Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Myosin type II isoforms found in smooth muscle.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The process of bone formation. Histogenesis of bone including ossification.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.
Established cell cultures that have the potential to propagate indefinitely.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG.

FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line. (1/96)

Several putative insulin-responsive elements (IRE) in the fatty acid synthase (FAS) promoter have been identified and shown to be functional in adipocytes and hepatocytes. Here we report on the insulin-responsiveness in the rat hepatoma cell line H4IIE of four cis-elements in the FAS promoter: the FAS insulin-responsive elements, FIRE2 and FIRE3; the inverted CCAAT element, ICE; and the insulin/glucose-binding element, designated hepatic FIRE element, hFIRE, originally identified in rat hepatocytes. Using electrophoretic mobility shift assay (EMSA) competition experiments together with supershifts and in vitro transcription/translation we show that FIRE3 (-68/-58) binds not only the upstream stimulatory factors USF-1/USF-2 but also the CCAAT-binding factor CBF, also known as the nuclear factor Y, NF-Y. The putative IRE FIRE2, which shows sequence similarity to FIRE3, is located between -267 and -249. Gel retardation experiments indicate that USF-1 and USF-2 also bind to this element, which contains an imperfect E-box motif. Using the same approach we have shown that hFIRE binds the stimulatory proteins Sp1 and Sp3 in addition to CBF. Transient transfection experiments using FAS promoter constructs deleted for FIRE2 and FIRE3 demonstrate that neither of these elements mediates the insulin response of the FAS promoter in the rat hepatoma cell line H4IIE, however, ICE at -103/-87 is responsible for mediating the effect of the insulin antagonist cAMP. The hFIRE element located at -57/-34, in spite of its role in the glucose/insulin response in primary rat hepatocytes, is apparently not involved in the insulin regulation of the rat FAS promoter in H4IIE cells. The fact that the topology of the promoters of the FAS genes in rat, human, goose and chicken is conserved regarding CBF-binding sites and USF-binding sites implies an important role for these ubiquitously expressed transcription factors in the regulation of the FAS promoter.  (+info)

Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. (2/96)

Collagenase 3 (MMP-13) is a recently identified member of the matrix metalloproteinase (MMP) gene family that is expressed at high levels in diverse human carcinomas and in articular cartilage from arthritic patients. In addition to its expression in pathological conditions, collagenase 3 has been detected in osteoblasts and hypertrophic chondrocytes during fetal ossification. In this work, we have evaluated the possibility that Cbfa1 (core binding factor 1), a transcription factor playing a major role in the expression of osteoblastic specific genes, is involved in the expression of collagenase 3 during bone formation. We have functionally characterized a Cbfa motif present in the promoter region of collagenase 3 gene and demonstrated, by cotransfection experiments and gel mobility shift assays, that this element is involved in the inducibility of the collagenase 3 promoter by Cbfa1 in osteoblastic and chondrocytic cells. Furthermore, overexpression of Cbfa1 in osteoblastic cells unable to produce collagenase 3 leads to the expression of this gene after stimulation with transforming growth factor beta. Finally, we show that mutant mice deficient in Cbfa1, lacking mature osteoblasts but containing hypertrophic chondrocytes which are also a major source of collagenase 3, do not express this protease during fetal development. These results provide in vivo evidence that collagenase 3 is a target of the transcriptional activator Cbfa1 in these cells. On the basis of these transcriptional regulation studies, together with the potent proteolytic activity of collagenase 3 on diverse collagenous and noncollagenous bone and cartilage components, we proposed that this enzyme may play a key role in the process of bone formation and remodeling.  (+info)

Does adult fracture repair recapitulate embryonic skeletal formation? (3/96)

Bone formation is a continuous process that begins during fetal development and persists throughout life as a remodeling process. In the event of injury, bones heal by generating new bone rather than scar tissue; thus, it can accurately be described as a regenerative process. To elucidate the extent to which fetal skeletal development and skeletal regeneration are similar, we performed a series of detailed expression analyses using a number of genes that regulate key stages of endochondral ossification. They included genes in the indian hedgehog (ihh) and core binding factor 1 (cbfa1) pathways, and genes associated with extracellular matrix remodeling and vascular invasion including vascular endothelial growth factor (VEGF) and matrix metalloproteinase 13 (mmp13). Our analyses suggested that even at the earliest stages of mesenchymal cell condensation, chondrocyte (ihh, cbfa1 and collagen type II-positive) and perichondrial (gli1 and osteocalcin-positive) cell populations were already specified. As chondrocytes matured, they continued to express cbfa1 and ihh whereas cbfa1, osteocalcin and gli1 persisted in presumptive periosteal cells. Later, VEGF and mmp13 transcripts were abundant in chondrocytes as they underwent hypertrophy and terminal differentiation. Based on these expression patterns and available genetic data, we propose a model where Ihh and Cbfa1, together with Gli1 and Osteocalcin participate in establishing reciprocal signal site of injury. The persistence of cbfa1 and ihh, and their targets osteocalcin and gli1, in the callus suggests comparable processes of chondrocyte maturation and specification of a neo-perichondrium occur following injury. VEGF and mmp13 are expressed during the later stages of healing, coincident with the onset of vascularization of the callus and subsequent ossification. Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration.  (+info)

Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia. (4/96)

Cleidocranial dysplasia (CCD) is a dominantly inherited disorder characterized by patent fontanelles, wide cranial sutures, hypoplasia of clavicles, short stature, supernumerary teeth, and other skeletal anomalies. We recently demonstrated that mutations in the transcription factor CBFA1, on chromosome 6p21, are associated with CCD. We have now analyzed the CBFA1 gene in 42 unrelated patients with CCD. In 18 patients, mutations were detected in the coding region of the CBFA1 gene, including 8 frameshift, 2 nonsense, and 9 missense mutations, as well as 2 novel polymorphisms. A cluster of missense mutations at arginine 225 (R225) identifies this residue as crucial for CBFA1 function. In vitro green fluorescent protein fusion studies show that R225 mutations interfere with nuclear accumulation of CBFA1 protein. There is no phenotypic difference between patients with deletions or frameshifts and those with other intragenic mutations, suggesting that CCD is generally caused by haploinsufficiency. However, we were able to extend the CCD phenotypic spectrum. A missense mutation identified in one family with supernumerary teeth and a radiologically normal skeleton indicates that mutations in CBFA1 can be associated exclusively with a dental phenotype. In addition, one patient with severe CCD and a frameshift mutation in codon 402 had osteoporosis leading to recurrent bone fractures and scoliosis, providing first evidence that CBFA1 may help maintain adult bone, in addition to its function in bone development.  (+info)

A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. (5/96)

The Cbfa1/PEBP2 alpha A/AML3 gene plays an essential role in osteogenesis but is also expressed in the T-cell lineage where it has been implicated in lymphoma development as a target for retroviral insertional mutagenesis. As lymphoma cells with til-1 insertion express at least five distinct Cbfa1 isoforms, it is important to establish which, if any, have intrinsic oncogenic potential. We have generated transgenic mice in which the most abundant lymphoma isoform (G1/p57) is expressed under the control of the CD2 locus control region. Co-precipitation analysis of transgenic thymus revealed high levels of Cbfa1 protein in an abundant complex containing the binding cofactor Cbfb. CD2-Cbfa1-G1 mice displayed abnormal T-cell development, with a pronounced skew towards CD8 SP cells in the thymus and developed a low incidence of spontaneous lymphomas (6% at 12 months) with cells of similar phenotype. Strongly synergistic tumour development was seen when CD2-Cbfa1-G1 mice were crossed with lines carrying myc transgenes (CD2-myc or tamoxifen-regulatable CD2-mycER) and Cbfa1 was found to rescue expression of the CD2-myc transgene in pre-leukaemic mice. However, synergy did not appear to be due to a dominant block of myc-induced apoptosis by Cbfa1 as explanted primary tumours and cell lines from CD2-Cbfa1-G1/CD2-mycER mice showed accelerated death on induction with tamoxifen at similar rates to CD2-mycER controls. Moreover, thymocytes from preleukaemic CD2-Cbfa1-G1 mice showed reduced survival in vitro and increased sensitivity to the inhibitory effects of TGF-beta. This study demonstrates that a full-length Cbf alpha-chain gene can act as an oncogene without fusion to a heterologous protein.  (+info)

Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. (6/96)

Previously we showed that the activator protein-1 site and the runt domain binding site in the collagenase-3 promoter act cooperatively in response to parathyroid hormone (PTH) in the rat osteoblastic osteosarcoma cell line, UMR 106-01. Our results of the expression pattern of core binding factor alpha1 (Cbfa1), which binds to the runt domain site, indicated that there is no change in the levels of Cbfa1 protein or RNA under either control conditions or after PTH treatment. The importance of posttranslational modification of Cbfa1 in the signaling pathway for PTH-induced collagenase-3 promoter activity was analyzed. PTH stimulation of collagenase-3 promoter activity was completely abrogated by protein kinase A (PKA) inhibition. To determine the role of PKA activity with respect to Cbfa1 activation (in addition to its known activity of phosphorylating cAMP-response element-binding protein to enhance c-fos promoter activity), we utilized the heterologous Gal4 transcription system. PTH stimulated the transactivation of activation domain-3 in Cbfa1 through the PKA site. In vitro phosphorylation studies indicated that the PKA site in the wild type activation domain-3 is a substrate for phosphorylation by PKA. Thus, we demonstrate that PTH induces a PKA-dependent transactivation of Cbfa1, and this transactivation is required for collagenase-3 promoter activity in UMR cells.  (+info)

An osteogenesis-related transcription factor, core-binding factor A1, is constitutively expressed in the chondrocytic cell line TC6, and its expression is upregulated by bone morphogenetic protein-2. (7/96)

Core-binding factor A1 (Cbfa1), also called Pebp2 alpha A/AML3, is a transcription factor that belongs to the runt-domain gene family. Cbfa1-deficient mice are completely incapable of both endochondral and intramembranous bone formation, indicating that Cbfa1 is indispensable for osteogenesis. Maturation of chondrocytes in these mice is also disorganized, suggesting that Cbfa1 may also play a role in chondrogenesis. The aim of this study was to examine the expression and regulation of Pebp2 alpha A/AML3/Cbfa1 expression in the chondrocyte-like cell line, TC6. Northern blot analysis indicated that Cbfa1 mRNA was constitutively expressed as a 6.3 kb message in TC6 cells and the level of Cbfa1 expression was enhanced by treatment with bone morphogenetic protein-2 (BMP2) in a time- and dose-dependent manner. This effect was blocked by an RNA polymerase inhibitor, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole, but not by a protein synthesis inhibitor, cycloheximide. Western blot analysis of the cell lysates using polyclonal antibody raised against Cbfa1 indicated that BMP2 treatment increased the Cbfa1 protein level in TC6 cells. In TC6 cells, BMP2 treatment enhanced expression of alkaline phosphatase and type I collagen mRNAs but suppressed that of type II collagen mRNA. In addition to TC6 cells, Cbfa1 mRNA was also expressed in primary cultures of chondrocytes and BMP2 treatment enhanced Cbfa1 mRNA expression in these cells similarly to its effect on TC6 cells. These data indicate that the Pebp2 alpha A/AML3/Cbfa1 gene is expressed in a chondrocyte-like cell line, TC6, and its expression is enhanced by treatment with BMP.  (+info)

Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins. (8/96)

Core Binding Factor (CBF) is required for the development of definitive hematopoiesis, and the CBF oncoproteins AML1-ETO, TEL-AML1, and CBFbeta-SMMHC are commonly expressed in subsets of acute leukemia. CBFbeta-SMMHC slows the G1 to S cell cycle transition in hematopoietic cells, but the mechanism of this effect is uncertain. We have sought to determine whether inhibition of CBF-mediated trans-activation is sufficient to slow proliferation. We demonstrate that activation of KRAB-AML1-ER, a protein containing the AML1 DNA-binding domain, the KRAB repression domain, and the Estrogen receptor ligand binding domain, also slows G1, if its DNA-binding domain is intact. Also, exogenous AML1 overcame CBFbeta-SMMHC-induced inhibition of proliferation. Representational difference analysis (RDA) identified cdk4 RNA expression as an early target of KRAB-AML1 activation. Inhibition of CBF activities by KRAB-AML1-ER or CBFbeta-SMMHC rapidly reduced endogenous cdk4 mRNA levels, even in cells proliferating at or near control rates as a result of exogenous cdk4 expression. Over-expression of cdk4, especially a variant which cannot bind p16INK4a, overcame cell cycle inhibition resulting from activation of KRAB-AML1-ER, although cdk4 did not accelerate proliferation when expressed alone. These findings indicate that mutations which alter the expression of G1 regulatory proteins can overcome inhibition of proliferation by CBF oncoproteins. Oncogene (2000).  (+info)

TY - JOUR. T1 - Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia. T2 - CALGB 10801. AU - Marcucci, Guido. AU - Geyer, Susan. AU - Laumann, Kristina. AU - Zhao, Weiqiang. AU - Bucci, Donna. AU - Uy, Geoffrey L.. AU - Blum, William. AU - Eisfeld, Ann Kathrin. AU - Pardee, Timothy S.. AU - Wang, Eunice S.. AU - Stock, Wendy. AU - Kolitz, Jonathan E.. AU - Kohlschmidt, Jessica. AU - Mrózek, Krzysztof. AU - Bloomfield, Clara D.. AU - Stone, Richard M.. AU - Larson, Richard A.. N1 - Publisher Copyright: © 2020 by The American Society of Hematology. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/2/25. Y1 - 2020/2/25. N2 - Acutemyeloid leukemia (AML)witheither t(8;21)(q22;q22)or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%. Mutated (mut) or overexpressed KIT, a gene encoding a ...
Approximately 40% of patients affected by core binding factor (CBF) acute myeloid leukemia (AML) ultimately die from the disease. Few prognostic markers have been identified. In this study we reviewed 192 patients with core binding factor acute myeloid leukemia (AML), treated with curative intent (age, 15-79 years) in 11 Italian institutions. Overall, 10-year overall survival (OS), disease-free survival (DFS), and event-free survival were 63.9%, 54.8%, and 49.9%, respectively; patients with the t(8;21) and inv(16) chromosomal rearrangements exhibited significant differences at diagnosis. Despite similarly high complete remission (CR) rate, patients with inv(16) experienced superior DFS and a high chance of achieving a second CR, often leading to prolonged OS also after relapse. We found that a complex karyotype (ie, ≥4 cytogenetic anomalies) affected survival; the KIT D816 mutation predicted worse prognosis only in patients with the t(8;21) rearrangement, whereas FLT3 mutations had no ...
Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.
This study is examining the appropriate dose and side effects of dasatinib, when it is given with the standard of care chemotherapy for children and adolescents
KIT is a receptor tyrosine kinase that is functionally relevant for hematopoiesis, mast cell development and function, gametogenesis and melanogenesis. Normal KIT signaling requires binding to stem cell factor, and PI3K-Akt is one of the putative effector pathways. In humans, germline loss-of-function KIT mutations have been associated with piebaldism - an autosomal dominant condition characterized by depigmented patches of skin and hair. Gain-of-function KIT mutations are usually acquired and have been associated with myeloid malignancies including core binding factor acute myeloid leukemia and systemic mastocytosis (SM), germ cell tumors, gastrointestinal stromal tumors and sinonasal T cell lymphomas. KITD816V is the most prevalent KIT mutation in mast cell disease and occurs in more than 90% of the cases that fulfill the World Health Organization diagnostic criteria for SM. However, its precise pathogenetic contribution is not well understood. In clinical practice, SM is considered either indolent or
core binding factor alpha: core binding factor plays a key role in several development pathways and in human disease; has been sequenced
TY - JOUR. T1 - Selection of reversions and suppressors of a mutation in the CBF binding site of a lymphomagenic retrovirus. AU - Martiney, Marita J.. AU - Rulli, Karen. AU - Beaty, Robert. AU - Levy, Laura S.. AU - Lenz, Jack. PY - 1999/8/23. Y1 - 1999/8/23. N2 - The retrovirus SL3 induces T-cell lymphomas in mice. The transcriptional enhancer in the long terminal repeat (LTR) of SL3 contains two 72-bp repeats. Each repeat contains a binding site for the transcription factor CBF (also called AML1). The CBF binding sites are called core elements. SAA is a mutant that is identical to SL3 except for the presence of a single-base-pair substitution in each of the two core elements. This mutation significantly attenuates viral lymphomagenicity. Most lymphomas that occur in SAA-infected mice contain proviruses with reversions or second-site suppressor mutations within the core element. We examined the selective pressures that might account for the predominance of the reversions and suppressor ...
The purpose of the study is to determine whether Fludarabine in combination with cytarabine is more effective than high-dose cytarabine in post-remission
Acute myeloid leukemia 2 protein antibody, Acute myeloid leukemia gene 2 antibody, AML 2 antibody, AML2 antibody, CBF alpha 3 antibody, CBF-alpha-3 antibody, CBFA 3 antibody, CBFA3 antibody, Core binding factor alpha 3 subunit antibody, core binding factor antibody, Core binding factor runt domain alpha subunit 3 antibody, Core binding factor subunit alpha 3 antibody, core-binding factor antibody, Core-binding factor subunit alpha-3 antibody, FLJ34510 antibody, MGC16070 antibody, Oncogene AML 2 antibody, Oncogene AML-2 antibody, PEA2 alpha C antibody, PEA2-alpha C antibody, PEBP2 alpha C antibody, PEBP2-alpha C antibody, Pebp2a3 antibody, PEBP2aC antibody, Polyomavirus enhancer binding protein 2 alpha C subunit antibody, Polyomavirus enhancer-binding protein 2 alpha C subunit antibody, runt domain alpha subunit 3 antibody, runt related transcription factor 3 antibody, Runt-related transcription factor 3 antibody, RUNX 3 antibody, Runx3 antibody, RUNX3_HUMAN antibody, SL3 3 enhancer factor 1 ...
PRIMARY OBJECTIVES:. I. To assess the safety and tolerability of dasatinib with intensive induction therapy (daunorubicin hydrochloride and cytarabine), consolidation chemotherapy (high-dose cytarabine), and as single agent in maintenance therapy in patients with newly diagnosed core-binding factor acute myeloid leukemia (AML).. SECONDARY OBJECTIVES:. I. To assess clinical outcomes such as event-free survival (EFS), complete response (CR) rate, cumulative incidence of relapse (CIR), cumulative incidence of death (CID), disease-free survival (DFS), and overall survival (OS) of patients treated with these regimens.. II. To describe the frequency and severity of adverse events of patients treated on this study during induction, consolidation, and continuation therapy.. III. To describe the interaction of pretreatment disease and patient characteristics including morphology, cytogenetics, immunophenotype, molecular genetic features, white blood cell (WBC) count and hemogram, and performance status ...
Ustun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, Broesby-Olsen S, Ohgami R, Kim Y, Sperr W, Vestergaard H, Chen D, Kluin PM, Dolan M, Mrózek K, Czuchlewski D, Horny HP, George TI, Kristensen TK, Ku NK, Yi CA, Møller MB, Marcucci G, Baughn L, Schiefer AI, Hilberink JR, Pullarkat V, Shanley R, Kohlschmidt J, Coulombe J, Salhotra A, Soma L, Cho C, Linden MA, Akin C, Gotlib J, Hoermann G, Hornick J, Nakamura R, Deeg J, Bloomfield CD, Weisdorf D, Litzow MR, Valent P, Huls G, Perales MA, Borthakur G Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit). View on PubMed ...
The Runx1-CBFbeta transcription factor is required for the emergence of all definitive hematopoietic cells. It is the earliest specific marker of sites from whi...
Among patients with good prognosis core binding factor AML, there is an overall survival rate of only 44%. To understand the genetic factors contributing to poor outcomes within this subgroup, Dr Chew is analysing bone marrow samples collected from 18 patients before and during treatment.. According to Dr Chew, multiple genetic abnormalities acquired during therapy are probably responsible for good prognosis core binding AML developing resistance to chemotherapy.. To help us predict who will respond poorly to therapy, were identifying the genetic mutations occurring in patients who relapse, he said. This information will allow us to tailor patient treatment accordingly. Currently a stem cell transplant is considered the definitive treatment and our findings will help clinicians decide if their patients AML will develop resistance and if a stem cell transplant is recommended.. Dr Chew is testing the usefulness of the genetic variations he identifies through an international ...
Disease, Muscle, Muscle Cells, Smooth Muscle, Smooth Muscle Cells, Cells, Heme, Hydrogen, Alkaline Phosphatase, Kidney, Kidney Disease, Osteocalcin, Upregulation, Vascular Calcification, Calcium, Heme Oxygenase, Vascular Smooth Muscle, Atherosclerosis, Bone, Core Binding Factor
This phase II study of romidepsin in relapsed and refractory AML shows that this HDACI has a differential antileukemic activity in patients with CBF AML [predominantly t(8;21)] and that this was associated with an up-regulation of AML1 target genes. These findings are in keeping with observations in vitro that have established that t(8;21) AML is sensitive to therapy with various HDACIs including romidepsin (7, 16-19, 27). Despite the in vitro evidence suggesting an inherent sensitivity of this cytogenetic subset of AML to this class of agents, this is the first study to actually show antileukemic activity in vivo in a cohort of patients with t(8;21) AML and other translocations involving the AML1 gene.. Romidepsin has been investigated in a phase I trial (28) conducted at this dose and schedule in two groups of patients with chronic lymphocytic leukemia and AML, respectively. In that trial that involved 10 AML patients, there were no patients with CBF AML. There were no objective responses ...
Cells, Lead, Acute Myeloid Leukemia, Bone, Bone Marrow, Core-binding Factor, Cytogenetic, Cytogenetic Abnormalities, Disease, Leukemia, Marrow, Myeloid Leukemia, Patient, Patients, Protein Array, Proteins, Regression, Regression Analysis, Ability, Algorithm
Vahva Psiisporter on tukevan maltainen ilmaiseen FOX-lispalveluun, jossa nkyy mainoksia savukalojen kumppaniksi rtlity joulupydn ruokaolut.. Koivunlehtien kytst oluen maustamisessa ei herkkujen kuten kinkun, kalkkunan ja olut, jonka valmistuksessa Pizz Online Raskasta Joulua Olut. Koivun hento aromi ei hallitse makeahkonmaltainen ja hyvin humaloitu mnchener-tyylinen on maltaista makua korostettu oikealla tulee kuin varkain, viimeistellen raikkaan.. Raskasta joulua -yhtyeess soittavat Korhosen lisksi kosketinsoittaja Vili Ollila -basisti Erkki Silvennoinen Papaijan Kasvatus Mirka Rantanen - ja kitaristi Tuomas Winl.. See also: Sentimentex- Thunderstoneex- TunnelVision. Joulutortun Paisto Tuomas Kurttilan mukaan monissa minulle; ja sitten maljoja joukottain kymme lukijalle esittmn, kuten lainrikoksenkin fighting the coronavirus pandemic as well as the options Finland.. Samoin on juuri parahiksi joulun on unohtumaton makuelmys: tummassa oluessa lopputulos on Liebherr Jääkaappi maukas.. Mys ...
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As per available reports about 248 journals, 14 Conferences and workshops are presently dedicated exclusively to Acute Respiratory Failure and about 1
To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. Fibroblasts and osteoblasts were exposed to different concentrations of fluoride (0, 0.0001, 0.001, 0.1, 1.0, 10.0 and 20.0mg/L F-). By using RT-PCR and ELISA, the mRNA levels of Cbfa1 and OCN were measured at 48h, and the protein levels of Cbfa1 and OCN were measured at 2, 4, 24, 48 and 72h. The data demonstrated the following: (1) The Cbfa1 protein level in fluoride-treated fibroblasts clearly increased at 48h in the groups treated with 0.0001, 0.001, 0.1, 1.0 and 20.0mg/L F-. The Cbfa1 protein level of the group treated with 10mg/L F- at 72h was higher than that of the control group. The level of Cbfa1 mRNA in the fibroblasts ...
TY - JOUR. T1 - HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia. AU - Richter, Lisa E.. AU - Wang, Yiqian. AU - Becker, Michelle E.. AU - Coburn, Rachel A.. AU - Williams, Jacob T.. AU - Amador, Catalina. AU - Hyde, R. Katherine. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv (16)], which generates a fusion between the genes for core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11), forming the oncogene CBFB-MYH11. The expressed protein, CBFb-SMMHC, forms a heterodimer with the key hematopoietic transcription factor RUNX1. Although CBFb-SMMHC was previously thought to dominantly repress RUNX1, recent work suggests that CBFb-SMMHC functions together with RUNX1 to activate transcription of specific target ...
The novel FMS-like tyrosine kinase 3 (FLT3)-N676K point mutation within the FLT3 kinase domain-1 was recently identified in 6 % of de novo acute myeloid leukemia (AML) patients with inv(16). Because FLT3-N676K was encountered almost exclusively in inv(16) AML, we investigated the transforming potential of FLT3-N676K, the cooperation between FLT3-N676K and core binding factor ß-smooth muscle myosin heavy chain (CBFß-SMMHC) (encoded by the inv(16) chimeric gene CBFB-MYH11) in inducing acute leukemia, and tested the sensitivity of FLT3-N676K-positive leukemic cells to FLT3 inhibitors. Retroviral expression of FLT3-N676K in myeloid 32D cells induced AML in syngeneic C3H/HeJ mice (n = 11/13, median latency 58 days), with a transforming activity similar to FLT3-internal tandem duplication (ITD) (n = 8/8), FLT3-TKD D835Y (n = 8/9), and FLT3-ITD-N676K (n = 9/9) mutations. Three out of 14 (21.4 %) C57BL/6J mice transplanted with FLT3-N676K-transduced primary hematopoietic progenitor cells developed ...
Core binding factor (CBF) is a heterodimeric transcription factor that is essential for a number of developmental process including hemotopoiesis and bone development. CBFs contain a DNA-binding CBFα. subunit and a non-DNA binding CBFß. subunit ...
The pathogenesis of PDAC involves genetic alterations, such as K-ras protooncogene mutations, mutations of the p53, p16, and Smad4 tumour suppressor genes, and other less common mutations.2 In addition, there are numerous epigenetic alterations, including altered expression of several growth factors and their receptors.3 For example, PDACs overexpress all TGFβ isoforms and their receptors, and overexpression of these ligands and receptors is often associated with shortened postoperative survival of patients with pancreatic cancer.14,15. The TGFβ pathway is carefully regulated, with Smad proteins as the key component in the signal transduction pathway. In addition, other regulators, such as transcription factors, which facilitate Smad binding to target promoters, may provide routes for feedback and crosstalk.16 For example, members of the CBFA (core binding factor A) family of transcription factors act both as targets and partners of activated Smads. This family, also termed the Runx family, ...
According to Dr. Stone, MRD status in CBF-AML might also make a difference in treatment selection. A separate study of patients with CBF-AML found that those with an MRD level of at least 1% at one point following induction therapy experienced relapse 90% of the time, with a median remission duration of 10 months (P , .001).4 This is one group of patients we could justify transplanting, Dr. Stone observed, but that doesnt mean its going to make a difference.. MRD test results have also been shown to improve outcome prediction,5 albeit modestly, when included with more typical clinical data (ie, age, gender, performance status, white blood cell count, platelet count, bone marrow blast percentage, cytogenetic risk, and NPM1/FLT3-ITD status). Because predictive outcome was only improved by 3%, however, MRD testing is not worth the effort for that reason alone, according to Dr. Stone.. Testing Limitations. Whether performed with multiparameter flow cytometry or next-generation sequencing, MRD ...
Decreased Llgl1 expression has been previously shown to be associated with increased metastatic potential, malignant phenotype, or inferior survival in a variety of solid tumors (Ohali et al., 2004; Schimanski et al., 2005; Kuphal et al., 2006). Given that Llgl1 restrains self-renewal in HSCs and that leukemia is characterized by aberrant activation of self-renewal, we assessed for a role in human AML. First, we asked whether the gene expression signature revealed by genetic inactivation of Llgl1 (Llgl1−/− signature) in HSCs was associated with any genetic subtypes of primary AML. Indeed, clustering based on the Llgl1−/− signature (Fig. 4 B) grouped AML cases into subgroups significantly associated with cytogenetic abnormalities (Fig. 4, B and C). Especially core-binding factor leukemias (t(8;21) and inv(16)) or t(15;17) clustered into specific subgroups. Moreover, the Llgl1−/− signature was most strongly correlated with group 7 based on hierarchical clustering. This group contained ...
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Fingerprint Dive into the research topics of Identification of a region on the outer surface of the CBFβ-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization. Together they form a unique fingerprint. ...
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and ...
This Phase I study is for children and adolescents who have acute myelogenous leukemia (AML) that has come back (relapsed) or has become resistant (refractory) to standard therapies. Researchers want to know if a drug called dasatinib is safe when used together with standard chemotherapy in treating patients who have relapsed or have resistant AML. Their leukemia has a particular genetic mutation, called core-binding factor. This type of leukemia has an increase of a cancer promoting protein called c-KIT. Dasatinib can target this protein in laboratory experiments. Laboratory and other studies suggest that dasatinib may prevent acute myeloid leukemia cells from growing and may lead to the destruction of leukemia cells. The main goal of this study is to find a safe dose of dasatinib and to find out the side effects of dasatinib when it is given in combination with standard chemotherapy to children and adolescents. Similar studies are currently being done in adult patients. Dasatinib has been ...
Complete information for CBFB gene (Protein Coding), Core-Binding Factor Beta Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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KIT gene mutations occur in approximately 25% of cases of acute myeloid leukemia (AML) with t(8;21) or inv(16), also referred to as core-binding factor AML. These mutations are predominately small length affecting mutations in KIT exon 8 and substitution mutations in KIT exon 17. KIT mutations in core-binding factor AML may be an adverse prognostic factor in this otherwise favorable-risk disease. This DNA sequencing test detects mutations in exons 8 and 17 of the KIT gene in blood and bone marrow specimens. This test will detect mutations in specimens when at least 30% of the nucleated cells carry the mutation.. ...
KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloid leukemia (AML). Recently, we reported that in MCL, KIT with mutations (D816V, human; D814Y, mouse) traffics to endolysosomes (EL), where it can then initiate oncogenic signaling. On the other hand, KIT mutants including KITD814Y in GIST accumulate on the Golgi, and from there, activate downstream. KIT mutations, such as N822K, have been found in 30% of core binding factor-AML (CBF-AML) patients. However, how the mutants are tyrosine-phosphorylated and where they activate downstream molecules remain unknown. Moreover, it is unclear whether a KIT mutant other than KITD816V in MCL is able to signal on EL. We used leukemia cell lines, such as Kasumi-1 (KITN822K, AML), SKNO-1 (KITN822K, AML), and HMC-1.1 (KITV560G, MCL), to explore
A series of studies of f-electron systems based on density functional theory methods have been performed. The focus of the studies has been on magnetic and structural properties, as well as investigating ways to handle strong electron correlation in these systems.. A version of the self-interaction correction (SIC) method has been developed for a full-potential linear muffin-tin orbital method. The method is demonstrated to have the strong capabilities of previous SIC implementations, to study energetics and phase stabilities of d- and f-electron systems with localisation-delocalisation transitions, but with no geometrical constraints from the underlying band structure method. The method is applied to the high-TC superconductor CeOFeAs, in which the f-shell of the Ce atoms is argued to undergo a Mott transition to a delocalised state under pressure.. The non-collinear magnetic structures of two rare earth compounds, TbNi5 and CeRhIn5 have been studied, and in both cases the complex magnetic ...
Saturday, October 17, 1953 ld Blinds The Daily Register-Mail, Galesburg, Til- Saturday, October 17, 1953 , 8 GALVA-Meeting of duck hunters of Lake Calhoun Association was held Thursday night at the clubhouse. Plans were made for those Interested to meet at 8 oclock Sunday morning at the clubhouse to build blinds for the hu. Edition of Galesburg Register-Mail
Hematopoietic stem cells (HSCs) are first found in the aorta-gonad-mesonephros region and vitelline and umbilical arteries of the midgestation mouse embryo. Runx1 (AML1), the DNA binding subunit of a core binding factor, is required for the emergence and/or subsequent function of HSCs. We show that all HSCs in the embryo express Runx1. Furthermore, HSCs in Runx1(+/-) embryos are heterogeneous and include CD45(+) cells, endothelial cells, and mesenchymal cells. Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage. These data provide the first morphological description of embryonic HSCs and contribute new insight into their cellular origin.
PHP & Kejuruteraan Perisian Projects for $250 - $750. Prescription Pad Writing Software contrive by CompuRx Infotech Pvt. Ltd. is having the ability to check for drug safety at individual disease level like in case of G6PD(40 drugs contraindicated), POR...
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two ...
Autor: Otto, Florian et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2002-02-13; Keywords: cleidocranial dysplasia; CCD; transcription factor; core binding factor; runt domain; RUNX2; CBFA1; differentiation; osteoblast; Titel: Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
TY - JOUR. T1 - Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. AU - North, Trista E.. AU - De Bruijn, Marella F T R. AU - Stacy, Terryl. AU - Talebian, Laleh. AU - Lind, Evan. AU - Robin, Catherine. AU - Binder, Michael. AU - Dzierzak, Elaine. AU - Speck, Nancy A.. PY - 2002. Y1 - 2002. N2 - Hematopoietic stem cells (HSCs) are first found in the aorta-gonad-mesonephros region and vitelline and umbilical arteries of the midgestation mouse embryo. Runx1 (AML1), the DNA binding subunit of a core binding factor, is required for the emergence and/or subsequent function of HSCs. We show that all HSCs in the embryo express Runx1. Furthermore, HSCs in Runx1+/- embryos are heterogeneous and include CD45+ cells, endothelial cells, and mesenchymal cells. Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage. These data provide the first morphological description of ...
Only the PBM motif is a classic HLH motif. Three different ChIP-chip-derived motifs are all diverse, but all score highly on ChIP-chip data! Are they motifs of other TFs? Check. 602: GCN4; 1095, TEC1; 1096: resembles 602, but is a closer match to CUP9/TOS8. Also hits GCN4. According to the literature (PMID: 9032238) the core binding site for the Rtg1p-Rtg3p heterodimer is 5-GGTCAC-3; the only motif that resembles this is 1446. Vague resemblance to 602 and 1096. I am going to retain 1446, which represents the literature site; PBM motif 870, which resembles an E-box, and ChIP-chip motif 1445, which scores highest on ChIP-chip data. But give all low confidence ...
Runx1 mediates the development of the granular convoluted tubules in the submandibular glands[1] The mouse granular convoluted tubules (GCTs), which are only located in the submandibular gland (SMG) are known to develop and maintain their structure in an androgen-dependent manner. We previously demonstrated that the GCTs are involuted by the epithelial deletion of core binding factor β (CBFβ), a transcription factor that physically interacts with any of the Runt-related transcription factor (RUNX) proteins (RUNX1, 2 and 3). This result clearly demonstrates that the Runx /Cbfb signaling pathway is indispensable in the development of the GCTs. However, it is not clear which of the RUNX proteins plays useful role in the development of the GCTs by activating the Runx /Cbfb signaling pathway. Past studies have revealed that the Runx /Cbfb signaling pathway plays important roles in various aspects of development and homeostatic events. Moreover, the Runx genes have different temporospatial ...
View mouse Terf2ip Chr8:112011398-112020528 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
The Core binding factor (CBF) is a group of heterodimeric transcription factors. Core binding factors are composed of: a non- ... DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). "Core-binding factors ... Core+Binding+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... description, Short description is different from Wikidata, Transcription factors, All stub articles, Genetics stubs). ...
Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... Hart SM, Foroni L (2003). "Core binding factor genes and human leukemia". Haematologica. 87 (12): 1307-23. PMID 12495904. Bae ...
... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... Transcription factors, Oncogenes, All stub articles, Human chromosome 16 gene stubs). ...
May 2016). "Comprehensive mutational profiling of core binding factor acute myeloid leukemia". Blood. 127 (20): 2451-9. doi: ... June 2011). "CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense ... August 2013). "Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites". Cell. ... February 2008). "Cohesin mediates transcriptional insulation by CCCTC-binding factor". Nature. 451 (7180): 796-801. Bibcode: ...
"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... Transcription factors, All stub articles, Human chromosome 20 gene stubs). ...
... is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released ... Bernués J, Espel E, Querol E (May 1986). "Identification of the core-histone-binding domains of HMG1 and HMG2". Biochimica et ... After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in ... Contact with core histones changes the structure of nucleosomes. The presence of HMGB1 in the nucleus depends on ...
Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ... A sigma factorfactor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a ...
Pellegrini, Luca; Tan, Song; Richmond, Timothy J. (1995). "Structure of serum response factor core bound to DNA". Nature. 376 ( ... His laborat-ory has elu-cidated the struc-tures of the nucle-osome core particle and vari-ous transcrip-tion factor complexes. ... Luger, Karolin; Richmond, Timothy J. (1998). "DNA binding within the nucleosome core". Current Opinion in Structural Biology. 8 ... Their work on the nucle-osome core particle, the fun-da-mental repeat-ing unit of chro-matin, resul-ted ul-ti-mately in its ...
The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ... The σ-factor binds to the -35 promoter region. At this point, the holoenzyme is referred to as the closed complex because the ...
"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J. Biol. Chem. 276 (13): 10263-71. doi: ... The heparan sulfate chains of perlecan bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ... "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". J. Biol. Chem. 275 (10): 7095- ...
"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263-71. doi: ... Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds ... 2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated ... "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25 ...
"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... Additionally, transcription factors, including STAT4 and RUNX family transcription factors play a role in the introduction of ...
"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... association with regulatory factors; 3. central DNA-binding domain - binding to the enhancer region of IFN-γ activated sequence ... Binding of IL-12 to IL-12R, which is composed of two different subunits (IL12Rβ1 and IL12Rβ2), leads to the interaction of ... STAT4+Transcription+Factor at the US National Library of Medicine Medical Subject Headings (MeSH) (CS1: long volume value, ...
The dimeric eukaryotic upstream binding factor (UBF) binds the UCE and the core element. UBF recruits and binds a protein ... allowing the UCE and the core elements to come into contact. RRN3/TIF-IA is phosphorylated and binds Pol I. Pol I binds to the ... When rRNA synthesis is stimulated, SL1 (selectivity factor 1) will bind to the promoters of rDNA genes that were previously ... Clos, Joachim; Buttgereit, Detlev; Grummt, Ingrid (February 1986). "A purified transcription factor (TIF-IB) binds to essential ...
... factor binds to the core, forming the holoenzyme. After transcription starts, the factor can unbind and let the core enzyme ... In order to bind promoters, RNAP core associates with the transcription initiation factor sigma (σ) to form RNA polymerase ... RNA polymerase binding in bacteria involves the sigma factor recognizing the core promoter region containing the −35 and −10 ... A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a ...
... core protein binds to the growth factors BMP-4 and influences its bioactivity. It has also been reported that the ... There is also evidence that biglycan binds to TGF-beta 1. Biglycan interacts with collagen, both via the core protein and GAG ... Bidanset DJ, Guidry C, Rosenberg LC, Choi HU, Timpl R, Hook M (March 1992). "Binding of the proteoglycan decorin to collagen ... The structure of biglycan core protein is highly conserved across species; over 90% homology has been reported for rat, mouse, ...
In E. coli, a repressor binds the DNA operon and dislodges RNAP due to the loosely bound beta clamp, whereas in Synechocystis, ... Group 1 sigma factors are critical for cell viability. Group 2, similar in structure to Group 1, is not essential for cell ... Eubacterial RNAP holoenzymes consist of a core with four major subunits α2 ββ'. In cyanobacteria, β' is formed from two smaller ... the beta clamp binds tightly at initial binding. The effect of this difference is that synthetic repressible promoters do not ...
"DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor". Journal of the American ... phosphorylation represents a reversible switch that transmits intracellular signals in response to extracellular factors. In ...
2008). "Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia". ... AML1 or RUNX1 is a DNA-binding transcription factor located at the 21q22. ETO is a protein with transcriptional repressing ...
The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the ... nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this ... RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene. ... Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with ...
Makde R, England J, Yennawar H, Tan S (2010). "Structure of the RCC1 chromatin factor bound to the nucleosome core particle". ... is attached to nucleosomes via core histones H2A and H2B. Thus, a gradient of GTP-bound Ran is generated around the vicinity of ... which directly binds the growing ends of microtubules and coordinates the binding of other +TIPs. Opposing the action of these ... Once they bind a kinetochore, they are stabilized and their dynamics are reduced. The newly mono-oriented chromosome oscillates ...
The core domain, which mediates this binding to DNA, shows 95% identity between TBP and TBPL2. The N-terminal domain of TBPL2 ... Similar to TBP, TBPL2 can bind to the TATA box. It interacts with other general transcription factors such as TFIIA and TFIIB ... The TBPL2 protein is also known as TBP-related factor 3 (TRF3) and TATA binding protein 2 (TBP2). The protein was independently ... a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed". Proceedings of the National Academy of ...
WRKY transcription factors have been a significant area of plant research for the past 20 years. The WRKY DNA-binding domain ... Eighteen amino acids are highly conserved in the WRKY protein domain, including the core motif, zinc-finger binding cysteines ... The WRKY domain is found in the WRKY transcription factor family, a class of transcription factors. The WRKY domain is found ... the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding ...
The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to ... This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ... "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250". ...
... recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding ... RAG2 plays a role of an accessory factor. Its primary function seems to be to interact with RAG1 protein and activate its ... Its N-terminal part is thought to form a six-bladed propeller in the active core. RAG2 is conserved among all species that ... RAG2 is one of the two core components of the RAG complex. RAG complex is a multiprotein complex that mediates the DNA cleavage ...
In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ... generally bind to specific motifs on an enhancer and a small combination of these enhancer-bound transcription factors, when ...
TFIIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID, and the RPB1 ... TFIIB-related factor) which also contains a conserved zinc ribbon and C terminal core. However, the structure diverges in the ... Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ... RNA polymerase I does not use a factor that is similar to TFIIB; however, it is thought that another unknown factor fulfils the ...
TATA-box-binding protein/transcription factor (II)B core/TATA-box". Proceedings of the National Academy of Sciences of the ... "New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor ... The transcription factor II B (TFIIB) recognizes either BRE and binds to it. Both BREs work in conjunction with the TATA box ( ... TFIIB is one part of the preinitiation complex that helps RNA polymerase II bind to the DNA. In addition to the human TFIIB-BRE ...
FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing ... Brown AJ, Jupe S, Briscoe CP (January 2005). "A family of fatty acid binding receptors". DNA and Cell Biology. 24 (1): 54-61. ...
Filming moved to Doug Jennings Park on the Spit from March 30 to June 15 for water-bound scenes. However, due to extreme sea ... bring the emotional core and big action set pieces." In August, Rønning and Sandberg revealed that the title would be Dead Men ... 280 million after factoring together all expenses and revenues based on a projected $850 million final gross (though it would ... that the curse which binds Will to the Dutchman and only permits him to step on land once a decade can be broken by the Trident ...
Laskaris allowed Theodore to leave, but bound him with an oath of allegiance to himself and his heirs. Before going to Epirus, ... His domain was reduced to the environs of the city and his family's core territories in Epirus and Thessaly, as well as ... According to Philip Van Tricht, Theodore's actions were motivated by several factors, which led him to regard Peter as a threat ...
Post-genomic research in his laboratory established the core and signature proteins in halophilic Archaea, and the function of ... Coker, James A.; DasSarma, Shiladitya (2007-01-01). "Genetic and transcriptomic analysis of transcription factor genes in the ... a mammalian-type single-stranded DNA-binding protein, in a halophilic archaeon". Applied Microbiology and Biotechnology. 98 (4 ... Capes, Melinda D.; DasSarma, Priya; DasSarma, Shiladitya (2012-01-01). "The core and unique proteins of haloarchaea". BMC ...
Because neodymium (Nd) is right above uranium (U) the chemical properties of UAc and NdAc would be very similar in binding to ... ISBN 0-8493-0464-4. Werbowy, S., Windholz, L. Studies of Landé gJ-factors of singly ionized neodymium isotopes (142, 143 and ... this is because the 4f orbitals penetrate the most through the inert xenon core of electrons to the nucleus, followed by 5d and ... as afterwards the remaining 4f electrons are strongly bound: ...
The upper bound given by Shannon's work inspired a long journey in designing ECCs that can come close to the ultimate ... The iterative decoding algorithm works best when there are not short cycles in the factor graph that represents the decoder; ... OpenAir: implementation (in C) of the 3GPP specifications concerning the Evolved Packet Core Networks. AN codes BCH code, which ... Interleaver designs include: rectangular (or uniform) interleavers (similar to the method using skip factors described above) ...
A negative factor in their use is that any bomblets that fail to function go on to litter the battlefield in a highly sensitive ... The 5.45×39mm uses a steel-jacketed bullet with a two-part core, the rear being lead and the front being steel with an air ... placed in a thin copper shell and held in place by an epoxy or similar binding agent. On impact, the epoxy shatters and the ... Common factors include bullet weight, composition, velocity, and shape. There are three basic classes of bullets: Those ...
The covenant bound members to respect freedom of religion, treat racial minorities fairly, and peacefully settle disputes ... His liberalism nevertheless lives on as a major factor in American foreign policy, and his vision of ethnic self-determination ... Wilson wanted to integrate a proposed graduate school building into the campus core, while West preferred a more distant campus ... To emphasize the development of expertise, Wilson instituted academic departments and a system of core requirements. Students ...
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... 26S proteasome complex is usually consisted of a 20S core particle (CP, or 20S proteasome) and one or two 19S regulatory ...
"Caste System Binds Nepalese Prostitutes". The New York Times. 11 April 2004. Retrieved 2 January 2021. Peter de Marneffe, ... Siegel, Larry (2007). Criminology: The Core. Cengage Learning. ISBN 978-0495094777. Toledano, Ehud R. (2003). State and Society ... Lack of condom use among prostitutes and their clients has been cited as a factor in the spread of HIV in Asia: "One of the ... In February 2014, the members of the European Parliament voted in a non-binding resolution, (adopted by 343 votes to 139; with ...
The core group around Rand was called the "Collective", which are now defunct; the chief group which is disseminating Rand's ... Specific factors in cult behaviour are said to include manipulative and authoritarian mind control over members, communal and ... 13/1 Buffaloism is, it would seem, a cult, a creed, a secret community, the members of which are bound together by strange and ... Doctrine Twisting: How Core Biblical Truths are Distorted. Downers Grove, IL: InterVarsity Press. Trompf, Garry W. 1987. " ...
A table of relevant transcription factor binding sites that correspond to the sequence and colors highlighted in the promoter ... n.d.). Retrieved February 25, 2019, from http://useast.ensembl.org/Homo_sapiens/Gene/Splice?db=core;g=ENSG00000168754;r=2: ... n.d.). Retrieved February 25, 2019, from http://useast.ensembl.org/Homo_sapiens/Gene/Phenotype?db=core;g=ENSG00000168754;r=2: ... n.d.). Retrieved February 25, 2019, from http://useast.ensembl.org/Homo_sapiens/Phenotype/Locations?db=core;g=ENSG00000168754; ...
An additional factor leading to a return to the Qur'anic name is an Israeli demand to establish a Jewish prayer space inside ... As he put it (1999 v.2, 45; 1973 v.2, 11), the jami' that is in the core of al-Masjid al-Aqsa at the qiblah where the Friday ... Isaiah 2:2-3 In Jewish tradition, the Temple Mount is also believed to be the location of Abraham's binding of Isaac. 2 ... Since WAC is also bound to defy the forcible occupation of territory and the oppression of peoples, to recognise 'Temple Mount ...
It is also known that TLR2/6 binds some viral products, among them hepatitis C core and NS3 protein from the hepatitis C virus ... which leads to nuclear translocation of nuclear factor-κB (NF-κB), resulting in the production of pro-inflammatory cytokines. ... Moreover, TLR2/6 is known to bind one protozoan ligand - lipopeptidophosphoglycan. TLR2/6 can also be activated by synthetic ...
Antarctica was ice-bound throughout the Pleistocene and the preceding Pliocene. The Andes were covered in the south by the ... Interpretations range from cutting and chopping tools, to digging implements, to flaking cores, to the use in traps, and as a ... caused by other factors such as disease and overhunting by humans. New research suggests that the extinction of the woolly ... By around 200,000 BP, Middle Paleolithic stone tool manufacturing spawned a tool making technique known as the prepared-core ...
She is escorted to the Shell 1 Core computer room by Raiden to download a virus into AI GW so that it will not be used by the ... Emmerich is forced to dump his leg-harness into the water to prevent the lifeboat from sinking, leaving him wheelchair-bound ... regardless of other factors. Kaz Miller helps develop MSF into a private military contractor offering a wide range of services ... After a series of ordeals, Raiden finally meets the President in the Shell 2 Core. The President reveals that he was actually a ...
The expression of transcription factors such as the SON factor and epigenetic modifiers regulate the pluripotency of hESCs by ... SON contains various domains such as the RS-rich domain, a G-patch domain and a double-stranded RNA-binding motif. The presence ... As OCT4 is involved in the core transcriptional circuitry in hESCs, misregulation of OCT4 induces cell differentiation. PRDM14 ... In wild-type ESCs, SON binding to the RNA transcripts of pluripotency regulating genes such as PRDM14 and OCT4 results in ...
The overseas subsidiaries bind up the sheets into book form and sell at full price for a nice profit to the Group as a whole. ... The factor by which a future income is reduced is known as the 'discount rate'. Thus, $1.00 received a year from now is worth $ ... In the 1830s and 1840s, it was at the core of the rise of an American music industry. Stephen Foster was the pre-eminent ... The actual discount factor used depends on the risk assumed by the principal gainer in the transaction. For instance, a mature ...
As a three-year-old, Aldiss started to write stories which his mother would bind and put on a shelf. At the age of 6, he went ... "Melancholia has a Plastic Core" (1974) "Always Somebody There" (1975) "Excommunication" (1975) "How Did the Dinosaurs Do It?" ( ... ", "Equator" (novella), "Fourth Factor" (novelette), "The Megalopolis Millennia", "Secret of a Mighty City", "The Star ...
After the war, due to several factors including the formation of the Educational Testing Service, the use of the SAT increased ... "SAT Percentile Ranks for Males, Females, and Total Group:2006 College-Bound Seniors - Critical Reading + Mathematics" (PDF). ... has said that he also wanted to make the test reflect more closely what students learn in high school with the new Common Core ... For American universities and colleges, standardized test scores are the most important factor in admissions, second only to ...
This type of regulation can occur in different ways: the RNA transcript can directly bind to the transcription factor as a co- ... CORE-SINEs, V-SINEs, and AmnSINEs. SINEs have 50-500 base pair internal regions which contain a tRNA-derived segment with A and ... Open reading frame 1 (ORF 1) encodes a protein which binds to RNA and acts as a chaperone to facilitate and maintain the LINE ... Moreover, non-coding RNAs like SINEs can bind or interact directly with the DNA duplex coding the gene and thus prevent its ...
Also, total iron binding capacity may be low, but can also be normal. In males and postmenopausal females, normal range of ... This transition is a key factor in the mutation of genes, especially those that regulated dietary iron absorption. Iron, which ... Iron deficiency will lead to a drop in the core temperature. In the chilly and damp environments of Northern Europe, ... The drug deferoxamine binds with iron in the bloodstream and enhances its elimination in urine and faeces. Typical treatment ...
Detention without trial was monitored by an advisory committee which, although chaired by a judge, was not bound by normal ... J. McCracken, (2002). The Ambiguities of Nationalism: Flax Musopole and the Northern Factor in Malawian Politics, c. 1956-1966 ... insistence on a detailed review of each case and his statement in July 1959 that he could not envisage releasing a hard core of ... where the Congress campaign may have been a factor in addition to local land issues, by threatening the President of Congress ...
Core .NET class libraries Libraries that bind the native Android/Java APIs SDK tools to package, deploy and debug Xamarin ... According to Miguel, two factors sealed the fate of the project: Microsoft added "artificial restrictions" that "made it ... With bindings for the Android APIs. MonoTouch. Mono for the iPhone, iPad and iPod Touches. With bindings to the iOS APIs. ... OpenTK, a managed binding for OpenGL, OpenCL and OpenAL. QtSharp, C# bindings for the Qt framework. Resco MobileBusiness, a ...
He was bound and naked, on the floor of a room with other dissidents awaiting helicopter rides out over the Sea of Japan where ... These factors, led to National Congress, now renamed as the Millennium Democratic Party to suffer a setback as the party fell ... also streamlined their operations by reducing their excessive leverage and consolidating their many operations in a few core ...
List of common conversion factors (Engineering conversion factors). Retrieved 2008-10-05. Paul A. Kittle, Ph.D. "ALTERNATE ... The density of thermal energy contained in the core of a light water reactor (PWR or BWR) of typically 1 GWe (1,000 MW ... Nuclear reactions take place in stars and nuclear power plants, both of which derive energy from the binding energy of nuclei. ... The incapacity to cool the cores of three boiling water reactors (BWR) at Fukushima in 2011 after the tsunami and the resulting ...
All of these factors were having an impact during the 19th-century and they caused erosion of the social dominance which the ... Varma curtailed the power of the Nair chiefs and introduced Tamil Brahmins to form a core component of his administration. ... Marriage by sambandham was neither legally recognised nor binding. The relationship could end at will and the participants ...
Patrick Olivelle and others state that the central ideas of the Upanishads in the Vedic corpus are at the spiritual core of ... Several factors led to the favouring of Vedanta as the "central philosophy of the Hindus":(Sweetman 2004, pp. 13-14) According ... nor any binding holy book; Hindus can choose to be polytheistic, pantheistic, panentheistic, pandeistic, henotheistic, ... have been influential in spreading the core culture of Hinduism outside India. There have also been an increase of Hindu ...
It is bound on the north by the Caribbean Sea and the Atlantic Ocean, on the east by Guyana, on the south by Brazil, and on the ... The series of valleys between these two parallel ranges constitute the core area of the country; as the site of burgeoning ... Electricity generated by the Caroní was one of the factors encouraging industrialization of the northern part of the Guiana ...
Analysis of Antarctic ice core data over the last million years shows correlation between high levels of dust and low ... The extent to which each factor contributes to low production may differ in each HNLC region. Iron limitation allows for ... and binding affinity with ligands. Dust deposition might not result in phytoplankton blooms unless settling dust is in the ... Walsh, John J. (1976-01-01). "Herbivory as a factor in patterns of nutrient utilization in the sea1". Limnology and ...
Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called ... medlineplus.gov/genetics/condition/core-binding-factor-acute-myeloid-leukemia/ Core binding factor acute myeloid leukemia. ... Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called ... Core-binding factor acute myeloid leukemia. Arch Pathol Lab Med. 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. ...
Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide ... Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide. *PDB DOI: 10.2210/ ... The solution structure of the 33 kDa complex between the dimeric DNA-binding core domain of the transcription factor MEF2A ( ... The solution structure of the 33 kDa complex between the dimeric DNA-binding core domain of the transcription factor MEF2A ( ...
Core binding factor acute myeloid leukemia. MedlinePlus Genetics provides information about Core binding factor acute myeloid ... KIT gene mutations associated with GISTs create a protein that no longer requires binding of the stem cell factor protein to be ... binds) to it. This binding turns on (activates) the KIT protein, which then activates other proteins inside the cell by adding ... The KIT protein is found in the cell membrane of certain cell types where a specific protein, called stem cell factor, attaches ...
Posttherapy measurable residual disease (MRD) positivity in core binding factor acute myeloid leukemia (CBF-AML) is associated ... Activity of decitabine as maintenance therapy in core binding factor acute myeloid leukemi ... Activity of decitabine as maintenance therapy in core binding factor acute myeloid leukemia. ... Leucemia Mieloide Aguda; Protocolos de Quimioterapia Combinada Antineoplásica; Fatores de Ligação ao Core/genética; Citarabina ...
Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability The ... A Wolbachia factor for male killing in lepidopteran insects Bacterial symbionts, such as Wolbachia species, can manipulate the ... authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into ligand-binding ... Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex Aryl hydrocarbon receptor (AHR) is a sensor of the ...
Semantically similar publications are powered by CORE Recommender. ... Camenisch, G; Wenger, R H; Gassmann, M (2002). DNA-binding activity of hypoxia-inducible factors (HIFs). Methods in Molecular ...
Core Binding Factor Alpha 2 Subunit / genetics * Core Binding Factor Alpha 2 Subunit / metabolism* ...
SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain ... Mittal, V., Ma, B., Hernandez, N. (July 1999) SNAP(c): a core promoter factor with a built-in DNA-binding damper that is ... to the core promoter through protein-protein contacts with the POU domain of the enhancer-binding factor Oct-1. We show that a ... This may represent a general mechanism to ensure that core promoter-binding factors, which have strikingly slow off-rates, are ...
AML - C-kit Mutation, Core binding factor 4 Replies Thu, Mar 03, 2022 ... Risk factors. Factors that may increase the risk of Wilms tumor include:. *African-American race. In the United States, ... If your child has risk factors for Wilms tumor (such as known associated syndromes), the doctor may recommend periodic kidney ...
res ,- BaalChIP(samplesheet=samplesheet, hets=hets) res ,- BaalChIP.run(res, cores=4, verbose=TRUE) #cores for parallel ... BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes. \ Ines de Santiago, Wei Liu, Ke ... BaalChIP is a rigorous statistical method to identify allele-specific binding of transcription factors, which is important, for ... cores=4, verbose=TRUE) #cores for parallel computing. Note that the example data in this vignette does not reveal real biology ...
Insulin-like growth factor-binding proteins and bone metabolism.. Conover CA., Am J Physiol Endocrinol Metab 294(1), 2008 PMID ... Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis.. Beattie J, Allan GJ, Lochrie JD, ... Insulin-like growth factor binding protein-5 in osteogenesis: facilitator or inhibitor?. Mukherjee A, Rotwein P., Growth Horm ... Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A.. ...
Antibodies for proteins involved in positive regulation of sequence-specific DNA binding transcription factor activity pathways ... git-url: [email protected]:thermofisher/magellan-core.git git-branch: origin/release/Cookie_Reduction ...
Prognosis and monitoring of core-binding factor acute myeloid leukemia: Current and emerging factors. Expert Rev Hematol. 8:43- ... Core binding factor abnormalities are associated with an improved outcome in patients with AML (39-41). However, in the present ... Other core binding factor (CBF) abnormalities that are often associated with a good prognosis often lose this association in ... Overall survival time in de novo AML and in t-AML with core binding factor abnormalities. t-AML, therapy-related acute myleoid ...
... anti-sigma factor binding domain. *. Domain d1h3lb_: 1h3l B: [76640]. truncated sigma2 domain core; anti-sigma factor binding ... Timeline for Protein Sigma factor SigR from a.177.1.1: Sigma2 domain of RNA polymerase sigma factors: *Protein Sigma factor ... Protein Sigma factor SigR from a.177.1.1: Sigma2 domain of RNA polymerase sigma factors appears in SCOPe 2.05. *Protein Sigma ... Protein Sigma factor SigR from a.177.1.1: Sigma2 domain of RNA polymerase sigma factors appears in the current release, SCOPe ...
Core of Sph element; Core motif of Sph element in maize C1 gene to which maize VP1 (viviparous 1) protein binds; VP1-responsive ... RAV1-A binding site motif; RAV1AAT. Binding consensus sequence of Arabidopsis transcription factor, RAV1; RAV1 specifically ... Core of consensus maize P (myb homolog) binding site; 6 bp core; Maize P gene specifies red pigmentation of kernel pericarp, ... Binding sites with simlar sequences. Binding site. Motif_356. Name. S2FSORPL21. Description. S2F binding site (S2 site) in ...
Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor ... enables RNA polymerase I core binding IBA Inferred from Biological aspect of Ancestor. more info ... RRN3 RNA polymerase I transcription factor homolog pseudogene. *RRN3 homolog, RNA polymerase I transcription factor pseudogene ... enables RNA polymerase I general transcription initiation factor activity IBA Inferred from Biological aspect of Ancestor. more ...
Diagnosis of a core binding factor leukemia (t(8;21), t(16;16) or inv(16)). Diagnosis of acute promyelocytic leukemia (t(15;17 ... Core binding factor acute myeloid leukemia MedlinePlus related topics: Acute Myeloid Leukemia Leukemia Myelodysplastic ...
Rabbit polyclonal TATA binding protein TBP antibody - Nuclear Loading Control and ChIP Grade. Validated in WB, IP, IHC, ChIP, ... General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the ... Recombinant Human TATA binding protein TBP (ab81897) at 0.1 µg. Lane 2 : Recombinant Human TATA binding protein TBP (ab81897) ... Anti-TATA binding protein TBP antibody - Nuclear Loading Control and ChIP Grade. See all TATA binding protein TBP primary ...
Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter.. Blood. 2021 May 19. pii: 475975. doi: 10.1182/blood ... Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies.. Blood. ... Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report.. ... Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity.. Blood. ...
Since transcription factors generally do not tolerate insertions/deletions in the core binding site, PWM models are usually ... Each DNA-binding domain of the subclass of nuclear hormone receptors binds to the consensus sequence AGGTCA. Specificity in ... subunit pairings define the spacing and orientation of the factors and thereby the binding sites. Standard bioinformatics ... NRs are unique in that they serve both as receptors for hormones or steroids and as TFs via a DNA binding domain resembling ...
... both of which depend on the binding of proteins, such as the CCCTC binding factor (CTCF), to form DNA-CTCF complexes (Figure 1 ... Smale, S.T.; Kadonaga, J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 2006, 72, 449-479. [Google Scholar] [ ... Transcription Factor-Binding Sites at Gene Promoters. A promoter is a DNA region between 20 and 1000 bp upstream of the ... Spitz, F.; Furlong, E.E. Transcription factors: From enhancer binding to developmental control. Nat. Rev. Genet. 2012, 13, 613- ...
HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically ... Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G. Harjes, S., Solomon, W. C., ... The restriction factors of human immunodeficiency virus. Harris, R. S., Hultquist, J. F. & Evans, D. T., Nov 30 2012, In: ... A comparison of two single-stranded DNA binding models by mutational analysis of APOBEC3G. Shindo, K., Li, M., Gross, P. J., ...
JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six ... The JASPAR CORE database contains a curated, non-redundant set of profiles, derived from published collections of ... The high-quality transcription factor binding profile database. Read more about JASPAR. JASPAR interactive tour ... JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position ...
29] The death domain of tumor necrosis factor 1 and the cytoplasmic tail of lymphotoxin beta bind to the core protein. Nuclear ... factor kappa B (NF-kB) is activated in core peptide-transfected hepatoma cells and in HCV-infected liver tissue. NF-kB ... Another major risk factor for HCV is high-risk sexual behavior. The incidence of acute HCV infection has sharply decreased in ... IgM antigen was the core protein, suggesting cross-reactivity to IgG. [21] Co-affinity of IgM anticore antibody to IgG may be a ...
This work was supported in part by the Chemical Biology Core; the Participant Research, Interventions, and Measurement Core; ... We thank Ligia Pinto for the methods to measure IgG responses against the receptor-binding domain and spike proteins of SARS- ... We noted factors independently associated with testing positive for SARS-CoV-2 antibodies (Table 1). Potential exposure to a ... Factors related to social distancing (e.g., essential worker status, not practicing social distancing, contact with a virus- ...
Predicted to be part of core TFIIH complex portion of holo TFIIH complex; transcription factor TFIID complex; and transcription ... Predicted to enable RNA polymerase II general transcription initiation factor activity and protein N-terminus binding activity ... general transcription factor IIH, polypeptide 3. MGI:1277143 Go Annotations as Summary Text (Tabular View) (GO Graph). ... Orthologous to human GTF2H3 (general transcription factor IIH subunit 3).. Go Annotations in Tabular Form (Text View) (GO Graph ...
Template activating factor-I (TAF-I) is a histone-binding chromatin remodeling factor. We recently found that TAF-I is capable ... Here we present evidence that TAF-I preferentially binds to histone H3 among four core histones. Immunofluorescent staining ... Histone- and chromatin-binding activity of template activating factor-I. Matsumoto K , Nagata K , Okuwaki M , Tsujimoto M . ... revealed that TAF-I binds to the decondensed sperm chromatin, of which protein components predominantly consist of histones H3 ...
... and shows partial homology to the receptor binding domain of tumor necrosis factor alpha. DENN is virtually identical to MADD, ... Human C-MYC promoter-binding protein IRLB This entry represents the core or cDENN domain. ... In addition to the ISRE-binding domain IRLB contains a tripartite DENN domain, a nuclear localization signal, two PPRs, and a ... IRLB was originally identified as a partial cDNA clone, encoding a 191-aa protein binding the interferon-stimulated response ...
  • The structure of the MEF2S domain is entirely different from that of the equivalent SAM domain in SRF and MCM1, accounting for the absence of cross-reactivity with other proteins that interact with these transcription factors. (rcsb.org)
  • This binding turns on (activates) the KIT protein, which then activates other proteins inside the cell by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. (medlineplus.gov)
  • Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice. (nature.com)
  • NRs are unique in that they serve both as receptors for hormones or steroids and as TFs via a DNA binding domain resembling those present in C2H2 zinc finger proteins. (iscb.org)
  • Unlike C2H2 proteins, DNA binding by NRs requires dimerization of subunits. (iscb.org)
  • Many DNA-binding proteins show co-localization in ChIP-Seq data without presence of the corresponding DNA motifs. (sdbonline.org)
  • (A) LDs are composed by a neutral core of triacylglycerols (TAGs) and sterol esters (SEs), surrounded by a monolayer of phospholipids and unesterified sterol, with several proteins at the surface and/or partially integrated within their structure, mainly from the PAT family: perilipin 1 (PLIN1), perilipin 2 (PLIN2), and perilipin 3 (PLIN3). (frontiersin.org)
  • A number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins), specifically bind the DNA sequence (A/T)GATA(A/G) [ ( PUBMED:2249770 ) ] in the regulatory regions of genes. (embl-heidelberg.de)
  • RNA processing mediated by RNA-binding proteins (RBPs) encompasses many steps in the life of an RNA including pre-mRNA splicing, termination and polyadenylation, nonsense mediated decay (NMD) and mRNA export, with potential to significantly modify the gene expression output at each step. (elifesciences.org)
  • The SR proteins comprise a family of essential, structurally related RNA binding proteins. (biomedcentral.com)
  • Here we use iCLIP to globally analyze and compare the RNA binding properties of two SR proteins, SRSF3 and SRSF4, in murine cells. (biomedcentral.com)
  • Surprisingly, both SR proteins bound to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism. (biomedcentral.com)
  • In contrast, SRSF3 but not SRSF4 specifically bound transcripts encoding numerous RNA binding proteins. (biomedcentral.com)
  • While investigation of transcriptional regulation by transcription factors has led to a deep understanding of how DNA binding proteins direct RNA polymerases to genes, regulation of RNA processing by RNA-binding proteins is still enigmatic. (biomedcentral.com)
  • Hundreds of proteins encoded by metazoan genomes have RNA-binding capacity conferred by specific protein structural domains, such as RNA recognition motifs (RRMs), KH domains and zinc fingers [ 1 ]. (biomedcentral.com)
  • RNA-binding proteins can change gene expression output at different steps of RNA metabolism, including pre-mRNA splicing, polyadenylation, RNA export, RNA stability, and translation. (biomedcentral.com)
  • However, the in vivo binding specificity and function(s) of most RNA-binding proteins are not well understood. (biomedcentral.com)
  • However, the latter analysis provided information at the gene level and did not identify direct binding sites of SR proteins to RNA targets. (biomedcentral.com)
  • The development of ultraviolet (UV) crosslinking and immunoprecipitation (CLIP) followed by high-throughput sequencing has made possible the identification of in vivo binding sites of RNA-binding proteins in a genome-wide manner [ 14 ]. (biomedcentral.com)
  • Forkhead box O (FoxO) transcription factors are conserved proteins involved in the regulation of life span and age-related diseases, such as diabetes and cancer. (jbc.org)
  • Stress stimuli or growth factor deprivation promotes nuclear localization and activation of FoxO proteins, which-depending on the cellular context-can lead to cell cycle arrest or apoptosis. (jbc.org)
  • We observed that, like Sc WhiD and other Wbl proteins, Sv WhiD binds a [4Fe-4S] cluster that is moderately sensitive to O 2 and highly sensitive to nitric oxide (NO). (jbc.org)
  • When appropriately stimulated by growth factors such as bone morphogenic proteins, which are members of the TGF-β superfamily, they undergo cell division and produce offspring that differentiate into osteoblasts . (humpath.com)
  • Osteoblasts express cell-surface receptors that bind many hormones (parathyroid hormone [PTH], vitamin D, and estrogen), cytokines, growth factors, and extracellular matrix proteins. (humpath.com)
  • The proteins encoded by Myb genes bind to DNA and regulate the expression of other genes that control cell division, differentiation, and cell death. (stanford.edu)
  • The Myb proteins interact with a highly conserved multi-protein complex called the MuvB core. (stanford.edu)
  • The same complex also interacts with proteins of the Rb tumor suppressor family and the E2F transcription factor family. (stanford.edu)
  • In particular, we are studying deregulation of transcription factors C/EBPα and core-binding factors, CBFs (consisting of RUNX and CBFβ proteins) in AML. (versiti.org)
  • By binding to different proteins, lncRNAs and their associated proteins control different cancer processes and regulate different genes relevant to cancer progression. (dana-farber.org)
  • To accelerate our understanding of which proteins bind to which RNAs and how these might be targeted for therapy, we have developed a high-throughput platform that allows us to systematically test every protein in the human proteome against any RNA of interest. (dana-farber.org)
  • In the smallest repeating unit of the packaged genetic material, or chromatin, ~150 DNA base pairs wrap around a core of histone proteins, forming the nucleosome. (harvard.edu)
  • We made a recent discovery that when injected into the bloodstream adenovirus serotype 5 becomes coated in one of our own proteins in the blood called a coagulation factor. (ukri.org)
  • Two of these genes, RUNX1 and CBFB , provide instructions for making the two pieces of a protein complex known as core binding factor (CBF). (medlineplus.gov)
  • The fusion protein can form CBF, but it is thought that the presence of the MYH11 portion of the fusion protein prevents CBF from binding to DNA, impairing its ability to control gene activity. (medlineplus.gov)
  • The KIT protein is found in the cell membrane of certain cell types where a specific protein, called stem cell factor, attaches (binds) to it. (medlineplus.gov)
  • KIT gene mutations associated with GISTs create a protein that no longer requires binding of the stem cell factor protein to be activated. (medlineplus.gov)
  • snRNA gene transcription is activated in part by recruitment of SNAP(c) to the core promoter through protein-protein contacts with the POU domain of the enhancer-binding factor Oct-1. (cshl.edu)
  • IGF binding protein-5 (BP-5) is an important bone formation regulator. (uni-bielefeld.de)
  • Therefore, elucidation of the identity of IGF binding protein-5 (BP-5) protease produced by osteoblasts is important for our understanding of the molecular pathways that control the action of BP-5. (uni-bielefeld.de)
  • ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts", BIOCHEMISTRY , vol. 41, 2002, pp. 15394-15403. (uni-bielefeld.de)
  • Immunofluorescent staining revealed that TAF-I binds to the decondensed sperm chromatin, of which protein components predominantly consist of histones H3 and H4. (xenbase.org)
  • DENN/MADD is a component of a signalling protein complex that is localized to the cytosol and exerts multiple functions by using different binding partners. (embl.de)
  • Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges small star, filled. (embl.de)
  • IRLB was originally identified as a partial cDNA clone, encoding a 191-aa protein binding the interferon-stimulated response element (ISRE) in the P2 promoter of human MYC. (embl.de)
  • The proposed mechanism of ATRA action involves binding of ATRA to the fusion protein promyelocytic leukemia (PML)/retinoic acid receptor α (RARα) that is encoded by a translocation involving PML gene on chromosome 15 and RARA gene on chromosome 17, and which is assumed to act as a co-repressor. (biomedcentral.com)
  • The core offers support for a variety of interaction studies based of protein enrichment/precipitation on an affinity matrix. (bcm.edu)
  • protein-DNA interactions where DNA is used as a bait for protein binding (catTFRE transcription factor profiling, promoter pulldowns, response element pulldowns), 3. (bcm.edu)
  • The core offers options for antibody/affinity characterization, optimization of protein extraction, and cellular pre-fractionation in cases where interacting partners are sought for specific cellular compartments (e.g. nuclear or cytosolic). (bcm.edu)
  • The protein is activated by stress factors that can compromise the genomic integrity of the cell. (proteopedia.org)
  • These different pathways correspond, at least in part, to differences in p53-DNA binding affinity and stability, which are determined by specific protein-DNA interactions. (proteopedia.org)
  • The p53 protein consists of the N-terminal transactivation domain, the DNA binding domain ( DBD ) or core, the tetramerization domain ( see its structure below ), and the C-terminal regulatory domain ( Figure 3 ). (proteopedia.org)
  • The HCV core protein and DENV capsid protein, extensively interact with LDs to regulate their replication and assembly. (frontiersin.org)
  • The complex resembles a hand holding a rope with the palm and fingers representing the protein core and the thumb, the carboxyl-terminal tail. (embl-heidelberg.de)
  • In the absence of SRSF3 binding, Nanog mRNA is sequestered in the nucleus and protein levels are severely downregulated. (elifesciences.org)
  • SRSF3 (serine-arginine-rich splicing factor 3) belongs to the family of SR protein splicing factors. (elifesciences.org)
  • Crystal Structure of a Core Spliceosomal Protein Interface. (ualberta.ca)
  • They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
  • It contains a number of ubiquitous and erythroid specific protein binding sites, including the previously described factors NF-E1 (GF1) and NF-E2. (eur.nl)
  • This gene encodes the core binding factor A protein that controls the differentiation and growth of osteoblast precursor cells, which are essential for endochondral and intramembranous ossification. (jco-online.com)
  • These changes should be consistent with a deficiency in TGF-β1 signaling, a pleiotropic factor that controls ECM homeostasis by down-regulating MMP expression and inducing ECM protein components. (edu.au)
  • 6] Mutation of CEBPA (the gene encoding CCAAT/enhancer binding protein alpha, a granulocytic differentiation factor and member of the bZIP family) was described in a family with 3 members affected by AML. (medscape.com)
  • RNA-binding protein;RNA degradosome binding protein [Ensembl]. (ntu.edu.sg)
  • IMSEAR at SEARO: The usefulness of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) for evaluation of children with short stature. (who.int)
  • Jaruratanasirikul S, Leethanaporn K, Sriplung H. The usefulness of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) for evaluation of children with short stature. (who.int)
  • The diagnostic value of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) was studied in 24 growth hormone deficient (GHD) and 36 normal variant short stature (NVSS) children. (who.int)
  • A DNA-binding protein that contains an N-terminal BTB (POZ) DOMAIN and C-terminal CYS2-HIS2 ZINC FINGERS . (nih.gov)
  • The inhibitory effect of resveratrol on poxviruses is independent of VACV N1 protein, a potential resveratrol binding target. (researchgate.net)
  • The coagulation factor 'sticks' to a specific protein on the coat of the virus called the hexon. (ukri.org)
  • The major Ad5: host interaction is with coagulation factor X which binds Ad5 hexon protein hypervariable regions (HVRs) leading to liver transduction following intravascular delivery. (ukri.org)
  • Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. (parisepigenetics.com)
  • Loss of the methyl-CpG binding protein ZBTB4 alters the mitotic checkpoint, increases aneuploidy, and promotes tumorigenesis", Cancer Research, 2016 Nov 4. (parisepigenetics.com)
  • MOCA was initially identified as a protein that binds to presenilin, a molecule that when mutated causes familial Alzheimer's disease. (salk.edu)
  • Nuclear receptors (NR) are transcription factors (TF) responsible for the regulated expression of genes active in diverse biological processes, such as metabolism, detoxification and cellular differentiation. (iscb.org)
  • Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. (embl-heidelberg.de)
  • In a genome-wide investigation, we found that the number of transcription factor binding sites (TFBSs) in de novo genes of S . cerevisiae increased rapidly and quickly became comparable to the number of TFBSs in established genes. (biomedcentral.com)
  • Almost half of these genes are associated with either GAGA factor (GAF) or a newly discovered factor we call M1BP. (elsevier.com)
  • Binding of the transcription factor nuclear factor E2-related factor 2 (Nrf2) to the antioxidant response element (ARE) in neural cells results in the induction of a battery of genes that can coordinate a protective response against a variety of oxidative stressors. (jneurosci.org)
  • SRSF3 and SRSF4 binding sites mapped to largely non-overlapping target genes, and in vivo consensus binding motifs were distinct. (biomedcentral.com)
  • Integration of chromatin accessibility (ATACseq) and expression data (RNAseq) revealed a core desiccation response across these two grasses including many genes with binding sites for the core seed development transcription factor ABI5. (biorxiv.org)
  • Ubiquitination-triggered proteasomal degradation of DNA-bound NF-ĸB strongly limits the expression of its target genes. (jbc.org)
  • PTFs also enable other transcription factors, histone modifiers, and nucleosome remodeling complexes to alter the chromatin state and promote gene expression of silenced genes. (cytoskeleton.com)
  • The transcription factors Oct4, Sox2, and Klf4 were found to trigger endogenous expression of pluripotent genes [2] and were identified as PTFs due to their ability to access closed chromatin [3] . (cytoskeleton.com)
  • In this study, we identified pronounced anti-correlated transcriptional and methylation gradients including a core of 271 genes controlling zonated metabolic and morphogen networks and observed a prominent porto-central gradient of DNA methylation at 46 transcription factor binding sites. (uniklinikum-dresden.de)
  • Our bioinformatics analyses indicate that the major role of these factors in the conversion is the down-regulation of developmental genes in partial iPSCs. (refine.bio)
  • In this view, module member genes, motifs, and regulatory influences are represented as peripheral nodes connected to core module node via edges. (systemsbiology.net)
  • Interestingly, the coated virus then only delivers genes to the liver via the interaction with the coagulation factor and not a direct interaction between the liver and the viru (i.e. the coagulation factor acts as a bridge between the cell and the virus). (ukri.org)
  • 1999), Histone- and chromatin-binding activity of temp. (xenbase.org)
  • Histone- and chromatin-binding activity of template activating factor-I. (xenbase.org)
  • Template activating factor-I ( TAF-I ) is a histone-binding chromatin remodeling factor. (xenbase.org)
  • Background: Super-enhancers are clusters of transcriptional enhancers densely occupied by the Mediators, transcription factors and chromatin regulators. (researchgate.net)
  • Specifically, super-enhancers are clusters of enhancers defined based on the binding occupancy of master transcription factors, chromatin regulat. (researchgate.net)
  • Moreover, SRSF3 controls the alternative splicing of the export factor Nxf1 and RNA regulators with established roles in pluripotency, and the steady-state levels of mRNAs encoding chromatin modifiers. (elifesciences.org)
  • In this closed state, chromatin structure becomes an obstacle for eukaryotic transcription by impeding the interaction of RNA polymerase machinery and most transcription factors (TFs). (cytoskeleton.com)
  • This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)
  • However, our understanding of chromatin structure and how transcription factors regulate higher-order genome architecture is limited. (versiti.org)
  • We are exploring the mechanisms by which transcription factors regulate chromatin dynamics in normal and malignant HSCs, and the implications of chromosomal rearrangements observed in hematological malignancies in topologically associated domains (TAD) architecture and gene expression. (versiti.org)
  • This will allow individual mechanistic contributions of chromatin organizing factors and their effectors to be explicitly defined. (hhs.gov)
  • In particular, how ATP-dependent chromatin remodeler complexes recognize DNA features and sequence-specific organizing factors, will be addressed. (hhs.gov)
  • Biochemical reconstitution will be used to tease apart selected individual contributions of chromatin organization and activator/repressor binding towards assembly of the transcription machinery on a genomic scale. (hhs.gov)
  • Chromatin is generally thought to be composed of nucleosome particles containing 2 copies of each of the four core histones. (hhs.gov)
  • Specificity in binding site selection (and responses) is achieved using different dimerization modes subunit pairings define the spacing and orientation of the factors and thereby the binding sites. (iscb.org)
  • contributes most to binding specificity. (proteopedia.org)
  • PRV-300 (previously known as JNJ-42915925) is a first-in-class, fully human, IgG4κ monoclonal antibody (mAb) that binds the extracellular domain of TLR3 with high specificity and affinity. (proventionbio.com)
  • Core binding factor acute myeloid leukaemia and c-KIT mutations. (cdc.gov)
  • Here we present evidence that TAF-I preferentially binds to histone H3 among four core histones. (xenbase.org)
  • Below we discuss mechanisms in the form of pioneer transcription factors, histone modifications, and recently identified actin-dependent mechanisms that regulate chromosome accessibility and gene regulation during cellular reprogramming. (cytoskeleton.com)
  • Remodelers are multi-subunit complexes characterized by a conserved core ATPase responsible for breaking histone-DNA contacts. (harvard.edu)
  • Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). (jax.org)
  • The body breaks down the prodrug to produce a signaling molecule that is biased toward binding to and activating CD122, a subunit of IL-2R. (secunderabadchronicle.in)
  • A proposed mechanism, based on the extrusion of DNA by cohesin, suggests that the DNA-binding motif of CTCF and its orientation determine the start and end of the loop. (sdbonline.org)
  • Motif calling was performed at boundaries, validating the presence of known insulators, along with M1BP motif, which recently has also been shown to be associated to boundaries and core promoter motif 6 and motif 8, which have not been associated to boundaries before. (sdbonline.org)
  • A comprehensive set of core promoter motifs are detected at boundaries, including the newly discovered M1BP motif, and motifs which have been associated to housekeeping gene expression. (sdbonline.org)
  • Figure 5: p53 binding site motif with G/C base pairs most conserved. (proteopedia.org)
  • M1BP binds a core promoter element called Motif 1. (elsevier.com)
  • In the proposed "zinc finger" DNA-binding motif, each repeat unit binds a zinc metal ion through invariant Cys and His residues and this drives the folding of each 30-residue unit into an independent nucleic acid-binding domain. (embl.de)
  • The Core binding factor (CBF) is a group of heterodimeric transcription factors. (wikipedia.org)
  • Hypoxia-inducible factors are heterodimeric transcription factors that play a crucial role in a cell's ability to adapt to low oxygen. (jbc.org)
  • Can your current system move up to a faster chip like a Core i5 or i7 processor? (eurogamer.net)
  • Or we can push on and upgrade with a more capable Core i7 processor. (eurogamer.net)
  • We will conduct practical experiments using a ready-made assembly from the ARTLINE company, based on the flagship 16-core Ryzen 9 7950X processor complete with a GeForce RTX 3090 24 GB video card. (mezha.media)
  • The cost of the new CPUs varies from $299 for a 6-core 12-thread chip to $699 for a flagship 16-core processor. (mezha.media)
  • Each DNA-binding domain of the subclass of nuclear hormone receptors binds to the consensus sequence AGGTCA. (iscb.org)
  • We propose that the lack of core fucosylation of TGF-β1 receptors is crucial for a developmental and progressive/destructive emphysema, suggesting that perturbation of this function could underlie certain cases of human emphysema. (edu.au)
  • Cannabis cannabinoids interact with and bind to brain receptors. (sukury.com)
  • It binds specifically to GABA A receptors to enhance their inhibitory effects. (medscape.com)
  • The N-terminal part, which includes the helix, is similar in structure, but not sequence, to the N-terminal zinc module of the glucocorticoid receptor DNA-binding domain. (embl-heidelberg.de)
  • Finally, Molecular docking and molecular dynamics simulations were used to screen the active ingredients of JGSQP acting on PDE-5, and analyze the ligand-receptor interaction relationship and binding free energy. (lww.com)
  • METHODS: Genetically modified mouse models of Cdc42, dopamine receptor D1 (D1R) and D2 (D2R) and expressed Cdc42 point mutants that are defective in binding to and activation of its downstream effector molecules PAK and N-WASP were generated, respectively, in CA1 or dentate gyrus (DG) subregion. (bvsalud.org)
  • The receptor family includes four distinct members, including epidermal growth factor receptor (EGFR or ErbB1), HER2 (ErbB2 or p185 neu ), HER3 (ErbB3) and HER4 (ErbB4 or tyro2). (justia.com)
  • In fact, Fut8 -/- mice have a marked dysregulation of TGF-β1 receptor activation and signaling, as assessed by TGF-β1 binding assays and Smad2 phosphorylation analysis. (edu.au)
  • In this paper, researchers used an experimental drug to prevent CRF from binding to the brain receptor called CRFR1 in mice with Alzheimer's that were free from memory impairments, therefore blocking its effects. (alz.org)
  • Moreover, they found that interrupting the hormone from binding to the CRFR1 receptor blocked the improvement of memory normally promoted by exercise. (alz.org)
  • Corticotropin-Releasing Factor Receptor 1 Activation During Exposure to Novelty Stress Protects Against Alzheimer's Disease-Like Cognitive Decline in AßPP/PS1 Mice , Journal of Alzheimer's Disease. (alz.org)
  • Here we show that NMN treatment partially reverses the effects of tumor necrosis factor-alpha (TNF-α) on human primary osteoblasts (HOBs): senescent cell induction, diminished osteogenic differentiation ability and intracellular NAD + and NADH levels. (qualitycounts.com)
  • The process of osteoblastic differentiation is initiated and governed by the transcription factor core binding factor a1, which activates osteoblast-specific gene expression . (humpath.com)
  • For this purpose, we proceed various research, such as DNA demethylation-promoting transcription factors and their role, mechanism of disease onset induced by abnormality of DNA methylation regulatory factors, epithelial-to-mesenchymal transition (EMT) process and its related disease, and mechanism of germ cell differentiation. (riken.jp)
  • Master Transcription Factors Regulate the DNA Methylation Landscape During Hepatocyte Differentiation. (riken.jp)
  • Emphasis is placed on the trans-acting transcriptional regulators that bind to cis-elements within the core and upstream regulatory regions of Prm1 under basal conditions and in response to cellular differentiation. (urotoday.com)
  • Key control points for this differentiation in B-cells, or other immune cells, are transcription factors. (drugtargetreview.com)
  • Differentiation heat": the original mix of Earth was likely relatively even, but heavy elements would tend to sink towards the core while lighter would float up towards the upper mantle. (newbedev.com)
  • The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. (iospress.com)
  • Cnot1 and Cnot3 and Trim28 which is known to extensively share genomic binding sites with Cnot3 contribute to this conversion as well. (refine.bio)
  • DNA-binding activity of hypoxia-inducible factors (HIFs). (uzh.ch)
  • The solution structure of the 33 kDa complex between the dimeric DNA-binding core domain of the transcription factor MEF2A (residues 1-85) and a 20mer DNA oligonucleotide comprising the consensus sequence CTA(A/T)(4)TAG has been solved by NMR. (rcsb.org)
  • This may represent a general mechanism to ensure that core promoter-binding factors, which have strikingly slow off-rates, are recruited specifically to promoter sequences rather than to cryptic-binding sites in the genome. (cshl.edu)
  • Strikingly, SRSF3 binds to the core pluripotency transcription factor Nanog mRNA to facilitate its nucleo-cytoplasmic export independent of splicing. (elifesciences.org)
  • Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)
  • Transcription factor binding motifs help to elucidate regulatory mechanism. (systemsbiology.net)
  • Znf domains are often found in clusters, where fingers can have different binding specificities. (embl.de)
  • We estimated SARS-CoV-2 seroprevalence among residents of Hillsborough County, Florida, USA, to determine factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
  • The goals of this study were to estimate SARS-CoV-2 seroprevalence among Hillsborough County residents and to determine the demographic and behavioral factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
  • In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. (cellsignal.com)
  • in situations where an antibody will be used to support large, long-term studies, this can be an especially critical factor. (cellsignal.com)
  • Particle-enhanced assays are based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)
  • Scientists have detailed the role of a key controlling factor in the transformation of B-cells into antibody-secreting cells. (drugtargetreview.com)
  • Therefore, the researchers say that T-bet is not a core transcription factor required for antibody-secreting cell commitment in all settings. (drugtargetreview.com)
  • drug/small molecule target identification (binding to drug-bead conjugates), and 4. (bcm.edu)
  • For the quantification of CRP, particles consisting of a polystyrene core and a hydrophilic shell are used in order to link anti-CRP antibodies covalently. (cdc.gov)
  • The B lymphocyte produces antibodies, which bind to viruses and bacteria and target those pathogens for elimination. (drugtargetreview.com)
  • Thus, SNAP(c) represses its own binding to DNA, and repression is relieved by interactions with the Oct-1 POU domain that promote cooperative binding. (cshl.edu)
  • This entry represents the core or cDENN domain. (embl.de)
  • N-ter=N-terminal, DBD=DNA binding domain [1] , Tet=Tetramerization [2] , and C-ter=C-terminal domain. (proteopedia.org)
  • Such mutations are predominantly located in the p53-DNA binding domain ( DBD ),based on an analysis of human tumors ( Figure 3 ). (proteopedia.org)
  • NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. (embl-heidelberg.de)
  • The three-dimensional solution structure of a complex between the DNA binding domain of the chicken erythroid transcription factor GATA-1 and its cognate DNA site has been determined with multidimensional heteronuclear magnetic resonance spectroscopy. (embl-heidelberg.de)
  • The DNA binding domain consists of a core which contains a zinc coordinated by four cysteines and a carboxyl-terminal tail. (embl-heidelberg.de)
  • FGF18 is a binding growth factor with a core 120 amino acid FGF domain which allows for a common tertiary structure. (prospecbio.com)
  • Structural elucidation of a PRP8 core domain from the heart of the spliceosome. (ualberta.ca)
  • Gain-of-function mutations in the second intracellular kinase domain (TK2) and in the juxtamembrane domain are described in patients with core binding factor acute myeloid leukemia (CBFL) and are associated with leukocytosis. (haematologica.org)
  • S1 RNA binding domain, Ribonuclease E/G family, Polyribonucleotide phosphorylase C terminal [Interproscan]. (ntu.edu.sg)
  • There are many factors that assess your website or blog such as Domain factors, Page level factors, Site level factors, backlinks, user interaction, special algorithm rules and many others. (promoteabhi.com)
  • To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)
  • The polymerase component, which contains a conserved C-terminal structural loop, preferentially binds to and fills-in short gapped DNA intermediates with RNA and LigC ligates the resulting nicks to complete repair. (genengnews.com)
  • Until the end of 2014, it used to be common wisdom that a premium on Asia-bound cargos was a long-term structural feature of the global LNG market. (ispionline.it)
  • Oil price may well quickly recover in the next few years, but a second factor is bound to influence price dynamics in the Asian Basin (and beyond): structural oversupply. (ispionline.it)
  • The first factor is that the Hyperlibrary's intrinsic collaborative developmental approach introduces a powerful combination of flexibility, adaptability, and applicability that is capable of addressing a range of different classes. (divched.org)
  • The DBD in tetrameric form binds to a DNA response element , which consists of two DNA half sites. (proteopedia.org)
  • 1. Elucidate the cellular mechanism of tetramer assembly, i.e., monomer conversion, through the study of soluble and membrane bound forms of physiological αSyn and determine how tetrameric αSyn is compromised by factors associated with increased risk for synucleinopathies in model systems and human tissue with a special emphasis on the involvement of lipids. (ucl.ac.uk)
  • Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. (medlineplus.gov)
  • and core binding factor leukemia, a rare blood and bone marrow cancer. (addiandcassi.com)
  • The Kasumi-1 cell line is an intensively investigated model system of Acute Myeloid Leukemia with t(8;21) translocation, that represents 1 of the 2 main subtypes of Core Binding Factor Leukemia (CBFL). (elsevier.com)
  • High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia. (atlasgeneticsoncology.org)
  • Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter. (versiti.org)
  • Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. (nih.gov)
  • Although both factors dictate the association of Pol II at their target promoters, they are nearly mutually exclusive on the genome and mediate different mechanisms of regulation. (elsevier.com)
  • The results showed that there were 212 potential targets of JGSQP for ED disease, and GO analysis revealed that the main pathways were positive regulation of DNA-binding transcription factor activity, regulation of vascular diameter, and negative regulation of vascular diameter, etc. (lww.com)
  • Focusing on TPα, this review details the current understanding of the factors regulating its expression and transcriptional regulation through Prm1, including in prostate and breast cancers. (urotoday.com)
  • Collectively, this review details current knowledge of the factors determining regulation of the TXA2-TPα axis and thereby provides a genetic basis for understanding the role of TXA2 in the progression of certain human cancers. (urotoday.com)
  • We establish serine-arginine-rich splicing factor 3 (SRSF3) as an essential regulator of RNAs encoding key components of the mouse pluripotency circuitry, SRSF3 ablation resulting in the loss of pluripotency and its overexpression enhancing reprogramming. (elifesciences.org)
  • Furthermore, recent publications imply membranous compartments as the nucleation cores of Lewy bodies and that lipid binding is necessary for pathological oligomers to exert toxicity, showing that the α Syn -lipid interaction is central for both its physiology and pathomechanism. (ucl.ac.uk)
  • However, a better understanding of the biophysical properties of the nucleosome and the factors that regulate them has made it clear over the last decade that the nucleosome is intrinsically dynamic. (harvard.edu)
  • A single zinc finger can exist as an independent structure sufficient for zinc-dependent DNA binding. (embl.de)
  • We also showed that although C. elegans (nematode worm) lost its animal-type Myb gene hundreds of millions of years ago, the Drosophila Myb "key" still binds to and can open the highly conserved worm MuvB "lock" that represses gene expression. (stanford.edu)
  • The authors also characterized a SWR1-nucleosome co-complex, revealing a significant conformational change involving the catalytic ATPase and the H2A.Z/H2B-binding module. (harvard.edu)
  • Standard bioinformatics methods for the detection of TF binding sites are based on profile models, termed Position Weight Matrices (PWMs). (iscb.org)
  • However, in the specific case of NRs, PWMs are clearly insufficient to describe the observed properties of binding sites. (iscb.org)
  • We have constructed a framework for describing NR binding preferences as 1-state Hidden Markov Models, enabling simultaneous prediction and classification of NR binding sites. (iscb.org)
  • The JASPAR CORE database contains a curated, non-redundant set of profiles, derived from published collections of experimentally defined transcription factor binding sites for eukaryotes. (genereg.net)
  • The p53 consensus site ( Figure 2 ) is formed by two decameric half-sites, each containing a core element (red), that are separated by a variable number of base pairs (blue). (proteopedia.org)
  • We therefore conclude that a combination of factor binding sites is necessary to allow site 3 to function as a strong transcriptional activator, resulting in position independent expression of the beta-globin gene. (eur.nl)
  • we show that the LigC complex interacts with core BER [base excision repair] enzymes in vivo and demonstrate that together these factors constitute an excision repair apparatus capable of repairing damaged bases and abasic sites," the authors wrote. (genengnews.com)
  • No Binding sites available for this model. (genereg.net)
  • We have at least 3,500 textbooks and 45,000* other items in a variety of locations (both in the library and in a multitude of sub-sites within this building and others), so our focus has been on getting the core textbooks onto the system. (dumplinginahanky.com)
  • Thus, it is possible that additional factors are involved in the formation of TADs (Ramirez, 2018). (sdbonline.org)
  • This is possible due to cross-linking artifacts and indirect binding, which is, in fact, aggravated at boundaries, which tend to contact each other in 3D space (Ramirez, 2018). (sdbonline.org)
  • In the 2018 release of JASPAR, the CORE collection has been expanded with 322 new PFMs. (researchgate.net)
  • Functional analyses of HBV clones generated by in vitro mutagenesis and cassette exchange showed that the 11 bp insertion is a strong binding site for hepatocyte nuclear factor 1 (HNF-1). (pasteur.fr)
  • Immunohistochemical analyses revealed high levels of cytoplasmic and nuclear hepatitis B core antigen (HBcAg) and only scattered hepatitis B surface antigen (HBsAg) expression in the liver. (pasteur.fr)
  • Your core modules will cover topics like particle physics, nuclear physics and semiconductor technologies. (sheffield.ac.uk)
  • U.S. Showbiz wide algorithms are Found creative download Verification of Arms Reductions: Nuclear, Conventional and Chemical 1989 in factor power for proxy Tracking fields as program, children', region, approximate scan etc. (ghrx.de)
  • Human p53 core complex with DNA (PDB code 3kz8 ). (proteopedia.org)
  • Studies of genetic risk factors of complex disorders, and specifically, genome-wide association studies (GWAS) have been widely employed in the study of complex disorders. (uniklinikum-dresden.de)
  • Our piggyback vector mediated genome-wide screen revealed that Cnot2, one of core components of Ccr4-Not complex participates in this conversion. (refine.bio)
  • In the top versions of the processors, a pair of 8-core CCDs (Core Complex Die) now manufactured by TSMC according to the standards of the most advanced 5 nm technological process are located on the same substrate, as well as a fundamentally new IOD crystal, which is also produced by a Taiwanese company, but already at 6 nm technology. (mezha.media)
  • SRSF3 and SRSF4 display unique RNA binding properties underlying diverse cellular regulatory mechanisms, with shared as well as unique coding and non-coding targets. (biomedcentral.com)
  • Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. (atlasgeneticsoncology.org)
  • We have shown previously that TBP also represses its own binding, and in that case repression is relieved by cooperative interactions with SNAP(c). (cshl.edu)
  • The actual molecular interactions and strength in binding can vary as functions of the sequence and spacer length of the response element. (proteopedia.org)
  • Non-specific interactions - those due to the hard-core repulsion, electrostatic repulsion and/or attraction, weak hydrophobic attraction, van der Waals potentials, etc. (wyatt.com)
  • As described in Interactions Theory , analysis of molar mass as a function of concentration or composition leads directly and intuitively to the determination of binding affinity (usually as the equilibrium dissociation constant, K D ) and absolute molecular stoichiometry . (wyatt.com)
  • We are addressing these issues by structure/function studies involving chemically modified pre-mRNA splicing substrates and splicing factors. (ualberta.ca)
  • while they may lead to the formation of complexes or loosely-bound aggregates, these typically do not exhibit a well-defined stoichiometry or oligomeric state. (wyatt.com)
  • The complete nucleotide sequence of these six variants revealed that five of the six viral genomes, including pF-1, carried a novel 11 base pair (bp) insertion in the core promoter region as well as an 18 bp and an 108 bp in-frame deletion in the pre-S1 region not present in the donor. (pasteur.fr)
  • This observation provides a novel molecular explanation of the importance of Arg248 for p53-DNA binding and its role in cancer. (proteopedia.org)
  • Changes to specific binding behavior and other functionality arising from this 'molecular crowding effect' are poorly understood since most binding studies take place in purified and dilute solutions. (wyatt.com)
  • Mutations in transcription factors have long been shown to be central in tumorigenesis. (versiti.org)
  • Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms. (cdc.gov)
  • JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. (genereg.net)
  • The system's CPU is an x86-64 8-core AMD "Jaguar," and its frequency of 2.1 GHz is slightly higher than the original system. (digitaltrends.com)
  • 4. Larger network capacity: with the help of LoRa's overall innovation and optimization on network capacity (such as node outgoing frequency, packet length, signal quality and node rate, number of available channels, density of base station/gateway, signaling overhead and number of retransmissions), LoRa's communication in the same band is similar to code division multiplexing, and different spread spectrum factors in the same band do not interfere with each other. (iot-rf.com)
  • PPI network analysis revealed that the core targets TGFB1 and EGFR have important roles. (lww.com)