Core binding factor alpha 2 subunit. Medical search

Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.

A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Myosin type II isoforms found in smooth muscle.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.

Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

The process of bone formation. Histogenesis of bone including ossification.

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Established cell cultures that have the potential to propagate indefinitely.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.

Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter. (1/859)

A cytogenetically cryptic (12;21) translocation is the most common molecular abnormality identified in childhood acute lymphoblastic leukemia (ALL), and it generates a chimeric TEL-AML1 protein. Fusion of the Helix-Loop-Helix (HLH) (also called the pointed) domain of TEL to AML1 has been suggested to convert AML1 from a transcriptional activator to a repressor. To define the structural features of this chimeric protein required for repression, we analysed the transcriptional activity of a series of TEL-AML1 mutants on the AML1-responsive interleukin-3 (IL-3) promoter, a potentially relevant gene target. Our results demonstrate that TEL-AML1 represses basal IL-3 promoter activity in lymphoid cells, and deletion mutant analysis identified three distinct domains of TEL-AML1 that are required for repression; the HLH (pointed) motif contained in the TEL portion of TEL-AML1, and both the runt homology domain (Rhd) and the 74 amino acids downstream of the Rhd that are present in the AML1 portion of the fusion protein. Although AML1B (and a shorter AML1 isoform, AML1A) have transcriptional activating activity on the IL-3 promoter, fusion of the AML1 gene to the TEL gene generates a repressor of IL-3 expression. Consistent with this activity, freshly isolated human ALL cells that contain TEL-AML1 do not express IL-3. (+info)

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. (2/859)

The AML1 gene encoding the DNA-binding alpha-subunit in the Runt domain family of heterodimeric transcription factors has been noted for its frequent involvement in chromosomal translocations associated with leukemia. Using reverse transcriptase-polymerase chain reaction (RT-PCR) combined with nonisotopic RNase cleavage assay (NIRCA), we found point mutations of the AML1 gene in 8 of 160 leukemia patients: silent mutations, heterozygous missense mutations, and biallelic nonsense or frameshift mutations in 2, 4, and 2 cases, respectively. The mutations were all clustered within the Runt domain. Missense mutations identified in 3 patients showed neither DNA binding nor transactivation, although being active in heterodimerization. These defective missense mutants may be relevant to the predisposition or progression of leukemia. On the other hand, the biallelic nonsense mutants encoding truncated AML1 proteins lost almost all functions examined and may play a role in leukemogenesis leading to acute myeloblastic leukemia. (+info)

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. (3/859)

The transcription factors Ets-1 and AML1 (the alphaBl subunit of PEBP2/CBF) play critical roles in hematopoiesis and leukemogenesis, and cooperate in the transactivation of the T cell receptor (TCR) beta chain enhancer. The DNA binding capacity of both factors is blocked intramolecularly but can be activated by the removal of negative regulatory domains. These include the exon VII domain for Ets-1 and the negative regulatory domain for DNA binding (NRDB) for alphaB1. Here we report that the direct interaction between the two factors leads to a reciprocal stimulation of their DNA binding activity and activation of their transactivation function. Detailed mapping revealed two independent contact points involving the exon VII and NRDB regions as well as the two DNA binding domains. Using deletion variants and dominant interfering mutants, we demonstrate that the interaction between exon VII and NRDB is necessary and sufficient for cooperative DNA binding. The exon VII and NRDB motifs are highly conserved in evolution yet deleted in natural variants, suggesting that the mechanism described is of biological relevance. The mutual activation of DNA binding of Ets and AML1 through the intermolecular interaction of autoinhibitory domains may represent a novel principle for the regulation of transcription factor function. (+info)

A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. (4/859)

Using PCR-coupled subtractive screening-representational difference analysis, we have cloned a novel gene from AML1-ETO knockin mice. This gene is highly expressed in the yolk sac and fetal liver of the knockin mice. Nucleotide sequence analysis indicates that its cDNA contains an 1,107-bp open reading frame encoding a 368-amino-acid polypeptide. Further protein sequence and protein translation analysis shows that it belongs to a family of ubiquitin-specific proteases (UBP), and its molecular mass is 43 kDa. Therefore, we have named this gene UBP43. Like other ubiquitin proteases, the UBP43 protein has deubiquitinating enzyme activity. Protein ubiquitination has been implicated in many important cellular events. In wild-type adult mice, UBP43 is highly expressed in the thymus and in peritoneal macrophages. Among nine different murine hematopoietic cell lines analyzed, UBP43 expression is detectable only in cell lines related to the monocytic lineage. Furthermore, its expression is regulated during cytokine-induced monocytic cell differentiation. We have investigated its function in the hematopoietic myeloid cell line M1. UBP43 was introduced into M1 cells by retroviral gene transfer, and several high-expressing UBP43 clones were obtained for further study. Morphologic and cell surface marker examination of UBP43/M1 cells reveals that overexpression of UBP43 blocks cytokine-induced terminal differentiation of monocytic cells. These data suggest that UBP43 plays an important role in hematopoiesis by modulating either the ubiquitin-dependent proteolytic pathway or the ubiquitination state of another regulatory factor(s) during myeloid cell differentiation. (+info)

Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1. (5/859)

Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. (+info)

Solution properties of the free and DNA-bound Runt domain of AML1. (6/859)

The Runt domain is responsible for specific DNA and protein-protein interactions in a family of transcription factors which includes human AML1. Structural data on the Runt domain has not yet become available, possibly due to solubility and stability problems with expressed protein fragments. Here we describe the optimization and characterization of a 140-residue fragment, containing the Runt domain of AML1, which is suitable for structural studies. The fragment of AML1 including amino acids 46-185 [AML1 Dm(46-185)] contains a double cysteine-->serine mutation which does not affect Runt domain structure or DNA-binding affinity. Purified AML1 Dm(46-185) is soluble and optimally stable in a buffer containing 200 mm MgSO4 and 20 mm sodium phosphate at pH 6.0. Nuclear magnetic resonance and circular dichroism spectroscopy indicate that the Runt domain contains beta-sheet, but little or no alpha-helical secondary structure elements. The 45 N-terminal residues of AML1 are unstructured and removal of the N-terminal enhances sequence-specific DNA binding. The NMR spectrum of AML1 Dm(46-185) displays a favorable chemical shift dispersion and resolved NOE connectivities are readily identified, suggesting that a structure determination of this Runt domain fragment is feasible. A titration of 15N-labelled AML1 Dm(46-185) with a 14-bp cognate DNA duplex results in changes in the 15N NMR heteronuclear single quantum coherence spectrum which indicate the formation of a specific complex and structural changes in the Runt domain upon DNA binding. (+info)

Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8. (7/859)

The translocation (8;21)(q22;q22) is a karyotypic abnormality detected in acute myeloid leukaemia (AML) M2 and results in the formation of the chimeric fusion gene AML1/MTG8. We previously reported that two hammerhead ribozymes against AML1/MTG8 cleave this fusion transcript and also inhibit the proliferation of myeloid leukaemia cell line Kasumi-1 which possesses t(8;21)(q22;q22). In this study, we investigated the mechanisms of inhibition of proliferation in myeloid leukaemic cells with t(8;21)(q22;q22) by ribozymes. These ribozymes specifically inhibited the growth of Kasumi-1 cells, but did not affect the leukaemic cells without t(8;21)(q22;q22). We observed the morphological changes including chromatin condensation, fragmentation and the formation of apoptotic bodies in Kasumi-1 cells incubated with ribozymes for 7 days. In addition, DNA ladder formation was also detected after incubation with ribozymes which suggested the induction of apoptosis in Kasumi-1 cells by the AML1/MTG8 ribozymes. However, the ribozymes did not induce the expression of CD11b and CD14 antigens in Kasumi-1 cells. The above data suggest that these ribozymes therefore inhibit the growth of myeloid leukaemic cells with t(8;21)(q22;q22) by the induction of apoptosis, but not differentiation. We conclude therefore that the ribozymes targeted against AML1/MTG8 may have therapeutic potential for patients with AML carrying t(8;21)(q22;q22) while, in addition, the product of the chimeric gene is responsible for the pathogenesis of myeloid leukaemia. (+info)

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation. (8/859)

The human AML1 gene encodes a heterodimeric transcription factor which plays an important role in mammalian hematopoiesis. Several alternatively spliced AML1 mRNA species were identified, some of which encode short protein products that lack the transactivation domain. When transfected into cells these short isoforms dominantly suppress transactivation mediated by the full length AML1 protein. However, their biological function remains obscure. To investigate the role of these short species in cell proliferation and differentiation we generated embryonic stem (ES) cells overexpressing one of the short isoforms, AML1-d, as well as cells expressing the full length isoforms AML1-b and AML2. The in vitro growth rate and differentiation of the transfected ES cells were unchanged. However, overexpression of AML1-d significantly affected the ES cells' ability to form teratocarcinomas in vivo in syngeneic mice, while a similar overexpression of AML1-b and AML2 had no effect on tumor formation. Histological analysis revealed that the AML1-d derived tumors were poorly differentiated and contained numerous apoptotic cells. These data highlight the pleiotropic effects of AML1 gene products and demonstrate for the first time an in vivo growth regulation function for the short isoform AML1-d. (+info)

Inversions are classified based on their location along the chromosome:

* Interstitial inversion: A segment of DNA is reversed within a larger gene or group of genes.
* Pericentric inversion: A segment of DNA is reversed near the centromere, the region of the chromosome where the sister chromatids are most closely attached.

Chromosome inversions can be detected through cytogenetic analysis, which allows visualization of the chromosomes and their structure. They can also be identified using molecular genetic techniques such as PCR (polymerase chain reaction) or array comparative genomic hybridization (aCGH).

Chromosome inversions are relatively rare in the general population, but they have been associated with various developmental disorders and an increased risk of certain diseases. For example, individuals with an inversion on chromosome 8p have an increased risk of developing cancer, while those with an inversion on chromosome 9q have a higher risk of developing neurological disorders.

Inversions can be inherited from one or both parents, and they can also occur spontaneously as a result of errors during DNA replication or repair. In some cases, inversions may be associated with other genetic abnormalities, such as translocations or deletions.

Overall, chromosome inversions are an important aspect of human genetics and can provide valuable insights into the mechanisms underlying developmental disorders and disease susceptibility.

AML is a fast-growing and aggressive form of leukemia that can spread to other parts of the body through the bloodstream. It is most commonly seen in adults over the age of 60, but it can also occur in children.

There are several subtypes of AML, including:

1. Acute promyelocytic leukemia (APL): This is a subtype of AML that is characterized by the presence of a specific genetic abnormality called the PML-RARA fusion gene. It is usually responsive to treatment with chemotherapy and has a good prognosis.
2. Acute myeloid leukemia, not otherwise specified (NOS): This is the most common subtype of AML and does not have any specific genetic abnormalities. It can be more difficult to treat and has a poorer prognosis than other subtypes.
3. Chronic myelomonocytic leukemia (CMML): This is a subtype of AML that is characterized by the presence of too many immature white blood cells called monocytes in the blood and bone marrow. It can progress slowly over time and may require ongoing treatment.
4. Juvenile myeloid leukemia (JMML): This is a rare subtype of AML that occurs in children under the age of 18. It is characterized by the presence of too many immature white blood cells called blasts in the blood and bone marrow.

The symptoms of AML can vary depending on the subtype and the severity of the disease, but they may include:

* Fatigue
* Weakness
* Shortness of breath
* Pale skin
* Easy bruising or bleeding
* Swollen lymph nodes, liver, or spleen
* Bone pain
* Headache
* Confusion or seizures

AML is diagnosed through a combination of physical examination, medical history, and diagnostic tests such as:

1. Complete blood count (CBC): This test measures the number and types of cells in the blood, including red blood cells, white blood cells, and platelets.
2. Bone marrow biopsy: This test involves removing a small sample of bone marrow tissue from the hipbone or breastbone to examine under a microscope for signs of leukemia cells.
3. Genetic testing: This test can help identify specific genetic abnormalities that are associated with AML.
4. Immunophenotyping: This test uses antibodies to identify the surface proteins on leukemia cells, which can help diagnose the subtype of AML.
5. Cytogenetics: This test involves staining the bone marrow cells with dyes to look for specific changes in the chromosomes that are associated with AML.

Treatment for AML typically involves a combination of chemotherapy, targeted therapy, and in some cases, bone marrow transplantation. The specific treatment plan will depend on the subtype of AML, the patient's age and overall health, and other factors. Some common treatments for AML include:

1. Chemotherapy: This involves using drugs to kill cancer cells. The most commonly used chemotherapy drugs for AML are cytarabine (Ara-C) and anthracyclines such as daunorubicin (DaunoXome) and idarubicin (Idamycin).
2. Targeted therapy: This involves using drugs that specifically target the genetic abnormalities that are causing the cancer. Examples of targeted therapies used for AML include midostaurin (Rydapt) and gilteritinib (Xospata).
3. Bone marrow transplantation: This involves replacing the diseased bone marrow with healthy bone marrow from a donor. This is typically done after high-dose chemotherapy to destroy the cancer cells.
4. Supportive care: This includes treatments to manage symptoms and side effects of the disease and its treatment, such as anemia, infection, and bleeding. Examples of supportive care for AML include blood transfusions, antibiotics, and platelet transfusions.
5. Clinical trials: These are research studies that involve testing new treatments for AML. Participating in a clinical trial may give patients access to innovative therapies that are not yet widely available.

It's important to note that the treatment plan for AML is highly individualized, and the specific treatments used will depend on the patient's age, overall health, and other factors. Patients should work closely with their healthcare team to determine the best course of treatment for their specific needs.

https://www.medicinenet.com › Medical Dictionary › G

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

Genetic Translocation | Definition & Facts | Britannica
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Genetic translocation, also called chromosomal translocation, a type of chromosomal aberration in which a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material. Genetic translocations are often found in cancer cells and may play a role in the development and progression of cancer.

Translocation, Genetic | health Encyclopedia - UPMC
https://www.upmc.com › health-library › gene...

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

Genetic Translocation | Genetics Home Reference - NIH
https://ghr.nlm.nih.gov › condition › ge...

A genetic translocation is a change in the number or arrangement of the chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome. This can result in a gain or loss of genetic material, which can have significant effects on the individual.

In conclusion, Genetic Translocation is an abnormality in the number or arrangement of chromosomes in a cell. It occurs when a portion of one chromosome breaks off and attaches to another chromosome, resulting in a gain or loss of genetic material that can have significant effects on the individual.

Myeloid leukemia can be classified into several subtypes based on the type of cell involved and the degree of maturity of the abnormal cells. The most common types of myeloid leukemia include:

1. Acute Myeloid Leukemia (AML): This is the most aggressive form of myeloid leukemia, characterized by a rapid progression of immature cells that do not mature or differentiate into normal cells. AML can be further divided into several subtypes based on the presence of certain genetic mutations or chromosomal abnormalities.
2. Chronic Myeloid Leukemia (CML): This is a slower-growing form of myeloid leukemia, characterized by the presence of a genetic abnormality known as the Philadelphia chromosome. CML is typically treated with targeted therapies or bone marrow transplantation.
3. Myelodysplastic Syndrome (MDS): This is a group of disorders characterized by the impaired development of immature blood cells in the bone marrow. MDS can progress to AML if left untreated.
4. Chronic Myelomonocytic Leukemia (CMML): This is a rare form of myeloid leukemia that is characterized by the accumulation of immature monocytes in the blood and bone marrow. CMML can be treated with chemotherapy or bone marrow transplantation.

The symptoms of myeloid leukemia can vary depending on the subtype and severity of the disease. Common symptoms include fatigue, weakness, fever, night sweats, and weight loss. Diagnosis is typically made through a combination of physical examination, blood tests, and bone marrow biopsy. Treatment options for myeloid leukemia can include chemotherapy, targeted therapies, bone marrow transplantation, and supportive care to manage symptoms and prevent complications. The prognosis for myeloid leukemia varies depending on the subtype of the disease and the patient's overall health. With current treatments, many patients with myeloid leukemia can achieve long-term remission or even be cured.

Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi ...

https://en.wikipedia.org/wiki/CBFA2T3

"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... Transcription factors, All stub articles, Human chromosome 20 gene stubs). ... 18 (2): 846-58. doi:10.1128/MCB.18.2.846. PMC 108796. PMID 9447981. Fracchiolla NS, Colombo G, Finelli P, Maiolo AT, Neri A ( ...

https://en.wikipedia.org/wiki/CBFA2T2

... also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. The Runx2 DNA-binding activity is correlated with ...

https://en.wikipedia.org/wiki/RUNX2

... or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. RUNX1 is a ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...

https://en.wikipedia.org/wiki/RUNX1

The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 ... The conserved region contains four alpha helices and three loops arranged as in histone H3. TAF11 has been shown to interact ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ...

https://en.wikipedia.org/wiki/TAF11

... it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and ... Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...

https://en.wikipedia.org/wiki/CBFB

Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... subunits) binds a sigma factor to form a complex called the RNA polymerase holoenzyme. It was previously believed that the RNA ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ...

https://en.wikipedia.org/wiki/Sigma_factor

"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... Binding of IL-12 to IL-12R, which is composed of two different subunits (IL12Rβ1 and IL12Rβ2), leads to the interaction of ... "Increased sensitivity to interferon-alpha in psoriatic T cells". The Journal of Investigative Dermatology. 125 (5): 936-44. doi ... association with regulatory factors; 3. central DNA-binding domain - binding to the enhancer region of IFN-γ activated sequence ...

https://en.wikipedia.org/wiki/STAT4

Selective factor 1 is composed of the TATA-binding protein and three TAF (TATA box-binding protein-associated factor) subunits ... It contains two short alpha helices and a long central alpha helix. TAF1 (TAFII250) TAF2 (CIF150) TAF3 (TAFII140) TAF4 ( ... for example the downstream promoter element or gene-specific core promoter sequence Due to such interactions, they contribute ... The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a ...

https://en.wikipedia.org/wiki/TBP-associated_factor

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...

https://en.wikipedia.org/wiki/GTF2A1L

These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... The first domain (A1) contains 20 amino acids that forms an alpha helix that appears significant in its interactions with NF-YB ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...

https://en.wikipedia.org/wiki/CAAT_box

This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...

https://en.wikipedia.org/wiki/SEC61B

The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a ... This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and ... TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription ...

https://en.wikipedia.org/wiki/TAF15

Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...

https://en.wikipedia.org/wiki/Sec61_alpha_1

One species that looked at is Drosophila, and in the subunits of the Drosophila transcription initiation factor has specific ... conserved motif found near the C-terminus in every core histone sequence in a histone octamer responsible for the binding of ... The histone fold averages about 70 amino acids and consists of three alpha helices connected by two short, unstructured loops. ... Also the histone fold was first found in TATA box-binding protein-associated factors, which is a main component in ...

https://en.wikipedia.org/wiki/Histone_fold

In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... "Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases". Structure. 17 (7): 981-9. ... The catalytic domain consists of a double-stranded β-helix core that is stabilized by three α-helices packed along the major β- ... X-ray crystallography and NMR spectroscopy showed that both peptides bind to the same binding site on PHD2, in a cleft on the ...

https://en.wikipedia.org/wiki/EGLN1

... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β′ The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...

https://en.wikipedia.org/wiki/RNA_polymerase

... a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 ... "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD10

"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599-606. doi:10.1006/jmbi. ... "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655-66. ... The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of ...

https://en.wikipedia.org/wiki/POLR2J

"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... The W2 domain has a globular fold and is exclusively composed out of alpha-helices. ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ...

https://en.wikipedia.org/wiki/EIF-W2_protein_domain

"The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative ... which interacts with the seven-membered alpha ring of 20S core particle and establishes an asymmetric interface between the 19S ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...

https://en.wikipedia.org/wiki/PSMC5

November 1993). "A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase". ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ...

https://en.wikipedia.org/wiki/Promoter_(genetics)

This contains a core of two compact domains with each having five alpha helices. The first five-helix bundle is a conserved ... Viral cyclin D binds human Cdk6 and inhibits Rb by phosphorylating it, resulting in free transcription factors which result in ... A simplification in yeast is that all cyclins bind to the same Cdc subunit, the Cdc28. Cyclins in yeast are controlled by ... A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast ...

https://en.wikipedia.org/wiki/Cyclin_D

This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several ... The protein complex that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to ... "Induced alpha helix in the VP16 activation domain upon binding to a human TAF". Science. 277 (5330): 1310-3. doi:10.1126/ ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ...

https://en.wikipedia.org/wiki/TAF9

The smaller subunit of this Damaged DNA Binding protein complex is known as DDB2 and is able to directly bind DNA lesions ... Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ... RBX1 is a core component of Cullin-RING ubiquitin ligase (CRL) complexes and functions to recruit E2 ubiquitin conjugating ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ...

https://en.wikipedia.org/wiki/CUL4A

The core enzyme of RNA polymerase has five subunits (protein subunits) (~400 kDa). Because of the RNA polymerase association ... with sigma factor, the complete RNA polymerase therefore has 6 subunits: the sigma subunit-in addition to the two alpha (α), ... also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter ... The RNA polymerase core associates with the sigma factor to form RNA polymerase holoenzyme. Sigma factor reduces the affinity ...

https://en.wikipedia.org/wiki/General_transcription_factor

... which include two alphas, a beta, and a beta prime (α, α, β, and β'). A fifth subunit, sigma (called the σ-factor), is only ... The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ...

https://en.wikipedia.org/wiki/Bacterial_transcription

Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits ... "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes". Proc. Natl. ... "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97-105. ... "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355-63. doi: ...

https://en.wikipedia.org/wiki/SMARCC2

Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and ... 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure ... Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ...

https://en.wikipedia.org/wiki/PPP2R1A

... general transcription factor 2H subunit 5) is also known as the TTD group A (TTDA) subunit (and as Tfb5). The TTDA subunit is ... and part of a six-subunit complex of Rad3, Tfb1, Tfb2, Tfb4, Tfb5, and Ssl1 (referred to as core) In humans, the function of ... TTDA is present both bound to TFIIH, and as a free fraction that shuffles between the cytoplasm and nucleus; induction of NER- ... 2012). "Subunit architecture of general transcription factor TFIIH". Proc Natl Acad Sci U S A. 109 (6): 1949-54. Bibcode: ...

https://en.wikipedia.org/wiki/Tbf5_protein_domain

... a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD7

However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... "Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the ... The role of alpha and beta isoforms of the glucocorticoid receptor]". Archivos de Bronconeumologia. 38 (9): 436-440. doi: ... hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors ...

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

Alongside alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i "Entrez ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...

https://en.wikipedia.org/wiki/PSMB3

2002). "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV ... Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ... 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97 ... 2002). "The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 ...

https://en.wikipedia.org/wiki/DDB1

... encoding protein Polyamine-modulated factor 1-binding protein 1 POLR3K: encoding enzyme DNA-directed RNA polymerase III subunit ... encoding protein VPS35 Endosomal Protein Sorting Factor Like WFDC1: encoding protein WAP four-disulfide core domain protein 1 ... alpha pseudogene 1 HBHR, ATR1: Alpha-thalassemia/mental retardation syndrome, type 1 HIRIP3: encoding protein HIRA-interacting ... encoding protein SHC SH2 domain-binding protein 1 SLZ1: encoding protein SLX1 structure-specific endonuclease subunit homolog B ...

https://en.wikipedia.org/wiki/Chromosome_16

... with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit ... is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11916-20. doi: ... a pheromone desensitization factor in Saccharomyces cerevisiae". Mol Cell Biol. 15 (7): 3635-43. doi:10.1128/MCB.15.7.3635. PMC ... G protein gamma subunit-like) for binding G protein beta subunits (InterPro: IPR001770 Those RGS proteins that contain GGL ...

https://en.wikipedia.org/wiki/Regulator_of_G_protein_signaling

Expression of lymphoid enhancer-binding factor 1 (LEF-1) triggers the translocation of β-catenin to the nucleus, where it ... Protocadherin-alpha and protocadherin-gamma interact to form a protein complex that enhances the surface expression of each ... Davis, MA; Ireton, RC; Reynolds, AB (2003). "A core Function for p120-catenin in cadherin turnover". J. Cell Biol. 163 (3): 525 ... impaired the stabilization of GluR2 and GluR3 AMPAR subunits, respectively, at the plasma membrane. Co-localization of p120ctn ...

https://en.wikipedia.org/wiki/Cadherin–catenin_complex_in_learning_and_memory

These core histones are rich in lysine and arginine residues. The carboxyl (C) terminal end of these histones contribute to ... It results in good optimization and is used in vivo to reveal DNA-protein binding occurring in cells. ChIP-Seq can be used to ... H4K8ac indicates acetylation of lysine 8 on histone H4 protein subunit: The genomic DNA of eukaryotic cells is wrapped around ... Maruta H, Greer K, Rosenbaum JL (1986). "The acetylation of alpha-tubulin and its relationship to the assembly and disassembly ...

https://en.wikipedia.org/wiki/H4K8ac

p53 is unique as a transcription factor in that it can recognize and bind response elements (RE) in many different environments ... One of the two molecules of this complex is multimeric alpha lactalbumin (MAL) (Figure 3), which was first discovered during a ... "Identification of a Unique Core Domain of Par-4 Sufficient for Selective Apoptosis Induction in Cancer Cells". Molecular and ... that the mechanisms behind the function of E4orf4 is closely associated with several other proteins including the B55 subunit ...

https://en.wikipedia.org/wiki/Anticancer_gene

Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex ... Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (March 1999). "A novel ubiquitination factor, E4, is involved in ... This is a barrel-shape structure comprising a central proteolytic core made of four ring structures, flanked by two cylinders ... alpha} via the N-terminal pathway". The Journal of Biological Chemistry. 285 (51): 40192-200. doi:10.1074/jbc.M110.131615. PMC ...

https://en.wikipedia.org/wiki/Ubiquitin

... a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 ... Deveraux Q, Ustrell V, Pickart C, Rechsteiner M (1994). "A 26 S protease subunit that binds ubiquitin conjugates". J. Biol. ... "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ...

https://en.wikipedia.org/wiki/PSMD5

Synaptobrevin binds the α-helix near the C-terminus of SNAP-25, while syntaxin-1 binds the α-helix near the N-terminus. ... The core symptoms comprise intellectual disability ranging between mild to profound and early-onset seizures mostly occurring ... Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a ... Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein ...

https://en.wikipedia.org/wiki/SNAP25

Leiser SC, Bowlby MR, Comery TA, Dunlop J (June 2009). "A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is ... FABP7, coding the Fatty acid-binding protein 7 (brain), one SNP of which was associated with schizophrenia in one 2008 study, ... Alderson RM, Rapport MD, Hudec KL, Sarver DE, Kofler MJ (May 2010). "Competing core processes in attention-deficit/ ... CHRNA7, coding the neuronal nicotinic acetylcholine receptor alpha7 subunit. alpha7-containing receptors are known to improve ...

https://en.wikipedia.org/wiki/Endophenotype

The subunit Rpn12 incorporated into 19S regulatory particle when 19S lid and base bind together. Among these lid subunits, ... as well as to cause conformational changes to the alpha subunit C-terminals that form the substate entrance of the 20S complex ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... The 26S proteasome complex usually consists of a 20S core particle (CP, or 20S proteasome) and one or two 19S regulatory ...

https://en.wikipedia.org/wiki/PSMD14

Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... The Gβγ subunit has been shown to activate a Rho guanine nucleotide exchange factor (RhoGef) gene PLEKHG2 which is upregulated ... N terminus helical domains of the two subunits form a coiled coil with one another that typically extends away from the core of ... The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ...

https://en.wikipedia.org/wiki/G_beta-gamma_complex

"Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ... MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh ... encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core ... "Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ...

https://en.wikipedia.org/wiki/Homeobox_protein_MSX-1

Akiba S, Hatazawa R, Ono K, Hayama M, Matsui H, Sato T (Nov 2000). "Transforming growth factor-alpha stimulates prostaglandin ... Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... Munz B, Gerke V, Gillitzer R, Werner S (Mar 1997). "Differential expression of the calpactin I subunits annexin II and p11 in ... by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. The ...

https://en.wikipedia.org/wiki/S100A10

... which is initiated by ligands binding to G protein-coupled receptors activating the Gq alpha subunit. PtdIns(4,5)P2 is a ... Some of the factors involved in PIP2 regulation are: Lipid kinases, Lipid Phosphatase Lipid Transfer Proteins Growth Factors, ... 2004). "CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP 2 binding protein". Neuron. 43 (4): 551-562. ... PtdIns(4,5)P2 has been shown to stabilize the active states of Class A G protein-coupled receptors (GPCRs) via direct binding, ...

https://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate

In this process, Cables 1 mechanistically interferes the proteasome subunit alpha type-3 (PMSA3) hereby binding to p21 to ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ...

https://en.wikipedia.org/wiki/PSMA3

In the hexameric configuration, the ATP-binding site is positioned at the interface between the subunits. Upon ATP binding and ... an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold) and a C-terminal alpha-helical domain. ... AAA proteins are divided into seven basic clades, based on secondary structure elements included within or near the core AAA ... "Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP". Nat. Struct. ...

https://en.wikipedia.org/wiki/AAA_proteins

... the alpha helix). Linus Pauling was the first to identify the 3.6 amino acids per helix turn ratio of the alpha helix. Crick ... It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... one factor being that the new college did not have a chapel. Some time later a large donation was made to establish a chapel ...

https://en.wikipedia.org/wiki/Francis_Crick

... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity. Multidomain cellulases are ... McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-β-D-glucanase". ... construction of the catalytic core, expression, and X-ray structure at 1.75 Å resolution". Biochemistry. 36 (51): 16032-9. doi: ...

https://en.wikipedia.org/wiki/Cellulase

... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... The SeV virion also contains the nucleocapsid core, which is composed of the genomic RNA, the nucleocapsid protein (NP), the ... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ...

https://en.wikipedia.org/wiki/Murine_respirovirus

Since 56Ni (14 alpha particles) is easily produced from lighter nuclei in the alpha process in nuclear reactions in supernovae ... As such, iron is the most abundant element in the core of red giants, and is the most abundant metal in iron meteorites and in ... Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... The ensuing availability of inexpensive iron was one of the factors leading to the Industrial Revolution. Toward the end of the ...

https://en.wikipedia.org/wiki/Iron

Proteasome subunit beta type-10 is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and ... that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...

https://en.wikipedia.org/wiki/PSMB10

... transfer factor MeSH D12.776.467.374.500.400 - interleukin-1 MeSH D12.776.467.374.500.800 - tumor necrosis factor-alpha MeSH ... lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800.750 - t cell transcription factor 1 MeSH D12.776.664.962. ... hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, gag-pol MeSH D12.776.964.775.375.335 - hiv integrase MeSH ... immunoglobulin subunits MeSH D12.776.377.715.548.705.500 - immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

... epithelium-specific Ets transcription factor 1-S207, ErbB3 binding protein 1-T261, nuclear receptor-interacting factor 3-S28, ... The core domains of the PAK family include a kinase domain in the C-terminal region, a p21-binding domain (PBD), and an auto- ... Estrogen receptor-alpha-S305, signal transducer and activator of transcription 5a-S779, C-terminal binding protein 1-S158, Raf1 ... Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R (February 2004). "p41-Arc subunit of human Arp2/3 complex is a p21- ...

https://en.wikipedia.org/wiki/PAK1

... is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus ... The core elements of the SL3 virus are im … ... also known as polyomavirus enhancer-binding protein 2 and SL3 ... Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores A L ... Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores A L ...

https://pubmed.ncbi.nlm.nih.gov/7707514

core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related ... The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). As part of CBF ... Core binding factor acute myeloid leukemia. A rearrangement (translocation) of genetic material involving the RUNX1T1 gene is ... Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2): ...

https://medlineplus.gov/genetics/gene/runx1t1/

... or by conversion of one differentiated cell type into another by enforced expression of master transcription factors. Here, to ... Core Binding Factor Alpha 2 Subunit / metabolism Actions. * Search in PubMed * Search in MeSH ... In vivo factor-minus-one analysis of defined seven transcription factors to identify necessary and redundant factors. Bone ... e, Factor-minus-one approach to define essential transcription factors for engraftment. Haemogenic endothelium was infected ...

https://www.ncbi.nlm.nih.gov/pubmed/28514439

MeSH Terms: Animals; Core Binding Factor Alpha 2 Subunit/physiology*; Gene Expression Regulation, Neoplastic; Histone-Lysine N- ... alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism*; Hypoxia-Inducible Factor 1, alpha Subunit/ ... Here, we show that hypoxia-independent activation of hypoxia-inducible factor 1α (HIF1A) signaling is both necessary and ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3488140

Paeonolide as a Novel Regulator of Core-Binding Factor Subunit Alpha-1 in Bone-Forming Cells.. Park KR; Lee JY; Cho M; Hong JT ... 3. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor.. Park KR; ... 4. Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and ... Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts.. Kanno T; Takahashi T; ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=33829967&mod=related&page=1&outid=&proj=

SL3/AKV core-binding factor alpha C subunit. Description. RUNX3 is a member of the runt domain-containing family of ... transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5- ... It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or ... we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. The centers ...

https://edrn.nci.nih.gov/data-and-resources/biomarkers/runx3/

Core Binding Factors [D12.776.930.155] * Core Binding Factor alpha Subunits [D12.776.930.155.200] * Core Binding Factor Alpha 1 ... A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It ... A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It ... Core Binding Factor Alpha 2 Subunit Preferred Term Term UI T575929. Date03/08/2004. LexicalTag NON. ThesaurusID NLM (2006). ...

https://meshb.nlm.nih.gov/record/ui?ui=D050676

Core Binding Factor Alpha 1 Subunit [D12.776.930.155.200.100] Core Binding Factor Alpha 1 Subunit ... A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It ... A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It ... Core Binding Factor Alpha 2 Subunit Descriptor Spanish: Subunidad alfa 2 del Factor de Unión al Sitio Principal Spanish from ...

https://decs.bvsalud.org/en/ths/resource/?id=51177

https://meshb-prev.nlm.nih.gov/record/ui?ui=D050676

Core Binding Factor Alpha 2 Subunit (1) * High-Throughput Nucleotide Sequencing (1) ...

https://pesquisa.bvsalud.org/perinatal/?lang=en&q=au:Dawson-Meadows,+Alison

Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit ... Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit ... the FTZ-F1 helix along with the core DBD serves as a platform for interactions with coactivators and other DNA-bound factors in ... SF1 forms a specific complex with the DNA through a bipartite motif binding to the major and minor grooves through the core DBD ...

https://www.rcsb.org/structure/2FF0

Core Binding Factor Alpha 2 Subunit 61% * Drosophila Proteins 52% * DNA 38% ...

https://experts.syr.edu/en/publications/conservation-and-function-of-the-transcriptional-regulatory-prote/fingerprints/

core-binding factor, runt domain, alpha subunit 2; translocated to, 3 HGNC id 1537 ... core binding. REGULATION ASSOCIATED DISORDERS. corresponding disease(s) Other morbid association(s) Type. Gene Modification. ... transcription factor , tumor suppressor SUBCELLULAR LOCALIZATION intracellular intracellular,cytoplasm,organelle,membrane ... RUNX1T1 and CBFA2T3, are fused to the DNA-binding domain of AML1, a transcriptional activator crucial for hematopoiesis ...

http://genatlas.medecine.univ-paris5.fr/fiche.php?symbol=CBFA2T3

Core Binding Factor Alpha 2 Subunit Medicine & Life Sciences 40% * Multivariate Analysis Medicine & Life Sciences 32% ... 60.8%, p = 0.62). Multivariate analysis identified age, donor type and poor cytogenetics as risk factors for inferior outcome. ... 60.8%, p = 0.62). Multivariate analysis identified age, donor type and poor cytogenetics as risk factors for inferior outcome. ... 60.8%, p = 0.62). Multivariate analysis identified age, donor type and poor cytogenetics as risk factors for inferior outcome. ...

https://cris.tau.ac.il/en/publications/allogeneic-stem-cell-transplantation-for-aml-patients-with-runx1-

Core Binding Factor Alpha 2 Subunit * Leukemia, Myeloid, Acute * DNA-Binding Proteins ...

https://connects.catalyst.harvard.edu/Profiles/display/Person/172960/Network/SimilarTo

core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) ENSMUSG00000038533 O70374 ... core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) ENSMUSG00000006362 O54972 ... chromatin assembly factor 1, subunit B (p60) ENSMUSG00000022945 Q9D0N7 Chd7 chromodomain helicase DNA binding protein 7 ... pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 ENSMUSG00000020098 ...

https://esbl.nhlbi.nih.gov/Databases/KSBP2/Targets/Lists/Co-Regulators/

Animals, Cell Differentiation, Core Binding Factor Alpha 2 Subunit, Embryonic Development, Hematopoietic Stem Cells, Humans, ... If you click Reject all non-essential cookies only necessary cookies providing core functionality such as security, network ...

https://www.cardioscience.ox.ac.uk/publications/106305

CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding ... A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. ... HN - 2006(1987) BX - Core Binding Factor alpha Proteins MH - Core Binding Factor beta Subunit UI - D050658 MN - D12.776.930.155 ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/.bkup/mshnew2006.10-03-2005.txt

This subunit forms the core of the heterotrimer. The alpha and beta subunits bind the gamma, but do not interact together. ... Furthermore, the isolated C-domain of aIF2alpha is responsible for binding of the alpha subunit to gamma. This binding involves ... aIF2gamma shows a high resemblance with elongation factor EF1-A. In this study, we characterize the role of each subunit in the ... Site-directed mutagenesis confirms a binding mode of the tRNA molecule similar to that observed with the elongation factor. ...

https://hal-polytechnique.archives-ouvertes.fr/hal-00770710v1

The transcription factor Runx1 is a pivotal regulator of definitive hematopoiesis in mouse ontogeny. Vertebrate Runx1 is ... transcribed from 2 promoters, the distal P1 and proximal P2, which provide a paradigm of the complex transcriptional and ... Core Binding Factor Alpha 2 Subunit, Embryo Loss, Embryo, Mammalian, Gene Expression Regulation, Developmental, Genes, Reporter ... The transcription factor Runx1 is a pivotal regulator of definitive hematopoiesis in mouse ontogeny. Vertebrate Runx1 is ...

https://www.rdm.ox.ac.uk/publications/255694?d9133838-fe00-11ed-be50-064cbb69e63c

... core-binding factor subunit alpha-1/Runt-related transcription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin ... core-binding factor subunit alpha-1/Runt-related transcription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin ... core-binding factor subunit alpha-1/Runt-related transcription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin ... core-binding factor subunit alpha-1/Runt-related transcription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin ...

https://scholars.ncu.edu.tw/zh/publications/calcitriol-and-enamel-matrix-derivative-differentially-regulated-

... core gene set” will be a valuable resource from which to develop reference genes for gene expression studies. ... core gene set” of F. kawagutii. This improved genome will prove useful for future Symbiodiniaceae transcriptomic, gene ... homologous-pairing protein 2-like (HOP2) and meiosis protein 2 (MEI2), which function in mycosporine-like amino acids (MAAs) ... a binding proteins (PCP), a hypothetical protein (Ctob_001144), and the translation elongation factor 1 alpha-like protein. ...

https://www.mdpi.com/2076-2607/8/1/102/htm

CCAAT-Enhancer-Binding Protein-alpha. * Core Binding Factor Alpha 2 Subunit. * Female ...

https://profiles.uchicago.edu/profiles/display/222475

Core Binding Factor Alpha 2 Subunit/genetics , GTP Phosphohydrolases/genetics , Humans , Leukemia, Myeloid, Acute/genetics , ... were risk factors for DR. The level of serum CTRP9 was a risk factor affecting the occurrence of DME(OR=0.838, 95%CI: 0.778～ ... The risk factors of gastric cancer varied. There was a synergistic interaction effect between gender and refrigerator use years ... Risk factors of bronchopulmonary dysplasia in very preterm infants: a national multicenter study / 中国小儿急救医学 ...

https://pesquisa.bvsalud.org/gim/?lang=en&q=au:%22Yan%20ZHU%22

Core Binding Factor Alpha 2 Subunit. *COS Cells. *Cricetinae. *Culture Techniques. *Cyclin-Dependent Kinase Inhibitor p21 ...

https://profiles.ucdenver.edu/display/229262/network/researchareas/cloud

... a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 ... this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 ... alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase ... The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. The 26S proteasome is a multicatalytic ...

https://pharos.nih.gov/targets/PSMD2

Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are ... binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a ... This entry represents a structural domain with an alpha/beta-hammerhead fold, where the beta-hammerhead motif is similar to ... L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:Ribosomal_L16&START=5&END=150&E_VALUE=1.2e-20&TYPE=PFAM&BLAST=PARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRSTSQRSGASPSLMQMNLKTWLLRSGSFLMAVVSNISPIVV

Core Binding Factor Alpha 3 Subunit N0000169995 Core Binding Factor alpha Subunits N0000169994 Core Binding Factor beta Subunit ... N0000171389 Cord Factors N0000169996 Core Binding Factor Alpha 1 Subunit N0000169998 Core Binding Factor Alpha 2 Subunit ... Gi2 N0000170554 GTP-Binding Protein alpha Subunits N0000170556 GTP-Binding Protein alpha Subunits, G12-G13 N0000170558 GTP- ... Binding Protein alpha Subunits, Gi-Go N0000170557 GTP-Binding Protein alpha Subunits, Gq-G11 N0000170555 GTP-Binding Protein ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202007-10-09.txt

It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. (medlineplus.gov)
Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. (medlineplus.gov)
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). (embl.de)
Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. (embl.de)
The past few years have witnessed remarkable progress in knowledge of the structure and function of RNA-binding proteins and their RNA complexes. (embl-heidelberg.de)
X-ray crystallography and NMR spectroscopy have provided structures for all major classes of RNA-binding proteins, both alone and complexed with RNA. (embl-heidelberg.de)
RNA-binding strategies common to cold-shock domain- and RNA recognition motif-containing proteins. (embl-heidelberg.de)
Numerous RNA-binding proteins have modular structures, comprising one or several copies of a selective RNA-binding domain generally coupled to an auxiliary domain that binds RNA non-specifically. (embl-heidelberg.de)
SWIRM (Swi3p, Rsc8p, and Moira) domain is an alpha-helical domain of about 85 residues in chromosomal proteins. (hindawi.com)
SWIRM domain-containing proteins make up large multisubunit complexes by interacting with other chromatin modification factors and may have an important function in plants. (hindawi.com)
Generally, the SWIRM domain forms a helix-turn-helix motif commonly found in DNA-binding proteins. (hindawi.com)
We'll be at how subunits neurotransmitter grassroots identify tissues that proteins are. (evakoch.com)

Core binding factor (CBF), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus family of retroviruses. (nih.gov)

It contains a highly conserved DNA-binding domain known as the runt domain. (nih.gov)
The general subunit of all three eukaryotic RNA polymerases, Rpb12, and subunit P of the archaeal enzyme show sequence similarities in their N-terminal zinc ribbon and some highly conserved residues in the C-terminus. (cipsm.de)
Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). (cipsm.de)

One of the genes that encodes a CBF alpha subunit is AML1, also called Cbf alpha 2. (nih.gov)
HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (arigobio.cn)
Prediction of Core Cancer Genes Using Multitask Classification Framework. (nih.gov)
Regardless, many genes with distinct functions are co-regulated by the two transcription factors. (nature.com)

7. PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. (nih.gov)
15. Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. (nih.gov)

17. Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. (nih.gov)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. (nih.gov)

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. (nih.gov)
Factor de transcripción que dimeriza con el cofactor SUBUNIDAD BETA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL para formar el factor de unión al sitio principal. (bvsalud.org)

1. Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation. (nih.gov)
5. Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. (nih.gov)

These changes in chromatin involve activities of many chromatin-modifying complexes, consisting of both catalytic and noncatalytic subunits [ 5 ]. (hindawi.com)

RUNX3 is a member of the runt domain-containing family of transcription factors. (nih.gov)
It also interacts with other transcription factors. (nih.gov)
EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. (nature.com)

Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. (embl.de)
L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. (embl.de)

The transcription factor Runx1 is a pivotal regulator of definitive hematopoiesis in mouse ontogeny. (ox.ac.uk)

The core elements of the SL3 virus are important genetic determinants of the ability of this virus to induce T-cell lymphomas and the transcriptional activity of the viral long terminal repeat in T lymphocytes. (nih.gov)
The longest form, CBF beta-187, increased the transcriptional stimulation by CBF alpha 2-451 twofold in HeLa cells, although it had no effect in P19 cells. (nih.gov)
2. The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation. (nih.gov)
Vertebrate Runx1 is transcribed from 2 promoters, the distal P1 and proximal P2, which provide a paradigm of the complex transcriptional and translational control of Runx1 function. (ox.ac.uk)
Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)

18. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. (nih.gov)

The alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. (arigobio.cn)
Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (arigobio.cn)

The reversibly dynamic changes in chromatin structure modulate the access of regulatory factors to DNA [ 1 , 2 ]. (hindawi.com)
By generating two gene-modified mice facilitating chromatin immunoprecipitation of endogenous EOMES and T-BET, we show a strong overlap in their DNA binding targets, as well as extensive epigenetic changes during NK cell differentiation. (nature.com)

2023;13(2):255-270. (nih.gov)
2023 Feb;71(2):205-228. (nih.gov)
2023 Feb 2;24(3):2908. (nih.gov)

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin chain subunit vaccine antigen. (nih.gov)

ER-PM Junctions on GABAergic Interneurons Are Organized by Neuregulin 2/VAP Interactions and Regulated by NMDA Receptors. (nih.gov)
However, they differ from ILC1s by their capacity to circulate in the blood, by their expression of multiple receptors of the Ly49 family, by their higher cytotoxic potential and by their expression of integrin subunits. (nature.com)
These toxins bind to specific receptors of the intestinal epithelial cells and cause secretion of water and electrolytes into the intestinal lumen. (cdc.gov)

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. (nih.gov)

A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. (nih.gov)
It is related in sequence and structure to ACTIN and binds ATP. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Our results further show that the respective auxiliary domains, despite their lack of sequence homology, are functionally equivalent and indispensable for modulating the properties of the specific RNA-binding domains. (embl-heidelberg.de)
Based on the domain architectures and the amino acid sequence homology, the SWIRM domains can be classified into three main types: Swi3/MYSM1 (human MYb-like, Swirm, and Mpn domain-containing protein-1), LSD1 (Lysine-specific demethylase 1), and Ada2 (Adenosine deaminase isoenzymes 2) types [ 13 ]. (hindawi.com)
Ubiquitin roles are expressed from larger diseases and anywhere bound by dimethylglycine of a polyA protein complex between differentiation and a precursor Activation of an cytosolic caring sequence( UBA1 or UBA6, Jin et al. (evakoch.com)

Acute myeloid leukemia with runt-related transcription factor 1 gene mutation (RUNX1+ AML) is associated with inferior response rates and outcome after conventional chemotherapy. (tau.ac.il)

CBF consists of two subunits, a DNA binding subunit, CBF alpha, and a second subunit, CBF beta, that stimulates the DNA binding activity of CBF alpha. (nih.gov)
About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. (embl.de)

The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. (embl.de)

The protein produced from the normal RUNX1 gene is part of a protein complex known as core binding factor (CBF). (medlineplus.gov)
En las LEUCEMIAS humanas el Runx1 está mutado con frecuencia. (bvsalud.org)

2019-nCoV Vaccine mRNA-1273 mRNA vaccine against SARS-CoV-2 developed by Moderna. (nih.gov)
A viral vector vaccine designed against SARS-CoV-2 developed by Johnson & Johnson. (nih.gov)

11. Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. (nih.gov)
13. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. (nih.gov)

3. Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein. (nih.gov)
4. The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates. (nih.gov)
6. Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. (nih.gov)
2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. (nih.gov)
This entry represents a structural domain with an alpha/beta-hammerhead fold, where the beta-hammerhead motif is similar to that in barrel-sandwich hybrids. (embl.de)

8. The core binding factor (CBF) alpha interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFbeta-SMMHC are both required to slow cell proliferation. (nih.gov)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. (nih.gov)
Identification of an RNA-binding Site in the ATP binding domain of Escherichia coli Rho by H2O2/Fe-EDTA cleavage protection studies. (embl-heidelberg.de)
The Rho polypeptide has a distinct RNA binding domain of known structure as well as an ATP binding domain for which a structure has been proposed based on homology modeling. (embl-heidelberg.de)
The binding of ATP caused one distinct change in the cleavage pattern, a strong protection at a cleavage point in the P-loop of the ATP binding domain. (embl-heidelberg.de)
Binding of RNA and single-stranded DNA (poly(dC)) caused strong protection at several accessible parts of the oligosaccharide/oligonucleotide binding (OB) fold in the RNA binding domain. (embl-heidelberg.de)
RNA molecules but not DNA molecules also caused a strong, ATP-dependent protection at a cleavage site in the predicted Q-loop of the ATP binding domain. (embl-heidelberg.de)
Besides the site composed of multiples of the RNA binding domain, to which single-stranded DNA as well as RNA can bind, it has a separate, RNA-specific site on the Q-loop in the ATP binding domain. (embl-heidelberg.de)
and 3) near the proposed secondary RNA-binding site in the ATP-binding domain (Cys-325 Rho). (embl-heidelberg.de)

33(2): 320-323, 2022 Feb 17. (bvsalud.org)
AIM: To investigate the expression and correlation of C1q/tumor necrosis factor related protein 9(CTRP9)levels in the serum of patients with different stages of diabetic retinopathy(DR)and diabetic macular edema(DME).METHODS: A total of 135 patients with type 2 diabetes who were admitted to Gansu Provincial Hospital from April 2021 to April 2022 were selected as the experimental group. (bvsalud.org)

A membrane-bound membrane repair includes encoded by degradation of its potential design reviewed by processing of the C-terminus to a Co-Activator activity of the E1 complexes UBA1 or UBA6 via a survival full-length muscle( Jin et al. (evakoch.com)

By bringing together research institutions with large populations of patients with BE, we will perform a multi-center study of FISH and hypermethylation markers as possible prognostic factors in BE. (nih.gov)

Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. (embl.de)
Transcription factor Rho is a ring-shaped, homohexameric protein that causes transcript termination through actions on nascent RNAs that are coupled to ATP hydrolysis. (embl-heidelberg.de)
Escherichia coli transcription termination factor Rho is a ring-shaped hexameric protein that uses the energy derived from ATP hydrolysis to dissociate RNA transcripts from the ternary elongation complex. (embl-heidelberg.de)

The codons of the mRNA are exposed on the ribosome to allow tRNA binding. (embl.de)

9/3/2005) TOTAL DESCRIPTORS = 935 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
HN - 2006(1981) MH - 2-Aminoadipate Transaminase UI - D051307 MN - D8.811.913.477.700.120 MS - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-OXOGLUTARATE to generate 2-oxoadipate and L-GLUTAMATE. (nih.gov)
HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)
use AMINO ACIDS, BRANCHED-CHAIN 1979, & KETO ACIDS & VALERATES 1973-1979 MH - 3-Hydroxyanthranilate 3,4-Dioxygenase UI - D050561 MN - D8.811.682.690.416.328 MS - An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. (nih.gov)
use ANTHRANILIC ACID 1974-1979 MH - 3-Isopropylmalate Dehydrogenase UI - D050539 MN - D8.811.682.47.500 MS - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. (nih.gov)

16. Regulation mechanisms for the heterodimeric transcription factor, PEBP2/CBF. (nih.gov)

Such subunits are characterized by specific structural frames that mediate protein-protein and protein-DNA interactions. (hindawi.com)
The structural changes in activated CNFs were investigated using the following characterization techniques: N(2) adsorption isotherms at 77K, XRD, temperature-programmed desorption of hydrogen, TEM, TPO and elemental composition. (nih.gov)

In a mature phosphorylation muscle, largely 500 methylation of subunit is involved to myoglobin alleles organic( Russell 2003). (evakoch.com)

Indeed, even though all ILCs share a common progenitor, NK cells rapidly branch out from the main ILC developmental pathway 6 , and the factors that promote this route remain unclear. (nature.com)

Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
Our model of the CSD(FRG)-RNA complex constitutes the first prediction of the three-dimensional structure of a CSD-RNA complex and is consistent with the hypothesis of a convergent evolution of CSD and RRM towards a related single-stranded RNA-binding surface. (embl-heidelberg.de)
RNA passes through the hole of the protein hexamer in the complex with the Escherichia coli Rho factor. (embl-heidelberg.de)
By dying so we will initiate coordinate site about the mitotic ligands complex, and the rafts bound and activated will offer a different glutamine-N-acyltransferase of information for that glycoprotein. (evakoch.com)

Our data thus suggest that EOMES and T-BET may distinctly govern, via differential expression and co-factors recruitment, NK cell maturation by inserting partially overlapping epigenetic regulations. (nature.com)

Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale. (nih.gov)
NURBS: A Database of Experimental and Predicted Nuclear Receptor Binding Sites. (nih.gov)

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes. (nih.gov)

This glycoprotein is you left-right into how the alpha-ketoglutarate mouse number here is. (evakoch.com)

Gene Editing and Mouse Model Core Laboratory is either involved in generating mutant mice and/or helped in the study that warranted authorship or core acknowledgement in the published article. (nih.gov)

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)

Anatomy4

Diseases4

Chemicals and Drugs18

Phenomena and Processes14

Information Science3

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter. (1/859)

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. (2/859)

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. (3/859)

A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. (4/859)

Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1. (5/859)

Solution properties of the free and DNA-bound Runt domain of AML1. (6/859)

Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8. (7/859)

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation. (8/859)

Core Binding Factors

Core Binding Factor alpha Subunits

Core Binding Factor Alpha 1 Subunit

Core Binding Factor beta Subunit

Core Binding Factor Alpha 2 Subunit

Core Binding Factor Alpha 3 Subunit

Transcription Factor AP-2

Smooth Muscle Myosins

Transcription Factors

Chromosomes, Human, Pair 16

DNA-Binding Proteins

Chromosome Inversion

Leukemia, Myeloid, Acute

Molecular Sequence Data

Oncogene Proteins, Fusion

Base Sequence

Chromosomes, Human, Pair 21

Protein Binding

Neoplasm Proteins

Binding Sites

Osteoblasts

Enhancer Elements, Genetic

Translocation, Genetic

Osteogenesis

Osteocalcin

Mutation

Transforming Growth Factor alpha

Promoter Regions, Genetic

Tumor Necrosis Factor-alpha

Proto-Oncogene Proteins

Cell Line

Amino Acid Sequence

Cell Differentiation

Transcription, Genetic

Leukemia, Myeloid

Pol1 Transcription Initiation Complex Proteins

Alkaline Phosphatase

Three distinct domains in TEL-AML1 are required for transcriptional repression of the IL-3 promoter. (1/859)

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. (2/859)

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. (3/859)

A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. (4/859)

Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1. (5/859)

Solution properties of the free and DNA-bound Runt domain of AML1. (6/859)

Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8. (7/859)

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation. (8/859)

CBFA2T3

CBFA2T2

RUNX2

RUNX1

TAF11

CBFB

Sigma factor

STAT4

TBP-associated factor

GTF2A1L

CAAT box

SEC61B

TAF15

Sec61 alpha 1

Histone fold

EGLN1

RNA polymerase

PSMD10

POLR2J

EIF-W2 protein domain

PSMC5

Promoter (genetics)

Cyclin D

TAF9

CUL4A

General transcription factor

Bacterial transcription

SMARCC2

PPP2R1A

Tbf5 protein domain

PSMD7

Glucocorticoid receptor

PSMB3

DDB1

Chromosome 16