Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Unstable isotopes of zinc that decay or disintegrate emitting radiation. Zn atoms with atomic weights 60-63, 65, 69, 71, and 72 are radioactive zinc isotopes.
A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Unstable isotopes of krypton that decay or disintegrate emitting radiation. Kr atoms with atomic weights 74-77, 79, 81, 85, and 87-94 are radioactive krypton isotopes.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Unstable isotopes of barium that decay or disintegrate emitting radiation. Ba atoms with atomic weights 126-129, 131, 133, and 139-143 are radioactive barium isotopes.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.
Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.
Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.
High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.
Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.
Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.
Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.
Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.
Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.
Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.
Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Pollutants, present in soil, which exhibit radioactivity.
Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)
Unstable isotopes of bromine that decay or disintegrate emitting radiation. Br atoms with atomic weights 74-78, 80, and 82-90 are radioactive bromine isotopes.
Detection and counting of scintillations produced in a fluorescent material by ionizing radiation.
Leakage and accumulation of CEREBROSPINAL FLUID in the subdural space which may be associated with an infectious process; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; INTRACRANIAL HYPOTENSION; and other conditions.
Stable calcium atoms that have the same atomic number as the element calcium, but differ in atomic weight. Ca-42-44, 46, and 48 are stable calcium isotopes.
Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.
Techniques used to determine the age of materials, based on the content and half-lives of the RADIOACTIVE ISOTOPES they contain.
Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. It is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.
A series of steps taken in order to conduct research.
Determination of the energy distribution of gamma rays emitted by nuclei. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A specialty field of radiology concerned with diagnostic, therapeutic, and investigative use of radioactive compounds in a pharmaceutical form.
A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.
Intrauterine contraceptive devices that depend on the release of metallic copper.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Uptake of substances through the lining of the INTESTINES.
Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.
A form species of spore-producing CYANOBACTERIA, in the family Nostocaceae, order Nostocales. It is an important source of fixed NITROGEN in nutrient-depleted soils. When wet, it appears as a jelly-like mass.
Measurement of radioactivity in the entire human body.
Unstable isotopes of potassium that decay or disintegrate emitting radiation. K atoms with atomic weights 37, 38, 40, and 42-45 are radioactive potassium isotopes.
A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.
A bacterial protein from Pseudomonas, Bordetella, or Alcaligenes which operates as an electron transfer unit associated with the cytochrome chain. The protein has a molecular weight of approximately 16,000, contains a single copper atom, is intensively blue, and has a fluorescence emission band centered at 308nm.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

67Cu-2IT-BAT-Lym-1 pharmacokinetics, radiation dosimetry, toxicity and tumor regression in patients with lymphoma. (1/245)

Lym-1, a monoclonal antibody that preferentially targets malignant lymphocytes, has induced therapeutic responses and prolonged survival in patients with non-Hodgkin's lymphoma when labeled with 1311. Radiometal-labeled antibodies provide higher tumor radiation doses than corresponding 1311 antibodies. 67Cu has an exceptional combination of properties desirable for radioimmunotherapy, including gamma and beta emissions for imaging and therapy, respectively, a biocompatible half-time and absence of pathways contributing to myelotoxicity. The radioimmunoconjugate, 67Cu-21T-BAT-Lym-1, has been shown to be efficacious in nude mice bearing human Burkitt's lymphoma (Raji) xenografts. Based on these results, a clinical study of the pharmacokinetics and dosimetry of 67Cu-21T-BAT-Lym-1 in patients with lymphoma was initiated. METHODS: Eleven patients with advanced stage 3 or 4 lymphoma were given a preload dose of unmodified Lym-1, then an imaging dose of 126-533 MBq (3.4-14.4 mCi) 67Cu-21T-BAT-Lym-1. Total Lym-1 ranged from 25 to 70 mg dependent on the specific activity of the radioimmunoconjugate and was infused at a rate of 0.5-1 mg/min. Imaging, physical examination, including caliper measurement of superficial tumors, and analysis of blood, urine and fecal samples were performed for a period of 6-13 d after infusion to assess pharmacokinetics, radiation dosimetry, toxicity and tumor regression. RESULTS: In 7 patients, in whom superficial tumors had been accurately measured, tumors regressed from 18% to 75% (mean 48%) within several days of 67Cu-21T-BAT-Lym-1 infusion. The uptake and biological half-time of 67Cu-21T-BAT-Lym-1 in tumors were greater than those of normal tissues, except the mean liver half-time exceeded the mean tumor half-time. The mean tumor-to-marrow radiation ratio was 32:1, tumor-to-total body was 24:1 and tumor-to-liver was 1.5:1. Images were of very good quality; tumors and normal organs were readily identified. Mild and transient Lym-1 toxicity occurred in 6 patients; 1 patient developed a human antimouse antibody. There were no significant changes in blood counts or serum chemistries indicative of radiation toxicity. CONCLUSION: Because of the long residence time of 67Cu-21T-BAT-Lym-1 in tumors, high therapeutic ratios were achieved and, remarkably, numerous tumor regressions were observed after imaging doses. The results indicate considerable therapeutic potential for 67Cu-21T-BAT-Lym-1.  (+info)

67Cu-versus 131I-labeled Lym-1 antibody: comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma. (2/245)

Antilymphoma mouse monoclonal antibody (MoAb) Lym-1, labeled with 67Cu or 131I, has demonstrated promising results in radioimmunotherapy (RIT) for lymphoma. Although 131I has played a central role in RIT thus far, some properties of 67Cu are preferable. A subset of our patients received both 67Cu- and 131I-labeled Lym-1, allowing a comparative evaluation of the two radiopharmaceuticals administered to a matched population of patients. Four patients with B-lymphocytic non-Hodgkin's lymphoma that had progressed despite standard therapy entered trials of 67Cu- and 131I-labeled Lym-1, which were injected 3-26 days apart. Lym-1 was conjugated to 6-[p-(bromoacetamido)benzyl]-1,4,7,11-tetraazacyclotetradecane-N,N ',N",N'"-tetraacetic acid (BAT) via 2-iminothiolane (2IT) and radiolabeled with 67Cu to prepare 67Cu-2IT-BAT-Lym-1; 131I-Lym-1 was preparred by the chloramine-T reaction. Planar imaging was used to quantitate 67Cu-2IT-BAT-Lym-1 or 131I-Lym-1 in organs and tumors daily for 3 days or longer. 67Cu-2IT-BAT-Lym-1 exhibited higher peak concentration in 92% (12 of 13) of tumors and a longer biological half-time in every tumor than 131I-Lym-1. The mean tumor concentration (%ID/g) of 67Cu-2IT-BAT-Lym-1 was 1.7, 2.2, and 2.8 times that of 131I-Lym-1 at 0, 24, and 48 h after injection, respectively. The mean biological half-times of 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 in tumor were 8.8 and 2.3 days, respectively. Consequently, the mean tumor radiation dose delivered by 67Cu-2IT-BAT-Lym-1 was twice that of 131I-Lym-1, 2.8 (range 0.8-6.7), and 1.4 (range 0.4-35) Gy/GBq, respectively. 67Cu-2IT-BAT-Lym-1 delivered a lower marrow radiation dose than 131I-Lym-1; hence, the tumor:marrow therapeutic indices were 29 and 9.7, respectively. Radiation doses from 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 to normal tissues were similar except for liver, which received a higher dose from 67Cu-2IT-BAT-Lym-1. Images obtained with 67Cu-2IT-BAT-Lym-1 were superior. Radiation dosimetry data for 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 agreed with corresponding data from the larger populations of patients from which the matched population for the current study was drawn. In conclusion, 67Cu-2IT-BAT-Lym-1 given to non-Hodgkin's lymphoma patients in close temporal proximity to 131I-Lym-1 exhibited greater uptake and longer retention in tumor, resulting in higher radiation dose and therapeutic index than 131I-Lym-1. These as well as other factors suggest that 67Cu-2IT-BAT-Lym-1 may be superior to 131I-Lym-1 for RIT.  (+info)

Practical determination of patient-specific marrow dose using radioactivity concentration in blood and body. (3/245)

Accurate determination of red marrow radiation is important because myelotoxicity is often dose limiting in radioimmunotherapy. The S-value methodology assumes a fixed red marrow mass as defined by the standard Medical Internal Radiation Dose (MIRD) mathematic phantom. Substantial error can be introduced in marrow radiation estimates because red marrow mass varies from patient to patient. In this work we describe a patient-specific marrow dosimetry methodology that does not require an explicit estimate of marrow mass. METHODS: Photon radiation to marrow from all sources can be considered as the total body to marrow. Based on photon radiation from body and electron radiation from blood, a patient-specific marrow dose can be determined by counting blood and total body radioactivity and measuring body weight. RESULTS: The deviation in marrow dose calculation using total body to represent all photon radiation was 3.9% in 66 patients administered 131I-labeled antibodies and was 9.1% in 18 patients administered 67Cu-labeled antibodies. The differences between this patient-specific approach and estimates based on standard anatomy were considerable, ranging from -35% to 88%. The differences were greater when patients' weights differed substantially from the MIRD reference man phantom. CONCLUSION: For radiopharmaceuticals that do not bind marrow, patient-specific marrow dosimetry can be independent of the actual marrow mass of a patient. Patient-specific marrow dosimetry can be determined using radioactivity concentration in blood and body.  (+info)

Targeting superficial bladder cancer by the intravesical administration of copper-67-labeled anti-MUC1 mucin monoclonal antibody C595. (4/245)

PURPOSE: More effective intravesical agents are required to limit the recurrence and progression of superficial bladder cancer. This study assessed the ability of copper-67 ((67)Cu)-C595 murine antimucin monoclonal antibody to bind selectively to superficial bladder tumors when administered intravesically, with a view to its development for therapy. PATIENTS AND METHODS: Approximately 20 MBq of (67)Cu-C595 monoclonal antibody was administered intravesically to 16 patients with a clinical indication of superficial bladder cancer. After 1 hour, the bladder was drained and irrigated. Tissue uptake was assessed by imaging and by the assay of tumor and normal tissues obtained by endoscopic resection. RESULTS: Tumor was correctly identified in the images of 12 of 15 patients who were subsequently found to have tumors. Assay of biopsy samples at 2 hours showed a mean tumor uptake of 59.4% of the injected dose per kilogram (SD = 48.0), with a tumor-to-normal tissue ratio of 14.6:1 (SD = 20). After 24 hours (n = 5), this decreased to 4.3% of the injected dose per kilogram (SD = 2.9), with a tumor-to-normal tissue ratio of 1.8:1 (SD = 0.8). CONCLUSION: This study indicates a promising method for the treatment of superficial bladder cancer. Although the mean initial tumor uptake was high, effective therapy of bladder tumors will require an increased retention of the cytotoxic radionuclide in tumor tissue.  (+info)

CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. (5/245)

The copA gene product, a putative copper-translocating P-type ATPase, has been shown to be involved in copper resistance in Escherichia coli. The copA gene was disrupted by insertion of a kanamycin gene through homologous recombination. The mutant strain was more sensitive to copper salts but not to salts of other metals, suggesting a role in copper homeostasis. The copper-sensitive phenotype could be rescued by complementation by a plasmid carrying copA from E. coli or copB from Enterococcus hirae. Expression of copA was induced by salts of copper or silver but not zinc or cobalt. Everted membrane vesicles from cells expressing copA exhibited ATP-coupled accumulation of copper, presumably as Cu(I). The results indicate that CopA is a Cu(I)-translocating efflux pump that is similar to the copper pumps related to Menkes and Wilson diseases and provides a useful prokaryotic model for these human diseases.  (+info)

Performance of a 62Zn/62Cu generator in clinical trials of PET perfusion agent 62Cu-PTSM. (6/245)

The 62Zn/62Cu PET generator can be inexpensively produced and distributed from a single production site operating under typical good manufacturing practice guidelines. It therefore has the potential to greatly facilitate development of clinically practical PET. We report generator performance in a study in which 62Cu-pyruvaldehyde-bis(n4-methylthiosemicarbazone (PTSM) myocardial perfusion imaging is compared with 99mTc-sestamibi in the diagnosis of coronary artery disease. The 62Zn/62Cu generator is an improved version of a previously reported system that employs automated synthesis of 62Cu-PTSM. With this approach, the cumbersome step of 18C purification has been eliminated. METHODS: The 62Zn (9.3 h half-life) parent isotope is prepared by proton bombardment of natural copper at 33 MeV. A typical target irradiated with 37.5 microA/h is delivered by 12:00 PM on the day it is to be processed. Purified 62Zn obtained from the target is loaded onto the generator column in 2 mol/L HCl. The generator is eluted using an internal three-channel peristaltic pump, which delivers 2.25 mL eluant (1.8 mol/L NaCl, 0.2 mol/L HCl) through the generator column to elute the 62Cu in 40 s. The same pump simultaneously pumps an equal volume of buffer (0.4 mol/L NaOAc) and 1 mL ligand solution (2 ppm PTSM, 2% EtOH) passing it through a septum into a 35-cc syringe preloaded with 28 mL sterile water. This solution is thoroughly mixed by agitation of the syringe and injected as a bolus through a 0.2 microm filter. The generator is eluted twice before shipping, providing quality assurance samples, and shipped to the clinical site by overnight delivery. Complete quality assurance testing is performed the evening before the generator reaches the clinical site. RESULTS: A total of 34 generators have been produced and shipped to 2 clinical sites for a phase III Food and Drug Administration study. The load activity on the generators at 8:00 AM the day of clinical use was 1.7+/-0.2 GBq (46.7+/-5.6 mCi), and yield was 72%+/-16%. Breakthrough of 62Zn was undetectable by high-purity germanium spectroscopy for all units. Radiochemical purity was 95.4%+/-2.4%. Volume delivered, pH, sterility, and bacterial endotoxin tests yielded passing results on all generators. The entire process of generator production, from target receipt to generator shipment, took less than 6 h and cost approximately $1000, including shipping charges and cyclotron cost. A total of 68 patients were injected with 2 62Cu-PTSM doses, with a mean injected activity of 0.8+/-0.2 GBq (20.5+/-5.3 mCi) with no adverse side effects. CONCLUSION: Results of this work confirm that the 62Zn/62Cu generator is an easily produced, transportable, and inexpensive source of PET radiopharmaceuticals, which can expand the field of clinical PET imaging by providing radiopharmaceuticals to sites not associated with cyclotrons.  (+info)

High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. (7/245)

Rapid imaging by antitumor antibodies has been limited by the prolonged targeting kinetics and clearance of labeled whole antibodies. Genetically engineered fragments with rapid access and high retention in tumor tissue combined with rapid blood clearance are suitable for labeling with short-lived radionuclides, including positron-emitting isotopes for positron-emission tomography (PET). An engineered fragment was developed from the high-affinity anticarcinoembryonic antigen (CEA) monoclonal antibody T84.66. This single-chain variable fragment (Fv)-C(H)3, or minibody, was produced as a bivalent 80 kDa dimer. The macrocyclic chelating agent 1,4,7, 10-tetraazacyclododecane-N,N',N", N"'-tetraacetic acid (DOTA) was conjugated to the anti-CEA minibody for labeling with copper-64, a positron-emitting radionuclide (t(1/2) = 12.7 h). In vivo distribution was evaluated in athymic mice bearing paired LS174T human colon carcinoma (CEA positive) and C6 rat glioma (CEA negative) xenografts. Five hours after injection with (64)Cu-DOTA-minibody, microPET imaging showed high uptake in CEA-positive tumor (17.9% injected dose per gram +/- 3.79) compared with control tumor (6.0% injected dose per gram +/- 1.0). In addition, significant uptake was seen in liver, with low uptake in other tissues. Average target/background ratios relative to neighboring tissue were 3-4:1. Engineered antibody fragments labeled with positron-emitting isotopes such as copper-64 provide a new class of agents for PET imaging of tumors.  (+info)

Gastrointestinal uptake and distribution of copper in rainbow trout. (8/245)

A single dose of radioactive copper ((64)Cu or new Cu) was infused into the stomach of rainbow trout (Oncorhynchus mykiss) to model dietary copper (Cu) uptake under conditions of a normal nutritional dose and optimum environmental temperature (16 degrees C, 0.117 microg Cu g(-)(1 )body mass). The distribution of new Cu to the gut and internal organs occurred in two phases: rapid uptake by the gut tissues (almost complete by 24 h post-infusion) followed by slower uptake by the internal organs. By 72 h, 60 % of the dose had been excreted, 19 % was still retained in the gut tissue, 10 % remained in the lumen and 12 % had been absorbed across the gut and partitioned amongst the internal organs. A reduction in water temperature of 10 degrees C (to 6 degrees C) significantly retarded components of new Cu distribution (movement of the bolus along the gut and excretion); nonetheless, by 72 h, the fraction absorbed by all the internal organs was similar to that at 16 degrees C. An increase in water temperature of 3 degrees C (to 19 degrees C) caused a pronounced increase in internal organ uptake by 24 h to approximately double the uptake occurring at 16 degrees C. The uptake of new Cu by the gut tissue had a low temperature coefficient (Q(10)<1) consistent with simple diffusion, while the temperature coefficient for transfer of new Cu from gut tissue to the internal organs was high (Q(10)>2), consistent with facilitated transport. Internally, the liver and gall bladder (including bile) were the target organs for dietary Cu partitioning since they were the only organs that concentrated new Cu from the plasma. Individual tissues differed in terms of the exchange of their background Cu pools with new Cu. The background Cu in the walls of the gastrointestinal tract (excluding stomach) exchanged 45-94 % with new Cu from the gut lumen, while tissues such as the stomach, gills, kidney, carcass and fat had 5-7 % exchangeable background Cu. The liver, heart, spleen, ovary, bile and plasma had only 0.2-0.8 % exchangeable background Cu. The gastrointestinal tissues appear to act as a homeostatic organ, regulating the absorption of nutritional (non-toxic) doses of Cu (0. 117 microg g(-)(1 )body mass day(-)(1)) by the internal organs. Within the dose range we used and at optimal temperature (16 degrees C), the new Cu content of the gut tissues fluctuated, but absorption of new Cu by the internal organs remained relatively constant. For example, predosing the fish with non-radioactive Cu caused new Cu absorption by the gut tissues to double and decreased new Cu excretion from 38 to 1.5 %, but had no effect on new Cu uptake by the internal organs. Feeding fish after application of the normal liquid dose of new Cu also had no effect on new Cu uptake by the internal organs, even though the presence of food in the digestive tract reduced the binding of new Cu to the gut tissues and assisted with the excretion of new Cu. The gut was therefore able to regulate new Cu internalization at this dosage. Higher new Cu doses (10, 100 and 1000 times the normal dose), however, evoked regurgitation and increased new Cu excretion within 4 h of application but did not elevate new Cu levels in gut tissue beyond a threshold of approximately 40 microg of new Cu. Only at the highest dose (1000 times the normal dose, 192 microg g(-)(1 )body mass), equivalent to toxic concentrations in the daily diet (7000 microg Cu g(-)(1 )dry mass food), was the buffering capacity of the gut overwhelmed, resulting in an increase in internal new Cu uptake.  (+info)

Improved bifunctional chelating agents (BFC) are required for copper-64 radiolabelling of monoclonal antibodies (mAbs) under mild conditions to yield stable, target-specific imaging agents. Four different bifunctional chelating agents (BFC) were evaluated for Fab (Fragment antigen binding) conjugation and radiolabelling with copper-64. Two DOTA- (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and two NOTA- (1,4,7-triazacyclononane-1,4,7-triacetic acid) derivatives bearing a p-benzyl-isothiocyanate group were conjugated to Fab-trastuzumab - which targets the HER2/neu receptor - and the average number of chelators attached ranged from 2.4 to 4.3 macrocycles per Fab. Labelling of the immunoconjugate with copper-64 was achieved in high radiochemical yields after 45 min at 37 °C, and the radiochemical purity of each (64)Cu-BFC-Fab-trastuzumab reached 97% after purification. The affinity of each (64)Cu-BFC-Fab-trastuzumab ranged between 10 and 50 nM as evaluated by in vitro saturation assays using
Ethylene cross-bridged cyclam with two acetate pendant arms, ECB-TE2A, is known to form the most kinetically stable 64Cu complexes. However, its usefulness as a bifunctional chelator is limited because of its harsh radiolabeling conditions. Herein, we report new cross-bridged cyclam chelator for the development of ultrastable 64Cu-radiolabeled bioconjugates. Propylene cross-bridged TE2A (PCB-TE2A) was successfully synthesized in an efficient way. The Cu(II) complex of PCB-TE2A exhibited much higher kinetic stability than ECB-TE2A in acid decomplexation studies, and also showed high resistance to reduction-mediated demetalation. Furthermore, the quantitative radiolabeling of PCB-TE2A with 64Cu was achieved under milder conditions compared to ECB-TE2A. Biodistribution studies strongly indicate that the 64Cu complexes of PCB-TE2A cleared out rapidly from the body with minimum decomplexation. © 2012 American Chemical Society. ...
Copper-64 has been shown to dissociate from TETA and TETA-conjugates and to undergo transchelation to superoxide dismutase in rat liver in biodistribution and metabolism studies (7 , 20 , 21 , 27) . The cross-bridged cyclam, CB-TE2A, has demonstrated improved in vitro kinetic stability as well as a reduction of in vivo transchelation (25 , 27 , 38) . These studies suggest that CB-TE2A is an enhanced chelator compared with TETA for labeling 64Cu for in vivo imaging and therapy.. Similar binding affinities for SSTr prepared from AR42J tumor membranes were determined for 64Cu-TETA-Y3-TATE and 64Cu-CB-TE2A-Y3-TATE (Fig. 3)⇓ . However, there was a significant difference in the Bmax values measured for the TETA (192 fmol/mg) and CB-TE2A (1551 fmol/mg) conjugates. This might be attributed to a broader specificity for 64Cu-CB-TE2A-Y3-TATE binding to SSTr than for 64Cu-TETA-Y3-TATE. Although AR42J tumors express SSTr2, these tumor cells have also been shown to express SSTr1, SSTr3, and SSTr5 (31) . ...
Most thought that her fight with Pennington, whom Tate coached on season 18 of The Ultimate Fighter, would see Tate make a statement on her way back to another title shot, perhaps against the winner of Nunes and Rousey. It didnt turn out to be the case.. Tate looked out of sorts and not on her game as a hungry Pennington outworked and pretty much dominated the former champion in every aspect of the fight, on the feet in particular, with an effective jab throughout, in the clinch including a few standing guillotine attempts, one almost ending the fight and on the ground where she was able to neutralize Tates submission attempts.. It was not the Miesha Tate that we all expected to see and the judges scored it 30-27, 30-27 and 29-28 for a unanimous decision in favor of Pennington, who looks to have a bright future in the Womens Bantamweight Division.. Pennington paid tribute to her former TUF coach after the fight To get against Miesha, I love Miesha, shes someone I look up to, she said. ...
Synthesis of [3(5)]Adamanzane, 1,5,9,13-Tetraazabicyclo[7.7.3]nonadecane, by Oxidative C--N Cleavage of [3(6)]Adamanzane, 1,5,9,13-Tetraazatricyclo[7.7.3.3(5,13)]docosane and Crystal Structure of the Tetraprotonated Bromide Salt of [3(5)]Adamanzane.. Springborg, Johan; Pretzmann, Ulla; Nielsen, Bente; Olsen, Carl Erik; S tofte, Inger ...
Voss SD, Smith SV, DiBartolo N, McIntosh LJ, Cyr EM, Bonab AA, Dearling JL, Carter EA, Fischman AJ, Treves ST, Gillies SD, Sargeson AM, Huston JS, Packard AB. Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17489-93 ...
Férédétate de sodium is a medicine available in a number of countries worldwide. A list of US medications equivalent to Férédétate de sodium is available on the Drugs.com website.
At Tate Medical Associates, LLC, we specialize in Family Medicine. Our providers are board certified in Family Medicine and trained in the latest technologies and procedures to ensure optimal outcomes. Our Care Center is conveniently located in Tate, GA.. ...
Seattle Seahawks general manager John Schneider had some interesting things to say about receiver Golden Tate, who did not live up to his potential in his rookie season, finishing with just 21 catches for 227 yards. Schneider said that he has high expectations for the Notre Dame product moving forward, and believes he can develop into a consistent playmaker.. Tate failed to get on the field on a regular basis because of his struggles with route running and picking up the intricacies of a pro-style offense. But during practices last year, he showed the most ability out of any receiver to consistently make plays deep down the field.. I think Golden is a very talented player, Schneider said. I think he recognized that he needs to improve as a route runner, and with his preparation. He was a young guy that never had spring ball, and was just out there just playing on pure ability.. And so for him to come into camp and have all this stuff thrown at him, different route combinations and all that, ...
A series of out of hours events specifically designed for neurodiverse visitors to experience the artist Yayoi Kusama’s work created while she lived in New York, between 1957 and 1973
Make your very own text performance, inspired by text found around you with this Tate Kids activity. Get ideas for your own art and words project or homework activity.
Were glad youve landed here. In our last posts, weve taken you along on our journey towards becoming a more sustainable company, by opening up about our environmental impact, our challenges and…
Get information from Which? Elderly Care about RNIB Tate House including contact details, care specialisms and how to pay for care.
In 2009, barring any miracles from now until August, it looks like the quarterback of this intriguing offense is freshman Tate Forcier, a 4 star recruit from California, who already looks like a major upgrade from 2008. Lets look at his throwing mechanics,
Lyrics to Dark Money by Geoff Tate: Its getting stronger / Cant wait any longer / They woke the beast from sleeping / Now how the
Richard Dorment learnt nothing new from Tate Britains show about art iconoclasm - plus theres pernicious drivel in the catalogue essays.
CU-115 | TLR8 inhibitor | CU115 | CU 115 | CAS [2471982-20-2] | Axon 3155 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
Wilson was harried for much of the day by the multiple looks from the Jets defense. But the Seattle rookie responded with key throws, hitting Tate on the opening drive, then connecting with Rice early in the fourth quarter to give Seattle (6-4) a two-score advantage. Tate added a TD pass on a reverse to Rice later in the fourth quarter ...
Ah, Neil, what a champ. Loved by many, our first metal frame is a real classic, in the purest sense of the word. Youll want to hold on to this one for years to come.
Ah, Neil, what a champ. Loved by many, our first metal frame is a real classic, in the purest sense of the word. Youll want to hold on to this one for years to come.
Köp handgjorda glasögon och solglasögon för män och kvinnor från 1298 kr, inklusive slipade glas. Kostnadsfri leverans och retur. Prova 4 bågar hemma kostnadsfritt.
This collection celebrates the art of lounging. It takes inspiration from the 60s design revolution, which embodied a creative and laid-back state of mind.
New N(4)-methylthiosemicarbazone derivatives: Synthesis, characterization, structural properties, DNA interactions and antiproliferative activity
Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression, radiotherapy resistance, and poor prognosis. One method to detect tumor hypoxia is by positron emission tomography (PET) with the tracer [64Cu][Cu-diacetyl-bis(N(4)-methylthiosemicarbazone)] ([64Cu][Cu(ATSM)]), as demonstrated in both preclinical and clinical studies. In addition, emerging studies suggest using [64Cu][Cu(ATSM)] for molecular radiotherapy, mainly due to the release of therapeutic Auger electrons from copper-64, making [64Cu][Cu(ATSM)] a
TY - JOUR. T1 - Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals. AU - Maurer, Richard I.. AU - Blower, Philip J.. AU - Dilworth, Jonathan R.. AU - Reynolds, Christopher A.. AU - Zheng, Yifan. AU - Mullen, Gregory E.D.. PY - 2002/3/1. Y1 - 2002/3/1. N2 - Copper diacetyl-bis(N4-methylthiosemicarbazone), Cu(II)ATSM, is a promising agent for imaging hypoxic tissue. Here we present results that provide insight into the chemical and electronic properties underlying previously observed structure-activity relationships. Density functional theory (DFT) calculations on the electronic structures and molecular orbitals of a series of 13 Cu(II)bis(thiosemicarbazone) analogues with different alkylation patterns and with fixed geometries based on the known structure of Cu(II)PTSM showed that the LUMO and the next lowest orbital were very close in energy, and their energy order was strikingly dependent on the ligand alkylation pattern in a way that ...
From the It-Doesnt-Take-Much-to-Believe-This Dept., Seattle Seahawks wide receiver Golden Tate was allegedly drunk Saturday morning when he found himself offside in a Top Pot donut shop.. That is what the female employee who called 911 said, according to TMZ.com, which received a copy of the emergency call to police. The Top Pot worker said Tate was drunk and being retarded when he entered through an unlocked door and stole maple bars at 3 a.m.. Tate and a friend allegedly took keys to the place and a bunch of donuts before running off. Tate allegedly then returned to the scene of the crime and returned the keys. He reportedly tried to blame his friend but the employee saw Tate running from behind the counter.. Police issued Tate a trespass warning, which is a half-step above receiving a pinky promise from him that it will not happen again. On Tuesday afternoon, Tate fingered his accomplice in the maple bar spree and apologized. Sort of ...
In this study, tumor sub-volumes were defined based on a DPBC strategy of FDG and 64Cu-ATSM PET, and the overlap between these sub-volumes was analyzed.. Two cut-off values for FDG uptake were explored, and 64Cu-ATSM uptake was analyzed by sub-volumes based on two different time-points for image acquisition. We observed an overlap between all 64Cu-ATSM and FDG sub-volumes. However, the degree of overlap varied between cases.. Our results showed that a fairly large part of the hypoxic sub-volume as defined by 64Cu-ATSM was not included in a boost volume based on FDG uptake with the chosen thresholds. However, the hypoxic sub-volume did not encompass the FDG uptake either, and it therefore seems attractive to include both tracers in RT planning considering their association to treatment outcome and prognosis.. The Cu24 sub-volume was predominantly included in the BTV consisting of FDG (FDG40 or FDG50) and Cu3. This result suggests that the temporal variations of 64Cu-ATSM uptake might be taken ...
Tate & Lyle has anoounced that it is in the final stages of discussions with Syral SAS on the disposal of certain businesses including the starch business. A full copy of the anouncement is below:. Tate & Lyle announces that it is at an advanced stage of exclusive discussions with Syral SAS (a subsidiary of Tereos of France) which may lead to the disposal of its interest in certain of the facilities of its Food & Industrial Ingredients, Europe division (TALFIIE), and that it has today begun the consultation process with the European and local works councils and other employee representatives.. Tate & Lyle announced on 25 October 2006 that it was exploring the possibility of the full or partial disposal of TALFIIE. The TALFIIE operations that are subject to the ongoing discussions (the Target Businesses) announced today are those in the UK, Belgium, France, Spain and Italy.. Tate & Lyles operations in Koog, The Netherlands (the main site in Western Europe for corn-based value added starch ...
The first of many Negro League franchises to try and fail in Cleveland, OH was the Cleveland Tate Stars (named after owner George Tate). They played in the Negro National League in 1922 and finished last at 17-29. Candy Jim Taylor managed and played third base for the club. Following a dispute between team owner Tate and NNL president Rube Foster and Tates sacking of manager Taylor, the Tate Stars played the first part of the 1923 season as an associate team of the Eastern Colored League during the first part of the 1923 season. They were opposed in Cleveland by the short-lived Cleveland Nationals, and some of their players were raided by NNL teams, but they rejoined the NNL as an associate team in July following the demise of the Toledo franchise, and went 7-14. Second baseman Claude Hooks Johnson was the player-manager. In 1924 they were replaced in the city by the Cleveland Browns. Sources: ...
TY - JOUR. T1 - Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy. AU - Li, Xia. AU - Shenashen, Mohamed A.. AU - Wang, Xiupeng. AU - Ito, Atsuo. AU - Taniguchi, Akiyoshi. AU - Ei-Safty, Sherif A.. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we fabricated hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands (Cu- and Zn-AMSs) with randomly wrinkled morphology, mesoscale void- or cave-like pockets, high-exposed surface coverage sites, and positive charge streams in saline. We confirmed that Cu- and Zn-AMSs promoted intracellular uptake of model cancer antigen (ovalbumin, OVA) by THP-1-differentiated macrophage-like cells in vitro. Moreover, Cu- and ...
OUTLINE: This is a multicenter study.. Patients receive copper Cu 64-ATSM IV and undergo PET/CT scan over 30 minutes 30-40 minutes later. Within 4 weeks after copper Cu 64-ATSM-PET/CT scan, patients begin planned concurrent standard of care chemoradiotherapy comprising 6 weeks of radiotherapy (external beam and brachytherapy)and weekly cisplatin administration per NCCN guidelines. Patients then undergo FDG-PET/CT scan 3 months after completion of chemoradiotherapy.. Tissue samples from previously collected cervical biopsy (obtained for diagnosis) are used for detecting hypoxic markers by immunohistochemistry analysis.. After completion of study intervention, patients are followed for every 3 months for 2 years and then every 6 months for 1 year. ...
A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic
I love meringues. Ive heard its easy so make. Ive seen the chefs make them on tele so effortlessly but Ive never tried making them before. It was one of my baking dreams to make them (and cookies, isnt that one of the things that mums do?). Now that we have a larger kitchen in our new home, I jumped at the chance to give it a try them when opportunity came to me. Im not good with baked treats but nothing like a blog opportunity to get me going. I accepted some Tate & Lyle golden Mayan inspired caster sugar to make meringue letters. Yeah, I like a challenge not even meringue dollops but I had to make words. I knew I was off to a bad start when I kept getting the yoke in with the whites! I persisted; in the end I ended up with something that looking a bit wonky but meringues nonetheless. The Tate & Lyle golden caste sugar give my meringues a lovely sort of rosy colour.. The Trial. Heres how my trials went, and dont laugh too hard at my meringues. It was my first time.. Trial 1: It went ...
Looking For Tate Schmitt stats ? Get detailed information about their nationality, club details, skills, stats and key traits below -. Tate Schmitt Profile -. ...
This Saturday, Miesha Tate puts her Strikeforce bantamweight title on the line against sassy armbar-savant Ronda Rousey, in the first major MMA event to be headlined by two women since Carano vs. Cyborg. Will Tates experience and wrestling win the day, or will Rowdy Ronda continue her phenomenal rise? Check out these stunning promo photos from our buddies at Showtime and let us know what you think in the comments section. And dont forget to come back to CagePotato.com on Saturday night starting at 10 p.m. ET to join our liveblog of the Strikeforce: Tate vs. Rousey main card broadcast on Showtime!. ...
Dr. Melita Tate, MD is a Internal Medicine Specialist in Tulsa, OK. She is accepting new patients. Be sure to call ahead with Dr. Tate to book an appointment.
Get used to it, Denard?. Ill try to figure out some more stuff after the replay at 8 but for now, things I noticed. They are mostly about offensive skill position players, because Im a person.. Denard! Denard! Denard! Disclaimer: It was all ones versus twos and whatnot, so Denard took the starting offense against a motley collection of walk-ons and Tate took a bunch of freshmen up against the first team defense. The playing field was far from level. That said, holy crap. Robinson looks like a quarterback now. A running quarterback with rudimentary passing abilities, but a quarterback. There were zone reads and screens and rollout passes and a number of zippy seams that hit players between the numbers. When the offense broke down, Robinson made the concept of pursuit angles humorous. Putting him on the edge, as suggested by the coaches clinic tea leaves, puts the defense in a bind. His throws were all on a line but they were accurate aside from a couple mediocre bubble screens. There were ...
Herzog & de Meuron set about designing the Tate Modern Extension in 2006 with a modern, glass-filled aesthetic that contrasted the museum buildings origins as
Detailed profile of Beverly Tate, MS-EDS, NCC, LPCA, a Counselor - Mental Health Greensboro NC. See insurances she accepts. Read ratings and reviews from other patients.
Last week I (finally) discovered the oh so anticipated new building of the Tate Modern, which opened to the public on June 17. Under the slogan Art Changes We Change, the museum managed its transformation very successfully and convinced the skeptics of the need for an extension in order to reach this ideal of an ultimate…
Tate & Lyle announces that it has entered into a pre-financing agreement with the Jamaican government for the supply of raw sugar. The agreement requires the supply of 100,000 tonnes of raw sugar to...
Artist Anne Hardy has created apocalyptic Christmas lights for Tate Britains annual winter commission, to raise awareness of climate change.
Explore the Panasonic CU-3S27KKZ Aero Series - Multi Split - Panasonic AERO Series The AERO SLIM design features sleek lines and graceful curves while the lustrous pearl finishing and chrome escutcheon exude a sense of luxury.
Sanken microphones, Japans first and most original microphone company, has introduced the new CU-51 cardioid condenser microphone as part of the Sanken Chromatic range of professional studio mics.
Magazin online Primadrogherie.ro. Cumpără online Q-absorb (CoQ-10 100mg) (30 capsule), Jarrow Formulas la cel mai bun preț. Află promoția noastră. Dorești consiliere telefonică? Îți răspundem cu drag la 0732.258.382
Lucrăm în parteneriat cu Institutul Național de Sănătate Publică. Pentru col uterin, populația care trebuie să fie cancer du col uterin oncologik este din grupa de vârstă de ani, iar în cazul screeningului HPV, populația feminină cu vârsta între 30 și 64 de ani. Politicile de sănătate promovate de Guvern pun accent pe depistarea și tratarea unor boli cu morbiditate și mortalitate mare, care au costuri mari de îngrijre și ale caror șanse de vindecare sunt mult mai mari, dacă sunt depistate la timp.
Tento dokument informuje používateľov distribúcie Debian o hlavných zmenách vo verzii 9 (kódové označenie „stretch). Poznámky k vydaniu poskytujú informácie o tom ako bezpečne aktualizovať systém z predošlého vydania 8 (kódové označenie jessie) na aktuálne vydanie a informujú používateľov o známych potenciálnych problémoch, s ktorými by sa mohli stretnúť počas aktualizácie. Najnovšia verzia tohto dokumentu je vždy dostupná na https://www.debian.org/releases/stretch/releasenotes. Ak si nie ste istý či čítate aktuálnu verziu, skontrolujte dátum na prvej stránke a uistite sa, že čítate aktuálnu verziu. ...
The NBC and CBS late-night shows will be in re-runs this coming week, but ABCs Jimmy Kimmel Live will air four new episodes. Each will feature a
Im over Harvin already. I was just as excited as everyone when Seattle got him, but Hurtvin is costing this team potential players. When it comes time to sign some other big name players - one that actually contributed to this great campaign, and Im looking at RW, Sherman, and ET, there are gonna be holes left by their departure because of the cost of bringing Percy on board. Im tired of getting excited to see him play. He probably re-aggravated his hip trying to play against his old team that got rid of him - and who knows when well see him again. Dude is a hell of a ballplayer, but hes made of glass inside out. Im happy with Tate, Baldwin, and Kearse as our wide receivers, theyre cheap, and can be very reliable when called upon. Tate is a young star, and hes going to be playing for someone else next season. When theres so little to gamble, this front office is awesome with their late round picks. When they hemorrhage high picks on players that dont pan out (Hi, James Carpenter, and ...
If you wish to pay via Electronic Funds Transfer, please define a reference below to be used during the funds transfer. Keep the value entered to a combination of numbers and letters. Upon submission, you will receive an email with payment instructions which will include the value to be transferred, our bank details, and your reference number for payment ...
Its spring. The sun is out. The clocks have changed. And so have I. I left my old job three weeks ago. It was time for change, and so for a few weeks my times my own. My days are brighter now, and I feel refreshed, revitalised and renewed. The sun shone all the way…
Its spring. The sun is out. The clocks have changed. And so have I. I left my old job three weeks ago. It was time for change, and so for a few weeks my times my own. My days are brighter now, and I feel refreshed, revitalised and renewed. The sun shone all the way…
EU SINCER KA SIMPLA CETATEANA A ACESTEI TARI, AS VREA SA STIU CINE I PE PRIMU LOC ANTENA 3 CAND SPUNE SEARA CA ANTENA 3 ESTE PE PRIMUL LOC LA AUDIENTA TELESPECTATORIILOR, SAU RTV CARE SPUNE LA ACEIASI ORA, IN ACEIASI ZI, KA RTV ESTE PE PRIMUL LOC LA AUDIENTA…DECI.,!?!?….CRED KA NICIUNA NU MAI ESTE PE PRIMU LOC DEEEEE MUUULT..DAR DC SA NU DEZINFORMAM PUTIN..KA DA BINE LA FIRMELE CARE VOR SA SI FACA PUB LA EI…….SI ATUNCI NOI PE CINE CREDEM FRATE??!?. ...
EU SINCER KA SIMPLA CETATEANA A ACESTEI TARI, AS VREA SA STIU CINE I PE PRIMU LOC ANTENA 3 CAND SPUNE SEARA CA ANTENA 3 ESTE PE PRIMUL LOC LA AUDIENTA TELESPECTATORIILOR, SAU RTV CARE SPUNE LA ACEIASI ORA, IN ACEIASI ZI, KA RTV ESTE PE PRIMUL LOC LA AUDIENTA…DECI.,!?!?….CRED KA NICIUNA NU MAI ESTE PE PRIMU LOC DEEEEE MUUULT..DAR DC SA NU DEZINFORMAM PUTIN..KA DA BINE LA FIRMELE CARE VOR SA SI FACA PUB LA EI…….SI ATUNCI NOI PE CINE CREDEM FRATE??!?. ...
The Small-Animal Imaging Facility is committed to supporting the Institutes cutting-edge research with state-of-the-art imaging capabilities and expertise.
Tate Gisslen, Manuel Alvarez, Casey Wells, Man-Ting Soo, Donna S Lambers, Christine L Knox, Jareen K Meinzen-Derr, Claire A Chougnet, Alan H Jobe, Suhas G Kallapur ...
There isn ??t much chitchat between Will Helm and Tate Ryder: these two young and hot guys are much more skilled with their body language, which is wh
Tate Fegley may stand at just 4 feet, 7 inches tall and weigh 103 pounds, but hes already proving to be a force to be reckoned with in the powerlifting world.
Утром 27 августа разработчики выпустили патч 7.27d для Dota 2. Изменения коснулись некоторых предметов и ряда героев, в том чи...
Cu 200 found in: Manufacturer/Model By Series Fishing Reel Bearings, SHIMANO CURADO CU-200 BANTAM BAITCASTER Manufacturer/Model By Series Fishing Reel..
The list cites air pollution by particulates, including radioisotopes strontium-90, and caesium-137; the metals nickel, copper ... 2 copper and nickel smelters (in the so-called Nadezhda complex), which led to bringing substantial numbers of Finnish ... The nickel deposits of Norilsk-Talnakh are the largest-known nickel-copper-palladium deposits in the world. The smelting of the ... Norilsk is the center of a region where nickel, copper, cobalt, platinum, palladium and coal are mined. Mineral deposits in the ...
Chelators for Copper Radioisotopes with Fast Complexation". Inorganic Chemistry. 59 (12): 8432-8443. doi:10.1021/acs.inorgchem. ...
The particle usually comes from the radioactive decay of an atom of a radioisotope, an isotope of an element which is ... Beginning in 1908, luminous paint containing a mixture of radium and copper-doped zinc sulfide was used to paint watch faces ... Radium was used in luminous paint until the 1960s, when it was replaced with the other radioisotopes above due to health ... Phosphors containing silver-doped zinc sulfide (ZnS:Cu) yield blue-green light; copper and manganese-doped zinc sulfide (ZnS:Cu ...
Dearling, Jason L.; Lewis, Jason S.; Mullen, Gregory E.; Welch, Michael J.; Blower, Philip J. (20 April 2014). "Copper bis( ... They have also been identified as potential ligands for radioisotope delivery, with selectivity towards hypoxic tissues, ... "In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes". Journal of Medicinal Chemistry. 56 (3): ... "Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals". Journal of Medicinal ...
The zinc core is coated with a thin layer of copper to give the appearance of a copper coin. In 1994, 33,200 tonnes (36,600 ... 65 Zn, which has a half-life of 243.66 days, is the least active radioisotope, followed by 72 Zn with a half-life of 46.5 hours ... n 30Zn + e− → n 29Cu The most common decay mode of a radioisotope of zinc with mass number higher than 66 is beta decay (β−), ... Zinc ores were used to make the zinc-copper alloy brass thousands of years prior to the discovery of zinc as a separate element ...
Copper: Copper anemia in infants results from infants with a poor diet and can cause heart disease. Metal ions are often used ... 99mTc is the most commonly used radioisotope agent for imaging purposes. It has a short half-life, emits only gamma ray photons ... Gold, Silver, Copper: Phosphine ligand compounds containing gold, silver, and copper have anti-cancer properties. Lanthanum: ... Examples of specific types of toxic metals include: Copper: copper toxicity usually presents itself as a side effect of low ...
Mixing about 2.0% beryllium into copper forms an alloy called beryllium copper that is six times stronger than copper alone. ... natural beryllium bombarded either by alphas or gammas from a suitable radioisotope is a key component of most radioisotope- ... When added as an alloying element to aluminium, copper (notably the alloy beryllium copper), iron or nickel beryllium improves ... Beryllium-copper alloys were also applied as a hardening agent in "Jason pistols", which were used to strip the paint from the ...
Twenty-two radioisotopes have been characterized: the most stable, 60Co, has a half-life of 5.2714 years; 57Co has a half-life ... Blue glass from Egypt was either colored with copper, iron, or cobalt. The oldest cobalt-colored glass is from the eighteenth ... Cobalt-57 (Co-57 or 57Co) is a cobalt radioisotope most often used in medical tests, as a radiolabel for vitamin B12 uptake, ... Subsequent roasting converts the ores to cobalt sulfate, and the copper and the iron are oxidized to the oxide. Leaching with ...
His basic method is still used today: electricity is generated by the movement of a loop of wire, or disc of copper between the ... team Reactor protection system Nuclear safety in the United States Nuclear power in space Advanced Stirling Radioisotope ... Nuclear fission Nuclear physics Atomic nucleus Ionizing radiation Nuclear fission Radiation Radioactivity Radioisotope ...
... radioisotopes are used in some radioisotope thermoelectric generators. Iridium is found in meteorites in much higher ... During electrorefining of copper and nickel, noble metals such as silver, gold and the platinum group metals as well as ... The radioisotope iridium-192 is one of the two most important sources of energy for use in industrial γ-radiography for non- ... At least 37 radioisotopes have also been synthesized, ranging in mass number from 164 to 202. 192Ir, which falls between the ...
Copper (29Cu) has two stable isotopes, 63Cu and 65Cu, along with 27 radioisotopes. The most stable radioisotope is 67Cu with a ... ISBN 978-0-8493-0485-9. Application of Copper radioisotopes in Medicine (Review Paper): Pejman Rowshanfarzad; Mahsheed Sabet; ... Copper offers a relatively large number of radioisotopes that are potentially suitable for use in nuclear medicine. There is a ... Unstable copper isotopes with atomic masses below 63 tend to undergo β+ decay, while isotopes with atomic masses above 65 tend ...
Qureshi engaged in research about copper-nickel alloys after introducing the lattice dynamical method to evaluate the Cu29/Ni28 ... Electrochemical Analysis lab and radioisotope production labs. The Analytical Chemistry Laboratory was later certified by the ...
The radioisotope iodine-131, which has a high fission product yield, concentrates in the thyroid, and is one of the most ... The firstalloy, used in large scale since 3000 BC, was bronze, an alloy of tin and copper. After 600 BC pure metallic tin was ... Most silver is produced as a byproduct of copper, gold, lead, and zinc refining. Silver has long been valued as a precious ... Pewter, which is an alloy of 85-90% tin with the remainder commonly consisting of copper, antimony and lead, was used for ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Zn, which has a half-life of 243.66 days, is the least active radioisotope, followed by 72. Zn with a half-life of 46.5 hours.[ ... The zinc core is coated with a thin layer of copper to give the appearance of a copper coin. In 1994, 33,200 tonnes (36,600 ... 442-501 in Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, ...
Copper in solders forms intermetallic compounds. Supersaturated (by about 1%) solution of copper in tin may be employed to ... Radioisotopes undergoing alpha decay are a concern due to their tendency to cause soft errors. Polonium-210 is especially ... Tin-silver-copper (Sn-Ag-Cu, or SAC) solders are used by two-thirds of Japanese manufacturers for reflow and wave soldering, ... Alloys of copper with either zinc or silver are the most common. In silversmithing or jewelry making, special hard solders are ...
In 1920-1921, George de Hevesy measured self-diffusion using radioisotopes. He studied self-diffusion of radioactive isotopes ... Robert Boyle demonstrated diffusion in solids in the 17th century by penetration of zinc into a copper coin. Nevertheless, ...
... chromium radioisotopes MeSH D01.496.749.256 - cobalt radioisotopes MeSH D01.496.749.270 - copper radioisotopes MeSH D01.496. ... iron radioisotopes MeSH D01.496.749.540 - krypton radioisotopes MeSH D01.496.749.560 - lead radioisotopes MeSH D01.496.749.590 ... xenon radioisotopes MeSH D01.496.749.960 - yttrium radioisotopes MeSH D01.496.749.980 - zinc radioisotopes MeSH D01.496.807.800 ... xenon radioisotopes MeSH D01.496.943.800 - yttrium radioisotopes MeSH D01.496.966.800 - zinc radioisotopes MeSH D01.524.500.040 ...
"5 Year Copper Prices and Copper Price Charts - InvestmentMine". InfoMine. Retrieved 2 May 2015. "Copper Theft Threatens U.S. ... TV screens and in radio isotopes. Demand for these metals appeared to be increasing as computers and mobile phones became more ... "Copper prices London". Retrieved 3 July 2010. "Historical Copper Prices, Copper Prices History". Dow-futures.net. 22 January ... It was also noticed that a copper price bubble was occurring at the same time as the oil bubble. Copper traded at about $2,500 ...
ISBN 978-1-4757-6918-0. Copper Development Association. "Leaded Coppers". copper.org. Retrieved 10 July 2016. Cotnoir, B. (2006 ... Lead-205 is the most stable radioisotope, with a half-life of around 1.73×107 years. The second-most stable is lead-202, which ... Copper alloys with larger concentrations of lead are used in bearings. The lead provides lubrication, and the copper provides ... Lead's tensile strength, at 12-17 MPa, is low (that of aluminium is 6 times higher, copper 10 times, and mild steel 15 times ...
Tellurium is added to copper (Tellurium Copper) and steel alloys to improve their machinability; and to lead to make it harder ... heavy metals are also employed as spallation targets for the production of neutrons or radioisotopes such as astatine (using ... Copper and lead are therefore used, for example, as roofing materials; zinc acts as an anti-corrosion agent in galvanised steel ... Copper, zinc, silver, gold, or mercury are used in antiseptic formulations; small amounts of some heavy metals are used to ...
While radioisotopes had been used in human nutrition research for several decades prior, stable isotopes presented a safer ... Iron, zinc, calcium, copper, magnesium, selenium and molybdenum are among the essential minerals having stable isotopes to ... In soil science 15N tracers are used extensively to study nitrogen cycling, whereas 13C and 14C, stable and radioisotopes of ... Other advantages offered by stable isotopes include the ability to study elements having no suitable radioisotopes and to study ...
These are chemical compounds in which one or more atoms have been replaced by a short-lived, positron emitting radioisotope. [ ... 11C] Martinostat [18F] Fludeoxyglucose (18F) (FDG)-glucose analogue [11C] Acetate [11C] Methionine [11C] choline Copper 64Cu ...
Commercially, the primary use of tellurium is copper (tellurium copper) and steel alloys, where it improves machinability. ... A further 31 artificial radioisotopes of tellurium are known, with atomic masses ranging from 104 to 142 and with half-lives of ... The principal source of tellurium is from anode sludges from the electrolytic refining of blister copper. It is a component of ... The addition to steel and copper produces an alloy more machinable than otherwise. It is alloyed into cast iron for promoting ...
At least 27 radioisotopes have also been synthesized, ranging in atomic mass from 58 to 89. The most stable of these is 68 Ge ... Some zinc-copper-lead ore bodies contain enough germanium to justify extraction from the final ore concentrate. An unusual ... While it is produced mainly from sphalerite, it is also found in silver, lead, and copper ores. Another source of germanium is ... While most of germanium's radioisotopes decay by beta decay, 61 Ge and 64 Ge decay by β+ delayed proton emission. 84 Ge through ...
Iridium radioisotopes are used in some radioisotope thermoelectric generators. Iridium is found in meteorites with an abundance ... It occurs in some nickel and copper ores along with some native deposits, mostly in South Africa, which accounts for 80% of the ... Although the element is only mildly toxic, it is a hazardous material as a metal and its radioisotopes present a high health ... Tungsten interferes with molybdenum and copper metabolism, and is somewhat toxic to animal life. Rhenium is a chemical element ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... While most of germanium's radioisotopes decay by beta decay, 61. Ge. and 64. Ge. decay by β+. delayed proton emission.[46] 84. ... At least 27 radioisotopes have also been synthesized, ranging in atomic mass from 58 to 89. The most stable of these is 68. Ge ... While it is produced mainly from sphalerite, it is also found in silver, lead, and copper ores. Another source of germanium is ...
Most of the remaining radioisotopes have half-lives that are less than a day. 199 Hg and 201 Hg are the most often studied NMR- ... Several other first row transition metals with the exception of manganese, copper and zinc are also resistant in forming ... There are seven stable isotopes of mercury, with 202 Hg being the most abundant (29.86%). The longest-lived radioisotopes are ... 47 Several other countries are believed to have unrecorded production of mercury from copper electrowinning processes and by ...
Type T (copper-constantan) thermocouples are suited for measurements in the −200 to 350 °C range. Often used as a differential ... In a radioisotope thermoelectric generator, the radioactive decay of transuranic elements as a heat source has been used to ... Type-T thermocouples have a sensitivity of about 43 µV/°C. Note that copper has a much higher thermal conductivity than the ... For such cases, a number of thermocouple leads will be brought to a common reference block (a large block of copper) containing ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Twenty-eight radioisotopes have been characterized, the most stable being 105Ag with a half-life of 41.29 days, 111Ag with a ... The precipitation of copper in ancient silver can be used to date artifacts, as copper is nearly always a constituent of silver ... The principal sources of silver are the ores of copper, copper-nickel, lead, and lead-zinc obtained from Peru, Bolivia, Mexico ...
The most stable radioisotopes are 101Rh with a half-life of 3.3 years, 102Rh with a half-life of 207 days, 102mRh with a half- ... In 2007, rhodium cost approximately eight times more than gold, 450 times more than silver, and 27,250 times more than copper ... Twenty other radioisotopes have been characterized with atomic weights ranging from 92.926 u (93Rh) to 116.925 u (117Rh). Most ... including the copper-nickel sulfide mining area of the Sudbury, Ontario, region. Although the rhodium abundance at Sudbury is ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Radioisotopes of caesium require special precautions: the improper handling of caesium-137 gamma ray sources can lead to ... In this 1871 version, copper, silver, and gold were placed twice, once as part of group IB, and once as part of a "group VIII" ... All of the alkali metals except lithium and caesium have at least one naturally occurring radioisotope: sodium-22 and sodium-24 ...
lithium-copper oxide). Li-CuO. Li. CuO. 1.7. No longer manufactured.. Replaced by silver oxide (IEC-type "SR") batteries.. ... It consisted of a copper pot filled with a copper sulfate solution, in which was immersed an unglazed earthenware container ... This was a stack of copper and zinc plates, separated by brine-soaked paper disks, that could produce a steady current for a ... Radioisotope thermoelectric generator. *Solar power *Photovoltaic system. *Concentrated solar power. *Solar thermal energy * ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... 27 radioisotopes have been observed, with the most stable ones being 169Yb with a half-life of 32.0 days, 175Yb with a half- ...
Copper 9000 BC 6000 BC Middle East Anatolia Copper was probably the first metal mined and crafted by humans.[1] It was ... Marinsky, J. A.; Glendenin, L. E.; Coryell, C. D. (1947). "The chemical identification of radioisotopes of neodymium and of ... CSA - Discovery Guides, A Brief History of Copper *^ "Serbian site may have hosted first copper makers". UCL.ac.uk. UCL ... Found by attempting to extract copper from the mineral known as fake copper (now known as niccolite).[37] ...
... radioisotope Radium Radon Radon fluoride Raman spectroscopy Raoult's law Redox Reduction Reflux Reversible reaction Rhazes ... Weights complex compound computational chemistry Concentration condensation polymer Condensation reaction Cooperite Copper ... Svante Arrhenius Syenite Sylvite synthetic radioisotope systematic element name Tabun Talc Talcum Tantalite Tantalum Tanzanite ...
... by way of a process which is known as phytoremediation-the process of clearing radioisotopes and a variety of other toxins from ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Fourteen radioisotopes have been characterized. The most stable are 15O with a half-life of 122.24 seconds and 14O with a half- ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Fourteen radioisotopes have been characterized. The most stable are 15O with a half-life of 122.24 seconds and 14O with a half- ...
injection of medical radioisotopes such as technetium-99m. The occupational hazards from airborne radioactive particles in ... Recent studies show that copper shielding is far more effective than lead and is likely to replace it as the standard material ... Hand-held ion chamber survey meter in use for surface dose rate on one of three radioisotope thermoelectric generators (RTGs) ... and copper, usually ending with aluminium. Sometimes even lighter materials such as polypropylene or boron carbide are used.[17 ...
It was not until Thomson convinced the board that using purer copper for replacing the lost section of cable would improve data ... "Natürliche Radioisotope: die "Atomuhr" für die Bestimmung des absoluten Alters von Gesteinen und archäologischen Funden". ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Thirty radioisotopes have been characterised, which range in mass number from 209[22] to 238.[20] After 232Th, the most stable ... In 1815, the Swedish chemist Jöns Jacob Berzelius analysed an unusual sample of gadolinite from a copper mine in Falun, central ... copper's 137.8 GPa; and mild steel's is 160-169 GPa.[5] Thorium is about as hard as soft steel, so when heated it can be rolled ...
... in which he converted the mechanical energy of a rotating copper disc to electrical energy.[61] Faraday's disc was inefficient ... made from alternating layers of zinc and copper, provided scientists with a more reliable source of electrical energy than the ... Radioisotope thermoelectric generator. *Solar power *Photovoltaic system. *Concentrated solar power. *Solar thermal energy * ...
Metals melted include iron and steel, copper, aluminium, and precious metals. Because it is a clean and non-contact process it ... Component of Stirling radioisotope generator is heated by induction during testing. Induction heating is the process of heating ... Copper-bottomed pans, aluminum pans and other non-ferrous pans are generally unsuitable. The heat induced in the base is ... The induction coil is usually made of copper tubing and fluid cooled. Diameter, shape, and number of turns influence the ...
The copper cables (transmission lines) which are used to carry lower frequency radio waves to antennas have excessive power ... Gamma rays are used experimentally by physicists for their penetrating ability and are produced by a number of radioisotopes. ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... 19 radioisotopes have been characterized, with the most stable being 50Cr with a half-life of (more than) 1.8×1017 years, and ... This occurs again later in the periodic table with other elements and their electron configurations, such as copper, niobium, ... For example, chromated copper arsenate (CCA) is used in timber treatment to protect wood from decay fungi, wood-attacking ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... 204Tl is the most stable radioisotope, with a half-life of 3.78 years.[12] It is made by the neutron activation of stable ... The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small, nontoxic amounts as an agent in a nuclear ... The major source of thallium for practical purposes is the trace amount that is found in copper, lead, zinc, and other heavy- ...
A TPV radioisotope converter with 20% efficiency was demonstrated that uses a tungsten emitter heated to 1350 K, with tandem ... Copper indium gallium selenide solar cells. *Printed solar panel. *Perovskite solar cell ... NASA Radioisotope Power Conversion Technology NRA Overview. *New thermophotovoltaic materials could replace alternators in cars ... As a result, solar and radioisotope fuels (extremely high power density and long lifetime) are ideal sources of energy. TPVs ...
Unlike other metals such as gold, silver, copper or nickel, uranium is not widely traded on an organized commodity exchange ... uranium and thorium radioisotopes naturally found in coal and concentrated in heavy/bottom coal ash and airborne fly ash.[103] ... when that mine is predominantly a copper mine and uranium is produced only as a co-product, along with gold and other metals.[ ...
His basic method is still used today: electric current is generated by the movement of a loop of wire, or disc of copper ... Radioisotope thermoelectric generator. *Solar power *Photovoltaic system. *Concentrated solar power. *Solar thermal energy * ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... is also sometimes considered as a light radioisotope of hydrogen, due to the mass difference between the antimuon and the ... copper-chlorine cycle and hybrid sulfur cycle are under research and in testing phase to produce hydrogen and oxygen from water ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... The longest-lived radioisotopes are thulium-171, which has a half-life of 1.92 years, and thulium-170, which has a half-life of ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... allowing the use of radioisotope rubidium-82 in nuclear medicine to locate and image brain tumors.[50] Rubidium-82 has a very ... and rubidium copper sulfate, Rb2SO4·CuSO4·6H2O. Rubidium silver iodide (RbAg4I5) has the highest room temperature conductivity ... roughly as abundant as zinc and rather more common than copper.[19] It occurs naturally in the minerals leucite, pollucite, ...
In crystallography, a copper target is most common, with cobalt often being used when fluorescence from iron content in the ...
Copper. Zinc. Gallium. Germanium. Arsenic. Selenium. Bromine. Krypton. Rubidium. Strontium. Yttrium. Zirconium. Niobium. ... The most stable radioisotopes are 107Pd with a half-life of 6.5 million years (found in nature), 103Pd with 17 days, and 100Pd ... Eighteen other radioisotopes have been characterized with atomic weights ranging from 90.94948(64) u (91Pd) to 122.93426(64) u ... The most important commercial sources are nickel-copper deposits found in the Sudbury Basin, Ontario, and the Norilsk-Talnakh ...
The repository concept is similar to the Swedish model, with containers to be clad in copper and buried below the water table ... Multi-Mission Radioisotope Thermoelectric Generator. *Accidents and incidents. *Policy. *Fusion. *Radioisotope thermoelectric ( ... Conceptual design of a permanent repository was determined by 1983, calling for placement of copper-clad iron canisters in ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... At least 26 nickel radioisotopes have been characterised, the most stable being 59. Ni with a half-life of 76,000 years, 63. Ni ... for besetting the copper. They called this ore Kupfernickel from the German Kupfer for copper.[48][49][50][51] This ore is now ... "white copper" (cupronickel, known as baitong) was used there between 1700 and 1400 BCE. This Paktong white copper was exported ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... Hg being the most abundant (29.86%). The longest-lived radioisotopes are 194. Hg with a half-life of 444 years, and 203. Hg ... Most of the remaining radioisotopes have half-lives that are less than a day. 199. Hg and 201. Hg are the most often studied ... Several other first row transition metals with the exception of manganese, copper and zinc are reluctant to form amalgams. ...
Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum ... The most stable chlorine radioisotope is 36Cl. The primary decay mode of isotopes lighter than 35Cl is electron capture to ... As introduced by Deacon, early catalysts were based on copper. Commercial processes, such as the Mitsui MT-Chlorine Process, ...
... Artor Niccoli Asabella,1 Giuseppe Lucio Cascini,2 ... F. Szelecsényi, G. F. Steyn, K. Suzuki et al., "Application of Zn+p reactions for production of copper radioisotopes for ... A. Niccoli Asabella, G. L. Cascini, C. Altini, D. Paparella, A. Notaristefano, and G. Rubini, "The copper radioisotopes: a ... D. W. McCarthy, L. A. Bass, P. D. Cutler et al., "High purity production and potential applications of copper-60 and copper-61 ...
"Copper Radioisotopes" by people in this website by year, and whether "Copper Radioisotopes" was a major or minor topic of these ... "Copper Radioisotopes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Copper Radioisotopes" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Copper Radioisotopes". ...
... relates to an universal method for the large scale production of high-purity carrier free or non carrier added radioisotopes by ... Since there are no other long-lived zinc isotopes decaying to radioactive copper isotopes, such a generator can even be ... The radioisotopes produced by the method of the present invention are preferably used for producing radioisotope-labelled ... The radioisotopes produced by the inventive method are especially suitable for producing radioisotope-labelled bioconjugates as ...
Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging ... Click chemistry (copper-catalyzed azide-alkyne cycloaddition). PET/MRI. Macrophage detection in aortic aneurysms. [45]. ... Click chemistry (copper-catalyzed azide-alkyne cycloaddition). PET/MRI. Biodistribution studies. [43]. ... Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging. Table 1. ...
Tens of millions of nuclear medicine procedures are performed each year, and demand for radioisotopes is increasing rapidly ... the use of radioisotopes for diagnostics, radiation therapy, radiopharmaceuticals and other beneficial medical uses of nuclear ... Copper-64 (13 h):. Used to study genetic diseases affecting copper metabolism, such as Wilsons and Menkes diseases, for PET ... The global radioisotope market was valued at $9.6 billion in 2016, with medical radioisotopes accounting for about 80% of this ...
... copper, molybdenum; The other transition metals and zinc; The metalloids: arsenic, antimony, selenium, tellurium and boron; The ... new metal contaminants; The radioactive metals; Radioisotopes; The catalytic metals; The electronic metals; Germanium; Tantalum ...
New Radioisotope for Cancer Therapy: A new Collaboration to produce copper-67. Aug 25, 2021 ... New Radioisotope for Cancer Therapy: A new Collaboration to produce copper-67 August 25, 2021 ... CIIC) are pleased to announce a collaboration to produce the radioisotope copper-67 (Cu-67) for new cancer therapies. This ... "Iotron is excited about the future for Cu-67 and the opportunity to work with CIIC to make the benefits of this radioisotope ...
Copper Radioisotopes * Integrin alphaV * Oligopeptides * arginyl-glycyl-aspartic acid Grant support * P20 CA86532/CA/NCI NIH ...
Production possibility of copper radioisotopes from cobalt target for PET studies. Szerzők. Szelecsényi F., Kovács Z., Kazutosi ...
... clinicaltrials.gov Menkes Disease is a genetic disorder affecting the metabolism of copper. Patient with this disease are both ... Copper Radioisotopes. Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights ... Copper histidine is a copper replacement that can be injected directly into the body to avoid absorption through the ... Neurotoxicity of Copper.. Copper is an essential trace metal that is required for several important biological processes, ...
Copper Radioisotopes / pharmacokinetics. Dihydrotestosterone / pharmacology. Gene Expression Regulation, Neoplastic / drug ... 0/Androgen Antagonists; 0/Androgens; 0/Antibodies, Monoclonal; 0/Antigens, Surface; 0/Copper Radioisotopes; 0/Heterocyclic ...
Absorption of Copper from the Gastrointestinal Tract The Intestinal Absorption of Zinc Cobalt Absorption. Gastrointestinal ... use of radioisotopes to assess intestinal flux of calcium in humans; and calcium and structure of cell membranes. The ... intestinal absorption of zinc, cobalt, and strontium and absorption of copper from the gastrointestinal tract are underscored. ...
Copper Radioisotopes. 11. 2016. 103. 3.360. Why? Fluorine Radioisotopes. 8. 2020. 471. 2.530. Why? ...
Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem. 2011 Mar 04; 286(9):7389- ... "Phosphorus Radioisotopes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Phosphorus Radioisotopes" by people in Harvard Catalyst ... Below are the most recent publications written about "Phosphorus Radioisotopes" by people in Profiles. ...
Copper (29Cu) has two stable isotopes, 63Cu and 65Cu, along with 27 radioisotopes. The most stable radioisotope is 67Cu with a ... ISBN 978-0-8493-0485-9. Application of Copper radioisotopes in Medicine (Review Paper): Pejman Rowshanfarzad; Mahsheed Sabet; ... Copper offers a relatively large number of radioisotopes that are potentially suitable for use in nuclear medicine. There is a ... Unstable copper isotopes with atomic masses below 63 tend to undergo β+ decay, while isotopes with atomic masses above 65 tend ...
... and TBTAPs suitable for radioactive imaging and therapeutic applications would bear radioisotopes of metals such as copper, ... The cobalt and copper analogs are nonfluorescent. Metal free phthalocyanines are not capable of being rendered reactive or ... Blagrove, R. J., The aggregation of the tetrasodium salt of copper phthalocyanine-4,4,4",4"-tetrasulphonic acid: diffusion ... Radioactive metal complexes of copper 67, technetium 99, cobalt 57, and gallium 67 have been used as radiopharmaceuticals in ...
NorthStar Medical Radioisotopes highlights reliable U.S. Mo-99 production and supply, expansion and R&D advancements in its ... Companys technology expertise being leveraged for commercial production and supply of therapeutic radioisotopes copper-67 (Cu- ... About NorthStar Medical Radioisotopes, LLC (NorthStar) NorthStar Medical Radioisotopes is a nuclear medicine technology company ... high tech radioisotope separation platform indicated for use in producing the widely used medical radioisotope Tc-99m from non- ...
The particle usually comes from the radioactive decay of an atom of a radioisotope, an isotope of an element which is ... Beginning in 1908, luminous paint containing a mixture of radium and copper-doped zinc sulfide was used to paint watch faces ... Radium was used in luminous paint until the 1960s, when it was replaced with the other radioisotopes above due to health ... Phosphors containing silver-doped zinc sulfide (ZnS:Cu) yield blue-green light; copper and manganese-doped zinc sulfide (ZnS:Cu ...
The list cites air pollution by particulates, including radioisotopes strontium-90, and caesium-137; the metals nickel, copper ... 2 copper and nickel smelters (in the so-called Nadezhda complex), which led to bringing substantial numbers of Finnish ... The nickel deposits of Norilsk-Talnakh are the largest-known nickel-copper-palladium deposits in the world. The smelting of the ... Norilsk is the center of a region where nickel, copper, cobalt, platinum, palladium and coal are mined. Mineral deposits in the ...
Radionuclides tentatively on the list are copper-67, germanium-68, indium-111, palladium-103, rhenium-186, samarium-153, and ... The APT site could be a potential U.S. source of radioisotopes to be used in the manufacture of radiopharmaceuticals in nuclear ... Molybdenum will probably not be produced, despite the fact that much of the worlds supply of the short-lived radioisotope is ... Biomedical experts gather to discuss new medical radioisotope sources. @media screen and (max-width: 468px) { .video-detail . ...
Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular ... Zhang P, Zhuang R, Guo Z, Su X, Chen X, Zhang X. A highly efficient copper-mediated radioiodination approach using aryl boronic ... Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular ... Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents. Chem Commun (Camb). 2016; ...
Fermi and his associates succeeded in producing radioisotopes of sodium, iron, copper, gold, and numerous other elements. As a ... RADIOISOTOPE:. An isotope subject to the decay associated with radioactivity. A radioisotope is thus an unstable isotope. ... A radioisotope does not "rot"; it decays by turning into another isotope of the same element-or even into another element ... Yet radioisotopes in general have so many uses, in comparison to stable isotopes, that they are often referred to simply as " ...
Copper is one of the most interesting elements for various biomedical applications. Copper compounds show vast array of ... It also offers a selection of radioisotopes, suitable for nuclear imaging and radiotherapy. Quick progress in nanotechnology ... To date, copper has not found many uses in medicine, but number of ongoing research, as well as preclinical and clinical ... Development of copper based drugs, radiopharmaceuticals and medical materials by Paweł Szymański; Tomasz Frączek; Magdalena ...
There are two stable isotopes of copper: 63Cu and 65Cu. In addition, there are a couple dozen radioisotopes. The vast majority ... Copper (I) compounds : copper(I) chloride, copper(I) oxide.. *Copper (II) compounds : copper(II) carbonate, copper(II) chloride ... copper(II) hydroxide, copper(II) nitrate, copper(II) oxide, copper(II) sulfate, copper(II) sulfide. ... There are numerous alloys of copper-speculum metal is a copper/tin alloy, brass is a copper/zinc alloy, and bronze is a copper/ ...
Gallium-67, Copper-67. a For specific examples of radioisotope applications, refers to Chapters 3 and 4. ... Noninvasive studies of copper metabolism and requirements. • Studies of congenital disorders and body kinetics in ... These materials are used as targets in reactors and accelerators to produce radioisotopes for basic and clinical research (see ... These enriched stable isotopes are used as target materials in the preparation of radioisotopes with particle accelerators and ...
... functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. ... Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic ... functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. ... Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. ...
64Cu and 61Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a ... Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies. Appl. ... Conversely, for the production of copper radioisotopes (61Cu and 64Cu) the irradiated natZn or 64Ni liquid target solution is ... Finally, copper is eluted from the column with water into a final collection vial in the form of a copper chloride solution. In ...
  • J. Carolyn and R. Ferdani, "Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research," Cancer Biotherapy & Radiopharmaceuticals , 2009. (hindawi.com)
  • The APT site could be a potential U.S. source of radioisotopes to be used in the manufacture of radiopharmaceuticals in nuclear medicine. (diagnosticimaging.com)
  • Radioisotopes of iodine have been incorporated into a wide variety of radiopharmaceuticals ranging from small, low molecular weight compounds to large molecules like antibodies. (springer.com)
  • It is thought that personalized treatment of various diseases can be achieved by copper radiopharmaceuticals in the near future. (turkiyeklinikleri.com)
  • For this reason, this review summarizes the recent updates in copper-based nuclear medicine, with specific attention to the diagnostic and therapeutic potential of all medical radioisotopes of copper and included i) copper radioisotopes for medicine, production and properties of copper radioisotopes, ii) design and synthesis of copper radiopharmecuticals, iii) current state of medical uses of copper radiopharmaceuticals, and iv) new trends and requirements for theranostic applications of copper radioisotopes. (turkiyeklinikleri.com)
  • These include the application of radioisotopes in research, industry and medicine, for example radioisotope on-stream analysis, nuclear techniques in hydrology, sterilisation of medical supplies, production and development of radiopharmaceuticals and termite tracing and eradication. (worldwidescience.org)
  • NorthStar's commercialized, U.S.-based radioisotope production is helping to meet patients' needs for important diagnostic imaging radiopharmaceuticals nationwide, and continues to expand. (wisbusiness.com)
  • With a portfolio encompassing promising therapeutic radioisotopes, specialty SPECT imaging agents, and collaborative research for the use of therapeutic radiopharmaceuticals to treat COVID-19 and other acute respiratory diseases, NorthStar is strongly positioned for continued rapid growth. (wisbusiness.com)
  • The data from these studies may invalidate the candidacy of the monooxo-tetraazamacrocyclics as BFCs for copper radiopharmaceuticals. (elsevier.com)
  • The intestinal absorption of zinc, cobalt, and strontium and absorption of copper from the gastrointestinal tract are underscored. (elsevier.com)
  • Beginning in 1908, luminous paint containing a mixture of radium and copper-doped zinc sulfide was used to paint watch faces and instrument dials, giving a greenish glow. (wikipedia.org)
  • copper and manganese-doped zinc sulfide (ZnS:Cu,Mn), yielding yellow-orange light, are also used. (wikipedia.org)
  • Brass , an alloy of zinc and copper, was known to the Greeks but first used extensively by the Romans. (newworldencyclopedia.org)
  • My research dealt with the absorption of the micronutrients iron, manganese, zinc, and copper by tomato plants. (gf.org)
  • I used the radioisotopes iron-55 and iron-59, manganese-52, and zinc-65 as tracers. (gf.org)
  • Can be used on soft metals such as copper, aluminum, zinc and magnesium if rinsed promptly. (alconox.com)
  • Excessive consumption of zinc, use of oral contraceptives, or the drug AZT can lead to copper deficiency, but otherwise deficiency is rare. (thefreedictionary.com)
  • 1984). High levels of dietary iron, zinc, copper and pectin reduce the utilization of ascorbic acid, either by direct oxidation of vitamin C or by reducing its absorption (Sauberlich, 1990). (dsm.com)
  • Unstable isotopes of copper that decay or disintegrate emitting radiation. (umassmed.edu)
  • However, there are only two isotopes of copper, 63Cu and 65Cu, which have 34 and 36 neutrons respectively. (answers.com)
  • Those are the only two stable isotopes of copper. (answers.com)
  • Later, using isotopes of copper, he worked with the UBC Department of Earth, Ocean and Atmospheric Sciences to study the processes whereby phytoplankton swap copper atoms for iron that enable a key metabolic pathway, and how this substitution impacts the plankton's ability to sequester carbon dioxide. (triumf.ca)
  • It also offers a selection of radioisotopes, suitable for nuclear imaging and radiotherapy. (chemweb.com)
  • Because of the routine availability of radioisotopes of iodine with different nuclear decay properties, radioiodination is an attractive strategy because the same chemistry can be utilized for both radionuclide imaging and targeted radiotherapy. (springer.com)
  • The new embedding method provides the utilization of PET imaging in combination with the multituide of uses that AuNPs have found in health technology, and the method can equally well be utilized for therapeutic copper radioisotopes for use in radiotherapy. (dtu.dk)
  • Production possibility of copper radioisotopes from cobalt target for PET studies. (atomki.hu)
  • Nowadays, some cobalt is produced specifically from various metallic-lustered ores, for example cobaltite (CoAsS), but the main source of the element is as a by-product of copper and nickel mining. (phys.org)
  • The copper belt in the Democratic Republic of the Congo and Zambia yields most of the cobalt metal mined worldwide. (phys.org)
  • Cobalt-60 is a commercially important radioisotope, used as a radioactive tracer and in the production of gamma rays. (phys.org)
  • Although neodymium is classed as a rare-earth element, it is fairly common, no rarer than cobalt, nickel, or copper, and is widely distributed in the Earth's crust. (wikipedia.org)
  • The nickel deposits of Norilsk-Talnakh are the largest-known nickel-copper-palladium deposits in the world. (wikipedia.org)
  • From Dudinka, enriched nickel and copper are transported to Murmansk by sea and, then, to the Monchegorsk enrichment and smelting plant on the Kola Peninsula, while more precious content goes up the river to Krasnoyarsk. (wikipedia.org)
  • A number of Finnish companies assisted in the construction and automation of Norilsk's No. 2 copper and nickel smelters (in the so-called Nadezhda complex), which led to bringing substantial numbers of Finnish metallurgical and automation experts and their families to Norilsk starting in 1978, creating a Finnish expat community of some hundreds of people for a couple of years. (wikipedia.org)
  • As tracers it is possible to use chrome-manganese and nickel-copper compounds, whose tendency to hydrolyze permits the fixation of the radioactive tracer on the antigen and antibody respectively. (osti.gov)
  • and (3) Products of bombardment of copper with high energy deuterons and helium ions. (unt.edu)
  • The identity and relative yields of about twenty of the radioisotopes produced by the bombardment of natural copper with 190 Mev deuterons and 380 Mev helium ions have been determined. (unt.edu)
  • Copper ions are homeostatically controlled in all organisms and the control efficiencies increase with trophic chain. (europa.eu)
  • Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete- Part II: Subcellular distribution following sediment exposure. (usgs.gov)
  • Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete - Part I: Relative importance of water and sediment as exposure routes. (usgs.gov)
  • Copper (29Cu) has two stable isotopes, 63Cu and 65Cu, along with 27 radioisotopes. (wikipedia.org)
  • Frank will be instrumental in further expanding NorthStar's Mo-99 production capacity, developing our next generation of technetium-99m (Tc-99m) generators and advancing a game-changing portfolio of new products, including therapeutic radioisotopes copper-67, actinium-225 and SPECT imaging agent, FibroScint. (wisbusiness.com)
  • NorthStar also announced progress in its multi-pronged expansion efforts to ensure a reliable, domestically produced Mo-99 supply for the U.S. healthcare system, an expanded product portfolio and deployment of its technological expertise in scaling up commercial production for therapeutic radioisotopes copper-67 (Cu-67) and actinium (Ac-225). (businesswire.com)
  • We are applying our development expertise towards commercial-scale production of promising therapeutic radioisotopes such as Cu-67 and Ac-225, which may have potential in treating a range of cancers. (businesswire.com)
  • Ruth has become widely recognized for his expertise and work at the leading edge of radioisotope applications in nuclear medicine, from studying the origins and progression of neurological conditions such as Parkinson's disease to future-facing personalized medicine and cancer treatment using therapeutic radioisotopes, including alpha-emitting isotopes . (triumf.ca)
  • The global radioisotope market was valued at $9.6 billion in 2016, with medical radioisotopes accounting for about 80% of this, and it is poised to reach about $17 billion by 2021. (world-nuclear.org)
  • High-grade transvaal chalcopyrite was neutron-irradiated to produce radioisotopes copper- 64, iron-59, and sulfur-35. (cdc.gov)
  • The radioisotopes produced by the inventive method are especially suitable for producing radioisotope-labelled bioconjugates as well as particles, in particular nanoparticles and microparticles. (freepatentsonline.com)
  • Functionalization of gold nanoparticles with monovalent maleimide, by the installation of a maleimide group on nanoparticle via copper-free click chemistry. (sigmaaldrich.com)
  • As a proof-of-concept, we demonstrated successful surface functionalization of the nanoparticles with polyethylene glycol, TRC105 antibody (specific for CD105/endoglin), and 89 Zr (a positron-emitting radioisotope), and enhanced in vivo tumor vasculature-targeted positron emission tomography imaging in 4T1 murine breast tumor-bearing mice. (springer.com)
  • Biokinetics of different-shaped copper oxide nanoparticles in the freshwater gastropod Potamopyrgus antipodarum . (usgs.gov)
  • Copper (symbol Cu , atomic number 29) is one of the oldest known metals in human history. (newworldencyclopedia.org)
  • A ductile malleable metallic element with atomic number 29 that is a component of various enzymes, is used in its salt forms as an astringent, deodorant, and antifungal, and whose radioisotope is used in brain scans and for diagnosing Wilson disease. (thefreedictionary.com)
  • Protein site-specific labeling techniques involve copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction between dibenzocyclooctyne-fluor 545 (DBCO-fluor 545) and an azide-bearing unnatural amino acid (UAA). (sigmaaldrich.com)
  • Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes. (umassmed.edu)
  • The attributes of naturally decaying atoms, known as radioisotopes, give rise to several applications across many aspects of modern day life (see also information paper on The Many Uses of Nuclear Technology ). (world-nuclear.org)
  • Copper (Cu) is an important trace element that acts as a cofactor for many enzymes and proteins that are important for respiration, iron transport, metabolism, cell growth and hemostasis in humans. (turkiyeklinikleri.com)
  • The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. (europa.eu)
  • Copper acts as an active cofactor in over 20 enzymes and proteins, notably the respiratory enzymes haemocyanin and cytochrome oxidase and the anti-oxidant superoxide dismutase (WHO, 1998). (europa.eu)
  • Copper is bound to proteins such as ceruloplasmin and metallothionenin, functioning as copper storage and mobilised as needed. (europa.eu)
  • Proteomic Analysis of Copper-Binding Proteins in Excess Copper-Stressed Roots of Two Rice (Oryza sativa L.) Varieties with Different Cu Tolerances. (jove.com)
  • The most stable radioisotope is 67Cu with a half-life of 61.83 hours, while the least stable is 54Cu with a half-life of approximately 75 ns. (wikipedia.org)
  • These enriched stable isotopes are used as target materials in the preparation of radioisotopes with particle accelerators and nuclear reactors and as biological tracers in biomedical research and clinical applications. (nap.edu)
  • Argonne's work in radioisotopes is supported by the DOE Isotope Program, which is the global leader in producing and distributing radioactive and enriched stable isotopes that are deemed critical or are in short supply. (infosurhoy.com)
  • I used nitrogen and carbon stable isotopes to show that cadmium, in contrast to copper, could be magnified along certain freshwater food webs. (usgs.gov)
  • In addition to my work on metal trophic transfer, I refined an approach that involves the use stable metal isotopes (rather than radioisotopes) to describe accumulation and loss dynamics in freshwater invertebrates. (usgs.gov)
  • In all, 31 radioisotopes of neodymium have been detected as of 2010[update], with the most stable radioisotopes being the naturally occurring ones: 144Nd (alpha decay with a half-life (t1/2) of 2.29×1015 years) and 150Nd (double beta decay, t1/2 = 7×1018 years, approximately). (wikipedia.org)
  • Menkes Disease is a genetic disorder affecting the metabolism of copper. (bioportfolio.com)
  • However, patients with severe abnormalities of the genes responsible for copper metabolism may receive no benefit from copper replacement. (bioportfolio.com)
  • The knowledge gained assisted us to design new radiotracer for diagnostic of hypoxic tumors (described in WP2) and peptides that can manipulate the copper metabolism, towards development of new therapeutic agents to neurological diseases (WP3). (europa.eu)
  • Copper (Cu) is required by the body as a cofactor or regulator in many important physiological processes such as cell signaling, cellular respiration, free-radical defence, neurotransmitter synthesis, neuronal myelination, and iron metabolism. (rsc.org)
  • Several radioisotopes of Cu are available that could assist studies of trafficking and metabolism of Cu, although they have been used surprisingly infrequently for this purpose so far. (rsc.org)
  • Tetraazamacrocyclic ligands are the most widely used bifunctional chelators (BFCs) for attaching copper radionuclides to antibodies and peptides due to their relatively high kinetic stability. (elsevier.com)
  • NorthStar's RadioGenix System is an innovative, high tech radioisotope separation platform indicated for use in producing the widely used medical radioisotope Tc-99m from non-uranium based molybdenum-99 (Mo-99). (businesswire.com)
  • We will utilize the knowledge gained in this study on the copper cycle to develop biomimetic peptides to control the in-cell copper concentration. (europa.eu)
  • WP 3.1: Design biomimetic peptides that can alter the cellular copper trafficking mechanism. (europa.eu)
  • How many protons and neutrons are there in copper 63? (answers.com)
  • nThere are 29 Protons and 34 Neutrons in Copper-63. (answers.com)
  • There are also 29 Protons and 36 Neutrons in Copper-65. (answers.com)
  • What is the number of protons electrons and neutrons copper has? (answers.com)
  • Copper has 29 protons, 34 or 36 neutrons (depending on which isotope) and 29 electrons. (answers.com)
  • The resulting photo-nuclear reaction ejects one or more protons or neutrons to make the desired radioisotope: copper-67 in this case. (infosurhoy.com)
  • Copper compounds show vast array of biological actions, including anti-inflammatory, anti-proliferative, biocidal and other. (chemweb.com)
  • Conversely, reduction of their compounds to the pure metal is easiest for gold, and diminishes through silver to copper 1 . (h2g2.com)
  • If the stones had happened to contain copper and/or tin compounds, the metals would flow out as liquids and quickly harden into lumps. (h2g2.com)
  • Radioluminescence is also sometimes seen around high-power radiation sources, such as nuclear reactors and radioisotopes. (wikipedia.org)
  • In addition, as copper is a biostatic material, copper surfaces and doorknobs are used in hospitals to prevent the transfer of germs, and copper (II) sulfate is used as a fungicide. (newworldencyclopedia.org)
  • copper sulfate cupric sulfate . (thefreedictionary.com)
  • The method is being used on a routine basis on both sulfate and nitrate solutions containing copper concentrations from 0 to over 100 g/l. (cdc.gov)
  • Diagnostic procedures using radioisotopes are now routine. (world-nuclear.org)
  • In developed countries (a quarter of the world population) about one person in 50 uses diagnostic nuclear medicine each year, and the frequency of therapy with radioisotopes is about one-tenth of this. (world-nuclear.org)
  • The most common radioisotope used in diagnosis is technetium-99 (Tc-99), with some 40 million procedures per year, accounting for about 80% of all nuclear medicine procedures and 85% of diagnostic scans in nuclear medicine worldwide. (world-nuclear.org)
  • Radioisotopes are an essential part of medical diagnostic procedures. (world-nuclear.org)
  • PET imaging with 64 Cu could help understand changes in brain copper dynamics in AD and underpin new clinical diagnostic imaging methods. (rsc.org)
  • The first is diagnostic, where the radioisotope allows doctors to visualize a tumor's precise location and contours within the body with greater clarity than an MRI scan provides. (infosurhoy.com)
  • His work, along with the Wolf group's work to identify radioisotopes that could be used for PET scanning, helped drive acceptance for PET imaging and eventually paved the way for the wider development of diagnostic and therapeutic nuclear medicine techniques. (triumf.ca)
  • In recent years specialists have also come from radiology, as dual PET/CT (positron emission tomography with computerised tomography) procedures have become established, increasing the role of accelerators in radioisotope production. (world-nuclear.org)
  • Radiotracer [ 64 Cu]DOTA-ADIBON 3 -Ala-PEG 28 -A20FMDV2, used for positron emission tomography imaging of integrin α v β 6 expressing tumors, has been synthesized via copper-free click chemistry. (sigmaaldrich.com)
  • Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), thereby allowing the imaging and quantification of HER2-expressing tumor cells. (cancer.gov)
  • This article focusses on acute changes in copper trafficking, particularly influx and efflux in brain, and how it is altered in a mouse model of Alzheimer's disease compared to normal mice, and highlights the growing opportunity to use positron emission tomography in the study of metallomics at the whole body level in animals and humans. (rsc.org)
  • The radiotracer approach is given added power by the growing availability of positron emission tomography (PET), which allows positron-emitting radioisotopes to be used to map acute copper trafficking processes across the whole body longitudinally and non-invasively in living humans and animals. (rsc.org)
  • Of the available positron-emitting copper radioisotopes, 64 Cu is the most practical due to its relatively long half life ( t 1/2 = 12.7 h) which offers a relatively large time window (2-3 days) for PET imaging. (rsc.org)
  • In addition, the photosensitizer is a fluorescent dye and it can bind the radioisotope copper-64, which enables visualization with both fluorescence imaging and positron emission tomography (PET). (researchsea.com)
  • Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). (elsevier.com)
  • The aim of the present study was to develop and implement an approach to quantify regional myocardial perfusion using copper(II) pyruvaldehyde bis-(N 4 -thiosemicarbazone) (PTSM) labeled with the generator-produced, positron-emitting radionuclide 62 Cu (t 1/2 =9.7 minutes). (elsevier.com)
  • Iodine radioisotope labeling of cyclooctyne-containing molecules by copper-free click reaction has been reported. (sigmaaldrich.com)
  • This method is useful for both in vitro and in vivo labeling of DBCO group containing molecules with iodine radioisotopes. (sigmaaldrich.com)
  • Park, S. H. Efficient method for iodine radioisotope labeling of cyclooctyne-containing molecules using strain-promoted copper-free click reaction. (alfa.com)
  • Nuclear accidents such as Fukushima (or nuclear war) can expose your body to radioactive iodine-131, a dangerous radioisotope. (naturalnews.com)
  • 4) the comparison between copper toxicity from dietary versus waterborne exposures. (europa.eu)
  • Water-borne exposure (not diet borne exposure) is the exposure route critical to copper toxicity. (europa.eu)
  • The aim of treatment is to bypass the normal route of absorption of copper through the gastrointestinal tract. (bioportfolio.com)
  • Copper histidine is a copper replacement that can be injected directly into the body to avoid absorption through the gastrointestinal tract. (bioportfolio.com)
  • Several issues must be addressed in configuring therapeutic strategies for this disorder: (a) affected infants must be identified and treatment commenced very early in life before irreparable neurodegeneration occurs, (b) the block in intestinal absorption of copper must be bypassed, (c) circulating copper must be delivered to the brain, and (d) copper must be available to enzymes within cells that require it as a cofactor. (bioportfolio.com)
  • Members of the biomedical sciences community, as well as representatives of the radiopharmaceutical industry, are recommending that the production of medical radioisotopes be included in the APT site's charter. (diagnosticimaging.com)
  • However, the data presented here suggest that neutral or negatively charged Cu(II) complexes of tetraazamacrocyclic ligands with a cyclam backbone (tetradecane) are optimal for copper radiopharmaceutical applications. (elsevier.com)
  • Copper is the one of the new radioisotopes in Nuclear Medicine that can be used for different metabolic imaging of several organs and systems. (turkiyeklinikleri.com)
  • Insufficient bioavailable copper in soils has been shown to reduce agricultural yields and to produce metabolic copper deficiencies in animals. (europa.eu)
  • Depending on the organism's metabolic need, different copper levels are found in tissues from different strains, species and life stages. (europa.eu)
  • A lower "k" indicates a higher percent of copper or silver mixed into the alloy, with copper being the more commonly used metal between the two. (citizendium.org)
  • Fourteen karat gold-copper alloy will be nearly identical in color to certain bronze alloys, and both may be used to produce police and other badges. (citizendium.org)
  • The Bronze Age started when copper and tin were mixed, probably accidentally, to make the alloy we now know as bronze - a much harder metal than either copper or tin alone. (h2g2.com)
  • Copper is malleable and ductile - both easily beaten into shape or drawn out into wires. (h2g2.com)
  • High purity production and potential applications of copper-60 and copper-61," Nuclear Medicine and Biology , vol. 26, no. 4, pp. 351-358, 1999. (hindawi.com)
  • In higher organisms (vertebrates), homeostatic control of copper supply is achieved mainly by storage in the liver and biliary secretion (Underwood and Suttle, 1999). (europa.eu)
  • Menkes disease is an X-linked recessive neurodegenerative disorder caused by defects in a gene that encodes an evolutionarily conserved copper-transporting ATPase (ATP7A). (bioportfolio.com)
  • Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). (harvard.edu)
  • 75 or 88 or 107, speaking as we find 1675 substances( online Clinical and Radiological Aspects of Myopathies: CT Scanning · EMG · Radioisotopes 1982. (ballroomchicago.com)
  • Though nowadays it is found in combination with other substances, when we first became interested in its properties about 5000 BC, there was probably enough natural metallic copper 5 around to be found readily. (h2g2.com)
  • To date, copper has not found many uses in medicine, but number of ongoing research, as well as preclinical and clinical studies, will most likely lead to many novel applications of copper in the near future. (chemweb.com)
  • There is widespread awareness of the use of radiation and radioisotopes in medicine, particularly for diagnosis (identification) and therapy (treatment) of various medical conditions. (world-nuclear.org)
  • Copper Radioisotopes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Triazole analogs of phthalate plasticizers (PVC-DEHT, PVC-DBT and PVC-DMT) have been prepared by copper-free azide-alkyne click reaction. (sigmaaldrich.com)
  • Di(2-ethylhexyl)-1 H -triazole-4,5-dicarboxylate (DEHT), di( n -butyl)-1 H- 1,2,3-triazole-4,5-dicarboxylate (DBT), and di(methyl)-1 H -triazole-4,5-dicarboxylate (DMT) are covalently attached to azide-functionalized polyvinyl chloride (PVC) via copper free-click reaction. (sigmaaldrich.com)
  • Novel class of difluorinated cyclooctyne (DIFO) reagents were employed in copper-free click chemistry for the site-selective labeling of biomolecules in vitro and in vivo. (sigmaaldrich.com)
  • Immobilization of the Gas Signaling Molecule H2 S by Radioisotopes: Detection, Quantification, and In Vivo Imaging. (nih.gov)
  • Herein, we report the first radioisotope-based immobilization technique for the detection, quantification, and in vivo imaging of endogenous H2 S. Macrocyclic (64) Cu complexes that instantly reacted with gaseous H2 S to form insoluble (64) CuS in a highly sensitive and selective manner were prepared. (nih.gov)
  • If a liver examination is necessary, the doctor might order a computerized axial tomography ( CAT ) scan, ultrasound, a scan of the liver using a radioisotope , or look at the liver using a laparoscope . (digitalnaturopath.com)
  • The data have been reviewed by two authors in view of assessing the relation between the CuBCF/BAF values and the copper concentrations in the water and sediment. (europa.eu)
  • Field data further show that copper concentrations in tissues of marine mammals and coastal seabirds, regardless of species, except brain, tend to decrease with increasing age (Eisler 1984, Lock et al. (europa.eu)
  • Playle,1993a demonstrated that copper concentrations in the target organ (gills) correlates to the free copper concentration, not to the total copper concentration in the test water. (europa.eu)
  • However due to the homeostatic regulation of copper (and other metals), theBCF/BAF are not independent of exposure concentration (Review papers of Adams et al. (europa.eu)
  • Aquatic invertebrates such as gastropods, some crustacea and bivalves, relying on haemoocyanin as respiratory pigment, have typically higher copper levels than invertebrates relying on haemoglobin as respiratory pigment (e.g. (europa.eu)
  • 1992). Neonatal marine mammals have higher copper levels compared to the mothers (Law et al. (europa.eu)
  • pper-64 Cu-I Copper sulphate in sulphUriC acid solution. (endemunde.it)
  • Adding copper yields a redder metal, iron blue, aluminium purple, platinum metals white, and natural bismuth together with silver alloys produce black. (citizendium.org)
  • Unstable copper isotopes with atomic masses below 63 tend to undergo β+ decay, while isotopes with atomic masses above 65 tend to undergo β− decay. (wikipedia.org)
  • The research was focused on studies of nutritional anemias in pigs due to deficiencies of copper, amino acids and various vitamins. (utah.edu)
  • Weisman, Wong, and coworkers (23 , 24) have synthesized and characterized a series of copper (II) cross-bridged cyclam complexes that demonstrate improved kinetic stability compared with TETA complexes. (aacrjournals.org)
  • 7 Difluorinated cyclooctyne reagents have been reported to be useful for the copper-free click chemistry. (sigmaaldrich.com)
  • There is a considerable amount of copper accumulation data available, that could potentially be used to calculate bioconcentration factors ( BCF ) and bioaccumulation factors (BAF) and assess the corresponding potential risks in aquatic food chains. (europa.eu)
  • CIIC and Iotron are proud to establish the world's first private sector producer and supplier of this valuable radioisotope, building on the application innovations and accelerator expertise of both parties. (canadianisotopes.ca)
  • Copper-67 is an especially valuable radioisotope because it is theragnostic and because we have a way to produce it in quantities that would be useful to hospitals," said Dave Rotsch, an Argonne chemist and deputy program manager of Argonne's radioisotope program. (infosurhoy.com)
  • The present invention relates to an universal method for the large scale production of high-purity carrier free or non carrier added radioisotopes by applying a number of "unit operations" which are derived from physics and material science and hitherto not used for isotope production. (freepatentsonline.com)
  • A required number of said unit operations is combined, selected and optimised individually for each radioisotope production scheme. (freepatentsonline.com)
  • 1. A method for the large scale production of high-purity carrier-free or non-carrier added radioisotopes comprising the following steps: (a) Activation of a target by a particle beam, (b) Separation of the isotope from the irradiated target, (c) Ionisation of the separated isotope, (d) Extraction from the ion source and acceleration of the ion beam, (e) Mass-separation, and (f) Collection of the isotope. (freepatentsonline.com)
  • Patients with a genetic abnormality that may still permit some production of the enzymes required to process copper may receive benefit from early treatment with copper replacement. (bioportfolio.com)
  • BUSINESS WIRE )--NorthStar Medical Radioisotopes, LLC, a global innovator in the production and distribution of radioisotopes used for medical imaging, today announced a corporate update highlighting the continued commercial progress of its RadioGenix® System (technetium Tc 99m generator). (businesswire.com)
  • This will enhance production efficiencies and complete the creation of dual manufacturing operations to further secure reliable, non-uranium based Mo-99 radioisotope supply for U.S. customers and patients. (businesswire.com)
  • The method is suitable for the production and purification of radiometals such as 68 Ga, 64 Cu and 61 Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a substantial reduction in processing time and cost when compared with the solid target approach. (mdpi.com)
  • The methods described allow the production of radioisotopes-such as 68 Ga, 64 Cu, 61 Cu and others-through the irradiation of liquid targets, with a substantial reduction in processing time and cost when compared with the solid target approach. (mdpi.com)