Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
Granulomatous disorders affecting one or more sites in the respiratory tract.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.
A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.
So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)

Cord formation in MB/BacT medium is a reliable criterion for presumptive identification of Mycobacterium tuberculosis complex in laboratories with high prevalence of M. tuberculosis. (1/135)

We evaluated cord formation in MB/BacT broth as a rapid method for presumptive identification of the Mycobacterium tuberculosis complex. Kinyoun acid-fast-stained smears from 370 positive MB/BacT bottles were examined for the presence of serpentine cording. The smears were examined independently by two observers. Observer 1 (the supervisor of the mycobacteriology laboratory) examined all of the smears while observer 2 (a clinical microbiologist not familiar with acid-fast bacillus [AFB] microscopy) examined 148 randomly chosen smears that were read by observer 1 without knowledge of which smear was which. The sensitivity, specificity, and positive and negative predictive values of cording for the presumptive identification of M. tuberculosis read by observer 1 were 88.2, 97.4, 99.2, and 69.7%, respectively. These values were reported at 90.6, 52.3, 82.8, and 69. 7%, respectively, by observer 2. Our laboratory prevalence of M. tuberculosis among positive cultures was 78% during the time this study was conducted. At the time of positive signal of the MB/BacT bottles, the broth of the bottles had sufficient cell mass to allow for observation of the presence or absence of serpentine cording. The presence of cords in MB/BacT broth is a reliable criterion for rapid, predictive identification of the M. tuberculosis complex for laboratories with a high proportion of the M. tuberculosis complex when the smears are examined by a microbiologist who has experience with AFB staining.  (+info)

Trehalose 6,6'-dimycolate (Cord factor) enhances neovascularization through vascular endothelial growth factor production by neutrophils and macrophages. (2/135)

Trehalose 6,6'-dimycolate (TDM) plays important roles in the development of granulomatous inflammation during infection with Mycobacterium spp., Rhodococcus spp., etc. To reveal the augmenting effect of TDM on vascular endothelial growth factor (VEGF) production and neovascularization, we investigated murine granulomatous tissue air pouches induced by Rhodococcus sp. strain 4306 TDM dissolved in Freund's incomplete adjuvant (FIA), comparing them to pouches treated with FIA alone. Histologically, granulomatous tissue and new vessel formation, which reached a maximum at day 7, was greatly enhanced by treatment with TDM. At day 1, VEGF-positive neutrophils accumulated in the pouch wall with frequency of 95% of total infiltrating cells, adhering to TDM-containing micelles. By day 3, granulomatous tissue and new vessels started to develop, and VEGF-positive macrophages appeared in a small number and gradually increased in number thereafter. The pouch contents of VEGF, interleukin-1beta, tumor necrosis factor alpha, and transforming growth factor beta were significantly elevated in TDM-treated pouches, with peaks at days 1, 0.5, 1, and 3, respectively, compared to those of control pouches, while that of basic fibroblast growth factor showed no significant increase. Treatment with anti-VEGF antibody inhibited TDM-induced granulomatous tissue formation and neovascularization, and administration of recombinant VEGF into pouches treated with FIA alone induced neovascularization comparable to that in the TDM-treated pouches. Incubation of neutrophils and macrophages on TDM-coated plastic dishes increased the VEGF release. The present results indicate that TDM augments VEGF production by neutrophils and macrophages and induces neovascularization in the granulomatous tissue.  (+info)

Assessment of morphology for rapid presumptive identification of Mycobacterium tuberculosis and Mycobacterium kansasii. (3/135)

Mycobacterium tuberculosis often exhibits serpentine cording when grown in liquid medium, whereas Mycobacterium kansasii can be larger and cross-barred. We assessed the use of these morphologic characteristics as a cost-effective method for rapid presumptive identification of isolates from BACTEC bottles. Without specific training, using the Kinyoun acid-fast stain, definitive cording was found in 237 of 373 specimens positive for M. tuberculosis (64%) and cross-barring was recognized within 63 of 76 (83%) of the specimens positive for M. kansasii, giving sensitivities specificities, positive predictive values, and negative predictive values of 63.5, 96, 92, and 79%, respectively, for M. tuberculosis and 83, 95, 59, and 98%, respectively, for M. kansasii. With training and experience, these results improved to 74.5, 98, 96, and 84% and 93, 98, 79, and 98%, respectively. The major improvements were in distinguishing the pseudocording, or loose aggregation of Mycobacterium avium complex from M. tuberculosis and the long beaded forms of Mycobacterium gordonae from M. kansasii. Mycobacterium asiaticum and Mycobacterium szulgai, which rarely occur, are genetically related to M. kansasii and morphologically difficult to distinguish. In defined circumstances, serpentine cording and cross-barring can be used for rapid presumptive identification of M. tuberculosis and M. kansasii, respectively, and as guides for initial probe selection to reduce costs.  (+info)

In vivo administration of mycobacterial cord factor (Trehalose 6, 6'-dimycolate) can induce lung and liver granulomas and thymic atrophy in rabbits. (4/135)

Trehalose 6,6'-dimycolate (TDM) is a cell surface molecule of Mycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the liver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contrast, sulfolipid (2,3,6, 6'-tetraacyl trehalose 2'-sulfate) induced neither toxicity, nor granuloma formation, nor atrophy of the thymus and spleen. In rabbits the histopathological changes were more dramatic than in mice. The rabbit model may be more sensitive and may provide more information on the beneficial or pathological effects of TDM.  (+info)

How to establish a lasting relationship with your host: lessons learned from Mycobacterium spp. (5/135)

Mycobacterium spp. enjoy an intracellular lifestyle that is fatal to most microorganisms. Bacilli persist and multiply within mononuclear phagocytes in the face of defences ranging from toxic oxygen and nitrogen radicals, acidic proteases and bactericidal peptides. Uptake of Mycobacterium by phagocytes results in the de novo formation of a phagosome, which is manipulated by the pathogen to accommodate its needs for intracellular survival and replication. The present review describes the intracellular compartment occupied by Mycobacterium spp. and presents current ideas on how mycobacteria may establish this niche, placing special emphasis on the involvement of mycobacterial cell wall lipids.  (+info)

Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces corneal angiogenesis in rats. (6/135)

Neovascularization or angiogenesis is required for the progression of chronic inflammation. The mechanism of inflammatory neovascularization in tuberculosis remains unknown. Trehalose 6, 6'-dimycolate (TDM) purified from Mycobacterium tuberculosis was injected into rat corneas. TDM challenge provoked a local granulomatous response in association with neovascularization. Neovascularization was seen within a few days after the challenge, with the extent of neovascularization being dose dependent, although granulomatous lesions developed 14 days after the challenge. Cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), IL-1beta, and vascular endothelial growth factor (VEGF), were found in lesions at the early stage (within a few days after the challenge) and were detectable until day 21. Neovascularization was inhibited substantially by neutralizing antibodies to VEGF and IL-8 but not IL-1beta. Treatment with anti-TNF-alpha antibodies resulted in partial inhibition. TDM possesses pleiotropic activities, and the cytokine network plays an important role in the process of neovascularization.  (+info)

New diagnostic approach for ocular tuberculosis by ELISA using the cord factor as antigen. (7/135)

BACKGROUND/AIMS: Diagnosis of ocular tuberculosis is difficult, particularly the retinal vasculitis type, because most cases occur without concurrent active pulmonary tuberculosis. Recently, it has been reported that detection of antibodies against purified cord factor (trehalose-6,6'-dimycolate, TDM), the best studied, most antigenic, and most abundant cell wall component of tubercule bacilli, is very useful for rapid serodiagnosis of pulmonary tuberculosis. In this study, an attempt was made to evaluate whether the detection of anticord factor antibody is also useful for diagnosis of ocular tuberculosis and the necessity of antituberculous therapy for tuberculous retinochoroiditis was discussed. METHODS: Cases consisted of 15 patients with uveitis and retinal vasculitis, nine patients with presumed ocular tuberculosis, three patients with sarcoidosis, and three patients with Behcet's disease. IgG antibodies against purified cord factor prepared from Mycobacterium tuberculosis H37Rv were detected by enzyme linked immunosorbent assay. RESULTS: All cases of clinically presumed ocular tuberculosis were positive, whereas all of the cases of sarcoidosis or Behcet's disease were negative for anticord factor antibodies. When the anticord factor antibody titres were compared on the basis of the presence or absence of previous antituberculosis chemotherapy, the mean anticord factor antibody titre of the untreated group showed a tendency to be higher than in the treated group, but not significantly (p=0.07). CONCLUSIONS: The detection of anticord factor antibody may be useful to support the diagnosis of ocular tuberculosis. Additionally, a positive result for anticord factor antibody may indicate that tubercule bacilli are present in some organ(s) of the patient even in the absence of active systemic disease.  (+info)

Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in mice. (8/135)

Granulomatous inflammation is characterized morphologically by a compact organized collection of macrophages and their derivatives. It is classified as either a hypersensitivity type or a foreign-body type. Lipid components of the Mycobacterium tuberculosis cell wall participate in the pathogenesis of infection. Strains of M. tuberculosis have cord factor (trehalose 6,6'-dimycolate [TDM]) on their surface. To clarify host responses to TDM, including immunogenicity and pathogenicity, we have analyzed the footpad reaction, histopathology, and cytokine profiles of experimental granulomatous lesions in immunized and unimmunized mice challenged with TDM. In the present study, we have demonstrated for the first time that TDM can induce both foreign-body-type (nonimmune) and hypersensitivity-type (immune) granulomas by acting as a nonspecific irritant and T-cell-dependent antigen. Immunized mice challenged with TDM developed more severe lesions than unimmunized mice. At the active lesion, we found monocyte chemotactic, proinflammatory, and immunoregulatory cytokines. The level was enhanced in immunized mice challenged with TDM. This result implies that both nonimmune and immune mechanisms participate in granulomatous inflammation induced by mycobacterial infection. Taken together with a previous report, this study shows that TDM is a pleiotropic molecule against the host and plays an important role in the pathogenesis of tuberculosis.  (+info)

The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM and TDB. The Syk-coupling adapter protein FcRg was essential for macrophage activation and Th17 adjuvanticity. The FcRg-associated C-type lectin receptor Mincle was expressed in macrophages and upregulated by TDM and TDB. Recombinant Mincle-Fc fusion protein specifically bound to the glycolipids. Genetic ablation of Mincle abolished TDM/TDB-induced macrophage activation and induction of T cell immune responses to a tuberculosis subunit vaccine. Macrophages lacking Mincle or FcRg were impaired in the inflammatory response to Mycobacterium bovis bacillus Calmette- Gue䲩n. These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 ...
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. A cord factor molecule is composed of a trehalose sugar, a disaccharide, that is esterified to two mycolic acid residues. One of the two mycolic acid residues is attached to the sixth carbon of one monosaccharide, while the other mycolic acid residue is attached to the sixth carbon of the other monosaccharide. Therefore, cord factor is also named trehalose-6,6-dimycolate. The carbon chain of the mycolic acid residues vary in ...
Shop Trehalose monomycolate exporter ELISA Kit, Recombinant Protein and Trehalose monomycolate exporter Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The structure of cord factor was studied in several strains of Mycobacterium simiae, including habana TMC 5135, considered as highly immunogenic in experimental tuberculosis and leprosy. The mycolic acids liberated from cord factor were identified in all cases as α′-, α- and keto-mycolates. According to the general NMR and MS data, α′-mycolates were mono-unsaturated and contained from 64 to 68 carbon atoms, whereas α-mycolates mainly presented two 2,3-disubstituted cyclopropane rings and a chain length of 80-91 carbon atoms; keto-mycolates mostly contained one cyclopropane ring and 85-91 carbon atoms. Taking into account the 1H-NMR results, strains varied in the ratio of the different mycolates, and the high levels of keto-mycolates found in the cord factors of TMC 5135 and ATCC 25275T stood out. Notably, MS revealed that the odd carbon number series of α-mycolates (C87-C89) predominated in the cord factor of TMC 5135, in contrast to the remaining studied strains, in which the even (C84-C86)
article{8174192, author = {Tima, Hermann Giresse and Al Dulayymi, Jumaa Raheem and Denis, Olivier and Lehebel, Pauline and Baols, Klarah Sherzad and Mohammed, Mohsin Omar and LHomme, Laurent and Sahb, Mohaned Mohammed and Potemberg, Georges and Legrand, Sylvie and Lang, Roland and Beyaert, Rudi and Piette, Jacques and Baird, Mark Stephen and Huygen, Kris and Romano, Marta}, issn = {1662-811X}, journal = {JOURNAL OF INNATE IMMUNITY}, keyword = {Mycobacterium tuberculosis,Glycolipids,Trehalose dimycolate,Trehalose monomycolate,Glucose monomycolate,Arabinose monomycolate,Inflammasome,Adjuvant,CORD FACTOR,ACIDS,MICE,RECEPTOR,MINCLE,ACTIVATION,CYCLOPROPANATION,RECOGNITION,MACROPHAGES,MONOESTERS}, language = {eng}, number = {2}, pages = {162--180}, title = {Inflammatory properties and adjuvant potential of synthetic glycolipids homologous to mycolate esters of the cell wall of Mycobacterium tuberculosis}, url = {http://dx.doi.org/10.1159/000450955}, volume = {9}, year = {2017 ...
Mycobacterial lipids have long been known to modulate the function of a variety of cells of the innate immune system. Here, we report the extraction and characterisation of polar and apolar free lipids from Mycobacterium bovis AF 2122/97 and identify the major lipids present in these fractions. Lipids found included trehalose dimycolate (TDM) and trehalose monomycolate (TMM), the apolar phthiocerol dimycocersates (PDIMs), triacyl glycerol (TAG), pentacyl trehalose (PAT), phenolic glycolipid (PGL), and mono-mycolyl glycerol (MMG). Polar lipids identified included glucose monomycolate (GMM), diphosphatidyl glycerol (DPG), phenylethanolamine (PE) and a range of mono- and di-acylated phosphatidyl inositol mannosides (PIMs). These lipid fractions are capable of altering the cytokine profile produced by fresh and cultured bovine monocytes as well as monocyte derived dendritic cells. Significant increases in the production of IL-10, IL-12, MIP-1β, TNFα and IL-6 were seen after exposure of antigen ...
Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S. 2009. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.. J Exp Med. 206(13):2879-88. ...
Werninghaus K, Babiak A, Gross O, Holscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R. 2009. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med 206: 89- ...
Carlétti D, Fonseca DM da, Gembre AF, Masson AP, Campos LW, Leite LCC, Pires AR, Lannes-Vieira J, Silva CL, Bonato VLD, Horn C. A single dose of a DNA vaccine encoding Apa coencapsulated with 6,6-trehalose dimycolate in microspheres confers long-term protection against Tuberculosis in Mycobacterium bovis BCG-primed mice [Internet]. Clinical and Vaccine Immunology. 2013 ; 20( 8): 1162-1169.Available from: http://dx.doi.org/10.1128/CVI.00148- ...
We use the fact that when there is a sufficient relationship between the plasma level of the drug and its clinical effect, it is then useful to measure this level. If such a relationship does not exit, TDM is of little or no value. Based on this fact, the TDM will be of maximal benefit when:. ...
Complete information for TMEM54 gene (Protein Coding), Transmembrane Protein 54, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for TMEM78 gene (Protein Coding), Transmembrane Protein 78, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Expertise Lab. : failure analyses, production, qualification. Warpage measurements of component, PCB, board, full system, during reflow or cycle thermal stress. Deformation, Displacement fields, Dilatation and thermal expansion, CTE.
TDM - IPFA 2010 Proceedings Topography and Deformation Measurement and FE Modeling applied to substrate-mounted large area wafer-level packages (including stacked dice and TSVs) ...
Published studies indicate that mycobacterial lipid antigens may stimulate CD1-restricted T cells. However, the pool of studied mycobacterial antigenic lipids is small compared with the diversity of the lipid components of the M. tuberculosis envelope. So far, only three classes of molecules were shown to stimulate CD1b-restricted T cells: free mycolic acids (13), mycoloyl glycolipids such as glucose monomycolate (17), and phosphoglycolipids represented by lipoarabinomannan (19), lipomannan (19), and PIM (20). These molecules are commonly present in the envelope of both virulent and nonvirulent mycobacteria. Their immunogenicity during infection with virulent or avirulent strains has not been compared.. In these studies we have characterized the structure of a novel mycobacterial glycolipid, a diacylated sulfoglycolipid (Ac2SGL), presented by CD1b on the cell surface of M. tuberculosis-infected APCs. This antigen stimulates bactericidal CD8+ T cells and evokes strong responses in healthy PPD+ ...
The purpose of this study was to establish optimal molar glycerol to glucose ratio for enhanced biosurfactant synthesis by the cultivation of Nocardia vacсinii ІMV В-7405 on a mixture of energetically nonequivalent substrates (glucose and glycerol). Based on theoretical calculations of the energy requirements for biomass production and the synthesis of surface-active trehalose monomycolates on the energy-deficient substrate (glycerol), the concentration of the energy-excessive substrate (glucose), which increased the efficiency of the substrate carbon conversion to biosurfactant, was determined. It was found that the synthesis of extracellular biosurfactant on a mixture of glucose and glycerol at molar ratio of 1.0:2.5 increased 2.0-2.3-fold compared to that on corresponding monosubstrates. The increased level of biosurfactant on the mixed substrate is determined by intensification of surface-active trehalose monomycolate synthesis, confirmed by 1.2-5.7-fold increase in activity of the ...
0146]Further exemplary adjuvants to enhance effectiveness of the composition include, but are not limited to: (1) oil-in-water emulsion formulations (with or without other specific immunostimulating agents such as muramyl peptides (see below) or bacterial cell wall components), such as for example (a) MF59® (W090/14837; Chapter 10 in Vaccine design: the subunit and adjuvant approach, eds. Powell & Newman, Plenum Press 1995), containing 5% Squalene, 0.5% Tween 80, and 0.5% Span 85 (optionally containing MTP-PE) formulated into submicron particles using a microfluidizer, (b) SAF, containing 10% Squalane, 0.4% Tween 80, 5% pluronic-blocked polymer L121, and thr-MDP either microfluidized into a submicron emulsion or vortexed to generate a larger particle size emulsion, and (c) RIBI® adjuvant system (RAS), (Ribi Immunochem, Hamilton, Mont.) containing 2% Squalene, 0.2% Tween 80, and one or more bacterial cell wall components such as monophosphorylipid A (MPL), trehalose dimycolate (TDM), and cell ...
Immunostimulant activity of dry fruits and plant materials used in indian traditional medical system for mothers after child birth and invalids.
0110] 78 dairy replacement calves (initial age=18±6.3 days and body weight=43±6.1 kg) were fed with 2 L of milk replacer (MR) twice daily via a bottle at 07.30 h and 16.30 h until 45 days of life, and then a daily dose of 2 L of MR at 07.30 h for an additional week. At 37 day of age half of the calves received a daily dose of 3 g of the combination of Nucleoforce® (Bioiberica, Spain) and AHCC (AminoUp, Japan) supplemented through the morning feeding of MR until weaning time (52 days). After weaning, calves were moved from individual hutches into pens holding 8 animals until reaching 111±2.1 days (when the study was completed). Animal performance was monitored from 52 until 111 days of life. Respiratory afflictions were monitored daily from 37 to 111 days of life. Blood samples from half of the animals randomly chosen from each treatment group were obtained by venipuncture of the jugular vein at the age of 37 days and 52 days. Incidence of respiratory afflictions was analyzed using ...
Iomai Corporation (Nasdaq: IOMI) today announced that it has signed an agreement with Merck & Co., Inc. to conduct proof-of-principle preclinical studies evaluating the use of the
Decrease staff injury and patient fall risk with the TMM6 Stretcher-Chair from TransMotion by Winco. Its a pre-op chair, power driven stretcher, surgical
World-class TDM Synthesizer Plug-in for Pro Tools! | Free shipping. Questions? Call 928.284.1619. Dedicated staff standing by. Refurbished and used pro audio.
2014 Strategies for the Spanish Therapeutic Drug Monitoring (TDM) Market Published by VPGMarketResearch.com at researchbeam.com [Report Price $1500]
[247 Pages Report] Check for Discount on UK Therapeutic Drug Monitoring (TDM) Market: Future Horizons and Growth Strategies--Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities report by Venture Planning Group. This new 247-page report from VPGMarketResearch.com provides a...
The loadouts dont bother me. Not even a little. Starting with (some) weapons narrows the item control game down to the big powerups and eliminates weapon starvation in TDM. It makes it easier to control a map, maybe, but thats really not something casual players (read: practically everyone) should be complaining about. Furthermore, the default TDM mode (which is all the beta is, plus Warpath) is basically just Clan Arena, only not round-based. CA is the ultimate casual arena FPS multiplayer experience, so I think they more or less captured a similar feel for the masses of casual players. I think its fun as fuck, and Ive historically been kind of a purist when it comes to DOOM deathmatch. Im assuming theres a duel mode where loadouts arent a thing, and even if theres not, it can be made (and instantly will be) in SnapMap. I saw a comment in the reddit thread about this where a guy linked a screenshot of the matchmaking lobby and was like See? Its just a CoD ripoff. Seriously. Yeah ...
All these matches will be broadcasted on GTV. The dates and times are still subject to change and the news will be updated as often as needed. If you happen to be the captain of a nation which hasnt scheduled its match yet: you know what to do, so do it now ...
halo1_HangEmHigh_V2 . WIP - Some Bugs Present. tdm/gungame/dm. V2 with more Dynamic Lighting & Other Improvements, V1_Beta is still up if you prefer that version.
Prodajna mesta:. PLOJ JOŽICA - Kava bar AS, Maistrova ulica 13, Lenart - na avtobusni postaji v Lenartu. KMETEC MITJA - trgovina SOM, Mariborska c. 60, Sv. Trojica - pri jezeru Sveta Trojica. ČERNOŠA TATJANA - Ribiška pot 8, Sv. Trojica - pri jezeru Sveta Trojica. Spletni nakup:. Spleten nakup je možen TUKAJ. ...
- Protects and strengthens the intestinal mucosa - Stimulates the immune system, reducing the risk of diseases - Improves digestion - Optimizes the absorption of nutrients - It has an anti-stress effect, especially in situations such as transport, exp
Biologic therapy has revolutionized the treatment of immune mediated inflammatory diseases (IMID), cancer and infectious diseases. However, there is a considerable variation in clinical response to biologic therapy. Primary non-response and loss of therapeutic response to biologics have been attributed to pharmacokinetics (e.g. inadequate trough concentrations) and inflammatory processes (mechanistic failure). In addition, this lack or loss of response may originate from several little-known epigenetic mechanisms. Factors that influence the pharmacokinetics of a biologic should be taken into account (antidrug antibodies, serum albumin, serum levels of C-reactive protein, disease mediated clearance, body weight, and gender among others). Hence, to optimize the efficacy of biologic treatment, there is a need to implement personalized medicine in IMID and oncology. This can be guided by therapeutic drug monitoring (TDM).. The TDM of Biologics Scientific Committee was officially installed in the ...
The winner of the TDM/Toxicology Division Best Abstract Award will receive a $500 grant and recognition at the TDM/Toxicology Division meeting during the AACC Annual Scientific Meeting.
Electronic speed controller of your dreams. Boost your RC airplane with up to 500A peak current. TMM 40063-3 is fully configurable and programmable ESC.
FCTEL Technology Co.,Ltd a high-tech company. Our product include Fiber Optical Multiplexer,PDH/SDH Multiplexer, Interface Convertor,PCM Mux,Fiber Media Converter,indurtrial Ethernet switch,video/audio/data fiber multiplexer,E1/v.35/ RS232,422,485 fiber modem,TDM over IP,and so on.
FCTEL Technology Co.,Ltd a high-tech company. Our product include Fiber Optical Multiplexer,PDH/SDH Multiplexer, Interface Convertor,PCM Mux,Fiber Media Converter,indurtrial Ethernet switch,video/audio/data fiber multiplexer,E1/v.35/ RS232,422,485 fiber modem,TDM over IP,and so on.
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Shop a large selection of Therapeutic Drug Monitoring Reagents, Controlsand Calibrators products and learn more about Thermo Scientific CEDIA Therapeutic Drug Monitoring (TDM)
23-c-di-AMP, a synthetic STING agonist, is a more potent immunostimulant in mammals than the natural bacterial cyclic dinucleotide 33-c-di-AMP. At low concentrations, the synthetic analog induces higher levels of type I IFNs than does c-di-AMP.
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
This new 247-page report provides a comprehensive analysis of the French therapeutic drug monitoring market, including emerging tests, technologies, instrumentation, ...
Clayoo 2.6, the new free-form software from TDM Solutions, is an advanced modeling application with the ability to effortlessly create any form efficiently and accurately, however complex. It is like modeling by hand: this is the concept of Clayoo 2.6, it doesn
Ore-ško-vić se po-ka-zao kao od-go-vo-ran čo-vjek, po svoj-stvi-ma mu da-jem po-zi-tiv-nu ocje-nu, ali po eko-nom-skoj dok-tri-ni ko-ju zas-tu-pa ne-ga-tiv-nu. Ne-ma ras-ta uz euro-krat-ske im-pe-ra-ti-ve. VILIM RIBIĆ sin-di-ka-lac
The human MHC class I-like molecule CD1b is distinctive among CD1 alleles in that it is capable of presenting a set of glycolipid species that show a very broad range of variation in the lengths of their acyl chains. A structure of CD1b complexed with relatively short acyl chain glycolipids plus detergent suggested how an interlinked network of channels within the Ag-binding groove could accommodate acyl chain lengths of up to 80 carbons. The structure of CD1b complexed with glucose monomycolate, reported in this study, confirms this hypothesis and illustrates how the distinctive substituents of intracellular bacterial glycolipids can be accommodated. The Ag-binding groove of CD1b is, uniquely among CD1 alleles, partitioned into channels suitable for the compact accommodation of lengthy acyl chains. The current crystal structure illustrates for the first time the binding of a natural bacterial lipid Ag to CD1b and shows how its novel structural features fit this molecule for its role in the immune
Therapeutic drug monitoring (TDM) has been a common practice to optimize efficacy and safety of vancomycin. While vancomycin trough-only TDM has widely been integrated into pediatric clinical practice since 2009, recently updated vancomycin TDM guidelines published in March 2020 recommend area under the curve (AUC) based TDM for vancomycin instead of trough-only TDM. In this review, we discuss the rationale behind the change in TDM recommendations, describe two approaches for calculating vancomycin AUC in clinical practice, and address considerations for integrating vancomycin AUC TDM into pediatric clinical practice. Our primary goal is to provide pediatric clinicians with a resource for implementing vancomycin AUC monitoring into clinical care.
Genes at the Rp1 rust resistance locus of maize confer race-specific resistance to the common rust fungus Puccinia sorghi. Three variant genes with nonspecific effects (HRp1 -Kr1N, -D*21 and -MD*19) were found to be generated by intragenic crossing over within the LRR region. The LRR region of most …
A switch switches time division multiplexed (TDM) data and packet data from input ports to output ports. The swich comprises: a plurality of input ports receiving data, wherein each data comprises either TDM data or packet data; a plurality of output ports transmitting switched data; and a shared memory coupling the input ports to the output ports. The shared memory sequentially receives the data from the input ports, and switches a sequentially received data from a respective input port to a respective output port. Switching of packet data by the shared memory has no latency or jitter effect on switching of TDM data by the shared memory.
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For most oral anticancer drugs, blood samples will be taken at 4, 8 and 12 weeks after start of treatment to measure the concentration of the drug in the blood of the patient. Based on this concentration and patient characteristics an advise on the dosing of the treatment will be given to the treating physician. Together with the patient the treating physician will discuss the recommendation and possibly implement it. After 4 weeks the intervention will be evaluated and if necessary further improved. After 12 weeks the aim is to reach the most optimal dose for the individual patient. Every 12 weeks there after the dose will be monitored and if necessary improved ...
On Monday, all PRP had to sit for Forensic Exam as one of the requirement to be an FRP next year. And me must pass with at least 50% marks. For me, this exam is quite tough although its an open book exam. We only be allowed to bring in two law books and code of conduct. The SAQ is kinda straightforward, the only problem was that I felt like wanna write everything into the answer sheets. But when I reached the later questions, my answers all became short. Hahaha.. For MCQ, this was very tough. Flipping the books made the exam more time consuming. I didnt manage to complete all 50 questions, I think I missed around 3-5 questions. Same for SAQ, I had no time to the the final 6 marks question. Lets hope we all pass without needing to re-sit for another paper. Malasnyaaaaaa ...
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... protects M. tuberculosis from the defenses of the host. Specifically, cord factor on the surface of M. tuberculosis ... Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor ... Cord factor's amphiphilic nature leads to varying structures when many cord factor molecules are in close proximity. On a ... As the monolayer surface area of cord factor increases, so does its toxicity. The length of the carbon chain on cord factor has ...
The chord factor called the "fifth" (pitch name "G") is represented in voice 2 (shown in red). The chord factor that is in the ... In music, a factor or chord factor is a member or component of a chord. These are named root, third, fifth, sixth, seventh, ... Chord factors are taken into consideration in voicing and voice leading. A chord contains exactly as many factors as it ... The illustration shows the theoretical construction of a C13 chord having seven chord factors, with the "extended" chord ...
In music, the third factor of a chord is the note or pitch two scale degrees above the root or tonal center. When the third is ... In jazz chords and theory, the third is required due to it determining chord quality. The third in both major and augmented ... chords is major (E♮ in C) and the third in both minor and diminished chords is minor (E♭ in C). In music and music theory, a ... tenth is the note ten scale degrees from the root of a chord and also the interval between the root and the tenth. Since there ...
ISBN 978-0-07-310188-0. (Articles with hAudio microformats, Chord factors, Eleventh chords). ... also known as the jazz sus chord). Elektra chord Jazz chord Bridge chord Smith, Johnny (1980). Mel Bay's Complete Johnny Smith ... Abbey Road in a dominant eleventh chord), turning the chord into a suspended ninth chord (e.g. C9sus4, C-G-B♭-D-F), which can ... an eleventh chord is a chord that contains the tertian extension of the eleventh. Typically found in jazz, an eleventh chord ...
93 Conference on Human Factors in Computing Systems: 88-94. Lytton, Charlotte (11 January 2022). "This could help you type at ... A keyset or chorded keyboard (also called a chorded keyset, chord keyboard or chording keyboard) is a computer input device ... "Chorded keyboard , Art of Chording". "PIC-Key chorded keyboard". Cuddlepuddle. Retrieved 2011-10-24. "Spiffchorder Project". ... Unlike pressing a chord on a piano, the chord is recognized only after all the keys or mouse buttons are released. Since ...
Yerlikaya G, Pils S, Springer S, Chalubinski K, Ott J (2015). "Velamentous cord insertion as a risk factor for obstetric ... The exact cause of velamentous cord insertion is unknown, although risk factors include nulliparity, the use of assisted ... The following have been identified as risk factors for velamentous cord insertion: Nulliparity History of infertility The use ... Velamentous cord insertion is a complication of pregnancy where the umbilical cord is inserted in the fetal membranes. It is a ...
Prevention and treatment of these modifiable risk factors could reduce the likelihood of spinal cord stroke. As the high ... Unlike anterior spinal cord stroke, motor functions are not handicapped in posterior spinal cord stroke. In central spinal cord ... Spinal cord stroke is a rare type of stroke with compromised blood flow to any region of spinal cord owing to occlusion or ... Preventions of the disease include decreasing the risk factors and maintaining enough spinal cord perfusion pressure during and ...
Martin Popoff (2021). Power Chord Press (ed.). Wheels of Steel - the explosive early years of the NWOBHM p.193. Canada. ISBN ... Dome, Malcolm (2014). "The Ex-Factor". Classic Rock presents Iron Maiden: From the East End to the World: 8-9. Newhouse, Steve ...
A review of the factors influencing walking recovery after spinal cord injury". Frontiers in Human Neuroscience. 8: 141. doi: ... A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms ... Thus it is not a true spinal cord syndrome since it is nerve roots that are damaged and not the cord itself; however, it is ... Central cord syndrome, almost always resulting from damage to the cervical spinal cord, is characterized by weakness in the ...
... and inflammatory factors may also act as predisposing or aggravating factors. Inflammatory factors may include allergies, ... Predisposing factors include profession, gender, dehydration, respiratory infection, and other inflammatory factors. For ... Vocal cord nodules are bilaterally symmetrical benign white masses that form at the midpoint of the vocal folds. Although ... There are several factors that may predispose an individual to vocal fold nodules. Activities or professions that may ...
"Risk Factors for Brain and Spinal Cord Tumors". www.cancer.org. Retrieved 2019-06-28. "Signs and Symptoms of Adult Brain and ... A central nervous system tumor (CNS tumor) is an abnormal growth of cells from the tissues of the brain or spinal cord. CNS ... A few risk factors are known, including radiation exposure, genetic disorder, a family history of CNS tumors, immunodeficiency ... Tumors located in the spinal cord usually have symptoms that start with back pain that spreads towards the arms or legs. These ...
When stem cells are injected in the area of damage in the spinal cord, they secrete neurotrophic factors, and these factors ... Spinal cord injury research seeks new ways to cure or treat spinal cord injury in order to lessen the debilitating effects of ... Spinal cord implants, such as e-dura implants, designed for implantation on the surface of the spinal cord, are being studied ... The theory behind the new spinal cord stimulator is that in certain cases of spinal cord injury the spinal nerves between the ...
"On Top of the World Chords". ultimate-guitar.com. Retrieved 3 April 2013. "- Watch The X-Factor Clips - Official site". "'On ... The song incorporates the chord progression of C-F-C-Dm in the verses, and F-C-G-Dm in the chorus and bridge, with the pre- ... Imagine Dragons performed the song live on the Australian version of The X Factor in 2013. "On Top of the World" was licensed ...
Upon activation by cord factor, Mincle binds the Fc receptor FcRγ and Syk. Cord factor also binds and activates the related C- ... It is a pattern recognition receptor that can recognize glycolipids including mycobacterial cord factor, trehalose-6,6'- ... "C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor". Immunity. 38 (5): ... "Mincle is a long sought receptor for mycobacterial cord factor". Journal of Experimental Medicine. 206 (13): 2879-88. doi: ...
Prolapsed cord can only happen after the membranes have ruptured. The umbilical cord delivers before the presenting part of the ... Some unknown factors cause vascular damage in the endothelium, causing hypertension. If severe, it progresses to eclampsia, ... If the foetus is not delivered within minutes, or the pressure taken off the cord, the foetus dies. Obstetrical hemorrhage may ... Specialised ultrasound equipment can also evaluate the blood flow velocity in the umbilical cord, looking to detect a decrease/ ...
Former member of X-Factor on Krakoa. Currently deceased. Radian (Christian Cord) - Depowered as a result of M-Day. Redneck ( ... Tattoo (Christine Cord) - Depowered as a result of M-Day. Currently deceased. Mentored by Rogue. Boggart (Robin Wise) - ... Current member of X-Factor on Krakoa. Vulcan (Gabriel Summers) - Omega-level mutant. Trained to rescue the original X-Men team ... Later murdered but resurrected on Krakoa, serving with X-Factor. Elixir (Josh Foley) - Omega-level mutant; current member of ...
Because the disruption of the BSCB is a major exacerbating factor in SCIs, reestablishment of normal function is critical to ... Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI. NMR Biomed 2009;22: ... Because of its function as a protective barrier for the spinal cord, disruption of the BSCB exposes spinal cord tissue to ... The cross-talk between autophagy and endoplasmic reticulum stress in blood-spinal cord barrier disruption after spinal cord ...
The fact that the staff was used more as a defensive weapon was a determining factor in the tests, and the taiaha was given the ... The bat broke a pig's spine with a single swing, which was clocked at over 100 mph, breaking five segments of the spinal cord. ... A second strike broke the spinal cord and a third completely shattered the skull, removing all brain matter from the brainpan. ... The iklwa pierced a lung and severed the carcase's spinal cord. The weapon also penetrated a sample of unriveted chainmail and ...
"Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord". ... BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a ... "Brain-derived neurotrophic factor". Growth Factors. 22 (3): 123-31. doi:10.1080/08977190410001723308. PMC 2504526. PMID ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ...
1955-56 spinal cord injury information network - info sheet 12 Simonsen, L.L., Sonne-Holm, S., Krasheninnikoff, M., Engberg, A. ... Incidence and risk factors". Injury, Int. J. Care Injured 38: 1146-1150. Cipriano, C.A., Pill, S.G., Keenan, M.A. (2009). " ... uptake around the knees or the ankles in a patient with a very recent spinal cord injury. It is not clear exactly what this ... jaw or in patients after spinal cord trauma. Single dose radiation therapy is well tolerated and is cost effective, without an ...
However, factors such as age, preexisting conditions, and extent of injury will affect the recovery process. CCS is ... Spinal cord injury Anterior cord syndrome Posterior cord syndrome Brown-Séquard syndrome Quencer RM, Bunge RP, Egnor M, Green ... Central cord syndrome (CCS) is the most common form of cervical spinal cord injury. It is characterized by loss of motion and ... Historically, spinal cord damage was believed to originate from concussion or contusion of the cord with stasis of axoplasmic ...
"Prognostic factors responsible for survival in sex cord stromal tumors of the ovary?A multivariate analysis". Gynecologic ... Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and testis, which ... Sex cord tumour with annular tubules, abbreviated SCTAT. These are rare tumours that may be sporadic or associated with Peutz- ... Sex cord Stroma of ovary Maoz, Asaf; Matsuo, Koji; Ciccone, Marcia A.; Matsuzaki, Shinya; Klar, Maximilian; Roman, Lynda D.; ...
In modern popular music, a sixth chord is any triad with an added sixth above the root as a chord factor. This was ... one would have an added sixth chord (C-E-G-B♭-D′-F′-A′ minus B♭-D′-F′ = C-E-G-A). 6/9 chord thirteenth chord Music: The ... These are the same notes as those of an A minor seventh chord - whether such a chord should be regarded as an added sixth chord ... The sixth factor of a chord is six scale degrees above the root. Conventionally, the sixth is third in importance to the root, ...
... (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood ... Other factors such as thrombosis or arachnoiditis can be involved. A bruit (unusual blood sounds) may be heard overlying the ... Sensory loss to pain and temperature also occurs up to the level of damage on the spinal cord, as damage to different areas ... Myelography is used to confirm the diagnosis of AVMs and it shows 'snake-like' vessels on the cord's surface. If the myelogram ...
1996). "Increased basic fibroblast growth factor expression following contusive spinal cord injury." Experimental Neurology 141 ... Ciliary neurotrophic factor (CNTF) is a cytosolic protein that is not secreted. CNTF has been shown to promote the survival of ... Mid-thoracic spinal cord lesions, optic nerve lesions, but not lesions to the sciatic nerve, have shown marked increases in ... Particularly, the response of the astrocytes to the injury varies depending on factors such as the nature of the injury and the ...
Myelin gene regulatory factor knockout delays functional recovery from spinal cord injury. Neuroscience 2012. pp. S60. Yan X, ... a p53-like transcription factor) and therefore likely act as a transcription factor. MyRF is a transcription factor that ... Myelin regulatory factor (MyRF), also known as myelin gene regulatory factor (MRF), is a protein that in humans is encoded by ... Myelin regulatory factor is encoded by the Myrf/GM98 gene in mice and by the MYRF gene in humans. The family of MyRF-like- ...
Acyl-trehaloses, such as Mycobacterial cord factor are further examples of sacharolipids. While terms are sometimes used ...
... incompletely differentiated Sex cord/gonadal stromal tumor - mixed types Mixed germ cell and sex cord/gonadal stromal tumors ... Risk factors include an undescended testis, family history of the disease, and previous history of testicular cancer. More than ... Other risk factors include inguinal hernias, Klinefelter syndrome, and mumps orchitis. Physical activity is associated with ... Other types include sex-cord stromal tumors and lymphomas. Diagnosis is typically based on a physical exam, ultrasound, and ...
Magnetic Resonance Imaging Prognostic Factors". World Neurosurgery. 99: 192-199. doi:10.1016/j.wneu.2016.12.005. PMID 27979630 ... Spinal cord injury without radiographic abnormality (SCIWORA) is symptoms of a spinal cord injury (SCI) with no evidence of ... A number of underlying mechanisms are proposed including spinal cord contusion, injury to the blood supply to the spinal cord, ... Historical literature regarding spinal cord concussion, spinal cord contusion and hyperextension/hyperflexion injuries to the ...
The seventh factor helps to define the chord as an extended chord (and not an added note chord), and also adds to the texture. ... Added tone chord Elektra chord Hendrix chord Tristan chord Upper structure triad for an examination of extended harmony with ... Extended Chords on Guitar by fretjam Extended Chords on Piano by pianogroove Chord Construction by guiterthinker (Articles with ... Technically a fifteenth chord "Chord Extensions 9ths, 11ths & 13ths , Extended Jazz Piano Chords". PianoGroove.com. Retrieved ...
Another factor, one specific to Los Angeles, was the large number of regional sports channels in the area, which has resulted ... Lazarus, David (April 8, 2016). "Why cutting the pay-TV cord turned out to be a good move". Los Angeles Times. Retrieved 2016- ... "Without sports, millions of additional consumers probably would cut the pay-TV cord". For Charter, the deal helped stem annual ...
A variety of empirical studies have demonstrated CBT's effectiveness in cases of traumatic brain injury, spinal cord injury, ... This approach, integrating both personal (e.g., deficits, impairments, strengths, assets) and environmental factors, is ... and personal factors to understand an individual's adaptation to disability. This interdisciplinary model is an acknowledgement ... "Brief problem-solving training for family caregivers of persons with recent-onset spinal cord injuries: a randomized controlled ...
"Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in ... These factors form the Bishop score. The Bishop score can also be used as a means to predict the success of an induction of ... One example of this is the belief in the Chillihuani that if a knife or scissors are used for cutting the umbilical cord, it ... Risk factors for fetal birth injury include fetal macrosomia (big baby), maternal obesity, the need for instrumental delivery, ...
G-646 SF Andre Norton The X Factor (1967) G-647 SF Will F. Jenkins (as Murray Leinster) S.O.S. From Three Worlds (1967) G-648 ... G-619 WE Barry Cord Gallows Ghost / Stephen Payne Room To Swing A Loop G-620 SF Jack Jardine (as Larry Maddock) The Golden ... G-705 WE Barry Cord The Long Wire / Merle Constiner Killers' Corral (1968) G-706 SF Samuel R. Delany The Jewels Of Aptor (1968 ...
Used for digital broadcast, the noise is less of a factor than analog broadcast, which recently makes this type of antenna a ... Indoor antennas are a common solution for cord cutting, with a variety of commercial options. They are usually considered a ...
The composition is based on a six-bar chord pattern that produces a circuitous effect due to the lack of resolution at the end ... As another factor in the album's creation, Harrison felt increasingly removed from contemporary musical trends and more ... chord] progression" as Harrison employs over the line "I go round in circles", at the end of the choruses. The first of these ... over a semitone descent from the chord of C minor to B minor. Harrison changed the key for the official recording, where the ...
Kees UR, Ford J (February 1999). "Synergistic action of stem-cell factor and interleukin-7 in a human immature T-cell line". ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ... Injection of CD34+ hematopoietic stem cells has been clinically applied to treat various diseases including spinal cord injury ...
It is highly expressed in the spinal cord, as is FAM178B. There is currently no known structure for the protein. ZNF598 is a ... A table of relevant transcription factor binding sites that correspond to the sequence and colors highlighted in the promoter ... Additionally, it is of high levels in the trigeminal nerve and spinal cord. Further, there is also high concentrations of the ...
For instance a minor chord that includes a major second factor holds a great deal more dramatic tension due to the very close ... An added tone chord, or added note chord, is a non-tertian chord composed of a triad and an extra "added" note. Any tone that ... Songs with a 7♯9 chord include "Purple Haze" and "Boogie Nights". Examples of the added-second chord or added-ninth chord ( ... Igor Stravinsky's polytonal Symphony of Psalms contains many added tone chords. A mixed third chord, also split-third chord, ...
The first year, floods destroyed the crops, but the second year, students produced fifty cords of wood, thirty barrels of cider ... 105 One factor was the New York Anti-Slavery Society's failure to pay the institute $2000 for the printing costs of their paper ...
New socio-cultural and religious factors, as well as a strong influence of theater and rhetoric, led to the development of a ... In his time, the circle of fifths established itself as the main driver of chord progressions and, according to Richard ...
... power cords, USB cables) solders printed circuit board finishes, leads, internal and external interconnects glass in television ... citing possible breaches due to other environmental factors like oxidation. The 2005 Farnell/Newark InOne "RoHS Legislation and ...
Power connector - The receptacle for the power cord. Power switch - A switch to turn the monolight on and off. Slave sensor - A ... While the electrical energy used in firing the flash is usually the most significant factor, light output is also affected by ...
Code Talker was ordered by Skull Face to duplicate the vocal cord parasite for use in his plan under the threat of the ... regardless of other factors. Kaz Miller helps develop MSF into a private military contractor offering a wide range of services ... He uses this as a pretext to develop a strain of vocal cord parasite that targets English speakers, intending to unleash it ... She is infected with the English-language strain of vocal cord parasites as a means of assassinating Snake, demanding her ...
The general pathway of a spinal reflex is one which involves neurons contained within the spinal cord. However, the brain may ... has been noted that the muscle activation response to cutaneous receptor stimulation can be modulated by a variety of factors. ... The medium-latency reflex (MLR) utilizes interneurons within the spinal cord and is typically ~80-90 ms. The long-latency ...
Arpley Chord) (Extension of Time) Order 1994 (S.I. 1994/1039) Education (Groups of Grant-maintained Schools) Regulations 1994 ( ... Judicial Factors Rules) (Amendment) 1994 (S.I. 1994/2354) Redbridge Health Care National Health Service Trust (Transfer of ... Social Security Revaluation of Earnings Factors Order 1994 (S.I. 1994/1105) Academic Awards and Distinctions (The Royal ...
A stall fence is a flat plate in the direction of the chord to stop separated flow progressing out along the wing Vortex ... The normal stall speed, specified by the VS values above, always refers to straight and level flight, where the load factor is ... Therefore, given that the stall always occurs at the same critical angle of attack, by increasing the load factor (e.g. by ... This angle is dependent upon the airfoil section or profile of the wing, its planform, its aspect ratio, and other factors, but ...
The discovery that the protein called brain-derived neurotrophic factor (BDNF) is involved in the neuroimmune interactions ... Barbara Turnbull Award for spinal cord research, Barbara Turnbull Foundation, CIHR and Brain Canada 2013: Top 10 discoveries of ... suffering from neuropathic pain could be due to a reversal of the mechanisms that suppress pain signals in the spinal cord. The ...
The vessels originate in the abdomen and course down through the inguinal canal as part of the spermatic cord on their way to ... these factors may also exacerbate the risk that varicocele will affect fertility. Following discovery of the sign of swelling ... "Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair". European ...
Lovett asked how to distinguish whether paralysis was caused by poliomyelitis or by a clot or lesion of the spinal cord.: 183- ... explored the predisposition thesis by increasing the increasing the prior probability of polio in his analysis by a factor of ... 58 Keen diagnosed a clot of blood to the lower spinal cord, and prescribed massage of the leg muscles. Eleanor and Howe began ... and inpatient rehabilitation for amputees and people recovering from spinal cord injuries, brain damage, and stroke. The ...
As the neural tube begins to develop, the notochord begins to secrete a factor known as Sonic hedgehog (SHH). As a result, the ... Spinal Cord Sectional Anatomy. Animation in the reference. Diagrams of the spinal cord. Cross-section through the spinal cord ... The spinal cord is made from part of the neural tube during development. There are four stages of the spinal cord that arises ... As the spinal cord terminates at the L1-L2 level, other segments of the spinal cord would be positioned superior to their ...
When Montag reads Dover Beach to them, he strikes a chord in Mrs. Phelps, who starts crying over how hollow her life is. Mrs. ... As time went by, Bradbury tended to dismiss censorship as a chief motivating factor for writing the story. Instead he usually ... Book-burning censorship, Bradbury would argue, was a side-effect of these two primary factors; this is consistent with Captain ...
... chlorhexidine cord cleansing (to prevent umbilical cord infections); and injectable antibiotics (to treat newborn sepsis and ... Relevant factors may include lack of health insurance, illegal immigration by women with poor prenatal care, and maternal ... Vitamin A deficiencies are a contributing factor each year in 1.3 million deaths due to diarrhea and almost 118,000 deaths from ...
There's a Mobyness about its uplifting chords while the range of quirky samples and strings are reminiscent of The Avalanches. ... it makes The Prodigy sound like they've got The X Factor." The 'alternate version' featuring a full band and horn section ...
Variable decelerations: generally a result of umbilical cord compression, and contractions may further compress a cord when it ... Tarvonen, Mikko (2021). "Factors Associated with Intrapartum ZigZag Pattern of Fetal Heart Rate: A Retrospective One-Year ... It has been linked with rapidly progressing hypoxia, for example due to an umbilical cord compression, and it is presumed to be ... 2020) reported: "ZigZag pattern and late decelerations of FHR were associated with cord blood acidemia, low Apgar scores, need ...
This is a rare vocal fach, as thick vocal cords are needed to produce the large, dramatic notes, which usually lessens the ... but a factor in common is that the voice must be able to convey dramatic intensity as well as flexibility. Roles written ...
They may cause pressure on the spinal cord or cauda equina, which may present as pain, muscle weakness, or dysfunction of the ... Risk factors include anatomical abnormalities and bleeding disorders. Treatment is generally with emergency surgery. The risk ...
Corticotropin-releasing factors travel to the pituitary gland, where they activate the release of adrenocorticotropic hormone ( ... travel through the sympathetic nervous system by means of preganglionic nerve fibers that emerge from the thoracic spinal cord ... This is done through the activation by the corticotropin-releasing factor (CRF), also known as the corticotropin-releasing ... is determined by the release of the corticotropin-releasing factor as the interruption of the corticotropin-releasing factor ...
PGD2, PGJ2, Δ12-PGJ2, and 15-deoxy-Δ12,14-PGJ2 activate the transcription factor, PPARγ, with 15-deoxy-Δ12,14-PGJ2 being the ... spinal cord, brain, and lung injury; injury due to ischemia in the heart, brain, kidney, and gut; and stress-induced central ... KEAP1: cytosolic KEAP1 serves to promote the degradation of Nrf2 by proteasomes thereby inhibiting this transcription factor ... and Insulin-like growth factor 1; and e) regulating agents such as HSP70, GPR78, Gadd153, Ubiquitin B, and Ubiquitin C which ...
Table 2. Factors Affecting Implementation of California Childhood Obesity Research Demonstration Project (CA-CORD), by Sector, ... Factors Affecting Implementation of the California Childhood Obesity Research Demonstration (CA-CORD) Project, 2013. Prev ... Factors Affecting Implementation of the California Childhood Obesity Research Demonstration (CA-CORD) Project, 2013. ... Implementing CA-CORD not required or rewarded by leadership. *Consistent, supportive contact from CA-CORD staff can create ...
Exosomes have been identified as a new type of major paracrine factor released by umbilical cord-derived mesenchymal stem cells ... Significance: Exosomes have been identified as a new type of major paracrine factor released by umbilical cord-derived ... Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting ... We found that umbilical cord-derived MSCs (uMSCs) reduced scar formation and myofibroblast accumulation in a skin-defect mouse ...
... ... Modarressnejad, V. (‎2005)‎. Umbilical cord blood pH and risk factors for acidaemia in neonates in Kerman. EMHJ - Eastern ... Mean [‎SD]‎ umbilical cord blood pH was 7.25 +/- 0.14 and 81 cases had acidaemia [‎pH , 7.1]‎. Apgar score at 1 minute and ... Umbilical cord blood acid-base alterations are related to subsequent adverse outcome vents for neonates ...
... * ... The correlation between nitric oxide and vascular endothelial growth factor in spinal cord injury. Spinal Cord. 46:113-117. ... Hypoxia inducible factor-1α expression pattern in spinal cord in different groups (A) 1 d, (B) 3 d and (C) 7 d after operation ... Vascular endothelial growth factor expression pattern in spinal cord in the different groups (A) 1 d, (B) 3 d and (C) 7 d after ...
Hb9 (Mnx1) is a transcription factor described as a spinal cord motor neuron (MN)-specific marker and critical factor for the ... Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord. Sunjay Letchuman, Ashley ... We cultured spinal cord progenitors in vitro and found that gliogenesis was increased by treatment with the caudalizing factor ... The transcription factor Hb9 is key in postmitotic specification of spinal cord motor neurons (MNs), and thought to be ...
This page is dedicated to The X Factor (U.S.). You can find pictures,photos,lyrics,tour dates,chords and much more ... Biography: The X Factor is an American television music competition to find new singing talent; the winner of which receives a ...
The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are ... The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are ... The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are ... The mycobacterial cord factor Trehalose-6,6-dimycolate (TDM) and its synthetic analogue Trehalose-6,6-dibehenate (TDB) are ...
Understanding potential spinal cord injury complications can help you or your loved one seek medical care in a timely manner. ... However, sleep disturbances after a spinal cord injury may occur due to a variety of factors. ... How to Treat Spinal Cord Injury Complications. Every spinal cord injury is unique, and the complications that may arise also ... Overview of Spinal Cord Injury Complications. Learning how to cope with spinal cord injury complications such as osteoporosis, ...
Opioid growth factor arrests the progression of clinical disease and spinal cord pathology in established experimental ... An endogenous neuropeptide, opioid growth factor (OGF), chemically termed [Met(5)]-enkephalin, arrested the progression of ... and prevent further spinal cord pathology. The data extend our observations that OGF given at the time of disease induction ...
Save our spines: Animal study shows basic fibroblast growth factor protects injured spinal cord motor endplates. ... The effect of basic fibroblast growth factor on motor neurons in the anterior horn of the injured spinal cord, and on the ... In current studies, the degeneration and protection measures in the distal end of the injured spinal cord and target organ ... Jianlong Wang and team from Third Xiangya Hospital of Central South University established a rat model of spinal cord injury ...
Risk Factors. Trauma is more common in people aged 1 to 44 years. Other things that raise the risk are:. *Lack of car or boat ... Acute Spinal Cord Injuries are treated at Upstate Brain and Spine Center. ... Traumatic spinal cord injury. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/traumatic-spinal-cord- ... Management of chronic spinal cord injury. EBSCO DynaMed website. Available at: https://www.dynamed.com/management/management-of ...
It may result from direct injury to the cord itself or indirectly from disease of the nearby bones, tissues, or blood vessels. ... Spinal cord trauma is damage to the spinal cord. ... Risk factors include:. *Participating in risky physical ... Spinal cord trauma is damage to the spinal cord. It may result from direct injury to the cord itself or indirectly from disease ... The spinal cord contains nerve fibers and cells. These nerve fibers carry messages between your brain and body. The spinal cord ...
... isolates progenitor cells from cord blood by negative selection. We regret to inform our customers that we can no longer ... Human Cord Blood Progenitor Cell Enrichment Cocktail with HetaSep™ ... What factors affect cell recovery? The temperature of the reagents can affect cell recovery. All reagents should be at room ... Can RosetteSep™ be used to enrich progenitors from cord blood? Yes. Sometimes cord blood contains immature nucleated red cells ...
Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord ... Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord ...
Health: Risk factors associated with long COVID in adolescentsNature Communications. Return to research highlights ... Zhigang He and his colleagues studied a model of spinal cord injury in mice, and found that the activity of the growth- ... suggests that targeting these enzymes may be beneficial to treat spinal cord injury. ... the regulatory mechanisms that limit mTOR activity in the adult nervous systems may be beneficial to treat spinal cord injury ...
Spinal cord injury (SCI) is a major cause of physical disability and leads to patient dissatisfaction with their quality of ... Spinal cord injury (SCI) is a major cause of physical disability and leads to patient dissatisfaction with their quality of ... Basic Fibroblast Growth Factor. Basic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family that is ... 2003). Factors influencing body composition in persons with spinal cord injury: a cross-sectional study. J. Appl. Physiol. 95, ...
3) Spinal cord RF is located in the intermediolateral zone. It sends ascending and receives descending signals to coordinate ... Clinical considerations discus commonly encountered problems of spinal cord injury service and science. Every clinical ... spinal cord repair and comprehensive management are discussed to enlighten the clinical importance of the RF. ... The underlying human factors are anatomical and pathophysiological. The key to maintaining normal skin trophic is its blood ...
Traumatic spinal cord injury (SCI) means there is damage to the nerves that run through the backbone (spine). Depending where ... Risk Factors: Men between the ages of 15 and 35 are most likely to have an SCI. Older people also have SCIs because of falls. ... which then crush and destroy the cord and its nerve cells that carry signals up and down the spinal cord between the brain and ... Condition: A spinal cord injury usually is from a sudden, trauma or a blow to the spine (the backbone) that fractures or ...
Cord Blood Thyroid Stimulating Hormone Level - Interpretation in Light of Perinatal Factors. Indian Pediatrics. 2014 January; ... Objectives: To study the influence of perinatal factors on cord blood TSH (CB TSH) levels. Design: Cross-sectional study. ... Cord Blood Thyroid Stimulating Hormone Level - Interpretation in Light of Perinatal Factors. ... The effect of perinatal factors on the CB TSH levels was analyzed statistically. Results: The median CB-TSH was 8.75 microIU/mL ...
retractable cord leashs was developed after steelmancycles.com spent countless ... You can find a list of every product retractable cord leashs has reviewed. ... Factors To Consider When Shopping Online At retractable cord leashs. Is retractable cord leashs what youre looking for? When ... 4. Factors that affect functionality. Ensure your retractable cord leashs works properly once you receive it. Specifications ...
For sure, when the heart stops, we treat disease-not a risk factor. ... Its about time electrophysiology began cutting the cord. Of course we should be careful about anything that is new and novel. ... Cite this: Cutting the Cord in Cardiac Pacing-Finally! - Medscape - Sep 01, 2015. ...
The Drexel Spinal Cord Research Centers five Core Facilities have been developed over the last 20 years of funding of the ... Several factors influence these choices such as:. *Rapid acquisition of data. *Test reliability ... Spinal Cord Research Center Core Facilities. Five Cores have been developed over the last 20 years of funding of the Program ... This is achieved through regularly scheduled and highly interactive meetings of the members of the Spinal Cord Center, regular ...
Top Factors To Consider While Real Estate Investing * How To Foster A Positive Team Environment In Nursing ... Can You Plug A Power Strip Into An Extension Cord * How To Grow An Olive Tree From Seed ...
Prognostic factors in the treatment of intramedullary spinal cord tumors Andrei Koerbel , Curitiba, , PR, , Hospital Nossa ... Factors as sex, age and tumors size also did not demonstrate significance in predicting prognostic after surgery, whereas ... 35 patients harboring intramedullary spinal cord tumors who were submitted to microsurgery were analyzed. There were 24 males ( ...
Take these Factors into Consideration Before Purchasing Your toshiba tablet power cord. Usually, before buying anything, we ... Package includes 1 x 65W power cord charger, 1 x ac cord, 2 x plugs ... Best toshiba tablet power cord : Top 10 Picks for 2022. 1. LVSUN Universal Laptop Charger 90W 12-24V One for All - Slim AC ... 2. Power Cord Cable Fit for Lenovo IBM Asus Vivobook Samsung Toshiba Thinkpad Ideapad Dell inspiron Chromebook Yoga Flex X1 ...
RESULTS:All spinal cord injury patients had restrictive pulmonary dysfunction compared to the control group of healthy ... MATERIAL AND METHODS:Thirty patients with C4-C5 cervical spinal cord injury of more than 1 year and thirty healthy volunteers ... Pulmonary function was impaired in spinal cord injury patients. Ultrasonography of the diaphragm as a non-invasive method that ... Diaphragmatic excursion in spinal cord injury patients was increased on the right hemi-diaphragm during tidal breathing. ...
Umbilical cord blood pH and risk factors for acidaemia in neonates in Kerman  Modarressnejad, V. (‏2005)‏ A prospective cross- ... A major factor cited for this regression was a surge in vaccine refusals by parents and caretakers. Aims: To assess the reasons ... Mean [‏SD]‏ umbilical cord blood pH was 7.25 +/- 0.14 and 81 cases had acidaemia [‏pH , 7.1]‏. Apgar score at 1 minute and ... We assessed prevalence of cardiovascular risk factors, ischaemic heart disease [‏IHD]‏ and unhealthy lifestyles in 3723 ...
S. F. Malochet-Guinamand, F. Durif, and T. Thomas, "Parkinsons disease: a risk factor for osteoporosis," Joint Bone Spine, vol ... There were severe cord compression and cord signal change at this level (Figure 4). She also had diffuse spondylosis, kyphosis ... Acute Spinal Cord Contusion in a Patient with Multiple Upper Cervical Fractures, Parkinsons Disease, and Torticollis: Surgical ... Cervical MRI (STIR) showing increased STIR signal in the spinal cord at the C1 level (orange arrow) and odontoid fracture ( ...
The objectives of rehabilitation after an individual has sustained an acute spinal cord injury (SCI) include maximizing the ... Factors predictive of survival and estimated years of life lost in the decade following nontraumatic and traumatic spinal cord ... Factors predicting motor recovery and functional outcome after traumatic central cord syndrome: a long-term follow-up. Spine. ... Anterior cord syndrome. Anterior cord syndrome, which is characterized by a variable loss of motor and pinprick sensation, has ...
  • 7 at 1 minute, meconium-stained amniotic fluid and fetal distress were significant risk factors for acidaemia in newborn infants. (who.int)
  • On multivariate analysis, requirement of resuscitation, mode of delivery and fetal distress as indication for LSCS were significant factors affecting CB TSH values. (who.int)
  • Insulin-like growth factors (IGFs) and insulin are known to play a critical role in fetal growth. (ewha.ac.kr)
  • We sought to determine the incidence , predisposing factors and fetal outcome of umbilical cord prolapse . (bvsalud.org)
  • Exosomes have been identified as a new type of major paracrine factor released by umbilical cord-derived mesenchymal stem cells (uMSCs). (nih.gov)
  • A groundbreaking, randomised controlled trial has shown that umbilical cord-derived mesenchymal stem cell infusions safely reduce risk of death and aid quicker recovery in the most severe COVID-19 cases. (healtheuropa.com)
  • Between 1993 and 1999, in the Divisions of Neurosurgery of the Hospital Nossa Senhora das Graças and the Hospital de Clínicas in Curitiba, Paraná, Brazil, 35 patients harboring intramedullary spinal cord tumors who were submitted to microsurgery were analyzed. (scielo.br)
  • Because most of the intramedullary spinal cord tumors are slow growing and locally contained, surgical extirpation, where possible, is the treatment of choice. (medscape.com)
  • In a meta-analysis by Rijs and Klimek regarding intraoperative neuromonitoring (IONM) for intramedullary spinal cord tumors, IONM had a high sensitivity and specificity, was found to prevent neurologic damage, but limited the extent of tumor resection. (medscape.com)
  • Umbilical cord prolapse is a rare obstetric emergency with adverse perinatal outcomes. (bvsalud.org)
  • Jianlong Wang and team from Third Xiangya Hospital of Central South University established a rat model of spinal cord injury using a modified Allen's method, which was injected with basic fibroblast growth factor solution via the subarachnoid catheter. (opnews.com)
  • Zhigang He and his colleagues studied a model of spinal cord injury in mice, and found that the activity of the growth- promoting enzyme mTOR was very low in injured adult neurons in the corticospinal tract. (natureasia.com)
  • A number of convenient sensorimotor tests have been developed that are not altered by repeated testing, do not require training, aversive motivation or food deprivation, and appear to be very useful in established models of spinal cord injury. (drexel.edu)
  • The researchers found after the injection, rats with spinal cord injury displayed well-recovered motor function, spinal glial scar hyperplasia was not apparent, and anterior tibial muscle fibres slowly, but progressively, atrophied, indicating the distal motor neurons and motor endplate degenerated. (opnews.com)
  • The limited plastic and regenerative capabilities of axons in the adult mammalian CNS can be enhanced by the application of a monoclonal antibody (mAb), IN-1, raised against the myelin-associated neurite growth inhibitor Nogo-A. The aim of the present study was to investigate the effects of this treatment on the functional recovery of adult rats with a dorsal over-hemisection of the spinal cord. (jneurosci.org)
  • In up to a third of cases (29.7%) of spinal hematoma, no etiological factor can be identified as the cause of the bleeding. (unboundmedicine.com)
  • The latter two factors are thought to be sufficient to cause spontaneous spinal hematoma. (unboundmedicine.com)
  • Traumatic laryngitis can be caused by overexertion of the vocal cords causing a hematoma at the laryngeal level: screams in an evening, singing in the head, screaming during great stress, etc. (massify.com)
  • Here, we investigated whether human umbilical cord derived MSC treatment could equally ameliorate acute kidney injury induced by cisplatin and prolong survival in mice with a normal immune system and those with a suppressed immune system by polyclonal antithymocyte globulin (ATG). (hindawi.com)
  • Intrapancreatic delivery of human umbilical cord blood aldehyde dehydrogenase-producing cells promotes islet regeneration. (stemcellsportal.com)
  • Vocal cord dysfunction (VCD), itself, is not associated with an elevated blood eosinophil count. (medscape.com)
  • Hb9 ( Mnx1 ) is a transcription factor described as a spinal cord motor neuron (MN)-specific marker and critical factor for the postmitotic specification of these cells. (eneuro.org)
  • The transcription factor Hb9 is key in postmitotic specification of spinal cord motor neurons (MNs), and thought to be expressed specifically in this cell population. (eneuro.org)
  • What are the factors that determine the optimal timing of physical therapy during acute inpatient rehabilitation after spinal cord injury? (edu.au)
  • In affected patients, the integrated function of the vocal cords ceases episodically, leading to acute intermittent episodes of functional airway obstruction. (medscape.com)
  • Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages. (ox.ac.uk)
  • It's especially important to note the risk factors that can increase the chances of developing certain complications. (flintrehab.com)
  • The risk factors associated with the development of HO in patients with traumatic SCI has been studied in a case control study of 264 patients by Citak et al. (medscape.com)
  • There are some factors that increase your risk of developing a brain tumour. (cancerresearchuk.org)
  • ABSTRACT In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). (who.int)
  • Family history of cancer, exposure to X-rays, smoking and use of hair dyes were not risk factors for lymphoproliferative disorders in univariate analysis. (who.int)
  • Medical risk factors 225-241 c. (cdc.gov)
  • Other risk factors Tobacco 242-245 Alcohol 246-249 Weight gain during pregnancy 250-252 d. (cdc.gov)
  • Preventive measures include control of risk factors, drugs to make blood less likely to clot, and sometimes surgery or angioplasty to open blocked arteries. (msdmanuals.com)
  • What we are learning is that there may be a common thread and risk factors that can predispose to both an autoimmune disease or to a severe reaction following viral infections, such as SARS-CoV-2. (healtheuropa.com)
  • Exposures that are more common among the cases may be considered as possible risk factors for the disease. (cdc.gov)
  • Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery. (bvsalud.org)
  • Umbilical cord prolapse remains a high risk condition to the fetus . (bvsalud.org)
  • However, the following factors can put you at a higher risk of spraining or tearing any ligament of your knee joint. (r3stemcell.com)
  • What are the causes and risk factors for bone metastases? (healthgrades.com)
  • We studied newborn care practices among mothers in Mewat, Haryana, having a high NMR and determined risk factors for unsafe practices and described the knowledge and skills of ASHAs during home visits. (who.int)
  • Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies. (who.int)
  • This study described the pattern of trichiasis, active trachoma and trachoma risk factors in 9 governorates of Yemen plus Socotra Island, using a rapid assessment during October and February 2004. (who.int)
  • The spinal cord contains nerve fibers and cells. (medlineplus.gov)
  • Spine injuries can damage the spinal cord if they are at the upper portion of the lumbar spine or the lumbar and sacral nerve roots (cauda equina) if they are at the lower lumbar spine. (medlineplus.gov)
  • Spinal cord injury (SCI) is a devastating nerve injury caused by severe trauma to the spinal cord, leading to temporary or permanent somatosensory, and motor dysfunction ( Tohda and Kuboyama, 2011 ). (frontiersin.org)
  • Injuries to the backbone cause fractures and compression of the vertebrae, which then crush and destroy the cord and its nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. (aapmr.org)
  • An injury to the spinal cord can damage a few, many, or almost all of these nerve cells. (aapmr.org)
  • [ 10 , 13 ] A hypothesis is that mediation of the vagus nerve may alter the laryngeal tone and lower the threshold for stimuli to produce vocal cord spasm or to precipitate the abnormal adduction of vocal cords. (medscape.com)
  • Multiple sclerosis (MS) is a nervous system disease that affects the brain, optic nerve (which helps you see), and spinal cord. (medlineplus.gov)
  • WHAT YOU GET: Universal laptop charger adapter with DC cable, AC cord, 12 tips, welcome card, fabric bag and instruction, 2 years guarantee and friendly customer service. (relibrary.com)
  • Factors as sex, age and tumor's size also did not demonstrate significance in predicting prognostic after surgery, whereas tumor in a thoracic level was associated with higher morbidity (p=0.021). (scielo.br)
  • When a spinal cord injury affects movement, it can result in paraplegia (paralysis of the legs) or quadriplegia (paralysis of the arms and legs), potentially creating the need for a wheelchair. (flintrehab.com)
  • If spinal cord pressure can be relieved or reduced before the spinal nerves are completely destroyed, paralysis may improve. (medlineplus.gov)
  • Paralysis from spinal cord reperfusion effect - this is an uncommon complication that causes a stroke-like effect in the spinal cord. (singhealth.com.sg)
  • The clinical signs and symptoms resemble those observed in disorders such as vocal cord paralysis , asthma , epiglottitis , laryngospasm, and angioedema secondary to anaphylaxis . (medscape.com)
  • Dr Ricordi said: "The umbilical cord contains progenitor stem cells, or mesenchymal stem cells, that can be expanded and provide therapeutic doses for over 10,000 patients from a single umbilical cord. (healtheuropa.com)
  • Placental tissue and cord blood from women with preterm and term labour were examined for microorganisms and compared in this randomized prospective study. (who.int)
  • See also Spinal Cord Injuries , Autonomic Dysreflexia in Spinal Cord Injury , Functional Outcomes per level of Spinal Cord Injury , Hypercalcemia in Spinal Cord Injury , Osteoporosis and Spinal Cord Injury , Prevention of Thromboembolism in Spinal Cord Injury , Rehabilitation of Persons with Spinal Cord Injuries , and Spinal Cord Injury and Aging . (medscape.com)
  • Incomplete spinal cord injury recovery time may vary depending on the level of injury, severity, and rehabilitation process. (flintrehab.com)
  • The authors state, "The incidence of confirmed Chagas disease among mothers who donated their neonate's cord blood varied over time," "The incidence of Chagas disease varied over time," and "A strength of this study is its large sample size, particularly because the incidence of this disease is low. (cdc.gov)
  • According to the World Health Organization [1] Spinal cord injury - WHO - https://www.who.int/news-room/fact-sheets/detail/spinal-cord-injury , the annual global incidence of spinal cord injury is 40 to 80 cases per million and this number is increasing every year. (bedroom-furniture-collection.com)
  • Brain and spinal cord tumours can affect children and adults. (cancerresearchuk.org)
  • To understand brain tumours it helps to know about the different parts of the brain and spinal cord. (cancerresearchuk.org)
  • Find out about seeing your GP, referral to a specialist and the tests you might have to diagnose a brain or spinal cord tumour. (cancerresearchuk.org)
  • Treatment for a brain or spinal cord tumour depends on the type of tumour you have, where it is and your general health. (cancerresearchuk.org)
  • Find out what you can do, who can help and how to cope with a brain and spinal cord tumours. (cancerresearchuk.org)
  • The spinal cord uses neural pathways to communicate with the brain and muscles. (flintrehab.com)
  • Under normal circumstances, cerebrospinal fluid (the clear, colorless fluid that protects and cushions the brain and spine) flows through the ventricles, brain, and spinal cord, before being absorbed into the bloodstream, the NINDS explains. (1800birks4u.com)
  • Multiple sclerosis (MS) is aptly named for the many scars it produces in the brain and spinal cord. (altmedrev.com)
  • Nerves that control each breath leave your brain and exit the spinal cord in the mid-neck (C3, C4 and C5) area. (chiropracticusasc.com)
  • Your brain is always on, performs lightning-fast calculations, and is a whiz at making connections between seemingly unrelated factors and observations. (heartwoodholistic.com)
  • Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)
  • a glottic chink is present along the posterior portion of the vocal cords, while the anterior portion of the vocal cords is adducted. (medscape.com)
  • This article will discuss what potential spinal cord injury complications can occur and what the underlying causes may be. (flintrehab.com)
  • To prevent spinal cord injury complications from worsening, it helps to understand what they are and how they can occur. (flintrehab.com)
  • Contractures occur in approximately 66% of individuals with SCI, and may develop in the early stages of spinal cord injury or later in recovery. (flintrehab.com)
  • Injury can also occur if the spinal canal protecting the spinal cord has become too narrow ( spinal stenosis ). (medlineplus.gov)
  • Furthermore, although the majority of Hb9-lineage cells at cervical spinal cord levels are MNs, at more caudal levels, Hb9-lineage cells include small-diameter dorsal horn neurons, astrocytes, and oligodendrocytes. (eneuro.org)
  • Cervical MRI (STIR) showing increased STIR signal in the spinal cord at the C1 level (orange arrow) and odontoid fracture (green arrow). (hindawi.com)
  • is compression of the spinal cord caused by abnormal development of the cervical vertebrae. (merckvetmanual.com)
  • There is ventral compression of the spinal cord due to protrusion of one or more caudal cervical disks. (merckvetmanual.com)
  • Specifically, untreated secondary effects of spinal cord injury can result in musculoskeletal and/or visceral pain. (flintrehab.com)
  • The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury, because of the loss of neural connections. (opnews.com)
  • As a result of spinal cord injury, secondary diseases can develop that can even be life-threatening. (bedroom-furniture-collection.com)
  • When neural pathways become damaged or destroyed by a spinal cord injury, it can result in loss of sensation, immobility, and other secondary effects . (flintrehab.com)
  • We performed fate-mapping experiments and found that Hb9-lineage cells are not restricted to motor neurons, but also include spinal cord macroglia and Schwann cells. (eneuro.org)
  • The effect of basic fibroblast growth factor on motor neurons in the anterior horn of the injured spinal cord, and on the number of neuromuscular junctions in target organs, remains elusive. (opnews.com)
  • These findings, published in the Neural Regeneration Research , indicate that basic fibroblast growth factor can protect the endplate through attenuating the decreased expression of calcitonin gene related peptide and acetylcholinesterase in anterior horn motor neurons of the injured spinal cord. (opnews.com)
  • Interpretation in Light of Perinatal Factors. (who.int)
  • Cord Blood Thyroid Stimulating Hormone Level - Interpretation in Light of Perinatal Factors. (who.int)
  • Objectives: To study the influence of perinatal factors on cord blood TSH (CB TSH) levels. (who.int)
  • The effect of perinatal factors on the CB TSH levels was analyzed statistically. (who.int)
  • Hence, these values need to be interpreted in light of perinatal factors. (who.int)
  • A prospective cross-sectional study was carried out to determine the relationship and predictive value of umbilical cord blood pH for adverse neonatal outcomes. (who.int)
  • There is no set timeline for recovery because every spinal cord injury is different and every survivor may experience different outcomes. (flintrehab.com)
  • Thymus derived (T) cells sensitized against myelin self-antigens secrete tumor necrosis factor, cytokines, prostaglandins, and other inflammatory mediators that strip away the myelin and sometimes destroy the axons. (altmedrev.com)
  • When NSAIDs produce inadequate disease control, the preferred next treatment choice is a tumor-necrosis factor (TNF) inhibitor. (medscape.com)
  • Therefore, we estimated the knowledge, attitude and practices among mothers regarding newborn care and determined the factors associated with unsafe neonatal care practices by mothers. (who.int)
  • Linear regression revealed that neonatal umbilical cord blood lead levels reflected the levels in maternal blood. (who.int)
  • In addition, blood lead levels in neonatal umbilical cord and mothers in the concentration was inversely and significantly associated coastal city of Tripoli and desert city of Ghadames. (who.int)
  • We interviewed mothers and ASHAs in the selected subcentres using semi-structured questionnaires on the six safe newborn care practices, namely safe breastfeeding, keeping cord and eyes clean, wrapping baby, kangaroo care, delayed bathing and hand washing. (who.int)
  • Also, for the first time, the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess α-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-β/SMAD2 signaling pathway. (nih.gov)
  • The aim of the present study was to evaluate the expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor‑1 (HIF‑1), and to investigate the role of the HIF‑1/VEGF signaling pathway following spinal cord injury (SCI). (spandidos-publications.com)
  • METHOD: sectional, descriptive and correlational study involving 49 patients with neuropathic bladder caused by spinal cord injury. (bvsalud.org)
  • The RosetteSep™ Human Cord Blood Progenitor Cell Enrichment Cocktail with HetaSep™ is designed to isolate progenitor cells from cord blood by negative selection. (stemcell.com)
  • Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors. (stemcellsportal.com)
  • If vocal cord closure occurs during both inspiration and expiration, FEV 1 can decrease along with the decrease in FVC, making the FEV 1 /FVC ratio within the reference range. (medscape.com)
  • Management of chronic spinal cord injury. (upstate.edu)
  • Available at: https://www.dynamed.com/management/management-of-chronic-spinal-cord-injury. (upstate.edu)
  • Chronic laryngitis is usually caused by prolonged exposure to irritating factors. (massify.com)
  • A few years ago, I compiled a list of links to Christmas carols and song lyrics with guitar chords . (ismckenzie.com)
  • In order to provide you with accurate and valuable pieces of information and reviews, we have conducted in-depth research for the best octopus extension cord of 2023. (curee.org)
  • Thonapa Outdoor 1 to 3 Extension Cord Splitter - 13 Foot (25 Foot Combined Length) Green Power Squid. (curee.org)
  • Create a centralized power station with our extension cord splitter and convert your single outlet into 5! (curee.org)
  • Clear Max's 1.5 foot long power extension cord is. (curee.org)
  • When these effects are left untreated, they can progress into more serious spinal cord injury complications. (flintrehab.com)
  • Thus, it's important to be aware of the potential complications of spinal cord injury and seek emergency medical attention if new symptoms arise. (flintrehab.com)
  • What Are the Complications of Spinal Cord Injury? (flintrehab.com)
  • Pain is among the most common complications of spinal cord injury. (flintrehab.com)
  • Many spinal cord injuries and cauda equina syndrome cases are medical emergencies and need surgery right away. (medlineplus.gov)
  • When spinal cord injuries are in the neck area, symptoms can affect the arms, legs, and middle of the body. (medlineplus.gov)
  • Spinal cord injury (SCI) is one of the most debilitating injuries that a person can suffer. (aihw.gov.au)
  • In this article, we will talk about what mattress is best for people with spinal cord injuries, as well as 3 mattresses that are worth looking into if you suffer from this condition. (bedroom-furniture-collection.com)
  • Other factors can also interfere with recovery time including various internal and external variables like associated injuries, diet, social support, and living environment. (flintrehab.com)
  • In the majority of spinal cord injuries (SCIs), some axonal projections remain intact. (ox.ac.uk)
  • We found that umbilical cord-derived MSCs (uMSCs) reduced scar formation and myofibroblast accumulation in a skin-defect mouse model. (nih.gov)
  • In accordance with the discovery that MSCs can produce a number of immunomodulatory molecules and secrete various soluble factors that reduce apoptosis and promote mitosis, it is believed that these properties are responsible for beneficial outcome of MSC therapy in AKI [ 9 ]. (hindawi.com)
  • The patients considered here have problems associated with abnormal vocal cord movement without an organic basis. (medscape.com)
  • Laryngitis Viral Infection results from inflammation of the larynx, especially in the vocal cords. (massify.com)
  • The inflammation prevents the vocal cords from moving normally and vibrating freely as the air passes. (massify.com)
  • Looking for the toshiba tablet power cord in the market? (relibrary.com)
  • You've come to the right spot because we've spared you the trouble of looking through tons of reviews and guidelines for finding the best toshiba tablet power cord. (relibrary.com)
  • Apparently there's a retro vogue going on in the design world when it comes to appliance, lamp, and power cords. (makezine.com)
  • It comes bundled with 2meter power cord. (dell.com)
  • Cable Matters 5 Outlet Power Cord Splitter (Power Squid Outlet Multiplier) with Extra Long 10 Foot. (curee.org)
  • UL LISTED - 3 wire power cord splitter, 13 foot end to end, 25 foot combined length (7ft leader cord with three 6ft leg cords), 13 amp, 125 volt, 1625. (curee.org)
  • Tangle-free Connection - Get rid of those cluttered cords and power strips near your wall outlets. (curee.org)
  • Maximize Your Wall Outlet- Our power cord splitter connects with any bulky charger so you can save energy and space. (curee.org)
  • Designed for datacenters and other electrically demanding applications, the PDU15M2F12 has rugged, industrial-grade metal housing and a 15-foot AC power cord. (cyberpowersystems.com)
  • Secures power cords, keeping them organized and accessible. (cyberpowersystems.com)
  • A physical therapist is a great resource for treating and preventing musculoskeletal pain after spinal cord injury. (flintrehab.com)
  • However, the dose tolerance of the spinal cord (SC) after SSRS with relation to radiation myelopathy (RM) is not well-described. (bvsalud.org)
  • Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from seconda. (bvsalud.org)
  • Consequently, the threshold for activation of the reflex responsible for vocal cords closure is lowered. (medscape.com)
  • Recently it has been demonstrated that MSC secreted factors have beneficial effects in various immune disorders, including transplantation rejection and graft-versus-host diseases (GVHD) [ 9 - 11 ]. (hindawi.com)
  • Congenital and Inherited Spinal Cord Disorders in Animals Also see Diseases of the Spinal Column and Cord. (merckvetmanual.com)
  • The spinal cord is located in the spinal canal of your spine in your neck, chest, and back down to the first lumbar vertebra. (medlineplus.gov)
  • Conditions such as rheumatoid arthritis , infection, cancer, or osteoporosis can weaken the spine, which normally protects the spinal cord. (medlineplus.gov)
  • A spinal cord injury usually is from a sudden, trauma or a blow to the spine (the backbone) that fractures or dislocates vertebrae. (aapmr.org)
  • There were severe cord compression and cord signal change at this level (Figure 4 ). (hindawi.com)
  • Spinal cord compression is due to bony proliferation of the articular processes and pedicles, usually of the C4 through C7 vertebrae. (merckvetmanual.com)
  • This can lead to pain, broken bones, and compression of the spinal cord. (healthgrades.com)
  • There were significantly greater levels of osteoblast-stimulating factors present in the sera of SCI patients with HO. (medscape.com)
  • With these mattresses, spinal cord injury patients can get prevention of pressure sores and reduce the development of existing ulcers. (bedroom-furniture-collection.com)
  • Paradoxical vocal cord motion can be confirmed on laryngoscopy performed when patients are symptomatic. (medscape.com)
  • They typically follow individuals with SCI for life providing medical management, diagnosing and treating pain, spasticity, contractures and a host of other conditions that may accompany spinal cord injury such a pressure sores, blood pressure dysregulation. (aapmr.org)
  • ONE BUTTON TO HANDLE:just use only one button to brake&Lock to handle this retractable cord leash .The steady lock you can control the length freely on your dogs.Easy to hold in a current length if you need.More safe and convenience than the traditional dog belt. (steelmancycles.com)
  • The developmental growth process in which solid chords of prostate epithelium increase in length. (mcw.edu)
  • When a chord length of 0.15 m is assumed, the Reynolds number lies in the range shown in Figure 1 . (springeropen.com)