A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

The intra- and inter-assay variation of the indirect mixed antiglobulin reaction test: is a quality control suitable? (1/208)

The test most commonly used to detect sperm antibodies is the mixed antiglobulin reaction (MAR), standardized by the World Health Organization. The indirect MAR test detects soluble sperm antibodies in seminal plasma by using healthy donor spermatozoa as antigen. In this study we systematically investigated the influence of donor spermatozoa and the source of sperm antibodies upon the results of the indirect MAR test, and calculated the intra- and inter-assay variations. Using one individual seminal plasma and the same donor semen, results of the indirect MAR test are highly reproducible (low intra-assay variation). Two dimensions of inter-assay variation must be considered: (i) serial ejaculates of an individual donor may be used at different times; (ii) different donors may be applied to identical antibody sources. Donor spermatozoa strongly influenced the results of the indirect MAR test. Using multivariate statistical tests, highly significant main effects between the different donors (P < 0.001) and specific reciprocal effects between donor spermatozoa and seminal plasma samples (P < 0.001) were observed. The high inter-assay variation of the indirect MAR test will lead to incorrect results. There is urgent need of a reliable and reproducible test for sperm antibody detection to improve quality control of the methods.  (+info)

A persistent severe autoimmune hemolytic anemia despite apparent direct antiglobulin test negativization. (2/208)

BACKGROUND AND OBJECTIVE: Not all cases of autoimmune hemolytic anemia (AIHA) are diagnosed by the direct antiglobulin test (DAT). We present and discuss a simple method of enhancing the sensitivity of the standard DAT. DESIGN AND METHODS: We report the case of a five-month-old child diagnosed with a severe IgG-mediated AIHA, characterized by quick DAT negativization despite clinical worsening. Warm AIHA with negative DAT, possibly due to a low affinity autoantibody, unresponsive to conventional therapy, was hypothesized. RESULTS: The DAT resulted strongly positive with anti-IgG serum using a 4C saline for erythrocyte washing, to reduce the dissociation of the supposed low affinity autoantibody. Very intensive cytoreductive treatment was administered twice until clinical remission was obtained. INTERPRETATION AND CONCLUSIONS: The clinical course of AIHA can be dissociated by the DAT. Since autoantibody-mediated hemolysis with negative DAT rarely occurs, once other causes of high reticulocyte count anemia have been ruled out, the DAT after ice-cold saline washing could be a useful and easy means of corroborating the diagnosis of AHIA, when traditional methods fail.  (+info)

Posttreatment follow-Up of brucellosis by PCR assay. (3/208)

In order to evaluate the usefulness of a peripheral blood PCR assay in the posttreatment follow-up of brucellosis, a cohort of 30 patients was studied by means of blood cultures, rose Bengal, seroagglutination, Coombs' antibrucella tests, and PCR assay at the time of diagnosis, at the end of treatment, and 2, 4, and 6 months later. Of the 29 patients whose PCR assays were initially positive, 28 (96.5%) were negative at the conclusion of the treatment. PCR was positive for the two patients who had relapses and negative for another four who had suspected but unconfirmed relapses. PCR was negative for 98.3% of the follow-up samples from those patients who had a favorable evolution. In conclusion, PCR appears to be a very useful technique, not only for the initial diagnosis of the disease, but also for posttreatment follow-up and the early detection of relapses.  (+info)

Relative sensitivity of direct antiglobulin test, antibody's elution and flow cytometry in the serologic diagnosis of immune hemolytic transfusion reactions. (4/208)

BACKGROUND AND OBJECTIVE: Current immunohematology practice dictates that serologic diagnosis of immune hemolytic transfusion reactions (IHTR) is based on the finding of a positive post-transfusion direct antiglobulin test (DAT). However, since DAT may fail to detect antibody-coated cells when they constitute a minor population amid a large number of non-sensitized ones, we investigated whether antibody detection in eluates or by flow cytometry is more sensitive than DAT in this context. DESIGN AND METHODS: Ten samples of red blood cells sensitized with allo- or autoantibodies were diluted in non-sensitized red blood cells to final concentrations ranging from 10% to 0.1%. DAT, antibody detection in eluates, and immunofluorescence by flow cytometry were performed on each mixture. RESULTS: DAT failed to detect sensitized cells in all but two cases in that only the 10% dilution yielded a positive DAT. Antibody detection in eluates and by flow cytometry was able to detect up to 1% sensitized cells in most cases. INTERPRETATION AND CONCLUSIONS: Antibody detection in eluates and by flow cytometry is more sensitive than DAT for detecting minor populations of IgG-coated cells. These techniques should be included in the routine investigation of suspected cases of IHTR.  (+info)

Allogeneic peripheral blood hematopoietic stem cell transplantation: guidelines for red blood cell immuno-hematological assessment and transfusion practice.Societe Francaise de Greffe de Moelle. (5/208)

Allogeneic peripheral blood hematopoietic stem cell transplantation (PBSCT) is presently being evaluated in a French randomized study comparing peripheral blood vs bone marrow. Cases of potentially lethal acute hemolysis have recently been reported after allogeneic PBSCT in the presence of a 'minor' ABO incompatibility. Patients were frequently transfused with recipient-compatible and donor-incompatible RBC and usually did not receive methotrexate in addition to cyclosporin A for graft-versus-host disease (GVHD) prophylaxis. In order to homogenize immuno-hematological (IH) assessment and transfusion practices within our protocol, we made proposals to 25 allo-transplant French centers on the following aspects: pre-inclusion IH assessment, IH exclusion criteria, transfusion rules, post-transplant IH surveillance and treatment of hemolysis. Analysis of responses to our proposals led to the elaboration of guidelines which were approved and implemented by the French Bone Marrow Transplantation Society (SFGM). Pre-inclusion IH testing includes mandatory detection and titration of anti-RBC allo-Ab, as well as titration of anti-A and anti-B Ab. The presence in the donor of an anti-A (group A or AB recipients), anti-B (group B or AB recipients) Ab with a titer >1/32 or the presence of allo-Ab against Rh, Kell, Fya, Fyb, Jka, Jkb, Ss Ag present on recipient RBC is an exclusion criterion for the protocol. ABO and RhD compatibility of RBC blood products with both HSC donor and recipient is mandatory. A similar compatibility is also required for Rh (other than D) and Kell Ag. If not possible, compatibility of RBC blood products with the HSC donor is mandatory. Lastly, guidelines regarding post-transplantation IH follow-up as well as acute hemolysis treatment have been elaborated. The implementation of these guidelines should contribute to enhancing the quality of transfusion practice after PBSCT. Such an approach will be applied to other aspects of transfusion medicine in the setting of HSC transplantation. Bone Marrow Transplantation(2000) 25, 507-512.  (+info)

Unrelated umbilical cord blood transplantation in infancy for mucopolysaccharidosis type IIB (Hunter syndrome) complicated by autoimmune hemolytic anemia. (6/208)

This report describes unrelated umbilical cord blood transplantation for a 10-month-old infant boy with mucopolysaccharidosis IIB (Hunter syndrome), an X-linked metabolic storage disorder due to deficiency of iduronate sulfatase. Two years after transplant approximately 55% normal plasma enzyme activity has been restored and abnormal urinary excretion of glycosaminoglycans has nearly completely resolved. The boy has exhibited normal growth and development after transplant. Nine months after transplant he developed severe autoimmune hemolytic anemia and required 14 months of corticosteroid treatment to prevent clinically significant anemia. Bone marrow transplantation for Hunter syndrome and post-transplant hemolytic anemia are reviewed. Bone Marrow Transplantation (2000).  (+info)

Modification of the immunogenicity and antigenicity of rat hepatoma cells. I. Cell-surface stabilization with glutaraldehyde. (7/208)

gamma-Irradiated rat hepatoma cells are immunogenic in syngeneic WAB/Not rats, so that immunized animals are protected against tumour-cell challenge and circulating tumour-specific antibody is produced. Treatment of the immunizing cells with glutaraldehyde at concentrations of 0.001% or greater for 30 min rendered these cells non-protective in tumour-rejection tests and no longer able to induce significant formation of specific antibody. However, tumour-specific antigens were shown to be expressed upon treated cells; they specifically bound tumour-specific antibody from syngeneic immune sera assessed in indirect membrane-immunofluorescence tests. Also, these cells specifically absorbed antibody from immune or tumour-bearer sera, as demonstrated in the indirect membrane-immunofluorescence test or a complement-dependent 51Cr-release test. Alloantigen expression was not influenced by glutaraldehyde treatment, although glutaraldehyde-treated hepatoma cells failed to induce alloantibody formation in KX/Not rats. Polyacrylamide-gel electrophoresis of treated cells, surface-labelled with 125I, indicated that extensive cross-linking of the surface protein occurred as a result of glutaraldehyde treatment. The present findings establish that although the expression of a tumour-specific antigen is necessary for the induction of immuno-protection against tumour-cell challenge, this alone is not a sufficient condition for eliciting tumour immunity.  (+info)

Poly IC therapy in aleutian disease of mink. (8/208)

Twenty-four virgin female aleutian mink were infected with aleutian disease agent and after 24 hours, 12 of these were treated with a course of polyinosinic acid-polycytidilic acid (Poly IC) injections. After six weeks the gammaglobulin level was significantly lower in the treated group but at 12 weeks this difference was no longer present. Four of the treated mink had normal target organ histology when killed at 20 weeks. The untreated group all showed moderate to marked changes but this difference was not statistically significant. There was a marked increase in the reactive lymphocyte blastogenesis index during the first weeks of infection and the phytohaemagglutinin response was seen to fall progressively. The antiglobulin reaction usually became positive after infection but neither antinuclear nor antierythrocyte antibodies were found. Precipitating antibodies to several polynucleotides were frequently present and were unrelated to infection or to Poly IC treatment.  (+info)

The Coombs test is a laboratory procedure used to detect the presence of antibodies on the surface of red blood cells (RBCs). It is named after the scientist, Robin Coombs, who developed the test. There are two types of Coombs tests: direct and indirect.

1. Direct Coombs Test (DCT): This test is used to detect the presence of antibodies directly attached to the surface of RBCs. It is often used to diagnose hemolytic anemia, a condition in which RBCs are destroyed prematurely, leading to anemia. A positive DCT indicates that the patient's RBCs have been coated with antibodies, which can occur due to various reasons such as autoimmune disorders, blood transfusion reactions, or drug-induced immune hemolysis.
2. Indirect Coombs Test (ICT): This test is used to detect the presence of antibodies in the patient's serum that can agglutinate (clump) foreign RBCs. It is commonly used before blood transfusions or during pregnancy to determine if the patient has antibodies against the RBCs of a potential donor or fetus, respectively. A positive ICT indicates that the patient's serum contains antibodies capable of binding to and agglutinating foreign RBCs.

In summary, the Coombs test is a crucial diagnostic tool in identifying various hemolytic disorders and ensuring safe blood transfusions by detecting the presence of harmful antibodies against RBCs.

Hemolytic anemia, autoimmune is a type of anemia characterized by the premature destruction of red blood cells (RBCs) in which the immune system mistakenly attacks and destroys its own RBCs. This occurs when the body produces autoantibodies that bind to the surface of RBCs, leading to their rupture (hemolysis). The symptoms may include fatigue, weakness, shortness of breath, and dark colored urine. The diagnosis is made through blood tests that measure the number and size of RBCs, reticulocyte count, and the presence of autoantibodies. Treatment typically involves suppressing the immune system with medications such as corticosteroids or immunosuppressive drugs, and sometimes removal of the spleen (splenectomy) may be necessary.

Brucellosis is a bacterial infection caused by the Brucella species, which are gram-negative coccobacilli. It is a zoonotic disease, meaning it can be transmitted from animals to humans. The most common way for humans to contract brucellosis is through consumption of contaminated animal products, such as unpasteurized milk or undercooked meat, from infected animals like goats, sheep, and cattle.

Humans can also acquire the infection through direct contact with infected animals, their tissues, or bodily fluids, especially in occupational settings like farming, veterinary medicine, or slaughterhouses. In rare cases, inhalation of contaminated aerosols or laboratory exposure can lead to brucellosis.

The onset of symptoms is usually insidious and may include fever, chills, night sweats, headache, muscle and joint pain, fatigue, and loss of appetite. The infection can disseminate to various organs, causing complications such as endocarditis, hepatomegaly, splenomegaly, orchitis, and epididymoorchitis.

Diagnosis is confirmed through blood cultures, serological tests, or molecular methods like PCR. Treatment typically involves a long course of antibiotics, such as doxycycline combined with rifampin or streptomycin. Prevention measures include pasteurization of dairy products and cooking meat thoroughly before consumption. Vaccination is available for high-risk populations but not for general use due to the risk of adverse reactions and potential interference with serodiagnosis.

Agglutination tests are laboratory diagnostic procedures used to detect the presence of antibodies or antigens in a sample, such as blood or serum. These tests work by observing the clumping (agglutination) of particles, like red blood cells or bacteriophages, coated with specific antigens or antibodies when mixed with a patient's sample.

In an agglutination test, the sample is typically combined with a reagent containing known antigens or antibodies on the surface of particles, such as latex beads, red blood cells, or bacteriophages. If the sample contains the corresponding antibodies or antigens, they will bind to the particles, forming visible clumps or agglutinates. The presence and strength of agglutination are then assessed visually or with automated equipment to determine the presence and quantity of the target antigen or antibody in the sample.

Agglutination tests are widely used in medical diagnostics for various applications, including:

1. Bacterial and viral infections: To identify specific bacterial or viral antigens in a patient's sample, such as group A Streptococcus, Legionella pneumophila, or HIV.
2. Blood typing: To determine the ABO blood group and Rh type of a donor or recipient before a blood transfusion or organ transplantation.
3. Autoimmune diseases: To detect autoantibodies in patients with suspected autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus, or Hashimoto's thyroiditis.
4. Allergies: To identify specific IgE antibodies in a patient's sample to determine allergic reactions to various substances, such as pollen, food, or venom.
5. Drug monitoring: To detect and quantify the presence of drug-induced antibodies, such as those developed in response to penicillin or hydralazine therapy.

Agglutination tests are simple, rapid, and cost-effective diagnostic tools that provide valuable information for clinical decision-making and patient management. However, they may have limitations, including potential cross-reactivity with other antigens, false-positive results due to rheumatoid factors or heterophile antibodies, and false-negative results due to the prozone effect or insufficient sensitivity. Therefore, it is essential to interpret agglutination test results in conjunction with clinical findings and other laboratory data.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Hemolytic anemia is a type of anemia that occurs when red blood cells are destroyed (hemolysis) faster than they can be produced. Red blood cells are essential for carrying oxygen throughout the body. When they are destroyed, hemoglobin and other cellular components are released into the bloodstream, which can lead to complications such as kidney damage and gallstones.

Hemolytic anemia can be inherited or acquired. Inherited forms of the condition may result from genetic defects that affect the structure or function of red blood cells. Acquired forms of hemolytic anemia can be caused by various factors, including infections, medications, autoimmune disorders, and certain medical conditions such as cancer or blood disorders.

Symptoms of hemolytic anemia may include fatigue, weakness, shortness of breath, pale skin, jaundice (yellowing of the skin and eyes), dark urine, and a rapid heartbeat. Treatment for hemolytic anemia depends on the underlying cause and may include medications, blood transfusions, or surgery.

Erythrocytes, also known as red blood cells (RBCs), are the most common type of blood cell in circulating blood in mammals. They are responsible for transporting oxygen from the lungs to the body's tissues and carbon dioxide from the tissues to the lungs.

Erythrocytes are formed in the bone marrow and have a biconcave shape, which allows them to fold and bend easily as they pass through narrow blood vessels. They do not have a nucleus or mitochondria, which makes them more flexible but also limits their ability to reproduce or repair themselves.

In humans, erythrocytes are typically disc-shaped and measure about 7 micrometers in diameter. They contain the protein hemoglobin, which binds to oxygen and gives blood its red color. The lifespan of an erythrocyte is approximately 120 days, after which it is broken down in the liver and spleen.

Abnormalities in erythrocyte count or function can lead to various medical conditions, such as anemia, polycythemia, and sickle cell disease.

If clumping is seen, the Coombs test is positive; if not, the Coombs test is negative. Common clinical uses of the Coombs test ... The indirect Coombs test is used in prenatal testing of pregnant women and in testing prior to a blood transfusion. The test ... also known as Coombs antiglobulin or antihuman globulin) is used in both the direct Coombs test and the indirect Coombs test. ... Coombs' test- Medlineplus.org. Drugs that cause haemolytic anemia - Merck Manual. Coombs'+Test at the U.S. National Library of ...
Coombs test, an aid to medical diagnosis. Coomb Teak or Gmelina arborea, a medicinal tree. Deeping Coomb, a fictional deep ... Coomb is an alternate spelling of combe. It may also refer to: Arthur Coomb (born 1929), English cricketer Coomb (unit), a unit ... This disambiguation page lists articles associated with the title Coomb. If an internal link led you here, you may wish to ...
This is the test now referred to as the Coombs test, which, according to the legend, was first devised while Coombs was ... Coombs RR, Mourant AE, Race RR (1945). "Detection of weak and "incomplete" Rh agglutinins: a new test". Lancet. 246 (6358): 15- ... Coombs RR (1998). "Historical note: past, present and future of the antiglobulin test". Vox Sang. 74 (2): 67-73. doi:10.1159/ ... Biography portal Medicine portal The Coombs test, which he developed and published together with Arthur Mourant and Robert ...
Also in 1953, Coombs earned a test at Snetterton with the Connaught Engineering factory team, alongside Roy Salvadori, Jack ... "Lunch with John Coombs". Motor Sport Magazine. May 2009. Retrieved 9 August 2013. "John Coombs". The 500 Owners Association. ... Salvadori was fastest with Coombs second, and Coombs was subsequently entered into a number of Formula Two races both in the UK ... In 1961 Coombs used the new Jaguar E-Type, and by the following year, Graham Hill had joined his list of drivers. He also ...
Testing Coombs - after birth baby will have a direct coombs test run to confirm antibodies attached to the infant's red blood ... Routine antenatal antibody screening blood tests (indirect Coombs test) do not screen for ABO HDN.[citation needed] If IgG anti ... An indirect coombs needs to be run in cases of anti-C, anti-c, and anti-M. Anti-M also recommends antigen testing to rule out ... This test is run from cord blood. In some cases, the direct coombs will be negative but severe, even fatal HDN can occur. ...
Indirect Coombs test (AGT) to assess risk of hemolytic disease of the newborn Rapid plasma reagin test to screen for syphilis ... Rath L. "What Is a Coombs Test?". WebMD. Retrieved 2022-04-29. Rath L. "Why Do I Need a Rubella Test?". WebMD. Retrieved 2022- ... Nonstress test (NST) for fetal heart rate Oxytocin challenge test A pregnant woman may have a pre-existing disease, that may ... Glucose loading test (GLT) - screens for gestational diabetes; if > 140 mg/dL, a glucose tolerance test (GTT) is administered; ...
Ackerman, D. L. (1991). "A History of Drug Testing". In Coombs, Robert H.; West, Louis Jolyon (eds.). Drug testing: Issues and ... Because the metabolites may persist in the blood for many days, the test may detect marijuana that was used many days earlier ... Another crew member also tested positive, but was reported to have not been working on the ship. On 27 April, Nimitz completed ... Bertrand, Natasha & Seligman, Lara (7 April 2020). "Sailor aboard 4th U.S. aircraft carrier tests positive for coronavirus". ...
Robin Coombs, 84, British immunologist, developed Coombs Antibody test Marion Dudley, 33, American convicted murderer, executed ... Richmond, Caroline (March 6, 2006). "Professor Robin Coombs: Inventor of the Coombs test". The Independent. Retrieved June 16, ...
At greater dilutions the indirect Coombs test is negative. If a few weeks later the same patient had an indirect Coombs titer ... This means that the patient's serum gives a positive indirect Coombs test at any dilution down to 1/16 (1 part serum to 15 ... For example, the indirect Coombs test detects the presence of anti-Rh antibodies in a pregnant woman's blood serum. A patient ... Many traditional serological tests such as hemagglutination or complement fixation employ this principle. Such tests can ...
... the Coombs test, also known as the antiglobulin test, is performed. There are two types of Coombs tests, direct and indirect; ... a direct antiglobulin test (DAT)(also known as a Coomb's test) is done to show auto-immune pathogenesis with antibodies, ... Of these developments, the antiglobulin test described by Coombs, Mourant, and Race in 1945 has proved to be one of the more ... The test was premature and was forgotten. In 1946, Boorman, Dodd, and Loutit applied the direct antiglobulin test to a variety ...
Drug Testing: Issues and Options, with Robert H. Coombs, eds. New York: Oxford University Press (Apr. 1991). ISBN 978- ...
It is essentially an indirect Coomb's test. It is also called "full cross-matching", "IAT cross-matching" and "Coomb's cross- ... Cross-matching or crossmatching is a test performed before a blood transfusion as part of blood compatibility testing. Normally ... where a donor's blood is tested prior to donation) and testing done on blood samples from the intended recipient. This includes ... It is an immediate test that involves combining the patient's serum and donor's red blood cells at room temperature, then ...
... a test for the presence of antibodies or antigens Coombs reagent, the reagent used in the Coombs test Coombs' method, a type of ... Coombs is a surname. Coombs may also refer to: Coombs, British Columbia, a small community in British Columbia, Canada Coombs ... Lake, a lake in Minnesota Coombs test, ... page lists articles associated with the title Coombs. If an ... voting designed by the psychologist Clyde Coombs Coombes, a village and civil parish in the Adur District of West Sussex, ...
The attachment of M. haemofelis to red blood cell membranes is often associated with positive Coombs test results, meaning IgG ... Additional clinical findings may include positive Coombs test results, hypoglycemia and dehydration. Antibiotic treatment is ... There is not yet available test that can confirm or deny the presence of infection in the body. Negative PCR doesn't always ... Currently, no serological test for M. haemofelis is commercially available. ...
... in cases of direct Coombs test, DCT, positive haemolytic anaemia). Platelet counts may be reduced, increased or normal. ...
A Coomb's test should be performed, and end-tidal carbon monoxide concentration should be monitored to understand the rate of ... Herschel M, Karrison T, Wen M, Caldarelli L, Baron B (2002-07-01). "Evaluation of the direct antiglobulin (Coombs') test for ... Results from the urine test should be confirmed by a complete blood count (CBC) and serum testing for total serum bilirubin and ... and positive Coombs test. Clinically, jaundice or dark urine present in approximately one-third of the cases, and most of the ...
... a test for the free hemoglobin binding protein haptoglobin, and the direct Coombs test (also called direct antiglobulin test or ... A positive Coombs test is a relative contraindication to transfuse the patient. In cold hemolytic anemia there is advantage in ... Laboratory studies commonly used to investigate hemolytic anemia include blood tests for breakdown products of red blood cells ...
MAR test in its original version is based on the classical Coombs test; sperm is mixed with human red blood cells coated with ... Since the test is performed with fresh semen and the incubation requires only 10 minutes, it renders MAR test a quick and ... These antibodies might be proved by the postcoital test (PCT). Although the test has been declared obsolete by some authors, it ... However, only Mixed Antiglobulin Reaction (MAR) test and Immunobead Test (IBT) are currently being recommended by the WHO for ...
Ackerman, D. L. (1991). A history of drug testing. In R. H. Coombs & L. J. West (Eds.), Drug testing: Issues and options (pp. 3 ... Lockheed test pilot Bob Ridenhauer survives with serious injuries and retires from test flying. He has to be cut out of the ... Forensic testing conducted found that several members of the deceased flight deck crew tested positive for marijuana (the ... 16 December McDonnell-Douglas F-15D-37-MC Eagle, 84-0042, c/n 0909/D050, of the 3246th Test Wing, Armament Development and Test ...
... if tested for reducing substances) and false positive Coombs test. Cefaclor has also been reported to cause a serum sickness- ... necessitates more frequent testing of INR, and dose adjustment as necessary.[citation needed] Excretion of cephalosporins is ...
Robin Coombs, A.E. Mourant and R.R. Race published a description of the antiglobulin test (also known as the Coombs test). ... A direct antiglobulin test (Coombs test) is also performed as part of the antibody investigation. Donor blood is generally ... If routine serologic testing for RhD results in a score of 2+ or less, the antiglobulin test can be used to demonstrate the ... The indirect antiglobulin test, which is used for weak D testing and typing of some red blood cell antigens, detects IgG bound ...
An antiglobulin test, also known as a Coombs test, is a type of blood test used in immunohematology. An antiglobulin test may ... Both direct and indirect Coombs tests may be useful for investigating suspected blood transfusion reactions. The indirect test ... either be direct (e.g., "direct antiglobulin test" or "direct Coombs test"), or indirect. The direct test is designed to detect ... In an elution test, the eluted antibodies are subsequently tested against a panel of reagent red blood cells of known phenotype ...
Diagnosis is made by a positive direct Coombs test, other lab tests, and clinical examination and history. The direct Coombs ... test looks for antibodies attached to the surface of red blood cells.[citation needed] Laboratory findings include severe ...
A direct antiglobulin test (Coombs test) is also performed as part of the antibody investigation. If there is no antibody ... Agglutination or hemolysis (i.e., positive Coombs test) in the test tube is a positive reaction and the unit should not be ... In the immediate spin method, two drops of patient serum are tested against a drop of 3-5% suspension of donor cells in a test ... Prior testing of donor blood only included testing for antibodies to HIV. However, because of latent infection (the "window ...
A direct Coombs test may also be used, but does have a high rate of false negatives. Crossmatching using saline agglutination ... Currently, screening tests of colostrum for use in the field have not been found to be accurate. The severity of clinical signs ... Such tests include crossmatching the mare's serum to washed red blood cells of the foal, which is added to exogenous complement ... If a non-compatible stallion is used, the mare's serum should be tested for alloantibodies in the final month of gestation. ...
An antiglobulin test (called the Coombs test) may be performed to determine the presence of a specific type of antibody. In ... Detection of antibodies (cold or warm) and /or complement system on RBC from the patient is a direct Coombs antiglobulin test. ... is an indirect Coombs antiglobulin test.[citation needed] A diagnosis of cold agglutinin disease may be made after several ... the Coombs test is almost always positive for immunoglobulin M (IgM). Avoid cold weather. Treat the underlying lymphoma. No ...
Hematologic: Hemolytic anemia (direct Coombs test is positive) and various cytopenias, and bleeding (caused by thrombocytopenia ... The monospot test is not recommended for general use by the CDC due to its poor accuracy. Serologic tests detect antibodies ... The Paul-Bunnell Test or PBT was later replaced by the heterophile antibody test. The Epstein-Barr virus was first identified ... The heterophile antibody test is a screening test that gives results within a day, but has significantly less than full ...
... "direct antiglobulin test" (Coombs' test) - this should be negative, as hemolysis in G6PD is not immune-mediated; When there are ... "Beutler fluorescent spot test", which has largely replaced an older test (the Motulsky dye-decolouration test). Other ... Diagnosis is based on symptoms and supported by blood tests and genetic testing. Affected persons must avoid dietary triggers, ... which can be confirmed with the other tests.[citation needed] Testing during and for many weeks after a haemolytic episode will ...
The first, and most well recognized Test Family were the Coombs, who were the Test Family for three years.[citation needed] ... Every week the Target test family test a chosen product. In this test about 5 brands of a particular product are tested by the ... Food items are usually taken to a lab to run other tests on the product as well. The test family are used for most product ... The test is not only to see the standard of the work carried out but also the actions of the worker, whether he/she wanders ...
The Coombs test is also used for antibody screening in blood transfusion preparation and also for antibody screening in ... Animal toxicity studies: Acute toxicity testing, repeat-dose toxicity testing, long-term toxicity testing Pharmacokinetics and ... An extreme example is the clumping, or agglutination, of red blood cells with antibodies in the Coombs test to determine blood ... in vitro and in vivo testing for adventitious viruses, murine retrovirus testing..., product safety data needed before the ...
If clumping is seen, the Coombs test is positive; if not, the Coombs test is negative. Common clinical uses of the Coombs test ... The indirect Coombs test is used in prenatal testing of pregnant women and in testing prior to a blood transfusion. The test ... also known as Coombs antiglobulin or antihuman globulin) is used in both the direct Coombs test and the indirect Coombs test. ... Coombs test- Medlineplus.org. Drugs that cause haemolytic anemia - Merck Manual. Coombs+Test at the U.S. National Library of ...
The Coombs test looks for antibodies that may stick to your red blood cells and cause red blood cells to die too early. ... The Coombs test looks for antibodies that may stick to your red blood cells and cause red blood cells to die too early. ... The Coombs test looks for antibodies that may stick to your red blood cells and cause red blood cells to die too early. ... The direct Coombs test is used to detect antibodies that are stuck to the surface of red blood cells. Many diseases and drugs ...
Coombs test: Rarely positive Computed tomography. Body CT scanning is important for initial staging and for assessing the ... Hyper-CVAD with or without rituximab followed by ASCT was tested at the M.D. Anderson Cancer Center as a frontline regimen. It ... Which tests are used to diagnose and stage mantle cell lymphoma (MCL)? ... What is the role of lab tests in the workup of mantle cell lymphoma (MCL)? ...
A direct Coombs test determines the ability of anti-IgG antisera to agglutinate the patients RBCs. In the indirect Coombs test ... The Coombs test can help diagnose autoimmune hemolysis. ... Perform this test for a pregnant patient with acute anemia and ... Serum iron testing measures the amount of iron bound to transferrin. The reference range is 50-150 µg/dL. The serum ferritin ... This test should always be correlated with normally functioning platelet levels, but very low platelet counts can prolong the ...
Interaction with diagnostic tests In patients treated with Renapime positive Coombs test was described with no evidence of ... Interference with serological testing A positive Coombs test, without evidence of haemolysis, has been described in patients ... During clinical tests, changes in laboratory tests were transient in the patients with normal baseline values. The changes that ... and positive Coombs test with no haemolysis (18.7%). The transient increases of uraemia, serum creatinine and thrombocytopenia ...
... results of direct and indirect Coombs test, negative. ...
The GEL test is a reliable and rapid clinical laboratory method for identification of DEA 1.1. The MSU test requires Coombs ... Use of the CARD test allows for rapid identification of DEA 1.1 but may produce weak reactions with blood from DEA 1.2-positive ... The GEL test is a reliable and rapid clinical laboratory method for identification of DEA 1.1. The MSU test requires Coombs ... 1.1 reagents of the CARD and GEL tests as well as MSU test (only after adding Coombs reagent) in 9 blood samples. By use of ...
All 63 subjects enrolled in this study had a negative direct antiglobulin (Coombs) test at baseline. During the study, no ... 5.9 Monitoring Laboratory Tests 5.10 Interference with Laboratory Tests 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 ... Hematologic: Pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs) test.. *General/Body as a Whole: ... 5.9 Monitoring Laboratory Tests. *Periodic monitoring of renal function and urine output is particularly important in patients ...
Coombs test. Diagnostic test that can detect the presence of antibodies in the serum that react with antigens on the surface of ... Nucleic Acid Testing: RNA and DNA tests to detect infectious viral agents based on the amplification of nucleic acid fragments. ... Technique for pretransfusion tests based on the Ag-Ab reaction (antigens-antibodies), causing a given agglutination, which can ... It is used as an anticoagulant in tubes used to extract blood in some laboratory tests that measure blood clotting time, ...
... and the Coombs test. It is important to note that the Coombs test remains positive longer than other agglutination tests. ... CDC utilizes a test called the Brucella microagglutination test (BMAT), a modified version of the serum (tube) agglutination ... CDC recommends that Brucella serology testing only be performed using tests approved by the Food and Drug Administration (FDA ... Results from these tests should be considered supportive evidence for recent infection only and interpreted in the context of a ...
Tests of immune function/dysfunction. A Coombs test looks for antibodies directed against red blood cells. This test can ... Additionally, if the tests are abnormal, specific therapy may be indicated.. *Bone marrow aspirate. This test is performed to ... An anti-nuclear antibody test also evaluates for the presence of antibodies aimed at ones own cells and a positive test is ... Additional tests include:. *Complete blood count. The CBC evaluates the red and white blood cells, as well as the platelets. ...
A pioneer-his frontier was hidden in test tubes. Johnny Coombs. A prospector-he returned from the asteroids too soon. Merrill ... Test pilot-happy only when his life hung in the balance. Tom Hunter. ...
Direct antiglobulin test (DAT, direct Coombs test); Electronic crossmatch; Examination for blood group antibodies; Group checks ... Haematology - Haemostasis related analysis (including special coagulation testing and platelet function tests) Plasma Activated ... Chemical pathology - Tests for thyroid function Serum Thyroid stimulating hormone (TSH); Thyroxine (T4) - Free ... Infertility and pregnancy tests including assisted reproductive technology - Diagnosis or follow up of threatened abortion and/ ...
Coombs test is done to find certain antibodies (proteins generated by the bodys immune system) that attack red blood cells. ... Inform your doctor or lab technician regarding the use of Abifix 200 mg Tablet if you are undergoing the Coombs test. A false- ... A urine ketone test measures ketone levels in your urine. Inform your doctor or lab technician regarding the use of Abifix 200 ... A false-positive result may be obtained if this test is performed while taking this medicine. ...
LOINC Code 1008-2 Indirect antiglobulin test.polyspecific reagent [Presence] in Serum or Plasma ... 血库试验项目类 血库成分 - 抗球蛋白试验 血清或血浆 间接 Coomb 氏试验 间接 Coomb 试验 间接型 间接库姆氏试验 间接库姆氏试验(Indirect Coombs,. IDC,. Indirect Coombs Test,. ICT) 间接 ... Synonyms: Coombs indirect test. Polyspécifique. it-IT. Italian (Italy). Antiglobulina indiretta, test.reagente polispecifico:. ... Ind Coombs;. IDC;. IAGT
May result in false-negative aldosterone/renin ratio (ARR). May cause a positive direct Coombs test. ... May cause false-positive urine test for acetone determination using Na nitroprusside reagent. ...
It is also adapted for performing Coombs test and other cell washing procedures. Specifications Blood... ... Blood Type Test ABO RhD Blood Grouping Test Fast Results Health Rapid Test ABO and RhD Blood Grouping & Typing Rapid Tests, ... Blood Test Veterinary DW-36VET CBC Hematology Analyzer Hotspot 1. High quality spare parts 2. Large LCD touch screen 10.4" 3. ... blood grouping as well as various kinds of blood cell test instruments. It offers a comprehensive protection for blood cell, ...
Methyldopa has been associated with hemolytic anemia while a positive coombs test has been reported with methyldopa, ...
Positive Coombs tests are common. Most infected erythrocytes are removed by the reticuloendothelial system in the liver, lungs ... Positive serolog-ic test results occur in healthy cats as well as clinically ill cats and so a diagnosis of clinical ... Thus, the PCR is the test of choice due to sensitivity. Primers are available that detect a segment of the 16S rRNA gene common ... A tentative diagnosis of feline clinical ehrlichiosis can be based on the combination of positive serologic test results, ...
Evans syndrome is the coexistence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) with ... Teachey et al screened 12 children by using flow cytometry for CD4/CD8 (double-negative) T cells and using the definitive test ... Evans syndrome is the presence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) in ... Evans syndrome is the coexistence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) with ...
LISS/Coombs, Coombs Anti-IgG, DiaScreen, LISS/Coombs + Enzyme Test, DiaClon Type + Screen. Advice regarding the use of the ... Accu-Chek® Inform II blood glucose test strips, Accu-Chek Aviva blood glucose test strips - FSN 1. Accu-Chek® Inform II blood ... glucose test strips, Accu-Chek Aviva blood glucose test strips - FSN 2. Advice regarding a device removal. HPRA Ref: V35746. ...
Coombs tests. (−). Folate. 5.3 mg/dL. MCV=mean corpuscular volume; APTT=activated partial thromboplastin; BUN=blood urea ... Coagulation test. Brucella Agglutination. (−). Glucose. 142 mg/dL. Prothrombin time. 19.2 sec. Syphilis. (−). CRP. 20.93 mg/dL ... antinuclear antibody test ; IgG, A, M=immunoglobulin G, A, M; C3, 4=Complement 3, 4; ESR=erythrocyte sedimentation rate ...
Δ TSB was negative in non-Blacks, in infants with positive direct Coombs test (DC+) or those receiving phototherapy. Black race ... Furthermore, testing for RASopathies should be recommended especially in presence of increased nuchal translucency thickness ...
Direct Antiglobulin (Direct Coombs) Test. The direct Coombs test is used to determine whether red blood cell (RBC)-binding ... Indirect Antiglobulin (Indirect Coombs) Test. The indirect Coombs test is used to detect IgG antibodies against red blood cells ... Most hemolytic anemias cause abnormalities in one of these variables, and so test results can direct further testing. ... The peripheral smear and reticulocyte count are the most important tests to diagnose hemolysis. Antiglobulin testing or ...
... causing a positive direct antiglobulin test (DAT) (Coombs test) result and hemolysis.7-9 Delayed hemolytic anemia can develop ... Fab functions tested include antigen binding capacities, and Fc functions tested include complement activation and Fc-receptor- ... Lead to misinterpretation of the results of serological testing. (5.11). *Interfere with the response to live virus vaccines. ( ... Consider appropriate laboratory testing in higher risk patients, including measurement of hemoglobin or hematocrit prior to ...
thrombocytopenia, positive direct Coombs test, high titer of antinuclear and anti-dsDNAantibodies, low levels of C3 and C4 ...
Public Health Service Recommendations for Human Immunodeficiency Virus Counseling and Voluntary Testing for Pregnant Women ... Celum CL, Coombs RW, Jones JM, et al. Risk factors for repeatedly reactive HIV-1 EIA and indeterminate Western blots: a ... but testing is neither encouraged nor discouraged) (52). Laboratory Testing Considerations The HIV-1 testing algorithm ... HIV testing patterns: where, why and when were persons with AIDS tested for HIV? AIDS 1995;9:487-92. * El-Sadr W, Oleske JM, ...
ImportError running test on namespace package - other package in namespace not found by Jason R. Coombs 17 Apr 20 ... setup test in myprojectB, the tests fail with File .mymoduleZ.py, line NNN, in [some context] from mynamespace.myprojectA. ... Is this a supported configuration? Is there something I can do to make tests work with interdependent projects with the same ... in my test case, it fails b/c it cannot find A in pipy - in this example, what happens if friend does not have net connection ...
Hemolysis in idiopathic TTP is mechanical and nonimmune mediated, thus Coombs testing is usually negative. Nowadays, autoimmune ... The laboratory tests showed a Direct antiglobulin test (+), indicating peripheral cytopenias, particularly autoimmune ... Coombs testing could be positive in that case, and usually ended with fatality in adult literature[7]. A variety of autoimmune ... On the 4th day post PEX, continuous improvement was noted on the blood test, with platelets peaked to 195×109/L and LDH down to ...
  • The patient's RBCs are washed (removing the patient's own serum) and then centrifuged with antihuman globulin (also known as Coombs reagent). (wikipedia.org)
  • Strong RBC agglutination reactions were observed with dog erythrocyte antigen (DEA) 1.1 reagents of the CARD and GEL tests as well as MSU test (only after adding Coombs' reagent) in 9 blood samples. (nih.gov)
  • All blood samples agglutinated with the B antigen reagent of the TUBE test. (nih.gov)
  • All but 2 blood samples had strong positive reactions with the DEA 4 reagent of the MSU test. (nih.gov)
  • All but 3 blood samples reacted with the E antigen reagent of the TUBE test. (nih.gov)
  • Three blood samples agglutinated with the DEA 3 reagent of the MSU test and A antigen reagent of the TUBE test. (nih.gov)
  • Five blood samples had strong agglutination reactions with the DEA 5 reagent of the MSU test. (nih.gov)
  • The MSU test requires Coombs' reagent for identification of DEA 1.1 and 1.2. (nih.gov)
  • The direct and indirect Coombs tests, also known as antiglobulin test (AGT), are blood tests used in immunohematology. (wikipedia.org)
  • citation needed] The direct Coombs test, also referred to as the direct antiglobulin test (DAT), is used to detect if antibodies or complement system factors have bound to RBCs surface antigens. (wikipedia.org)
  • citation needed] The indirect Coombs test, also referred to as the indirect antiglobulin test (IAT), is used to detect in-vitro antibody-antigen reactions. (wikipedia.org)
  • Previous case reports have described patients with COVID-19-associated autoimmune hemolytic anemia (AIHA), and cold agglutinin disease (CAD) which is characterized by a positive direct antiglobulin (DAT) or "Coombs" test, yet the mechanism is not well understood. (gob.pe)
  • The direct Coombs test is used to test for autoimmune hemolytic anemia, a condition where the immune system breaks down red blood cells, leading to anemia. (wikipedia.org)
  • Evans syndrome is the coexistence of simultaneous or sequential direct Coombs-positive autoimmune hemolytic anemia (AIHA) with immune-mediated thrombocytopenia. (medscape.com)
  • The direct Coombs test detects antibodies that are stuck to the surface of the red blood cells. (wikipedia.org)
  • The indirect Coombs test detects antibodies that are floating freely in the blood. (wikipedia.org)
  • The direct Coombs test is used to detect antibodies or complement proteins attached to the surface of red blood cells. (wikipedia.org)
  • If the red cells then agglutinate, the test is positive, a visual indication that antibodies or complement proteins are bound to the surface of red blood cells and may be causing destruction of those cells. (wikipedia.org)
  • The test detects antibodies against foreign red blood cells. (wikipedia.org)
  • The two Coombs tests are based on anti-human antibodies binding to human antibodies, commonly IgG or IgM. (wikipedia.org)
  • Common clinical uses of the Coombs test include the preparation of blood for transfusion in cross-matching, atypical antibodies in the blood plasma of pregnant women as part of antenatal care, and detection of antibodies for the diagnosis of immune-mediated hemolytic anemias. (wikipedia.org)
  • citation needed] The indirect Coombs test is used to screen for antibodies in the preparation of blood for blood transfusion. (wikipedia.org)
  • The Coombs test looks for antibodies that may stick to your red blood cells and cause red blood cells to die too early. (medlineplus.gov)
  • An abnormal (positive) direct Coombs test means you have antibodies that act against your red blood cells. (medlineplus.gov)
  • CDC utilizes a test called the Brucella microagglutination test (BMAT), a modified version of the serum (tube) agglutination test (SAT), that can detect antibodies to Brucella species - abortus , melitensis or suis . (cdc.gov)
  • There is no serological test available to detect antibodies to B. canis . (cdc.gov)
  • The serum (tube) agglutination test (SAT) detects antibodies to the S-LPS. (cdc.gov)
  • Antibodies reacting against S-LPS can also be detected by other tests, such as ELISA (enzyme-linked immunosorbent assay) and the Coombs test. (cdc.gov)
  • CDC recommends that Brucella serology testing only be performed using tests approved by the Food and Drug Administration (FDA), or validated under the Clinical Laboratory Improvement Amendments (CLIA) and shown to reliably detect the presence of Brucella antibodies. (cdc.gov)
  • Technique for pretransfusion tests based on the Ag-Ab reaction (antigens-antibodies), causing a given agglutination, which can then be observed to determine the blood type. (grifols.com)
  • Positive serolog-ic test results occur in healthy cats as well as clinically ill cats and so a diagnosis of clinical ehrlichiosis should not be based on serologic test results alone. (vin.com)
  • A tentative diagnosis of feline clinical ehrlichiosis can be based on the combination of positive serologic test results, clinical signs of disease consistent with Ehrlichia infection, exclusion of other causes of the disease syndrome, and response to anti-rickettsial drugs. (vin.com)
  • For diagnosis, laboratory tests and invasive procedures are utilized, depending on the system affected. (lecturio.com)
  • The cold agglutinin titer was examined in 22 patients due to symptoms suggestive of cold agglutinin disease, and all tested negative. (gob.pe)
  • Laboratory findings revealed leukopenia, hypochromic microcytic anemia, thrombocytopenia, positive direct Coombs' test, high titer of antinuclear and anti-dsDNAantibodies, low levels of C3 and C4 suggestive for SLE flare. (ispub.com)
  • Coombs tests are performed using RBCs or serum (direct or indirect, respectively) from venous whole blood samples which are taken from patients by venipuncture. (wikipedia.org)
  • Female patients of childbearing potential must have a negative serum pregnancy test result within 7 days prior to initiation of crovalimab. (who.int)
  • We demonstrated a significant association with reactive Coombs test results in univariate analysis through clinical findings such as ICU admission rate, the severity of COVID-19, and several laboratory findings such as CRP, D-dimer, and hemoglobin levels lactate dehydrogenase, and RDW-CV. (gob.pe)
  • The direct Coombs test is used clinically when immune-mediated hemolytic anemia (antibody-mediated destruction of RBCs) is suspected. (wikipedia.org)
  • If immunoglobulin or complement factors have been fixed on to the RBC surface in-vitro, the antihuman globulin will agglutinate the RBCs and the direct Coombs test will be positive. (wikipedia.org)
  • A visual representation of a positive direct Coombs test is shown in the upper half of the schematic). (wikipedia.org)
  • results of direct and indirect Coombs test, negative. (cdc.gov)
  • if not, the Coombs test is negative. (wikipedia.org)
  • There were 27 (20%) patients in the Coombs-positive group and 108 (80%) in the Coombs-negative group. (gob.pe)
  • In the appropriate test tube conditions, this can lead to agglutination of RBCs and allowing for visualisation of the resulting clumps of RBCs. (wikipedia.org)
  • A positive Coombs test indicates that an immune mechanism is attacking the patient's RBCs. (wikipedia.org)
  • A possible explanation of COVID-19-associated positive Coombs is cytokine storm-induced hyperinflammation, complement system activation, alterations of RBCs, binding of SARS-CoV-2 proteins to hemoglobin or its metabolites, and autoantibody production. (gob.pe)
  • Coombs-positive patients were tested for hemolysis using indirect bilirubin, consumed haptoglobin, and/or peripheral smear that ruled out any evidence of hemolysis. (gob.pe)
  • The bilirubin blood test measures the level of bilirubin in the blood. (limamemorial.org)
  • The clinical significance of the result is assessed by the physician who requested the Coombs test, perhaps with assistance from a laboratory-based hematologist. (wikipedia.org)
  • The GEL test is a reliable and rapid clinical laboratory method for identification of DEA 1.1. (nih.gov)
  • Blood collection Tube EDTA tube is widely used in clinical haematology, cross matching, blood grouping as well as various kinds of blood cell test instruments. (chinaqualitycrafts.com)
  • Given the high prevalence of allergies in this patient population and their unclear clinical relevance, Dr. Eichenfield emphasized the importance of patient selection when considering allergy testing. (medscape.com)
  • The DAT is not required for pre-transfusion testing but may be carried out by some laboratories. (wikipedia.org)
  • Results from these tests should be considered supportive evidence for recent infection only and interpreted in the context of a clinically compatible illness and exposure history. (cdc.gov)
  • In addition to bacterial isolation, serological tests can be performed. (cdc.gov)
  • To investigate the significance of Coombs test reactivity among COVID-19 patients, we conducted a retrospective study on hospitalized COVID-19 patients treated at NMC Royal Hospital between 15 April and 30 May 2020. (gob.pe)
  • There were flaws in the recording of information, the most serious being related to laboratory tests and nutritional evaluation of the pregnant woman. (bvsalud.org)
  • Your health care provider may recommend this test if you have signs or symptoms of anemia or jaundice (yellowing of the skin or eyes). (medlineplus.gov)
  • Although platelet count of 46 000/mm3 (repeat test in the mothers may have nonspecific febrile another sample was 34 000/mm3). (who.int)
  • Talk to your provider about the meaning of your specific test results. (medlineplus.gov)
  • To compare canine blood-typing results determined by use of the card (CARD), gel (GEL), Michigan State University (MSU), and tube (TUBE) tests. (nih.gov)
  • on the basis of MSU test results, these 4 dogs were classified as DEA 1.2 positive. (nih.gov)
  • The indirect Coombs test is used in prenatal testing of pregnant women and in testing prior to a blood transfusion. (wikipedia.org)
  • The following persons either served as consultants at the workshop for developing the recommendations for HIV counseling and voluntary testing for pregnant women or were members of the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immunodeficiency Virus. (cdc.gov)
  • This document recommends routine HIV counseling and voluntary testing for all pregnant women and is intended to serve as guidance for health-care providers in educating women about the importance of knowing their HIV infection status. (cdc.gov)
  • The IAT can also be used for compatibility testing, antibody identification, RBC phenotyping, and titration studies. (wikipedia.org)
  • The test result may also be abnormal without any clear cause, especially among the older people. (medlineplus.gov)
  • Cases were investigated by tube agglutination test (TAT) and 2-mercaptoethanol test (2-MET) and a ques- tionnaire was completed for each. (who.int)
  • the test can be carried out to diagnose reactions to a blood transfusion. (wikipedia.org)
  • Use of the CARD test allows for rapid identification of DEA 1.1 but may produce weak reactions with blood from DEA 1.2-positive dogs. (nih.gov)
  • It is widely used in performing serological test in hospitals and research institutes. (chinaqualitycrafts.com)
  • Allergy testing, which may include radioallergosorbent testing and/or referral to an allergist, may be useful when patients are difficult to control or maintain with standard therapy or when an allergy is suspected on the basis of a patient's history and pattern of flares. (medscape.com)
  • Therefore, especially with re- gard to respiratory allergy, standardized and validated dose-response test methods are urgently required in order to be able to recommend safe exposure levels for allergens at the workplace. (cdc.gov)
  • clarification needed] Before transfusion, an indirect Coombs test is often done. (wikipedia.org)
  • This test is most often done to determine if you may have a reaction to a blood transfusion. (medlineplus.gov)
  • In addition, the observed dose-response relationships and threshold values have been obtained by a wide variety of test methods using different techniques, such as intradermal exposure versus topical or inhalation exposure at the workplace, or using different endpoints, which all appear important for the outcome of the test. (cdc.gov)
  • Some labs use different measurements or test different samples. (medlineplus.gov)
  • It is important to note that the Coombs test remains positive longer than other agglutination tests. (cdc.gov)