Corneal Perforation
Corneal Ulcer
Eye Infections, Bacterial
Eye Infections, Fungal
Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.
Keratoplasty, Penetrating
Rupture, Spontaneous
Cornea
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Esophageal Perforation
Eye Infections
Tissue Adhesives
Tympanic Membrane Perforation
Uterine Perforation
Peptic Ulcer Perforation
Visual Acuity
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Pseudomonas aeruginosa
Pneumoperitoneum
Meibomian Glands
Enhancing effects of sericin on corneal wound healing in Otsuka Long-Evans Tokushima fatty rats as a model of human type 2 diabetes. (1/15)
The protein sericin is the main constituent of silk. We investigated the effects of sericin on corneal wound healing in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model for human type 2 diabetes. Corneal wounds were prepared by removal of the corneal epithelium, and documented using a TRC-50X equipped with a digital camera. Sericin solutions were instilled into the eyes of rats five times a day following corneal abrasion. Plasma glucose and triglycerides were determined using an Accutrend GCT. Cholesterol and insulin were measured using a Cholesterol E-Test Kit and ELISA Insulin Kit, respectively. The plasma levels of glucose, triglycerides, cholesterol and insulin in 38-week-old OLETF rats were significantly higher than in Long-Evans Tokushima Otsuka (LETO) rats used as normal controls, and the rate of corneal wound healing in OLETF rats was slower than in LETO rats. The corneal wounds of rats instilled with saline showed almost complete healing by 72 h after corneal epithelial abrasion. On the other hand, the corneal healing rate of OLETF rats instilled with 10% sericin solution was significantly higher than that of LETO rats instilled with saline, and the wounds showed almost complete healing at 48 h after abrasion. The corneal healing rate increased with increasing sericin concentration. The present study demonstrates that the corneal wound healing rate in OLETF rat is slower than in LETO rats, and the instillation of sericin solution has a potent effect in promoting wound healing and wound-size reduction in LETO and OLETF rats. (+info)Corneal perforation with preseptal cellulitis in a patient with acute lymphocytic leukemia. (2/15)
(+info)One cornea for two patients: case report. (3/15)
(+info)Four cases of corneal perforation in patients with chronic graft-versus-host disease. (4/15)
PURPOSE: To report the clinical features and investigate the underlying pathological processes of spontaneous corneal perforation in patients with ocular chronic graft-versus-host disease (cGVHD). METHODS: A full ophthalmological evaluation of corneal perforation in four patients with cGVHD was performed. Three of them underwent deep anterior lamellar keratoplasty and samples from two of three patients were used for histopathological analyses. RESULTS: Three patients were successfully treated by corneal transplantation. One patient was treated with a therapeutic soft contact lens, and the wound healed within 2 days. The common clinical features of these patients were (1) the presence of definite dry eye related to cGVHD in 3 of 4 patients and probable dry eye in one patient, (2) a central or paracentral site of corneal ulceration and perforation, with no sign of infection, and (3) prior use of a topical or systemic corticosteroid, and/or topical non-steroidal anti-inflammatory drugs. Immunohistochemical findings revealed an increased number of cluster of differentiation 68(+) (CD68(+)) macrophages and matrix metalloproteinase 9 (MMP-9) expression in the tissue surrounding the perforation. CONCLUSIONS: Our report extends current information on the clinical features and pathological processes of corneal perforation in cGVHD by showing increased MMP-9 expression and the accumulation of CD68(+) positive macrophages in the affected areas. (+info)Tectonic deep anterior lamellar keratoplasty in impending corneal perforation using cryopreserved cornea. (5/15)
(+info)VIP and growth factors in the infected cornea. (6/15)
(+info)Synthetic fiber from a teddy bear causing keratitis and conjunctival granuloma: case report. (7/15)
(+info)Superimposed fungal ulcer after fibrin glue sealant in infectious corneal ulcer. (8/15)
(+info)
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Corneal perforation
... is an anomaly in the cornea resulting from damage to the corneal surface. A corneal perforation means that ... Non infected corneal perforation generally heals when a pressure bandage is used. For certain types of corneal perforations, ... Damage to the cornea due to corneal perforation can cause decreased visual acuity. Corneal perforation may cause difficulty in ... Pellucid marginal degeneration may cause corneal thinning, leading to perforation. Corneal perforation can be diagnosed by ...
Phosgene oxime
More severe exposures can result in keratitis, iritis, corneal perforation, and blindness. Respiratory: Irritation of the ...
Herpes zoster ophthalmicus
Neurotrophic: corneal nerve damage causes a persistent epithelial defect, thinning and even perforation. The cornea becomes ... Uncommon Necrotising interstitial keratitis: Characterised by stromal infiltrates, corneal thinning and possibly perforation. ... "Herpetic Corneal Infections: Herpes Zoster Ophthalmicus". www.aao.org. Retrieved 21 December 2019. "Herpes Zoster Ophthalmicus ... Disciform Keratitis (Disciform Endotheliitis): a disc of corneal oedema, folds in Descemet's membrane, mild inflammation ...
Neisseria gonorrhoeae
The eye infection can lead to corneal scarring or perforation, ultimately resulting in blindness. If the newborn is exposed ...
Acanthamoeba keratitis
In cases of corneal ulceration or perforation, or if corneal scarring is severe, corneal transplant may be required. This ... Corneal ulceration, or in severe cases, perforation, can also occur and may be accompanied by hypopyon. In cases of keratitis, ... Soft contact lenses are more adherent to the corneal surface than hard lenses, which allows the Acanthamoeba organism to bind ... AK should be considered in all patients who use contact lenses, and following corneal abrasions or trauma. A thorough history ...
Pellucid marginal degeneration
PMD lacks apical corneal scarring, Rizutti's phenomenon, Munson's sign, and the central corneal thickness is usually normal. ... Rarely, it may cause acute vision loss with severe pain due to perforation of the cornea. It is typically characterized by a ... Intacs implants, corneal collagen cross-linking, and corneal transplant surgery are additional options. Surgery is reserved for ... The gold standard diagnostic test for PMD is corneal topography. However, it may not be as specific as corneal pachymetry, ...
Pemphigoid
Besides, reduced tearing with erosion and neovascularization of the cornea leads to corneal opacification and perforation. ...
Corneal ulcer
This type of ulcer is especially dangerous and can rapidly result in corneal perforation, if not treated in time. The location ... Deep ulcers extend into or through the stroma and can result in severe scarring and corneal perforation. Descemetoceles occur ... In ophthalmology, a corneal ulcer usually refers to having an infectious cause while the term corneal abrasion refers more to ... Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ...
Erlotinib
Serious side effects may include lung problems, kidney problems, liver failure, gastrointestinal perforation, stroke, and ... Stevens-Johnson syndrome/toxic epidermal necrolysis ocular disorders corneal lesions Pulmonary toxicity interstitial ... ingrown hairs, such as eyelashes gastrointestinal tract toxicity serious or fatal gastrointestinal tract perforations skin ... corneal ulceration. Use in pregnancy may harm the baby. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal ...
Peripheral ulcerative keratitis
Grade I refers to corneal thinning, grade II describes impending corneal perforation, and grade III is corneal perforation with ... Corneal transplantation is a management option when there is severe corneal melting or perforation although one possible ... corneal perforation and increased risk of recurrence. PUK is a rare condition with an estimated incidence of 3 per million ... The corneal epithelium consists of five to six layers of cells with a total thickness of around 0.52mm. The cornea thickens to ...
Corneal pachymetry
By using the corneal pachymetry the surgeon will reduce the chances of perforation of the eye and improves surgical outcome. ... Corneal pachymetry is essential for other corneal surgeries such as Limbal Relaxing Incisions. LRI is used to reduce corneal ... think of it as a corneal A-scan. Pachymetry using the corneal waveform allows the user to more accurately measure the corneal ... Pachymetry using the corneal waveform process allows the user to more accurately measure the corneal thickness, verify the ...
Topical prednisolone
... corneal and scleral thinning is also one of its consequences. When not ceased, thinning may ultimately lead to perforation of ... Corneal thinning: When corticosteroids are used in the long term, ... corneal injuries caused by chemicals, radiations and thermal burns, or penetration of foreign objects. It is also used in the ... such as corneal injuries caused by chemicals, burns and alien objects, inflammation of the eyes, mild to moderate non- ...
Exposure keratopathy
If corneal ulcer is detected, it may be treated medically with antibiotics. If corneal perforation has occurred, immediate ... It can lead to corneal ulceration and permanent loss of vision due to corneal opacity. Normally, corneal surface is kept moist ... This will lead to corneal epithelial damage. Both tear film and corneal epithelium play significant role in corneal protective ... Fluorescein staining may be used to detect for epithelial defects, corneal infection or perforation of the cornea. Tear break- ...
Corneal abrasion
This is because contact lens wearers are often colonized with Pseudomonas aeruginosa, which may cause corneal perforations and ... "Corneal abrasions and corneal foreign bodies: Clinical manifestations and diagnosis". "BestBets: Mydriatics in corneal abrasion ... Fowler GC (2011), "Corneal Abrasions and Removal of Corneal or Conjunctival Foreign Bodies", Pfenninger and Fowler's Procedures ... Ahmed F, House RJ, Feldman BH (September 2015). "Corneal Abrasions and Corneal Foreign Bodies". Primary Care. 42 (3): 363-75. ...
Scleritis
Surgery may be indicated if scleral perforation or excessive scleral thinning is present. Bandage contact lens or corneal glue ... may be used to repair damaged corneal tissue in the eye and preserve the patient's vision. If not treated, scleritis can cause ...
Seidel test
... including corneal post-trauma, post-surgical leak, corneal perforation and corneal degeneration. Initially the test was used to ... If the fluorescein strip turns pale upon application to the corneal surface, the person tests positive for the corneal ... Any changes in color or surface of the fluorescence area indicate the presence of corneal leakage. The test is contraindicated ... Leakage may occur due to many corneal or scleral disorders, ...
Fungal keratitis
Corneal perforation can occur in patients with untreated or partially treated infectious keratitis and requires surgical ... It is a dry looking corneal ulcer with satellite lesions in the surrounding cornea. Usually associated with fungal ulcer is ... from the corneal scraping. Recent advances have been made in PCR ref 3./immunologic tests which can give a much quicker result ... intervention in the form of corneal transplantation. This disease is quite common in the tropics and with large agrarian ...
Corneal opacity
... results when healing occurs after perforation of cornea with incarceration of iris. The iris is adherent to the back of a ... The term corneal blindness is commonly used to describe blindness due to corneal opacity. Depending on the density, corneal ... Corneal transplantation Corneal ulcer Corneal button "WHO -Priority eye diseases". www.who.int. Archived from the original on ... Femtosecond laser-assisted corneal tattooing: Femtosecond laser-assisted corneal tattooing is a new corneal tattooing technique ...
Bromfenac
Serious side effects such as corneal perforation were not reported in studies but only during post-marketing in less than one ...
Mon Mon Mon Monsters
Lin is then restrained by the neck with an animal control pole, threatened by Renhao with corneal perforation from a wall dart ...
Blast-related ocular trauma
Application of the Seidel Test in Zone I will rule out seepage of the anterior chamber through a corneal perforation, while ... thereby determining the presence of corneal perforation and pathological anterior chamber leakage. Zone II: region designated ... Globe perforation, oculoplastic intervention, and neuro-ophthalmic injuries contribute significantly to reported poor visual ... the conjunctiva and corneal surface; the most common injuries seen in this zone are foreign debris retention by the conjunctiva ...
Corneal transplantation
... after corneal perforation. Therapeutic: To remove inflamed corneal tissue unresponsive to treatment by antibiotics or anti- ... Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... In corneal disorders where vision correction is not possible by using contact lenses, intrastromal corneal ring segments may be ... Corneal collagen cross-linking may delay or eliminate the need for corneal transplantation in keratoconus and post-LASIK ...
Neurotrophic keratitis
... spontaneous corneal epithelium breakdown, poor corneal healing and development of corneal ulceration, melting and perforation. ... In the most severe forms (stage III), it is necessary to stop the progression towards corneal perforation: in these cases, a ... Corneal contact lenses can also be used in this stage of the disease, for their protective action to improve corneal healing. ... Corneal sensitivity test: performed by placing a cotton wad or cotton thread in contact with the corneal surface: this only ...
Perforation (disambiguation)
Corneal perforation Eardrum perforation Esophageal perforation Gastrointestinal perforation Nasal septum perforation Stercoral ... A perforation is a small hole in a thin material or web. Perforation may also refer to: A leaf feature Perforation (oil well), ... perforation Uterine perforation This disambiguation page lists articles associated with the title Perforation. If an internal ... a term used in philately Postage stamp perforation, used to separate postage stamps Film perforations, the holes placed in the ...
Corneal ulcers in animals
Deep ulcers extend into or through the stroma and can result in severe scarring and corneal perforation. Descemetoceles occur ... Other eye conditions can cause corneal ulcers, such as entropion, distichiae, corneal dystrophy, and keratoconjunctivitis sicca ... or corneal transplant. Topical corticosteroids and anesthetics should not be used on any type of corneal ulcer because they ... as disruption of the corneal epithelium allows attachment and colonisation of the underlying tissues by normal corneal ...
Keratoglobus
... for corneal ectasias involving corneal periphery". Br J Ophthalmol. 92 (2): 286-290. doi:10.1136/bjo.2007.124628. PMID 18227208 ... The patient is at risk for globe perforation because the thinned out cornea is extremely weak. It is a much rarer condition ... It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye. It is sometimes equated ... Further progression of the disease usually leads to a need for corneal transplantation because of extreme thinning of the ...
Dry eye syndrome
... corneal neovascularization, corneal scarring, corneal thinning, and even corneal perforation. Another contributing factor may ... Some severe cases result in thickening of the corneal surface, corneal erosion, punctate keratopathy, epithelial defects, ... in which the corneal nerves which stimulate tear secretion are cut during the creation of a corneal flap. Dry eye caused by ... Tear osmolarity may be a more sensitive method of diagnosing and grading the severity of dry eye compared to corneal and ...
Keratitis
Others may result in perforation of the cornea, endophthalmitis (an infection inside the eye), or even loss of the eye. With ... Facts About the Cornea and Corneal Disease The National Eye Institute (NEI) Filimentary keratitis (Webarchive template wayback ... Acanthamoebic keratitis Amoebic infection of the cornea is a serious corneal infection, often affecting contact lens wearers. ... A Pseudomonas Protease Capable of Mediating Corneal Erosions". Invest Ophthalmol Vis Sci. 50 (8): 3794-801. doi:10.1167/iovs.08 ...
Arachidonate 5-lipoxygenase
In a model of cecum perforation-induced sepsis, ALOX5 gene knockout mice exhibited a decrease in the number of neutrophils and ... and corneal injury. These studies indicate that Alox5 can serve a protective function presumably by generating metabolites such ...
Trepanning
The intentional perforation of the cranium exposes the dura mater to treat health problems related to intracranial diseases or ... In modern eye surgery, a trephine instrument is used in corneal transplant surgery. The procedure of drilling a hole through a ... The perforations were found with the growth of fine bone spurs, which indicate that trepanation had been carried out on live ...
Trilobite
Lenses were hexagonally close packed, touching each other, with a single corneal membrane covering all lenses. Each lens was in ... ridging and perforations. The exact purpose of the prosopon is not resolved but suggestions include structural strengthening, ...
List of ICD-9 codes 320-389: diseases of the nervous system and sense organs
... cornea 371.0 Corneal scars and opacities 371.1 Corneal pigmentations and deposits 371.2 Corneal oedema 371.3 Changes of corneal ... Acute myringitis without mention of otitis media 384.1 Chronic myringitis without mention of otitis media 384.2 Perforation of ... membranes 371.4 Corneal degenerations 371.5 Hereditary corneal dystrophies 371.6 Keratoconus 371.7 Other corneal deformities ... Interstitial and deep keratitis 370.6 Corneal neovascularization 370.8 Other forms of keratitis 370.9 Unspecified 371 Corneal ...
Amatoxin
Contact with the eyes may result in irritation, corneal burns, and eye damage. Persons with pre-existing skin, eye, or central ... At the molecular level, amatoxins cause damage to cells of these organs by causing perforations in the plasma membranes ...
Intraocular pressure
This is significant for example if the patient requires anaesthesia for a trauma and has sustained an eye (globe) perforation. ... Grieshaber MC, Schoetzau A, Zawinka C, Flammer J, Orgul S (June 2007). "Effect of central corneal thickness on dynamic contour ... A newer transpalpebral and transscleral tonometry method is not influenced by corneal biomechanics and does not need to be ... Measured values of intraocular pressure are influenced by corneal thickness and rigidity. As a result, some forms of refractive ...
Sclera
The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations ... as opposed to the near-uniform thickness and parallel arrangement of the corneal collagen. Moreover, the cornea bears more ...
Robot-assisted surgery
... uses telemanipulation to perform pterygium repairs and ex-vivo corneal surgeries. Some examples of heart surgery being assisted ... "Computer-enhanced robotic telesurgery minimizes esophageal perforation during Heller myotomy". Surgery. 138 (4): 553-558, ...
Globe rupture
Open-globe injuries (also called globe rupture, globe laceration, globe penetration, or globe perforation) are full-thickness ... Visible corneal or scleral laceration Sub-conjunctival hemorrhage Protruding foreign bodies Vitreous fluid leakage Changes in ...
Anesthesia for eye surgery
One drop of xylocaine instilled four times after every 4 minutes will produce conjunctival and corneal anaesthesia. Paracaine, ... The complications of retrobulbar block are globe perforation, optic nerve injury, retrobulbar haemorrhage and extraocular ...
Ehlers-Danlos syndromes
... risk of colonic perforation exists. Pregnancy increases the likelihood of uterine rupture. Maternal mortality is around 12%. ... corneal scarring, brittle cornea syndrome, cataracts, carotid-cavernous sinus fistulas, macular degeneration Craniocervical ...
CORNEAL PERFORATION - Veterinary Ophthalmic Consulting
Corneal Higher-Order Aberrations in Eyes with Corneal Scar after Traumatic Perforation - Fingerprint - Keio University
IMSEAR at SEARO: Sterile corneal perforation after cataract surgery in keratoconus posticus circumscriptus.
Trabeculectomy: Overview, Indications, Contraindications
However, corneal perforation is a possibility. To place a corneal traction suture, a 7-0 or 8-0 nonslippery suture (eg, silk or ... Use high magnification when placing the corneal bridle suture. This reduces the likelihood of corneal penetration or creating a ... The potential complications of this injection are severe corneal epithelial toxicity and early or late bleb leak. The corneal ... A corneal traction suture does not puncture the conjunctiva, can be placed at various locations and can pull the eye in ...
A hyperdry amniotic membrane patch using a tissue adhesive for corneal perforations and bleb leaks. | Am J Ophthalmol;148(3):...
Five eyes of 5 patients (glaucoma bleb leaks, 2 eyes; corneal perforations, 3 eyes) were treated with a single-layer patch of ... There were no remarkable adverse effects, and there was no recurrence of bleb leak or corneal perforation. CONCLUSIONS:. The ... To evaluate the efficacy of hyperdry amniotic membrane (AM) patching attached using a tissue adhesive for corneal perforations ... A hyperdry amniotic membrane patch using a tissue adhesive for corneal perforations and bleb leaks.. Kitagawa, Kiyotaka; ...
Laser in situ Keratomileusis (LASIK) - American Academy of Ophthalmology
Corneal Perforation. Corneal perforation is a rare but devastating intraoperative complication that can occur if the ... Corneal perforation also can occur with LASIK on an excessively thin cornea. Corneal thickness must be measured with pachymetry ... Measuring corneal thickness using pachymetry is important before LASIK, because to avoid corneal ectasia, an adequate stromal ... Second, use of a cryolathe to freeze the corneal cap for precise lenticular reshaping of corneal tissue. The cryolathe was ...
Double small incision lenticule extraction lenticular graft in impending corneal perforation Kotb AN, Elsayed SH - Delta J...
Figure 1 Case of impending corneal perforation.. Click here to view. Confirmation of impending corneal perforation was carried ... and possible perforation. Resistant corneal ulcers and impending corneal perforation are usually with poor prognosis, including ... Surgical success was defined as healing of the corneal ulcer or perforation and the survival of the corneal graft.. Figure 5 ... Impending corneal perforation is an urgent condition caused by different types of infectious and noninfectious corneal ...
Vitamin A Deficiency: Practice Essentials, Background, Pathophysiology
OBM Transplantation | Bilateral Corneal Perforation in a Patient with Chronic Ocular Graft-Versus-Host Disease: A Case Report...
Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. We reported the case of a 65-year-old male ... Therefore, corneal perforation can occur as the presenting manifestation of ocular GVHD. Regular ophthalmological examinations ... and lacrimal punctal occlusion surgery resulted in the successful resolution of the corneal perforation with satisfactory ... patient who developed corneal perforation sequentially in both eyes 3 years after receiving HSCT. Conservative treatment with ...
Real-Time PCR for Diagnosis of Oculoglandular Tularemia - Volume 16, Number 1-January 2010 - Emerging Infectious Diseases...
Blister Agents: Sulfur Mustard Agent H/HD, Sulfur Mustard Agent HT | Medical Management Guidelines | Toxic Substance Portal |...
High concentrations of vapor or liquid can cause corneal edema, perforation, blindness, and later scarring. ... Erosion of or perforation of the cornea may occur with very severe exposure to liquid, but this is rare. Readily available eye ... Marked lid edema, possible corneal damage, severe pain. 1-2 hours. Airways - mild. Rhinorrhea, sneezing, epistaxis, hoarseness ... However, the risk of potential bleeding and perforation must be considered. There is no evidence that activated charcoal is ...
Adult Blepharitis: Background, Pathophysiology, Epidemiology
If severe inflammation develops, corneal perforation can occur.. Race. No known studies demonstrate racial differences in the ... Artificial Intelligence and Corneal Diseases * Recurrent Squamous Cell Carcinoma and a Novel Mutation in a Patient With ... Corneal damage can result in inflammation, scarring, loss of surface smoothness, irregular astigmatism, and loss of optical ...
2013 ICD-9-CM Diagnosis Code 370.00 : Corneal ulcer, unspecified
These highlights do not include all the information needed to use
VECTIBIX
safely and effectively. See full...
... and corneal perforation have occurred with Vectibix use. Monitor for evidence of keratitis, ulcerative keratitis, or corneal ... or corneal perforation. Interrupt or discontinue Vectibix for acute or worsening keratitis, ulcerative keratitis, or corneal ... Eye disorders: Keratitis/ulcerative keratitis, corneal perforation [see Warnings and Precautions (5.8)] ... Interrupt or discontinue Vectibix therapy for acute or worsening keratitis, ulcerative keratitis, or corneal perforation. ...
Bacitracin (EENT) Monograph for Professionals - Drugs.com
Use in patients with thin corneal and scleral tissue may result in perforation. ... In vitro staining and/or cultures of corneal material are indicated in management of keratitis involving corneal infiltrates ... Corneal and scleral thinning reported with various ocular diseases and with long-term use of topical ophthalmic corticosteroids ... Because bacterial keratitis may be associated with subsequent loss of vision as the result of corneal scarring or topographic ...
Iressa (gefitinib) dosing, indications, interactions, adverse effects, and more
Details - Public Health Image Library(PHIL)
A new surgical technique for deep stromal, anterior lamellar keratoplasty | British Journal of Ophthalmology
... the posterior corneal lamella was separated from the overlying anterior stroma, to avoid perforation of the posterior corneal ... Corneal dissection depth averaged 95.4% (SD 2.7%). Six patient eyes had uneventful surgeries; in a seventh eye, perforation of ... 1994) Lamellar keratoplasty in the management of inflammatory corneal ulceration and perforation. Eye 8:22-28. ... the non-incised corneal tissue between the tip of the blade and the posterior corneal surface is visible as a dark band ...
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One patient experienced ulcerative keratitis with perforation requiring corneal transplantation. Cases of symblepharon were ... TIVDAK caused changes in the corneal epithelium and conjunctiva resulting in changes in vision, including severe vision loss, ... and corneal ulceration. Conduct an ophthalmic exam at baseline, prior to each dose, and as clinically indicated. Adhere to ... The most common were conjunctival adverse reactions (40%), dry eye (29%), corneal adverse reactions (21%), and blepharitis (8 ...
Trauma (penetrating) - College of Optometrists
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Draft Recommendation Statement: Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Preventive Medication | United States...
1-3 Gonococcal ophthalmia neonatorum can cause corneal scarring, ocular perforation, and blindness as early as 24 hours after ... Untreated gonococcal ophthalmia neonatorum can result in severe and lasting conditions, including corneal scarring, ocular ... resulting in corneal damage in 20% and blindness in 3% of infected infants.14,15 An observational study from Nairobi, Kenya in ... perforation, and blindness.6 There are no contemporary estimates of blindness related to gonococcal ophthalmia neonatorum in ...
KeratitisCorneaUlcerOcularTransplantationPenetrating keratoplastyManagement of impendiUlcersEpitheliumConjunctivalVisual AcuityStromalScleralGraftTissueDefectsLacerationSTROMAUveitisEdemaSevereComplicationsOphthalmicKeratoconusSurgicalIncisionSlit-lampEyelidInfiltrationScrapingsOpacificationKeratopathyLamellarCongenitalTraumaDiseasesPosteriorEyesDisordersInflammation
Keratitis14
- Ocular Toxicities: Monitor for keratitis, ulcerative keratitis, or corneal perforation. (nih.gov)
- Interrupt or discontinue Vectibix for acute or worsening keratitis, ulcerative keratitis, or corneal perforation. (nih.gov)
- Because bacterial keratitis may be associated with subsequent loss of vision as the result of corneal scarring or topographic irregularities and because untreated or severe bacterial keratitis may result in corneal perforation with potential for endophthalmitis and possible loss of the eye, optimal management involves rapid evaluation and diagnosis, timely initiation of treatment, and appropriate follow-up. (drugs.com)
- The disease affects the corneal epithelium, causing microbial keratitis, ulceration and perforation. (cdc.gov)
- A study was made of the trend of ophthalmic fungal corneal keratitis in the greater Cairo area of Egypt and its association with climate records during the same period. (who.int)
- In contact lens users, Pseudomonas-induced keratitis can progress rapidly to corneal perforation within 24 hours [2-4] . (cureus.com)
- Neurotrophic keratitis is a rare degenerative eye disease that affects less than five people in every 10,000, which damages the corneal epithelium and also causes a loss of corneal sensitivity. (pharmatimes.com)
- Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: a secondary analysis of the mycotic ulcer treatment trial II. (aravind.org)
- Some of the examples of how the mechanistic understanding of epigenetics can potentially aid drug discovery in eye diseases can be: 1) Latent infection of HSV1 (Herpes Simplex Virus 1) in corneal cells can lead to persistent recurrence of keratitis ( 3 ). (frontiersin.org)
- Eyelid retraction can lead to lagophthalmos and exposure keratitis, which can cause mild ocular surface irritation to vision-threatening corneal decompensation. (eyewiki.org)
- Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs. (qxmd.com)
- Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis, with subconjunctival antibiotics used only under unusual circumstances, and systemic antibiotics used only in cases of perforation or specific organisms (eg, N gonorrhoeae ). (medscape.com)
- Infectious keratitis was defined by the presence of corneal infiltration along with an overlying epithelial defect. (entokey.com)
- Both of them showed development of keratitis during the management with corticosteroids, delayed onset, slow response to antibiotics, and relatively less affected corneal epithelium. (ekjo.org)
Cornea12
- Leaving a narrow hinge of tissue allowed the outer cornea to become a flap that is reflected out of the way during the laser exposure, then returned to its original position and allowed to adhere through natural corneal dehydration to the underlying stromal bed (Figure 1). (aao.org)
- Various clinical conditions - such as viral infections of the cornea, eye injuries, chemical burns and lesions, corneal surgery, or systemic illnesses such as diabetes - can cause the disease, but as yet there is no direct treatment of the nerve impairment that constitutes its main cause. (pharmatimes.com)
- Alkali burns of the cornea frequently lead to persistent epithelial defects which result in ulceration and perforation. (uveitis.org)
- A corneal transplant is a surgical procedure that involves replacing the cloudy/scarred cornea with a donor cornea to restore vision. (singhealth.com.sg)
- Most individuals with poor vision due to a diseased or cloudy cornea, whose nerve and retina at the back of the eye is still healthy, may benefit from a corneal transplant to see well. (singhealth.com.sg)
- A cloudy or opaque cornea can occur from scarring of any cause (e.g., injuries or infections) or cloudy swelling of the cornea due to damage or ageing of the innermost layer of cells of the cornea (known as the corneal endothelial layer). (singhealth.com.sg)
- Less commonly, corneal transplants can be done on an urgent basis to treat severe Corneal Infections, or to repair or 'patch up' severe thinning, defects or perforations in the cornea or sclera (the sclera is the white coating of the eye). (singhealth.com.sg)
- PetsEyes BioCorneaVet will be permanently resided in the recipient's cornea and gradually become a part of corneal stroma after the remodeling process 1-6 months after the keratoplasty with less immunological response and vision/cosmetic restoration. (petseyes.cn)
- PetsEyes BioCorneaVet is a trustable decellularized/bioengineered porcine-sourced cornea in the treament of various corneal diseases in veterinary ophthalmology. (petseyes.cn)
- Keratoplasty is a surgical procedure to replace all or part of the cornea with donated corneal tissue. (cvpdaytoneyedoctors.com)
- At CVP Physicians Dayton, our fellowship-trained corneal specialists Dr. Adam Cloud, Dr. David Denlinger and Dr. Jennifer Shade have extensive experience in performing cornea transplants. (cvpdaytoneyedoctors.com)
- There are several types of corneal transplant surgery, which vary based on the technique used and the amount of the cornea which is removed. (cvpdaytoneyedoctors.com)
Ulcer8
- Short description: Corneal ulcer NOS. (icd9data.com)
- The Utility of Repeat Culture in Fungal Corneal Ulcer Management: a secondary analysis of the MUTT I randomized clinical trial group. (aravind.org)
- She presents to your clinic with a 1-week history of pain and redness in the left eye, reduced vision, and an apparent corneal ulcer. (mrcophth.com)
- My answer plan was:I defined my problem as a corneal ulcer that may be related to the proptosis (Exposure) I excluded serious condition of infection. (mrcophth.com)
- One randomized trial of 500 patients with bacterial corneal ulcer who received the fluoroquinolone moxifloxacin found a higher resistance to the agent was associated with worse clinical outcomes. (medscape.com)
- Among these threats, a relatively common occurrence is the corneal ulcer-of which there are several types. (reviewofoptometry.com)
- This patient's corneal ulcer could have any of a number of causes. (reviewofoptometry.com)
- Corneal cultures can help identify the specific type of corneal ulcer you're dealing with in each case and help you tailor treatment accordingly. (reviewofoptometry.com)
Ocular10
- Corneal perforation as a result of trauma, severe, rapidly progressive corneal ulceration or a ruptured desmetocele constitutes an ocular emergency. (veterinaryophthalmicconsulting.com)
- The hyperdry AM is a useful substrate, and this surgical procedure is a promising method to treat glaucoma filtering bleb leak or corneal perforation , which may result in serious vision -threatening ocular complications . (bvsalud.org)
- Adamo GG, D'Angelo S, Yu AC, Pellegrini M, Bernabei F, Scorcia V, Giannaccare G. Bilateral Corneal Perforation in a Patient with Chronic Ocular Graft-Versus-Host Disease: A Case Report and Literature Review. (lidsen.com)
- Therefore, corneal perforation can occur as the presenting manifestation of ocular GVHD. (lidsen.com)
- 1-3 Gonococcal ophthalmia neonatorum can cause corneal scarring, ocular perforation, and blindness as early as 24 hours after birth. (uspreventiveservicestaskforce.org)
- A variable degree of ocular pain accompanies corneal ulceration. (vin.com)
- In recent past, the field of epigenetics has gained momentum and become an increasingly important area of biomedical research As far as eye is concerned, epigenetic mechanisms may play an important role in many complex diseases such as corneal dystrophy, cataract, glaucoma, diabetic retinopathy, ocular neoplasia, uveitis, and age-related macular degeneration. (frontiersin.org)
- 5 Complications from KCS include mucopurulent ocular discharge, conjunctivitis, corneal ulceration and infection, collagenolysis, and corneal perforation. (cliniciansbrief.com)
- We also offer a full range of ocular surgery for conditions including eyelid lacerations, deep corneal ulcers or perforations, uveitis, glaucoma, ocular/periocular tumors, and cataracts. (upenn.edu)
- Ophthalmic lasers have different tissue parameters that allow them to exert a wide variety of beneficial clinical effects on ocular tissue (e.g., photoablation, photocoagulation, fragmentation, or perforation). (aao.org)
Transplantation5
- Our strategy for corneal surface reconstruction includes amniotic membrane transplantation (AMT). (osref.org)
- A higher number of cases in the clear-graft group required surgical intervention in the form of corneal gluing and therapeutic corneal transplantation compared with the failed-graft group ( P = .03). (entokey.com)
- Diseases surgical technique developed since the start of the involving the corneal endothelium can be controlled twentieth century for the realization of corneal with endothelial or penetrating keratoplasties, and transplantation (CT). (bvsalud.org)
- CT is the most common type those diseases that involve both the endothelium and of tissue transplantation made around the world, the corneal stroma generally require PK when there is substitution of all corneal layers (the (REINHART, 2011). (bvsalud.org)
- BioCorneaVet is a good choice for corneal transplantation because it is easy to provided. (petseyes.cn)
Penetrating keratoplasty2
- Despite these benefits, surgeons commonly perform a penetrating keratoplasty for anterior corneal disorders because the latter technique is easier to perform, and lamellar transplants often show decreased best corrected visual acuity owing to irregular astigmatism and/or scarring at the donor to recipient interface. (bmj.com)
- With the development of new surgical techniques, instrumentation and pharmacological advances, corneal transplant procedures can undergo changes directly in the clinical profile of patients with the indication for penetrating keratoplasty technique. (bvsalud.org)
Management of impendi1
- The aim of this study was to evaluate the clinical results of surgical management of impending corneal perforations using double stromal lenticule obtained from SMILE surgery. (eg.net)
Ulcers5
- Corneal ulcers, melting and perforation of the eye can also occur with the more severe forms of the condition, impacting visual capacity. (pharmatimes.com)
- We produced corneal ulcers in New Zealand white rabbits using four normal sodium hydroxide, and studied the effects of vehicle placebo or of vehicle containing the protease which we expected to help degrade collagenase responsible for cleavage of corneal collagen. (uveitis.org)
- Visual impairment in fungal versus bacterial corneal ulcers four years after successful antimicrobial treatment. (aravind.org)
- The Ophthalmology Service treats eye conditions such as corneal ulcers, Equine Recurrent Uveitis, cataracts, and glaucoma. (upenn.edu)
- This article provides an overview of how to obtain a corneal culture in your own office as well as how to use it in your management of corneal ulcers. (reviewofoptometry.com)
Epithelium2
- In corneal ulceration there is a loss of epithelium plus varying amounts of stroma. (vin.com)
- Lagophthalmos also contributes to tear film deficiency (ie, increased evaporation of the aqueous portion of the trilaminar tear film), which further devitalizes the corneal epithelium, predisposing it to ulceration, collagenolysis, and infection. (cliniciansbrief.com)
Conjunctival1
- After applying the tissue adhesive , the dried membrane with glue applied then was positioned to cover the conjunctival bleb leak site or corneal perforation lesion using forceps . (bvsalud.org)
Visual Acuity2
- Postoperatively, the corneal perforations were successfully sealed in 16 (80%) patients, and 15 (75%) patients exhibited a statistically significant improvement in visual acuity ( P =0.02). (eg.net)
- Upon presentation, the examination may include a best-corrected visual acuity examination, a slit-lamp examination, indirect ophthalmoscopy, and Goldmann applanation tonometry (measurement of intraocular pressure by pressing and flattening an area on the corneal surface). (uspharmacist.com)
Stromal15
- After the microkeratome cut the corneal cap, it was stabilized with suction in the inverted position on a forming die while the refractive cut was made by a second pass of the instrument on the stromal side of the corneal cap. (aao.org)
- The reshaped free cap was sutured onto the patient's corneal stromal bed. (aao.org)
- In the late 1980s, Ruiz and Rowsey introduced tissue removal from the stromal bed rather than the free corneal cap, referred to as in situ keratomileusis. (aao.org)
- Purpose The aim of this study was to evaluate the safety and efficacy of double stromal lenticules, extracted by femtolaser small incision lenticule extraction (SMILE) surgery, as a surgical adjuvant for sealing of impending corneal perforation. (eg.net)
- Double corneal stromal lenticules obtained through SMILE surgery, with a central thickness of 65 μm for each lenticule, were fixed over the corneal impending perforation site by 10-0 nylon interrupted stitches. (eg.net)
- CONCLUSION With this technique a deep stromal anterior lamellar keratoplasty can be performed with the donor to recipient interface just anterior to the posterior corneal surface. (bmj.com)
- From the bottom of the incision, several corneal layers may be dissected until the desired depth of the recipient stromal bed is obtained. (bmj.com)
- With all these techniques the stromal dissection depth relative to the corneal thickness cannot be optically visualised. (bmj.com)
- If perforation occurs completion of the stromal dissection can be difficult, so that the donor button may have to be sutured into an imperfectly prepared recipient bed. (bmj.com)
- Using an alkali burn model of corneal ulceration in rabbits, we studied the effects and efficacy of application of a topical model protease on a model corneal wound healing and stromal ulceration. (uveitis.org)
- More importantly, corneal stromal ulceration was present in only 2 of the protease-treated eyes, whereas 46% of the placebo-treated eyes exhibited significant corneal ulceration. (uveitis.org)
- These preliminary results from these pilot studies suggest that, in addition to ant-collagenolytic therapy (for example with citrate and with medroxyprogesterone and with tetracycline), enhanced degradation of collagenase through the use of krill protease may be additionally beneficial in limiting the progression of alkali burn-induced corneal stromal degradation and ulceration. (uveitis.org)
- When used as a permanent graft, the aim of AMT is to fill in the corneal stromal defect. (osref.org)
- After securing the AM filling the defect, a larger layer of AM with the stromal surface facing down is laid and sutured to the healthy stroma with 10-O nylon in either interrupted or running (either zig-zag or purse string) fashion to make sure the top layer of membrane, which will act as a permanent graft, is in close contact with the corneal surface. (osref.org)
- with a long shelf-life and no need for refrigeration, it is a great solution for immediate availability in cases of near full thickness stromal replacement, such as in descemetoceles and even small perforating corneal defects in dogs and cats. (petseyes.cn)
Scleral2
Graft4
- If the perforation site is more than 2 mm in diameter, a tectonic graft will be needed to fill the defect. (osref.org)
- Eyes with corneal grafts may be vulnerable to infection because of exposed sutures, epithelial defects, graft hypoesthesia, and prolonged use of topical corticosteroids and eye drops with preservatives. (entokey.com)
- We are for sure interested in offering this kind of corneal graft more often. (petseyes.cn)
- A PKP procedure may be the best choice for patients who have certain eye diseases as well as those who have experienced rejection of a previous corneal graft. (cvpdaytoneyedoctors.com)
Tissue9
- A hyperdry amniotic membrane patch using a tissue adhesive for corneal perforations and bleb leaks. (bvsalud.org)
- To evaluate the efficacy of hyperdry amniotic membrane (AM) patching attached using a tissue adhesive for corneal perforations and glaucoma filtering bleb leaks. (bvsalud.org)
- corneal perforations , 3 eyes ) were treated with a single-layer patch of dried AM using a biological tissue adhesive . (bvsalud.org)
- Second, use of a cryolathe to freeze the corneal cap for precise lenticular reshaping of corneal tissue. (aao.org)
- In the mid-1980s, Swinger, Krumeich, and Cassiday developed a technique for removing corneal tissue without the cryolathe. (aao.org)
- The microkeratome was removed the corneal cap in a first pass, then the suction ring was changed to excise a free lenticle of tissue with a second pass. (aao.org)
- The posterior corneal surface is invisible through an operating microscope, owing to the small difference in the refractive index between corneal tissue and aqueous. (bmj.com)
- These substances can cause serious eye injuries, including scarring, perforation of eye tissue, and in extreme cases, blindness. (upmc.com)
- Ideal tissue incorporation and postoperative corneal transparency is well restored. (petseyes.cn)
Defects2
- Corneal defects/denervation. (hematologyadvisor.com)
- Persistent corneal epithelial defects. (nhp.gov.in)
Laceration1
- Mechanical injury such as corneal abrasion or laceration. (nhp.gov.in)
STROMA3
- 1-10 Commonly, the anterior stroma is incised with a trephine that can be set to a depth not exceeding the corneal thickness. (bmj.com)
- A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma. (bvsalud.org)
- A small round opacity without epithelial defect was observed in the stroma of the previous corneal incision wound ( Fig. 1A , arrow), but wound infection was not suspected initially because there was no epithelial defect. (ekjo.org)
Uveitis1
- A progression of superficial ulceration through deep ulceration to descemetocele formation and corneal rupture with uveitis and possible endophthalmitis can occur. (vin.com)
Edema1
- Examination may also reveal progressive vitritis, anterior chamber inflammation, and corneal edema. (uspharmacist.com)
Severe2
- If severe inflammation develops, corneal perforation can occur. (medscape.com)
- Depending on the concentration, formaldehyde solutions may cause transient discomfort and irritation or more severe effects, including corneal opacification and loss of vision. (cdc.gov)
Complications3
Ophthalmic1
- Ophthalmic signs of hypertriglyceridemia include xanthomas, xanthelasmas, and corneal arcus. (canadianjournalofophthalmology.ca)
Keratoconus3
- IMSEAR at SEARO: Sterile corneal perforation after cataract surgery in keratoconus posticus circumscriptus. (who.int)
- Angra SK, Chawdhary S. Sterile corneal perforation after cataract surgery in keratoconus posticus circumscriptus. (who.int)
- Corneal Perforation After Corneal Cross-Linking in Keratoconus Associated With Potentially Pathogenic ZNF469 Mutations. (cdc.gov)
Surgical2
- Conclusion The use of double corneal lenticules was a safe and effective surgical adjuvant for corneal perforation closure. (eg.net)
- Surgical and/or nonsurgical interventions are sometimes required to close the perforation to reform the collapsed anterior chamber and to restore the visual function [3] . (eg.net)
Incision1
- Nine months before the development of scleritis, he had received an uneventful phacoemulsification and intraocular lens insertion through a corneal incision. (ekjo.org)
Slit-lamp1
- Figure 1: (a) Solid, creamy, white mass lesion at 6 o'clock position (arrow) and self-sealed corneal perforation (arrowhead) seen on slit-lamp evaluation. (ijoreports.in)
Eyelid2
- This produces visible sclera between the eyelid margin and corneal limbus, which produces the appearance of a stare with an accompanying illusion of exophthalmos. (eyewiki.org)
- The distance from upper eyelid margin to corneal light reflex (margin reflex distance, MRD1) can be used to assess for elevated upper eyelid position. (eyewiki.org)
Infiltration1
- 3 Left untreated, the disease can progress to panophthalmitis (inflammation of the entire eye), corneal infiltration, perforation, orbital cellulitis, or phthisis bulbi (in which the eye is shrunken, atrophied, and nonfunctional). (uspharmacist.com)
Scrapings2
- Corneal scrapings were obtained for microbiological evaluation, specifically for Gram stain, Blankophor preparation, and culture in chocolate agar, Sabouraud's dextrose agar, and thioglycolate broth. (entokey.com)
- Intensive antimicrobial therapy was started after corneal scrapings and treatment was modified as indicated by culture results, sensitivity pattern, and clinical response. (entokey.com)
Opacification1
- Lagophthalmos is characterized by corneal opacification, related to progressive epithelial fibrosis and vascularization. (cliniciansbrief.com)
Keratopathy1
- Potential risk factors include conditions that predispose the patient to corneal melting, concurrent topical steroids, and epithelial keratopathy in the early postoperative period. (qxmd.com)
Lamellar3
- Jose I. Barraquer, MD, described corneal lamellar surgery for the correction of refractive error in 1949. (aao.org)
- in a seventh eye, perforation of the lamellar bed occurred. (bmj.com)
- 19 Lamellar dissection techniques therefore bear the risk of inadvertent perforation when deeper dissections are intended. (bmj.com)
Congenital1
- Congenital or acquired corneal anaesthesia. (nhp.gov.in)
Trauma2
- This technique involved less trauma to the corneal cap, but the results remained suboptimal secondary to unpredictable refractive changes and irregular astigmatism. (aao.org)
- Animals with pronounced macroblepharia can benefit from medial or lateral canthoplasty, a procedure that reduces the size of the palpebral fissure, improving blink quality and globe protection and potentially reducing corneal trauma. (cliniciansbrief.com)
Diseases1
- The innovative bioengineering technology has changed our manner in treating corneal diseases. (petseyes.cn)
Posterior1
- METHODS In eye bank eyes and sighted human eyes, aqueous was exchanged by air, to visualise the posterior corneal surface−that is, the "air to endothelium" interface. (bmj.com)
Eyes4
- Patients and methods The study included 20 eyes of 20 patients with impending corneal perforation. (eg.net)
- We reported the case of a 65-year-old male patient who developed corneal perforation sequentially in both eyes 3 years after receiving HSCT. (lidsen.com)
- Eighteen eyes of 16 patients with adverse corneal events associated with NSAID use. (qxmd.com)
- Corneal burn, or eye burn, can result when certain chemicals come into contact with your eyes. (upmc.com)
Disorders1
- Impending corneal perforation is an urgent condition caused by different types of infectious and noninfectious corneal disorders [1] . (eg.net)
Inflammation1
- Corneal damage can result in inflammation, scarring, loss of surface smoothness, irregular astigmatism, and loss of optical clarity. (medscape.com)