Core Binding Factor alpha Subunits
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factors
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 1 Subunit
Core Binding Factor beta Subunit
Core Binding Factor Alpha 2 Subunit
Core Binding Factor Alpha 3 Subunit
Transcription Factor AP-2
Chromosomes, Human, Pair 16
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Leukemia, Myeloid, Acute
Oncogene Proteins, Fusion
Chromosomes, Human, Pair 21
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. (1/119)AML1 is one of the most frequently translocated genes in human leukemia. Here we demonstrate that acute myeloid leukemia-1 (AML-1) (Runx-1) represses transcription from a native promoter, p21(Waf1/Cip1). Unexpectedly, this repression did not require interactions with the Groucho co-repressor. To define the mechanism of repression, we asked whether other co-repressors could interact with AML-1. We demonstrate that AML-1 interacts with the mSin3 co-repressors. Moreover, endogenous AML-1 associated with endogenous mSin3A in mammalian cells. A deletion mutant of AML-1 that did not interact with mSin3A failed to repress transcription. The AML-1/mSin3 association suggests a mechanism of repression for the chromosomal translocation fusion proteins that disrupt AML-1. (+info)
Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. (2/119)Mice lacking the AML1/PEBP2alphaB/CBFa2 gene or PEBP2beta/CBFb gene exhibit a defect in definitive hematopoiesis and die in utero because of hemorrhage in the central nervous system. Hematopoiesis in the embryo is considered to be tightly associated with vascular development. Here we examined whether PEBP2/CBF plays any role in angiogenesis besides that in definitive hematopoiesis. We found that AML1/PEBP2alphaB/CBFa2, PEBP2alphaA/CBFa1, and PEBP2beta/CBFb were expressed in a murine endothelial cell line MSS31. The expression of these molecules as well as the DNA binding activity of PEBP2/CBF were augmented by angiogenic growth factors such as bFGF and VEGF. Moreover, the expression of PEBP2 alpha/CBFa protein in endothelial cells was confirmed at the site of angiogenesis in vivo. To further clarify the role of PEBP2/CBF in angiogenesis, we established permanent transfectants of PEBP2 beta-MYH11 gene, one that interacts with the runt domain of the alpha subunit and deregulates PEBP2/CBF in a dominant interfering manner. Proliferation, migration, and tube formation of the PEBP2 beta-MYH11 transfectants were significantly reduced in comparison with those activities of the mock transfectants. These results suggest that transcription factor PEBP2/CBF plays an important role in angiogenesis. (+info)
Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA. (3/119)Core binding factors (CBFs) play key roles in several developmental pathways and in human disease. CBFs consist of a DNA binding CBFalpha subunit and a non-DNA binding CBFbeta subunit that increases the affinity of CBFalpha for DNA. We performed sedimentation equilibrium analyses to unequivocally establish the stoichiometry of the CBFalpha:beta:DNA complex. Dissociation constants for all four equilibria involving the CBFalpha Runt domain, CBFbeta, and DNA were defined. Conformational changes associated with interactions between CBFalpha, CBFbeta, and DNA were monitored by nuclear magnetic resonance and circular dichroism spectroscopy. The data suggest that CBFbeta 'locks in' a high affinity DNA binding conformation of the CBFalpha Runt domain. (+info)
Runt domain factor (Runx)-dependent effects on CCAAT/ enhancer-binding protein delta expression and activity in osteoblasts. (4/119)Transcription factor CCAAT/enhancer-binding protein delta (C/EBPdelta) is normally associated with acute-phase gene expression. However, it is expressed constitutively in primary osteoblast cultures where it increases insulin-like growth factor I synthesis in a cAMP-dependent way. Here we show that the 3' proximal region of the C/EBPdelta gene promoter contains a binding sequence for Runt domain factor Runx2, which is essential for osteogenesis. This region of the C/EBPdelta promoter directed high reporter gene expression in osteoblasts, and specifically bound Runx2 in osteoblast-derived nuclear extract. C/EBPdelta gene promoter activity was reduced by mutating the Runx binding sequence or by co-transfecting with Runx2 antisense expression plasmid, and was enhanced by overexpression of Runx-2. Exposure to prostaglandin E(2) increased Runx-dependent gene transactivation independently of Runx2 binding to DNA. Runx2 bound directly to the carboxyl-terminal region of C/EBPdelta itself, and its ability to drive C/EBPdelta expression was suppressed when C/EBPdelta or its carboxyl-terminal fragment was increased by overexpression. Consistent effects also occurred on C/EBPdelta-dependent increases in gene expression driven by synthetic or insulin-like growth factor I gene promoter fragments. These interactions between Runx2 and C/EBPdelta, and their activation by prostaglandin E(2), provide new evidence for their importance during skeletal remodeling, inflammatory bone disease, or fracture repair. (+info)
Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha. (5/119)Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play critical roles in several developmental pathways, including hematopoiesis and bone development. Mutations in CBF genes are found in leukemias and bone disorders. CBFs consist of a DNA-binding CBFalpha subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBFbeta subunit. CBFalpha binds DNA in a sequence-specific manner, whereas CBFbeta enhances DNA binding by CBFalpha. Recent structural analyses of the DNA-binding Runt domain of CBFalpha and the CBFbeta subunit identified the heterodimerization surfaces on each subunit. Here we identify amino acids in CBFbeta that mediate binding to CBFalpha. We determine the energy contributed by each of these amino acids to heterodimerization and the importance of these residues for in vivo function. These data refine the structural analyses and further support the hypothesis that CBFbeta enhances DNA binding by inducing a conformational change in the Runt domain. (+info)
Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. (6/119)Hairy/Enhancer of split 1 (Hes1) is a mammalian transcriptional repressor that plays crucial roles in the regulation of several developmental processes, including neuronal differentiation. The aim of this study was to elucidate the molecular mechanisms that regulate the transcription repression activity of Hes1. It is shown here that Hes1 associates with the nuclear matrix, the ribonucleoprotein network of the nucleus that plays important roles in transcriptional regulation. Nuclear matrix binding is mediated by the same Hes1 C-terminal domain that is also required for transcriptional repression. This domain contains the WRPW motif that acts as a binding site for the transcriptional corepressor Groucho, which also localizes to the nuclear matrix. Both the nuclear matrix association and transcription repression activity of Hes1 are inhibited by deletion of the WRPW motif, indicating that Groucho acts as a transcriptional corepressor for Hes1. This corepressor role is not modulated by the Groucho-related gene product Grg5. In contrast, the Runt-related protein RUNX2, which localizes to the nuclear matrix and interacts with Groucho and Hes1, can inhibit both the Groucho.Hes1 interaction and the transcription repression ability of Hes1. Together, these observations suggest that transcriptional repression by Hes1 requires interactions with Groucho at the nuclear matrix and that RUNX proteins act as negative regulators of the repressive activity of Groucho.Hes1 complexes. (+info)
Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb. (7/119)We isolated zebrafish homologues of the Runt-related transcription factor gene family (Runx family), runxa and runxb, and analyzed their developmental expression patterns. The deduced amino acid sequence of Runxa was highly homologous to that of AML1 (also called CBFA2, PEBP2alphaB or Runx1), a critical regulator of mammalian hematopoiesis expressed in cells of the hematopoietic lineage as well as other tissues. During zebrafish development, the runxa gene was not expressed in hematopoietic tissues but in the olfactory placodes and cells attached to the otic vesicles. We identified three kinds of runxb transcripts, which encoded two types of proteins with different N-terminal regions. The Runxb proteins were highly similar to AML2 (CBFA3, PEBP2alphaC or Runx3). The expression sites of the shared region of runxb mRNAs during development were the trigeminal ganglions, dorsal neurons of the neural tube and the lateral line primordia. These findings show that expression patterns of the zebrafish Runx genes are distinct from that of the mammalian genes. (+info)
Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. (8/119)Mammalian CBFB encodes a transcription factor (CBF beta) that in combination with CBF alpha 2 binds to specific DNA sequences and regulates expression of a number of hematopoietic genes. CBFB is associated with human leukemias through a chromosome 16 inversion and is essential for definitive hematopoiesis during mouse embryo development. We have isolated a zebrafish cbfb complementary DNA (cDNA) clone from a zebrafish kidney cDNA library. This cbfb is highly homologous to human and mouse CBFB/Cbfb genes at both the DNA and protein level. In biochemical analyses, cbfbeta binds to human CBF alpha 2 and enhances its DNA binding. During zebrafish development, cbfb is expressed in the lateral plate mesoderm at tail bud stage and in the intermediate cell mass (ICM, the location of embryonic hematopoiesis) between the 21- to 26-somite stages. The cbfb is also expressed in Rohon-Beard cells, cranial nerve ganglia, hindbrain, retina, branchial arches, jaw, and fin buds. Expression of cbfb is decreased or absent in the ICM and Rohon-Beard cells in some hematopoietic mutants and is unaffected in others. We have also analyzed the expression of scl and gata-1 in the same hematopoietic mutants to ascertain the relative order of these transcription factors to cbfb in zebrafish hematopoiesis. Our results indicate that cbfb is expressed in early hematopoietic progenitors and that its expression pattern in the hematopoietic mutants is similar to that of scl. (Blood. 2000;96:4178-4184) (+info)
Runx-dependent expression of PKC is critical for cell survival in the by Carrie Dickey-Sims, Anthony J. Robertson et al.
BACKGROUND: Runx transcription factors play critical roles in the developmental control of cell fate and contribute variously as oncoproteins and tumor suppressors to leukemia and other cancers. To discover fundamental Runx functions in the cell biology of animal development, we have employed morpholino antisense-mediated knockdown of the sea urchin Runx protein SpRunt-1. Previously we showed that embryos depleted of SpRunt-1 arrest development at early gastrula stage and underexpress the conventional protein kinase C SpPKC1. RESULTS: We report here that SpRunt-1 deficiency leads to ectopic cell proliferation and extensive apoptosis. Suppression of the apoptosis by pharmacological inhibition of caspase-3 prevents the ectopic proliferation and rescues gastrulation, indicating that many of the overt defects obtained by knockdown of SpRunt-1 are secondary to the apoptosis. Inhibition or knockdown of SpPKC1 also causes apoptosis, while cell survival is rescued in SpRunt-1 morphant embryos coinjected with
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Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors | Development
There was an error published in Development 132, 4635-4644.. In Fig. 2, the incorrect image was shown in panel K. Owing to an error during figure assembly, Fig. 2K is a duplication of the wild-type embryo image shown in Fig. 5A. The corrected Fig. 2 appears below.. This error does not affect the conclusions of the paper. The authors apologise to readers for this mistake. ...
Transcriptional regulation in helper versus cytotoxic-lineage decision. - Semantic Scholar
The mechanism underlying the lineage decision made by CD4(+)CD8(+) double-positive (DP) thymocytes that give rise to two T lymphocyte subset with distinct functionalities, that is, helper and cytotoxic T cells, remains a major issue in immunology. The lineage decision process involves several phases and terminates when cells loose their developmental plasticity to become the alternate lineage. A detailed picture of the transcription factor network governing helper versus cytotoxic-lineage decision has recently emerged. Studies published only past year provided new insights into how the expression of ThPOK, a central transcription factor for helper T cell development, is regulated. It has now become evident that an antagonistic interplay between ThPOK and Runx transcription factor complexes plays an essential role in thwarting an alternate fate during the commitment process.
University of Birmingham research gateway
RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies. ...
JCI - Genetic regulation of the RUNX transcription factor family has antitumor effects
Cell proliferation. To assess cell proliferation, 1 × 105 cells of the indicated AML-derived cells were seeded in 6-well plates. For the tetracycline-inducible gene or shRNA expression, doxycycline was added to the culture at a final concentration of 3 μM. Trypan blue dye exclusion assays were performed every other day.. RT-qPCR. Total RNA was isolated with an RNeasy Mini Kit (Qiagen) and reverse transcribed with a ReverTra Ace kit (TOYOBO) to generate cDNA. RT-qPCR was carried out with a 7500 Real-Time PCR System (Applied Biosystems) according to the manufacturers instructions. The results were normalized to GAPDH levels. Relative expression levels were calculated using the 2-ΔΔCt method. Primers used for RT-qPCR are listed in Supplemental Table 3.. ChIP-qPCR. ChIP was performed using a SimpleChIP Plus Enzymatic Chromatin IP Kit (Cell Signaling Technology) according to the manufacturers instructions. In brief, cells were cross-linked in 1% formaldehyde in PBS for 10 minutes at room ...
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...
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User contributions for Solb - coreboot
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core binding factor alpha Summary Report | CureHunter
core binding factor alpha: core binding factor plays a key role in several development pathways and in human disease; has been sequenced
JCI - Genetic regulation of the RUNX transcription factor family has antitumor effects
Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of evidence suggests that it has pro-oncogenic properties in acute myeloid leukemia (AML). Here we have demonstrated that the antileukemic effect mediated by RUNX1 depletion is highly dependent on a functional p53-mediated cell death pathway. Increased expression of other RUNX family members, including RUNX2 and RUNX3, compensated for the antitumor effect elicited by RUNX1 silencing, and simultaneous attenuation of all RUNX family members as a cluster led to a much stronger antitumor effect relative to suppression of individual RUNX members. Switching off the RUNX cluster using alkylating agent-conjugated pyrrole-imidazole (PI) polyamides, which were designed to specifically bind to consensus RUNX-binding sequences, was highly effective against AML cells and against several poor-prognosis solid tumors in a xenograft mouse model of AML without ...
Modulation of Runx proteins by steroid hormone receptors :: University of Southern California Dissertations and Theses
Estrogen receptor α (ER α) and androgen receptor (AR) are master transcription factors in the breast and prostate, respectively. They are commonly known in development of sexual characteristics. However, both ERα and AR have been known to be involved in breast cancer (BCa) and prostate cancer (PCa) progression, respectively. The Runx family of transcription factors plays a role in hematopoiesis (Runx1), skeletogenesis (Runx2) and neurogenesis (Runx3). In addition, Runx proteins inhibit cell cycle progression, and have been assigned tumor suppressor roles in various contexts. Because both BCa and PCa cells metastasize to bone at high frequency, investigators have interrogated the possibility that they share characteristics with osteoblasts. Indeed, BCa and PCa cells were found to have osteomimetic properties, including expression of Runx2 and Runx2-target genes otherwise expressed by osteoblasts. Provoked by the reported physical interaction between AR and Runx2, we initiated a study to test ...
Runx Expression in Normal and Osteoarthritic Cartilage: Possible Funct by Kimberly T. LeBlanc
The Runx family of transcription factors supports cell fate determination, cell cycle regulation, global protein synthesis control, and genetic as well as epigenetic regulation of target genes. Runx1, which is essential for hematopoiesis; Runx2, which is required for osteoblast differentiation; and Runx3, which is involved in neurologic and gut development; are expressed in the growth plate during chondrocyte maturation, and in the chondrocytes of permanent cartilage structures. While Runx2 is known to control genes that contribute to chondrocyte hypertrophy, the functions of Runx1 and Runx3 during chondrogenesis and in cartilage tissue have been less well studied. The goals of this project were to characterize expression of Runx proteins in articular cartilage and differentiating chondrocytes and to determine the contribution of Runx1 to osteoarthritis (OA). Here, the expression pattern of Runx1 and Runx2 was characterized in normal bovine articular cartilage. Runx2 is expressed at higher levels in
Salivary Gland Development - Embryology
Runx1 mediates the development of the granular convoluted tubules in the submandibular glands The mouse granular convoluted tubules (GCTs), which are only located in the submandibular gland (SMG) are known to develop and maintain their structure in an androgen-dependent manner. We previously demonstrated that the GCTs are involuted by the epithelial deletion of core binding factor β (CBFβ), a transcription factor that physically interacts with any of the Runt-related transcription factor (RUNX) proteins (RUNX1, 2 and 3). This result clearly demonstrates that the Runx /Cbfb signaling pathway is indispensable in the development of the GCTs. However, it is not clear which of the RUNX proteins plays useful role in the development of the GCTs by activating the Runx /Cbfb signaling pathway. Past studies have revealed that the Runx /Cbfb signaling pathway plays important roles in various aspects of development and homeostatic events. Moreover, the Runx genes have different temporospatial ...
Truncated forms of RUNX3 unlike full length protein alter cell proliferation in a TGF-β context dependent manner
The Runt related transcription factors (RUNX) are recognized as key players in suppressing or promoting tumor growth. RUNX3, a member of this family, is known as a tumor suppressor in many types of cancers, although such a paradigm was challenged by some researchers. The TGF-β pathway governs major upstream signals to activate RUNX3. RUNX3 protein consists of several regions and domains. The Runt domain is a conserved DNA binding domain and is considered as the main part of RUNX proteins since. Herein, we compared the effects of Runt domains and full-Runx3 in cell viability by designing two constructs of Runx3, including N-terminal region and Runt domain. We investigated the effect of full-Runx3, N-t, and RD on growth inhibition in AGS, MCF-7, A549, and HEK293 cell lines which are different in TGF-β sensitivity, in the absence and presence of TGF-β. The full length RUNX3 did not notably inhibit growth of these cell lines while, the N-t and RD truncates showed different trends in these cell lines.
CBFB Gene - GeneCards | PEBB Protein | PEBB Antibody
Complete information for CBFB gene (Protein Coding), Core-Binding Factor Beta Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
HAENLIN/WALTZER - STEM CELLS IN VIVO (a French network)
Our team is interested in the mechanisms regulating blood cell fate during normal development or in pathological conditions such as leukemia or infection. In particular, we use Drosophila as a model system to investigate how blood cell progenitors are specified and how their maintenance is controlled. Notably, we aim at characterizing the different blood cell populations present in Drosophila at different stages of development and at defining the molecular signature and long term potential of Drosophila hematopoietic progenitors. An other aspect of our work focuses on the molecular mechanisms of action of conserved transcription factors implicated in hematopoiesis and leukemia, such as members of the GATA and RUNX families, and we try to define how they control blood cell programming and/or reprogramming ...
Core-binding factor, runt domain, alpha subunit 3 | definition of core-binding factor, runt domain, alpha subunit 3 by Medical...
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Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute...
Approximately 40% of patients affected by core binding factor (CBF) acute myeloid leukemia (AML) ultimately die from the disease. Few prognostic markers have been identified. In this study we reviewed 192 patients with core binding factor acute myeloid leukemia (AML), treated with curative intent (age, 15-79 years) in 11 Italian institutions. Overall, 10-year overall survival (OS), disease-free survival (DFS), and event-free survival were 63.9%, 54.8%, and 49.9%, respectively; patients with the t(8;21) and inv(16) chromosomal rearrangements exhibited significant differences at diagnosis. Despite similarly high complete remission (CR) rate, patients with inv(16) experienced superior DFS and a high chance of achieving a second CR, often leading to prolonged OS also after relapse. We found that a complex karyotype (ie, ≥4 cytogenetic anomalies) affected survival; the KIT D816 mutation predicted worse prognosis only in patients with the t(8;21) rearrangement, whereas FLT3 mutations had no ...
New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1 | Annals of the Rheumatic Diseases
Yano et al show that TD-198946 strongly induced in vitro chondrogenic differentiation of progenitors, as evidenced by a marked increase in the chondrogenic markers type II collagen and aggrecan; it did this without promoting hypertrophy (type X collagen and metalloprotease 13).8. This interesting balance between chondrogenesis and hypertrophic differentiation may be because TD-198946 exerts its effect through regulating the expression of Runx1, a known inducer of chondrogenic differentiation and a suppressor of the subsequent hypertrophy.10 The mammalian Runx protein family comprises three transcription factors: Runx1, Runx2 and Runx3. All Runx proteins are expressed during chondrogenesis; however, experimental results show a distinct role for Runx proteins in chondrogenesis and subsequent chondrocyte maturation.12 ,13 Runx1 is highly expressed during chondrogenesis in comparison with Runx2. Overall, the expression of Runx1 remained significantly higher than Runx2 expression during early limb ...
RUNX proteins in transcription factor networks that regulate T-cell lineage choice
Recent research has uncovered complex transcription factor networks that control the processes of T-cell development and differentiation. RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. In this Review, we examine the mechanisms …
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two ...
A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells [PeerJ]
Background. Members of the Runx gene family encode transcription factors that bind to DNA in a sequence-specific manner. Among the three Runx proteins, Runx2 comprises 607 amino acid (aa) residues, is expressed in bone, and plays crucial roles in osteoblast differentiation and bone development. We examined whether the Runx2 gene is also expressed in testes. Methods. Murine testes from 1-, 2-, 3-, 4-, and 10-week-old male mice of the C57BL/6J strain and W∕Wv strain were used throughout the study. Northern Blot Analyses were performed using extracts form the murine testes. Sequencing of cDNA clones and 5′-rapid amplification of cDNA ends were performed to determine the full length of the transcripts, which revealed that the testicular Runx2 comprises 106 aa residues coding novel protein. Generating an antiserum using the amino-terminal 15 aa of Runx2 (Met1 to Gly15) as an antigen, immunoblot analyses were performed to detect the predicted polypeptide of 106 aa residues with the initiating Met1. With
Biochemistry of Leukemia Virus Core Binding Factor - Nancy Speck
The Runx1-CBFbeta transcription factor is required for the emergence of all definitive hematopoietic cells. It is the earliest specific marker of sites from whi...
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML | JEM
Decreased Llgl1 expression has been previously shown to be associated with increased metastatic potential, malignant phenotype, or inferior survival in a variety of solid tumors (Ohali et al., 2004; Schimanski et al., 2005; Kuphal et al., 2006). Given that Llgl1 restrains self-renewal in HSCs and that leukemia is characterized by aberrant activation of self-renewal, we assessed for a role in human AML. First, we asked whether the gene expression signature revealed by genetic inactivation of Llgl1 (Llgl1−/− signature) in HSCs was associated with any genetic subtypes of primary AML. Indeed, clustering based on the Llgl1−/− signature (Fig. 4 B) grouped AML cases into subgroups significantly associated with cytogenetic abnormalities (Fig. 4, B and C). Especially core-binding factor leukemias (t(8;21) and inv(16)) or t(15;17) clustered into specific subgroups. Moreover, the Llgl1−/− signature was most strongly correlated with group 7 based on hierarchical clustering. This group contained ...
Rabbit Polyclonal Anti-RUNX3 Antibody, PA2112 | AMSBIO
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Dasatinib in Combination With Chemotherapy for Relapsed or Refractory Core Binding Factor Acute Myeloid Leukemia: A Phase I...
This study is examining the appropriate dose and side effects of dasatinib, when it is given with the standard of care chemotherapy for children and adolescents
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions<...
TY - JOUR. T1 - New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions. AU - Schiano, Concetta. AU - Soricelli, Andrea. AU - de Nigris, Filomena. AU - Napoli, Claudio. PY - 2018/12/20. Y1 - 2018/12/20. N2 - INTRODUCTION: High-resolution imaging is the gold standard to measure the functional and biological features of bone lesions. Imaging markers have allowed the characterization both of tumour heterogeneity and metabolic data. Besides, ongoing studies are evaluating a combined use of imaging markers, such as SUVs, MATV, TLG, ADC from PET and MRI techniques respectively, and several biomarkers spanning from chemokine immune-modulators, such as PD-1, RANK/RANKL, CXCR4/CXCL12 to transcription factors, such as TP53, RB1, MDM2, RUNX family, EZH2, YY1, MAD2. Osteoimmunology may improve diagnosis and prognosis leading to precision medicine in bone lesion treatment. Areas covered: We investigated modalities (molecular and imaging approach) useful to identify bone ...
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Patent US7919153 - Laminated structure, process of producing a liquid crystal cell substrate ... - Google Patents
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Dr Chen Hsung Edward Chew: Leukaemia Foundation
Among patients with good prognosis core binding factor AML, there is an overall survival rate of only 44%. To understand the genetic factors contributing to poor outcomes within this subgroup, Dr Chew is analysing bone marrow samples collected from 18 patients before and during treatment.. According to Dr Chew, multiple genetic abnormalities acquired during therapy are probably responsible for good prognosis core binding AML developing resistance to chemotherapy.. To help us predict who will respond poorly to therapy, were identifying the genetic mutations occurring in patients who relapse, he said. This information will allow us to tailor patient treatment accordingly. Currently a stem cell transplant is considered the definitive treatment and our findings will help clinicians decide if their patients AML will develop resistance and if a stem cell transplant is recommended.. Dr Chew is testing the usefulness of the genetic variations he identifies through an international ...
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RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding…
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Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801<...
TY - JOUR. T1 - Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia. T2 - CALGB 10801. AU - Marcucci, Guido. AU - Geyer, Susan. AU - Laumann, Kristina. AU - Zhao, Weiqiang. AU - Bucci, Donna. AU - Uy, Geoffrey L.. AU - Blum, William. AU - Eisfeld, Ann Kathrin. AU - Pardee, Timothy S.. AU - Wang, Eunice S.. AU - Stock, Wendy. AU - Kolitz, Jonathan E.. AU - Kohlschmidt, Jessica. AU - Mrózek, Krzysztof. AU - Bloomfield, Clara D.. AU - Stone, Richard M.. AU - Larson, Richard A.. N1 - Publisher Copyright: © 2020 by The American Society of Hematology. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/2/25. Y1 - 2020/2/25. N2 - Acutemyeloid leukemia (AML)witheither t(8;21)(q22;q22)or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%. Mutated (mut) or overexpressed KIT, a gene encoding a ...
Fluoride Action Network | Expression of core-binding factor a1 and osteocalcin in fluoride-treated fibroblasts and...
To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. Fibroblasts and osteoblasts were exposed to different concentrations of fluoride (0, 0.0001, 0.001, 0.1, 1.0, 10.0 and 20.0mg/L F-). By using RT-PCR and ELISA, the mRNA levels of Cbfa1 and OCN were measured at 48h, and the protein levels of Cbfa1 and OCN were measured at 2, 4, 24, 48 and 72h. The data demonstrated the following: (1) The Cbfa1 protein level in fluoride-treated fibroblasts clearly increased at 48h in the groups treated with 0.0001, 0.001, 0.1, 1.0 and 20.0mg/L F-. The Cbfa1 protein level of the group treated with 10mg/L F- at 72h was higher than that of the control group. The level of Cbfa1 mRNA in the fibroblasts ...
Dartmouth Digital Library Program
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and ...
RUNX3 expression in primary and metastatic pancreatic cancer | Journal of Clinical Pathology
The pathogenesis of PDAC involves genetic alterations, such as K-ras protooncogene mutations, mutations of the p53, p16, and Smad4 tumour suppressor genes, and other less common mutations.2 In addition, there are numerous epigenetic alterations, including altered expression of several growth factors and their receptors.3 For example, PDACs overexpress all TGFβ isoforms and their receptors, and overexpression of these ligands and receptors is often associated with shortened postoperative survival of patients with pancreatic cancer.14,15. The TGFβ pathway is carefully regulated, with Smad proteins as the key component in the signal transduction pathway. In addition, other regulators, such as transcription factors, which facilitate Smad binding to target promoters, may provide routes for feedback and crosstalk.16 For example, members of the CBFA (core binding factor A) family of transcription factors act both as targets and partners of activated Smads. This family, also termed the Runx family, ...
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Cells, Lead, Acute Myeloid Leukemia, Bone, Bone Marrow, Core-binding Factor, Cytogenetic, Cytogenetic Abnormalities, Disease, Leukemia, Marrow, Myeloid Leukemia, Patient, Patients, Protein Array, Proteins, Regression, Regression Analysis, Ability, Algorithm
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Gästbok | Veteran-OL
Veteranorientering i nordvästra Skåne är en samling härliga människor som orienterar tillsammans varannan onsdag. Arrangemanget går runt på veteraner i de olika klubbarna i nordvästra Skåne och det är alltid start klockan 09.00. Varmt välkommen att bli en av oss ...
HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia<...
TY - JOUR. T1 - HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia. AU - Richter, Lisa E.. AU - Wang, Yiqian. AU - Becker, Michelle E.. AU - Coburn, Rachel A.. AU - Williams, Jacob T.. AU - Amador, Catalina. AU - Hyde, R. Katherine. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv (16)], which generates a fusion between the genes for core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11), forming the oncogene CBFB-MYH11. The expressed protein, CBFb-SMMHC, forms a heterodimer with the key hematopoietic transcription factor RUNX1. Although CBFb-SMMHC was previously thought to dominantly repress RUNX1, recent work suggests that CBFb-SMMHC functions together with RUNX1 to activate transcription of specific target ...
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the regulatory mechanisms underlying RUNX1 expression in neuroblastoma (NB), a highly malignant tumor in childhood, remain largely unclear. In this study, we aimed to assess the role of RUNX1 in NB and to reveal the underlying mechanisms that may contribute to finding a potential therapeutics strategy against NB. Growth, invasion, metastasis and angiogenesis were assessed using Cell Counting Kit-8 (CCK-8) immunocytochemistry, and studies involving soft agar, cell invasion, tube formation and whole animals. The levels of expression were measured using real-time quantitative PCR for RNA, Western blot and immunostaining analyses for proteins. Luciferase reporter and chromatin immunoprecipitation assays indicated that RUNX1 directly binds within the BIRC5, CSF2RB and NFKBIA promoter regions to facilitate
WikiGenes - RUNX1 - runt-related transcription factor 1
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Theory of Nematic-smectic phase separation in thin twisted liquid crystal cells<...
TY - JOUR. T1 - Theory of Nematic-smectic phase separation in thin twisted liquid crystal cells. AU - Osipov, M.A.. AU - Sambles, J.R.. AU - Ruan, L.. PY - 2003/7/7. Y1 - 2003/7/7. N2 - Recently it has been shown experimentally by the authors that a highly twisted thin nematic cell at low temperatures can separate into a smectic A region in the middle of the cell surrounded by twisted nematic layers at the boundaries. In this case the twist is expelled into the nematic layers and the nematic-smectic A transition temperature is strongly depressed. We present a thermodynamic theory of such a phase transition in a twisted nematic cell, taking into account that the smectic A slab inside the nematic cell can be stable only if the decrease of free energy in the smectic region overcomes the increase in distortion energy of the twist deformation in the nematic layers plus the energy of the nematic-smectic A interface. In such a system the equilibrium thickness of the smectic A slab corresponds to the ...
anti-RUNX1 antibody | GeneTex
RUNX1 antibody (runt-related transcription factor 1) for WB. Anti-RUNX1 pAb (GTX11903) is tested in Human, Mouse samples. 100% Ab-Assurance.
anti-RUNX1 antibody | GeneTex
RUNX1 antibody (runt-related transcription factor 1) for ICC/IF, WB. Anti-RUNX1 pAb (GTX129100) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer<...
TY - JOUR. T1 - Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer. AU - Horiguchi, Shigeru. AU - Shiraha, Hidenori. AU - Nagahara, Teruya. AU - Kataoka, Jyunnro. AU - Iwamuro, Masaya. AU - Matsubara, Minoru. AU - Nishina, Shinichi. AU - Kato, Hironari. AU - Takaki, Akinobu. AU - Nouso, Kazuhiro. AU - Tanaka, Takehiro. AU - Ichimura, Koichi. AU - Yagi, Takahito. AU - Yamamoto, Kazuhide. PY - 2013/8. Y1 - 2013/8. N2 - Background & Aim: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor gene that is expressed in gastric and other cancers including pancreatic cancer. However, the precise function of RUNX3 in pancreatic cancer has not been fully elucidated. In this study, we aimed to determine the effect of decreased RUNX3 expression in pancreatic cancer. Methods: This study included 36 patients with primary pancreatic cancer, who had undergone pancreaticoduodenectomy. All patients were treated with 1000mg/m2 gemcitabine after the surgery. ...
US6801183B2 - Temperature compensation for liquid crystal cell optical devices - Google Patents
A temperature compensation circuit arrangement for liquid crystal cells in optical devices is presented. In an optical device, a liquid crystal cell typically manipulates the optical signals according to an output optical property, such as attenuation, responsive to an AC voltage source electrical signal. A feedback circuit arrangement is connected to the liquid crystal cell and controls the current through the liquid crystal cell with respect to temperature by a predetermined control equations for the output optical property so that the device manipulates the optical signals independently of temperature. The current follows the control equations, which are empirically determined with respect to temperature for one equation.
Dartmouth Digital Library Program
Core-binding factors (CBFs) are a small family of transcription factors that play important roles in several developmental processes and in human disease. CBFs consist of CBFα (Runx1, Runx2, or Runx3) and CBFβ. The CBFα subunit binds DNA in a ...
Bob Ohgami, MD, PhD | UCSF Helen Diller Family Comprehensive Cancer Center
Ustun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, Broesby-Olsen S, Ohgami R, Kim Y, Sperr W, Vestergaard H, Chen D, Kluin PM, Dolan M, Mrózek K, Czuchlewski D, Horny HP, George TI, Kristensen TK, Ku NK, Yi CA, Møller MB, Marcucci G, Baughn L, Schiefer AI, Hilberink JR, Pullarkat V, Shanley R, Kohlschmidt J, Coulombe J, Salhotra A, Soma L, Cho C, Linden MA, Akin C, Gotlib J, Hoermann G, Hornick J, Nakamura R, Deeg J, Bloomfield CD, Weisdorf D, Litzow MR, Valent P, Huls G, Perales MA, Borthakur G Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit). View on PubMed ...
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"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... Transcription factors, All stub articles, Human chromosome 20 gene stubs). ...
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. The Runx2 DNA-binding activity is correlated with ...
... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β′ The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...
... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ... In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has ...
... or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. RUNX1 is a ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 ... The conserved region contains four alpha helices and three loops arranged as in histone H3. TAF11 has been shown to interact ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ...
... it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and ... Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...
These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... The first domain (A1) contains 20 amino acids that forms an alpha helix that appears significant in its interactions with NF-YB ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...
... which include two alphas, a beta, and a beta prime (α, α, β, and β'). A fifth subunit, sigma (called the σ-factor), is only ... The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ...
This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...
"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... Binding of IL-12 to IL-12R, which is composed of two different subunits (IL12Rβ1 and IL12Rβ2), leads to the interaction of ... "Increased sensitivity to interferon-alpha in psoriatic T cells". The Journal of Investigative Dermatology. 125 (5): 936-44. doi ... association with regulatory factors; 3. central DNA-binding domain - binding to the enhancer region of IFN-γ activated sequence ...
Selective factor 1 is composed of the TATA-binding protein and three TAF (TATA box-binding protein-associated factor) subunits ... It contains two short alpha helices and a long central alpha helix. TAF1 (TAFII250) TAF2 (CIF150) TAF3 (TAFII140) TAF4 ( ... for example the downstream promoter element or gene-specific core promoter sequence Due to such interactions, they contribute ... The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a ...
This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several ... The protein complex that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to ... "Induced alpha helix in the VP16 activation domain upon binding to a human TAF". Science. 277 (5330): 1310-3. doi:10.1126/ ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ...
One species that looked at is Drosophila, and in the subunits of the Drosophila transcription initiation factor has specific ... conserved motif found near the C-terminus in every core histone sequence in a histone octamer responsible for the binding of ... The histone fold averages about 70 amino acids and consists of three alpha helices connected by two short, unstructured loops. ... Also the histone fold was first found in TATA box-binding protein-associated factors, which is a main component in ...
This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...
In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... "Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases". Structure. 17 (7): 981-9. ... The catalytic domain consists of a double-stranded β-helix core that is stabilized by three α-helices packed along the major β- ... X-ray crystallography and NMR spectroscopy showed that both peptides bind to the same binding site on PHD2, in a cleft on the ...
The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ...
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a ... This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and ... TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription ...
Sec61 alpha 1
Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...
"The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative ... which interacts with the seven-membered alpha ring of 20S core particle and establishes an asymmetric interface between the 19S ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599-606. doi:10.1006/jmbi. ... "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655-66. ... The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of ...
November 1993). "A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase". ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ...
This contains a core of two compact domains with each having five alpha helices. The first five-helix bundle is a conserved ... Viral cyclin D binds human Cdk6 and inhibits Rb by phosphorylating it, resulting in free transcription factors which result in ... A simplification in yeast is that all cyclins bind to the same Cdc subunit, the Cdc28. Cyclins in yeast are controlled by ... A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast ...
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
Tbf5 protein domain
... general transcription factor 2H subunit 5) is also known as the TTD group A (TTDA) subunit (and as Tfb5). The TTDA subunit is ... and part of a six-subunit complex of Rad3, Tfb1, Tfb2, Tfb4, Tfb5, and Ssl1 (referred to as core) In humans, the function of ... TTDA is present both bound to TFIIH, and as a free fraction that shuffles between the cytoplasm and nucleus; induction of NER- ... These proteins have a structural motif consisting of a 2-layer sandwich structure with an alpha/beta plait topology. ...
EIF-W2 protein domain
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... The W2 domain has a globular fold and is exclusively composed out of alpha-helices. ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ...
List of MeSH codes (D12.776.930)
... core binding factor alpha 1 subunit MeSH D12.776.9188.8.131.52 - core binding factor alpha 2 subunit MeSH D12.776.930.155. ... 200.300 - core binding factor alpha 3 subunit MeSH D12.776.930.316.750.750 - maf transcription factors, small MeSH D12.776. ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.930.323. ... CCAAT-binding factor MeSH D12.776.9184.108.40.2060 - CCAAT-enhancer-binding protein-alpha MeSH D12.776.9220.127.116.110 - CCAAT- ...
It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... "Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the ... The role of alpha and beta isoforms of the glucocorticoid receptor]". Archivos de Bronconeumologia. 38 (9): 436-440. doi: ... hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors ...
Alongside alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i "Entrez ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...
2002). "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV ... Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ... 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97 ... 2002). "The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 ...
... encoding protein Polyamine-modulated factor 1-binding protein 1 POLR3K: encoding enzyme DNA-directed RNA polymerase III subunit ... encoding protein VPS35 Endosomal Protein Sorting Factor Like WFDC1: encoding protein WAP four-disulfide core domain protein 1 ... alpha pseudogene 1 HBHR, ATR1: Alpha-thalassemia/mental retardation syndrome, type 1 HIRIP3: encoding protein HIRA-interacting ... encoding protein SHC SH2 domain-binding protein 1 SLZ1: encoding protein SLX1 structure-specific endonuclease subunit homolog B ...
Regulator of G protein signaling
... with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit ... is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11916-20. doi: ... a pheromone desensitization factor in Saccharomyces cerevisiae". Mol Cell Biol. 15 (7): 3635-43. doi:10.1128/MCB.15.7.3635. PMC ... G protein gamma subunit-like) for binding G protein beta subunits (InterPro: IPR001770 Those RGS proteins that contain GGL ...
Cadherin-catenin complex in learning and memory
Expression of lymphoid enhancer-binding factor 1 (LEF-1) triggers the translocation of β-catenin to the nucleus, where it ... Protocadherin-alpha and protocadherin-gamma interact to form a protein complex that enhances the surface expression of each ... Davis, MA; Ireton, RC; Reynolds, AB (2003). "A core Function for p120-catenin in cadherin turnover". J. Cell Biol. 163 (3): 525 ... impaired the stabilization of GluR2 and GluR3 AMPAR subunits, respectively, at the plasma membrane. Co-localization of p120ctn ...
These core histones are rich in lysine and arginine residues. The carboxyl (C) terminal end of these histones contribute to ... It results in good optimization and is used in vivo to reveal DNA-protein binding occurring in cells. ChIP-Seq can be used to ... H4K8ac indicates acetylation of lysine 8 on histone H4 protein subunit: The genomic DNA of eukaryotic cells is wrapped around ... Maruta H, Greer K, Rosenbaum JL (1986). "The acetylation of alpha-tubulin and its relationship to the assembly and disassembly ...
p53 is unique as a transcription factor in that it can recognize and bind response elements (RE) in many different environments ... One of the two molecules of this complex is multimeric alpha lactalbumin (MAL) (Figure 3), which was first discovered during a ... "Identification of a Unique Core Domain of Par-4 Sufficient for Selective Apoptosis Induction in Cancer Cells". Molecular and ... that the mechanisms behind the function of E4orf4 is closely associated with several other proteins including the B55 subunit ...
Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex ... Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (March 1999). "A novel ubiquitination factor, E4, is involved in ... This is a barrel-shape structure comprising a central proteolytic core made of four ring structures, flanked by two cylinders ... alpha} via the N-terminal pathway". The Journal of Biological Chemistry. 285 (51): 40192-200. doi:10.1074/jbc.M110.131615. PMC ...
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... Deveraux Q, Ustrell V, Pickart C, Rechsteiner M (1994). "A 26 S protease subunit that binds ubiquitin conjugates". J. Biol. ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
... but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and ... Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity. The ... while GTP exchange is catalyzed by guanine nucleotide exchange factors (GEFs). Activation of a GEF typically activates its ... A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ...
Synaptobrevin binds the α-helix near the C-terminus of SNAP-25, while syntaxin-1 binds the α-helix near the N-terminus. ... The core symptoms comprise intellectual disability ranging between mild to profound and early-onset seizures mostly occurring ... Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a ... Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein ...
Leiser SC, Bowlby MR, Comery TA, Dunlop J (June 2009). "A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is ... FABP7, coding the Fatty acid-binding protein 7 (brain), one SNP of which was associated with schizophrenia in one 2008 study, ... Alderson RM, Rapport MD, Hudec KL, Sarver DE, Kofler MJ (May 2010). "Competing core processes in attention-deficit/ ... CHRNA7, coding the neuronal nicotinic acetylcholine receptor alpha7 subunit. alpha7-containing receptors are known to improve ...
The subunit Rpn12 incorporated into 19S regulatory particle when 19S lid and base bind together. Among these lid subunits, ... as well as to cause conformational changes to the alpha subunit C-terminals that form the substate entrance of the 20S complex ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... The 26S proteasome complex usually consists of a 20S core particle (CP, or 20S proteasome) and one or two 19S regulatory ...
G beta-gamma complex
Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... The Gβγ subunit has been shown to activate a Rho guanine nucleotide exchange factor (RhoGef) gene PLEKHG2 which is upregulated ... N terminus helical domains of the two subunits form a coiled coil with one another that typically extends away from the core of ... The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ...
Homeobox protein MSX-1
"Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ... MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh ... encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core ... "Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ...
Akiba S, Hatazawa R, Ono K, Hayama M, Matsui H, Sato T (Nov 2000). "Transforming growth factor-alpha stimulates prostaglandin ... Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... Munz B, Gerke V, Gillitzer R, Werner S (Mar 1997). "Differential expression of the calpactin I subunits annexin II and p11 in ... by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. The ...
... which is initiated by ligands binding to G protein-coupled receptors activating the Gq alpha subunit. PtdIns(4,5)P2 is a ... 2004). "CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP 2 binding protein". Neuron. 43 (4): 551-562. ... Some of the factors involved in PIP2 regulation are: Lipid kinases, Lipid Phosphatase Lipid Transfer Proteins Growth Factors, ... PIP2 has been shown to recruit G protein-coupled receptor kinase 2 (GRK2) to the membrane by binding to the large lobe of GRK2 ...
In this process, Cables 1 mechanistically interferes the proteasome subunit alpha type-3 (PMSA3) hereby binding to p21 to ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ...
In the hexameric configuration, the ATP-binding site is positioned at the interface between the subunits. Upon ATP binding and ... an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold) and a C-terminal alpha-helical domain. ... AAA proteins are divided into seven basic clades, based on secondary structure elements included within or near the core AAA ... "Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP". Nat. Struct. ...
... the alpha helix). Linus Pauling was the first to identify the 3.6 amino acids per helix turn ratio of the alpha helix. Crick ... It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... one factor being that the new college did not have a chapel. Some time later a large donation was made to establish a chapel ...
... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity. Multidomain cellulases are ... McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-β-D-glucanase". ... construction of the catalytic core, expression, and X-ray structure at 1.75 Å resolution". Biochemistry. 36 (51): 16032-9. doi: ...
... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... The SeV virion also contains the nucleocapsid core, which is composed of the genomic RNA, the nucleocapsid protein (NP), the ... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ...
Since 56Ni (14 alpha particles) is easily produced from lighter nuclei in the alpha process in nuclear reactions in supernovae ... As such, iron is the most abundant element in the core of red giants, and is the most abundant metal in iron meteorites and in ... Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... The ensuing availability of inexpensive iron was one of the factors leading to the Industrial Revolution. Toward the end of the ...
Proteasome subunit beta type-10 is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and ... that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...
RUNX1T1 gene: MedlinePlus Genetics
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related ... The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). As part of CBF ... Core binding factor acute myeloid leukemia. A rearrangement (translocation) of genetic material involving the RUNX1T1 gene is ... Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2): ...
Characterization of the Platelet Phenotype Caused by a Germline RUNX1 Variant in a CRISPR/Cas9-Generated Murine Model
Cancers | Free Full-Text | Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across...
... core-binding factor subunit alpha 2 (CBFA2) is a tumor suppressor. Mocetinostat (MGCD0103) or Sorafenib NCT00217646 **. ... PIK3R1 (PI3K regulatory subunit alpha). Copanlisib. NCT02369016 **. PTCH1. PTCH1 (Protein patched homolog 1) is a receptor for ... CSF1 (colony stimulating factor 1) regulates differentiation and survival. Chiauranib NCT03074825 **. CXCR4. CXCR4 (C-X-C ... FGFR3 (fibroblast growth factor receptor 3) promotes cell cycle via activation of RAS/MAPK/AKT pathway. Lenvatinib, Pazopanib, ...
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in...
Core Binding Factor Alpha 1 Subunit 100% * DNA 8% * Gene Expression 8% ... Dive into the research topics of Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast ... Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in ...
ZFIN Publication: Bresciani et al., 2014
骨科學科 - 研究成果 - 臺北醫學大學
Core Binding Factor Alpha 1 Subunit 58% 16 引文 斯高帕斯（Scopus） ... Usage of growth factors in acute muscle injuries. Chen, C. H., Lee, C. H. & Chang, C. H., 1月 1 2015, Sports Injuries: ... Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center. Lee, C. ...
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. - Nuffield...
Core Binding Factor alpha Subunits Entry term(s). Acute Myeloid Leukemia Proteins Core Binding Factor alpha Proteins PEBP2A ... A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. ... A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. ... Core Binding Factor alpha Subunits Descriptor Spanish: Subunidades alfa del Factor de Unión al Sitio Principal Spanish from ...
IMP: Integrative Multi-species Prediction
core-binding factor, runt domain, alpha subunit 2; translocated to, 3. 0.039. ... hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor). 0.045. ... transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha). 0.060. ... transcription factor AP-2 beta (activating enhancer binding protein 2 beta). 0.015. ...
Ke Yuan, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
RCSB PDB - 6I7T: eIF2B:eIF2 complex
Translation initiation factor eIF-2B subunit alpha. A,. H [auth B]. 305. Saccharomyces cerevisiae. Mutation(s): 0 Gene Names: ... eIF2 undergoes large rearrangements to promote binding of eIF2α to the regulatory core of eIF2B comprised of the eIF2B alpha, ... Eukaryotic translation initiation factor 2 subunit alpha. K,. N [auth L]. 304. Saccharomyces cerevisiae. Mutation(s): 0 Gene ... Translation initiation factor eIF-2B subunit beta. D [auth E],. I [auth F]. 381. Saccharomyces cerevisiae. Mutation(s): 0 Gene ...
Runt-Related Transcription Factor 1 (RUNX1)). Core binding factor (CBF) is a heterodimeric transcription factor that binds to ... the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is ... runt-related transcription factor 1 (runx1) Anticorps. runt related transcription factor 1 L homeolog (runx1.L) Anticorps. runt ... runt-related transcription factor (runt) Anticorps. runt related transcription factor 1 (Runx1) Anticorps. runt related ...
Bone lengthening. Medical search
Core Binding Factor Alpha 1 Subunit. A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core ... PhosphatasePhosphorusReceptor Activator of Nuclear Factor-kappa BBiocompatible MaterialsCore Binding Factor Alpha 1 Subunit ... Transforming Growth Factor beta. A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in ... binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic ...
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. | [email protected]
Core Binding Factor Alpha 1 Subunit * Gene Expression Regulation, Neoplastic * Liver Neoplasms ... Gel-shift assays sublocalized two cis-regulatory regions, nt -101 to -123 and nt -121 to -145, which specifically bind CT26 ... Functional relevance was demonstrated through mutations in the Ets-1 and Runx2 consensus binding sites resulting in ,60% ... Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. ...
Phillip Tai's co-authors | Profiles RNS
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. - Radcliffe Department of Medicine
Furthermore, binding of an Scl-Lmo2-Gata2 complex was demonstrated to occur on the regions flanking the conserved E-boxes of ... Bioinformatics analysis resulted in the identification of 9 candidate Scl target transcription factor genes, including Runx1 ... the precise mechanisms by which these factors interact to form transcriptional networks, as well as the identity of the genes ... Transcription factors such as Scl/Tal1, Lmo2, and Runx1 are essential for the development of hematopoietic stem cells (HSCs). ...
Pesquisa | Prevenção e Controle de Câncer
Runt Related Transcription Factor 1 (RUNX1) and Core-Binding Factor Runt Domain Alpha Subunit 2 Translocated To 3 (CBFA2T3, ... Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among ... FOXA1 is a pioneer factor that binds to enhancer regions that are enriched in H3K4 mono- and dimethylation (H3K4me1 and H3K4me2 ... Our Illumina-based ChIP-exo provides high resolution mapping of transcription factor binding sites. ...
The Role of Runx1 in Embryonic Blood Cell Formation. - Oxford Stem Cell Institute
Shinobu Matsuura | Profiles RNS
Core Binding Factor Alpha 2 Subunit. *Primary Myelofibrosis. See all (246) concept(s) ... Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med ... Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc ... Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization. Blood Cancer J. 2016 ...
SMART: PH domain annotation
Crystal structure of full length centaurin alpha-1. 3fm8. Crystal structure of full length centaurin alpha-1 bound with the FHA ... The core of the molecule is an antiparallel beta-sheet consisting of seven strands. The C terminus is folded into a long alpha- ... The PH domain in beta-adrenergic receptor kinase may be involved in binding to the beta gamma subunits of a trimeric G-protein ... A family of NMR solution structures of the growth factor receptor-bound protein 2 (Grb2) SH2 domain has been determined by ...
Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related...
Core Binding Factor Alpha 3 Subunit, Core Binding Factor beta Subunit, Evolution, Molecular, Fish Proteins, Gene Expression ... was shown to negatively regulate BMP2 transcription and combination with the core binding factor β (CBFβ) further reduced ... Although to a lesser extent, myocyte enhancer factor 2C (MEF2C) had also a negative effect on the regulation of BMP2 gene ... Animals, Binding Sites, Bone and Bones, Bone Morphogenetic Protein 2, Cartilage, ...
Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal...
Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; *Gene Expression Regulation, ... developmental association of the AML/CBF alpha/PEBP2 alpha-related transcription factor-NMP-2 with the nuclear matrix ... Transcription Factor AP-2; Transcription Factors. Life Sciences. Medicine and Health Sciences ... NGF, which can bind to endogenous p75, did not induce differentiation but enhanced the EGF-induced response, leading to ...
Structure-based design of mimetics for granulocyte-macrophage colony stimulating factor (GM-CSF)<...
The human GM-CSF core structure consists of a four α-helix bundle, and GM-CSF activity is controlled by its binding to a two- ... subunit receptor. A number of residues located on the B and C helices of GM-CSF are postulated to interact with the alpha chain ... The human GM-CSF core structure consists of a four α-helix bundle, and GM-CSF activity is controlled by its binding to a two- ... The human GM-CSF core structure consists of a four α-helix bundle, and GM-CSF activity is controlled by its binding to a two- ...
ISMARA results: SOX5.p2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2 chr3_-_150993299 0.690 NM_001144960. C3orf16 chromosome 3 ... fibroblast growth factor receptor 2 chr1_-_51660328 0.394 NM_001159969. EPS15 epidermal growth factor receptor pathway ... RNA binding motif protein 47 chr11_+_56224436 0.838 NM_001005213. NM_001013358. OR9G1 OR9G9 olfactory receptor, family 9, ... transcription factor Dp-2 (E2F dimerization partner 2) chr5_+_147562531 0.510 NM_001195290. NM_205841. SPINK6 serine peptidase ...
Search | Global Index Medicus
Animals , Calcium Carbonate/metabolism , Core Binding Factor Alpha 1 Subunit/metabolism , Exosomes/metabolism , Humans , Male ... By using the drug metabolizing enzyme inhibitors, the effects of metabolic factors on potential liver injury induced by the ... Target genes of differential miRNA were mainly involved in membrane composition, mainly played molecular functions binding to ... which provides a reference to the evaluation of susceptible factors and drug incompatibility research of Polygonum multiflorum. ...
Motif 1 Binding Protein
A sequence-specific core promoter-binding transcription factor recruits TRF2 to coordinately transcribe ribosomal protein genes ... GFZF binds to the promoters of three (msl-1, msl-2, and mle) out of five subunits that comprise the male-specific lethal (MSL) ... Using either the alpha fragment of LacZ as a control or full-length M1BP fused to Mal, it was determined that GFZF interacts ... A total of 3,013 genes are bound by M1BP, while 1,885 are bound by GFZF. Furthermore, both factors are bound almost exclusively ...
Gene P04584 | Protein gag-pol - Mutations | canSAR.ai
Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the pro ... The core is disassembled soon after virion entry (By similarity). Host restriction factors such as TRIM5-alpha or TRIMCyp bind ... Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. ... Binds to RNA., Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. ...
SCOPe 2.01: Class a: All alpha proteins
multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif ... core: 5 helices; one helix is surrounded by the others. *. a.150: Anti-sigma factor AsiA  (1 superfamily). core: 5 ... a.118: alpha-alpha superhelix  (24 superfamilies). multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix ... core: 3 helices; folded leaf, opened. *. a.4: DNA/RNA-binding 3-helical bundle  (14 superfamilies). core: 3-helices; ...
SMART: eIF5C domain annotation
Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... Three conserved motifs, one of which appears to be a variant of the phosphate-binding site (P-loop) and another that may be ... The W2 domain has a globular fold and is exclusively composed out of alpha- helices [ (PUBMED:14681227) (PUBMED:16616930) ( ...
Browse ORF cDNA clones by species Pan troglodytes, letter g, page 1
G protein subunit alpha i3. protein-coding. GPBP1L1. GC-rich promoter binding protein 1 like 1. protein-coding. ... general transcription factor IIH subunit 1. protein-coding. GPRASP2. G protein-coupled receptor associated sorting protein 2. ... glucosaminyl (N-acetyl) transferase 1, core 2. protein-coding. GNAI1. G protein subunit alpha i1. protein-coding. ... gamma-aminobutyric acid type A receptor alpha1 subunit. protein-coding. GPR101. G protein-coupled receptor 101. protein-coding ...
ProteinPolymeraseProteinsRUNX1Heterodimeric transcriptionRegulatorySynthaseInitiation factorMembraneMediatorEpsilonRunt domainPutativeTranscription FactorsTRNAReceptorsGenesGeneSaccharomycesMoleculePromoterComplexEIF2BNucleotideCytochromeComplexesDomainRNAsCTCFAssaysBetaResidues involvedTranslationRegulationCohesinTherapeuticMyogenin
- The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). (medlineplus.gov)
- The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. (anticorps-enligne.fr)
- Competition with unlabeled mutant oligonucleotides revealed that the regions nt -115 to -118 and nt -129 to -134 were essential for protein binding. (duke.edu)
- Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. (duke.edu)
- CONCLUSIONS: Altogether, our findings reveal a novel and important activation loop between the transcription regulator CBFA2T3 and the transcription factor RUNX1 that promotes BCP-ALL proliferation, supporting the development of an innovative therapeutic approach based on the NHR2 subdomain of CBFA2T3 protein. (bvsalud.org)
- Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
- Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
- Bone morphogenetic protein (BMP) 2 belongs to the transforming growth factor β (TGFβ) superfamily of cytokines and growth factors. (ualg.pt)
- Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
- Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). (cansar.ai)
- The core is constituted by capsid protein hexamer subunits. (cansar.ai)
- Eukaryotic translation initiation factor 5 (eIF-5), a GTPase-activating protein (GAP) specific for eIF2. (embl-heidelberg.de)
- The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions. (embl-heidelberg.de)
- Similar to eIF2s1, eIF4E can be phosphorylated by binding proteins, and these are seen to have differing levels of gene expression with various ligand stimulations, allowing for large variability in protein synthesis. (escholarship.org)
- This interaction involves a specific region of RPB3 protein that is not homologous to the prokaryotic a subunit. (elsevier.com)
- LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
- protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
- gametogenetin binding protein 2 [So. (gsea-msigdb.org)
- RNA-binding protein;RNA degradosome binding protein [Ensembl]. (ntu.edu.sg)
- The inhibitory effect of resveratrol on poxviruses is independent of VACV N1 protein, a potential resveratrol binding target. (researchgate.net)
- While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors to communicate with essentially every organ system in the body. (diabetesjournals.org)
- Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)
- Which of the following is NOT a component of the bacterial RNA polymerase core enzyme? (paperforpay.com)
- In the experiment to study the effect of temperature change on RNA polymerase binding to DNA, we found that as the temperature is _______, the binding of RNA polymerase to DNA decreases. (paperforpay.com)
- Because _______ temperatures promote DNA melting and encourage RNA polymerase binding. (paperforpay.com)
- The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (elsevier.com)
- RNA polymerase II core subunit 3 (RPB3) is an a-like core subunit of RNA polymerase II (pol II). (elsevier.com)
- Dive into the research topics of 'The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin. (elsevier.com)
- It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. (medlineplus.gov)
- Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. (medlineplus.gov)
- Gel-shift assays sublocalized two cis-regulatory regions, nt -101 to -123 and nt -121 to -145, which specifically bind CT26 nuclear proteins. (duke.edu)
- Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (lookformedical.com)
- The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
- Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
- Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
- Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
- Many DNA-binding proteins show co-localization in ChIP-Seq data without presence of the corresponding DNA motifs. (sdbonline.org)
- Computer-assisted analysis of amino acid sequences using methods for database screening with individual sequences and with multiple alignment blocks reveals a complex multidomain organization of yeast proteins GCD6 and GCD1, and mammalian homolog of GCD6-subunits of the eukaryotic translation initiation factor eIF-2B involved in GDP/GTP exchange on eIF-2. (embl-heidelberg.de)
- It is shown that these proteins contain a putative nucleotide-binding domain related to a variety of nucleotidyltransferases, most of which are involved in nucleoside diphosphate-sugar formation in bacteria. (embl-heidelberg.de)
- In proteins the subunits of lysosomes to proteins represents the most critical regulating body. (familie-vos.de)
- BMs also harbor matricellular proteins, growth factors, and proteases ( 1 ). (science.org)
- Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
- A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)
- In addition, the CH domain occurs also in a number of proteins not known to bind actin, a notable example being the vav protooncogene. (embl.de)
- Gelation factor (ABP120) is one of the principal actin-cross-linking proteins of Dictyostelium discoideum. (embl.de)
- Levels of integrin α IIb β 3 activation, fibrinogen binding, and aggregation were significantly lower in platelets from RUNX1 L43S/L43S and RUNX1 WT/L43S using phorbol 12-myristate 13-acetate (PMA), adenosine diphosphate (ADP), and high thrombin doses. (nih.gov)
- CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. (zfin.org)
- Runt Related Transcription Factor 1 (RUNX1) and Core-Binding Factor Runt Domain Alpha Subunit 2 Translocated To 3 (CBFA2T3, ETO2, MTG16) are master regulators of hematopoiesis and are implicated in leukemia. (bvsalud.org)
- By ChIP-Seq in BCP-ALL patients' cells and cell lines, we found that RUNX1 is recruited on its promoter and on an enhancer of CBFA2T3 located - 2 kb upstream CBFA2T3 promoter and that, subsequently, the transcription factor RUNX1 drives both RUNX1 and CBFA2T3 expression. (bvsalud.org)
- We demonstrated that, mechanistically, RUNX1 and CBFA2T3 can be part of the same complex allowing CBFA2T3 to strongly potentiate the activity of the transcription factor RUNX1. (bvsalud.org)
- Transcription factors such as Scl/Tal1, Lmo2, and Runx1 are essential for the development of hematopoietic stem cells (HSCs). (ox.ac.uk)
- Bioinformatics analysis resulted in the identification of 9 candidate Scl target transcription factor genes, including Runx1 and Runx3. (ox.ac.uk)
- Furthermore, binding of an Scl-Lmo2-Gata2 complex was demonstrated to occur on the regions flanking the conserved E-boxes of the Runx1 loci and was shown to transactivate the Runx1 element. (ox.ac.uk)
- In situ hybridization using Runx1 and Runx2 specific probes indicate that both factors are expressed in mesenchymal stem cell progenitors during early embryonic development. (umassmed.edu)
- Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. (anticorps-enligne.fr)
- Under well-oxygenated conditions this complex binds directly to the alpha subunit of the heterodimeric transcription element HIF (hypoxia-inducible element) and focuses on it for proteasomal degradation. (ees2010prague.org)
- The structures reveal that eIF2 undergoes large rearrangements to promote binding of eIF2α to the regulatory core of eIF2B comprised of the eIF2B alpha, beta and delta subunits. (rcsb.org)
- However, the precise mechanisms by which these factors interact to form transcriptional networks, as well as the identity of the genes downstream of these regulatory cascades, remain largely unknown. (ox.ac.uk)
- KAT8 regulatory NSL complex subunit. (gsea-msigdb.org)
- ATP synthase membrane subunit e [So. (gsea-msigdb.org)
- Lingual and buccal mucosae and lung epithelial tissue infected by PPRV show significant inducible nitric oxide synthase (iNOS), interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) expression, which may play important roles in the initiation and regulation of the cytokine responses [ 18 ]. (biomedcentral.com)
- Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma). (embl-heidelberg.de)
- Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs. (embl-heidelberg.de)
- Eukaryotic Translation Initiation is governed by large initiation factor complexes, whose subunits are regulated in a largely discordant fashion. (escholarship.org)
- The Alliance for Cellular Signaling (AfCS) murine B cell single ligand screen with 33 ligands utilizing Agilent microarrays was analyzed for its effects on initiation factor gene expression. (escholarship.org)
- Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (cansar.ai)
- DAG1 senses a pathway enzyme age that acts an colorectal entry in the phagocytosis of the special Maturation in subunits, membrane, and other systems by binding the paralogous detail to immune anomalies. (familie-vos.de)
- Tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) is an interesting costimulatory molecule associated with T lymphocyte activation, and it mainly exerts its biological effects by binding to its receptors herpesvirus invasion mediator (HVEM) and lymphotoxin-ß receptor. (bvsalud.org)
- Finally, at the very C-termini of GCD6, eIF-2B epsilon, and two other eukaryotic translation initiation factors, eIF-4 gamma and eIF-5, there is a previously undetected, conserved domain. (embl-heidelberg.de)
- Family members contain a highly conserved DNA -binding domain known as the runt domain. (bvsalud.org)
- putative DNA-binding transcriptional regulator [Ensembl]. (ntu.edu.sg)
- A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. (bvsalud.org)
- In silico analysis of seabream BMP2 promoter revealed several binding sites for bone and cartilage related transcription factors (TFs) and their functionality was evaluated using promoter-luciferase constructions and TF-expressing vectors. (ualg.pt)
- The Runx family of transcription factors play a fundamental role in organ development and cell differentiation. (umassmed.edu)
- To identify upstream regulators of the Runx2-P1 promoter, we screened 100 transcription factors using Runx2-P1-luciferase reporter constructs in NIH3T3 fibroblasts and HeLa cells. (nbrp.jp)
- We present a model for controlled nucleotide exchange and initiator tRNA binding to the eIF2/eIF2B complex. (rcsb.org)
- A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. (cansar.ai)
- Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis. (colorado.edu)
- To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
- These toxins bind to specific receptors of the intestinal epithelial cells and cause secretion of water and electrolytes into the intestinal lumen. (cdc.gov)
- This narrative review provides an update on the impact of vitamin D on hormone receptors, notably estrogen receptor subunits, and gives insights on possible therapeutic interventions to overcome breast cancer. (qualitycounts.com)
- Pueden actuar tanto como activadores como de represores de la expresión de GENES involucrados en la DIFERENCIACIÓN CELULAR y en la progresión DEL CICLO CELULAR. (bvsalud.org)
- 18 hub genes were selected in PPI network, among which there were 6 core genes evaluated by DAVID. (researchsquare.com)
- The RNA tolerating factors need catabolized to avoid balconies- in genes segregated in Lebanese lymphocytes like tumor chromatin, glutamine cell The PI3K genes of complex and acetate salts mediates outlined also. (familie-vos.de)
- Although to a lesser extent, myocyte enhancer factor 2C (MEF2C) had also a negative effect on the regulation of BMP2 gene transcription, when associated with SRY (sex determining region Y)-box 9 (SOX9b). (ualg.pt)
- A comprehensive set of core promoter motifs are detected at boundaries, including the newly discovered M1BP motif, and motifs which have been associated to housekeeping gene expression. (sdbonline.org)
- eIF2, which is inactivated upon phosphorylation of subunit 1 by alpha kinases 1-4, was seen to have discordant regulation of subunits and differing levels of kinase gene expression for different ligands, indicating a high degree of variability in global translation. (escholarship.org)
- Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids. (gu.se)
- In conclusion, this study demonstrates the early cellular gene expression in the caprine endometrial epithelial cells after the binding and entry of PPRV. (biomedcentral.com)
- Sister-chromatid cohesion is mediated by cohesin, a ring-shape complex made of four core subunits called Scc1, Scc3, Smc1, and Smc3 in Saccharomyces cerevisiae(Rad21, Psc3, Psm1, and Psm3 in Schizosaccharomyces pombe). (ens-lyon.fr)
- Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)
- Runt-related transcription factor 3 (RUNX3) was shown to negatively regulate BMP2 transcription and combination with the core binding factor β (CBFβ) further reduced transcriptional activity of the promoter. (ualg.pt)
- Motif calling was performed at boundaries, validating the presence of known insulators, along with M1BP motif, which recently has also been shown to be associated to boundaries and core promoter motif 6 and motif 8, which have not been associated to boundaries before. (sdbonline.org)
- Which of the following region in sigma factor binds to the core promoter -10 box? (paperforpay.com)
- An electrophoretic mobility shift assay and chromatin immunoprecipitation assay confirmed the binding of HIF2A to the Runx2-P1 promoter in vitro and in vivo, respectively. (nbrp.jp)
- Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (cansar.ai)
- eIF3, a large complex with at least 10 subunits, is seen to have discordant regulation of its subunits as well, even for a conserved 'core' complex, attesting to their dual functions in cellular machinery. (escholarship.org)
- eIF4, a complex consisting of 3 subunits with multiple subunit isoforms, was seen to express only eIF4G isoform 3 in murine B cells. (escholarship.org)
- Coimmunoprecipitation experiments indicate that myogenin contacts the pol II complex and that the RPB3 subunit is responsible for this interaction. (elsevier.com)
- COPI coat complex subunit zeta 1 [S. (gsea-msigdb.org)
- Specifically, pVHL is the substrate acknowledgement subunit of a ubiquitin ligase complex that also contains elongin B, elongin C, Cul2, and Rbx1 . (ees2010prague.org)
- Ssl3 is in complex with Mis4 and, as a bona fide loading factor, Ssl3 is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion is established. (ens-lyon.fr)
- Heritability estimates of complex traits such as loneliness may change across the lifespan, however, as the frequency, duration, and range of exposure to environmental influences accrues, or as the expression of genetic factors changes. (cdc.gov)
- To provide insight into the mechanism of translational control we have determined the structures of eIF2 both in phosphorylated and unphosphorylated forms bound with its nucleotide exchange factor eIF2B by electron cryomicroscopy. (rcsb.org)
- Only minor differences are observed between eIF2 and eIF2αP binding to eIF2B, suggesting that the higher affinity of eIF2αP for eIF2B drives translational control. (rcsb.org)
- Together with the third unique motif adjacent to the the P-loop, these motifs comprise the signature of a new superfamily of nucleotide-binding domains. (embl-heidelberg.de)
- cytochrome c oxidase subunit 6B1 [S. (gsea-msigdb.org)
- cytochrome c oxidase subunit 6C [So. (gsea-msigdb.org)
- Fail-safe control of translation initiation by dissociation of eIF2 alpha phosphorylated ternary complexes. (rcsb.org)
- Three conserved motifs, one of which appears to be a variant of the phosphate-binding site (P-loop) and another that may be considered a specific version of the Mg(2+)-binding site of NTP-utilizing enzymes, were identified in the nucleotidyltransferase-related domain. (embl-heidelberg.de)
- Phage integrase family, Arm DNA-binding domain [Interproscan]. (ntu.edu.sg)
- HTH-like domain, Integrase core domain [Interproscan]. (ntu.edu.sg)
- pVHL contains two hot-spots for missense mutations, called the alpha domain name and the beta domain name. (ees2010prague.org)
- Characterization of the Nurr1 ligand-binding domain co-activator interaction surface. (ens-lyon.fr)
- The recently solved crystal structure of the orphan nuclear receptor (NR) Nurr1 ligand-binding domain (LBD) showed that Nurr1 lacks a cavity for ligand binding and a canonical NR co-activator-binding site. (ens-lyon.fr)
- S1 RNA binding domain, Ribonuclease E/G family, Polyribonucleotide phosphorylase C terminal [Interproscan]. (ntu.edu.sg)
- The N-terminal CH domain has the intrinsic ability to bind actin, albeit with lower affinity than the complete ABD, whereas the C-terminal CH bind actin extremely weakly or not at all. (embl.de)
- Binds these RNAs through its zinc fingers. (cansar.ai)
- connecting and Following RNAs can mediate grams from binding to cellular replication. (familie-vos.de)
- A proposed mechanism, based on the extrusion of DNA by cohesin, suggests that the DNA-binding motif of CTCF and its orientation determine the start and end of the loop. (sdbonline.org)
- Key residues involved in CDR I peptide/GM-CSFR binding were identified by truncation and alteration of individual residues, while the structural elements required to antagonize the biological action of GM-CSF were separately tested in binding and inhibitory activity assays of multiple cyclic analogues. (elsevier.com)
- Familia de factores de transcripción que se unen al cofactor SUBUNIDAD BETA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL para formar el factor de unión al sitio principal. (bvsalud.org)
- core-binding factor subunit beta [S. (gsea-msigdb.org)
- Directed mutagenesis identifies amino acid residues involved in elongation factor Tu binding to yeast Phe-tRNAPhe. (colorado.edu)
- Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. (cansar.ai)
- Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukayrotic initiation factors (eIFs) are included. (embl-heidelberg.de)
- These results indicate for the first time that the RPB3 pol II subunit is involved in the regulation of tissue-specific transcription. (elsevier.com)
- A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. (ens-lyon.fr)
- Vitamin D: an essential adjuvant therapeutic agent in breast cancer - J Int Med Res 2022 Jul - 'Low serum levels of vitamin D have been reported as a risk factor for breast cancer. (qualitycounts.com)
- It is of interest that an interaction between RPB3 and the myogenic transcription factor myogenin was identified. (elsevier.com)
- Although RPB3 contacts the basic helix-loop-helix (HLH) region of myogenin, it does not bind other HLH myogenic factors such as MyoD, Myf5, and MRF4. (elsevier.com)