Convulsants
Flurothyl
Ethosuximide
Pentylenetetrazole
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
Strychnine
Picrotoxin
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Bicuculline
Seizures
Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (1/415)
The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity. (+info)Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives. (2/415)
A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate. (+info)Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. (3/415)
CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at least two GABA binding sites, a higher-affinity site (EC50-1 = 11.0 microM) and a lower-affinity site (EC50-2 = 334.2 microM), on two or more populations of cells. The effects of GABAR allosteric modulators on peak concentration-dependent GABAR currents were complex and included monophasic (loreclezole) or multiphasic (diazepam) enhancement, mixed enhancement/inhibition (DMCM, zolpidem) or multiphasic inhibition (zinc). Monophasic (70% of cells) or biphasic (30% of cells) enhancement of GABAR currents by diazepam suggested three different sites on GABARs (EC50-1 =1.8 nM; EC50-2 = 75.8 nM; EC50-3 = 275.9 nM) revealing GABAR heterogeneity. The imidazopyridine zolpidem enhanced GABAR currents in 70% of cells with an EC50 = 222.5 nM, suggesting a predominance of moderate affinity alpha2 (or alpha3-) subtype-containing BZ Type IIA receptors. A small fraction of cells (10%) had a high affinity for zolpidem, something that is suggestive of alpha1 subtype-containing BZ Type I receptors. The remaining 30% of cells were insensitive to or inhibited by zolpidem, suggesting the presence of alpha5 subtype-containing BZ Type IIB receptors. Whether BZ Type I and Type II receptors coexist could not be determined. The beta-carboline methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) inhibited GABAR currents in all cells at midnanomolar concentrations, but in addition, potentiated GABAR currents in some cells at low nanomolar concentrations, characterizing two groups of cells, the latter likely due to functional assembly of alpha5betaxgamma2GABARs. In all cells, GABAR currents were moderately sensitive (EC50 = 9 microM) to loreclezole, consistent with a relatively greater beta3 subtype, than beta1 subtype, subunit mRNA expression. Two populations of cells were identified based on their sensitivities to zinc(IC50 = 28 and 182 microM), suggesting the presence of at least two GABAR isoforms including alpha5beta3gamma2 GABARs. Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABAR isoforms. (+info)Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. (4/415)
To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1. (+info)Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. (5/415)
Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in human temporal lobe epilepsy and rodent epilepsy models. Whether this plasticity results from the remodeling of preexisting mossy fibers or instead reflects an abnormality of developing dentate granule cells is unknown. Because these neurons continue to be generated in the adult rodent and their production increases after seizures, mossy fibers that arise from either developing or mature granule cells are potential substrates for this network plasticity. Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats. A single dose of 5 Gy irradiation blocked cell proliferation and eliminated putative progenitor cells in the dentate subgranular proliferative zone. Irradiation 1 d before pilocarpine-induced status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures. Two irradiations, 1 d before and 4 d after status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent mossy fiber reorganization in the dentate molecular layer. These results indicate that dentate granule cell neurogenesis in the mature hippocampal formation is vulnerable to the effects of low-dose ionizing irradiation. Furthermore, the development of aberrant mossy fiber remodeling in the absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizure-induced network reorganization. (+info)Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. (6/415)
BACKGROUND: Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the anesthetic action of barbiturates. The authors compared the effects of depressant [R(-)] and convulsant [S(+)] stereoisomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on the AMPA and gamma-aminobutyric acid type A (GABA(A)) receptor-mediated currents to determine if the inhibitory effects on AMPA receptors correlate to the in vivo effects of the isomers. METHOD: The authors measured whole-cell currents in the rat cultured cortical neuron at holding potential of -60 mV. Kainate 500 microM was applied as the agonist for AMPA receptors. Thiopental (3-300 microM), R(-)-MPPB or S(+)-MPPB (100-1,000 microM) was coapplied with kainate under the condition in which the GABA(A) receptor-mediated current was blocked. Effects of MPPB isomers on the current elicited by GABA 1 microM were studied in the separate experiments. RESULTS: Thiopental inhibited the kainate-induced current reversibly and in a dose-dependent manner, with a concentration for 50% inhibition of 49.3 microM. Both R(-)-MPPB and S(+)-MPPB inhibited the kainate-induced current with a little stereoselectivity. R(-)-MPPB was slightly but significantly more potent than S(+)-MPPB. In contrast, R(-)-MPPB enhanced but S(+)-MPPB reduced the GABA-induced current. CONCLUSIONS: Both convulsant and depressant stereoisomers of the barbiturate inhibited the AMPA receptor-mediated current despite of their opposite effects on the central nervous system in vivo. Although thiopental exhibited a considerable inhibition of AMPA receptors, the results suggest that the inhibition of AMPA receptors contributes little to the hypnotic action of the barbiturates. (+info)Analytical detection and quantitation of strychnine in chemically fixed organ tissues. (7/415)
This study reports the results of the detection and quantitation of strychnine in formalin-fixed tissues and in the formalin solutions in which the tissues were fixed. The toxicological analyses were performed on formalin-fixed liver and kidney samples and formalin solutions (10% buffered pH 7) in which the same samples from a case of acute strychnine poisoning were preserved. The analyses carried out at the time of autopsy on body fluid and tissues (bile, 2.40 mg/L; stomach contents, 14.2 mg; liver, 6.68 mg/kg; kidney, 2.68 mg/kg) allowed the identification of this substance as cause of death. The tissue samples were preserved in formalin solutions for 8 weeks. The analyses performed on formalin-fixed tissues (liver and kidney) and on formalin solutions, in which the same tissues were preserved, permitted the detection and quantitation of strychnine (liver, 1.59 mg/kg; formalin from the liver, 1.80 mg/L; kidney, 0.98 mg/kg; formalin from the kidney, 1.11 mg/L). The results indicate that this particular toxic substance also shows good stability in biological specimens subjected to chemical fixation. (+info)GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. (8/415)
gamma-Aminobutyric acid (GABA)-activated channels in embryonic (5-8 wk old) human dorsal root ganglion (DRG) neurons in dissociated culture were characterized by whole cell and single-channel techniques. All DRG neurons when held at negative holding membrane potentials displayed inward current to micromolar concentrations of GABA applied by pressure pulses from closely positioned micropipettes. The current was directly proportional to the concentration of GABA (EC50, 111 microM; Hill coefficient, 1.7). DRG neurons also responded to micromolar concentrations of pentobarbital and alphaxalone but not to cis-4-aminocrotonic acid (CACA), glycine, or taurine. Baclofen (100 microM) affected neither the holding currents nor K+ conductance (when patch pipettes were filled with 130 mM KCl) caused by depolarizing pulses. Whole cell GABA-currents were blocked by bicuculline, picrotoxin, and t-butylbicyclophosphorothionate (TBPS; all at 100 microM). The reversal potential of whole cell GABA-currents was close to the theoretical Cl- equilibrium potential, shifting with changes in intracellular Cl- concentration in a manner expected for Cl--selective channels. The whole cell I-V curve for GABA-induced currents demonstrated slight outward rectification with nearly symmetrical outside and inside Cl- concentrations. Spectral analysis of GABA-induced membrane current fluctuations showed that the kinetic components were best fitted by a triple Lorentzian function. The apparent elementary conductance for GABA-activated Cl- channels determined from the power spectra was 22.6 pS. Single-channel recordings from cell-attached patches with pipettes containing 10 microM GABA indicated that GABA-activated channels have a main and a subconductance level with values of 30 and 19 pS, respectively. Mean open and closed times of the channel were characterized by two or three exponential decay functions, suggesting two or three open channel states and two closed states. Single channels showed a lack of rectification. The actions of GABA on cultured human embryonic DRG neurons are mediated through the activation of GABAA receptors with properties corresponding to those found in the CNS of human and other mammalian species but differing from those of cultured human adult DRG neurons. (+info)Buy online generic Neurontin (Gabapentin) / Anti Convulsants / Prescription
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Convulsant
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs ... Some convulsants such as pentetrazol and flurothyl were previously used in shock therapy in psychiatric medicine, as an ... Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. Convulsions ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ...
Trevor Dunn's Trio-Convulsant
... is an avant-garde jazz trio led by Mr. Bungle bassist Trevor Dunn with guitarist Mary Halvorson ... "Trevor Dunn's Trio-Convulsant , Album Discography". AllMusic. Retrieved 12 February 2019. Trevor Dunn at Ipecac Trevor Dunn's ...
Flurothyl
The convulsant properties of flurothyl pose a challenge to unifying theories of general anesthetics such as the Meyer-Overton ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... Flurothyl was at one time studied in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such ...
Dejerine-Roussy syndrome
Newer pharmaceuticals include anti-convulsants and Kampo medicine. As there is no scientific basis in the analgesic efficacy of ... Anti-convulsants reduce neuronal hyperexcitability, effectively targeting Dejerine-Roussy syndrome. Gabapentin and pregabalin ... are the most common anti-convulsants. They have significant efficacy in treatment of peripheral and central neuropathic pain. ...
Methyl fluoroacetate
MFA is a convulsant poison. It causes severe convulsions in poisoned victims. Death results from respiratory failure. For a ... Methyl fluoroacetate causes progressive depression of respiration and is a convulsant poison, in most animals. When applied to ... The difficulties of treatments are stressed as methyl fluoroacetate is both a powerful convulsant and a respiratory depressant ... Convulsants, Acetate esters, Methyl esters, Chemical weapons, Poisons, Fluoroacetates). ...
Mr. Bungle
Trevor Dunn joined Patton in Fantômas and Tomahawk as well as forming his own jazz band, Trevor Dunn's Trio Convulsant; he also ... "Trevor Dunn's Trio Convulsant Biography". Ipecac Recordings Official Site. Retrieved May 20, 2007. "The Tango Saloon Biography ...
Picrotoxin
... also acts as a convulsant. In larger doses, it has been found to induce clonic seizures or cardiac dysrhythmias, ... Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. It mainly ... Convulsants, Lactones, Epoxides, Chloride channel blockers, Neurotoxins, Plant toxins). ...
Pericine
It may also have convulsant effects. Pericine has been prepared in the laboratory by total synthesis. Vobasine Isovoacristine ...
Trevor Dunn
In 1998, Dunn formed his Trio-Convulsant. Their first release, Debutantes & Centipedes, features Dunn on bass, Adam Levy on ... "Ipecac Recordings - Trevor Dunn's Trio Convulsant". Ipecac.com. Retrieved July 7, 2011. "Biography". Trevordunn.net. Retrieved ... Secret Chiefs 3 and with his own avant-garde jazz/rock ensemble Trevor Dunn's Trio-Convulsant. He is also a member of the band ... 1950's Czech Contrabass used with Trevor Dunn's Trio-Convulsant, occasionally with Mr. Bungle and with King Buzzo 1991 Alembic ...
Bicyclic phosphate
They act as GABA receptor antagonists and have potent convulsant effects. Convulsant TBPS TBPO IPTBO Bellet, E. M.; Casida, J. ... BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA ... v t e (Bicyclic phosphates, Convulsants, Neurotoxins, GABAA receptor negative allosteric modulators, Organophosphates, ...
Salla disease
Anti-convulsant medication may control seizure episodes. Physical therapists can assist an affected individual to build muscle ...
2022 Birthday Honours
Co-founder, Independent Fetal Anti-Convulsant Trust. For services to People with Disabilities. Virginia Jill Williams-Ellis. ...
Nonsynaptic plasticity
These neurons become highly sensitized to convulsant agents. It has been shown that seizures early in life can predispose one ...
TBPS
... (tert-butylbicyclophosphorothionate) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... Convulsants, Neurotoxins, Tert-butyl compounds, Organothiophosphate esters, Oxygen heterocycles, GABAA receptor negative ... "Solubilization and anionic regulation of cerebral sedative and convulsant receptors labeled with [35S] tert- ...
Translocator protein
Sedative yet also convulsant and anxiogenic in mice. Peptides Anthralin - 16kDa polypeptide, binds to both TSPO receptor and ...
Isoflurothyl
Convulsant Flurothyl Sevoflurane Krasowski, MD (27 April 2000). "Differential modulatory actions of the volatile convulsant ... Isoflurothyl is a fluorinated ether related to the inhalational convulsant flurothyl. It is the structural isomer of flurothyl ...
BIDN
... is a GABA receptor antagonist and convulsant. Cloflubicyne TBPS EBOB IPTBO Rauh, James J; Holyoke, Caleb W; Kleier, Daniel ... Convulsants, Norbornanes, Cyclopentanes, Nitriles, Organofluorides, Trifluoromethyl compounds, GABAA receptor negative ...
FG-7142
It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and ... Convulsants, GABAA receptor negative allosteric modulators, Nootropics, All stub articles, Biochemistry stubs). ...
Frog
The chemicals involved may be irritants, hallucinogens, convulsants, nerve poisons or vasoconstrictors. Many predators of frogs ...
Cloflubicyne
BIDN EBOB Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: ... It's an irreversible GABA receptor antagonist with powerful convulsant effects. ... Convulsants, GABAA receptor negative allosteric modulators, Irreversible antagonists, Norbornanes, Nitriles, Trifluoromethyl ...
Crimidine
... is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was ... permanently deactivating the enzyme Crimidine is a fast acting convulsant, with an LD50 of 5 mg/kg. Earliest symptoms can ... Convulsants, Pesticides, Pyrimidines, Chloroarenes, Acetylcholinesterase inhibitors, Chloropyrimidines, Vitamin B6 antagonists ...
IPTBO
Bowery, N.G.; Collins, J.F.; Hill, R.G.; Pearson, S. (April 1976). "GABA antagonism as a possible basis for the convulsant ... IPTBO is both a convulsant and a stimulant, essentially causing an overload of chemical signals in the brain and overexciting ... IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant ...
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Naval Medical Research Institute Report 92-73 (Report). Paton, W.D. (March 1967). "Experiments on the convulsant and ...
Pethidine
Norpethidine is toxic and has convulsant and hallucinogenic effects. The toxic effects mediated by the metabolites cannot be ... Convulsants, Ethyl esters, Euphoriants, Glycine receptor antagonists, Kappa-opioid receptor agonists, Local anesthetics, Mu- ...
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Mr Hewison had epilepsy and needed anti-convulsant drugs. He concealed his illness so that he could do offshore work with his ...
History of electroconvulsive therapy in the United Kingdom
Mowbray RM (1959) Historical aspects of electric convulsant therapy. Scottish Medical Journal 4: 373-378. Cerletti U (1956) ...
Debutantes & Centipedes
Trevor Dunn's Trio Convulsant accessed December 5, 2017 Schulte, Tom. Trevor Dunn's Trio-Convulsant: Debutantes & Centipedes - ... Trio-Convulsant blend free and mainstream jazz, sub culture grunge rock or at times heavy metal as the overabundance of ... Debutantes & Centipedes is an album by bassist Trevor Dunn's band trio-convulsant which was released in 1998 on the Dutch Buzz ...
Trimethylolpropane phosphite
... is very toxic and is a convulsant. LD50 is 1.1 mg per kg bodyweight (mice, i.p.). Ende, ...
Alstonine
Costa-Campos L, Iwu M, Elisabetsky E (August 2004). "Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine". ... Also unlike clozapine, alstonine lacks pro-convulsant activity in mice. Ajmalicine Corynanthine Deserpidine Mitragynine ...
Strychnine
Longo VG, Silvestrini B, Bovet D (May 1959). "An investigation of convulsant properties of the 5-7-diphenyl-1-3-diazadamantan-6 ... Sandberg F, Kristianson K (September 1970). "A comparative study of the convulsant effects of strychnos alkaloids". Acta ... due to its convulsant effects. One notorious instance of its use was during the 1904 Olympics marathon, when track-and-field ... Convulsants, Lactams, Indole alkaloids, Avicides, Bitter compounds, Glycine receptor antagonists, Ethers, Nitrogen heterocycles ...
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"Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al.
In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ... is a lethal convulsant in vivo and an antagonist of rodent GABA receptors in vitro. ... Characterization of the interaction between a novel convulsant agent, norbiphen, and GABAA and other ligand-gated ion channels ... In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ...
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Cage convulsants inhibit picrotoxinin binding<...
Cage convulsants inhibit picrotoxinin binding. / Ticku, Maharaj K.; Olsen, R. W.. In: Neuropharmacology, Vol. 18, No. 3, ... Ticku, MK & Olsen, RW 1979, Cage convulsants inhibit picrotoxinin binding, Neuropharmacology, vol. 18, no. 3, pp. 315-318. ... Ticku, Maharaj K. ; Olsen, R. W. / Cage convulsants inhibit picrotoxinin binding. In: Neuropharmacology. 1979 ; Vol. 18, No. 3 ... title = "Cage convulsants inhibit picrotoxinin binding",. abstract = "Several types of cage compounds are highly toxic to ...
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Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in...
A poison center's ten-year experience with flumazenil administration to acutely poisoned adults
Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and ... There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. ...
WebWISER - CHEMM-IST
The CHEMM Intelligent Syndromes Tool (CHEMM-IST) is an advanced form of FALCON: A Decision Support System for Hazardous Materials Incidents and Terrorism Response. FALCON was developed through knowledge engineering at the James Madison University as an undergraduate thesis project by student James Brandon Shreckhise (2006 undergraduate project and also described in limited detail in one publication1). The key expert involved in the development of FALCON is medical toxicologist Dr. Mark Kirk, and Dr. Kirk has been involved with other experts in medicine and emergency response in the development of CHEMM-IST. Through a series of interviews by Mr. Shreckhise with Dr. Kirk during the development of FALCON, Dr. Kirks diagnostic expertise was first modeled using decision trees. These decision trees were then engineered into IF-THEN rules and used to create a prototype expert system. CHEMM-IST started with the foundation of FALCON; however, CHEMM-ISTs design and implementation is very different, ...
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Side Effects of the Anti-Convulsant Medications. For the most part, the anti-convulsant medications are well tolerated. A ... The newer anti-convulsants are generally safer except for Felbatol and may cause some specific side effects causing discomfort ... All of them currently seizure-free, off any other anti-convulsants, and followed by me for some mild AD/HD and behavioral ... The liver may be affected by all the traditional anti-convulsant, but most seriously in children younger than 3 years of age. A ...
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Journal of Postgraduate Medicine: Table of content
Therapy in eclampsia1
- IMSEAR at SEARO: Anti-convulsant therapy in eclampsia. (who.int)
Pregabalin1
- The other 10% took stronger painkillers, either morphine or pregabalin, an anti-convulsant. (news24.com)
Anxiolytic1
- Allopregnanolone (3α5α-P), pregnanolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABA A receptors (GABA A Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects. (jbc.org)
Seizures5
- There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. (nih.gov)
- Development of seizures was associated with exposure to a pro-convulsant drug. (nih.gov)
- For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
- Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
- Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
Gabapentin1
- Gabapentin belongs to a class of drugs called anti-convulsants whereas Nortriptyline belongs to tricyclic antidepressants. (apollopharmacy.in)
INSECTICIDES1
- Intrinsic lethality of chloride-channel-directed insecticides and convulsants in mammals. (semanticscholar.org)
Drugs2
- The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. (elsevier.com)
- Drugs that decrease cyclosporin levels: Nafcillin, rifampicin, anti-convulsants. (pediatriconcall.com)
Medications2
- Are you taking anti-convulsants or anti-seizure medications? (mayo.edu)
- Anti-convulsants are powerful medications that *still* haven't made the grade the way benzos do. (dr-bob.org)
Lithium1
- Lithium plus all of the anti-convulsants used to treat bipolar disorder. (corrections.com)
Compounds2
- These compounds have convulsant activity resembling the action of picrotoxin, a synaptic antagonist of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA). (uthscsa.edu)
- Cohen pointed out that some of the hundreds of compounds in marijuana could be "pro-convulsant. (medscape.com)
Drug1
- Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and after flumazenil administration. (nih.gov)
Agent1
- Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al. (pacific.edu)
Effects2
- Pro-convulsant and anticholinergic effects were also evaluated. (bvsalud.org)
- Phytol is grassy in its scent and is known for its relaxing effects and is researched as an anti-convulsant. (indigrowmi.com)
Properties1
- Convulsant Properties of Cyclotrimethylenetrinitramine (RDX): Spontaneous, Audiogenic, and Amygdaloid Kindled Seizure Activity (Journal Version). (epa.gov)
Title1
- Los efectos del cannabidiol lo convierten en una alternativa, of the title and research adicional a la terapéutica convencional, para el control de síntomas en trastornos neurológicos, disminuyendo de forma objectives, exhaustive sostenida el número total de episodios con un perfil de seguridad aceptable. (bvsalud.org)
Control2
- Como parte de las terapias alternativas para el control de síntomas refractarios en enfermedades avanzadas destaca el uso de cannabidiol. (bvsalud.org)
- de determinar el uso del cannabidiol para el control de síntomas neurológicos refractarios en pacientes con síndromes convulsivos y enfermedades neurodegenerativas, se realizó una búsqueda bibliográfica en Pubmed, Scopus y Embase. (bvsalud.org)
Seizures10
- Seizures can be managed using anti-convulsant medications. (news-medical.net)
- For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
- Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
- Q:Despite the fact that doctors have got me diagnosed as epileptic, I know I am not and that the underlying cause of my seizures is anti-convulsants. (healthy.net)
- Although doctors these days claim to be more cautious about automatically handing out anti-convulsant drugs to children with mild blackouts and seizures, the conventional wisdom among most doctors still is that, until suppressed by drug treatment, seizures will recur, and that drug treatment can affect the course of the disease, reducing the risk of early epilepsy turning into an intractible disorder. (healthy.net)
- Phenobarbital is the number one choice of anti-convulsants for recurrent and uncontrolled feline seizures (such as in epilepsy). (vetinfo.com)
- Phenobarbital is the oldest and most popular anti-convulsant and depressant drug that is used to fight recurrent seizures in cats. (vetinfo.com)
- They gave us anti convulsants in case she started to have seizures in the night. (earthclinic.com)
- Aggressive IV fluids to help with excretion, sedatives to calm the pet, specific heart medications to reduce the heart rate and blood pressure, anti-convulsants for seizures, antacids (such as Pepcid) for stomach discomfort and diarrhea. (petpoisonhelpline.com)
- Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
Medication4
- One dog needed anti-convulsant medication. (tuftsyourdog.com)
- Andreina suffers from a condition called Myoclonus, a neurological condition that causes involuntary and very painful muscle jerks, which needs medical attention and easy access to anti-convulsant medication. (gofundme.com)
- Pcr with central heating and quality being the face frequently, co-director of xanax, stop convulsions and anti-convulsant medication. (cleverlearn.com)
- Prescription drugs prescribed with a physician in the ache center software incorporate ache medicines, nonsteroidal anti-inflammatories (NSAID), steroids to reduce swelling, muscle relaxants or anti-nervousness medication to lower pressure, and antidepressants or anti-convulsants to aid management certain varieties of neural soreness. (hiazintus.com)
Epilepsy2
- A still further object of the present invention is to set forth new amino-benzamide anti-convulsant drugs and method for using the same for the treatment of epilepsy. (justia.com)
- After successive investigations involving EEG and a short course of anti-convulsants, the neurologist concluded that the line between ASD and epilepsy was a blurry one and ruled that the abnormalities shown on EGG could be better accounted for by AS. (latitudes.org)
Seizure disorders2
- This quiz includes anti-convulsant drugs for seizure disorders. (proprofs.com)
- CBD has primarily been marketed as an anti-convulsant agent for rare seizure disorders, though some newer indications are being investigated. (observerxtra.com)
Picrotoxin1
- as assessed by seizure activity measures: severity, frequency, latency, and duration after injection of convulsant drugs, picrotoxin, or a β-carboline benzodiazepine (BDZ) inverse agonist. (jneurosci.org)
Potent3
- The highly potent anti-convulsant activity of 4-amino-N-(alpha-methylbenzyl)-benzamide offers some unique advantages over currently available drugs. (justia.com)
- It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. (journalfeeds.online)
- It is half as potent as meperidine as an analgesic but 2-3 times more potent as a convulsant. (loinc.org)
SEDATION3
- It belongs in a category of anti-convulsants, which generally induce sedation and alleviate tension or anxiety and produce short-term insomnia. (selfgrowth.com)
- It shares stiiizy cartridges which would cause sedation, muscle relaxation and acts as anti-convulsant. (cannabizshop.online)
- It stocks stiiizy cartridges which might motive sedation, muscle rest and acts as anti-convulsant. (cannabizshop.online)
Drugs7
- She was immediately placed on anti-convulsants, although the first convulsion didn't appear until after she'd been on the drugs. (healthy.net)
- Some of the drugs implicated in triggering autoimmune responses include anti-convulsants and potentiated sulfonamides. (b-naturals.com)
- Treatment that is progressive, starting with common analgesic drugs like ibuprofen, then moving to tricyclic anti-depressants or anti-convulsants. (stroke.org)
- Anti-convulsant drugs reduce the sensitivity of these nerves, preventing them from spontaneously firing off. (xshotpix.com)
- the list of dosages for the anti convulsant drugs less frequently used. (vetmedteam.com)
- It is probable that drugs that increase serotonergic transmission are less convulsant or, even, more anticonvulsant than others. (antidepressantsfacts.com)
- To quote the authors of that paper, "The most common offenders in cases of cognitive disorders in the elderly are psychotropic drugs, drugs with anti-cholinergic properties, sedatives, anti-hypertensives, anti-convulsants, and cardiac drugs. (secondopinionnewsletter.com)
Migraine1
- Well I've read that this kind of disorder can be due to Topamax, an anti-convulsant drug which can be taken also for migraine headache. (horizonsweb.info)
Depakote1
- She was also taking the anti-convulsant Depakote (valproate) and the anti-psychotic Seroquel (quetiapine fumarate) to stabilise her mood. (newscientist.com)
ANTI20
- This invention relates to a new type of anti-convulsant drug. (justia.com)
- There is, therefore, a need for a new type of anti-convulsant drug which will have fewer side-effects than those presently used. (justia.com)
- It is, accordingly, one object of the present invention to set forth a new anti-convulsant drug. (justia.com)
- Additionally, the amide offers a wide margin of safety between the dose required to produce anti-convulsant effects and the dose which produces any central nervous system side-effects. (justia.com)
- The anti-convulsant amide (4) was administered to mice and rats as a solution. (justia.com)
- SNRIs, anti-convulsants). (cdc.gov)
- In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. (journalfeeds.online)
- Hydantoins are Anti-convulsants. (proprofs.com)
- It possesses a number of known therapeutic effects, such as anxioltytic and anti-convulsant effects. (norml.org)
- They did all they could with the anti convulsants possible. (natural-dog-health-remedies.com)
- Would you willingly drink water laced with antibiotics, anti-convulsants, mood stabilizers and sex hormones? (ei-resource.org)
- The paramedics have secured intravenous access prior to arrival but have not given any anti-convulsants. (bestbets.org)
- Lorazepam has a much longer duration of anti-convulsant action than diazepam and has an equivalent onset of action. (bestbets.org)
- The role of newer anti-convulsants and botox injections in refractory cases are being investigated. (annalsofian.org)
- From drinking CBD mocktails as an alternative to wine to caring for sore muscles with a CBD salve or soaking in a tub with a CBD-lace bath bomb, moms everywhere are loving its anti-inflammatory, antioxidant, anti-psychotic, anti-convulsant, and antidepressant properties. (parents.com)
- The Clinic's website describes multiple treatments for IED such as, "anti-convulsants, anti-anxiety agents, mood regulators, antidepressants" as well as extolling on the potential benefits of counseling sessions. (feinbergwaller.com)
- CBDV is a molecule in the cannabis plant that has shown promising results as an anti-convulsant, and for which GW Pharmaceuticals already has phase 1 clinical trial results in adults. (nsw.gov.au)
- This discusses why therapy with dopamine, in mixture along with various other treatments, such as anti-convulsants and also anticonvulsants, is usually efficient responsible electric motor troubles, especially in the event where the disease has actually certainly not built at a later phase. (findaspring.com)
- Based on the Treatment Type, the Peripheral Neuritis Treatment Market analysis covers Anti-convulsants, Anti-depressants, Others, Pain Relievers. (consainsights.com)
- Use: Anti- convulsant in petit mal. (nih.gov)
Search1
- Existe limitada información respecto al uso de search of information in cannabidiol en enfermedades neurodegenerativas, por lo que no se ha evidenciado su efectividad. (bvsalud.org)
Medicines1
- Medicines web site http://www.who.int/medicines/areas/quality_assurance/en/index.html. (who.int)