AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
Core Binding Factor alpha SubunitsCore Binding FactorsCore Binding Factor Alpha 1 SubunitCore Binding Factor beta SubunitCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitTranscription Factor AP-2Smooth Muscle MyosinsTranscription FactorsChromosomes, Human, Pair 16DNA-Binding ProteinsChromosome InversionMolecular Sequence DataLeukemia, Myeloid, AcuteBase SequenceOncogene Proteins, FusionProtein SubunitsProtein BindingBinding SitesChromosomes, Human, Pair 21Neoplasm ProteinsDictionaries, MedicalPubMedPeriodicals as TopicBooksPublishingGene Regulatory NetworksCell DifferentiationCell LineageCleidocranial DysplasiaCranial SuturesClavicleTooth, SupernumeraryTooth, UneruptedJaw AbnormalitiesAntibodiesAntibodies, MonoclonalAntibody SpecificityAntibodies, ViralAntibodies, BacterialAntibodies, NeutralizingBiotin
Core Binding Factor alpha Subunits
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factors
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 1 Subunit
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
Core Binding Factor beta Subunit
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 2 Subunit
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
Core Binding Factor Alpha 3 Subunit
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.
Transcription Factor AP-2
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Smooth Muscle Myosins
Myosin type II isoforms found in smooth muscle.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Chromosomes, Human, Pair 16
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Chromosome Inversion
An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Oncogene Proteins, Fusion
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
Protein Subunits
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Chromosomes, Human, Pair 21
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Dictionaries, Medical
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Periodicals as Topic
A publication issued at stated, more or less regular, intervals.
Books
Publishing
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Gene Regulatory Networks
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Cell Differentiation
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Cell Lineage
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Cleidocranial Dysplasia
Autosomal dominant syndrome in which there is delayed closing of the CRANIAL FONTANELLES; complete or partial absence of the collarbones (CLAVICLES); wide PUBIC SYMPHYSIS; short middle phalanges of the fifth fingers; and dental and vertebral anomalies.
Cranial Sutures
A type of fibrous joint between bones of the head.
Clavicle
A bone on the ventral side of the shoulder girdle, which in humans is commonly called the collar bone.
Tooth, Supernumerary
An extra tooth, erupted or unerupted, resembling or unlike the other teeth in the group to which it belongs. Its presence may cause malposition of adjacent teeth or prevent their eruption.
Tooth, Unerupted
A normal developing tooth which has not yet perforated the oral mucosa or one that fails to erupt in the normal sequence or time interval expected for the type of tooth in a given gender, age, or population group.
Jaw Abnormalities
Congenital absence of or defects in structures of the jaw.
Antibodies
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Antibody Specificity
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies, Viral
Immunoglobulins produced in response to VIRAL ANTIGENS.
Antibodies, Bacterial
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Antibodies, Neutralizing
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Biotin
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. (1/119)

AML1 is one of the most frequently translocated genes in human leukemia. Here we demonstrate that acute myeloid leukemia-1 (AML-1) (Runx-1) represses transcription from a native promoter, p21(Waf1/Cip1). Unexpectedly, this repression did not require interactions with the Groucho co-repressor. To define the mechanism of repression, we asked whether other co-repressors could interact with AML-1. We demonstrate that AML-1 interacts with the mSin3 co-repressors. Moreover, endogenous AML-1 associated with endogenous mSin3A in mammalian cells. A deletion mutant of AML-1 that did not interact with mSin3A failed to repress transcription. The AML-1/mSin3 association suggests a mechanism of repression for the chromosomal translocation fusion proteins that disrupt AML-1.  (+info)

Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. (2/119)

Mice lacking the AML1/PEBP2alphaB/CBFa2 gene or PEBP2beta/CBFb gene exhibit a defect in definitive hematopoiesis and die in utero because of hemorrhage in the central nervous system. Hematopoiesis in the embryo is considered to be tightly associated with vascular development. Here we examined whether PEBP2/CBF plays any role in angiogenesis besides that in definitive hematopoiesis. We found that AML1/PEBP2alphaB/CBFa2, PEBP2alphaA/CBFa1, and PEBP2beta/CBFb were expressed in a murine endothelial cell line MSS31. The expression of these molecules as well as the DNA binding activity of PEBP2/CBF were augmented by angiogenic growth factors such as bFGF and VEGF. Moreover, the expression of PEBP2 alpha/CBFa protein in endothelial cells was confirmed at the site of angiogenesis in vivo. To further clarify the role of PEBP2/CBF in angiogenesis, we established permanent transfectants of PEBP2 beta-MYH11 gene, one that interacts with the runt domain of the alpha subunit and deregulates PEBP2/CBF in a dominant interfering manner. Proliferation, migration, and tube formation of the PEBP2 beta-MYH11 transfectants were significantly reduced in comparison with those activities of the mock transfectants. These results suggest that transcription factor PEBP2/CBF plays an important role in angiogenesis.  (+info)

Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA. (3/119)

Core binding factors (CBFs) play key roles in several developmental pathways and in human disease. CBFs consist of a DNA binding CBFalpha subunit and a non-DNA binding CBFbeta subunit that increases the affinity of CBFalpha for DNA. We performed sedimentation equilibrium analyses to unequivocally establish the stoichiometry of the CBFalpha:beta:DNA complex. Dissociation constants for all four equilibria involving the CBFalpha Runt domain, CBFbeta, and DNA were defined. Conformational changes associated with interactions between CBFalpha, CBFbeta, and DNA were monitored by nuclear magnetic resonance and circular dichroism spectroscopy. The data suggest that CBFbeta 'locks in' a high affinity DNA binding conformation of the CBFalpha Runt domain.  (+info)

Runt domain factor (Runx)-dependent effects on CCAAT/ enhancer-binding protein delta expression and activity in osteoblasts. (4/119)

Transcription factor CCAAT/enhancer-binding protein delta (C/EBPdelta) is normally associated with acute-phase gene expression. However, it is expressed constitutively in primary osteoblast cultures where it increases insulin-like growth factor I synthesis in a cAMP-dependent way. Here we show that the 3' proximal region of the C/EBPdelta gene promoter contains a binding sequence for Runt domain factor Runx2, which is essential for osteogenesis. This region of the C/EBPdelta promoter directed high reporter gene expression in osteoblasts, and specifically bound Runx2 in osteoblast-derived nuclear extract. C/EBPdelta gene promoter activity was reduced by mutating the Runx binding sequence or by co-transfecting with Runx2 antisense expression plasmid, and was enhanced by overexpression of Runx-2. Exposure to prostaglandin E(2) increased Runx-dependent gene transactivation independently of Runx2 binding to DNA. Runx2 bound directly to the carboxyl-terminal region of C/EBPdelta itself, and its ability to drive C/EBPdelta expression was suppressed when C/EBPdelta or its carboxyl-terminal fragment was increased by overexpression. Consistent effects also occurred on C/EBPdelta-dependent increases in gene expression driven by synthetic or insulin-like growth factor I gene promoter fragments. These interactions between Runx2 and C/EBPdelta, and their activation by prostaglandin E(2), provide new evidence for their importance during skeletal remodeling, inflammatory bone disease, or fracture repair.  (+info)

Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha. (5/119)

Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play critical roles in several developmental pathways, including hematopoiesis and bone development. Mutations in CBF genes are found in leukemias and bone disorders. CBFs consist of a DNA-binding CBFalpha subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBFbeta subunit. CBFalpha binds DNA in a sequence-specific manner, whereas CBFbeta enhances DNA binding by CBFalpha. Recent structural analyses of the DNA-binding Runt domain of CBFalpha and the CBFbeta subunit identified the heterodimerization surfaces on each subunit. Here we identify amino acids in CBFbeta that mediate binding to CBFalpha. We determine the energy contributed by each of these amino acids to heterodimerization and the importance of these residues for in vivo function. These data refine the structural analyses and further support the hypothesis that CBFbeta enhances DNA binding by inducing a conformational change in the Runt domain.  (+info)

Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. (6/119)

Hairy/Enhancer of split 1 (Hes1) is a mammalian transcriptional repressor that plays crucial roles in the regulation of several developmental processes, including neuronal differentiation. The aim of this study was to elucidate the molecular mechanisms that regulate the transcription repression activity of Hes1. It is shown here that Hes1 associates with the nuclear matrix, the ribonucleoprotein network of the nucleus that plays important roles in transcriptional regulation. Nuclear matrix binding is mediated by the same Hes1 C-terminal domain that is also required for transcriptional repression. This domain contains the WRPW motif that acts as a binding site for the transcriptional corepressor Groucho, which also localizes to the nuclear matrix. Both the nuclear matrix association and transcription repression activity of Hes1 are inhibited by deletion of the WRPW motif, indicating that Groucho acts as a transcriptional corepressor for Hes1. This corepressor role is not modulated by the Groucho-related gene product Grg5. In contrast, the Runt-related protein RUNX2, which localizes to the nuclear matrix and interacts with Groucho and Hes1, can inhibit both the Groucho.Hes1 interaction and the transcription repression ability of Hes1. Together, these observations suggest that transcriptional repression by Hes1 requires interactions with Groucho at the nuclear matrix and that RUNX proteins act as negative regulators of the repressive activity of Groucho.Hes1 complexes.  (+info)

Cloning and embryonic expression patterns of the zebrafish Runt domain genes, runxa and runxb. (7/119)

We isolated zebrafish homologues of the Runt-related transcription factor gene family (Runx family), runxa and runxb, and analyzed their developmental expression patterns. The deduced amino acid sequence of Runxa was highly homologous to that of AML1 (also called CBFA2, PEBP2alphaB or Runx1), a critical regulator of mammalian hematopoiesis expressed in cells of the hematopoietic lineage as well as other tissues. During zebrafish development, the runxa gene was not expressed in hematopoietic tissues but in the olfactory placodes and cells attached to the otic vesicles. We identified three kinds of runxb transcripts, which encoded two types of proteins with different N-terminal regions. The Runxb proteins were highly similar to AML2 (CBFA3, PEBP2alphaC or Runx3). The expression sites of the shared region of runxb mRNAs during development were the trigeminal ganglions, dorsal neurons of the neural tube and the lateral line primordia. These findings show that expression patterns of the zebrafish Runx genes are distinct from that of the mammalian genes.  (+info)

Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. (8/119)

Mammalian CBFB encodes a transcription factor (CBF beta) that in combination with CBF alpha 2 binds to specific DNA sequences and regulates expression of a number of hematopoietic genes. CBFB is associated with human leukemias through a chromosome 16 inversion and is essential for definitive hematopoiesis during mouse embryo development. We have isolated a zebrafish cbfb complementary DNA (cDNA) clone from a zebrafish kidney cDNA library. This cbfb is highly homologous to human and mouse CBFB/Cbfb genes at both the DNA and protein level. In biochemical analyses, cbfbeta binds to human CBF alpha 2 and enhances its DNA binding. During zebrafish development, cbfb is expressed in the lateral plate mesoderm at tail bud stage and in the intermediate cell mass (ICM, the location of embryonic hematopoiesis) between the 21- to 26-somite stages. The cbfb is also expressed in Rohon-Beard cells, cranial nerve ganglia, hindbrain, retina, branchial arches, jaw, and fin buds. Expression of cbfb is decreased or absent in the ICM and Rohon-Beard cells in some hematopoietic mutants and is unaffected in others. We have also analyzed the expression of scl and gata-1 in the same hematopoietic mutants to ascertain the relative order of these transcription factors to cbfb in zebrafish hematopoiesis. Our results indicate that cbfb is expressed in early hematopoietic progenitors and that its expression pattern in the hematopoietic mutants is similar to that of scl. (Blood. 2000;96:4178-4184)  (+info)

Runx-dependent expression of PKC is critical for cell survival in the by Carrie Dickey-Sims, Anthony J. Robertson et al.Runx-dependent expression of PKC is critical for cell survival in the by Carrie Dickey-Sims, Anthony J. Robertson et al.
BACKGROUND: Runx transcription factors play critical roles in the developmental control of cell fate and contribute variously as oncoproteins and tumor suppressors to leukemia and other cancers. To discover fundamental Runx functions in the cell biology of animal development, we have employed morpholino antisense-mediated knockdown of the sea urchin Runx protein SpRunt-1. Previously we showed that embryos depleted of SpRunt-1 arrest development at early gastrula stage and underexpress the conventional protein kinase C SpPKC1. RESULTS: We report here that SpRunt-1 deficiency leads to ectopic cell proliferation and extensive apoptosis. Suppression of the apoptosis by pharmacological inhibition of caspase-3 prevents the ectopic proliferation and rescues gastrulation, indicating that many of the overt defects obtained by knockdown of SpRunt-1 are secondary to the apoptosis. Inhibition or knockdown of SpPKC1 also causes apoptosis, while cell survival is rescued in SpRunt-1 morphant embryos coinjected with
https://uknowledge.uky.edu/physiology_facpub/33/
RUNX Proteins in Development and Cancer Buch versandkostenfrei bei Weltbild.de bestellenRUNX Proteins in Development and Cancer Buch versandkostenfrei bei Weltbild.de bestellen
Bücher bei Weltbild: Jetzt RUNX Proteins in Development and Cancer versandkostenfrei online kaufen bei Weltbild, Ihrem Bücher-Spezialisten!
https://www.weltbild.de/artikel/buch/runx-proteins-in-development-and-cancer_22208688-1
Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors | DevelopmentResolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors | Development
There was an error published in Development 132, 4635-4644.. In Fig. 2, the incorrect image was shown in panel K. Owing to an error during figure assembly, Fig. 2K is a duplication of the wild-type embryo image shown in Fig. 5A. The corrected Fig. 2 appears below.. This error does not affect the conclusions of the paper. The authors apologise to readers for this mistake. ...
https://dev.biologists.org/content/143/1/180
Transcriptional regulation in helper versus cytotoxic-lineage decision. - Semantic ScholarTranscriptional regulation in helper versus cytotoxic-lineage decision. - Semantic Scholar
The mechanism underlying the lineage decision made by CD4(+)CD8(+) double-positive (DP) thymocytes that give rise to two T lymphocyte subset with distinct functionalities, that is, helper and cytotoxic T cells, remains a major issue in immunology. The lineage decision process involves several phases and terminates when cells loose their developmental plasticity to become the alternate lineage. A detailed picture of the transcription factor network governing helper versus cytotoxic-lineage decision has recently emerged. Studies published only past year provided new insights into how the expression of ThPOK, a central transcription factor for helper T cell development, is regulated. It has now become evident that an antagonistic interplay between ThPOK and Runx transcription factor complexes plays an essential role in thwarting an alternate fate during the commitment process.
https://www.semanticscholar.org/paper/Transcriptional-regulation-in-helper-versus-cytoto-Taniuchi/64359d00ab8cee23a95898aa25d6ce2bca7ccb2c
University of Birmingham research gatewayUniversity of Birmingham research gateway
RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies. ...
https://research.birmingham.ac.uk/portal/en/publications/runx1-structure-and-function-in-blood-cell-development
JCI - Genetic regulation of the RUNX transcription factor family has antitumor effectsJCI - Genetic regulation of the RUNX transcription factor family has antitumor effects
Cell proliferation. To assess cell proliferation, 1 × 105 cells of the indicated AML-derived cells were seeded in 6-well plates. For the tetracycline-inducible gene or shRNA expression, doxycycline was added to the culture at a final concentration of 3 μM. Trypan blue dye exclusion assays were performed every other day.. RT-qPCR. Total RNA was isolated with an RNeasy Mini Kit (Qiagen) and reverse transcribed with a ReverTra Ace kit (TOYOBO) to generate cDNA. RT-qPCR was carried out with a 7500 Real-Time PCR System (Applied Biosystems) according to the manufacturers instructions. The results were normalized to GAPDH levels. Relative expression levels were calculated using the 2-ΔΔCt method. Primers used for RT-qPCR are listed in Supplemental Table 3.. ChIP-qPCR. ChIP was performed using a SimpleChIP Plus Enzymatic Chromatin IP Kit (Cell Signaling Technology) according to the manufacturers instructions. In brief, cells were cross-linked in 1% formaldehyde in PBS for 10 minutes at room ...
https://gimee-gz.com.www.mobile.jci.org/articles/view/91788
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/18037406?dopt=Abstract
User contributions for Solb - corebootUser contributions for Solb - coreboot
21:06, 7 May 2015 (diff , hist) . . (+3,779)‎ . . CBFS ‎ (Discussion of coreboot/libpayload future Redesign work, as well as the associated Remaining Design Work) ...
https://www.coreboot.org/index.php?title=Special:Contributions/Solb&printable=yes
core binding factor alpha Summary Report | CureHuntercore binding factor alpha Summary Report | CureHunter
core binding factor alpha: core binding factor plays a key role in several development pathways and in human disease; has been sequenced
http://www.curehunter.com/public/keywordSummaryC406688-core-binding-factor-alpha.do
JCI - Genetic regulation of the RUNX transcription factor family has antitumor effectsJCI - Genetic regulation of the RUNX transcription factor family has antitumor effects
Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of evidence suggests that it has pro-oncogenic properties in acute myeloid leukemia (AML). Here we have demonstrated that the antileukemic effect mediated by RUNX1 depletion is highly dependent on a functional p53-mediated cell death pathway. Increased expression of other RUNX family members, including RUNX2 and RUNX3, compensated for the antitumor effect elicited by RUNX1 silencing, and simultaneous attenuation of all RUNX family members as a cluster led to a much stronger antitumor effect relative to suppression of individual RUNX members. Switching off the RUNX cluster using alkylating agent-conjugated pyrrole-imidazole (PI) polyamides, which were designed to specifically bind to consensus RUNX-binding sequences, was highly effective against AML cells and against several poor-prognosis solid tumors in a xenograft mouse model of AML without ...
https://www.jci.org/articles/view/91788/figure/1
Modulation of Runx proteins by steroid hormone receptors :: University of Southern California Dissertations and ThesesModulation of Runx proteins by steroid hormone receptors :: University of Southern California Dissertations and Theses
Estrogen receptor α (ER α) and androgen receptor (AR) are master transcription factors in the breast and prostate, respectively. They are commonly known in development of sexual characteristics. However, both ERα and AR have been known to be involved in breast cancer (BCa) and prostate cancer (PCa) progression, respectively. The Runx family of transcription factors plays a role in hematopoiesis (Runx1), skeletogenesis (Runx2) and neurogenesis (Runx3). In addition, Runx proteins inhibit cell cycle progression, and have been assigned tumor suppressor roles in various contexts. Because both BCa and PCa cells metastasize to bone at high frequency, investigators have interrogated the possibility that they share characteristics with osteoblasts. Indeed, BCa and PCa cells were found to have osteomimetic properties, including expression of Runx2 and Runx2-target genes otherwise expressed by osteoblasts. Provoked by the reported physical interaction between AR and Runx2, we initiated a study to test ...
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/153892/rec/3
Runx Expression in Normal and Osteoarthritic Cartilage: Possible Funct by Kimberly T. LeBlancRunx Expression in Normal and Osteoarthritic Cartilage: Possible Funct by Kimberly T. LeBlanc
The Runx family of transcription factors supports cell fate determination, cell cycle regulation, global protein synthesis control, and genetic as well as epigenetic regulation of target genes. Runx1, which is essential for hematopoiesis; Runx2, which is required for osteoblast differentiation; and Runx3, which is involved in neurologic and gut development; are expressed in the growth plate during chondrocyte maturation, and in the chondrocytes of permanent cartilage structures. While Runx2 is known to control genes that contribute to chondrocyte hypertrophy, the functions of Runx1 and Runx3 during chondrogenesis and in cartilage tissue have been less well studied. The goals of this project were to characterize expression of Runx proteins in articular cartilage and differentiating chondrocytes and to determine the contribution of Runx1 to osteoarthritis (OA). Here, the expression pattern of Runx1 and Runx2 was characterized in normal bovine articular cartilage. Runx2 is expressed at higher levels in
http://escholarship.umassmed.edu/gsbs_diss/655/
Salivary Gland Development - EmbryologySalivary Gland Development - Embryology
Runx1 mediates the development of the granular convoluted tubules in the submandibular glands[1] The mouse granular convoluted tubules (GCTs), which are only located in the submandibular gland (SMG) are known to develop and maintain their structure in an androgen-dependent manner. We previously demonstrated that the GCTs are involuted by the epithelial deletion of core binding factor β (CBFβ), a transcription factor that physically interacts with any of the Runt-related transcription factor (RUNX) proteins (RUNX1, 2 and 3). This result clearly demonstrates that the Runx /Cbfb signaling pathway is indispensable in the development of the GCTs. However, it is not clear which of the RUNX proteins plays useful role in the development of the GCTs by activating the Runx /Cbfb signaling pathway. Past studies have revealed that the Runx /Cbfb signaling pathway plays important roles in various aspects of development and homeostatic events. Moreover, the Runx genes have different temporospatial ...
https://embryology.med.unsw.edu.au/embryology/index.php/Salivary_Gland_Development
Truncated forms of RUNX3 unlike full length protein alter cell proliferation in a TGF-β context dependent mannerTruncated forms of RUNX3 unlike full length protein alter cell proliferation in a TGF-β context dependent manner
The Runt related transcription factors (RUNX) are recognized as key players in suppressing or promoting tumor growth. RUNX3, a member of this family, is known as a tumor suppressor in many types of cancers, although such a paradigm was challenged by some researchers. The TGF-β pathway governs major upstream signals to activate RUNX3. RUNX3 protein consists of several regions and domains. The Runt domain is a conserved DNA binding domain and is considered as the main part of RUNX proteins since. Herein, we compared the effects of Runt domains and full-Runx3 in cell viability by designing two constructs of Runx3, including N-terminal region and Runt domain. We investigated the effect of full-Runx3, N-t, and RD on growth inhibition in AGS, MCF-7, A549, and HEK293 cell lines which are different in TGF-β sensitivity, in the absence and presence of TGF-β. The full length RUNX3 did not notably inhibit growth of these cell lines while, the N-t and RD truncates showed different trends in these cell lines.
http://ijpr.sbmu.ac.ir/article_2105.html
CBFB Gene - GeneCards | PEBB Protein | PEBB AntibodyCBFB Gene - GeneCards | PEBB Protein | PEBB Antibody
Complete information for CBFB gene (Protein Coding), Core-Binding Factor Beta Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CBFB
HAENLIN/WALTZER - STEM CELLS IN VIVO (a French network)HAENLIN/WALTZER - STEM CELLS IN VIVO (a French network)
Our team is interested in the mechanisms regulating blood cell fate during normal development or in pathological conditions such as leukemia or infection. In particular, we use Drosophila as a model system to investigate how blood cell progenitors are specified and how their maintenance is controlled. Notably, we aim at characterizing the different blood cell populations present in Drosophila at different stages of development and at defining the molecular signature and long term potential of Drosophila hematopoietic progenitors. An other aspect of our work focuses on the molecular mechanisms of action of conserved transcription factors implicated in hematopoiesis and leukemia, such as members of the GATA and RUNX families, and we try to define how they control blood cell programming and/or reprogramming ...
http://www.stemcells-live.fr/haenlinwaltzer.html
Core-binding factor, runt domain, alpha subunit 3 | definition of core-binding factor, runt domain, alpha subunit 3 by Medical...Core-binding factor, runt domain, alpha subunit 3 | definition of core-binding factor, runt domain, alpha subunit 3 by Medical...
Looking for online definition of core-binding factor, runt domain, alpha subunit 3 in the Medical Dictionary? core-binding factor, runt domain, alpha subunit 3 explanation free. What is core-binding factor, runt domain, alpha subunit 3? Meaning of core-binding factor, runt domain, alpha subunit 3 medical term. What does core-binding factor, runt domain, alpha subunit 3 mean?
https://medical-dictionary.thefreedictionary.com/core-binding+factor%2C+runt+domain%2C+alpha+subunit+3
Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute...Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute...
Approximately 40% of patients affected by core binding factor (CBF) acute myeloid leukemia (AML) ultimately die from the disease. Few prognostic markers have been identified. In this study we reviewed 192 patients with core binding factor acute myeloid leukemia (AML), treated with curative intent (age, 15-79 years) in 11 Italian institutions. Overall, 10-year overall survival (OS), disease-free survival (DFS), and event-free survival were 63.9%, 54.8%, and 49.9%, respectively; patients with the t(8;21) and inv(16) chromosomal rearrangements exhibited significant differences at diagnosis. Despite similarly high complete remission (CR) rate, patients with inv(16) experienced superior DFS and a high chance of achieving a second CR, often leading to prolonged OS also after relapse. We found that a complex karyotype (ie, ≥4 cytogenetic anomalies) affected survival; the KIT D816 mutation predicted worse prognosis only in patients with the t(8;21) rearrangement, whereas FLT3 mutations had no ...
http://amsacta.unibo.it/4423/
New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1 | Annals of the Rheumatic DiseasesNew targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1 | Annals of the Rheumatic Diseases
Yano et al show that TD-198946 strongly induced in vitro chondrogenic differentiation of progenitors, as evidenced by a marked increase in the chondrogenic markers type II collagen and aggrecan; it did this without promoting hypertrophy (type X collagen and metalloprotease 13).8. This interesting balance between chondrogenesis and hypertrophic differentiation may be because TD-198946 exerts its effect through regulating the expression of Runx1, a known inducer of chondrogenic differentiation and a suppressor of the subsequent hypertrophy.10 The mammalian Runx protein family comprises three transcription factors: Runx1, Runx2 and Runx3. All Runx proteins are expressed during chondrogenesis; however, experimental results show a distinct role for Runx proteins in chondrogenesis and subsequent chondrocyte maturation.12 ,13 Runx1 is highly expressed during chondrogenesis in comparison with Runx2. Overall, the expression of Runx1 remained significantly higher than Runx2 expression during early limb ...
https://ard.bmj.com/content/72/5/631
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceRUNX proteins in transcription factor networks that regulate T-cell lineage choice
Recent research has uncovered complex transcription factor networks that control the processes of T-cell development and differentiation. RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. In this Review, we examine the mechanisms …
https://pubmed.ncbi.nlm.nih.gov/19165227/?dopt=Abstract
TumorPortalTumorPortal
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two ...
http://tumorportal.org/view?geneSymbol=CBFB
A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells [PeerJ]A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells [PeerJ]
Background. Members of the Runx gene family encode transcription factors that bind to DNA in a sequence-specific manner. Among the three Runx proteins, Runx2 comprises 607 amino acid (aa) residues, is expressed in bone, and plays crucial roles in osteoblast differentiation and bone development. We examined whether the Runx2 gene is also expressed in testes. Methods. Murine testes from 1-, 2-, 3-, 4-, and 10-week-old male mice of the C57BL/6J strain and W∕Wv strain were used throughout the study. Northern Blot Analyses were performed using extracts form the murine testes. Sequencing of cDNA clones and 5′-rapid amplification of cDNA ends were performed to determine the full length of the transcripts, which revealed that the testicular Runx2 comprises 106 aa residues coding novel protein. Generating an antiserum using the amino-terminal 15 aa of Runx2 (Met1 to Gly15) as an antigen, immunoblot analyses were performed to detect the predicted polypeptide of 106 aa residues with the initiating Met1. With
https://peerj.com/articles/1862/
Biochemistry of Leukemia Virus Core Binding Factor - Nancy SpeckBiochemistry of Leukemia Virus Core Binding Factor - Nancy Speck
The Runx1-CBFbeta transcription factor is required for the emergence of all definitive hematopoietic cells. It is the earliest specific marker of sites from whi...
http://grantome.com/grant/NIH/R01-HL091724-19
The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML | JEMThe cell fate determinant Llgl1 influences HSC fitness and prognosis in AML | JEM
Decreased Llgl1 expression has been previously shown to be associated with increased metastatic potential, malignant phenotype, or inferior survival in a variety of solid tumors (Ohali et al., 2004; Schimanski et al., 2005; Kuphal et al., 2006). Given that Llgl1 restrains self-renewal in HSCs and that leukemia is characterized by aberrant activation of self-renewal, we assessed for a role in human AML. First, we asked whether the gene expression signature revealed by genetic inactivation of Llgl1 (Llgl1−/− signature) in HSCs was associated with any genetic subtypes of primary AML. Indeed, clustering based on the Llgl1−/− signature (Fig. 4 B) grouped AML cases into subgroups significantly associated with cytogenetic abnormalities (Fig. 4, B and C). Especially core-binding factor leukemias (t(8;21) and inv(16)) or t(15;17) clustered into specific subgroups. Moreover, the Llgl1−/− signature was most strongly correlated with group 7 based on hierarchical clustering. This group contained ...
http://jem.rupress.org/content/early/2012/12/24/jem.20120596
Rabbit Polyclonal Anti-RUNX3 Antibody, PA2112 | AMSBIORabbit Polyclonal Anti-RUNX3 Antibody, PA2112 | AMSBIO
Acute myeloid leukemia 2 protein antibody, Acute myeloid leukemia gene 2 antibody, AML 2 antibody, AML2 antibody, CBF alpha 3 antibody, CBF-alpha-3 antibody, CBFA 3 antibody, CBFA3 antibody, Core binding factor alpha 3 subunit antibody, core binding factor antibody, Core binding factor runt domain alpha subunit 3 antibody, Core binding factor subunit alpha 3 antibody, core-binding factor antibody, Core-binding factor subunit alpha-3 antibody, FLJ34510 antibody, MGC16070 antibody, Oncogene AML 2 antibody, Oncogene AML-2 antibody, PEA2 alpha C antibody, PEA2-alpha C antibody, PEBP2 alpha C antibody, PEBP2-alpha C antibody, Pebp2a3 antibody, PEBP2aC antibody, Polyomavirus enhancer binding protein 2 alpha C subunit antibody, Polyomavirus enhancer-binding protein 2 alpha C subunit antibody, runt domain alpha subunit 3 antibody, runt related transcription factor 3 antibody, Runt-related transcription factor 3 antibody, RUNX 3 antibody, Runx3 antibody, RUNX3_HUMAN antibody, SL3 3 enhancer factor 1 ...
https://www.amsbio.com/rabbit-polyclonal-anti-runx3-antibody-pa2112
Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048
Gentaur molecular products has all kinds of products like :search , Signosis 2011 \ TCF_LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048 for more molecular products just contact us
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Dasatinib in Combination With Chemotherapy for Relapsed or Refractory Core Binding Factor Acute Myeloid Leukemia: A Phase I...Dasatinib in Combination With Chemotherapy for Relapsed or Refractory Core Binding Factor Acute Myeloid Leukemia: A Phase I...
This study is examining the appropriate dose and side effects of dasatinib, when it is given with the standard of care chemotherapy for children and adolescents
http://adisinsight.springer.com/trials/700268025?error=cookies_not_supported&code=6603582c-7e06-46e5-bfb9-084b65d93573
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions<...New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions<...
TY - JOUR. T1 - New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions. AU - Schiano, Concetta. AU - Soricelli, Andrea. AU - de Nigris, Filomena. AU - Napoli, Claudio. PY - 2018/12/20. Y1 - 2018/12/20. N2 - INTRODUCTION: High-resolution imaging is the gold standard to measure the functional and biological features of bone lesions. Imaging markers have allowed the characterization both of tumour heterogeneity and metabolic data. Besides, ongoing studies are evaluating a combined use of imaging markers, such as SUVs, MATV, TLG, ADC from PET and MRI techniques respectively, and several biomarkers spanning from chemokine immune-modulators, such as PD-1, RANK/RANKL, CXCR4/CXCL12 to transcription factors, such as TP53, RB1, MDM2, RUNX family, EZH2, YY1, MAD2. Osteoimmunology may improve diagnosis and prognosis leading to precision medicine in bone lesion treatment. Areas covered: We investigated modalities (molecular and imaging approach) useful to identify bone ...
https://moh-it.pure.elsevier.com/en/publications/new-challenges-in-integrated-diagnosis-by-imaging-and-osteo-immun
Patent US7919153 - Laminated structure, process of producing a liquid crystal cell substrate ... - Google PatentsPatent US7919153 - Laminated structure, process of producing a liquid crystal cell substrate ... - Google Patents
A laminated structure comprising, at least one optically anisotropic layer formed of a liquid crystalline composition comprising a compound having two or more types of reactive groups, and at least one photosensitive polymer layer. The laminated structure is useful for forming an optically anisotropic layer inside of a liquid crystal cell. The laminated structure is also useful for forming a liquid crystal cell substrate with an optically anisotropic layer having an optically compensating ability, inside of a liquid crystal cell.
http://www.google.com.au/patents/US7919153
Dr Chen Hsung Edward Chew: Leukaemia FoundationDr Chen Hsung Edward Chew: Leukaemia Foundation
Among patients with good prognosis core binding factor AML, there is an overall survival rate of only 44%. To understand the genetic factors contributing to poor outcomes within this subgroup, Dr Chew is analysing bone marrow samples collected from 18 patients before and during treatment.. According to Dr Chew, multiple genetic abnormalities acquired during therapy are probably responsible for good prognosis core binding AML developing resistance to chemotherapy.. To help us predict who will respond poorly to therapy, were identifying the genetic mutations occurring in patients who relapse, he said. This information will allow us to tailor patient treatment accordingly. Currently a stem cell transplant is considered the definitive treatment and our findings will help clinicians decide if their patients AML will develop resistance and if a stem cell transplant is recommended.. Dr Chew is testing the usefulness of the genetic variations he identifies through an international ...
http://www.leukaemia.org.au/research/current-and-past-funding-recipients/2014-research-awards/dr-chen-hsung-edward-chew
Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website
RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding…
https://www.acris-antibodies.com/target/runx1-antibody.htm?p=2
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Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801<...Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801<...
TY - JOUR. T1 - Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia. T2 - CALGB 10801. AU - Marcucci, Guido. AU - Geyer, Susan. AU - Laumann, Kristina. AU - Zhao, Weiqiang. AU - Bucci, Donna. AU - Uy, Geoffrey L.. AU - Blum, William. AU - Eisfeld, Ann Kathrin. AU - Pardee, Timothy S.. AU - Wang, Eunice S.. AU - Stock, Wendy. AU - Kolitz, Jonathan E.. AU - Kohlschmidt, Jessica. AU - Mrózek, Krzysztof. AU - Bloomfield, Clara D.. AU - Stone, Richard M.. AU - Larson, Richard A.. N1 - Publisher Copyright: © 2020 by The American Society of Hematology. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/2/25. Y1 - 2020/2/25. N2 - Acutemyeloid leukemia (AML)witheither t(8;21)(q22;q22)or inv(16)(p13q22)/t(16;16)(p13;q22) is referred to as core binding factor (CBF) AML. Although categorized as favorable risk, long-term survival for these patients is only ∼50% to 60%. Mutated (mut) or overexpressed KIT, a gene encoding a ...
https://mayoclinic.pure.elsevier.com/en/publications/combination-of-dasatinib-with-chemotherapy-in-previously-untreate
Fluoride Action Network | Expression of core-binding factor a1 and osteocalcin in fluoride-treated fibroblasts and...Fluoride Action Network | Expression of core-binding factor a1 and osteocalcin in fluoride-treated fibroblasts and...
To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. Fibroblasts and osteoblasts were exposed to different concentrations of fluoride (0, 0.0001, 0.001, 0.1, 1.0, 10.0 and 20.0mg/L F-). By using RT-PCR and ELISA, the mRNA levels of Cbfa1 and OCN were measured at 48h, and the protein levels of Cbfa1 and OCN were measured at 2, 4, 24, 48 and 72h. The data demonstrated the following: (1) The Cbfa1 protein level in fluoride-treated fibroblasts clearly increased at 48h in the groups treated with 0.0001, 0.001, 0.1, 1.0 and 20.0mg/L F-. The Cbfa1 protein level of the group treated with 10mg/L F- at 72h was higher than that of the control group. The level of Cbfa1 mRNA in the fibroblasts ...
http://fluoridealert.org/studytracker/18674/
Dartmouth Digital Library ProgramDartmouth Digital Library Program
Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. Runx proteins are encoded by three genes: Runx1, Runx2 , and ...
http://libarchive.dartmouth.edu/cdm/search/searchterm/%CE%B1%252F%C3%9F/mode/all/order/subjec
RUNX3 expression in primary and metastatic pancreatic cancer | Journal of Clinical PathologyRUNX3 expression in primary and metastatic pancreatic cancer | Journal of Clinical Pathology
The pathogenesis of PDAC involves genetic alterations, such as K-ras protooncogene mutations, mutations of the p53, p16, and Smad4 tumour suppressor genes, and other less common mutations.2 In addition, there are numerous epigenetic alterations, including altered expression of several growth factors and their receptors.3 For example, PDACs overexpress all TGFβ isoforms and their receptors, and overexpression of these ligands and receptors is often associated with shortened postoperative survival of patients with pancreatic cancer.14,15. The TGFβ pathway is carefully regulated, with Smad proteins as the key component in the signal transduction pathway. In addition, other regulators, such as transcription factors, which facilitate Smad binding to target promoters, may provide routes for feedback and crosstalk.16 For example, members of the CBFA (core binding factor A) family of transcription factors act both as targets and partners of activated Smads. This family, also termed the Runx family, ...
http://jcp.bmj.com/content/57/3/294
JoVE Author Search: Qutub AAJoVE Author Search: Qutub AA
Cells, Lead, Acute Myeloid Leukemia, Bone, Bone Marrow, Core-binding Factor, Cytogenetic, Cytogenetic Abnormalities, Disease, Leukemia, Marrow, Myeloid Leukemia, Patient, Patients, Protein Array, Proteins, Regression, Regression Analysis, Ability, Algorithm
http://labindex.jove.com/author/Qutub-AA
Gästbok | Veteran-OLGästbok | Veteran-OL
Veteranorientering i nordvästra Skåne är en samling härliga människor som orienterar tillsammans varannan onsdag. Arrangemanget går runt på veteraner i de olika klubbarna i nordvästra Skåne och det är alltid start klockan 09.00. Varmt välkommen att bli en av oss ...
http://veteranol.hsok.se/gastbok/?from=4530&select=454
HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia<...HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia<...
TY - JOUR. T1 - HDAC1 is a required cofactor of CBFb-SMMHC and a potential therapeutic target in inversion 16 acute myeloid leukemia. AU - Richter, Lisa E.. AU - Wang, Yiqian. AU - Becker, Michelle E.. AU - Coburn, Rachel A.. AU - Williams, Jacob T.. AU - Amador, Catalina. AU - Hyde, R. Katherine. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv (16)], which generates a fusion between the genes for core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11), forming the oncogene CBFB-MYH11. The expressed protein, CBFb-SMMHC, forms a heterodimer with the key hematopoietic transcription factor RUNX1. Although CBFb-SMMHC was previously thought to dominantly repress RUNX1, recent work suggests that CBFb-SMMHC functions together with RUNX1 to activate transcription of specific target ...
https://nebraska.pure.elsevier.com/en/publications/hdac1-is-a-required-cofactor-of-cbfb-smmhc-and-a-potential-therap
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the regulatory mechanisms underlying RUNX1 expression in neuroblastoma (NB), a highly malignant tumor in childhood, remain largely unclear. In this study, we aimed to assess the role of RUNX1 in NB and to reveal the underlying mechanisms that may contribute to finding a potential therapeutics strategy against NB. Growth, invasion, metastasis and angiogenesis were assessed using Cell Counting Kit-8 (CCK-8) immunocytochemistry, and studies involving soft agar, cell invasion, tube formation and whole animals. The levels of expression were measured using real-time quantitative PCR for RNA, Western blot and immunostaining analyses for proteins. Luciferase reporter and chromatin immunoprecipitation assays indicated that RUNX1 directly binds within the BIRC5, CSF2RB and NFKBIA promoter regions to facilitate
https://jeccr.biomedcentral.com/articles/10.1186/s13046-020-01558-2
WikiGenes - RUNX1 - runt-related transcription factor 1WikiGenes - RUNX1 - runt-related transcription factor 1
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/gene/e/101058316.html
Theory of Nematic-smectic phase separation in thin twisted liquid crystal cells<...Theory of Nematic-smectic phase separation in thin twisted liquid crystal cells<...
TY - JOUR. T1 - Theory of Nematic-smectic phase separation in thin twisted liquid crystal cells. AU - Osipov, M.A.. AU - Sambles, J.R.. AU - Ruan, L.. PY - 2003/7/7. Y1 - 2003/7/7. N2 - Recently it has been shown experimentally by the authors that a highly twisted thin nematic cell at low temperatures can separate into a smectic A region in the middle of the cell surrounded by twisted nematic layers at the boundaries. In this case the twist is expelled into the nematic layers and the nematic-smectic A transition temperature is strongly depressed. We present a thermodynamic theory of such a phase transition in a twisted nematic cell, taking into account that the smectic A slab inside the nematic cell can be stable only if the decrease of free energy in the smectic region overcomes the increase in distortion energy of the twist deformation in the nematic layers plus the energy of the nematic-smectic A interface. In such a system the equilibrium thickness of the smectic A slab corresponds to the ...
https://pureportal.strath.ac.uk/en/publications/theory-of-nematic-smectic-phase-separation-in-thin-twisted-liquid
anti-RUNX1 antibody | GeneTexanti-RUNX1 antibody | GeneTex
RUNX1 antibody (runt-related transcription factor 1) for WB. Anti-RUNX1 pAb (GTX11903) is tested in Human, Mouse samples. 100% Ab-Assurance.
http://www.genetex.com/RUNX1-antibody-GTX11903.html
anti-RUNX1 antibody | GeneTexanti-RUNX1 antibody | GeneTex
RUNX1 antibody (runt-related transcription factor 1) for ICC/IF, WB. Anti-RUNX1 pAb (GTX129100) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
http://www.genetex.com/RUNX1-antibody-GTX129100.html
Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer<...Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer<...
TY - JOUR. T1 - Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer. AU - Horiguchi, Shigeru. AU - Shiraha, Hidenori. AU - Nagahara, Teruya. AU - Kataoka, Jyunnro. AU - Iwamuro, Masaya. AU - Matsubara, Minoru. AU - Nishina, Shinichi. AU - Kato, Hironari. AU - Takaki, Akinobu. AU - Nouso, Kazuhiro. AU - Tanaka, Takehiro. AU - Ichimura, Koichi. AU - Yagi, Takahito. AU - Yamamoto, Kazuhide. PY - 2013/8. Y1 - 2013/8. N2 - Background & Aim: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor gene that is expressed in gastric and other cancers including pancreatic cancer. However, the precise function of RUNX3 in pancreatic cancer has not been fully elucidated. In this study, we aimed to determine the effect of decreased RUNX3 expression in pancreatic cancer. Methods: This study included 36 patients with primary pancreatic cancer, who had undergone pancreaticoduodenectomy. All patients were treated with 1000mg/m2 gemcitabine after the surgery. ...
https://okayama.pure.elsevier.com/en/publications/loss-of-runt-related-transcription-factor-3-induces-gemcitabine-r
US6801183B2 - Temperature compensation for liquid crystal cell optical devices - Google PatentsUS6801183B2 - Temperature compensation for liquid crystal cell optical devices - Google Patents
A temperature compensation circuit arrangement for liquid crystal cells in optical devices is presented. In an optical device, a liquid crystal cell typically manipulates the optical signals according to an output optical property, such as attenuation, responsive to an AC voltage source electrical signal. A feedback circuit arrangement is connected to the liquid crystal cell and controls the current through the liquid crystal cell with respect to temperature by a predetermined control equations for the output optical property so that the device manipulates the optical signals independently of temperature. The current follows the control equations, which are empirically determined with respect to temperature for one equation.
https://patents.google.com/patent/US6801183B2/en
Dartmouth Digital Library ProgramDartmouth Digital Library Program
Core-binding factors (CBFs) are a small family of transcription factors that play important roles in several developmental processes and in human disease. CBFs consist of CBFα (Runx1, Runx2, or Runx3) and CBFβ. The CBFα subunit binds DNA in a ...
https://libarchive.dartmouth.edu/cdm/search/searchterm/screen
Bob Ohgami, MD, PhD | UCSF Helen Diller Family Comprehensive Cancer CenterBob Ohgami, MD, PhD | UCSF Helen Diller Family Comprehensive Cancer Center
Ustun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, Broesby-Olsen S, Ohgami R, Kim Y, Sperr W, Vestergaard H, Chen D, Kluin PM, Dolan M, Mrózek K, Czuchlewski D, Horny HP, George TI, Kristensen TK, Ku NK, Yi CA, Møller MB, Marcucci G, Baughn L, Schiefer AI, Hilberink JR, Pullarkat V, Shanley R, Kohlschmidt J, Coulombe J, Salhotra A, Soma L, Cho C, Linden MA, Akin C, Gotlib J, Hoermann G, Hornick J, Nakamura R, Deeg J, Bloomfield CD, Weisdorf D, Litzow MR, Valent P, Huls G, Perales MA, Borthakur G Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit). View on PubMed ...
https://cancer.ucsf.edu/people/ohgami.bob
Policie zadr ela mu e v kost mu z Falloutu. Spletla si ho s teroristou - iDNES.czPolicie zadr ela mu e v kost mu z Falloutu. Spletla si ho s teroristou - iDNES.cz
Ve vojensk m oble en , s kovovou helmou na hlav a atrapami v bu nin se fanou ek Falloutu proch zel centrem m sta, jako by se nechumelilo.
https://bonusweb.idnes.cz/policie-zadrzela-muze-v-kostymu-z-falloutu-spletla-si-ho-s-teroristou-1z4-/Magazin.aspx?c=A170417_192546_bw-magazin_srp
Stem Cell Modeling of Core Binding Factor Acute Myeloid LeukemiaStem Cell Modeling of Core Binding Factor Acute Myeloid Leukemia
Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.
https://www.hindawi.com/journals/sci/2016/7625827/abs/
Clinical Trial: NCT02680951 - My Cancer GenomeClinical Trial: NCT02680951 - My Cancer Genome
This Phase I study is for children and adolescents who have acute myelogenous leukemia (AML) that has come back (relapsed) or has become resistant (refractory) to standard therapies. Researchers want to know if a drug called dasatinib is safe when used together with standard chemotherapy in treating patients who have relapsed or have resistant AML. Their leukemia has a particular genetic mutation, called core-binding factor. This type of leukemia has an increase of a cancer promoting protein called c-KIT. Dasatinib can target this protein in laboratory experiments. Laboratory and other studies suggest that dasatinib may prevent acute myeloid leukemia cells from growing and may lead to the destruction of leukemia cells. The main goal of this study is to find a safe dose of dasatinib and to find out the side effects of dasatinib when it is given in combination with standard chemotherapy to children and adolescents. Similar studies are currently being done in adult patients. Dasatinib has been ...
https://www.mycancergenome.org/content/clinical_trials/NCT02680951/
JoVE Author Search: Balla JJoVE Author Search: Balla J
Disease, Muscle, Muscle Cells, Smooth Muscle, Smooth Muscle Cells, Cells, Heme, Hydrogen, Alkaline Phosphatase, Kidney, Kidney Disease, Osteocalcin, Upregulation, Vascular Calcification, Calcium, Heme Oxygenase, Vascular Smooth Muscle, Atherosclerosis, Bone, Core Binding Factor
http://labindex.jove.com/author/Balla-J
Publications - Mayo ClinicPublications - Mayo Clinic
van der Deen M, Taipaleenmaki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19; 288(29):21307-19. Epub 2013 May 29 ...
http://www.mayo.edu/research/searchpublications/publications?authid=12834807
RCSB PDB - 1LJM: DNA recognition is mediated by conformational transition and by DNA bending Macromolecule...RCSB PDB - 1LJM: DNA recognition is mediated by conformational transition and by DNA bending Macromolecule...
1LJM: DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending.
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1LJM
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CBFA2T2CBFA2T2
"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ...
https://en.wikipedia.org/wiki/CBFA2T2
CBFA2T3CBFA2T3
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...
https://en.wikipedia.org/wiki/CBFA2T3
RUNX2RUNX2
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. The Runx2 DNA-binding activity is correlated with ...
https://en.wikipedia.org/wiki/RUNX2
RNA polymeraseRNA polymerase
... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β': The β' subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...
https://en.wikipedia.org/wiki/RNA_polymerase
Runt domainRunt domain
... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ... In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has ...
https://en.wikipedia.org/wiki/Runt_domain
RUNX1RUNX1
... or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. RUNX1 is a ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...
https://en.wikipedia.org/wiki/RUNX1
TAF11TAF11
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 ... The conserved region contains four alpha helices and three loops arranged as in histone H3. TAF11 has been shown to interact ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ...
https://en.wikipedia.org/wiki/TAF11
CBFBCBFB
... it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and ... Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...
https://en.wikipedia.org/wiki/CBFB
Sigma factorSigma factor
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... Sigma factors in E. coli:. *σ70(RpoD) - σA - the "housekeeping" sigma factor or also called as primary sigma factor, ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...
https://en.wikipedia.org/wiki/Sigma-70
Sigma factorSigma factor
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... later showed that the sigma factor does not obligatorily leave the core. Instead, it changes its binding with the core during ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Therefore, the sigma factor, cycles between a strongly bound state during initiation and a weakly bound state during elongation ...
https://en.wikipedia.org/wiki/Sigma_factor
CAAT boxCAAT box
These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... The first domain (A1) contains 20 amino acids that forms an alpha helix that appears significant in its interactions with NF-YB ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...
https://en.wikipedia.org/wiki/CAAT_box
TBP-associated factorTBP-associated factor
Selective factor 1 is composed of the TATA-binding protein and three TAF (TATA box-binding protein-associated factor) subunits ... It contains two short alpha helices and a long central alpha helix. TAF1 (TAFII250) TAF2 (CIF150) TAF3 (TAFII140) TAF4 ( ... for example the downstream promoter element or gene-specific core promoter sequence Due to such interactions, they contribute ... The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a ...
https://en.wikipedia.org/wiki/TBP-associated_factor
GTF2A1LGTF2A1L
This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...
https://en.wikipedia.org/wiki/GTF2A1L
Promoter (genetics)Promoter (genetics)
DNA binding by the alpha subunit of RNA polymerase". Science. 262 (5138): 1407-1413. Bibcode:1993Sci...262.1407R. doi:10.1126/ ... "New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An example is the E-box (sequence CACGTG), which binds transcription factors in the basic helix-loop-helix (bHLH) family (e.g. ...
https://en.wikipedia.org/wiki/Promoter_
Promoter (genetics)Promoter (genetics)
DNA binding by the alpha subunit of RNA polymerase". Science. 262 (5138): 1407-13. Bibcode:1993Sci...262.1407R. doi:10.1126/ ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ...
https://en.wikipedia.org/wiki/Promoter_(genetics)
Histone foldHistone fold
One species that looked at is Drosophila, and in the subunits of the Drosophila transcription initiation factor has specific ... conserved motif found near the C-terminus in every core histone sequence in a histone octamer responsible for the binding of ... The histone fold averages about 70 amino acids and consists of three alpha helices connected by two short, unstructured loops. ... Also the histone fold was first found in TATA box-binding protein-associated factors, which is a main component in ...
https://en.wikipedia.org/wiki/Histone_fold
TAF9TAF9
This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several ... The protein complex that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to ... "Induced alpha helix in the VP16 activation domain upon binding to a human TAF". Science. 277 (5330): 1310-3. doi:10.1126/ ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ...
https://en.wikipedia.org/wiki/TAF9
SEC61BSEC61B
This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...
https://en.wikipedia.org/wiki/SEC61B
CUL4ACUL4A
The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ...
https://en.wikipedia.org/wiki/CUL4A
Sec61 alpha 1Sec61 alpha 1
Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...
https://en.wikipedia.org/wiki/Sec61_alpha_1
ATP-binding cassette transporterATP-binding cassette transporter
... sandwiched between the Walker A and B motifs of one subunit and the LSGGQ motif of the other subunit. The maltose binding ... heme-binding protein, and alkaline protease), heme, hydrolytic enzymes, S-layer proteins, competence factors, toxins, ... In addition, a gap in the protein is accessible directly from the hydrophobic core of the inner leaflet of the membrane bilayer ... The T domains are each built of typically 10 membrane spanning alpha helices, through which the transported substance can cross ...
https://en.wikipedia.org/wiki/ATP-binding_cassette_transporter
EGLN1EGLN1
In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... "Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases". Structure. 17 (7): 981-9. ... The catalytic domain consists of a double-stranded β-helix core that is stabilized by three α-helices packed along the major β- ... X-ray crystallography and NMR spectroscopy showed that both peptides bind to the same binding site on PHD2, in a cleft on the ...
https://en.wikipedia.org/wiki/EGLN1
TAF15TAF15
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a ... This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and ... TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription ...
https://en.wikipedia.org/wiki/TAF15
PSMD10PSMD10
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
https://en.wikipedia.org/wiki/PSMD10
POLR2JPOLR2J
"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599-606. doi:10.1006/jmbi. ... "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655-66. ... The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of ...
https://en.wikipedia.org/wiki/POLR2J
CREB-binding proteinCREB-binding protein
"BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit". The ... Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T (April 2002). "Prothymosin alpha interacts with the CREB-binding ... hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ...
https://en.wikipedia.org/wiki/CREB-binding_protein
EIF-W2 protein domainEIF-W2 protein domain
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... The W2 domain has a globular fold and is exclusively composed out of alpha-helices. ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ...
https://en.wikipedia.org/wiki/EIF-W2_protein_domain
PSMC5PSMC5
"The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative ... which interacts with the seven-membered alpha ring of 20S core particle and eastablishs an asymmetric interface between the 19S ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
https://en.wikipedia.org/wiki/PSMC5
Ars operonArs operon
It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...
https://en.wikipedia.org/wiki/Ars_operon
Cyclin DCyclin D
This contains a core of two compact domains with each having five alpha helices. The first five-helix bundle is a conserved ... Viral cyclin D binds human Cdk6 and inhibits Rb by phosphorylating it, resulting in free transcription factors which result in ... A simplification in yeast is that all cyclins bind to the same Cdc subunit, the Cdc28. Cyclins in yeast are controlled by ... A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast ...
https://en.wikipedia.org/wiki/Cyclin_D
Alkali metalAlkali metal
... caused by the alpha decay of actinium-227.[35] Perey then attempted to determine the proportion of beta decay to alpha decay in ... Gottschlich, Michele M. (2001). The Science and Practice of Nutrition Support: A Case-based Core Curriculum. Kendall Hunt. p. ... The first factor depends on the volume of the atom and thus the atomic radius, which increases going down the group; thus, the ... Solid phenyllithium forms monoclinic crystals can be described as consisting of dimeric Li2(C6H5)2 subunits. The lithium atoms ...
https://en.m.wikipedia.org/wiki/Alkali_metal
Receptor (biochemistry)Receptor (biochemistry)
They are composed of a C-terminal ligand-binding region, a core DNA-binding domain (DBD) and an N-terminal domain that contains ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... The loops connecting the alpha helices form extracellular and intracellular domains. The binding-site for larger peptide ... The N terminus interacts with other cellular transcription factors in a ligand-independent manner; and, depending on these ...
https://en.m.wikipedia.org/wiki/Receptor_
NPM1 - Wikipédia, a enciclopédia livreNPM1 - Wikipédia, a enciclopédia livre
protein kinase binding. • core promoter binding. • RNA polymerase II transcription coactivator activity. • transcription factor ... ribosomal large subunit binding. • protein homodimerization activity. • ribosomal small subunit binding. • unfolded protein ... regulation of eIF2 alpha phosphorylation by dsRNA. • positive regulation of cell cycle G2/M phase transition. • negative ... activating transcription factor binding. • rRNA binding. • protein N-terminus binding. • chromatin binding. ...
https://pt.m.wikipedia.org/wiki/NPM1
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
BDNF is made in the endoplasmic reticulum and secreted from dense-core vesicles. It binds carboxypeptidase E (CPE), and the ... regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits ... receptor binding. • neurotrophin TRKB receptor binding. • growth factor activity. • GO:0001948 protein binding. ... BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor. ...
https://en.wikipedia.org/wiki/BDNF
ProteasomeProteasome
... a 9-subunit base that binds directly to the α ring of the 20S core particle, and a 10-subunit lid. Six of the nine base ... Degradation of Aux/IAA proteins derepresses transcription factors in the auxin-response factor (ARF) family and induces ARF- ... which serve as docking domains for the regulatory particles and the alpha subunits N-termini (Pfam PF10584) form a gate that ... The mechanisms by which it binds to the core particle through the C-terminal tails of its subunits and induces α-ring ...
https://en.m.wikipedia.org/wiki/Proteasome
Aminoacyl tRNA synthetaseAminoacyl tRNA synthetase
The alpha helical anticodon binding domain of Arginyl, Glycyl and Cysteinyl-tRNA synthetases is known as the DALR domain after ... Alignment of the core domains of aminoacyl-tRNA synthetases class I and class II. Essential binding site residues (Backbone ... It aminoacylates at the 3'-OH of a terminal adenosine on tRNA, and is usually dimeric or tetrameric (two or four subunits, ... and an anticodon binding domain (which interacts mostly with the anticodon region of the tRNA and ensures binding of the ...
https://en.wikipedia.org/wiki/Aminoacyl_tRNA_synthetase
ProteinProtein
... s can bind to other proteins as well as to small-molecule substrates. When proteins bind specifically to other copies of ... Kauzmann W (May 1956). "Structural factors in protein denaturation". Journal of Cellular Physiology. 47 (Suppl 1): 113-31. doi: ... Quaternary structure: the structure formed by several protein molecules (polypeptide chains), usually called protein subunits ... The membrane alone has a hydrophobic core through which polar or charged molecules cannot diffuse. Membrane proteins contain ...
https://en.m.wikipedia.org/wiki/Protein_synthesis
Francis CrickFrancis Crick
... the alpha helix). Linus Pauling was the first to identify[29] the 3.6 amino acids per helix turn ratio of the alpha helix. ... It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... In 1960, Crick accepted an honorary fellowship at Churchill College, Cambridge, one factor being that the new college did not ...
https://en.wikipedia.org/wiki/Francis_Crick
CellulaseCellulase
... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity.[12] ... McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-beta-D-glucanase". ... construction of the catalytic core, expression, and X-ray structure at 1.75 Ã… resolution". Biochemistry. 36 (51): 16032-9. doi: ...
https://en.wikipedia.org/wiki/Cellulase
MyofilamentMyofilament
Each tropomyosin molecule has a smaller calcium-binding protein called troponin bound to it. All thin filaments are attached to ... The filaments are organized into repeated subunits along the length of the myofibril. These subunits are called sarcomeres. ... They run through the core of each thick filament and anchor it to the Z-line, the end point of a sarcomere. Titin also ... Troponin and the associated tropomyosin undergo a conformational change after calcium binding and expose the myosin binding ...
https://en.wikipedia.org/wiki/Myofilament
AMPA receptorAMPA receptor
Each AMPAR has four sites to which an agonist (such as glutamate) can bind, one for each subunit.[5] The binding site is ... Armstrong N, Sun Y, Chen GQ, Gouaux E (October 1998). "Structure of a glutamate-receptor ligand-binding core in complex with ... "Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin- ... "Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP ...
https://en.wikipedia.org/wiki/AMPAR
C1QBPC1QBP
This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding ... C1QBP has been shown to interact with Protein kinase D1,[10] BAT2,[11] PRKCD,[10] PKC alpha[10] and Protein kinase Mζ.[10] ... "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation". J Clin ... transcription factor binding. • protein binding. • hyaluronic acid binding. • kininogen binding. • mitochondrial ribosome ...
https://en.wikipedia.org/wiki/C1QBP
Tyrosine hydroxylaseTyrosine hydroxylase
Each subunit consists of three domains. At the carboxyl terminal of the peptide chain there's a short alpha helix domain that ... oxygen binding. • metal ion binding. • dopamine binding. • enzyme binding. • oxidoreductase activity. • iron ion binding. • ... response to growth factor. • response to ethanol. • cellular response to glucose stimulus. • phthalate metabolic process. • ... allows tetramerization.[15] The central ~300 amino acids make up a catalytic core, in which all the residues necessary for ...
https://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase
dnaQdnaQ
... is the gene encoding the ε subunit of DNA polymerase III in Escherichia coli.[1] The ε subunit is one of three core ... of the gene product binds the θ subunit and carries out the exonuclease function and the C-terminus binds the α subunit ... "The proofreading exonuclease subunit epsilon of Escherichia coli DNA polymerase III is tethered to the polymerase subunit alpha ... The ε subunit is stabilized by the θ subunit within the complete polymerase complex.[7] ...
https://en.wikipedia.org/wiki/DnaQ
FOXA2FOXA2
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... 2009). "The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of ... "Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression". J. Mol. ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ...
https://en.wikipedia.org/wiki/FOXA2
IronIron
14 alpha particles) is easily produced from lighter nuclei in the alpha process in nuclear reactions in supernovae (see silicon ... The inner core of the Earth is generally presumed to consist of an iron-nickel alloy with ε (or β) structure.[10] ... Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... The ensuing availability of inexpensive iron was one of the factors leading to the Industrial Revolution. Toward the end of the ...
https://en.m.wikipedia.org/wiki/Iron
Drosophila melanogasterDrosophila melanogaster
InaD contains five binding domains called PDZ domain proteins, which specifically bind the C termini of target proteins. ... Drosophila differentially expresses a core group of 252 genes upon infection with most bacteria. This core group of genes is ... Bakker K (1961). "An analysis of factors which determine success in competition for food among larvae of Drosophila ... A 2016 study concluded that food supplementation with 10-mM alpha-ketoglutarate decreased Drosophila alcohol sensitivity over ...
https://en.wikipedia.org/wiki/Drosophila_melanogaster
Protein kinase AProtein kinase A
The activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the ... crystallised the PKA Cα subunit, which revealed the bi-lobe structure of the protein kinase core for the very first time, ... Long term memory is dependent on the CREB transcription factor, regulated by PKA. A study done on drosophila reported that an ... Two cAMP molecules bind to each PKA regulatory subunit. *The regulatory subunits move out of the active sites of the catalytic ...
https://en.m.wikipedia.org/wiki/Protein_kinase_A
DNA methyltransferaseDNA methyltransferase
In the presence of the R subunit, the complex can also act as an endonuclease, binding to the same target sequence but cutting ... A conserved enzyme core with variable target-recognizing domains". J. Mol. Biol. 206 (2): 305-12. doi:10.1016/0022-2836(89) ... hsdM contains an alpha-helical domain at the N-terminus, the HsdM N-terminal domain.[7] ... The type I restriction and modification system is composed of three polypeptides R, M and S. The M (hsdM) and S subunits ...
https://en.wikipedia.org/wiki/DNA_methyltransferase
Protein metabolismProtein metabolism
For example, a protein called eukaryotic initiation factor-2 (eIF-2) can bind to the smaller subunit of the ribosome, starting ... The two reacting molecules are the alpha amino group of one amino acid and the alpha carboxyl group of the other amino acids. A ... In a hydrophilic environment such as cytosol, the hydrophobic amino acids will concentrate at the core of the protein, while ... These subunits surround the mRNA strand. The larger subunit contains three binding sites: A (aminoacyl), P (peptidyl), and E ( ...
https://en.m.wikipedia.org/wiki/Amino_acid_metabolism
Retinoblastoma proteinRetinoblastoma protein
ubiquitin protein ligase binding. • importin-alpha family protein binding. • disordered domain specific binding. • core ... DNA binding. • core promoter binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... Within each subunit, there are a variety of protein binding sites, as well as a total of 15 possible phosphorylation sites. ... transcription factor binding. • RNA polymerase II activating transcription factor binding. • phosphoprotein binding. • kinase ...
https://en.m.wikipedia.org/wiki/Retinoblastoma_protein
Discovery and development of non-nucleoside reverse-transcriptase inhibitorsDiscovery and development of non-nucleoside reverse-transcriptase inhibitors
An important factor in the binding of the first generation NNRTIs, such as nevirapine, is the butterfly-like shape. Despite ... The cloroindole part interacted with the hydrophobic core of the pocket and influenced the binding mode of the R120393 so it ... Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU)". Bioorganic & Medicinal Chemistry Letters. 11 ... Ã… from the catalytic site in the palm domain of the p66 subunit site of the enzyme. The NNRTI binding pocket (NNIBP) contains ...
https://en.wikipedia.org/wiki/Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors
LipidLipid
Most vegetable oils are rich in linoleic acid (safflower, sunflower, and corn oils). Alpha-linolenic acid is found in the green ... Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227-30 ... The steroids, all derived from the same fused four-ring core structure, have different biological roles as hormones and ... Polyketides are synthesized by polymerization of acetyl and propionyl subunits by classic enzymes as well as iterative and ...
https://en.wikipedia.org/wiki/Lipid
VirusVirus
The same protein may act as the subunit of both the pentamers and hexamers or they may be composed of different proteins.[81]. ... When the adaptive immune system of a vertebrate encounters a virus, it produces specific antibodies that bind to the virus and ... Counting these areas and multiplying by the dilution factor allowed him to calculate the number of viruses in the original ... Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: The ...
https://en.wikipedia.org/wiki/Virus_structure
HMGA1HMGA1
0001204 DNA-binding transcription factor activity. • 5'-deoxyribose-5-phosphate lyase activity. • transcription factor binding ... "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y ... core motif, a novel cross-linking domain located between the second and third AT-hook, and a C-terminal acidic tail ... "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions ...
https://en.wikipedia.org/wiki/HMGA1
Respiratory complex IRespiratory complex I
Assembly factor proteins[31] 47. NDUFAF1c. CIA30_HUMAN. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 1. ... Core Subunitsa 1. NDUFS7 / PSST / NUKM. NDUS7_HUMAN. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial EC ... Complex I contains a ubiquinone binding pocket at the interface of the 49-kDa and PSST subunits. Close to iron-sulfur cluster ... 1 alpha subcomplex subunit 3. Pfam PF14987 39. NDUFA4 / MLRQc. NDUA4_HUMAN. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex ...
https://en.wikipedia.org/wiki/NADH_dehydrogenase_
Alpha helixAlpha helix
Zipper Coiled-Coil Domains of the cGMP-Dependent Protein Kinase I alpha and its Interaction with the Myosin Binding Subunit of ... Leucine zipper coiled-coil helices & DNA-binding helices: transcription factor Max (PDB file 1HLO) ... in the hydrophobic core, and one containing predominantly polar amino acids oriented toward the solvent-exposed surface of the ... DNA bindingEdit. α-Helices have particular significance in DNA binding motifs, including helix-turn-helix motifs, leucine ...
https://en.m.wikipedia.org/wiki/Alpha_helix
AminoglycosideAminoglycoside
X-ray crystallographic structure of the 30S ribosomal subunit with bound drug (purple, space-filling model, at center) protein ... Volume 1. Core Clinical Skills. Oxford University Press. 2010. *^ referenced in Treatment of Mitochodrial Disease: Bindu LH, ... PubMed:19031229] See Also Fischel-Ghodsian N. Genetic factors in aminoglycoside toxicity. Ann NY Acad Sci. 1999; 884:99-109. [ ... secondary structure elements such as alpha-helices in bright green, and the RNA phosphodiester backbone shown in orange (and ...
https://en.m.wikipedia.org/wiki/Aminoglycoside
Core-binding factor, runt domain, alpha subunit 1 | definition of core-binding factor, runt domain, alpha subunit 1 by Medical...Core-binding factor, runt domain, alpha subunit 1 | definition of core-binding factor, runt domain, alpha subunit 1 by Medical...
What is core-binding factor, runt domain, alpha subunit 1? Meaning of core-binding factor, runt domain, alpha subunit 1 medical ... alpha subunit 1 in the Medical Dictionary? core-binding factor, runt domain, alpha subunit 1 explanation free. ... What does core-binding factor, runt domain, alpha subunit 1 mean? ... Looking for online definition of core-binding factor, runt ... Core-binding factor, runt domain, alpha subunit 1 , definition of core-binding factor, runt domain, alpha subunit 1 by Medical ...
https://medical-dictionary.thefreedictionary.com/core-binding+factor%2C+runt+domain%2C+alpha+subunit+1
Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), transcript...Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), transcript...
... alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), transcript variant 2, (10ug), 10 µg. ... Home » cDNA » Mouse cDNA » Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 ( ... MC219266 Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), ... Properties for Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) ( ...
https://www.acris-antibodies.com/cdna/mouse-cdna/cbfa2t3-untagged-mouse-core-binding-factor-runt-domain-alpha-subunit-2-translocated-to-3-human-cbfa2t3-transcript-variant-2-10ug-mc219266.htm
Temat: Core Binding Factor Alpha 2 Subunit - OpacWWW - Prolib IntegroTemat: 'Core Binding Factor Alpha 2 Subunit' - OpacWWW - Prolib Integro
Core. Binding. Factor. Alpha. 2. Subunit. /*genetics Core. Binding. Factor. Alpha. 3 Subunit. /*genetics Precursor Cells, T- ... Core. Binding. Factor. Alpha. 2. Subunit. /deficiency ; Core. Binding. Factor. Alpha. 2. Subunit. /genetics ; Gene Knock-In ... Core. Binding. Factor. Alpha. 2. Subunit. /immunology ; Core. Binding. Factor. Alpha. 3 Subunit. /immunology ; Female ; Gene ... Core. Binding. Factor. Alpha. 2. Subunit. /*genetics DNA-. Binding. Proteins/*genetics Guanine Nucleotide Exchange Factors/* ...
https://katalog.ue.wroc.pl/eds/search?q=%22Core+Binding+Factor+Alpha+2+Subunit%22&index=4
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...
Core Binding Factor alpha Subunits/genetics*. *Embryonal Carcinoma Stem Cells*. *Evolution, Molecular ... Purification and cDNA cloning revealed that PEBP2 has two subunits, DNA-binding alpha (PEBP2alpha) and non-DNA-binding beta ( ... Core-binding factor (CBF), which interacts with a murine retrovirus enhancer, was found to be identical to PEBP2. runt, ... Transcription factors PEA1/AP1, PEA2/PEBP2, and PEA3/ETS were identified as A element-binding proteins. All of them are absent ...
https://www.ncbi.nlm.nih.gov/pubmed/18037406?dopt=Abstract
Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. - PubMed - NCBIHematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. - PubMed - NCBI
Core Binding Factor alpha Subunits/genetics. *Core Binding Factor alpha Subunits/metabolism ... Core Binding Factor alpha Subunits. Secondary source ID. *GEO/GSE56015. Grant support. *U01HL100405/HL/NHLBI NIH HHS/United ...
https://www.ncbi.nlm.nih.gov/pubmed/25594182?dopt=Abstract
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceRUNX proteins in transcription factor networks that regulate T-cell lineage choice
RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. In this ... Recent research has uncovered complex transcription factor networks that control the processes of T-cell development and ... Core Binding Factor alpha Subunits / genetics * Core Binding Factor alpha Subunits / metabolism* ... RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. In this ...
https://pubmed.ncbi.nlm.nih.gov/19165227/?dopt=Abstract
Mutations in the RUNX2 gene in patients with cleidocranial dysplasiaMutations in the RUNX2 gene in patients with cleidocranial dysplasia
Core Binding Factor Alpha 1 Subunit * Core Binding Factor alpha Subunits * Neoplasm Proteins ... Core Binding Factor Alpha 1 Subunit * Core Binding Factor alpha Subunits * Humans ... RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a ... However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction ...
https://pubmed.ncbi.nlm.nih.gov/11857736/?dopt=Abstract
RUNX1T1 gene: MedlinePlus GeneticsRUNX1T1 gene: MedlinePlus Genetics
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related ... The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). As part of CBF ... Core binding factor acute myeloid leukemia. A rearrangement (translocation) of genetic material involving the RUNX1T1 gene is ... Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2): ...
https://medlineplus.gov/genetics/gene/runx1t1/
RUNX2 gene: MedlinePlus GeneticsRUNX2 gene: MedlinePlus Genetics
SL3-3 enhancer factor 1 alpha A subunit. *SL3/AKV core-binding factor alpha A subunit ... The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the ...
https://medlineplus.gov/genetics/gene/runx2/
Runx3 - Runt-related transcription factor 3 - Mus musculus (Mouse) - Runx3 gene & proteinRunx3 - Runt-related transcription factor 3 - Mus musculus (Mouse) - Runx3 gene & protein
... while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of ... The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus ... CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding ... RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5-TGTGGT ...
https://www.uniprot.org/uniprot/Q64131
Recombinant Human RUNX1 / AML1 protein (ab112260) | AbcamRecombinant Human RUNX1 / AML1 protein (ab112260) | Abcam
SL3/AKV core binding factor alpha B subunit. *SL3/AKV core-binding factor alpha B subunit ... Core binding factor alpha 2 subunit. *Core binding factor runt domain alpha subunit 2 ... The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes ... CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ...
https://www.abcam.com/recombinant-human-runx1-aml1-protein-ab112260.html?accordion=Documents
Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental...Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental...
... core-binding factor alpha subunit 1 (Cbfa1; 7.2-fold), osteocalcin (OC; 430-fold), and BSP (BSP; 5.7-fold) transcripts (Fig. 1 ... B and C) Newly formed vessels, identified by CD31+ endothelial cells, penetrated the outer matrix and reached the inner core in ... an inner hypertrophic core (B, D, and F) rich in GAG, Col II, and Col X, and an outer mineralized rim (B, H, J, and L) with a ... 1997) Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. ...
https://www.pnas.org/content/107/16/7251?ijkey=cc69a45ac0e8341f2d8a4f46dc54319290c86c42&keytype2=tf_ipsecsha
REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studiesREGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies
Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (Predicted). ... PREDICTED: transcription initiation factor TFIID subunit 4-like[Cricetulus griseus].. 11. Mus musculus. 12396. Cbfa2t2; ... PREDICTED: transcription initiation factor TFIID subunit 4B-like[Cricetulus griseus].. 10. Cricetulus griseus. 100769929. ... PREDICTED: transcription initiation factor TFIID subunit 4-likeisoform 1 [Bombus impatiens].. 31. Pteropus vampyrus. ...
http://www.bioinformatics.org/regulator/page.php?act=list_t&acc=PF07531
CBFA2T2 - WikipediaCBFA2T2 - Wikipedia
"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ...
https://en.wikipedia.org/wiki/CBFA2T2
CBFA2T3 - WikipediaCBFA2T3 - Wikipedia
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...
https://en.wikipedia.org/wiki/CBFA2T3
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
0 (BMP2 protein, human); 0 (Bone Morphogenetic Protein 2); 0 (Core Binding Factor Alpha 1 Subunit); 0 (Drugs, Chinese Herbal); ... Subunidade alfa 1 de Fator de Liga o ao Core/gen tica. Seres Humanos. Sistema de Sinaliza o das MAP Quinases/efeitos dos f ... 0 (Enzyme Inhibitors); EC 3.2.1.1 (alpha-Amylases); EC 3.4.21.62 (Subtilisin). ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=B01.650.940.800.575.912.250.075.511
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
0 (Core Binding Factor Alpha 1 Subunit); 0 (Glycation End Products, Advanced); 0 (Reactive Oxygen Species); 0 (Thiophenes); ... 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); ... Subunidade alfa 1 de Fator de Liga o ao Core/metabolismo. Masculino. Modelos Biol gicos. Mi citos de M sculo Liso/efeitos dos f ... Factors affecting recurrence were also examined. RESULTS: A total of 5695 UC patients were registered. Among the 4677 patients ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D02.065.884.730
CBFA2/RUNX1 translocation partner 2 ELISA Kits | Biocompare.comCBFA2/RUNX1 translocation partner 2 ELISA Kits | Biocompare.com
Core Binding Factor Alpha Subunit 2 Translocated To 2 (. *. Detection Range: 0.313 ng/ml - 20 ng/ml ... Background: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a rational target... read more ...
https://www.biocompare.com/pfu/110627/soids/2-2265190/ELISA_Kit/ELISA_CBFA2RUNX1_translocation_partner_2
CBFA2T2 Gene - GeneCards | MTG8R Protein | MTG8R AntibodyCBFA2T2 Gene - GeneCards | MTG8R Protein | MTG8R Antibody
core binding factor Runt domain,alpha subunit 2,(RUNX1) translocated to 2,mainly expressed in brain,with several isoforms due ... Core-binding factor, runt domain, alpha subunit 2; translocated to, 2:. *Hs.153934 ... Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2 2 3 ... Transcription Factor. Binding Sites. Gene Targets. GH20J033488. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE 666.8. 0.0. -23. ...
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CBFA2T2
CBFA2T2 Gene - GeneCards | MTG8R Protein | MTG8R AntibodyCBFA2T2 Gene - GeneCards | MTG8R Protein | MTG8R Antibody
core binding factor Runt domain,alpha subunit 2,(RUNX1) translocated to 2,mainly expressed in brain,with several isoforms due ... Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2 2 3 ... Transcription Factor. Binding Sites. Gene Targets. GH20J033400. Promoter/Enhancer. 2.1. EPDnew Ensembl ENCODE CraniofacialAtlas ... Top Transcription factor binding sites by QIAGEN in the CBFA2T2 gene promoter:. *Brachyury ...
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CBFA2T2&keywords=GH20J033476&prefilter=genomic_location
core binding factor alpha Summary Report | CureHuntercore binding factor alpha Summary Report | CureHunter
... core binding factor plays a key role in several development pathways and in human disease; has been sequenced ... Transcription Factors: 20597*Core Binding Factors: 223*Core Binding Factor alpha Subunits: 18*core binding factor alpha: 16 ... core binding factor alpha. Subscribe to New Research on core binding factor alpha ... 11/07/2000 - "Binding of CBFalpha/AML/PEBP2alpha (core binding factor alpha/acute myelogenous leukemia/polyoma enhancer binding ...
http://www.curehunter.com/public/keywordSummaryC406688-core-binding-factor-alpha.do
Osteo-Promoter Database (OPD) - Promoter analysis in skeletal cells | BMC Genomics | Full TextOsteo-Promoter Database (OPD) - Promoter analysis in skeletal cells | BMC Genomics | Full Text
The analysis leads to a better insight of proteins that bind to DNA, regulate DNA, and function in chromatin remodeling. The ... The study summarizes transcriptional regulation factors interacting and cooperating at promoter regions that regulate gene ... Core-binding factor alpha-subunit 1. Osteoblast-specific transcription factor. Cleidocranial dysplasia murine Cbfa1+/- ... Transcription factors bind to regulatory elements upstream of transcription start sites and interact with other factors to ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-6-46
Arumugam Balasubramanian, Ph.D. | Harvard Catalyst Profiles | Harvard CatalystArumugam Balasubramanian, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Core Binding Factor Alpha 1 Subunit. Enzyme Induction. Okadaic Acid. Bone Remodeling. Mesenchymal Stem Cells. Osteoblasts. ... Transforming Growth Factor beta1. Down-Regulation. Up-Regulation. 3 Untranslated Regions. Activating Transcription Factor 3. ... Core Binding Factor Alpha 1 Subunit. 3. 2015. 2018. March 2017. Enzyme Induction. 1. 2017. 2017. May 2017. ... Core Binding Factor Alpha 1 Subunit * Matrix Metalloproteinase 13 * Transforming Growth Factor beta1 ...
https://connects.catalyst.harvard.edu/Profiles/display/person/176345/network/researchareas/timeline
RUNX3/CBFA3 Antibody (2B10E8) [DyLight 488] (NBP2-22391G): Novus BiologicalsRUNX3/CBFA3 Antibody (2B10E8) [DyLight 488] (NBP2-22391G): Novus Biologicals
AML2SL3/AKV core-binding factor alpha C subunit. *CBFA3. *CBFA3MGC16070. *CBF-alpha-3 ...
https://www.novusbio.com/products/runx3-cbfa3-antibody-2b10e8_nbp2-22391g
RUNX3/CBFA3 Antibody (2B10E8) [Biotin] (NBP2-22391B): Novus BiologicalsRUNX3/CBFA3 Antibody (2B10E8) [Biotin] (NBP2-22391B): Novus Biologicals
AML2SL3/AKV core-binding factor alpha C subunit. *CBFA3. *CBFA3MGC16070. *CBF-alpha-3 ...
https://www.novusbio.com/products/runx3-cbfa3-antibody-2b10e8_nbp2-22391b
TCF3 | Cancer Genetics WebTCF3 | Cancer Genetics Web
Core Binding Factor Alpha 2 Subunit. *MicroRNAs. *DNA-Binding Proteins. *FISH. *TCF3 ... bHLH transcription factor binding - cell development - chromatin binding - cytoplasm - DNA binding - E-box binding - G1 phase ... transcription factor binding - transcription factor complex - transcription regulatory region DNA binding - transcription, DNA- ... sequence-specific DNA binding - sequence-specific DNA binding transcription factor activity - T cell differentiation in thymus ...
http://www.cancerindex.org/geneweb/TCF3.htm
RUNX1 Antibody (710233) RUNX1 Antibody (710233)
CBF-alpha-2; core binding factor alpha 2; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit ... SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; transcription factor ... Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; Runt-related transcription factor ... DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding transcription factor binding ...
https://www.thermofisher.com/antibody/product/RUNX1-Antibody-Recombinant-Polyclonal/710233
Prosthetic rehabilitation of a patient with cleidocranial dysplasia using dental implants-a clinical report | SpringerLinkProsthetic rehabilitation of a patient with cleidocranial dysplasia using dental implants-a clinical report | SpringerLink
Core-binding factor subunit alpha-1. FDP:. Fixed dental prostheses. RUNX2:. Runt-related transcription factor 2 ... a transcription factor on chromosome 6p21, have been identified as the cause [3]. This transcription factor is responsible for ... factors such as risk of chipping, esthetics [34], and costs must be weighed. In this case, no ceramic-veneered FDPs were ...
https://rd.springer.com/article/10.1186/s40729-020-00287-7?error=cookies_not_supported&code=00d7910a-68c3-451e-b46d-e0572bc280bd
Calcium Amino Acid Chelate (Bottle Package)Calcium Amino Acid Chelate (Bottle Package)
Adenovirus with ORF of core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3), transcript variant 2 ... Adenovirus with ORF of core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2), transcript variant 4 ... Adenovirus with ORF of core-binding factor, beta subunit (CBFB), transcript variant 2 with C terminal Flag and His tag. ... Adenovirus with ORF of interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40 ...
http://trademetro.net/catalog/Medical-Health-&-Beauty-12.html?catid=12&order=catname&way=1
Anti-RUNX1T1/ETO/CDR antibody - ChIP Grade (ab195329) | AbcamAnti-RUNX1T1/ETO/CDR antibody - ChIP Grade (ab195329) | Abcam
Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related antibody ... Core binding factor runt domain alpha subunit 2 translocated to 1 antibody ... Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress ... Runt related transcription factor 1 translocated to 1 antibody. *Runt related transcription factor 1 translocated to 1 cyclin D ...
https://www.abcam.com/runx1t1etocdr-antibody-chip-grade-ab195329.html
ProteinsRUNX2GenesGeneRUNX1CBFBInitiationPEBP2AcutePromoterRunt-related transcription factorRUNXPromotersHomologRegulatoryHomologousFamily of transcription factorsHistone deacetylasesRegulationTranscriptionalPolymerase II coreMeSHBetaHeterodimeric transcriptionCell differentiationReceptorDifferentiationEnhancesAttachesEukaryoticMRNASigmaOsteoblastsSequence-specificCBFA1PMIDIntegrin
Proteins23
  • Transcription factors PEA1/AP1, PEA2/PEBP2, and PEA3/ETS were identified as A element-binding proteins. (nih.gov)
  • RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. (nih.gov)
  • However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction with DNA, as well as the cofactor CBFB, start to provide an insight into how missense mutations affect RUNX2 function. (nih.gov)
  • It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. (medlineplus.gov)
  • Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. (medlineplus.gov)
  • The analysis leads to a better insight of proteins that bind to DNA, regulate DNA, and function in chromatin remodeling. (biomedcentral.com)
  • Genes in eukaryotic cells are regulated in "active regions," in which chromatin structure is "open" and accessible to DNA-binding proteins and "silent regions" where "packed" chromatin renders the DNA inaccessible. (biomedcentral.com)
  • An important motif presented in the promoter is an A/T-rich region that binds proteins with an A/T-hook motif. (biomedcentral.com)
  • RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. (thermofisher.com)
  • E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. (cancerindex.org)
  • The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. (ebi.ac.uk)
  • This entry represents the conserved amino terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria (TFE) that are also presumed to be TFIIE-alpha subunits [ PMID: 9389475 ]. (ebi.ac.uk)
  • The proteins that guide RNA polymerase to genes are the sigma factors. (wikibooks.org)
  • The specificity of tissue-restricted gene therapy can be refined by utilization of a 31-amino-acid segment of the hematopoietic and osteogenic AML/CBF transcription factors that direct the regulatory proteins to subnuclear sites that support gene expression. (umassmed.edu)
  • Sequences that support the intranuclear trafficking of AML/CBF transcription factors to subnuclear sites that support transcription were determined by the expression and visualization of mutated and epitope tagged AML/CBF proteins. (umassmed.edu)
  • Nuclear proteins that are localized in discrete domains within the nucleus include the leukemia-associated acute myelogenous leukemia (AML) and promyelocytic leukemia (PML) factors, the SC-35 RNA-processing factors, nucleolar proteins and components of both transcriptional and DNA replication complexes. (umassmed.edu)
  • These proteins are collectively referred to as type II DNA-binding proteins (DBPII), forming a group of basic, dimeric proteins found in all bacteria that are able to bind DNA to induce and stabilise DNA bending. (ebi.ac.uk)
  • This blocks N-CoR/SMRT binding by these fusion proteins, and disrupts the repressor protein complex. (elsevier.com)
  • Cytoplasmic calcium acts as a signal by binding to high-affinity calcium-binding proteins. (springer.com)
  • An important subset of these intracellular calcium-binding proteins are proteins that also interact with membranes in a calcium-regulated fashion. (springer.com)
  • Creutz CE, Tomsig JL, Snyder SL, Skouri F, Beisson J, Cohen J. The copines: a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. (springer.com)
  • Copines: a ubiquitous family of Calcium-dependent, phospholipid-binding proteins. (springer.com)
  • RUNX proteins are evolutionarily conserved transcription factors known to be involved in various developmental processes. (elsevier.com)
RUNX216
  • RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. (thefreedictionary.com)
  • RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a subset of chondrocytes. (nih.gov)
  • The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway. (jax.org)
  • Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. (jax.org)
  • In previous studies by our group, we reported that thymosin beta 4 (Tb4) is closely associated with the initiation and development of the tooth germ, and can induce the expression of runt-related transcription factor 2 (RUNX2) during the development of the tooth germ. (nih.gov)
  • Schematic illustration of the putative signaling pathways from thymosin beta 4 (Tb4) to runt-related transcription factor 2 (RUNX2) in the mDE6 cells. (nih.gov)
  • RUNX2 can upregulate the expression of downstream biological effectors, including odontogenesis-related genes and calcification-related factors. (nih.gov)
  • MBS934869 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the runt-related transcription factor 2 (RUNX2) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Standards and samples are pipetted into the wells and any RUNX2 present is bound by the immobilized antibody. (mybiosource.com)
  • Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of RUNX2 bound in the initial step. (mybiosource.com)
  • Here we show that the endogenous Yes-associated protein (YAP), a mediator of Src/Yes signaling, interacts with the native Runx2 protein, an osteoblast-related transcription factor, and suppresses Runx2 transcriptional activity in a dose-dependent manner. (elsevier.com)
  • The aim of this study was to determine if DNA polymorphism within runt-related gene 2 (RUNX2)/core binding factor A1 (CBFA1) is related to bone mineral density (BMD). (cdc.gov)
  • Osteoblast differentiation is controlled by main bone specific transcription factors including Osterix, distal-less homeobox 5 (Dlx5), and Runt-related transcription factor 2 (Runx2). (elsevier.com)
  • The deletion or mutation of the Dlx5 and Runx2 binding sites significantly suppressed Osterix promoter activity in shPP2A cells. (elsevier.com)
  • These results indicate that Dlx5 and Runx2 are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells. (elsevier.com)
Genes12
  • RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (uniprot.org)
  • One of the genes that encodes a CBF alpha subunit is AML1, also called Cbf alpha 2. (curehunter.com)
  • Mammalian CBFB encodes a transcription factor (CBFbeta) that in combination with CBFalpha2 binds to specific DNA sequences and regulates expression of a number of hematopoietic genes. (zfin.org)
  • Point mutations introduced into the core site significantly shifted the disease specificity of the Moloney virus from thymic leukemia to erythroid leukemia (N.A. Speck, B. Renjifo, E. Golemis, T.N. Fredrickson, J.W. Hartley, and N. Hopkins, Genes Dev. (asm.org)
  • Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (harvard.edu)
  • To identify genes whose expressions in primary human trabecular meshwork (TM) cell cultures are affected by the transcription factor pituitary homeobox 2 (PITX2) and to identify genes that may have roles in glaucoma. (molvis.org)
  • The five genes were DIRAS3 (DIRAS family, GTP-binding RAS-like 3), CXCL6 (chemokine (C-X-C motif) ligand 6), SAMD5 (sterile alpha motif domain containing 5), CBFB (core-binding factor, beta subunit), and MEIS2 (meis homeobox 2). (molvis.org)
  • Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. (elsevier.com)
  • These specialized sigma factors bind the promoters of genes appropriate to the environmental conditions, increasing the transcription of those genes. (wikipedia.org)
  • σ 70 (RpoD) - σ A - the "housekeeping" sigma factor or also called as primary sigma factor , transcribes most genes in growing cells. (wikipedia.org)
  • Every cell has a "housekeeping" sigma factor that keeps essential genes and pathways operating. (wikipedia.org)
  • These transcription factors regulate a host of genes specific to haematopoiesis (e.g. (diagenode.com)
Gene22
  • A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. (thefreedictionary.com)
  • The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). (medlineplus.gov)
  • The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. (wikipedia.org)
  • Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity . (genecards.org)
  • A common chromosomal translocation in acute myeloid leukemia (AML) involves the AML1 (acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBF alpha), and PEBP2 alpha B) gene on chromosome 21 and the ETO (eight-twenty one, also called MTG8) gene on chromosome 8. (curehunter.com)
  • Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus. (wikipedia.org)
  • The study summarizes transcriptional regulation factors interacting and cooperating at promoter regions that regulate gene expression. (biomedcentral.com)
  • The knowledge evolve transcription factor binding sites on the promoter will allow the creation of the regulation map of each gene and will enable the recognition of other transcription regulation systems that control gene expression. (biomedcentral.com)
  • This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. (cancerindex.org)
  • PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. (jax.org)
  • Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. (harvard.edu)
  • They also help core RNA polymerase locate the consensus promoter sequences near the beginning of a gene. (wikibooks.org)
  • The subnuclear organization of nucleic acids and cognate regulatory factors suggests that there are functional interrelationships between nuclear structure and gene expression. (umassmed.edu)
  • Mechanisms that control the spatial distribution of transcription factors within the three-dimensional context of the nucleus may involve the sorting of regulatory information, as well as contribute to the assembly and activity of sites that support gene expression. (umassmed.edu)
  • Gene rearrangements that remove or alter intranuclear-targeting signals are prevalent in leukemias and have been linked to altered localization of regulatory factors within the nucleus. (umassmed.edu)
  • These modifications in the intranuclear targeting of transcription factors might abrogate fidelity of gene expression in tumor cells by influencing the spatial organization and/or assembly of machineries involved in the synthesis and processing of gene transcripts. (umassmed.edu)
  • The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. (genetex.com)
  • RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. (antibodies-online.com)
  • transcription factors directly up-regulate P2X3 gene transcription. (genscript.com)
  • RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (acris-antibodies.com)
  • [1] It is a bacterial transcription initiation factor that enables specific binding of RNA polymerase to gene promoters . (wikipedia.org)
  • [2] The specific sigma factor used to initiate transcription of a given gene will vary, depending on the gene and on the environmental signals needed to initiate transcription of that gene. (wikipedia.org)
RUNX16
  • runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl, and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche. (zfin.org)
  • Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium. (genetex.com)
  • the AML1 (show RUNX1 Antibodies )- ETO fusion protein increases the expression of SIRT1 (show SIRT1 Antibodies ), possibly by binding to the promoter region of SIRT1 (show SIRT1 Antibodies ) to activate its transcription in t(8;21) AML (show RUNX1 Antibodies ). (antibodies-online.com)
  • Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. (genscript.com)
  • Web-based predictions of transcription factor binding revealed a binding site for runt-related transcription factor 1 (RUNX1), when the allele at the center of the palindrome (TGGGG(A/G)CCCCA) was A but not when it was G. Furthermore, electromobility shift assay (EMSA) presented evidence in support of allele-specific binding of RUNX1 to 5'HS4. (cdc.gov)
  • Here we show that the mouse transcription factor Runx1, a key regulator of myeloid cell proliferation and differentiation, is expressed in forebrain amoeboid microglia during the first two postnatal weeks. (unboundmedicine.com)
CBFB5
  • Forms the heterodimeric complex core-binding factor (CBF) with CBFB. (uniprot.org)
  • Adenovirus with ORF of core-binding factor, beta subunit (CBFB), transcript variant 2 with C terminal Flag and His tag. (trademetro.net)
  • We have also analyzed the expression of scl and gata-1 in the same hematopoietic mutants to ascertain the relative order of these transcription factors to cbfb in zebrafish hematopoiesis. (zfin.org)
  • Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein. (diagenode.com)
  • CBFb (UniProtKB/Swiss-Prot entry Q13951) represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. (diagenode.com)
Initiation9
  • PREDICTED: transcription initiation factor TFIID subunit 4B-like[Cricetulus griseus]. (bioinformatics.org)
  • PREDICTED: transcription initiation factor TFIID subunit 4-likeisoform 1 [Bombus impatiens]. (bioinformatics.org)
  • Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. (ebi.ac.uk)
  • TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. (ebi.ac.uk)
  • The first would be the initiation step, during which the RNA polymerase II (RNAPII) binds to the DNA site in order to form a preinitiation complex with other transcriptional factors. (wikibooks.org)
  • EMDB-12611: RNA polymerase II core pre-initiation complex with closed promote. (pdbj.org)
  • Transcription factor TFIIE beta subunit, DNA-binding domain / TFA2 Winged helix domain 2 / TFA2, Winged helix domain 2 / TFIIE beta subunit core domain / Transcription initiation factor TFIIE, beta subunit / TFIIEalpha/SarR/Rpc3 HTH domain / TFE/IIEalpha-type HTH domain profile. (pdbj.org)
  • A sigma factor ( σ factor ) is a protein needed only for initiation of transcription. (wikipedia.org)
  • Once initiation of RNA transcription is complete, the sigma factor can leave the complex. (wikipedia.org)
PEBP23
  • Purification and cDNA cloning revealed that PEBP2 has two subunits, DNA-binding alpha (PEBP2alpha) and non-DNA-binding beta (PEBP2beta). (nih.gov)
  • Core-binding factor (CBF), which interacts with a murine retrovirus enhancer, was found to be identical to PEBP2. (nih.gov)
  • Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. (jax.org)
Acute5
  • Comparison of therapy-related and de novo core binding factor acute myeloid leukemia: A bone marrow pathology group study. (harvard.edu)
  • Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit). (harvard.edu)
  • Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia-results of the AMLSG 11-08 trial. (harvard.edu)
  • Dasatinib in high-risk core binding factor acute myeloid leukemia in first complete remission: a French Acute Myeloid Leukemia Intergroup trial. (harvard.edu)
  • Population-based disparities in survival among patients with core-binding factor acute myeloid leukemia: a SEER database analysis. (harvard.edu)
Promoter5
  • Transcriptional regulation factors interacting and cooperating at promoter regions determine the fate of cells and their function. (biomedcentral.com)
  • A sigma factors binds RNA polymerase through the alpha subunit and then helps the core enzyme detect or a recognize a specific DNA sequence, this is called a promoter. (wikibooks.org)
  • A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a promoter region before RNAP can initiate the DNA unwinding at that position. (wikipedia.org)
  • The chromatin immunoprecipitation (ChIP) assay was used to assess the direct binding of HIF1α to the Smad7 promoter. (springernature.com)
  • We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. (tmc.edu)
Runt-related transcription factor1
  • Title: Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells. (genscript.com)
RUNX2
  • In this Review, we examine the mechanisms by which RUNX complexes act together with other transcription factors, such as Th-POK (T-helper-inducing POZ/Kruppel-like factor) and GATA-binding protein 3 (GATA3) in determining the CD4/CD8 lineage choice of developing thymocytes. (nih.gov)
  • They consist of a DNA binding Runx subunit and a non-DNA binding CBFβ sub-unit. (dartmouth.edu)
Promoters4
  • The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). (uniprot.org)
  • Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. (genetex.com)
  • Selection of promoters by RNA polymerase is dependent on the sigma factor that associates with it. (wikipedia.org)
  • The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. (diagenode.com)
Homolog1
  • Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 ( ARF19 ), a transcription factor involved in cell differentiation. (plantcell.org)
Regulatory1
  • Molecular, cellular, genetic and biochemical approaches have identified distinct protein segments, termed intranuclear-targeting signals, that are responsible for directing regulatory factors to specific subnuclear sites. (umassmed.edu)
Homologous1
  • It is homologous to archaeal transcription factor B and to eukaryotic TFIIB . (wikipedia.org)
Family of transcription factors2
  • A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. (bvsalud.org)
  • ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and maintenance of normal hematopoietic stem cells. (diagenode.com)
Histone deacetylases1
  • Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. (abcam.com)
Regulation1
  • Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. (springer.com)
Transcriptional1
  • Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). (genecards.org)
Polymerase II core1
MeSH1
  • Core Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Beta10
  • In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit ( IPR002853 ) and the small beta ( IPR003166 ). (ebi.ac.uk)
  • The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [ PMID: 10716934 ]. (ebi.ac.uk)
  • CBF beta p22.0, CBF beta p21.5, and CBF beta p17.6 do not by themselves bind the core site. (asm.org)
  • However, CBF beta p22.0 and CBF beta p21.5 form a complex with DNA-binding CBF alpha subunits and as a result decrease the rate of dissociation of the CBF protein-DNA complex. (asm.org)
  • Association of the CBF beta subunits does not extend the phosphate contacts in the binding site. (asm.org)
  • We propose that CBF beta is a non-DNA-binding subunit of CBF and does not contact DNA directly. (asm.org)
  • Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. (harvard.edu)
  • Transcription factor TFIIE alpha subunit, C-terminal / C-terminal general transcription factor TFIIE alpha / TFIIE beta central core DNA-binding domain profile. (pdbj.org)
  • The core structure of IHF consists of a partly opened 4-helical bundle that is capped with a beta-sheet. (ebi.ac.uk)
  • RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa , a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
Heterodimeric transcription1
  • Core binding factors are heterodimeric transcription factors involved in diverse developmental processes. (dartmouth.edu)
Cell differentiation1
  • We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19 , which is involved in promoting cell differentiation and thus root growth. (plantcell.org)
Receptor2
  • Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. (asm.org)
  • CBF binds to core sites in murine leukemia virus and T-cell receptor enhancers. (asm.org)
Differentiation2
  • Recent research has uncovered complex transcription factor networks that control the processes of T-cell development and differentiation. (nih.gov)
  • This transcription factor is responsible for the differentiation of precursor cells into osteoblasts and regulates the differentiation of chondrocytes in the growth plate [ 4 ]. (springer.com)
Enhances1
  • In biochemical analyses, cbfbeta binds to human CBFalpha2 and enhances its DNA binding. (zfin.org)
Attaches1
  • When the cell wants to transcribe the DNA strand, the "TATA binding protein" (transcription factor) attaches to the TATA box and subsequently helps in getting the RNA polymerase to attach there and begin synthesizing the RNA. (wikibooks.org)
Eukaryotic2
  • [2] Eukaryotic and archaeal RNAPs have more subunits than bacterial ones do, and are controlled differently. (wikipedia.org)
  • [6] Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits. (wikipedia.org)
MRNA1
  • After a week,the expressions of alkaline phosphatase, Cbf(alpha)l and type I collagen mRNA were detected. (bvsalud.org)
Sigma12
  • A single bacteria species can also make several different sigma factors. (wikibooks.org)
  • A sigma (σ) factor binds to the core, forming the holoenzyme. (wikipedia.org)
  • Every molecule of RNA polymerase holoenzyme contains exactly one sigma factor subunit, which in the model bacterium Escherichia coli is one of those listed below. (wikipedia.org)
  • The number of sigma factors varies between bacterial species. (wikipedia.org)
  • [1] [4] E. coli has seven sigma factors. (wikipedia.org)
  • Sigma factors are distinguished by their characteristic molecular weights. (wikipedia.org)
  • For example, σ 70 is the sigma factor with a molecular weight of 70 kDa . (wikipedia.org)
  • RNA polymerase holoenzyme complex consisting of core RNA polymerase and a sigma factor executes transcription of a DNA template strand. (wikipedia.org)
  • Different sigma factors are utilized under different environmental conditions. (wikipedia.org)
  • [1] In the case of E. coli and other gram-negative rod-shaped bacteria, the "housekeeping" sigma factor is σ 70 . (wikipedia.org)
  • σ 32 (RpoH) - the heat shock sigma factor, it is turned on when the bacteria are exposed to heat. (wikipedia.org)
  • There are also anti-sigma factors that inhibit the function of sigma factors and anti-anti-sigma factors that restore sigma factor function. (wikipedia.org)
Osteoblasts1
  • To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain (DeltaCbfa1) in differentiated osteoblasts only postnatally. (tmc.edu)
Sequence-specific1
  • Integration host factor (IHF) ( IPR005684 , IPR005685 ) is a small heterodimeric protein that binds the minor groove of DNA in a sequence-specific manner and induces a large bend. (ebi.ac.uk)
CBFA11
  • Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. (jax.org)
PMID2
  • It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [ PMID: 10716934 ]. (ebi.ac.uk)
  • The DNA-binding domain of the TraM protein ( IPR007925 ), an essential component of the DNA transfer machinery of the conjugative resistance plasmid R1, appears to have a similar structure to DBPII [ PMID: 11258958 ]. (ebi.ac.uk)
Integrin1
  • Lee JO, Rieu P, Arnaout MA, Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). (springer.com)