Core Binding Factors
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor alpha Subunits
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 1 Subunit
Core Binding Factor beta Subunit
Core Binding Factor Alpha 2 Subunit
Core Binding Factor Alpha 3 Subunit
Transcription Factor AP-2
Transcription Factors
Chromosomes, Human, Pair 16
DNA-Binding Proteins
Chromosome Inversion
Leukemia, Myeloid, Acute
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oncogene Proteins, Fusion
Base Sequence
Chromosomes, Human, Pair 21
Protein Binding
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Binding Sites
Osteoblasts
Enhancer Elements, Genetic
Translocation, Genetic
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mutation
Transforming Growth Factor alpha
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Proto-Oncogene Proteins
Amino Acid Sequence
Cell Differentiation
Transcription, Genetic
Leukemia, Myeloid
Pol1 Transcription Initiation Complex Proteins
Alkaline Phosphatase
Antibodies
Antibody Specificity
Antibodies, Neutralizing
Biotin
Proteasome Endopeptidase Complex
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Granulocytes
Phosphofructokinase-1, Type C
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In the humans, 6-phosphofructose-1-kinase isozyme C is found in platelets, brain, heart, kidney, colon and testis. This isozyme C can exist as the homotetramer of C subunits (P subunits), or heterotetramer of C type and L type subunits.
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
Drosophila
Models, Molecular
Drosophila Proteins
Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans. (1/202)
The Caenorhabditis elegans run gene encodes a Runt domain factor. Runx1, Runx2, and Runx3 are the three known mammalian homologs of run. Runx1, which plays an essential role in hematopoiesis, has been identified at the breakpoint of chromosome translocations that are responsible for human leukemia. Runx2 plays an essential role in osteogenesis, and inactivation of one allele of Runx2 is responsible for the human disease cleidocranial dysplasia. To understand the role of run in C. elegans, we used transgenic run::GFP reporter constructs and a double-stranded RNA-mediated interference method. The expression of run was detected as early as the bean stage exclusively in the nuclei of seam hypodermal cells and lasted until the L3 stage. At the larval stage, expression of run was additionally detected in intestinal cells. The regulatory elements responsible for the postembryonic hypodermal seam cells and intestinal cells were separately located within a 7.2-kb-long intron region. This is the first report demonstrating that an intron region is essential for stage-specific and cell type-specific expression of a C. elegans gene. RNA interference analysis targeting the run gene resulted in an early larva-lethal phenotype, with apparent malformation of the hypodermis and intestine. These results suggest that run is involved in the development of a functional hypodermis and gut in C. elegans. The highly conserved role of the Runt domain transcription factor in gut development during evolution from nematodes to mammals is discussed. (+info)The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene. (2/202)
The Dsi1 locus was identified as a common integration site for Moloney murine leukemia virus (MLV) in rat thymic lymphomas, but previous efforts to identify a gene affected by these insertions were unsuccessful. We considered the Runx3 gene a potential candidate on the basis of genetic mapping which showed that Dsi1 and Runx3 are closely linked on mouse chromosome 4 and the precedent of the related Runx2 gene, which emerged recently as a Myc-collaborating gene activated by retroviral insertion in thymic lymphomas of CD2-MYC mice. We now report the physical mapping of the Dsi1 locus to a site 30 kb upstream of the distal (P1) promoter of the murine Runx3 gene. Comparison with the syntenic region of human chromosome 1 shows that the next gene is over 250 kb 5' to Runx3, suggesting that Runx3 may be the primary target of retroviral insertions at Dsi1. Screening of CD2-MYC lymphomas for rearrangements at Dsi1 revealed a tumor cell line harboring an MLV provirus at this locus, in the orientation opposite that of Runx3. Proviral insertion was associated with very high levels of expression of Runx3, with a preponderance of transcripts arising at the P1 promoter. These results confirm that Runx3 is a target of retroviral insertions at Dsi1 and indicate that Runx3 can act as an alternative to Runx2 as a Myc-collaborating gene in thymic lymphoma. (+info)Causal relationship between the loss of RUNX3 expression and gastric cancer. (3/202)
Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory and apoptosis-inducing action of TGF-beta, indicating that Runx3 is a major growth regulator of gastric epithelial cells. Between 45% and 60% of human gastric cancer cells do not significantly express RUNX3 due to hemizygous deletion and hypermethylation of the RUNX3 promoter region. Tumorigenicity of human gastric cancer cell lines in nude mice was inversely related to their level of RUNX3 expression, and a mutation (R122C) occurring within the conserved Runt domain abolished the tumor-suppressive effect of RUNX3, suggesting that a lack of RUNX3 function is causally related to the genesis and progression of human gastric cancer. (+info)Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype. (4/202)
To identify cell proteins regulated by the Epstein-Barr virus (EBV) transcription factor EBNA-2, we analyzed a cell line with conditional EBNA-2 activity by using microarray expression profiling. This led to the identification of two novel target genes induced by EBNA-2. The first of these, interleukin-16, is an immunomodulatory cytokine involved in the regulation of CD4 T cells. The second, AML-2, is a member of the Runt domain family of transcription factors. Quiescent B cells initially expressed AML-1 but, 48 h after virus infection, the levels of AML-1 decreased dramatically, whereas the amount of AML-2 protein increased. Analysis of a panel of B-cell lines indicated that AML-2 expression is normally predominant in EBV latency III, whereas AML-1 is associated with EBV latency I or EBV-negative cells. The AML genes are the first example of cell transcription factors whose expression correlates with the latency I/III phenotype. (+info)RUNX: a trilogy of cancer genes. (5/202)
The RUNX family of transcription factors plays pivotal roles during normal development and in neoplasias. Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis. (+info)The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. (6/202)
The RUNX transcription factors are important regulators of linage-specific gene expression in major developmental pathways. Recently, we demonstrated that Runx3 is highly expressed in developing cranial and dorsal root ganglia (DRGs). Here we report that within the DRGs, Runx3 is specifically expressed in a subset of neurons, the tyrosine kinase receptor C (TrkC) proprioceptive neurons. We show that Runx3-deficient mice develop severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneurons. We demonstrate that the underlying cause of the defect is a loss of DRG proprioceptive neurons, reflected by a decreased number of TrkC-, parvalbumin- and beta-galactosidase-positive cells. Thus, Runx3 is a neurogenic TrkC neuron-specific transcription factor. In its absence, TrkC neurons in the DRG do not survive long enough to extend their axons toward target cells, resulting in lack of connectivity and ataxia. The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans. (+info)Pathways in blood and vessel development revealed through zebrafish genetics. (7/202)
Studies in zebrafish have potential to contribute to understanding of the vertebrate hematopoietic and vasculogenic systems. Our research has examined the roles of several molecules in pathways that lead to the development of blood and vessels in zebrafish, and has provided insights into the regulation of these processes. Gdf6a/radar, a member of the bone morphogenetic protein (BMP) family, is expressed in the zebrafish hypochord and primitive gut endoderm; structures that flank the developing dorsal aorta and posterior cardinal vein. This pattern of expression positions Gdf6a/radar as a candidate regulator of vasculogenesis. Support for such a role has come from experiments where Gdf6a/radar function was depleted with antisense morpholino oligonucleotides. This resulted in vascular leakiness, suggesting that Gdf6a/radar is involved in maintenance of vascular integrity. The transcription factor Runx1 is known to play a critical role in mammalian definitive hematopoiesis. When Runx1 expression domains and function were analyzed in zebrafish, the importance of this gene in definitive hematopoiesis was confirmed. However there was also evidence for a wider role, including involvement in vascular development and neuropoiesis. This work has laid the foundation for an ethylnitrosourea (ENU) mutagenesis screen based on runx1 whole-mount in situ hybridzation, that aims to identify genes operative in the runx1 pathway. An additional member of the Runx family, Runx3, is also involved in developmental hematopoiesis, with a function distinct from that of Runx1. We hypothesize that Runx1 and Runx3 form a continuum of transcriptional control within the hematopoietic system. An added attraction of zebrafish is that models of human disease can be generated, and we have shown that this system has potential for the study of Runx1-mediated leukemogenesis. (+info)Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. (8/202)
We reported recently that the silencing of RUNX3 is causally related to gastric cancer in humans. Here we report that in three of four cell lines derived from N-methyl-N-nitrosourea-induced mouse glandular stomach carcinomas, Runx3 is silenced due to hypermethylation of CpG islands in the promoter region, as we also observed for human gastric cancer cells. Although two of the sites we tested in the promoter of the fourth line were not methylated, in all four cases the silencing of Runx3 could be reversed by treatment of the cells with 5'-azacytidine and trichostatin A. Interestingly, the exogenous expression of RUNX3 in cell lines that do not express the endogenous gene caused an inhibition of growth in soft agar, suggesting that anchorage-independent growth could be used as an assay of RUNX3 activity in vitro. These observations suggest that the mouse system described here may be useful as a model for the study of human gastric carcinogenesis. (+info)
JCI -
Genetic regulation of the RUNX transcription factor family has antitumor effects
The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells | Haematologica
서울대학교의과대학
Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer<...
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...
Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048
Runx-dependent expression of PKC is critical for cell survival in the by Carrie Dickey-Sims, Anthony J. Robertson et al.
University of Birmingham research gateway
Transcriptional regulation in helper versus cytotoxic-lineage decision. - Semantic Scholar
Gastrokine 1 regulates NF-κB signaling pathway and cytokine expression in gastric cancers<...
JCI -
Genetic regulation of the RUNX transcription factor family has antitumor effects
RUNX proteins in transcription factor networks that regulate T-cell lineage choice
O-GlcNAc Modification of the runt-Related Transcription Factor 2 (Runx2) Links Osteogenesis and Nutrient Metabolism in Bone...
WikiGenes - RUNX1 - runt-related transcription factor 1
RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. - PubMed -...
RUNX Proteins in Development and Cancer Buch versandkostenfrei bei Weltbild.de bestellen
Publications - Mayo Clinic
Runx1 gene cDNA ORF clone, Rattus norvegicus(Norway rat) - GenScript
anti-RUNX1 antibody | GeneTex
anti-RUNX1 antibody | GeneTex
IRESite Id:57 summary record describing characteristics of AML1/RUNX1 IRES
Expression Pattern, Regulation, and Biological Role of Runt Domain Transcription Factor, run, in Caenorhabditis elegans |...
Modulation of Runx proteins by steroid hormone receptors :: University of Southern California Dissertations and Theses
Salivary Gland Development - Embryology
Truncated forms of RUNX3 unlike full length protein alter cell proliferation in a TGF-β context dependent manner
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17...
Xp3 (panel A), GZMB (panel B), RUNX3 (panel C) immunostaining. *P | FGFR/VEGFR inhibitor-vegfrinhibitor.com
The tissue-specific nuclear matrix protein, NMP-2, is a member of the by Harold L. Merriman, Andre J. Van Wijnen et al.
Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or...
Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo | Garvan...
Funny Gene Names - Not To Be Trusted With Knives
HAENLIN/WALTZER - STEM CELLS IN VIVO (a French network)
Loss of RUNX1/ETO Triggers C/EBPα-Driven Reorganizatio | Open-i
Runx Expression in Normal and Osteoarthritic Cartilage: Possible Funct by Kimberly T. LeBlanc
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis...
A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells [PeerJ]
Updates on the hematologic tumor microenvironment and its therapeutic targeting
| Haematologica
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions<...
Recombinant Human RUNX2 protein (ab112259) | Abcam
New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1 | Annals of the Rheumatic Diseases
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation - ePrints -...
Most recent papers with the keyword Vdr | Read by QxMD
JCI -
Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis
core binding factor alpha
Summary Report | CureHunter
RUNX3 expression in primary and metastatic pancreatic cancer | Journal of Clinical Pathology
Col10a1 promoter activity is up-regulated via RUNX2 bin | Open-i
Leukemia - Acute - AML with t(8;21)(q22;q22) RUNX1-RUNX1T1
Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways |...
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function | EMBO...
Browse our RUNX1T1 ELISA Kits
Gentaur Molecular :Zyagen \ RUNX1 Antibody \ APO-000861-M01
CBFA2T3
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...
CBFA2T2
"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the ... doi:10.1016/S0378-1119(99)00481-3. PMID 10675041. Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati ...
Runt domain
... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ... In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has ...
RNA polymerase
... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa):[23] *β': The β' subunit is the largest subunit, and is encoded by the rpoC gene.[ ... In order to bind promoters, RNAP core associates with the transcription initiation factor sigma (σ) to form RNA polymerase ...
TAF11
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 ... The conserved region contains four alpha helices and three loops arranged as in histone H3. TAF11 has been shown to interact ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ...
Sigma factor
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... later showed that the sigma factor does not obligatorily leave the core. Instead, it changes its binding with the core during ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Therefore, the sigma factor, cycles between a strongly bound state during initiation and a weakly bound state during elongation ...
RUNX1
... or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. RUNX1 is a ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...
CBFB
... it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and ... Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...
TBP-associated factor
Selective factor 1 is composed of the TATA-binding protein and three TAF (TATA box-binding protein-associated factor) subunits ... It contains two short alpha helices and a long central alpha helix. TAF1 (TAFII250) TAF2 (CIF150) TAF3 (TAFII140) TAF4 ( ... for example the downstream promoter element or gene-specific core promoter sequence Due to such interactions, they contribute ... The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a ...
CAAT box
These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... The first domain (A1) contains 20 amino acids that forms an alpha helix that appears significant in its interactions with NF-YB ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...
GTF2A1L
This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...
Promoter (genetics)
DNA binding by the alpha subunit of RNA polymerase". Science. 262 (5138): 1407-1413. Bibcode:1993Sci...262.1407R. doi:10.1126/ ... "New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An example is the E-box (sequence CACGTG), which binds transcription factors in the basic helix-loop-helix (bHLH) family (e.g. ...
SEC61B
This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...
Promoter (genetics)
DNA binding by the alpha subunit of RNA polymerase". Science. 262 (5138): 1407-13. Bibcode:1993Sci...262.1407R. doi:10.1126/ ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ...
Sigma factor
The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) subunits) binds a sigma ... Sigma factors in E. coli:. *σ70(RpoD) - σA - the "housekeeping" sigma factor or also called as primary sigma factor, ... Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...
Sec61 alpha 1
Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...
TAF9
This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several ... The protein complex that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to ... "Induced alpha helix in the VP16 activation domain upon binding to a human TAF". Science. 277 (5330): 1310-3. doi:10.1126/ ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ...
EGLN1
In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... "Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases". Structure. 17 (7): 981-9. ... The catalytic domain consists of a double-stranded β-helix core that is stabilized by three α-helices packed along the major β- ... X-ray crystallography and NMR spectroscopy showed that both peptides bind to the same binding site on PHD2, in a cleft on the ...
TAF15
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a ... This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and ... TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription ...
RUNX2
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. The Runx2 DNA-binding activity is correlated with ...
CREB-binding protein
"BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit". The ... Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T (April 2002). "Prothymosin alpha interacts with the CREB-binding ... hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ...
PSMD10
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
ATP-binding cassette transporter
... sandwiched between the Walker A and B motifs of one subunit and the LSGGQ motif of the other subunit. The maltose binding ... heme-binding protein, and alkaline protease), heme, hydrolytic enzymes, S-layer proteins, competence factors, toxins, ... In addition, a gap in the protein is accessible directly from the hydrophobic core of the inner leaflet of the membrane bilayer ... The T domains are each built of typically 10 membrane spanning alpha helices, through which the transported substance can cross ...
POLR2J
"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599-606. doi:10.1006/jmbi. ... "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655-66. ... The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of ...
EIF-W2 protein domain
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... The W2 domain has a globular fold and is exclusively composed out of alpha-helices. ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ...
CUL4A
The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ...
PSMC5
"The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative ... which interacts with the seven-membered alpha ring of 20S core particle and eastablishs an asymmetric interface between the 19S ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
Ars operon
It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...
General transcription factor
The core enzyme of RNA polymerase has five subunits (protein subunits) (~400 kDa). Because of the RNA polymerase association ... with sigma factor, the complete RNA polymerase therefore has 6 subunits: the sigma subunit-in addition to the two alpha (α), ... binds to TATA box binding protein (TBP) and recognizes TATA boxTBP associated factors (TAFs) and add promoter selectivity TFIIE ... The RNA polymerase core associates with the sigma factor to form RNA polymerase holoenzyme. Sigma factor reduces the affinity ...
LSm
Törö I, Thore S, Mayer C, Basquin J, Séraphin B, Suck D (May 2001). "RNA binding in an Sm core domain: X-ray structure and ... RNA oligonucleotides generally bind inside the hole (lumen) of the LSm torus, one nucleotide per LSm subunit, but additional ... The short (two to four turns) N-terminal alpha helix occurs at one edge of the beta sandwich. This alpha helix and the beta ... the Sm-like protein HF-I encoded by the gene hfq was described in 1968 as an essential host factor for RNA bacteriophage Qβ ...
Alkali metal
... caused by the alpha decay of actinium-227.[35] Perey then attempted to determine the proportion of beta decay to alpha decay in ... Gottschlich, Michele M. (2001). The Science and Practice of Nutrition Support: A Case-based Core Curriculum. Kendall Hunt. p. ... The first factor depends on the volume of the atom and thus the atomic radius, which increases going down the group; thus, the ... Solid phenyllithium forms monoclinic crystals can be described as consisting of dimeric Li2(C6H5)2 subunits. The lithium atoms ...
Receptor (biochemistry)
They are composed of a C-terminal ligand-binding region, a core DNA-binding domain (DBD) and an N-terminal domain that contains ... They have a heteromeric structure in that each subunit consists of the extracellular ligand-binding domain and a transmembrane ... The loops connecting the alpha helices form extracellular and intracellular domains. The binding-site for larger peptide ... The N terminus interacts with other cellular transcription factors in a ligand-independent manner; and, depending on these ...
NPM1 - Wikipédia, a enciclopédia livre
protein kinase binding. • core promoter binding. • RNA polymerase II transcription coactivator activity. • transcription factor ... ribosomal large subunit binding. • protein homodimerization activity. • ribosomal small subunit binding. • unfolded protein ... regulation of eIF2 alpha phosphorylation by dsRNA. • positive regulation of cell cycle G2/M phase transition. • negative ... activating transcription factor binding. • rRNA binding. • protein N-terminus binding. • chromatin binding. ...
Brain-derived neurotrophic factor
BDNF is made in the endoplasmic reticulum and secreted from dense-core vesicles. It binds carboxypeptidase E (CPE), and the ... "Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord". ... "Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole ... receptor binding. • neurotrophin TRKB receptor binding. • growth factor activity. • GO:0001948 protein binding. ...
Proteasome
... a 9-subunit base that binds directly to the α ring of the 20S core particle, and a 10-subunit lid. Six of the nine base ... Degradation of Aux/IAA proteins derepresses transcription factors in the auxin-response factor (ARF) family and induces ARF- ... which serve as docking domains for the regulatory particles and the alpha subunits N-termini (Pfam PF10584) form a gate that ... The mechanisms by which it binds to the core particle through the C-terminal tails of its subunits and induces α-ring ...
Aminoacyl tRNA synthetase
The alpha helical anticodon binding domain of Arginyl, Glycyl and Cysteinyl-tRNA synthetases is known as the DALR domain after ... Alignment of the core domains of aminoacyl-tRNA synthetases class I and class II. Essential binding site residues (Backbone ... two or four subunits, respectively). Although phenylalanine-tRNA synthetase is class II, it aminoacylates at the 2'-OH. ... and an anticodon binding domain (which interacts mostly with the anticodon region of the tRNA and ensures binding of the ...
Protein
... s can bind to other proteins as well as to small-molecule substrates. When proteins bind specifically to other copies of ... Kauzmann W (May 1956). "Structural factors in protein denaturation". Journal of Cellular Physiology. 47 (Suppl 1): 113-31. doi: ... Quaternary structure: the structure formed by several protein molecules (polypeptide chains), usually called protein subunits ... The membrane alone has a hydrophobic core through which polar or charged molecules cannot diffuse. Membrane proteins contain ...
Francis Crick
... the alpha helix). Linus Pauling was the first to identify[29] the 3.6 amino acids per helix turn ratio of the alpha helix. ... It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... In 1960, Crick accepted an honorary fellowship at Churchill College, Cambridge, one factor being that the new college did not ...
Cellulase
... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity.[12] ... McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-beta-D-glucanase". ... construction of the catalytic core, expression, and X-ray structure at 1.75 Å resolution". Biochemistry. 36 (51): 16032-9. doi: ...
Myofilament
Each tropomyosin molecule has a smaller calcium-binding protein called troponin bound to it. All thin filaments are attached to ... The filaments are organized into repeated subunits along the length of the myofibril. These subunits are called sarcomeres. ... They run through the core of each thick filament and anchor it to the Z-line, the end point of a sarcomere. Titin also ... Troponin and the associated tropomyosin undergo a conformational change after calcium binding and expose the myosin binding ...
AMPA receptor
Each AMPAR has four sites to which an agonist (such as glutamate) can bind, one for each subunit.[5] The binding site is ... Armstrong N, Sun Y, Chen GQ, Gouaux E (October 1998). "Structure of a glutamate-receptor ligand-binding core in complex with ... "Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP ... Mammen AL, Kameyama K, Roche KW, Huganir RL (December 1997). "Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4- ...
C1QBP
This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding ... C1QBP has been shown to interact with Protein kinase D1,[10] BAT2,[11] PRKCD,[10] PKC alpha[10] and Protein kinase Mζ.[10] ... "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation". J Clin ... transcription factor binding. • protein binding. • hyaluronic acid binding. • kininogen binding. • mitochondrial ribosome ...
Tyrosine hydroxylase
Each subunit consists of three domains. At the carboxyl terminal of the peptide chain there's a short alpha helix domain that ... oxygen binding. • metal ion binding. • dopamine binding. • enzyme binding. • oxidoreductase activity. • iron ion binding. • ... response to growth factor. • response to ethanol. • cellular response to glucose stimulus. • phthalate metabolic process. • ... allows tetramerization.[15] The central ~300 amino acids make up a catalytic core, in which all the residues necessary for ...
dnaQ
... is the gene encoding the ε subunit of DNA polymerase III in Escherichia coli.[1] The ε subunit is one of three core ... of the gene product binds the θ subunit and carries out the exonuclease function and the C-terminus binds the α subunit ... "The proofreading exonuclease subunit epsilon of Escherichia coli DNA polymerase III is tethered to the polymerase subunit alpha ... The ε subunit is stabilized by the θ subunit within the complete polymerase complex.[7] ...
FOXA2
transcription factor activity, sequence-specific DNA binding. • transcription factor binding. • RNA polymerase II core promoter ... 2009). "The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of ... "Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression". J. Mol. ... transcription regulatory region DNA binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ...
Iron
14 alpha particles) is easily produced from lighter nuclei in the alpha process in nuclear reactions in supernovae (see silicon ... The inner core of the Earth is generally presumed to consist of an iron-nickel alloy with ε (or β) structure.[10] ... Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... The ensuing availability of inexpensive iron was one of the factors leading to the Industrial Revolution. Toward the end of the ...
Drosophila melanogaster
InaD contains five binding domains called PDZ domain proteins, which specifically bind the C termini of target proteins. ... Drosophila differentially expresses a core group of 252 genes upon infection with most bacteria. This core group of genes is ... Bakker K (1961). "An analysis of factors which determine success in competition for food among larvae of Drosophila ... A 2016 study concluded that food supplementation with 10-mM alpha-ketoglutarate decreased Drosophila alcohol sensitivity over ...
Protein kinase A
The activated Gs alpha subunit binds to and activates an enzyme called adenylyl cyclase, which, in turn, catalyzes the ... crystallised the PKA Cα subunit, which revealed the bi-lobe structure of the protein kinase core for the very first time, ... Long term memory is dependent on the CREB transcription factor, regulated by PKA. A study done on drosophila reported that an ... Two cAMP molecules bind to each PKA regulatory subunit. *The regulatory subunits move out of the active sites of the catalytic ...
DNA methyltransferase
In the presence of the R subunit, the complex can also act as an endonuclease, binding to the same target sequence but cutting ... A conserved enzyme core with variable target-recognizing domains". J. Mol. Biol. 206 (2): 305-12. doi:10.1016/0022-2836(89) ... hsdM contains an alpha-helical domain at the N-terminus, the HsdM N-terminal domain.[7] ... The type I restriction and modification system is composed of three polypeptides R, M and S. The M (hsdM) and S subunits ...
Protein metabolism
For example, a protein called eukaryotic initiation factor-2 (eIF-2) can bind to the smaller subunit of the ribosome, starting ... The two reacting molecules are the alpha amino group of one amino acid and the alpha carboxyl group of the other amino acids. A ... In a hydrophilic environment such as cytosol, the hydrophobic amino acids will concentrate at the core of the protein, while ... These subunits surround the mRNA strand. The larger subunit contains three binding sites: A (aminoacyl), P (peptidyl), and E ( ...
Retinoblastoma protein
ubiquitin protein ligase binding. • importin-alpha family protein binding. • disordered domain specific binding. • core ... DNA binding. • core promoter binding. • transcription factor activity, sequence-specific DNA binding. • transcription ... Within each subunit, there are a variety of protein binding sites, as well as a total of 15 possible phosphorylation sites. ... transcription factor binding. • RNA polymerase II activating transcription factor binding. • phosphoprotein binding. • kinase ...
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
An important factor in the binding of the first generation NNRTIs, such as nevirapine, is the butterfly-like shape. Despite ... The cloroindole part interacted with the hydrophobic core of the pocket and influenced the binding mode of the R120393 so it ... Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU)". Bioorganic & Medicinal Chemistry Letters. 11 ... Å from the catalytic site in the palm domain of the p66 subunit site of the enzyme. The NNRTI binding pocket (NNIBP) contains ...
Lipid
Most vegetable oils are rich in linoleic acid (safflower, sunflower, and corn oils). Alpha-linolenic acid is found in the green ... Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227-30 ... The steroids, all derived from the same fused four-ring core structure, have different biological roles as hormones and ... Polyketides are synthesized by polymerization of acetyl and propionyl subunits by classic enzymes as well as iterative and ...
Virus
The same protein may act as the subunit of both the pentamers and hexamers or they may be composed of different proteins.[81]. ... When the adaptive immune system of a vertebrate encounters a virus, it produces specific antibodies that bind to the virus and ... Counting these areas and multiplying by the dilution factor allowed him to calculate the number of viruses in the original ... Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: The ...
HMGA1
0001204 DNA-binding transcription factor activity. • 5'-deoxyribose-5-phosphate lyase activity. • transcription factor binding ... "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y ... core motif, a novel cross-linking domain located between the second and third AT-hook, and a C-terminal acidic tail ... "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions ...
Respiratory complex I
Assembly factor proteins[31] 47. NDUFAF1c. CIA30_HUMAN. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 1. ... Core Subunitsa 1. NDUFS7 / PSST / NUKM. NDUS7_HUMAN. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial EC ... Complex I contains a ubiquinone binding pocket at the interface of the 49-kDa and PSST subunits. Close to iron-sulfur cluster ... 1 alpha subcomplex subunit 7. Pfam PF07347 38. NDUFA3 / B9. NDUA3_HUMAN. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex ...
Alpha helix
Zipper Coiled-Coil Domains of the cGMP-Dependent Protein Kinase I alpha and its Interaction with the Myosin Binding Subunit of ... Leucine zipper coiled-coil helices & DNA-binding helices: transcription factor Max (PDB file 1HLO) ... in the hydrophobic core, and one containing predominantly polar amino acids oriented toward the solvent-exposed surface of the ... DNA bindingEdit. α-Helices have particular significance in DNA binding motifs, including helix-turn-helix motifs, leucine ...
Aminoglycoside
X-ray crystallographic structure of the 30S ribosomal subunit with bound drug (purple, space-filling model, at center) protein ... Volume 1. Core Clinical Skills. Oxford University Press. 2010. *^ referenced in Treatment of Mitochodrial Disease: Bindu LH, ... PubMed:19031229] See Also Fischel-Ghodsian N. Genetic factors in aminoglycoside toxicity. Ann NY Acad Sci. 1999; 884:99-109. [ ... secondary structure elements such as alpha-helices in bright green, and the RNA phosphodiester backbone shown in orange (and ...
Core-binding factor, runt domain, alpha subunit 3 | definition of core-binding factor, runt domain, alpha subunit 3 by Medical...
What is core-binding factor, runt domain, alpha subunit 3? Meaning of core-binding factor, runt domain, alpha subunit 3 medical ... What does core-binding factor, runt domain, alpha subunit 3 mean? ... core-binding factor, runt domain, alpha subunit 3 explanation ... Looking for online definition of core-binding factor, runt domain, alpha subunit 3 in the Medical Dictionary? ... redirected from core-binding factor, runt domain, alpha subunit 3) RUNX3. A gene on chromosome 1p36 that encodes a member of ...
Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), transcript...
... alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), transcript variant 2, (10ug), 10 µg. ... Home » cDNA » Mouse cDNA » Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 ( ... MC219266 Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3), ... Properties for Cbfa2t3 (untagged) - Mouse core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) ( ...
Runx3 - Runt-related transcription factor 3 - Mus musculus (Mouse) - Runx3 gene & protein
... while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of ... The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus ... CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding ... RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5-TGTGGT ...
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
Core Binding Factor Alpha 1 Subunit * Core Binding Factor Alpha 2 Subunit ... Core Binding Factor Alpha 1 Subunit * Core Binding Factor Alpha 2 Subunit ... organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear ... Core Binding Factor alpha Subunits * DNA-Binding Proteins / genetics * DNA-Binding Proteins / metabolism ...
Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample
REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies
Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (Predicted). ... PREDICTED: transcription initiation factor TFIID subunit 4-like[Cricetulus griseus].. 11. Mus musculus. 12396. Cbfa2t2; ... PREDICTED: transcription initiation factor TFIID subunit 4B-like[Cricetulus griseus].. 10. Cricetulus griseus. 100769929. ... PREDICTED: transcription initiation factor TFIID subunit 4-likeisoform 1 [Bombus impatiens].. 31. Pteropus vampyrus. ...
Arumugam Balasubramanian, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Core Binding Factor Alpha 1 Subunit. Enzyme Induction. Okadaic Acid. Bone Remodeling. Mesenchymal Stem Cells. Osteoblasts. ... Transforming Growth Factor beta1. Down-Regulation. Up-Regulation. 3 Untranslated Regions. Activating Transcription Factor 3. ... Core Binding Factor Alpha 1 Subunit. 3. 2015. 2018. March 2017. Enzyme Induction. 1. 2017. 2017. May 2017. ... Core Binding Factor Alpha 1 Subunit * Matrix Metalloproteinase 13 * Transforming Growth Factor beta1 ...
CBFA2/RUNX1 translocation partner 2 ELISA Kits | Biocompare.com
RUNX3/CBFA3 Antibody (2B10E8) [DyLight 488] (NBP2-22391G): Novus Biologicals
RUNX3/CBFA3 Antibody (2B10E8) [Biotin] (NBP2-22391B): Novus Biologicals
CBFA2T3 - Wikipedia
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...
Calcium Amino Acid Chelate (Bottle Package)
2. Fast two directional hand movements 3. Recommended for drawing curved hair stro ... Adenovirus with ORF of core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3), transcript variant 2 ... Adenovirus with ORF of core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2), transcript variant 4 ... Adenovirus with ORF of core-binding factor, beta subunit (CBFB), transcript variant 2 with C terminal Flag and His tag. ...
CBFA2T3 - PrimePCR Assay and Template | Life Science | Bio-Rad
Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Assay Type: Probe Assay Design: Exonic Application: Gene ... Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Assay Type: SYBR® Green Assay Design: Exonic Application ... Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting ...
CBFA2T2 - Wikipedia
"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the ... doi:10.1016/S0378-1119(99)00481-3. PMID 10675041. Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati ...
CBFA2T3 - Protein CBFA2T3 - Homo sapiens (Human) - CBFA2T3 gene & protein
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription ... factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the ... cDNA FLJ33666 fis, clone BRAMY2027752, highly similar to Homo sapiens core-binding factor, runt domain, alpha subunit 2; ... cDNA FLJ33666 fis, clone BRAMY2027752, highly similar to Homo sapiens core-binding factor, runt domain, alpha subunit 2; ...
CBFA2T3 (Human) Recombinant Protein (P01) - (H00000863-P01) - Products - Abnova
core-binding factor, runt domain, alpha subunit 2; translocated to, 3. *Omim ID: ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ... The translocation produces a chimeric gene made up of the 5-region of the AML1 gene fused to the 3-region of this gene. In ...
Sequence Detail
Core-binding factor subunit alpha-1; Short=CBF-alpha-1;AltName: Full=Oncogene AML-3;AltName: Full=Osteoblast-specific ... the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993 May;194(1):314-31 ... J:19082 Ogawa E, et al., PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila ... J:49076 Xiao ZS, et al., Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. ...
Cbfa2t3 - PrimePCR Assay and Template | Life Science | Bio-Rad
Core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) Assay Type: SYBR® Green Assay Design: exonic ... Core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) Assay Type: Probe Assay Design: exonic ... Core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) Assay Type: Probe Application: Gene Expression ... Core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) Assay Type: Probe Application: Gene Expression ...
Protein-Protein Interaction - TFCatWiki
calmodulin binding transcription activator 2. Cbfa2t3 12398. core-binding factor, runt domain, alpha subunit 2, translocated to ... cop9 (constitutive photomorphogenic) homolog, subunit 2 (arabidopsis thaliana). Creb3 12913. camp responsive element binding ... dead/h (asp-glu-ala-asp/his) box polypeptide 3, x-linked. ... c-terminal binding protein 1. Ctbp2 13017. c-terminal binding ...
Downregulation of RUNX3 and TES by hypermethylation in glioblastoma - University of Regensburg Publication Server
CBFA2T3 Antibody 17190-1-AP | Proteintech
RUNX1 Antibody (710233)
CBF-alpha-2; core binding factor alpha 2; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit ... SL3/AKV core-binding factor alpha B subunit; transcription factor Gene Aliases: AML1; AML1-EVI-1; AMLCR1; CBF-alpha-2; ... Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; Runt-related transcription factor ... DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding transcription factor binding ...
Recombinant Human RUNX2 protein (ab112259) | Abcam
SL3/AKV core binding factor alpha A subunit. *SL3/AKV core-binding factor alpha A subunit ... Core binding factor. *Core binding factor runt domain alpha subunit 1. *Core binding factor subunit alpha 1 ... CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ... Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of ...
Anti-RUNX2 antibody (ab76956) | Abcam
SL3/AKV core binding factor alpha A subunit antibody. *SL3/AKV core-binding factor alpha A subunit antibody ... Polyomavirus enhancer binding protein 2 alpha A subunit antibody. *Polyomavirus enhancer-binding protein 2 alpha A subunit ... Core binding factor runt domain alpha subunit 1 antibody. *Core binding factor subunit alpha 1 antibody ... CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, ...
RUNX2 gene: MedlinePlus Genetics
SL3/AKV core-binding factor alpha A subunit. Additional Information & Resources. Tests Listed in the Genetic Testing Registry. ... The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the ... 2006 Jan 3 [updated 2017 Nov 16]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A, editors. ... 2017 Mar;60(3):163-168. doi: 10.1016/j.ejmg.2016.12.007. Epub 2016 Dec 24. Citation on PubMed ...
ZFIN Publication: Li et al., 2015
Core Binding Factor Alpha 2 Subunit/metabolism; Female; Gene Expression Regulation; Hematopoiesis*; Hematopoietic Stem Cell ... Transcription Factor AP-1/metabolism; Transcription, Genetic; Zebrafish/embryology* ... This effect required the activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway, specifically PI(3)Kγ. In adult ...
ZFIN Publication: Kalev-Zylinska et al., 2002
Core Binding Factor Alpha 2 Subunit; DNA, Complementary; DNA-Binding Proteins/classification; DNA-Binding Proteins/genetics; ... Transcription Factors/classification; Transcription Factors/genetics; Transcription Factors/physiology*; Transgenes; Zebrafish/ ... runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl, and expression of ... DNA-Binding Proteins/physiology*; Disease Models, Animal; Gene Expression; Hematopoiesis/physiology*; Hematopoietic Stem Cells/ ...
Molecular Vision: Effect of PITX2 knockdown on transcriptome
of primary human trabecular meshwork cell cultures
... sterile alpha motif domain containing 5), CBFB (core-binding factor, beta subunit), and MEIS2 (meis homeobox 2). Real time PCR ... The five genes identified by all the protocols were DIRAS3, CXCL6, SAMD5, CBFB (core-binding factor, beta subunit), and MEIS2. ... latent transforming growth factor beta binding protein 2), a primary glaucoma causing gene, was not probed on the arrays [42]. ... Loss of function mutations in the gene encoding latent transforming growth factor beta binding protein 2, LTBP2, cause primary ...
core binding factor alpha
Summary Report | CureHunter
... core binding factor plays a key role in several development pathways and in human disease; has been sequenced ... Transcription Factors: 20597*Core Binding Factors: 223*Core Binding Factor alpha Subunits: 18*core binding factor alpha: 16 ... core binding factor alpha. Subscribe to New Research on core binding factor alpha ... 11/07/2000 - "Binding of CBFalpha/AML/PEBP2alpha (core binding factor alpha/acute myelogenous leukemia/polyoma enhancer binding ...
"Runx2 mediates epigenetic silencing of the bone morphogenetic protein-" by Manish Tandon, Karthiga Devi Gokul et al.
The transforming growth factor beta (TGF-beta) family member bone morphogenetic protein-3B (BMP-3B/GDF10) is regarded as a ... The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells ... The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several ... Core Binding Factor Alpha 1 Subunit; Bone Morphogenetic Protein 3; Lung Neoplasms ...
RUNX3ProteinsRunx2CBFBAML1HumansRegulatoryPromoterRUNX1GenesAllosterically enhancesBetaHoloenzymeRegulationRUNXInitiation factorFamily of transcription factorsTranscriptionalComplexPolymerasesPolyomavirusApoptosisChromosomeAssaysPolypeptideEukaryotesPMIDDifferentiationBacterialFibroblastZincPolymerase II corePhosphatidylinositolOmegaAntibody
RUNX325
- A heterodimer of RUNX3 and a beta subunit form a complex found in a number of enhancers and promoters, and together either activate or suppress transcription. (thefreedictionary.com)
- RUNX3 is a tumour suppressor which also interacts with other transcription factors. (thefreedictionary.com)
- Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. (nih.gov)
- Circulating human CD4(+) CD25(high) CD127(-) T reg cells significantly expressed higher levels of RUNX3, FOXP3, and TGF-beta mRNA compared with CD4(+)CD25(-) cells.Furthermore, FOXP3 and RUNX3 were colocalized in human tonsil T reg cells.These data demonstrate Runx transcription factors as a molecular link in TGF-beta-induced Foxp3 expression in iT reg cell differentiation and function. (nih.gov)
- In this study, we show that the transforming growth factor-beta (TGF-beta) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4(+) T cells. (nih.gov)
- This induction seems to be a prerequisite for the binding of RUNX1 and RUNX3 to three putative RUNX binding sites in the FOXP3 promoter. (nih.gov)
- Inactivation of the gene encoding RUNX cofactor core-binding factor-beta (CBFbeta) in mice and small interfering RNA (siRNA)-mediated suppression of RUNX1 and RUNX3 in human T cells resulted in reduced expression of Foxp3. (nih.gov)
- Runt-related transcription factor RUNX3 is a target of MDM2-mediated u" by Xin-Zi Chi, Jiyeon Kim et al. (umassmed.edu)
- RUNX3 directly binds MDM2 through its Runt-related DNA-binding domain. (umassmed.edu)
- MDM2 blocks RUNX3 transcriptional activity by interacting with RUNX3 through an acidic domain adjacent to the p53-binding domain of MDM2 and ubiquitinates RUNX3 on key lysine residues to mediate nuclear export and proteasomal degradation. (umassmed.edu)
- A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology. (nih.gov)
- [email protected]#To study the mRNA level of runt-related transcription factor 3 (RUNX3) in children with bronchiolitis and its clinical significance in bronchiolitis. (bvsalud.org)
- PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). (bvsalud.org)
- The aim of this study was to examine the correlation between clinicopathologic factors and RUNX3 hypermethylation/expression in CRC. (bvsalud.org)
- However, expression of RUNX3 was not a prognostic factor (P = 0.363). (bvsalud.org)
- BACKGROUND/AIMS: Helicobacter pylori cytotoxin-associated gene A (CagA) has been suggested to be involved in the inactivation of Runt-related transcription factor 3 (RUNX3), a known gastric carcinoma tumor suppressor gene. (bvsalud.org)
- Zebrafish embryos lacking Rad21 (show RAD21 ELISA Kits ), or cohesin subunit Smc3 (show SMC3 ELISA Kits ), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 ELISA Kits ) expression in early embryonic development. (antibodies-online.com)
- Mechanistically, the Runx3 - CBFbeta (show CBFB ELISA Kits ) transcription factor complex deployed H3K27me3 to Bcl6 (show BCL6 ELISA Kits ) and Tcf7 (show TCF7 ELISA Kits ) genes to suppress the TFH program. (antibodies-online.com)
- Core binding factors are heterodimeric transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBF beta subunit. (ox.ac.uk)
- METHODS: We performed conditional analysis of genetic association data and used ENCODE data on chromatin remodelling and transcription factor (TF) binding sites to identify the primary AS-associated regulatory SNP in the RUNX3 region. (ox.ac.uk)
- The risk allele decreases TF binding (including IRF4) and reduces reporter activity and RUNX3 expression. (ox.ac.uk)
- The present study aimed to explore the association between runt-related transcription factor 3 (RUNX3) gene polymorphisms in severe preeclampsia (SPE) and clinical features.A total of 417 participants were enrolled in the present study. (cdc.gov)
- PCR-RFLP = polymerase chain reaction-restriction fragment length polymorphism, RUNX3 = human runt-related transcription factor 3. (cdc.gov)
- RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. (duke.edu)
- We hypothesize that SEG-1 cells lack the tumor-suppressor gene Runt domain transcription factor 3 (RUNX3) and that its reinstatement can restore the antiproliferative and apoptotic effects of TGF-beta. (duke.edu)
Proteins21
- We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture. (nih.gov)
- RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. (thermofisher.com)
- Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
- Cytoplasmic calcium acts as a signal by binding to high-affinity calcium-binding proteins. (springer.com)
- An important subset of these intracellular calcium-binding proteins are proteins that also interact with membranes in a calcium-regulated fashion. (springer.com)
- Creutz CE, Tomsig JL, Snyder SL, Skouri F, Beisson J, Cohen J. The copines: a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. (springer.com)
- Copines: a ubiquitous family of Calcium-dependent, phospholipid-binding proteins. (springer.com)
- The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. (ebi.ac.uk)
- This entry represents the conserved amino terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria (TFE) that are also presumed to be TFIIE-alpha subunits [ PMID: 9389475 ]. (ebi.ac.uk)
- Among these AETFC components, HEB and E2A, two members of the ubiquitously expressed E proteins, directly interact with AML1-ETO, confer new DNA-binding capacity to AETFC, and are essential for leukemogenesis. (cancer-genetics.org)
- We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for these proteins in autoimmunity. (ox.ac.uk)
- The proteins that guide RNA polymerase to genes are the sigma factors. (wikibooks.org)
- It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. (nih.gov)
- Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. (nih.gov)
- Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. (antikoerper-online.de)
- At the core, the bHLH-PAS transcriptional activators CLOCK and BMAL1 activate the Period ( Per1, Per2 ) and Cryptochrome ( Cry1, Cry2 ) genes, whose transcripts and proteins slowly accumulate during the daytime. (hhmi.org)
- The structural proteins that are located in the amino-terminal region of the polyprotein are the core protein and the envelope glycoproteins E1 and E2 ( 22 ). (asm.org)
- Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. (wikipedia.org)
- A promoter is induced in response to changes in abundance or conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase. (wikipedia.org)
- RNA binding proteins are fundamental components of crucial biological processes in all domains of life. (dartmouth.edu)
- For wider applicability, top-down mass spectrometry must address the entire proteome including the membrane proteins that constitute 20 to 30% of the open reading frames (ORF's) in fully sequenced genomes [ 3 ], with their important functions ranging from photosynthesis, respiration and cellular communication to small molecule transport. (pubmedcentralcanada.ca)
Runx29
- Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. (jax.org)
- Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway. (jax.org)
- Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. (jax.org)
- The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
- BACKGROUND: The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and promotes invasive properties. (umassmed.edu)
- The ectopic expression of Runx2, but not DNA binding mutant Runx2, in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels. (umassmed.edu)
- MBS934869 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the runt-related transcription factor 2 (RUNX2) ELISA Kit target analytes in biological samples. (mybiosource.com)
- Standards and samples are pipetted into the wells and any RUNX2 present is bound by the immobilized antibody. (mybiosource.com)
- Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of RUNX2 bound in the initial step. (mybiosource.com)
CBFB11
- Forms the heterodimeric complex core-binding factor (CBF) with CBFB. (uniprot.org)
- RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (uniprot.org)
- Adenovirus with ORF of core-binding factor, beta subunit (CBFB), transcript variant 2 with C terminal Flag and His tag. (trademetro.net)
- The five genes were DIRAS3 (DIRAS family, GTP-binding RAS-like 3), CXCL6 (chemokine (C-X-C motif) ligand 6), SAMD5 (sterile alpha motif domain containing 5), CBFB (core-binding factor, beta subunit), and MEIS2 (meis homeobox 2). (molvis.org)
- This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
- RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (acris-antibodies.com)
- Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein. (diagenode.com)
- CBFb (UniProtKB/Swiss-Prot entry Q13951) represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. (diagenode.com)
- CBFB enhances DNA binding by RUNX1. (nih.gov)
- uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. (nih.gov)
- Confirmation of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a time resolved fluorescence resonance energy transfer (TR-FRET) assay. (nih.gov)
AML18
- The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. (wikipedia.org)
- The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. (wikipedia.org)
- PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. (jax.org)
- A common chromosomal translocation in acute myeloid leukemia (AML) involves the AML1 (acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBF alpha), and PEBP2 alpha B) gene on chromosome 21 and the ETO (eight-twenty one, also called MTG8) gene on chromosome 8. (curehunter.com)
- One of the genes that encodes a CBF alpha subunit is AML1, also called Cbf alpha 2. (curehunter.com)
- In leukemic cells, AML1-ETO resides in and functions through a stable protein complex, AML1-ETO-containing transcription factor complex (AETFC), that contains multiple transcription (co)factors. (cancer-genetics.org)
- However, the third E protein, E2-2, is specifically silenced in AML1-ETO-expressing leukemic cells, suggesting E2-2 as a negative factor of leukemogenesis. (cancer-genetics.org)
- Indeed, ectopic expression of E2-2 selectively inhibits the growth of AML1-ETO-expressing leukemic cells, and this inhibition requires the bHLH DNA-binding domain. (cancer-genetics.org)
Humans1
- translocated to, 3) is a protein that in humans is encoded by the CBFA2T3 gene. (wikipedia.org)
Regulatory2
- This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. (abnova.com)
- The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. (diagenode.com)
Promoter20
- Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. (stjohnslabs.com)
- In order to search for potential new therapeutic targets, we relied on computational methods aimed at identifying transcription factor binding sites (TFBSs) over-represented in the promoter regions of genes differentially expressed in PAC. (nih.gov)
- DEMON relies on a hidden Markov model to score the appearance of sequence motifs, taking into account all potential sites in a promoter of potentially varying binding affinities. (nih.gov)
- Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. (ebi.ac.uk)
- TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. (ebi.ac.uk)
- A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a promoter region before RNAP can initiate the DNA unwinding at that position. (wikipedia.org)
- Since RNA polymerase , the enzyme that synthesizes RNA from DNA, polymerizes RNA from the 5' to 3' end, the promoter site where it attaches is always upstream, meaning closer to the 5' end of the DNA, from the gene of interest. (wikibooks.org)
- A sigma factors binds RNA polymerase through the alpha subunit and then helps the core enzyme detect or a recognize a specific DNA sequence, this is called a promoter. (wikibooks.org)
- They also help core RNA polymerase locate the consensus promoter sequences near the beginning of a gene. (wikibooks.org)
- There is no lactose to inhibit the repressor , so the repressor binds to the operator , which obstructs the RNA polymerase from binding to the promoter and making lactase. (wikipedia.org)
- Lactose is inhibiting the repressor, allowing the RNA polymerase to bind with the promoter and express the genes, which synthesize lactase. (wikipedia.org)
- The promoter is recognized by RNA polymerase and an associated sigma factor , which in turn are often brought to the promoter DNA by an activator protein's binding to its own DNA binding site nearby. (wikipedia.org)
- The process is more complicated, and at least seven different factors are necessary for the binding of an RNA polymerase II to the promoter. (wikipedia.org)
- On average, only 3 to 4 of the 6 base pairs in each consensus sequence are found in any given promoter. (wikipedia.org)
- These assays defined specific long‐range interactions between intergenic HIF ‐binding regions and one or more promoters of hypoxia‐inducible genes, revealing the existence of multiple enhancer-promoter, promoter-enhancer, and enhancer-enhancer interactions. (embopress.org)
- These cis ‐interactions pre‐date binding of HIF , supporting a model in which HIF binds to primed enhancer-promoter complexes that enable rapid activation of its transcriptional program through the release of promoter‐proximal paused RNA polymerase 2. (embopress.org)
- Both cell‐specific binding of HIF to these enhancer-promoter complexes and isoform‐specific activity of the bound HIF further contribute to selective patterns of gene activation. (embopress.org)
- A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (cathdb.info)
- Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. (cathdb.info)
- Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. (cathdb.info)
RUNX15
- runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl, and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche. (zfin.org)
- The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
- Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
- Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
- The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). (nih.gov)
Genes6
- To identify genes whose expressions in primary human trabecular meshwork (TM) cell cultures are affected by the transcription factor pituitary homeobox 2 (PITX2) and to identify genes that may have roles in glaucoma. (molvis.org)
- Figure 2 shows the results of the complete chromosome 3 and three genomic regions region surrounding the OGG1, FUT7 and NFE2 genes, respectively. (diagenode.com)
- These transcription factors regulate a host of genes specific to haematopoiesis (e.g. (diagenode.com)
- These chromosomal abnormalities tend to disrupt genes that encode for transcription factors needed for myeloid stem cells to differentiate into specific blood components. (the-medical-dictionary.com)
- Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA (towards the 3' region of the anti-sense strand ). (wikipedia.org)
- The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g. (nih.gov)
Allosterically enhances1
- it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. (nih.gov)
Beta9
- Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. (jax.org)
- These data demonstrate Runx transcription factors as a molecular link in TGF-beta-induced Foxp3 expression in iT reg cell differentiation and function. (nih.gov)
- In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit ( IPR002853 ) and the small beta ( IPR003166 ). (ebi.ac.uk)
- The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [ PMID: 10716934 ]. (ebi.ac.uk)
- RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa , a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
- The DNA binding complex compromises an oxygen‐regulated alpha‐subunit, which dimerizes with a constitutively expressed beta‐subunit and binds to cis‐ acting hypoxia response elements containing a core "RCGTG" consensus sequence [ 1 ], [ 2 ]. (embopress.org)
- BACKGROUND: SEG-1, a Barrett's-derived esophageal adenocarcinoma cell line, is not responsive to transforming growth factor beta (TGF-beta) growth effects. (duke.edu)
- Plasma testosterone level and steroidogenesis-related gene and protein (StAR, 3-beta-HSD, 17-beta-HSD) expressions, as well as mitochondrial membrane potential, were significantly decreased at high doses of SASP (in vivo). (bireme.br)
- In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. (nih.gov)
Holoenzyme1
- A sigma (σ) factor binds to the core, forming the holoenzyme. (wikipedia.org)
Regulation2
- Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. (jax.org)
- Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. (springer.com)
RUNX2
- This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. (abnova.com)
- RUNX 3, apoptosis 0: a new gastric tumour suppressor. (nih.gov)
Initiation factor2
- PREDICTED: transcription initiation factor TFIID subunit 4B-like[Cricetulus griseus]. (bioinformatics.org)
- PREDICTED: transcription initiation factor TFIID subunit 4-likeisoform 1 [Bombus impatiens]. (bioinformatics.org)
Family of transcription factors3
- A gene on chromosome 1p36 that encodes a member of the runt domain-containing family of transcription factors. (thefreedictionary.com)
- ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and maintenance of normal hematopoietic stem cells. (diagenode.com)
- Using a combined approach of positional cloning and transgenic (functional) rescue of the Clock mutation in mice, we found that the Clock gene encodes a novel member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. (hhmi.org)
Transcriptional6
- The first would be the initiation step, during which the RNA polymerase II (RNAPII) binds to the DNA site in order to form a preinitiation complex with other transcriptional factors. (wikibooks.org)
- The waxing and waning of this transcriptional feedback loop takes approximately 24 hours and represents the core mechanism of the circadian clock in mammals. (hhmi.org)
- Hypoxia‐inducible factor ( HIF ) directs an extensive transcriptional cascade that transduces numerous adaptive responses to hypoxia. (embopress.org)
- Preexisting long‐range interactions between HIF ‐binding sites and promoters as well as other enhancers shape the transcriptional architecture of the cellular response to hypoxia. (embopress.org)
- Hypoxia‐inducible factor (HIF) is the key transcription factor regulating transcriptional responses to hypoxia and is central to the pathogenesis of many human diseases including cancer. (embopress.org)
- Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. (dartmouth.edu)
Complex4
- The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. (abnova.com)
- Depending on the organism, a RNA polymerase can be a protein complex (multi-subunit RNAP) or only consist of one subunit (single-subunit SNAP, ssSNAP), each representing an independent lineage. (wikipedia.org)
- [4] [5] The core RNA polymerase complex forms a "crab claw" or "clamp-jaw" structure with an internal channel running along the full length. (wikipedia.org)
- Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (proteopedia.org)
Polymerases1
- [6] Eukaryotic and archaeal RNA polymerases have a similar core structure and work in a similar manner, although they have many extra subunits. (wikipedia.org)
Polyomavirus1
- The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). (uniprot.org)
Apoptosis2
- REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer. (labome.org)
- 01). SF has a protective effect by reducing the incidence of early steroid-induced femoral head necrosis in rabbits, effectively intervening in apoptosis through decreasing caspase-3 expression and up-regulating Bcl-2 expression. (labome.ru)
Chromosome1
- A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. (thefreedictionary.com)
Assays2
- Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. (bio-rad.com)
- Its effects on TF binding were investigated by electrophoretic mobility gel shift assays and chromatin immunoprecipitation. (ox.ac.uk)
Polypeptide1
- NS5A is a highly phosphorylated polypeptide that may be involved in resistance to the antiviral activity of alpha interferon ( 12 , 13 , 16 , 17 ). (asm.org)
Eukaryotes2
- The former is found in bacteria, archaea, and eukaryotes alike, sharing a similar core structure and mechanism. (wikipedia.org)
- Finally, RNA transcription in eukaryotes is also stimulated by the presence of enhancer sequences found in distant locations from the +1 region on either the 5' or 3' side. (wikibooks.org)
PMID1
- It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [ PMID: 10716934 ]. (ebi.ac.uk)
Differentiation2
- Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. (abcam.com)
- This transcription factor is responsible for the differentiation of precursor cells into osteoblasts and regulates the differentiation of chondrocytes in the growth plate [ 4 ]. (springer.com)
Bacterial2
- Comparative usefulness of inflammatory markers to indicate bacterial infection-analyzed according to blood culture results and related clinical factors. (springer.com)
- [2] Eukaryotic and archaeal RNAPs have more subunits than bacterial ones do, and are controlled differently. (wikipedia.org)
Fibroblast1
- Fibroblast growth factors. (dartmouth.edu)
Zinc1
- Binds these RNAs through its zinc fingers. (proteopedia.org)
Polymerase II core1
- Yeast RNA polymerase II core (PDB 1WCM). (wikipedia.org)
Phosphatidylinositol2
- This effect required the activation of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway, specifically PI(3)Kγ. (zfin.org)
- Insulin could inhibit the IkappaB phosphorylation, and then restrict NF-kappaB nuclear translocation and improve the vascular endothelial cells function accordingly through regulating phosphatidylinositol 3 kinase/Akt pathway. (labome.ru)
Omega1
- DNA-directed RNA polymerase, omega subunit / Sigma-54 factors family profile. (pdbj.org)
Antibody3
- By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be 1:8,800. (diagenode.com)
- MBS2702491 is a ready-to-use microwell, strip plate Double-antibody Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hypoxia Inducible Factor 1 Alpha (HIF1a) ELISA Kit target analytes in biological samples. (mybiosource.com)
- The microtiter plate provided in this kit has been pre-coated with an antibody specific to Hypoxia Inducible Factor 1 Alpha (HIF1a). (mybiosource.com)