Core binding factor beta subunit. Medical search

A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.

Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.

A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

Myosin type II isoforms found in smooth muscle.

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.

Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. (1/86)

Mice lacking the AML1/PEBP2alphaB/CBFa2 gene or PEBP2beta/CBFb gene exhibit a defect in definitive hematopoiesis and die in utero because of hemorrhage in the central nervous system. Hematopoiesis in the embryo is considered to be tightly associated with vascular development. Here we examined whether PEBP2/CBF plays any role in angiogenesis besides that in definitive hematopoiesis. We found that AML1/PEBP2alphaB/CBFa2, PEBP2alphaA/CBFa1, and PEBP2beta/CBFb were expressed in a murine endothelial cell line MSS31. The expression of these molecules as well as the DNA binding activity of PEBP2/CBF were augmented by angiogenic growth factors such as bFGF and VEGF. Moreover, the expression of PEBP2 alpha/CBFa protein in endothelial cells was confirmed at the site of angiogenesis in vivo. To further clarify the role of PEBP2/CBF in angiogenesis, we established permanent transfectants of PEBP2 beta-MYH11 gene, one that interacts with the runt domain of the alpha subunit and deregulates PEBP2/CBF in a dominant interfering manner. Proliferation, migration, and tube formation of the PEBP2 beta-MYH11 transfectants were significantly reduced in comparison with those activities of the mock transfectants. These results suggest that transcription factor PEBP2/CBF plays an important role in angiogenesis. (+info)

Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. (2/86)

Mammalian CBFB encodes a transcription factor (CBF beta) that in combination with CBF alpha 2 binds to specific DNA sequences and regulates expression of a number of hematopoietic genes. CBFB is associated with human leukemias through a chromosome 16 inversion and is essential for definitive hematopoiesis during mouse embryo development. We have isolated a zebrafish cbfb complementary DNA (cDNA) clone from a zebrafish kidney cDNA library. This cbfb is highly homologous to human and mouse CBFB/Cbfb genes at both the DNA and protein level. In biochemical analyses, cbfbeta binds to human CBF alpha 2 and enhances its DNA binding. During zebrafish development, cbfb is expressed in the lateral plate mesoderm at tail bud stage and in the intermediate cell mass (ICM, the location of embryonic hematopoiesis) between the 21- to 26-somite stages. The cbfb is also expressed in Rohon-Beard cells, cranial nerve ganglia, hindbrain, retina, branchial arches, jaw, and fin buds. Expression of cbfb is decreased or absent in the ICM and Rohon-Beard cells in some hematopoietic mutants and is unaffected in others. We have also analyzed the expression of scl and gata-1 in the same hematopoietic mutants to ascertain the relative order of these transcription factors to cbfb in zebrafish hematopoiesis. Our results indicate that cbfb is expressed in early hematopoietic progenitors and that its expression pattern in the hematopoietic mutants is similar to that of scl. (Blood. 2000;96:4178-4184) (+info)

Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. (3/86)

Core-binding factor beta (CBFbeta) is the non-DNA-binding subunit of the heterodimeric CBFs. Genes encoding CBFbeta (CBFB), and one of the DNA-binding CBFalpha subunits, Runx1 (also known as CBFalpha2, AML1, and PEBP2alphaB), are required for normal hematopoiesis and are also frequent targets of chromosomal translocations in acute leukemias in humans. Homozygous disruption of either the Runx1 or Cbfb gene in mice results in embryonic lethality at midgestation due to hemorrhaging in the central nervous system, and severely impairs fetal liver hematopoiesis. Results of this study show that Cbfb-deficient mouse embryonic stem (ES) cells can differentiate into primitive erythroid colonies in vitro, but are impaired in their ability to produce definitive erythroid and myeloid colonies, mimicking the in vivo defect. Definitive hematopoiesis is restored by ectopic expression of full-length Cbfb transgenes, as well as by a transgene encoding only the heterodimerization domain of CBFbeta. In contrast, the CBFbeta-smooth muscle myosin heavy chain (SMMHC) fusion protein generated by the inv(16) associated with acute myeloid leukemias (M4Eo) cannot rescue definitive hematopoiesis by Cbfb-deficient ES cells. Sequences responsible for the inability of CBFbeta-SMMHC to rescue definitive hematopoiesis reside in the SMMHC portion of the fusion protein. Results also show that the CBFbeta-SMMHC fusion protein transdominantly inhibits definitive hematopoiesis, but not to the same extent as homozygous loss of Runx1 or Cbfb. CBFbeta-SMMHC preferentially inhibits the differentiation of myeloid lineage cells, while increasing the number of blastlike cells in culture. (+info)

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. (4/86)

BCR/ABL fluorescent in situ hybridization study of chronic myeloid leukemia (CML) and Philadelphia(+) (Ph(+)) acute lymphoid leukemia (ALL) indicated that approximately 9% of patients exhibited an atypical hybridization pattern consistent with a submicroscopic deletion of the 5' region of ABL and the 3' region of the BCR genes on the 9q(+) chromosome. The CML patients with deletions had a shorter survival time and a high relapse rate following bone marrow transplant. Since deletions are associated with both Ph(+) CML and ALL, it seemed probable that other leukemia-associated genomic rearrangements may also have submicroscopic deletions. This hypothesis was confirmed by the detection of deletions of the 3' regions of the CBFB and the MLL genes in AML M4 patients with inv(16) and in patients with ALL and AML associated with MLL gene translocations, respectively. In contrast, analysis of the AML M3 group of patients and AML M2 showed that similar large deletions were not frequently associated with the t(15;17) or t(8;21) translocations. Analysis of sequence data from each of the breakpoint regions suggested that large submicroscopic deletions occur in regions with a high overall density of Alu sequence repeats. These findings are the first to show that the process of deletion formation is not disease specific in leukemia and also implicate that the presence of repetitive DNA in the vicinity of breakpoint regions may facilitate the generation of submicroscopic deletions. Such deletions could lead to the loss of one or more genes, and the associated haploinsufficiency may result in the observed differences in clinical behavior. (Blood. 2001;97:3581-3588) (+info)

Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse. (5/86)

PEBP2 beta/Cbf beta is the beta subunit of PEBP2/Cbf, which has been demonstrated to have important biological activities in hematopoiesis and osteogenesis. However, PEBP2 beta is ubiquitously expressed, suggesting that PEBP2 has other additionally important physiological activities. In an effort to elucidate other possible functions for PEBP2, we have isolated a novel gene that encodes a PEBP2 beta-interacting protein from a mouse cDNA library. We have called this gene Crl-1 for charged amino acid rich leucine zipper-1 (Crl-1) because it is rich in charged amino acids and contains a putative leucine zipper region. Expression studies in a 17.5 days post-coitum mouse embryo demonstrated Crl-1 expression mainly in the olfactory bulb and cerebral cortex. Post-natally, Crl-1 expression was additionally observed in the cerebellar cortex with strong expression in the hippocampus. These findings show that this novel PEBP2 beta-interacting protein is expressed mainly in subsets of neuronal cells, suggesting that Crl-1 plays some role in the developing mouse brain. (+info)

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. (6/86)

Core-binding factor beta (CBFbeta) and CBFalpha2 form a heterodimeric transcription factor that plays an important role in hematopoiesis. The genes encoding either CBFbeta or CBFalpha2 are involved in chromosomal rearrangements in more than 30% of cases of acute myeloid leukemia (AML), suggesting that CBFbeta and CBFalpha2 play important roles in leukemogenesis. Inv(16)(p13;q22) is found in almost all cases of AML M4Eo and results in the fusion of CBFB with MYH11, the gene encoding smooth muscle myosin heavy chain. Mouse embryos heterozygous for a Cbfb-MYH11 knock-in gene lack definitive hematopoiesis, a phenotype shared by Cbfb(-/-) embryos. In this study we generated a Cbfb-GFP knock-in mouse model to characterize the normal expression pattern of Cbfbeta in hematopoietic cells. In midgestation embryos, Cbfbeta was expressed in populations enriched for hematopoietic stem cells and progenitors. This population of stem cells and progenitors was not present in mouse embryos heterozygous for the Cbfb-MYH11 knock-in gene. Together, these data suggest that Cbfb-MYH11 blocks embryonic hematopoiesis at the stem-progenitor cell level and that Cbfb is essential for the generation of hematopoietic stem and progenitor cells. In adult mice, Cbfbeta was expressed in stem and progenitor cells, as well as mature myeloid and lymphoid cells. Although it was expressed in erythroid progenitors, Cbfbeta was not expressed during the terminal stages of erythropoiesis. Our data indicate that Cbfb is required for myeloid and lymphoid differentiation; but does not play a critical role in erythroid differentiation. (+info)

Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. (7/86)

Enhancers and promoters within TCR loci functionally collaborate to modify chromatin structure and to confer accessibility to the transcription and V(D)J recombination machineries during T cell development in the thymus. Two enhancers at the TCRalphadelta locus, the TCR alpha enhancer and the TCR delta enhancer (Edelta), are responsible for orchestrating the distinct developmental programs for V(D)J recombination and transcription of the TCR alpha and delta genes, respectively. Edelta function depends critically on transcription factors core binding factor (CBF)/polyoma enhancer-binding protein 2 (PEBP2) and c-Myb as measured by transcriptional activation of transiently transfected substrates in Jurkat cells, and by activation of V(D)J recombination within chromatin-integrated substrates in transgenic mice. To understand the molecular mechanisms for synergy between these transcription factors in the context of chromatin, we used in vivo footprinting to study the requirements for protein binding to Edelta within wild-type and mutant versions of a human TCR delta minilocus in stably transfected Jurkat cells. Our data indicate that CBF/PEBP2 plays primarily a structural role as it induces a conformational change in the enhanceosome that is associated with augmented binding of c-Myb. In contrast, c-Myb has no apparent affect on CBF/PEBP2 binding, but is critical for transcriptional activation. Thus, our data reveal distinct functions for c-Myb and CBF/PEBP2 in the assembly and function of an Edelta enhanceosome in the context of chromatin in vivo. (+info)

Core binding factor genes and human leukemia. (8/86)

BACKGROUND: The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFb, is essential for normal hematopoiesis. Recent studies have shown that mutations and gene rearrangements involving this complex are frequently implicated in leukemogenesis. Understanding the molecular events leading to the disruption of CBF has provided important insights into our understanding of the normal regulatory pathways that control hematopoiesis and has begun to reveal how alterations in these pathways induce leukemia. INFORMATION SOURCES: Both authors are involved in the identification and characterization of chromosomal abnormalities associated with hematologic malignancy. This has led to contributions to multicenter clinical and laboratory investigations as well as publications in peer-reviewed journals. All of the references cited in this review are published in journals covered by Medline. State of the Art. The core binding factor (CBF) is a heterodimeric transcription factor composed of the RUNX1 and CBFb subunits. RUNX1 is the DNA binding element of the complex and its affinity is greatly increased in the presence of CBFb. Knock-out studies in mice have demonstrated that both RUNX1 and CBFb are necessary for definitive hematopoiesis. Furthermore, reciprocal chromosomal translocations involving both partners have been directly implicated in leukemogenesis. Evidence is now emerging that at least some of the resulting fusion proteins, namely ETV6-RUNX1, RUNX1-MTG8 and CBFb-MYH11 dominantly inhibit the function of native CBF by recruiting transcriptional co-repressor complexes. However, knock-in studies have shown that whilst expression of these fusion genes may disrupt normal hematopoiesis, this, by itself, is not sufficient for the subsequent development of leukemia. Mutations of RUNX1 have been identified in familial platelet disorder (FDP), in which there is a congenital predisposition to the development of AML and heterozygous point mutations have been identified in the RUNX1 gene in some leukemias. Moreover, a small number of cases have been reported in which amplification of RUNX1 has been detected in childhood ALL suggesting mechanisms other than loss of function, such as gene dosage may also play a role. CONCLUSIONS: Understanding the role CBF plays in normal hematopoiesis and hematologic malignancies has provided critical reagents for the accurate identification of the broad group of leukemias harboring alterations of CBF. The application of these molecular approaches has already shown an impact on the clinical management of these patients and as more information becomes available, the ability to tailor therapy to improve each patient's chance of a cure becomes feasible. (+info)

Inversions are classified based on their location along the chromosome:

* Interstitial inversion: A segment of DNA is reversed within a larger gene or group of genes.
* Pericentric inversion: A segment of DNA is reversed near the centromere, the region of the chromosome where the sister chromatids are most closely attached.

Chromosome inversions can be detected through cytogenetic analysis, which allows visualization of the chromosomes and their structure. They can also be identified using molecular genetic techniques such as PCR (polymerase chain reaction) or array comparative genomic hybridization (aCGH).

Chromosome inversions are relatively rare in the general population, but they have been associated with various developmental disorders and an increased risk of certain diseases. For example, individuals with an inversion on chromosome 8p have an increased risk of developing cancer, while those with an inversion on chromosome 9q have a higher risk of developing neurological disorders.

Inversions can be inherited from one or both parents, and they can also occur spontaneously as a result of errors during DNA replication or repair. In some cases, inversions may be associated with other genetic abnormalities, such as translocations or deletions.

Overall, chromosome inversions are an important aspect of human genetics and can provide valuable insights into the mechanisms underlying developmental disorders and disease susceptibility.

Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by the alpha subunit as the ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...

https://en.wikipedia.org/wiki/CBFB

... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ...

https://en.wikipedia.org/wiki/Runt_domain

... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β′ The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...

https://en.wikipedia.org/wiki/RNA_polymerase

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the ... 1997). "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1". ... "Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2". Sawada J, Goto M, Watanabe H, et al. (1995). " ... GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene. ...

https://en.wikipedia.org/wiki/GABPB2

... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... "Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor ...

https://en.wikipedia.org/wiki/RUNX1

A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a ... Core binding factor RUNX1 RUNX2 GRCh38: Ensembl release 89: ENSG00000020633 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC (Jul 2004). "Transforming growth factor-beta stimulates p300- ... Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene. This gene encodes a member of the ...

https://en.wikipedia.org/wiki/RUNX3

Transcription factors bind to hypersensitive site cores and cause the LCR to form a loop that can interact with the promoter of ... hemoglobin subunit gamma-1 (fetal) HBD, hemoglobin subunit delta (adult) HBB, hemoglobin subunit beta (adult) There is an opsin ... Transcription factors bind to the LCR to form a complex. The complex moves along the DNA helix until it can bind to the ... Transcription factors bind to DNA from the LCR to the promoter in an orderly fashion using non-DNA-binding proteins and ...

https://en.wikipedia.org/wiki/Locus_control_region

The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...

https://en.wikipedia.org/wiki/Sigma_factor

... a beta, and a beta prime (α, α, β, and β'). A fifth subunit, sigma (called the σ-factor), is only present during initiation and ... The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ...

https://en.wikipedia.org/wiki/Bacterial_transcription

These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... This is composed of three alpha-helices separated by two beta strand-loop domains. Similar to NF-YA, NF-YB has been shown to ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...

https://en.wikipedia.org/wiki/CAAT_box

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... 2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general ...

https://en.wikipedia.org/wiki/GTF2A1L

The beta subunits are responsible for binding the RNAP to the DNA, preventing premature dissociation. In Escherichia coli, the ... As noted above in RNA Polymerase and Sigma Factors, the beta clamp proteins within the RNAP complex have a higher initial ... Eubacterial RNAP holoenzymes consist of a core with four major subunits α2 ββ'. In cyanobacteria, β' is formed from two smaller ... In E. coli, a repressor binds the DNA operon and dislodges RNAP due to the loosely bound beta clamp, whereas in Synechocystis, ...

https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803

TFIIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID, and the RPB1 ... TFIIB-related factor) which also contains a conserved zinc ribbon and C terminal core. However, the structure diverges in the ... It forms a beta sheet and an ordered loop that helps with the stability of the structure when transcription is initiated. The ... Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ...

https://en.wikipedia.org/wiki/Transcription_factor_II_B

... chimeric transcript that encodes a protein consisting of the first 165 residues from the N-terminus of core-binding factor beta ... Myosin-11 is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light ... 1998). "The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional ... chain subunits. It is a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ...

https://en.wikipedia.org/wiki/Myosin-11

Some of these transcription factors appear to form multi-protein DNA-bound complexes. Phosphorylation of the RHD appears to ... The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop ... The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. ... Biancalana M, Natan E, Lenardo MJ, Fersht AR (September 2021). "NF-κB Rel subunit exchange on a physiological timescale". ...

https://en.wikipedia.org/wiki/Rel_homology_domain

... binds to the beta-propeller of the DDB1 adaptor protein which interacts with numerous DDB1-CUL4-Associated Factors (DCAFs ... CRL4Cdt2 also degrades PCNA-bound PR-Set7/SET8, which is a histone 4 methyltransferase, and the p12 subunit of DNA polymerase δ ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZN1 and IKZN3 transcription factors, which are ...

https://en.wikipedia.org/wiki/CUL4B

This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is ...

https://en.wikipedia.org/wiki/SEC61B

NusG binds to termination factor Rho and to RNAP. It stimulates the rate of transcription elongation and is required for the ... antitermination change highly conserved amino acids located in a cysteine-rich amino-proximal domain of the RNAP beta' subunit ... The assembly of NusB, S10, and NusG onto the core complex involves nt 2 to 7 of lambda BOXA (CGCUCUUACACA), as well as the ... An additional factor or factors that can be supplied by a cellular extract are required, but their identities are unknown. ...

https://en.wikipedia.org/wiki/Antitermination

... binds to the beta-propeller of the DDB1 adaptor protein which interacts with numerous DDB1-CUL4-Associated Factors (DCAFs ... The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ...

https://en.wikipedia.org/wiki/CUL4A

Ruediger R, Fields K, Walter G (Jan 1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits ... "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ... "Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat ...

https://en.wikipedia.org/wiki/PPP2R2A

This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...

https://en.wikipedia.org/wiki/Sec61_alpha_1

... a subunit of the Mediator complex, which is required for the activity of the enhancer-binding protein Sp1. Elongin A, a subunit ... 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92-104. ... The hydrophobic core residues of helices 2, 3, and 4 are well conserved among TFIIS domains, although helix 1 is less conserved ... Mo X, Kowenz-Leutz E, Xu H, Leutz A (2004). "Ras induces mediator complex exchange on C/EBP beta". Mol. Cell. 13 (2): 241-50. ...

https://en.wikipedia.org/wiki/MED26

The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD10

4A19 60S subunit viewed from the solvent-exposed side, PDB identifiers 4A17, 4A19 The ribosomal RNA core is represented as a ... and eL40 would be positioned in the decoding site and near the translation factor binding site, respectively. These positions ... and several eukaryotic ribosomal proteins jointly to form inter-protein beta-sheets. Crystal structures of the eukaryotic ... Eukaryotic ribosomes have two unequal subunits, designated small subunit (40S) and large subunit (60S) according to their ...

https://en.wikipedia.org/wiki/Eukaryotic_ribosome

It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...

https://en.wikipedia.org/wiki/Ars_operon

These subunits are the two elongation factors, EF-Tu & EF-Ts, the ribosomal protein subunit S1, and the RNA dependent RNA ... elongation factor thermo unstable), catalyzing the release of guanosine diphosphate from EF-Tu. This enables EF-Tu to bind to a ... the core domain contains two subdomains, C and N which interact with domains 3 and 1 of EF-Tu respectively. EF-Ts functions as ... EF-Ts comprises the majority of the top portion of the protein, while EF-Tu makes up the bottom half where the beta barrels are ...

https://en.wikipedia.org/wiki/EF-Ts

... general transcription factor 2H subunit 5) is also known as the TTD group A (TTDA) subunit (and as Tfb5). The TTDA subunit is ... and part of a six-subunit complex of Rad3, Tfb1, Tfb2, Tfb4, Tfb5, and Ssl1 (referred to as core) In humans, the function of ... TTDA is present both bound to TFIIH, and as a free fraction that shuffles between the cytoplasm and nucleus; induction of NER- ... These proteins have a structural motif consisting of a 2-layer sandwich structure with an alpha/beta plait topology. ...

https://en.wikipedia.org/wiki/Tbf5_protein_domain

Once bound to DNA, the beta subunits can freely slide along double stranded DNA. The beta subunits in turn bind the αε ... MacNeill SA (August 2016). "PCNA-binding proteins in the archaea: novel functionality beyond the conserved core". Current ... DNA clamps also associate with other factors involved in DNA and genome homeostasis, such as nucleosome assembly factors, ... The gamma complex of DNA polymerase III, composed of γδδ'χψ subunits, catalyzes ATP to chaperone two beta subunits to bind to ...

https://en.wikipedia.org/wiki/DNA_clamp

... one beta (β), one beta prime (β'), and one omega (ω) subunits that make up the core enzyme(~450 kDa). In addition, many ... also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter ... The RNA polymerase core associates with the sigma factor to form RNA polymerase holoenzyme. Sigma factor reduces the affinity ... The core enzyme of RNA polymerase has five subunits (protein subunits) (~400 kDa). Because of the RNA polymerase association ...

https://en.wikipedia.org/wiki/General_transcription_factor

Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and ... 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure ... Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ...

https://en.wikipedia.org/wiki/PPP2R1A

The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD7

In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L (December 1998). "Interleukin-10 and transforming growth factor-beta ... November 1993). "A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase". ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ...

https://en.wikipedia.org/wiki/Promoter_(genetics)

"The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and ... "Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the ... hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors ... However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ...

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

The gene PSMB3 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ... Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the ...

https://en.wikipedia.org/wiki/PSMB3

Formation of the preinitiation complex begins when the multi-subunit transcription factor II D (TFIID) binds to the TATA box at ... The type of core promoter affects the level of transcription and expression of a gene. TATA-binding protein (TBP) can be ... Zienolddiny S, Ryberg D, Maggini V, Skaug V, Canzian F, Haugen A (April 2004). "Polymorphisms of the interleukin-1 beta gene ... It binds transcription factors (CAAT TF or CTFs) and thereby stabilizes the nearby preinitiation complex for easier binding of ...

https://en.wikipedia.org/wiki/TATA_box

... with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit ... is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11916-20. doi: ... a pheromone desensitization factor in Saccharomyces cerevisiae". Mol Cell Biol. 15 (7): 3635-43. doi:10.1128/MCB.15.7.3635. PMC ... G protein gamma subunit-like) for binding G protein beta subunits (InterPro: IPR001770 Those RGS proteins that contain GGL ...

https://en.wikipedia.org/wiki/Regulator_of_G_protein_signaling

For example, after binding the enhancer and core promoter, the mediator complex undergoes a compositional change in which the ... The yeast Saccharomyces cerevisiae (a simple eukaryote) is thought to have up to 21 subunits in the core mediator (exclusive of ... Kato Y, Habas R, Katsuyama Y, Näär AM, He X (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal ... Thus, the structure of a mediator complex can be augmented by RNA as well as proteinaceous transcription factors. Mediator was ...

https://en.wikipedia.org/wiki/Mediator_(coactivator)

Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex ... This compact globular beta-grasp fold is found in ubiquitin, UBLs, and proteins that comprise a ubiquitin-like domain, e.g. the ... Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (March 1999). "A novel ubiquitination factor, E4, is involved in ... This is a barrel-shape structure comprising a central proteolytic core made of four ring structures, flanked by two cylinders ...

https://en.wikipedia.org/wiki/Ubiquitin

The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... Deveraux Q, Ustrell V, Pickart C, Rechsteiner M (1994). "A 26 S protease subunit that binds ubiquitin conjugates". J. Biol. ... composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD5

SCF-Coi1 then binds the JAZ transcription factor and targets it for degradation. Degradation of the JAZ transcription factor ... SCF contains a variable F-box protein and three core subunits: F-box protein (FBP) - FBP contributes to the substrate ... Beta-transducin repeat-containing protein (βTRCP) is an FBP that targets emi1-an APC/C-Cdh1 inhibitor-and wee1 for degradation ... Skp2 binds p27Kip1 only when two conditions are met: p27Kip1 is phosphorylated by E/A/CKD2 and bound to Cks1. As a consequence ...

https://en.wikipedia.org/wiki/SCF_complex

Volume 1. Core Clinical Skills. Oxford University Press. 2010. referenced in Bindu, LH; Reddy, PP (2008). "Genetics of ... Specifically, binding impairs translational proofreading leading to misreading of the RNA message, premature termination, or ... See Also Fischel-Ghodsian, N (1999). "Genetic factors in aminoglycoside toxicity". Ann N Y Acad Sci. 884: 99-109. doi:10.1111/j ... In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for ...

https://en.wikipedia.org/wiki/Aminoglycoside

Core-binding factor (CBF) is a heterodimeric transcription factor composed by the CBFβ and RUNX subunits (the latter is encoded ... Adya N, Stacy T, Speck NA, Liu PP (December 1998). "The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle ... August 1993). "Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia". ... "core binding factor AML" (CBF AML) [WHO classification] is the most common group of AML, including groups with the chromosome ...

https://en.wikipedia.org/wiki/AI-10-49

"Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors". ... "The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein". ... N terminus helical domains of the two subunits form a coiled coil with one another that typically extends away from the core of ... The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ...

https://en.wikipedia.org/wiki/G_beta-gamma_complex

The UBA3 subunit contains the catalytic center and activates NEDD8 in an ATP-dependent reaction by forming a high-energy ... Walker JR, Corpina RA, Goldberg J (August 2001). "Structure of the Ku heterodimer bound to DNA and its implications for double- ... Wu K, Chen A, Tan P, Pan ZQ (January 2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged ... beta(TrCP))-dependent ubiquitination of IkappaBalpha". Molecular and Cellular Biology. 20 (7): 2326-33. doi:10.1128/MCB.20.7. ...

https://en.wikipedia.org/wiki/NEDD8

"Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells". ... The EF-hand types, united by an anti-parallel beta-strand between loops L1 and L3, are located on the same side of the molecule ... Munz B, Gerke V, Gillitzer R, Werner S (Mar 1997). "Differential expression of the calpactin I subunits annexin II and p11 in ... by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. The ...

https://en.wikipedia.org/wiki/S100A10

2004). "CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP 2 binding protein". Neuron. 43 (4): 551-562. ... Some of the factors involved in PIP2 regulation are: Lipid kinases, Lipid Phosphatase Lipid Transfer Proteins Growth Factors, ... which is initiated by ligands binding to G protein-coupled receptors activating the Gq alpha subunit. PtdIns(4,5)P2 is a ... This stabilizes GRK2 and also orients it in a way that allows for more efficient phosphorylation of the beta adrenergic ...

https://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate

This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... In this process, Cables 1 mechanistically interferes the proteasome subunit alpha type-3 (PMSA3) hereby binding to p21 to ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMA3

In the hexameric configuration, the ATP-binding site is positioned at the interface between the subunits. Upon ATP binding and ... The AAA domain contains two subdomains, an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold ... AAA proteins are divided into seven basic clades, based on secondary structure elements included within or near the core AAA ... "Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP". Nat. Struct. ...

https://en.wikipedia.org/wiki/AAA_proteins

... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity. Multidomain cellulases are ... Cellulose 1,4-beta-cellobiosidase, an efficient cellulase Cellulase unit, a unit for quantifying cellulase activity PDB: 1NLR ... construction of the catalytic core, expression, and X-ray structure at 1.75 Å resolution". Biochemistry. 36 (51): 16032-9. doi: ...

https://en.wikipedia.org/wiki/Cellulase

... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... The SeV virion also contains the nucleocapsid core, which is composed of the genomic RNA, the nucleocapsid protein (NP), the ... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ...

https://en.wikipedia.org/wiki/Murine_respirovirus

SMARCB1 is a core protein subunit of the 15 subunit SWI/SNF (or BAF) complex involved in regulating the nucleosome architecture ... "Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma". Virchows ... Upon ligand binding, EGFR phosphorylation triggers the activation of downstream signaling pathways involved in critical ... thyroid hormone receptor beta, and nuclear receptor coactivator 1, among others. Cyclin D and CDKs promote cell cycle ...

https://en.wikipedia.org/wiki/Epithelioid_sarcoma

... that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ... Proteasome subunit beta type-10 is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and ...

https://en.wikipedia.org/wiki/PSMB10

... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... beta-2 microglobulin MeSH D12.776.377.715.182.160 - beta-thromboglobulin MeSH D12.776.377.715.182.200 - complement factor h ... hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, gag-pol MeSH D12.776.964.775.375.335 - hiv integrase MeSH ... immunoglobulin subunits MeSH D12.776.377.715.548.705.500 - immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

GluN1 subunits bind the co-agonist glycine and GluN2 subunits bind the neurotransmitter glutamate. The agonist-binding module ... Another factor that seems to affect NMDAR induced toxicity is the observed variation in subunit makeup. NMDA receptors are ... Yang ST, Wang M, Paspalas CD, Crimins JL, Altman MT, Mazer JA, Arnsten AF (April 2018). "Core Differences in Synaptic Signaling ... a process that is independent of neuregulin beta signaling through ErbB2 and ErbB4 receptors. NMDA receptors have been ...

https://en.wikipedia.org/wiki/NMDA_receptor

core-binding factor subunit beta [Rattus norvegicus] core-binding factor subunit beta [Rattus norvegicus]. gi,61557239,ref,NP_ ... core-binding factor subunit beta [Rattus norvegicus]. NCBI Reference Sequence: NP_001013209.1 ... Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse. [Mol Endocrinol. 2016] Core Binding ... Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; protein ...

http://www.ncbi.nlm.nih.gov/protein/NP_001013209

... also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds ... The core elements of the SL3 virus are im … ... to an element termed the core within the enhancers of the ... Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores A L ... Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores A L ...

https://pubmed.ncbi.nlm.nih.gov/7707514

... which is one piece of a protein complex known as core binding factor (CBF). Learn about this gene and related health conditions ... The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), ... SL3-3 enhancer factor 1 subunit beta. *SL3/AKV core-binding factor beta subunit ... The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a ...

https://medlineplus.gov/genetics/gene/cbfb/

MeSH Terms: Animals; Chick Embryo; Chickens; Core Binding Factor Alpha 1 Subunit/genetics; Core Binding Factor Alpha 1 Subunit/ ... Transforming growth factor beta 2 (TGFβ2) mediates activation during cardiac endothelial EMT. Consistent with a role in ... Abstract: Although normally linked to bone and cartilage development, the Runt-related transcription factor, RUNX2, was ... and continued expression in adenocarcinoma.These data introduce the RUNX2-I isoform as a critical early transcription factor ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3305109

4. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.. Miller J; Horner A; Stacy ... 2. Core-binding factor beta interacts with Runx2 and is required for skeletal development.. Yoshida CA; Furuichi T; Fujita T; ... Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in ... Core-binding factor: a central player in hematopoiesis and leukemia.. Speck NA; Stacy T; Wang Q; North T; Gu TL; Miller J; ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=12434156&mod=related&page=1&outid=&proj=

Core Binding Factor beta Core Binding Factor beta Protein Polyomavirus Enhancer Binding Protein 2, beta Subunit Registry Number ... Transcription Factors [D12.776.930] * Core Binding Factors [D12.776.930.155] * Core Binding Factor alpha Subunits [D12.776. ... A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE ... A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE ...

https://meshb.nlm.nih.gov/record/ui?ui=D050658

Core Binding Factor beta Subunit Entry term(s). CBFB Protein Core Binding Factor beta Core Binding Factor beta Protein ... Core Binding Factor beta. Core Binding Factor beta Protein. Polyomavirus Enhancer Binding Protein 2, beta Subunit. ... Core Binding Factor beta Subunit - Preferred Concept UI. M0477050. Scope note. A non-DNA binding transcription factor that is a ... A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE ...

https://decs.bvsalud.org/en/ths/resource/?id=51179&filter=ths_exact_term&q=SUBUNIDAD+BETA+DEL+FACTOR+DE+UNI%C3%93N+AL+SITIO+PRINCIPAL

https://meshb-prev.nlm.nih.gov/record/ui?ui=D050658

ABBREVIATIONS: AMPK, AMP-activated protein kinase; BioID, biotinylation identification; CBFB, core-binding factor subunit beta ... 5-bisphosphate 3-kinase catalytic subunit alpha; TUFM, Tu translation elongation factor, mitochondrial; ETC, electron transport ... We also identified three adverse factors: epidermal growth factor receptor mutations (OS: 1.57 [1.06, 2.32], p = .02), with ... The aim of this study was to understand the spatial and temporal evolution and external factors of DECS in Chinese cities and ...

https://pesquisa.bvsalud.org/portal/?lang=es&q=au:Luo,+Ji

SL3/AKV core-binding factor alpha C subunit. Description. RUNX3 is a member of the runt domain-containing family of ... transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5- ... It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or ... we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. The centers ...

https://edrn.nci.nih.gov/data-and-resources/biomarkers/runx3/

core-binding factor subunit beta Q08024. Ccdc80. coiled-coil domain-containing protein 80 Q8R2G6. ... tumor necrosis factor receptor superfamily member 23. Q9ER63. Tomm20. mitochondrial import receptor subunit TOM20 homolog. ... ATP-binding cassette sub-family E member 1. P61222. Adamts1. A disintegrin and metalloproteinase with thrombospondin motifs 1 ... UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7. Q8K0J2. Bcat1. branched chain aminotransferase 1, cytosolic. ...

https://esbl.nhlbi.nih.gov/Signaling-Pathways/Vasopressin-mRNAs/

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the ... The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the ... produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion ... CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding ...

https://pharos.nih.gov/targets/CBFB

Polyomavirus enhancer binding protein (PEBP)2beta/core binding factor [CBF]beta, a heterodimerizing partner of AML1 that is ... The Pebpb2/Cbfb gene encodes the non-DNA binding beta subunit of the heterodimeric transcription factor, PEBP2/CBF, and has ... Transcription factors of the AML (core binding factor-alpha/polyoma enhancer binding protein 2) class are key transactivators ... within the human T-cell receptor beta gene enhancer each contain consensus binding sites for the Ets and core binding factor ( ...

https://www.sdbonline.org/sites/FLY/segment/runt2b.htm

Core Binding Factor Alpha 3 Subunit N0000169995 Core Binding Factor alpha Subunits N0000169994 Core Binding Factor beta Subunit ... N0000171389 Cord Factors N0000169996 Core Binding Factor Alpha 1 Subunit N0000169998 Core Binding Factor Alpha 2 Subunit ... Gs N0000170553 GTP-Binding Protein beta Subunits N0000170551 GTP-Binding Protein gamma Subunits N0000170501 GTP-Binding Protein ... Factor IX N0000171470 Factor IXa N0000171494 Factor V N0000171495 Factor Va N0000007576 Factor VII N0000006521 Factor VIIa ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202007-10-09.txt

CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding ... A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/.bkup/mshnew2006.10-03-2005.txt

AP71295 Recombinant human Core-binding factor subunit beta 11055 6930 4125 2508 1452 0 1012 E.coli HUMAN His-SUMO-tag Store at ... AP71626 Recombinant human Serine/threonine-protein phosphatase 2A regulatory subunit B subunit beta 11055 6930 4125 2508 1452 ... AP71149 Recombinant mouse Hemoglobin subunit beta-2 16280 10230 6094 3707 2145 0 1507 E.coli MOUSE GST-tag Store at -20°C, for ... AP70884 Recombinant human Thyrotropin subunit beta 11055 6930 4125 2508 1452 0 1012 E.coli HUMAN His-tag Store at -20°C, for ...

http://www.thesixteendigital.com/Products-30737754.html

This subunit forms the core of the heterotrimer. The alpha and beta subunits bind the gamma, but do not interact together. ... Furthermore, the isolated C-domain of aIF2alpha is responsible for binding of the alpha subunit to gamma. This binding involves ... aIF2gamma shows a high resemblance with elongation factor EF1-A. In this study, we characterize the role of each subunit in the ... Site-directed mutagenesis confirms a binding mode of the tRNA molecule similar to that observed with the elongation factor. ...

https://hal-polytechnique.archives-ouvertes.fr/hal-00770710v1

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. ... The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve ... the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. ...

https://pharos.ncats.nih.gov/targets/GTF2A1L

The PH domain in beta-adrenergic receptor kinase may be involved in binding to the beta gamma subunits of a trimeric G-protein ... The core of the molecule is an antiparallel beta-sheet consisting of seven strands. The C terminus is folded into a long alpha- ... A family of NMR solution structures of the growth factor receptor-bound protein 2 (Grb2) SH2 domain has been determined by ... The domains can bind phosphatidylinositol within biological membranes and proteins such as the beta/gamma subunits of ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=PH&START=438&END=546&E_VALUE=2.33e-14&TYPE=SMART&BLAST=LIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRDVLYYKGRLDMDDLEVVDVEDGKDRDLHVSVKNAFRLYCGTTGDSHLLCARKPEQKQRWLKAFAREREQV

Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. ... Neurotrophic Factor-a1: A Key Wnt-ß-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic ... A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking.Mol Cell Neurosci. 2019 Jul;98:121- ... Neurotrophic factor-α1, a novel tropin is critical for the prevention of stress-induced hippocampal CA3 cell death and ...

https://www.nichd.nih.gov/about/org/dir/other-facilities/cores/microscopyandimaging/publications

The nature of the binding of L-tryptophan in clefts between adjacent beta-sheets in the beta-wheel suggests that this binding ... Transcription termination factor rho from Escherichia coli is a homohexamer of 419 amino acid subunits and catalyzes an ATP- ... The effects of core-packing on the structure, function and mechanics of the RNA-binding 4-helix-bundle Rop have been studied by ... The nucleotide is bound predominantly to one subunit, with conserved residues from a second subunit making up one wall of the ...

https://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=CSP

... infertility is mutation in the gene encoding the beta subunit of luteinizing hormone, an important factor in the ... Methyl-CpG-binding proteins, such as MeCP2, bind to methylated DNA and recruit histone deacetylases. Hypoacetylated DNA is ... However, the methylation of core differential methylation regions of imprinted genes is somehow protected from both of these ... Finally, a mutation in the gene encoding the beta subunit of LH was found in two women with endometriosis. Genome-wide studies ...

https://grants.nih.gov/grants/guide/pa-files/PA-01-005.html

... basic helix-loop-helix transcription factor). 背景介绍. The alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1 ... Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation ... Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding. Phosphorylation by GSK3-beta and ... which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic ...

https://www.arigobio.cn/anti-HIF-1-alpha-antibody-ESEE122-ARG10515.html

... subunits; 3 layers: b/b/a. *. d.338: Oxysterol-binding protein-like [143999] (1 superfamily). core: large meander beta-sheet of ... beta-alpha-beta(2)-alpha; 2 layers: alpha/beta. *. d.202: Transcription factor NusA, N-terminal domain [69704] (1 superfamily) ... core: beta-alpha-beta(4); 2 layers: alpha/beta. *. d.39: DLC [54647] (1 superfamily). core: beta-alpha(2)-beta-X-beta(2); 2 ... d.41: alpha/beta-Hammerhead [54664] (5 superfamilies). core: beta-BETA-alpha-beta-BETA-beta-alpha; contains a beta-hammerhead ...

https://scop.berkeley.edu/sunid=53931&ver=2.03

6. Human Telomere Repeat Binding Factor TRF1 Replaces TRF2 Bound to Shelterin Core Hub TIN2 when TPP1 Is Absent.. Janovič T; ... TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.. Xin H; Liu D; Wan M; Safari A; Kim H; ... Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic ... Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.. Frescas D; de Lange T. J ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=37149272&mod=related&page=1&outid=&proj=

... beta subunits. The beta subunits exhibit active protein digesting activity. The digestion occurs on the sides of the enzymes ... The core of the proteasome is bound on each end to a (19S) regulatory protein. The 19S cap proteins are responsible for the ... The ability of a particular transcription factor to bind to its target gene is, in part, dependent on modifications that are ... In the normal process, growth factors that are excreted by other cells bind to receptors on the cell surface, stimulating the ...

https://cancerquest.org/patients/treatments/targeted-therapies

"Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ... "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & ... "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ... Anderson LA, Perkins ND (August 2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1 ...

https://www.wikidoc.org/index.php/HDAC1

Capz alpha-1 subunit. e.43.1.2. - Capz beta-1 subunit. e.3.1.1. - beta-Lactamase/D-ala carboxypeptidase. e.3.1.2. - Glutaminase ... Orbivirus core. e.28.1.2. - Phytoreovirus core. e.42.1.1. - L-A virus major coat protein. e.48.1.1. - Major capsid protein VP5 ... Poxvirus poly(A) polymerase catalytic subunit-like. e.41.1.1. - Adenylylcyclase toxin (the edema factor). e.10.1.1. - ... 39 kda initiator binding protein, IBP39, C-terminal domains. e.50.1.1. - AF1104-like. e.72.1.1. - Cas DxTHG. e.51.1.1. - ...

http://mulpssm.mbu.iisc.ernet.in/pali_names_E.html

... the TATA box-binding protein (TBP), the core factor (CF) heterotrimer and the Rrn3 protein (Moss et al., 2007). While the first ... The central part of Rrn3 contacts both the stalk-binding domain in subunit A135 and the dock domain in subunit A190 at Pol I- ... 2 mM beta-mercaptoethanol) supplemented with protease inhibitors (cOmplete EDTA-free, Roche, Switzerland). Cells were sonicated ... Rrn3 binding to Pol I is a prerequisite for enzyme recruitment to promoter-bound initiation factors (Keener et al., 1998; ...

https://elifesciences.org/articles/20832

CBFβ attaches (binds) to one of three related RUNX proteins (RUNX1, RUNX2, or RUNX3) to form different versions of CBF. (medlineplus.gov)
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). (nih.gov)
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
The past few years have witnessed remarkable progress in knowledge of the structure and function of RNA-binding proteins and their RNA complexes. (embl-heidelberg.de)
X-ray crystallography and NMR spectroscopy have provided structures for all major classes of RNA-binding proteins, both alone and complexed with RNA. (embl-heidelberg.de)
RNA-binding strategies common to cold-shock domain- and RNA recognition motif-containing proteins. (embl-heidelberg.de)
Numerous RNA-binding proteins have modular structures, comprising one or several copies of a selective RNA-binding domain generally coupled to an auxiliary domain that binds RNA non-specifically. (embl-heidelberg.de)
The importin-beta also helps over 100 million free mutations of downstream model proteins, acetylation-defective as the polymerase for the Law Commission of Canada, which upstream longer is. (evakoch.com)
Post-transcriptional processes mediated by mRNA binding proteins represent important control points in gene expression. (nih.gov)

RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (nih.gov)

These protein complexes bind to specific regions of DNA and help turn on (activate) certain genes. (medlineplus.gov)
Once bound to DNA, the RUNX1 protein controls the activity of genes involved in the development of blood cells (hematopoiesis). (medlineplus.gov)
14. Core binding factor genes and human leukemia. (nih.gov)
It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS , and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (nih.gov)
Forma complejos heterodiméricos con las SUBUNIDADES ALFA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL, y regula la TRANSCRIPCIÓN de diversos GENES involucrados principalmente en la DIFERENCIACIÓN CELULAR y en la progresión del CICLO CELULAR. (bvsalud.org)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (arigobio.cn)
β-catenin transactivation leads to enhanced T-cell factor (TCF)/lymphoid enhancer factor (LEF)-driven transcription of genes, such as CCND1 (encoding cyclin D1) and MYC (encoding c-Myc) ( 7 - 9 ). (frontiersin.org)
These epigenetic modifications occur in key oncogenes, tumor suppressor genes, and transcription factors, leading to cancer initiation and progression. (oncotarget.com)
The genetic background of myomas varies significantly and the most common genetic causes are mutations in genes Mediator complex subunit 12 (MED12), Fumarate hydratase (FH) or YEATS Domain containing 4 (YEATS4) , rearrangements affecting the High Mobility Group AT-hook 2 (HMGA2), and deletions in COL4A5/6 locus. (helsinki.fi)
efficiently, cytoskeletal binding download might assist reduced to complement cellular institutions in human but clinical oligosaccharide genes that would specifically result to factor tyrosine, while the chromosomal glycoprotein consists of p52 formation for autophagic lamins to share the apoptosis of cyteine junction grain after ligament. (evakoch.com)

The CBFB gene provides instructions for making a protein called core binding factor beta (CBFβ), which is one piece of a protein complex known as core binding factor (CBF). (medlineplus.gov)

5. Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. (nih.gov)

1. Core-binding factor beta interacts with Runx2 and is required for skeletal development. (nih.gov)
10. Runx2, a multifunctional transcription factor in skeletal development. (nih.gov)
15. Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1. (nih.gov)
Mechanistically, Wnt3a-heparin signaling strongly activates the phosphoinositide 3-kinase/Akt pathway and requires the bone-related transcription factor RUNX2 to stimulate alkaline phosphatase activity, which parallels canonical beta-catenin signaling. (umassmed.edu)
Collectively, our findings establish the osteo-inductive potential of a heparin-mediated Wnt3a-phosphoinositide 3-kinase/Akt-RUNX2 signaling network and suggest that heparan sulfate supplementation may selectively reduce the therapeutic doses of peptide factors required to promote bone formation. (umassmed.edu)

CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. (nih.gov)
Our mutational analysis, based on the electron cryomicroscopy structures of monomeric Pol I alone and in complex with Rrn3, underscores the central role of subunits A43 and A14 in the regulation of differential Pol I complexes assembly and subsequent promoter association. (elifesciences.org)

RUNX3 is a member of the runt domain-containing family of transcription factors. (nih.gov)

AP70864 Recombinant sheep Tumor necrosis factor 16280 10230 7678 4664 2706 0 1903 E.coli SHEEP His-tag Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. (thesixteendigital.com)
AP70865 Recombinant Human Tumor necrosis factor-inducible gene 6 protein 11055 6930 4125 2508 1452 0 1012 E.coli HUMAN GST-tag Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. (thesixteendigital.com)
AP70867 Recombinant human Tumor necrosis factor receptor superfamily member 21 11055 6930 4125 2508 1452 0 1012 E.coli HUMAN His-tag Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. (thesixteendigital.com)
To determine how the latter mutation impaired b subunit synthesis, recombinant b subunit bearing the mutation was expressed in BHK cells. (embl.de)

A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. (nih.gov)
The alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. (arigobio.cn)
The two largest subunits, A190 and A135, forming the DNA-binding cleft and harbouring the active centre, are held together by the AC40/AC19 assembly heterodimer. (elifesciences.org)
Subunit A12.2 contains a TFIIS-like C-terminal zinc ribbon located next to the active site, while the A49/A34.5 heterodimer attaches on the Pol I lobe through a TFIIF-like dimerization module. (elifesciences.org)
Finally, the A43/A14 heterodimer forms a stalk that emerges from the enzyme core. (elifesciences.org)

The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. (nih.gov)

They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. (nih.gov)
It is related in sequence and structure to ACTIN and binds ATP. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Our results further show that the respective auxiliary domains, despite their lack of sequence homology, are functionally equivalent and indispensable for modulating the properties of the specific RNA-binding domains. (embl-heidelberg.de)
Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (arigobio.cn)

In FRS levels of three concentrations each, the mutations download complexity lower and binding serve converted to fact and pathway Once. (erik-mill.de)

normal document, as, can also phosphorylate the stress of both components with heterodimers, Replacing factors that can enter involved further by ORs of quantum heparin-binding surface and reproductive primary beta-chain quality( Tamaki et al. (erik-mill.de)

It also interacts with other transcription factors. (nih.gov)
Their subtypes are known to express various transcription factors (TFs), such as Nkx6-1, Vsx2 and Skor1 marking the glutamatergic neuron precursors in the ventral rhombomere 1. (helsinki.fi)

Three models of Mtb biofilm formation have been proposed to study the factors regulating biofilm formation, the physiology of the resident bacteria, and the nature of the biomaterial that holds these bacterial masses together. (microbialcell.com)
Dr. Bowen currently co-directs the medical school's pharmacology course, teaches in endocrinology and neuroscience courses for undergraduates, and co-directs the core pharmacology course for the Molecular Pharmacology and Physiology Graduate Program. (brown.edu)

Protein Serine-threonine kinases that phosphorylate the 63-kDa subunit of AMP-ACTIVATED PROTEIN KINASES. (nih.gov)

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. (nih.gov)
Cell growth requires synthesis of ribosomal RNA by RNA polymerase I (Pol I). Binding of initiation factor Rrn3 activates Pol I, fostering recruitment to ribosomal DNA promoters. (elifesciences.org)

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. (nih.gov)

A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. (embl.de)
Molecular and cellular basis of deficiency of the b subunit for factor XIII secondary to a Cys430-Phe mutation in the seventh Sushi domain. (embl.de)
These studies demonstrate that a Cys430-Phe mutation does not prevent the de novo synthesis of the b subunit, but alters the conformation of the mutant protein sufficiently to impair its intracellular transport, resulting in its deficiency in this patient. (embl.de)
β-catenin can be activated not only by Wnt ligands but also by receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR), whose mutation or overexpression of EGFR gene occurs in many types of human cancer, including more than 50% of glioblastoma (GBM) ( 10 , 11 ). (frontiersin.org)

The solution structure of the 16th CCP module from human complement factor H has been determined by a combination of 2-dimensional nuclear magnetic resonance spectroscopy and restrained simulated annealing. (embl.de)

4. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. (nih.gov)

The protein produced from the fusion gene, called CBFβ-MYH11, can still bind to RUNX1 to form CBF. (medlineplus.gov)
The presence of CBFβ-MYH11 may block binding of CBF to DNA, preventing RUNX1 from controlling gene activity. (medlineplus.gov)
8. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. (nih.gov)
9. Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain. (nih.gov)

The presence of CBFβ helps the complex bind to DNA and protects the RUNX protein from being broken down. (medlineplus.gov)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
Our model of the CSD(FRG)-RNA complex constitutes the first prediction of the three-dimensional structure of a CSD-RNA complex and is consistent with the hypothesis of a convergent evolution of CSD and RRM towards a related single-stranded RNA-binding surface. (embl-heidelberg.de)
RNA passes through the hole of the protein hexamer in the complex with the Escherichia coli Rho factor. (embl-heidelberg.de)
Escherichia coli transcription termination factor Rho is a ring-shaped hexameric protein that uses the energy derived from ATP hydrolysis to dissociate RNA transcripts from the ternary elongation complex. (embl-heidelberg.de)
Five rather globular subunits present in all nuclear RNA polymerases (Rpb5, Rpb6, Rpb8, Rpb10 and Rpb12) attach on the periphery of the complex. (elifesciences.org)
Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF). (berkeley.edu)

However, the apparent molecular weight of the mutant was slightly higher than those of the wild-type and plasma b subunits under nonreducing conditions, probably because of destruction of a disulfide bond. (embl.de)

Binding of RNA and single-stranded DNA (poly(dC)) caused strong protection at several accessible parts of the oligosaccharide/oligonucleotide binding (OB) fold in the RNA binding domain. (embl-heidelberg.de)

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
12. Core-binding factor: a central player in hematopoiesis and leukemia. (nih.gov)

The Rho polypeptide has a distinct RNA binding domain of known structure as well as an ATP binding domain for which a structure has been proposed based on homology modeling. (embl-heidelberg.de)
The binding of ATP caused one distinct change in the cleavage pattern, a strong protection at a cleavage point in the P-loop of the ATP binding domain. (embl-heidelberg.de)
These results suggest that Rho has two distinct binding sites for RNA. (embl-heidelberg.de)

It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Identification of an RNA-binding Site in the ATP binding domain of Escherichia coli Rho by H2O2/Fe-EDTA cleavage protection studies. (embl-heidelberg.de)
RNA molecules but not DNA molecules also caused a strong, ATP-dependent protection at a cleavage site in the predicted Q-loop of the ATP binding domain. (embl-heidelberg.de)
Besides the site composed of multiples of the RNA binding domain, to which single-stranded DNA as well as RNA can bind, it has a separate, RNA-specific site on the Q-loop in the ATP binding domain. (embl-heidelberg.de)
and 3) near the proposed secondary RNA-binding site in the ATP-binding domain (Cys-325 Rho). (embl-heidelberg.de)
The sushi domain folds into a small and compact hydrophobic core enveloped by six beta-strands and stabilised by two disulfide bridges. (embl.de)
other such membranes are reviewed translated from the agents of interaction factors with lamellar sugars of treatment domain( XP), phosphatase( TTD), and Cockayne's file. (erik-mill.de)

The music of unliganded diabetes cirrhosis outside the treasure of DNA amino transports the transcription of materials indicating the ketoacyl-CoA H3 Reactive CenH3( however viewed CENP-A). arm manuscript isoform( NER) bound exclusively required in the binding majority E. signals as a history whereby astrocytic epithelium cancer yields not involved from DNA, signaling the Failure of surface receptor and generating heme. (erik-mill.de)

Although patients with SCD have a mutant gene for a component of adult hemoglobin, their gene for gamma globin, the novel subunit of fetal hemoglobin, is not mutated. (nih.gov)
The aim of this study was to analyze the CRP gene allelic variations in the Turkish adult risk factor (TARF) study and relate them with serum CRP levels as well as MetS and its components. (nih.gov)

pathway subunits by sites. (erik-mill.de)
The binding enters also in the pathway. (erik-mill.de)

The absent download физико химическая и binding Bona of oncogenic codon response city. (evakoch.com)

In the proposed quaternary structure of Rho, the Q-loops from the six subunits form the upper entrance to the hole in the ring-shaped hexamer through which the nascent transcript is translocated by actions coupled to ATP hydrolyses. (embl-heidelberg.de)

May function as a testis specific transcription factor. (nih.gov)

AB - OBJECTIVE: Serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease and metabolic syndrome (MetS). (nih.gov)

Anatomy1

Diseases1

Chemicals and Drugs10

Phenomena and Processes2

Information Science1

Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. (1/86)

Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. (2/86)

Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. (3/86)

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. (4/86)

Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse. (5/86)

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. (6/86)

Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. (7/86)

Core binding factor genes and human leukemia. (8/86)

Core Binding Factor beta Subunit

Core Binding Factors

Core Binding Factor alpha Subunits

Core Binding Factor Alpha 2 Subunit

Transcription Factor AP-2

Core Binding Factor Alpha 1 Subunit

Smooth Muscle Myosins

Transforming Growth Factor beta

Transcription Factors

Chromosomes, Human, Pair 16

DNA-Binding Proteins

Molecular Sequence Data

Chromosome Inversion

Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. (1/86)

Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. (2/86)

Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. (3/86)

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. (4/86)

Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse. (5/86)

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. (6/86)

Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. (7/86)

Core binding factor genes and human leukemia. (8/86)

CBFB

Runt domain

RNA polymerase

GABPB2

RUNX1

RUNX3

Locus control region

Sigma factor

Bacterial transcription

CAAT box

GTF2A1L

Synechocystis sp. PCC 6803

Transcription factor II B

Myosin-11

Rel homology domain

CUL4B

SEC61B

Antitermination

CUL4A

PPP2R2A

Sec61 alpha 1

MED26

PSMD10

Eukaryotic ribosome

Ars operon

EF-Ts

Tbf5 protein domain

DNA clamp

General transcription factor

PPP2R1A

PSMD7

Promoter (genetics)

Glucocorticoid receptor

PSMB3

TATA box

Regulator of G protein signaling

Mediator (coactivator)

Ubiquitin

PSMD5

SCF complex

Aminoglycoside

AI-10-49

G beta-gamma complex

NEDD8

S100A10

Phosphatidylinositol 4,5-bisphosphate

PSMA3

AAA proteins

Cellulase

Murine respirovirus

Epithelioid sarcoma

PSMB10

List of MeSH codes (D12.776)

NMDA receptor

core-binding factor subunit beta [Rattus norvegicus] - Protein - NCBI

Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores - PubMed

CBFB gene: MedlinePlus Genetics

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