DiseasesChemicals and Drugs
ConvulsantsFlurothylEthosuximidePentylenetetrazoleStrychninePicrotoxinBicucullineSeizuresAnticonvulsants
Convulsants
Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.
Flurothyl
A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.
Ethosuximide
An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Pentylenetetrazole
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
Strychnine
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
Picrotoxin
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Bicuculline
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity.

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (1/415)

The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity.  (+info)

Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives. (2/415)

A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate.  (+info)

Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. (3/415)

CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at least two GABA binding sites, a higher-affinity site (EC50-1 = 11.0 microM) and a lower-affinity site (EC50-2 = 334.2 microM), on two or more populations of cells. The effects of GABAR allosteric modulators on peak concentration-dependent GABAR currents were complex and included monophasic (loreclezole) or multiphasic (diazepam) enhancement, mixed enhancement/inhibition (DMCM, zolpidem) or multiphasic inhibition (zinc). Monophasic (70% of cells) or biphasic (30% of cells) enhancement of GABAR currents by diazepam suggested three different sites on GABARs (EC50-1 =1.8 nM; EC50-2 = 75.8 nM; EC50-3 = 275.9 nM) revealing GABAR heterogeneity. The imidazopyridine zolpidem enhanced GABAR currents in 70% of cells with an EC50 = 222.5 nM, suggesting a predominance of moderate affinity alpha2 (or alpha3-) subtype-containing BZ Type IIA receptors. A small fraction of cells (10%) had a high affinity for zolpidem, something that is suggestive of alpha1 subtype-containing BZ Type I receptors. The remaining 30% of cells were insensitive to or inhibited by zolpidem, suggesting the presence of alpha5 subtype-containing BZ Type IIB receptors. Whether BZ Type I and Type II receptors coexist could not be determined. The beta-carboline methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) inhibited GABAR currents in all cells at midnanomolar concentrations, but in addition, potentiated GABAR currents in some cells at low nanomolar concentrations, characterizing two groups of cells, the latter likely due to functional assembly of alpha5betaxgamma2GABARs. In all cells, GABAR currents were moderately sensitive (EC50 = 9 microM) to loreclezole, consistent with a relatively greater beta3 subtype, than beta1 subtype, subunit mRNA expression. Two populations of cells were identified based on their sensitivities to zinc(IC50 = 28 and 182 microM), suggesting the presence of at least two GABAR isoforms including alpha5beta3gamma2 GABARs. Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABAR isoforms.  (+info)

Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. (4/415)

To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1.  (+info)

Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. (5/415)

Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in human temporal lobe epilepsy and rodent epilepsy models. Whether this plasticity results from the remodeling of preexisting mossy fibers or instead reflects an abnormality of developing dentate granule cells is unknown. Because these neurons continue to be generated in the adult rodent and their production increases after seizures, mossy fibers that arise from either developing or mature granule cells are potential substrates for this network plasticity. Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats. A single dose of 5 Gy irradiation blocked cell proliferation and eliminated putative progenitor cells in the dentate subgranular proliferative zone. Irradiation 1 d before pilocarpine-induced status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures. Two irradiations, 1 d before and 4 d after status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent mossy fiber reorganization in the dentate molecular layer. These results indicate that dentate granule cell neurogenesis in the mature hippocampal formation is vulnerable to the effects of low-dose ionizing irradiation. Furthermore, the development of aberrant mossy fiber remodeling in the absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizure-induced network reorganization.  (+info)

Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. (6/415)

BACKGROUND: Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the anesthetic action of barbiturates. The authors compared the effects of depressant [R(-)] and convulsant [S(+)] stereoisomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on the AMPA and gamma-aminobutyric acid type A (GABA(A)) receptor-mediated currents to determine if the inhibitory effects on AMPA receptors correlate to the in vivo effects of the isomers. METHOD: The authors measured whole-cell currents in the rat cultured cortical neuron at holding potential of -60 mV. Kainate 500 microM was applied as the agonist for AMPA receptors. Thiopental (3-300 microM), R(-)-MPPB or S(+)-MPPB (100-1,000 microM) was coapplied with kainate under the condition in which the GABA(A) receptor-mediated current was blocked. Effects of MPPB isomers on the current elicited by GABA 1 microM were studied in the separate experiments. RESULTS: Thiopental inhibited the kainate-induced current reversibly and in a dose-dependent manner, with a concentration for 50% inhibition of 49.3 microM. Both R(-)-MPPB and S(+)-MPPB inhibited the kainate-induced current with a little stereoselectivity. R(-)-MPPB was slightly but significantly more potent than S(+)-MPPB. In contrast, R(-)-MPPB enhanced but S(+)-MPPB reduced the GABA-induced current. CONCLUSIONS: Both convulsant and depressant stereoisomers of the barbiturate inhibited the AMPA receptor-mediated current despite of their opposite effects on the central nervous system in vivo. Although thiopental exhibited a considerable inhibition of AMPA receptors, the results suggest that the inhibition of AMPA receptors contributes little to the hypnotic action of the barbiturates.  (+info)

Analytical detection and quantitation of strychnine in chemically fixed organ tissues. (7/415)

This study reports the results of the detection and quantitation of strychnine in formalin-fixed tissues and in the formalin solutions in which the tissues were fixed. The toxicological analyses were performed on formalin-fixed liver and kidney samples and formalin solutions (10% buffered pH 7) in which the same samples from a case of acute strychnine poisoning were preserved. The analyses carried out at the time of autopsy on body fluid and tissues (bile, 2.40 mg/L; stomach contents, 14.2 mg; liver, 6.68 mg/kg; kidney, 2.68 mg/kg) allowed the identification of this substance as cause of death. The tissue samples were preserved in formalin solutions for 8 weeks. The analyses performed on formalin-fixed tissues (liver and kidney) and on formalin solutions, in which the same tissues were preserved, permitted the detection and quantitation of strychnine (liver, 1.59 mg/kg; formalin from the liver, 1.80 mg/L; kidney, 0.98 mg/kg; formalin from the kidney, 1.11 mg/L). The results indicate that this particular toxic substance also shows good stability in biological specimens subjected to chemical fixation.  (+info)

GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. (8/415)

gamma-Aminobutyric acid (GABA)-activated channels in embryonic (5-8 wk old) human dorsal root ganglion (DRG) neurons in dissociated culture were characterized by whole cell and single-channel techniques. All DRG neurons when held at negative holding membrane potentials displayed inward current to micromolar concentrations of GABA applied by pressure pulses from closely positioned micropipettes. The current was directly proportional to the concentration of GABA (EC50, 111 microM; Hill coefficient, 1.7). DRG neurons also responded to micromolar concentrations of pentobarbital and alphaxalone but not to cis-4-aminocrotonic acid (CACA), glycine, or taurine. Baclofen (100 microM) affected neither the holding currents nor K+ conductance (when patch pipettes were filled with 130 mM KCl) caused by depolarizing pulses. Whole cell GABA-currents were blocked by bicuculline, picrotoxin, and t-butylbicyclophosphorothionate (TBPS; all at 100 microM). The reversal potential of whole cell GABA-currents was close to the theoretical Cl- equilibrium potential, shifting with changes in intracellular Cl- concentration in a manner expected for Cl--selective channels. The whole cell I-V curve for GABA-induced currents demonstrated slight outward rectification with nearly symmetrical outside and inside Cl- concentrations. Spectral analysis of GABA-induced membrane current fluctuations showed that the kinetic components were best fitted by a triple Lorentzian function. The apparent elementary conductance for GABA-activated Cl- channels determined from the power spectra was 22.6 pS. Single-channel recordings from cell-attached patches with pipettes containing 10 microM GABA indicated that GABA-activated channels have a main and a subconductance level with values of 30 and 19 pS, respectively. Mean open and closed times of the channel were characterized by two or three exponential decay functions, suggesting two or three open channel states and two closed states. Single channels showed a lack of rectification. The actions of GABA on cultured human embryonic DRG neurons are mediated through the activation of GABAA receptors with properties corresponding to those found in the CNS of human and other mammalian species but differing from those of cultured human adult DRG neurons.  (+info)

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Welcome to MPPB | Department of Molecular Pharmacology, Physiology, and BiotechnologyWelcome to MPPB | Department of Molecular Pharmacology, Physiology, and Biotechnology
MPPB faculty offer extensive experience in biotechnology and in the biomedical device industry, with research interests spanning from molecules to cells, tissues to organs to whole organisms.. Grounded in a base of chemistry, physics, math, and biology, MPPB is a basic-science department within Brown Alpert Medical School, and a full participant in the undergraduate-based Program in Biology within the Division of Biology and Medicine.. Within the Medical School, the departments educational mission is to provide medical students and MD/PhD candidates with a solid foundation in basic science and to help prepare them for a lifetime of learning and problem solving.. MPPB supports graduate and postdoctoral education by providing a highly interdisciplinary framework for individual and thematic training programs both classical and newly emerging. Brown also provides state-of-the-art equipment and resources through its Shared Resource Facilities.. Areas of study include molecular and structural ...
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Proper Timing of Vaccinations to Help Develop the Best Immunity | Beef MagazineProper Timing of Vaccinations to Help Develop the Best Immunity | Beef Magazine
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AID 772070 - Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in albino mouse assessed as...AID 772070 - Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in albino mouse assessed as...
BioAssay record AID 772070 submitted by ChEMBL: Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in albino mouse assessed as duration of seizure time at 100 mg/kg, ip after 0.5 hr.
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Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. - Semantic ScholarCyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. - Semantic Scholar
Cyclooxygenases (COXs) are rate-limiting enzymes in the metabolic pathways in which arachidonic acid is converted to prostaglandins. COX-2 is the isoform induced at injury/inflammation sites and expressed constitutively in a few tissues, such as the central nervous system, and plays a role in neurodegenerative diseases associated with increased excitatory activity. However, the role of COX-2 and its main product, prostaglandin E(2) (PGE(2)), in the convulsive states is not fully established. In this study we showed that the selective COX-2 inhibitor, celecoxib (at the dose of 2mg/kg, but not at the doses of 0.2 or 20mg/kg, p.o.), protects against the seizures induced by pentylenetetrazol (PTZ, 60 mg/kg, i.p.). The role of PGE(2) in the convulsions induced by PTZ was further investigated by administering anti-PGE(2) antibodies (4 microg/2 microl, i.c.v.), and assessing electroencephalographic changes induced by PTZ (PTZ, 60 mg/kg, i.p.). Anti-PGE(2) antibodies attenuated PTZ-induced seizures in rats. In
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Publications - Core B Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice Pressly B. Vasylieva N. Barnych B, Singh V. Bruun DA, Hwang SH. Chen YJ, Johnnides S, Lein PJ. Yang J, Hammock BD, Wulff H Archives in Toxicology 2020 June:9494(6):1995-2007. PMID: 32239239
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Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...
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The central nervous system effects of a convulsant barbiturate, sodium 5-ethyl-5-(1,3-dimethylbutyl) barbiturate, were compared with the actions of pentobarbital in cats. Depending upon the dose, the convulsant barbiturate has both stimulant and depressant properties.. Under special conditions the convulsant barbiturate was shown to increase the mean convulsant dose of a timed intravenous infusion of pentylenetetrazole. Comparable amounts of pentobarbital were much more effective in increasing the mean convulsant dose of pentylenetetrazole. The depressant actions of the convulsant barbiturate appear to be real and not secondary to the stimulant effects.. The low to medium-voltage, medium to fast-frequency pattern observed in the EEG with the convulsant barbiturate was still present in three of five mesencephalic preparations verified by autopsy to be complete transections. In the remaining two preparations the convulsant barbiturate reduced the frequency of spindle bursts and prolonged the ...
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Inbred mouse strains have been shown to vary considerably in neurobehavioral testing. In the September 26 Proceedings of the National Academy of Science, Sandberg et al. describe the first use of DNA microarrays to determine the genetics events that might explain these phenotypic differences (Proc Natl Acad Sci USA 2000, 97:11038-11043). They compared two common inbred mouse strains (C57BL/6 and 129SvEv) by examining the expression profiles of over 10,000 genes in six different brain regions. They identified 24 genes that were differentially expressed in all brain regions of C57BL/6 animals compared with 129Sv/Ev. Furthermore, 1% of genes were differentially expressed in at least one brain region between the two strains. When comparing pentylenetetrazol-induced seizures, the immediate-early responses were similar but the overall transcriptional response was blunted in the 129SvEv strain. Sandberg et al. also found several genes that were enriched in one brain region, with the greatest ...
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Behavioral and metabolic features of repetitive seizures in immature and mature rats<...
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The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
https://www.komp.org/geneinfo.php?geneid=80851
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PDF] Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors...PDF] Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors...
Background Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8). Opipramole (10, 20, and 50 mg/kg), ketamine (50 mg/kg), caffeine (200 mg/kg), opipramole (20 mg/kg) plus ketamine (50 mg/kg), opipramole (20 mg/kg) plus caffeine (200 mg/kg), diazepam (5 mg/kg as a positive control), and the vehicle were administered interaperitoneally 30 minutes before the injection of PTZ. The latency was recorded for the clonic, tonic-clonic seizures, and death of animals after the injection of PTZ. Kruskal-Wallis test followed by Dunns test was used for the analysis of data. Statistical
https://www.semanticscholar.org/paper/Amelioration-of-Pentylenetetrazole-Induced-Seizures-Keshavarz-Yekzaman/6a44344b423215caee8bcd5d8d2b871fabf620ac
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish | Disease Models & MechanismsClosed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish | Disease Models & Mechanisms
Our results show that combining the hindbrain-activating properties of VNS with the reactive triggering of RNS results in a demand-triggered stimulation paradigm that might ultimately prove to have greater utility than either modality alone. Specifically, we showed that it was possible to use the changing statistical properties of the zebrafish cerebral field potential to trigger hindbrain stimulation in reaction to proconvulsant exposure in order to attenuate PTZ-induced seizures. These results implicate a potential role for reactive vagus nerve stimulation in the treatment of epilepsy. Given the large numbers of patients with implanted vagus nerve stimulators who continue to have seizures, further investigation into the possibility of a hybrid VNS-RNS stimulation platform is warranted.. Our results also suggest that the zebrafish cerebral field potential is of sufficient complexity to make it amenable to analysis by algorithms commonly used in the quest for seizure anticipation in human. ...
http://dmm.biologists.org/content/6/1/64
JCI - Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in...JCI - Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in...
Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized that leptin receptor activation in other neuronal subtypes would have anticonvulsant activity and that intranasal leptin delivery would be an effective route of administration. We tested leptins anticonvulsant action in 2 rodent seizure models by directly injecting it into the cortex or by administering it intranasally. Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels. These seizures were briefer and less frequent upon coinjection of 4-aminopyridine and leptin. In mice, intranasal administration of leptin produced elevated brain and serum leptin levels and delayed the onset of chemical convulsant pentylenetetrazole-induced generalized convulsive seizures. Leptin also reduced neuronal spiking in an in vitro seizure model. Leptin inhibited ...
https://www.jci.org/articles/view/33009/pdf
Yerba Mate Market Outlook 2021: Top Companies, Trends and Growth Factors Details by Regions, Types & Applications | Food and...Yerba Mate Market Outlook 2021: Top Companies, Trends and Growth Factors Details by Regions, Types & Applications | Food and...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Yerba Mate market provides detailed analysis of Market Overview, Market Drivers, Opportunities, Potential Application. Also Yerba Mate Market research report provides Emerging Market trends, Raw Materials Analysis, Manufacturing Process, regional outlook and comprehensive analysis on different market segments.. Yerba Mate industry drives A strong trend of R&D investments in Food & Beverages industries. Other growth drivers include the need to curtail costs, growth and increased use of shifting commodity prices, strength of private label brands and increased competition from players in Yerba Mate market.. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Yerba Mate Market Research [email protected] http://www.360marketupdates.com/10416903. Yerba Mate Market in World, presents critical information and factual data about Yerba Mate Industry, with an overall statistical study of this market on the ...
http://beforeitsnews.com/food-and-farming/2017/02/yerba-mate-market-outlook-2021-top-companies-trends-and-growth-factors-details-by-regions-types-applications-2497640.html
Pistachio Phenols 90% Bioavailable. Phe, Leu, Glu & Trp - Four Satiating Aminos. Artificial Sweeteners Act as Anti- Convulsants...Pistachio Phenols 90% Bioavailable. Phe, Leu, Glu & Trp - Four Satiating Aminos. Artificial Sweeteners Act as Anti- Convulsants...
When the gut tastes phenylalanine (PHE), leucine (LEU), glutamate (GLUT) and tryptophane (TRP), satiety ensues (Daly. 2012) -- In their most recent paper Christin Daly et al. report on the cholecystokinin (CCK) release in the gut. According to the scientists from the University of Liverpool (UK) and the Kyushu University (Japan), the effect is mediated by interactions with the gastrointestinal bitter taste receptors. Since CCK inhibits food intake and reduces appetite, this provides another mechanistic explanation for the satiety promoting effects of high protein intakes. The effects was observed only for the L- and not the D-amino acids ...
https://suppversity.blogspot.com/2012/12/pistachio-phenols-90-bioavailable-phe.html
Polycyclic organic compounds, Convulsants, Five-membered rings, Drugs acting on the gastrointestinal system and metabolism -...
Thujone ( ( listen)) is a ketone and a monoterpene that occurs naturally in two diastereomeric forms: (−)-α-thujone and (+)-β-thujone. It has a menthol odor. Though it is best known as a chemical compound in the spirit absinthe, which contains only small quantities of thujone, it is unlikely to be responsible for absinthes alleged psychedelic effects ...
http://api.chemchart.com/search?search=Polycyclic+organic+compounds%2C+Convulsants%2C+Five-membered+rings%2C+Drugs+acting+on+the+gastrointestinal+system+and+metabolism
View all posts in yerba mate
Health Benefits of Yerba Mate Yerba mate originated in South America and it is commonly known for its potency and ability to promote vitality, clarity, and well-being to those who drink it. It helps improve overall health and wellness and has numerous health benefits including a reduced risk of cardiovascular diseases and cancer. It naturally helps aid in weight loss and has antioxidant, antimicrobial, and anti-inflammatory properties. Nutritional Benefits Yerba mate tea is packed with essential nutrients that aid in maintaining good health. It is an excellent source of polyphenols, xanthines, caffeoyl derivatives and saponins. As well as a good source of vitamins […]. ...
http://blogs.natureshappiness.com/tag/yerba-mate/
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May 26, 2018 - Explore Liza Tobojkas board Yerba Mate, followed by 1247 people on Pinterest. See more ideas about yerba mate, yerba, mate.
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AID 131209 - Antagonism of Diazepam (2.5 mg/kg) anticonvulsant effects in mice treated with PTZ (80 mg/kg) - PubChemAID 131209 - Antagonism of Diazepam (2.5 mg/kg) anticonvulsant effects in mice treated with PTZ (80 mg/kg) - PubChem
BioAssay record AID 131209 submitted by ChEMBL: Antagonism of Diazepam (2.5 mg/kg) anticonvulsant effects in mice treated with PTZ (80 mg/kg).
https://pubchem.ncbi.nlm.nih.gov/bioassay/131209
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Antibiotics that lower seizure threshold - AbsInternationalEu
This article needs additional citations for verification. Those diagnosed with epilepsy or certain other antibiotics that lower seizure threshold conditions are more vulnerable to seizures if the threshold is reduced,
http://abs-international.eu/antibiotics-that-lower-seizure-threshold/
Yerba Mate and Adaptogens: Whats Inside e+ - Isagenix HealthYerba Mate and Adaptogens: Whats Inside e+ - Isagenix Health
While the naturally sourced caffeine from green tea and yerba mate are key components of e+, the real superstar is the adaptogenic blend.
http://www.isagenixhealth.net/whats-inside-e/
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Gene Expression Literature DetailGene Expression Literature Detail
J:150942 Frankel WN, Yang Y, Mahaffey CL, Beyer BJ, OBrien TP, Szt2, a novel gene for seizure threshold in mice. Genes Brain Behav. 2009 Jul;8(5):568-76 ...
http://www.informatics.jax.org/gxdlit/key/93886
Indian J Exp Biol (Monthly)Indian J Exp Biol (Monthly)
4Animal Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India and 5Department of Pharmacology, GMCH, Guwahati 781 006, India. Received 9 October 2012; revised 13 March 2013. Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect was studied using maximal electroshock-induced seizures and pentylenetetrazole-induced seizures in mice. Single oral administration of MEAB at different doses (100, 300 and 600 mg/kg, ip) significantly increased the number and duration of head poking in the HB test; rearing, assisted rearing and number of square traveled in the OF test; entries and time spent in open ...
http://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb2k13/ijeb_jun13.asp
Fluoride Action Network | The effect of sodium fluoride on responses to various central nervous system agents in ratsFluoride Action Network | The effect of sodium fluoride on responses to various central nervous system agents in rats
Rats given sodium fluoride at 10 mg/kg daily by the intraperitoneal route were more sensitive to the convulsant action of strychnine and pentylenetetrazol and to electroshock. This increase in sensitivity to CNS stimulation was observed also in two other groups of rats which were given a diet with added sodium fluoride amounting to 7 and 70 parts per million in terms of fluoride. Prolonged treatment with fluoride also lengthened the sleeping time induced by pentobarbital and increased the protective effect of diphenylhydantoin against electroshock. The increase in sensitivity to some CNS-active agents in the fluoride-treated rats disappeared after these rats were given the control diet for 2 weeks,. ...
http://fluoridealert.org/studytracker/15461/
Increased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase |i|β|/i| DeficiencyIncreased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase |i|β|/i| Deficiency
ABSTRACT. Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. Several DGK isoforms have been implicated in the pathogenesis of seizure, but the role of DGKβ in seizure is unknown. In the present study, we investigated the involvement of DGKβ in seizure using DGKβ knockout (KO) mice. Seizures were more severe in DGKβ KO mice than in wild-type (WT) mice after pentylenetetrazol (PTZ) treatment and after kainic acid treatment, but there were no differences in latency to seizure. The expression levels of DGKβ in the hippocampal CA1, CA3, or DG areas did not differ between PTZ (60 mg/kg) treatment and saline treatment. There were fewer parvalbumin-positive interneurons in the hippocampal CA3 area in DGKβ KO mice than in control WT mice, which might partly account for the increased seizure susceptibility displayed by DGKβ KO mice. These results suggest that DGKβ may play a pivotal role in the development of the relevant interneurons, and that on inherent ...
https://file.scirp.org/Html/11-2400176_33262.htm
12 oz Loose Mocha Mint Organic Yerba Mate | Phytoextractum, Plants and Extracts12 oz Loose Mocha Mint Organic Yerba Mate | Phytoextractum, Plants and Extracts
Phytoextractum 12 oz Loose Mocha Mint Organic Yerba Mate - Mocha Mint Yerba Mate Ingredients: organic Green Yerba Mate, organic Roasted Carob, organic Peppermint You can also get this product in tea bags! Mocha Mint, a rich and refreshing yerba mate blend, is excellent hot or cold. Many people love this as an after-dinner beverage, or to enhance the social mood.
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North America PTZ Camera Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast- 2022 | BusinessNorth America PTZ Camera Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast- 2022 | Business
And Others………. The report provides a basic overview of the North America PTZ Camera industry including definitions, segmentation, applications, key vendors, market drivers and market challenges. The North America PTZ Camera Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Through the statistical analysis, the report depicts the global North America PTZ Camera Industry including capacity, production, production value, cost/profit, supply/demand and import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.. Table of Contents. Chapter One North America PTZ Camera Industry Overview. • North America PTZ Camera Definition (Product Picture and Specifications). • North America PTZ Camera Classification and Application. • North America PTZ Camera Industry Chain Structure. • North America PTZ Camera ...
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Mate Factor Organic Yerba Mate Chai Loose Tea 12 oz (340 g) Pkg - Swanson Health ProductsMate Factor Organic Yerba Mate Chai Loose Tea 12 oz (340 g) Pkg - Swanson Health Products
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Yerba Mate Tea | Uses | Yerba Mate Tea Benefits | PipingRock Health ProductsYerba Mate Tea | Uses | Yerba Mate Tea Benefits | PipingRock Health Products
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Yerba Mate & Guayusa Teas & Blends, Mood: Balancing, Body: Light, Occasion: SPA, Flavor: MintyYerba Mate & Guayusa Teas & Blends, Mood: Balancing, Body: Light, Occasion: SPA, Flavor: Minty
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Yerba mate tea: Drink in moderation - latimesYerba mate tea: Drink in moderation - latimes
Teas from across the globe are becoming more and more popular in the U.S. One relative newcomer, yerba mate, is attracting fans for its allegedly jitter-free caffeine boost and high antioxidant
http://articles.latimes.com/2009/mar/16/health/he-nutrition16
Autoantibodies to the N-methyl-D-aspartate receptor and seizure susceptibility in mice - MRC Weatherall Institute of Molecular...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.imm.ox.ac.uk/publications/568159
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Yerba Prima LivCleanse Formula 650mg 60 tab -- VitaGloYerba Prima LivCleanse Formula 650mg 60 tab -- VitaGlo
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Convulsions: Causes, definition, and treatmentConvulsions: Causes, definition, and treatment
Convulsions are common in some types of seizures and rare in a few other conditions. Learn more about the causes of convulsions and what to do if someone experiences them here.
https://www.medicalnewstoday.com/articles/324330
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ConvulsantConvulsant
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs ... Some convulsants such as pentetrazol and flurothyl were previously used in shock therapy in psychiatric medicine, as an ... Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. Convulsions ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ...
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Trevor Dunns Trio-ConvulsantTrevor Dunn's Trio-Convulsant
... is an avant-garde jazz trio led by Mr. Bungle bassist Trevor Dunn with guitarist Mary Halvorson ... "Trevor Dunn's Trio-Convulsant , Album Discography". AllMusic. Retrieved 12 February 2019. Trevor Dunn at Ipecac Trevor Dunn's ...
https://en.wikipedia.org/wiki/Trevor_Dunn's_Trio-Convulsant
FlurothylFlurothyl
The convulsant properties of flurothyl pose a challenge to unifying theories of general anesthetics such as the Meyer-Overton ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... Flurothyl was at one time studied in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such ...
https://en.wikipedia.org/wiki/Flurothyl
Dejerine-Roussy syndromeDejerine-Roussy syndrome
Newer pharmaceuticals include anti-convulsants and Kampo medicine. As there is no scientific basis in the analgesic efficacy of ... Anti-convulsants reduce neuronal hyperexcitability, effectively targeting Dejerine-Roussy syndrome. Gabapentin and pregabalin ... are the most common anti-convulsants. They have significant efficacy in treatment of peripheral and central neuropathic pain. ...
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Bicyclic phosphateBicyclic phosphate
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https://en.wikipedia.org/wiki/Bicyclic_phosphate
Salla diseaseSalla disease
Anti-convulsant medication may control seizure episodes. Physical therapists can assist an affected individual to build muscle ...
https://en.wikipedia.org/wiki/Salla_disease
2022 Birthday Honours2022 Birthday Honours
Co-founder, Independent Fetal Anti-Convulsant Trust. For services to People with Disabilities. Virginia Jill Williams-Ellis. ...
https://en.wikipedia.org/wiki/2022_Birthday_Honours
Nonsynaptic plasticityNonsynaptic plasticity
These neurons become highly sensitized to convulsant agents. It has been shown that seizures early in life can predispose one ...
https://en.wikipedia.org/wiki/Nonsynaptic_plasticity
TBPSTBPS
... (tert-butylbicyclophosphorothionate) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... Convulsants, Neurotoxins, Tert-butyl compounds, Organothiophosphate esters, Oxygen heterocycles, GABAA receptor negative ... "Solubilization and anionic regulation of cerebral sedative and convulsant receptors labeled with [35S] tert- ...
https://en.wikipedia.org/wiki/TBPS
Translocator proteinTranslocator protein
Sedative yet also convulsant and anxiogenic in mice. Peptides Anthralin - 16kDa polypeptide, binds to both TSPO receptor and ...
https://en.wikipedia.org/wiki/Translocator_protein
IsoflurothylIsoflurothyl
Convulsant Flurothyl Sevoflurane Krasowski, MD (27 April 2000). "Differential modulatory actions of the volatile convulsant ... Isoflurothyl is a fluorinated ether related to the inhalational convulsant flurothyl. It is the structural isomer of flurothyl ...
https://en.wikipedia.org/wiki/Isoflurothyl
BIDNBIDN
... is a GABA receptor antagonist and convulsant. Cloflubicyne TBPS EBOB IPTBO Rauh, James J; Holyoke, Caleb W; Kleier, Daniel ... Convulsants, Norbornanes, Cyclopentanes, Nitriles, Organofluorides, Trifluoromethyl compounds, GABAA receptor negative ...
https://en.wikipedia.org/wiki/BIDN
FG-7142FG-7142
It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and ... Convulsants, GABAA receptor negative allosteric modulators, Nootropics, All stub articles, Biochemistry stubs). ...
https://en.wikipedia.org/wiki/FG-7142
FrogFrog
The chemicals involved may be irritants, hallucinogens, convulsants, nerve poisons or vasoconstrictors. Many predators of frogs ...
https://en.wikipedia.org/wiki/Frog
CloflubicyneCloflubicyne
BIDN EBOB Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: ... It's an irreversible GABA receptor antagonist with powerful convulsant effects. ... Convulsants, GABAA receptor negative allosteric modulators, Irreversible antagonists, Norbornanes, Nitriles, Trifluoromethyl ...
https://en.wikipedia.org/wiki/Cloflubicyne
CrimidineCrimidine
... is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was ... permanently deactivating the enzyme Crimidine is a fast acting convulsant, with an LD50 of 5 mg/kg. Earliest symptoms can ... Convulsants, Pesticides, Pyrimidines, Chloroarenes, Acetylcholinesterase inhibitors, Chloropyrimidines, Vitamin B6 antagonists ...
https://en.wikipedia.org/wiki/Crimidine
IPTBOIPTBO
Bowery, N.G.; Collins, J.F.; Hill, R.G.; Pearson, S. (April 1976). "GABA antagonism as a possible basis for the convulsant ... IPTBO is both a convulsant and a stimulant, essentially causing an overload of chemical signals in the brain and overexciting ... IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant ...
https://en.wikipedia.org/wiki/IPTBO
List of researchers in underwater divingList of researchers in underwater diving
Naval Medical Research Institute Report 92-73 (Report). Paton, W.D. (March 1967). "Experiments on the convulsant and ...
https://en.wikipedia.org/wiki/List_of_researchers_in_underwater_diving
PethidinePethidine
Norpethidine is toxic and has convulsant and hallucinogenic effects. The toxic effects mediated by the metabolites cannot be ... Convulsants, Ethyl esters, Euphoriants, Glycine receptor antagonists, Kappa-opioid receptor agonists, Local anesthetics, Mu- ...
https://en.wikipedia.org/wiki/Pethidine
Hewison v Meridian Shipping Services PteHewison v Meridian Shipping Services Pte
Mr Hewison had epilepsy and needed anti-convulsant drugs. He concealed his illness so that he could do offshore work with his ...
https://en.wikipedia.org/wiki/Hewison_v_Meridian_Shipping_Services_Pte
History of electroconvulsive therapy in the United KingdomHistory of electroconvulsive therapy in the United Kingdom
Mowbray RM (1959) Historical aspects of electric convulsant therapy. Scottish Medical Journal 4: 373-378. Cerletti U (1956) ...
https://en.wikipedia.org/wiki/History_of_electroconvulsive_therapy_in_the_United_Kingdom
Debutantes & CentipedesDebutantes & Centipedes
Trevor Dunn's Trio Convulsant accessed December 5, 2017 Schulte, Tom. Trevor Dunn's Trio-Convulsant: Debutantes & Centipedes - ... Trio-Convulsant blend free and mainstream jazz, sub culture grunge rock or at times heavy metal as the overabundance of ... Debutantes & Centipedes is an album by bassist Trevor Dunn's band trio-convulsant which was released in 1998 on the Dutch Buzz ...
https://en.wikipedia.org/wiki/Debutantes_&_Centipedes
Trimethylolpropane phosphiteTrimethylolpropane phosphite
... is very toxic and is a convulsant. LD50 is 1.1 mg per kg bodyweight (mice, i.p.). Ende, ...
https://en.wikipedia.org/wiki/Trimethylolpropane_phosphite
AlstonineAlstonine
Costa-Campos L, Iwu M, Elisabetsky E (August 2004). "Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine". ... Also unlike clozapine, alstonine lacks pro-convulsant activity in mice. Ajmalicine Corynanthine Deserpidine Mitragynine ...
https://en.wikipedia.org/wiki/Alstonine
StrychnineStrychnine
Longo VG, Silvestrini B, Bovet D (May 1959). "An investigation of convulsant properties of the 5-7-diphenyl-1-3-diazadamantan-6 ... Sandberg F, Kristianson K (September 1970). "A comparative study of the convulsant effects of strychnos alkaloids". Acta ... due to its convulsant effects. One notorious instance of its use was during the 1904 Olympics marathon, when track-and-field ... Convulsants, Lactams, Indole alkaloids, Avicides, Bitter compounds, Glycine receptor antagonists, Ethers, Nitrogen heterocycles ...
https://en.wikipedia.org/wiki/Strychnine
Anti-Convulsants - DESHAB PHARMACYAnti-Convulsants - DESHAB PHARMACY
Anti-Convulsants. Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of ...
https://deshabpharmacy.com/shop/product-category/anti-convulsants/
IMSEAR at SEARO: Anti-convulsant therapy in eclampsia.
Anti-convulsant therapy in eclampsia. Journal of Postgraduate Medicine. 1989 Apr; 35(2): 66-9. ...
https://imsear.searo.who.int/handle/123456789/115499
Characterization of the interaction between a novel convulsant agent, by Robert F. Halliwell, Jiping Su et al."Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al.
In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ... is a lethal convulsant in vivo and an antagonist of rodent GABA receptors in vitro. ... Characterization of the interaction between a novel convulsant agent, norbiphen, and GABAA and other ligand-gated ion channels ... In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ...
https://scholarlycommons.pacific.edu/phs-facarticles/415/
Anti Convulsants - Sodium Valproate Tablet Exporter from NagpurAnti Convulsants - Sodium Valproate Tablet Exporter from Nagpur
Exporter of Anti Convulsants - Sodium Valproate Tablet, Valneb CR 300 Tablets, Valneb CR 200 Tablets and D Valneb 250 Tablets ... Anti Convulsants We are a leading Exporter of sodium valproate tablet, valneb cr 300 tablets, valneb cr 200 tablets, d valneb ...
https://www.laharpharmaceuticals.com/anti-convulsants.html
Inquiry | Fetal Anti Convulsant Syndrome AssociationInquiry | Fetal Anti Convulsant Syndrome Association
This is a devastating blow for the Irish Valproate Campaign. It took us months of work at The.... Read More ...
https://facsassociation.org/category/inquiry/
Anti Convulsant Archives - Meds-online 24Anti Convulsant Archives - Meds-online 24
Anti Allergic Anti Anginal Antibiotic Anti Convulsant Anti Depressant Anti Diabetic Anti Fungal Anti Hypertensive Anti ...
https://meds-online24.com/product-category/anti-convulsant/
Cage convulsants inhibit picrotoxinin binding<...Cage convulsants inhibit picrotoxinin binding<...
Cage convulsants inhibit picrotoxinin binding. / Ticku, Maharaj K.; Olsen, R. W.. In: Neuropharmacology, Vol. 18, No. 3, ... Ticku, MK & Olsen, RW 1979, Cage convulsants inhibit picrotoxinin binding, Neuropharmacology, vol. 18, no. 3, pp. 315-318. ... Ticku, Maharaj K. ; Olsen, R. W. / Cage convulsants inhibit picrotoxinin binding. In: Neuropharmacology. 1979 ; Vol. 18, No. 3 ... title = "Cage convulsants inhibit picrotoxinin binding",. abstract = "Several types of cage compounds are highly toxic to ...
https://scholars.uthscsa.edu/en/publications/cage-convulsants-inhibit-picrotoxinin-binding
Angela Verbrugge: Love for Connoisseurs (Gut Strings) - JazzTimesAngela Verbrugge: Love for Connoisseurs (Gut Strings) - JazzTimes
Trevor Dunns Trio-Convulsant avec Folie à Quatre: Séances (Pyroclastic). Trevor Dunn is the consummate model of jazz-metal ... "Trevor Dunns Trio-Convulsant avec Folie à Quatre: Séances (Pyroclastic)" ...
https://jazztimes.com/reviews/albums/angela-verbrugge-love-for-connoisseurs-gut-strings/
Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in...Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in...
Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in ... Dive into the research topics of Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/ ...
https://profiles.wustl.edu/en/publications/convulsant-potencies-of-tetrazoles-are-highly-correlated-with-act/fingerprints/
A poison centers ten-year experience with flumazenil administration to acutely poisoned adultsA poison center's ten-year experience with flumazenil administration to acutely poisoned adults
Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and ... There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. ...
https://pubmed.ncbi.nlm.nih.gov/22766408/?dopt=AbstractPlus
WebWISER - CHEMM-ISTWebWISER - CHEMM-IST
The CHEMM Intelligent Syndromes Tool (CHEMM-IST) is an advanced form of FALCON: A Decision Support System for Hazardous Materials Incidents and Terrorism Response. FALCON was developed through knowledge engineering at the James Madison University as an undergraduate thesis project by student James Brandon Shreckhise (2006 undergraduate project and also described in limited detail in one publication1). The key expert involved in the development of FALCON is medical toxicologist Dr. Mark Kirk, and Dr. Kirk has been involved with other experts in medicine and emergency response in the development of CHEMM-IST. Through a series of interviews by Mr. Shreckhise with Dr. Kirk during the development of FALCON, Dr. Kirks diagnostic expertise was first modeled using decision trees. These decision trees were then engineered into IF-THEN rules and used to create a prototype expert system. CHEMM-IST started with the foundation of FALCON; however, CHEMM-ISTs design and implementation is very different, ...
https://webwiser.nlm.nih.gov/tools/Chemmist
Scorched Earth :: Ink 19Scorched Earth :: Ink 19
Trevor Dunns Trio-Convulsant avec Folie À Quatre. Music Reviews. Séances (Pyroclastic Records). Review by Bob Pomeroy. ...
https://ink19.com/2002/03/magazine/music-reviews/a95eie-scorched-earth
November, 2022 - Alabama Jazz Hall of FameNovember, 2022 - Alabama Jazz Hall of Fame
Trevor Dunns Trio-Convulsant avec Folie à Quatre: Séances (Pyroclastic). Trevor Dunn is the consummate model of jazz-metal ...
https://jazzhall.com/2022/11/
Drugs in Cerebral Palsy - 1st EditionDrugs in Cerebral Palsy - 1st Edition
Chapter 7 Anti-Convulsant Drugs. Chapter 8 Drugs, Behavior and the Family. Chapter 9 Toxic Effects of Drugs. Appendix Drugs in ... The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter ...
https://www.elsevier.com/books/drugs-in-cerebral-palsy/denhoff/978-1-4831-9681-7
CaffeineCaffeine
Convulsants. Bicuculline • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone. Phenylaminooxazoles. 4-Methyl-aminorex ...
https://www.bionity.com/en/encyclopedia/Caffeine.html
Printer-friendly Seizures/Epilepsy page | Childbrain.com
Side Effects of the Anti-Convulsant Medications. For the most part, the anti-convulsant medications are well tolerated. A ... The newer anti-convulsants are generally safer except for Felbatol and may cause some specific side effects causing discomfort ... All of them currently seizure-free, off any other anti-convulsants, and followed by me for some mild AD/HD and behavioral ... The liver may be affected by all the traditional anti-convulsant, but most seriously in children younger than 3 years of age. A ...
https://www.childbrain.com/patient-education/printer-friendly-seizures-epilepsy-page/
Pain Relief Market Size | Share | Trend | Revenue Report by 2030Pain Relief Market Size | Share | Trend | Revenue Report by 2030
Anti-convulsants. *Anti-depressants. *Other Non- Narcotic Analgesic. *Devices *Neuro-stimulation devices *Transcutaneous ...
https://www.emergenresearch.com/amp/press-release/global-pain-relief-market
Top 200 drugs 2013 Quiz - By FarmMissyTop 200 drugs 2013 Quiz - By FarmMissy
anti-convulsant C-V. promethazine. antihistamine. propranolol. hypertension. quetiapine. antipsychotic. quinapril. ACE- ...
https://www.sporcle.com/games/FarmMissy/top-200-drugs-2013
SéanceSéance
Trevor Dunn ... " data-original-title="" title="">Trevor Dunn unearths this heretical movement for his third Trio-Convulsant ...
https://wn.com/S%C3%A9ance
Jazz and Improvised | The WholeNoteJazz and Improvised | The WholeNote
Séances - Trevor Dunns Trio-Convulsant avec Folie à Quatre Details Written by Stuart Broomer Category: Jazz and Improvised ... Trevor Dunns Trio-Convulsant avec Folie à Quatre. Pyroclastic Records (store.pyroclasticrecords.com) ... He first formed Trio-Convulsant in the mid-1990s, then reformed it briefly in 2004 with then unknown, now celebrated, guitarist ...
https://www.thewholenote.com/index.php/booksrecords2/jazzaimprovised
Artisanal CBD May Provide Less Seizure Control Than Pharma CBDArtisanal CBD May Provide Less Seizure Control Than Pharma CBD
Cohen pointed out that some of the hundreds of compounds in marijuana could be "pro-convulsant." ...
http://www.medscape.com/viewarticle/926122
Using Medical Cannabis - Americans for Safe AccessUsing Medical Cannabis - Americans for Safe Access
Reduces seizure frequency/anti-convulsant. *Some noted side-effects from use of Indicas include feelings of tiredness and " ...
https://www.safeaccessnow.org/using_medical_cannabis
Erowid.org: Erowid Reference 8715 : Letter From A Master Addict To Dangerous Drugs : Burroughs WErowid.org: Erowid Reference 8715 : Letter From A Master Addict To Dangerous Drugs : Burroughs W
In overdose it is a strong convulsant poison. The antidote is a barbiturate or other strong, anti-convulsant sedative. Anyone ...
https://erowid.org/references/refs_view.php?ID=8715&S=Scopolamine
Media | Mary Halvorson
A DAY IN THE LIFE: IMPRESSIONS OF PEPPER ...
https://www.maryhalvorson.com/media
US8722085B2 - Methods for administering weight loss medications - Google Patents
230000001773 anti-convulsant Effects 0.000 description 40 * 230000001430 anti-depressive Effects 0.000 description 40 ...
https://patents.google.com/patent/US8722085/en
Order Paper titleOrder Paper title
11amFetal anti-convulsant syndrome: Anas Sarwar. (The sitting will be suspended from 11.30am to 2.30pm.) ...
https://publications.parliament.uk/pa/cm/cmagenda/OrderPaper4final.html
Journal of Postgraduate Medicine: Table of contentJournal of Postgraduate Medicine: Table of content
Anti-convulsant therapy in eclampsia.. p. 66. JR Maheshwari, SV Desai, MD Hansotia, VR Walvekar. PMID:0002621663. Seventy four ...
https://jpgmonline.com/showbackIssue.asp?issn=0022-3859
Comment History - Mad In AmericaComment History - Mad In America
Anti-convulsants work for some people with central nervous system disorders although caution is needed with them as well ( ... Not anti-convulsants: thats Code 966. Not barbiturates or sleep drugs like Ambien: thats Code 967, Sedative-Hypnotics. ...
https://www.madinamerica.com/comment-history/?user_id=836
Therapy in eclampsiaPregabalinAnxiolyticSeizuresGabapentinINSECTICIDESDrugsMedicationsLithiumCompoundsDrugAgentEffectsPropertiesTitleControlSeizuresMedicationEpilepsySeizure disordersPicrotoxinPotentSEDATIONDrugsMigraineDepakoteANTISearchMedicines
Therapy in eclampsia1
  • IMSEAR at SEARO: Anti-convulsant therapy in eclampsia. (who.int)
Pregabalin1
  • The other 10% took stronger painkillers, either morphine or pregabalin, an anti-convulsant. (news24.com)
Anxiolytic1
  • Allopregnanolone (3α5α-P), pregnanolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABA A receptors (GABA A Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects. (jbc.org)
Seizures5
  • There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. (nih.gov)
  • Development of seizures was associated with exposure to a pro-convulsant drug. (nih.gov)
  • For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
  • Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
  • Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
Gabapentin1
  • Gabapentin belongs to a class of drugs called anti-convulsants whereas Nortriptyline belongs to tricyclic antidepressants. (apollopharmacy.in)
INSECTICIDES1
  • Intrinsic lethality of chloride-channel-directed insecticides and convulsants in mammals. (semanticscholar.org)
Drugs2
  • The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. (elsevier.com)
  • Drugs that decrease cyclosporin levels: Nafcillin, rifampicin, anti-convulsants. (pediatriconcall.com)
Medications2
  • Are you taking anti-convulsants or anti-seizure medications? (mayo.edu)
  • Anti-convulsants are powerful medications that *still* haven't made the grade the way benzos do. (dr-bob.org)
Lithium1
  • Lithium plus all of the anti-convulsants used to treat bipolar disorder. (corrections.com)
Compounds2
  • These compounds have convulsant activity resembling the action of picrotoxin, a synaptic antagonist of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA). (uthscsa.edu)
  • Cohen pointed out that some of the hundreds of compounds in marijuana could be "pro-convulsant. (medscape.com)
Drug1
  • Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and after flumazenil administration. (nih.gov)
Agent1
  • Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al. (pacific.edu)
Effects2
  • Pro-convulsant and anticholinergic effects were also evaluated. (bvsalud.org)
  • Phytol is grassy in its scent and is known for its relaxing effects and is researched as an anti-convulsant. (indigrowmi.com)
Properties1
  • Convulsant Properties of Cyclotrimethylenetrinitramine (RDX): Spontaneous, Audiogenic, and Amygdaloid Kindled Seizure Activity (Journal Version). (epa.gov)
Title1
  • Los efectos del cannabidiol lo convierten en una alternativa, of the title and research adicional a la terapéutica convencional, para el control de síntomas en trastornos neurológicos, disminuyendo de forma objectives, exhaustive sostenida el número total de episodios con un perfil de seguridad aceptable. (bvsalud.org)
Control2
  • Como parte de las terapias alternativas para el control de síntomas refractarios en enfermedades avanzadas destaca el uso de cannabidiol. (bvsalud.org)
  • de determinar el uso del cannabidiol para el control de síntomas neurológicos refractarios en pacientes con síndromes convulsivos y enfermedades neurodegenerativas, se realizó una búsqueda bibliográfica en Pubmed, Scopus y Embase. (bvsalud.org)
Seizures10
  • Seizures can be managed using anti-convulsant medications. (news-medical.net)
  • For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
  • Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
  • Q:Despite the fact that doctors have got me diagnosed as epileptic, I know I am not and that the underlying cause of my seizures is anti-convulsants. (healthy.net)
  • Although doctors these days claim to be more cautious about automatically handing out anti-convulsant drugs to children with mild blackouts and seizures, the conventional wisdom among most doctors still is that, until suppressed by drug treatment, seizures will recur, and that drug treatment can affect the course of the disease, reducing the risk of early epilepsy turning into an intractible disorder. (healthy.net)
  • Phenobarbital is the number one choice of anti-convulsants for recurrent and uncontrolled feline seizures (such as in epilepsy). (vetinfo.com)
  • Phenobarbital is the oldest and most popular anti-convulsant and depressant drug that is used to fight recurrent seizures in cats. (vetinfo.com)
  • They gave us anti convulsants in case she started to have seizures in the night. (earthclinic.com)
  • Aggressive IV fluids to help with excretion, sedatives to calm the pet, specific heart medications to reduce the heart rate and blood pressure, anti-convulsants for seizures, antacids (such as Pepcid) for stomach discomfort and diarrhea. (petpoisonhelpline.com)
  • Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
Medication4
  • One dog needed anti-convulsant medication. (tuftsyourdog.com)
  • Andreina suffers from a condition called Myoclonus, a neurological condition that causes involuntary and very painful muscle jerks, which needs medical attention and easy access to anti-convulsant medication. (gofundme.com)
  • Pcr with central heating and quality being the face frequently, co-director of xanax, stop convulsions and anti-convulsant medication. (cleverlearn.com)
  • Prescription drugs prescribed with a physician in the ache center software incorporate ache medicines, nonsteroidal anti-inflammatories (NSAID), steroids to reduce swelling, muscle relaxants or anti-nervousness medication to lower pressure, and antidepressants or anti-convulsants to aid management certain varieties of neural soreness. (hiazintus.com)
Epilepsy2
  • A still further object of the present invention is to set forth new amino-benzamide anti-convulsant drugs and method for using the same for the treatment of epilepsy. (justia.com)
  • After successive investigations involving EEG and a short course of anti-convulsants, the neurologist concluded that the line between ASD and epilepsy was a blurry one and ruled that the abnormalities shown on EGG could be better accounted for by AS. (latitudes.org)
Seizure disorders2
  • This quiz includes anti-convulsant drugs for seizure disorders. (proprofs.com)
  • CBD has primarily been marketed as an anti-convulsant agent for rare seizure disorders, though some newer indications are being investigated. (observerxtra.com)
Picrotoxin1
  • as assessed by seizure activity measures: severity, frequency, latency, and duration after injection of convulsant drugs, picrotoxin, or a β-carboline benzodiazepine (BDZ) inverse agonist. (jneurosci.org)
Potent3
  • The highly potent anti-convulsant activity of 4-amino-N-(alpha-methylbenzyl)-benzamide offers some unique advantages over currently available drugs. (justia.com)
  • It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. (journalfeeds.online)
  • It is half as potent as meperidine as an analgesic but 2-3 times more potent as a convulsant. (loinc.org)
SEDATION3
  • It belongs in a category of anti-convulsants, which generally induce sedation and alleviate tension or anxiety and produce short-term insomnia. (selfgrowth.com)
  • It shares stiiizy cartridges which would cause sedation, muscle relaxation and acts as anti-convulsant. (cannabizshop.online)
  • It stocks stiiizy cartridges which might motive sedation, muscle rest and acts as anti-convulsant. (cannabizshop.online)
Drugs7
  • She was immediately placed on anti-convulsants, although the first convulsion didn't appear until after she'd been on the drugs. (healthy.net)
  • Some of the drugs implicated in triggering autoimmune responses include anti-convulsants and potentiated sulfonamides. (b-naturals.com)
  • Treatment that is progressive, starting with common analgesic drugs like ibuprofen, then moving to tricyclic anti-depressants or anti-convulsants. (stroke.org)
  • Anti-convulsant drugs reduce the sensitivity of these nerves, preventing them from spontaneously firing off. (xshotpix.com)
  • the list of dosages for the anti convulsant drugs less frequently used. (vetmedteam.com)
  • It is probable that drugs that increase serotonergic transmission are less convulsant or, even, more anticonvulsant than others. (antidepressantsfacts.com)
  • To quote the authors of that paper, "The most common offenders in cases of cognitive disorders in the elderly are psychotropic drugs, drugs with anti-cholinergic properties, sedatives, anti-hypertensives, anti-convulsants, and cardiac drugs. (secondopinionnewsletter.com)
Migraine1
  • Well I've read that this kind of disorder can be due to Topamax, an anti-convulsant drug which can be taken also for migraine headache. (horizonsweb.info)
Depakote1
  • She was also taking the anti-convulsant Depakote (valproate) and the anti-psychotic Seroquel (quetiapine fumarate) to stabilise her mood. (newscientist.com)
ANTI20
  • This invention relates to a new type of anti-convulsant drug. (justia.com)
  • There is, therefore, a need for a new type of anti-convulsant drug which will have fewer side-effects than those presently used. (justia.com)
  • It is, accordingly, one object of the present invention to set forth a new anti-convulsant drug. (justia.com)
  • Additionally, the amide offers a wide margin of safety between the dose required to produce anti-convulsant effects and the dose which produces any central nervous system side-effects. (justia.com)
  • The anti-convulsant amide (4) was administered to mice and rats as a solution. (justia.com)
  • SNRIs, anti-convulsants). (cdc.gov)
  • In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. (journalfeeds.online)
  • Hydantoins are Anti-convulsants. (proprofs.com)
  • It possesses a number of known therapeutic effects, such as anxioltytic and anti-convulsant effects. (norml.org)
  • They did all they could with the anti convulsants possible. (natural-dog-health-remedies.com)
  • Would you willingly drink water laced with antibiotics, anti-convulsants, mood stabilizers and sex hormones? (ei-resource.org)
  • The paramedics have secured intravenous access prior to arrival but have not given any anti-convulsants. (bestbets.org)
  • Lorazepam has a much longer duration of anti-convulsant action than diazepam and has an equivalent onset of action. (bestbets.org)
  • The role of newer anti-convulsants and botox injections in refractory cases are being investigated. (annalsofian.org)
  • From drinking CBD mocktails as an alternative to wine to caring for sore muscles with a CBD salve or soaking in a tub with a CBD-lace bath bomb, moms everywhere are loving its anti-inflammatory, antioxidant, anti-psychotic, anti-convulsant, and antidepressant properties. (parents.com)
  • The Clinic's website describes multiple treatments for IED such as, "anti-convulsants, anti-anxiety agents, mood regulators, antidepressants" as well as extolling on the potential benefits of counseling sessions. (feinbergwaller.com)
  • CBDV is a molecule in the cannabis plant that has shown promising results as an anti-convulsant, and for which GW Pharmaceuticals already has phase 1 clinical trial results in adults. (nsw.gov.au)
  • This discusses why therapy with dopamine, in mixture along with various other treatments, such as anti-convulsants and also anticonvulsants, is usually efficient responsible electric motor troubles, especially in the event where the disease has actually certainly not built at a later phase. (findaspring.com)
  • Based on the Treatment Type, the Peripheral Neuritis Treatment Market analysis covers Anti-convulsants, Anti-depressants, Others, Pain Relievers. (consainsights.com)
  • Use: Anti- convulsant in petit mal. (nih.gov)
Search1
  • Existe limitada información respecto al uso de search of information in cannabidiol en enfermedades neurodegenerativas, por lo que no se ha evidenciado su efectividad. (bvsalud.org)
Medicines1
  • Medicines web site http://www.who.int/medicines/areas/quality_assurance/en/index.html. (who.int)
Colin Hinton: Simulacra (Panoramic) - JazzTimes
Colin Hinton: Simulacra (Panoramic) - JazzTimes (jazztimes.com)
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Steven R. Smith :: Ink 19 (ink19.com)
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Melatonin: MedlinePlus Supplements (medlineplus.gov)
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Top 200 drugs 2013 Quiz - By FarmMissy (sporcle.com)
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Using Medical Cannabis - Americans for Safe Access (safeaccessnow.org)
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Artisanal CBD May Provide Less Seizure Control Than Pharma CBD (medscape.com)
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Comment History - Mad In America (madinamerica.com)
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Cancer Clinical Trials Contact Form - Mayo Clinic Research (mayo.edu)
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New World Notes: ON THE RUNWAY (secondlife.blogs.com)
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What Exactly is a "Mood Stabilizer?" (corrections.com)
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Poisoning by an Illegally Imported Chinese Rodenticide Containing Tetramethylenedisulfotetramine --- New York City, 2002 (cdc.gov)
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Seizures and medications: What to know (medicalnewstoday.com)
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Begriffe mit K | Medizin-Lexikon | gesundheit.de (gesundheit.de)
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Blow Up #293 (ottobre 2022) (blowupmagazine.com)
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Tert-butylbicyclo-2-benzoate | Semantic Scholar (semanticscholar.org)
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Paracetamol for dementia | Life (news24.com)
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Re: Trashing Benzos. Mr. Scott | Psycho-Babble (dr-bob.org)
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DailyMed - BENZTROPINE MESYLATE tablet (dailymed.nlm.nih.gov)
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Analgesic Effects of Treatments for Non-specific Low Back Pain (medscape.com)
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VIRACEPT® (nelfinavir mesylate) TABLETS and ORAL POWDER (dailymed.nlm.nih.gov)
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IgA and IgG Subclass Deficiencies Clinical Presentation: History, Physical, Causes (emedicine.medscape.com)
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Information for CounterACT Applicants | National Institute of Neurological Disorders and Stroke (ninds.nih.gov)
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