A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (1/415)The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity. (+info)
Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives. (2/415)A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate. (+info)
Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. (3/415)CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at least two GABA binding sites, a higher-affinity site (EC50-1 = 11.0 microM) and a lower-affinity site (EC50-2 = 334.2 microM), on two or more populations of cells. The effects of GABAR allosteric modulators on peak concentration-dependent GABAR currents were complex and included monophasic (loreclezole) or multiphasic (diazepam) enhancement, mixed enhancement/inhibition (DMCM, zolpidem) or multiphasic inhibition (zinc). Monophasic (70% of cells) or biphasic (30% of cells) enhancement of GABAR currents by diazepam suggested three different sites on GABARs (EC50-1 =1.8 nM; EC50-2 = 75.8 nM; EC50-3 = 275.9 nM) revealing GABAR heterogeneity. The imidazopyridine zolpidem enhanced GABAR currents in 70% of cells with an EC50 = 222.5 nM, suggesting a predominance of moderate affinity alpha2 (or alpha3-) subtype-containing BZ Type IIA receptors. A small fraction of cells (10%) had a high affinity for zolpidem, something that is suggestive of alpha1 subtype-containing BZ Type I receptors. The remaining 30% of cells were insensitive to or inhibited by zolpidem, suggesting the presence of alpha5 subtype-containing BZ Type IIB receptors. Whether BZ Type I and Type II receptors coexist could not be determined. The beta-carboline methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) inhibited GABAR currents in all cells at midnanomolar concentrations, but in addition, potentiated GABAR currents in some cells at low nanomolar concentrations, characterizing two groups of cells, the latter likely due to functional assembly of alpha5betaxgamma2GABARs. In all cells, GABAR currents were moderately sensitive (EC50 = 9 microM) to loreclezole, consistent with a relatively greater beta3 subtype, than beta1 subtype, subunit mRNA expression. Two populations of cells were identified based on their sensitivities to zinc(IC50 = 28 and 182 microM), suggesting the presence of at least two GABAR isoforms including alpha5beta3gamma2 GABARs. Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABAR isoforms. (+info)
Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. (4/415)To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1. (+info)
Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. (5/415)Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in human temporal lobe epilepsy and rodent epilepsy models. Whether this plasticity results from the remodeling of preexisting mossy fibers or instead reflects an abnormality of developing dentate granule cells is unknown. Because these neurons continue to be generated in the adult rodent and their production increases after seizures, mossy fibers that arise from either developing or mature granule cells are potential substrates for this network plasticity. Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats. A single dose of 5 Gy irradiation blocked cell proliferation and eliminated putative progenitor cells in the dentate subgranular proliferative zone. Irradiation 1 d before pilocarpine-induced status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures. Two irradiations, 1 d before and 4 d after status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent mossy fiber reorganization in the dentate molecular layer. These results indicate that dentate granule cell neurogenesis in the mature hippocampal formation is vulnerable to the effects of low-dose ionizing irradiation. Furthermore, the development of aberrant mossy fiber remodeling in the absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizure-induced network reorganization. (+info)
Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. (6/415)BACKGROUND: Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the anesthetic action of barbiturates. The authors compared the effects of depressant [R(-)] and convulsant [S(+)] stereoisomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on the AMPA and gamma-aminobutyric acid type A (GABA(A)) receptor-mediated currents to determine if the inhibitory effects on AMPA receptors correlate to the in vivo effects of the isomers. METHOD: The authors measured whole-cell currents in the rat cultured cortical neuron at holding potential of -60 mV. Kainate 500 microM was applied as the agonist for AMPA receptors. Thiopental (3-300 microM), R(-)-MPPB or S(+)-MPPB (100-1,000 microM) was coapplied with kainate under the condition in which the GABA(A) receptor-mediated current was blocked. Effects of MPPB isomers on the current elicited by GABA 1 microM were studied in the separate experiments. RESULTS: Thiopental inhibited the kainate-induced current reversibly and in a dose-dependent manner, with a concentration for 50% inhibition of 49.3 microM. Both R(-)-MPPB and S(+)-MPPB inhibited the kainate-induced current with a little stereoselectivity. R(-)-MPPB was slightly but significantly more potent than S(+)-MPPB. In contrast, R(-)-MPPB enhanced but S(+)-MPPB reduced the GABA-induced current. CONCLUSIONS: Both convulsant and depressant stereoisomers of the barbiturate inhibited the AMPA receptor-mediated current despite of their opposite effects on the central nervous system in vivo. Although thiopental exhibited a considerable inhibition of AMPA receptors, the results suggest that the inhibition of AMPA receptors contributes little to the hypnotic action of the barbiturates. (+info)
Analytical detection and quantitation of strychnine in chemically fixed organ tissues. (7/415)This study reports the results of the detection and quantitation of strychnine in formalin-fixed tissues and in the formalin solutions in which the tissues were fixed. The toxicological analyses were performed on formalin-fixed liver and kidney samples and formalin solutions (10% buffered pH 7) in which the same samples from a case of acute strychnine poisoning were preserved. The analyses carried out at the time of autopsy on body fluid and tissues (bile, 2.40 mg/L; stomach contents, 14.2 mg; liver, 6.68 mg/kg; kidney, 2.68 mg/kg) allowed the identification of this substance as cause of death. The tissue samples were preserved in formalin solutions for 8 weeks. The analyses performed on formalin-fixed tissues (liver and kidney) and on formalin solutions, in which the same tissues were preserved, permitted the detection and quantitation of strychnine (liver, 1.59 mg/kg; formalin from the liver, 1.80 mg/L; kidney, 0.98 mg/kg; formalin from the kidney, 1.11 mg/L). The results indicate that this particular toxic substance also shows good stability in biological specimens subjected to chemical fixation. (+info)
GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. (8/415)gamma-Aminobutyric acid (GABA)-activated channels in embryonic (5-8 wk old) human dorsal root ganglion (DRG) neurons in dissociated culture were characterized by whole cell and single-channel techniques. All DRG neurons when held at negative holding membrane potentials displayed inward current to micromolar concentrations of GABA applied by pressure pulses from closely positioned micropipettes. The current was directly proportional to the concentration of GABA (EC50, 111 microM; Hill coefficient, 1.7). DRG neurons also responded to micromolar concentrations of pentobarbital and alphaxalone but not to cis-4-aminocrotonic acid (CACA), glycine, or taurine. Baclofen (100 microM) affected neither the holding currents nor K+ conductance (when patch pipettes were filled with 130 mM KCl) caused by depolarizing pulses. Whole cell GABA-currents were blocked by bicuculline, picrotoxin, and t-butylbicyclophosphorothionate (TBPS; all at 100 microM). The reversal potential of whole cell GABA-currents was close to the theoretical Cl- equilibrium potential, shifting with changes in intracellular Cl- concentration in a manner expected for Cl--selective channels. The whole cell I-V curve for GABA-induced currents demonstrated slight outward rectification with nearly symmetrical outside and inside Cl- concentrations. Spectral analysis of GABA-induced membrane current fluctuations showed that the kinetic components were best fitted by a triple Lorentzian function. The apparent elementary conductance for GABA-activated Cl- channels determined from the power spectra was 22.6 pS. Single-channel recordings from cell-attached patches with pipettes containing 10 microM GABA indicated that GABA-activated channels have a main and a subconductance level with values of 30 and 19 pS, respectively. Mean open and closed times of the channel were characterized by two or three exponential decay functions, suggesting two or three open channel states and two closed states. Single channels showed a lack of rectification. The actions of GABA on cultured human embryonic DRG neurons are mediated through the activation of GABAA receptors with properties corresponding to those found in the CNS of human and other mammalian species but differing from those of cultured human adult DRG neurons. (+info)
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Welcome to MPPB | Department of Molecular Pharmacology, Physiology, and Biotechnology
MPPB faculty offer extensive experience in biotechnology and in the biomedical device industry, with research interests spanning from molecules to cells, tissues to organs to whole organisms.. Grounded in a base of chemistry, physics, math, and biology, MPPB is a basic-science department within Brown Alpert Medical School, and a full participant in the undergraduate-based Program in Biology within the Division of Biology and Medicine.. Within the Medical School, the departments educational mission is to provide medical students and MD/PhD candidates with a solid foundation in basic science and to help prepare them for a lifetime of learning and problem solving.. MPPB supports graduate and postdoctoral education by providing a highly interdisciplinary framework for individual and thematic training programs both classical and newly emerging. Brown also provides state-of-the-art equipment and resources through its Shared Resource Facilities.. Areas of study include molecular and structural ...
Proper Timing of Vaccinations to Help Develop the Best Immunity | Beef Magazine
Vaccination is one of the most important methods of protecting against infections and disease in a herd. Vaccinations reduce the occurrence of disease outbreaks and the severity of disease in a herd. Vaccination programs can be tailored to meet individual producers needs, depending on herd location, overall herd health, history of the herd and a variety of other factors. While the type of vaccine administered is a central part of herd health, the proper timing of vaccinations is also significant.. Cows and heifers should be vaccinated according to label directions prior to breeding in order to develop the best immunity and protection against several reproductive diseases. Vaccinating cows and heifers at this time allows them time to develop an immune response prior to bull exposure.. Modified-live virus (MLV) vaccines containing IBR and BVD, administered pre-breeding, seem to be the most popular choice of veterinarians and cattle producers. Killed vaccines are generally considered safer than ...
AID 772070 - Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in albino mouse assessed as...
BioAssay record AID 772070 submitted by ChEMBL: Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizures in albino mouse assessed as duration of seizure time at 100 mg/kg, ip after 0.5 hr.
Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. - Semantic Scholar
Cyclooxygenases (COXs) are rate-limiting enzymes in the metabolic pathways in which arachidonic acid is converted to prostaglandins. COX-2 is the isoform induced at injury/inflammation sites and expressed constitutively in a few tissues, such as the central nervous system, and plays a role in neurodegenerative diseases associated with increased excitatory activity. However, the role of COX-2 and its main product, prostaglandin E(2) (PGE(2)), in the convulsive states is not fully established. In this study we showed that the selective COX-2 inhibitor, celecoxib (at the dose of 2mg/kg, but not at the doses of 0.2 or 20mg/kg, p.o.), protects against the seizures induced by pentylenetetrazol (PTZ, 60 mg/kg, i.p.). The role of PGE(2) in the convulsions induced by PTZ was further investigated by administering anti-PGE(2) antibodies (4 microg/2 microl, i.c.v.), and assessing electroencephalographic changes induced by PTZ (PTZ, 60 mg/kg, i.p.). Anti-PGE(2) antibodies attenuated PTZ-induced seizures in rats. In
Pentylenetetrazole is an analeptic drug formerly used in combination with nicotinic acid (vitamin B3) in the treatment of memory defects, mental confusion, mental deterioration, and related symptoms of senility. Sold under the brand name of Menic, it allegedly provided cortical stimulation and cerebral vasodilation. Since it is a convulsant agent, it was not be administered to patients with known low convulsive threshold. ...
Publications - Core B | School of Veterinary Medicine
Publications - Core B Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice Pressly B. Vasylieva N. Barnych B, Singh V. Bruun DA, Hwang SH. Chen YJ, Johnnides S, Lein PJ. Yang J, Hammock BD, Wulff H Archives in Toxicology 2020 June:9494(6):1995-2007. PMID: 32239239
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Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the...
Dive into the research topics of Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. Together they form a unique fingerprint. ...
The central nervous system effects of a convulsant barbiturate, sodium 5-ethyl-5-(1,3-dimethylbutyl) barbiturate, were compared with the actions of pentobarbital in cats. Depending upon the dose, the convulsant barbiturate has both stimulant and depressant properties.. Under special conditions the convulsant barbiturate was shown to increase the mean convulsant dose of a timed intravenous infusion of pentylenetetrazole. Comparable amounts of pentobarbital were much more effective in increasing the mean convulsant dose of pentylenetetrazole. The depressant actions of the convulsant barbiturate appear to be real and not secondary to the stimulant effects.. The low to medium-voltage, medium to fast-frequency pattern observed in the EEG with the convulsant barbiturate was still present in three of five mesencephalic preparations verified by autopsy to be complete transections. In the remaining two preparations the convulsant barbiturate reduced the frequency of spindle bursts and prolonged the ...
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Inhibitory neurotransmission in the CNS is predominantly mediated by γ-aminobutyric acid (GABA) and glycine. Whereas GABAergic synapses are abundant in the cortex and cerebellum, glycine predominates...
Gene expression profiles of mouse brains | Genome Biology | Full Text
Inbred mouse strains have been shown to vary considerably in neurobehavioral testing. In the September 26 Proceedings of the National Academy of Science, Sandberg et al. describe the first use of DNA microarrays to determine the genetics events that might explain these phenotypic differences (Proc Natl Acad Sci USA 2000, 97:11038-11043). They compared two common inbred mouse strains (C57BL/6 and 129SvEv) by examining the expression profiles of over 10,000 genes in six different brain regions. They identified 24 genes that were differentially expressed in all brain regions of C57BL/6 animals compared with 129Sv/Ev. Furthermore, 1% of genes were differentially expressed in at least one brain region between the two strains. When comparing pentylenetetrazol-induced seizures, the immediate-early responses were similar but the overall transcriptional response was blunted in the 129SvEv strain. Sandberg et al. also found several genes that were enriched in one brain region, with the greatest ...
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Behavioral and metabolic features of repetitive seizures in immature and mature rats<...
TY - JOUR. T1 - Behavioral and metabolic features of repetitive seizures in immature and mature rats. AU - Szot, Patricia. AU - White, Sylvia S.. AU - McCarthy, Elizabeth B.. AU - Turella, Andrew. AU - Rejniak, Starr X.. AU - Schwartzkroin, Philip A. PY - 2001. Y1 - 2001. N2 - Seizure incidence varies significantly with age, with seizure susceptibility particularly high during the first few years of life. Of significant concern is what effects do brief, repetitive seizures have on the developing brain. We approached this issue by examining the change in seizure threshold, and related markers of neuronal activity and metabolic activity (c-fos mRNA and 2-deoxyglucose [2DG]), as a function of repetitive seizure episodes in immature and mature rats. Starting on postnatal day 15 (P15) (immature) or P60 (adult) rats were given two flurothyl seizures a day for 5 days (nine or ten seizures). The seizure latency profile, our measure of threshold, in immature versus adult rats across the 5-day testing ...
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PDF] Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors...
Background Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8). Opipramole (10, 20, and 50 mg/kg), ketamine (50 mg/kg), caffeine (200 mg/kg), opipramole (20 mg/kg) plus ketamine (50 mg/kg), opipramole (20 mg/kg) plus caffeine (200 mg/kg), diazepam (5 mg/kg as a positive control), and the vehicle were administered interaperitoneally 30 minutes before the injection of PTZ. The latency was recorded for the clonic, tonic-clonic seizures, and death of animals after the injection of PTZ. Kruskal-Wallis test followed by Dunns test was used for the analysis of data. Statistical
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish | Disease Models & Mechanisms
Our results show that combining the hindbrain-activating properties of VNS with the reactive triggering of RNS results in a demand-triggered stimulation paradigm that might ultimately prove to have greater utility than either modality alone. Specifically, we showed that it was possible to use the changing statistical properties of the zebrafish cerebral field potential to trigger hindbrain stimulation in reaction to proconvulsant exposure in order to attenuate PTZ-induced seizures. These results implicate a potential role for reactive vagus nerve stimulation in the treatment of epilepsy. Given the large numbers of patients with implanted vagus nerve stimulators who continue to have seizures, further investigation into the possibility of a hybrid VNS-RNS stimulation platform is warranted.. Our results also suggest that the zebrafish cerebral field potential is of sufficient complexity to make it amenable to analysis by algorithms commonly used in the quest for seizure anticipation in human. ...
JCI - Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in...
Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized that leptin receptor activation in other neuronal subtypes would have anticonvulsant activity and that intranasal leptin delivery would be an effective route of administration. We tested leptins anticonvulsant action in 2 rodent seizure models by directly injecting it into the cortex or by administering it intranasally. Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels. These seizures were briefer and less frequent upon coinjection of 4-aminopyridine and leptin. In mice, intranasal administration of leptin produced elevated brain and serum leptin levels and delayed the onset of chemical convulsant pentylenetetrazole-induced generalized convulsive seizures. Leptin also reduced neuronal spiking in an in vitro seizure model. Leptin inhibited ...
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When the gut tastes phenylalanine (PHE), leucine (LEU), glutamate (GLUT) and tryptophane (TRP), satiety ensues (Daly. 2012) -- In their most recent paper Christin Daly et al. report on the cholecystokinin (CCK) release in the gut. According to the scientists from the University of Liverpool (UK) and the Kyushu University (Japan), the effect is mediated by interactions with the gastrointestinal bitter taste receptors. Since CCK inhibits food intake and reduces appetite, this provides another mechanistic explanation for the satiety promoting effects of high protein intakes. The effects was observed only for the L- and not the D-amino acids ...
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Thujone ( ( listen)) is a ketone and a monoterpene that occurs naturally in two diastereomeric forms: (−)-α-thujone and (+)-β-thujone. It has a menthol odor. Though it is best known as a chemical compound in the spirit absinthe, which contains only small quantities of thujone, it is unlikely to be responsible for absinthes alleged psychedelic effects ...
View all posts in yerba mate
Health Benefits of Yerba Mate Yerba mate originated in South America and it is commonly known for its potency and ability to promote vitality, clarity, and well-being to those who drink it. It helps improve overall health and wellness and has numerous health benefits including a reduced risk of cardiovascular diseases and cancer. It naturally helps aid in weight loss and has antioxidant, antimicrobial, and anti-inflammatory properties. Nutritional Benefits Yerba mate tea is packed with essential nutrients that aid in maintaining good health. It is an excellent source of polyphenols, xanthines, caffeoyl derivatives and saponins. As well as a good source of vitamins […]. ...
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While the naturally sourced caffeine from green tea and yerba mate are key components of e+, the real superstar is the adaptogenic blend.
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Gene Expression Literature Detail
J:150942 Frankel WN, Yang Y, Mahaffey CL, Beyer BJ, OBrien TP, Szt2, a novel gene for seizure threshold in mice. Genes Brain Behav. 2009 Jul;8(5):568-76 ...
Indian J Exp Biol (Monthly)
4Animal Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India and 5Department of Pharmacology, GMCH, Guwahati 781 006, India. Received 9 October 2012; revised 13 March 2013. Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect was studied using maximal electroshock-induced seizures and pentylenetetrazole-induced seizures in mice. Single oral administration of MEAB at different doses (100, 300 and 600 mg/kg, ip) significantly increased the number and duration of head poking in the HB test; rearing, assisted rearing and number of square traveled in the OF test; entries and time spent in open ...
Fluoride Action Network | The effect of sodium fluoride on responses to various central nervous system agents in rats
Rats given sodium fluoride at 10 mg/kg daily by the intraperitoneal route were more sensitive to the convulsant action of strychnine and pentylenetetrazol and to electroshock. This increase in sensitivity to CNS stimulation was observed also in two other groups of rats which were given a diet with added sodium fluoride amounting to 7 and 70 parts per million in terms of fluoride. Prolonged treatment with fluoride also lengthened the sleeping time induced by pentobarbital and increased the protective effect of diphenylhydantoin against electroshock. The increase in sensitivity to some CNS-active agents in the fluoride-treated rats disappeared after these rats were given the control diet for 2 weeks,. ...
Increased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase |i|β|/i| Deficiency
ABSTRACT. Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. Several DGK isoforms have been implicated in the pathogenesis of seizure, but the role of DGKβ in seizure is unknown. In the present study, we investigated the involvement of DGKβ in seizure using DGKβ knockout (KO) mice. Seizures were more severe in DGKβ KO mice than in wild-type (WT) mice after pentylenetetrazol (PTZ) treatment and after kainic acid treatment, but there were no differences in latency to seizure. The expression levels of DGKβ in the hippocampal CA1, CA3, or DG areas did not differ between PTZ (60 mg/kg) treatment and saline treatment. There were fewer parvalbumin-positive interneurons in the hippocampal CA3 area in DGKβ KO mice than in control WT mice, which might partly account for the increased seizure susceptibility displayed by DGKβ KO mice. These results suggest that DGKβ may play a pivotal role in the development of the relevant interneurons, and that on inherent ...
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Convulsions: Causes, definition, and treatment
Convulsions are common in some types of seizures and rare in a few other conditions. Learn more about the causes of convulsions and what to do if someone experiences them here.
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A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs ... Some convulsants such as pentetrazol and flurothyl were previously used in shock therapy in psychiatric medicine, as an ... Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. Convulsions ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ...
Trevor Dunn's Trio-Convulsant
... is an avant-garde jazz trio led by Mr. Bungle bassist Trevor Dunn with guitarist Mary Halvorson ... "Trevor Dunn's Trio-Convulsant , Album Discography". AllMusic. Retrieved 12 February 2019. Trevor Dunn at Ipecac Trevor Dunn's ...
The convulsant properties of flurothyl pose a challenge to unifying theories of general anesthetics such as the Meyer-Overton ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... Flurothyl was at one time studied in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such ...
Newer pharmaceuticals include anti-convulsants and Kampo medicine. As there is no scientific basis in the analgesic efficacy of ... Anti-convulsants reduce neuronal hyperexcitability, effectively targeting Dejerine-Roussy syndrome. Gabapentin and pregabalin ... are the most common anti-convulsants. They have significant efficacy in treatment of peripheral and central neuropathic pain. ...
MFA is a convulsant poison. It causes severe convulsions in poisoned victims. Death results from respiratory failure. For a ... Methyl fluoroacetate causes progressive depression of respiration and is a convulsant poison, in most animals. When applied to ... The difficulties of treatments are stressed as methyl fluoroacetate is both a powerful convulsant and a respiratory depressant ... Convulsants, Acetate esters, Methyl esters, Chemical weapons, Poisons, Fluoroacetates). ...
Trevor Dunn joined Patton in Fantômas and Tomahawk as well as forming his own jazz band, Trevor Dunn's Trio Convulsant; he also ... "Trevor Dunn's Trio Convulsant Biography". Ipecac Recordings Official Site. Retrieved May 20, 2007. "The Tango Saloon Biography ...
... also acts as a convulsant. In larger doses, it has been found to induce clonic seizures or cardiac dysrhythmias, ... Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. It mainly ... Convulsants, Lactones, Epoxides, Chloride channel blockers, Neurotoxins, Plant toxins). ...
It may also have convulsant effects. Pericine has been prepared in the laboratory by total synthesis. Vobasine Isovoacristine ...
In 1998, Dunn formed his Trio-Convulsant. Their first release, Debutantes & Centipedes, features Dunn on bass, Adam Levy on ... "Ipecac Recordings - Trevor Dunn's Trio Convulsant". Ipecac.com. Retrieved July 7, 2011. "Biography". Trevordunn.net. Retrieved ... Secret Chiefs 3 and with his own avant-garde jazz/rock ensemble Trevor Dunn's Trio-Convulsant. He is also a member of the band ... 1950's Czech Contrabass used with Trevor Dunn's Trio-Convulsant, occasionally with Mr. Bungle and with King Buzzo 1991 Alembic ...
They act as GABA receptor antagonists and have potent convulsant effects. Convulsant TBPS TBPO IPTBO Bellet, E. M.; Casida, J. ... BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA ... v t e (Bicyclic phosphates, Convulsants, Neurotoxins, GABAA receptor negative allosteric modulators, Organophosphates, ...
Anti-convulsant medication may control seizure episodes. Physical therapists can assist an affected individual to build muscle ...
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Co-founder, Independent Fetal Anti-Convulsant Trust. For services to People with Disabilities. Virginia Jill Williams-Ellis. ...
These neurons become highly sensitized to convulsant agents. It has been shown that seizures early in life can predispose one ...
... (tert-butylbicyclophosphorothionate) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... Convulsants, Neurotoxins, Tert-butyl compounds, Organothiophosphate esters, Oxygen heterocycles, GABAA receptor negative ... "Solubilization and anionic regulation of cerebral sedative and convulsant receptors labeled with [35S] tert- ...
Sedative yet also convulsant and anxiogenic in mice. Peptides Anthralin - 16kDa polypeptide, binds to both TSPO receptor and ...
Convulsant Flurothyl Sevoflurane Krasowski, MD (27 April 2000). "Differential modulatory actions of the volatile convulsant ... Isoflurothyl is a fluorinated ether related to the inhalational convulsant flurothyl. It is the structural isomer of flurothyl ...
... is a GABA receptor antagonist and convulsant. Cloflubicyne TBPS EBOB IPTBO Rauh, James J; Holyoke, Caleb W; Kleier, Daniel ... Convulsants, Norbornanes, Cyclopentanes, Nitriles, Organofluorides, Trifluoromethyl compounds, GABAA receptor negative ...
It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and ... Convulsants, GABAA receptor negative allosteric modulators, Nootropics, All stub articles, Biochemistry stubs). ...
The chemicals involved may be irritants, hallucinogens, convulsants, nerve poisons or vasoconstrictors. Many predators of frogs ...
BIDN EBOB Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: ... It's an irreversible GABA receptor antagonist with powerful convulsant effects. ... Convulsants, GABAA receptor negative allosteric modulators, Irreversible antagonists, Norbornanes, Nitriles, Trifluoromethyl ...
... is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was ... permanently deactivating the enzyme Crimidine is a fast acting convulsant, with an LD50 of 5 mg/kg. Earliest symptoms can ... Convulsants, Pesticides, Pyrimidines, Chloroarenes, Acetylcholinesterase inhibitors, Chloropyrimidines, Vitamin B6 antagonists ...
Bowery, N.G.; Collins, J.F.; Hill, R.G.; Pearson, S. (April 1976). "GABA antagonism as a possible basis for the convulsant ... IPTBO is both a convulsant and a stimulant, essentially causing an overload of chemical signals in the brain and overexciting ... IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant ...
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Naval Medical Research Institute Report 92-73 (Report). Paton, W.D. (March 1967). "Experiments on the convulsant and ...
Norpethidine is toxic and has convulsant and hallucinogenic effects. The toxic effects mediated by the metabolites cannot be ... Convulsants, Ethyl esters, Euphoriants, Glycine receptor antagonists, Kappa-opioid receptor agonists, Local anesthetics, Mu- ...
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Mr Hewison had epilepsy and needed anti-convulsant drugs. He concealed his illness so that he could do offshore work with his ...
History of electroconvulsive therapy in the United Kingdom
Mowbray RM (1959) Historical aspects of electric convulsant therapy. Scottish Medical Journal 4: 373-378. Cerletti U (1956) ...
Debutantes & Centipedes
Trevor Dunn's Trio Convulsant accessed December 5, 2017 Schulte, Tom. Trevor Dunn's Trio-Convulsant: Debutantes & Centipedes - ... Trio-Convulsant blend free and mainstream jazz, sub culture grunge rock or at times heavy metal as the overabundance of ... Debutantes & Centipedes is an album by bassist Trevor Dunn's band trio-convulsant which was released in 1998 on the Dutch Buzz ...
... is very toxic and is a convulsant. LD50 is 1.1 mg per kg bodyweight (mice, i.p.). Ende, ...
Costa-Campos L, Iwu M, Elisabetsky E (August 2004). "Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine". ... Also unlike clozapine, alstonine lacks pro-convulsant activity in mice. Ajmalicine Corynanthine Deserpidine Mitragynine ...
Longo VG, Silvestrini B, Bovet D (May 1959). "An investigation of convulsant properties of the 5-7-diphenyl-1-3-diazadamantan-6 ... Sandberg F, Kristianson K (September 1970). "A comparative study of the convulsant effects of strychnos alkaloids". Acta ... due to its convulsant effects. One notorious instance of its use was during the 1904 Olympics marathon, when track-and-field ... Convulsants, Lactams, Indole alkaloids, Avicides, Bitter compounds, Glycine receptor antagonists, Ethers, Nitrogen heterocycles ...
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IMSEAR at SEARO: Anti-convulsant therapy in eclampsia.
"Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al.
In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ... is a lethal convulsant in vivo and an antagonist of rodent GABA receptors in vitro. ... Characterization of the interaction between a novel convulsant agent, norbiphen, and GABAA and other ligand-gated ion channels ... In the present study, the selectivity, molecular site(s) and mechanism of action of this novel convulsant were investigated ...
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Cage convulsants inhibit picrotoxinin binding<...
Cage convulsants inhibit picrotoxinin binding. / Ticku, Maharaj K.; Olsen, R. W.. In: Neuropharmacology, Vol. 18, No. 3, ... Ticku, MK & Olsen, RW 1979, Cage convulsants inhibit picrotoxinin binding, Neuropharmacology, vol. 18, no. 3, pp. 315-318. ... Ticku, Maharaj K. ; Olsen, R. W. / Cage convulsants inhibit picrotoxinin binding. In: Neuropharmacology. 1979 ; Vol. 18, No. 3 ... title = "Cage convulsants inhibit picrotoxinin binding",. abstract = "Several types of cage compounds are highly toxic to ...
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Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in...
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Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental ... Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and ... There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. ...
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Side Effects of the Anti-Convulsant Medications. For the most part, the anti-convulsant medications are well tolerated. A ... The newer anti-convulsants are generally safer except for Felbatol and may cause some specific side effects causing discomfort ... All of them currently seizure-free, off any other anti-convulsants, and followed by me for some mild AD/HD and behavioral ... The liver may be affected by all the traditional anti-convulsant, but most seriously in children younger than 3 years of age. A ...
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Séances - Trevor Dunns Trio-Convulsant avec Folie à Quatre Details Written by Stuart Broomer Category: Jazz and Improvised ... Trevor Dunns Trio-Convulsant avec Folie à Quatre. Pyroclastic Records (store.pyroclasticrecords.com) ... He first formed Trio-Convulsant in the mid-1990s, then reformed it briefly in 2004 with then unknown, now celebrated, guitarist ...
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Therapy in eclampsia1
- IMSEAR at SEARO: Anti-convulsant therapy in eclampsia. (who.int)
- The other 10% took stronger painkillers, either morphine or pregabalin, an anti-convulsant. (news24.com)
- Allopregnanolone (3α5α-P), pregnanolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABA A receptors (GABA A Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects. (jbc.org)
- There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. (nih.gov)
- Development of seizures was associated with exposure to a pro-convulsant drug. (nih.gov)
- For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
- Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
- Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
- Gabapentin belongs to a class of drugs called anti-convulsants whereas Nortriptyline belongs to tricyclic antidepressants. (apollopharmacy.in)
- Intrinsic lethality of chloride-channel-directed insecticides and convulsants in mammals. (semanticscholar.org)
- The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. (elsevier.com)
- Drugs that decrease cyclosporin levels: Nafcillin, rifampicin, anti-convulsants. (pediatriconcall.com)
- Are you taking anti-convulsants or anti-seizure medications? (mayo.edu)
- Anti-convulsants are powerful medications that *still* haven't made the grade the way benzos do. (dr-bob.org)
- Lithium plus all of the anti-convulsants used to treat bipolar disorder. (corrections.com)
- These compounds have convulsant activity resembling the action of picrotoxin, a synaptic antagonist of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA). (uthscsa.edu)
- Cohen pointed out that some of the hundreds of compounds in marijuana could be "pro-convulsant. (medscape.com)
- Variables collected included: presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and after flumazenil administration. (nih.gov)
- Characterization of the interaction between a novel convulsant agent, " by Robert F. Halliwell, Jiping Su et al. (pacific.edu)
- Pro-convulsant and anticholinergic effects were also evaluated. (bvsalud.org)
- Phytol is grassy in its scent and is known for its relaxing effects and is researched as an anti-convulsant. (indigrowmi.com)
- Convulsant Properties of Cyclotrimethylenetrinitramine (RDX): Spontaneous, Audiogenic, and Amygdaloid Kindled Seizure Activity (Journal Version). (epa.gov)
- Los efectos del cannabidiol lo convierten en una alternativa, of the title and research adicional a la terapéutica convencional, para el control de síntomas en trastornos neurológicos, disminuyendo de forma objectives, exhaustive sostenida el número total de episodios con un perfil de seguridad aceptable. (bvsalud.org)
- Como parte de las terapias alternativas para el control de síntomas refractarios en enfermedades avanzadas destaca el uso de cannabidiol. (bvsalud.org)
- de determinar el uso del cannabidiol para el control de síntomas neurológicos refractarios en pacientes con síndromes convulsivos y enfermedades neurodegenerativas, se realizó una búsqueda bibliográfica en Pubmed, Scopus y Embase. (bvsalud.org)
- Seizures can be managed using anti-convulsant medications. (news-medical.net)
- For most people with epilepsy, anti-seizure medications, also known as anti-convulsants, can successfully control seizures. (medicalnewstoday.com)
- Your veterinarian may also prescribe Gabapentin as the sole treatment for seizures, or they may instruct you to administer it with other anti-convulsants. (vetdepot.com)
- Q:Despite the fact that doctors have got me diagnosed as epileptic, I know I am not and that the underlying cause of my seizures is anti-convulsants. (healthy.net)
- Although doctors these days claim to be more cautious about automatically handing out anti-convulsant drugs to children with mild blackouts and seizures, the conventional wisdom among most doctors still is that, until suppressed by drug treatment, seizures will recur, and that drug treatment can affect the course of the disease, reducing the risk of early epilepsy turning into an intractible disorder. (healthy.net)
- Phenobarbital is the number one choice of anti-convulsants for recurrent and uncontrolled feline seizures (such as in epilepsy). (vetinfo.com)
- Phenobarbital is the oldest and most popular anti-convulsant and depressant drug that is used to fight recurrent seizures in cats. (vetinfo.com)
- They gave us anti convulsants in case she started to have seizures in the night. (earthclinic.com)
- Aggressive IV fluids to help with excretion, sedatives to calm the pet, specific heart medications to reduce the heart rate and blood pressure, anti-convulsants for seizures, antacids (such as Pepcid) for stomach discomfort and diarrhea. (petpoisonhelpline.com)
- Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
- One dog needed anti-convulsant medication. (tuftsyourdog.com)
- Andreina suffers from a condition called Myoclonus, a neurological condition that causes involuntary and very painful muscle jerks, which needs medical attention and easy access to anti-convulsant medication. (gofundme.com)
- Pcr with central heating and quality being the face frequently, co-director of xanax, stop convulsions and anti-convulsant medication. (cleverlearn.com)
- Prescription drugs prescribed with a physician in the ache center software incorporate ache medicines, nonsteroidal anti-inflammatories (NSAID), steroids to reduce swelling, muscle relaxants or anti-nervousness medication to lower pressure, and antidepressants or anti-convulsants to aid management certain varieties of neural soreness. (hiazintus.com)
- A still further object of the present invention is to set forth new amino-benzamide anti-convulsant drugs and method for using the same for the treatment of epilepsy. (justia.com)
- After successive investigations involving EEG and a short course of anti-convulsants, the neurologist concluded that the line between ASD and epilepsy was a blurry one and ruled that the abnormalities shown on EGG could be better accounted for by AS. (latitudes.org)
- This quiz includes anti-convulsant drugs for seizure disorders. (proprofs.com)
- CBD has primarily been marketed as an anti-convulsant agent for rare seizure disorders, though some newer indications are being investigated. (observerxtra.com)
- as assessed by seizure activity measures: severity, frequency, latency, and duration after injection of convulsant drugs, picrotoxin, or a β-carboline benzodiazepine (BDZ) inverse agonist. (jneurosci.org)
- The highly potent anti-convulsant activity of 4-amino-N-(alpha-methylbenzyl)-benzamide offers some unique advantages over currently available drugs. (justia.com)
- It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. (journalfeeds.online)
- It is half as potent as meperidine as an analgesic but 2-3 times more potent as a convulsant. (loinc.org)
- It belongs in a category of anti-convulsants, which generally induce sedation and alleviate tension or anxiety and produce short-term insomnia. (selfgrowth.com)
- It shares stiiizy cartridges which would cause sedation, muscle relaxation and acts as anti-convulsant. (cannabizshop.online)
- It stocks stiiizy cartridges which might motive sedation, muscle rest and acts as anti-convulsant. (cannabizshop.online)
- She was immediately placed on anti-convulsants, although the first convulsion didn't appear until after she'd been on the drugs. (healthy.net)
- Some of the drugs implicated in triggering autoimmune responses include anti-convulsants and potentiated sulfonamides. (b-naturals.com)
- Treatment that is progressive, starting with common analgesic drugs like ibuprofen, then moving to tricyclic anti-depressants or anti-convulsants. (stroke.org)
- Anti-convulsant drugs reduce the sensitivity of these nerves, preventing them from spontaneously firing off. (xshotpix.com)
- the list of dosages for the anti convulsant drugs less frequently used. (vetmedteam.com)
- It is probable that drugs that increase serotonergic transmission are less convulsant or, even, more anticonvulsant than others. (antidepressantsfacts.com)
- To quote the authors of that paper, "The most common offenders in cases of cognitive disorders in the elderly are psychotropic drugs, drugs with anti-cholinergic properties, sedatives, anti-hypertensives, anti-convulsants, and cardiac drugs. (secondopinionnewsletter.com)
- Well I've read that this kind of disorder can be due to Topamax, an anti-convulsant drug which can be taken also for migraine headache. (horizonsweb.info)
- She was also taking the anti-convulsant Depakote (valproate) and the anti-psychotic Seroquel (quetiapine fumarate) to stabilise her mood. (newscientist.com)
- This invention relates to a new type of anti-convulsant drug. (justia.com)
- There is, therefore, a need for a new type of anti-convulsant drug which will have fewer side-effects than those presently used. (justia.com)
- It is, accordingly, one object of the present invention to set forth a new anti-convulsant drug. (justia.com)
- Additionally, the amide offers a wide margin of safety between the dose required to produce anti-convulsant effects and the dose which produces any central nervous system side-effects. (justia.com)
- The anti-convulsant amide (4) was administered to mice and rats as a solution. (justia.com)
- SNRIs, anti-convulsants). (cdc.gov)
- In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. (journalfeeds.online)
- Hydantoins are Anti-convulsants. (proprofs.com)
- It possesses a number of known therapeutic effects, such as anxioltytic and anti-convulsant effects. (norml.org)
- They did all they could with the anti convulsants possible. (natural-dog-health-remedies.com)
- Would you willingly drink water laced with antibiotics, anti-convulsants, mood stabilizers and sex hormones? (ei-resource.org)
- The paramedics have secured intravenous access prior to arrival but have not given any anti-convulsants. (bestbets.org)
- Lorazepam has a much longer duration of anti-convulsant action than diazepam and has an equivalent onset of action. (bestbets.org)
- The role of newer anti-convulsants and botox injections in refractory cases are being investigated. (annalsofian.org)
- From drinking CBD mocktails as an alternative to wine to caring for sore muscles with a CBD salve or soaking in a tub with a CBD-lace bath bomb, moms everywhere are loving its anti-inflammatory, antioxidant, anti-psychotic, anti-convulsant, and antidepressant properties. (parents.com)
- The Clinic's website describes multiple treatments for IED such as, "anti-convulsants, anti-anxiety agents, mood regulators, antidepressants" as well as extolling on the potential benefits of counseling sessions. (feinbergwaller.com)
- CBDV is a molecule in the cannabis plant that has shown promising results as an anti-convulsant, and for which GW Pharmaceuticals already has phase 1 clinical trial results in adults. (nsw.gov.au)
- This discusses why therapy with dopamine, in mixture along with various other treatments, such as anti-convulsants and also anticonvulsants, is usually efficient responsible electric motor troubles, especially in the event where the disease has actually certainly not built at a later phase. (findaspring.com)
- Based on the Treatment Type, the Peripheral Neuritis Treatment Market analysis covers Anti-convulsants, Anti-depressants, Others, Pain Relievers. (consainsights.com)
- Use: Anti- convulsant in petit mal. (nih.gov)
- Existe limitada información respecto al uso de search of information in cannabidiol en enfermedades neurodegenerativas, por lo que no se ha evidenciado su efectividad. (bvsalud.org)
- Medicines web site http://www.who.int/medicines/areas/quality_assurance/en/index.html. (who.int)