, causing loss of vision. When this happens patients are offered a corneal transplantation which requires a continuous supply of healthy donor corneas.. However, worldwide demand has grown and, taken together with an aging population and the rapid rise in laser eye surgery (which can negatively affect the donor tissue suitability for transplantation), the search for an effective engineered replacement is essential if current levels of corneal transplantation are to be maintained.. More than 48,000 cornea transplants have been recorded on the UK Transplant Registry since the Corneal Transplant Service began in 1983.. Dr Che Connon, from the Reading School of Pharmacy at the University, will be working with Professor Ian Hamley in the Department of Chemistry to engineer a tissue ...
Corneal Transplantation A corneal transplant is a surgical procedure to replace the central portion of your cornea with corneal tissue from a donor. A corneal
Purpose: The goal of this study was to report on the advantages and limitations of the pig and feline models for experimental in vivo corneal transplantation. Methods: Ten healthy domestic pigs and ten healthy cats were used. Full thickness penetrating keratoplasty was performed using autologous (eight cases), allogeneic (seven cases) or human xenogeneic (three cases) tissue. In two other cases, the inflammatory response to partial thickness trephination (without transplantation) was evaluated. Eyes were assessed daily before and after surgery by slit-lamp, pachymetry, and tonometry. A transparency score ranging from 0 (opaque graft) to 4 (clear graft) was used, based on the slit-lamp examination. Optical coherence tomography, histology, and electron microscopy were performed postmortem. Results: In the pig, the mean (±SD) transparency score for the eight full thickness grafts was 0.88 ± 0.99, ranging from 0 to 3. In the feline model, the mean transparency score for the seven uncomplicated ...
Looking for Cornea Transplant? Choose from 12 clinic(s) offering Cornea Transplant treatment in 10 countries. Get quotes fast & choose the best.
This presentation by Dr. Roger Steinert reviews the use of femtosecond laser for the creation of incisions in corneal transplantation procedures.
A visually impaired man from southern China has had his eyesight restored—after a successful corneal transplantation from a most ‘unexpected’ donor.
Are you looking for a specialist in the field of Corneal transplantation? Here you will find selected specialists in Germany, Austria or Switzerland
Mean preoperative visual acuity was 0.29 ± 0.18 in the big-bubble group and 0.25 ± 0.15 in the microbubble group. Postoperatively, all patients showed a regular interface between donor and recipient tissue. At 24 months, mean best-corrected visual acuity was 0.84 ± 0.16 in the big-bubble group and 0.68 ± 0.17 in the microbubble group (p = 0.013), and mean central corneal thickness was 530 ± 39 µm in the big-bubble group and 545 ± 30 µm in the microbubble group. Astigmatism was 2.41 ± 1.29 D and 3.59 ± 1.48 D (p = 0.036), respectively, while endothelial cell density was 1,671 ± 371 in the big-bubble group and 1,567 ± 275 in the microbubble group.. ...
This page provides relevant content and local businesses that can help with your search for information on Corneal Transplant Surgery. You will find informative articles about Corneal Transplant Surgery, including Corneal Transplant Eye Surgery. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Cary, NC that can help answer your questions about Corneal Transplant Surgery.
This page provides relevant content and local businesses that can help with your search for information on Corneal Transplant Surgery. You will find informative articles about Corneal Transplant Surgery, including Corneal Transplant Eye Surgery. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Paragould, AR that can help answer your questions about Corneal Transplant Surgery.
Corneal transplant surgery is the most commonly performed of all transplant operations, with approximately 45,000 corneal transplant procedures being performed in the Unites States each year. The indications for corneal transplant surgery have changed through the years. Pseudophakic bullous keratopathy and aphakic bullous keratopathy (corneal edema secondary to cataract surgery) accounted for 80% of corneal transplants in the 1980s. However, with the improvement of cataract surgery techniques, conditions such as Fuchs Dystrophy, Keratoconus, and other corneal dystrophies are now more commonly transplanted.. In 1933, corneal transplants were performed using two razor blades to make a square graft. Patients were hospitalized for two weeks with sand bags on either side of their head to prevent undesirable movement and possible leakage from the wound sites. Since then, there have been major advances in surgical technique including the introduction of the operating microscope (1970s) and better ...
A cornea transplant, which replaces damaged tissue on the eyes clear surface, also is referred to as a corneal transplant, keratoplasty, penetrating keratoplasty (PK) or corneal …
Dr. Fram received her medical degree from Thomas Jefferson University, Jefferson Medical College in Philadelphia, Pennsylvania and was elected to the Alpha Omega Alpha (AOA) National Honor Medical Society. She completed her residency at the prestigious Wills Eye Institute in Philadelphia, Pennsylvania where she served as Chief Resident. Following her residency, Dr. Fram completed a one-year fellowship in Cornea, External Disease and Uveitis at the Francis I. Proctor Foundation, University of California, San Francisco (UCSF) where her research interests included innovative corneal transplantation techniques including Descemets Stripping Automated Endothelial Keratoplasty (DSAEK) and Deep Anterior Lamellar Keratoplasty (DALK). Dr. Fram is an active member of the American Academy of Ophthalmology and The Castroviejo Cornea Society ...
Dr. Fram received her medical degree from Thomas Jefferson University, Jefferson Medical College in Philadelphia, Pennsylvania and was elected to the Alpha Omega Alpha (AOA) National Honor Medical Society. She completed her residency at the prestigious Wills Eye Institute in Philadelphia, Pennsylvania where she served as Chief Resident. Following her residency, Dr. Fram completed a one-year fellowship in Cornea, External Disease and Uveitis at the Francis I. Proctor Foundation, University of California, San Francisco (UCSF) where her research interests included innovative corneal transplantation techniques including Descemets Stripping Automated Endothelial Keratoplasty (DSAEK) and Deep Anterior Lamellar Keratoplasty (DALK). Dr. Fram is an active member of the American Academy of Ophthalmology and The Castroviejo Cornea Society ...
This is the newest type of corneal transplantation that is only being done at a limited number of locations. During this procedure, Dr. Aaker will remove the cells in the back of the cornea and replace them with the identical tissue from the donor (1/100th of a millimeter thick) which is attached with an air bubble. The front of the cornea is left unchanged except for a small incision. This surgery usually only requires one stitch compared to sixteen or more for a typical cornea transplant. Vision returns much quicker after this surgery and there often is complete visual rehabilitation by four weeks. The highest percentage of patients are corrected to 20/20 after this surgery compared to other types of corneal transplants. This is usually the preferred transplant for Fuchs dystrophy. ...
Faster recovery times and better visual outcomes are among the early results of a corneal transplant pilot study underway at the University of Michigan Kellogg Eye Center. The focus of this two-year pilot program - called the Femtosecond Laser Assisted Keratoplasty study, or FLAK - is the use of the ultrafast or femtosecond laser in performing full thickness corneal transplants.. Researchers at Kellogg were first to discover in the early 1990s that the femtosecond laser, then used for industrial purposes, had great potential for eye surgeries that traditionally required a surgical blade or knife. Through joint efforts of faculty from Kellogg and the U-M College of Engineering, the femtosecond laser was further developed, and is widely used for refractive surgery. Now, experts hope for the same success in applying this exceptionally fast and precise laser to cornea transplant surgery.. "We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of ...
Cornea Transplant India ,The greatest risk with corneal transplants is rejection, although this can be treated with immunosuppressive medicine if caught in the early stages.. #633085
With improvements in technology we can expect the number of corneal grafts to decrease. Modern lens implant design, viscoelastic materials, and improved antimicrobial agents have all made an impact in this respect. But the need for keratoplasty remains and with it the vexing problem of how to deal with the "high risk" cornea.. The cornea has long been recognised as having "immunological privilege" but in vascularised corneas and possibly corneas that have previously rejected a graft, this privilege breaks down and the cornea becomes as susceptible as any other vascularised tissue in the body to rejection. These corneas have been referred to as "high risk" and special precautions need to be taken to prevent or minimise rejection. When attempting to establish the optimal treatment for these corneas, the first hurdle remains the definition of a "high risk" cornea. This question has been explored before and is touched upon in a paper by Rumelt and colleagues published in this issue of the BJO (p ...
Cataract surgery, refractive lens surgery, new intraocular lens technology - toric and multifocal intraocular lenses, corneal transplant - DSAEK partial thickness corneal transplant endothelial keratoplasty and DALK - deep anterior lamellar keratoplasty, LASIK and LASEK, intraocular lens for visually impaired patients - IOLVip ...
As a secondary objective, this study also aims to establish the corneal and anterior chamber concentration of ranibizumab when delivered subconjunctivally at the limbus in patients undergoing corneal transplantation. The effects of ranibizumab on corneal epithelial healing will be examined following adjunctive use in corneal transplantation. Finally, clinical characteristics including recurrent corneal neovascularization will be studied ...
Purpose: Catquest-9SF is a 9-item visual disability questionnaire developed for evaluating patient-reported outcome measures after cataract surgery. The aim of this study was to use Rasch analysis to determine the responsiveness of Catquest-9SF for corneal transplant patients. Methods: Patients who underwent corneal transplantation primarily to improve vision were included. One group (n = 199) completed the Catquest-9SF questionnaire before corneal transplantation and a second independent group (n = 199) completed the questionnaire 2 years after surgery. All patients were recorded in the Swedish Cornea Registry, which provided clinical and demographic data for the study. Winsteps software v.3.91.0 (Winsteps.com, Beaverton, OR) was used to assess the fit of the Catquest-9SF data to the Rasch model. Results: Rasch analysis showed that Catquest-9SF applied to corneal transplant patients was unidimensional (infit range, 0.73-1.32; outfit range, 0.81-1.35), and therefore, measured a single underlying ...
Why do some corneal transplants fail - How do corneal transplants work? Expai. A donor cornea is identified. Surgery consists of taking of the patients cornea and placing the donor cornea in its place. The donor cornea is secured with very small sutures.
SEATTLE -- About 10 million people worldwide are currently waiting for cornea transplants, according to SightLife, a local nonprofit. And every donor makes a big difference. March is National Eye Donor Month.
Doctors use cornea transplants to treat vision loss due to scarring or disease. During the procedure, the surgeon replaces the damaged outer lens of the eye using tissue of a recently deceased...
Doctors for corneal surgery in Bangalore, find doctors near you. Book Doctors Appointment Online, View Cost for Cornea Transplant in Bangalore | Practo
Following a cornea transplant, you should be able to return to work within a week. However, complete recovery can take up to a year or longer.
Aimlbackground-The public health significance of corneal transplantation in dealing with corneal blindness in the developing world would depend upon the survival rate of transplants. This study was done to analyse the survival rate of corneal transplants in a large series in India, and to evaluate the influence of various risk factors on...
Once you and your doctor have decided that a corneal transplant is the best option to restore your functional vision, your name is placed on a list at a local eye bank. The waiting period for a donor eye is generally one to two weeks due to a very sophisticated eye bank system in the U.S. Before donor corneas are released for transplant, tissue is checked for clarity. Also, donor eyes supplying transplant tissue are meticulously screened for presence of diseases such as hepatitis and AIDS or other damage to ensure the health and safety of the recipient.. Typically, corneal transplants are performed on an outpatient basis, meaning that you will not need hospitalization. Local or general anesthesia is used, depending on your health, age, and whether or not you prefer to be asleep during the procedure. With local anesthesia, an injection into the skin around your eye is used to relax muscles that control blinking and movement, and eye drops are used to numb the eye itself.. After the anesthesia has ...
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A Randomized Clinical Trial. "Over the past 20 years, corneal transplant specialists have gotten comfortable only using corneas up to one week after they are stored. But our findings show they can safely use them up to 11 days after first being stored," said Lass, Charles I Thomas Professor in the Department of Ophthalmology and Visual Sciences at Case Western Reserve School of Medicine, member of the University Hospitals Eye Institute, and lead investigator of the national Cornea Preservation Time Study, which produced the results. "This will help to meet the expected future demand for corneas in this country as well as in patients overseas today, who now receive as many as thirty percent of corneas donated by U.S. citizens.". Patients who need corneal transplants are typically age 50 and older. According to projections by the U.S. Census Bureau, that population will grow from about 109 million currently to about 133 million by 2030 in this country.. The cornea, the eyes clear outer covering, ...
Corneal transplant surgeries in young patients resulted in improved vision and thereby a better living, says a study. Success rates of corneal transplants in kids was also high.
Cornea Graft Treatment in top hospitals in Iran. Compare prices & reviews. Get online consult from board certified doctors - AloMedical.com
Undergoing a corneal graft operation can be nerve-wrecking especially if you are thinking about the risk of rejection in the surgery. It is notable to consider, however, that 90 percent of corneal graft operations are actually successful. In order to contribute to the success of the operation, keep in mind that even if the eye surgeon has a credible record of prosperous surgeries, he will still need your full cooperation, before, during and after the operation.. Preparation. Before the surgery will take place, you will still need to undergo several medical examinations that will help the medical team in evaluating your condition.. • Report any related eye-condition. Corneal graft entails a surgery wherein your eyes must remain still during the entire period, lest it will hinder the success of the operation. If you have any involuntary eye conditions, it would be best to report it to the eye surgeon so that he can provide the necessary action before the surgery can take place ...
There are about 48,000 corneal transplants done each year in the U.S., compared to approximately 16,000 kidney transplants and 2,100 heart transplants 12. Out of the 48,000 corneal transplants done, 10 percent of them end up in rejection, largely due to poor medication compliance. The nanoparticle loaded with medication could eliminate the need for a patient to remember to take their medicine - often multiple doses per hour - after a surgery, alleviating compliance risk. These types of drug delivery systems could be paired with other drugs and used in other conditions, such as glaucoma, macular degeneration and corneal ulcers, among others.. Read the entire article here ...
In their article in this issue of the BJO (p 57) Saunders and colleagues describe a methodology by which they evaluate the visual health state of patients with severe corneal disease requiring transplantation surgery. Rather than dealing with visual acuity as the only preoperative and outcome parameters, they evaluate patients according to three criteria: (1) visual acuity, (2) ocular pain, and (3) visual function. Concerning the latter criterion, visual function, they utilise a tool called the VFA (visual function assessment),1 which they have previously described; it is essentially a modification of the VF-142 and predominantly measures ocular function characterised by the ability to perform tasks such as driving, reading, cooking, etc. They found that patients who had a high preoperative priority score, as measured by the three above criteria, were more likely to have a good outcome. One measure in the study that is somewhat unclear, though, is how the results incorporate vision in the eye ...
Sigma-Aldrich offers abstracts and full-text articles by [Jing Hua, Yiping Jin, Yihe Chen, Takenori Inomata, HyunSoo Lee, Sunil K Chauhan, Nicos A Petasis, Charles N Serhan, Reza Dana].
A cornea transplant can be carried out under general anaesthetic (where you are unconscious) or local anaesthetic (where the area is numbed and youre awake). The procedure usually takes less than an hour and, depending on your circumstances, you either leave hospital the same day or stay overnight. If the procedure involves the transplantation of the outer cornea, the new outer cornea is held in place with stitches, which usually stay in for more than 12 months. An endothelial transplant (EK) doesnt require stitches. Its held in place by an air bubble until a few days later, when it naturally sticks to the deep layer of the cornea.. In most cases, a cornea transplant procedure lasts less than an hour.. Read more about how cornea transplants are performed.. ...
View Video The cornea is the clear covering of the front of the eye. It provides most of the refractive power of the eye, although this power is fixed. The cornea is the target for refractive surgical procedures such as LASIK and PRK.
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Definition Corneal Transplantation is a surgical procedure whereby a damaged or diseased cornea is replaced by a clear cornea. The cornea is the clear front
Treating donor corneas with a cocktail of molecules prior to transplanting to a host may improve survival of grafts and, thus, outcomes in high-risk corneal transplant patients, according to a new study led by researchers at Massachusetts Eye and Ear.
Pig eye transplant: Chinese boy saved from blindness by porcine cornea By Léa Surugue, International Business Times March 11, 2016 15:47 GMT Pig cornea transplants are carried out in China.(Getty Images) In China, a 14-year-old boy...
A corneal transplant involves replacing a diseased or scarred cornea with a new one. When the cornea becomes cloudy, light cannot penetrate the eye
Corneal transplants can help someone who is blind see again. To find out about eligibility and procedures read here and then call your eye doctor.
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Join us as Neil Griffin, M.D., leading ophthalmologist with Griffin Eye Center, answers the following questions related to cataracts and corneal transplants: What is a cataract and how is cataract surgery performed? What are the new options in cataract surgery? Are you a cornea transplant candidate? What is a corneal transplant and what type of surgeries are performed?. Dr. Griffin is board certified and fellowship trained in cornea and external disease.. The Richmond Education Series is free and open to the public and will be held in the cafeteria at Richmond Memorial Hospital. Refreshments will be served.. For more information or to register, call (800) 213-3284 or register below.. ...
Life is precious. Too precious to be lost to an organ failure. But millions have lost their lives because a vital organ failed to function in their body. Medical science has made it possible to transplant organs & tissues from one person to another. And to think that all you need to help life continue is simply pledge for donation and donate an organ when you leave this world.. There is a huge gap between demand and supply of human organs and tissues. In our country, 1-1.5 lac patients require kidney transplantation but only 3500-4000 patients receive it. Similarly, 1 lac patients are in need of corneal transplantation but only 25000 patients undergo corneal transplant. In case of heart transplantation, the scenario is much more dismal in our country.. There is lack of awareness about deceased organ and tissue donation except corneas in the society. Acute shock due to the sudden loss of near and dears, non-acceptance of brain death as death, religious myths, fear of disfigurement and divided ...
As a newly minted ophthalmologist in the 1980s, Dr. Roger Steinert was intrigued by exotic lasers being developed in France and Switzerland to cut and reshape eye tissue. But nobody had systematically explored how to use them safely for eye surgery or develop their potential.. Steinert, then a junior faculty member at Harvard Medical School, made it his passion to unlock the power of those lasers. For the past three decades, Steinert, now director of UC Irvines Gavin Herbert Eye Institute, investigated their use and pioneered new laser surgery techniques to stave off blindness and strengthen eyesight. Now one of the worlds foremost experts in the fields of cataract surgery, corneal transplantation and laser refractive vision correction, Steinerts early work with lasers helped lay the foundation for LASIK surgery. More recently, he and his colleagues developed a groundbreaking approach to corneal transplant surgery that is more precise and leads to better outcomes and faster recoveries than ...
Cornea and tissue transplant recovery differs from organ recovery. For more information about corneal and tissue donation and transplantation, click here.
Researchers in the Department of Materials Science and Engineering and the L.V. Prasad Eye Institute, Hyderabad have announced the approval by the Indian Regulatory Authority of the first in-man clinical trials of their jointly developed new technique, delivering stem cell therapy into the eye to address the loss of vision due to scarring of the cornea.. After more than 4 years of collaboration between the organisations in India and the UK, the Wellcome Trust-funded trials will begin in India in Autumn 2015 and involve 10 patients, all of whom have sustained injuries to one of their eyes, primarily through either industrial or cooking accidents, causing chemical burns.. They will be treated by using a very small piece of tissue from the patients unaffected eye. This is cut into about 8/10 small pieces (which contain the corneal stem cells) and lightly attached to a synthetic biodegradable membrane which is then placed onto the damaged eye. This membrane, made of the same material as dissolvable ...
Tanvi Eye Hospital Hyderabad, Secunderabad, Marredpally is giving services like Blind Relief Camps, Cataract Operation, Corneal Grafting, Eye Donation Awareness Programmes and having departments Contact Lens, Squint & Amblyopia, OPD, Vitreo-Retinal Clinic, FFA, Laser Clinic, Operation Theatre, Optical and Drug Dispensing, Glaucoma Investigation etc.
This database has assisted in making many discoveries by allowing us to see trends-whats working well and whats not working so well, so we can continually refine surgical techniques and patient care resulting in better outcomes. We use this database to assist us in identifying areas in which more research is needed. Here are just a few examples illustrating how this database has proven invaluable:. ...
This database has assisted in making many discoveries by allowing us to see trends-whats working well and whats not working so well, so we can continually refine surgical techniques and patient care resulting in better outcomes. We use this database to assist us in identifying areas in which more research is needed. Here are just a few examples illustrating how this database has proven invaluable:. ...
Tanvi Eye Hospital Hyderabad, Secunderabad, Marredpally is giving services like Blind Relief Camps, Cataract Operation, Corneal Grafting, Eye Donation Awareness Programmes and having departments Contact Lens, Squint & Amblyopia, OPD, Vitreo-Retinal Clinic, FFA, Laser Clinic, Operation Theatre, Optical and Drug Dispensing, Glaucoma Investigation etc.
DeSoto EyeCare is your local ophthalmologist in Southaven serving all of your vision care needs. Call us today at (662)-349-1959 for an appointment.
You should write a verse, too. Stevens claims to have written his first verse when he was 12 years old, to the beat of Twista s " Emotions ": Hip Hop Songs Latest Songs Popular Songs Archive. Did you even listen to Control System? NEXT ARTICLE Lil Uzi Vert Says Hes Working With Kanye West On New Music Lil Uzi Vert is putting in work with Ye. I called my homie and was like "I think Im going to write a verse to this, man. I wasnt too set on being a rapper just yet at 15, it was just some real cool shit. But I know early on, I really, really liked Michael Jackson, like we all did. Five… What was that, Nintendo? Book of ra kartentrick, Twenty-Five-Years Old "Man… At 25, I lost my world and I got the wimmelbider at the same time. Yo iCarly when you gonna let Lil Pump fuck??? So, working with words in that manner was very fun. You get impatient to the point where you have to tell yourself, Just give it some time. And it was very, very life-changing for me. Wasnt until after I graduated from ...
Purpose: To establish a cornea transplant model in a pigmented rat strain and to define the immunologic reaction toward corneal allografts, by studying the cellular and humoral immune response after keratoplasty. Methods:Full ...
Disease, Eye, Cells, Eye Disease, Transplantation, Cell, Inflammation, Cornea, Corneal Transplantation, T Cells, Graft, Role, Inhibition, Lymph, Therapeutic, Survival, Donor, Endothelial Growth Factor, Vascular Endothelial Growth Factor, Lead
Highly skilled ophthalmologist, Dr. Asim Farooq, provides comprehensive care for a wide range of eye conditions, including cataract surgery, corneal transplantation surgery, and correcting common vision disorders (nearsightedness, farsightedness and astigmatism) using refractive surgery.
As Just about the most competent and experienced laser vision correction doctors while in the Philadelphia spot, Dr. Columbus has devoted a few years of examine and education to establishing the scientific competencies and expertise necessary to perform corneal transplantation, cataract surgery, and other eye methods. He received his healthcare degree from Penn State College, where by he check here also done his interior drugs residency ...
Reorienting and grafting of scarred tip structures has restored appropriate triangularity to the tip. Remeijer L, Maertzdorf J, Doornenbal P, et al Herpes simplex virus 1 transmission through corneal transplantation.
Ophthalmologist specialising in cataract, refractive surgery and corneal transplantation which he performs in Johannesburg, South Africa. ...
You will arrive at the Eye Institute at the Medical Center Clinic 30-60 minutes prior to your procedure. Once you have been checked in you may be offered a sedative to help you relax. You will then be prepared for surgery. The area around your eyes will be cleaned and a sterile drape may be applied around your eye. Your eye will be numbed with topical or local anesthetics. When your eye is completely numb, an eyelid holder will be placed between your eyelids to keep you from blinking during the procedure.. Your diseased cornea will be removed with a special round tool called a trephine. Then the donor cornea will be cut to a matching size, placed upon your eye and secured in place with very fine sutures. Your eye will be patched or shielded after surgery.. The surgery itself is painless and usually done on an outpatient basis. The operating time is approximately 60-90 minutes, followed by a short recovery time. You will be allowed to go home soon afterward. You should relax for the rest of the ...
Since January 2009, Héma-Québec has been responsible for the donor qualification process, collection of eyeballs and regulatory framework governing these activities. Added to these responsibilities is oversight of the process for assigning corneas to surgeons, a role that naturally falls within the range of activities already carried out by the organization. Héma-Québec assumed this mandate following a partnership agreement with Maisonneuve-Rosemont Hospital for the management of the Québec Eye Bank in Montréal. A similar partnership agreement reached in the Québec City region with the Centre hospitalier affilié universitaire de Québec (CHA) will come into effect on January 1, 2012.. "Improving the supply of corneas to medical specialists has had a real impact in the field. The 2009 partnership agreement between the Québec Eye Bank in Montréal and Héma-Québec has truly produced results. This alliance has made it possible to better respond to the needs of patients waiting for a ...
When the cornea becomes cloudy or misshapen from injury, infection or disease, transplantation may be recommended to replace it. Learn more here.
The cornea is the eyes outermost layer. It is a clear dome of tissue that allows light to enter the eye. If the cornea becomes diseased or damaged, it can distort or even block the normal path of light into the eye. When this happens, light does not focus normally on the retina, the layer at the back of the eye that
The cornea in your eye is a dome-shaped, transparent surface that helps you focus on objects in your vision. Corneal damage and disorders are not just the 4th leading ...
I want to credit the insight given to me from Dr. Doug Rett, OD, FAAO:. "In 1958 Muro Pharmacal Labs was founded and it manufactured ophthalmic drugs. It was named Muro for the Italian word for "wall," which I think is fitting given the barrier that the cornea plays in penetration of ocular drugs. With tight junctions, pH sensitivity and the hydrophobic nature of the epithelium and hydrophilic nature of the stroma, its difficult for modern-day drug companies to pass medication through the cornea, let alone in the 1950s. In 1968 Muro was sold to George Behrakis, a pharmacist from Lowell, […]. ...
The researchers found that donor rim culture results were three times more likely to be positive for fungi in endothelial keratoplasty-processed eyes (1.14%) compared with other uses (0.37%).
No matter your procedure or your technique, KeraLink International is committed to providing you with highest-quality ocular tissue services.. With convenient, safe online ordering, quick delivery of the tissue you need for your next corneal transplant is just a click away.. Please log in or register with KeraLink International to request ocular tissue.. Log In Sign Up ...
Background & Aims: This study was carried out to determine the leading indications for corneal transplantation in Kerman province. Methods: Medical records of 186 patients underwent corneal transplantation during 3 years (2004-2006) in Shafa Medical Center were evaluated retrospectively. The initial diagnosis and causes of corneal grafting were recorded. Infectious keratitis (Bacterial, Fungal, and acanthamoeba keratitis), corneal opacity and scarring, keratoconus, bullous keratopathy, regrafting, corneal dystrophy and degeneration, herpes simplex keratopathy (active keratitis), etc. were considered as indications of corneal transplantation. Results: A total of 186 patients (110 males, 76 females) were included in the study. Mean age of patients was 47.7± 24.3 years (6-85). The leading indications of grafting was corneal opacity (32.3%) followed by keratoconus (22.6%), bacterial keratitis (15.6%), aphakic bullous keratopathy (6.7%), pseudophakic bullous keratopathy (6.5%), regrafting (4.8%), herpes
Macular corneal dystrophy (MCDC; sometimes also Fehr corneal dystrophy) is a rare pathological condition affecting the stroma of cornea. The first signs are usually noticed in the first decade of life, and progress afterwards, with opacities developing in the cornea. There is also a predisposition to developing painful recurrent corneal erosions. MCDC is inherited in autosomal recessive fashion and is thought to be caused by the lack or abnormal confuguration of keratan sulfate. Most cases of MCD are caused by mutations in CHST6 gene. The condition was first described by Arthur Groenouw in 1890.. Alan N. Carlson, M.D., Professor of Ophthalmology and Chief of the Corneal and Refractive Surgery Service at the Duke Eye Center demonstrates the basic techniques behind successful corneal transplantation (penetrating keratoplasty) in a patient with visually significant corneal opacification from Macular Corneal Dystrophy.. ...
Cornea Transplant,Eye Transplant, Corneal Transplant Surgery,After Corneal Transplant,Corneal Transplant Recovery,Transplant Rejection, Michael Duplessie
Read our latest blog post: Why you might need a cornea transplant. Call Central Florida Eye today for more information and to schedule your appointment.
The Heartland Lions Eye Banks recently recognized Fayette County Hospital for its efforts to promote eye donations. Because of the hospital staffs efforts, three eye donors provided tissue for three sight-saving corneal transplants during 2010. Last year, more than 2,800 people suffering from an ocular disease, disorder or injury received a cornea transplant through Heartland Lions Eye Banks. Those donations are being praised during March, which is National Eye Donor Month.
The Heartland Lions Eye Banks recently recognized Fayette County Hospital for its efforts to promote eye donations. Because of the hospital staffs efforts, three eye donors provided tissue for three sight-saving corneal transplants during 2010. Last year, more than 2,800 people suffering from an ocular disease, disorder or injury received a cornea transplant through Heartland Lions Eye Banks. Those donations are being praised during March, which is National Eye Donor Month.
Faculty directly responsible for education and training in this fellowship include Dr. Davis, Dr. Rhea Siatkowski, and Dr. David Jackson, Drs. Davis and Siatkowskis practices in cornea and external diseases are similar, and include patients with infectious, inflammatory, neoplastic, traumatic, and degenerative disorders of the cornea, ocular surface, and anterior segment. Recent fellows have performed over 40 penetrating and deep anterior lamellar keratoplasties, 50 DSAEK, 100+ phaco/IOL, and 15-30 refractive surgeries as primary surgeon. Additional expertise will be developed in secondary lens implants, iris reconstruction, keratoprostheses, ocular surface reconstruction, limbal stem cell transplantation, ocular surface neoplasm excision, and in oculoplastic procedures relevant to the treatment of corneal diseases.. In addition to this exposure to a tremendous breadth and depth of cornea and external disease pathology, the fellow also will participate in the evaluation and management of ...
A corneal transplant involves the removal of the central portion of the diseased cornea and replacing it with a donor, cadaver cornea. The donor cornea is held in position with fine sutures or stitches. The healing process that follows can take a year or longer. It is common to experience large amounts of astigmatism or irregular astigmatism which require correction with RGP contact lenses. This defeats the purpose of having the transplant. Some patients may be a candidate for PRK after 1 year. Cornea transplant surgery is very invasive and carries significant risks such as graft rejection, cataract, infection, and retina detachment.. The "dirty little secret" about cornea transplants is that the cornea is NEVER as strong as a cornea without a transplant. Unfortunately, most transplant surgeons will not tell patients about this risk. After a transplant, even a little bump or hit to the eye can rip open the edges of the cornea and delicate internal structures can come out (eg iris, natural lens, ...
PurposeTo evaluate the refractive and visual results of one-stage laser-assisted in situ keratomileusis with femtosecond laser (Femto-LASIK) for the correction of residual ametropia after deep anterior lamellar keratoplasty (DALK).MethodsThis retrospective study included 13 eyes of 12 patients, who underwent corneal Femto-LASIK to correct refractive errors after DALK. IntraLase FS150 was used to create a lamellar flap and excimer laser ablation for refractive correction was performed using the Star S4 IR Excimer Laser in eight cases and the Technolas 217z Excimer Laser in Tissue Saving mode in five cases ...
Pre Descemets endothelial keratoplasty (PDEK) is a kind of endothelial keratoplasty, where the pre descemets layer (PDL) along with descemets membrane (DM) and endothelium is transplanted. Conventionally in a corneal transplantation, doctors use a whole cornea or parts of the five layers of the cornea to perform correction surgeries. In May 2013, Dr Harminder Dua discovered a sixth layer between the stroma and the descemet membrane which was named after him as the Duas layer. In the PDEK technique, doctors take the innermost two layers of the cornea, along with the Duas layer and graft it in the patients eye. The normal cornea (Fig 1) has from the front to the back the following layers: 1. Epithelium 2. Bowmans membrane 3. Stroma 4. Pre Descemets layer 5. Descemets membrane 6. Endothelium For the human eye to see, the cornea or the front window of the eye should be clear or transparent. For that to happen the inside corneal layer the endothelium pumps out water from the cornea so that the ...
TY - JOUR. T1 - Penetrating keratoplasty for herpes simplex keratitis and keratoconus. T2 - Allograft rejection and survival. AU - Epstein, R. J.. AU - Seedor, J. A.. AU - Dreizen, N. G.. AU - Stulting, R. D.. AU - Waring, G. O.. AU - Wilson, L. A.. AU - Cavanagh, Harrison D. PY - 1987. Y1 - 1987. N2 - To determine the relationship between corneal allograft rejection and failure, we studied patients who underwent penetrating keratoplasty for herpes simplex keratitis (n = 82) and keratoconus (n = 345), two frequent indications for keratoplasty in young patients, using survival analysis. For first grafts for herpes, the probability of survival was significantly less than it was for keratoconus (P , 0.0001). For second grafts, this difference was less pronounced, and for three or more grafts, the difference in survival was not significant. The incidence of rejection episodes was similar in first grafts for herpes (16.6%) and keratoconus (18.5%) (P , 0.05). However, the incidence of rejection ...
To present a method, alternative to penetrating keratoplasty, for the restoration of impaired corneal clarity with anterior stromal scarring following long-standing corneal graft failure. A 48-year old female who had previously underwent Descemet stripping automated endothelial keratoplasty (DSAEK) for the treatment of pseudophakic bullous keratopathy, presented with long-standing corneal oedema and anterior corneal scarring. A significant improvement in corrected distance visual acuity was demonstrated, as corneal clarity was restored following graft exchange and phototherapeutic keratectomy (PTK). The combination of corneal graft exchange and phototherapeutic keratectomy may represent an effective therapeutic option for long-standing corneal oedema with concomitant anterior corneal scarring after failure of a DSAEK graft.
Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive anesthesia (a complete eye block or general anesthesia). Although widely used, safety concerns have been raised over MMC in the treatment of pterygia.Objective: The objective of this case report is to report the successful use of preoperative subconjunctival injection of low-dose (0.02%) MMC one month before bare sclera excision of a multirecurrent pterygium, as well as the concomitant intraoperative application of MMC to the conjunctival
Gelatinous drop-like corneal dystrophy, also known as amyloid corneal dystrophy, is a rare form of corneal dystrophy. The disease was described by Nakaizumi as early as 1914. The main pathological features in this dystrophy are mulberry-shaped gelatinous masses beneath the corneal epithelium. Patients suffer from photophobia, foreign body sensation in the cornea. The loss of vision is severe. The amyloid nodules have been found to contain lactoferrin, but the gene encoding lactoferrin is unaffected. This form of corneal amyloidosis appears to be more frequent in Japan. A number of mutations causing this disease have been described in the M1S1 (TACSTD2) gene encoding Tumor-associated calcium signal transducer 2, but not all patients have these mutations, suggesting involvement of other genes. Recurrence within a few years occurs in all patients following corneal transplantation. Soft contact lenses are effective in decreasing recurrences. Nakaizumi, K. : A rare case of corneal dystrophy. Acta. ...
Case Report DOI:10.14744/bej.2019.79553 Beyoglu Eye J 2019; 4(2): 126-129 Manual Intracorneal Silicone Oil Insertion for Symptomatic Treatment of Bullous Keratopathy in a Patient with Corneal Scarring Selim Genc, Semih Cakmak, Yusuf Yildirim Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Abstract Bullous keratopathy is a result of endothelial loss and the failure of the remaining corneal epithelium to pump leaking water molecules away from the corneal tissue, causing overhydration. In eyes with good visual potential, keratoplasty is the primary treatment. There are also several other approaches to provide temporary improvement until a permanent solution with keratoplasty can be achieved. These alternatives include hypertonic topical sodium chloride (5%) drops, bandage contact lenses, anterior stromal puncture, phototherapeutic keratectomy, amniotic membrane transplantation, conjunctival flaps, and collagen crosslinking. ...
PURPOSE To investigate whether corneal epithelial cells of individuals with lattice corneal dystrophy (LCD) possess an intrinsic defect. DESIGN Retrospective case-control study. METHODS The medical charts of nine individuals with LCD and those of 14 patients with keratoconus and 11 patients with corneal leukoma (controls), all of whom underwent penetrating keratoplasty (PKP) in one eye at Yamaguchi University Hospital between February 1998 and November 2001, were examined for the time for epithelial resurfacing after surgery. RESULTS The time required for resurfacing of the corneal epithelium after PKP was significantly greater in LCD patients (8.56 +/- 4.95 days, mean +/- SD) than in patients with either keratoconus (1.71 +/- 0.91 days, P = .006) or corneal leukoma (3.00 +/- 1.95 days, P = .03). CONCLUSIONS Corneal epithelial wound healing was delayed in LCD patients after PKP, suggesting that the keratoepithelin gene mutations responsible for this condition affect corneal epithelial cells.

Intrastromal Corneal Ring Segments Combined with Collagen Cross Linking for the Treatment of Keratoconus. A Comparison of...Intrastromal Corneal Ring Segments Combined with Collagen Cross Linking for the Treatment of Keratoconus. A Comparison of...

... significant thinning and intolerance to contact lens wear are indications for corneal transplantation [4]. In the last decade, ... Keratoconus is a corneal ectasia which affects approximately 1 in 200 people [1]. It is characterized by changes in corneal ... 2015) Corneal collagen crosslinking for keratoconus or corneal ectasia without epithelial debridement. Eye (Lond) 29(6): 764- ... After inserting the eyelid speculum, the corneal epithelium over the complete corneal surface was disrupted using the Daya ...
more infohttp://googlescholar.medcraveonline.com/scholars/article_fulltext/3149

Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single...Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single...

All but 2 children experienced stabilization or improvement of corneal clouding. Orthopedic problems have progressed in many ... Results of the cord blood transplantation study (COBLT): outcomes of unrelated donor umbilical cord blood transplantation in ... transplantation, the probability of OS after unrelated donor transplantation was 53%.7,45 In another study of haploidentical ... allowing for early transplantation therapy. Earlier transplantation in patients with IMDs when they have a better performance ...
more infohttp://www.bloodjournal.org/content/112/7/2979.long?sso-checked=true

Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different...Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different...

Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A ... Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A ... Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A ... Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A ...
more infohttps://einstein.pure.elsevier.com/en/publications/evaluation-of-phacoemulsification-induced-oxidative-stress-and-da-2

Corneal transplantation - WikipediaCorneal transplantation - Wikipedia

Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal collagen cross-linking may delay or eliminate the need for corneal transplantation in keratoconus and post-LASIK ... Different types of contact lenses may be used to delay or eliminate the need for corneal transplantation in corneal disorders. ... Corneal transplantation. Cornea transplant approximately one week after surgery. Multiple light reflections indicate folds in ...
more infohttps://en.wikipedia.org/wiki/Keratoplasty

Corneal transplantation, Information about Corneal transplantationCorneal transplantation, Information about Corneal transplantation

In a corneal transplant, a disc of tissue is removed from the center of the eye and replaced by a corresponding disc from a ... Corneal transplant is used when vision is lost in an eye because the cornea has been damaged by disease or traumatic injury. ... Corneal transplant is a very safe procedure that can be performed on almost any patient who would benefit from it. Any active ... In corneal transplant, also known as keratoplasty, a patients damaged corneais replaced by the cornea from the eye of a human ...
more infohttp://www.faqs.org/health/topics/12/Corneal-transplantation.html

OCT in Lamellar Corneal Transplantation | IntechOpenOCT in Lamellar Corneal Transplantation | IntechOpen

... is a valuable tool in corneal transplantation surgery. In deep anterior lamellar keratoplasty (DALK), AS-OCT gives valuable ... B) Corneal thickness map in corneal topography showing corneal edema. (C) Corneal thickness was 753 μm and DSAEK grafts ... B) Preoperative corneal thickness map in corneal topography. (C)preoperative AS-OCT image showing that corneal thickness was ... E) Postoperative corneal thickness map showing resolved corneal edema. (F) AS-OCT image showing that corneal layers were ...
more infohttps://www.intechopen.com/books/oct-applications-in-ophthalmology/oct-in-lamellar-corneal-transplantation

Femtosecond Laser Corneal Transplantation - American Academy of OphthalmologyFemtosecond Laser Corneal Transplantation - American Academy of Ophthalmology

Roger Steinert reviews the use of femtosecond laser for the creation of incisions in corneal transplantation procedures. ... Roger Steinert reviews the use of femtosecond laser for the creation of incisions in corneal transplantation procedures. The ...
more infohttps://www.aao.org/munnerlyn-laser-surgery-center/femtosecond-laser-corneal-transplantation-2

Medical Xpress - corneal transplantationMedical Xpress - corneal transplantation

Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
more infohttps://medicalxpress.com/tags/corneal+transplantation/sort/rank/1w/

Corneal transplantation facts, information, pictures | Encyclopedia.com articles about Corneal transplantationCorneal transplantation facts, information, pictures | Encyclopedia.com articles about Corneal transplantation

Make research projects and school reports about Corneal transplantation easy with credible articles from our FREE, online ... and pictures about Corneal transplantation at Encyclopedia.com. ... "Corneal Transplantation." Merck Manual of Diagnosis and Therapy ... Corneal transplantation. Definition. In corneal transplant, also known as keratoplasty, a patients damaged cornea is replaced ... Corneal Transplantation. Definition. In corneal transplant, also known as keratoplasty, a patients damaged cornea is replaced ...
more infohttps://www.encyclopedia.com/medicine/divisions-diagnostics-and-procedures/medicine/corneal-transplantation

Collaborative Corneal Transplantation Studies (CCTS) - No Study Results Posted - ClinicalTrials.govCollaborative Corneal Transplantation Studies (CCTS) - No Study Results Posted - ClinicalTrials.gov

Collaborative Corneal Transplantation Studies (CCTS). The safety and scientific validity of this study is the responsibility of ...
more infohttps://www.clinicaltrials.gov/ct2/show/results/NCT00000137

Corneal Transplantation - UCLA Health Eye Care - Los Angeles, CACorneal Transplantation - UCLA Health Eye Care - Los Angeles, CA

In corneal transplantation a diseased or scarred cornea is replaced with a healthy one. Special microsurgical instruments are ... Corneal transplantation enjoys a high success rate. The most important factors determining success are the underlying disease ... process and the quality of the tissue used during transplantation. Should the body reject a new cornea, it can be successfully ...
more infohttps://www.uclahealth.org/Eye/corneal-transplantation

Outcome of corneal transplantation | British Journal of OphthalmologyOutcome of corneal transplantation | British Journal of Ophthalmology

Visual function among corneal disease patients waiting for penetrating keratoplasty in British Columbia. Ophthalmic Epidemiol ... a methodology by which they evaluate the visual health state of patients with severe corneal disease requiring transplantation ...
more infohttp://bjo.bmj.com/content/86/1/2

Patient/Donor Blood Type Matching Improves Corneal Transplantation Outcome | National Eye InstitutePatient/Donor Blood Type Matching Improves Corneal Transplantation Outcome | National Eye Institute

Researchers report that donor-recipient tissue typing had nosignificant long-term effect on the success of corneal ... Effectiveness of Histocompatibility Matching in High-Risk Corneal Transplantation. The Collaborative Corneal Transplantation ... Patient/Donor Blood Type Matching Improves Corneal Transplantation Outcome. Archived Page. The information on this page is ... The Collaborative Corneal Transplantation Studies (CCTS) suggestedinstead that matching patient and donor blood types ( ...
more infohttps://www.nei.nih.gov/news/pressreleases/101492

Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation - Full Text View - ClinicalTrials.govTopical Steroid Treatment After Posterior Lamellar Corneal Transplantation - Full Text View - ClinicalTrials.gov

Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation. The safety and scientific validity of this study is ... Investigation of Treatment With Topical Corticosteroid After Posterior Lamellar Corneal Transplantation. Study Start Date :. ... After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. ... Patients treated for primary or secondary corneal endothelial failure at the department of ophthalmology, Aarhus University ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01682421?cond=%22Bullous+Keratopathy%22&intr=%22Hormones%2C+Hormone+Substitutes%2C+and+Hormone+Antagonists%22&rank=2

In corneal transplantation, men and women dont see eye to eye | EurekAlert! Science NewsIn corneal transplantation, men and women don't see eye to eye | EurekAlert! Science News

The findings, which are published in the American Journal of Transplantation, suggest that gender matching may be beneficial to ... potentially reduce the risk of failure and rejection in patients undergoing corneal transplantation. ... A study of patients undergoing corneal transplants indicates that subtle differences between men and women may lead to poorer ... In corneal transplantation, men and women dont see eye to eye. Wiley ...
more infohttps://www.eurekalert.org/pub_releases/2016-07/w-ict071216.php

Stem Cell Breakthrough in the Eyes Can Replace Corneal Transplantation in FutureStem Cell Breakthrough in the Eyes Can Replace Corneal Transplantation in Future

Will this cure revolutionize treatment for corneal blindness in the world? Indo-American duo is trying to unveil a major ... Can stem cell cure replace corneal transplantation in the future? ... One such application is the eye is to treat corneal blindness that currently requires corneal transplantation. 3. Could you ... Can stem cell cure replace corneal transplantation in the future? Will this cure revolutionize the treatment for corneal ...
more infohttps://www.medindia.net/news/healthinfocus/stem-cell-breakthrough-in-the-eyes-can-replace-corneal-transplantation-in-future-145481-1.htm

Corneal Transplantation - procedure, recovery, blood, removal, complications, adults, time, infectionCorneal Transplantation - procedure, recovery, blood, removal, complications, adults, time, infection

Corneal transplants are performed by an ophthalmologist, who is a corneal specialist and is expert at transplants and corneal ... I had corneal transplantation surgery 3 weeks ago in China. Very good results so far, the surgeon asked me to stay in the ... Corneal Surgery. St. Louis: Mosby, 1993. Bruner, William E., Walter J. Stark, and A. Edward Maumenee. Manual of Corneal Surgery ... I have corneal scaring in my eye.When I was much younger, I used contacs and I got a corneal ulcer and got treatment and it ...
more infohttps://www.surgeryencyclopedia.com/Ce-Fi/Corneal-Transplantation.html

Corneal Transplantation | Ocular Health St Louis - Barnes-Jewish HospitalCorneal Transplantation | Ocular Health St Louis - Barnes-Jewish Hospital

It can also be referred to as a corneal transplant, keratoplasty, penetrating keratoplasty (PK) or corneal graft. Barnes-Jewish ... Hospital offers two types of corneal transplants - a deep anterior lamellar keratoplasty (DALK) and a Descemets stripping ... CORNEAL TRANSPLANTATION A corneal transplantation is a procedure which replaces damaged tissue on the eyes clear surface. It ... In addition to conventional corneal transplantation using a full-thickness corneal button to replace the damaged or scarred by ...
more infohttps://www.barnesjewish.org/Medical-Services/Ophthalmology/Corneal-Transplantation

Corneal transplantation - WikipediaCorneal transplantation - Wikipedia

Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal collagen cross-linking may delay or eliminate the need for corneal transplantation in keratoconus and post-LASIK ... Different types of contact lenses may be used to delay or eliminate the need for corneal transplantation in corneal disorders. ... However, in most of the cases where corneal transplantation is recommended, PTK would not be effective. In corneal disorders ...
more infohttps://en.wikipedia.org/wiki/Corneal_transplantation

Corneal TransplantationCorneal Transplantation

... is an outpatient procedure utilizing corneal tissue from a cadaver. The graft can be either partial ( ... Transplantation is usually indicated after visual loss from corneal cloudiness or distortion in shape secondary to disease and/ ... Corneal transplantation allows the implementation of various anesthetic techniques because of the superficial nature of the ... Link Between Liver Steatosis and New-Onset Diabetes After Transplantation. *Islet Cell Transplantation After Pancreatic ...
more infohttps://www.endocrinologyadvisor.com/anesthesiology/corneal-transplantation/article/581637/

Quality of Life Assessment After Corneal Transplantation  | IOVS | ARVO JournalsQuality of Life Assessment After Corneal Transplantation | IOVS | ARVO Journals

Quality of Life Assessment After Corneal Transplantation F Mendes; DA Schaumberg; S Navon; R Steinert; J Sugar; E Holland; MR ... Quality of Life Assessment After Corneal Transplantation You will receive an email whenever this article is corrected, updated ... The main indications for surgery were: bullous keratopathy (32%), corneal scarring (18%), keratoconus (17%), corneal dystrophy ... Quality of Life Assessment After Corneal Transplantation . Invest. Ophthalmol. Vis. Sci. 2002;43(13):3069. ...
more infohttp://iovs.arvojournals.org/article.aspx?articleid=2420312

Corneal transplantation | definition of corneal transplantation by Medical dictionaryCorneal transplantation | definition of corneal transplantation by Medical dictionary

What is corneal transplantation? Meaning of corneal transplantation medical term. What does corneal transplantation mean? ... Looking for online definition of corneal transplantation in the Medical Dictionary? corneal transplantation explanation free. ... corneal transplantation transplantation of a donor cornea into the eye of a recipient; see also corneal transplantation. ... Related to corneal transplantation: Penetrating keratoplasty. Corneal Transplantation. Definition. In corneal transplant, also ...
more infohttp://medical-dictionary.thefreedictionary.com/corneal+transplantation

Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation - Full Text View -...Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation - Full Text View -...

Piggyback Sulcoflex Toric IOL for Correcting Refractive Error Following Corneal Transplantation. The safety and scientific ... Refractive Error Corneal Implantation Intraocular Lens Implantation Procedure: toric intraocular lens implantation Procedure: ... sulcoflex toric intraocular lens in pseudophakic patients for correcting refractive errors following corneal transplantation ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01718184?recr=Open&cond=%22Lenses%2C+Intraocular%22&rank=8

Live Imaging of Lymphatic Valve Formation after Corneal Transplantation | IOVS | ARVO JournalsLive Imaging of Lymphatic Valve Formation after Corneal Transplantation | IOVS | ARVO Journals

Methods: Standard orthotopic corneal transplantation was performed with Prox1-GFP mice as recipients. Corneal grafts of the ... Results: Prox-1 positive lymphatic vessels and valves were formed after corneal transplantation. As corneal lymphangiogenesis ... Live Imaging of Lymphatic Valve Formation after Corneal Transplantation Gyeong Jin Kang; Tatiana Ecoiffier; Young-Kwon Hong; Lu ... Live Imaging of Lymphatic Valve Formation after Corneal Transplantation You will receive an email whenever this article is ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2146765
  • But about one in 10 patients receiving a cornealtransplant is at high risk of rejecting the donor tissue, or graft,because: (1) they have previously rejected a corneal transplant, or(2) new blood vessels have grown into their damaged cornea,introducing immune cells into this normally avascular region of theeye that may later recognize the graft as foreign and attack it. (nih.gov)
  • In rheumatology, oncology, transplantation medicine and ophthalmology, therapeutic antibody constructs, and antibody fragments have been responsible for the clinical progress seen over the last decade. (uzh.ch)
  • All corneal transplantations were performed in the Department of Ophthalmology, Shenyang General Hospital of PLA. (hindawi.com)
  • In fact most corneal transplantations in our country are performed for this reason. (medindia.net)
  • The CCTS has produced some excellent data onhigh-risk corneal transplantation," said Louis W. Sullivan, M.D.,secretary of Health and Human Services. (nih.gov)
  • Corneal epithelial abnormalities in the foreign group were significantly higher than that in domestic group. (hindawi.com)
  • Pre-sensitized animals that received third-party allo-MSC prior to transplantation had significantly higher proportions of CD45 + CD11b + B220 + monocytes in the lungs 24 h after the second MSC injection and significantly higher proportions of CD4 + FoxP3 + regulatory T cells in the graft-draining lymph nodes at the average day of rejection of control animals. (frontiersin.org)
  • Will this cure revolutionize the treatment for corneal blindness in the world? (medindia.net)
  • One such application is the eye is to treat corneal blindness that currently requires corneal transplantation. (medindia.net)
  • Corneal scarring is a major cause of blindness in India. (medindia.net)
  • This huge gap in supply and demand leads to further increase in the backlog and burden of corneal blindness. (medindia.net)
  • Although antibody-based therapies have become a well-established immunosuppressive option in solid organ transplantation, there are only very few reports with regard to corneal transplantation. (uzh.ch)
  • This presentation by Dr. Roger Steinert reviews the use of femtosecond laser for the creation of incisions in corneal transplantation procedures. (aao.org)
  • Although the cornea is not normally vascular, some corneal diseases cause vascularization (the growth of blood vessels) into the cornea. (faqs.org)
  • In some diseases, only the inside layer (endothelium) is affected, causing corneal oedema (swelling) and clouding (see below). (moorfields.ae)
  • Conclusions The innate immune response to allogeneic corneal tissue is more vigorous in the presence of allergic conjunctivitis than in naive eyes and is associated with accelerated lymphatic ingrowth to host cornea. (bmj.com)
  • After corneal transplantation in BALB/c mice, we analyzed T-cell infiltration in the cornea and the draining lymph nodes using flow cytometry. (sigmaaldrich.com)
  • We conducted several tests to verify that these cells were, in fact, corneal stem cells. (medindia.net)
  • Therapeutic: To remove inflamed corneal tissue unresponsive to treatment by antibiotics or anti-virals. (wikipedia.org)
  • The following review explains some of the important aspects of engineered antibody-based therapeutic agents and summarises the current use of such immunosuppressive therapies in transplantation medicine and corneal transplantation. (uzh.ch)