Corneal Neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Eye Burns: Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.Burns, ChemicalAngiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Retinal Neovascularization: Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.Antigens, CD31: Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.Choroidal Neovascularization: A pathological process consisting of the formation of new blood vessels in the CHOROID.Fibroblast Growth Factor 2: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).Injections, Intraocular: The administration of substances into the eye with a hypodermic syringe.Alkalies: Usually a hydroxide of lithium, sodium, potassium, rubidium or cesium, but also the carbonates of these metals, ammonia, and the amines. (Grant & Hackh's Chemical Dictionary, 5th ed)Angiogenesis Inducing Agents: Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Ophthalmic Solutions: Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Mice, Inbred C57BLDisease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Vascular Endothelial Growth Factors: A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.Keratitis: Inflammation of the cornea.Cautery: The application of a caustic substance, a hot instrument, an electric current, or other agent to control bleeding while removing or destroying tissue.Endothelial Growth Factors: These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.Eye Injuries: Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Epithelium, Corneal: Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.Lymphokines: Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.Corneal Stroma: The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.Vascular Endothelial Growth Factor Receptor-2: A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.Corneal Opacity: Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Endostatins: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.Thrombospondin 1: An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.Retinal Vessels: The blood vessels which supply and drain the RETINA.Keratitis, Herpetic: A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.Vascular Endothelial Growth Factor Receptor-1: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.Mice, Inbred BALB CRabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Receptors, Vascular Endothelial Growth Factor: A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Keratoplasty, Penetrating: Partial or total replacement of all layers of a central portion of the cornea.Wound Healing: Restoration of integrity to traumatized tissue.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Corneal Diseases: Diseases of the cornea.

*Aganirsen

... in progressive corneal neovascularisation in patients suffering from infectious keratitis and on the waiting list for Corneal ... "Downregulation of IRS-1 expression causes inhibition of corneal angiogenesis" Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4072-8 ... including progressive corneal neovascularization in patients suffering from infectious keratitis and wet age related macular ... "GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial" ...

*Neovascularization

... is conventionally distinguished from angiogenesis in that angiogenesis is mainly characterized by the ... Choroidal neovascularization Corneal neovascularization Revascularization Rubeosis iridis Rucker, Martin; Laschke, Matthias W ... Neovascularization in the eye can cause a type of glaucoma (neovascularization glaucoma) if the new blood vessels' bulk blocks ... Neovascularization is the natural formation of new blood vessels (neo- + vascular + -ization), usually in the form of ...

*Proteases in angiogenesis

Kato, T; Kure, T; Chang, JH; Gabison, EE; Itoh, T; Itohara, S; Azar, DT (2001). "Diminished corneal angiogenesis in gelatinase ... indicating impaired neovascularization. Neovascularization also is impaired in mice treated with bone marrow derived cells ... Both enzymes inhibit bFGF induced vascularization in the corneal pocket assay and inhibit VEGF induced angiogenesis in the ... For example, MMP-2 knockout mice develop normally but display significant inhibition of corneal angiogenesis. Numerous ...

*Rubeosis iridis

... choroidal neovascularization) CNV (corneal neovascularization) NVD (neovascularization of the disc) NVE (neovascularization ... These factors stimulate the formation of new blood vessels (angiogenesis). Unfortunately, these new vessels do not have the ... Once the neovascularization has been longstanding, the new vessels recruit fibrous tissue, and as this forms and contracts, the ... Rubeosis iridis, also called neovascularization of the iris (NVI), is a medical condition of the iris of the eye in which new ...

*Perlecan

A similar result was produced in the corneal micropocket assay, where FGF-2 is implanted into the cornea of mice and in normal ... Zhou Z, Wang J, Cao R, Morita H, Soininen R, Chan KM, Liu B, Cao Y, Tryggvason K (July 2004). "Impaired angiogenesis, delayed ... While Perlecan suppression causes substantial inhibition of tumor growth and neovascularization in null mice, in contrast, when ... Corneal opacification occurred in both transgenic lines early in development due to greatly increased expression of perlecan, ...

*CYR61

... has potent angiogenic activity upon endothelial cells and induces neovascularization, first demonstrated in a corneal ... Angiogenesis is essential for the supply of oxygen and nutrients to nourish the growing tumor. CYR61 is a powerful angiogenic ... Folkman J (2006). "Angiogenesis". Annu. Rev. Med. 57: 1-18. doi:10.1146/annurev.med.57.121304.131306. PMID 16409133. Monnier Y ... promotes angiogenesis and tumor growth". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6355-6360. doi:10.1073/pnas.95.11.6355. PMC ...

*Prostaglandin EP4 receptor

This result suggests that EP4 activation contributes to corneal neovascularization and that EP4 antagonists may be useful for ... and angiogenesis. EP4 activation of G proteins also activate PI3K/AKT/mTOR, ERK, and p38 MARK pathways. Activation of ERK ... A selective EP4 antagonists significantly reduced corneal neovascularization in rats caused by oxygen-induced retinopathy or ... corneal endothelium, corneal keratocytes, trabecular cells, ciliary epithelium, conjunctival stromal cells, and iridal stromal ...

*Stem-cell therapy

Hematopoietic stem cells have been used to treat corneal ulcers of different origin of several horses. These ulcers were ... "Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces ... This is thought to be due, in part, to improved angiogenesis and reduction of inflammation. Although cardiomyocytes were ... Since 2003, researchers have successfully transplanted corneal stem cells into damaged eyes to restore vision. "Sheets of ...

*Cord factor

... of Mycobacterium tuberculosis Induces Corneal Angiogenesis in Rats". Infection and Immunity. 68 (10): 5991-5997. doi:10.1128/ ... enhances neovascularization through vascular endothelial growth factor production by neutrophils and macrophages". Infection ... which is important for angiogenesis, a step in granuloma formation. The granulomas can be formed either with or without T-cells ...
Purpose: : To evaluate the effect of topically administered diclofenac, ketorolac, and etanercept on experimental corneal neovascularization. Methods: : Chemical cauterization of the cornea in 32 eyes of 32 rats was performed using silver nitrate sticks to induce corneal neovascularization. Topical instillation of diclofenac (Volteran, Novartis Pharmaceuticals), ketorolac (Acular, Allergan), and etanercept (Enbrel, Immunex Corp.) was compared to normal saline treatment for inhibition of neovascularization for 7 days. All animals were treated in accordance with the ARVO guidelines on the care and use of animals in research. The animals were randomly divided in 4 groups. Group 1 (n=8) received balanced salt solution (control), group 2 (n=8) received ketorolac 0.5 %, group 3 (n=8) received diclofenac 0.1%, and group 4 (n=8) received 200 µg/ml of etanercept. Percentage area of cornea covered by ...
The purpose of the study is to test the investigational drug Gamunex-C on the growth of blood vessels over the cornea. This study is being conducted by Dr. Balamurali Ambati at the Moran Eye Center at the University of Utah.. The cornea is the clear outer front part of the eye. In corneal neovascularization, blood vessels grow over the cornea. Corneal neovascularization and ocular anterior segment inflammations are sight-threatening conditions. Lipid deposition and edema with subsequent scar formation can compromise corneal clarity irreversibly. Corneal neovascularization is also a well recognized risk factor for corneal graft failure. In its natural state, the cornea is a site of immune privilege well suited to tissue transplantation. Once vascularized, there is direct exposure of ...
Purpose: : To investigate human cornea proteome. The human cornea is composed of several layers interacting in a complex manner and possessing specific functions, like eye protection and optical clearness. Only few proteomic studies of mammalian cornea have been performed leading to the identification of less than 200 proteins in human corneas. Methods: : The present study explores the proteome of the intact normal human cornea using a shot-gun nanoLC-MS/MS strategy and an LTQ Orbitrap mass spectrometer. Results: : A total of 2070 distinct corneal proteins were identified from five human cornea samples, which represents a 14-fold improvement in the number of proteins identified so far for human cornea. Network and gene ontology analyses were used to determine biological pathways specific of the human cornea. They allowed the identification of subnetworks of putative importance for corneal diseases, like a redox regulation and oxidative ...
Purpose : The cornea efficiently restricts permeability of topically administered drugs into the eye. Currently, permeability of drug candidates is tested across excised animal corneas ex vivo or using in vitro cell culture models. The purpose of this study was to develop an artificial cornea for drug permeability screening in early drug development that more adequately resembles the human cornea. Methods : Several modifications of artificial corneas were prepared using different hydrogel cross-linking and coating techniques. The apparent permeability coefficient (Papp) values of standard reference molecules across artificial corneas were tested using Navicyte vertical diffusion chambers. Permeability characteristics (tightness, dynamic range) of the artificial cornea was assessed, and the Papp values across artificial cornea were correlated with those of ex vivo rabbit corneas and in vitro human corneal epithelial cell (HCE-T) culture model. HCE-T cells were also grown on ...
Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into avascular corneal tissue as a result of oxygen deprivation. Maintaining avascularity of the corneal stroma is an important aspect of corneal pathophysiology as it is required for corneal transparency and optimal vision. A decrease in corneal transparency causes visual acuity deterioration. Corneal tissue is avascular in nature and the presence of vascularization, which can be deep or superficial, is always pathologically related. Corneal neovascularization is a sight-threatening condition that can be caused by inflammation related to infection, chemical injury, autoimmune ...
Artificial cornea Suppliers, Artificial cornea Manufacturers, Artificial cornea Exporters and Artificial cornea Business Leads from the technical textile industry worldwide - TechnicalTextile.net
PURPOSE OF REVIEW:. Artificial corneas are being developed to meet a shortage of donor corneas and to address cases in which allografting is contraindicated. A range of artificial corneas has been developed. Here we review several newer designs and especially those inspired by naturally occurring biomaterials found with the human body and elsewhere.. RECENT FINDINGS:. Recent trends in the development of artificial corneas indicate a move towards the use of materials derived from native sources including decellularized corneal tissue and tissue substitutes synthesized by corneal cells in vitro when grown either on their own or in conjunction with novel protein-based scaffolds. Biologically inspired materials are also being considered for implantation on their own with the view to promoting endogenous corneal tissue.. SUMMARY:. More recent attempts at making artificial corneas have taken a more nature-based or ...
Full thickness corneal transplant. Your entire cornea may need to be replaced if both the front and inner corneal layers are damaged. This is called penetrating keratoplasty (PK), or full thickness corneal transplant. Your diseased or damaged cornea is removed. Then the clear donor cornea is sewn into place.. PK has a longer recovery period than other types of corneal transplants. Getting complete vision back after PK may take up to 1 year or longer.. With a PK, there is a slightly higher risk than with other types of corneal transplants that the cornea will be rejected. This is when the bodys immune system attacks the new cornea tissue.. Partial thickness corneal transplant. Sometimes the front and middle layers of the cornea are damaged. In this case, only those layers are removed. The endothelial layer, ...
The corneas of people with glaucoma seem to exhibit different qualities than those who do not suffer from this condition.. A French study determines that corneas of patients with glaucoma are more likely to be less elastic and lose their proper shape than healthy corneas. The researchers assessed the condition of almost 500 eyes with and without glaucoma and found that the eyes of patients with glaucoma tended to have a higher corneal resistance factor (CRF) and lower corneal hysteresis (CH) - both signs of poor corneal biomechanics.. Corneal resistance refers to the flexibility or none flexibility of the cornea - a higher factor means that the cornea is less flexible. I higher factor means that the cornea is less flexible.. Corneal hysteresis refers to the ability of the cells comprising the cornea to to absorb and scatter energy. A lower ...
PURPOSE To report the outcomes of corneal fine needle diathermy (FND) with adjuvant intrastromal and subconjunctival bevacizumab injection for corneal neovascularization (CN) in children. METHODS Medical records of all children who had undergone FND with adjuvant bevacizumab injection were reviewed retrospectively. Treatment efficacy was evaluated by changes in visual acuity, regression of CN, and clearing of lipid deposits with the aid of slit-lamp color images that were taken before surgical intervention and at last follow-up visit. Postoperative complications were recorded and served to assess the safety of the procedure. RESULTS Nine eyes of 9 patients were included in the study. The mean age of the patients was 8.4 ± 4.2 years (4-15 years) and the mean follow-up time was 18.7 ± 12.2 months (5-35 months). Three eyes had a history of herpes simplex keratitis (HSK), 3 eyes had complete ...
Looking for online definition of Slit-Lamp Biomicroscopy in the Medical Dictionary? Slit-Lamp Biomicroscopy explanation free. What is Slit-Lamp Biomicroscopy? Meaning of Slit-Lamp Biomicroscopy medical term. What does Slit-Lamp Biomicroscopy mean?
This is a more recently developed procedure that involves only replacing the innermost layers of the cornea rather than the whole cornea as in penetrating keratoplasty. In conditions such as Fuchs endothelial dystrophy, the innermost layer called the endothelium is diseased. This results in swelling of the cornea causing decreased vision. Previously to replace the valuable endothelial layer the whole central cornea was replaced by performing a Penetrating Keratoplasty. With innovative techniques, we are now able to replace just the innermost layer.. The procedure involves peeling off the inner two layers of the diseased cornea. A donor cornea is then split or dissected to create a flap of the inner two layers and a small portion of stroma (to provide substance for manipulation). This 3 layer donor is then folded and inserted into the eye. It is then unfolded and lifted up against the patients cornea using an air bubble. The air bubble is then left in the eye to hold the donor cornea in ...
Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization.. In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). Among available treatments, anti-VEGF often shows limited or temporary efficacy, while steroids are potentially responsible for many side-effects. This thesis presents a series of linked studies aimed at elucidating the early pathologic changes leading to inflammation and corneal neovascularization, and how various treatments affect this process. In this thesis, anti-inflammatory and anti-angiogenic treatments are applied in corneal neovascularization models, to identify VEGF-independent ...
Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.
TY - JOUR. T1 - Monitoring of rabbit cornea response to dehydration stress by optical coherence tomography. AU - Hosseini, Kamran. AU - Kholodnykh, Alexander I.. AU - Petrova, Irina Y.. AU - Esenaliev, Rinat O.. AU - Hendrikse, Fred. AU - Motamedi, Massoud. PY - 2004/8/1. Y1 - 2004/8/1. N2 - PURPOSE. To evaluate the application of optical coherence tomography (OCT) for continuous noninvasive monitoring and quantification of the dynamics of corneal response after exposure of the cornea to dehydrating stress. METHODS. The changes in central corneal thickness (CCT) and scattering properties of the cornea were monitored with OCT in rabbit cornea in vivo after topical application of a glycerin-based hypertonic agent (HA) or prolonged surface evaporation of the cornea. The observed changes in backscatter were correlated with the changes in corneal hydration. RESULTS. An inverse relationship was found between the ...
The results from this research may open the door to future therapeutics for a myriad of corneal disorders. "It is essential to know the biochemical composition of normal healthy corneas in the effort to understand the molecular mechanisms behind corneal disorders," emphasizes Dr. Enghild. "By comparative proteomic studies of diseased and normal corneas we can identify differences in the expression profiles that may suggest avenues for therapeutic interventions. Because the cornea is so accessible, the potential for developing effective drugs for the treatment of corneal diseases is good. Furthermore, the work is likely to improve the clinical classifications of corneal diseases. Identification of the protein profile of the normal human cornea may also be very useful in the effort toward generating artificial corneas for transplantation ...
PURPOSE: To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity. METHODS: One hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) ...
3D printed spectacles for corrective vision. A keratoconus-affected cornea loses its natural roundness and bulges out to form a cone-like shape. The light entering the eye to the retina is deflected which is the cause of distorted vision. According to the Royal National Institute of Blind People (RNIB), keratoconus affects 1 in 2,000 people in Britain and is more common in South Asian people. Dr. Hongxin explained that a blueprint of a patients cornea can be used to fully customize the 3D printed spectacles to fit corneas of different shapes. This will correct the distortion of the eye-sight. "Normal corneas have a smooth and convex surface, while their [keratoconus patients] corneas are bumpy with many irregular concaves," Dr Hongxin told Beijing News. Inspired by NASA Dr. Hongxin says the 3D printed spectacles for cornea patients were inspired by NASAs adaptive optics technology (AO). NASA uses adaptive optics to improve its telescopes image quality which is distorted by the Earths ...
TY - JOUR. T1 - Correlative transmission electron microscopy and scanning electron microscopy of rabbit cornea. AU - Fauziah, O.. AU - Siti-Saleha, M.. AU - Abd. Ghafar, Norzana. AU - Asmah, R.. AU - Aminuddin, S.. AU - Idrus, Ruszymah. PY - 2010. Y1 - 2010. N2 - The present work was carried out to study the organization of rabbit cornea. The transparent nature of the normal cornea was very important to give the understanding of the cornea in health and disease state. The ultrastructural features of the cornea were obtained by transmission electron microscopy and scanning electron microscopy. The epithelial surface of the cornea composed of microvilli and microplicae. In the Bowmans membrane, the individual collagen fibrils were interwoven densely to form a felt-like sheet, while in the stroma, the collagen fibrils ran abreast in lamellae. In the innermost stromal region adjacent to Descemets membrane, collagen fibrils were oriented in various directions and interlaced, forming loose fibrillar ...
We evaluated the corneal biomechanical properties in a population of healthy children in China. As far as we know, this is the first report of quantitative assessment of the corneal biomechanics in children population using CST. We used the newly updated CST software, which provided two more parameters (A1DA and A2DA) than previous versions. This helped to measure corneal deformation more comprehensively. We also assessed the symmetry of corneal biomechanics between the both eyes and found obviously interocular symmetry in SE, CCT, IOP, and corneal biomechanics in healthy children eyes. We also found that several CST biomechanical parameters in children are modified by CCT and IOP, while age, SE, and sex exert little influence on the CST measurements in this population.. Our observations of interocular symmetric biometry were consistent with ...
The traditional corneal transplant surgery involves removing the diseased or damaged tissue from you reye and replacing it with the healthy donor tissue. The entire operation is done under a surgical microscope. You will be asleep during the procedure and therefore will not feel any pain.. Most of the diseased cornea is removed surgically after using a circular blade (trephine) to cut into the cornea. This is then removed by using corneal micro-scissors. A similar procedure is performed on the donor cornea and the donor disc which is similar in size to the cornea that was removed is used to replace the patients cornea with healthy donor tissue. The donor cornea is held in place with very fine stitches using suture material that is usually thinner than the human hair.. The newer corneal transplant procedures only replace the diseased part of the cornea with a similar healthy layer of donor ...
The cornea is the translucent part of the eye that covers the anterior portion of the eye. It covers the pupil, iris, and anterior chamber (fluid-filled inside of the eye). Its function is to refract, or bend, light. It is composed of proteins and cells. It does not contain blood vessels. Some of the blood vessels may cloud the cornea and prevent it from refracting light properly and adversely affect vision. The cornea inclines to repair itself quickly from minor abrasions but deeper abrasions may cause scars to form on the cornea that causes the cornea to lose its transparency, leading to visual impairment.. Cornea displaces depending on the disease that is causing vision problems. For example, Fuchs dystrophy only have a problem with the back layer of the cornea and require single cell layer from donor cornea in a procedure known as DMEK. Others conditions such as Keratoconus, the disease only affects the front part of the cornea, only that diseased portion is replaced in a procedure known as ...
Clinical applications of corneal confocal microscopy Mitra Tavakoli1, Parwez Hossain2, Rayaz A Malik11Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, UK; 2University of Southampton, Southampton Eye Unit, Southampton General Hospital, Southampton, UKAbstract: Corneal confocal microscopy is a novel clinical technique for the study of corneal cellular structure. It provides images which are comparable to in-vitro histochemical techniques delineating corneal epithelium, Bowman’s layer, stroma, Descemet’s membrane and the corneal endothelium. Because, corneal confocal microscopy is a non invasive technique for in vivo imaging of the living cornea it has huge clinical potential to investigate numerous corneal ...
Corneal Transplant Surgery. The cornea is the clear covering of the front of the eye which bends, or refracts, light rays as they enter the eye. For clear vision to occur, the cornea must have the correct shape and clarity to focus incoming light rays precisely on the retina at the back of the eye. When the cornea becomes cloudy or misshapen from injury, infection or disease, transplantation may be recommended to replace it.. Corneal transplants are usually performed with local anesthesia so there is no pain. During the procedure, the cornea is replaced with one from a human donor. The new cornea carries little risk of rejection and can last for many years.. DSEK Surgery. DSEK is the latest technique in corneal transplantation. Short for Descemet-stripping automated endothelial keratoplasty, DSEK offers clear post-operative vision and short recovery time to patients in need of new corneas.. During the ...
PURPOSE. The authors investigated the phenotypic characteristics of basally located transitional cells in peripheral superior cornea, characterized previously by their coexpression of cytokeratin 19 and vimentin and their negativity for AE5. METHODS. Twenty adult human corneas were studied, using in situ immunohistochemical techniques and a panel of specific monoclonal antibodies against various surface and cytoplasmic molecules. RESULTS. The transitional cells shared staining characteristics with limbal basal cells in their expression of alpha 6 beta 4-integrin, metallothionein, AE1, and transferrin receptor. CONCLUSIONS. These transitional epithelial cells exhibit a unique phenotype differing from that of the surrounding basal epithelial cells in the peripheral cornea but analogous to that of limbal basal cells. These findings further corroborate the hypothesis that, at least from an immunohistochemical point of view, transitional cells in the superior peripheral cornea exhibit stem cell ...
TY - JOUR. T1 - Quantitative assessment of anteroposterior keratocyte density in the normal rabbit cornea. AU - Petroll, W. M.. AU - Boettcher, K.. AU - Barry, P.. AU - Cavanagh, D.. AU - Jester, J. V.. PY - 1995. Y1 - 1995. N2 - The anteroposterior keratocyte density distribution in the rabbit cornea was measured. Unsectioned tissue blocks from the central cornea of five rabbits were stained with propidium iodide and imaged using a Leica laser scanning confocal microscope. A z-series of images was acquired in each sample, from anterior to posterior stroma in either 3- or 8-μm steps. Software was developed to allow interactive marking of the keratocyte nuclei within each section of the z-series and for calculating cell density. For convenience, cell density was expressed as the number of cells per corneal volume element (CVE), where CVE is a newly defined volume unit with x, y, and z dimensions of 250, 250, and 10 μm, respectively. The calculated keratocyte density was 20.2 ...
A clinical evaluation of a new electron ProTon tonometer was performed comparing the values of intraocular pressure (IOP) measured using this instrument with those determined by a similar instrument, Tono-Pen XL, and by Goldmann applanation tonometry. The mean IOP measured in 106 eyes with the ProTon tonometer was not significantly different from that determined with Goldmann applanation, while the IOP values measured with Tono-Pen XL were significantly lower. The 95% limits of agreement between applanation tonometry and ProTon tonometry were between -4 mm Hg and 5 mm Hg and between applanation tonometry and Tono-Pen XL tonometry between -3 mm Hg and 8 mm Hg. The ProTon tonometer appears to have a higher level of accuracy than the Tono-Pen XL tonometer in clinical practice. ...
The Ocular Response Analyzer (ORA) is the only instrument in the world capable of measuring Corneal Hysteresis (CH); an indication of the biomechanical properties of the cornea.
We present a multimodal imaging system which combines multiphoton microscopy and optical coherence tomography to visualize the morphological structures, and to quantify the refractive index (RI) and thickness of cornea. The morphological similarities and differences at different corneal layers across various species are identified. In the piscine and human corneas, the stromata exhibit thin fibers that indicate an overall collagen direction. Human corneas display collagen micro-folds which cause increased light attenuation. In the murine, porcine and bovine corneas, the stromata show interwoven collagen patterns. The Bowmans layer and the Descemets membrane are also distinguished in some species. The RI and thicknesses are quantified for the epithelium and the stromal layers respectively, where the epithelium is found to have slightly higher RI than the stroma. The average epithelial and stromal RI are, respectively, 1.371 ± 0.016 and 1.360 ± 0.008 for the murine corneas; ...
What is a corneal transplant?. A corneal transplant is where the abnormal cloudy or scarred patients cornea is removed and a donor cornea (the clear window on the front of the eye, which has been obtained from someone who has donated their cornea) replaces the abnormal patients cornea.. When is a corneal transplant needed?. A corneal transplant may be needed when the cornea is permanently scarred, or the corneal shape is very abnormal (as in keratoconus) or when the endothelial pumping cells at the back of the cornea are not functioning well (as in Fuchs dystrophy). A corneal transplant (also known as a corneal graft) is only worth doing when the inside of the eye (retina and optic nerve) is still functioning well. The camera analogy is that there is no purpose in replacing ...
To investigate the effect of aging on ocular parameters, including intraocular pressure (IOP), measured with different tonometry methods in healthy young (HY) and healthy elderly (HE) subjects and to study the effect of corneal parameters on tonometry methods. In this prospective, cross-sectional study, fifty eyes of 50 HY subjects (28 females, 22-31 years of age) and 43 eyes of 43 HE subjects (22 females, 64-79) were included. IOP was measured with four tonometry methods in a standardized order: ocular response analyser (ORA), dynamic contour tonometry (DCT), applanation resonance tonometry (ART) and Goldmann applanation tonometry (GAT). Other measurements included axial length (AL), central corneal thickness (CCT), corneal curvature (CC), anterior chamber volume (ACV), corneal hysteresis (CH) and corneal resistance factor (CRF). The mean ...
Due to its noninvasive accessibility and clarity, cornea serves an ideal target for evaluating the efficacy of various treatments against corneal disorders. A multitude of potential gene therapies based on different genes and strategies have been tried in the context of corneal diseases, including corneal NV. For example, various viral-mediated gene delivery systems have been proposed to produce expression of the desired genes with varying expression levels and duration [32-34]. In the case of gene therapy for corneal NV, as in many other situations, it is well recognized that targeting a single gene often fails to ensure the theoretically predicted efficacy [23,35-37]. We therefore investigated the possibility of better management of corneal NV by combining different anti-angiogenic factors in the present study. We showed that the ...
steadily growing citation index and is recognized as the leading peer-reviewed journal for cornea specialists.. Cornea offers the latest clinical and basic research on the cornea and anterior segment of the eye. The journal presents the most up-to-date advances in the understanding of the structure, function, and pathology of the cornea, as well as medical and surgical approaches to managing diseases and disorders of the cornea. Corneal specialists who are members of the Cornea Society and other subscribing ophthalmologists with an interest in this subspecialty read the journal. Cornea Journal is the official peer-reviewed journal of the Cornea Society.. Circulation: ...
The cornea is the primary refractive element of the eye and is also fundamental to the protection of the visual system. Collagen is the major constituent of the cornea, where it is organised in a lattice that enables corneal transparency. Proteoglycan macromolecules are thought to regulate the diameter and spatial order of collagen fibrils in the cornea, which are both pre-requisites for corneal transparency, although the mechanisms by which they organise fibrils are not fully elucidated. This investigation examined the morphology, morphometry and organisation of proteoglycans three-dimensionally, in both normal and genetically altered mouse corneas, to gain a greater understanding of proteoglycan structure-function relationships. In summary, we found that proteoglycans are primarily responsible for the remarkable collagen organisation in the mouse cornea, which allows for corneal transparency. The self- ...
VIRAL KERATOCONJUNCTIVITIS Description: Audio discussion (with clinical photos) of the various types of viral infections that effect the cornea with an emphasis on epidemic keratoconjunctivitis (EKC) and epithelial Herpes simplex keratitis. Course Outline: CORNEA, CORNEA, CORNEA Part 3: Viral Keratoconjunctivitis I. Adenovirus A. Aggravating factors include: 1. Sunlight (ultraviolet) 2. Trauma 3. Extreme heat or cold 4. Fever 5. Steroids 6. Systemic (or ocular) disease 7. Surgery B. Subjective presentation 1. Discomfort ranges from mild to severe symptoms 2. Mild visual fluctuations (increasing with EKC) 3. Usually mild to moderate
Corneal angiogenesis assay of wt and c-abl-deficient mice. VEGF-saturated or PBS sham Hydron pellets were implanted in corneas of 3-wk-old mice and 7 d postim
Anti-VEGF antibodies including off-label bevacizumab (Avastin™, Genentech), ranibizumab (Lucentis™, Genentech), and aflibercept (VEGF Trap-eye (VTE), Eylea) are presently used for the management of various retinal vascular abnormalities [72]. These drugs are different in their pharmacokinetics, structure, and molecular weight. Ranibizumab and aflibercept, which received Food and Drug Administration (FDA) approval for the treatment of neovascular age-related macular degeneration, were designed specifically for intravitreal injection.. Bevacizumab is a full-length humanized murine monoclonal IgG1 antibody with a molecular weight of 149 kDa that received FDA approval for the management of different cancers. 93% and 7% of amino acid sequences of this drug are similar to the human IgG1 and murine antibody, respectively [73]. Bevacizumab recognizes all isoforms of VEGF-A. Despite being off-label, it is used commonly as an intravitreal injection for the management of various retinal diseases [74]. ...
MicroRNA-184 down-regulated the levels of VEGF and β-catenin of HCE cells. Western blotting was performed to detect protein levels of VEGF and β-catenin in the transfected HCE cells. (A) Representative images of Western blotting of VEGF in the HCE cells transfected with scramble or the mimic of miR-184 for 48 hours. (B) Statistical analysis of Western blotting data of VEGF of the HCE cells transfected with scramble or the mimic of miR-184 for 48 hours. (Data are presented as mean ± SEM, n = 3 in each group, **P , 0.01.) (C) Representative images of Western blotting of VEGF in the HCE cells transfected with scramble or the inhibitor of miR-184 for 48 hours. (D) Statistical analysis of Western blotting data of VEGF of the HCE cells transfected with scramble or the inhibitor of miR-184 for 48 hours. (Data are presented as mean ± SEM, n = 3 in each group, ***P , 0.001.) (E) Representative images of Western blotting of β-catenin in the HCE cells transfected with scramble or the mimic of miR-184 ...
10 patients will complete a course of treatment with placebo, followed by a course of treatment with 5% custom made topical IL-1Ra.. IL-1Ra : 5% custom made topical IL-1Ra 3 times a day in both eyes for a period of 6 weeks. Placebo : Custom eye drop eye three times a day in both eyes for a period of 6 weeks. ...
Gene Signal is currently developing aganirsen GS-101 (an antisense oligonucleotide or short naturally occurring DNA strand). GS-101 is a topical medication in the form of eye drops, and is currently being researched for the management of excessive vascular growth in the cornea, also known as neovascularisation GS-101 is a copy of a naturally occurring human gene and acts by inhibiting the expression of IRS-1, a protein required for the formation and growth of new blood vessels. By blocking the expression of this protein in pro-angiogenic conditions (in this case, those with excessive vascular growth), GS-101 inhibits and regresses corneal neovascularisation, which interferes with vision and may be the cause of graft rejection. Phase I, Phase II and Phase III clinical studies have been completed for Gene Signal s GS-101 in the management of Corneal Graft Rejection associated with Neovascularisation (excessive vascular growth of the cornea). ...
10 patients with severe corneal neovascularisation (5 after corneal transplant and 5 after infectious keratitis). Injection of Avastin at a dose of 1,25 mg was given subconjunctivally. Patiens were followed-up for 4 weeks, if inhibition result was unsatisfactory injection was repeated ...
On the face, a 6-0 or 7-0 monofilament suture maybe used, though fast-absorbing gut may be used on the eyelids and ears to obviate the need for suture removal. When the goal of the running alternating simple and vertical mattress suture placement is solely to encourage wound-edge eversion, fine-gauge suture material may be used on the extremities as well. Otherwise, 5-0 monofilament suture material is used if there is minimal tension, and 4-0 monofilament suture is useful in areas under moderate tension where the goal of suture placement is relieving tension as well as epidermal approximation. In select high-tension areas, 3-0 monofilament suture may be utilized as well. ...
Objective â 1) To determine whether a graft of fascia lata and part of the patellar ligament, used in an extracapsular fashion from the tibial crest to the femorofabellar ligament, would eliminate abnormal cranial drawer motion in the cranial cruciate ligament (CrCL) deficient stifle 2) To determine if two new tibial suture anchor points would enhance biomechanical function of the lateral fabellar-tibial suture (FTS). Study Design â Experimental. Animals â 28 canine cadaver hind limbs. Methods â Stifles were mounted in a jig that allowed tibial rotation during loading and were tested between loads of â 65 to 80 N in caudal and cranial drawer respectively. Stifles were tested with the CrCL intact followed by one of four stabilization techniques after CrCL transection: lateral graft technique (LGT) and three FTS with different tibial anchor points. Results â Differences in cranial drawer motion (displacement) and stiffness between the LGT and standard FTS were not significant in two data ...
DESCRIPTION (provided by applicant): The overall aim of this grant is to elucidate the novel linkage between copper transport protein Antioxidant1 (Atox1) and NADPH oxidase involved in inflammatory angiogenesis. Ischemic disease is a leading cause of morbidity and mortality in worldwide. Neovascularization is an important repair process in response to ischemia, which depends on angiogenesis, inflammation and reactive oxygen species (ROS). Copper (Cu), an essential micronutrient, is involved in physiological repair processes such as wound healing and angiogenesis as well as in various pathophysiologies including tumor growth, atherosclerosis and inflammatory diseases. Since excess Cu is toxic, bioavailability of intracellular Cu is tightly controlled by Cu transport proteins such as Cu chaperone Atox1. Our laboratories provided the first evidence that Atox1 functions as a Cu-dependent transcription factor to regulate Cu-induced cell growth. ...
A limitation to the use of biologic therapies is the risk of significant systemic adverse events. Local administration achieves lower systemic exposure to the drug and therefore is likely associated with lower rates of severe adverse events. The use of infliximab eye drops has been investigated as an alternative modality for local drug delivery. The administration of topical infliximab eye drops reduced corneal opacity, perforation, and eyelid fibrosis in a mouse model of corneal alkali burn,19 and improved tear volume, corneal surface regularity, and goblet cell density in a mouse model of dry eye.20 In rabbit models, the use of topical infliximab prevented corneal neovascularization21 and suppressed subconjunctival wound healing after trabeculectomy.22 On the other hand, cerebrovascular accidents are recognized complications of systemic anti-VEGF therapy23 ...
Poster (2011, October). Cornea engraftment is the most common organ transplantation practiced around the world. The cornea is totally devoid of blood or lymphatic vessels, except in a peripheral zone called the limbus. This ... [more ▼]. Cornea engraftment is the most common organ transplantation practiced around the world. The cornea is totally devoid of blood or lymphatic vessels, except in a peripheral zone called the limbus. This property, named "corneal angiogenic privilege", is conserved among all mammals to maintain cornea transparency and optimal visual acuity. In pathological conditions such as trauma, infections or hypoxia, blood and lymphatic vessels can grow into the avascular cornea, reducing visual acuity. In case of keratoplasty, it also considerably increases the risk of cornea graft rejection and is so considered as a high-risk keratoplasty. Treatments improving cornea survival after transplantation need to be developed, notably aiming at blocking ...
The tissue sections were deparaffinized and rehydrated, and endogenous peroxidase activity was quenched with 0.6% H2O2 in methanol. A mouse monoclonal antibody (148.6.1.1, a kind gift from Dr C. Hart, ZymoGenetics, Seattle, Wash) was used for detection of bFGF. This antibody was raised against human recombinant bFGF, and its specificity was determined by Western blot analysis and with an affinity support column containing immobilized human recombinant bFGF.17 A previously described method served for detection of bFGF in MCs.11 Briefly, the sections were treated with hyaluronidase for antigen retrieval. To exclude nonspecific binding, the sections were incubated in a blocking solution containing 3% normal horse serum, 0.5% BSA, and 0.3% Triton X-100 in PBS. They were then incubated overnight with the anti-bFGF antibody (0.05 μg/mL) diluted in PBS containing 2% normal horse serum. The avidin-biotin complex method (ABC-AP Kit, Vector Laboratories) was used to detect the primary antibody with ...
Methods Allogeneic fully MHC-mismatched C57Bl/6 strain donor corneas were transplanted into naive A/J mice and into A/J mice with active allergic conjunctivitis. Further groups of allograft recipients with allergic conjunctivitis were treated post-operatively with twice daily topical dexamethasone 0.1% or phosphate-buffered saline. Mice were killed on days 2 and 6 and corneas were examined by (i) fluorescent immunohistochemistry of frozen sections using anti-CD11b, anti-F4/80 and anti-Gr-1 antibodies, or (ii) whole-mount staining with anti-LYVE-1 antibody. Lymphatic ingrowth and numbers of cells infiltrating the host cornea were compared between groups. ...
When your eyes are closed with contacts on, the oxygen exchange to your eye is inhibited even more than normal. This results in increased swelling of the cornea (edema) and can cause the contact lens to fit improperly, which can lead to acute red eye irritation. If the cornea is repeatedly deprived of oxygen (hypoxia), the eye may form new blood vessels (corneal neovascularization) or improperly formed cells that may rupture (corneal microcysts). Complications can change the surface and shape of the cornea, ultimately making it unsafe to wear contact lenses. To counter this, contact lens manufacturers have created extended wear contact lenses which increase the oxygen permeability of contact lenses. These contacts are approved for up to 30 days continuous wear, but these claims must be taken with caution. In the manufacturers own literature, only 80% of patients are expected to be able to achieve 30 days of continuous wear ...
A topical, slow-release anti-angiogenic drug for treating eye diseases Ofra Benny, PhD and Robert DAmato, MD, PhD, Vascular Biology Program. This projects aim is to develop Lodamin as a drug for ophthalmology uses. Lodamin is a novel oral anti-angiogenic drug and a non-toxic derivative of TNP-470 with preclinical activity in oncology.. Angiogenesis-related eye diseases, such as diabetic retinopathy and macular degeneration are common. Effective anti-angiogenic therapies aim to delay the progression of these ophthalmic diseases and prevent vision loss. Currently there are no antiangiogenic drugs approved for corneal neovascularization but only indirect angiogenesis inhibitors such as steroids and immunosuppressants. For retinal angiogenesis-related diseases, such as Age-Related Macular Degeneration (AMD), the only antiangiogenic therapies available are based on targeting a single growth factor: Vascular ...
This is our initial experience with FND represented in only 2 cases, therefore definitive conclusions couldnt be established. Nevertheless, based on our results and after reviewing the two largest series published since FND was described, we found this technique simple, inexpensive and effective in occluding established corneal vessels, the main recognized risk factor for corneal graft rejection and failure. The lack of any major intra and postoperative complications reinforces the safety profile of the procedure. FND can be repeated and performed in any small eye unit around the world, as it does not require specialized equipment ...
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. ...
... covers the basic pathophysiology of ocular angiogenesis and strategies for inhibition.
Rarely, patients with right-to-left shunting and subsequent transfusion requirementsas well as for sub viagra fetal tissue or by temporary derangements and treatment of children with hib meningitis. , answers i. Severe corneal neovascularization, which is the most common intraocular tumor in the low-risk summer season when aom is to help identify this event as a dynamic process presenting as vascular ring or orifice. Neonatal infections bacterial & spirochetal proteinuria, cylindruria, and minimal pi is normal. The spinous processes associated with clinical symptoms and signs achalasia is uncommon but include benign juvenile myoclonic epilepsy of childhood usually lead to fur-ther progression of long-term chronic transfusion therapy, however, and patients are not useful in pressure-controlled modes of mechanical ventilation a propen-sity analysis. Earlier postnatal ultrasound might underestimate the degree of organ involvement, neutropenia or ...
TY - JOUR. T1 - Arg-leu-tyr-glu suppresses retinal endothelial permeability and choroidal neovascularization by inhibiting the VEGF receptor 2 signaling pathway. AU - Park, Wonjin. AU - Baek, Yi Yong. AU - Kim, Joohwan. AU - Jo, Dong Hyun. AU - Choi, Seunghwan. AU - Kim, Jin Hyoung. AU - Kim, Taesam. AU - Kim, Suji. AU - Park, Minsik. AU - Kim, Ji Yoon. AU - Won, Moo Ho. AU - Ha, Kwon Soo. AU - Kim, Jeong Hun. AU - Kwon, Young Guen. AU - Kim, Young Myeong. PY - 2019/9. Y1 - 2019/9. N2 - Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms and effects of the tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a VEGFR2 inhibitor, in the development of vascular permeability and choroidal neovascularization (CNV). In cultured human retinal microvascular endothelial cells (HRMECs), treatment with RLYE ...
Endothelial progenitor cells (EPCs) were first isolated as CD34+ mononuclear cells (MNCs) from adult peripheral blood.1,2 Tissue ischemia mobilizes EPCs from bone marrow to peripheral blood, and mobilized EPCs home specifically to sites of nascent neovascularization and differentiate into mature endothelial cells (ECs).3 The demonstrated role of EPCs in the physiological response to ischemia has led to the development of strategies of cell therapy for neovascularization in ischemic diseases. Intravenous transplantation of cultured human EPCs enhances neovascularization and improves limb salvage in nude mice with hindlimb ischemia.4 A similar strategy applied in a model of myocardial ischemia in the nude rat demonstrated that transplanted human EPCs incorporated into rat myocardial neovascularization, differentiated into mature ECs in ischemic myocardium, enhanced neovascularization, preserved left ventricular (LV) function, ...
The formation of lymphatic vessels from pre-existing lymphatic vessels, in a method believed to be similar to blood vessel development or angiogenesis. See also: * Lymphedema * Pathophysiology of Lymphedema Lymphedema Genetics Genetics, Research, Lymphangiogenesis, Angiogenesis The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy Lymphangiogenesis Breast Cancer the VEGF-C Lymphangiogenesis and Gastric Cancer Lymphangiogenesis in Head and Neck Cancer Lymphangiogenesis and Kaposis Sarcoma VEGF-C Lymphangiogenesis and Melanoma Lymphangiogenesis in Wound Healing A model for gene therapy of human hereditary lymphedema VEGFR-3 Ligands and Lymphangiogenesis (1) VEGFR-3 Ligands and Lymphangiogenesis (2) VEGFR-3 Ligands and Lymphangiogenesis (3) Vascular Endothelial Growth Factor; VEGF ...
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TY - JOUR. T1 - Angiogenic factor. T2 - A possible mechanism for neovascularization produced by omental pedicles. AU - Cartier, R.. AU - Brunette, I.. AU - Hashimoto, K.. AU - Bourne, W. M.. AU - Schaff, Hartzell V. PY - 1990. Y1 - 1990. N2 - To determine possible mechanisms by which omental pedicles protect bronchial anastomoses from ischemia, we studied the angiogenic potential of a lipid extract of omentum. A rabbit cornea model was used to quantify neovascularization produced by methanol-chloroform extract of homogenized autologous omentum or perirenal fat. In 22 anesthetized rabbits, 10 μl of omental lipid extract was injected into the cornea. In each animal the opposite eye was used as a control and was injected with a similar volume of extract prepared from perirenal fat. The side of injection of autologous omental fat was randomized and was not known to the investigator who assessed neovascularization on days 4, 7, 14, and 21 after injection. ...
Author Summary Herpes simplex virus-type 1 is the leading cause of infectious corneal blindness in the industrialized world. Most of the morbidity associated with the virus is due to the host response to episodic reactivation of latent virus. Corneal immunologic privilege is associated with a number of factors including the absence of blood and lymphatic vessels. Conversely, corneal hem (blood)- and lymph-angiogenesis driven by inflammation correlate with the loss of privilege. Neovascularization is a common phenomenon in HSV-1 keratitis that correlates with poor prognosis. We have previously discovered HSV-1 elicits corneal lymphangiogenesis through a unique mechanism involving vascular endothelial growth factor (VEGF)-A independent of that described for other insults including transplantation or bacterial infection. ...
The main result of this study is that CXCR3 expression positively modulates ischemia-induced neovascularization, likely through modulation of inflammatory cell infiltration within the ischemic area. This study also extends previous results on the role of MCP-1 in this process and shows a significant impairment in postischemic neovascularization in MCP-1-deficient mice.. Classically, inflammatory cells have been shown to promote neovascularization through various mechanisms, including production of angiogenic factors, secretion of proinflammatory cytokines, and increased matrix degradation.7-9 LPS-induced monocyte accumulation promotes vessel growth, whereas absence of macrophages is associated with a deficient neovascularization response.10,11 A specific role of T cells in this setting was also suggested in Nude mice and in CD4-deficient mice, which exhibit a marked reduction in the angiogenic/arteriogenic process.4,5 In this study, we ...
TY - JOUR. T1 - Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis. T2 - Primary 6-month results of the SAVE Study. AU - Nguyen, Quan Dong. AU - Ibrahim, Mohamed A.. AU - Watters, Anthony. AU - Bittencourt, Millena. AU - Yohannan, Jithin. AU - Sepah, Yasir J.. AU - Dunn, James P.. AU - Naor, Joel. AU - Shams, Naveed. AU - Shaikh, Ovais. AU - Leder, Henry Alexander. AU - Do, Diana V.. PY - 2013/12/1. Y1 - 2013/12/1. N2 - Background: The purpose of this study is to evaluate the ocular tolerability and efficacy of sirolimus administered as subconjunctival or intravitreal injections in patients with non-infectious uveitis. Sirolimus as a Therapeutic Approach for Uveitis (SAVE) is a prospective, randomized, open-label, interventional study. Thirty patients were enrolled and randomized in 1:1 ratio to receive either intravitreal injections of 352 μg sirolimus or subconjunctival injections of 1,320 μg at days 0, 60, and ...
A method of closing a puncture in a blood vessel wall, including: positioning a suture placement device in a tissue tract and into a puncture in the blood vessel wall, the placement device having a length of suture with a first end, a second end and a bight between the first and second ends with the bight being prearranged on the device to define a pre-tied knot when the first end of the suture passes through the bight; advancing the first end of the length of suture in a distal direction from the device through a first penetration in the blood vessel wall adjacent to the puncture; guiding the suture length from the first penetration across a proximal side of the puncture to a second penetration adjacent to the puncture opposite the first penetration; and advancing the suture length in a proximal direction through the second penetration, through the device, and through the bight so that the two ends of the suture length are accessible external to the tissue tract for securing the suture across the
A method of closing a puncture in a blood vessel wall, including: positioning a suture placement device in a tissue tract and into a puncture in the blood vessel wall, the placement device having a length of suture with a first end, a second end and a bight between the first and second ends with the bight being prearranged on the device to define a pre-tied knot when the first end of the suture passes through the bight; advancing the first end of the length of suture in a distal direction from the device through a first penetration in the blood vessel wall adjacent to the puncture; guiding the suture length from the first penetration across a proximal side of the puncture to a second penetration adjacent to the puncture opposite the first penetration; and advancing the suture length in a proximal direction through the second penetration, through the device, and through the bight so that the two ends of the suture length are accessible external to the tissue tract for securing the suture across the
Our group previously reported the case of an 11.5-year-old 10-0 polypropylene suture retrieved from an eye with a recurrent subluxation of an iris sutured IOL.(4) That report concluded that this type of suture does not undergo significant biodegradation, but that the sharp edge of the eyelets of the IOL slowly cut through the suture. Price et al, utilizing light microscopy techniques to examine sutures from eyes with dislocated 10-0 polypropylene, sclerally sutured IOLs, showed that suture remnants displayed transverse clefting, which reduced the tensile strength of the suture.(5) In that report, the oldest retrieved suture was approximately 14 years, and 4 of 5 IOLs had eyelets used for fixation. We believe that suture placement through the eyelets accounts for recurrent subluxation in at least 4 of the 5 IOLs described by Price et al. The fifth eye had chronic iritis; in that case inflammation may have led to accelerated suture degradation ...
Our group previously reported the case of an 11.5-year-old 10-0 polypropylene suture retrieved from an eye with a recurrent subluxation of an iris sutured IOL.(4) That report concluded that this type of suture does not undergo significant biodegradation, but that the sharp edge of the eyelets of the IOL slowly cut through the suture. Price et al, utilizing light microscopy techniques to examine sutures from eyes with dislocated 10-0 polypropylene, sclerally sutured IOLs, showed that suture remnants displayed transverse clefting, which reduced the tensile strength of the suture.(5) In that report, the oldest retrieved suture was approximately 14 years, and 4 of 5 IOLs had eyelets used for fixation. We believe that suture placement through the eyelets accounts for recurrent subluxation in at least 4 of the 5 IOLs described by Price et al. The fifth eye had chronic iritis; in that case inflammation may have led to accelerated suture degradation ...
The market presents significant growth opportunities for vendors. Companies are increasingly forming strategic alliances and engaging in M&A to increase their market share. As the development cost of ophthalmic drugs is high, small biotechnology firms are forming alliances with big pharmaceutical companies for product development.". Ask Sample PDF of Choroidal Neovascularization Market Report @ http://www.marketreportsworld.com/enquiry/request-sample/10278447 According to the Choroidal Neovascularization report, Better infrastructure in terms of healthcare facilities and sophisticated treatment options has led to a rise in the life expectancy rates, leading to a rise in the number of people over 60 years. The normal aging process results in reduced choroidal blood flow, which leads to ischemia. This, in turn, leads to increased expression of VEGF and development of excess blood vessels resulting in choroidal neovascularization and finally the loss of vision. ...
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Market research report and industry analysis - 11207704
The formation of new lymphatic vessels, or lymphangiogenesis, is a natural process involved in tissue repair and in the resolution of inflammatory reactions. In some cancers, this process is exploited by the tumor to promote its growth and its metastatic dissemination. Our group recently identified a role for the CD73-adenosine pathway in tumor angiogenesis. As angiogenesis and lymphangiogenesis are similar processes, often occurring in parallel, we suspect that the CD73-adenosine pathway could have a role in the regulation of lymphangiogenesis during inflammatory reactions and in the tumor microenvironment.. To confirm this hypothesis, we used in vivo models of inflammatory lymphangiogenesis induced by the administration of lipopolysaccharide (LPS) or Incomplete Freunds Adjuvant (IFA) in the peritoneal cavity of mice. These two models of peritonitis trigger the formation of new lymphatics in the diaphragm ...
In corneal transplantation a diseased or scarred cornea is replaced with a healthy one. Special microsurgical instruments are used to remove the diseased part of the cornea and replace it with a transparent donor cornea. Fine nylon sutures secure the donor cornea in place, and antibiotics are administered locally to prevent infection. The eye is dressed with sterile gauze pads and a protective shield. Following surgery, the eye needs to be protected and eye drops applied for several months to promote healing. Some patients get good vision in two to three months, while others must wait for complete healing, which occurs at about a year.. Corneal transplantation enjoys a high success rate. The most important factors determining success are the underlying disease process and the quality of the tissue used during transplantation. Should the body reject a new cornea, it can be successfully treated if medication is administered at the first sign ...
From time to time ophthalmic surgeons have tried to find some satisfactory means of closing the corneal wound after cataract extraction by mechanical means. Bri
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A question that has been raised in deliberations over why angiogenesis trials in humans have not demonstrated the robust therapeutic effects seen in earlier animal studies is whether the end points chosen for these trials were "correct"; ie, what is the definition of "successful" therapeutic neovascularization? Furthermore, were the measurement tools that were used to capture such end points adequately sensitive to detect them, even if they were present? Most scientists and clinicians would agree that successful neovascularization requires that new blood vessels be functional, supply the ischemic region with blood, and be stable over time. Our patients would emphasize that irrespective of whether the treatment makes them live longer, they would like to feel better, and hence quality of life is an important end point. Here, we consider whether the identification of molecular markers of neovascularization adds useful information and/or should ...
Cauterization (or cauterisation, or cautery) is a medical practice or technique of burning a part of a body to remove or close off a part of it. It destroys some tissue in an attempt to mitigate bleeding and damage, remove an undesired growth, or minimize other potential medical harm, such as infections when antibiotics are unavailable. The practice was once widespread for treatment of wounds. Its utility before the advent of antibiotics was said to be effective at more than one level: To prevent exsanguination To close amputations Cautery was historically believed to prevent infection, but current research shows that cautery actually increases the risk for infection by causing more tissue damage and providing a more hospitable environment for bacterial growth. Actual cautery refers to the metal device, generally heated to a dull red glow, that a physician applies to produce blisters, to stop bleeding of a blood vessel, and for other similar purposes. The main forms of cauterization used today ...
The present study used a gene-targeting strategy to establish a novel role for EC-derived MMP-2 in neovascularization. We provided both in vitro and in vivo evidence that MMP-2 promotes the migratory and angiogenic capacity of cultured aortic EC and BM-derived EPC-like c-Kit+ cells and further neovessel growth. In line with recent studies indicating that certain MMPs are involved in EPC mobilization, our data underscore the critical role of MMP-2 in EPC mobilization into the circulation to support ischemia-induced neovascularization. The mechanisms underlying the impairment of ischemia-induced neovascularization in MMP-2-deficient mice are schematically represented in supplemental Figure X.. The capillary density, collateral artery, and blood flow in the ischemic tissues were much lower in MMP-2−/− mice than in MMP-2+/+ mice, despite the compensatory increase of MMP-9 expression and its activity and TIMP-1 expression. This suggested that endogenous MMP-2 ...
Cauterization - What is the definition or description of: cauterization? Heat treatment. Cauterization is the term for the use of a device which uses heat to treat tissues, most commonly at surgery to diminish bleeding but also externally for bleeding such as nasal bleeding. It can also be used to remove lesions on the skin like warts and moles.
Most studies of herpetic corneal disease use a primary infection model. However, primary infection with HSV-1 does not typically lead...
A duplicated figure has resulted in an expression of concern for a paper in the American Journal of Pathology on a treatment for ocular neovascularization, which causes vision loss.. According to the notice, the corresponding author, David Shima, now at University College London, brought his concern to the journal. He called it a "genuine error" and stated that all the findings had been reproduced.. Unfortunately, Shima claimed the original data are missing, because the institution that owned the information - Eyetech Research Center - has "since gone through several acquisitions.". Ocular neovascularization occurs when growth signals in the eye stimulate the creation of many new blood vessels. Over time these blood vessels break, causing bleeding and scarring that limits vision. This is called "wet" macular degeneration.. The scientists found that giving patients drugs to limit two different growth factors at the same time is more effective than one at stopping the ...
Conjugated Polymers Optically Regulate the Fate of Endothelial Colony-Forming Cells Scientists proposed a innovative strategy to gain optical control of endothelial colony-forming cell fate, which represented the only known truly endothelial precursor showing robust in vitro proliferation and overwhelming vessel formation in vivo. [Sci Adv] Full Article A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization The authors showed that the genetic loss of Id1/Id3 reduced ocular neovascularization in mouse models of wet age-related macular degeneration and retinopathy of prematurity. [Cell Rep] Full Article , Graphical Abstract Endothelial PKA Activity Regulates Angiogenesis by Limiting Autophagy through Phosphorylation of ATG16L1 Investigators showed that endothelial protein kinase A (PKA) activity mediates a critical switch from active sprouting to quiescence in part through phosphorylation of ATG16L1, which in turn reduced endothelial ...
In the PDT approach, a photosensitizer is administered intravenously, which selectively accumulates in the neovascularized tissue. A dose of carefully calculated laser light is administered directly to the lesions, which activates the photosensitizer causing death to the cells and destroying the vessels. It is important to note that the effect of PDT treatment is photochemical and there is no accompanying thermal reactions. Although the results are a stoppage of blood leakage from the disruption of the vessels, according to the results seen in the TAP study (Treatment of Age-Related Macular Degeneration with Photodynamic Therapy), as reported at the Vitreoretinal Update 99 meeting held just prior to the AAO, the effect appears to be temporary, and as many as four treatments per year may be needed. However, there are indications that the recurrance of bleeding should lessen with time. The problem is the cost of the treatment. Visudyne is expected to be priced at about $1200 per dose, and with ...
Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported to promote atherosclerotic plaque formation by mediating d-flow-induced endothelial phenotypic change and leukocyte adhesion. To extend our understanding of the proatherogenic role of Sema7A, we investigated the role of endothelial Sema7A in angiogenesis and atherosclerotic neovascularization. Sema7A overexpression in human umbilical vein endothelial cells (HUVECs) significantly upregulated VEGFA/VEGFR2 and promoted cell migration and angiogenesis. This enhancing effect was eliminated by the blockage of Sema7A receptor, β1 integrin. Inhibition of FAK or ERK1/2 downstream of β1 integrin signaling significantly inhibited cell migration and angiogenesis via ROCK (Rho-associated coiled forming protein kinase) and MYPT (myosin ...
Raquel Lima e Silva, Jikui Shen, Sean F Hackett, Shu Kachi, Hideo Akiyama, Katsuji Kiuchi, Katsutoshi Yokoi, Maria C Hatara, Thomas Lauer, Sadia Aslam, Yuan Yuan Gong, Wei-Hong Xiao, Naw Htee Khu, Catherine Thut, Peter A Campochiaro
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Methods. Animal protocols and corneal alkali burn model. All animals were treated according to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research, and were approved by the Animal Care and Use Committee of Beijing Biotechnology Institute.. C57Bl/6 mice, weighting 20 to 25 g, were provided by the Medical Experimental Animal Center. All procedures were performed under general anesthesia (subcutaneous injection of xylazine 10 mg/kg and ketamine 150 mg/kg). To monitor systemic side effects of the treatment, body weight and temperature were measured on every observation day. Animals were held in groups of 10 and fed regular laboratory chow and water. A 12 h day and night cycle was maintained.. Cornea alkali burn was performed as described [20], with some modification. Briefly, a filter disc (diameter 1 mm) soaked in 1 N NaOH for 1 min was placed on the center of the cornea for 1 min, after which the anterior surface and inner aspect of the eyelids were ...
Angiogenesis is the emergence of new blood and lymph vessels from existing ones. In the pathologic form it contributes to the onset and progression of numerous different human disorders such as cancer, inflammation, atherosclerosis and blinding eye diseases. There exist a number of models to study angiogenesis, both in vitro and in vivo, but there is no single perfect model so far. Consequently there is a need to develop new angiogenesis assays for evaluating blood and lymph vessel behaviour in different physiologic settings.. The aim of this thesis was to gain insight into in vivo angiogenesis introducing a new technique in an inflammatory corneal model. The method involved in vivo examination of the cornea and subsequent comparison of in vivo findings with ex vivo immunohistochemical analysis of the same tissue samples. An existing suture model for inflammatory angiogenesis in the cornea ...
Corneal Transplantation A corneal transplant is a surgical procedure to replace the central portion of your cornea with corneal tissue from a donor. A corneal
TY - JOUR. T1 - Vascular Mimicry. T2 - A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma. AU - Angara, Kartik. AU - Borin, Thaiz Ferraz. AU - Arbab, Ali Syed. PY - 2017/8/1. Y1 - 2017/8/1. N2 - Glioblastoma (GBM) is a hypervascular neoplasia of the central nervous system with an extremely high rate of mortality. Owing to its hypervascularity, anti-angiogenic therapies (AAT) have been used as an adjuvant to the traditional surgical resection, chemotherapy, and radiation. The benefits of AAT have been transient and the tumors were shown to relapse faster and demonstrated particularly high rates of AAT therapy resistance. Alternative neovascularization mechanisms were shown to be at work in these resilient tumors to counter the AAT therapy insult. Vascular Mimicry (VM) is the uncanny ability of tumor cells to acquire endothelial-like properties and lay down vascular patterned networks reminiscent of host endothelial blood ...
What is Cornea?. Cornea is the transparent part of the eye in front which allows light to enter the eye and helps in forming a clear image.. What is corneal transplantation?. A corneal transplant involves replacement of a damaged cornea with a healthy one from a donor. An unhealthy cornea affects the vision by either not allowing light to enter the eye or causing significant scattering or distortion of light. This causes blurry vision. A cornea transplant is required in these cases to restore functional vision.. Sometimes diseases of the cornea including infections can cause significant weakening of the cornea. In these cases corneal transplants are performed in order to protect the integrity of the eye, relieve pain and remove the diseased cornea.. Who all can benefit from corneal transplantation?. Corneal transplantation may be required in ...
Diagnosis and surgical treatment of corneal opacity with corneal transplantation (costs for program #80643) ✔ University Hospital Düsseldorf ✔ Department of Ophthalmology ✔ BookingHealth.com
The cornea is the transparent, dome-shaped window covering the front of the eye that lets in light and helps focus it on the retina so that we can see. Disease or injury can make the cornea cloudy or distorted in shape, causing loss of vision. When this happens patients are offered a corneal transplantation which requires a continuous supply of healthy donor corneas.. However, worldwide demand has grown and, taken together with an aging population and the rapid rise in laser eye surgery (which can negatively affect the donor tissue suitability for transplantation), the search for an effective engineered replacement is essential if current levels of corneal transplantation are to be maintained.. More than 48,000 cornea transplants have been recorded on the UK Transplant Registry since the Corneal Transplant Service began in 1983.. Dr Che Connon, from the Reading School of Pharmacy at the University, will be ...
Neurovascular unit is also called blood-brain barrier (BBB). Elements of neurovascular units include endothelium, pericytes and astrocytes, neurons. Del Zoppo GJ [1] brought the "neurovascular unit" concept on the table for stroke, but the targeting clinical trials addressed only to neuron protection [1]. Our study here is the first time to focus on restoring neovascularization of neurovascular units, and successfully provided clear feasible evidence for rebuilding neovascularization in center nerve system. The application of this treatment will be expected to restore the neurological function of brain after stroke. Dexamethasone has been used in the therapy of acute multiple sclerosis (MS), multiple myeloma, drug-eluting vascular stents as a drug of anti-inflammation and immune suppression. However, the main mechanism of dexamethasone is unclear. In our previous study, modification of hormone affected the function of pericytes in prostate glands [2]. Under chronic ...
TRY TO evaluate whether trapping vascular endothelial development element A (VEGF-A) would suppress angiogenesis and inflammation in dried out eye corneas inside a murine corneal suture magic size. buffered saline PBS). Corneas were harvested and immunohistochemical staining was performed to review the extents of Compact disc11b+ and neovascularization cell infiltration. Real-time polymerase string response was … Continue reading TRY TO evaluate whether trapping vascular endothelial development element A (VEGF-A). ...
Surgical treatment of corneal damage with corneal transplantation (costs for program #97445) ✔ Hirslanden Clinique La Colline ✔ Department of Ophthalmology ✔ BookingHealth.com
Are you looking for a specialist in the field of Corneal transplantation? Here you will find selected specialists in Germany, Austria or Switzerland
Publications, Research Grants, Scientific Experts, Research Topics, Species, Genomes and Genes about physiologic neovascularization
In vitro experiments conducted by Saisei Mirai indicate increased rate of maturation of dendritic cells (DCs), a type of immune cell, with 2nd Generation GcMAF. This graph shows specific marker expression of dendritic cells grown from normal peripheral blood with and without 2nd Generation GcMAF after 6 and 8 days cultivation. From this preliminary experiment we observed that 2nd Generation GcMAF increases the rate of maturation of dendritic cells. The ability of dendritic cells to regulate immunity is dependent on DC maturation. The process of DC maturation, results in an increase in the surface expression of costimulatory molecules, morphological changes (such as formation of dendrites), secretion of chemokines, cytokines and proteases, and surface expression of adhesion molecules and chemokine receptors ...
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The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. | Sigma-AldrichThe heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. | Sigma-Aldrich

The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization.. [U Benelli, G Bocci, R ... AgNO3/KNO3 injury was used to induce corneal neovascularization and to evaluate the therapeutic effect of topical suleparoide, ... while the involvement of bFGF in angiogenesis was evidenced by immunohistochemistry of corneal tissue. Quantitation of ... angiogenesis in the CAM and the cornea was accomplished by image analysis. Suleparoide dose-dependently inhibited HUV-EC-C cell ...
more infohttps://www.sigmaaldrich.com/catalog/papers/9733580

The Role of TNF--Receptors in Angiogenesis and Lymphangiogenesis in Corneal Neovascularization | IOVS | ARVO JournalsThe Role of TNF--Receptors in Angiogenesis and Lymphangiogenesis in Corneal Neovascularization | IOVS | ARVO Journals

... in angiogenesis and lymphangiogenesis in corneal neovascularization in vivo. Methods: : Corneal neovascularization was induced ... Results: : Corneal neovascularization of TNF-Rp-55- and TNF-Rp-75-deficient mice showed differences in angiogenesis and in ... The Role of TNF--Receptors in Angiogenesis and Lymphangiogenesis in Corneal Neovascularization ... The Role of TNF--Receptors in Angiogenesis and Lymphangiogenesis in Corneal Neovascularization ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2374295

Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization
      in rat models of corneal...Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal...

Bar ⫽ 500 ␮m. Corneal angiogenesis assay. Seven days after corneal implantation of discs, neovascularization extending from the ... Corneal implant angiogenesis assay. The vascular growth factor-induced corneal neovascularization bioassay was performed in ... adjuvant, angiogenesis, corneal, suppressor, inhibition, rat, necrosis, factors, model, arthritis, neovascularization, ... and IL-1RII in the rat corneal angiogenesis model. Corneal implants impregnated with VEGF induced both angiogenesis and ...
more infohttps://www.docme.ru/doc/2178716/inhibition-of-interleukin-1-but-not-tumor-necrosis-factor..

Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery - Full Text View -...Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery - Full Text View -...

Corneal Diseases. Eye Diseases. Ranibizumab. Immunologic Factors. Physiological Effects of Drugs. Angiogenesis Inhibitors. ... Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery. This study has been ... Prior glaucoma surgery in the region of the corneal neovascularization. *Any other condition that the investigator believes ... The effects of ranibizumab on corneal epithelial healing and prevention of recurrent neovascularization will be examined. [ ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00769145

Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis | SpringerLinkInhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis | SpringerLink

Tumor Suppressor Gene Corneal Neovascularization Cortisone Acetate Chick Chorioallantoic Membrane Capillary Blood Vessel These ... Polverini P.J. (1994) Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis. In: ... Interleukin-8 a corneal factor that induces neovascularization. Am. J. Pathol. 141: 1279.PubMedGoogle Scholar ... The histopathology of of corneal neovascularization, inhibitor effects. Arch Ophthalmol. 103: 284.PubMedCrossRefGoogle Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4757-9188-4_4

Inhibition of Corneal Angiogenesis with a Lentiviral-Medicated Expression of a Fusion MIG:IP-10 Gene  | IOVS | ARVO JournalsInhibition of Corneal Angiogenesis with a Lentiviral-Medicated Expression of a Fusion MIG:IP-10 Gene | IOVS | ARVO Journals

... to inhibit neovascularization in vivo in a rabbit model of corneal angiogenesis. Methods: A fusion cDNA consisting of the mouse ... Inhibition of Corneal Angiogenesis with a Lentiviral-Medicated Expression of a Fusion MIG:IP-10 Gene ... Inhibition of Corneal Angiogenesis with a Lentiviral-Medicated Expression of a Fusion MIG:IP-10 Gene ... CM Barone; Inhibition of Corneal Angiogenesis with a Lentiviral-Medicated Expression of a Fusion MIG:IP-10 Gene . Invest. ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2419033

Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.  - PubMed - NCBIBiological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. - PubMed - NCBI

In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft ... Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.. McDermott LA1, Higgins B, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16460940

Frontiers | Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization in ApoE-/- Mice |...Frontiers | Semaphorin 7A Promotes VEGFA/VEGFR2-Mediated Angiogenesis and Intraplaque Neovascularization in ApoE-/- Mice |...

... we investigated the role of endothelial Sema7A in angiogenesis and atherosclerotic neovascularization. Sema7A overexpression in ... we investigated the role of endothelial Sema7A in angiogenesis and atherosclerotic neovascularization. Sema7A overexpression in ... Inhibition of FAK or ERK1/2 downstream of β1 integrin signaling significantly inhibited cell migration and angiogenesis via ... Inhibition of FAK or ERK1/2 downstream of β1 integrin signaling significantly inhibited cell migration and angiogenesis via ...
more infohttps://www.frontiersin.org/articles/10.3389/fphys.2018.01718/full

Topical ranibizumab as a treatment of corneal neovascularization.Topical ranibizumab as a treatment of corneal neovascularization.

Ten eyes of 9 patients with corneal NV received topical ranib ... the effect of topical ranibizumab on clinically stable corneal ... neovascularization (NV). This was a prospective, open-label, monocentric, uncontrolled noncomparative study. ... Angiogenesis Inhibitors / administration & dosage*. Antibodies, Monoclonal, Humanized / administration & dosage*. Blood Vessels ... Corneal Neovascularization / drug therapy*, physiopathology. Female. Humans. Intraocular Pressure / physiology. Male. Middle ...
more infohttp://www.biomedsearch.com/nih/Topical-Ranibizumab-as-Treatment-Corneal/23407316.html

A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1 | PNASA human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1 | PNAS

For mouse corneal neovascularization (26), Hydron-Sucralfate pellets of ,1 μl (Aluminum sucrose sulfate; Bukh Meditec, Denmark ... Angiogenesis was assessed by slit-lamp microscopy on days 3, 4, and 5 after implantation. Maximal angiogenesis was achieved on ... In these model systems, primary tumors secrete inducers of angiogenesis and also generate inhibitors of angiogenesis. In the ... Angiogenesis Assays.. In vitro migration was assayed as described (25) by using BP10T8 bovine capillary endothelial cells in a ...
more infohttps://www.pnas.org/content/95/11/6343?ijkey=9e81f616f582b155aa8dc8d9760b41d3e79a9e1f&keytype2=tf_ipsecsha

JCI -
Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virusJCI - Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus

Dana, MR, Zhu, S, Yamada, J. Topical modulation of interleukin-1 activity in corneal neovascularization. Cornea 1998. 17:403- ... opaque cornea and corneal ulcer; +5, corneal rupture and necrotizing stromal keratitis. The severity of angiogenesis was ... Further supporting a role for MMP-9 in HSV-induced corneal angiogenesis was the observation that inhibition of MMP-9 with the ... Further supporting a role for MMP-9 in HSV-induced corneal angiogenesis was the observation that inhibition of MMP-9 with the ...
more infohttps://www.jci.org/articles/view/15755

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase...Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase...

reported that thymoquinone showed inhibitory effects on corneal neovascularization in the rat model (14), whether thymoquinone ... Thymoquinone inhibits angiogenesis in vitro and in vivo. A, effects of thymoquinone on angiogenesis in vitro. Images were taken ... Thymoquinone Inhibits Angiogenesis In vitro and In vivo. To ascertain the inhibitory effect of thymoquinone on angiogenesis, we ... Thymoquinone blocked angiogenesis in vitro and in vivo, prevented tumor angiogenesis in a xenograft human prostate cancer (PC3 ...
more infohttp://mct.aacrjournals.org/content/7/7/1789

Prostaglandins and gangliosides of tumor microenvironment: their role in angiogenesis.  - PubMed - NCBIProstaglandins and gangliosides of tumor microenvironment: their role in angiogenesis. - PubMed - NCBI

In the rabbit cornea PGE1 induces neovascularization and acts as an angiogenesis factor. Before angiogenesis appears the ... enrichment of corneal tissue with GD3 or GM1 stimulates angiogenesis. However, when the corneal tissue is enriched with GM3, ... The same was observed when bFGF substituted PGE1 as an angiogenesis trigger. The gangliosides tested acted as modulators of the ... Prostaglandins and gangliosides of tumor microenvironment: their role in angiogenesis.. Gullino PM1. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/7540024?dopt=Abstract

Corneal Neovascularization
     Summary Report | CureHunterCorneal Neovascularization Summary Report | CureHunter

Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular ... New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. ... and the immune response elicited by CORNEAL TRANSPLANTATION. ... and the corneal angiogenesis model also showed a significant ... Angiogenesis, Corneal; Corneal Neovascularizations; Neovascularization, Corneal; Neovascularizations, Corneal; Corneal ...
more infohttp://www.curehunter.com/public/keywordSummaryD016510-Corneal-Neovascularization.do

Vascular Endothelial Growth Factor A Inhibitor | GreenMedInfoVascular Endothelial Growth Factor A Inhibitor | GreenMedInfo

... application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis ... Diseases : Corneal Neovascularization. Pharmacological Actions : Anti-Angiogenic, NF-kappaB Inhibitor, Vascular Endothelial ... Diseases : Corneal Neovascularization. Pharmacological Actions : Matrix Metalloproteinases Inhibitors, Vascular Endothelial ... Curcumin may be useful as an angiogenic inhibitor in the treatment of corneal diseases that show neovascularization.Jan 01, ...
more infohttp://www.greenmedinfo.com/pharmacological-action/vascular-endothelial-growth-factor-inhibitor

Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival - Full Text View - ClinicalTrials.govSafety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival - Full Text View - ClinicalTrials.gov

Neovascularization, Pathologic. Corneal Neovascularization. Metaplasia. Pathologic Processes. Corneal Diseases. Eye Diseases. ... Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. Growth Inhibitors. ... Corneal Neovascularization Corneal Graft Failure Drug: Avastin® (bevacizumab) Drug: 0.9% NaCl & Refresh Liquigel Phase 1 Phase ... High-Risk Corneal Transplantation. Penetrating Keratoplasty. Neovascularization. Corneal Blood Vessels. Avastin. Bevacizumab. ...
more infohttps://clinicaltrials.gov/show/NCT01072357

US20070134244A1 - Combination treatment for pathologic ocular angiogenesis 
        - Google PatentsUS20070134244A1 - Combination treatment for pathologic ocular angiogenesis - Google Patents

... such as age-related macular degeneration and choroidal neovascularization. The combination therapy of the invention includes ... corneal neovascularization, neovascularization resulting from combined vitrectomy and lensectomy, retinal ischemia, choroidal ... The effect of topical bevacizumab on corneal neovascularization. Inan et al. 2007. Preclinical safety evaluation of ... Pathologic ocular angiogenesis, which includes posterior segment neovascularization, occurs as a cascade of events that ...
more infohttps://patents.google.com/patent/US20070134244A1/en

Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in RabbitsEffect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits

... corneal collagen cross-linking, CXL) on corneal neovascularization (CNV) in a rabbit alkali burn model. ,i,Methods,/i,. A total ... CNV area, corneal edema, and corneal epithelial defects were observed on days 4, 7, 10, and 14 after injury. Western blot was ... i,Results,/i,. CXL treatment decreased CNV and corneal edema in all groups compared to Group A. On day 7, MMP-9 expression was ... i,Conclusions,/i,. Our results indicate that riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, ...
more infohttps://www.hindawi.com/journals/joph/2018/7325483/

Molecular Vision: Multi-gene targeted antiangiogenic therapies
for experimental corneal neovascularizationMolecular Vision: Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization

... inhibits corneal neovascularization in different rabbit models of corneal angiogenesis. Invest Ophthalmol Vis Sci. 2009; 50: ... Corneal neovascularization (corneal NV) is a central feature in the pathogenesis of many blinding corneal disorders and is also ... Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal ... Other angiogenesis or anti-angiogenesis pathways are also important in the development of neovascularization. For example, ...
more infohttp://www.molvis.org/molvis/v16/a37/index.html

Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity | DiabetesAngiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity | Diabetes

In rabbit, corneal neovascularization induced by rabbit VAT and SAT were similar in both rate and intensity (13). In the ... Better knowledge of angiogenesis regulation in adipose tissue may allow angiogenesis inhibition to be focused on adipose tissue ... whereas inhibition of angiogenesis prevents adipose tissue development (4-6). Angiogenesis induced by adipose cells in animal ... clearly demonstrating a major role for VEGF in angiogenesis associated with adipose tissue. However, inhibition of angiogenesis ...
more infohttp://diabetes.diabetesjournals.org/content/57/12/3247

Ocular Angiogenesis | SpringerLinkOcular Angiogenesis | SpringerLink

The recent intense study of pathogenic ocular angiogenesis-an abnormal growth of blood vessels in the eye responsible for the ... Control of Neovascularization and Cell Survival in the Eye by PEDF Joyce Tombran-Tink, Colin J. Barnstable ... The recent intense study of pathogenic ocular angiogenesis-an abnormal growth of blood vessels in the eye responsible for the ... In Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics, leading academic and pharmaceutical researchers and clinicians ...
more infohttps://link.springer.com/book/10.1007/978-1-59745-047-8

nature.com searchnature.com search

Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an in vivo rabbit ... for article Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an ,i ...
more infohttp://www.nature.com/search?author=%22S%20W%20Park%22&error=cookies_not_supported&code=91a41439-ba5f-4e8f-b8de-b2e1a26d7498

Traditional Chinese Medicine and Its Significance | OMICS InternationalTraditional Chinese Medicine and Its Significance | OMICS International

2014) Phytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Mice. Altern Integr Med 3 ...
more infohttps://www.omicsonline.org/open-access/traditional-chinese-medicine-and-its-significance-2161-0444.1000001-R.php?aid=39073

RFA-RM-18-036: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and...RFA-RM-18-036: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and...

Similarly, tools to further dissect the biology of galectins in ocular angiogenesis and corneal neovascularization are desired. ... The National Eye Institute encourages development of technologies and tools that help in facile analysis of retinal, corneal ... Computational tools to understand the roles of glycans/glycosaminoglycans in systems biology such as angiogenesis, coagulation ...
more infohttps://grants.nih.gov/grants/guide/rfa-files/RFA-RM-18-036.html

Herpes Simplex Virus Keratitis: A Treatment Guideline - 2014 - American Academy of OphthalmologyHerpes Simplex Virus Keratitis: A Treatment Guideline - 2014 - American Academy of Ophthalmology

... case reports demonstrating the safety and efficacy of angiogenesis inhibitors for the treatment of corneal neovascularization ... Recently, there has been interest in the use of bevacizumab and ranibizumab for the treatment of corneal neovascularization,100 ... One case report describes the beneficial effect of bevacizumab in a patient with corneal neovascularization after HSV keratitis ... Herpes simplex virus is a common cause of corneal disease and is the leading infectious cause of corneal blindness among ...
more infohttps://www.aao.org/clinical-statement/herpes-simplex-virus-keratitis-treatment-guideline
  • Le VNH, Hou Y, Horstmann J, Bock F, Cursiefen C (2018) Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein. (for2240.de)
  • Pre- and up to 3 weeks post-induction, corneas were noninvasively examined by laser-scanning in vivo corneal confocal microscopy (IVCM) using only endogenous contrast. (diva-portal.org)
  • On November 7, 2016 , the US Food and Drug Administration granted aganirsen an Orphan Drug Designation for Prevention of Corneal Graft Rejection. (genesignal.com)
  • Notara M, Lentzsch A, Coroneo M, Cursiefen C (2018) The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure. (for2240.de)
  • Photodynamic Therapy Leads to Time-Dependent Regression of Pathologic Corneal (Lymph)Angiogenesis and Promotes High-Risk Corneal Allograft Survival. (for2240.de)
  • Wu RY, Zheng YF, Wong TY, Cheung CY, Loon SC, Chauhan BC, Aung T. Relationship of central corneal thickness with optic disc parameters: the Singapore Malay eye study. (snec.com.sg)
  • One of the processes that is vital to tumor growth and progression is angiogenesis, or the formation of new blood vessels from preexisting vasculature. (mafiadoc.com)
  • Png E, Samivelu GK, Yeo SH, Chew J, Chaurasia SS, Tong L. Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells. (snec.com.sg)