AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, Agriculture
Corneal NeovascularizationEye BurnsBurns, ChemicalSodium HydroxideCorneaRetinal NeovascularizationChoroidal NeovascularizationInjections, IntraocularAlkaliesAngiogenesis InhibitorsNeovascularization, PathologicVascular Endothelial Growth Factor AOphthalmic SolutionsAdministration, TopicalNeovascularization, PhysiologicKeratitisCauteryEye InjuriesDisease Models, AnimalEpithelium, CornealAntigens, CD31Angiogenesis Inducing AgentsSilver NitrateCorneal StromaCorneal TransplantationCorneal OpacityMice, Inbred C57BLVascular Endothelial Growth FactorsEndothelial Growth FactorsLymphokinesConjunctivaKeratitis, HerpeticRabbitsPhotosensitizing AgentsFluorescein AngiographyRetinal VesselsEndothelial CellsFluorescent Antibody Technique, IndirectFibroblast Growth Factor 2Antibodies, Monoclonal, HumanizedPhotochemotherapyMice, Inbred BALB CEndostatinsKeratoplasty, PenetratingThrombospondin 1Endothelium, VascularVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-1Reverse Transcriptase Polymerase Chain ReactionCorneal DiseasesCell MovementIschemiaChoroidPorphyrinsReceptors, Vascular Endothelial Growth FactorBlotting, WesternRetinopathy of PrematurityWound HealingRNA, MessengerDendrimersLaser CoagulationInjections, IntraperitonealVisual AcuityVasa VasorumMice, KnockoutIntravitreal InjectionsEnzyme-Linked Immunosorbent AssayIntercellular Signaling Peptides and ProteinsCells, CulturedHindlimb
Corneal Neovascularization
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Eye Burns
Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.
Burns, Chemical
Sodium Hydroxide
A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)
Cornea
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Retinal Neovascularization
Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
Choroidal Neovascularization
A pathological process consisting of the formation of new blood vessels in the CHOROID.
Injections, Intraocular
The administration of substances into the eye with a hypodermic syringe.
Alkalies
Usually a hydroxide of lithium, sodium, potassium, rubidium or cesium, but also the carbonates of these metals, ammonia, and the amines. (Grant & Hackh's Chemical Dictionary, 5th ed)
Angiogenesis Inhibitors
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Neovascularization, Pathologic
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Ophthalmic Solutions
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Neovascularization, Physiologic
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Keratitis
Inflammation of the cornea.
Cautery
The application of a caustic substance, a hot instrument, an electric current, or other agent to control bleeding while removing or destroying tissue.
Eye Injuries
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Epithelium, Corneal
Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.
Antigens, CD31
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Angiogenesis Inducing Agents
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
Silver Nitrate
A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.
Corneal Stroma
The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
Corneal Transplantation
Partial or total replacement of the CORNEA from one human or animal to another.
Corneal Opacity
Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
Mice, Inbred C57BL
Vascular Endothelial Growth Factors
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
Endothelial Growth Factors
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
Lymphokines
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
Conjunctiva
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Keratitis, Herpetic
A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Photosensitizing Agents
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Fluorescein Angiography
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Retinal Vessels
The blood vessels which supply and drain the RETINA.
Endothelial Cells
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Fluorescent Antibody Technique, Indirect
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Fibroblast Growth Factor 2
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Photochemotherapy
Therapy using oral or topical photosensitizing agents with subsequent exposure to light.
Mice, Inbred BALB C
Endostatins
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
Keratoplasty, Penetrating
Partial or total replacement of all layers of a central portion of the cornea.
Thrombospondin 1
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Endothelium, Vascular
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Vascular Endothelial Growth Factor Receptor-2
A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.
Vascular Endothelial Growth Factor Receptor-1
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Corneal Diseases
Diseases of the cornea.
Cell Movement
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Ischemia
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Choroid
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Receptors, Vascular Endothelial Growth Factor
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Retinopathy of Prematurity
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
Wound Healing
Restoration of integrity to traumatized tissue.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Dendrimers
Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.
Laser Coagulation
The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.
Injections, Intraperitoneal
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Visual Acuity
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Vasa Vasorum
Nutrient blood vessels which supply the walls of large arteries or veins.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Intravitreal Injections
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Hindlimb
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

In vivo significance of ICAM-1--dependent leukocyte adhesion in early corneal angiogenesis. (1/340)

PURPOSE: Numerous investigations have stressed the significance of leukocytes in early angiogenesis. Leukocytes invade the cornea, and the location of their extravasation corresponds to the site of vessel ingrowth. The interactions between leukocytes and vascular endothelium are mediated by various proteins, including adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). In this study, the role of ICAM-1 during early corneal angiogenesis was evaluated in vivo. METHODS: Corneal neovascularization was induced in New Zealand White rabbits by use of intrastromal pellets containing 750 ng vascular endothelial growth factor (VEGF). The fluorescent dye rhodamine 6G was used to stain leukocytes in vivo. Leukocyte adhesion and vessel growth were quantified in vivo by high-resolution fluorescence angiography. To inhibit ICAM-1 interactions a microemulsion containing anti-ICAM-1 antibody was applied topically. RESULTS: Limbal vessels showed increased leukocyte adhesion 24 hours after pellet implantation: The number of rolling and sticking leukocytes was significantly increased compared with the number in control animals (P < 0.01). Treatment with anti-ICAM-1 antibody resulted in reduced leukocyte sticking and increased leukocyte rolling. The area covered by new blood vessels was significantly diminished in eyes treated with anti-ICAM-1 (P < 0.05). CONCLUSIONS: The results support the hypothesis that ICAM-1-mediated leukocyte adhesion is a key event in early angiogenesis. This model may serve for investigation of the significance of adhesion molecules by in vivo observation and quantification.  (+info)

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. (2/340)

Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokinase-activated plasmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease-activated kringles 1-5). K1-5 inhibits endothelial-cell proliferation with a half-maximal concentration of approximately 50 pM. This inhibitory effect is endothelial-cell-specific and appears to be at least approximately 50-fold greater than that of angiostatin. A synergistic efficacy of endothelial inhibition was observed when angiostatin and kringle 5 (K5) were coincubated with capillary endothelial cells. The synergistic effect is comparable to that produced by K1-5 alone. Systemic treatment of mice with K1-5 at a low dose significantly blocked the fibroblast growth factor-induced corneal neovascularization, whereas angiostatin had no effect at the same dose. K1-5 also suppressed angiogenesis in chicken embryos. Systemic administration of K1-5 at a low dose at which angiostatin was ineffective significantly suppressed the growth of a murine T241 fibrosarcoma in mice. The antitumor effect correlates with the reduced neovascularization. These findings suggest that the plasmin-mediated proteolysis may be involved in the negative switch of angiogenesis.  (+info)

Expression of cell adhesion molecules on limbal and neovascular endothelium in corneal inflammatory neovascularization. (3/340)

PURPOSE: To investigate the expression of cell-adhesion molecules on corneolimbal and neovascular endothelium and the associated leukocyte infiltration in an experimental model of inflammatory corneal neovascularization (NV). METHODS: Corneal NV was induced in BALB/c mice by placement of nylon sutures. Interleukin-1 receptor antagonist (IL-1ra) was used topically to determine whether suppression of IL-1 could affect adhesion molecule expression and leukocytic infiltration. At set time points, corneal samples were analyzed immunohistochemically for expression of P-selectin, E-selectin, intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, and platelet- endothelial adhesion molecule (PECAM)-1. Leukocytic infiltration at different time points was quantified histologically. In companion experiments mice deficient in ICAM-1 were investigated to determine the functional relevance of this molecule in corneal leukocyte infiltration. RESULTS: Significant enhanced expression of ICAM-1 was detected on the corneolimbal vascular endothelium as early as 8 hours and on the newly formed corneal NV by day 3, and treatment with IL-1ra led to significant suppression of this expression. IL-1ra-induced suppression of ICAM-1 expression was accompanied by a profound decrease in corneal leukocytic infiltration by 44.6% at day 1 (P < 0.003), 71.8% at day 3 (P < 0.001), 60.1% at day 7 (P < 0.001), and 63.8% at day 14 (P < 0.001), compared with control corneas. Similarly, in ICAM-1 knockout mice, the corneal leukocytic infiltration was 50.3%, 52.9%, and 36.4%, compared with wild-type control animals on day 1 (P < 0.001), day 7 (P < 0.005), and day 14 (P < 0.001), respectively. Expression of PECAM-1 was constitutively present on perilimbal vascular endothelium and had no response to IL-1ra treatment. No significant expression of P-selectin, E-selectin, or VCAM-1 was detected in this experimental model. CONCLUSIONS: These results suggest that leukocytic infiltration in this model of inflammatory corneal NV is closely associated with ICAM-1 expression, and that topical IL-1ra displays corneal anti-inflammatory effects, largely by suppressing ICAM-1 expression on vascular endothelial cells.  (+info)

VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. (4/340)

Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypothesis that VEGF may modulate endothelial progenitor cell (EPC) kinetics for postnatal neovascularization. Indeed, we observed an increase in circulating EPCs following VEGF administration in vivo. VEGF-induced mobilization of bone marrow-derived EPCs resulted in increased differentiated EPCs in vitro and augmented corneal neovascularization in vivo. These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis.  (+info)

Inhibition of rat corneal angiogenesis by 16-kDa prolactin and by endogenous prolactin-like molecules. (5/340)

PURPOSE: The cornea is an avascular organ, where induction of new blood vessels involves the turn-on of proangiogenic factors and/or the turn-off of antiangiogenic regulators. Prolactin (PRL) fragments of 14 kDa and 16 kDa bind to endothelial cell receptors and inhibit angiogenesis. This study was designed to determine whether antiangiogenic PRL-like molecules are involved in cornea avascularity. METHODS: Sixteen-kDa PRL and basic fibroblast growth factor (bFGF) or anti-PRL antibodies were placed into rat cornea micropockets and neovascularization evaluated by the optical density associated with capillaries stained by the peroxidase reaction and by the number of vessels growing into the implants. Prolactin receptors in corneal epithelium were investigated by immunocytochemistry. RESULTS: bFGF induced a dose-dependent stimulation of corneal neovascularization. This effect was inhibited by coadministration of 16-kDa PRL, as indicated by a 65% reduction in vessel density and a 50% decrement in the incidence of angiogenic responses. Corneal angiogenic reactions of different intensities were induced by implantation of polyclonal and monoclonal anti-PRL antibodies. Corneal epithelial cells were labeled by several anti-PRL receptor monoclonal antibodies. CONCLUSIONS: These findings show that exogenous 16-kDa PRL inhibits bFGF-induced corneal neovascularization and suggest that PRL-like molecules with antiangiogenic actions function in the cornea. PRL receptors in the corneal epithelium may imply that PRL in the cornea derives from lacrimal PRL internalized through an intracellular pathway. These observations are consistent with the notion that members of the PRL family are potential regulators of corneal angiogenesis.  (+info)

Nitric oxide synthase-II is expressed in severe corneal alkali burns and inhibits neovascularization. (6/340)

PURPOSE: Inducible nitric oxide synthase (NOS-II) is expressed in many inflammatory conditions. The implication of nitric oxide (NO) in angiogenesis remains controversial. The role of NOS-II and its influence on angiogenesis in corneal neovascularization is unknown and was investigated in this study. METHODS: A mouse model of corneal neovascularization induced by chemical cauterization was used. NOS-II mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction, and NOS-II protein was studied in situ by immunohistochemical analysis of the cornea. The influence of NOS-II on neovascularization was determined by comparison of vessel development in "normal" wild-type mice and mice with a targeted disruption of the NOS-II gene. RESULTS: NOS-II mRNA was induced to very high levels after corneal cauterization and remained upregulated throughout the disease. Migratory cells in the center of the cauterization area expressed NOS-II protein. The neovascular response in mice lacking the NOS-II gene was significantly stronger than in wild-type mice, and the difference increased over time. CONCLUSIONS: These data are the first evidence that NOS-II is expressed in this model of sterile corneal inflammation. NOS-II expression inhibited angiogenesis in severe corneal alkali burns.  (+info)

IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. (7/340)

Few studies have addressed the importance of vascular remodeling in the lung during the development of bleomycin-induced pulmonary fibrosis (BPF). For fibroplasia and deposition of extracellular matrix to occur, there must be a geometric increase in neovascularization. We hypothesized that net angiogenesis during the pathogenesis of fibroplasia and deposition of extracellular matrix during BPF are dependent in part on a relative deficiency of the angiostatic CXC chemokine, IFN-gamma-inducible protein-10 (IP-10). To test this hypothesis, we measured IP-10 by specific ELISA in whole lung homogenates in either bleomycin-treated or control mice and correlated these levels with lung hydroxyproline. We found that lung tissue from mice treated with bleomycin, compared with that from saline-treated controls, demonstrated a decrease in the presence of IP-10 that was correlated to a greater angiogenic response and total lung hydroxyproline content. Systemic administration of IP-10 significantly reduced BPF without any alteration in lung lymphocyte or NK cell populations. This was also paralleled by a reduction in angiogenesis. Furthermore, IP-10 had no direct effect on isolated pulmonary fibroblasts. These results demonstrate that the angiostatic CXC chemokine, IP-10, inhibits fibroplasia and deposition of extracellular matrix by regulating angiogenesis.  (+info)

Effects of 1alpha,25-dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice. (8/340)

PURPOSE: To examine the effects of 1alpha,25-dihydroxyvitamin D3 (1alpha,25[OH]2D3), a hormone that has immunosuppressive properties, on Langerhans cell (LC) migration and corneal neovascularization in mouse corneas. METHODS: Two 10-0 nylon interrupted sutures were placed in the center of 50 BALB/c mouse corneas to induce LC migration and corneal neovascularization. The mice were then randomly assigned to one of five groups. Three groups (n = 11, n = 11, n = 6) received topical 1alpha,25(OH)2D3 (at concentrations of 10(-7) M, 10(-)8 M, 10(-9) M), one group (n = 11) received vehicle only, and one group (n = 11) received no eye drops. Instillation (three times a day) began on the first day after suturing. Corneal neovascularization was assessed by slit lamp microscopy and scored according to the length of newly formed corneal vessels. Fourteen days after suturing, the number of LCs that had migrated into the central corneal epithelium was counted by an immunofluorescence assay using an anti-Ia antibody. RESULTS: The number of LCs in the central cornea was 21.9 +/- 2.8 cells/mm2 in the nontreated group and 17.8 +/- 3.9 cells/mm2 in the vehicle-only group. Significantly fewer LCs were detected in all groups that had received 1alpha,25(OH)2D3 compared with the vehicle only and nontreated groups (10(-7) M: 7.4 +/- 1.2 cells/mm2, 10(-8) M: 7.2 +/- 2.0 cells/mm2, 10(-9) M: 6.2 +/- 0.7 cells/mm2). Moderate inhibition of corneal vascularization was observed in the 10(-7) M 1alpha,25(OH)2D3 group, but not the other groups. CONCLUSIONS: Topical administration of 1alpha,25(OH)2D3 can be effective in suppressing ocular surface inflammation by inhibiting LC migration into mouse corneas.  (+info)

Inhibition of Experimental Corneal Neovascularization by Diclofenac, Ketorolac, and Etanercept | IOVS | ARVO JournalsInhibition of Experimental Corneal Neovascularization by Diclofenac, Ketorolac, and Etanercept | IOVS | ARVO Journals
Purpose: : To evaluate the effect of topically administered diclofenac, ketorolac, and etanercept on experimental corneal neovascularization. Methods: : Chemical cauterization of the cornea in 32 eyes of 32 rats was performed using silver nitrate sticks to induce corneal neovascularization. Topical instillation of diclofenac (Volteran, Novartis Pharmaceuticals), ketorolac (Acular, Allergan), and etanercept (Enbrel, Immunex Corp.) was compared to normal saline treatment for inhibition of neovascularization for 7 days. All animals were treated in accordance with the ARVO guidelines on the care and use of animals in research. The animals were randomly divided in 4 groups. Group 1 (n=8) received balanced salt solution (control), group 2 (n=8) received ketorolac 0.5 %, group 3 (n=8) received diclofenac 0.1%, and group 4 (n=8) received 200 µg/ml of etanercept. Percentage area of cornea covered by neovascularization and scar in each group was calculated separately by use of computer software on ...
http://iovs.arvojournals.org/article.aspx?articleid=2391502
Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions - Tabular View -...Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions - Tabular View -...
The purpose of the study is to test the investigational drug Gamunex-C on the growth of blood vessels over the cornea. This study is being conducted by Dr. Balamurali Ambati at the Moran Eye Center at the University of Utah.. The cornea is the clear outer front part of the eye. In corneal neovascularization, blood vessels grow over the cornea. Corneal neovascularization and ocular anterior segment inflammations are sight-threatening conditions. Lipid deposition and edema with subsequent scar formation can compromise corneal clarity irreversibly. Corneal neovascularization is also a well recognized risk factor for corneal graft failure. In its natural state, the cornea is a site of immune privilege well suited to tissue transplantation. Once vascularized, there is direct exposure of corneal antigens to circulating host immune mechanisms greatly increasing the chance of rejection [Collaborative Corneal Transplantation Study].. Melting or inflammation in the anterior chamber, cornea, or ocular ...
https://clinicaltrials.gov/ct2/show/record/NCT02042027
Corneal neovascularization - WikipediaCorneal neovascularization - Wikipedia
Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into avascular corneal tissue as a result of oxygen deprivation. Maintaining avascularity of the corneal stroma is an important aspect of corneal pathophysiology as it is required for corneal transparency and optimal vision. A decrease in corneal transparency causes visual acuity deterioration. Corneal tissue is avascular in nature and the presence of vascularization, which can be deep or superficial, is always pathologically related. Corneal neovascularization is a sight-threatening condition that can be caused by inflammation related to infection, chemical injury, autoimmune conditions, post-corneal transplantation, and traumatic conditions among other ocular pathologies. Common causes of CNV within the cornea include trachoma, corneal ulcers, phylctenular keratoconjunctivitis, rosacea keratitis, interstitial keratitis, sclerosing keratitis, chemical burns, and wearing contact lenses for ...
https://en.wikipedia.org/wiki/Corneal_neovascularization
DiVA - Search resultDiVA - Search result
Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization.. In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). Among available treatments, anti-VEGF often shows limited or temporary efficacy, while steroids are potentially responsible for many side-effects. This thesis presents a series of linked studies aimed at elucidating the early pathologic changes leading to inflammation and corneal neovascularization, and how various treatments affect this process. In this thesis, anti-inflammatory and anti-angiogenic treatments are applied in corneal neovascularization models, to identify VEGF-independent pathways and other novel factors as future therapy targets, as well as to investigate the endogenous modulation of angiogenesis.. A model of experimental ...
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Review of the Progress in Corneal Neovascularization Animal Models | American Journal of Biochemistry and Biotechnology |...Review of the Progress in Corneal Neovascularization Animal Models | American Journal of Biochemistry and Biotechnology |...
Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.. ...
http://thescipub.com/abstract/10.3844/ajbbsp.2015.221.227
Molecular Vision: Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularizationMolecular Vision: Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization
Due to its noninvasive accessibility and clarity, cornea serves an ideal target for evaluating the efficacy of various treatments against corneal disorders. A multitude of potential gene therapies based on different genes and strategies have been tried in the context of corneal diseases, including corneal NV. For example, various viral-mediated gene delivery systems have been proposed to produce expression of the desired genes with varying expression levels and duration [32-34]. In the case of gene therapy for corneal NV, as in many other situations, it is well recognized that targeting a single gene often fails to ensure the theoretically predicted efficacy [23,35-37]. We therefore investigated the possibility of better management of corneal NV by combining different anti-angiogenic factors in the present study. We showed that the combination of two or three genes exhibited additive effects over a single gene in inhibiting HUVEC proliferation in vitro (Figure 1A). This additive effect, however, ...
http://www.molvis.org/molvis/v16/a37/index.html
Corneal suturing techniques<...
TY - CHAP. T1 - Corneal suturing techniques. AU - Lee, W. Barry. AU - Mannis, Mark J. PY - 2007. Y1 - 2007. N2 - Suturing technique remains one of the most vital skills in the art of contemporary corneal surgery. Although the main purpose of suture placement remains adequate wound apposition and closure, meticulous attention to appropriate suture placement cannot only minimize postoperative astigmatism, but also may facilitate more rapid visual recovery and lead to a more stable wound long term. A variety of factors remain critical for suture placement, including avoidance of mismatch between radial and nonradial suture bite placement, appropriate donor and recipient bite lengths, appropriate bite depth, and symmetrical and adequately dispersed suture tension in each quadrant of the cornea, with special care to prevent excessive tightening. Th e evolution of corneal suturing techniques from overlay sutures to direct appositional suture closure, along with the discovery of small, monofilament ...
https://ucdavis.pure.elsevier.com/en/publications/corneal-suturing-techniques
Therapeutic approaches for corneal neovascularization | Eye and Vision | Full TextTherapeutic approaches for corneal neovascularization | Eye and Vision | Full Text
Anti-VEGF antibodies including off-label bevacizumab (Avastin™, Genentech), ranibizumab (Lucentis™, Genentech), and aflibercept (VEGF Trap-eye (VTE), Eylea) are presently used for the management of various retinal vascular abnormalities [72]. These drugs are different in their pharmacokinetics, structure, and molecular weight. Ranibizumab and aflibercept, which received Food and Drug Administration (FDA) approval for the treatment of neovascular age-related macular degeneration, were designed specifically for intravitreal injection.. Bevacizumab is a full-length humanized murine monoclonal IgG1 antibody with a molecular weight of 149 kDa that received FDA approval for the management of different cancers. 93% and 7% of amino acid sequences of this drug are similar to the human IgG1 and murine antibody, respectively [73]. Bevacizumab recognizes all isoforms of VEGF-A. Despite being off-label, it is used commonly as an intravitreal injection for the management of various retinal diseases [74]. ...
https://eandv.biomedcentral.com/articles/10.1186/s40662-017-0094-6
Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization | IOVS | ARVO JournalsDown-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization | IOVS | ARVO Journals
MicroRNA-184 down-regulated the levels of VEGF and β-catenin of HCE cells. Western blotting was performed to detect protein levels of VEGF and β-catenin in the transfected HCE cells. (A) Representative images of Western blotting of VEGF in the HCE cells transfected with scramble or the mimic of miR-184 for 48 hours. (B) Statistical analysis of Western blotting data of VEGF of the HCE cells transfected with scramble or the mimic of miR-184 for 48 hours. (Data are presented as mean ± SEM, n = 3 in each group, **P , 0.01.) (C) Representative images of Western blotting of VEGF in the HCE cells transfected with scramble or the inhibitor of miR-184 for 48 hours. (D) Statistical analysis of Western blotting data of VEGF of the HCE cells transfected with scramble or the inhibitor of miR-184 for 48 hours. (Data are presented as mean ± SEM, n = 3 in each group, ***P , 0.001.) (E) Representative images of Western blotting of β-catenin in the HCE cells transfected with scramble or the mimic of miR-184 ...
http://iovs.arvojournals.org/article.aspx?articleid=2506767
Topical IL-1-Ra for Treatment of Corneal Neovascularization - Study Results - ClinicalTrials.govTopical IL-1-Ra for Treatment of Corneal Neovascularization - Study Results - ClinicalTrials.gov
10 patients will complete a course of treatment with placebo, followed by a course of treatment with 5% custom made topical IL-1Ra.. IL-1Ra : 5% custom made topical IL-1Ra 3 times a day in both eyes for a period of 6 weeks. Placebo : Custom eye drop eye three times a day in both eyes for a period of 6 weeks. ...
https://clinicaltrials.gov/ct2/show/results/NCT00915590
Gene Signal : GS-101 (Aganirsen) Clinical Trials
Gene Signal is currently developing aganirsen GS-101 (an antisense oligonucleotide or short naturally occurring DNA strand). GS-101 is a topical medication in the form of eye drops, and is currently being researched for the management of excessive vascular growth in the cornea, also known as neovascularisation GS-101 is a copy of a naturally occurring human gene and acts by inhibiting the expression of IRS-1, a protein required for the formation and growth of new blood vessels. By blocking the expression of this protein in pro-angiogenic conditions (in this case, those with excessive vascular growth), GS-101 inhibits and regresses corneal neovascularisation, which interferes with vision and may be the cause of graft rejection. Phase I, Phase II and Phase III clinical studies have been completed for Gene Signal s GS-101 in the management of Corneal Graft Rejection associated with Neovascularisation (excessive vascular growth of the cornea). The Phase I trial evaluated the safety of GS-101 is ...
http://genesignal.com/GS-101_Aganirsen_Clinical_Tr.32.0.html?&cHash=8ee942bfae99e7d35985056239e7d3e1&print=1
DiVA - SökresultatDiVA - Sökresultat
Inflammatory angiogenesis is the pathogenic mechanism of various sight-threatening eye diseases, among them corneal neovascularization. Current treatment options include steroids which have undesirable side effects, or anti-VEGF which has only limited efficacy. In an inflammatory environment, however, angiogenesis can be stimulated by numerous factors not directly targeted by anti-VEGF therapy. The aim of this study was to induce corneal inflammation leading to angiogenesis, and investigate the early, differential effects of steroid and anti-VEGF therapy at the cellular, tissue, and gene expression levels. Fifty-two Wistar rats received a single intrastromal corneal suture to induce a controlled inflammatory angiogenic response. Rats were subsequently treated with dexamethasone, rat specific anti-VEGF, or goat IgG (control), topically 4 times daily for 7 days. In vivo confocal microscopy of the cornea was performed longitudinally from 5 h up to 7 d to investigate morphology at the cellular and ...
http://liu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22beabo84%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=sv&query=
OXB-202 | OxfordBioMedicaOXB-202 | OxfordBioMedica
OXB-202Gene-based treatment for corneal graft rejectionStatus: Phase I/II study in preparationCorneal graft rejectionCornea grafts are one of the most successful tissue transplants, but over time a significant number are rejected due to corneal neovascularisation. Currently, approximately 100,000 transplants are performed each year, but with this representing only 1% of those requiring treatment the number is predicted to increase substantially. Our approach
http://www.oxfordbiomedica.co.uk/node/266
Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface...Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface...
Results Autologous cultivated oral mucosal epithelial sheets were successfully generated for all 17 patients. All patients were followed up for more than 36 months; the mean follow-up period was 55 months and the longest follow-up period was 90 months. During the long-term follow-up period, postoperative conjunctivalisation and symblepharon were significantly inhibited. All eyes manifested various degrees of postoperative corneal neovascularisation, but it gradually abated and its activity was stable at 6 months after surgery. Best-corrected visual acuity was improved in 18 eyes (95%) during the follow-up periods, and visual acuity at the postoperative 36th month was improved in 10 eyes (53%). ...
http://bjo.bmj.com/content/early/2010/11/19/bjo.2010.188714
Omega Research
RESULTS: The receptors for LXA4, ALX/Fpr-rs-2 and for RvE1, ChemR23 were each expressed by epithelium, stromal keratocytes, and infiltrated CD11b(+) cells in corneas. Compared to the vehicle-treated eye, ATLa-, RvD1-, and RvE1-treated eyes had reduced numbers of infiltrating neutrophils and macrophages and reduced mRNA expression levels of TNF-alpha, IL-1 alpha, IL-1 beta, VEGF-A, VEGF-C, and VEGFR2. Animals treated with these mediators had significantly suppressed suture-induced or IL-1 beta-induced hemangiogenesis (HA) but not lymphangiogenesis. Interestingly, only the application of ATLa significantly suppressed VEGF-A-induced HA ...
http://omega-research.com/researchview.php?ID=1799&catid=5
contacts | Cougar Health Services | Washington State Universitycontacts | Cougar Health Services | Washington State University
Imagine its late, youre really tired and you just want to sleep. You might be tempted to skip removing your contacts and head straight to bed.. But before you climb under the covers, its really important that you take your contacts out. Sleeping in contacts can compromise the health of your eyes. More specifically, heres what can happen:. Your eyes can be deprived of oxygen. Your cornea, the part of your eye you place a contact on top of, needs oxygen from the air. Wearing contacts blocks oxygen from getting to your cornea. This only gets worse when your eyes are closed during sleep.. New blood vessels may start to form on corneas that arent getting enough oxygen. This condition, called corneal neovascularization, can cause a permanent reduction in vision, blurry vison or eye infections. The resulting damage can prevent you from wearing contact lenses or being a candidate for LASIK surgery in the future.. You could get a bacterial infection. Sleeping in contacts increases your risk of ...
https://cougarhealth.wsu.edu/tag/contacts/
Department of Transplantation Immunology - Ústav experimentální medicíny AV ČR, v. v. i.Department of Transplantation Immunology - Ústav experimentální medicíny AV ČR, v. v. i.
2016. Ardan, T., Němcová, L., Bohuslavová, B., Klezlová, A., Popelka, Š., Studenovská, H.3, Hrnčiarová, E., Čejková, J., Motlík, J.: (2016) Reduced Levels of Tissue Inhibitors of Metalloproteinases (TIMPs) in UVB Irradiated Corneal Epithelium. Photochem. Photobiol., IN PRESS IF 2.008. Bílková, B., Albrecht, T., Chudičková, M., Holáň, V., Piálek, J., Vinkler, M.: (2016) Application of Concanavalin A during immune responsiveness skin-swelling tests facilitates measurement interpretation in mammalian ecology. Ecology and Evolution, 6 (13): 4551-4564. IF 2.537. Čejka, Č., Čejková, J., Trošan, P., Zajícová, A., Syková, E., Holáň, V.: (2016) Transfer of mesenchymal stem cells and cyclosporine A on alkali-injured rabbit cornea using nanofiber scaffolds strongly reduces corneal neovascularization and scar formation. Histol. Histopath., 31: 969-980. IF 1.875. Čejka, Č., Holáň, V., Trošan, P., Zajicová, A., Javorková E., Čejková, J.: (2016) The Favorable Effect of ...
http://old.iem.cas.cz/en/research/departments/Transplantation-Immunology/
Metalloproteinase Expression in Corneal Wounds - Dimitri AzarMetalloproteinase Expression in Corneal Wounds - Dimitri Azar
Corneal neovascularization (NV) is a major cause of blindness worldwide. Our research objective is to identify the role of membrane type 1 matrix metalloprotein...
https://grantome.com/grant/NIH/R01-EY010101-18
92070 in post op period92070 in post op period
Patient had surgery and returns complaining of FB sensation due to suture placement. Physician gave pt. bangage contact lens to alleviate FB sensation
https://www.aapc.com/memberarea/forums/56699-92070-post-op-period.html
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ZF North America Merchandise - Official MerchandiseZF North America Merchandise - Official Merchandise
Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our privacy policy.. ...
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Corneal Fine Needle Diathermy With Adjuvant Bevacizumab to Treat Corneal Neovascularization in Children. - Semantic ScholarCorneal Fine Needle Diathermy With Adjuvant Bevacizumab to Treat Corneal Neovascularization in Children. - Semantic Scholar
PURPOSE To report the outcomes of corneal fine needle diathermy (FND) with adjuvant intrastromal and subconjunctival bevacizumab injection for corneal neovascularization (CN) in children. METHODS Medical records of all children who had undergone FND with adjuvant bevacizumab injection were reviewed retrospectively. Treatment efficacy was evaluated by changes in visual acuity, regression of CN, and clearing of lipid deposits with the aid of slit-lamp color images that were taken before surgical intervention and at last follow-up visit. Postoperative complications were recorded and served to assess the safety of the procedure. RESULTS Nine eyes of 9 patients were included in the study. The mean age of the patients was 8.4 ± 4.2 years (4-15 years) and the mean follow-up time was 18.7 ± 12.2 months (5-35 months). Three eyes had a history of herpes simplex keratitis (HSK), 3 eyes had complete corneal anesthesia, 2 eyes had CN following suture tract infection after corneal transplant for HSK scar and
https://www.semanticscholar.org/paper/Corneal-Fine-Needle-Diathermy-With-Adjuvant-Bevaci-Elbaz-Mireskandari/07c8ec0cc840cd959188a6c1ca07c8188f1e2cc0
Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization<...Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization<...
TY - JOUR. T1 - Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization. AU - Romano, Vito. AU - Steger, Bernhard. AU - Brunner, Matthias. AU - Ahmad, Sajjad. AU - Willoughby, Colin. AU - Kaye, Stephen B.. PY - 2016/3/9. Y1 - 2016/3/9. N2 - PURPOSE:To describe a method to assess corneal neovascular (CoNV) complexes and identify feeder vessels for selective arterial fine-needle diathermy (FND).METHODS:In patients with CoNV, color photography and corneal indocyanine green angiography (ICGA) and fluorescein angiography are performed. After injection of indocyanine green and sodium fluorescein dye, videography and single-frame images of the region of interest are recorded. Videography is used to measure the time to leakage to assess vessel maturity to guide medical treatment and to discern afferent from efferent vessels. Single-frame images are then selected to locate the number of afferent vessels for surgery, which are selectively cut with a 25-gauge ...
https://pure.ulster.ac.uk/en/publications/method-for-angiographically-guided-fine-needle-diathermy-in-the-t
Corneal angiogenesis assay of wt and c-abl-deficient | Open-iCorneal angiogenesis assay of wt and c-abl-deficient | Open-i
Corneal angiogenesis assay of wt and c-abl-deficient mice. VEGF-saturated or PBS sham Hydron pellets were implanted in corneas of 3-wk-old mice and 7 d postim
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2193304_JEM001496.f5&req=4
ESCRS | European Society of Cataract & Refractive SurgeonsESCRS | European Society of Cataract & Refractive Surgeons
10 patients with severe corneal neovascularisation (5 after corneal transplant and 5 after infectious keratitis). Injection of Avastin at a dose of 1,25 mg was given subconjunctivally. Patiens were followed-up for 4 weeks, if inhibition result was unsatisfactory injection was repeated ...
http://www.escrs.org/amsterdam2013/programme/posters-details.asp?id=19248
Aganirsen eye drops safe, well tolerated in patients with keratitisAganirsen eye drops safe, well tolerated in patients with keratitis
Aganirsen eye drops demonstrated significant benefits among patients with keratitis, as well as in patients with viral keratitis and central neovascularization, according to the results of a recent study. The multicenter, double-masked, phase 3 study included 69 patients with keratitis-related progressive corneal neovascularization who were randomized to use either aganirsen drops (86
https://www.healio.com/news/ophthalmology/20140708/aganirsen-eye-drops-safe-well-tolerated-in-patients-with-keratitis
Official ESCRS | European Society of Cataract & Refractive SurgeonsOfficial ESCRS | European Society of Cataract & Refractive Surgeons
This is our initial experience with FND represented in only 2 cases, therefore definitive conclusions couldnt be established. Nevertheless, based on our results and after reviewing the two largest series published since FND was described, we found this technique simple, inexpensive and effective in occluding established corneal vessels, the main recognized risk factor for corneal graft rejection and failure. The lack of any major intra and postoperative complications reinforces the safety profile of the procedure. FND can be repeated and performed in any small eye unit around the world, as it does not require specialized equipment ...
http://www.escrs.org/lisbon2017/programme/poster-village-details.asp?id=28461&day=0
Therapy for Ocular Angiogenesis: Principles and Practice
Therapy for Ocular Angiogenesis: Principles and Practice covers the basic pathophysiology of ocular angiogenesis and strategies for inhibition.
http://hp.healthjobsplus.com/site/catalog/books/8593.jsp
Salmon Saturday Afternoon: Salmon with Pesto and Pasta<...Salmon Saturday Afternoon: Salmon with Pesto and Pasta<...
Salmon Saturday: Because there are so many great ways to prepare salmon and someone has to start writing them down. Take these ideas and make them your own. Its about 6:30am on Saturday morning and I have no Salmon Saturdays ready to launch. I have ideas of what I could write, but nothing really inspired…
https://smplefy.wordpress.com/2012/08/18/salmon-saturday-afternoon-salmon-with-pesto-and-pasta/
Gene Signal : News on GS-101 (Aganirsen)
The I-CAN study was the first randomised trial of a topical inhibitor of corneal angiogenesis. It showed that topical applications of aganirsen are safe and well-tolerated, that it significantly reduces the relative area of corneal neovascularisation, and that the need for corneal transplantation is reduced in patients suffering from viral keratitis and central neovascularization About neovascularisation and Corneal Grafts The following Orphan Drug designations were granted to Gene Signal for GS 101 - antisense oligonucleotide: On November 7, 2016, the US Food and Drug Administration granted aganirsen an Orphan Drug Designation for Prevention of Corneal Graft Rejection. On 11 June 2014, Orphan designation (EU/3/14/1275) was granted by the European Commission to Gene Signal for aganirsen (GS-101) for the treatment of Central Retinal Vein Occlusion, the most common cause of Neovascular Glaucoma. On April 17, 2007, Orphan designation (EU/3/07/445) was granted by the European Commission to Gene ...
http://genesignal.com/News_on_GS-101_Aganirsen.23.0.html?cHash=8ee942bfae99e7d35985056239e7d3e1&print=1
Copper transport protein and inflammatory angiogenesis - Augusta University Research Profiles
DESCRIPTION (provided by applicant): The overall aim of this grant is to elucidate the novel linkage between copper transport protein Antioxidant1 (Atox1) and NADPH oxidase involved in inflammatory angiogenesis. Ischemic disease is a leading cause of morbidity and mortality in worldwide. Neovascularization is an important repair process in response to ischemia, which depends on angiogenesis, inflammation and reactive oxygen species (ROS). Copper (Cu), an essential micronutrient, is involved in physiological repair processes such as wound healing and angiogenesis as well as in various pathophysiologies including tumor growth, atherosclerosis and inflammatory diseases. Since excess Cu is toxic, bioavailability of intracellular Cu is tightly controlled by Cu transport proteins such as Cu chaperone Atox1. Our laboratories provided the first evidence that Atox1 functions as a Cu-dependent transcription factor to regulate Cu-induced cell growth. Furthermore, we are one of the first to demonstrate that ...
https://augusta.pure.elsevier.com/en/projects/copper-transport-protein-and-inflammatory-angiogenesis
ORBi: Browsing ORBiORBi: Browsing ORBi
Poster (2011, October). Cornea engraftment is the most common organ transplantation practiced around the world. The cornea is totally devoid of blood or lymphatic vessels, except in a peripheral zone called the limbus. This ... [more ▼]. Cornea engraftment is the most common organ transplantation practiced around the world. The cornea is totally devoid of blood or lymphatic vessels, except in a peripheral zone called the limbus. This property, named corneal angiogenic privilege, is conserved among all mammals to maintain cornea transparency and optimal visual acuity. In pathological conditions such as trauma, infections or hypoxia, blood and lymphatic vessels can grow into the avascular cornea, reducing visual acuity. In case of keratoplasty, it also considerably increases the risk of cornea graft rejection and is so considered as a high-risk keratoplasty. Treatments improving cornea survival after transplantation need to be developed, notably aiming at blocking corneal neovascularization. ...
https://orbi.uliege.be/browse?type=author&value=Paupert%2C+Jenny+p079446
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. | JEMInhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. | JEM
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. ...
http://jem.rupress.org/content/179/5/1409
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Hazards of redundant corneal sutures: A safety message : Journal of Cataract & Refractive SurgeryHazards of redundant corneal sutures: A safety message : Journal of Cataract & Refractive Surgery
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https://journals.lww.com/jcrs/Citation/2004/06000/Hazards_of_redundant_corneal_sutures__A_safety.4.aspx
Molecular Images of Neovascularization | CirculationMolecular Images of Neovascularization | Circulation
A question that has been raised in deliberations over why angiogenesis trials in humans have not demonstrated the robust therapeutic effects seen in earlier animal studies is whether the end points chosen for these trials were correct; ie, what is the definition of successful therapeutic neovascularization? Furthermore, were the measurement tools that were used to capture such end points adequately sensitive to detect them, even if they were present? Most scientists and clinicians would agree that successful neovascularization requires that new blood vessels be functional, supply the ischemic region with blood, and be stable over time. Our patients would emphasize that irrespective of whether the treatment makes them live longer, they would like to feel better, and hence quality of life is an important end point. Here, we consider whether the identification of molecular markers of neovascularization adds useful information and/or should be incorporated into the definition of successful ...
http://circ.ahajournals.org/content/111/24/3188
Annexin - The proteasome: structure, function, and role in the cellAnnexin - The proteasome: structure, function, and role in the cell
TRY TO evaluate whether trapping vascular endothelial development element A (VEGF-A) would suppress angiogenesis and inflammation in dried out eye corneas inside a murine corneal suture magic size. buffered saline PBS). Corneas were harvested and immunohistochemical staining was performed to review the extents of Compact disc11b+ and neovascularization cell infiltration. Real-time polymerase string response was … Continue reading TRY TO evaluate whether trapping vascular endothelial development element A (VEGF-A). ...
http://www.globaltechbiz.com/category/annexin/
physiologic neovascularization
Publications, Research Grants, Scientific Experts, Research Topics, Species, Genomes and Genes about physiologic neovascularization
https://www.labome.org/topics/physical/natural/biological/circulatory/cardiovascular/cardiovascular/physiologic-neovascularization-20039.html
Phenotypical signature of pro-angiogenic TEM.(A) In viv | Open-iPhenotypical signature of pro-angiogenic TEM.(A) In viv | Open-i
Phenotypical signature of pro-angiogenic TEM.(A) In vivo corneal vascularization assay to assess the pro-angiogenic activity of TEM isolated from peripheral blo
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4359163_pcbi.1004050.g001&req=4
GcMAF trial | Phoenix Rising ME / CFS ForumsGcMAF trial | Phoenix Rising ME / CFS Forums
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http://forums.phoenixrising.me/index.php?threads/gcmaf-trial.24621/
What is GcMAF & Can it Help Fight Cancer? (video)What is GcMAF & Can it Help Fight Cancer? (video)
Its been researched in relation to cancer, autism, and Alzheimers, but just what is GcMAF and how does it work? Dr. Connealy explains.
https://thetruthaboutcancer.com/gcmaf-can-help-fight-cancer-video/
A Drug Delivery System for Administration of Anti-TNF-α Antibody | TVST | ARVO JournalsA Drug Delivery System for Administration of Anti-TNF-α Antibody | TVST | ARVO Journals
A limitation to the use of biologic therapies is the risk of significant systemic adverse events. Local administration achieves lower systemic exposure to the drug and therefore is likely associated with lower rates of severe adverse events. The use of infliximab eye drops has been investigated as an alternative modality for local drug delivery. The administration of topical infliximab eye drops reduced corneal opacity, perforation, and eyelid fibrosis in a mouse model of corneal alkali burn,19 and improved tear volume, corneal surface regularity, and goblet cell density in a mouse model of dry eye.20 In rabbit models, the use of topical infliximab prevented corneal neovascularization21 and suppressed subconjunctival wound healing after trabeculectomy.22 On the other hand, cerebrovascular accidents are recognized complications of systemic anti-VEGF therapy23 while anti-TNF-α agents are associated with a risk of opportunistic infections, malignancies, infusion reactions, as well as cardiac and ...
http://tvst.arvojournals.org/article.aspx?articleid=2503071
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Rarely, patients with right-to-left shunting and subsequent transfusion requirementsas well as for sub viagra fetal tissue or by temporary derangements and treatment of children with hib meningitis. , answers i. Severe corneal neovascularization, which is the most common intraocular tumor in the low-risk summer season when aom is to help identify this event as a dynamic process presenting as vascular ring or orifice. Neonatal infections bacterial & spirochetal proteinuria, cylindruria, and minimal pi is normal. The spinous processes associated with clinical symptoms and signs achalasia is uncommon but include benign juvenile myoclonic epilepsy of childhood usually lead to fur-ther progression of long-term chronic transfusion therapy, however, and patients are not useful in pressure-controlled modes of mechanical ventilation a propen-sity analysis. Earlier postnatal ultrasound might underestimate the degree of organ involvement, neutropenia or thrombocytopenia associated with fat malabsorption ...
http://www.pmhccares.org/?ger=sub-for-viagra&as=5
Angiogenic factor: A possible mechanism for neovascularization produced by omental pedicles<...
TY - JOUR. T1 - Angiogenic factor. T2 - A possible mechanism for neovascularization produced by omental pedicles. AU - Cartier, R.. AU - Brunette, I.. AU - Hashimoto, K.. AU - Bourne, W. M.. AU - Schaff, Hartzell V. PY - 1990. Y1 - 1990. N2 - To determine possible mechanisms by which omental pedicles protect bronchial anastomoses from ischemia, we studied the angiogenic potential of a lipid extract of omentum. A rabbit cornea model was used to quantify neovascularization produced by methanol-chloroform extract of homogenized autologous omentum or perirenal fat. In 22 anesthetized rabbits, 10 μl of omental lipid extract was injected into the cornea. In each animal the opposite eye was used as a control and was injected with a similar volume of extract prepared from perirenal fat. The side of injection of autologous omental fat was randomized and was not known to the investigator who assessed neovascularization on days 4, 7, 14, and 21 after injection. Neovascularization was recorded on ...
https://mayoclinic.pure.elsevier.com/en/publications/angiogenic-factor-a-possible-mechanism-for-neovascularization-pro
CATARACT EXTRACTION WITH CORNEAL SUTURE | JAMA | JAMA NetworkCATARACT EXTRACTION WITH CORNEAL SUTURE | JAMA | JAMA Network
From time to time ophthalmic surgeons have tried to find some satisfactory means of closing the corneal wound after cataract extraction by mechanical means. Bri
https://jamanetwork.com/journals/jama/article-abstract/432636
The fibroblast and (myo)fibroblast in inflammatory angiogenesis - Université de Limoges
Normal wound healing includes a number of overlapping phases. After injury, there is an early inflammatory step characterised by haemorrhage and clotting. At this time, the wound has a provisional serum-derived extracellular matrix, which serves to seal the wound temporarily and allows the invasion of cells that carry out the repair process. In the next phase, consisting of granulation tissue development, fibroblasts invade the wound and commence replacing the provisional matrix with a more mature wound matrix. The fibroblasts present during the early granulation tissue phase resemble immature fibroblasts with a highly synthetic appearance. However, as the granulation tissue phase proceeds, fibroblasts start showing a new phenotype with prominent contractile structures represented by microfilament bundles or stress fibres; these structures express contractile proteins typical of smooth muscle cells, particularly of vascular smooth muscle cells, such as α-smooth muscle actin [1]. Recently, it has been
https://hal-unilim.archives-ouvertes.fr/hal-00661048
NAVER Academic | The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization.NAVER Academic | The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization.
Raquel Lima e Silva, Jikui Shen, Sean F Hackett, Shu Kachi, Hideo Akiyama, Katsuji Kiuchi, Katsutoshi Yokoi, Maria C Hatara, Thomas Lauer, Sadia Aslam, Yuan Yuan Gong, Wei-Hong Xiao, Naw Htee Khu, Catherine Thut, Peter A Campochiaro
http://academic.naver.com/article.naver?doc_id=146500558
In our examine, the diploma of inflammation and neovascularization have been equivalent among CBAV-AS and TAV-AS |...
These findings recommend that an inappropriate fibrotic reaction to persistent inflammation and neovascularization, particularly on the aortic facet, may lead
http://www.pi4kinhibitor.com/2016/08/17/in-our-examine-the-diploma-of-inflammation-and-neovascularization-have-been-equivalent-among-cbav-as-and-tav-as/
Tests of Second Generation GcMAFTests of Second Generation GcMAF
In vitro experiments conducted by Saisei Mirai indicate increased rate of maturation of dendritic cells (DCs), a type of immune cell, with 2nd Generation GcMAF. This graph shows specific marker expression of dendritic cells grown from normal peripheral blood with and without 2nd Generation GcMAF after 6 and 8 days cultivation. From this preliminary experiment we observed that 2nd Generation GcMAF increases the rate of maturation of dendritic cells. The ability of dendritic cells to regulate immunity is dependent on DC maturation. The process of DC maturation, results in an increase in the surface expression of costimulatory molecules, morphological changes (such as formation of dendrites), secretion of chemokines, cytokines and proteases, and surface expression of adhesion molecules and chemokine receptors ...
https://www.saisei-mirai.or.jp/en/macrophage_gcmaf_tests_eng/
Could GcMAF be a cure for cancerCould GcMAF be a cure for cancer
GcMAF is a natural, immune stimulating protein in all healthy people. But, cancer patients need to learn about a degrading enzyme that inhibits GcMAF.
https://www.naturalhealth365.com/gcmaf_protein.html/
Corneal neovascularizationCorneal neovascularization
... (CNV) is the in-growth of new blood vessels from the pericorneal plexus into avascular corneal ... If the cornea is inflamed via corneal neovascularization, the suppression of enzymes can block CNV by compromising with corneal ... Maintaining avascularity of the corneal stroma is an important aspect of corneal pathophysiology as it is required for corneal ... Corneal neovascularization has become more common worldwide with an estimated incidence rate of 1.4 million cases per year, ...
https://en.wikipedia.org/wiki/Corneal_neovascularization
NeovascularizationNeovascularization
Choroidal neovascularization Corneal neovascularization Revascularization Rubeosis iridis Inosculation Neely, Kimberly A.; ... Corneal neovascularization is a condition where new blood vessels invade into the cornea from the limbus. It is triggered when ... Neovascularization in the eye can cause a type of glaucoma (neovascularization glaucoma) if the new blood vessels' bulk blocks ... "Treatment of Corneal Neovascularization". EyeNet Magazine. American Academy of Ophthalmology: 35-6. Retrieved 14 July 2020. ...
https://en.wikipedia.org/wiki/Neovascularization
Pericorneal plexusPericorneal plexus
"Corneal Neovascularization: An Anti-VEGF Therapy Review". Survey of Ophthalmology. 57 (5): 415-429. Retrieved 2022-11-26. v t e ...
https://en.wikipedia.org/wiki/Pericorneal_plexus
Tyrosine phosphorylationTyrosine phosphorylation
Hayashi A, Popovich KS, Kim HC, de Juan E (1997). "Role of protein tyrosine phosphorylation in rat corneal neovascularization ...
https://en.wikipedia.org/wiki/Tyrosine_phosphorylation
LanepitantLanepitant
... such as corneal neovascularization. "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended ... "NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 ( ...
https://en.wikipedia.org/wiki/Lanepitant
BefetupitantBefetupitant
"NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 ( ... has however continued to be researched for other possible applications such as treatment of corneal neovascularization. ...
https://en.wikipedia.org/wiki/Befetupitant
Hutchinsons patchHutchinson's patch
The sign is an indication of interstitial (or parenchymatous) keratitis, causing corneal neovascularisation. Blood vessels ...
https://en.wikipedia.org/wiki/Hutchinson's_patch
PemphigoidPemphigoid
Besides, reduced tearing with erosion and neovascularization of the cornea leads to corneal opacification and perforation. ...
https://en.wikipedia.org/wiki/Pemphigoid
Mustard gasMustard gas
... and neovascularization. In these severe and infrequent cases, corneal transplantation has been used as a treatment option. ... Extreme ocular exposure to mustard gas vapors may result in corneal ulceration, anterior chamber scarring, ...
https://en.wikipedia.org/wiki/Mustard_gas
Prostaglandin EP4 receptorProstaglandin EP4 receptor
This result suggests that EP4 activation contributes to corneal neovascularization and that EP4 antagonists may be useful for ... A selective EP4 antagonists significantly reduced corneal neovascularization in rats caused by oxygen-induced retinopathy or ... corneal endothelium, corneal keratocytes, trabecular cells, ciliary epithelium, conjunctival stromal cells, and iridal stromal ...
https://en.wikipedia.org/wiki/Prostaglandin_EP4_receptor
BlepharitisBlepharitis
... corneal neovascularization, and ulceration. Patients with an inflammatory eyelid lesion that appears suspicious of malignancy ... This serves as a primary indication of regional dryness in the pre-corneal tear film after fluorescein injections. If TBUT is ... Other signs may include telangiectasia on the anterior eyelid, collarettes encircling the lash base, and corneal changes. ... and corneal ulcer or irritation. The lids may become red and may have ulcerate, non-healing areas that may lead to bleeding. ...
https://en.wikipedia.org/wiki/Blepharitis
LASIKLASIK
... sometimes resulting in corneal neovascularization-the growth of blood vessels into the cornea. This causes a slight lengthening ... Both the depth of the corneal incisions and the degree of central corneal flattening correlated with the laser energy applied. ... Those with Fuchs' corneal endothelial dystrophy, corneal epithelial basement membrane dystrophy, retinal tears, autoimmune ... are made of materials with greater oxygen permeability that help reduce the risk of corneal neovascularization, patients ...
https://en.wikipedia.org/wiki/LASIK
Eye diseaseEye disease
Corneal neovascularization (H18.5) Fuchs' dystrophy - cloudy morning vision (H18.6) Keratoconus - degenerative disease: the ... Corneal ulcer / Corneal abrasion - loss of the surface epithelial layer of the eye's cornea (H16.1) Snow blindness / Arc eye - ... a rare congenital eye condition leading to underdevelopment or even absence of the iris of the eye Endophthalmitis Corneal ...
https://en.wikipedia.org/wiki/Eye_disease
List of ICD-9 codes 320-389: diseases of the nervous system and sense organsList of ICD-9 codes 320-389: diseases of the nervous system and sense organs
Interstitial and deep keratitis 370.6 Corneal neovascularization 370.8 Other forms of keratitis 370.9 Unspecified 371 Corneal ... cornea 371.0 Corneal scars and opacities 371.1 Corneal pigmentations and deposits 371.2 Corneal oedema 371.3 Changes of corneal ... membranes 371.4 Corneal degenerations 371.5 Hereditary corneal dystrophies 371.6 Keratoconus 371.7 Other corneal deformities ... one eye 369.9 Unspecified visual loss 370 Keratitis 370.0 Corneal ulcer 370.1* Dendritic keratitis (054.4†) 370.2 Other ...
https://en.wikipedia.org/wiki/List_of_ICD-9_codes_320–389:_diseases_of_the_nervous_system_and_sense_organs
Ribonucleotide reductaseRibonucleotide reductase
In mice models of stromal keratitis and corneal neovascularization (HSV ocular disease), a small RNR2 C-terminal analog BILD ...
https://en.wikipedia.org/wiki/Ribonucleotide_reductase
AganirsenAganirsen
Phase III in progressive corneal neovascularisation in patients with infectious keratitis and on the waiting list for Corneal ... including progressive corneal neovascularization in patients with infectious keratitis and wet age related macular degeneration ... "GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial" ... "Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for ...
https://en.wikipedia.org/wiki/Aganirsen
List of MeSH codes (C11)List of MeSH codes (C11)
... corneal edema MeSH C11.204.290 - corneal neovascularization MeSH C11.204.299 - corneal opacity MeSH C11.204.299.070 - arcus ... corneal ulcer MeSH C11.294.354 - eye infections, bacterial MeSH C11.294.354.220 - conjunctivitis, bacterial MeSH C11.294. ... corneal dystrophies, hereditary MeSH C11.270.162.438 - Fuchs' endothelial dystrophy MeSH C11.270.235 - duane retraction ... retinal neovascularization MeSH C11.768.740 - retinal perforations MeSH C11.768.757 - retinal vasculitis MeSH C11.768.760 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C11)
Chi Hwan LeeChi Hwan Lee
... such as corneal neovascularization, in a rabbit model without showing a noticeable side effect over current standard therapies ... All-printed corneal electrodes on soft contact lenses for noninvasive recording of human electroretinogram, Nature ...
https://en.wikipedia.org/wiki/Chi_Hwan_Lee
CYR61CYR61
... has potent angiogenic activity upon endothelial cells and induces neovascularization, first demonstrated in a corneal ... enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic ...
https://en.wikipedia.org/wiki/CYR61
Rubeosis iridisRubeosis iridis
... choroidal neovascularization) CNV (corneal neovascularization) NVD (neovascularization of the disc) "rubeosis iridis" at ... Once the neovascularization has been longstanding, the new vessels recruit fibrous tissue, and as this forms and contracts, the ... Rubeosis iridis is a medical condition of the iris of the eye in which new abnormal blood vessels (formed by neovascularization ... If caught early, the neovascularization can be reversed with prompt panretinal photocoagulation (PRP), or injection of anti- ...
https://en.wikipedia.org/wiki/Rubeosis_iridis
List of contact lens complicationsList of contact lens complications
Corneal epithelial infiltrates Keratitis Corneal ulcer Corneal stroma Corneal neovascularisation Corneal oedema Corneal ... Ptosis Giant papillary conjunctivitis Superior limbic keratoconjunctivitis Epithelium Corneal abrasion Corneal erosion Contact ... infiltrates Corneal endothelium Endothelial polymegathism Effects of long-term contact lens wear on the cornea (Articles ...
https://en.wikipedia.org/wiki/List_of_contact_lens_complications
Ocular immune systemOcular immune system
... but also neovascularization (formation of new blood vessels), which can lead to a loss of corneal transparency. Therefore, the ... Corneal nerves serve as a form of defense by detecting the presence of foreign bodies on the corneal surface. This leads to ... Corneal epithelial cells present a physical barrier to prevent microbes from reaching the interior of the eye chamber, which is ... Tears bathe corneal epithelial cells in a moist environment, preventing them from drying out and weakening. However, the liquid ...
https://en.wikipedia.org/wiki/Ocular_immune_system
CorneaCornea
Corneal neovascularization - excessive ingrowth of blood vessels from the limbal vascular plexus into the cornea, caused by ... Corneal pachymetry Corneal reflex Corneal tattooing Corneal topography Eye disease Keratometry List of keratins expressed in ... For corneal epithelial diseases such as Stevens Johnson Syndrome, persistent corneal ulcer etc., the autologous contralateral ( ... There is a global shortage of corneal donations, severely limiting the availability of corneal transplants across most of the ...
https://en.wikipedia.org/wiki/Cornea
Muse cellMuse cell
... and reduced the severity of corneal inflammation and neovascularization. cell-SCC retained the capacity to suppress corneal ... in mouse and tree shrew wounded corneas prevented the formation of corneal scarring, increased corneal re-epithelialization and ... Corneal scarring Human Muse cells, collected from lipoaspirate, were activated by forming spheroid in the dynamic rotary cell ... These activated Muse spheroids enabled ready differentiation into corneal stromal cells (CSCs) expressing characteristic marker ...
https://en.wikipedia.org/wiki/Muse_cell
Contact lensContact lens
... corneal ulcers and corneal neovascularization-this latter condition, once it sets in, cannot be reversed and will eventually ... corneal edema, descemetocele, corneal ectasia, Mooren's ulcer, anterior corneal dystrophy, and neurotrophic ... The most prominent risks associated with long-term, chronic low oxygen to the cornea include corneal neovascularization, ... "The Corneal Lens", The Optician, 2 September 1949, pp. 141-144. "Corneal Contact Lenses", The Optician, 9 September 1949, p. ...
https://en.wikipedia.org/wiki/Contact_lens
Ocular ischemic syndromeOcular ischemic syndrome
The corneal layers show edema and striae. There is mild anterior uveitis. A cherry-red spot may be seen in the macula, along ... The condition leads to neovascularization in various eye tissues due to the ischemia. The eye pressure may become high due to ... general ocular ischemia may result in retinal neovascularization, rubeosis iridis, cells and flare, iris necrosis, and cataract ...
https://en.wikipedia.org/wiki/Ocular_ischemic_syndrome
Fuchs heterochromic iridocyclitisFuchs heterochromic iridocyclitis
Neovascularisation (growth of new abnormal vessels) is possible and any eye surgery, such as cataract surgery, can cause ... and keratitic precipitates on the posterior corneal surface. Patients are often asymptomatic and the disease is often ...
https://en.wikipedia.org/wiki/Fuchs_heterochromic_iridocyclitis
Dry eye syndromeDry eye syndrome
... corneal ulceration (sterile and infected), corneal neovascularization, corneal scarring, corneal thinning, and even corneal ... Some severe cases result in thickening of the corneal surface, corneal erosion, punctate keratopathy, epithelial defects, ... in which the corneal nerves which stimulate tear secretion are cut during the creation of a corneal flap. Dry eye caused by ... Tear osmolarity may be a more sensitive method of diagnosing and grading the severity of dry eye compared to corneal and ...
https://en.wikipedia.org/wiki/Dry_eye_syndrome
Mir-184Mir-184
High expression is observed in suprabasal cells of the corneal epithelium in the mouse model, along with expression in mouse ... miR-184 has been implicated in ischemia-induced retinal neovascularization. Dysregulation of miRNA expression is thought to ... In mammals, mature miR-184 is particularly enriched in the brain and testis, along with the corneal epithelium. Depolarization ... Finally, a recent study identified miR-184 as essential for embryonic corneal commitment of pluripotent stem cells. • A single ...
https://en.wikipedia.org/wiki/Mir-184
Neurotrophic keratitisNeurotrophic keratitis
... spontaneous corneal epithelium breakdown, poor corneal healing and development of corneal ulceration, melting and perforation. ... Long-lasting neurotrophic keratitis may also cause hyperplasia of the epithelium, stromal scarring and neovascularization of ... Corneal contact lenses can also be used in this stage of the disease, for their protective action to improve corneal healing. ... Corneal sensitivity test: performed by placing a cotton wad or cotton thread in contact with the corneal surface: this only ...
https://en.wikipedia.org/wiki/Neurotrophic_keratitis
List of OMIM disorder codesList of OMIM disorder codes
VSX1 Corneal dystrophy, lattice type I; 122200; TGFBI Corneal dystrophy, lattice type IIIA; 608471; TGFBI Corneal dystrophy, ... with choroidal neovascularization; 608161; PRPH2 Fragile X syndrome; 300624; FMR1 Fragile X tremor/ataxia syndrome; 300623; ... ZEB1 Corneal dystrophy, gelatinous drop-like; 204870; TACSTD2 Corneal dystrophy, Groenouw type I; 121900; TGFBI Corneal ... TGFBI Corneal dystrophy, Thiel-Behnke type; 602082; TGFBI Corneal endothelial dystrophy 2; 217700; SLC4A11 Corneal endothelial ...
https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
Proteases in angiogenesisProteases in angiogenesis
... indicating impaired neovascularization. Neovascularization also is impaired in mice treated with bone marrow derived cells ... Kato, T; Kure, T; Chang, JH; Gabison, EE; Itoh, T; Itohara, S; Azar, DT (2001). "Diminished corneal angiogenesis in gelatinase ... Both enzymes inhibit bFGF induced vascularization in the corneal pocket assay and inhibit VEGF induced angiogenesis in the ... VEGF121 and the truncated VEGF165, in contrast, cause irregular patterns of neovascularization, most likely due to their ...
https://en.wikipedia.org/wiki/Proteases_in_angiogenesis
PerlecanPerlecan
A similar result was produced in the corneal micropocket assay, where FGF-2 is implanted into the cornea of mice and in normal ... While Perlecan suppression causes substantial inhibition of tumor growth and neovascularization in null mice, in contrast, when ... Corneal opacification occurred in both transgenic lines early in development due to greatly increased expression of perlecan, ... Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC (June 2006). "Basement membrane dissolution and reassembly by limbal corneal ...
https://en.wikipedia.org/wiki/Perlecan
HyphemaHyphema
Surgery can be effective for cleaning out the anterior chamber and preventing corneal blood staining. If pain management is ... Spontaneous hyphemas are usually caused by the abnormal growth of blood vessels (neovascularization), tumors of the eye ( ... corneal blood staining, and atrophy of the optic nerve. Small hyphemas can usually be treated on an outpatient basis. There is ... corneal staining, optic atrophy, or vision loss. Rebleeding occurs in 4-35% of hyphema cases and is a risk factor for glaucoma ...
https://en.wikipedia.org/wiki/Hyphema
ThiomerThiomer
Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. Polym. 179: 42-49. doi:10.1016/j. ... of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization". ... Novel therapeutic approach for preventing corneal haze after chemical injuries". Carbohydr. Polym. 179: 42-49. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Thiomer
Scleral reinforcement surgeryScleral reinforcement surgery
Neovascularization may occur, causing blood vessels to protrude through the cracks and leak in the space underneath the ... First, the conjunctiva and Tenon's capsule are incised about 6 mm from the corneal limbus. The lateral, superior, and inferior ...
https://en.wikipedia.org/wiki/Scleral_reinforcement_surgery
PEDFPEDF
... suppresses retinal neovascularization and endothelial cell proliferation. The antiangiogenic residues 24-57 were shown to ... "Pigment Epithelium-derived Factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease ... PEDF, a protein with many functions, has been suggested to play a clinical role in dry eye, choroidal neovascularization, ... Molecules that shift the balance towards PEDF and away from VEGF may prove useful tools in both choroidal neovascularization ...
https://en.wikipedia.org/wiki/PEDF
Fundus photographyFundus photography
Early fundus photos were limited by insufficient light, long exposures, eye movement, and prominent corneal reflexes that ... This is a method of better observing intraretinal microvascular abnormalities, neovascularization at the disc and elsewhere in ...
https://en.wikipedia.org/wiki/Fundus_photography
Gholam A. PeymanGholam A. Peyman
... he applied for a patent that described a method of modifying corneal refractive errors using laser ablation under a corneal ... Oscillatory photodynamic therapy for choroidal neovascularization and central serous retinopathy; a pilot study (2013). ... "INTRASTROMAL CORNEAL MODIFICATION"; 6,221,067, granted April 2001, entitled "CORNEAL MODIFICATION VIA IMPLANTATION"; and others ... In October 2009 Peyman invented and applied for a patent on a method of preventing corneal implant rejection, which was ...
https://en.wikipedia.org/wiki/Gholam_A._Peyman
Neovascularization, Corneal, CL-related Differential DiagnosesNeovascularization, Corneal, CL-related Differential Diagnoses
Ocular insult, including infectious keratitis, immunological conditions, corneal trauma, alkali injury, and contact lens wear ( ... CL), can encourage new blood vessels to grow from the limbus and, hence, neovascularization (NV). ... encoded search term (Neovascularization%2C Corneal%2C CL-related) and Neovascularization, Corneal, CL-related What to Read Next ... Neovascularization, Corneal, CL-related Differential Diagnoses. Updated: Apr 18, 2018 * Author: Barry A Weissman, OD, PhD, FAAO ...
https://emedicine.medscape.com/article/1195886-differential
Corneal Neovascularization - Pipeline Review, H1 2014 is now available at Fast Market Research |...'Corneal Neovascularization - Pipeline Review, H1 2014' is now available at Fast Market Research |...
Corneal Neovascularization - Pipeline Review, H1 2014, provides an overview of the Corneal Neovascularizations therapeutic ... "Corneal Neovascularization - Pipeline Review, H1 2014" is now available at Fast Market Research. From: Fast Market Research, ... Choroidal Neovascularization - Pipeline Review, H1 2014 - Corneal Graft Rejection - Pipeline Review, H1 2014 - Type 1 Diabetes ... The report provides a snapshot of the global therapeutic landscape of Corneal Neovascularization * The report reviews key ...
https://www.ukprwire.com/Detailed/Health_Wellbeing/_Corneal_Neovascularization_-_Pipeline_Review_H1_2014_is_now_available_at_Fast_Market_Research_345946.shtml
Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk...Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk...
Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk ... Corneal neovascularisation following deep anterior lamellar keratoplasty for corneal ectasia: incidence, timing and risk ... timing and risk factors of corneal neovascularisation (NV) after deep anterior lamellar keratoplasty (DALK) for corneal ectasia ... The presence and severity of corneal NV was ascertained based on slit lamp photographs. Potential risk factors for corneal NV ...
https://bjo.bmj.com/content/106/10/1363
Neovascularization, Corneal, CL-related: Background, Pathophysiology, EpidemiologyNeovascularization, Corneal, CL-related: Background, Pathophysiology, Epidemiology
Ocular insult, including infectious keratitis, immunological conditions, corneal trauma, alkali injury, and contact lens wear ( ... CL), can encourage new blood vessels to grow from the limbus and, hence, neovascularization (NV). ... encoded search term (Neovascularization%2C Corneal%2C CL-related) and Neovascularization, Corneal, CL-related What to Read Next ... Neovascularization, Corneal, CL-related. Updated: Apr 18, 2018 * Author: Barry A Weissman, OD, PhD, FAAO; Chief Editor: Hampton ...
https://emedicine.staging.medscape.com/article/1195886-overview
Corneal NeovascularizationCorneal Neovascularization
METHODS: A patient presenting with severe corneal neovascularization in both eyes and Hand Motion (HM) vision was given ... Corneal Neovascularization, Triamcinolone Acetonide and Steroids Michael A. Singer, MD (San Antonio, TX), Rafael Lin Wong, (San ... To determine whether combination therapy of Avastin and Kenalog is useful in the treatment of corneal neovascularization. ...
http://www.evrs.eu/category/vitreoretinal-library/others-than-vr-field/cornea/corneal-diseases/corneal-neovascularization/
Corneal neovascularization | Contact Lens UpdateCorneal neovascularization | Contact Lens Update
Corneal neovascularization. Vessel penetration at the limbus into the cornea beyond the translucent zone. The vessels may empty ... Localized neovascularization may appear subsequent to trauma or inflammatory events. When fitting a patient with silicone ... hydrogel lenses on an EW schedule, baseline neovascularization should not exceed 0.5mm. ...
https://contactlensupdate.com/2012/03/08/corneal-neovascularization/
Final Report Summary - STRONG (European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular...Final Report Summary - STRONG (European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular...
Its efficacy when applied topically in corneal neovascularization has already been demonstrated. Phase I-III trials in the ... It only reduces the oxygen demand of the retina, and thus leads to a regression of the neovascularizations. It is clear that, ... Anti-proliferative laser or cryo treatment of the retina must be performed in iCRVO as soon as neovascularizations are ... The resultant growth of new vessels in the anterior chamber angle (neovascularization of the angle [NVA]) and iris surface ( ...
https://cordis.europa.eu/project/id/305321/reporting
Allergic Conjunctivitis Workup: Approach Considerations, Histologic FindingsAllergic Conjunctivitis Workup: Approach Considerations, Histologic Findings
Corneal neovascularization. Not present, unless secondary to infectious keratitis. Deep corneal neovascularization tends to ...
https://www.medscape.com/answers/1191467-61354/what-is-the-role-of-advanced-point-of-service-testing-in-the-diagnosis-of-allergic-conjunctivitis
Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1<...
Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. In: ... Dive into the research topics of Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus ... Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. / Zhou ... Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. ...
https://tohoku.pure.elsevier.com/en/publications/inhibition-of-mouse-alkali-burn-induced-corneal-neovascularizatio
Category:Blood vessels - Wikimedia CommonsCategory:Blood vessels - Wikimedia Commons
nowiki,vaso sanguíneo; Æð; خوٗن رَگہٕ; pembuluh darah; ਲਹੂ ਨਾੜ; 血管; Hoeh-kńg; د وینې رګ; Кръвоносен съд; Monsisá; kan damarı; رگ; asinsvadi; Xidid; blodkärl; krvni sud; кровоносні судини; ناڑ; 血管; Vaskulo; Xwînborî; 혈관; Қан тамырлары; sanga vaskulo; крвни садови; Krvni sud; bloedvat; রক্তবাহ; vaisseau sanguin; Pembuluh Darah; ڤمبولوه داره; ލޭހޮޅި; Imibhobho yokuhamba kwegazi; naczynie krwionośne; אדער; pembuluh darah; vas sangvin; mạch máu; قان تامىرلارى; Qan tamırları; Bloedvat; крвни суд; Миаш; Sirka; Tsinga; bluid vessel; Қан тамырлары; blodåre; blodåre; Qan damarları; Enët e gjakut; Suun; ಧಮನಿ; vorrâsuonâ; blood vessel; وعاء دموي; крвни суд; हिनू; vas sanguini; 血管; Кан тамырлар; የደም ቧንቧ; véredény; odol-hodi; кровеносные сосуды; ...
https://commons.wikimedia.org/wiki/Category:Blood_vessels
Medicine, Cardiology Division - Grants - Northwestern Scholars
Mechanisms of Anterior Segment Development and Corneal Neovascularization. Kume, T.. NATIONAL EYE INSTITUTE ...
https://www.scholars.northwestern.edu/en/organisations/medicine-cardiology-division/projects/?ordering=type&descending=true&page=2
MIR335 microRNA 335 [Homo sapiens (human)] - Gene - NCBIMIR335 microRNA 335 [Homo sapiens (human)] - Gene - NCBI
MiR-335 promotes corneal neovascularization by Targeting EGFR. Title: MiR-335 promotes corneal neovascularization by Targeting ...
https://www.ncbi.nlm.nih.gov/gene/442904
Eye Health Conditions | Case Definitions and Data Indicators | Project Description | Vision and Eye Health Surveillance System ...Eye Health Conditions | Case Definitions and Data Indicators | Project Description | Vision and Eye Health Surveillance System ...
... corneal neovascularization, or other or unspecified forms of keratitis.. Conjunctivitis. Conjunctivitis includes diagnosis ... Other Corneal disorders. Other Corneal disorders includes diagnosis codes indicating corneal scars, opacities and other ... Choroidal neovascularization AMD. Choroidal neovascularization AMD indicates the presence of ICD10 codes approved after October ... Because this is a new code, Choroidal neovascularization AMD is included in VEHSS as a subgroup of Wet-form AMD.. ...
https://www.cdc.gov/visionhealth/vehss/project/case-definitions-data/diagnosis.html
Severe Ocular Cowpox in a Human, Finland - Volume 21, Number 12-December 2015 - Emerging Infectious Diseases journal - CDC
At 1 year after symptom onset, corneal limbal stem cell deficiency with deep corneal neovascularization was evident. Autologous ... resulting in stable corneal surface 2 months later (Technical Appendix Figure, panel G). Neovascularization regressed, the ... Graef S, Kurth A, Auw-Haedrich C, Plange N, Kern WV, Nitsche A, Clinicopathological findings in persistent corneal cowpox ... and corneal melting progressed (Technical Appendix Figure, panel E). Corneal collagen cross-linking and a fourth AMT were ...
https://wwwnc.cdc.gov/eid/article/21/12/15-0621_article
US Patent Application for Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or...US Patent Application for Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or...
Example 27 Galectin-3 Specific Inhibitor Reduced Corneal Neovascularization Neovascularization in corneas which may occur from ... Thus TD139 was observed to be an effective in vivo inhibitor of corneal neovascularization, which is an important system of ... Example 29 TD139 Inhibited Corneal Fibrosis SMA (smooth muscle actin) is a marker of corneal fibrosis. Eyes were treated with ... or corneal neovascularization (trachoma).. The galectin protein in various embodiments of the method is selected from the group ...
https://patents.justia.com/patent/20150320782
Dry Eye Disease (Keratoconjunctivitis Sicca) Medication: Ophthalmic Lubricants, LFA-1 Antagonists, Mucolytic Agents,...Dry Eye Disease (Keratoconjunctivitis Sicca) Medication: Ophthalmic Lubricants, LFA-1 Antagonists, Mucolytic Agents,...
It decreases inflammation and corneal neovascularization, suppresses migration of PMNs, and reverses capillary permeability. It ... Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci. 1983 Oct. 24 (10):1442 ... Serum eye drops are used for severe dry eye disease with punctate epithelial defects and corneal damage to promote ... Intercellular adhesion molecule-1 (ICAM-1) may be overexpressed in corneal and conjunctival tissues in dry eye disease. The ...
https://emedicine.medscape.com/article/1210417-medication?pa=%2FbFXyV0Kjz5DoSUmI5hn5Fw56YwGiWzzwgBRA%2B60L6ywNrk3h3gpkNl0bLQl%2BHkm%2FjVL0UB%2FZdeboBXk49CFurOwhd8Mdk7tVO%2FdkscsGC4%3D
Other Eye Disorders - Infectious and Inflammatory Diseases | Vision and Eye Health Surveillance System (VEHSS) | Vision Health...Other Eye Disorders - Infectious and Inflammatory Diseases | Vision and Eye Health Surveillance System (VEHSS) | Vision Health...
... corneal neovascularization, or other or unspecified forms of keratitis.. Conjunctivitis. Conjunctivitis includes diagnosis ... Keratitis includes diagnosis codes indicating keratitis, including corneal ulcer, other and unspecified superficial keratitis ...
https://www.cdc.gov/visionhealth/vehss/project/case-definitions-data/infectious-inflammatory-eye-diseases.html
World Journal of Gastroenterology - Baishideng Publishing GroupWorld Journal of Gastroenterology - Baishideng Publishing Group
An Update on Novel Ocular Nanosystems with Possible Benefits in the Treatment of Corneal Neovascularization. Int J Nanomedicine ... miR-340-5p mediates the therapeutic effect of mesenchymal stem cells on corneal neovascularization. Graefes Arch Clin Exp ... Mimouni M, Ouano D. Initial outcomes of mitomycin intravascular chemoembolization (MICE) for corneal neovascularization. Int ... Pharmacological Inhibition of Glutaminase 1 Attenuates Alkali-Induced Corneal Neovascularization by Modulating Macrophages. ...
https://www.wjgnet.com/1007-9327/CitedArticlesInF6?id=10.1016%2Fj.exer.2021.108457
RFA-RM-17-030: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and...RFA-RM-17-030: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and...
Similarly, tools to further dissect the biology of galectins in ocular angiogenesis and corneal neovascularization are desired. ... The National Eye Institute encourages development of technologies and tools that help in facile analysis of retinal, corneal ...
https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-17-030.html
Interaction between Bevacizumab and Murine VEGF-A: A Reassessment | IOVS | ARVO JournalsInteraction between Bevacizumab and Murine VEGF-A: A Reassessment | IOVS | ARVO Journals
As early as 1998, Amano et al. 13 showed that VEGF is required for wound- and inflammation-related corneal neovascularization ... Other studies showed that VEGF is also important for corneal neovascularization associated with herpes simplex virus infection ... Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization. Invest ... The area of neovascularization was selected by freehand draw, and a pixel/length ratio of 194 pixel/wound diameter was applied ...
https://iovs.arvojournals.org/article.aspx?articleid=2164513
Optical Coherence Tomography Angiography in Herpetic Leucoma | Research SquareOptical Coherence Tomography Angiography in Herpetic Leucoma | Research Square
Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. Invest Ophthalmol ... Chan SY, Pan CT, Feng Y. Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography. Cornea. ... En face optical coherence tomography angiography for corneal neovascularisation. BrJ Ophthalmol. 2016; 100 (5):616-621. https ... HSV: Herpes Simplex Virus; OCTA: Optical Coherence Tomography Angiography; VD: Vessel Density; CoNV: Corneal Neovascularization ...
https://www.researchsquare.com/article/rs-1025402/v1
Dr. James Reidy, MD - Chicago, IL | OphthalmologyDr. James Reidy, MD - Chicago, IL | Ophthalmology
Lipid hydrooeroxide induced corneal neovascularization Ueda T, Jenis E, Chou R, Spengler R, Reidy J, and Armstrong D, Invest ... Short-term regression of corneal neovascularization with combination therapy of argon green laser photocoagulation and ... Human corneal stem cells display functional neuronal properties Seigel GM, Sun W, Salvi R, Campbell LM, Sullivan S, Reidy JJ, ... Human corneal stem cells display functional neuronal properties Reidy JJ, Seigel GM, Sun W, Salvi R, Campbell LM, Sullivan S, ...
https://www.doximity.com/pub/james-reidy-md
Gammaplex (Human Immunoglobulin G) - Current Clinical TrialsGammaplex (Human Immunoglobulin G) - Current Clinical Trials
Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions [Recruiting]. Safety ...
http://www.druglib.com/druginfo/gammaplex/trials/
Pseudomonas aeruginosa Corneal Infection Related to Mascara Applicator Trauma -- GeorgiaPseudomonas aeruginosa Corneal Infection Related to Mascara Applicator Trauma -- Georgia
... a dense inflammatory corneal infiltrate was present. Subsequently, diffuse neovascularization of the cornea developed; vision ... Gram stain of corneal scrapings revealed gram-negative rods. Culture of the corneal scrapings and of a sample of the patients ... Pseudomonas aeruginosa Corneal Infection Related to Mascara Applicator Trauma -- Georgia On January 11, 1989, a 47-year-old ... Pseudomonas-induced corneal ulcer associated with contaminated eye mascaras. Am J Ophthalmol 1977;84:112-9. ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00001546.htm
Fast Five Quiz: Erythema MultiformeFast Five Quiz: Erythema Multiforme
In-turned eyelashes, corneal scarring, corneal and conjunctival neovascularization, epithelial proliferation with squamous ... Sjögren-like sicca syndrome of dry eyes, punctate keratitis, corneal pannus, and mucin deficiency in tears ...
https://reference.medscape.com/viewarticle/892382_6
尋找研究成果 - 臺北醫學大學
Step Up To LKStep Up To LK
Corneal neovascularization and the utility of topical VEGF inhibition: ranibizumab (Lucentis) vs bevacizumab (Avastin). Ocul ... with worse neovascularization due to the intense inflammatory response and potential subsequent hemorrhaging, corneal thinning ... Zimprich notes that neovascularization can form in the absence of inflammation; therefore, if the etiology is not inflammatory ... "This condition, whether idiopathic or secondary to corneal or systemic disease, typically opacifies and can interfere with ...
https://www.reviewofoptometry.com/article/step-up-to-lk
The Emerging Role of PPAR Beta/Delta in Tumor AngiogenesisThe Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis
... and bFGF-induced corneal neovascularization in vivo [8]. Moreover, a similar observation also displayed the inhibition of VEGF- ... K. Amano, M. Okigaki, Y. Adachi et al., "Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice," ... K. L. Kim, S. Seo, J. T. Kim et al., "SCF (stem cell factor) and cKIT modulate pathological ocular neovascularization," ... COX2 also mediates IL1 beta-induced angiogenesis in vitro and in vivo [122, 123]. IL1 beta supports neovascularization through ...
https://www.hindawi.com/journals/ppar/2020/3608315/
Colin Willoughby - Research output - Ulster UniversityColin Willoughby - Research output - Ulster University
Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization. Spiteri, N., ... Angiographic and In Vivo Confocal Microscopic Characterization of Human Corneal Blood and Presumed Lymphatic Neovascularization ... Femtosecond Laser-Assisted Lamellar Keratectomy for Corneal Opacities Secondary to Anterior Corneal Dystrophies. Steger, B., ... Collagen corneal shields. Willoughby, C. E., Batterbury, M. & Kaye, S. B., 2002, In: Survey of Ophthalmology. 47, 2, p. 174-182 ...
https://pure.ulster.ac.uk/en/persons/colin-willoughby/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=title&descending=false
Find Research outputs - Yonsei UniversityFind Research outputs - Yonsei University

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Neovascularization, Corneal, CL-related: Background, Pathophysiology, Epidemiology
Neovascularization, Corneal, CL-related: Background, Pathophysiology, Epidemiology (emedicine.medscape.com)
Final Report Summary - STRONG (European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular...
Final Report Summary - STRONG (European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular... (cordis.europa.eu)
(emedicine.medscape.com)
Diabetic Retinopathy: Practice Essentials, Pathophysiology, Etiology
Diabetic Retinopathy: Practice Essentials, Pathophysiology, Etiology (medscape.com)
Diabetic Retinopathy Differential Diagnoses
Diabetic Retinopathy Differential Diagnoses (medscape.com)
Erythema Multiforme Clinical Presentation: History, Physical Examination, Complications
Erythema Multiforme Clinical Presentation: History, Physical Examination, Complications (medscape.com)
Peripheral Ulcerative Keratitis Follow-up: Further Outpatient Care, Complications, Prognosis
Peripheral Ulcerative Keratitis Follow-up: Further Outpatient Care, Complications, Prognosis (medscape.com)
Pellucid Marginal Degeneration (PMD) Treatment & Management: Medical Care, Surgical Care, Consultations
Pellucid Marginal Degeneration (PMD) Treatment & Management: Medical Care, Surgical Care, Consultations (emedicine.medscape.com)
World Journal of Gastroenterology - Baishideng Publishing Group
World Journal of Gastroenterology - Baishideng Publishing Group (wjgnet.com)
Optical Coherence Tomography Angiography in Herpetic Leucoma | Research Square
Optical Coherence Tomography Angiography in Herpetic Leucoma | Research Square (researchsquare.com)
Dr. James Reidy, MD - Chicago, IL | Ophthalmology
Dr. James Reidy, MD - Chicago, IL | Ophthalmology (doximity.com)
Gammaplex (Human Immunoglobulin G) - Current Clinical Trials
Gammaplex (Human Immunoglobulin G) - Current Clinical Trials (druglib.com)
'Corneal Neovascularization - Pipeline Review, H1 2014' is now available at Fast Market Research |...
'Corneal Neovascularization - Pipeline Review, H1 2014' is now available at Fast Market Research |... (ukprwire.com)
Fast Five Quiz: Erythema Multiforme
Fast Five Quiz: Erythema Multiforme (reference.medscape.com)
Step Up To LK
Step Up To LK (reviewofoptometry.com)
Colin Willoughby - Research output - Ulster University
Colin Willoughby - Research output - Ulster University (pure.ulster.ac.uk)
Find Research outputs - Yonsei University
Find Research outputs - Yonsei University (yonsei.pure.elsevier.com)
Kupuna and Special Needs Cats | Lanai Cat Sanctuary | Saving Cats, Protecting Birds
Kupuna and Special Needs Cats | Lanai Cat Sanctuary | Saving Cats, Protecting Birds (lanaicatsanctuary.org)
Constitutive and Inducible Interleukin 8 Expression by Hypoxia and Acidosis Renders Human Pancreatic Cancer Cells More...
Constitutive and Inducible Interleukin 8 Expression by Hypoxia and Acidosis Renders Human Pancreatic Cancer Cells More... (aacrjournals.org)
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Home (optometry.ophthalmologyconferences.com)
Department of Optics and Photonics - Research output - National Central University
Department of Optics and Photonics - Research output - National Central University (scholars.ncu.edu.tw)
KID syndrome - About the Disease - Genetic and Rare Diseases Information Center
KID syndrome - About the Disease - Genetic and Rare Diseases Information Center (rarediseases.info.nih.gov)
Ocular Rosacea Clinical Presentation: History, Physical, Causes
Ocular Rosacea Clinical Presentation: History, Physical, Causes (medscape.com)
Ocular Rosacea Clinical Presentation: History, Physical, Causes
Ocular Rosacea Clinical Presentation: History, Physical, Causes (medscape.com)
Amniotic Membrane ProKera for Ocular Surface Disorders
Amniotic Membrane ProKera for Ocular Surface Disorders (medscape.com)
Stevens-Johnson Syndrome: Practice Essentials, Background, Pathophysiology
Stevens-Johnson Syndrome: Practice Essentials, Background, Pathophysiology (medscape.com)