Corneal Neovascularization
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Sodium Hydroxide
Cornea
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Retinal Neovascularization
Choroidal Neovascularization
Alkalies
Angiogenesis Inhibitors
Neovascularization, Pathologic
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Ophthalmic Solutions
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Neovascularization, Physiologic
Cautery
Eye Injuries
Disease Models, Animal
Epithelium, Corneal
Antigens, CD31
Angiogenesis Inducing Agents
Silver Nitrate
Corneal Stroma
Corneal Transplantation
Corneal Opacity
Vascular Endothelial Growth Factors
Endothelial Growth Factors
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Lymphokines
Conjunctiva
Keratitis, Herpetic
Rabbits
Photosensitizing Agents
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Fluorescein Angiography
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Fluorescent Antibody Technique, Indirect
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Fibroblast Growth Factor 2
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Photochemotherapy
Keratoplasty, Penetrating
Thrombospondin 1
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Endothelium, Vascular
Vascular Endothelial Growth Factor Receptor-2
Vascular Endothelial Growth Factor Receptor-1
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Reverse Transcriptase Polymerase Chain Reaction
Cell Movement
Ischemia
Choroid
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Receptors, Vascular Endothelial Growth Factor
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Blotting, Western
Retinopathy of Prematurity
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Dendrimers
Laser Coagulation
Injections, Intraperitoneal
Visual Acuity
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Intravitreal Injections
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Cells, Cultured
In vivo significance of ICAM-1--dependent leukocyte adhesion in early corneal angiogenesis. (1/340)
PURPOSE: Numerous investigations have stressed the significance of leukocytes in early angiogenesis. Leukocytes invade the cornea, and the location of their extravasation corresponds to the site of vessel ingrowth. The interactions between leukocytes and vascular endothelium are mediated by various proteins, including adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). In this study, the role of ICAM-1 during early corneal angiogenesis was evaluated in vivo. METHODS: Corneal neovascularization was induced in New Zealand White rabbits by use of intrastromal pellets containing 750 ng vascular endothelial growth factor (VEGF). The fluorescent dye rhodamine 6G was used to stain leukocytes in vivo. Leukocyte adhesion and vessel growth were quantified in vivo by high-resolution fluorescence angiography. To inhibit ICAM-1 interactions a microemulsion containing anti-ICAM-1 antibody was applied topically. RESULTS: Limbal vessels showed increased leukocyte adhesion 24 hours after pellet implantation: The number of rolling and sticking leukocytes was significantly increased compared with the number in control animals (P < 0.01). Treatment with anti-ICAM-1 antibody resulted in reduced leukocyte sticking and increased leukocyte rolling. The area covered by new blood vessels was significantly diminished in eyes treated with anti-ICAM-1 (P < 0.05). CONCLUSIONS: The results support the hypothesis that ICAM-1-mediated leukocyte adhesion is a key event in early angiogenesis. This model may serve for investigation of the significance of adhesion molecules by in vivo observation and quantification. (+info)Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. (2/340)
Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokinase-activated plasmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease-activated kringles 1-5). K1-5 inhibits endothelial-cell proliferation with a half-maximal concentration of approximately 50 pM. This inhibitory effect is endothelial-cell-specific and appears to be at least approximately 50-fold greater than that of angiostatin. A synergistic efficacy of endothelial inhibition was observed when angiostatin and kringle 5 (K5) were coincubated with capillary endothelial cells. The synergistic effect is comparable to that produced by K1-5 alone. Systemic treatment of mice with K1-5 at a low dose significantly blocked the fibroblast growth factor-induced corneal neovascularization, whereas angiostatin had no effect at the same dose. K1-5 also suppressed angiogenesis in chicken embryos. Systemic administration of K1-5 at a low dose at which angiostatin was ineffective significantly suppressed the growth of a murine T241 fibrosarcoma in mice. The antitumor effect correlates with the reduced neovascularization. These findings suggest that the plasmin-mediated proteolysis may be involved in the negative switch of angiogenesis. (+info)Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization. (3/340)
PURPOSE: To investigate the expression of cell-adhesion molecules on corneolimbal and neovascular endothelium and the associated leukocyte infiltration in an experimental model of inflammatory corneal neovascularization (NV). METHODS: Corneal NV was induced in BALB/c mice by placement of nylon sutures. Interleukin-1 receptor antagonist (IL-1ra) was used topically to determine whether suppression of IL-1 could affect adhesion molecule expression and leukocytic infiltration. At set time points, corneal samples were analyzed immunohistochemically for expression of P-selectin, E-selectin, intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, and platelet- endothelial adhesion molecule (PECAM)-1. Leukocytic infiltration at different time points was quantified histologically. In companion experiments mice deficient in ICAM-1 were investigated to determine the functional relevance of this molecule in corneal leukocyte infiltration. RESULTS: Significant enhanced expression of ICAM-1 was detected on the corneolimbal vascular endothelium as early as 8 hours and on the newly formed corneal NV by day 3, and treatment with IL-1ra led to significant suppression of this expression. IL-1ra-induced suppression of ICAM-1 expression was accompanied by a profound decrease in corneal leukocytic infiltration by 44.6% at day 1 (P < 0.003), 71.8% at day 3 (P < 0.001), 60.1% at day 7 (P < 0.001), and 63.8% at day 14 (P < 0.001), compared with control corneas. Similarly, in ICAM-1 knockout mice, the corneal leukocytic infiltration was 50.3%, 52.9%, and 36.4%, compared with wild-type control animals on day 1 (P < 0.001), day 7 (P < 0.005), and day 14 (P < 0.001), respectively. Expression of PECAM-1 was constitutively present on perilimbal vascular endothelium and had no response to IL-1ra treatment. No significant expression of P-selectin, E-selectin, or VCAM-1 was detected in this experimental model. CONCLUSIONS: These results suggest that leukocytic infiltration in this model of inflammatory corneal NV is closely associated with ICAM-1 expression, and that topical IL-1ra displays corneal anti-inflammatory effects, largely by suppressing ICAM-1 expression on vascular endothelial cells. (+info)VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. (4/340)
Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypothesis that VEGF may modulate endothelial progenitor cell (EPC) kinetics for postnatal neovascularization. Indeed, we observed an increase in circulating EPCs following VEGF administration in vivo. VEGF-induced mobilization of bone marrow-derived EPCs resulted in increased differentiated EPCs in vitro and augmented corneal neovascularization in vivo. These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis. (+info)Inhibition of rat corneal angiogenesis by 16-kDa prolactin and by endogenous prolactin-like molecules. (5/340)
PURPOSE: The cornea is an avascular organ, where induction of new blood vessels involves the turn-on of proangiogenic factors and/or the turn-off of antiangiogenic regulators. Prolactin (PRL) fragments of 14 kDa and 16 kDa bind to endothelial cell receptors and inhibit angiogenesis. This study was designed to determine whether antiangiogenic PRL-like molecules are involved in cornea avascularity. METHODS: Sixteen-kDa PRL and basic fibroblast growth factor (bFGF) or anti-PRL antibodies were placed into rat cornea micropockets and neovascularization evaluated by the optical density associated with capillaries stained by the peroxidase reaction and by the number of vessels growing into the implants. Prolactin receptors in corneal epithelium were investigated by immunocytochemistry. RESULTS: bFGF induced a dose-dependent stimulation of corneal neovascularization. This effect was inhibited by coadministration of 16-kDa PRL, as indicated by a 65% reduction in vessel density and a 50% decrement in the incidence of angiogenic responses. Corneal angiogenic reactions of different intensities were induced by implantation of polyclonal and monoclonal anti-PRL antibodies. Corneal epithelial cells were labeled by several anti-PRL receptor monoclonal antibodies. CONCLUSIONS: These findings show that exogenous 16-kDa PRL inhibits bFGF-induced corneal neovascularization and suggest that PRL-like molecules with antiangiogenic actions function in the cornea. PRL receptors in the corneal epithelium may imply that PRL in the cornea derives from lacrimal PRL internalized through an intracellular pathway. These observations are consistent with the notion that members of the PRL family are potential regulators of corneal angiogenesis. (+info)Nitric oxide synthase-II is expressed in severe corneal alkali burns and inhibits neovascularization. (6/340)
PURPOSE: Inducible nitric oxide synthase (NOS-II) is expressed in many inflammatory conditions. The implication of nitric oxide (NO) in angiogenesis remains controversial. The role of NOS-II and its influence on angiogenesis in corneal neovascularization is unknown and was investigated in this study. METHODS: A mouse model of corneal neovascularization induced by chemical cauterization was used. NOS-II mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction, and NOS-II protein was studied in situ by immunohistochemical analysis of the cornea. The influence of NOS-II on neovascularization was determined by comparison of vessel development in "normal" wild-type mice and mice with a targeted disruption of the NOS-II gene. RESULTS: NOS-II mRNA was induced to very high levels after corneal cauterization and remained upregulated throughout the disease. Migratory cells in the center of the cauterization area expressed NOS-II protein. The neovascular response in mice lacking the NOS-II gene was significantly stronger than in wild-type mice, and the difference increased over time. CONCLUSIONS: These data are the first evidence that NOS-II is expressed in this model of sterile corneal inflammation. NOS-II expression inhibited angiogenesis in severe corneal alkali burns. (+info)IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. (7/340)
Few studies have addressed the importance of vascular remodeling in the lung during the development of bleomycin-induced pulmonary fibrosis (BPF). For fibroplasia and deposition of extracellular matrix to occur, there must be a geometric increase in neovascularization. We hypothesized that net angiogenesis during the pathogenesis of fibroplasia and deposition of extracellular matrix during BPF are dependent in part on a relative deficiency of the angiostatic CXC chemokine, IFN-gamma-inducible protein-10 (IP-10). To test this hypothesis, we measured IP-10 by specific ELISA in whole lung homogenates in either bleomycin-treated or control mice and correlated these levels with lung hydroxyproline. We found that lung tissue from mice treated with bleomycin, compared with that from saline-treated controls, demonstrated a decrease in the presence of IP-10 that was correlated to a greater angiogenic response and total lung hydroxyproline content. Systemic administration of IP-10 significantly reduced BPF without any alteration in lung lymphocyte or NK cell populations. This was also paralleled by a reduction in angiogenesis. Furthermore, IP-10 had no direct effect on isolated pulmonary fibroblasts. These results demonstrate that the angiostatic CXC chemokine, IP-10, inhibits fibroplasia and deposition of extracellular matrix by regulating angiogenesis. (+info)Effects of 1alpha,25-dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice. (8/340)
PURPOSE: To examine the effects of 1alpha,25-dihydroxyvitamin D3 (1alpha,25[OH]2D3), a hormone that has immunosuppressive properties, on Langerhans cell (LC) migration and corneal neovascularization in mouse corneas. METHODS: Two 10-0 nylon interrupted sutures were placed in the center of 50 BALB/c mouse corneas to induce LC migration and corneal neovascularization. The mice were then randomly assigned to one of five groups. Three groups (n = 11, n = 11, n = 6) received topical 1alpha,25(OH)2D3 (at concentrations of 10(-7) M, 10(-)8 M, 10(-9) M), one group (n = 11) received vehicle only, and one group (n = 11) received no eye drops. Instillation (three times a day) began on the first day after suturing. Corneal neovascularization was assessed by slit lamp microscopy and scored according to the length of newly formed corneal vessels. Fourteen days after suturing, the number of LCs that had migrated into the central corneal epithelium was counted by an immunofluorescence assay using an anti-Ia antibody. RESULTS: The number of LCs in the central cornea was 21.9 +/- 2.8 cells/mm2 in the nontreated group and 17.8 +/- 3.9 cells/mm2 in the vehicle-only group. Significantly fewer LCs were detected in all groups that had received 1alpha,25(OH)2D3 compared with the vehicle only and nontreated groups (10(-7) M: 7.4 +/- 1.2 cells/mm2, 10(-8) M: 7.2 +/- 2.0 cells/mm2, 10(-9) M: 6.2 +/- 0.7 cells/mm2). Moderate inhibition of corneal vascularization was observed in the 10(-7) M 1alpha,25(OH)2D3 group, but not the other groups. CONCLUSIONS: Topical administration of 1alpha,25(OH)2D3 can be effective in suppressing ocular surface inflammation by inhibiting LC migration into mouse corneas. (+info)
Inhibition of Experimental Corneal Neovascularization by Diclofenac, Ketorolac, and Etanercept | IOVS | ARVO Journals
Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions - Tabular View -...
Corneal neovascularization - Wikipedia
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DiVA - Sökresultat
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Omega Research
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Metalloproteinase Expression in Corneal Wounds - Dimitri Azar
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Corneal neovascularization
... (CNV) is the in-growth of new blood vessels from the pericorneal plexus into avascular corneal ... If the cornea is inflamed via corneal neovascularization, the suppression of enzymes can block CNV by compromising with corneal ... Maintaining avascularity of the corneal stroma is an important aspect of corneal pathophysiology as it is required for corneal ... Corneal neovascularization has become more common worldwide with an estimated incidence rate of 1.4 million cases per year, ...
Neovascularization
Choroidal neovascularization Corneal neovascularization Revascularization Rubeosis iridis Inosculation Neely, Kimberly A.; ... Corneal neovascularization is a condition where new blood vessels invade into the cornea from the limbus. It is triggered when ... Neovascularization in the eye can cause a type of glaucoma (neovascularization glaucoma) if the new blood vessels' bulk blocks ... "Treatment of Corneal Neovascularization". EyeNet Magazine. American Academy of Ophthalmology: 35-6. Retrieved 14 July 2020. ...
Pericorneal plexus
"Corneal Neovascularization: An Anti-VEGF Therapy Review". Survey of Ophthalmology. 57 (5): 415-429. Retrieved 2022-11-26. v t e ...
Tyrosine phosphorylation
Hayashi A, Popovich KS, Kim HC, de Juan E (1997). "Role of protein tyrosine phosphorylation in rat corneal neovascularization ...
Lanepitant
... such as corneal neovascularization. "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended ... "NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 ( ...
Befetupitant
"NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 ( ... has however continued to be researched for other possible applications such as treatment of corneal neovascularization. ...
Hutchinson's patch
The sign is an indication of interstitial (or parenchymatous) keratitis, causing corneal neovascularisation. Blood vessels ...
Pemphigoid
Besides, reduced tearing with erosion and neovascularization of the cornea leads to corneal opacification and perforation. ...
Mustard gas
... and neovascularization. In these severe and infrequent cases, corneal transplantation has been used as a treatment option. ... Extreme ocular exposure to mustard gas vapors may result in corneal ulceration, anterior chamber scarring, ...
Prostaglandin EP4 receptor
This result suggests that EP4 activation contributes to corneal neovascularization and that EP4 antagonists may be useful for ... A selective EP4 antagonists significantly reduced corneal neovascularization in rats caused by oxygen-induced retinopathy or ... corneal endothelium, corneal keratocytes, trabecular cells, ciliary epithelium, conjunctival stromal cells, and iridal stromal ...
Blepharitis
... corneal neovascularization, and ulceration. Patients with an inflammatory eyelid lesion that appears suspicious of malignancy ... This serves as a primary indication of regional dryness in the pre-corneal tear film after fluorescein injections. If TBUT is ... Other signs may include telangiectasia on the anterior eyelid, collarettes encircling the lash base, and corneal changes. ... and corneal ulcer or irritation. The lids may become red and may have ulcerate, non-healing areas that may lead to bleeding. ...
LASIK
... sometimes resulting in corneal neovascularization-the growth of blood vessels into the cornea. This causes a slight lengthening ... Both the depth of the corneal incisions and the degree of central corneal flattening correlated with the laser energy applied. ... Those with Fuchs' corneal endothelial dystrophy, corneal epithelial basement membrane dystrophy, retinal tears, autoimmune ... are made of materials with greater oxygen permeability that help reduce the risk of corneal neovascularization, patients ...
Eye disease
Corneal neovascularization (H18.5) Fuchs' dystrophy - cloudy morning vision (H18.6) Keratoconus - degenerative disease: the ... Corneal ulcer / Corneal abrasion - loss of the surface epithelial layer of the eye's cornea (H16.1) Snow blindness / Arc eye - ... a rare congenital eye condition leading to underdevelopment or even absence of the iris of the eye Endophthalmitis Corneal ...
List of ICD-9 codes 320-389: diseases of the nervous system and sense organs
Interstitial and deep keratitis 370.6 Corneal neovascularization 370.8 Other forms of keratitis 370.9 Unspecified 371 Corneal ... cornea 371.0 Corneal scars and opacities 371.1 Corneal pigmentations and deposits 371.2 Corneal oedema 371.3 Changes of corneal ... membranes 371.4 Corneal degenerations 371.5 Hereditary corneal dystrophies 371.6 Keratoconus 371.7 Other corneal deformities ... one eye 369.9 Unspecified visual loss 370 Keratitis 370.0 Corneal ulcer 370.1* Dendritic keratitis (054.4†) 370.2 Other ...
Ribonucleotide reductase
In mice models of stromal keratitis and corneal neovascularization (HSV ocular disease), a small RNR2 C-terminal analog BILD ...
Aganirsen
Phase III in progressive corneal neovascularisation in patients with infectious keratitis and on the waiting list for Corneal ... including progressive corneal neovascularization in patients with infectious keratitis and wet age related macular degeneration ... "GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial" ... "Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for ...
List of MeSH codes (C11)
... corneal edema MeSH C11.204.290 - corneal neovascularization MeSH C11.204.299 - corneal opacity MeSH C11.204.299.070 - arcus ... corneal ulcer MeSH C11.294.354 - eye infections, bacterial MeSH C11.294.354.220 - conjunctivitis, bacterial MeSH C11.294. ... corneal dystrophies, hereditary MeSH C11.270.162.438 - Fuchs' endothelial dystrophy MeSH C11.270.235 - duane retraction ... retinal neovascularization MeSH C11.768.740 - retinal perforations MeSH C11.768.757 - retinal vasculitis MeSH C11.768.760 - ...
Chi Hwan Lee
... such as corneal neovascularization, in a rabbit model without showing a noticeable side effect over current standard therapies ... All-printed corneal electrodes on soft contact lenses for noninvasive recording of human electroretinogram, Nature ...
CYR61
... has potent angiogenic activity upon endothelial cells and induces neovascularization, first demonstrated in a corneal ... enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic ...
Rubeosis iridis
... choroidal neovascularization) CNV (corneal neovascularization) NVD (neovascularization of the disc) "rubeosis iridis" at ... Once the neovascularization has been longstanding, the new vessels recruit fibrous tissue, and as this forms and contracts, the ... Rubeosis iridis is a medical condition of the iris of the eye in which new abnormal blood vessels (formed by neovascularization ... If caught early, the neovascularization can be reversed with prompt panretinal photocoagulation (PRP), or injection of anti- ...
List of contact lens complications
Corneal epithelial infiltrates Keratitis Corneal ulcer Corneal stroma Corneal neovascularisation Corneal oedema Corneal ... Ptosis Giant papillary conjunctivitis Superior limbic keratoconjunctivitis Epithelium Corneal abrasion Corneal erosion Contact ... infiltrates Corneal endothelium Endothelial polymegathism Effects of long-term contact lens wear on the cornea (Articles ...
Ocular immune system
... but also neovascularization (formation of new blood vessels), which can lead to a loss of corneal transparency. Therefore, the ... Corneal nerves serve as a form of defense by detecting the presence of foreign bodies on the corneal surface. This leads to ... Corneal epithelial cells present a physical barrier to prevent microbes from reaching the interior of the eye chamber, which is ... Tears bathe corneal epithelial cells in a moist environment, preventing them from drying out and weakening. However, the liquid ...
Cornea
Corneal neovascularization - excessive ingrowth of blood vessels from the limbal vascular plexus into the cornea, caused by ... Corneal pachymetry Corneal reflex Corneal tattooing Corneal topography Eye disease Keratometry List of keratins expressed in ... For corneal epithelial diseases such as Stevens Johnson Syndrome, persistent corneal ulcer etc., the autologous contralateral ( ... There is a global shortage of corneal donations, severely limiting the availability of corneal transplants across most of the ...
Muse cell
... and reduced the severity of corneal inflammation and neovascularization. cell-SCC retained the capacity to suppress corneal ... in mouse and tree shrew wounded corneas prevented the formation of corneal scarring, increased corneal re-epithelialization and ... Corneal scarring Human Muse cells, collected from lipoaspirate, were activated by forming spheroid in the dynamic rotary cell ... These activated Muse spheroids enabled ready differentiation into corneal stromal cells (CSCs) expressing characteristic marker ...
Contact lens
... corneal ulcers and corneal neovascularization-this latter condition, once it sets in, cannot be reversed and will eventually ... corneal edema, descemetocele, corneal ectasia, Mooren's ulcer, anterior corneal dystrophy, and neurotrophic ... The most prominent risks associated with long-term, chronic low oxygen to the cornea include corneal neovascularization, ... "The Corneal Lens", The Optician, 2 September 1949, pp. 141-144. "Corneal Contact Lenses", The Optician, 9 September 1949, p. ...
Ocular ischemic syndrome
The corneal layers show edema and striae. There is mild anterior uveitis. A cherry-red spot may be seen in the macula, along ... The condition leads to neovascularization in various eye tissues due to the ischemia. The eye pressure may become high due to ... general ocular ischemia may result in retinal neovascularization, rubeosis iridis, cells and flare, iris necrosis, and cataract ...
Fuchs heterochromic iridocyclitis
Neovascularisation (growth of new abnormal vessels) is possible and any eye surgery, such as cataract surgery, can cause ... and keratitic precipitates on the posterior corneal surface. Patients are often asymptomatic and the disease is often ...
Dry eye syndrome
... corneal ulceration (sterile and infected), corneal neovascularization, corneal scarring, corneal thinning, and even corneal ... Some severe cases result in thickening of the corneal surface, corneal erosion, punctate keratopathy, epithelial defects, ... in which the corneal nerves which stimulate tear secretion are cut during the creation of a corneal flap. Dry eye caused by ... Tear osmolarity may be a more sensitive method of diagnosing and grading the severity of dry eye compared to corneal and ...
Mir-184
High expression is observed in suprabasal cells of the corneal epithelium in the mouse model, along with expression in mouse ... miR-184 has been implicated in ischemia-induced retinal neovascularization. Dysregulation of miRNA expression is thought to ... In mammals, mature miR-184 is particularly enriched in the brain and testis, along with the corneal epithelium. Depolarization ... Finally, a recent study identified miR-184 as essential for embryonic corneal commitment of pluripotent stem cells. • A single ...
Neurotrophic keratitis
... spontaneous corneal epithelium breakdown, poor corneal healing and development of corneal ulceration, melting and perforation. ... Long-lasting neurotrophic keratitis may also cause hyperplasia of the epithelium, stromal scarring and neovascularization of ... Corneal contact lenses can also be used in this stage of the disease, for their protective action to improve corneal healing. ... Corneal sensitivity test: performed by placing a cotton wad or cotton thread in contact with the corneal surface: this only ...
List of OMIM disorder codes
VSX1 Corneal dystrophy, lattice type I; 122200; TGFBI Corneal dystrophy, lattice type IIIA; 608471; TGFBI Corneal dystrophy, ... with choroidal neovascularization; 608161; PRPH2 Fragile X syndrome; 300624; FMR1 Fragile X tremor/ataxia syndrome; 300623; ... ZEB1 Corneal dystrophy, gelatinous drop-like; 204870; TACSTD2 Corneal dystrophy, Groenouw type I; 121900; TGFBI Corneal ... TGFBI Corneal dystrophy, Thiel-Behnke type; 602082; TGFBI Corneal endothelial dystrophy 2; 217700; SLC4A11 Corneal endothelial ...
Proteases in angiogenesis
... indicating impaired neovascularization. Neovascularization also is impaired in mice treated with bone marrow derived cells ... Kato, T; Kure, T; Chang, JH; Gabison, EE; Itoh, T; Itohara, S; Azar, DT (2001). "Diminished corneal angiogenesis in gelatinase ... Both enzymes inhibit bFGF induced vascularization in the corneal pocket assay and inhibit VEGF induced angiogenesis in the ... VEGF121 and the truncated VEGF165, in contrast, cause irregular patterns of neovascularization, most likely due to their ...
Perlecan
A similar result was produced in the corneal micropocket assay, where FGF-2 is implanted into the cornea of mice and in normal ... While Perlecan suppression causes substantial inhibition of tumor growth and neovascularization in null mice, in contrast, when ... Corneal opacification occurred in both transgenic lines early in development due to greatly increased expression of perlecan, ... Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC (June 2006). "Basement membrane dissolution and reassembly by limbal corneal ...
Hyphema
Surgery can be effective for cleaning out the anterior chamber and preventing corneal blood staining. If pain management is ... Spontaneous hyphemas are usually caused by the abnormal growth of blood vessels (neovascularization), tumors of the eye ( ... corneal blood staining, and atrophy of the optic nerve. Small hyphemas can usually be treated on an outpatient basis. There is ... corneal staining, optic atrophy, or vision loss. Rebleeding occurs in 4-35% of hyphema cases and is a risk factor for glaucoma ...
Thiomer
Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. Polym. 179: 42-49. doi:10.1016/j. ... of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization". ... Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. Polym. 179: 42-49. doi:10.1016/j. ...
Scleral reinforcement surgery
Neovascularization may occur, causing blood vessels to protrude through the cracks and leak in the space underneath the ... First, the conjunctiva and Tenon's capsule are incised about 6 mm from the corneal limbus. The lateral, superior, and inferior ...
PEDF
... suppresses retinal neovascularization and endothelial cell proliferation. The antiangiogenic residues 24-57 were shown to ... "Pigment Epithelium-derived Factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease ... PEDF, a protein with many functions, has been suggested to play a clinical role in dry eye, choroidal neovascularization, ... Molecules that shift the balance towards PEDF and away from VEGF may prove useful tools in both choroidal neovascularization ...
Fundus photography
Early fundus photos were limited by insufficient light, long exposures, eye movement, and prominent corneal reflexes that ... This is a method of better observing intraretinal microvascular abnormalities, neovascularization at the disc and elsewhere in ...
Gholam A. Peyman
... he applied for a patent that described a method of modifying corneal refractive errors using laser ablation under a corneal ... Oscillatory photodynamic therapy for choroidal neovascularization and central serous retinopathy; a pilot study (2013). ... "INTRASTROMAL CORNEAL MODIFICATION"; 6,221,067, granted April 2001, entitled "CORNEAL MODIFICATION VIA IMPLANTATION"; and others ... In October 2009 Peyman invented and applied for a patent on a method of preventing corneal implant rejection, which was ...
Neovascularization, Corneal, CL-related Differential Diagnoses
Ocular insult, including infectious keratitis, immunological conditions, corneal trauma, alkali injury, and contact lens wear ( ... CL), can encourage new blood vessels to grow from the limbus and, hence, neovascularization (NV). ... encoded search term (Neovascularization%2C Corneal%2C CL-related) and Neovascularization, Corneal, CL-related What to Read Next ... Neovascularization, Corneal, CL-related Differential Diagnoses. Updated: Apr 18, 2018 * Author: Barry A Weissman, OD, PhD, FAAO ...
'Corneal Neovascularization - Pipeline Review, H1 2014' is now available at Fast Market Research |...
Corneal Neovascularization - Pipeline Review, H1 2014, provides an overview of the Corneal Neovascularizations therapeutic ... "Corneal Neovascularization - Pipeline Review, H1 2014" is now available at Fast Market Research. From: Fast Market Research, ... Choroidal Neovascularization - Pipeline Review, H1 2014 - Corneal Graft Rejection - Pipeline Review, H1 2014 - Type 1 Diabetes ... The report provides a snapshot of the global therapeutic landscape of Corneal Neovascularization * The report reviews key ...
Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk...
Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk ... Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk ... timing and risk factors of corneal neovascularisation (NV) after deep anterior lamellar keratoplasty (DALK) for corneal ectasia ... The presence and severity of corneal NV was ascertained based on slit lamp photographs. Potential risk factors for corneal NV ...
Neovascularization, Corneal, CL-related: Background, Pathophysiology, Epidemiology
Ocular insult, including infectious keratitis, immunological conditions, corneal trauma, alkali injury, and contact lens wear ( ... CL), can encourage new blood vessels to grow from the limbus and, hence, neovascularization (NV). ... encoded search term (Neovascularization%2C Corneal%2C CL-related) and Neovascularization, Corneal, CL-related What to Read Next ... Neovascularization, Corneal, CL-related. Updated: Apr 18, 2018 * Author: Barry A Weissman, OD, PhD, FAAO; Chief Editor: Hampton ...
Corneal Neovascularization
METHODS: A patient presenting with severe corneal neovascularization in both eyes and Hand Motion (HM) vision was given ... Corneal Neovascularization, Triamcinolone Acetonide and Steroids Michael A. Singer, MD (San Antonio, TX), Rafael Lin Wong, (San ... To determine whether combination therapy of Avastin and Kenalog is useful in the treatment of corneal neovascularization. ...
Corneal neovascularization | Contact Lens Update
Corneal neovascularization. Vessel penetration at the limbus into the cornea beyond the translucent zone. The vessels may empty ... Localized neovascularization may appear subsequent to trauma or inflammatory events. When fitting a patient with silicone ... hydrogel lenses on an EW schedule, baseline neovascularization should not exceed 0.5mm. ...
Final Report Summary - STRONG (European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular...
Its efficacy when applied topically in corneal neovascularization has already been demonstrated. Phase I-III trials in the ... It only reduces the oxygen demand of the retina, and thus leads to a regression of the neovascularizations. It is clear that, ... Anti-proliferative laser or cryo treatment of the retina must be performed in iCRVO as soon as neovascularizations are ... The resultant growth of new vessels in the anterior chamber angle (neovascularization of the angle [NVA]) and iris surface ( ...
Allergic Conjunctivitis Workup: Approach Considerations, Histologic Findings
Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1<...
Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. In: ... Dive into the research topics of Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus ... Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. / Zhou ... Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. ...
Category:Blood vessels - Wikimedia Commons
nowiki,vaso sanguíneo; Æð; خوٗن رَگہٕ; pembuluh darah; ਲਹੂ ਨਾੜ; 血管; Hoeh-kńg; د وینې رګ; Кръвоносен съд; Monsisá; kan damarı; رگ; asinsvadi; Xidid; blodkärl; krvni sud; кровоносні судини; ناڑ; 血管; Vaskulo; Xwînborî; 혈관; Қан тамырлары; sanga vaskulo; крвни садови; Krvni sud; bloedvat; রক্তবাহ; vaisseau sanguin; Pembuluh Darah; ڤمبولوه داره; ލޭހޮޅި; Imibhobho yokuhamba kwegazi; naczynie krwionośne; אדער; pembuluh darah; vas sangvin; mạch máu; قان تامىرلارى; Qan tamırları; Bloedvat; крвни суд; Миаш; Sirka; Tsinga; bluid vessel; Қан тамырлары; blodåre; blodåre; Qan damarları; Enët e gjakut; Suun; ಧಮನಿ; vorrâsuonâ; blood vessel; وعاء دموي; крвни суд; हिनू; vas sanguini; 血管; Кан тамырлар; የደም ቧንቧ; véredény; odol-hodi; кровеносные сосуды; ...
Medicine, Cardiology Division - Grants - Northwestern Scholars
MIR335 microRNA 335 [Homo sapiens (human)] - Gene - NCBI
Eye Health Conditions | Case Definitions and Data Indicators | Project Description | Vision and Eye Health Surveillance System ...
... corneal neovascularization, or other or unspecified forms of keratitis.. Conjunctivitis. Conjunctivitis includes diagnosis ... Other Corneal disorders. Other Corneal disorders includes diagnosis codes indicating corneal scars, opacities and other ... Choroidal neovascularization AMD. Choroidal neovascularization AMD indicates the presence of ICD10 codes approved after October ... Because this is a new code, Choroidal neovascularization AMD is included in VEHSS as a subgroup of Wet-form AMD.. ...
Severe Ocular Cowpox in a Human, Finland - Volume 21, Number 12-December 2015 - Emerging Infectious Diseases journal - CDC
At 1 year after symptom onset, corneal limbal stem cell deficiency with deep corneal neovascularization was evident. Autologous ... resulting in stable corneal surface 2 months later (Technical Appendix Figure, panel G). Neovascularization regressed, the ... Graef S, Kurth A, Auw-Haedrich C, Plange N, Kern WV, Nitsche A, Clinicopathological findings in persistent corneal cowpox ... and corneal melting progressed (Technical Appendix Figure, panel E). Corneal collagen cross-linking and a fourth AMT were ...
US Patent Application for Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or...
Example 27 Galectin-3 Specific Inhibitor Reduced Corneal Neovascularization Neovascularization in corneas which may occur from ... Thus TD139 was observed to be an effective in vivo inhibitor of corneal neovascularization, which is an important system of ... Example 29 TD139 Inhibited Corneal Fibrosis SMA (smooth muscle actin) is a marker of corneal fibrosis. Eyes were treated with ... or corneal neovascularization (trachoma).. The galectin protein in various embodiments of the method is selected from the group ...
Dry Eye Disease (Keratoconjunctivitis Sicca) Medication: Ophthalmic Lubricants, LFA-1 Antagonists, Mucolytic Agents,...
It decreases inflammation and corneal neovascularization, suppresses migration of PMNs, and reverses capillary permeability. It ... Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci. 1983 Oct. 24 (10):1442 ... Serum eye drops are used for severe dry eye disease with punctate epithelial defects and corneal damage to promote ... Intercellular adhesion molecule-1 (ICAM-1) may be overexpressed in corneal and conjunctival tissues in dry eye disease. The ...
Other Eye Disorders - Infectious and Inflammatory Diseases | Vision and Eye Health Surveillance System (VEHSS) | Vision Health...
World Journal of Gastroenterology - Baishideng Publishing Group
An Update on Novel Ocular Nanosystems with Possible Benefits in the Treatment of Corneal Neovascularization. Int J Nanomedicine ... miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization. Graefes Arch Clin Exp ... Mimouni M, Ouano D. Initial outcomes of mitomycin intravascular chemoembolization (MICE) for corneal neovascularization. Int ... Pharmacological Inhibition of Glutaminase 1 Attenuates Alkali-Induced Corneal Neovascularization by Modulating Macrophages. ...
RFA-RM-17-030: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and...
Interaction between Bevacizumab and Murine VEGF-A: A Reassessment | IOVS | ARVO Journals
As early as 1998, Amano et al. 13 showed that VEGF is required for wound- and inflammation-related corneal neovascularization ... Other studies showed that VEGF is also important for corneal neovascularization associated with herpes simplex virus infection ... Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization. Invest ... The area of neovascularization was selected by freehand draw, and a pixel/length ratio of 194 pixel/wound diameter was applied ...
Optical Coherence Tomography Angiography in Herpetic Leucoma | Research Square
Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. Invest Ophthalmol ... Chan SY, Pan CT, Feng Y. Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography. Cornea. ... En face optical coherence tomography angiography for corneal neovascularisation. BrJ Ophthalmol. 2016; 100 (5):616-621. https ... HSV: Herpes Simplex Virus; OCTA: Optical Coherence Tomography Angiography; VD: Vessel Density; CoNV: Corneal Neovascularization ...
Dr. James Reidy, MD - Chicago, IL | Ophthalmology
Lipid hydrooeroxide induced corneal neovascularization Ueda T, Jenis E, Chou R, Spengler R, Reidy J, and Armstrong D, Invest ... Short-term regression of corneal neovascularization with combination therapy of argon green laser photocoagulation and ... Human corneal stem cells display functional neuronal properties Seigel GM, Sun W, Salvi R, Campbell LM, Sullivan S, Reidy JJ, ... Human corneal stem cells display functional neuronal properties Reidy JJ, Seigel GM, Sun W, Salvi R, Campbell LM, Sullivan S, ...
Gammaplex (Human Immunoglobulin G) - Current Clinical Trials
Pseudomonas aeruginosa Corneal Infection Related
to Mascara Applicator Trauma -- Georgia
... a dense inflammatory corneal infiltrate was present. Subsequently, diffuse neovascularization of the cornea developed; vision ... Gram stain of corneal scrapings revealed gram-negative rods. Culture of the corneal scrapings and of a sample of the patients ... Pseudomonas aeruginosa Corneal Infection Related to Mascara Applicator Trauma -- Georgia On January 11, 1989, a 47-year-old ... Pseudomonas-induced corneal ulcer associated with contaminated eye mascaras. Am J Ophthalmol 1977;84:112-9. ...
Fast Five Quiz: Erythema Multiforme
尋找研究成果 - 臺北醫學大學
Step Up To LK
Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin). Ocul ... with worse neovascularization due to the intense inflammatory response and potential subsequent hemorrhaging, corneal thinning ... Zimprich notes that neovascularization can form in the absence of inflammation; therefore, if the etiology is not inflammatory ... "This condition, whether idiopathic or secondary to corneal or systemic disease, typically opacifies and can interfere with ...
The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis
... and bFGF-induced corneal neovascularization in vivo [8]. Moreover, a similar observation also displayed the inhibition of VEGF- ... K. Amano, M. Okigaki, Y. Adachi et al., "Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice," ... K. L. Kim, S. Seo, J. T. Kim et al., "SCF (stem cell factor) and cKIT modulate pathological ocular neovascularization," ... COX2 also mediates IL1 beta-induced angiogenesis in vitro and in vivo [122, 123]. IL1 beta supports neovascularization through ...
Colin Willoughby - Research output
- Ulster University
Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization. Spiteri, N., ... Angiographic and In Vivo Confocal Microscopic Characterization of Human Corneal Blood and Presumed Lymphatic Neovascularization ... Femtosecond Laser-Assisted Lamellar Keratectomy for Corneal Opacities Secondary to Anterior Corneal Dystrophies. Steger, B., ... Collagen corneal shields. Willoughby, C. E., Batterbury, M. & Kaye, S. B., 2002, In: Survey of Ophthalmology. 47, 2, p. 174-182 ...