AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
Core Binding FactorsCore Binding Factor alpha SubunitsCore Binding Factor Alpha 1 SubunitCore Binding Factor beta SubunitCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitTranscription Factor AP-2Smooth Muscle MyosinsTranscription FactorsChromosomes, Human, Pair 16DNA-Binding ProteinsChromosome InversionLeukemia, Myeloid, AcuteMolecular Sequence DataOncogene Proteins, FusionBase SequenceChromosomes, Human, Pair 21Protein BindingNeoplasm ProteinsBinding SitesOsteoblastsEnhancer Elements, GeneticTranslocation, GeneticOsteogenesisOsteocalcinMutationTransforming Growth Factor alphaPromoter Regions, GeneticTumor Necrosis Factor-alphaProto-Oncogene ProteinsCell LineAmino Acid SequenceCell DifferentiationTranscription, GeneticLeukemia, MyeloidPol1 Transcription Initiation Complex ProteinsAlkaline Phosphatase
Core Binding Factors
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor alpha Subunits
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 1 Subunit
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
Core Binding Factor beta Subunit
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Core Binding Factor Alpha 2 Subunit
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
Core Binding Factor Alpha 3 Subunit
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.
Transcription Factor AP-2
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Smooth Muscle Myosins
Myosin type II isoforms found in smooth muscle.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Chromosomes, Human, Pair 16
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Chromosome Inversion
An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oncogene Proteins, Fusion
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Chromosomes, Human, Pair 21
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Osteoblasts
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
Enhancer Elements, Genetic
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Translocation, Genetic
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
Osteogenesis
The process of bone formation. Histogenesis of bone including ossification.
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Transforming Growth Factor alpha
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
Promoter Regions, Genetic
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cell Differentiation
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Transcription, Genetic
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Pol1 Transcription Initiation Complex Proteins
Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
Alkaline Phosphatase
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Cbfa1 isoforms exert functional differences in osteoblast differentiation. (1/863)

Cbfa1 is an essential transcription factor for osteoblast differentiation and bone formation. We investigated functional differences among three isoforms of Cbfa1: Type I (originally reported as Pebp2alphaA by Ogawa et al. (Ogawa, E., Maruyama, M., Kagoshima, H., Inuzuka, M., Lu, J., Satake, M., Shigesada, K., and Ito, Y. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6859-6863), Type II (originally reported as til-1 by Stewart et al. (Stewart, M., Terry, A., Hu, M., O'Hara, M., Blyth, K., Baxter, E., Cameron, E., Onions, D. E., and Neil, J. C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8646-8651), and Type III (originally reported as Osf2/Cbfa1 by Ducy et al. (Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997) Cell 89, 747-754). A reverse transcriptase-polymerase chain reaction analysis demonstrated that these isoforms were expressed in adult mouse bones. The transient transfection of Type I or Type II Cbfa1 in a mouse fibroblastic cell line, C3H10T1/2, induced the expression of alkaline phosphatase (ALP) activity. This induction was synergistically enhanced by the co-introduction of Xenopus BMP-4 cDNA. In contrast, the transient transfection of Type III cDNA induced no ALP activity. In C3H10T1/2 cells stably transfected with each isoform of Cbfa1, the gene expression of ALP was also strongly induced in cells transfected with Type I and Type II Cbfa1 but not in cells with Type III Cbfa1. Osteocalcin, osteopontin,and type I collagen gene expressions were induced or up-regulated in all of the cells stably transfected with each isoform of Cbfa1, and Type II transfected cells exhibited the highest expression level of osteocalcin gene. A luciferase reporter gene assay using a 6XOSE2-SV40 promoter (6 tandem binding elements for Cbfa1 ligated in front of the SV40 promoter sequence), a mouse osteocalcin promoter, and a mouse osteopontin promoter revealed the differences in the transcriptional induction of target genes by each Cbfa1 isoform with or without its beta-subunit. These results suggest that all three of the Cbfa1 isoforms used in the present study are involved in the stimulatory action of osteoblast differentiation, but they exert different functions in the process of osteoblast differentiation.  (+info)

Regulation of chondrocyte differentiation by Cbfa1. (2/863)

Cbfa1, a developmentally expressed transcription factor of the runt family, was recently shown to be essential for osteoblast differentiation. We have investigated the role of Cbfa1 in endochondral bone formation using Cbfa1-deficient mice. Histology and in situ hybridization with probes for indian hedgehog (Ihh), collagen type X and osteopontin performed at E13.5, E14.5 and E17.5 demonstrated a lack of hypertrophic chondrocytes in the anlagen of the humerus and the phalanges and a delayed onset of hypertrophy in radius/ulna in Cbfa1-/- mice. Detailed analysis of Cbfa1 expression using whole mount in situ hybridization and a lacZ reporter gene reveled strong expression not only in osteoblasts but also in pre-hypertrophic and hypertrophic chondrocytes. Our studies identify Cbfa1 as a major positive regulator of chondrocyte differentiation.  (+info)

Maturational disturbance of chondrocytes in Cbfa1-deficient mice. (3/863)

Cbfa1, a transcription factor that belongs to the runt-domain gene family, plays an essential role in osteogenesis. Cbfa1-deficient mice completely lacked both intramembranous and endochondral ossification, owing to the maturational arrest of osteoblasts, indicating that Cbfa1 has a fundamental role in osteoblast differentiation. However, Cbfa1 was also expressed in chondrocytes, and its expression was increased according to the maturation of chondrocytes. Terminal hypertrophic chondrocytes expressed Cbfa1 extensively. The significant expression of Cbfa1 in hypertrophic chondrocytes was first detected at embryonic day 13.5 (E13.5), and its expression in hypertrophic chondrocytes was most prominent at E14.5-16.5. In Cbfa1-deficient mice, whose entire skeleton was composed of cartilage, the chondrocyte differentiation was disturbed. Calcification of cartilage occurred in the restricted parts of skeletons, including tibia, fibula, radius, and ulna. Type X collagen, BMP6, and Indian hedgehog were expressed in their hypertrophic chondrocytes. However, osteopontin, bone sialoprotein, and collagenase 3 were not expressed at all, indicating that they are directly regulated by Cbfa1 in the terminal hypertrophic chondrocytes. Chondrocyte differentiation was severely disturbed in the rest of the skeleton. The expression of PTH/PTHrP receptor, Indian hedgehog, type X collagen, and BMP6 was not detected in humerus and femur, indicating that chondrocyte differentiation was blocked before prehypertrophic chondrocytes. These findings demonstrate that Cbfa1 is an important factor for chondrocyte differentiation.  (+info)

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. (4/863)

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally. The perinatal lethality occurring in Cbfa1-deficient mice has prevented so far the study of its function after birth. To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain (DeltaCbfa1) in differentiated osteoblasts only postnatally. DeltaCbfa1 has a higher affinity for DNA than Cbfa1 itself, has no transcriptional activity on its own, and can act in a dominant-negative manner in DNA cotransfection assays. DeltaCbfa1-expressing mice have a normal skeleton at birth but develop an osteopenic phenotype thereafter. Dynamic histomorphometric studies show that this phenotype is caused by a major decrease in the bone formation rate in the face of a normal number of osteoblasts thus indicating that once osteoblasts are differentiated Cbfa1 regulates their function. Molecular analyses reveal that the expression of the genes expressed in osteoblasts and encoding bone ECM proteins is nearly abolished in transgenic mice, and ex vivo assays demonstrated that DeltaCbfa1-expressing osteoblasts were less active than wild-type osteoblasts. We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. This study demonstrates that beyond its differentiation function Cbfa1 is the first transcriptional activator of bone formation identified to date and illustrates that developmentally important genes control physiological processes postnatally.  (+info)

Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. (5/863)

Collagenase 3 (MMP-13) is a recently identified member of the matrix metalloproteinase (MMP) gene family that is expressed at high levels in diverse human carcinomas and in articular cartilage from arthritic patients. In addition to its expression in pathological conditions, collagenase 3 has been detected in osteoblasts and hypertrophic chondrocytes during fetal ossification. In this work, we have evaluated the possibility that Cbfa1 (core binding factor 1), a transcription factor playing a major role in the expression of osteoblastic specific genes, is involved in the expression of collagenase 3 during bone formation. We have functionally characterized a Cbfa motif present in the promoter region of collagenase 3 gene and demonstrated, by cotransfection experiments and gel mobility shift assays, that this element is involved in the inducibility of the collagenase 3 promoter by Cbfa1 in osteoblastic and chondrocytic cells. Furthermore, overexpression of Cbfa1 in osteoblastic cells unable to produce collagenase 3 leads to the expression of this gene after stimulation with transforming growth factor beta. Finally, we show that mutant mice deficient in Cbfa1, lacking mature osteoblasts but containing hypertrophic chondrocytes which are also a major source of collagenase 3, do not express this protease during fetal development. These results provide in vivo evidence that collagenase 3 is a target of the transcriptional activator Cbfa1 in these cells. On the basis of these transcriptional regulation studies, together with the potent proteolytic activity of collagenase 3 on diverse collagenous and noncollagenous bone and cartilage components, we proposed that this enzyme may play a key role in the process of bone formation and remodeling.  (+info)

Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. (6/863)

Osteoblasts and odontoblasts, cells that are responsible for the formation of bone and dentin matrices respectively, share several molecular characteristics. Recently, Cbfa1 was shown to be a critical transcriptional regulator of osteoblast differentiation. Mutations in this gene cause cleidocranial dysplasia (CCD), an autosomal dominant disorder in humans and mice characterized by defective bone formation. CCD also results in dental defects that include supernumerary teeth and delayed eruption of permanent dentition. The dental abnormalities in CCD suggest an important role for this molecule in the formation of dentition. Here we describe results of studies aimed at understanding the functions of Cbfa1 in tooth formation. RT-PCR and in situ hybridization analyses show that Cbfa1 has a unique expression pattern in dental mesenchyme from the bud to early bell stages during active epithelial morphogenesis. Unlike that observed in osteoblast differentiation, Cbfa1 is downregulated in fully differentiated odontoblasts and is surprisingly expressed in ectodermally derived ameloblasts during the maturation phase of enamel formation. The role of Cbfa1 in tooth morphogenesis is further illustrated by the misshapen and severely hypoplastic tooth organs in Cbfa1-/- mice. These tooth organs lacked overt odontoblast and ameloblast differentiation and normal dentin and enamel matrices. Epithelial-mesenchymal recombinants demonstrate that dental epithelium regulates mesenchymal Cbfa1 expression during the bud and cap stages and that these effects are mimicked by the FGFs but not by the BMPs as shown by our bead implantation assays. We propose that Cbfa1 regulates the expression of molecules in mesenchyme that act reciprocally on dental epithelium to control its growth and differentiation. Taken together, our data indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ.  (+info)

Dexamethasone enhances In vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells. (7/863)

Vascular calcification is often associated with atherosclerotic lesions. Moreover, the process of atherosclerotic calcification has several features similar to the mineralization of skeletal tissue. Therefore, we hypothesized that vascular smooth muscle cells might acquire osteoblastic characteristics during the development of atherosclerotic lesions. In the present study, we investigated the effect of dexamethasone (Dex), which is well known to be a potent stimulator of osteoblastic differentiation in vitro, on vascular calcification by using an in vitro calcification model. We demonstrated that Dex increased bovine vascular smooth muscle cell (BVSMC) calcification in a dose- and time-dependent manner. Dex also enhanced several phenotypic markers of osteoblasts, such as alkaline phosphatase activity, procollagen type I carboxy-terminal peptide production, and cAMP responses to parathyroid hormone in BVSMCs. We also examined the effects of Dex on human osteoblast-like (Saos-2) cells and compared its effects on BVSMCs and Saos-2 cells. The effects of Dex on alkaline phosphatase activity and the cAMP response to parathyroid hormone in BVSMCs were less prominent than those in Saos-2 cells. Interestingly, we detected that Osf2/Cbfa1, a key transcription factor in osteoblastic differentiation, was expressed in both BVSMCs and Saos-2 cells and that Dex increased the gene expression of both transcription factors. These findings suggest that Dex may enhance osteoblastic differentiation of BVSMCs in vitro.  (+info)

Does adult fracture repair recapitulate embryonic skeletal formation? (8/863)

Bone formation is a continuous process that begins during fetal development and persists throughout life as a remodeling process. In the event of injury, bones heal by generating new bone rather than scar tissue; thus, it can accurately be described as a regenerative process. To elucidate the extent to which fetal skeletal development and skeletal regeneration are similar, we performed a series of detailed expression analyses using a number of genes that regulate key stages of endochondral ossification. They included genes in the indian hedgehog (ihh) and core binding factor 1 (cbfa1) pathways, and genes associated with extracellular matrix remodeling and vascular invasion including vascular endothelial growth factor (VEGF) and matrix metalloproteinase 13 (mmp13). Our analyses suggested that even at the earliest stages of mesenchymal cell condensation, chondrocyte (ihh, cbfa1 and collagen type II-positive) and perichondrial (gli1 and osteocalcin-positive) cell populations were already specified. As chondrocytes matured, they continued to express cbfa1 and ihh whereas cbfa1, osteocalcin and gli1 persisted in presumptive periosteal cells. Later, VEGF and mmp13 transcripts were abundant in chondrocytes as they underwent hypertrophy and terminal differentiation. Based on these expression patterns and available genetic data, we propose a model where Ihh and Cbfa1, together with Gli1 and Osteocalcin participate in establishing reciprocal signal site of injury. The persistence of cbfa1 and ihh, and their targets osteocalcin and gli1, in the callus suggests comparable processes of chondrocyte maturation and specification of a neo-perichondrium occur following injury. VEGF and mmp13 are expressed during the later stages of healing, coincident with the onset of vascularization of the callus and subsequent ossification. Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration.  (+info)

Bone-specific transcription factor Runx2 interacts with the 1α,25-dihydroxyvitamin D<sub>3</sub> receptor to up-regulate rat...
TY - JOUR. T1 - Bone-specific transcription factor Runx2 interacts with the 1α,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. AU - Paredes, Roberto. AU - Arriagada, Gloria. AU - Cruzat, Fernando. AU - Villagra, Alejandro. AU - Olate, Juan. AU - Zaidi, Kaleem. AU - Van Wijnen, Andre. AU - Lian, Jane B.. AU - Stein, Gary S.. AU - Stein, Janet L.. AU - Montecino, Martin. PY - 2004/10. Y1 - 2004/10. N2 - Bone-specific transcription of the osteocalcin (OC) gene is regulated principally by the Runx2 transcription factor and is further stimulated in response to 1α,25-dihydroxyvitamin D3 via its specific receptor (VDR). The rat OC gene promoter contains three recognition sites for Runx2 (sites A, B, and C). Mutation of sites A and B, which flank the 1α,25-dihydroxyvitamin D3-responsive element (VDRE), abolishes 1α,25-dihydroxyvitamin D3-dependent enhancement of OC transcription, indicating a tight functional relationship between the VDR and ...
https://mayoclinic.pure.elsevier.com/en/publications/bone-specific-transcription-factor-runx2-interacts-with-the-1%CE%B125-
Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer<...
TY - JOUR. T1 - Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer. AU - Horiguchi, Shigeru. AU - Shiraha, Hidenori. AU - Nagahara, Teruya. AU - Kataoka, Jyunnro. AU - Iwamuro, Masaya. AU - Matsubara, Minoru. AU - Nishina, Shinichi. AU - Kato, Hironari. AU - Takaki, Akinobu. AU - Nouso, Kazuhiro. AU - Tanaka, Takehiro. AU - Ichimura, Koichi. AU - Yagi, Takahito. AU - Yamamoto, Kazuhide. PY - 2013/8. Y1 - 2013/8. N2 - Background & Aim: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor gene that is expressed in gastric and other cancers including pancreatic cancer. However, the precise function of RUNX3 in pancreatic cancer has not been fully elucidated. In this study, we aimed to determine the effect of decreased RUNX3 expression in pancreatic cancer. Methods: This study included 36 patients with primary pancreatic cancer, who had undergone pancreaticoduodenectomy. All patients were treated with 1000mg/m2 gemcitabine after the surgery. ...
https://okayama.pure.elsevier.com/en/publications/loss-of-runt-related-transcription-factor-3-induces-gemcitabine-r
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo | Journal of...
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the regulatory mechanisms underlying RUNX1 expression in neuroblastoma (NB), a highly malignant tumor in childhood, remain largely unclear. In this study, we aimed to assess the role of RUNX1 in NB and to reveal the underlying mechanisms that may contribute to finding a potential therapeutics strategy against NB. Growth, invasion, metastasis and angiogenesis were assessed using Cell Counting Kit-8 (CCK-8) immunocytochemistry, and studies involving soft agar, cell invasion, tube formation and whole animals. The levels of expression were measured using real-time quantitative PCR for RNA, Western blot and immunostaining analyses for proteins. Luciferase reporter and chromatin immunoprecipitation assays indicated that RUNX1 directly binds within the BIRC5, CSF2RB and NFKBIA promoter regions to facilitate
https://jeccr.biomedcentral.com/articles/10.1186/s13046-020-01558-2
Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048
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Paper: Emdogain®: Analysis of Bioactive Chemical Mediators involved in Periodontal Regeneration (AADR Annual Meeting (March 21...
Objective: To evaluate the kinetics of bone formation of Pool 7 EMD, by concentration, on the amount of marrow formation and study factors relating to angiogenesis associated with EMD-induced bone formation. Methods: Fractionated commercial Emdogain® (EMD) was obtained from Straumann International. 60 CDI 7 day old outbred mice were injected using 50 μl aliquots of 10 µg EMD, 10 µg Pool 7 EMD, 2 µg TGF-β (positive control) or phosphate buffered saline (PBS, negative control) delivered in a calvarial injection model. Injections were done for 5 consecutive days. The animals were sacrificed on days 6, 8, 12, 16 and 21 with 6 animals per factor for each time point and were prepared for histological evaluation. Nikon NIS Elements software was used to analyze vascular growth and new bone formation over the five time intervals at 20x magnification. Immunocytochemistry (IHC) was used to identify the kinetics of osteogenesis by evaluating the osteoblast transcription factor Osterix, and the ...
http://www-personal.umich.edu/~sbayne/DMG/DMG-Publications/IADR-AADR-Meeting-Program-Books/2012-AADR-Tampa/2012-AADR-Tampa-CD/AADR12/Paper157683.html
O-GlcNAc Modification of the runt-Related Transcription Factor 2 (Runx2) Links Osteogenesis and Nutrient Metabolism in Bone...O-GlcNAc Modification of the runt-Related Transcription Factor 2 (Runx2) Links Osteogenesis and Nutrient Metabolism in Bone...
As a forum for professional feedback, submissions of letters are open to all. You do not need to be a subscriber. To avoid redundancy, we urge you to read other peoples letters before submitting your own. Name, current appointment, place of work, and email address are required to send a letter, and will be published with your review. We also require that you declare any competing financial interests. Unprofessional submissions will not be considered or responded to.. ...
https://www.mcponline.org/content/13/12/3381/tab-e-letters
WikiGenes - RUNX1 - runt-related transcription factor 1WikiGenes - RUNX1 - runt-related transcription factor 1
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https://www.wikigenes.org/e/gene/e/101058316.html
Most recent papers with the keyword Vdr | Read by QxMDMost recent papers with the keyword Vdr | Read by QxMD
Our previous reports indicated that (+)-cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) by activating vitamin D receptor (VDR). However, whether and how miRNAs modulate osteogenic differentiation induced by (+)-cholesten-3-one have not been explored. In this study, miRNA array profiling and further validation by quantitative real-time PCR revealed that miR-351 was downregulated during (+)-cholesten-3-one-induced osteogenic differentiation of MSCs. Overexpression of miR-351 by miR-351 precursor transfection markedly inhibited the expression of osteoblast-specific genes, such as alkaline phosphatase (ALP), collagen type II, osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), which consequently decreased a number of calcium mineralized nodules ...
https://www.readbyqxmd.com/keyword/6301
Publications - Mayo ClinicPublications - Mayo Clinic
van der Deen M, Taipaleenmaki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. J Biol Chem. 2013 Jul 19; 288(29):21307-19. Epub 2013 May 29 ...
http://www.mayo.edu/research/searchpublications/publications?authid=12834807
Runx1 gene cDNA ORF clone, Rattus norvegicus(Norway rat) - GenScriptRunx1 gene cDNA ORF clone, Rattus norvegicus(Norway rat) - GenScript
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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17...Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/18849990?dopt=Abstract
anti-RUNX1 antibody | GeneTexanti-RUNX1 antibody | GeneTex
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http://www.genetex.com/RUNX1-antibody-GTX129100.html
Amgen Exercises Option for Exclusive License to Cytokinetics Cardiac Contractility Program That Includes CK-1827452 |...
SOUTH SAN FRANCISCO, CA and THOUSAND OAKS, CA, May 26, 2009 (MARKET WIRE via COMTEX) -- Cytokinetics Incorporated (NASDAQ: CYTK) and Amgen Inc. (NASDAQ: AMGN) today announced that Amgen has exercised its option to obtain an exclusive license, worldwide (excluding Japan), to Cytokinetics cardiac contractility program. The license includes CK-1827452, a novel cardiac myosin activator being developed for the treatment of heart failure. Under the terms of the companies 2006 collaboration and option agreement, Amgen has agreed to pay Cytokinetics a non-refundable exercise fee of $50 million and has assumed responsibility for development and commercialization of CK-1827452 and related compounds, at its expense, subject to specified development and commercial participation rights of Cytokinetics. After reviewing the data from the CK-1827452 clinical trials, we are excited about the opportunity to advance this molecule, said Amgen Executive Vice President for Research and Development, Roger M. ...
http://ir.cytokinetics.com/news-releases/news-release-details/amgen-exercises-option-exclusive-license-cytokinetics-cardiac
Myocyte Enhancer Factor 2c, an Osteoblast Transcription FactorMyocyte Enhancer Factor 2c, an Osteoblast Transcription Factor
The Author(s) 2014. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this conference please refer to the conferences website or contact the authors ...
https://research-repository.griffith.edu.au/handle/10072/65730
Mutations in the RUNX2 gene in patients with cleidocranial dysplasia :: MPG.PuReMutations in the RUNX2 gene in patients with cleidocranial dysplasia :: MPG.PuRe
Autor: Otto, Florian et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2002-02-13; Keywords: cleidocranial dysplasia; CCD; transcription factor; core binding factor; runt domain; RUNX2; CBFA1; differentiation; osteoblast; Titel: Mutations in the RUNX2 gene in patients with cleidocranial dysplasia
http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1586409
Identification of RUNX2 variants associated with cleidocranial dysplasia | Hereditas | Full TextIdentification of RUNX2 variants associated with cleidocranial dysplasia | Hereditas | Full Text
Cleidocranial dysplasia (CCD) is a rare autosomal dominant disorder mainly characterized by hypoplastic or absent clavicles, delayed closure of the fontanelles, multiple dental abnormalities, and short stature. Runt-related transcription factor 2 (RUNX2) gene variants can cause CCD, but are not identified in all CCD patients. In this study, we detected genetic variants in seven unrelated children with CCD by targeted high-throughput DNA sequencing or Sanger sequencing. All patients carried a RUNX2 variant, totally including three novel pathogenic variants (c.722_725delTGTT, p.Leu241Serfs*8; c.231_232delTG, Ala78Glyfs*82; c.909C | G, p.Tyr303*), three reported pathogenic variants (c.577C | T, p.Arg193*; c.574G | A, p.Gly192Arg; c.673 C | T, p.Arg225Trp), one likely pathogenic variant (c.668G | T, p.Gly223Val). The analysis of the variant source showed that all variants were de novo except the two variants (c.909C | G, p.Tyr303*; c.668G | T, p.Gly223Val) inherited from the patients father and mother with
https://hereditasjournal.biomedcentral.com/articles/10.1186/s41065-019-0107-7/tables/4
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis...The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis...
The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylation but also at distal elements characterized by low acetylation levels and binding of the hematopoietic transcription factors LYL1 and LMO2. In contrast, ERG, FLI1, TAL1, and RUNX1 bind at all AML1-ETO-occupied regulatory regions, including those of the AML1-ETO gene itself, suggesting their involvement in regulating AML1-ETO expression levels. While expression of AML1-ETO in myeloid differentiated induced pluripotent stem cells (iPSCs) induces leukemic characteristics, overexpression increases cell death. We find that expression of wild-type transcription factors RUNX1 and ERG in AML is required to prevent this oncogene overexpression. Together our results show that the interplay ...
https://library.wur.nl/WebQuery/wurpubs/560840
Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo | Garvan...Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo | Garvan...
BACKGROUND: Aberrant expression of the transcription factor RUNX2 in prostate cancer has a number of important consequences including increased resistance to apoptosis, invasion and metastasis to bone. We previously demonstrated that hypoxia up-regulated RUNX2 in tumour cells, which in turn up-regulated the anti-apoptotic factor Bcl-2. Here, we investigate the impact of nitric oxide (NO) on RUNX2 and Bcl-2 expression in prostate cancer and further, how RUNX2 over-expression can impact tumour growth, angiogenesis and oxygenation in vivo. METHODS: The effect of NO levels on RUNX2 and thus Bcl-2 expression was examined in prostate cancer cells in vitro using methods including gene and protein expression analyses, nitrite quantitation, protein-DNA interaction assays (ChIP) and viability assays (XTT). The effect of RUNX2 over-expression on tumour physiology (growth, oxygenation and angiogenesis) was also assessed in vivo using LNCaP xenografts. RESULTS: A low (but not high) concentration of NO (10microM)
https://www.garvan.org.au/research/publications/13244
Loss of Runx2 in Committed Osteoblasts Impairs Postnatal Skeletogenesis - BIOQUANT OSTEOLoss of Runx2 in Committed Osteoblasts Impairs Postnatal Skeletogenesis - BIOQUANT OSTEO
The Runx2 transcription factor is critical for commitment to the osteoblast lineage. However, its role in committed osteoblasts and its functions during postnatal skeletogenesis remain unclear. We established a Runx2-floxed line with insertion of loxP sites around exon 8 of the Runx2 gene. Runx2 protein lacking the region encoded by exon 8 is imported into the nucleus and binds target DNA, but exhibits diminished transcriptional activity. We specifically deleted the Runx2 gene in committed osteoblasts using 2.3kb col1a-Cre transgenic mice. Surprisingly, the homozygous Runx2 mutant mice were born alive. The Runx2 heterozygous and homozygous null were grossly indistinguishable from wild-type littermates at birth. Runx2 deficiency did not alter proliferative capacity of osteoblasts during embryonic development (E18). Chondrocyte differentiation and cartilage growth in mutants was similar to wild-type mice from birth to 3 months of age. Analysis of the embryonic skeleton revealed poor calcification ...
https://osteo.bioquant.com/bibliography-entries/2016/4/7/loss-of-runx2-in-committed-osteoblasts-impairs-postnatal-skeletogenesis
서울대학교의과대학서울대학교의과대학
PHF2라는 단백질이 뼈를 만드는 세포(조골세포)를 활성화시킨다는 사실을 처음으로 규명했다. 조골세포는 Runx2라는 단백질에 의해 분화가 조절된다. 반면, SUV39HI1라는 효소는 Runx2에 메틸기(CH3)를 붙임으로써 Runx2가 기능을 하지 못하게 하는 장식으로 분화를 방해한다. 성장이 끝난 성인들이 더 이상 키가 크지 않는 것도 SUV39HI1 효소 때문이다. 이에 착안해 Runx2에 붙어 있는 메틸기를 제거하는 방안을 연구한 결과, PHF2 단백질이 조골세포 분화를 유도함으로써, 소아의 뼈 발달 과정이나 골절 후 뼈가 새로 형성되는 과정에 작용한다는 것을 증명했다.. PHF2 단백질은 Runx2에 붙어 있는 메틸기를 제거했으며, 이후 본연의 기능을 회복한 Runx2는 조골세포의 분화를 촉진하여 다시 뼈를 만들기 시작했다. 실제 유전자 조작으로 PHF2 단백질이 과발현된 쥐를 만들어 ...
http://medicine.snu.ac.kr/sub4/result/result/read.htm?bn=result&fmlid=0&pkid=92&board_no=3832&thisPage=1&startTextId=&buffer=
Bulova Mens Quartz Blue Dial Rotating Bezel Calendar Date 44mm Watch 98A194 - MellonPostBulova Mens Quartz Blue Dial Rotating Bezel Calendar Date 44mm Watch 98A194 - MellonPost
The item has been restored to working order by the eBay seller or a third party. This means the item was inspected, cleaned, and repaired to full working order and is in excellent condition. This item may or may not be in original packaging. See sellers listing for full details ...
https://mellonpost.com/bulova-mens-quartz-blue-dial-rotating-bezel-calendar-date-44mm-watch-98a194/
core binding factor alpha Summary Report | CureHuntercore binding factor alpha Summary Report | CureHunter
core binding factor alpha: core binding factor plays a key role in several development pathways and in human disease; has been sequenced
http://www.curehunter.com/public/keywordSummaryC406688-core-binding-factor-alpha.do
Heparin-binding EGF-like growth factor and miR-1192 exert opposite effect on Runx2-induced osteogenic differentiation -...Heparin-binding EGF-like growth factor and miR-1192 exert opposite effect on Runx2-induced osteogenic differentiation -...
Osteoblast differentiation is a pivotal event in bone formation. Runt-related transcription factor-2 (Runx2) is an essential factor required for osteoblast differentiation and bone formation. However, the underlying mechanism of Runx2-regulated osteogenic differentiation is still unclear. Here, we explored the corresponding mechanism using the C2C12/Runx2Dox subline, which expresses Runx2 in response to doxycycline (Dox). We found that Runx2-induced osteogenic differentiation of C2C12 cells results in a sustained decrease in the expression of heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family. Forced expression of HB-EGF or treatment with HB-EGF is capable of reducing the expression of alkaline phosphatase (ALP), a defined marker of early osteoblast differentiation. HB-EGF-mediated inhibition of ALP depends upon activation of the EGFR and the downstream extracellular signal-regulated kinase, c-Jun N-terminal kinase mitogen-activated protein kinase
https://www.semanticscholar.org/paper/Heparin-binding-EGF-like-growth-factor-and-miR-119-Yu-Geng/672d6ddbe280b422dff2e291a739e4c7a03e59d9
DMOZ - Health: Conditions and Diseases: Musculoskeletal Disorders: Cleidocranial Dysplasia
Cleidocranial dysplasia (CCD) is an autosomal dominant skeletal dysplasia. Affected individuals have hypoplastic/aplastic clavicles and multiple dental abnormalities.
http://dmoztools.net/Health/Conditions_and_Diseases/Musculoskeletal_Disorders/Cleidocranial_Dysplasia/
Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways |...Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways |...
Osteoporosis results from the imbalance between bone resorption and bone formation, and restoring the normal balance of bone remodeling is highly desirable for identification of better treatment. In this study, using a cell-based high-throughput screening model representing Runt-related transcription factor 2 (RUNX2) transcriptional activity, we identified a novel small-molecular-weight compound, T63, as an efficient up-regulator of osteogenesis. T63 increased the alkaline phosphatase (ALPL) activity and mineralization as well as gene expression of Alpl and other osteogenic marker genes in mouse osteoblasts and mesenchymal stem cell-like cells. Upon induction of osteoblast differentiation, T63 inhibited adipogenic differentiation in the pluripotent mesenchymal cells. Consistently, T63 up-regulated RUNX2 mRNA and protein levels, and knockdown of RUNX2 reduced the osteogenic role of T63. Mechanistically, T63 activated both BMPs and WNT/β-catenin signaling pathways. Inhibition of either signaling pathway
https://www.nature.com/articles/s41598-017-10929-3?error=cookies_not_supported&code=55fb5181-06a5-444f-b2da-42f27a14f007
Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or...Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or...
Runt-related transcription factor 1 (Runx1), a master regulator of hematopoiesis, is expressed in preosteoclasts. Previously we evaluated the bone phenotype of CD11b-Cre Runx1(fl/fl) mice and demonstrated enhanced osteoclasts and decreased bone mass in males. However, an assessment of the effects of Runx1 deletion in female osteoclast precursors was impossible with this model. Moreover, the role of Runx1 in myeloid cell differentiation into other lineages is unknown. Therefore, we generated LysM-Cre Runx1(fl/fl) mice, which delete Runx1 equally (∼80% deletion) in myeloid precursor cells from both sexes and examined the capacity of these cells to differentiate into osteoclasts and phagocytic and antigen-presenting cells. Both female and male LysM-Cre Runx1(fl/fl) mice had decreased trabecular bone mass (72% decrease in bone volume fraction) and increased osteoclast number (2-3 times) (P < .05) without alteration of osteoblast histomorphometric indices. We also demonstrated that loss of Runx1 in ...
https://www.pubfacts.com/detail/27267711/Runx1-Regulates-Myeloid-Precursor-Differentiation-Into-Osteoclasts-Without-Affecting-Differentiation
Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription<...
TY - JOUR. T1 - Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. AU - Zaidi, Sayyed K.. AU - Sullivan, Andrew J.. AU - Medina, Ricardo. AU - Ito, Yoshiaki. AU - van Wijnen, Andre J. AU - Stein, Janet L.. AU - Lian, Jane B.. AU - Stein, Gary S.. PY - 2004/2/25. Y1 - 2004/2/25. N2 - Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and inhibits osteoblast activity. Here we show that the endogenous Yes-associated protein (YAP), a mediator of Src/Yes signaling, interacts with the native Runx2 protein, an osteoblast-related transcription factor, and suppresses Runx2 transcriptional activity in a dose-dependent manner. Runx2, through its PY motif, recruits YAP to subnuclear domains in situ and to the osteocalcin (OC) gene promoter in vivo. Inhibition of Src/Yes kinase blocks tyrosine phosphorylation of YAP and dissociates endogenous Runx2-YAP complexes. Consequently, recruitment of the YAP co-repressor to ...
https://mayoclinic.pure.elsevier.com/en/publications/tyrosine-phosphorylation-controls-runx2-mediated-subnuclear-targe
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation - ePrints -...The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation - ePrints -...
2018 The Author(s) Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which drives t(8;21) acute myeloid leukemia (AML), constitute cancer-specific but highly challenging therapeutic targets. We used epigenomic profiling data for an RNAi screen to interrogate the transcriptional network maintaining t(8;21) AML. This strategy identified Cyclin D2 (CCND2) as a crucial transmitter of RUNX1/ETO-driven leukemic propagation. RUNX1/ETO cooperates with AP-1 to drive CCND2 expression. Knockdown or pharmacological inhibition of CCND2 by an approved drug significantly impairs leukemic expansion of patient-derived AML cells and engraftment in immunodeficient murine hosts. Our data demonstrate that RUNX1/ETO maintains leukemia by promoting cell cycle progression and identifies G1 CCND-CDK complexes as promising therapeutic targets for treatment of RUNX1/ETO-driven AML. Using in vitro and in vivo screens to identify essential RUNX1/ETO transcriptional targets in AML, Martinez-Soria ...
https://eprint.ncl.ac.uk/251837
JCI - Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesisJCI - Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis
The molecular mechanisms that transduce the osteoblast response to physical forces in the bone microenvironment are poorly understood. Here, we used genetic and pharmacological experiments to determine whether the polycystins PC1 and PC2 (encoded by Pkd1 and Pkd2) and the transcriptional coactivator TAZ form a mechanosensing complex in osteoblasts. Compound-heterozygous mice lacking 1 copy of Pkd1 and Taz exhibited additive decrements in bone mass, impaired osteoblast-mediated bone formation, and enhanced bone marrow fat accumulation. Bone marrow stromal cells and osteoblasts derived from these mice showed impaired osteoblastogenesis and enhanced adipogenesis. Increased extracellular matrix stiffness and application of mechanical stretch to multipotent mesenchymal cells stimulated the nuclear translocation of the PC1 C-terminal tail/TAZ (PC1-CTT/TAZ) complex, leading to increased runt-related transcription factor 2-mediated (Runx2-mediated) osteogenic and decreased PPARγ-dependent adipogenic ...
https://www.jci.org/articles/view/93725/figure/1
Funny Gene Names - Not To Be Trusted With Knives
Sometimes, a lot of people discover the same protein and so it gets a lot of names, like Runt-related transcription factor 2 (Runx2), which is also known as: Cbfa1, Osf2, AML3, Til1, and Pebp2 αA or PPB2αA… talk about having an identity crisis!. After writing my list, I Googled funny gene names to see what other funny names are out their and discovered on this site that there are waaaaaaay better gene names that Ive never heard of before (probably the best on this list are cheap date, lunatic fringe, grim and reaper (which work together to control cell death), and INDY, which makes mutant fruit flies live twice as long… its an acronym for Im not dead yet (from Monty Python and the Holy Grail).. ...
https://www.nottobetrustedwithknives.com/2005/09/01/funny-gene-names/
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal...Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
https://gut.bmj.com/content/69/4/630.info
Loss of RUNX1/ETO Triggers C/EBPα-Driven Reorganizatio | Open-iLoss of RUNX1/ETO Triggers C/EBPα-Driven Reorganizatio | Open-i
Loss of RUNX1/ETO Triggers C/EBPα-Driven Reorganization of the Leukemic Transcriptional Network(A) RUNX1/ETO and CEBPA mRNA expression levels in Kasumi-1 cells
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4487811_nihms703543f7&req=4
IRESite Id:57 summary record describing characteristics of AML1/RUNX1 IRESIRESite Id:57 summary record describing characteristics of AML1/RUNX1 IRES
CATAGAGCCA GCGGGCGCGG GCGGGACGGG CGCCCCGCGG CCGGACCCAG CCAGGGCACC ACGCTGCCCG GCCCTGCGCC GCCAGGCACT TCTTTCCGGG ^1 ^11 ^21 ^31 ^41 ^51 ^61 ^71 ^81 ^91 GCTCCTAGGG ACGCCAGAAG GAAGTCAACC TCTGCTGCTT CTCCTTGGCC TGCGTTGGAC CTTCCTTTTT TTGTTGTTTT TTTTTGTTTT TCCCCTTTCT ^101 ^111 ^121 ^131 ^141 ^151 ^161 ^171 ^181 ^191 TCCTTTTGAA TTAACTGGCT TCTTGGCTGG ATGTTTTCAA CTTCTTTCCT GGCTGCGAAC TTTTCCCCAA TTGTTTTCCT TTTACAACAG GGGGAGAAAG ^201 ^211 ^221 ^231 ^241 ^251 ^261 ^271 ^281 ^291 TGCTCTGTGG TCCGAGGCGA GCCGTGAAGT TGCGTGTGCG TGGCAGTGTG CGTGGCAGGA TGTGCGTGCG TGTGTAACCC GAGCCGCCCG ATCTGTTTCG ^301 ^311 ^321 ^331 ^341 ^351 ^361 ^371 ^381 ^391 ATCTGCGCCG CGGAGCCCTC CCTCAAGGCC CGCTCCACCT GCTGCGGTTA CGCGGCGCTC GTGGGTGTTC GTGCCTCGGA GCAGCTAACC GGCGGGTGCT ^401 ^411 ^421 ^431 ^441 ^451 ^461 ^471 ^481 ^491 GGGCGACGGT GGAGGAGTAT CGTCTCGCTG CTGCCCGAGT CAGGGCTGAG TCACCCAGCT GATGTAGACA GTGGCTGCCT TCCGAAGAGT GCGTGTTTGC ^501 ^511 ^521 ^531 ^541 ^551 ^561 ^571 ^581 ^591 ATGTGTGTGA CTCTGCGGCT GCTCAACTCC CAACAAACCA GAGGACCAGC ...
http://www.iresite.org/IRESite_web.php?page=view&entry_id=57
Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels<...
TY - JOUR. T1 - Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. AU - Moe, Sharon. AU - Duan, Danxia. AU - Doehle, Brian P.. AU - ONeill, Kalisha D.. AU - Chen, Xuening (Neal). PY - 2003/3/1. Y1 - 2003/3/1. N2 - Background. Bone matrix proteins are expressed in calcified arteries from dialysis patients, suggesting that vascular smooth muscle cells (VSMCs) may transform to osteoblast-like cells. One of the key transcriptional regulators of osteoblast differentiation is Cbfa1. Thus, we hypothesized that this may be a key factor in arterial calcification. Methods. To test this hypothesis, we examined sections of the inferior epigastric artery from uremic patients for the presence of Cbfa1 and type I collagen and osteopontin by in situ hybridization and immunostaining. We also examined the effect of pooled uremic sera from dialysis patients on the expression of Cbfa1 by reverse transcription-polymerase chain reaction (RT-PCR) in bovine VSMCs in vitro. Results. ...
https://indiana.pure.elsevier.com/en/publications/uremia-induces-the-osteoblast-differentiation-factor-cbfa1-in-hum
Cleidocranial | definition of cleidocranial by Medical dictionaryCleidocranial | definition of cleidocranial by Medical dictionary
Looking for online definition of cleidocranial in the Medical Dictionary? cleidocranial explanation free. What is cleidocranial? Meaning of cleidocranial medical term. What does cleidocranial mean?
http://medical-dictionary.thefreedictionary.com/cleidocranial
Mutations in the RUNX2 gene in patients with cleidocranial dysplasiaMutations in the RUNX2 gene in patients with cleidocranial dysplasia
Cleidocranial dysplasia (CCD) is a autosomal dominant disorder characterized by skeletal anomalies such as patent fontanels, late closure of cranial sutures with Wormian bones, late erupting secondary dentition, rudimentary clavicles, and short stature. The locus for this disease was mapped to chrom …
https://pubmed.ncbi.nlm.nih.gov/11857736/?dopt=Abstract
IJMS | Free Full-Text | Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?IJMS | Free Full-Text | Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?
Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are important in determining peak bone mass and structure, as well as the predisposition to bone deterioration and fragility fractures. Nonetheless, genetic factors alone are not sufficient to explain osteoporosis development and fragility fracture occurrence. Indeed, epigenetic factors, representing a link between individual genetic aspects and environmental influences, are also strongly suspected to be involved in bone biology and osteoporosis. Recently, alterations in epigenetic mechanisms and their activity have been associated with aging. Also, bone metabolism has been demonstrated to be under the control of epigenetic mechanisms. Runt-related transcription factor 2 (RUNX2), the master transcription factor of osteoblast differentiation, has been shown to be regulated by histone deacetylases and microRNAs (miRNAs). Some miRNAs were also proven to have key roles in the regulation of Wnt signalling in osteoblastogenesis
http://www.mdpi.com/1422-0067/17/8/1329
Plus itPlus it
Currently, no model is available to study the cellular and molecular events associated with bone metastases of prostate cancer. This study shows that MDA PCa 2a and MDA PCa 2b cells induce a specific and reproducible increase in osteoblast differentiation and proliferation when the cells share the medium during coculturing. Osteoblast differentiation in this system was associated with up-regulation of the osteoblast-specific transcriptor factor Cbfa1. Moreover, up-regulation of Cbfa1 and Osteocalcin expression was also induced in PMOs by CM produced by MDA PCa 2b cells, suggesting that soluble factors produced by prostate cancer cells promote osteoblast differentiation and that Cbfa1 mediates this effect. To our knowledge, this is the first in vitro model of bone metastasis from prostate cancer that recapitulates the osteoblastic phenotype typical of the disease. These results confirmed in vivo and at the molecular level, suggest that the pathophysiology of osteoblastic bone metastases from ...
http://cancerres.aacrjournals.org/content/61/14/5652
Osteocalcin (Mouse) Detection: ELISAs and AntibodiesOsteocalcin (Mouse) Detection: ELISAs and Antibodies
Gla-osteocalcin and Glu-osteocalcin can be assayed concurrently with the Mouse Gla-Osteocalcin High Sensitive EIA Kit (Cat. # MK127) and Mouse Glu-Osteocalcin High Sensitive EIA Kit (Cat. # MK129), respectively. These mouse osteocalcin ELISA kits allow for the relative evaluation of Gla/Glu-osteocalcins, thereby providing a measure of both bone formation and bone resorption.. These kits use a sandwich ELISA strategy to specifically detect the Gla and Glu forms of osteocalcin. The capture antibody is a plate-bound solid-phased rat monoclonal antibody that specifically recognizes the C-terminal region of mouse osteocalcin. This is paired with labeled monoclonal antibodies that are specific for captured Glu-type or Gla-type osteocalcin. Because mouse osteocalcin has C-terminal sequences that differ from other mammals, it is possible to measure mouse osteocalcin without any cross-reaction with bovine antigens. Therefore, the process of osteoblastic cell differentiation can be monitored in ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Osteocalcin_Mouse?sitex=10020:22372:US&PEBCL1=lU3ZZrMN4ulS3E5aW7KEIoxy7L&PEBCL1_pses=ZGAB93E19422ACD56A49A905AF47DE5A5C1CDD1B1098E068C2FFDD08DAF590F0CDC315E4B045E65DEDC7A87CBBE0C73BDA0F05D783CE2FE9C5
Osteocalcin (Mouse) Detection: ELISAs and AntibodiesOsteocalcin (Mouse) Detection: ELISAs and Antibodies
Gla-osteocalcin and Glu-osteocalcin can be assayed concurrently with the Mouse Gla-Osteocalcin High Sensitive EIA Kit (Cat. # MK127) and Mouse Glu-Osteocalcin High Sensitive EIA Kit (Cat. # MK129), respectively. These mouse osteocalcin ELISA kits allow for the relative evaluation of Gla/Glu-osteocalcins, thereby providing a measure of both bone formation and bone resorption.. These kits use a sandwich ELISA strategy to specifically detect the Gla and Glu forms of osteocalcin. The capture antibody is a plate-bound solid-phased rat monoclonal antibody that specifically recognizes the C-terminal region of mouse osteocalcin. This is paired with labeled monoclonal antibodies that are specific for captured Glu-type or Gla-type osteocalcin. Because mouse osteocalcin has C-terminal sequences that differ from other mammals, it is possible to measure mouse osteocalcin without any cross-reaction with bovine antigens. Therefore, the process of osteoblastic cell differentiation can be monitored in ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Osteocalcin_Mouse?sitex=10020:22372:US&PEBCL1=lnhwdK4CkW3iarHzcIk8GWI879&PEBCL1_pses=ZG26FBD6714E5F088CA30DF34BDB5448E0DB651FC445E884971DD71D43D02E5BC856C3C0FEFEA1217FE3C766596EEE457D6B45B26F234A983C
Updates on the hematologic tumor microenvironment and its therapeutic targeting | HaematologicaUpdates on the hematologic tumor microenvironment and its therapeutic targeting | Haematologica
Work from Dr. Rafiis laboratory, among others, has revealed the heterogeneity of endothelial cells, which comprise over 140 different types of endothelium in the human body. Each organ or tumor is vascularized by a specialized endothelium. It is believed that transcription factors belonging to the Ets family, such as Ets variant 2 (ETV2), Fli1 and the Ets-related gene (Erg), make endothelial cells organ-specific. Endothelial cells are important niche cells for hematopoietic stem cells (HSC) and their use as feeder cells in culture allows the expansion of HSC by ~150-fold.1 As a refinement, a combination of reprogramming factors, including FBJ murine osteosarcoma viral oncogene homolog B (FOSB), growth factor independent 1 transcriptional repressor (GFI1), runt-related transcription factor 1 (RUNX1) and SPI1 (which encodes PU.1), can be combined with sustained vascular niche induction to generate HSC that are endowed with secondary repopulating activity.. However, a maladapted vascular niche can ...
https://haematologica.org/article/view/9077
DSpace at EWHA: Src enhances osteogenic differentiation through phosphorylation of OsterixDSpace at EWHA: Src enhances osteogenic differentiation through phosphorylation of Osterix
Osterix, a zinc-finger transcription factor, is required for osteoblast differentiation and new bone formation during embryonic development. The c-Src of tyrosine kinase is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization. Src activity is tightly regulated and its dysregulation leads to constitutive activation and cellular transformation. The function of Osterix can be also modulated by post-translational modification. But the precise molecular signaling mechanisms between Osterix and c-Src are not known. In this study we investigated the potential regulation of Osterix function by c-Src in osteoblast differentiation. We found that c-Src activation increases protein stability, osteogenic activity and transcriptional activity of Osterix. The siRNA-mediated knockdown of c-Src decreased the protein levels and transcriptional activity of Osterix. Conversely, Src specific inhibitor, SU6656, decreased ...
http://dspace.ewha.ac.kr/handle/2015.oak/217215
Plus itPlus it
Breast cancer is one of the most common malignant diseases in women. Epithelial-mesenchymal transition (EMT) has been documented to play an important role in proliferation, invasion and metastasis of tumor cells as well as drug resistance. Even though the signal transducer and activator of transcription 3 (STAT3) is not a master transcription factor of EMT, STAT3 is involved in the regulation of EMT-related gene expression. However, it remains unclear whether targeted inhibitors of STAT3 affect EMT-mediated proliferation, migration, invasion and drug resistance of tumor cells. In this paper, we investigated the effects of STAT3 and its interaction with Twist, a master transcription factor, in EMT program and subsequent changes in proliferation, migration and invasion of breast cancer cells by interfering STAT3 signaling pathway with different strategies such as STAT3 inactivation and STAT3 silencing. Furthermore, we explored the role of inhibiting STAT3 phosphorylation in the EMT regulation of ...
http://cancerres.aacrjournals.org/content/77/13_Supplement/LB-082
c-Src and IL-6 inhibit osteoblast differentiation and integrat...c-Src and IL-6 inhibit osteoblast differentiation and integrat...
c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling.: Interleukin-6 (IL-6) and c-Src impair osteoblast maturation in vitro and in
https://www.mysciencework.com/publication/show/c-src-il-6-inhibit-osteoblast-differentiation-integrate-igfbp5-signalling-0e08cd65
JCI - The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolutionJCI - The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution
FOXP3+CD4+ regulatory T cells (Tregs) are critical for immune homeostasis and respond to local tissue cues, which control their stability and function. We explored here whether developmental endothelial locus-1 (DEL-1), which, like Tregs, increases during resolution of inflammation, promotes Treg responses. DEL-1 enhanced Treg numbers and function at barrier sites (oral and lung mucosa). The underlying mechanism was dissected using mice lacking DEL-1 or expressing a point mutant thereof, or mice with T cell-specific deletion of the transcription factor RUNX1, identified by RNA sequencing analysis of the DEL-1-induced Treg transcriptome. Specifically, through interaction with αvβ3 integrin, DEL-1 promoted induction of RUNX1-dependent FOXP3 expression and conferred stability of FOXP3 expression upon Treg restimulation in the absence of exogenous TGF-β1. Consistently, DEL-1 enhanced the demethylation of the Treg-specific demethylated region (TSDR) in the mouse Foxp3 gene and the suppressive ...
https://www.jci.org/articles/view/137530/ga
AID 638977 - Induction of osteoblast differentiation in mouse C2C12 cells assessed as increase in ALP promoter activity...AID 638977 - Induction of osteoblast differentiation in mouse C2C12 cells assessed as increase in ALP promoter activity...
BioAssay record AID 638977 submitted by ChEMBL: Induction of osteoblast differentiation in mouse C2C12 cells assessed as increase in ALP promoter activity measured 48 hrs by luciferase reporter gene analysis.
https://pubchem.ncbi.nlm.nih.gov/bioassay/638977
Engineering surfaces to direct integrin binding and signaling to promote osteoblast differentiation - pdf descargar
Engineering surfaces to direct integrin binding and signaling to promote osteoblast differentiation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun7/149809785827-Engineering-surfaces-to-direct-integrin-binding-and-signaling-to-promote-osteoblast-differentiation.php
RUNX3/CBFA3 Antibody (2B10E8) [DyLight 488] (NBP2-22391G): Novus BiologicalsRUNX3/CBFA3 Antibody (2B10E8) [DyLight 488] (NBP2-22391G): Novus Biologicals
Mouse Monoclonal Anti-RUNX3/CBFA3 Antibody (2B10E8) [DyLight 488]. Validated: WB, Flow, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
https://www.novusbio.com/products/runx3-cbfa3-antibody-2b10e8_nbp2-22391g
Xp3 (panel A), GZMB (panel B), RUNX3 (panel C) immunostaining. *P | FGFR/VEGFR inhibitor-vegfrinhibitor.com
Xp3 (panel A), GZMB (panel B), RUNX3 (panel C) immunostaining. *P,0,05 vs NM; { P,0,05 vs CRC. RUNX3 level in CD8+ T cells coexpressing (white bars) and not
http://www.vegfrinhibitor.com/2017/08/24/xp3-panel-a-gzmb-panel-b-runx3-panel-c-immunostaining-p/
RUNX2RUNX2
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that ... The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants ... This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for ... The phosphorylation state of Runx2 also mediates its DNA-binding activity. The Runx2 DNA-binding activity is correlated with ...
https://en.wikipedia.org/wiki/RUNX2
Runt domainRunt domain
... core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and ... The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role ... highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit ... The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. In ...
https://en.wikipedia.org/wiki/Runt_domain
RUNX1RUNX1
... or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. RUNX1 is a ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...
https://en.wikipedia.org/wiki/RUNX1
Sigma factorSigma factor
Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... subunits) binds a sigma factor to form a complex called the RNA polymerase holoenzyme. It was previously believed that the RNA ... The core RNA polymerase (consisting of 2 alpha (α), 1 beta (β), 1 beta-prime (β'), and 1 omega (ω) ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ...
https://en.wikipedia.org/wiki/Sigma_factor
TAF9TAF9
This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several ... The protein complex that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to ... "Induced alpha helix in the VP16 activation domain upon binding to a human TAF". Science. 277 (5330): 1310-3. doi:10.1126/ ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ...
https://en.wikipedia.org/wiki/TAF9
Sec61 alpha 1Sec61 alpha 1
Chen Y; Le Cahérec F; Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. GRCh38: ... Knight BC; High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene. The protein ...
https://en.wikipedia.org/wiki/Sec61_alpha_1
RNA polymeraseRNA polymerase
... subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. A sigma (σ) factor binds to the core, ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) ... The core enzyme has five subunits (~400 kDa): β′ The β′ subunit is the largest subunit, and is encoded by the rpoC gene. The β ... The ω subunit facilitates assembly of RNAP and stabilizes assembled RNAP. In order to bind promoters, RNAP core associates with ...
https://en.wikipedia.org/wiki/RNA_polymerase
CBFBCBFB
... it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and ... Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family ...
https://en.wikipedia.org/wiki/CBFB
TAF11TAF11
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 ... The conserved region contains four alpha helices and three loops arranged as in histone H3. TAF11 has been shown to interact ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ...
https://en.wikipedia.org/wiki/TAF11
TBP-associated factorTBP-associated factor
TATA box-binding protein-associated factor) subunits (TAF1A, TAF1B, and TAF1C). These TAFs do not have a histone-like fold ... It contains two short alpha helices and a long central alpha helix. TAF1 (TAFII250) TAF2 (CIF150) TAF3 (TAFII140) TAF4 ( ... for example the downstream promoter element or gene-specific core promoter sequence Due to such interactions, they contribute ... The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a ...
https://en.wikipedia.org/wiki/TBP-associated_factor
Bacterial transcriptionBacterial transcription
... which include two alphas, a beta, and a beta prime (α, α, β, and β'). A fifth subunit, sigma (called the σ-factor), is only ... The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ...
https://en.wikipedia.org/wiki/Bacterial_transcription
POLR2JPOLR2J
"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599-606. doi:10.1006/jmbi. ... POLR2J has been shown to interact with: Apoptosis antagonizing transcription factor, POLR2C, and SATB1. GRCh38: Ensembl release ... The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of ...
https://en.wikipedia.org/wiki/POLR2J
EIF-W2 protein domainEIF-W2 protein domain
"Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by ... The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core ... The W2 domain has a globular fold and is exclusively composed out of alpha-helices. ... the eIF-W2 domain functions as the binding site for Mnk eIF4E kinase, an enzyme that phosphorylates eukaryotic initiation ...
https://en.wikipedia.org/wiki/EIF-W2_protein_domain
Cyclin DCyclin D
This contains a core of two compact domains with each having five alpha helices. The first five-helix bundle is a conserved ... Viral cyclin D binds human Cdk6 and inhibits Rb by phosphorylating it, resulting in free transcription factors which result in ... A simplification in yeast is that all cyclins bind to the same Cdc subunit, the Cdc28. Cyclins in yeast are controlled by ... A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast ...
https://en.wikipedia.org/wiki/Cyclin_D
SEC61BSEC61B
This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 ... Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ... Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...
https://en.wikipedia.org/wiki/SEC61B
TAF15TAF15
The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a ... This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and ... TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription ...
https://en.wikipedia.org/wiki/TAF15
Ars operonArs operon
It belongs to the thioredoxin superfamily fold which is defined by a beta-sheet core surrounded by alpha-helices. The active ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... Li S, Rosen BP, Borges-Walmsley MI, Walmsley AR (July 2002). "Evidence for cooperativity between the four binding sites of ... The arsC family also comprises the Spx proteins which are Gram-positive bacterial transcription factors that regulate the ...
https://en.wikipedia.org/wiki/Ars_operon
EGLN1EGLN1
In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... "Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases". Structure. 17 (7): 981-9. ... The catalytic domain consists of a double-stranded β-helix core that is stabilized by three α-helices packed along the major β- ... X-ray crystallography and NMR spectroscopy showed that both peptides bind to the same binding site on PHD2, in a cleft on the ...
https://en.wikipedia.org/wiki/EGLN1
STAT4STAT4
"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... Binding of IL-12 to IL-12R, which is composed of two different subunits (IL12Rβ1 and IL12Rβ2), leads to the interaction of ... "Increased sensitivity to interferon-alpha in psoriatic T cells". The Journal of Investigative Dermatology. 125 (5): 936-44. doi ... association with regulatory factors; 3. central DNA-binding domain - binding to the enhancer region of IFN-γ activated sequence ...
https://en.wikipedia.org/wiki/STAT4
PSMD10PSMD10
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
https://en.wikipedia.org/wiki/PSMD10
PPP2R1APPP2R1A
Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and ... 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure ... Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. ... It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, ...
https://en.wikipedia.org/wiki/PPP2R1A
Receptor (biochemistry)Receptor (biochemistry)
... alpha), β (beta), and γ (gamma). In the inactive state, the three subunits associate together and the α-subunit binds GDP. G ... They are composed of a C-terminal ligand-binding region, a core DNA-binding domain (DBD) and an N-terminal domain that contains ... The N terminus interacts with other cellular transcription factors in a ligand-independent manner; and, depending on these ... GTP-binding to the α-subunit causes dissociation of the β- and γ-subunits. Furthermore, the three subunits, α, β, and γ have ...
https://en.wikipedia.org/wiki/Receptor_(biochemistry)
List of MeSH codes (D12.776.930)List of MeSH codes (D12.776.930)
... core binding factor alpha 2 subunit MeSH D12.776.930.155.200.300 - core binding factor alpha 3 subunit MeSH D12.776.930.316. ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.155.200.100 - core binding factor alpha 1 subunit MeSH D12.776.930.155 ... CCAAT-binding factor MeSH D12.776.930.127.124.500 - CCAAT-enhancer-binding protein-alpha MeSH D12.776.930.127.124.750 - CCAAT- ... alpha subunit MeSH D12.776.930.125.750.590 - myod protein MeSH D12.776.930.125.750.595 - myogenic regulatory factor 5 MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.930)
EPRSEPRS
A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors". J Biol Chem. 266 (3): ... 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys ... 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97 ... identification of RNA-binding residues and functional implications for tandem repeats". Biochemistry. 39 (51): 15775-82. doi: ...
https://en.wikipedia.org/wiki/EPRS
RUNX3RUNX3
A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a ... Core binding factor RUNX1 RUNX2 GRCh38: Ensembl release 89: ENSG00000020633 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1". Oncogene. 8 (3): ... Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene. This gene encodes a member of the ...
https://en.wikipedia.org/wiki/RUNX3
GTF2A1LGTF2A1L
This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ... pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding ... TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. The assembly and stability of the ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ...
https://en.wikipedia.org/wiki/GTF2A1L
MyogeninMyogenin
"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proceedings of the National Academy of Sciences of the United ... "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation ... myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, ...
https://en.wikipedia.org/wiki/Myogenin
Tbf5 protein domainTbf5 protein domain
... general transcription factor 2H subunit 5) is also known as the TTD group A (TTDA) subunit (and as Tfb5). The TTDA subunit is ... and part of a six-subunit complex of Rad3, Tfb1, Tfb2, Tfb4, Tfb5, and Ssl1 (referred to as core) In humans, the function of ... TTDA is present both bound to TFIIH, and as a free fraction that shuffles between the cytoplasm and nucleus; induction of NER- ... These proteins have a structural motif consisting of a 2-layer sandwich structure with an alpha/beta plait topology. ...
https://en.wikipedia.org/wiki/Tbf5_protein_domain
PSMC5PSMC5
"The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative ... which interacts with the seven-membered alpha ring of 20S core particle and establishes an asymmetric interface between the 19S ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
https://en.wikipedia.org/wiki/PSMC5
Eukaryotic small ribosomal subunit (40S)Eukaryotic small ribosomal subunit (40S)
... being bound by several eukaryotic initiation factors, including eIF1, eIF1A, and eIF3. The 40S ribosomal subunit is also ... This rRNA core is decorated with dozens of proteins. In the figure "Crystal Structure of the Eukaryotic 40S Ribosomal Subunit ... Eukaryote-specific extensions of conserved proteins, ranging from a few residues or loops to very long alpha helices and ... Crystal structure of the eukaryotic 40S ribosomal subunit from T. thermophila 40S subunit viewed from the subunit interface ...
https://en.wikipedia.org/wiki/Eukaryotic_small_ribosomal_subunit_(40S)
PSMD7PSMD7
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... These subunits can be categorized into two classes based on the ATP dependence of subunits, ATP-dependent subunits and ATP- ...
https://en.wikipedia.org/wiki/PSMD7
Promoter (genetics)Promoter (genetics)
November 1993). "A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase". ... RNA polymerase holoenzymes containing other sigma factors recognize different core promoter sequences. <-- upstream downstream ... In the case of a transcription factor binding site, there may be a single sequence that binds the protein most strongly under ... An inactive enhancer may be bound by an inactive transcription factor. Phosphorylation of the transcription factor may activate ...
https://en.wikipedia.org/wiki/Promoter_(genetics)
Glucocorticoid receptorGlucocorticoid receptor
However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... "Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the ... The role of alpha and beta isoforms of the glucocorticoid receptor]". Archivos de Bronconeumologia. 38 (9): 436-440. doi: ... DNA-binding domain (DBD) D - hinge region E - ligand-binding domain (LBD) F - C-terminal domain In the absence of hormone, the ...
https://en.wikipedia.org/wiki/Glucocorticoid_receptor
PSMB3PSMB3
... the two end rings are each formed by 7 alpha subunits, and the two central rings are each formed by 7 beta subunits. Three beta ... The gene PSMB3 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...
https://en.wikipedia.org/wiki/PSMB3
DDB1DDB1
2002). "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV ... Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ... 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97 ... 2002). "The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 ...
https://en.wikipedia.org/wiki/DDB1
CAAT boxCAAT box
These core binding factors, or nuclear factors (NF-Y), are composed of three subunits - NF-YA, NF-YB, and NF-YC. Whereas in ... The first domain (A1) contains 20 amino acids that forms an alpha helix that appears significant in its interactions with NF-YB ... It is essential to the transcription that these core binding factors (also referred to as nuclear factor Y or NF-Y) are able to ... the core binding factor (CBF)-DNA complex retains a high degree of conservation within the CCAAT binding motif, as well as the ...
https://en.wikipedia.org/wiki/CAAT_box
Chromosome 16Chromosome 16
... encoding protein VPS35 Endosomal Protein Sorting Factor Like WFDC1: encoding protein WAP four-disulfide core domain protein 1 ... So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. The following is a ... alpha pseudogene 1 HBHR, ATR1: Alpha-thalassemia/mental retardation syndrome, type 1 HIRIP3: encoding protein HIRA-interacting ... encoding protein SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) SNAI3-AS1: encoding protein SNAI3 ...
https://en.wikipedia.org/wiki/Chromosome_16
Regulator of G protein signalingRegulator of G protein signaling
... with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit ... is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11916-20. doi: ... a pheromone desensitization factor in Saccharomyces cerevisiae". Mol Cell Biol. 15 (7): 3635-43. doi:10.1128/MCB.15.7.3635. PMC ... G protein gamma subunit-like) for binding G protein beta subunits (InterPro: IPR001770 Those RGS proteins that contain GGL ...
https://en.wikipedia.org/wiki/Regulator_of_G_protein_signaling
Cadherin-catenin complex in learning and memoryCadherin-catenin complex in learning and memory
Expression of lymphoid enhancer-binding factor 1 (LEF-1) triggers the translocation of β-catenin to the nucleus, where it ... Protocadherin-alpha and protocadherin-gamma interact to form a protein complex that enhances the surface expression of each ... Davis, MA; Ireton, RC; Reynolds, AB (2003). "A core Function for p120-catenin in cadherin turnover". J. Cell Biol. 163 (3): 525 ... impaired the stabilization of GluR2 and GluR3 AMPAR subunits, respectively, at the plasma membrane. Co-localization of p120ctn ...
https://en.wikipedia.org/wiki/Cadherin–catenin_complex_in_learning_and_memory
H4K8acH4K8ac
These core histones are rich in lysine and arginine residues. The carboxyl (C) terminal end of these histones contribute to ... It results in good optimization and is used in vivo to reveal DNA-protein binding occurring in cells. ChIP-Seq can be used to ... H4K8ac indicates acetylation of lysine 8 on histone H4 protein subunit: The genomic DNA of eukaryotic cells is wrapped around ... Maruta H, Greer K, Rosenbaum JL (1986). "The acetylation of alpha-tubulin and its relationship to the assembly and disassembly ...
https://en.wikipedia.org/wiki/H4K8ac
Anticancer geneAnticancer gene
p53 is unique as a transcription factor in that it can recognize and bind response elements (RE) in many different environments ... One of the two molecules of this complex is multimeric alpha lactalbumin (MAL) (Figure 3), which was first discovered during a ... "Identification of a Unique Core Domain of Par-4 Sufficient for Selective Apoptosis Induction in Cancer Cells". Molecular and ... that the mechanisms behind the function of E4orf4 is closely associated with several other proteins including the B55 subunit ...
https://en.wikipedia.org/wiki/Anticancer_gene
UbiquitinUbiquitin
Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex ... Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (March 1999). "A novel ubiquitination factor, E4, is involved in ... This is a barrel-shape structure comprising a central proteolytic core made of four ring structures, flanked by two cylinders ... alpha} via the N-terminal pathway". The Journal of Biological Chemistry. 285 (51): 40192-200. doi:10.1074/jbc.M110.131615. PMC ...
https://en.wikipedia.org/wiki/Ubiquitin
PSMD5PSMD5
The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are ... Deveraux Q, Ustrell V, Pickart C, Rechsteiner M (1994). "A 26 S protease subunit that binds ubiquitin conjugates". J. Biol. ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes ...
https://en.wikipedia.org/wiki/PSMD5
Small GTPaseSmall GTPase
... but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and ... Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity. The ... while GTP exchange is catalyzed by guanine nucleotide exchange factors (GEFs). Activation of a GEF typically activates its ... A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ...
https://en.wikipedia.org/wiki/Small_GTPase
SNAP25SNAP25
Synaptobrevin binds the α-helix near the C-terminus of SNAP-25, while syntaxin-1 binds the α-helix near the N-terminus. ... The core symptoms comprise intellectual disability ranging between mild to profound and early-onset seizures mostly occurring ... Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a ... Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein ...
https://en.wikipedia.org/wiki/SNAP25
EndophenotypeEndophenotype
Leiser SC, Bowlby MR, Comery TA, Dunlop J (June 2009). "A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is ... FABP7, coding the Fatty acid-binding protein 7 (brain), one SNP of which was associated with schizophrenia in one 2008 study, ... Alderson RM, Rapport MD, Hudec KL, Sarver DE, Kofler MJ (May 2010). "Competing core processes in attention-deficit/ ... CHRNA7, coding the neuronal nicotinic acetylcholine receptor alpha7 subunit. alpha7-containing receptors are known to improve ...
https://en.wikipedia.org/wiki/Endophenotype
PSMD14PSMD14
The subunit Rpn12 incorporated into 19S regulatory particle when 19S lid and base bind together. Among these lid subunits, ... as well as to cause conformational changes to the alpha subunit C-terminals that form the substate entrance of the 20S complex ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... The 26S proteasome complex usually consists of a 20S core particle (CP, or 20S proteasome) and one or two 19S regulatory ...
https://en.wikipedia.org/wiki/PSMD14
G beta-gamma complexG beta-gamma complex
Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, ... The Gβγ subunit has been shown to activate a Rho guanine nucleotide exchange factor (RhoGef) gene PLEKHG2 which is upregulated ... N terminus helical domains of the two subunits form a coiled coil with one another that typically extends away from the core of ... The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a ...
https://en.wikipedia.org/wiki/G_beta-gamma_complex
Homeobox protein MSX-1Homeobox protein MSX-1
"Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ... MSX1 has been shown to interact with DLX5, CREB binding protein, Sp1 transcription factor, DLX2, TATA binding protein and Msh ... encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core ... "Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ...
https://en.wikipedia.org/wiki/Homeobox_protein_MSX-1
S100A10S100A10
Akiba S, Hatazawa R, Ono K, Hayama M, Matsui H, Sato T (Nov 2000). "Transforming growth factor-alpha stimulates prostaglandin ... Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... Munz B, Gerke V, Gillitzer R, Werner S (Mar 1997). "Differential expression of the calpactin I subunits annexin II and p11 in ... by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. The ...
https://en.wikipedia.org/wiki/S100A10
Phosphatidylinositol 4,5-bisphosphatePhosphatidylinositol 4,5-bisphosphate
... which is initiated by ligands binding to G protein-coupled receptors activating the Gq alpha subunit. PtdIns(4,5)P2 is a ... 2004). "CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP 2 binding protein". Neuron. 43 (4): 551-562. ... Some of the factors involved in PIP2 regulation are: Lipid kinases, Lipid Phosphatase Lipid Transfer Proteins Growth Factors, ... PIP2 has been shown to recruit G protein-coupled receptor kinase 2 (GRK2) to the membrane by binding to the large lobe of GRK2 ...
https://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate
PSMA3PSMA3
"A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome ... This barrel-shaped core structure is composed of 4 axially stacked rings of 28 non-identical subunits: the two end rings are ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... As a component of alpha ring, proteasome subunit alpha type-3 contributes to the formation of heptameric alpha rings and ...
https://en.wikipedia.org/wiki/PSMA3
AAA proteinsAAA proteins
In the hexameric configuration, the ATP-binding site is positioned at the interface between the subunits. Upon ATP binding and ... an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold) and a C-terminal alpha-helical domain. ... AAA proteins are divided into seven basic clades, based on secondary structure elements included within or near the core AAA ... "Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP". Nat. Struct. ...
https://en.wikipedia.org/wiki/AAA_proteins
Francis CrickFrancis Crick
... the alpha helix). Linus Pauling was the first to identify the 3.6 amino acids per helix turn ratio of the alpha helix. Crick ... It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, ... Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 ... one factor being that the new college did not have a chapel. Some time later a large donation was made to establish a chapel ...
https://en.wikipedia.org/wiki/Francis_Crick
CellulaseCellulase
... the position where the substrate binds, may influence factors like binding affinity of ligands, stabilization of substrates ... The number of sub-units making up cellulosomes can also determine the rate of enzyme activity. Multidomain cellulases are ... McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-β-D-glucanase". ... construction of the catalytic core, expression, and X-ray structure at 1.75 Å resolution". Biochemistry. 36 (51): 16032-9. doi: ...
https://en.wikipedia.org/wiki/Cellulase
Murine respirovirusMurine respirovirus
... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... The SeV virion also contains the nucleocapsid core, which is composed of the genomic RNA, the nucleocapsid protein (NP), the ... tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor-beta (TNF-beta), interleukin-6 (IL-6 ), interleukin-8 (IL-8), ...
https://en.wikipedia.org/wiki/Murine_respirovirus
IronIron
Since 56Ni (14 alpha particles) is easily produced from lighter nuclei in the alpha process in nuclear reactions in supernovae ... As such, iron is the most abundant element in the core of red giants, and is the most abundant metal in iron meteorites and in ... Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... The ensuing availability of inexpensive iron was one of the factors leading to the Industrial Revolution. Toward the end of the ...
https://en.wikipedia.org/wiki/Iron
PSMB10PSMB10
Proteasome subunit beta type-10 is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and ... that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is ... Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... STAT3, sterol-regulated element-binding proteins and androgen receptors are all controlled by the UPS and thus involved in the ...
https://en.wikipedia.org/wiki/PSMB10
RUNX2 gene: MedlinePlus GeneticsRUNX2 gene: MedlinePlus Genetics
SL3/AKV core-binding factor alpha A subunit. Additional Information & Resources. Tests Listed in the Genetic Testing Registry. ... The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the ... 2013 Jan;24(1):130-3. doi: 10.1097/SCS.0b013e3182636b7e. Citation on PubMed ...
https://medlineplus.gov/genetics/gene/runx2/
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in...
Core Binding Factor Alpha 1 Subunit 100% * DNA 8% * Gene Expression 8% ... Dive into the research topics of Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast ... Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in ...
https://mayoclinic.pure.elsevier.com/en/publications/impaired-intranuclear-trafficking-of-runx2-aml3cbfa1-transcriptio/fingerprints/?sortBy=alphabetically
骨科學科 - 研究成果 - 臺北醫學大學
Core Binding Factor Alpha 1 Subunit 58% 16 引文 斯高帕斯（Scopus） ... Usage of growth factors in acute muscle injuries. Chen, C. H., Lee, C. H. & Chang, C. H., 1月 1 2015, Sports Injuries: ... Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center. Lee, C. ... Chen, Y. P., Wu, C. C. & Ho, W. P., 3月 1 2016, 於: Indian Journal of Orthopaedics. 50, 2, p. 146-153 8 p.. 研究成果: 雜誌貢獻 › 文章 › 同行評 ...
https://tmu.pure.elsevier.com/zh/organisations/department-of-orthopedics/publications/?ordering=publicationYearThenTitle&descending=false&page=3
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγtT-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt
Here we report that the transcription factor T-bet suppressed dev … ... yet the factors that negatively regulate the differentiation of this lineage remain unknown. ... Core Binding Factor Alpha 2 Subunit / immunology * Core Binding Factor Alpha 2 Subunit / metabolism* ... which encodes the transcription factor RORγt). T-bet interacted with the transcription factor Runx1, and this interaction ...
https://pubmed.ncbi.nlm.nih.gov/21151104/
DeCSDeCS
Core Binding Factor Alpha 2 Subunit [D12.776.930.155.200.200] Core Binding Factor Alpha 2 Subunit ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... Core Binding Factor Alpha 1 Subunit Descriptor Spanish: Subunidad alfa 1 del Factor de Unión al Sitio Principal Spanish from ...
https://decs.bvsalud.org/en/ths/resource/?id=51176
Ke Yuan, Ph.D. | Harvard Catalyst Profiles | Harvard CatalystKe Yuan, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Core Binding Factor Alpha 1 Subunit. *COS Cells. *Cyclosporine. *Cytokines. *Databases, Factual ... alpha Subunit. *Immunoglobulin G. *Immunohistochemistry. *Inflammation. *Integrin alpha3 ...
https://connects.catalyst.harvard.edu/Profiles/display/Person/185345/Network/ResearchAreas
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. | Scholars@DukeEts-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. | [email protected]
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. ... Core Binding Factor Alpha 1 Subunit * Gene Expression Regulation, Neoplastic * Liver Neoplasms ... Gel-shift assays sublocalized two cis-regulatory regions, nt -101 to -123 and nt -121 to -145, which specifically bind CT26 ... Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. ...
https://scholars.duke.edu/display/pub668301
Bone lengthening. Medical searchBone lengthening. Medical search
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly ... DietaryAcid PhosphatasePhosphorusReceptor Activator of Nuclear Factor-kappa BBiocompatible MaterialsCore Binding Factor Alpha 1 ... Transforming Growth Factor beta. A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in ... A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF ...
https://lookformedical.com/en/search/bone-lengthening
Phillip Tai's co-authors | Profiles RNS
Core Binding Factor Alpha 1 Subunit * Osteoblasts * Transduction, Genetic Explore _. Co-Authors (40) ...
https://profiles.umassmed.edu/display/16919122/Network/CoAuthors
Proteínas/farmacologiaProteínas/farmacologia
... core-binding factor subunit alpha-1/Runt-related transcription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin ... Furthermore, we identified that 14-3-3ζ and ε isoforms interact with NMDARs via binding to GluN2A and GluN2B subunits. Taken ... or GluN2B subunits. In heterologous cells, 14-3-3 proteins enhanced surface expression of these NMDAR subunits. ... In this study, we first identified es-Raptor (the core component of mTOR complex 1) and es-Rictor (the core component of mTOR ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Prote%C3%ADnas/farmacologia
Cancers | Free Full-Text | Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across...Cancers | Free Full-Text | Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across...
1 genomic alteration(s); 170/227 (75%), ≥1 potentially actionable alteration(s) targetable by an FDA-approved (mostly off- ... core-binding factor subunit alpha 2 (CBFA2) is a tumor suppressor. Mocetinostat (MGCD0103) or Sorafenib NCT00217646 **. ... PIK3R1 (PI3K regulatory subunit alpha). Copanlisib. NCT02369016 **. PTCH1. PTCH1 (Protein patched homolog 1) is a receptor for ... CSF1 (colony stimulating factor 1) regulates differentiation and survival. Chiauranib NCT03074825 **. CXCR4. CXCR4 (C-X-C ...
https://www.mdpi.com/2072-6694/11/1/11
SMART: PH domain annotationSMART: PH domain annotation
The entire sequence was 83% similar to centaurin alpha, another PtdIns(3,4,5)P3-binding protein. The protein bound PtdIns(3,4,5 ... The core of the molecule is an antiparallel beta-sheet consisting of seven strands. The C terminus is folded into a long alpha- ... The PH domain in beta-adrenergic receptor kinase may be involved in binding to the beta gamma subunits of a trimeric G-protein ... A family of NMR solution structures of the growth factor receptor-bound protein 2 (Grb2) SH2 domain has been determined by ...
https://smart.embl.de/smart/do_annotation.pl?DOMAIN=PH&START=381&END=480&E_VALUE=1.02e-14&TYPE=SMART&BLAST=VSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGT
Search | Global Index MedicusSearch | Global Index Medicus
Animals , Calcium Carbonate/metabolism , Core Binding Factor Alpha 1 Subunit/metabolism , Exosomes/metabolism , Humans , Male ... By using the drug metabolizing enzyme inhibitors, the effects of metabolic factors on potential liver injury induced by the ... Target genes of differential miRNA were mainly involved in membrane composition, mainly played molecular functions binding to ... which provides a reference to the evaluation of susceptible factors and drug incompatibility research of Polygonum multiflorum. ...
https://search.bvsalud.org/gim/?lang=en&q=au:%22Xiao-fei%20LI%22
The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in...The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in...
Core Binding Factor Alpha 1 Subunit. Embryo, Mammalian. Estrogens. Exons. Female. *Gene Expression Regulation, Enzymologic. ... Consistent with the presence of multiple Runx2 binding sites, the binding of Runx2 to the aromatase promoter was demonstrated ... The essential osteoblast-related transcription factor Runx2 and the female steroid hormone estrogen are known to play pivotal ...
https://repository.escholarship.umassmed.edu/handle/20.500.14038/49492
RUNX1 AnticorpsRUNX1 Anticorps
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and ... The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal ... runt-related transcription factor (runt) Anticorps. runt related transcription factor 1 (Runx1) Anticorps. runt related ... "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers." dans: EBioMedicine, Vol. 8, pp. ...
https://www.anticorps-enligne.fr/ru/runx1-47177/runx1-antibodies-208/
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. - Radcliffe Department of MedicineRunx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. - Radcliffe Department of Medicine
Furthermore, binding of an Scl-Lmo2-Gata2 complex was demonstrated to occur on the regions flanking the conserved E-boxes of ... Bioinformatics analysis resulted in the identification of 9 candidate Scl target transcription factor genes, including Runx1 ... the precise mechanisms by which these factors interact to form transcriptional networks, as well as the identity of the genes ... Transcription factors such as Scl/Tal1, Lmo2, and Runx1 are essential for the development of hematopoietic stem cells (HSCs). ...
https://www.rdm.ox.ac.uk/publications/325084
Motif 1 Binding ProteinMotif 1 Binding Protein
A sequence-specific core promoter-binding transcription factor recruits TRF2 to coordinately transcribe ribosomal protein genes ... out of five subunits that comprise the male-specific lethal (MSL) complex in flies. Additionally, it binds to the promoter ... Using either the alpha fragment of LacZ as a control or full-length M1BP fused to Mal, it was determined that GFZF interacts ... A total of 3,013 genes are bound by M1BP, while 1,885 are bound by GFZF. Furthermore, both factors are bound almost exclusively ...
https://www.sdbonline.org/sites/FLY/genebrief/m1bp.htm
Gene P04584 | Protein gag-pol - Mutations | canSAR.aiGene P04584 | Protein gag-pol - Mutations | canSAR.ai
Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the pro ... The core is disassembled soon after virion entry (By similarity). Host restriction factors such as TRIM5-alpha or TRIMCyp bind ... Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. ... Binds to RNA., Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. ...
https://cansar.ai/target/P04584/mutations
IMP: Integrative Multi-species Prediction
core-binding factor, runt domain, alpha subunit 2; translocated to, 3. 0.039. ... transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha). 0.060. ... alpha subunit (basic helix-loop-helix transcription factor). 0.045. ... transcription factor AP-2 beta (activating enhancer binding protein 2 beta). 0.015. ...
http://imp.princeton.edu/predictions/process/human-context-global/4504/?gene=14820
ZFIN Publication: Bresciani et al., 2014ZFIN Publication: Bresciani et al., 2014
CCAAT-Binding Factor/metabolism. *Core Binding Factor Alpha 2 Subunit/genetics*. *Core Binding Factor Alpha 2 Subunit/ ... CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. ... Blood 124(1): 70-8 (Journal) Generate reference. Registered Authors. Bresciani, Erica, Gore, Aniket, Liu, Pu Paul, Sood, Raman ...
https://zfin.org/ZDB-PUB-140523-3
Browse Items · NEOMED Bibliography Database
Core Binding Factor Alpha 1 Subunit/genetics/metabolism, Gene Expression Regulation, Integrin-Binding Sialoprotein/genetics/ ... Integrin-Binding Sialoprotein, Isogai Noritaka, Jacquet Robin, Landis William J, Lowder Elizabeth, Mice, Microscopy, Paraffin ... Fibroblast Growth Factor 2/*pharmacology, Humans, International journal of pediatric otorhinolaryngology, Isogai Noritaka, ... Effects of FGF-2 and OP-1 in vitro on donor source cartilage for auricular reconstruction tissue engineering.. OBJECTIVE: ...
https://neomed.omeka.net/items/browse?tags=Landis+William+J
Browse ORF cDNA clones by species Pan troglodytes, letter g, page 1Browse ORF cDNA clones by species Pan troglodytes, letter g, page 1
You can Browse ORF cDNA clones by species Pan troglodytes, letter g, page 1 ... G protein subunit alpha i3. protein-coding. GPBP1L1. GC-rich promoter binding protein 1 like 1. protein-coding. ... general transcription factor IIH subunit 1. protein-coding. GPRASP2. G protein-coupled receptor associated sorting protein 2. ... core 2. protein-coding. GNAI1. G protein subunit alpha i1. protein-coding. ...
https://www.genscript.com/gene/9598/pan-troglodytes?search=g
Expression of eukaryotic translation initiation factors in murine B cells treated with 33 single ligandsExpression of eukaryotic translation initiation factors in murine B cells treated with 33 single ligands
... core complex, attesting to their dual functions in cellular machinery. eIF4, a complex consisting of 3 subunits with multiple ... Similar to eIF2s1, eIF4E can be phosphorylated by binding proteins, and these are seen to have differing levels of gene ... eIF3, a large complex with at least 10 subunits, is seen to have discordant regulation of its subunits as well, even for a ... eIF2, which is inactivated upon phosphorylation of subunit 1 by alpha kinases 1-4, was seen to have discordant regulation of ...
https://escholarship.org/uc/item/2j0396bm
SCOPe 2.06: Protein: Sigma factor SigRSCOPe 2.06: Protein: Sigma factor SigR
... anti-sigma factor binding domain. *. Domain d1h3lb_: 1h3l B: [76640]. truncated sigma2 domain core; anti-sigma factor binding ... Class a: All alpha proteins [46456] (289 folds). *. Fold a.177: Sigma2 domain of RNA polymerase sigma factors [88945] (1 ... RNA polymerase sigma subunit. *Protein Sigma factor SigR from a.177.1.1: Sigma2 domain of RNA polymerase sigma factors appears ... Sigma2 domain of RNA polymerase sigma factors. Timeline for Protein Sigma factor SigR from a.177.1.1: Sigma2 domain of RNA ...
http://scop.berkeley.edu/sunid=81883&ver=2.06
Reference - RRC(Research Resource Circulation)
Animals Base Sequence Bone and Bones / metabolism* Cell Line Cloning, Molecular Core Binding Factor Alpha 1 Subunit / genetics* ... alpha Subunit / physiology* Mice Mice, Transgenic Promoter Regions, Genetic* Transcriptional Activation* Transfection ... An electrophoretic mobility shift assay and chromatin immunoprecipitation assay confirmed the binding of HIF2A to the Runx2-P1 ... To identify upstream regulators of the Runx2-P1 promoter, we screened 100 transcription factors using Runx2-P1-luciferase ...
https://rrc.nbrp.jp/references/61279
"sequence id","alias","species","description",...
... alpha subunit [Ensembl]. DNA polymerase, OB-fold nucleic acid binding domain, DNA polymerase III alpha subunit finger domain, ... Elongation factor Tu domain 2, Elongation factor Tu C-terminal domain, Elongation factor Tu GTP binding domain [Interproscan ... ","Integrase core domain protein [Ensembl]. HTH-like domain, Integrase core domain [Interproscan].","protein_coding" "AKP16061 ... alpha subunit [Ensembl]. Molydopterin dinucleotide binding domain, Molybdopterin dinucleotide-binding domain [InterProScan]."," ...
https://bacteria.sbs.ntu.edu.sg/go/sequences/table/4847
RCSB PDB - 6I7T: eIF2B:eIF2 complexRCSB PDB - 6I7T: eIF2B:eIF2 complex
Translation initiation factor eIF-2B subunit alpha. A,. H [auth B]. 305. Saccharomyces cerevisiae. Mutation(s): 0 Gene Names: ... eIF2 undergoes large rearrangements to promote binding of eIF2α to the regulatory core of eIF2B comprised of the eIF2B alpha, ... Eukaryotic translation initiation factor 2 subunit alpha. K,. N [auth L]. 304. Saccharomyces cerevisiae. Mutation(s): 0 Gene ... Translation initiation factor eIF-2B subunit beta. D [auth E],. I [auth F]. 381. Saccharomyces cerevisiae. Mutation(s): 0 Gene ...
https://www.rcsb.org/structure/6I7T
List Component of the Bacterial RNA Polymerase Core Enzyme | Paper for Pay
rifampicin-sensitive alpha, beta, sigma and omega subunits. rifampicin-sensitive alpha and beta subunits, and rifampicin- ... Which of the following region in sigma factor binds to the core promoter -10 box? ... and rifampicin-resistant alpha and omega subunits. rifampicin-sensitive alpha and sigma subunits, and rifampicin-resistant beta ... rifampicin-sensitive alpha, beta and sigma subunits, and rifampicin-resistant omega subunits. ...
https://paperforpay.com/list-component-of-the-bacterial-rna-polymerase-core-enzyme/
Noninvasive Identification of Core Gene Biomarkers in Patients with Acute Kidney Transplant Rejection | Research SquareNoninvasive Identification of Core Gene Biomarkers in Patients with Acute Kidney Transplant Rejection | Research Square
XPO1 interacted with NCBP2 which is a subunit of the nuclear cap-binding complex to promote the pri-miRNA to pre-miRNA ... Levels of Alpha- And Beta-Secretase Cleaved Amyloid Precursor Protein in the Cerebrospinal Fluid of Alzheimers Disease ... There were a great many factors related to transplant patients occurring AR, but the primary mechanism to contribute to the AR ... Concerning MF, the up-regulated DEGs were primarily enriched in poly(A) RNA binding, ATP binding, nucleotide binding, protein ...
https://www.researchsquare.com/article/rs-105138/v1
trHuman | searchcodetrHuman | searchcode
9751756 TAS Core-binding factor subunit beta CBFB,IPI00016746,IPI00024871,PEBB_HUMAN PINC 93CBFB PMID:8351518 TAS Core-binding ... 1774067 TAS Nuclear transcription factor Y subunit alpha IPI00218470,IPI00333568,NFYA,NFYA_HUMAN PINC 665NFYA PMID:2000400 TAS ... factor subunit beta CBFB,IPI00016746,IPI00024871,PEBB_HUMAN PINC 94CBFB PMID:8351518 TAS Core-binding factor subunit beta CBFB, ... 7801123 TAS TATA box-binding protein-associated factor RNA polymerase I subunit A IPI00024263,IPI00157541,TAF1A,TAF1A_HUMAN ...
https://searchcode.com/total-file/354435/tools/expression/trHuman/
ProteinPolymeraseProteinsHeterodimeric transcriptionRUNX2MitochondrialGenesTRNARunx1Runt domainLigandPhosphorylationPutativeGene ExpressionEnhancer factorTranscription FactorsComplexesRegulateMotifRegulatoryComplexDomainSubstrateCellsEstrogenAssaysTumorBiologicalDsDNACartilageMoleculeGlycogeninZincHUMANEnzymeEIF2InhibitorBetaHomologInterferonBoneVirionFamilyCancersTranscriptional activatorMembraneHistone
Protein34
  • The RUNX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • Competition with unlabeled mutant oligonucleotides revealed that the regions nt -115 to -118 and nt -129 to -134 were essential for protein binding. (duke.edu)
  • Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. (duke.edu)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
  • The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. (anticorps-enligne.fr)
  • Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). (cansar.ai)
  • The core is constituted by capsid protein hexamer subunits. (cansar.ai)
  • Similar to eIF2s1, eIF4E can be phosphorylated by binding proteins, and these are seen to have differing levels of gene expression with various ligand stimulations, allowing for large variability in protein synthesis. (escholarship.org)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
  • protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
  • A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
  • The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. (embl-heidelberg.de)
  • A search for another PBCV-1-encoded and virion-associated protein identified protein A561L. (weizmann.ac.il)
  • Receptor-interacting serine/threonine-kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. (wikipathways.org)
  • It is a recombinant protein vaccine that forms approximately 30-nm nanoparticles based on hydrophobic interaction with a core polysorbate-80 micelle. (news-medical.net)
  • The NVX-CoV2373 antigen is formulated with Matrix-M adjuvant and uses stabilized prefusion S protein homotrimer of the ancestral Wuhan-Hu-1 strain of SARS-CoV-2. (news-medical.net)
  • The gene encodes two different protein by virtue of alternate, JMV 390-1 in-frame, start codons [16]. (ees2010prague.org)
  • RNA polymerase was shown to bind to the new promoter motif using a DNA-binding protein assay and proteomics enabled the discovery of four candidates to potentially function directly in control of transcription of the WLP and other key genes of C 1 fixation metabolism. (biorxiv.org)
  • Next, in vivo experiments showed that a TetR-family transcriptional regulator (CAETHG_0459) and the housekeeping sigma factor (σ A ) activate expression of a reporter protein (GFP) in-frame with the new promoter motif from a fusion vector in E. coli . (biorxiv.org)
  • Lastly, a protein-protein interaction assay with the RNA polymerase (RNAP) shows that CAETHG_0459 directly binds to the RNAP. (biorxiv.org)
  • The Myb proteins interact with a highly conserved multi-protein complex called the MuvB core. (stanford.edu)
  • Freiburg: fibrillin-1 waste DNA as a second role of fluctuation-dissipation protein. (erik-mill.de)
  • Bone morphogenetic protein (BMP) 2 belongs to the transforming growth factor β (TGFβ) superfamily of cytokines and growth factors. (ualg.pt)
  • protein_coding" "AAC73596","tesA","Escherichia coli","acyl-CoA thioesterase 1 and protease I and lysophospholipase L1 [Ensembl]. (ntu.edu.sg)
  • RNA-binding protein;RNA degradosome binding protein [Ensembl]. (ntu.edu.sg)
  • PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
  • Acts by binding to 50S ribosomal subunit of susceptible microorganisms and blocks dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. (medscape.com)
  • expressed in middle/late meiosis,IV" YDR525W 1 5 7 YDR525W "Ydr525wp,IV" YDR526C 1 5 8 YDR526C "Ydr526cp,IV" YER187W 1 5 9 YER187W "similar to killer toxin,V" YER188W 1 5 10 YER188W "Yer188wp,V" YER190W 1 5 11 YER190W "Yrf1-2p,V" YFL002C 1 5 12 YFL002C "ATP-dependent RNA helicase,VI" YFL002W-B 1 5 13 YFL002W-B "TyA gag protein. (davidson.edu)
  • contains a zinc finger,XV" YOL091W 1 15 16 YOL091W "involved in sporulation,XV" YOL103W-B 1 15 17 YOL103W-B "TyB Gag-Pol protein. (davidson.edu)
  • XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)
  • While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors to communicate with essentially every organ system in the body. (diabetesjournals.org)
  • Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)
  • The inhibitory effect of resveratrol on poxviruses is independent of VACV N1 protein, a potential resveratrol binding target. (researchgate.net)
Polymerase3
  • Which of the following is NOT a component of the bacterial RNA polymerase core enzyme? (paperforpay.com)
  • In the experiment to study the effect of temperature change on RNA polymerase binding to DNA, we found that as the temperature is _______, the binding of RNA polymerase to DNA decreases. (paperforpay.com)
  • Because _______ temperatures promote DNA melting and encourage RNA polymerase binding. (paperforpay.com)
Proteins17
  • Gel-shift assays sublocalized two cis-regulatory regions, nt -101 to -123 and nt -121 to -145, which specifically bind CT26 nuclear proteins. (duke.edu)
  • Subsequent supershift and chromatin immunoprecipitation assays confirmed the corresponding nuclear proteins to be Ets-1 and Runx2. (duke.edu)
  • Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (lookformedical.com)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • Many DNA-binding proteins show co-localization in ChIP-Seq data without presence of the corresponding DNA motifs. (sdbonline.org)
  • Recently, eukaryotic transcriptional activators and coactivators (both positive and negative) resembling core and linker histone proteins have been discovered. (embl-heidelberg.de)
  • BMs also harbor matricellular proteins, growth factors, and proteases ( 1 ). (science.org)
  • 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). (mcw.edu)
  • The proteins encoded by Myb genes bind to DNA and regulate the expression of other genes that control cell division, differentiation, and cell death. (stanford.edu)
  • The same complex also interacts with proteins of the Rb tumor suppressor family and the E2F transcription factor family. (stanford.edu)
  • [ 7 ] Tropomyosins are a family of actin-binding coiled-coil proteins that help to regulate calcium-dependent muscle contraction. (medscape.com)
  • ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
  • Like Ras, ARFs are active in their GTP-bound form, and their duration of activity is controlled by GTPase-activating proteins (GAPs), which assist ARFs in hydrolyzing GTP to GDP. (embl.de)
  • arrests bacterial growth by binding to one or more penicillin-binding proteins. (medscape.com)
  • Binds to penicillin-binding proteins and inhibits final transpeptidation step of peptidoglycan synthesis, resulting in cell wall death. (medscape.com)
Heterodimeric transcription2
  • Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. (anticorps-enligne.fr)
  • Under well-oxygenated conditions this complex binds directly to the alpha subunit of the heterodimeric transcription element HIF (hypoxia-inducible element) and focuses on it for proteasomal degradation. (ees2010prague.org)
RUNX27
  • Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. (duke.edu)
  • Ets-1 and Runx2 are critical transcriptional regulators of OPN expression in CT26 colorectal cancer cells. (duke.edu)
  • Consistent with the presence of multiple Runx2 binding sites, the binding of Runx2 to the aromatase promoter was demonstrated in vitro and confirmed in vivo by chromatin immunoprecipitation assays. (umassmed.edu)
  • Consistently, beta-galactosidase staining in axial skeleton of -3 kb-Runx2-P1-LacZ transgenic mice was positive, but that of all skeletal tissues of -1 kb-Runx2-P1-LacZ transgenic mice was negative. (nbrp.jp)
  • To identify upstream regulators of the Runx2-P1 promoter, we screened 100 transcription factors using Runx2-P1-luciferase reporter constructs in NIH3T3 fibroblasts and HeLa cells. (nbrp.jp)
  • An electrophoretic mobility shift assay and chromatin immunoprecipitation assay confirmed the binding of HIF2A to the Runx2-P1 promoter in vitro and in vivo, respectively. (nbrp.jp)
  • Collectively, these results suggest that the region between -3 kb and -1 kb is required for the minimal skeletal tissue-specific expression of Runx2, and that the region between -155 bp and -75 bp is important for its basal transcription, which may be in part mediated by HIF2A in bone tissues. (nbrp.jp)
Mitochondrial1
  • RTA items from the follicle of the mitochondrial mammalian activities to decrease been binding from subset, connecting to recessive HCO3- lumen and wide lipoprotein. (erik-mill.de)
Genes8
  • However, the precise mechanisms by which these factors interact to form transcriptional networks, as well as the identity of the genes downstream of these regulatory cascades, remain largely unknown. (ox.ac.uk)
  • Bioinformatics analysis resulted in the identification of 9 candidate Scl target transcription factor genes, including Runx1 and Runx3. (ox.ac.uk)
  • 18 hub genes were selected in PPI network, among which there were 6 core genes evaluated by DAVID. (researchsquare.com)
  • Condensation of DNA into chromatin by the core (H2A, H2B, H3, H4) and linker (H1, H5) histones effectively represses transcription initiation from the promoters of genes that have been packaged. (embl-heidelberg.de)
  • Four core functional pathways were identified to enrich the up-regulated genes and were significantly associated with a worse prognosis in HNC patients, as the modulation of cellular focal adhesion, the PI3K-Akt signaling pathway, the HIF-1 signaling pathway, and the regulation of stem cell pluripotency. (biomedcentral.com)
  • Total of 16 up-regulated genes in the 4 core pathways were defined, and 11 over-expressed molecules showed correlated with poor survival (TCGA-HNSCC dataset, n = 283). (biomedcentral.com)
  • Most PWD F4-positive ETEC are of the serogroup O149, whereas F18-positive ETEC belong to many serogroups, including O138, O139, O141, O147, and O157, because the F4 or F18 fimbriae gene cluster and enterotoxin genes are encoded on conjugative plasmids that result in their spread ( 1 ). (cdc.gov)
  • [1] The well-known cancer susceptibility genes BRCA1 and BRCA2 are also examples of FA genes (FANCS and FANCD1 respectively), and biallelic mutation of any of the two genes usually results in an embryonically lethal outcome, and should the proband come to term, experience a severe form of Fanconi anemia. (wikipedia.org)
TRNA3
  • A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. (cansar.ai)
  • We present a model for controlled nucleotide exchange and initiator tRNA binding to the eIF2/eIF2B complex. (rcsb.org)
  • Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis. (colorado.edu)
Runx14
  • T-bet interacted with the transcription factor Runx1, and this interaction blocked Runx1-mediated transactivation of Rorc. (nih.gov)
  • Transcription factors such as Scl/Tal1, Lmo2, and Runx1 are essential for the development of hematopoietic stem cells (HSCs). (ox.ac.uk)
  • Furthermore, binding of an Scl-Lmo2-Gata2 complex was demonstrated to occur on the regions flanking the conserved E-boxes of the Runx1 loci and was shown to transactivate the Runx1 element. (ox.ac.uk)
  • CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. (zfin.org)
Runt domain1
  • It contains a highly conserved DNA -binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION . (bvsalud.org)
Ligand3
  • The Alliance for Cellular Signaling (AfCS) murine B cell single ligand screen with 33 ligands utilizing Agilent microarrays was analyzed for its effects on initiation factor gene expression. (escholarship.org)
  • 2014). The initiation of necroptosis can be stimulated by the same death ligands that activate extrinsic apoptotic signaling pathway, such as tumor necrosis factor (TNF) alpha, Fas ligand (FasL), and TRAIL (TNF-related apoptosis-inducing ligand) or toll like receptors 3 and 4 ligands (Holler N et al. (wikipathways.org)
  • wound 1 is the even 28S tBID of subunit ligand to depend I variety. (evakoch.com)
Phosphorylation2
  • eIF2, which is inactivated upon phosphorylation of subunit 1 by alpha kinases 1-4, was seen to have discordant regulation of subunits and differing levels of kinase gene expression for different ligands, indicating a high degree of variability in global translation. (escholarship.org)
  • binding family is rRNA-encoding phosphorylation transcription and frequency product through the practice of the R-RasGAP a004754 xenobiotic to ovarian or through the arginine of RhoA. (evakoch.com)
Putative1
  • putative DNA-binding transcriptional regulator [Ensembl]. (ntu.edu.sg)
Gene Expression3
  • A comprehensive set of core promoter motifs are detected at boundaries, including the newly discovered M1BP motif, and motifs which have been associated to housekeeping gene expression. (sdbonline.org)
  • We also showed that although C. elegans (nematode worm) lost its animal-type Myb gene hundreds of millions of years ago, the Drosophila Myb "key" still binds to and can open the highly conserved worm MuvB "lock" that represses gene expression. (stanford.edu)
  • 1, 6, 7 Currently, array technology is usually most useful in establishing broad patterns of gene expression and in screening for differential gene expression. (irjs.info)
Enhancer factor1
  • Although to a lesser extent, myocyte enhancer factor 2C (MEF2C) had also a negative effect on the regulation of BMP2 gene transcription, when associated with SRY (sex determining region Y)-box 9 (SOX9b). (ualg.pt)
Transcription Factors3
  • Histone-like transcription factors in eukaryotes. (embl-heidelberg.de)
  • Substantial progress has been made on structural and mechanistic studies of histones and histone-like transcription factors. (embl-heidelberg.de)
  • In silico analysis of seabream BMP2 promoter revealed several binding sites for bone and cartilage related transcription factors (TFs) and their functionality was evaluated using promoter-luciferase constructions and TF-expressing vectors. (ualg.pt)
Complexes2
  • Eukaryotic Translation Initiation is governed by large initiation factor complexes, whose subunits are regulated in a largely discordant fashion. (escholarship.org)
  • Fail-safe control of translation initiation by dissociation of eIF2 alpha phosphorylated ternary complexes. (rcsb.org)
Regulate4
  • Overactive responses by interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are tightly linked to the development of autoimmunity, yet the factors that negatively regulate the differentiation of this lineage remain unknown. (nih.gov)
  • Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. (cansar.ai)
  • As there are many different ECMs, it is unknown whether many of these components bind to function within or regulate BMs. (science.org)
  • Runt-related transcription factor 3 (RUNX3) was shown to negatively regulate BMP2 transcription and combination with the core binding factor β (CBFβ) further reduced transcriptional activity of the promoter. (ualg.pt)
Motif4
  • A proposed mechanism, based on the extrusion of DNA by cohesin, suggests that the DNA-binding motif of CTCF and its orientation determine the start and end of the loop. (sdbonline.org)
  • Motif calling was performed at boundaries, validating the presence of known insulators, along with M1BP motif, which recently has also been shown to be associated to boundaries and core promoter motif 6 and motif 8, which have not been associated to boundaries before. (sdbonline.org)
  • 2009). Within the necrosome RIPK1 and RIPK3 bind to each other through their RIP homotypic interaction motif (RHIM) domains. (wikipathways.org)
  • The ARF-GAP domain comprises a central three-stranded beta-sheet flanked by five alpha-helices, with a Zn(2+) ion coordinated by the four cysteines of the cysteine-rich motif. (embl.de)
Regulatory1
  • The structures reveal that eIF2 undergoes large rearrangements to promote binding of eIF2α to the regulatory core of eIF2B comprised of the eIF2B alpha, beta and delta subunits. (rcsb.org)
Complex6
  • Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (cansar.ai)
  • eIF3, a large complex with at least 10 subunits, is seen to have discordant regulation of its subunits as well, even for a conserved 'core' complex, attesting to their dual functions in cellular machinery. (escholarship.org)
  • eIF4, a complex consisting of 3 subunits with multiple subunit isoforms, was seen to express only eIF4G isoform 3 in murine B cells. (escholarship.org)
  • Specifically, pVHL is the substrate acknowledgement subunit of a ubiquitin ligase complex that also contains elongin B, elongin C, Cul2, and Rbx1 [16]. (ees2010prague.org)
  • In subunit, complex can convert been with timing or was to its physiological cis-Golgi, the two Epithelial collagens in which it suggests expressed from the sugar( Yuen et al. (erik-mill.de)
  • Heritability estimates of complex traits such as loneliness may change across the lifespan, however, as the frequency, duration, and range of exposure to environmental influences accrues, or as the expression of genetic factors changes. (cdc.gov)
Domain6
  • Phage integrase family, Arm DNA-binding domain [Interproscan]. (ntu.edu.sg)
  • HTH-like domain, Integrase core domain [Interproscan]. (ntu.edu.sg)
  • pVHL contains two hot-spots for missense mutations, called the alpha domain name and the beta domain name. (ees2010prague.org)
  • S1 RNA binding domain, Ribonuclease E/G family, Polyribonucleotide phosphorylase C terminal [Interproscan]. (ntu.edu.sg)
  • the E-value for the ANK domain shown below is 7.59e-1. (embl.de)
  • The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. (embl.de)
Substrate1
  • Insulin Receptor Substrate 1 (IRS-1). (embl.de)
Cells8
  • The step-down pattern in promoter activity between -3 kb and -1 kb was observed only in osseous cells. (nbrp.jp)
  • Which sigma factors is essential for general transcription in exponentially growing E. coli cells? (paperforpay.com)
  • The high resolution structure of the nucleosome core particle of chromatin reveals the form of DNA that is predominant in living cells and offers a wealth of information on DNA binding and bending by the histone octamer. (embl-heidelberg.de)
  • Likewise, these cells had polyfunctional cytokine-producing cells dominated by those producing interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and interleukin 2 (IL-2). (news-medical.net)
  • One study has identified the estrogen receptor alpha (ER-α) gene (ESR1) as a target induced by both IFNα and IFNγ in distinct cell types, including splenic cells, from lupus mice ( 24 ). (frontiersin.org)
  • methods in SLC4A4 can eliminate CD28 glycolytic cheap infectious hydrophobic digestion with healthy cells and CBL-mediated network( family), a partial NEK7 Binding apoptosis elucidated by biological -, additional available synaptic calcification, autosomal collagen, antimicrobial stimulation, channels and cholestasis. (erik-mill.de)
  • The outcome of the ensuing battle will determine whether the infection will remain locally limited within the engulfing cells of the innate immune system, or will continue to spread, causing the individual to become a clinically active TB patient [ 1 , 6 , 7 , 8 ]. (intechopen.com)
  • These toxins bind to specific receptors of the intestinal epithelial cells and cause secretion of water and electrolytes into the intestinal lumen. (cdc.gov)
Estrogen1
  • This narrative review provides an update on the impact of vitamin D on hormone receptors, notably estrogen receptor subunits, and gives insights on possible therapeutic interventions to overcome breast cancer. (qualitycounts.com)
Assays1
  • Finally, the team used microneutralization and human angiotensin-converting enzyme 2 (hACE2) binding inhibition assays to analyze anti-S antibody titers. (news-medical.net)
Tumor1
  • Tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) is an interesting costimulatory molecule associated with T lymphocyte activation, and it mainly exerts its biological effects by binding to its receptors herpesvirus invasion mediator (HVEM) and lymphotoxin-ß receptor. (bvsalud.org)
Biological1
  • Both subclones were grown as monolayers on -irradiated (5000 rads) Swiss Mouse 3T3 fibroblast feeder layers in INCB018424 biological activity F-medium (3:1 F12 and Dulbeccos modified Eagles medium) with 5% fetal bovine serum (FBS). (irjs.info)
DsDNA2
  • Here we report our observations, derived from diverse imaging methods on genome internalization of the large dsDNA Paramecium bursaria chlorella virus-1 (PBCV-1). (weizmann.ac.il)
  • Our studies reveal that early infection stages of this eukaryotic-infecting virus occurs by a bacteriophage-like pathway, whereby PBCV-1 generates a hole in the host cell wall and ejects its dsDNA genome in a linear, base-pair-by-base-pair process, through a membrane tunnel generated by the fusion of the virus internal membrane with the host membrane. (weizmann.ac.il)
Cartilage1
  • Effects of FGF-2 and OP-1 in vitro on donor source cartilage for auricular reconstruction tissue engineering. (omeka.net)
Molecule1
  • Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)
Glycogenin1
  • Glycogen phenotype binds tightly converted by the cycle of glycogenin( GYG) to determine oligo( 1,4)-alpha-D-glucosyl GYG. (evakoch.com)
Zinc1
  • Binds these RNAs through its zinc fingers. (cansar.ai)
HUMAN4
  • Previous studies have indicated that ER stress could inhibit the replication of human coronaviruses, and some human coronaviruses in turn could suppress ER stress-related factors. (bvsalud.org)
  • Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. (cansar.ai)
  • One important factor is the introduction of the human immunodeficiency virus (HIV) into areas and populations already having a high TB incidence [ 5 ], the resulting double infections having a disastrous effect. (intechopen.com)
  • During this talk, I will tell two such stories: 1) Structural variations in the human genome originate from different mechanisms related to DNA repair, replication, and retro-transposition. (jcbose.ac.in)
Enzyme2
  • Chlorovirus PBCV-1 infects its host, Chlorella variabilis NC64A by specifically binding to and degrading the cell wall of the host at the point of contact by a virus-packaged enzyme(s). (weizmann.ac.il)
  • 1, 2, 3 The performance of the reverse transcription (RT) response may be suffering from the enzyme, primers, nucleotides, and RNA secondary framework. (irjs.info)
EIF22
  • To provide insight into the mechanism of translational control we have determined the structures of eIF2 both in phosphorylated and unphosphorylated forms bound with its nucleotide exchange factor eIF2B by electron cryomicroscopy. (rcsb.org)
  • Only minor differences are observed between eIF2 and eIF2αP binding to eIF2B, suggesting that the higher affinity of eIF2αP for eIF2B drives translational control. (rcsb.org)
Inhibitor1
  • The purified inhibitor was determined to be a slow- and tight-binding inhibitor of bovine CPA (Ki = 1.1·× 10-8 mol/L) and porcine CPB (Ki = 8.15·× 10-8 mol/L) and was not able to inhibit proteases from other mechanistic classes. (bvsalud.org)
Beta2
  • Factor de transcripción que dimeriza con la SUBUNIDAD BETA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL para formar el factor de unión al sitio principal. (bvsalud.org)
  • A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. (bvsalud.org)
Homolog1
  • Finally, v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1) was able to slightly enhance BMP2 transcription. (ualg.pt)
Interferon1
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with pathogenic autoantibodies and increased levels of type 1 interferon (IFNs) and their signaling molecules both in mice and in humans ( 1 - 10 ). (frontiersin.org)
Bone1
  • Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (wikipedia.org)
Virion2
  • The core is disassembled soon after virion entry (By similarity). (cansar.ai)
  • However, PBCV-1 does not use any of the five previously characterized virus-encoded polysaccharide degrading enzymes to digest the Chlorella host cell wall during virus entry because none of the enzymes are packaged in the virion. (weizmann.ac.il)
Family2
  • The HIF Transcription Factor There are three HIF family members (HIF1, HIF2, HIF3) and two HIF family members (HIF1 and HIF2)[22]. (ees2010prague.org)
  • Some other related factors, such as adaptability and influence of the peer groups, abandoning school by siblings, and extra responsibility at home and a joint family system, are also some notable factors that significantly affect the dropout rate in schools Malakand District of KP province. (preprints.org)
Cancers1
  • Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs - Phytother Res 2022 Jun 1 - 'The lack of reliable drugs is a therapeutic challenge of advanced breast cancers (ABCs). (qualitycounts.com)
Transcriptional activator1
  • Three-dimensional structures solved include the core histone octamer, an archael histone homodimer, two core histone-like subunits of transcription factor IID, a linker histone, and a linker histone-like transcriptional activator. (embl-heidelberg.de)
Membrane1
  • Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (cansar.ai)
Histone1
  • The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry. (embl-heidelberg.de)