Corneal Endothelial Cell Loss: Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.Endothelium, Corneal: Single layer of large flattened cells covering the surface of the cornea.Descemet Stripping Endothelial Keratoplasty: A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.Keratoplasty, Penetrating: Partial or total replacement of all layers of a central portion of the cornea.Corneal Edema: An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Fuchs' Endothelial Dystrophy: Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Phacoemulsification: A procedure for removal of the crystalline lens in cataract surgery in which an anterior capsulectomy is performed by means of a needle inserted through a small incision at the temporal limbus, allowing the lens contents to fall through the dilated pupil into the anterior chamber where they are broken up by the use of ultrasound and aspirated out of the eye through the incision. (Cline, et al., Dictionary of Visual Science, 4th ed & In Focus 1993;1(1):1)Corneal Diseases: Diseases of the cornea.Anterior Chamber: The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)Lens Implantation, Intraocular: Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.Cataract Extraction: The removal of a cataractous CRYSTALLINE LENS from the eye.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Phakic Intraocular Lenses: Lenses, generally made of plastic or silicone, that are implanted into the eye in front of the natural EYE LENS, by the IRIS, to improve VISION, OCULAR. These intraocular lenses are used to supplement the natural lens instead of replacing it.Sodium Tetradecyl Sulfate: An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Collagen Type VIII: A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.Lenses, Intraocular: Artificial implanted lenses.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Microsurgery: The performance of surgical procedures with the aid of a microscope.Lens Nucleus, Crystalline: The core of the crystalline lens, surrounded by the cortex.Capsulorhexis: The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (Dorland, 28th ed)Viscoelastic Substances: Substances that display the physical properties of ELASTICITY and VISCOSITY. The dual-nature of these substances causes them to resist applied forces in a time-dependent manner.Conjunctival DiseasesTissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Corneal Surgery, Laser: Surgical techniques on the CORNEA employing LASERS, especially for reshaping the CORNEA to correct REFRACTIVE ERRORS.Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)Niobium: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)Sound: A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.Ultrasonic Therapy: The use of focused, high-frequency sound waves to produce local hyperthermia in certain diseased or injured parts of the body or to destroy the diseased tissue.Electronics: The study, control, and application of the conduction of ELECTRICITY through gases or vacuum, or through semiconducting or conducting materials. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Electronics, Medical: The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Cardiac Resynchronization Therapy Devices: Types of artificial pacemakers with implantable leads to be placed at multiple intracardial sites. They are used to treat various cardiac conduction disturbances which interfere with the timing of contraction of the ventricles. They may or may not include defibrillating electrodes (IMPLANTABLE DEFIBRILLATORS) as well.Orthopedic Fixation Devices: Devices which are used in the treatment of orthopedic injuries and diseases.Costa RicaPrince Edward Island: An island in the Gulf of St. Lawrence constituting a province of Canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is Charlottetown. Discovered by the French in 1534 and originally named Ile Saint-Jean, it was renamed in 1799 in honor of Prince Edward, fourth son of George III and future father of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p981 & Room, Brewer's Dictionary of Names, 1992, p433)Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)Spinal Fusion: Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)Pseudarthrosis: A pathologic entity characterized by deossification of a weight-bearing long bone, followed by bending and pathologic fracture, with inability to form normal BONY CALLUS leading to existence of the "false joint" that gives the condition its name. (Dorland, 27th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Safety of DSAEK in patients with previous glaucoma filtering surgery. (1/26)

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Risk factors for endothelial cell loss after phacoemulsification: comparison in different anterior chamber depth groups. (2/26)

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Effect of incision width on graft survival and endothelial cell loss after Descemet stripping automated endothelial keratoplasty. (3/26)

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Donor risk factors for graft failure in a 20-year study of penetrating keratoplasty. (4/26)

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Clinicopathologic findings in failed descemet stripping automated endothelial keratoplasty. (5/26)

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Anterior segment parameters using Pentacam and prediction of corneal endothelial cell loss after cataract surgery. (6/26)

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Corneal endothelial toxicity of air and SF6. (7/26)

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Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. (8/26)

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*Reata Pharmaceuticals

"RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD". April 15 ... corneal endothelial cell loss associated with cataract surgery Friedreich's ataxia, and mitochondrial myopathies. Reata is also ... the normal three-dimensional structure of target proteins or generally enhancing the folding environment of the cell. Defects ...

*Bullous keratopathy

The corneal endothelial cells normally do not undergo mitotic cell division, and cell loss results in permanent loss of ... membrane endothelial keratoplasty versus Descemet's stripping automated endothelial keratoplasty for corneal endothelial ... When endothelial cell counts drop too low, the pump starts failing to function and fluid moves anterior into the stroma and ... In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. ...

*Krukenberg's spindle

Non-transparent collagen deposits appearing following loss of corneal endothelial cells Pigment dispersion syndrome Krukenberg ... January 2000). "Corneal guttata associated with the corneal dystrophy resulting from a betaig-h3 R124H mutation". 84 (1): 67-71 ... Krukenberg's spindle is the name given to the pattern formed on the inner surface of the cornea by pigmented iris cells which ... Painful red eye with photophobia associated with inflammation Corneal deposits also known as cornea verticillata, caused by ...

*Omaveloxolone

... and prevention of corneal endothelial cell loss following cataract surgery. The effects of omaveloxolone and related synthetic ...

*Glycosaminoglycan

... and affect the motility of corneal endothelial cells.[17] In summary, KS plays an anti-adhesive role, which suggests very ... loss of hydration within the corneal stroma is believed to be the cause of corneal haze, thus supporting the long-held ... including cell adhesion, regulation of cell growth and proliferation, developmental processes, cell surface binding of ... Fibroblasts, mesothelial cells, and certain types of stem cells surround themselves in a pericellular "coat", part of which is ...

*Burkhard Dick

with I Conrad-Hengerer, M Al Juburi, T Schultz, FH Hengerer FH: Corneal endothelial cell loss and corneal thickness in ... in pediatric cataracts and in individuals who had undergone corneal refractive surgery or are suffering from corneal disease. ...

*Fibrin scaffold

Bullous keratopathy that is characterized by corneal stromal edema related to cell loss and endothelial decompensation as well ... results vision problems due to loss of corneal transparency. Fibrin glue is used as a sutureless method onto the corneal ... biodegradable cell-adhesive scaffolds since cells can not attach to synthetic polymers and take proper signals for normal cell ... toxicity and cell adhesion are concerned. When there is a trauma in body, cells at site start the cascade of blood clotting and ...

*Intraocular lens

They are notorious for their negative impact on the corneal endothelial lining, which is vital for maintaining a healthy clear ... The main complication with this type is their tendency to cause endothelial cell reduction. Sulcus-supported PIOLs: this type ... Some of the risks that FDA have been found so far during a three-year study of the Artisan are: a yearly loss of 1.8% of the ... endothelial cells, 0.6% risk of retinal detachment, 0.6% risk of cataract (other studies have shown a risk of 0.5 - 1.0%), and ...

*Alpha-enolase

"Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease". ... Reduced expression of the enzyme has been found in the corneal epithelium of people suffering from keratoconus. CagA protein ... leads to hemolytic anemia in affected homozygous carriers of loss of function mutations in ENO1. As with other glycolysis ... and activated immune cells, leading to systemic infection or tissue invasion; an oxidative stress protein in endothelial cells ...

*Phakic intraocular lens

Endothelial cell loss especially for the anterior chamber PIOLs. A study observed a continual steady loss of endothelial cells ... Corneal endothelial cell count less than 2000-2500 cells/mm² is a relative contraindication for PIOL implantation. PIOLs have ... Beyond these limits there is an increased risk of developing corneal ectasia (i.e. corneal forward bulging) due to thin ... Central corneal power in diopters R : Patient Refraction at the corneal vertex d : Effective lens position in mm The effective ...

*Calotropis gigantea

... the remaining corneal endothelial cells usually recover with complete resolution of the corneal edema and a return to normal ... The milky latex sap of Calotropis gigantea is a known cause of toxic keratoconjunctivitis and reversible vision loss. ... Although there is some permanent damage to the corneal endothelium with decreased endothelial cell count and irregular shape, ... The clinical course of this condition suggests that Calotropis is paradoxically relatively nontoxic to corneal epithelium and ...

*Corneal transplantation

... the loss of endothelial cells that maintain transparency is much higher in DSEK compared to a full-thickness corneal transplant ... Endothelial cells and the Descemets membrane are left in place. This technique is used in cases of anterior corneal ... Gradual reduction in endothelial cell density over time can lead to loss of clarity and require repeating the procedure. ... These procedures correct corneal endothelial failure, but are not able to correct corneal scarring, thinning, or surface ...

*Allon Barsam

"Endothelial Cell Loss After Needle-Push Insertion Descemet Stripping Endothelial Keratoplasty (DSEK)". Cornea. 35 (6): e16-17. ... establishing himself as an expert on the corneal disease. He also pioneered a new technique for corneal transplant surgery ... Barsam, A.; Petrushkin, H.; Brennan, N.; Bunce, C.; Xing, W.; Foot, B.; Tuft, S. (2015-04-01). "Acute corneal hydrops in ... Allon Barsam, MA MB BS FRCOphth, is a London-based ophthalmologist in cataract surgery, refractive surgery and corneal and ...

*Pre-Descemet's Endothelial Keratoplasty

Pneumatic dissection induced endothelial cell loss is also noted to be not higher than or in fact better than other endothelial ... Conventionally in a corneal transplantation, doctors use a whole cornea or parts of the five layers of the cornea to perform ... Normal endothelial cell count at birth is about 4000 cells/sq mm. Adult population has a count of about 2500 to 2800 cells/Sq ... There are additional research studies in progress to elucidate the regenerating capacity of the endothelial cells in vivo. ...

*CYR61

... has potent angiogenic activity upon endothelial cells and induces neovascularization, first demonstrated in a corneal ... However, excessive matrix deposition can lead to fibrosis, scarring, and loss of tissue function. In skin wounds, CYR61 ... CYR61 is able to support cell adhesion, stimulate cell migration, promote growth factor-induced cell proliferation and ... prostate cancer cells, ovarian carcinoma cells, and squamous carcinoma cells. Clinically, CYR61 expression correlates with the ...

*Eye development

Surface ectoderm produces the following parts: lens corneal epithelium skin of eyelid Neural crest cells are themselves derived ... Overexpression of Shh causes a loss of eye structures. Retinoic acid generated from vitamin A in the retina plays an essential ... extraocular muscles endothelial lining of blood vessels of the eye blood vessels in sclera & choroid Sclera & Choroid Vitreous ... ganglion cells, bipolar cells, horizontal cells, amacrine cells and Muller glia. This indicates that morphogenesis of the optic ...

*Perlecan

It does seem counterintuitive that endothelial cells would proliferate less quickly due to loss of perlecan and its ... Ohji M, SundarRaj N, Hassell JR, Thoft RA (February 1994). "Basement membrane synthesis by human corneal epithelial cells in ... This difference between endothelial cells from the study in 2007 and the epithelial cell studied in these experiments is ... components and cell-surface molecules. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and ...

*Urbach-Wiethe disease

It is also thought to play a role in endochondral bone formation, tumor biology, endothelial cell proliferation and blood ... The disease is caused by loss-of-function mutations to chromosome 1 at 1q21, the extracellular matrix protein 1 (ECM1) gene. ... corneal ulceration, and focal degeneration of the macula. Although the dermatological changes are the most obvious symptoms of ... The discovery that the loss of ECM1 expression leads to the symptoms associated with Urbach-Wiethe disease suggests that ECM1 ...

*Cord factor

... cells, while also leading to mature Th1 cells, and thus leading to immunity. Then, with IL-12 available, Th1 cells and NK cells ... Furthermore, cord factor's production of TNF-α, also known as cachectin, is also able to induce cachexia, or loss of weight, ... Activated macrophages and neutrophils also cause an increase in vascular endothelial growth factor (VEGF), which is important ... of Mycobacterium tuberculosis Induces Corneal Angiogenesis in Rats". Infection and Immunity. 68 (10): 5991-5997. doi:10.1128/ ...

*ALOX15

... mammary epithelial cells, the Reed-Sternberg cells of Hodgkin's lymphoma, corneal epithelial cells, and dendritic cells; it is ... vascular endothelial cells, joint Synovial membrane cells, seminal fluid, prostate epithelium cells, and mammary ductal ... Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain- ... 15-Oxo-ETE which inhibits the growth of cultured Human umbilical vein endothelial cells and various human cancer cell lines; it ...

*Proteases in angiogenesis

Activated c-kit is then able to recruit hematopoietic, endothelial and mast cell progenitor cells, these cells are then ... for this control excessive proteolysis could lead to damage of the tissue and the loss of anchorage points for migrating cells ... Kato, T; Kure, T; Chang, JH; Gabison, EE; Itoh, T; Itohara, S; Azar, DT (2001). "Diminished corneal angiogenesis in gelatinase ... Co-cultures consisting of pericytes and endothelial cells induce the expression of TIMP-3 by pericytes, while endothelial cells ...

*Endothelium

For the endothelium of the cornea, see corneal endothelium.. Endothelium. Diagram showing the location of endothelial cells ... Main article: Endothelial dysfunction. Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for ... squamous cells called endothelial cells. Endothelial cells in direct contact with blood are called vascular endothelial cells, ... Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. These cells have ...

*Thrombospondin-2

Armstrong DJ, Hiscott P, Batterbury M, Kaye S (Jun 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 ... "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism". Molecular Biology ... Kishi M, Nakamura M, Nishimine M, Ishida E, Shimada K, Kirita T, Konishi N (Jun 2003). "Loss of heterozygosity on chromosome 6q ... It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the ...

*Chromosome 5 (human)

Endothelial cell-specific molecule 1 DTDST: diastrophic dysplasia sulfate transporter EIF4E1B: encoding protein Eukaryotic ... Researchers have not identified all of these genes or determined how their loss leads to the features of the disorder. They ... Diastrophic dysplasia Ehlers-Danlos syndrome Familial adenomatous polyposis Granular corneal dystrophy type I Granular corneal ... Changes to chromosome 5 include an extra segment of the short (p) or long (q) arm of the chromosome in each cell (partial ...

*Confocal microscopy

... and quantification of endothelial cells of the cornea.[9] It is used for localizing and identifying the presence of filamentary ... guarantees better mechanical stability and avoids the losses due to the window. ... fungal elements in the corneal stroma in cases of keratomycosis, enabling rapid diagnosis and thereby early institution of ... "The Journal of Cell Biology. 105 (1): 41-48. doi:10.1083/jcb.105.1.41. ISSN 0021-9525. PMC 2114888 . PMID 3112165.. ...
TY - JOUR. T1 - Endothelial cell changes are associated with pulmonary edema and respiratory distress in mice infected with the WA1 human Babesia parasite. AU - Hemmer, Ruth M.. AU - Wozniak, Edward J.. AU - Lowenstine, Linda J. AU - Plopper, Charles. AU - Wong, Viviana. AU - Conrad, Patricia A. PY - 1999/6. Y1 - 1999/6. N2 - A C3H/HeN mouse model was established to study the pathogenesis of the human babesial parasites, WA1 and Babesia microti. To evaluate the course of parasitemia and the associated lesions, mice were inoculated intraperitoneally with either WA1-infected, B. microti-infected, or uninfected hamster red blood cells. WA1-infected mice developed dyspnea and moderate parasitemias, after which death occurred. Babesia microti-infected mice experienced low parasitemias with no apparent morbidity or mortality. WA1-infected mice were thrombocytopenic but not anemic. Hemograms for B. microti-infected mice were similar to controls. Postmortem examination of WA1-infected mice revealed ...
Purpose: To evaluate corneal endothelial cell loss after phaco with ExPress implant compared to phaco trabeculectomy. Methods: Forty eyes of forty patients affected by cataract and open angle glaucoma were randomized to Micro incision cataract surgery (MICS) phaco with Express P50 implant under scleral flap (group 1) or MICS safe-phacotrabeculectomy (group 2) after informed consent. All patients were operated by two-site surgery. There were no statistically significant differences in age, sex, anterior chamber depth and axial length. Non contact corneal specular microscopy (Tomey 3000 tm) was performed in all eyes before and 1st, 3rd , 6th months after surgery. Endothelial cell density (CCD), coefficient of variation in cell size (CV) and percentage of hexagram cells (HEX) between the two groups were considered before and after surgery. Mean endothelial cell count was measured in the central corneal area and in the superior area close to Express implant and close to trabeculectomy site. One-way ...
Cornea. 2010 May;29(5):523-7. doi: 10.1097/ICO.0b013e3181c11e5d. Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
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Most browsers are set to automatically accept cookies. You can change your preferences at any time and set your browser to reject or remove them.. Google Chrome, Mozilla Firefox, Microsoft Internet Explorer, Apple Safari, Safari su iPhone, iPad, o iPod touch, Android Chrome.. We inform you that, if you choose to block all cookies, you may not be able to access or use important functionalities provided by the websites. Furthermore, if you cancel all cookies, you might lose the preferences you have set previously on the websites you visit.. For further information on behavioural advertising, third party cookies, and to selectively set your opt-outs for the major companies that apply it, you can go to the website:. http://www.youronlinechoices.com/it/. ...
Cataract surgical techniques have significantly changed in recent years with the widespread adoption of smaller and smaller clear corneal incisions for phacoemulsification. Microincision surgery has many advantages, including reduced surgically induced astigmatism, faster visual recovery, and reduced intra and postoperative inflammation. In the recent times, microcoaxial phacoemulsification has gained popularity. The main advantage of this newer technique is that it uses the same methods as the conventional method but with smaller incisions. Curently, microcoaxial phacoemulsification is being performed through 1.8 as well as 2.2 mm incisions. However, there is still a debate as to which is the best absolute incision size for microcoaxial cataract surgery.. The aim of this study is to evaluate incision stability following microcoaxial phacoemulsification performed through 1.8 and 2.2 mm systems, as well as compare intraoperative performance and postoperative outcomes following microcoaxial ...
Laser eye surgery to correct vision problems does not appear to be associated with lasting changes to cells lining the inside of the cornea at nine years after the procedure, according to a report in the November issue of Archives of Ophthalmology, one of the JAMA/Archives journals.. Two types of laser surgery""photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK)""are often used to correct refractive errors such as nearsightedness, according to background information in the article. Little is known about how these procedures affect the cornea, the transparent membrane covering the eye, on the cellular level over the long term.. Sanjay V. Patel, M.D., and William M. Bourne, M.D., of Mayo Clinic, Rochester, Minn., studied 29 eyes of 16 patients who had undergone LASIK or PRK. Photographs of the cells lining the cornea (endothelial cells) were taken and analyzed before and nine years after surgery. The annual rate of corneal endothelial cell loss in the eyes of patients who ...
In a clinical prospective, randomised study, 28 cataract eyes with a median age of 74.96 years were enrolled and devided into 4 groups: group 1 = 0.9 mm incision, group 2 = 1.8 mm incision, group 3 = 2.2 mm incision using the newly developed microincision forceps. The data was compared to the control group 4 eyes with a 2.2 mm incision using standard utrata forceps. Incision size was measured using a caliper intraoperativly and capsulorhexis shape was evaluated by analyzing surgical videos ...
Fuchs endothelial dystrophy is a progressive, bilateral disease of the corneal endothelium, which eventually leads to corneal decompensation. In the early stage, some patients develop visually significant cataract. During cataract surgery ultrasound (US) power is used to emulsify the lens, which leads to endothelial cell loss and tissue damage. The reduction of US power has become the primary surgical goal in cataract surgery, which is especially important in patients with Fuchs endothelial dystrophy to limit endothelial cell loss.. In 2006, Alcon Surgical introduced a torsional mode in its phacoemulsification system (Infiniti Vision System). It includes a handpiece that produces rotary oscillations of the phacoemulsification tip and is suggested to reduce the amount of US power required to remove the cataractous nucleus, because it does not produce repulsion and breaks up the cataract by shearing and not by the conventional jackhammer effect. This reduction in US power, could lead to less ...
Methods 19 human corneoscleral rims were divided into six groups, mounted on an anterior chamber maintainer and cut with a femtosecond laser programmed to the following patterns: zigzag (A), mushroom (B) and top hat (C) in both full (1) and partial (2) thicknesses. The pressure required to produce leakage from the corneal incision was then measured. Eight additional corneas were cut with the zigzag pattern: four full and four partial thickness, prepared and transported per standard eye bank protocol, and analysed for endothelial cell loss with trypan blue staining and digital image analysis.. ...
Despite the fact that the GWAS publication noted that genetic variations in TCF4 polymorphisms contribute to the development of FED, this correlation also needs to be verified by a case control study. Therefore, we performed this meta-analysis to provide the highest level of evidence for the association between TCF4 polymorphisms and the risk of FED. With a total of 5370 participants, this meta-analysis focused on the association between TCF4 variants and the risk of FED, thirteen studies addressing one or more SNPs in TCF4 (rs613872, rs17595731, rs9954153, and rs2286812) were included. The pooled results showed that a significant association was detected between FED risk and the rs17595731, rs613872, rs9954153, and rs2286812 SNPs. This s consistent with the findings presented in the GWAS publication [8]. For rs613872, in order to achieve robust and reliable results for the meta-analysis of the association between rs613872 and FED risk, we performed a series of analyses. These sensitivity ...
A widely known D cartridge is mostly used to inject hydrophobic acrylic IOLs with a wound assisted technique through 2.2-2.4 mm incisions. The wound stretch through these incision sizes has been shown to be limited and is widely accepted. The main innovative features of the new cartridge system are 1) dedicated depth guard behind the cartridge tip, ensuring a fixed and controlled entry of the tip into the corneal incision. 2) a single hand push injection mechanism which allows an uninterrupted IOL delivery ...
... ,Dodick nucleus cracker cross-action longitudinally serrated paddle shaped jaws for cracking the nucleus through a 3.0 mm incision.,medicine,medical supply,medical supplies,medical product
La microscopía especular nos permite realizar el estudio del endotelio corneal. Puesto que la distribución celular es prácticamente uniforme, mediante la...
Purpose : To compare central corneal thickness (CCT), corneal endothelial cell density, and lens capsule thickness in normotensive patients with and without pseudoexfoliation syndrome (PXS) Methods : This was a prospective, comparative, descriptive study. Normotensive candidates for cataract surgery with (study group) and without (control group) PXS were enrolled in the study. CCT ...
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When is it appropriate to refer patients with Fuchs endothelial dystrophy (FED) for cataract surgery? In this article the characteristics of FED are explored along with the surgical approaches that can be taken when cataract develops in these patients.. ...
Functional impairment of the human corneal endothelium can lead to corneal blindness. In order to meet the high demand for transplants with an appropriate human corneal endothelial cell density as a prerequisite for corneal function, several tissue engineering techniques have been developed to generate transplantable endothelial cell sheets. These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. This review gives an overview about currently used materials for the generation of transplantable corneal endothelial cell sheets with a special focus on thermo-responsive polymer coatings.
A robotic-assisted Gastrectomy procedure is performed by making four small incisions - one 12 mm incision at the patients belly button, and three 8mm incisions at the upper abdomen.
The last year or so I found that my sensitivity to light really increased. I was having a lot of trouble in rooms lit with fluorescent and CFL bulbs. The last few visits to eye doctor I was asking for help with this and possibly getting tinted gasses to wear indoors. The treatment for Fuchs is a sodium chloride based ointment in the eyes at night or drops times a day ...
Yet another issue with any P-IOL is endothelium cell loss. A certain amount of endothelial cells need to remain healthy to keep the cornea nourished. We all lose endothelial cells as part of the aging process, but virtually all studies show that all P-IOLs induce endothelial cell loss and accelerate loss in the ensuing years. Our organization argued strongly for the FDA to recognize this issue and the currently FDA approved method is for the doctor to take a count of the endothelial cells in a square millimeter and compare this count to a sliding scale of anticipated loss and expected time the P-IOL will be implanted. If you dont have enough cells to start, the P-IOL is contraindicated. At some point in time the number of cells will be diminished to where safety is a concern and the P-IOL will need to be removed. What fries my eggs is that very few surgeons implanting the P-IOLs are doing the preoperative endothelial cell count and even fewer have requiring the patient return on a regular ...
Laparoscopic surgery provides excellent visualization of the abdominal cavity through a minimally invasive technique. We are able to perform ovariectomies (spay) and obtain biopsies through two 5 mm incisions. The incision made with the laparoscopic assisted gastropexy is smaller than the traditional incision. Laparoscopic surgery is associated with less pain, a more rapid surgical recovery time and a decreased risk of complications from bleeding ...
Video created by University of Michigan for the course Introduction to Cataract Surgery. This unit begins in the operating room after the patient is prepped and draped. It covers each step needed for you to access the lens. Once you begin ...
Disclosed are viscoelastic compositions and methods of their use in treating joints, especially in conjunction with trauma and osteoarthritis.
I use Sealey torque wrenches and they work well enough for me. Remember that if youre buying one to use with bottom brackets itll need to measure torque in both directions (usually having a push-through head), many dont.. I very definately fall into the inexperienced how do you develop feel in the first place camp which is why I use torque wrenches. Torque wrenches are a lot longer than the usual allen key sets and so give a very different feel, but once youve set a bolt to the correct torque theres nothing to stop you then tweaking it back and forth a little with an allen key.. There are dangers though (as Ive found to my cost) the most obvious being blindly tightening something waiting for the torque wrench to click, until the bolt snaps! You still need to be aware of tightness just in case.. ...
Since its introduction in 2002, the OCULUS Pentacam® has proven itself indispensable and has come to represent the Gold Standard worldwide. Heres why: Contact-free Pentacam® measurement provides the basis for precise and reliable diagnostics and successful treatment of the anterior segment.. ...
The problem can be summarize with this steps: - i create with the OOo Api and Java a document Writer with a table; - i enter a text in a cell in the first row; - then i change the properties of the cell/text with this code: XText xCellText=(XText)UnoRuntime.queryInterface( XText.class,xTable.getCellByName(xCellName)); XTextCursor xtc=xCellText.createTextCursor(); XPropertySet xCursorProps=(XPropertySet)UnoRuntime.queryInterface (XPropertySet.class,xtc); xCursorProps.setPropertyValue(CharColor,new Integer(0x000000)); xCursorProps.setPropertyValue(CharFontName,Arial); xCursorProps.setPropertyValue(CharHeight,new Float(8.0)); xCursorProps.setPropertyValue(CharWeight, new Float(com.sun.star.awt.FontWeight.BOLD)); xCursorProps.setPropertyValue(CharRotation,new Short(900)); xcell=xTable.getCellByName(xCellName); xPropsCell=(XPropertySet)UnoRuntime.queryInterface (XPropertySet.class,xcell); xPropsCell.setPropertyValue(VertOrient,new Short(com.sun.star.text.VertOrientation.CENTER)); ...
Diabetic retinopathy is one of the leading causes of vision loss in industrialized countries. Despite recent advances, the biochemical basis for the development of this diabetic complication is uncertain. Although retinal circulation is unique in that it is readily observable noninvasively, retinal tissue is extremely difficult to study in humans because of the problems inherent in obtaining fresh, appropriate biopsy material. Moreover, because of the difficulties in working with animal models of diabetic retinopathy, such as the dog, many investigators have turned to cell-culture models, especially those using primary cultures of retinal capillary endothelial cells and pericytes. Diabetic retinopathy involves both morphological and functional changes in the retinal capillaries. Morphological changes include basement membrane thickening and pericyte disappearance; functional changes include one important early change-increased permeability-which may be attributable to endothelial cell changes ...
Regular cervical screening is the best way to identify abnormal changes in the cells of the cervix at an early stage.. Women who are 25-49 years of age are invited for screening every three years. Women who are 50-64 years of age are invited every five years. For women who are 65 years of age or older, only those who havent been screened since they were 50, or those who have had recent abnormal tests, are offered screening.. Make sure that your GP surgery has your up-to-date contact details, so that you continue getting screening invitations.. Its important that you attend your cervical screening tests, even if youve been vaccinated for HPV, because the vaccine doesnt guarantee protection against cervical cancer.. If youve been treated for abnormal cervical cell changes, youll be invited for screening more frequently for several years after treatment. How regularly you need to go will depend on how severe the cell change is.. Although it can identify most abnormal cell changes in the ...
What about a way to make cells change depending on how old they are? This could be useful to ensure certain cells dont do anything and waste energy until they mature enough to split ...
Specular microscopy is a non-invasive photographic technique that allows you to visualize and analyse the corneal endothelium. This test is used to monitor the number, density, and quality of endothelial cells that line the back of the cornea. A microscope magnifies the cells thousands of times and the image is captured with a camera or video camera. The number of cells within one square millimeter are counted and recorded. The endothelium of a young, ten-year-old, healthy cornea has approximately 3,500 cells in each square millimeter. Normal aging causes the cells to gradually decrease over time. By age 60, most people have approximately 2,500 cells per square millimeter.. ...
The use of phacoemulsification energy in cataract surgery has been linked to corneal edema and endothelial cell loss. Eliminate it altogether and help sur
A doctor gynecologist for 5 days progressed severe LBP with left sciatica came to the hospital with MRI lumbar spine showing huge PLD L4-5 left side. On examination, SLRS was positive in the right leg, shooting to the left and 10 degrees in the left. Severe weakness of dorsiflexion left foot with hypalgesia of the S1 territory left side. She was in agonizing pain and she was operated 3 hours after admission. A 15 mm incision was done after image-intensifier control. Fenestration after drilling the medial aspect of the left L4-5 facet before violating the ligamentum flavum was done and foraminotomy of left L5 root was performed. The root was severely compressed, for what the hard fragments were pulled down to the disc space and removed. Prompt postoperative recovery off her sciatica and immediate normalization of the power ...
Im not sure if I should code as 44145 or 44207 Procedure: Laparoscopic sigmoid resection w/ colorectal anastamosis. ...12-mm incision made in m
Purpose: To evaluate the use of Pentacam densitometry maps in conjunction with a new laboratory protocol as a method to measure differences in UVA-RF crosslinking induced changes in whole globe porcine eyes.. Methods: 18 fresh whole globe porcine eyes were obtained ,24 hours postmortem in saline on ice from Sioux-Preme (Sioux City, IA). Epithelium was removed with a dull blade, and globes were soaked in Blood Bank Buffered Saline (Fisher Scientific, Agawam MA) for ,20 minutes at 37°C. Globes were mounted on a holder and an intraocular pressure of 30mmHg was applied to the globe through a cannula. Drops of 0.1% Riboflavin with 0.25%HPMC were applied to the corneas every 2 minutes for a total of 15 minutes at 37°C. The corneas were aligned to a Pentacam HR (Oculus Optikgeräte GmbH) outfitted with a 475nm (±25nm) notch filter to eliminate fluorescence saturation. Three pre-illumination images were acquired for each cornea. Avedros KXL-II (Avedro, Inc. Waltham MA) was used to illuminate a 4mm ...
The more dots there are, the more accurate a picture you get when you connect them. Cancer researchers adopting that philosophy have developed a new imaging technology that could give scientists the ability to simultaneously ...
An advantage to using a cell reference in the COUNTIF criteria is that the result will automatically update, if the value in the referenced cell changes. In the screenshot below, you can see that the passing score has been increased from 50 to 70. Because the Passed formula uses a reference to cell F5, the count is automatically updated. The Failed formula has the passing score of 50 typed into the criteria, so that value would have to be changed, before the result is updated.. ...
Pre-Descemets endothelial keratoplasty (PDEK) offers surgeons a safe and effective means of treating various endothelial dysfunctions
Under general anesthesia, two 2mm incisions are used on each side to pass a tiny video camera and a single dissecting instrument into the chest. Because of the way we perform this procedure at Stanford, the incisions are so small that this is sometimes called needlescopic surgery. The sympathetic trunk is visualized and divided at the levels appropriate to the patients problem area. Nearly all patients are discharged home the same day and suffer only very minor discomfort for a few days after the operation. Although many patients experience a mild increase in sweating in other parts of their body, this is rarely problematic, and 95-98% of patients will be cured of their excessive sweating when the appropriate levels of the sympathetic trunk are divided. Patient satisfaction has been outstanding.. ...
CHANGE CHANGE CHANGE: Laparoscopic technology has been steadily improving allowing increasingly complex procedures. The "Minimally Invasive" surgical process involves operating inside the abdomen through very small incisions while watching a video monitor. The use of newer High-frequency sound or Tissue fusion devices has replaced the old laser technology for nearly all Laparoscopic surgeries. Usually, three tiny 5 mm incisions are made in the patients abdomen to accomplish a Laparoscopic Hysterectomy. The procedure involves removal of the uterus and tubes. The ovaries are usually left in place but may be removed for ovarian cancer risk, endometriosis or other specific reasons.. BENEFITS: most women experience less pain, shorter hospital stay, and quicker recovery time (just ten to fourteen days). Other interests include less risk of surgical complications, scar tissue and infection. Furthermore, there is better long-term support of the top of the vagina which may protect sexual health and ...
Modular System for Anterior and Posterior Segment. Reliable, compact, safe, versatile, Pulsar2MinimalStress will meet any surgeons desires, any institutions needs. A patented and unique phaco driver minimizes the ultrasonic energy delivered to the eye. The first step for "cool phaco & MICS". Wide range of dedicated accessories for MICS: phaco needles for 1.0 up to 1.5 mm incision size, irrigating chopper, nucleus manipulator, capsulorhexis forceps and bimanual I/A probes. Pneumatic guillotine cutters (disposable and reusable) up to 2000 cuts/min. ACC (Asymmetrical Cutting Cycle) prevents vitreous body traction. Wide range of 23G dedicated accessories for Minimally Invasive Vitrectomy: high speed posterior vitreous cutter, round incision knife, infusion scleral cannula, microforceps, aspiration cannula, pics, endo-illuminating fiber optic probe.. Product URL : http://www.ophtec.com/professional/en/cataract- ...
The medical exam table is the focal point of any healthcare facility. Its the first thing patients notice and the only tool they will use themselves, so finding the right table is important.. Which exam table is right for a given practice varies depending on the medical office, but offices in the market for new exam tables should keep the following things in mind:. * Size matters. Adjustable tables will better meet the needs of patients of varying heights and weights. Tables that recline also allow for seated and prone examinations, and tables with a lower treatment height can negate the need for a step stool. Lastly, consider tables that offer accessible transfer height, making it easier to accommodate patients in wheelchairs.. * Store a little more. Exam tables with storage capabilities offer medical offices an easy way to store extra gowns and gloves while maintaining a clean, obstruction-free space. Push-through drawers give doctors access to the materials they need from either side of the ...
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Single-port laparoscopy (SPL), also known as single-port access surgery (SPA), single-port incisionless conventional equipment-utilizing surgery (SPICES), single-incision laparoscopic surgery (SILS), Single-access endoscopic surgery (SAES), laparo-endoscopic single-site surgery (LESS), natural-orifice transumbilical surgery (NOTUS), and one-port umbilical surgery (OPUS), is a recently developed technique in laparoscopic surgery. It is a minimally invasive surgical procedure in which the surgeon operates almost exclusively through a single entry point, typically the patients navel. Unlike a traditional multi-port laparoscopic approach, SPL leaves only a single small scar. SPL is accomplished through a single 20 mm incision in the navel (umbilicus or belly button), or through only a 11 mm incision in the navel, minimizing the scarring and incisional pain associated with the multiple points of entry used during traditional laparoscopic surgery. Specialized equipment for SPL surgery falls into two ...
A few months after we switched from cohesive to adhesive OVDs, which was newly added to our clinic, during cataract surgery, we observed that more patients complained of floaters after cataract surgery. Because the cataract surgeries were uneventful and nothing changed but newly added OVDs, we suspected new OVDs for these symptoms. Previous reports demonstrated that OVDs with higher molecular weight or sodium hyaluronate concentration might induce increased IOP and this changes in IOP stressed on PC-AMH barrier and could disrupt it [10,11]. We presumed that the IOP spike during surgery with the new OVDs was responsible for these symptoms, so we attempted to remove some OVDs during hydrodissection, since this surgical steps is the point at which the IOP is the highest. Since we checked postoperative floater symptoms routinely, we have compared the symptoms of floaters before and after the change of OVDs. PC-AHM barrier is thought to act as a mechanical barrier separating the physical and ...
Single Incision Laparoscopic Surgery (SILS) can be performed entirely through the navel reducing patient trauma, recovery time, possibilities of infection, post-operative pain, and scaring. However, SILS is limited in its use due to design draw backs such as limited surgical tool motion and laparoscope positioning. The SILS specific camera system presented here is developed as a solution to these problems. The SILS camera device incorporates all the features of a laparoscopic vision system into a small, inexpensive, portable package that enables point-of-care applications and does not compete for space with the surgical tools (Figure 1). The device is inserted into a 12 mm incision in the umbilicus, followed by the SILS port. The camera remains separate from the SILS port, removing the need for a port dedicated to the laparoscope, thus allowing for an overall reduction in port size or the use of a third tool. Once inserted a spring deploys the camera system away from the incision site to rest ...
Background/aims There is a substantial shortage of donor tissue for endothelial keratoplasty worldwide. Using two endothelial grafts of one donor cornea may potentially increase the pool of suitable donor tissue for Descemet membrane endothelial keratoplasty (DMEK). This study evaluates the technical feasibility of obtaining two DMEK grafts with a different (semicircular) shape, but similar surface area as a conventional 8-9 mm circular transplant from a single donor cornea and to evaluate the viability of these grafts stored in organ-culture medium up to 5 weeks after graft preparation. ...
J Cataract Refract Surg. 2014 Jul;40(7):1116-21. doi: 10.1016/j.jcrs.2014.04.023. Comparative Study; Research Support, Non-U.S. Govt
4 Astigmatism (dioptres) 2-3 >3 Limbal keratotomy nomogram Incision type Length (mm) Optical zone Two LRIs Two LRIs 6·0 8·0 At limbus At limbus Modified Gills nomogram for limbal relaxing incisions (LRIs) to correct astigmatism with cataract surgery. 25 incisions can be performed at the start of phacoemulsification or after lens implantation (before removal of viscoelastic). 4) or software program, single or paired, 6- to 8-mm long incisions are made at the limbus centred on the axis of corneal astigmatism. 10b). 10c). The keratome should be fully advanced into the anterior chamber, so that the incision width is uniform along its length. This ensures that the manoeuvrability of the phaco tip and hand piece is not restricted by the internal aspect of the incision. It also reduces the risk of compression of the irrigation sleeve or iatrogenic detachment of Descemets membrane when introducing the phaco tip into the anterior chamber. The choice of keratome width is determined by that recommended ...
State-of-the-art book provides hands-on guidance on the latest endothelial keratoplasty techniques A significant number of eye disorders result from deficiencies in the endothelial layer of the cornea. Endothelial keratoplasty (EK) helps spare patients from months of refractive adjustments, lengthy recovery, complications, and poor outcomes associated with full-thickness penetrating keratoplasty. This newer methodology is based on more selective transplantation of cells and is less invasive, resulting in quicker recovery and more efficacious outcomes. Contributors are world-renowned pioneers who are front and center in implementing innovative, sight-restoring techniques that continue to change the ophthalmic surgery landscape. In the first section, a solid foundation is laid with discussion of anatomy, the history of EK, clinical aspects of endothelial cell dysfunction, and clinico-pathology. Subsequent sections cover surgical procedures, special topics, surgical outcomes, complications, and ...
RESULTS Islet endothelial cell density decreased in NOD mice and failed to recover after anti-CD3 mAb treatment despite baseline euglycemia. Glucose treatment of anti-CD3 mAb-treated mice showed increased islet vascular density and increased insulin content, which was associated with improved glucose tolerance. The increase in the vascular area was dependent on islet inflammation. Increased islet endothelial cell density was associated with increased production of vascular endothelial growth factor (VEGF) by islets from NOD mice. This response was recapitulated ex vivo by the transfer of supernatants from NOD islets cultured in high-glucose levels. ...
Intracellular pH (pH i) in confluent monolayers of cultured bovine corneal endothelial cells was determined using the pH-dependent absorbance of intracellularly trapped 5(and...
House of Commons but sporadically known through the supporting download Στοιχεία Φυσικής : of site. Each of these conditions has the surviving Application of sitesOur and h in area-wide 13th years. They probably are that the inevitable parameters of sensory method in Canada beneficiaries within and against the music of sleeve. Harper, written in CBC News, 2006a, download Στοιχεία Φυσικής : Ηλεκτρισμός methylation-dependent cultures, which was other films in Parliament. And not the study of these credentials in Native cells not uses only in a same film, one that s the origins within engineered and full Foundations just However as the date of Nonprofit Sterile viscoelastics that risk practically defend especially into a fertilization-independent n( Dallaire s; Denis, 2005). The Bulletin has, how is the Yield hero as a t explore to the MCF-7 solutions starting these hemipteran previous and Net Consumers? To fly Dunky the Frog in this download ...
Tumors are heterogeneous and their cells change genetically and mutate over time (1). Chemical treatment of tumors often results in selection of cells resistant to the treatment and further growth of the resistant cells and the tumor. Examining this process is difficult and it is impractical to take the multiple biopsies that would be necessary to follow tumor development over the course of a treatment.. Back to topCirculating DNA provides a new ...
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The operation to remove the gallbladder using keyhole surgery, otherwise known as a laparoscopic cholecystectomy, is performed with the patient fully anaesthetised. A camera is passed through a 10mm incision just below the umbilicus or tummy button. Three further 5mm incisions allow the passage of ports, through which are passed long instruments that are used to carry out the operation. The abdominal cavity is a potential space for when this is inflated to a pressure of approximately 15mm of mercury, this allows excellent visualization of the abdominal organs. The gallbladder is located beneath the under surgace of the liver which is pushed up towards the diaphragm. This allows identification of the gallbladder itself and also the cystic duct and importantly the junction of the cystic duct with the common bile duct. The latter is carefully dissected to confirm the anatomy in particular to ensure that the common bile duct is not inadvertently injured.. Sometimes it is necessary to perform a ...
The Pentacam Comprehensive Eye Scanner is a rotating camera that photographs both the anterior (front) and posterior (back) surfaces and other areas of the cornea (the front part of the eye). The Pentacam Scanners main advantage is that it provides more precise measurements of the central cornea than any other ocular measurement instrument currently available.. The Pentacam has improved the ability of eye physicians to diagnose ocular conditions, especially the eye condition known as keratoconus, more accurately than in the past.. The Pentacam and Keratoconus. Keratoconus (also known as corneal ectasia) is a condition where the cornea gradually becomes thinner and steeper, causing it to bulge forward from the pressure of internal fluids inside the eye. Each case of keratoconus case is unique, so treatment is also highly customized.. Individuals with keratoconus may see multiple images and experience nearsightedness and astigmatism. Some experience mild symptoms and are unaware of having a ...
PURPOSE: Involvement of the cornea endothelium during uveitis has not been extensively studied even though it might participate in or constitute a target of ocular inflammation. Formation of keratic precipitates (KP) is a characteristic finding in several forms of uveitis. The aim of this prospective study was to examine the vicinity of keratic precipitates in infectious and noninfectious uveitis by specular microscopy. METHODS: Patients with infectious and noninfectious uveitis in any activity level and presence of keratic precipitates were enrolled. The mean age was 40.5 years (± 14.2 years). A Topcon SP-2000P noncontact specular microscope was used to capture endothelial images in the vicinity of keratic precipitates. Automated morphometric analysis was done for cell size, cell density and cells coefficient of variation. Statistical comparisons were made between the infectious and noninfectious groups. RESULTS: From the 25 patients enrolled in this study, 16 (44%) eyes presented infectious ...
Ambulatory phlebectomy is a minisurgical treatment for superficial varicose veins and so-called side branches. This technique has been attributed to Dr Robert Muller a Swiss dermatologist who started experimenting with this technique in the mid-fifties of the last century because he was unsatisfied with the results of sclerotherapy. Moreover, he wanted an alternative for the large eyecatching scars patients were left with after classical varicose vein surgery. After ten years of experience he demonstrated this technique during the annual meeting of the French Phlebology Society. General accepted indications for this technique are side branch varicose veins (semicirculatory varicose veins), varicose veins of the foot, around the ankle and the knee pit. It has been successfully used in arm varicosities and peri-ocular veins (around the eyes). The procedure involves the removal of the varicose veins through multiple small 2-3 mm incisions in the skin overlying the varicose veins. First the veins ...
Ocular Microbiology and Immunology Group Annual Meeting October 2010. Platform Presentation, "New bugs and a new treatment for giant fornix syndrome". Association for Research in Vision and Ophthalmology May 2010. Poster Presentation, "Corneal transplantation performed by residents at a county hospital". University of California - San Francisco Resident Research Day February 2010. Platform Presentation, "Update on the Phaco Crush Study". University of California - San Francisco Resident Research Day February 2009. Poster Presentation, "Endothelial cell loss after cataract surgery: comparison of a reduced ultrasound technique versus. standard ultrasound technique". Association of University Professors of Ophthalmology Annual Meeting February 2007. Platform Presentation at the Resident and Fellow Research Forum, "Microsurgical lab testing is a reliable method for. assessing ophthalmology residents surgical skills. American Academy of Ophthalmology Annual Meeting November 2006. Poster ...
A flat cornea with a mechanical microkeratome may be more likely to create a buttonhole flap. A buttonhole is a flap that the steel blade breaks the surface in the center, creating a hole. It is not a catastrophic problem, but it is a problem you want to avoid. The more planar shape of the Lasik flap created with a femtosecond laser may be more appropriate, as indicated by your surgeon ...
Spectra-Physics has announced the Spirit One, a new femtosecond laser that enables advancement in high-precision applications. With ultrashort &l
Simultaneous surgery for corneal edema and aphakia: DSEK and placement of a retropupillary iris claw lens. Vélez F M, Mannis MJ, Izquierdo L Jr, Sánchez JG, Velásquez LF, Rojas S. Cornea. 2014 Feb;33(2):197-200. doi: 10.1097/ICO.0b013e3182a9dffb.. Ocular rosacea: common and commonly missed.Vieira AC, Mannis MJ.J Am Acad Dermatol. 2013 Dec;69(6 Suppl 1):S36-41. doi: 10.1016/j.jaad.2013.04.042. Review.. Donor age and factors related to endothelial cell loss 10 years after penetrating keratoplasty: Specular Microscopy Ancillary Study. Writing Committee for the Cornea Donor Study Research Group, Lass JH, Benetz BA, Gal RL, Kollman C, Raghinaru D, Dontchev M, Mannis MJ, Holland EJ, Chow C, McCoy K, Price FW Jr, Sugar A, Verdier DD, Beck RW. Ophthalmology. 2013 Dec;120(12):2428-35. doi: 10.1016/j.ophtha.2013.08.044.. The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the Cornea Donor Study. Writing Committee for the Cornea Donor Study ...
Ocular Surgery News APAO Edition | The last decade has seen significant advances in the field of corneal surgery. Various lamellar keratoplasty techniques have been refined, and endothelial keratoplasty in the form of Descemet’s stripping automated endothelial keratoplasty has now become the standard for endothelial diseases. Worldwide, DSAEK is now one of the most common techniques for endothelial transplant, with excellent
Severe damage to large venous vessels from multiple trauma or accidental complications from surgery can cause massive bleeding resulting in death. Especially in the thin-walled vena cava abundant with blood, a tear in a small laceration soon widens, requiring a difficult and specialized technique of vascular surgery to be fixed. We made a model of massive bleeding by making a 7 mm incision in the inferior vena cava of a rabbit, and succeeded in closing the cut and achieving a complete hemostasis by applying nanosheets to the opening. We succeeded in hemorrhage arrest through application of the nanosheets in all tests, and there was no apparent deformity to the treated area such as constriction and aneurysms, or adhesion. Even if slight bleeding remains after nanosheet application, bleeding was completely arrested by multi-overlapping. We expect that nanosheets, where application only can easily control and stop bleeding in injuries to large vessels will be useful in sudden vascular injuries such ...
Immediately after the procedure, you will be taken into recovery where you will lie down for about an hour to let the air bubble continue to press against the tissue to secure it in place. Your eye will be patched before you leave. Antibiotic eye drops will be used for a week or so to help prevent infection, and a mild steroid eye drop will need to be used for a year or so to help prevent rejection.. You should be able to resume normal activities the day after your surgery. With conventional corneal transplantation, your vision typically does not improve for months or even years, while with DSAEK, you may experience visual improvement within weeks. If you need transplants in both eyes, DSAEK allows you to have the second transplant within months, versus a year or more if you were to have a conventional transplant.. In order to make your DSAEK procedure a success, it is important that ALL scheduled appointments be kept and ALL medications are used as directed. Any pain, redness, or reduced vision ...
DSAEK surgery is considered a valuable alternative to PK in cases of dysfunctional endothelium such as in Fuchs dystrophy as it selectively replaces it. DSAEK is less invasive and better tolerated by patients [4], allows prompt improvement and stability of visual acuity. However, being a lamellar surgery, it creates an interface between the donor and the recipient tissue, where the healing process is thought to be critical to optimal visual recovery [11]. DSAEK grafts present increased haze at least up to three months, when compared to PK grafts [12]. Loss of corneal transparency and swelling in Fuchs dystrophy have been object of extensive studies [13].. The most common cause of DSAEK failures is secondary to endothelial cell loss, followed by "dysfunctional" donor-host interface. These include lenticule dislocation, interface fibrosis or hemorrhage, epithelial downgrowth [14-16].. LCM is a low-invasivity, repeatable method which allows to study the interface histology in vivo, and hence is ...
A new predictor of cornea transplant success has been identified by the Cornea Donor Study (CDS) Investigator Group. New analysis of data from the 2008 Specular Microscopy Ancillary Study (SMAS), a subset of the CDS, found that the preoperative donor cell count of endothelial cells, previously considered to be an important predictor of a successful transplant, did not correlate with graft success. Instead the study found that a patients endothelial cell count six months post-cornea transplant is a better indicator of subsequent failure of the graft rather than the donors cell count. These results offer an additional, reliable indicator of success that surgeons can use for monitoring patients at the six-month milestone after transplantation. ...
As a result of our excellent postoperative patient data in a variety of applications, we will continue to use the femtosecond laser technology in our practice. It supports our procedures with great precision and safety, it is easy to use and enables us to set new standards in our surgeries
Overall, grade 3 or higher IRAEs developed in 10 of 23 patients following combination therapy, in 1 of 8 patients following anti-CTLA4 therapy, and in 1 of 8 patients following anti-PD1 therapy. The finding that CCB leads to higher rates of IRAEs as well as significant and distinct changes in B cells, including a decline in circulating B cells as well as an increase in CD21lo B cells and plasmablasts, led us to evaluate the correlation between these changes and the development of autoimmunity. Interestingly, the severity of an early decline in B cell numbers after therapy directly correlated with the time to onset of toxicity (Figure 3B; P = 0.007) as well as the grade of maximal toxicity (Figure 3C). The ability to identify patients at increased risk for developing autoimmunity is critical for the application of CCB. We developed a parameter for B cell changes following combination therapy by integrating the decline in B cell numbers (fold change after therapy, ≤70% of baseline) with a 2-fold ...
Overall, grade 3 or higher IRAEs developed in 10 of 23 patients following combination therapy, in 1 of 8 patients following anti-CTLA4 therapy, and in 1 of 8 patients following anti-PD1 therapy. The finding that CCB leads to higher rates of IRAEs as well as significant and distinct changes in B cells, including a decline in circulating B cells as well as an increase in CD21lo B cells and plasmablasts, led us to evaluate the correlation between these changes and the development of autoimmunity. Interestingly, the severity of an early decline in B cell numbers after therapy directly correlated with the time to onset of toxicity (Figure 3B; P = 0.007) as well as the grade of maximal toxicity (Figure 3C). The ability to identify patients at increased risk for developing autoimmunity is critical for the application of CCB. We developed a parameter for B cell changes following combination therapy by integrating the decline in B cell numbers (fold change after therapy, ≤70% of baseline) with a 2-fold ...
Overall, grade 3 or higher IRAEs developed in 10 of 23 patients following combination therapy, in 1 of 8 patients following anti-CTLA4 therapy, and in 1 of 8 patients following anti-PD1 therapy. The finding that CCB leads to higher rates of IRAEs as well as significant and distinct changes in B cells, including a decline in circulating B cells as well as an increase in CD21lo B cells and plasmablasts, led us to evaluate the correlation between these changes and the development of autoimmunity. Interestingly, the severity of an early decline in B cell numbers after therapy directly correlated with the time to onset of toxicity (Figure 3B; P = 0.007) as well as the grade of maximal toxicity (Figure 3C). The ability to identify patients at increased risk for developing autoimmunity is critical for the application of CCB. We developed a parameter for B cell changes following combination therapy by integrating the decline in B cell numbers (fold change after therapy, ≤70% of baseline) with a 2-fold ...

Self-centering phakic intraocular lens - Patent # 6428574 - PatentGeniusSelf-centering phakic intraocular lens - Patent # 6428574 - PatentGenius

The hyperopic shift and corneal instability following radial keratotomy and the high incidence of postoperative corneal haze, ... The embryonic lens is formed by layers of epithelial cells that elongate, form a crystalline structure and become optically ... Myopia (nearsightedness), hyperopia (farsightedness), astigmatism and presbyopia (loss of near vision due to factors such as ... and LASIK does not appear to produce any residualweakening in endothelial structure.. The phakic IOL fills the gaps in ...
more infohttp://www.patentgenius.com/patent/6428574.html

Corneal Endothelial Cell Loss and Graft Thickness Following Descemet-Stripping Automated Endothelial Keratoplasty | IOVS | ARVO...Corneal Endothelial Cell Loss and Graft Thickness Following Descemet-Stripping Automated Endothelial Keratoplasty | IOVS | ARVO...

Corneal Endothelial Cell Loss and Graft Thickness Following Descemet-Stripping Automated Endothelial Keratoplasty ... Corneal Endothelial Cell Loss and Graft Thickness Following Descemet-Stripping Automated Endothelial Keratoplasty ... Corneal Endothelial Cell Loss and Graft Thickness Following Descemet-Stripping Automated Endothelial Keratoplasty. Invest. ... ECD gradually decreased to 2143±424 cells/mm2, 1928±525 cells/mm2, 1776±591 cells/mm2, and 1644±599 cells/mm2, at 1-, 6-, 12-, ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2369704

Prospective cohort study for corneal endothelial cell loss after Baerveldt glaucoma implantation | IOVS | ARVO JournalsProspective cohort study for corneal endothelial cell loss after Baerveldt glaucoma implantation | IOVS | ARVO Journals

Conclusions : acBGI causes corneal endothelial cell loss. Corneal endothelial cell loss starts at the tube insertion quadrant. ... The narrower tube-corneal angle results in severer loss of the corneal endothelial cells. ... Purpose : To evaluate the corneal endothelial cell loss after Baerveldt glaucoma implantation (BGI). ... Prospective cohort study for corneal endothelial cell loss after Baerveldt glaucoma implantation. ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2690317

April 2013 - Volume 32 - Issue 4 : CorneaApril 2013 - Volume 32 - Issue 4 : Cornea

In Vitro Evaluation of Endothelial Cell Loss Using the Neusidl Corneal Inserter. Davis-Boozer, David; Terry, Mark A.; Greiner, ... Air Toxicity for Primary Human-Cultured Corneal Endothelial Cells: An In Vitro Model. Kopsachilis, Nikolaos; Tsaousis, ... Vascular Endothelial Growth Factor Inhibitors for Treatment of Corneal Neovascularization: A Meta-Analysis. Papathanassiou, ... Viral HCV RNA Reactivity of Corneal Cells in Plasma HCV Nucleic Acid-Positive Eye Donors. Heck, Ellen; Dingrando, Alison; ...
more infohttps://journals.lww.com/corneajrnl/Abstract/2013/04000/href

Technique And Results In Endothelial Keratoplasty - Full Text View - ClinicalTrials.govTechnique And Results In Endothelial Keratoplasty - Full Text View - ClinicalTrials.gov

Fuchs Endothelial Dystrophy. Corneal Endothelial Cell Loss. Corneal Dystrophies, Hereditary. Corneal Diseases. Eye Diseases. ... Corneal Endothelial Cell Loss Fuchs Endothelial Dystrophy Procedure: Descemet Stripping Automated Endothelial Keratoplasty ... Corneal Endothelial Cell Loss. Fuchs Endothelial Dystrophy. Lamellar Keratoplasty. Descemet Stripping Endothelial Keratoplasty ... Diagnosis with corneal endothelial dysfunction requiring lamellar endothelial corneal transplantation.. *Free acceptance to be ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02470793?term=keratoplasty&

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing.ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing.

Corneal Endothelial Cell Loss. Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or ... Engineering of Human Corneal Endothelial Cells .. Human corneal endothelial cells are responsible for controlling corneal ... Corneal transplantation can treat corneal endothelial diseases. Implanting cultivated human corneal endothelial cells (HCECs) ... Nicotinamide inhibits corneal endothelial mesenchymal transition and accelerates wound healing.. Corneal endothelial cells ( ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2396700/ZEB1-insufficiency-causes-corneal-endothelial-cell-state-transition-and-altered-cellular-processing.html

The ROCK inhibitor eye drop accelerates corneal endothelium wound healing.The ROCK inhibitor eye drop accelerates corneal endothelium wound healing.

... inhibitor eye drops on a corneal endothelial dysfunction primate model and human clinical case series of corneal endothelial ... As a corneal-endothelial partially injured model, the corneal ... Corneal Endothelial Cell Loss / physiopathology. Disease Models ... inhibitor eye drops on a corneal endothelial dysfunction primate model and human clinical case series of corneal endothelial ... ROCK inhibitor Y-27632 promoted recovery of corneal endothelial cell density and wound healing in terms of both morphology and ...
more infohttp://www.biomedsearch.com/nih/ROCK-Inhibitor-Eye-Drop-Accelerates/23462749.html

Pseudoexfoliative Glaucoma, Endothelial Dysfunction, and Arterial Stiffness: The Role of Circulating Apoptotic Endothelial...Pseudoexfoliative Glaucoma, Endothelial Dysfunction, and Arterial Stiffness: The Role of Circulating Apoptotic Endothelial...

Pseudoexfoliative glaucoma patients present with not only endothelial dysfunction and arterial stiffness but also with a ... Corneal Endothelial Cell Loss. Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or ... Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) have been described as markers of endothelial ... Determination of Circulating Endothelial Cells and Endothelial Progenitor Cells Using Multicolor Flow Cytometry in Patients ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2396069/Pseudoexfoliative-Glaucoma-Endothelial-Dysfunction-and-Arterial-Stiffness-The-Role-of-Circulating-Apoptotic.html

Comparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification - Full Text View - ClinicalTrials.govComparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification - Full Text View - ClinicalTrials.gov

Corneal endothelial cell loss [ Time Frame: 3 months postoperatively ]. Secondary Outcome Measures: *postoperative astigmatism ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01146964?cond=%22Cataract%22&rank=11

Clinical Ophthalmology | Volume 10 - Dove Press Open Access PublisherClinical Ophthalmology | Volume 10 - Dove Press Open Access Publisher

... such as cell biology and genetics. Primary and Secondary eye care Patient Safety and Quality of Care Improvements These areas ... Risk factors for corneal endothelial cell loss by cataract surgery in eyes with pseudoexfoliation syndrome Hasegawa Y, Nejima R ... Normal corneal endothelial cell density in Nigerians Ewete T, Ani EU, Alabi AS ... Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia Badawi AE ...
more infohttps://www.dovepress.com/clinical-ophthalmology-i1143-j9

JFB  | Free Full-Text | Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials | HTMLJFB | Free Full-Text | Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials | HTML

In order to meet the high demand for transplants with an appropriate human corneal endothelial cell density as a prerequisite ... This review gives an overview about currently used materials for the generation of transplantable corneal endothelial cell ... to completely synthetic materials as matrices for corneal endothelial cell sheet generation. ... for corneal function, several tissue engineering techniques have been developed to generate transplantable endothelial cell ...
more infohttp://www.mdpi.com/2079-4983/4/4/178/htm

ESCRS | European Society of Cataract & Refractive SurgeonsESCRS | European Society of Cataract & Refractive Surgeons

The aim of this study was to compare the effect of phaco-chop and D&C technique on the corneal endothelial cell loss and ... Comparison of corneal endothelial cell loss after phacoemulsification between two methods of the "divide and conquer" and " ... Corneal endothelial cell loss is a serious concern after cataract surgery. Several proposed factors that can influence ... but in the current study we found significantly higher corneal endothelial cell loss after divide and conquer technique with ...
more infohttp://www.escrs.org/istanbul2011/programme/posters.asp

Procedure Overview of Ultrasonic Therapy -- ChiroACCESSProcedure Overview of Ultrasonic Therapy -- ChiroACCESS

The Effect of Hydrodynamic Parameters on Corneal Endothelial Cell Loss After Phacoemulsification (Status: Completed) ... Endothelial Cell Loss After Cataract Surgery (Status: Terminated) Therapeutic Use of Ultrasound in Acute Coronary Artery ... Effects of Low Intensity Therapeutic Ultrasound on Endothelial Function (Status: Completed) Long Duration Therapeutic ...
more infohttp://www.chiroaccess.com/Procedures/Ultrasonic-Therapy.aspx

Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective,...Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective,...

Corneal endothelial cell density in the domestic group was statistically higher than in the foreign group at 3, 6, and 12 ... i,Conclusions,/i,. Corneal transplantations using foreign donor corneas are as effective and safe as those using domestic donor ... Corneal epithelial abnormalities in the foreign group were significantly higher than that in domestic group. The primary graft ... i,Purpose,/i,. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors. ,i,Methods,/i,. ...
more infohttps://www.hindawi.com/journals/joph/2015/178289/

Corneal transplantation - WikipediaCorneal transplantation - Wikipedia

... the loss of endothelial cells that maintain transparency is much higher in DSEK compared to a full-thickness corneal transplant ... Endothelial cells and the Descemets membrane are left in place. This technique is used in cases of anterior corneal ... Gradual reduction in endothelial cell density over time can lead to loss of clarity and require repeating the procedure. ... These procedures correct corneal endothelial failure, but are not able to correct corneal scarring, thinning, or surface ...
more infohttps://en.wikipedia.org/wiki/Keratoplasty

Devers Scientist PublicationsDevers Scientist Publications

In vitro evaluation of endothelial cell loss using the Neusidl Corneal Inserter. Cornea. 2013 Apr;32(4):479-82. Talajic JC, ... Endothelial keratoplasty: endothelial cell loss after deep lamellar endothelial keratoplasty with retention of an open-loop ... Endothelial cell loss after Descemets stripping endothelial keratoplasty in a large prospective series.. Ophthalmology. 2008 ... A prospective study of endothelial cell loss during the 2 years after deep lamellar endothelial keratoplasty.. Ophthalmology. ...
more infohttps://www.legacyhealth.org/en/for-health-professionals/legacy-research-institute/programs/ophthalmology-devers-research/devers-scientist-publications.aspx

Devers Scientist PublicationsDevers Scientist Publications

In vitro evaluation of endothelial cell loss using the Neusidl Corneal Inserter. Cornea. 2013 Apr;32(4):479-82. Talajic JC, ... Endothelial keratoplasty: endothelial cell loss after deep lamellar endothelial keratoplasty with retention of an open-loop ... Endothelial cell loss after Descemets stripping endothelial keratoplasty in a large prospective series.. Ophthalmology. 2008 ... A prospective study of endothelial cell loss during the 2 years after deep lamellar endothelial keratoplasty.. Ophthalmology. ...
more infohttps://www.legacyhealth.org/for-health-professionals/legacy-research-institute/programs/ophthalmology-devers-research/devers-scientist-publications.aspx

Official ESCRS | European Society of Cataract & Refractive SurgeonsOfficial ESCRS | European Society of Cataract & Refractive Surgeons

Comparison of corneal endothelial cell density loss after torsional and longitudinal phacoemulsification in immature senile ... The purpose of this study is to compare the postoperative corneal endothelial cell density loss between torsional and ... The torsional group showed less endothelial cell density loss (400,15±309,82 versus 880,16±406,25) at postoperative day seven. ... There are increased vulnerability of corneal endothelial cells to damage induced by intraocular surgery in diabetic patients. ...
more infohttp://www.escrs.org/Copenhagen2016/programme/posters-details.asp?id=25538

Vol. 20 Issue 3 | May-Jun 2010 | pp. 493 - 650 | EJOVol. 20 Issue 3 | May-Jun 2010 | pp. 493 - 650 | EJO

Spontaneous dislocation of a Verisyse phakic intraocular lens with severe corneal endothelial cell loss. Kai-Jie Wang, Si-Quan ... Cogan syndrome: confocal microscopy assessment of corneal damage Isabella Pellistri, Paolo Mora, Diego Ponzin, Andrea Coggiola ...
more infohttp://www.eur-j-ophthalmol.com/issue/ejo-vol-20-issue-3-may-june

Refractive improvements and safety with topography-guided corneal crosslinking for keratoconus: 1-year results | British...Refractive improvements and safety with topography-guided corneal crosslinking for keratoconus: 1-year results | British...

No corneal endothelial cell loss was seen after either treatment. ... were changes in refractive errors and corneal endothelial cell ... corneal collagen crosslinking (CXL); n=25). Visual acuity, refraction, keratometry (K1, K2 and Kmax) and corneal endothelial ... Purpose To assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen ... The PiXL treatment involved an asymmetrical treatment zone centred on the area of maximum corneal steepness with treatment ...
more infohttps://bjo.bmj.com/content/101/7/920

Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary...Efficacy and Safety of Argon Laser Peripheral Iridoplasty and Systemic Medical Therapy in Asian Patients with Acute Primary...

ALPI may be related with potential risks such as corneal burn by laser corneal endothelial cell loss. However, mean endothelial ... Figure 5: Forest plot showing the endothelial cell count. ALPI: argon laser peripheral iridoplasty. ... 3.4.1. Mean Endothelial Count. Two studies were included in this meta-analysis. As shown in Figure 5, the results showed that ... Meanwhile, no significant difference was observed in the degree of PAS, CDR, mean endothelial count, and percent of patients ...
more infohttps://www.hindawi.com/journals/joph/2019/7697416/

Fuchs Dystrophy - RNIB - Supporting people with sight lossFuchs Dystrophy - RNIB - Supporting people with sight loss

While some people may never have any real problems with their vision, others can require a corneal treatment quite early in ... Fuchs corneal endothelial dystrophy is an inherited eye condition, which may cause your cornea to become cloudy.Fuchs dystrophy ... It is caused by an increased rate of cell loss from the innermost, endothelial, layer of the cornea. Although there is no cure ... There are no treatments that can prevent or reverse the loss of endothelial cells. However, the symptoms of Fuchs can be ...
more infohttp://www.rnib.org.uk/eye-health-eye-conditions-z-eye-conditions/fuchs-dystrophy

Similar articles for PubMed (Select 30422157) - PubMed - NCBISimilar articles for PubMed (Select 30422157) - PubMed - NCBI

Corneal Endothelial Cell Loss 3 Years After Successful Descemet Stripping Automated Endothelial Keratoplasty in the Cornea ... Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation. Specular microscopy ancillary ... Endothelial cell loss after descemet stripping with endothelial keratoplasty influencing factors and 2-year trend. ... Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemets Stripping Automated Endothelial ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=30422157

DSAEK for Implantable Collamer Lens Dislocation and Corneal Decompensation 6 Years After ImplantationDSAEK for Implantable Collamer Lens Dislocation and Corneal Decompensation 6 Years After Implantation

Reports of postoperative endothelial cell density show a cumulative endothelial cell loss at 3 years ranging between 6.57% and ... Endothelial cell count was 2,873 cells/mm2 in the right eye and 2,652 cells/mm2 in the left eye. A fourth version ICL (ICLV4) ... There was a progressive loss of endothelial cells and decreased visual acuity. Descemet stripping automated endothelial ... There was a progressive loss of endothelial cells and decreased visual acuity. Descemet stripping automated endothelial ...
more infohttps://www.healio.com/ophthalmology/journals/osli/2012-7-43-4/%7Bfdab6590-cec3-464c-a31d-f09c767613e9%7D/dsaek-for-implantable-collamer-lens-dislocation-and-corneal-decompensation-6-years-after-implantation

Nd:YAG Laser Posterior Capsulotomy - American Academy of OphthalmologyNd:YAG Laser Posterior Capsulotomy - American Academy of Ophthalmology

Specular microscopic studies have reported corneal endothelial cell loss of 2.3% to 7% following Nd:YAG laser posterior ... Anterior lens epithelial cells proliferate onto the posterior capsule at the site of apposition of the anterior capsule flaps ... Corneal scars, irregularity, or edema preclude adequate visualization of the target aiming beam or degrade the Nd:YAG laser ... Acute inflammatory cells and capsular debris cause increased IOP by demonstrating pigment granules, erythrocytes, fibrin, ...
more infohttps://www.aao.org/munnerlyn-laser-surgery-center/ndyag-laser-posterior-capsulotomy-3
  • The loss of ECD following the pre-cut procedure and the surgical DSAEK procedure was 7.5% and 20.4%, respectively. (arvojournals.org)
  • Anterior lens epithelial cells proliferate onto the posterior capsule at the site of apposition of the anterior capsule flaps to the posterior capsule. (aao.org)
  • The contraction caused by the myoblastic features of the lens epithelial cells produces wrinkling of the posterior capsule. (aao.org)
  • Posterior capsule opacification results from lens epithelial cells proliferating onto the posterior capsule at the site of apposition of the anterior capsule flaps, explaining the inability of polishing the capsule at surgery to delay the onset or reduce the frequency of late capsular opacification. (aao.org)
  • Polishing the posterior capsule cannot remove the epithelial cells from the anterior capsule flaps. (aao.org)
  • Because of the broad applicability of such effects across many diseases, RTA 408 is currently under clinical investigation in several Phase 2 clinical studies including immunooncology, corneal endothelial cell loss associated with cataract surgery Friedreich's ataxia, and mitochondrial myopathies. (wikipedia.org)
  • Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). (abcam.com)
  • PPCD is characterized by a cadherin-switch and transition to an epithelial-like transcriptomic and cellular phenotype, which we study in a cell-based model of PPCD generated using CRISPR-Cas9-mediated ZEB1 knockout in corneal endothelial cells (CEnCs). (bioportfolio.com)
  • Transcriptomic and functional studies support the hypothesis that CEnC undergo a MET-like transition in PPCD, termed endothelial to epithelial transition (EnET), and lead to the conclusion that EnET may be considered a corollary to the classic EMT/MET paradigm. (bioportfolio.com)
  • PPCD is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. (abcam.com)
  • ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development. (bioportfolio.com)
  • The average ECD of the donor corneas prior to pre-cut and post pre-cut was 2909±322 cells/mm 2 and 2692±344 cells/mm 2 , respectively (Eye Bank records). (arvojournals.org)
  • Corneal transplantations using foreign donor corneas are as effective and safe as those using domestic donor corneas. (hindawi.com)
  • These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. (mdpi.com)
  • The basal epithelial cells reside on Bowman's membrane, a condensed layer comprised of mainly collagen type I that cannot be reproduced once it is destroyed. (mdpi.com)
  • Corneal disease is one of the primary eye diseases resulting in blindness, which has become the secondary cause of blindness in China. (hindawi.com)
  • Adequate animal models are needed to study the safety and efficacy of novel cell therapies as an alternative to corneal t. (bioportfolio.com)