Cord Factors: Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)TrehaloseSpinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Mycobacterium bovis: The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Granuloma, Respiratory Tract: Granulomatous disorders affecting one or more sites in the respiratory tract.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Sulfuric Acids: Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.Disaccharides: Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Oxidative Phosphorylation: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.gamma-Globulins: Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.Mitochondrial Swelling: An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.Mycobacterium: A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.Mycolic AcidsNontuberculous Mycobacteria: So-called atypical species of the genus MYCOBACTERIUM that do not cause tuberculosis. They are also called tuberculoid bacilli, i.e.: M. buruli, M. chelonae, M. duvalii, M. flavescens, M. fortuitum, M. gilvum, M. gordonae, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. kansasii, M. marinum, M. obuense, M. scrofulaceum, M. szulgai, M. terrae, M. ulcerans, M. xenopi.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Mitochondria, Liver: Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)Paramecium tetraurelia: A species of ciliate protozoa. It is used in biomedical research.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Monosaccharides: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.American Cancer Society: A voluntary organization concerned with the prevention and treatment of cancer through education and research.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)Insulin-Like Growth Factor Binding Proteins: A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)Insulin-Like Growth Factor Binding Protein 3: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Insulin-Like Growth Factor I: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.Insulin-Like Growth Factor Binding Protein 2: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Insulin-Like Growth Factor Binding Protein 1: One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)Insulin-Like Growth Factor Binding Protein 5: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Insulin-Like Growth Factor Binding Protein 4: One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Deoxyguanosine: A nucleoside consisting of the base guanine and the sugar deoxyribose.Umbilical Cord: The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Tracheostomy: Surgical formation of an opening into the trachea through the neck, or the opening so created.Cervical Vertebrae: The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.Quadriplegia: Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.Vital Capacity: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Electric Stimulation Therapy: Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.Failed Back Surgery Syndrome: A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers.Spinal Cord Stimulation: Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.Low Back Pain: Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.Back Pain: Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
... (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood ... Other factors such as thrombosis or arachnoiditis can be involved. A bruit (unusual blood sounds) may be heard overlying the ... Sensory loss to pain and temperature also occurs up to the level of damage on the spinal cord, as damage to different areas ... Myelography is used to confirm the diagnosis of AVMs and it shows 'snake-like' vessels on the cord's surface. If the myelogram ...
Upon activation by cord factor, Mincle binds the Fc receptor FcRγ and Syk. Cord factor also binds and activates the related C- ... It is a pattern recognition receptor that can recognize glycolipids including mycobacterial cord factor, trehalose-6,6'- ... "C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor". Immunity. 38: 1050 ... "Mincle is a long sought receptor for mycobacterial cord factor". Journal of Experimental Medicine. 206: 2879-88. doi:10.1084/ ...
B) Neural tube forms (C) Gives rise to the brain and spinal cord. (D) Neural crest cells will migrate to different regions ... "Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its ... The best example of this is the Neuronal-Restrictive Silencer Factor (NRSF) that is produced by the REST gene. The REST gene ... In genetics, a silencer is a DNA sequence capable of binding transcription regulation factors, called repressors. DNA contains ...
Factor (chord) Music education Tonality Jonas, Oswald (1982). Introduction to the Theory of Heinrich Schenker (1934: Das Wesen ... Degrees are useful for indicating the size of intervals and chords, and whether they are major or minor. In the most general ...
http://aac.asm.org/cgi/doi/10.1128/AAC.05708-11 cord factor. ...
1996). "Increased basic fibroblast growth factor expression following contusive spinal cord injury." Experimental Neurology 141 ... Ciliary neurotrophic factor (CNTF) is a cytosolic protein that is not secreted. CNTF has been shown to promote the survival of ... Mid-thoracic spinal cord lesions, optic nerve lesions, but not lesions to the sciatic nerve, have shown marked increases in ... Particularly, the response of the astrocytes to the injury varies depending on factors such as the nature of the injury and the ...
transforming growth factor beta receptor binding. • growth factor activity. • protein binding. Cellular component. • ... spinal cord anterior/posterior patterning. • cell development. • negative regulation of cell differentiation. • positive ... Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... "Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy". Cell. 153 (4): 828-39 ...
Floor plate cells at the ventral midline of the spinal cord secrete a diffusible factor or factors that promotes the outgrowth ... UNC-129 is a ligand in the transforming growth factor family in C. elegans which encodes transforming growth factor β (TGF-β). ... Thus, netrin-1 may not only be a chemotropic factor for neurons but also a survival factor. This discovery shows that netrin-1 ... "Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord". Cell. 78 (3): 425-35. doi: ...
"Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury". Mediators of Inflammation. 2016: 9476020 ... Factors such as myelin debris, which is formed by the injury at the damage site, has been shown to induce the phenotype shift ... Spinal Cord Injury (SCI) can be divided into three separate phases. The primary or acute phase occurs from seconds to minutes ... The M2 phenotype is associated with anti-inflammatory factors such as IL-10, IL-4, and IL-13 and contributes to wound healing ...
... is a risk factor of amyotrophic lateral sclerosis (ALS). Studies have shown significant genotypic associations for two ... P4HB is greatly elevated in ALS spinal cord. P4HB can also be nitrosylated, and elevation of nitrosylated P4HB has been shown ... as well as in transgenic mutant superoxide dismutase 1 mouse and human sporadic amyotrophic lateral sclerosis spinal cord ...
These are factors which all must be excluded for a diagnosis of functional FI, and are abnormal innervation caused by lesion(s ... Dural ectasia is an example of a spinal cord lesion that may affect continence. Liquid stool is more difficult to control than ... Other factors include the specialized anti-peristaltic function of the last part of the sigmoid colon, which keeps the rectum ... The resting tone of the anal canal is not the only factor which is important, both the length of the high pressure zone and its ...
... the chord, the arrow, the angles, their relations among a variety of parameters; methods to memorize all these factors using ... the chord connected with rising, setting, the apogee and the perigee; the method for determining the end-time of a month; the ... chord and variety of constants. Chapter 9 : Details of the Alpha aeries sign; calculation of the positions of the planets in ... chords of the epicycles and apogee for all the planets, their hypotenuse. Chapter 8 : Methods for the determination of the ...
This is a deterioration of nerves in the spinal cord, starting in the posterior part of the cord. Dogs so affected will become ... are caused by other factors.[12] [13] ... In extreme cases, this can cause spinal cord function inferior ... Paralysis is most often caused by damage in the nervous system, especially the spinal cord. Other major causes are stroke, ... Most paralyses caused by nervous-system damage (e.g., spinal cord injuries) are constant in nature; however, some forms of ...
Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene. GDF1 belongs to the ... It is found in the brain, spinal cord and peripheral nerves of embryos. "Human PubMed Reference:". "Mouse PubMed Reference:". ... Lee SJ (1990). "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily". Mol. Endocrinol. ... Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". ...
During injury, a factor entitled Akhirin is secreted in the FP region. During spinal cord development, Akhirin is expressed ... The spinal cord ependymal cells also reside in the FP region of the spinal cord. These cells are a neural stem cell population ... Netrins Are Diffusible Chemotropic Factors for Commissural Axons in the Embryonic Spinal Cord. Cell, Vol. 79, 425-435, August ... In the spinal cord, Shh is directed by both the notochord and floor plate regions which ultimately drives the organization of ...
Majority of strains possess the cord factor (trehalose 6-6' dimycolate), an important virulence factor. They are catalase ... "cord factor" (which interferes with phagocytosis by macrophages by preventing the fusion of the phagosome with the lysosome). ... May 2007). "Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched ... Nocardial virulence factors are the enzymes catalase and superoxide dismutase (which inactivate reactive oxygen species that ...
"Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord". Cell. 78 (3): 425-35. doi: ... "Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord". Proceedings of the ... DCC, which is implicated in attraction, can also serve as a co-factor in repulsion signaling when far away from the source of ... Mice with mutations in the netrin-1 gene were observed to be lacking in forebrain and spinal cord commissural axons. Netrin-3 ...
"Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord". Cell. 78 (3): 425-35. doi: ... This subsequently lead to extensive research and the discovery of two repulsive factors, Ephrin-A5 and Ephrin-A2, by observing ... The migration of the growth cone is mediated through the interaction of numerous trophic and tropic factors; Netrins, Slits, ... In the tectum, the transcription factor Engrailed creates an Ephrin-A concentration gradient along the anterior-posterior axis ...
These are also the main factors to its pathogenicity. As the fruiting body continues to grow and obtain nutrients, it forms ... With this particular fungus it will produce mycelial cords also known as rhizomorphs. These rhizomorphs allow the fungus to ... Spores can be dispersed by environmental factors such as wind, or they can be redeposited by an animal. Once the spores are in ...
Each technique varies depending on the level of the spine and the location of the compressed spinal cord/nerves.[3] After the ... Risk factors include tobacco use, nonsteroidal anti-inflammatory drug use, osteoporosis, revision procedures, decreased immune ... The most common cause of pressure on the spinal cord/nerves is degenerative disc disease.[5] Other common causes include disc ... Spinal fusion is most commonly performed to relieve the pain and pressure on the spinal cord that results when a disc ( ...
Pattern formation in the morphogenesis of an animal is regulated by genetic induction factors that put cells to work after ... "Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima". BMC Developmental Biology. 9: 3. doi:10.1186 ... This process is driven by growth factor and cytokine regulated pathways.[89] The normal sequence of inflammation and ... "Growth factors, heat-shock proteins and regeneration in echinoderms". The Journal of Experimental Biology. 204 (Pt 5): 843-8. ...
The continuous delivery of neurotropic growth factor (NGF) would increase the nerve regeneration in the spinal cord. However, ... Biochemical repair Neurotropic factor therapy and gene therapy Neurotropic growth factors regulate growth, survival, and ... Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the rest of the body, and ... These factors would promote nerve repairs to the target area. Hydrogels' macroporous properties would enable attachment of ...
An inquest found that he had hanged himself from an air vent using a length of cord. Various factors led to his suicide; a ... She tightened the cord slowly around the young woman's neck until she stopped breathing. David Birnie stood beside the bed ... Once Candy was asleep, David put the cord around her neck and told Catherine to prove her undying love for him by murdering the ... When they had satiated their lust, Birnie tried to strangle the girl with the nylon cord, but she became hysterical and went ...
Prolapsed cord can only happen after the membranes have ruptured. The umbilical cord delivers before the presenting part of the ... Some unknown factors cause vascular damage in the endothelium, causing hypertension. If severe, it progresses to eclampsia, ... If the foetus is not delivered within minutes, or the pressure taken off the cord, the foetus dies. Obstetrical hemorrhage may ... Specialised ultrasound equipment can also evaluate the blood flow velocity in the umbilical cord, looking to detect a decrease/ ...
Factors associated with willingness to try different pain treatments after a spinal cord injury. Clinical Journal of Pain, 19, ... Topics in Spinal Cord Injury, 7, 73-83. Benrud-Larsen LM, Wegener ST (2000). Psychosocial aspects of chronic pain in ... PMID 1633388 Elliott, T.R. & Wegener, S.T. (Eds.). (1992). Chronic pain and spinal cord injury (Special section). The Clinical ... San Jose Mercury News Bor, Jonathan (July 30, 2000). Baltimore's street violence creates an epidemic of spinal cord injuries. ...
... from growth factors to hormones that modulate and influence the growth and development of functional connections between ...
Cord factor protects M. tuberculosis from the defenses of the host. Specifically, cord factor on the surface of M. tuberculosis ... Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor ... Cord factors amphiphilic nature leads to varying structures when many cord factor molecules are in close proximity. On a ... As the monolayer surface area of cord factor increases, so does its toxicity. The length of the carbon chain on cord factor has ...
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent ... Cutting Edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog ... These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 adjuvanticity ...
... of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors. ... Umbilical cord matrix mesenchymal stromal cells (MSC) were transduced with the non-integrating Sendai virus encoding for the ... The generation of iTr cells by transduction of the Yamanaka reprogramming factors is not unique to equine cells. However, this ... cell-like properties are generated through the use of the Yamanaka transcription factors, OCT4, SOX2, KLF4, and MYC (OSKM). ...
Factors associated with the SCI event * Mechanism of injury. * Type of activity at time of injury ... Severe spinal cord injury is a very debilitating injury. This report presents information from the Australian Spinal Cord ... Falling was the most common type of event leading to traumatic spinal cord injury at older ages. The Australian Spinal Cord ... During the year, 280 new cases of spinal cord injury from traumatic causes were registered in Australia, an age-adjusted ...
Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms[J]. Front ... Fig.1 Compartments within the umbilical cord. Mesenchymal stem cells (MSCs) can be isolated from (1) the umbilical cord blood ... Keywords umbilical cord mesenchymal stem cells cutaneous regeneration Corresponding Authors: Fu Xiaobing,Email:[email protected] ... Umbilical cord blood. Mesoblast. CD73, CD44. CD105, CD90. CD45,CD34. No. High. Safe. Low. Lower. Easy to obtain. No harm to the ...
... the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons. ... Nerve growth factor can be delivered to the brain by intranasal administration without risk for treatment of brain diseases. Dr ... Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury. Neural ... Article: "Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury ...
1995) Transcriptional roles of nuclear factor-κB and nuclear factor-interleukin-6 in the tumor necrosis factor-α-dependent ... Traumatic Spinal Cord Injury Induces Nuclear Factor-κB Activation. John R. Bethea, Marcia Castro, Robert W. Keane, Thomas T. ... Traumatic Spinal Cord Injury Induces Nuclear Factor-κB Activation. John R. Bethea, Marcia Castro, Robert W. Keane, Thomas T. ... Traumatic Spinal Cord Injury Induces Nuclear Factor-κB Activation. John R. Bethea, Marcia Castro, Robert W. Keane, Thomas T. ...
... Anna D. Petropoulou1 and Vanderson ... Examples include injecting cord blood cells directly into the bone marrow [9], in vivo or ex vivo amplification of cord blood ... One cord blood unit predominated engraftment and none of the following factors were predictive of which unit eventually ... E. Gluckman, V. Rocha, I. Ionescu et al., "Results of unrelated cord blood transplant in fanconi anemia patients: risk factor ...
Learn about childhood brain and spinal cord cancer risk. ... Risk factors for childhood brain and spinal cord cancer are ... Risk factors for childhood brain and spinal cord tumours. A risk factor is something that increases the risk of developing ... Possible risk factors. Having a birth defect is a possible risk factor for childhood brain and spinal cord tumours. This means ... The following are risk factors for childhood brain and spinal cord tumours. Most of the risk factors are not modifiable. This ...
Patients who waited less than 2 years for a spinal cord stimulator implant experienced success rates of 75% compared with a ... Fewer than 50% of all patients report long-term success with spinal cord stimulation (SCS) for treatment of chronic pain, they ... Fewer than 50% of all patients report long-term success with spinal cord stimulation (SCS) for treatment of chronic pain, they ... Patients who waited less than 2 years for a spinal cord stimulator implant experienced success rates of 75% compared with a ...
... John D. ... Aspiration lesions created a 3 mm long cavity in the upper lumbar spinal cord of adult rats. Five weeks after injury two strips ... bound nerve growth factor has the capacity to enhance the regrowth of ascending sensory axons across a traumatic spinal cord ... Fetal spinal cord tissue was transplanted alongsideand between these strips. Six weeks post transplantation, animals were ...
The chord factor called the "fifth" (pitch name "G") is represented in voice 2 (shown in red). The chord factor that is in the ... In music, a factor or chord factor is a member or component of a chord. These are named root, third, fifth, sixth, seventh, ... Chord factors are taken into consideration in voicing and voice leading. A chord contains exactly as many factors as it ... The illustration shows the theoretical construction of a C13 chord having seven chord factors, with the "extended" chord ...
... McCall J, Weidner N, Blesch A ... Thus, growth-stimulating factors will likely have to be combined with other treatment approaches to tap into the full potential ... of regeneration limit the efficacy of neurotrophic factor delivery for anatomical and functional recovery after spinal cord ... In addition, the temporal and spatial distribution of growth factors have to be tightly controlled to achieve biologically ...
Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells.. Hillman P, Wall PD. ...
Purpose Spinal cord injury (SCI) results in severe neurological deficit. However, the functional recovery following SCI is very ... Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in ... hematopoietic stimulating factors therapy following spinal cord injury. Ann Biomed Eng 35:1647-1656. doi: 10.1007/s10439-007- ... Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, Lu M, Rosenblum M (2000) Spinal cord injury in rat: treatment with bone marrow ...
Relation of cord serum levels of growth hormone, insulin-like growth factors, insulin-like growth factor binding proteins, ... Fetal growth process is governed by multiple factors. We investigated the relation of insulin-like growth factors (IGFs), IGF ... Birth weight (BW), birth length (BL), ponderal index, head circumference (HC), and cord serum levels of albumin, prealbumin, ... Anthropometric measures were recorded and umbilical cord blood samples were collected at birth. ...
... and obstetric factors influence cord androgen levels differentially. Caution should be exercised when interpreting previously- ... This is the first study to report umbilical cord androgen levels in a large unselected population of neonates using LC-MS/MS. ... We performed a prospective cohort study of androgen concentrations in mixed arterial and venous umbilical cord serum from 803 ... Our findings suggest that previous studies have over-estimated cord androgen levels, and that fetal, maternal, ...
The factor circulates in the blood of newborns for about two weeks after birth and is not found in older babies or adults, ... When given to mice, the newly discovered factor countered signs of inflammation and sepsis, such as fever, fluctuations in ... A factor found in umbilical cord blood could become the basis for developing a new therapy to fight harmful inflammation, ... Yost and colleagues isolated a cord blood factor, called neonatal NET inhibitory factor (nNIF), based on its ability to inhibit ...
Astrocytes are cells found throughout the brain and spinal cord that normally support the nerve cells and keep them healthy. ... "Astrocytes are a wonderful target for spinal cord repair because they have potential to be either detrimental or supportive of ... The study, published yesterday (10/18) in the Journal of Neuroscience, shows that treating an injured adult spinal cord, by ... However, they say, strategies directed toward modification of the astrocyte response soon after a spinal cord injury represents ...
Transcription Factor Expression and Notch-Dependent Regulation of Neural Progenitors in the Adult Rat Spinal Cord. Shin-ichi ... Transcription Factor Expression and Notch-Dependent Regulation of Neural Progenitors in the Adult Rat Spinal Cord ... In contrast, we found that no cells expressing these factors emerged in the lesioned spinal cord (data not shown). Thus, the ... Expression of specific transcription factors in vivoin the adult spinal cord. The heterogeneity of adult progenitors in vivo ...
Participants were 490 people who took part in the health services module of the Swiss Spinal Cord Injury Cohort Study (SwiSCI) ... Prevalence of and factors associated with expressed and unmet service needs reported by persons with spinal cord injury living ... Spinal cord injury community survey: understanding the needs of Canadians with SCI. Top Spinal Cord Inj Rehabil. 2014;20:265-76 ... Spinal cord injury community survey: a national, comprehensive study to portray the lives of Canadians with spinal cord injury ...
... were measured using a specific radioimmunoassay for insulin-like growth factor (IGF)-I and a specific radioreceptor assay for ... Studies of insulin-like growth factor -I and -II by specific radioligand assays in umbilical cord blood Clin Endocrinol (Oxf). ... had effects on umbilical cord IGF-I concentrations. IGF-II concentrations were similar to adult values and did not correlate ... were measured using a specific radioimmunoassay for insulin-like growth factor (IGF)-I and a specific radioreceptor assay for ...
Because granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhance ... Granulocyte and granulocyte-macrophage colony-stimulating factors in cord and maternal serum at delivery Pediatr Res. 1994 Feb; ... Because granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhance ... We have used an ELISA to measure maternal and cord serum G-CSF and GM-CSF at the time of delivery, with gestational age between ...
What is Spinal Cord-Derived Growth Factor? Meaning of Spinal Cord-Derived Growth Factor medical term. What does Spinal Cord- ... Looking for online definition of Spinal Cord-Derived Growth Factor in the Medical Dictionary? Spinal Cord-Derived Growth Factor ... Spinal Cord-Derived Growth Factor , definition of Spinal Cord-Derived Growth Factor by Medical dictionary https://medical- ... redirected from Spinal Cord-Derived Growth Factor). Also found in: Acronyms. PDGFC. A gene on chromosome 4q32 that encodes ...
Umbilical cord blood has high levels of a factor, called neonatal NET inhibitory factor (nNIF), which inhibits a specific ... Yost and colleagues isolated a cord blood factor, called neonatal NET inhibitory factor (nNIF), based on its ability to inhibit ... A factor found in umbilical cord blood could become the basis for developing a new therapy to fight harmful inflammation, ... To test whether the cord blood factor could control sepsis, the scientists treated groups of mice in which the condition had ...
  • Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. (wikipedia.org)
  • There is evidence that cord factor is recognized by the Mincle receptor, which is found on macrophages. (wikipedia.org)
  • These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 adjuvanticity of TDM and TDB. (edu.au)
  • Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. (wikipedia.org)
  • Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. (wikipedia.org)
  • Furthermore, cord factor interlocks with lipoarabinomannan (LAM), which is found on the surface of M. tuberculosis cells as well, to form an asymmetrical bilayer. (wikipedia.org)
  • When cord factor is added back to those cells, M. tuberculosis survives at a rate similar to that of its original state. (wikipedia.org)
  • Specifically, cord factor on the surface of M. tuberculosis cells prevents fusion between phagosomal vesicles containing the M. tuberculosis cells and the lysosomes that would destroy them. (wikipedia.org)
  • Esterase activity that targets cord factor results in the lysis of M. tuberculosis cells. (wikipedia.org)
  • heat-killed cells with cord factor are unable to prevent being digested. (wikipedia.org)
  • Cord factor remains on the surface of M. tuberculosis cells until it associates with a lipid droplet, where it forms a monolayer. (wikipedia.org)
  • Numerous responses that vary in effect result from cord factor's presence in host cells. (wikipedia.org)
  • Induced pluripotent stem (iPS) cells that possess embryonic stem (ES) cell-like properties are generated through the use of the Yamanaka transcription factors, OCT4, SOX2, KLF4, and MYC (OSKM). (vt.edu)
  • Umbilical cord matrix mesenchymal stromal cells (MSC) were transduced with the non-integrating Sendai virus encoding for the OSKM transcription factors. (vt.edu)
  • The generation of iTr cells by transduction of the Yamanaka reprogramming factors is not unique to equine cells. (vt.edu)
  • Furthermore, fibrinogen has shown to adsorb to monolayers of cord factor and act as a cofactor for its biological effects. (wikipedia.org)
  • Cord factor increases the virulence of tuberculosis in mice, but it has minimal effect on other infections. (wikipedia.org)
  • The Australian Spinal Cord Injury Register is a collaborative activity of the AIHW National Injury Surveillance Unit and all of the specialist spinal units in Australia. (aihw.gov.au)
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