Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
An organophosphate insecticide that inhibits monoamine oxidase and acetylcholinesterase. It has been shown to be genotoxic.
Transplantation of an individual's own tissue from one site to another site.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Surgical insertion of cylindric hydraulic devices for the treatment of organic ERECTILE DYSFUNCTION.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Progenitor cells from which all blood cells derive.
Centers for collecting, characterizing and storing human blood.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
The return of a sign, symptom, or disease after a remission.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The transference of a part of or an entire liver from one human or animal to another.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Immunological rejection of leukemia cells following bone marrow transplantation.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Elements of limited time intervals, contributing to particular results or situations.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Disorders of the blood and blood forming tissues.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
The transference of a kidney from one human or animal to another.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Cells with high proliferative and self renewal capacities derived from adults.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
A general term for various neoplastic diseases of the lymphoid tissue.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Cells that can give rise to cells of the three different GERM LAYERS.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The transference of a heart from one human or animal to another.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.

Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. (1/440)

BACKGROUND AND PURPOSE: Human umbilical cord blood cells (HUCBC) are rich in stem and progenitor cells. In this study we tested whether intravenously infused HUCBC enter brain, survive, differentiate, and improve neurological functional recovery after stroke in rats. In addition, we tested whether ischemic brain tissue extract selectively induces chemotaxis of HUCBC in vitro. METHODS: Adult male Wistar rats were subjected to transient (2-hour) middle cerebral artery occlusion (MCAO). Experimental groups were as follows: group 1, MCAO alone (n=5); group 2, 3x10(6) HUCBC injected into tail vein at 24 hours after MCAO (n=6) (animals of groups 1 and 2 were killed at 14 days after MCAO); group 3, MCAO alone (n=5); group 4, MCAO injected with PBS at 1 day after stroke (n=8); and group 5, 3x10(6) HUCBC injected into tail vein at 7 days after MCAO (n=5). Rats of groups 3, 4, and 5 were killed at 35 days after MCAO. Behavioral tests (rotarod and Modified Neurological Severity Score [mNSS]) were performed. Immunohistochemical staining was used to identify cells derived from HUCBC. Chemotactic activity of ischemia brain tissue extracts toward HUCBC at different time points was evaluated in vitro. RESULTS: Treatment at 24 hours after MCAO with HUCBC significantly improved functional recovery, as evidenced by the rotarod test and mNSS (P<0.05). Treatment at 7 days after MCAO with HUCBC significantly improved function only on the mNSS (P<0.05). Some HUCBC were reactive for the astrocyte marker glial fibrillary acidic protein and the neuronal markers NeuN and microtubule-associated protein 2. In vitro, significant HUCBC migration activity was present at 24 hours after MCAO (P<0.01) compared with normal brain tissue. CONCLUSIONS: Intravenously administered HUCBC enter brain, survive, migrate, and improve functional recovery after stroke. HUCBC transplantation may provide a cell source to treat stroke.  (+info)

Listeriosis in recipients of allogeneic blood and marrow transplantation: thirteen year review of disease characteristics, treatment outcomes and a new association with human cytomegalovirus infection. (2/440)

Listeriosis is uncommon in recipients of allogeneic blood, marrow and organ transplantation. Six patients with systemic Listeria monocytogenes infection during 1985-1997 at Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center are described. In two male and four female patients, the median duration from transplantation to isolation of L. monocytogenes was 62.5 (range 29 to 821) days. Among five allogeneic marrow transplant recipients, four (80%) received HLA antigen matched, T cell-depleted grafts from three unrelated and a single related donor. One patient underwent mismatched-related marrow graft transplant. Cord stem cell transplantation was performed in a single patient. Two required therapy for graft-versus-host disease (GVHD). The 13 year incidence of systemic Listeria infections was 0.47 percent. All six presented with fever (>39 degrees C), and L. monocytogenes bloodstream invasion. Mental status changes and meningioencephalitis were observed in two (33.3%). A concurrent primary opportunistic infection was present in five individuals (83.3%), and four (80%) were being treated for acute human cytomegalovirus (HCMV) viremia. Sixty-six percent responded to therapy and two died from unrelated, non-listeric causes. Systemic listeriosis was uncommon in our high-risk allogeneic blood and marrow transplantation population, and response to therapy with parenteral ampicillin and gentamicin was excellent. The association between primary HCMV reactivation and subsequent listeric infection emphasizes the significance of HCMV-related dysfunction in hosts' cellular immune responses, especially in the setting of allogeneic transplantation.  (+info)

Human herpesvirus-6 encephalitis after unrelated umbilical cord blood transplant in children. (3/440)

Three children developed human herpesvirus-6 (HHV-6), variant B encephalitis after unrelated umbilical cord blood transplant, in a single center. They developed clinical manifestations of encephalitis around day 17 post transplant. Impairment of consciousness, incoherent speech, episodic focal pruritus, motor weakness, convulsions and severe hyponatremia were features at presentation. Radiological investigation of brain ranged from unremarkable to extensive white matter and meningeal lesions. Diagnosis was established by the presence of HHV-6 DNA in cerebrospinal fluid (CSF). Retrospective analyses of plasma revealed the presence of viral DNAemia prior to the onset of disease in two subjects. Treatment with ganciclovir or foscarnet was given. Two subjects did not achieve engraftment and died of other transplant-related complications on day 38 and 56 post-transplant, respectively. One subject achieved disease-free survival for more than 1 year with a satisfactory neurological outcome. In conclusion, HHV-6 encephalitis is not uncommon among patients undergoing umbilical cord blood transplantation. It is worth conducting further studies on early diagnosis and optimal management of this potentially fatal disease.  (+info)

Successful treatment of relapsed blastic natural killer cell lymphoma with unrelated cord blood transplantation. (4/440)

The prognosis for blastic natural killer (NK) cell lymphoma is generally dismal. We report a patient who was successfully treated with unrelated cord blood transplantation (UCBT). A 15-year-old boy was diagnosed as having blastic NK cell lymphoma in the cervical lymph nodes. Autologous peripheral blood stem cell transplantation was performed on achieving a complete remission. However, the disease recurred in the bone marrow 6 months later. Chemotherapy induced a second remission and the patient received UCBT with a conditioning regimen consisting of total body irradiation, thiotepa and cyclophosphamide. Chronic GVHD of the lung occurred, but it was well controlled with steroids. At the time of writing, he remains in remission 18 months after UCBT with an excellent performance status. UCBT may be an option for patients with blastic NK cell lymphoma.  (+info)

Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. (5/440)

In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after unrelated cord blood transplantation. Monitoring the BP-specific circulating antibodies and CD25-expressing activated T lymphocyte subset led us to combine anti-CD20 (Rituximab) mediated B cell ablation with anti-CD25 (Daclizumab) therapy to block CD4(+) T cell help. Complete clinical and serologic response was achieved within 4 weeks of initiation of therapy allowing global immunosuppression to be dramatically reduced.  (+info)

A successful liver transplantation for refractory hepatic veno-occlusive disease originating from cord blood transplantation. (6/440)

An 11-month-old boy with acute lymphoblastic leukemia (ALL) underwent umbilical cord blood transplantation (CBT) from an unrelated donor after a first complete remission. Despite the prophylactic use of low molecular weight heparin, prostaglandin E1 and ursodeoxycholic acid, hepatic veno-occlusive disease (VOD) occurred on the 29th day after CBT. Furthermore, neither defibrotide nor antithrombin-III improved the hepatic coma and coagulopathy due to the hepatic VOD. On the 42nd day after CBT, he underwent living related liver transplantation (LRLT) with a left lateral segment graft from his father. He received tacrolimus for the prevention of rejection and graft-vs.-host disease (GVHD) and also received aggressive antifungal and antiviral prophylaxis. Although he showed signs of acute rejection on postoperative days 5 and 10, the postoperative course was uneventful in general. At present, 17 months after LRLT, the patient shows stable liver function and no signs of either GVHD or a relapse of ALL. In conclusion, LRLT can be seen as a feasible option for the treatment of a hepatic VOD after CBT, though aggressive prophylaxis for infection and the anticipation of acute rejection are of importance.  (+info)

"Saviour siblings". (7/440)

The Victorian Infertility Treatment Authority has given permission to allow tissue typing in combination with preimplantation genetic diagnosis. This is a new application of IVF. Not only will it allow parents to select an embryo free from serious genetic disease it will allow them to simultaneously select for a match so that the umbilical cord blood of the resulting baby can provide stem cells to treat an existing sibling who has a disease.  (+info)

Induction of graft-versus-host disease and a graft-versus-leukemia effect using ubenimex in a patient with infantile leukemia relapsing after an unrelated cord blood transplant. (8/440)

A 20-month-old boy with infantile leukemia was treated with total body irradiation, etoposide, cyclophosphamide and unrelated cord blood transplantation with a one-antigen mismatch. He relapsed on day 100 and achieved remission after ubenimex administration, and also developed chronic graft-versus-host disease of the skin. He remained in remission for 22 months with repeated courses of ubenimex. Ubenimex may be an alternative to donor lymphocyte transfusion and may be useful for the treatment of a patient who has relapsed after cord blood transplantation.  (+info)

Banking and Transplantation of Unrelated Donor Umbilical Cord Blood: Status of the National Heart, Lung, and Blood Institute-Sponsored ...
This phase II trial is studying how well umbilical cord blood transplant from a donor works in treating patients with hematological cancer. Giving chemotherapy and total-body irradiation (TBI) before a donor umbilical cord blood transplant helps stop the growth of cancer and abnormal cells and helps stop the patients immune system from rejecting the donors stem cells. When the healthy stem cells from an unrelated donor, that do not exactly match the patients blood, are infused into the patient they may help the patients bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the bodys normal cells (called graft-versus-host disease). Giving cyclosporine and mycophenolate mofetil before and after transplant may stop this from happening ...
This phase II trial is studying how well umbilical cord blood transplant from a donor works in treating patients with hematological cancer. Giving chemotherapy and total-body irradiation (TBI) before a donor umbilical cord blood transplant helps stop the growth of cancer and abnormal cells and helps stop the patients immune system from rejecting the donors stem cells. When the healthy stem cells from an unrelated donor, that do not exactly match the patients blood, are infused into the patient they may help the patients bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the bodys normal cells (called graft-versus-host disease). Giving cyclosporine and mycophenolate mofetil before and after transplant may stop this from happening ...
Double-Unit Cord Blood Transplantation Not Superior to Single-Unit in Reducing Risk of Transplant Failure in Children and Young Adults - From the Blood Journals, News, Written in Blood - ASH Clinical News
We describe outcomes of a large series of predominantly small and young children with IMDs belonging to the lysosomal and peroxisomal disorders who underwent transplantation with UCBT at a single center after uniform cytoreduction and were followed for 1 to 11 years (median, 4.6 years). Important variables improving OS significantly were better performance status (P , .001), higher infused CFUs (P = .02), and matched ethnicity between the CBU and the recipient (P = .05). The cumulative incidence (87.1% by day 42) and speed (median, day 22) of neutrophil engraftment was higher and faster than previously reported in large cohort studies.27,28,42 Most patients (97%) achieved and sustained full donor chimerism (, 90%) and normalized enzyme levels where measurable. This high level of donor chimerism is better than those reported in the literature after unrelated bone marrow transplantation. Although detailed, disease-specific outcomes are not fully described in this report; all surviving children ...
This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide (CY), fludarabine phosphate (FLU), and total-body irradiation (TBI) works in treating patients with hematologic disease.. Giving chemotherapy, such as CY and FLU, and TBI before a donor umbilical cord blood transplant helps stop the growth of cancer and abnormal cells and helps stop the patients immune system from rejecting the donors stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patients bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the bodys normal cells. Giving cyclosporine and mycophenolate mofetil after transplant may stop this from happening.. ...
This study is currently recruiting participants. Verified June 2012 by Fred Hutchinson Cancer Research Center First Received on July 25, 2008. …
Unrelated umbilical cord blood stem cell transplant after failure of haploidentical or matched unrelated donor hematopoietic stem cell transplant.
TY - JOUR. T1 - Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. AU - Joseph, Matthew. AU - Das, Manjusri. AU - Kanji, Suman. AU - Lu, Jingwei. AU - Aggarwal, Reeva. AU - Chakroborty, Debanjan. AU - Sarkar, Chandrani. AU - Yu, Hongmei. AU - Mao, Hai Quan. AU - Basu, Sujit. AU - Pompili, Vincent J.. AU - Das, Hiranmoy. PY - 2014/10. Y1 - 2014/10. N2 - Despite recent advances in cardiovascular medicine, ischemic diseases remain a major cause of morbidity and mortality. Although stem cell-based therapies for the treatment of ischemic diseases show great promise, limited availability of biologically functional stem cells mired the application of stem cell-based therapies. Previously, we reported a PES-nanofiber based ex vivo stem cell expansion technology, which supports expansion of human umbilical cord blood (UCB)-derived CD133+/CD34+ progenitor cells ~225 fold. Herein, we show that using similar ...
Objective The aim of the study was to evaluate the efficacy and safety of umbilical cord blood stem cells (USCs) transplantation combined with routine supportive therapy (RST) for liver cirrhosis (LC). Materials and methods Clinical trials involved in this research were searched from Web of Science, PubMed, EMBASE, Cochrane Library, Wanfang and CNKI database. Treatment effects, quality of life (QoL), adverse events and other outcome measures were extracted and evaluated. Results A total of 10 trials including 616 LC patients were involved in this study. Based on our analysis, the liver function of LC patients was significantly improved after USCs transplantation and RST combined therapy, indicated by decreased total bilirubin, alanine aminotransferase, aspartate aminotransferase levels and prothrombin time and increased serum albumin level and prothrombin activity. Compared to those treated by RST alone, patients treated by combined therapy
In a new peer-reviewed article published by the Journal of Translational Medicine, scientists from Beike Biotechnology,Chinas leading stem cell research and regenerative medicine company, and Medistem, Inc.,reported positive safety data in 114 patients who were treated by doctors at Nanshan Affiliated Hospital of Guangdong Medical College (Shenzhen Nanshan Hospital) in Shenzhen using Beikes proprietary cord blood stem cell transplantation protocol.
We studied the effect of the inter-unit HLA match on outcomes of double UCB transplantation for acute leukemia and did not find an association between inter-unit HLA-mismatch and outcomes. Specifically, there were no differences in hematopoietic recovery, acute GvHD or survival, demonstrating that inter-unit HLA-match is not relevant when selecting UCB units for double UCB transplantation for acute leukemia. The only unit characteristic associated with neutrophil recovery was cell dose. Transplantations of UCB units with a combined infused TNC 4×107/kg or more was associated with faster neutrophil recovery, but infused TNC was not associated with survival or non-relapse mortality. There were no differences in engraftment of the dominant and non-dominant units based on inter-unit HLA match or unit TNC within the first month after transplantation. Our observations are not in keeping with a single report of early engraftment of the non-dominant UCB unit when the cell dose of the dominant unit was ...
Our goal is to increase the number of immature umbilical cord blood stem cells (UCBSCs) for hematopoietic transplantation. Towards this goal, our lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ cells). Although CD133+ cells proliferate rapidly in culture, a minority self-renew and remain CD133+, while a majority differentiate and become CD133-. Therefore, new strategies to identify and grow immature UCBSCs are important. Since little is known about signally mechanisms regulating self-renewal and differentiation of UCBSCs, we sought insight from embryonic stem cell (ESC) literature to guide our studies. \r\nTo identify a population of UCBSCs that grow without differentiating, we focused on Oct-4, a transcription factor essential for self-renewal in ESCs that we previously reported expression in UCBSCs. During our studies, new challenges in the field arose. Two isomers of Oct-4 were discovered, Oct-4A and Oct-4B 3, in which only Oct-4A conferred the ability of ESCs to ...
This retrospective study aimed to assess the safety of patients with severe cerebral palsy (CP), who received allogeneic umbilical cord blood stem cells (UCBSCs) treatment from August 2009 to December 2012 in Guangdong Provincial Hospital of Chinese Medicine. A total of 47 patients with average age …
Umbilical Cord Blood Stem Cells Current Status & Future Potential Natasha Ali Assistant Professor Haematology Department of Pathology & Laboratory Medicine/Oncology The Aga Khan University
ORLANDO, Florida, January 30 /PRNewswire/ -- John Wagner, M.D., recognized as a leader in the field of cord blood stem cell transplantation, has joined the team at CORD:USE Cord Blood Bank. Dr. Wagners extensive experience and knowledge in transplant medicine and stem cell biology will provide a significant contribution to CORD:USE.
TY - JOUR. T1 - Concurrent acute necrotizing adenovirus hepatitis and enterocolitis in an adult patient after double cord blood stem cell transplant for refractory. AU - Disease, Crohns. AU - Lo, Amy A.. AU - Lo, Edward C.. AU - Rao, M. Sambasivia. AU - Yang, Guang Yu. PY - 2015/5/1. Y1 - 2015/5/1. N2 - It has been recently recognized that adenovirus is a pathogen with high morbidity and mortality among immunocompromised patients, particularly after solid organ or stem cell transplant. Confluent necrotizing hepatitis secondary to adenovirus infection alone or together with other organ involvement is extremely rare. There are only 32 cases of confluent necrotizing hepatitis reported in adults since 1960 and most occur after iatrogenic immunosuppression for bone marrow or solid organ transplantation or in other states of immunosuppression, including acquired immunodeficiency syndrome or chemotherapy treatment. We present the first case of concurrent adenovirus-induced necrotizing hepatitis and ...
The main purpose of this investigational (not approved by the FDA) Phase I research is to test whether transplantation of umbilical cord blood cells can
Our data indicate that UCBT is an excellent option for children with hereditary bone marrow failure syndromes when the donor is an HLA-matched sibling donor. Our results are in agreement with those of a previously published analysis which compared outcome of patients undergoing HLA-identical sibling UCBT with that of HLA-identical sibling bone marrow transplant recipients and showed similar overall survival in children with malignant and non-malignant diseases.16 Banks of related cord blood have been established; they are not, however, sufficiently developed despite the excellent results observed not only in marrow failure but also in other hereditary disorders such as hemoglobinopathies, metabolic disorders and congenital immune deficiencies.17,18 Another factor in favor of freezing cord blood cells from an HLA-identical sibling is the absence of risk for the donor.. An important observation is that the risk of graft failure after unrelated UCBT was high in this cohort of patients. The risk of ...
Promising results of umbilical cord blood transplantation (UCBT) from unrelated donors have been reported in patients with hematologic disorders. These transplants, having potential to trigger beneficial donor-versus-recipient natural killer (NK) cell-mediated alloreaction, we have conducted the fir …
Background: Measures were introduced in both the House and Senate to establish a National Cord Blood Stem Cell Bank Network.. Umbilical cord blood stem cells are obtained from the blood contained in the delivered placenta and umbilical cord, which are normally discarded after childbirth. Obtaining these stem cells presents no inherent moral concerns. Through freezing they can be preserved for many years.. According to findings presented in the House measure, cord blood stem cell transplants can be used for bone marrow reconstitution to treat malignancies such as leukemia and lymphoma, genetic disorders such as sickle cell anemia, and acquired diseases. The findings also claim that cord blood stem cells do not have to be matched as closely as bone marrow transplants. This means patients will be more likely to find a suitable unrelated cord blood donor than a matched bone marrow donor. Supporters say a network of at least 150,000 units of ethnically balanced cord blood donors would provide ...
Cell dose is a critical determinant of outcomes in unrelated cord blood (CB) transplantation. We investigated a strategy in which CB units should contain at least 2 × 107 total nucleated cells/kg of recipient weight, otherwise a second unit had to be added. We report the results of a study that was prematurely closed owing to toxicity. Patients with advanced hematologic malignancies without a human leukocyte antigen-matched sibling or unrelated donor were eligible. Conditioning regimen consisted of fludarabine and 12 Gy of total body irradiation (n=11), or melphalan (n=4), with antithymocyte globulin. Graft-versus-host disease prophylaxis was tacrolimus and methotrexate. Fifteen patients with acute leukemia (n=9), chronic myelogenous leukemia (n=2), multiple myeloma (n=2) and lymphoma (n=2) were treated; 60% had relapsed disease at transplantation. Three patients received double CB transplants. The 100-day and 1-year treatment-related mortality rates were 40 and 53%, respectively. Median time to
ATLANTA —Twelve percent of adults with acute myeloid or acute lymphoblastic leukemia who received umbilical cord blood transplantation experienced graft failure, according to a large European retrospective study presented at the ASH Annual Meeting and Exposition.“Our aim was to assess the outcomes of patients with acute leukemia who experience graft failure after umbilical cord blood
Clinical trial for Pediatric Patients Undergoing Allogeneic Cord Blood Transplantation. , Eltrombopag for Enhancing Platelet Engraftment in Pediatric Patients Undergoing Cord Blood Transplantation
... ORLANDO Fla. Jan. 30 /- John Wagner M.D. recogniz... Were honored and fortunate to have him as a member of ourdistinguis...Dr. Wagner is internationally recognized as an expert in the field of...Dr. Wagner has played a considerable role in the development andexpan...,CORD:USE,Cord,Blood,Bank,Announces,the,Addition,of,Dr.,John,Wagner,,a,Pioneer,in,the,Use,of,Umbilical,Cord,Blood,Stem,Cells,,to,Its,Scientific,Advisory,Board,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
This clinical trial studies intra-osseous donor umbilical cord blood and mesenchymal stromal cell co-transplant in treating patients with hematologic malignancies. Giving low doses of chemotherapy and total-body irradiation before a co-transplant of donor umbilical cord blood and mesenchymal stromal cells into the bone (intra-osseous) helps stop the growth of cancer cells. It may also stop the patients immune system from rejecting the donors stem cells. The donated stem cells may replace the patients immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect).
Haematopoietic stem cell transplants have been performed for more than 50 years and have been used to treat more than 80 life-threatening diseases
Stem cells hold the promise of treatments and cures for more than 70 major diseases.Dating back to the worlds first successful bone marrow transplant in 1968, the University of Minnesota Medical School has been, and continues to be, a leader in stem cell research and regenerative medicine-a field of innovative therapies that enable the body to heal itself.Now with new discoveries being made, were working on cures for everything from diabetes to dementia. The Medical Schools blood and marrow transplant research has a legacy of changing perspectives around what is medically possible for children battling some of the worlds most complex, life-threatening diseases. Beyond the first successful bone marrow transplant (BMT) in the world, the Medical School has a history of firsts, including:The first transplant to treat a patient with lymphoma (1975)The first transplant to treat an inherited metabolic disease (1982)The first double umbilical cord blood transplant (1999)The first umbilical cord blood
Montclair, NJ: cord blood stem cells. Umbilical cord blood banking in New Jersey is an amazing frontier of medical science - find out everything here!
Key Points. CBT after FLU-CY-ATG-2-Gy TBI with at least 4 × 107 frozen NCs per kilogram leads to satisfactory OS in refractory SAA.CBT is a valuable curative op
TY - JOUR. T1 - Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy. AU - AML and MDS Working Group of the Japan Society for Hematopoietic Cell Transplantation. AU - Arai, Yasuyuki. AU - Takeda, June. AU - Aoki, Kazunari. AU - Kondo, Tadakazu. AU - Takahashi, Satoshi. AU - Onishi, Yasushi. AU - Ozawa, Yukiyasu. AU - Aotsuka, Nobuyuki. AU - Kouzai, Yasuji. AU - Nakamae, Hirohisa. AU - Ota, Shuichi. AU - Nakaseko, Chiaki. AU - Yamaguchi, Hiroki. AU - Kato, Koji. AU - Atsuta, Yoshiko. AU - Takami, Akiyoshi. PY - 2015/7/16. Y1 - 2015/7/16. N2 - Cord blood transplantation (CBT) is an effective therapeutic option for adults with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after the conventional cyclophosphamide and total body irradiation (CY/TBI) regimen, but posttransplant relapse is still of high importance. High-dose cytarabine (HDCA) can be added to CY/TBI for an intensified regimen; however, its additional effects have ...
The results of a small clinical trial offer a way to make umbilical cord blood transplants for leukemia and lymphoma more effective.
You are being asked to take part in this study because you are going to have a cord blood transplant and one or more of the cord blood units that are considered by your doctor to be the best choice for your transplant may not meet all the new FDA standards. This study will allow your doctor to use these cord blood units for your transplant. Cord blood units used for transplant on this study must meet standards set by the NMDP. If a cord blood unit meets NMDP standards this means that the cord blood unit is suitable for use. This does not however guarantee that the cord blood units(s) will be successful in treating your disease ...
Front Pharmacol. 2017 Sep 8 Human Umbilical Cord Blood Cell Transplantation in Neuroregenerative Strategies. Galieva LR1, Mukhamedshina YO1,2, Arkhipova SS1, Rizvanov AA1. Author information Abstract At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC),
Diabetes mellitus (DM) instigates a cascade of events leading to vascular damage and poor recovery after ischemic stroke. Our previous studies have found that treatment of stroke with bone-marrow-stromal cells initiated at 24h after stroke improves functional recovery in non-DM rats, but not in DM rats. Effective therapy for stroke in the non-DM population may not necessarily transfer to the DM population, prompting the need to develop therapeutic approaches specifically designed to reduce neurological deficits after stroke in the DM population. In this study, we hypothesize that treatment of stroke with human umbilical cord blood cells (HUCBCs) promotes neurorestorative effect in DM rats.. Methods: Type one DM (T1DM) was induced with a single injection of streptozotocin (60 mg/kg, ip) to adult male Wistar rats. These rats were subjected to 2h MCAo and were randomized to intravenous injection via tail-vein with: 1) phosphate-buffered saline control; 2) HUCBCs (5x106) at 24 hours after MCAo. A ...
As most parents would like to bank their babies cord blood to help safeguard their families, it is often the cost of cord blood banking that is the one reason why they do not. Most cord blood banks have an upfront fee for collecting, processing and cryo-preserving the cord blood that runs between $1,000 and $2,000. This upfront fee often also includes the price of the kit provided to collect and safely transport the cord blood, the medical courier service used to expedite the kits safe shipment, the testing of the mothers blood for any infectious diseases, the testing of the babys blood for any contamination, and the cost of the first full year of storage. There is then often a yearly fee on the babys birthday for continued storage that runs around $100 to $200 a year ...
As noted, there are different ways to process cord blood, and although the type of processing method doesnt always enter the conversation on cord blood banking, it is a big part of the purity of any cord blood collection. Red blood cells can have a negative impact on a cord blood transfusion. In addition, there is a certain number of stem cells that need to be present in order for the cord blood to be effective in disease treatment. Each processing method has the ability to better reduce the number of RBCs and capture more stem cells. Some processing methods like AutoXpress and Sepax are automated to ensure a level of consistency across all collections. HES is preferred by some banks because it was the original processing method used by most banks and it has a proven track record. You can read more about the different cord blood processing methods here ...
Although cord blood is currently considered discarded human material, it should only be collected for banking with an institutional review board-approved protocol and with signed informed consent from a parent.42,43 Pertinent donor information communicated to the cord blood bank should be kept confidential by the cord blood bank and used only to report important medical information obtained during the cord blood collection, processing, and screening process that is relevant to the safety of the donor and family. If cord blood was collected from a newborn who subsequently developed a genetic, immunologic, or malignant neoplastic disorder, parents should notify the cord blood bank so that the unit is not used for transplantation. All cord blood units banked for potential use should be tested for infectious diseases, similar to those tested in a blood bank, and for hereditary hematologic diseases. The informed consent must contain information pertaining to what tests are to be performed on the cord ...
In the United States, approximately 15 percent of children suffer from low or high-frequency hearing loss.[i] The most common type of hearing loss, especially at high frequencies, is sensorineural. Acquired sensorineural hearing loss results from damage to hair cells in the inner ear (cochlea) and can be caused by illness, medication, noise exposure, birth injury, or head trauma. A childs ability to hear affects the development of language skills, and hearing impairments can lead to poor academic and social development.[ii]. The groundbreaking phase 1 study has a primary objective of determining the safety of using cord blood stem cells in a select pediatric patient population while also assessing whether this approach to treatment improves inner ear function, speech, and language development. Researchers will follow 10 children, ranging in age from 6 weeks to 6 years, who have been diagnosed with acquired hearing loss for less than 18 months and who have their own cord blood unit processed and ...
Umbilical cord blood (UCB) is an alternative hematopoietic stem cell (HSC) source that can ameliorate several diseases through transplantation. The purpose of this project is to analyze clinical studies comparing HSCs from a single cord blood unit (CBU) to HSCs from bone marrow, and to explore methods of increasing limited amounts of HSCs. It was found that UCB transplantation in adults is a viable method when a matched bone marrow transplant cannot be identified. Further clinical studies using two CBUs suggest better engraftment and lower risk of relapse. However, double cord blood transplantation has been faced with the challenge of single unit dominance in most studies. Ex vivo expansion of UCB HSCs is another promising method to overcome limited HSC counts.
It makes more sense to donate】. Base on the current development of biomedical science, AAP discourage saving umbilical cord blood as a life insurance, because there are no scientific data as of now to support the use of autologous cord blood transplant. Though theoretically possible, we are uncertain whether the theory will become practice at all, or when exactly will this technology be adopted. Most private banks prey on the parents fear of the unknown future, knowing how vulnerable the parents are to the emotional effects of the marketing of cord blood banking. They advertise the many possibility as a reality despite there being a lot of uncertainties still.. Contrarily, there are many successful cases of allogeneic cord blood transplantation. In such cases, the stem cells transplanted are from other individuals. Majority of these stem cell transplants have been done using samples from public banks because a perfect match is not required for cord blood transplantation. This also shows why ...
by APFLI , Feb 2, 2006 , Stem Cell Research & Cloning. www.ClinicalTrials.gov - Amazing list of over 250 grants through NIH; at least half deal with non-embryonic stem cell research. http://www.clinicaltrials.gov/ct/search?term=%22stem+cells%22&submit=Search With patients own cells, heart vessels and tissue show mending http://www.chron.com/cs/CDA/ssistory.mpl/metropolitan/3277225 Check the Score http://stemcellresearch.org/ Diseases Treated Now with Cord Blood Stem Cells http://www.viacord.com/what_diseases_treated.htm Why Cord Blood is the Premier Source of Stem Cellshttp://www.viacord.com/what_why_premier_source.htm Adult & Umbilical Cord Blood Stem Cell Research Breakthroughs, Treatments and Cures as of 4/05 Spinal Cord Injuries - olfactory glial cells from the lining of the patients nose (1,2) or from umbilical cord stem cells (3) Skull Bone Repair - girls own bone and adult stem cells to repair 19 sq in. of her skull (4) Liver Repair - adult stem cells (5) Heart Muscle Regeneration - ...
by APFLI , Feb 2, 2006 , Stem Cell Research & Cloning. www.ClinicalTrials.gov - Amazing list of over 250 grants through NIH; at least half deal with non-embryonic stem cell research. http://www.clinicaltrials.gov/ct/search?term=%22stem+cells%22&submit=Search With patients own cells, heart vessels and tissue show mending http://www.chron.com/cs/CDA/ssistory.mpl/metropolitan/3277225 Check the Score http://stemcellresearch.org/ Diseases Treated Now with Cord Blood Stem Cells http://www.viacord.com/what_diseases_treated.htm Why Cord Blood is the Premier Source of Stem Cellshttp://www.viacord.com/what_why_premier_source.htm Adult & Umbilical Cord Blood Stem Cell Research Breakthroughs, Treatments and Cures as of 4/05 Spinal Cord Injuries - olfactory glial cells from the lining of the patients nose (1,2) or from umbilical cord stem cells (3) Skull Bone Repair - girls own bone and adult stem cells to repair 19 sq in. of her skull (4) Liver Repair - adult stem cells (5) Heart Muscle Regeneration - ...
Newborn Blood Banking stores umbilical cord blood stem cells as an alternative to bone marrow. We store whole blood to maximize the number of stem cells.
Newborn Blood Banking stores umbilical cord blood stem cells as an alternative to bone marrow. We store whole blood to maximize the number of stem cells.
Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication ...
Although pharmacological methods for treating AD have been discovered, none significantly delay the progression of the disease. However, cell transplantation research using animals modeled with AD has indicated that human umbilical cord blood cells (HUCBCs) can ameliorate some cognitive deficits and reduce the effects of the amyloid-beta (Aβ) plaques, one of the physiological hallmarks of AD, comprised of peptides of 36-43 amino acids. However, the role that HUCBCs play in Aβ clearance has yet to be elucidated ...
There are several advantages of using umbilical cord blood stem cells over bone marrow stem cells for transplants (see Table 2). The first advantage is that umbilical cord blood is relatively easy to collect and process. Once considered a substance to be thrown away after a birth, now the cord blood can be easily saved. After it is saved and sent to a storage facility, the cord blood is quickly available for use within days to weeks after processing. In contrast, bone marrow stem cells can take much longer to find a match, collect the sample, and process. The process for bone marrow transplantation can take from weeks to months. The collection process for cord blood is not painful to either mother or child and can be done either prior to or after the delivery of the placenta (Gonzalez-Ryan, VanSyckle, Coyne, & Glover, 2000; Percer, 2009). Bone marrow transplants, on the other hand, require the donor to be hospitalized, anesthetized, and experience postcollection pain and discomfort. Thus, ...
OBJECTIVE We examined the therapeutic strategies for treating mild gastrointestinal (GI) graft-versus-host disease (GVHD) using oral beclomethasone dipropionate (BDP) in 15 Japanese patients based on the donor source. The primary objective was to determine the efficacy and toxicity of oral BDP combined with/without low-dose prednisone (PSL). METHODS Oral BDP was administered with 1 mg/kg/d of PSL in patients undergoing bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT; n=11), and the dose of PSL was tapered off after 22 days. Oral BDP alone was administered in patients undergoing cord blood stem cell transplantation (CBSCT; n=4). The primary endpoint was the rate of treatment success on day 49, as measured according to the improvement or complete resolution of GI symptoms without additional treatment. The secondary endpoints included treatment-related toxicity according to the National Cancer Institute Common Toxicity Criteria version 3.0, the rate of treatment
Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white-matter injury than stroke in non-DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type-2 diabetes (T2DM). db/db-T2DM and db/+-non-DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non-DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve-HUCBC; (d) T2DM + miR-126(-/-) HUCBC. Functional evaluation, vascular and white-matter changes, neuroinflammation, and miR-126 effects were measured in vivo and in vitro. T2DM mice exhibited significantly decreased serum and brain tissue miR-126 expression compared with non-DM mice. T2DM + HUCBC mice exhibited increased miR-126 expression, increased tight junction protein expression, axon/myelin, vascular density, and M2-macrophage polarization. However, decreased blood-brain barrier leakage, brain hemorrhage, and miR
American Cancer Society: Bone Marrow and Peripheral Blood Stem Cell Transplants - The American Cancer Society is the nationwide community-based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives, and diminishing suffering from cancer, through research, education, advocacy, and service. Learn the basics and read the transplant process at this site.. The Bone Marrow Foundation - The mission of The Bone Marrow Foundation is to improve the quality of life for bone marrow and stem cell transplant patients and their families by providing financial aid, education and emotional support.. BMT InfoNet - Blood & Marrow Transplant Information Network is a not-for-profit organization dedicated exclusively to serving the needs of persons facing a bone marrow, blood stem cell or umbilical cord blood transplant. Here you will find support services, a drug database and more.. Cancer.Net: Understanding Bone Marrow and Stem Cell ...
Chatchada Karanes, M.D., is a hematologist/oncologist at City of Hope specializing in stem cell transplantation with an emphasis on the use of umbilical cord blood transplants to treat a growing number of blood cancers.
A bone marrow transplant is a treatment option for some people who have life-threatening blood or immune system diseases, such as leukaemia, multiple myeloma and lymphoma. The procedure replaces blood stem cells in people whose bone marrow has been destroyed by large doses of chemotherapy or radiotherapy.. A bone marrow transplant is a generic term that covers all types of transplants that use stem cells: a blood stem cell transplant, an umbilical cord blood transplant and a bone marrow transplant.. There are different types of bone marrow transplants:. ...
Umbilical cord blood is taken from a new-borns umbilical cord and placenta immediately following birth - a painless, risk-free procedure. Cord blood contains a high concentration of stem cells, and recent studies have shown it provides unique advantages over traditional bone-marrow transplantation. The most significant advantage is that the donor cord blood stem cells do not have to match 100% to the recipients tissue, making finding a suitable match easier.. Cord blood can be used for the baby, the brothers and sisters and the mom and dad with a suitably matching tissue type, and in these instances cord blood stem cell transplants can in fact prove life-saving.. Much like cord blood, umbilical cord tissue can also be collected and stored in a stem cell bank. Cord tissue Mesenchymal stem cells (MSCs) are younger and considered a superior resource when compared to bone marrow MSCs as they are younger and subsequently, they have greater differentiation potential and faster rates of ...
Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ) focused on bringing the life saving
HONG KONG, July 23, 2014 /PRNewswire-FirstCall/ - China Cord Blood Corporation (NYSE: CO) (CCBC or the Company), Chinas leading provider of cord blood collection, laboratory testing, hematopoietic stem cell processing, and stem cell storage services, and Cordlife Group Limited (Cordlife), a multi-product healthcare company catering to the mother and child segment, today announced that the two companies have joined forces in assisting patients across the PRC, Singapore, Hong Kong, Indonesia, India, the Philippines and Malaysia to identify suitable cord blood matching units for stem cell therapy. Under the Memorandum of Understanding signed between the two companies, Cordlife, on behalf of its patients who are in need of cord blood stem cell therapy, can facilitate the process by providing relevant information to CCBC, who will then perform searches for possible matching units among its donated cord blood samples in the PRC. For patients who reside in the PRC, CCBC may seek Cordlifes ...
Since 1988, allogeneic cord blood transplantations have been used in the hematology and oncology area. Cord blood banks, either public or from non-profit corporations, opened in several countries. They organized themselves into a world-wide network permitting broad and quick graft availability all over the world. Cryopreservation modalities and biological safety were strongly defined according to laboratory good practices. More recently, in the United States, Canada and some European and Asian countries, commercial companies created for-profit cord blood banks. They offer families the possibility of privately storing the cord blood of their children. Then, if a child gets sick and needs a hematopoietic stem cell transplantation, it is possible to use the cord blood for an autograft. These companies present this service, relatively expensive for the families, as a true biological insurance. Also, they capitalize on families hopes that scientific progress will increase cord blood autografts and ...
It is wonderful to pretend that supporters of embryonic stem cell research oppose funding of other types of research, but it is patently a lie. It is generally only those who oppose embryonic stem cell research who oppose funding of any particular type of stem cell research. ...
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Therapeutic Benefit of Treatment of Stroke with Simvastatin and Human Umbilical Cord Blood Cells: Neurogenesis, Synaptic Plasticity and Axon Growth
Rizvanov, AA., Guseva, DS., Salafutdinov, II., Kudryashova, NV., Bashirov, FV., Kiyasov, AP., Yalvaç, ME., Gazizov, IM., Kaligin, MS., Sahin, F., Mukhamedyarov, MA., Palotás, A., Islamov, RR. Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice. Exp Biol Med. 236 (1):91-98. 2011 ...
Upon birth, umbilical cord blood is taken and used for hematopoietic stem cell transplantation. In the United Kingdom, the ... A savior sibling may be the solution for any disease treated by hematopoietic stem cell transplantation. It is effective ... that can best be treated by hematopoietic stem cell transplantation. The savior sibling is conceived through in vitro ... A savior baby or savior sibling is a child who is conceived in order to provide an organ or cell transplant to a sibling that ...
... is amongst the diseases treated with bone marrow transplantation and cord blood stem cells.[citation needed] WHIM ... Myelokathexis is a congenital disorder of the white blood cells that causes severe, chronic leukopenia (a reduction of ... Blood. 95 (1): 320-327. doi:10.1182/blood.V95.1.320. PMID 10607719. Hord, JD; Whitlock, JA; Gay, JC; Lukens, JN (Sep-Oct 1997 ... circulating white blood cells) and neutropenia (a reduction of neutrophil granulocytes). The disorder is believed to be ...
... and not pluripotent stem cells (such as embryonic stem cells, which can differentiate into any type of tissue). Cord blood has ... hematopoietic cell transplantation stem cell transplantation (4th ed.). Oxford: Wiley-Blackwell. ISBN 9781444303537. Haller M J ... Along with cord blood, Wharton's jelly and the cord lining have been explored as sources for mesenchymal stem cells (MSC), and ... Any such potential beyond blood and immunological uses is limited by the fact that cord cells are hematopoietic stem cells ( ...
Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. ... Hematopoietic stem cells give rise to blood cells. Differentiation and proliferation of hematopoietic stem cells require a lot ... Stem cells are taken from an affected child's blood or bone marrow. Then in laboratory conditions the stem cells are ... Hematopoietic stem cell transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged ...
It procures, processes and stores human umbilical cord blood and tissue samples that may be used for stem cell treatments. ... There have been more than a million hematopoietic stem cell transplantations in the world as of December 2012. Cells4Life ... CS1 maint: discouraged parameter (link) "5 things to think about when banking your baby's stem cells". Cord Blood Aware. 29 ... CS1 maint: discouraged parameter (link) "New cord blood stem cell collection service in Maternity". Epsom and St Helier ...
Treatment options are limited, although hematopoietic stem cell transplantations using bone marrow or cord blood seem to help ... Induced pluripotent stem cells, oligodendrocyte precursor cells, gene correction, and transplantation to promote the maturation ... Oligodendrocyte precursor cells and neural stem cells have been transplanted successfully and have shown to be healthy a year ... disrupted with hematopoietic stem cell gene therapy but the exact reason why demyelination stops and the amount of stem cells ...
... or umbilical cord blood.[1][2] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ... Peripheral blood stem cells[25] are now the most common source of stem cells for HSCT. They are collected from the blood ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ...
It is also used before hematopoietic stem cell transplantation, because blood group incompatibility can be responsible for some ... 141 Cord blood samples may be contaminated with Wharton's jelly, a viscous substance that can cause red blood cells to stick ... two populations of red blood cells are apparent after reaction with the blood typing antisera. Some of the red blood cells are ... In blood typing, reagents containing blood group antibodies, called antisera,:586 are added to suspensions of blood cells. If ...
Only Hematopoietic Stem Cell Transplantation (HSCT), commonly referred to as a bone marrow or (umbilical) cord blood transplant ... high white blood cell count in blood), absolute monocytosis (high monocyte count in blood), anemia (low red blood cell count in ... Immature granulocytes and nucleated red cells in the peripheral blood. White blood cell count >10 x 109/L. Clonal chromosomal ... The only treatment that has resulted in cures for JMML is stem cell transplantation, also known as a bone marrow transplant, ...
It is also used before hematopoietic stem cell transplantation, as it may be responsible for some cases of acute graft-versus- ... Blood compatibility testing is also routinely performed on pregnant women and on the cord blood from newborn babies, because ... We identified ABCB6 as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma ... doi:10.1182/blood-2018-11-833954. ISSN 0006-4971. PMID 30808639. Dean, Laura (2005). Blood Groups and Red Cell Antigens. ...
June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... new methods have reduced culture time to 10-12 days by using specific cytokines from adult donors or virus-naive cord blood. ... cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ...
"Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117 (10): 2791-9. doi:10.1182/blood- ... StemCyte began collaborations with Cord blood banks worldwide to systematically screen Umbilical cord blood samples for the ... "Progress toward curing HIV infection with hematopoietic cell transplantation". Stem Cells and Cloning: Advances and ... Recent studies suggest that CCR5 is expressed in a subset of cancer cells with characteristics of cancer stem cells, which are ...
This usually takes the form of a bone-marrow transplantation, but the cells can also be derived from umbilical cord blood. ... Fetal tissue implant Induced pluripotent stem cell Induced stem cells Stem cell chip Mahla RS (2016). "Stem cells application ... 16 December 2013 Why Perform a Stem Cell Transplant? Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation ... The FTC also warned a stem cell firm for COVID-19-related marketing. Autologous stem-cell transplantation Cardiovascular Cell ...
... endothelial stem cells (to form lining of blood vessels) from umbilical cord blood; and mesenchymal stem cells (to form ... A proof-of-concept of using induced pluripotent stem cells (iPSCs) to generate human organ for transplantation was reported by ... July 2010). "Reprogramming of human peripheral blood cells to induced pluripotent stem cells". Cell Stem Cell. 7 (1): 20-4. doi ... Embryonic cord-blood cells were induced into pluripotent stem cells using plasmid DNA. Using cell surface endothelial/pericytic ...
Manufacturing of stem cells is done through the collection of cord blood, to then be put in the cord blood bank. Canadian Blood ... After transplantation, donated stem cells that are deemed healthy replace damaged stem cells in a patient's bone marrow and ... Cord blood is the blood remaining in the umbilical cord and placenta after a baby is delivered. Cord blood contains an ... Cord Blood Bank is now officially launched , Canadian Blood Services". www.blood.ca. Retrieved 2019-11-12. "Cord blood matters ...
"Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants)". Retrieved 4 March 2012. CS1 maint: ... Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood- ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ... "Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation". 2005-09-09. Welte, K; Gabrilove, J; Bronchud, MH; ...
"Differentiation of endothelial progenitor cells from human umbilical cord blood CD 34+ cells in vitro". Acta Pharmacologica ... 2 (6). doi:10.1186/2040-2384-2-6. Rafil S, Lyden D (2003). "Therapeutic stem and progenitor cell transplantation for organ ... These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. Progenitor ... red blood cells), megakaryocytes/platelets, mast cells, T-lymphocytes, B-lymphocytes, dendritic cells, natural killer cells, ...
Treatment options may include surgery, radiation therapy, chemotherapy, or stem cell transplantation. Even in cases in which ... mixed types Mixed germ cell and sex cord/gonadal stromal tumors Gonadoblastoma Germ cell-sex cord/gonadal stromal tumor, ... This is because the lymphatic system of the scrotum, through which white blood cells (and, potentially, cancer cells) flow in ... Others Sex cord/Gonadal stromal tumors Leydig cell tumor Sertoli cell tumor Lipid rich variant Scleriosing variant Large cell ...
... unless there is a family member with a current or potential need to undergo a stem cell transplantation. The American Academy ... However, cord blood stem cells (hematopoietic stem cells) are not embryonic stem cells (pluripotent stem cells). Cryo-Cell ... Cord blood stem cells are blood cell progenitors which can form red blood cells, white blood cells, and platelets. This is why ... Since then, cord blood has become increasingly recognized as a source of stem cells that can be used in stem cell therapy. ...
... and stores umbilical cord blood for the purpose of clinical cures and basic research in the field of stem cell transplantation ... LifeSouth Cord Blood Bank participates in the network of public cord blood banks affiliated with the National Marrow Donor ... LifeSouth Cord Blood Bank is a program of LifeSouth Community Blood Centers which performs community and donor education, cord ... LifeSouth Cord Blood Bank is a community-based public cord blood bank that collects ...
Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier. Cell transplantation, 23(4-5 ... normally impermeable blood components like the large molecule albumin or red blood cells can be detected in spinal cord tissue ... which induces BSCB disruption that allows white blood cell migration, followed by the white blood cells releasing more ... It results in increased BSCB permeability that allows white blood cells to migrate into the spinal cord, where they can release ...
... peripheral blood stem cells collected by apheresis, and umbilical cord stem cells. By 2016, this has grown to over 13,000 stem ... On January 13, 2011, City of Hope performed its 10,000th hematopoietic stem cell transplantation, which includes transplants of ... contract to facilitate stem cell research from laboratory to clinical study; focus on development and manufacture of stem cell ... Joy, Darrin S. (2009-12-14). "City of Hope receives $17 million for islet and stem cell informatics". City of Hope - Hope News ...
The T-cells of umbilical cord blood (UCB) have an inherent immunological immaturity, and the use of UCB stem cells in unrelated ... "Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?". Blood. 101 (11): 4233-44. doi:10.1182/ ... GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune ... "Acute GVHD prophylaxis plus ATLG after myeloablative allogeneic haemopoietic peripheral blood stem-cell transplantation from ...
... is used the same way that hematopoietic stem cell transplantation is used to reconstitute bone marrow following ... The stem cells found in cord blood are often confused with embryonic stem cells - unlike embryonic stem cells, cord blood stem ... pluripote "How do embryonic stem cells, somatic stem cells, and cord blood stem cells differ? , NYSTEM". stemcell.ny.gov. ... Cord blood is composed of all the elements found in whole blood - red blood cells, white blood cells, plasma, platelets. ...
... to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to ... "Cord Blood Banking for Potential Future Transplantation". Archived from the original on 2007-10-13. "Cord blood yields 'ethical ... The umbilical cord lining is a good source of mesenchymal and epithelial stem cells. Umbilical cord mesenchymal stem cells (UC- ... 2005). "Anti-inflammatory effects of human cord blood cells in a rat model of stroke". Stem Cells Dev. 14 (5): 595-604. doi: ...
... stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells ... "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ... "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106-12. doi:10.1182/blood ... Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by ...
... or umbilical cord blood. It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. ... Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. The definition of hematopoietic stem ...
Mesenchymal stem cells are found in umbilical cord blood, amniotic fluid, and adipose tissue and can generate a number of cell ... See Hematopoietic stem cell transplantation) Of the types of adult stem cells have successfully been isolated and identified, ... Stem cell Embryonic stem cell Induced pluripotent stem cell Induced stem cells Adult stem cell Cell culture Immortalised cell ... Types of adult stem cells include hematopoietic stem cells and mesenchymal stem cells. Hematopoietic stem cells are found in ...
... including umbilical cord blood.[66] Using genetic reprogramming, pluripotent stem cells equivalent to embryonic stem cells have ... has published a small case series of nine defects in five knees involving surgical transplantation of mesenchymal stem cells ... Hematopoietic stem cells[edit]. Main article: Hematopoietic stem cell. Hematopoietic stem cells (HSCs) are stem cells that can ... Stem cell division and differentiation. A - stem cells; B - progenitor cell; C - differentiated cell; 1 - symmetric stem cell ...
... or umbilical cord blood.[1][2][3] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come ... Cutler C, Antin JH (2001). "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. ... Peripheral blood stem cells[26] are now the most common source of stem cells for HSCT. They are collected from the blood ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ...
"Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics". Exp Cell Res ... Wu DC, Boyd AS, Wood KJ (2007). "Embryonic stem cell transplantation: potential applicability in cell replacement therapy and ... "Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese ... Lindvall O (2003). "Stem cells for cell therapy in Parkinson's disease". Pharmacol Res 47 (4): 279-87. PMID 12644384. ...
"Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell ... The inflammatory cells involved include neutrophil granulocytes and macrophages, two types of white blood cells. Those who ... vocal cords. Laryngopharyngeal reflux (LPR). Vocal fold nodule. Vocal fold paresis. Vocal cord dysfunction. epiglottis. ... Stopping smoking, respiratory rehabilitation, lung transplantation[2]. Medication. Vaccinations, inhaled bronchodilators and ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant?. *↑ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... "A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved ... "Journal of Stem Cells and Regenerative Medicine.. *↑ "Index of CD34+ Cells and Mononuclear Cells in the Bone Marrow of Spinal ... name="nih",Stem Cell Basics: What are the potential uses of human stem cells and the obstacles that must be overcome before ...
Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proceedings of the ... KK Ballen, F Verter and J Kurtzberg Umbilical cord blood donation: public or private? Bone Marrow Transplantation (2015), 1-8 ... Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells ... Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling ...
"Intraspinal stem cell transplantation for amyotrophic lateral sclerosis". Annals of Neurology. 79 (3): 342-53. doi:10.1002/ana. ... low oxygen in the blood) and hypercapnia (too much carbon dioxide in the blood).[14] If their daytime blood gas analysis is ... A few people with ALS have symptoms that are limited to one spinal cord region for at least 12 to 24 months before spreading to ... One 2016 review of stem-cell therapy trials found tentative evidence that intraspinal stem cell implantation was relatively ...
A rare population of hematopoietic progenitor cells enter the thymus from the blood, and expands by cell division to generate a ... derived from bone marrow resident hematopoietic stem cells). Developing T cells are referred to as thymocytes and are of ... but the neck of the flask persists for some time as a cellular cord. By further proliferation of the cells lining the flask, ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ...
Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ... The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, ... Cancer spreading into the Central nervous system (brain or spinal cord) has worse outcomes. ... T cell or pre-B cell Large and heterogeneous (varied) cells ALL - L3 B cell Large and varied cells with vacuoles Mature B-cell ...
Successful photoreceptor transplantation, MIT Technology Review, November 2006. How stem cells might restore sight Technology ... The optic nerve carries the ganglion cell axons to the brain, and the blood vessels that supply the retina. The ganglion cells ... Cone-rod dystrophy (CORD) describes a number of diseases where vision loss is caused by deterioration of the cones and/or rods ... Cells. *Photoreceptor cells (Cone cell, Rod cell) → (Horizontal cell) → Bipolar cell → (Amacrine cell) → Retina ganglion cell ( ...
Hematopoietic stem cell transplantation (HSCT) with high intensity conditioning protocol has been performed in a few cases with ... The presence of antibodies against GAD is the best indication of the condition that can be detected by blood and cerebrospinal ... The antibodies appear to interact with antigens in the brain neurons and the spinal cord synapses, causing a functional ... There is a limited but encouraging therapeutic experience of hematopoietic stem cell transplantation for SPS. ...
Stem cell transplants are a recent research target, because stem cells are easy to manipulate and stem cells transplanted into ... Neural transplantation. Since early in the 1980s, fetal, porcine, carotid or retinal tissues have been used in cell transplants ... Dopamine does not cross the blood-brain barrier, so it cannot be taken as a medicine to boost the brain's depleted levels of ... Spinal cord. *Myelitis: Poliomyelitis. *Demyelinating disease *Transverse myelitis. *Tropical spastic paraparesis. *Epidural ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *↑ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... Index of CD34+ Cells and Mononuclear Cells in the Bone Marrow of Spinal Cord Injury Patients of Different Age Groups: A ... Skin Cells Can Become Embryonic Stem Cells". National Public Radio.. *↑ „Breakthrough Set to Radically Change Stem Cell Debate" ... 2005) "Stem cells: their definition, classification and sources", Stem Cells: From Benchtop to Bedside. World Scientific. ISBN ...
Heart transplantation Organ donation Transplant surgery Brain stem death Non-heart-beating donation Legal death Clinical death ... Instead the spinal cord coordinates the knee-jerk reactions of reflexes including pulling back from the pain of putting a hand ... A beating heart cadaver requires a ventilator to provide oxygen to its blood, but the heart will continue to beat on its own ... The heart contains pacemaker cells that will cause the heart to continue beating even when a patient is brain-dead. Other ...
The living cells that can cause these movements are not living cells from the brain or brain stem, these cells come from the ... Also, a radionuclide cerebral blood flow scan that shows complete absence of intracranial blood flow must be considered with ... Since the 1960s, laws on determining death have, therefore, been implemented in all countries with active organ transplantation ... "Difficulty in brainstem death testing in the presence of high spinal cord injury". British Journal of Anaesthesia. 92 (5): 762 ...
... peripheral blood regulatory T-cells that may account for the significantly different responses after cord blood transplantation ... The PCRF currently awards grants in the following categories of research: Stem cell transplantation Stem cell biology Molecular ... Blood Institute for the establishment of an Umbilical Cord Blood Bank and Umbilical Cord Blood Transplant Center. In 1997, the ... Through the next couple years, the PCRF began to launch research in the areas of immunotherapy and stem cell biology. In 1994, ...
... from adult stem cells or progenitor cells would contribute to overcoming the shortage of donor organs for transplantation. The ... Hormones produced in the pancreatic islets are secreted directly into the blood flow by (at least) five types of cells. In rat ... activates beta cells and inhibits alpha cells. *Glycogen/Glucagon: activates alpha cells which activates beta cells and delta ... PP cells (gamma cells or F cells) producing pancreatic polypeptide (,5%). It has been recognized that the cytoarchitecture of ...
"Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells". Proc. Natl. Acad. Sci ... and hyaluronic acid purified from human umbilical cord is 3,140,000 Da;[3] other sources mention average molecular weight of 7 ... and this protein may be responsible mainly for the clearance of HA from lymph and blood plasma, which accounts for perhaps most ... corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment). Other biomedical ...
Cardiovascular system: pumping and channeling blood to and from the body and lungs with heart, blood and blood vessels. ... The transplantation of larger solid organs often requires immunosuppression to prevent organ rejection or graft vs host disease ... In biology, tissue is a cellular organizational level between cells and complete organs. A tissue is an ensemble of similar ... For example, the liver evolved in the stem vertebrates more than 500 million years ago, while the gut and brain are even more ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *^ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and ... and such research involves adult stem cells, amniotic stem cells, and induced pluripotent stem cells. ... Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. ...
Mesenchymal Stem Cells and the Acute Respiratory Distress Syndrome. *v. *t. *e ... Low tidal volumes (Vt) may cause a permitted rise in blood carbon dioxide levels and collapse of alveoli[10] because of their ... fat emboli and reperfusion pulmonary edema after lung transplantation or pulmonary embolectomy. However, the majority of these ... Vocal cord dysfunction. epiglottis. Epiglottitis. trachea. Tracheitis. Laryngotracheal stenosis. Lower RT/lung disease. ( ...
2009). "Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase ... 2006). "Secondary degeneration reduced by inosine after spinal cord injury in rats". Spinal Cord 44 (7): 421-6. PMID 16317421. ... Oztaş B, Kiliç S, Dural E, Ispir T (November 2001). "Influence of antioxidants on the blood-brain barrier permeability during ... February 2008). "B-cell depletion with rituximab in relapsing-remitting multiple sclerosis". N Engl J Med. 358 (7): 676-88. ...
Peripheral Blood Stem Cells (PBSC):[8] It is possible to collect stem cells from the peripheral blood rather than the bone ... "The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation". Bone Marrow Transplantation. ... that operates the Be The Match Registry of volunteer donors and cord blood units. In May 2004, the Gift of Life Marrow Registry ... This mobilizes stem cells to travel from the bone marrow into the circulating blood. The stem cells are collected through a ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *^ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... Stem cells can also be taken from umbilical cord blood just after birth. Of all stem cell types, autologous harvesting involves ... mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, dental pulp stem cell, etc.).[37][38] Muse cells ( ... Stem cell division and differentiation A: stem cell; B: progenitor cell; C: differentiated cell; 1: symmetric stem cell ...
... stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell transplantation. For ... A combination of human G-CSF and cord blood cells has been shown to reduce impairment from chronic traumatic brain injury in ... Stem cell transplantsEdit. G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate ... White blood cells. The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G- ...
Blood *Special cells for transfusion like platelets (Thrombosomes by Cellphire). *Stem cells. It is optimal in high ... However, none of the fertility restoration options from frozen tissue, i.e. cell suspension transplantation, tissue grafting ... Umbilical cord blood in a Cord blood bank. *Tissue samples like tumors and histological cross sections ... Such machines are used for freezing oocytes, skin, blood products, embryos, sperm, stem cells, and general tissue preservation ...
... regeneration of red blood cells via erythropoiesis occurs through the maturation of erythrocytes from hematopoietic stem cells ... "Liver regeneration in recipients and donors after transplantation". Lancet. 339 (8793): 580-1. doi:10.1016/0140-6736(92)90867-3 ... "Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima". BMC Developmental Biology. 9: 3. doi:10.1186 ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...
... in Shenzhen using Beikes proprietary cord blood stem cell transplantation protocol. ... Chinas leading stem cell research and regenerative medicine company, and Medistem, Inc.,reported positive safety data in 114 ... Study demonstrates safety of cord blood stem cell transplantation protocol to treat neurological conditions. *Download PDF Copy ... in Shenzhen using Beikes proprietary cord blood stem cell transplantation protocol.. The peer-reviewed paper is available at ...
Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems ... cells to generate in greater numbers making them more useful in adult transplantation. ... and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. ... Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a ...
Stem Cell Transplantation Program. *About Stem Cell Transplantation*Types of Stem Cell Transplantation*Information for New ... Advocates of stem cell research have sought an alternative to this approach out of the wish for their childs cord blood to be ... Stanford Medicine Division of Stem Cell Transplantation and Regenerative Medicine - In the Department of Pediatrics Site Nav ... The mission of the Binns Program for Cord Blood Research (BPCBR) is simple: to advance research into a wide array of blood and ...
Broxmeyer, H.E. (2010a). Will iPS Cells Enhance Therapeutic Applicability of Cord Blood Cells and Banking?. Cell Stem Cell 6, ... 2009). Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell 5, 353-357. ... 2009). Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 5, 434-441. Abstract Article ... Cord blood hematopoietic stem cell transplantation (May 26, 2010), StemBook, ed. The Stem Cell Research Community, StemBook, ...
Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking ... Tissue Banking and Transplantation Industry: Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking and Drug ... Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking and Drug Development ... Kalorama Information has tackled the question in Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking and Drug ...
... as an alternative source of stem cells to bone marrow for allogeneic-related and unrelated hematopoietic transplantation. To ... date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants (CBT) have been perform … ... Umbilical cord blood (CB) has been rapidly established ... Cord Blood Stem Cell Transplantation / adverse effects * Cord ... Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results Bone Marrow ...
Umbilical Cord Blood Stem Cell Transplantation in Adults With Advanced Blood Disorders or Cancer. The safety and scientific ... The purpose of this study is to examine the immune system response to cord blood stem cell transplantation in adults with ... The purpose of this study is to evaluate the effectiveness of umbilical cord blood stem cell transplantation in adults with ... Umbilical cord blood is an important source of stem cells and can be used to treat blood and immune system disorders and ...
Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases ... Childhood Langerhans Cell Histiocytosis , Leukemia , Sarcoma , Lymphoma , Protocol Specific , ... Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases Brief ... Cord blood transplant: All patients undergo umbilical cord blood transplantation on day 0. - Graft-versus-host disease ...
Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both ... Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with ... Medical Park, Stem Cell Transplant Unit, Antalya, Turkey.. 12. Erasmus MC Cancer Institute, University Medical Centre, ...
Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for ... Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for ... infuse cord blood) Day after cord blood transplant Infuse family member stem cells 7 days after transplant Start G-CSF ... 1 day after the cord blood transplant Infuse family member stem cells 7 days after transplant Start G-CSF ...
Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases. The ... Cord blood transplant: All patients undergo umbilical cord blood transplantation on day 0. ... RATIONALE: Umbilical cord blood transplantation may be able to replace immune cells that were destroyed by chemotherapy or ... Impact of the use of umbilical cord blood as a source of hematopoietic stem cells. *Comparison of the incidence of graft-vs- ...
... of a Refractory Acute Myeloid Leukemia Patient after a Third Hematopoietic Stem Cell Transplantation with Umbilical Cord Blood ... Although hematopoietic stem cell transplantation (HSCT) has been considered to be the only way for potential cure of relapsed ... She was treated with a toxicity reduced conditioning regimen and received direct intrabone cord blood transplantation (CBT) ... using a single unit of 5/6 HLA-matched cord blood as a graft source. Graft-versus-host disease prophylaxis was performed with a ...
... of a Refractory Acute Myeloid Leukemia Patient after a Third Hematopoietic Stem Cell Transplantation with Umbilical Cord Blood ... Although hematopoietic stem cell transplantation (HSCT) has been considered to be the only way for potential cure of relapsed ... F. Frassoni, F. Gualandi, M. Podestà et al., "Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a ... M. J. Laughlin, M. Eapen, P. Rubinstein et al., "Outcomes after transplantation of cord blood or bone marrow from unrelated ...
Peripheral stem cell transplantation or umbilical cord blood transplantation may be able to replace immune cells that were ... peripheral blood stem cell transplantation Procedure: umbilical cord blood transplantation Radiation: radiation therapy Phase 1 ... Combining either umbilical cord blood transplantation or peripheral stem cell transplantation with antiviral therapy may be an ... Antiviral Therapy Plus Either Peripheral Stem Cell or Umbilical Cord Blood Transplantation in Treating Patients Who Are HIV ...
Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and Chronic ... AdultAgedCord Blood Stem Cell TransplantationGraft vs Host DiseaseHumansLeukemia, Lymphocytic, Chronic, B-CellLymphomaMiddle ... TY - JOUR T1 - Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and ... Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and Chronic ...
... conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood ... conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood ... conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood ... conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood ...
The use of cord blood cells as hematopoietic stem cell grafts for patients with blood cancers receiving an allogeneic stem cell ... Epigenetically Reprogrammed Cells Generate Functional Cord Blood Stem Cells for Transplantation. By Jo Cavallo. Posted: 5/13/ ... of functional cord blood stem cells can be generated by epigenetically reprogramming dividing cord blood CD34-positive cells ... cord blood cells as hematopoietic stem cell grafts for patients with hematologic malignancies receiving an allogeneic stem cell ...
Stem Cell Rev 2:155-162, 2006. Weiss. ML. , Troyer. DL. : Stem cells in the umbilical cord. . Stem Cell Rev. 2. :. 155. -. 162 ... Percutaneous transplantation of human umbilical cord blood-derived multipotent stem cells in a canine model of spinal cord ... Successful stem cell therapy using umbilical cord blood-derived multipotent stem cells for Buergers disease and ischemic limb ... Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. . Biol Blood Marrow ...
BACKGROUND: Reduced intensity stem cell cell transplantation (RIST) from unrelated umbilical cord blood (RI-UCBT) is a novel ... Infectious Complications in Patients Undergoing Reduced Intensity Stem Cell Transplantation (RIST) from Unrelated Umbilical ... Department of Hematology, Toranomon Hospital, Tokyo, Japan; Hematopoietic Stem Cell Transplantation Unit, National Cancer ... Cord Blood (RI-UCBT). Session Type: Publication Only Koichiro Yuji, Shigesaburo Miyakoshi, Daisuke Kato, Eiji Kusumi, Masahiro ...
... when transplanted into patients with blood malignancies. Umbilical cord blood (UCB) is a source of blood stem cells and their ... use to treat patients has been embraced worldwide since the first UCB stem cell transplant in 1988. ... These rare cells are lifesaving, and are often the last resort, ... There is an aura that surrounds stem cells and their use. ... Szilvassy S. Measuring stem cells in cord blood: The value of the CFU assay. Parents Guide to Cord Blood Foundation newsletter ...
These results suggest that ALC recovery is an important prognostic indicator for patients treated with cord blood and T cell- ... We retrospectively analyzed 65 consecutive patients treated at our institution with cord blood (n = 37) and haploidentical (n ... 28) transplantation with myeloablative fludarabine, melphalan, and thiotepa conditioning. Patients with lymphocyte recovery at ... Alternative donor stem cell transplantation from cord blood or haploidentical peripheral blood donors is increasingly being ...
There are several people whose stem cells have found to be extirpated or weakened due to some genetic or chronic disease. Such ... Cord Blood Stem Cells. These days, umbilical cord blood has been considered to be an easy and healthy stem cell source. Along ... white blood cells and red blood cells. Different stem cell sources are found today. The primary source pertaining to stem cells ... cord blood is found to be a good stem cell source which could be stored, processed and retrieved. Cord blood can be obtained ...
2) CB-MSC: 80 - 160 ml umbilical cord blood was harvested and processed likewise as above. (3) Stem cell transplantation: Both ... Eighty-two patients underwent the double transplantations of bone mesenchymal stem cell (BMSC) and human umbilical cord blood ... and umbilical cord mesenchymal stem cells (UMSC) in the treatment of progressive muscular dystrophy (PMD). METHODS A total of ... CONCLUSION The double transplantation of BMSC and CB-MSC is convenient, safe and effective in the treatment of progressive ...
Secondly, the use of cord blood reduces the risk of graft vs host disease. Cord Blood Stem Cell banks have been established in ... Dhot PS, Nair V, Swarup D, Sirohi D, Ganguli P. Cord blood stem cell banking and transplantation. Indian Journal of Pediatrics ... Stem cells have the ability to divide for indefinite periods in culture and to give rise to specialized cells. Cord blood as a ... Since then, the advantages of cord blood as a source of hematopietic stem cells for transplantation have become clear. Firstly ...
Animals , Blood Banks , Blood Specimen Collection , Cord Blood Stem Cell Transplantation/methods , Female , Histocompatibility ... Blood Specimen Collection / Cord Blood Stem Cell Transplantation / Animals Language: English Year: 2005 Type: Article ... Blood Specimen Collection / Cord Blood Stem Cell Transplantation / Animals Language: English Year: 2005 Type: Article ... as an alternative source for hematopoietic stem cell transplantation. Since the first related cord blood transplantation (CBT) ...
Athletes Foot Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells ... Stem Cells - Cord Blood. Encyclopedia section of medindia gives general info about Cord Blood ... Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ... Stem Cells - Fundamentals. Encyclopedia section of medindia gives general info about Stem Cells ...
The risks and efficacy of transplanting two varieties of stem cells into mouse cochlea have been evaluated by Japanese ... Stem Cells - Cord Blood Tinnitus Presbycusis Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem ... Stem Cells - Cord Blood. Encyclopedia section of medindia gives general info about Cord Blood ... Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ...
CBT with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation (JSHCT). ... remains a major complication of cord blood transplantation (CBT). Although the presence of pretransplant, donor-specific anti- ... Peripheral blood as a preferable source of stem cells for salvage transplantation in patients with graft failure after cord ... Phase I/II study of stem-cell transplantation using a single cord blood unit expanded ex vivo with nicotinamide. J Clin Oncol. ...
Cell Biology / Peripheral Blood Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation Type of study: Incidence_ ... Unrelated Donor Peripheral Blood Stem Cell Transplantation Combined with Umbilical Cord Mesenchymal Stem Cells in Patients with ... Mesenchymal Stem Cell Transplantation , Neoplasm Recurrence, Local , Peripheral Blood Stem Cell Transplantation , Retrospective ... Unrelated Donor Peripheral Blood Stem Cell Transplantation Combined with Umbilical Cord Me ...
Identification of miRNAs from stem cell derived microparticles in umbilical cord blood *Angeliki Xagorari ... Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood ... Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation. Bone Marrow Transplant ... Elevation of platelet activation markers and chemokines during peripheral blood stem cell harvest with G-CSF. Stem Cells 2004; ...
  • Although hematopoietic stem cell transplantation (HSCT) has been considered to be the only way for potential cure of relapsed acute myeloid leukemia (AML), there has been no report on a third HSCT in patients with multiple relapsed AML. (hindawi.com)
  • A second HSCT was planned with cord blood as the graft source, because disease progression implied a need for an urgent care. (hindawi.com)
  • A third HSCT using cord blood as the graft source was planned in non-CR status after treatment with a hypomethylating agent, azacitidine, [ 1 , 2 ] at the age of 53 again, because the patient had no significant comorbidities. (hindawi.com)
  • 1 Despite the remarkable improvements in medical therapy for hemoglobinopathies, 3 2 hematopoietic stem cell transplantation (HSCT) still remains the only available curative approach. (haematologica.org)
  • Today, hematopoietic stem cell transplantation (HSCT) from bone marrow (BM), stimulated peripheral blood (PB), and umbilical cord blood (UCB) Is estimated as an effective way of curing for more than 80 serious diseases associated with hematopoietic system disorders. (exp-oncology.com.ua)
  • Hematopoietic stem-cell transplantation (HSCT) is an effective mode of therapy in pediatrics for the treatment of both malignant and non-malignant disorders. (elsevier.com)
  • Hematopoietic stem cell transplantation (HSCT) has been used as curative treatment in both children and adults for hematologic malignancies, immunodeficiencies, autoimmune disorders, and other rare indications. (springer.com)
  • In this chapter, we discuss indications for HSCT, conditioning regimens before transplantation, and types of HSCTs. (springer.com)
  • Albany, NY -- ( SBWIRE ) -- 05/11/2017 -- The competitive landscape in the global market for hematopoietic stem cell transplantation (HSCT) is characterized by the rivalry between the leading market players, such as Regen Biopharma Inc., Cryo-Save AG, Pluristem Therapeutics Inc., and CBR Systems Inc., finds a new research study by Transparency Market Research (TMR). (sbwire.com)
  • Get accurate market forecast and analysis on the Global Hematopoietic Stem Cell Transplantation (HSCT) Market. (sbwire.com)
  • Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation ) or blood . (bionity.com)
  • Autologous HSCT involves isolation of haematopoietic stems cells (HSC) from the patient and storage of the harvested cells in a freezer. (bionity.com)
  • The Asia Pacific Hematopoietic Stem Cell Transplantation Hsct market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by the end of 2024 with a CAGR of XX% from 2019 to 2024. (aarkstore.com)
  • This report is an essential reference for who looks for detailed information on Asia Pacific Hematopoietic Stem Cell Transplantation Hsct market. (aarkstore.com)
  • In addition to the data part, the report also provides overview of Hematopoietic Stem Cell Transplantation Hsct market, including classification, application, manufacturing technology, industry chain analysis and latest market dynamics. (aarkstore.com)
  • Thus, our data suggest that naive donor NK cell repertoires are associated with protection against leukemia relapse after allogeneic HSCT. (jimmunol.org)
  • In humans, such dynamic NK cell responses were been documented primarily in the context of acute or latent infection with CMV ( 7 - 9 ), in particular following allogeneic hematopoietic stem cell transplantation (HSCT) ( 10 - 12 ). (jimmunol.org)
  • Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. (rupress.org)
  • Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies. (rupress.org)
  • In this light, an overview of current usage of CB in the field of unrelated hematopoietic blood stem cell transplantation (HSCT) is given. (dovepress.com)
  • The three main sources of hematopoietic stem cells: bone marrow (BM), peripheral blood stem cells (PBSC), and cord blood (CB) are compared as regards their current quantitative usage in HSCT. (dovepress.com)
  • Until now, patients receiving cord blood transplants to fight hematopoietic diseases were immune-suppressed in order to prevent a potentially devastating condition known as 'graft versus host. (news-medical.net)
  • The findings have important implications for patients battling blood cancers and the difference between success and failure of life saving stem cell transplants. (news-medical.net)
  • 1989 ), and subsequent CB transplants (Broxmeyer and Smith, 2009 ) were made possible by the biological laboratory studies that suggested CB as a potential source of transplantable hematopoietic stem (HSC) and progenitor (HPC) cells (Broxmeyer et al. (stembook.org)
  • To date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants (CBT) have been performed, mostly in children, for the treatment of a variety of malignant and nonmalignant conditions. (nih.gov)
  • Stem cell transplants of umbilical cord blood have been shown to be effective in treating illness in children, but more research is needed to confirm the benefit of this procedure in adults. (clinicaltrials.gov)
  • While bone marrow transplants are the most common method for stem cell donations, research has shown that there are many advantages to using allogeneic grafts of stem cells obtained from umbilical cord blood. (clinicaltrials.gov)
  • Compare the incidence of graft-versus-host disease in patients receiving cord blood transplants in this study with historical data for unrelated donor stem cell transplants. (centerwatch.com)
  • OBJECTIVES: I. Determine the feasibility and safety of combination antiretroviral therapy followed by HLA matched sibling peripheral blood stem cell or unrelated umbilical cord blood transplants in HIV infected adults with hematologic malignancies. (clinicaltrials.gov)
  • Patients who are given umbilical cord blood (UCB) transplants undergo collection of autologous peripheral blood stem cells (PBSC) prior to the myeloablative conditioning regimen in case there is UCB graft failure. (clinicaltrials.gov)
  • Limited studies have reported on outcomes for lymphoid malignancy patients receiving alternative donor allogeneic stem cell transplants. (unboundmedicine.com)
  • Three of 4 dogs (Groups 4 and 5) that received cellular transplants exhibited gradual improvement in hindlimb locomotion from 3 weeks after cell transplantation. (thejns.org)
  • Since the first cord blood transplant in 1988, over 2500 cord blood HSC transplants have been done world wide. (who.int)
  • Currently, more than 65,000 units are available and more than 2500 patients have received transplants of cord blood. (who.int)
  • Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. (nature.com)
  • The literature shows there is a wide experience in transplantation for TM, whereas only a few hundred transplants have been performed for SCD. (haematologica.org)
  • A clinical trial at MSK has shown that fecal transplants are safe in people who have had stem cell or bone marrow transplants. (mskcc.org)
  • According to The Worldwide Network of Blood and Marrow Transplantation (WBMT), the dominance of allogeneic variants over autologous transplants is the current trend of the global growth [4]. (exp-oncology.com.ua)
  • CD34+ cord blood cells increase faster than adult bone marrow cells in culture, allowing a 10-fold lower CD34+ cell dose to be used in cord blood transplants [3, 5]. (springer.com)
  • Chow R, Nademanee A, Rosenthal J, Karanes C, Jaing TH, Graham ML (2007) Analysis of hematopoietic cell transplants using plasma-depleted cord blood products that are not red blood cell reduced. (springer.com)
  • Recipients of stem cell transplants may be severely immunocompromised for many months after transplantation, especially if they are still taking immunosuppressive drugs. (cmaj.ca)
  • Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and recipient matching for major histocompatibility (HLA) antigens. (cmaj.ca)
  • Works Cited Bone Marrow and Stem Cell Transplants for Chronic Myeloid Leukaemia (CML). (123helpme.com)
  • 6 In addition to these treatments, bone marrow transplants have been shown to supply stem cells that regenerate cells in the liver. (icr.org)
  • Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? (frontiersin.org)
  • As cord blood (CB) enables rapid access and tolerance to HLA mismatches, a number of unrelated CB transplants have reached 30,000. (frontiersin.org)
  • This review will focus on biological features of CB and comparison of transplants with CB vs. adult stem cells. (frontiersin.org)
  • Although CBUs belong to 2.5% of the stem cell pool, thanks to introduction of dCB transplants (dCBT) that contribute to approximately 20% of the unrelated stem cell transplants ( 1 , 2 ). (frontiersin.org)
  • Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's Sarcoma , Desmoplastic small round cell tumor , Hodgkin's disease , and multiple myeloma . (bionity.com)
  • Allogeneic transplants are also performed using umbilical cord blood as the source of stem cells. (bionity.com)
  • The team is actively involved in clinical research in bone marrow and peripheral blood stem cells transplants. (karmanos.org)
  • Our partnership with the Children's Hospital of Michigan at the Detroit Medical Center makes Karmanos an accredited center not only for the treatment of adults, but children of all ages who need bone marrow or stem cell transplants. (karmanos.org)
  • Read our guide to autologous stem cell transplants . (mskcc.org)
  • It is easier than taking cells from a person's bone marrow, which is sometimes done for allogeneic transplants. (mskcc.org)
  • LifebankUSA has released cord blood stem cell units for sibling transplants, resulting in 100% survival rates in treating both hemoglobinopathies and malignant diseases. (lifebankusa.com)
  • With over 6,000 transplants since 1990 and some 400 every year, we have one of the largest and most experienced transplantation programs in the United States. (hackensackumc.org)
  • Allogeneic stem cell transplants for patients who are older or have overall poor health are relatively uncommon. (lls.org)
  • However, reduced intensity allogeneic stem cell transplants may be an appropriate treatment for some older or sicker patients. (lls.org)
  • 17 Although the number of patients who receive unrelated adult allogeneic donor stem cell transplants continues to increase each year, many patients are unable to find a fully matched donor, which diminishes access to transplantation therapy. (aappublications.org)
  • BMT InfoNet is dedicated to providing transplant patients, survivors and their loved ones with emotional support and high quality, easy-to-understand information about bone marrow, peripheral blood stem cell and cord blood transplants. (lls.org)
  • The fact that Beike has been able to demonstrate safety of transplant by manipulating an established stem cell source is a substantial advancement for the field. (news-medical.net)
  • Upon receiving an allogeneic stem cell transplant using umbilical cord blood, participants will be observed for successful engraftment in which the transplanted stem cells 'take' and begin producing new blood cells. (clinicaltrials.gov)
  • Participants will receive an allogeneic umbilical cord blood stem cell transplant and will be closely monitored while in the hospital to determine when engraftment occurs and if GVHD develops. (clinicaltrials.gov)
  • OBJECTIVES: Primary - Determine the impact of the use of umbilical cord blood as a source of hematopoietic stem cells for children with life-threatening oncologic, hematologic, or genetic/metabolic disorders in need of a stem cell transplant. (centerwatch.com)
  • Cord blood transplant: All patients undergo umbilical cord blood transplantation on day 0. (centerwatch.com)
  • The purpose of this study is to find out whether the addition of blood stem cells from a close family member, when added to umbilical cord blood will make the transplant safer. (clinicaltrials.gov)
  • Patients underwent transplant for Hodgkin lymphoma (n = 9, 21%), CLL (n = 5, 12%) and non-Hodgkin lymphomas (n = 28, 67%), including 13 T cell lymphomas. (unboundmedicine.com)
  • Six (14%) and 1 (2%) patients had prior autologous and allogeneic stem cell transplant, respectively. (unboundmedicine.com)
  • In conclusion, haplo-cord transplantation offers a transplant alternative for patients with recurrent or refractory lymphoid malignancies who lack matching donors. (unboundmedicine.com)
  • Chakraverty et al, Blood 99:1071-1078, 2002), there is little data regarding the use of a RI AlloSCT approach for children and adolescents with malignant diseases (Gomez et al, Biol Blood Marrow Transplant 9:157-161, 2003). (aacrjournals.org)
  • We determined the degree of engraftment and mixed-donor chimerism following RI AlloSCT in children with malignant diseases following matched-family donor (MFD) and umbilical cord blood transplant (UCBT). (aacrjournals.org)
  • The use of cord blood cells as hematopoietic stem cell grafts for patients with blood cancers receiving an allogeneic stem cell transplant has been limited to children due to the small number of stem cells present in a single cord blood collection. (ascopost.com)
  • Umbilical cord blood (UCB) is a source of blood stem cells and their use to treat patients has been embraced worldwide since the first UCB stem cell transplant in 1988 [1]. (parentsguidecordblood.org)
  • Yet, despite this success, most people would be surprised to learn that when a UCB stem cell transplant is performed, neither the quality (the ability of the cells to proliferate) nor potency (a quantitative measure of biological function) of the stem cells are determined before they are given to the patient - in fact, the stem cell content is not measured at all [2]. (parentsguidecordblood.org)
  • Early lymphocyte recovery predicts superior outcomes after unmanipulated haploidentical blood and marrow transplant for acute myeloid leukemia. (semanticscholar.org)
  • What is Stem Cell Transplant All About? (nachoserapio.com)
  • However, a compatible and eligible donor will be required to carry out bone marrow or peripheral blood transplant. (nachoserapio.com)
  • Although stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy for malignancy, it involves some serious transplant-related complications. (nature.com)
  • 3 Overview: UCB Transplant Allogeneic transplantation for hematology patients is limited by graft availability. (docplayer.net)
  • However, only a few controlled trials have been reported, and decisions on patient selection for hematopoietic stem cell transplantation and transplant management remain principally dependent on data from retrospective analyses and on the clinical experience of the transplant centers. (haematologica.org)
  • This consensus document from the European Blood and Marrow Transplantation Inborn Error Working Party and the Paediatric Diseases Working Party aims to report new data and provide consensus-based recommendations on indications for hematopoietic stem cell transplantation and transplant management. (haematologica.org)
  • Juliet Barker, Director of Memorial Sloan Kettering's Cord Blood Transplant Program, discusses MSK's expertise in cord blood transplantation. (mskcc.org)
  • It was found that UCB transplantation in adults is a viable method when a matched bone marrow transplant cannot be identified. (wpi.edu)
  • In addition, the availability of an infrastructure in the form of a national hematopoietic stem cell (HSC) registries with a wide list of donors, large cord blood banks (CBBs), and transplant centers with professional cohesive teams is very important. (exp-oncology.com.ua)
  • Sufficient progenitor cells were also found in the human cord blood, and was used to promote engraftment, leading to the first successful cord blood transplant in 1988 [2, 4]. (springer.com)
  • 12 It is the care of the patient after transplantation that can present much more of a challenge to the multidisciplinary care team, especially in the setting of allogeneic transplant. (cmaj.ca)
  • In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
  • We studied the clinical outcomes of 171 adults with hematologic malignancies who received unrelated cord blood transplantation (CBT) as a primary unrelated stem-cell source (n = 100), or bone marrow transplant (BMT) or peripheral blood stem-cell transplant (PBSCT) from related donors (n = 71, 55 BMT and 16 PBSCT). (elsevier.com)
  • Nonmelanoma skin cancer in childhood after hematopoietic stem cell transplant: a report of 4 cases. (springer.com)
  • WebsiteCommentsLinkTagsParentheticalEditDelete 'Hematopoietic Progenitor Cell Transplant. (123helpme.com)
  • Such transplant activity has been the result of international accreditation programs maintaining highly qualified cord blood units (CBUs) reaching more than 600,000 CBUs stored worldwide. (frontiersin.org)
  • If you're in need of a bone marrow or stem cell transplant, it's important to be evaluated by the experts in this field before beginning treatment. (karmanos.org)
  • Karmanos' Bone Marrow & Stem Cell Transplant Multidisciplinary Team includes specialists in medical hematology and oncology, infectious disease, immunotherapy, pediatrics and internal medicine who bring years of experience to the field of transplantation. (karmanos.org)
  • This survival data is reported yearly from the Center for International Blood and Marrow Transplant Registry for all 168 transplant centers in the U.S. The data are adjusted for several risk factors that may have a major influence on outcome. (karmanos.org)
  • Thousands of cord blood units are donated daily to public cord blood banks for use in life-saving transplant procedures across the country. (stanford.edu)
  • Following the stem cell transplant, the median time to syndrome onset was 131 days, although in one patient onset was more than 300 days later. (medpagetoday.com)
  • A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
  • In an autologous transplant, your own blood-forming stem cells are collected. (mskcc.org)
  • Once your stem cells have been collected and you know the date of the transplant, you will go through a process called a preparative regimen. (mskcc.org)
  • Between two and three weeks after the transplant, doctors usually start to find newly formed blood cells in the patient's bloodstream. (mskcc.org)
  • With time, a successful transplant graft will make red blood cells, white blood cells, and platelets. (mskcc.org)
  • Biology of Blood and Marrow Transplant. (ucdenver.edu)
  • Biology of Blood and Marrow Transplant 2013;19:393-397. (ucdenver.edu)
  • 9. Milano F, Chien JW, Riffkin I, Gutman JA, Newell L, Pergam SA, Delaney C. Stable long-term pulmonary function after myeloablative double cord blood transplant. (ucdenver.edu)
  • Biology of Blood and Marrow Transplant 2012;18:309-13.Milano F, Pergam SA, Xie H, Leisenring WM, Gutman JA, Riffkin I, Chow V, Boeckh MJ, Delaney C. Intensive strategy to prevent cytomegalovirus disease in seropositive umbilical cord blood transplant recipients. (ucdenver.edu)
  • Autologous stem cell transplant is considered investigational and not medically necessary for individuals with ALL. (unicare.com)
  • Other cord blood banks use an automated process delivering lower purity levels,8,9 which can lead to transplant complications. (lifebankusa.com)
  • LifebankUSA's red blood cell removal process eliminates the need for additional manipulation and preparation of your baby's stem cells, should a transplant ever be needed. (lifebankusa.com)
  • Once processing is complete, our lab specialists transfer your stem cells to a transplant cartridge for preservation, where they are cryopreserved in a vapor-phase liquid nitrogen storage tank at approximately -190°C. The temperature is monitored 24 hours a day, 7 days a week. (lifebankusa.com)
  • Our processing procedures are tested and validated, giving you confidence that your cord blood banking collection is well preserved and transplant-ready. (lifebankusa.com)
  • Learn more about our Blood and Marrow Transplant Program at Children's National. (childrensnational.org)
  • If the transplant is successful, new bone marrow cells will produce healthy red blood cells, white blood cells, and platelets. (lahey.org)
  • In order for the transplant to be successful, certain markers on the blood cells and bone marrow cells must match. (lahey.org)
  • Together, these results have important implications for improving hematopoietic stem/progenitor cell transplant not only for patients with WHIM but also for all patients who may require the procedure. (jci.org)
  • Your transplant team features doctors with decades of experience in stem cell and bone marrow transplantation, including specialists who focus on specific diseases such as leukemia and multiple myeloma. (hackensackumc.org)
  • We also have one of the largest apheresis facilities in the country (performing removal of stem cells for harvesting and transplantation), and one of the strongest photophoresis programs-a therapy to treat complications after transplant, such as graft-versus-host disease (a complication in which immune cells from the donor attack tissues of the recipient, causing inflammation and other symptoms). (hackensackumc.org)
  • The immune reaction, or GVHD, is treated by administering drugs to the patient after the transplant that reduce the ability of the donated immune cells to attack and injure the patient's tissues. (lls.org)
  • One goal of allogeneic stem cell transplant is to cause the T lymphocytes in the donor's blood or marrow to take hold (engraft) and grow in the patient's marrow. (lls.org)
  • The technique involves treating the stem cells collected for transplant with agents that reduce the number of T lymphocytes. (lls.org)
  • If the HLA on the donor cells are identical (from identical twins, for example) or similar (such as those from siblings), the transplant is more likely to be successful. (lls.org)
  • A savior baby or savior sibling is a child who is conceived in order to provide an organ or cell transplant to a sibling that is affected with a fatal disease, such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem cell transplantation. (wikipedia.org)
  • Disadvantages of CB, compared to BM and MPB, include the low, and sometimes limiting, number of cells collected in single donor units which can be less than optimal for engraftment of many adults and higher weight children, and the relatively slower speed to engraftment of neutrophils and platelets. (stembook.org)
  • While limiting numbers of nucleated cells found in single units of CB can be compensated for by transplantation of more than 1 unit of CB, this use of multiple cord blood units may be associated with increased GVHD, and has not meaningfully reduced the time to neutrophil and platelet engraftment. (stembook.org)
  • We have previously described combining CD34-selected haploidentical grafts with umbilical cord blood (haplo-cord) to accelerate neutrophil and platelet engraftment. (unboundmedicine.com)
  • Thus, haplo-cord achieves high rates of engraftment and encouraging results. (unboundmedicine.com)
  • This reliance on TNC will be important later, because the miscellaneous cells that contribute to the TNC act to dilute and mask the rare stem cells responsible for engraftment. (parentsguidecordblood.org)
  • Haploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability. (semanticscholar.org)
  • Impact of total body irradiation on successful neutrophil engraftment in unrelated bone marrow or cord blood transplantation. (nature.com)
  • 7 The use of blood stem cells is associated with faster recovery of neutrophils and platelets after transplantation (engraftment) than is the case with bone marrow stem cells. (cmaj.ca)
  • This section describes the 4 components of allogeneic transplantation - conditioning, transplantation, engraftment and immunoreconstitution ( Fig. 2 ) - and provides information about the patient's hospital stay and the risks associated with this type of transplantation. (cmaj.ca)
  • We retrospectively examined the conditioning regimens, stem cell source and dose, days to engraftment, survival and complication rate to see whether there was a significant advantage in using one source over the other. (elsevier.com)
  • Dipeptidyl peptidase-4 (DPP4) inhibition is a potential strategy to increase the engraftment rate of haematopoietic stem/progenitor cells. (nih.gov)
  • How to Improve Cord Blood Transplantation: By Enhancing Cell Counts or Engraftment? (frontiersin.org)
  • Efforts to increase stem cell content or engraftment rate of the graft by ex vivo expansion, modulation by molecules such as fucose, prostaglandin E2 derivative, complement CD26 inhibitors, or CXCR4/CXCL12 axis have been able to accelerate engraftment speed and rate. (frontiersin.org)
  • Fludarabine pharmacokinetics will be measured and correlated with the kinetics of donor cell engraftment as well frequency of treatment-related toxicity. (knowcancer.com)
  • CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells. (waterstones.com)
  • More research is needed to understand cell-autonomous and non-cell-autonomous regulation of HSC induction, homing, and engraftment. (rupress.org)
  • The sites of blood development and the molecular signals regulating hematopoiesis are conserved with mammalian systems, and zebrafish embryos are transparent, allowing for noninvasive visualization of HSC emergence, migration, and engraftment. (rupress.org)
  • Umbilical cord blood (CB) is a clinically useful source of hematopoietic stem (HSC) and progenitor (HPC) cells for treatment of a wide variety of malignant and non-malignant disorders. (stembook.org)
  • Non-HSC/HPC include mesenchymal stem/stromal cells (MSC), endothelial progenitor cells (EPC), and induced pluripotent stem cells (iPSC). (stembook.org)
  • Caution is clearly required for non HSC/HPC stem/progenitor cell uses of CB, based on insufficient biological and preclinical information for MSC, EPC, and iPSC. (stembook.org)
  • and the Colony-Forming Unit (CFU) assay which tests the in vitro growth of progenitor cells [6,7]. (parentsguidecordblood.org)
  • A 100 ml unit of cord blood contains 1/10th the number of nucleated cells and progenitor cells (CD34+ cells) present in 1000 ml of bone marrow, but because they proliferate rapidly, the stem cell in a single unit of cord blood can reconstitute the entire haematopoietic system. (who.int)
  • Long-term follow-up of patients who experienced graft failure postallogeneic progenitor cell transplantation. (nature.com)
  • The initial observations on the potential of umbilical cord blood came from the laboratories of Broxmeyer, Knudtzon, Lansford, Metcalf and others, demonstrating that the cord blood contained a high percentage of granulocyte-macrophage progenitor cells [1-3]. (springer.com)
  • These initial experiments led to work in a murine model, showing that neonatal mice contain sufficient progenitor cells that repopulate the lethally irradiated mice. (springer.com)
  • Cairo MS, Wagner EL, Fraser J et al (2005) Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: A cord blood transplantation (COBLT) study report. (springer.com)
  • Hematopoietic Progenitor Cell Transplantation: Not. (123helpme.com)
  • understanding what guides the differentation of progenitor cells into corticospinal neurons and interneurons in the human fetal brain. (ncl.ac.uk)
  • CB progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating capacity compared to bone marrow-mesenchymal stromal cells and lesser oncogenic potential than progenitor-induced stem cells. (frontiersin.org)
  • Stem or progenitor cells are defined by their capacity to undergo cell renewal and asymmetric cell division, which leads to their differentiation and formation of one or more mature tissues and preservation of the stem cell population [ 3 ]. (lww.com)
  • For umbilical cord transplantation, see TRANS.00016 Umbilical Cord Blood Progenitor Cell Collection, Storage and Transplantation for additional information and criteria. (unicare.com)
  • Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. (waterstones.com)
  • It is a source of hematopoietic progenitor and stem cells, and enables investigation in genetics, immunology, etc. (waterstones.com)
  • In recent years, umbilical cord blood, which contains a rich source of hematopoietic stem and progenitor cells, has been used successfully as an alternative allogeneic donor source to treat a variety of pediatric genetic, hematologic, immunologic, and oncologic disorders. (aappublications.org)
  • 1 - 16 Allogeneic (related or unrelated) or autologous (self) bone marrow or peripheral blood stem cells are the usual sources of hematopoietic progenitor cells to achieve this goal. (aappublications.org)
  • The study, published in the May issue of The Journal of Clinical Investigation , looked at ways to expand the number of hematopoietic stem cells (HSC) in the laboratory required to replenish and renew blood cells. (news-medical.net)
  • As the visionaries behind Stanford's novel cord blood donation program, the Binns family shares our objective for advancing clinical science and current treatment approaches to various blood and immune disorders through cord blood research. (stanford.edu)
  • This information could provide the means to modulate these cells for greater clinical advantage. (stembook.org)
  • There is also the potential, as yet far from proven in a clinical sense for use of mature cells generated from HSC/HPC, and for non-HSC/HPC uses of CB. (stembook.org)
  • In turn, these findings may guide future umbilical cord blood stem cell clinical trials. (clinicaltrials.gov)
  • The findings may provide clinical benefit for adults with leukemia, lymphoma, and other blood cancers. (ascopost.com)
  • Clinical use of cord blood for stem cell transplantation. (bvsalud.org)
  • Autologous (self-donated) muscle-derived stem cells have demonstrated therapeutic potential for SUI in animal models and in clinical trials. (medindia.net)
  • The clinical data of 49 patients received unrelated donor peripheral blood stem cells transplantation (URD-PBSCT) for treating hematologic malignancies were retrospectively evaluated, including 12 ANLL, 17 ALL, 18 CML and 2 MDS. (bvsalud.org)
  • In the last years, the widely consolidated clinical experience in the field of hematology has encouraged the use of bone marrow (BM)- and cord blood (CB)-derived stem cells in nonhaematological disease. (nystemcelltherapy.com)
  • In the field of diabetes, a huge amount of clinical trials for the cure of type 1 and type 2 diabetes, involving BM-derived HSC and both BM- and CB-derived MSC got underway, thanks also to the availability of simple protocols for collection, culture and storage of these stem cells. (nystemcelltherapy.com)
  • This review recapitulates the historical use of BM- and CB-derived stem cells in diabetes therapy, alone or in combination with islet transplantation, and focuses on the most relevant information on preclinical experimental data and provides an update on the most recent clinical trials. (nystemcelltherapy.com)
  • The purpose of this project is to analyze clinical studies comparing HSCs from a single cord blood unit (CBU) to HSCs from bone marrow, and to explore methods of increasing limited amounts of HSCs. (wpi.edu)
  • Further investigation, subsequent to the initial clinical studies, revealed the unique properties of umbilical cord blood grafts. (springer.com)
  • Broxmeyer HE, Kurtzberg J, Gluckman E et al (1991) Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. (springer.com)
  • No prospective randomized clinical trial will be able to provide a definitive answer to the challenge of choosing between HSC transplantation and medical therapy for each individual patient. (haematologica.org)
  • From a scientific perspective adult stem cells have several clinical advantages over embryonic stem cells. (icr.org)
  • Adult stem cells are maintained throughout the body, they are currently used in many clinical applications, and if a patient uses his own adult stem cells, an immune response causing tissue rejection is avoided. (icr.org)
  • Adult stem cells from these niches are currently being used to treat a number of diseases and more applications are in clinical trials. (icr.org)
  • 8 Clinical trials with neural stem cells to treat a neurodegenerative disease, amyotrophic lateral sclerosis (ALS), 9 and bone marrow stem cells to replace damaged heart tissue from the effects of myocardial ischaemia (decreased blood flow to the heart associated with heart attack) 10 have also demonstrated the potential of adult stem cell treatments. (icr.org)
  • A recent clinical trial using sitagliptin, a DPP4 inhibitor approved for type 2 diabetes mellitus, has been shown to be a promising approach in adults with haematological malignancies after umbilical cord blood (UCB) haematopoietic cell transplantation (HCT). (nih.gov)
  • In addition, its recent use in several regenerative medicine clinical trials has further spurred the motivation to collect and bank these stem cells. (elsevier.com)
  • Harris, DT 2008, ' Collection, processing, and banking of umbilical cord blood stem cells for clinical use in transplantation and regenerative medicine ', Laboratory Medicine , vol. 39, no. 3, pp. 173-178. (elsevier.com)
  • Bone marrow-derived mesenchymal stem cells (MSCs) have been reported to prevent the development of liver fibrosis in a number of pre-clinical studies. (scienceopen.com)
  • In more recent times, there has been a growing need for cord blood within the research community - a need that has yet to be sufficiently addressed, as only those cord blood units that are deemed inadequate for clinical use are redirected toward research purposes, if not discarded. (stanford.edu)
  • He serves as the director of allogeneic stem cell transplantation, co-medical director of the University of Colorado Cord Blood Bank, laboratory medical director of the clinical stem cell laboratory, and chairman of the University of Colorado Cancer Center Protocol Review and Monitoring system. (ucdenver.edu)
  • I am a clinical/translational researcher focused on blood cancers and stem cell transplantation. (ucdenver.edu)
  • The editors and authors of this book not only address current clinical science and banking of umbilical-cord blood, but also advance new concepts in medical therapeutics that use umbilical-cord blood. (waterstones.com)
  • Presenting new technologies, specific case studies, updates on GMP, MHRA regulatory guidelines, quality control and therapeutic applications of stem cells, pre-clinical and clinical trial design, advanced cell engineering technologies, commercialisation of ATMPs, global pricing, ethical overviews and many more. (smi-online.co.uk)
  • Pamela has advised and supported successful applications for cell and gene therapy projects which she is now managing in both the pre-clinical and early clinical phases. (smi-online.co.uk)
  • Hierarchical clustering of high-resolution immunophenotyping data covering key NK cell parameters, including frequencies of CD56 bright , NKG2A + , NKG2C + , and CD57 + NK cell subsets, as well as the size of the educated NK cell subset, was linked to clinical outcomes. (jimmunol.org)
  • Stem cell selection is another technique being studied in clinical trials that can reduce the number of T lymphocytes that a patient receives. (lls.org)
  • 19 - 23 With advances in the clinical practice of cord blood transplantation, most patients unable to find a fully matched adult donor can identify a partially matched cord blood donor. (aappublications.org)
  • To advance the clinical application of newborn stem cells by partnering with leading research institutions to establish FDA-regulated clinical trials, exclusive to CBR families, for conditions that have no cure today. (lls.org)
  • 1 Hematology/Oncology Department and Bone Marrow Transplantation Unit, Niño Jesus Children's Hospital, Autonomous University, Madrid, Spain. (nih.gov)
  • Stem cell transplantation is a medical procedure in the fields of hematology and oncology , most often performed for people with diseases of the blood , bone marrow , or certain types of cancer . (bionity.com)
  • Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both strategies that have shown encouraging results in patients who do not have an human leukocyte antigen (HLA)-matched sibling or unrelated donor. (nih.gov)
  • Reduced intensity conditioning and allogeneic stem cell transplantation in children and adolescents with malignancies from unrelated cord blood and matched family donors results in 92% achieving ≥95% donor chimerism. (aacrjournals.org)
  • Donors included: 8 unrelated UCB (seven 4/6, one 5/6), 1 related UCB (6/6), and 4 related peripheral blood stem cells (PBSC) (two 6/6, two 5/6). (aacrjournals.org)
  • Alternative donor stem cell transplantation from cord blood or haploidentical peripheral blood donors is increasingly being used for patients who lack a matched related or unrelated donor. (semanticscholar.org)
  • Cord Blood Stem Cell banks have been established in Europe and United States to supply HSC for related and unrelated donors. (who.int)
  • Since the first related cord blood transplantation (CBT) was performed successfully for a child with Fanconi Anemia in 1988, there have been many children undergoing CBT from related donors . (bvsalud.org)
  • Peripheral-blood stem cells versus bone marrow from unrelated donors. (nature.com)
  • Cord blood banking has been the focus of many medical centers as it can provide a virtually unlimited source of ethnically-diverse stem-cell donors. (elsevier.com)
  • In both models, hematopoietic reconstitution was markedly superior using BM cells from donors hemizygous for Cxcr4 (Cxcr4+/o) compared with BM cells from Cxcr4+/+ donors. (jci.org)
  • Because there is diminished risk of graft-versus-host disease after transplantation of cord stem cells using matched related donors, the use of less-than-completely matched HLA cord blood stem cells may incur less risk of graft-versus-host disease than mismatched cells from either a related or unrelated "walking" donor, although this remains to be proven. (aappublications.org)
  • This is a 2 arm phase 2 study to obtain an estimate of the speed of neutrophil recovery after myeloablative CBT with abrogation of prolonged cytopenia by infusion of haploidentical family member T-cell depleted PBSC in patients with high-risk or advanced hematologic malignancies. (clinicaltrials.gov)
  • Here, we examine the outcome of patients with lymphoid malignancies undergoing haplo-cord transplantation at the University of Chicago and Weill Cornell Medical College. (unboundmedicine.com)
  • These rare cells are lifesaving, and are often the last resort, when transplanted into patients with blood malignancies. (parentsguidecordblood.org)
  • Allogeneic bone marrow transplantations (BMT) from HLA-matched siblings have been successfully used for treatment of patients with high- risk hematological malignancies , genetic immunodeficiencies, metabolic disorders, or marrow failure syndromes . (bvsalud.org)
  • The issue of HSC transplantation in genetic disease is much different from that of HSC transplantation in malignancies. (haematologica.org)
  • 6. Ostronoff F, Milano F, Gooley T, Gutman JA, McSweeney P, Petersen F, Sandmaier BM, Storb R, Delaney C. Umbilical cord blood transplantation in patients with hematological malignancies using a non-ATG containing reduced intensity preparative regimen. (ucdenver.edu)
  • There are few choices available for the people today such as the embryonic stem cells, bone marrow stem cells, peripheral blood cell and the most new is the umbilical cord blood. (123helpme.com)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy in the form of total body irradiation to eradicate the patient's malignant cell population at the cost of also eliminating the patient's bone marrow stem cells, then return of the patient's own stored stem cells to their body. (bionity.com)
  • Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. (news-medical.net)
  • The mission of the Binns Program for Cord Blood Research (BPCBR) is simple: to advance research into a wide array of blood and immune disorders, from leukemia to sickle cell disease, by providing Stanford researchers with umbilical cord blood, an invaluable yet often over-looked resource. (stanford.edu)
  • Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT. (nih.gov)
  • We analyzed 42 lymphoma and chronic lymphoblastic leukemia (CLL) patients who underwent haplo-cord allogeneic stem cell transplantation. (unboundmedicine.com)
  • Nowadays, multiple diseases such as Lymphomas and Leukemia are being treated using cord blood stem cells. (nachoserapio.com)
  • Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. (nature.com)
  • INTRODUCTION: -cancer is a terminal disease that is effecting the population today - Leukemia is one type of cancer that currently effects 310, 046 people with an added estimated 48,610 expected to be diagnosed - Leukaemia is a cancer of the blood and bone marrow. (123helpme.com)
  • Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
  • Adult stem cells from bone marrow are used to treat more than 70 diseases including leukemia and breast cancer. (icr.org)
  • The leukemia segment, on the other hand, is projected to lose a little in the years to come due to the advent of new, improved, and cost efficient drugs that may decrease demand for expensive hematopoietic stem cell transplantation. (sbwire.com)
  • This study will explore the feasibility, safety and efficacy of allogeneic stem cell transplantation from unrelated, cord-blood and haploidentical donor in patients with an active leukemia. (knowcancer.com)
  • In this first report of autologous cord blood transplantation for treatment of childhood leukemia, we discuss the safety and feasibility of this procedure as well as some of the uncertainties surrounding autologous cord blood collection and usage. (bioeticaweb.com)
  • In addition to the rare availability of autologous cord blood, there is a concern that it may contain the leukemic clone that progressed to cause the child's leukemia. (bioeticaweb.com)
  • A cerebrospinal fluid cell count and cytological examination were normal, with no evidence of leukemia. (bioeticaweb.com)
  • The patient was treated with a high-risk leukemia protocol because of the presence of a very high white cell count. (bioeticaweb.com)
  • To facilitate transplantation of volunteer unrelated donor stem cells as curative therapy for patients around the world of all socioeconomic backgrounds, suffering from leukemia and a wide-range of life-threatening diseases. (lls.org)
  • Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome. (harvard.edu)
  • Prior to PBSC or UCB transplantation on day 0, all patients receive a myeloablative conditioning regimen. (clinicaltrials.gov)
  • To explore the safety and efficiency of unrelated donor peripheral blood stem cells (URD-PBSC) transplantation combined with umbilical cord mesenchymal stem cells (UC-MSC). (bvsalud.org)
  • The transplantation of URD-PBSC combined with UC-MSC is effective and safe. (bvsalud.org)
  • PBSC harvesting is similar to giving blood. (mskcc.org)
  • The authors noted that embryonic stem cells have previously been identified as promising candidates for transplantation, however they have also been associated with immune rejection and ethics issues. (medindia.net)
  • Adult stem cells can be collected from a donor or even from the individual needing treatment, whereas the collection of embryonic stem cells requires destruction of the embryo (presumably a human individual). (icr.org)
  • Recent progress in research involving adult stem cells may make the use of the ethically challenged embryonic stem cells irrelevant. (icr.org)
  • Thus, CB has many features resembling fetal or even embryonic stem cells. (frontiersin.org)
  • Which is more important for the selection of cord blood units for haematopoietic cell transplantation: the number of CD34-positive cells or total nucleated cells? (nature.com)
  • Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leu. (nih.gov)
  • Lymphocyte recovery predicts outcomes in cord blood and T cell-depleted haploidentical stem cell transplantation. (semanticscholar.org)
  • High risk of graft failure in patients with anti-HLA antibodies undergoing haploidentical stem-cell transplantation. (nature.com)
  • The experimental treatment consists in the application of a therapeutic strategy of allogeneic transplantation using either a Marrow Unrelated Donor (MUD) or a Cord Blood (CB) unit or a family Haploidentical (Haplo) donor as a potential curative procedure in a population of patients with chemoresistant acute leukemias for increase the overall survival in this patients. (knowcancer.com)
  • Relapse of AML was diagnosed 14 months after the transplantation. (hindawi.com)
  • We analyzed the hematologic recovery, and risks of graft-versus-host disease (GVHD), transplantation-related mortality (TRM) and relapse, and disease-free survival (DFS) using Cox proportional hazards models. (elsevier.com)
  • In the clinic, I conduct trials designed to improve outcomes following allogeneic stem cell transplantation with an emphasis on reducing relapse risk and decreasing toxicities associated with transplantation. (ucdenver.edu)
  • Early CNS relapse carries a high risk of additional relapses, especially in the bone marrow, indicating the need for intensive systemic therapy, which may include hematopoietic stem cell (HSC) transplantation. (bioeticaweb.com)
  • Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival. (harvard.edu)
  • However, it also suggests cord-blood-derived stem cells are a safe and viable treatment option for a much broader range of diseases and conditions than previously thought. (news-medical.net)
  • These new findings could open up the use of cord blood for non-hematological diseases, something that to date has not been performed on a wide-spread basis. (news-medical.net)
  • This 1-year study will enroll individuals with advanced blood diseases or cancer. (clinicaltrials.gov)
  • PURPOSE: This phase II trial is studying how well umbilical cord blood works as a source of stem cells in treating patients with types of cancer as well as other diseases. (centerwatch.com)
  • BACKGROUND: Reduced intensity stem cell cell transplantation (RIST) from unrelated umbilical cord blood (RI-UCBT) is a novel therapeutic strategy for patients with malignant and non-malignant diseases, but infectious complications of this procedure have not been previously well described. (aspergillus.org.uk)
  • Besides this, they are found to be beneficial to treat variety of diseases such as Lou Gehrig, Stroke, Parkinson, Alzheimer as well as various types of spinal cord injuries. (nachoserapio.com)
  • According to the medical experts, cord blood transplantation helps the patient to fight successfully deadly diseases. (nachoserapio.com)
  • Umbilical cord blood (UCB) is an alternative hematopoietic stem cell (HSC) source that can ameliorate several diseases through transplantation. (wpi.edu)
  • Hematopoietic cells are perhaps the only type of adult stem cells that has firmly become the part of the arsenal of medical care for life-threatening diseases. (exp-oncology.com.ua)
  • In November 2004, California voters passed a ballot measure providing $3 billion for stem cell research to find cures for a plethora of degenerative diseases. (icr.org)
  • If these cells can provide a cure for many who suffer from degenerative diseases such as Parkinson's, Alzheimer's, and diabetes, why would anyone object to stem cell research and its applications? (icr.org)
  • Stem cell transplantation , also known as bone marrow transplantation, is used to treat blood diseases such as aplastic anemia, bone marrow failure, and blood cancers, as well as to restore blood-forming cells in the body. (bumrungrad.com)
  • This year event will be led by scientists and clinicians researching, developing and testing new treatments for genetically inherited and acquired diseases using gene delivery technology, stem cell manipulation and DNA repair techniques. (smi-online.co.uk)
  • citation needed] Myelokathexis is amongst the diseases treated with bone marrow transplantation and cord blood stem cells. (wikipedia.org)
  • abstract = "Alloantigen reactive cytotoxic T lymphocytes (CTL) were generated from cord blood (CB) lymphocytes used for cord blood stem cell transplantation (CBSCT). (fujita-hu.ac.jp)
  • This study provides evidence that mesenchymal stem cell transplantation could favorably impact a side effect of delivery and aging by releasing factors that can influence the urethra and vagina to treat stress urinary incontinence" said Dr Amit N. Patel, director of cardiovascular regenerative medicine at the University of Utah and section editor for Cell Transplantation . (medindia.net)
  • Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. (waterstones.com)
  • Because the protocol developed by Beike allows the use of cord blood stem cells without immune suppression, it can be made available to a wide patient population. (news-medical.net)
  • The VPA-treated cells produced a greater number of repopulating cells, and established multilineage hematopoiesis in primary, secondary and tertiary immune-deficient mice. (news-medical.net)
  • Umbilical cord blood is an important source of stem cells and can be used to treat blood and immune system disorders and certain types of cancer. (clinicaltrials.gov)
  • The purpose of this study is to examine the immune system response to cord blood stem cell transplantation in adults with advanced blood disorders or cancer. (clinicaltrials.gov)
  • At each visit, participants will have blood drawn for laboratory testing and for evaluation of immune system response. (clinicaltrials.gov)
  • RATIONALE: Umbilical cord blood transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. (centerwatch.com)
  • Compared with the cord blood CD34-positive cells, the valproic acid-treated CD34-positive cells produced a greater number of severe combined immunodeficiency-repopulating cells and established multilineage hematopoiesis in primary and secondary immune-deficient recipient mice. (ascopost.com)
  • This is because, immune cells found within the cord blood have been found to be less mature when compared to stem cells which are obtained from various other resources. (nachoserapio.com)
  • This study used MSCs, cells which are believed to be "immune-privileged," with no rejection issues. (medindia.net)
  • 7 Using stem cells from another niche in the body will make it possible to treat an individual who is suffering from organ failure with their own stem cells, eliminating an immune response that frequently leads to tissue rejection of a transplanted organ. (icr.org)
  • It will take 6 to 12 months or more for your child's blood counts and immune system to fully recover. (medlineplus.gov)
  • For decades, cord blood donation has served an important role in facilitating stem cell transplantation for the treatment of various blood and immune disorders. (stanford.edu)
  • CD4+T cells are composed of various subsets that each expresses a distinctive set of cytokines and can potently shift the immune response toward various directions. (urotoday.com)
  • The rationale for the use of HSCs in treating subjects with T1D is based upon the immunoregulatory properties of HSCs, which may help to rescue peripheral tolerance toward pancreatic β-cells by reshaping the immune response ( 13 , 14 ). (diabetesjournals.org)
  • We conduct translational studies designed to better understand immune reconstitution following transplantation and develop novel strategies to use the immune system to improve outcomes. (ucdenver.edu)
  • For example, we are the first team in the world to combine checkpoint inhibitors (drugs that work by inhibiting the proteins cancer cells use to evade detection by the immune system) after transplantation, at a time where the newly reset immune system has the best opportunity to eliminate residual cancer cells. (hackensackumc.org)
  • An alternative preventive strategy is to modify the regulatory components of the immune system - in particular, Foxp3+ regulatory T cells (Tregs). (mja.com.au)
  • Natural killer cells represent key cellular components of the innate immune system. (jimmunol.org)
  • The immune system and the blood system are closely linked and can't be separated from each other. (lls.org)
  • Because of this, allogeneic transplantation means that not only the donor's blood system but also his or her immune system is transferred. (lls.org)
  • Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation. (news-medical.net)
  • Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a single collection,' said Pratima Chaurasia, PhD, Assistant Professor of Medicine at the Tisch Cancer Institute at Mount Sinai. (news-medical.net)
  • Epigenetically reprogramming cord blood CD34-positive cells may decrease the high rate of graft failure in adult patients with hematologic cancers. (ascopost.com)
  • Human adult stem cells need to be investigated in future studies to see if these findings also apply to humans. (medindia.net)
  • They have concluded that both adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities. (medindia.net)
  • Application of UCB transplantation has previously been limited by low cell dose, particularly in adult patients. (docplayer.net)
  • Limited graft cell dose in adult recipients. (docplayer.net)
  • Szabolcs P, Park KD, Reese M, Marti L, Broadwater G, Kurtzberg J (2003) Coexistant naïve phenotype and higher cycling rate of cord blood T cells compared to adult peripheral blood. (springer.com)
  • Berthou C, Legros-Maida S, Soulie A et al (2003) Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes. (springer.com)
  • These data suggest that unrelated cord blood could be as safe and effective a stem-cell source as related bone marrow or mobilized peripheral blood for adult patients when it is used as a primary unrelated stem-cell source. (elsevier.com)
  • Stem cells persist throughout development and into the adult where they are referred to as multipotent adult stem cells. (icr.org)
  • Adult stem cells are capable of differentiating into one of several (multipotent) cell types, but presumably not into any cell type (although this dogma is now being challenged). (icr.org)
  • Multipotent adult stem cells can be found in many regions of the body called stem cell niches and collecting cells from these niches neither creates a viable embryo nor harms the donor. (icr.org)
  • The haemopoietic stem cells found in bone marrow provide a good example of adult stem cell function. (icr.org)
  • 4 Additional adult stem cells found in bone marrow, the mesenchymal cells, differentiate into bone, cartilage, and fat cells. (icr.org)
  • This chapter summarizes the advantages and disadvantages of CB compared to adult stem cells within the context of stem cell biology and transplantation. (frontiersin.org)
  • Cord blood units, unlike adult donor stem cell collection/harvests, are readily available on demand. (frontiersin.org)
  • The use of umbilical cord blood for hematopoietic stem cell transplantation has been associated with less severe graft-versus-host disease (GVHD) than when the donor is an adult. (medpagetoday.com)
  • Results to date of umbilical cord blood transplantation in adult and fully mature adolescent patients are inferior to what is seen in children. (knowcancer.com)
  • Only a minority of adult patients will have a suitably matched umbilical cord blood unit that contains more than 1.5 x 107 nucleated cells/kg. (knowcancer.com)
  • The second reason for inferior outcome of umbilical cord blood transplantation in adult patients is that in comparison to children, the conventional myeloablative bone marrow conditioning regimens are more toxic. (knowcancer.com)
  • For more than 25 years, physicians in the Adult Blood and Marrow Stem Cell Transplantation Program at John Theurer Cancer Center, part of Hackensack University Medical Center in New Jersey, have provided this lifesaving therapy. (hackensackumc.org)
  • In addition, the transparency of the embryos has enabled real-time visualization of the emergence, migration, and behavior of blood cells as they populate the embryo and adult, both during endogenous development and upon various chemical or genetic perturbations. (rupress.org)
  • As a matter of fact, stem cells are known to have the capability to multiply itself to recreate other types of cells such as platelets, white blood cells and red blood cells. (nachoserapio.com)
  • Results in children have clearly shown that the number of nucleated cells in the infused cord blood influences the speed of recovery of neutrophils and platelets after myeloablative chemotherapy. (who.int)
  • These cells can differentiate into various blood cell types including erythrocytes (red blood cells), thrombocytes (platelets), and several types of leucocytes (white blood cells). (icr.org)
  • You may get transfusions of irradiated blood products, such as platelets and red blood cells. (mskcc.org)
  • A complete blood count revealed white blood cells at 98 x 10 9 /L, hemoglobin at 100 g/L, and platelets at 15 x 10 9 /L. Bone marrow examination showed 94% lymphoblasts with L-1 morphology. (bioeticaweb.com)
  • Stem cells produce red blood cells, white blood cells, and platelets. (lahey.org)
  • Additionally, a perfect donor match is not necessary, thereby decreasing the likelihood of graft-versus-host disease (GVHD), a serious side effect in which donor stem cells attack the recipient's tissues. (clinicaltrials.gov)
  • It may take about a month for the donor stem cells in the bone marrow to begin to function fully. (lahey.org)
  • This is to prevent your body from rejecting the donor stem cells. (lahey.org)
  • Treating cord blood cells that express CD34 with a combination of histone deacetylase inhibitors and valproic acid increases the number of multipotent cells of functional cord blood stem cells for use as transplantation grafts. (ascopost.com)
  • Following conditioning, up to two unrelated, partially matched umbilical cord blood grafts will be infused that will provide a minimum nucleated cell dose of 3 x 10e7/kg. (knowcancer.com)
  • The authors describe a method for percutaneous transplantation of human umbilical cord blood (hUCB)-derived multipotent stem cells (MSCs) under fluoroscopic guidance. (thejns.org)
  • Because there is little research on the effects of transplanted stem cells on neuronal metabolites in infarct areas, we transplanted human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) into cerebral ischemic rabbits and examined the neuronal metabolites. (biomedcentral.com)
  • Combining either umbilical cord blood transplantation or peripheral stem cell transplantation with antiviral therapy may be an effective treatment for HIV-positive patients who have hematologic cancer. (clinicaltrials.gov)
  • PURPOSE: Phase I trial to study the effectiveness of antiviral therapy plus either peripheral stem cell transplantation or umbilical cord blood transplantation in treating HIV-positive patients who have refractory or recurrent hematologic cancer. (clinicaltrials.gov)
  • HEMATOPOIETIC STEM CELL TRANSPLANTATION has been used for many years to treat various malignant and nonmalignant hematologic conditions. (cmaj.ca)
  • Advances in hematopoietic stem cell transplantation have made this approach an option for more people with hematologic cancers and benign blood disorders, including older patients and those with multiple medical issues. (hackensackumc.org)
  • In a number of genetic, hematologic, immunologic, metabolic, and oncologic disorders, reconstitution of bone marrow (transplantation) can be a potentially life-saving procedure. (aappublications.org)
  • Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. (harvard.edu)
  • Infectious Complications in Patients Undergoing Reduced Intensity Stem Cell Transplantation (RIST) from Unrelated Umbilical Cord Blood (RI-UCBT). (aspergillus.org.uk)
  • In contrast, diagnosing vascular complications in patients undergoing SCT is challenging, and damage to endothelial cells is regarded as the common feature of these complications. (nature.com)
  • Many prominent individuals made pleas for the passage of this measure including California Governor Arnold Schwarzenegger, former First Lady Nancy Reagan, and actors Michael J. Fox, who suffers from Parkinson's Disease (PD), and Christopher Reeve, who died recently of complications from a spinal cord injury suffered several years ago. (icr.org)
  • Unfortunately, exogenous insulin therapy does not always achieve the necessary metabolic control ( 4 ), nor does it prevent the occurrence of disease-associated degenerative macrovascular and microvascular complications ( 5 ) or halt β-cell decline ( 6 ). (diabetesjournals.org)
  • Our research has a strong focus on reducing the complications of transplantation and also lowering the risk of recurrence. (hackensackumc.org)
  • Among many sources of hematopoietic stem cell sources, cord blood (CB) is the one that belongs to the earliest stages of life. (frontiersin.org)
  • The use of autologous cord blood (when available) for HSC transplantation is a challenging and controversial matter. (bioeticaweb.com)
  • In this report we describe a case of autologous cord blood transplantation for treatment of relapsed ALL and discuss the feasibility and safety of such a procedure. (bioeticaweb.com)
  • A pilot trial is currently underway in Australia to examine whether infusion of autologous cord blood can prevent type 1 diabetes in high-risk children with serum antibodies to multiple β -cell antigens. (mja.com.au)
  • This is the first time such a trial will be undertaken for the prevention of type 1 diabetes in humans, although studies have used autologous cord blood after the onset of type 1 diabetes. (mja.com.au)
  • In a Phase I trial involving 24 children (median age, 5.1 years) with type 1 diabetes, 9 infusion of autologous cord blood after a median diabetes duration of 3 months was associated with a transient increase in total and naive Tregs at 6 and 9 months, respectively. (mja.com.au)
  • Gene-therapy research involving modification of autologous cord blood stem cells for the treatment of childhood genetic disorders, although experimental at the present time, may prove to be of value. (aappublications.org)
  • These scientific advances have resulted in the establishment of not-for-profit and for-profit cord blood-banking programs for allogeneic and autologous cord blood transplantation. (aappublications.org)
  • Amongst the benefits of CB, compared to bone marrow (BM) and mobilized peripheral blood (MPB), as a source of engrafting HSC and HPC are its ready availability through CB banks, and a relatively low level of graft vs. host disease (GVHD) elicited after transplantation. (stembook.org)
  • Therapeutic intervention, namely the conditioning regimen as well as GVHD prophylaxis, are based on regimens currently in standard use in the context of allogeneic transplantation. (knowcancer.com)
  • In comparing the histologic findings associated with the cord colitis syndrome with findings in GVHD, the authors noted that in GVHD there is no granuloma formation, epithelial infiltration, or metaplasia of Paneth cells as was seen in the new syndrome. (medpagetoday.com)
  • Unfortunately, T lymphocytes are the same cells that cause graft versus host disease (GVHD) . (lls.org)
  • Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial. (harvard.edu)
  • The results also suggest that transplantation of hUCB-derived MSCs may have therapeutic effects that decrease cavitation for acute SCI. (thejns.org)
  • The HSC transplantation therapeutic approach pioneered by the Pesaro group 5 - 11 is now applied widely worldwide. (haematologica.org)
  • Marked changes in liver histopathology and serological markers of liver function have been observed without a clear understanding of the therapeutic mechanism by which stem cells act. (scienceopen.com)
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
  • What is the state of stem cell research in the different therapeutic segments? (benzinga.com)
  • The book also explores possible future uses for stem cell transplantation and other therapeutic applications. (waterstones.com)
  • The latest developments in cell and gene therapies and specifically in gene editing technologies present unlimited research opportunities ranging from novel therapeutic tools to a potential revolution in the field of drug discovery. (smi-online.co.uk)
  • After the chemotherapy and/or radiation, the peripheral stem cell transplantation will be administered. (bumrungrad.com)
  • Thalassemia major and sickle cell disease are the two most widely disseminated hereditary hemoglobinopathies in the world. (haematologica.org)
  • Thalassemia major (TM) originated in Mediterranean, Middle Eastern, and Asian regions, and sickle cell disease (SCD) originated from throughout central Africa. (haematologica.org)
  • Allogeneic hemopoietic stem cell (HSC) transplantation in thalassemia major has been a cornerstone of the development of cell-based therapies 1 and a matter of passionate debate during the '80s and early '90s. (haematologica.org)
  • 2 The aim of HSC transplantation in thalassemia is to replace the ineffective endogenous thalassemic erythropoiesis with an effective allogeneic substitute and to obtain a lasting, permanent, clinically effective correction of the hemolytic anemia 3 , 4 and of the transfusion-associated pathologies, including iron overload. (haematologica.org)
  • http://www.medisteminc.com ), reported positive safety data in 114 patients who were treated by doctors at Nanshan Affiliated Hospital of Guangdong Medical College (Shenzhen Nanshan Hospital) in Shenzhen using Beike's proprietary cord blood stem cell transplantation protocol. (news-medical.net)
  • Dr. Travis Ye, Beike Biotech's CEO, commented, 'This groundbreaking research is consistent with the safety record we have compiled after providing stem cells for the treatment of more than 8,000 patients. (news-medical.net)
  • BPCBR was born from this altruistic desire to advance discovery by bringing patients, clinicians, and researchers together in pursuit of a novel and ambitious endeavor: a non-profit, sustainable initiative that would provide Stanford researchers with umbilical cord blood for years to come. (stanford.edu)
  • Cord blood has been used successfully in pediatric patients but its benefit in adults remains untested. (clinicaltrials.gov)
  • 18 patients (39%) died before day 100 after transplantation. (aspergillus.org.uk)
  • Functional improvement of patients with progressive muscular dystrophy by bone marrow and umbilical cord blood mesenchymal stem cell transplantations]. (semanticscholar.org)
  • Peripheral blood as a preferable source of stem cells for salvage transplantation in patients with graft failure after cord blood transplantation: a retrospective analysis of the registry data of the Japanese Society for Hematopoietic Cell Transplantation. (nature.com)
  • The European Group for Blood and Marrow Transplantation (EBMT) has established the hemoglobinopathy registry which now contains detailed epidemiological data on over 3,000 patients. (haematologica.org)
  • The stem cell source was BM in ten patients and UCB in three. (elsevier.com)
  • This case suggests that CB T cells may be competent enough to generate CTL to induce a GVL effect, together with those against A*0206, in patients with CBSCT. (fujita-hu.ac.jp)
  • Based on our analysis, the liver function of LC patients was significantly improved after USCs transplantation and RST combined therapy, indicated by decreased total bilirubin, alanine aminotransferase, aspartate aminotransferase levels and prothrombin time and increased serum albumin level and prothrombin activity. (scienceopen.com)
  • USCs transplantation is a safe and effective adjuvant therapy for RST-treated LC, possibly through improving patients' liver function. (scienceopen.com)
  • Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. (scienceopen.com)
  • Hence, CB offers an advantage for patients in need of urgent transplantation. (frontiersin.org)
  • As CBTs can be performed with a 4-6/6 match, this presents a chance of transplantation for patients who possess rare HLA types, i.e., who belong to ethnical groups not well-represented in registries or who belong to different race admixture families. (frontiersin.org)
  • A new syndrome characterized by watery diarrhea has been identified in a group of patients who underwent cord blood stem cell transplantation. (medpagetoday.com)
  • The condition, termed cord colitis syndrome, developed in 11 of 104 patients, according to a retrospective study done by Alex F. Herrera, MD, of Brigham and Women's Hospital in Boston, and colleagues. (medpagetoday.com)
  • Our aim is to provide updated results on the worldwide use of autologous HSC transplantation (AHSCT) in T1D patients, to evaluate potential adverse events, and to explore the successes and potential pitfalls of this novel therapy. (diabetesjournals.org)
  • Treosulfan, Fludarabine and 2 Gy Total Body Irradiation Followed by Allogeneic Hematopoietic Cell Transplantation in Patients with MDS and AML. (ucdenver.edu)
  • It is stated to be a procedure where 'Master Cells' get transfused into the patient's body. (nachoserapio.com)
  • A wonderful aspect pertaining to this transplantation procedure is that there is no need for having that perfect match with the patient. (nachoserapio.com)
  • The other aspect is that the patient undergoing this cord blood transplantation procedure is found to be at less risk to contract infections during transfusion. (nachoserapio.com)
  • Cord blood as a source of hematopoietic stem cells (HSC) has several advantages as it is easily available, involves non-invasive collection procedure and is better tolerated across the HLA barrier. (who.int)
  • This procedure is done if the stem cells in your bone marrow are not functioning or are deficient. (lahey.org)
  • Allogeneic stem cell transplantation can be a high-risk procedure. (lls.org)
  • To motivate, empower and enlighten people with an interest in bone marrow transplantation through peer support, education and awareness of this difficult but potentially life-saving procedure. (lls.org)
  • The investigators then tested whether percutaneous transplantation of hUCB-derived MSCs improved neurological functional recovery after acute spinal cord injury (SCI). (thejns.org)
  • DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction. (nih.gov)
  • Analysis of risk factors for acute cutaneous graft-versus-host disease after allogeneic stem cell transplantation. (springer.com)
  • Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease. (springer.com)
  • Histological examination showed acute focal tubular necrosis, the renal corpuscles showed thickened membranes, changes in Bowman's capsule parietal cells and effacement of podocyte foot processes and the interstitium showed mononuclear cellular infiltration. (lww.com)
  • Acute and latent human CMV cause profound changes in the NK cell repertoire, with expansion and differentiation of educated NK cells expressing self-specific inhibitory killer cell Ig-like receptors. (jimmunol.org)
  • Intriguingly, selected populations of NK cells undergo dynamic expansion and functional reprogramming as a result of acute and latent viral infections in a fashion much resembling T cell responses ( 5 , 6 ). (jimmunol.org)
  • This review is intended as a basic overview of allogeneic and autologous stem cell transplantation with a special focus on long-term follow-up issues relevant to primary care providers. (cmaj.ca)
  • 7 , 8 In addition, these microparticles have more recently been shown to reflect in vitro cell stimulation, and testify to cellular activation and/or tissue degeneration occurring in vivo under a variety of pathophysiologic circumstances. (nature.com)
  • Many groups have investigated their potential role in tolerance induction and/or restoration, in pancreatic tissue remodelling as "feeder" cells and in direct differentiation into insulin-producing cells, with the shared final goal to preserve β cell function. (nystemcelltherapy.com)
  • Co-holder of a £2 million grant from Wellcome Trust/MRC to fund the Human Developmental Biology Resource and holder of grant from Kavli Foundation to provide tissue for single cell atlas of developing brain. (ncl.ac.uk)
  • Five weeks after the start of the experiment, urine and blood samples were collected for biochemical investigation and kidney tissue was used for histological examination. (lww.com)
  • Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. (waterstones.com)
  • These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. (waterstones.com)
  • First, you and your siblings, if any, will have your blood or a scraping from your inside cheek tested to determine tissue type. (lls.org)
  • A lab technician examines the surface of the sample tissue cells to identify the proteins that give everyone his or her own unique tissue type, called human leukocyte antigens (HLAs). (lls.org)
  • Newborn Possibilities Program® offers free cord blood and tissue processing and five years of storage to qualifying families in the U.S. (lls.org)
  • Stem cell transplantation strategies are typically considered in the setting of ______________ indolent lymphoma. (mdedge.com)
  • There is great interest in stem cells because they have potential to replace defective or damaged cells resulting from a variety of disorders and injuries, leading to a range of new regenerative therapies. (fiercebiotech.com)
  • stem cells may also eventually permit drug developers to test emerging therapies on diseased cells. (fiercebiotech.com)
  • Stem cell therapies may be more feasible and less invasive than current therapies. (medindia.net)
  • Therefore, elucidation of potential mechanisms of action is vital to further develop stem cell therapies for translation to the bedside. (biomedcentral.com)
  • What are the revenue prospects for some of the stem cell therapies which have already been approved? (benzinga.com)
  • making Frontiers of Cord Blood Science a valuable reference for researchers and clinicians who are interested in the evolving field of cellular therapies. (waterstones.com)
  • Graft failure (GF) remains a major complication of cord blood transplantation (CBT). (nature.com)
  • Ozdemir ZN, Civriz Bozdag S. Graft failure after allogeneic hematopoietic stem cell transplantation. (nature.com)
  • Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation. (nature.com)
  • Multiple studies have suggested that a nucleated cell dose below 1.5 to 2 x 107/kg results in an unacceptably high risk for graft failure. (knowcancer.com)
  • Umbilical cord blood (CB) has been rapidly established as an alternative source of stem cells to bone marrow for allogeneic-related and unrelated hematopoietic transplantation. (nih.gov)
  • A recent survey by Bernadette Model indicated that over 330,000 hemoglobinopathy affected infants are born annually (83% sickle cell disorders, 17% thalassemias). (haematologica.org)