Convulsants
Flurothyl
Ethosuximide
Pentylenetetrazole
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
Strychnine
Picrotoxin
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Bicuculline
Seizures
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Kv1.3 Potassium Channel
Kv1.2 Potassium Channel
Kv1.1 Potassium Channel
Receptors, Glycine
Glycine
Myoclonus
Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).
Receptors, Neurotransmitter
Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.
Glycine Agents
Amines
Drugs, Generic
Prescriptions
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Quaternary Ammonium Compounds
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Sodium
Ammonia
Ammonium Chloride
Barbiturates
Pentobarbital
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Neurotransmitter Uptake Inhibitors
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Central Nervous System
Elements, Radioactive
Metabolic Detoxication, Phase II
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
Microsomes, Liver
Glucuronides
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Glucuronosyltransferase
Bemegride
Dictionaries as Topic
Diazepam
Bipolar Disorder
Lithium
Seasonal Affective Disorder
A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.
Patient Admission
Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (1/415)
The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity. (+info)Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives. (2/415)
A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate. (+info)Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. (3/415)
CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at least two GABA binding sites, a higher-affinity site (EC50-1 = 11.0 microM) and a lower-affinity site (EC50-2 = 334.2 microM), on two or more populations of cells. The effects of GABAR allosteric modulators on peak concentration-dependent GABAR currents were complex and included monophasic (loreclezole) or multiphasic (diazepam) enhancement, mixed enhancement/inhibition (DMCM, zolpidem) or multiphasic inhibition (zinc). Monophasic (70% of cells) or biphasic (30% of cells) enhancement of GABAR currents by diazepam suggested three different sites on GABARs (EC50-1 =1.8 nM; EC50-2 = 75.8 nM; EC50-3 = 275.9 nM) revealing GABAR heterogeneity. The imidazopyridine zolpidem enhanced GABAR currents in 70% of cells with an EC50 = 222.5 nM, suggesting a predominance of moderate affinity alpha2 (or alpha3-) subtype-containing BZ Type IIA receptors. A small fraction of cells (10%) had a high affinity for zolpidem, something that is suggestive of alpha1 subtype-containing BZ Type I receptors. The remaining 30% of cells were insensitive to or inhibited by zolpidem, suggesting the presence of alpha5 subtype-containing BZ Type IIB receptors. Whether BZ Type I and Type II receptors coexist could not be determined. The beta-carboline methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) inhibited GABAR currents in all cells at midnanomolar concentrations, but in addition, potentiated GABAR currents in some cells at low nanomolar concentrations, characterizing two groups of cells, the latter likely due to functional assembly of alpha5betaxgamma2GABARs. In all cells, GABAR currents were moderately sensitive (EC50 = 9 microM) to loreclezole, consistent with a relatively greater beta3 subtype, than beta1 subtype, subunit mRNA expression. Two populations of cells were identified based on their sensitivities to zinc(IC50 = 28 and 182 microM), suggesting the presence of at least two GABAR isoforms including alpha5beta3gamma2 GABARs. Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABAR isoforms. (+info)Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. (4/415)
To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1. (+info)Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. (5/415)
Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in human temporal lobe epilepsy and rodent epilepsy models. Whether this plasticity results from the remodeling of preexisting mossy fibers or instead reflects an abnormality of developing dentate granule cells is unknown. Because these neurons continue to be generated in the adult rodent and their production increases after seizures, mossy fibers that arise from either developing or mature granule cells are potential substrates for this network plasticity. Therefore, to determine whether seizure-induced, mossy fiber synaptic reorganization arises from either developing or mature granule cell populations, we used low-dose, whole-brain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats. A single dose of 5 Gy irradiation blocked cell proliferation and eliminated putative progenitor cells in the dentate subgranular proliferative zone. Irradiation 1 d before pilocarpine-induced status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures. Two irradiations, 1 d before and 4 d after status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent mossy fiber reorganization in the dentate molecular layer. These results indicate that dentate granule cell neurogenesis in the mature hippocampal formation is vulnerable to the effects of low-dose ionizing irradiation. Furthermore, the development of aberrant mossy fiber remodeling in the absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizure-induced network reorganization. (+info)Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors. (6/415)
BACKGROUND: Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the anesthetic action of barbiturates. The authors compared the effects of depressant [R(-)] and convulsant [S(+)] stereoisomers of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) on the AMPA and gamma-aminobutyric acid type A (GABA(A)) receptor-mediated currents to determine if the inhibitory effects on AMPA receptors correlate to the in vivo effects of the isomers. METHOD: The authors measured whole-cell currents in the rat cultured cortical neuron at holding potential of -60 mV. Kainate 500 microM was applied as the agonist for AMPA receptors. Thiopental (3-300 microM), R(-)-MPPB or S(+)-MPPB (100-1,000 microM) was coapplied with kainate under the condition in which the GABA(A) receptor-mediated current was blocked. Effects of MPPB isomers on the current elicited by GABA 1 microM were studied in the separate experiments. RESULTS: Thiopental inhibited the kainate-induced current reversibly and in a dose-dependent manner, with a concentration for 50% inhibition of 49.3 microM. Both R(-)-MPPB and S(+)-MPPB inhibited the kainate-induced current with a little stereoselectivity. R(-)-MPPB was slightly but significantly more potent than S(+)-MPPB. In contrast, R(-)-MPPB enhanced but S(+)-MPPB reduced the GABA-induced current. CONCLUSIONS: Both convulsant and depressant stereoisomers of the barbiturate inhibited the AMPA receptor-mediated current despite of their opposite effects on the central nervous system in vivo. Although thiopental exhibited a considerable inhibition of AMPA receptors, the results suggest that the inhibition of AMPA receptors contributes little to the hypnotic action of the barbiturates. (+info)Analytical detection and quantitation of strychnine in chemically fixed organ tissues. (7/415)
This study reports the results of the detection and quantitation of strychnine in formalin-fixed tissues and in the formalin solutions in which the tissues were fixed. The toxicological analyses were performed on formalin-fixed liver and kidney samples and formalin solutions (10% buffered pH 7) in which the same samples from a case of acute strychnine poisoning were preserved. The analyses carried out at the time of autopsy on body fluid and tissues (bile, 2.40 mg/L; stomach contents, 14.2 mg; liver, 6.68 mg/kg; kidney, 2.68 mg/kg) allowed the identification of this substance as cause of death. The tissue samples were preserved in formalin solutions for 8 weeks. The analyses performed on formalin-fixed tissues (liver and kidney) and on formalin solutions, in which the same tissues were preserved, permitted the detection and quantitation of strychnine (liver, 1.59 mg/kg; formalin from the liver, 1.80 mg/L; kidney, 0.98 mg/kg; formalin from the kidney, 1.11 mg/L). The results indicate that this particular toxic substance also shows good stability in biological specimens subjected to chemical fixation. (+info)GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. (8/415)
gamma-Aminobutyric acid (GABA)-activated channels in embryonic (5-8 wk old) human dorsal root ganglion (DRG) neurons in dissociated culture were characterized by whole cell and single-channel techniques. All DRG neurons when held at negative holding membrane potentials displayed inward current to micromolar concentrations of GABA applied by pressure pulses from closely positioned micropipettes. The current was directly proportional to the concentration of GABA (EC50, 111 microM; Hill coefficient, 1.7). DRG neurons also responded to micromolar concentrations of pentobarbital and alphaxalone but not to cis-4-aminocrotonic acid (CACA), glycine, or taurine. Baclofen (100 microM) affected neither the holding currents nor K+ conductance (when patch pipettes were filled with 130 mM KCl) caused by depolarizing pulses. Whole cell GABA-currents were blocked by bicuculline, picrotoxin, and t-butylbicyclophosphorothionate (TBPS; all at 100 microM). The reversal potential of whole cell GABA-currents was close to the theoretical Cl- equilibrium potential, shifting with changes in intracellular Cl- concentration in a manner expected for Cl--selective channels. The whole cell I-V curve for GABA-induced currents demonstrated slight outward rectification with nearly symmetrical outside and inside Cl- concentrations. Spectral analysis of GABA-induced membrane current fluctuations showed that the kinetic components were best fitted by a triple Lorentzian function. The apparent elementary conductance for GABA-activated Cl- channels determined from the power spectra was 22.6 pS. Single-channel recordings from cell-attached patches with pipettes containing 10 microM GABA indicated that GABA-activated channels have a main and a subconductance level with values of 30 and 19 pS, respectively. Mean open and closed times of the channel were characterized by two or three exponential decay functions, suggesting two or three open channel states and two closed states. Single channels showed a lack of rectification. The actions of GABA on cultured human embryonic DRG neurons are mediated through the activation of GABAA receptors with properties corresponding to those found in the CNS of human and other mammalian species but differing from those of cultured human adult DRG neurons. (+info)
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Toxopyrimidine
... is a vitamin B6 antagonist with potent convulsant effects.[2][3] ...
Acmella oleracea
Convulsant. S. acmella. Whole plant. Hexane. Electroencephalograph response of rats Active chemicals[edit]. *. ...
Category:Neurotoxins
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Flurothyl
The convulsant properties of flurothyl pose a challenge to unifying theories of general anesthetics such as the Meyer-Overton ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA. 196 (1): 29-30. April 1966. doi:10.1001/jama.196.1.29. ... Flurothyl was at one time studied in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such ...
Neuropathic pain
Anti-Convulsant/ Anti-Depressant. Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous ...
Opioid receptor
convulsant effects. *physical dependence. *may modulate μ-opioid receptor-mediated respiratory depression ...
Dejerine-Roussy syndrome
Newer pharmaceuticals include anti-convulsants and Kampo medicine. As there is no scientific basis in the analgesic efficacy of ... Anti-convulsants reduce neuronal hyperexcitability, effectively targeting Dejerine-Roussy syndrome. Gabapentin and pregabalin ... are the most common anti-convulsants. They have significant efficacy in treatment of peripheral and central neuropathic pain. ...
Methyl fluoroacetate
MFA is a convulsant poison. It causes severe convulsions in poisoned victims. Death results from respiratory failure. For a ... Methyl fluoroacetate causes progressive depression of respiration and is a convulsant poison, in most animals. When applied to ... The difficulties of treatments are stressed as methyl fluoroacetate is both a powerful convulsant and a respiratory depressant ...
Mr. Bungle
Trevor Dunn joined Patton in Fantômas and Tomahawk as well as forming his own jazz band, Trevor Dunn's Trio Convulsant; he also ... "Trevor Dunn's Trio Convulsant Biography". Ipecac Recordings Official Site. Retrieved May 20, 2007. "The Tango Saloon Biography ...
Picrotoxin
... also acts as a convulsant. In larger doses, it has been found to induce clonic seizures or cardiac dysrhythmias, ... Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. It mainly ...
Pericine
It may also have convulsant effects. Pericine has been prepared in the laboratory by total synthesis. Conolidine Arens H, Borbe ...
Trevor Dunn
In 1998, Dunn formed his Trio-Convulsant. Their first release, Debutantes & Centipedes, features Dunn on bass, Adam Levy on ... "Ipecac Recordings - Trevor Dunn's Trio Convulsant". Ipecac.com. Retrieved July 7, 2011. "Biography". Trevordunn.net. Retrieved ... Secret Chiefs 3 and with his own avant-garde jazz/rock ensemble Trevor Dunn's Trio-Convulsant. He is also a member of the band ... 1950's Czech Contrabass used with Trevor Dunn's Trio-Convulsant, occasionally with Mr. Bungle and with King Buzzo 1991 Alembic ...
Bicyclic phosphate
They act as GABA receptor antagonists and have potent convulsant effects. Convulsant TBPS TBPO IPTBO Bellet, E. M.; Casida, J. ... BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA ...
Salla disease
Anti-convulsant medication may control seizure episodes. Physical therapists can assist an affected individual to build muscle ...
Nonsynaptic plasticity
These neurons become highly sensitized to convulsant agents. It has been shown that seizures early in life can predispose one ...
TBPS
... (tert-butylbicyclophosphorothionate) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... "Solubilization and anionic regulation of cerebral sedative and convulsant receptors labeled with [35S] tert- ...
Translocator protein
Sedative yet also convulsant and anxiogenic in mice. Peptides Anthralin - 16kDa polypeptide, binds to both TSPO receptor and ...
Isoflurothyl
Convulsant Flurothyl Sevoflurane Krasowski, MD (27 April 2000). "Differential modulatory actions of the volatile convulsant ... Isoflurothyl is a fluorinated ether related to the inhalational convulsant flurothyl. It is the structural isomer of flurothyl ...
BIDN
... is a GABA receptor antagonist and convulsant. Cloflubicyne TBPS EBOB IPTBO Rauh, James J; Holyoke, Caleb W; Kleier, Daniel ...
FG-7142
It has anorectic, anxiogenic and pro-convulsant effects. It also increases release of acetylcholine and noradrenaline, and ...
Frog
The chemicals involved may be irritants, hallucinogens, convulsants, nerve poisons or vasoconstrictors. Many predators of frogs ...
Cloflubicyne
BIDN EBOB Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: ... It's an irreversible GABA receptor antagonist with powerful convulsant effects. ...
Crimidine
... is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was ... permanently deactivating the enzyme Crimidine is a fast acting convulsant, with an LD50 of 5 mg/kg. Earliest symptoms can ...
IPTBO
Bowery, N.G.; Collins, J.F.; Hill, R.G.; Pearson, S. (April 1976). "GABA antagonism as a possible basis for the convulsant ... IPTBO is both a convulsant and a stimulant, essentially causing an overload of chemical signals in the brain and overexciting ... IPTBO (isopropylbicyclophosphate, also IPPO) is a bicyclic phosphate convulsant. It is an extremely potent GABA receptor ... "The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant ...
Pethidine
Norpethidine is toxic and has convulsant and hallucinogenic effects. The toxic effects mediated by the metabolites cannot be ...
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Mr Hewison had epilepsy and needed anti-convulsant drugs. He concealed his illness so that he could do offshore work with his ...
History of electroconvulsive therapy in the United Kingdom
Mowbray RM (1959) Historical aspects of electric convulsant therapy. Scottish Medical Journal 4: 373-378. Cerletti U (1956) ...
Debutantes & Centipedes
Trevor Dunn's Trio Convulsant accessed December 5, 2017 Schulte, Tom. Trevor Dunn's Trio-Convulsant: Debutantes & Centipedes - ... Trio-Convulsant blend free and mainstream jazz, sub culture grunge rock or at times heavy metal as the overabundance of ... Debutantes & Centipedes is an album by bassist Trevor Dunn's band trio-convulsant which was released in 1998 on the Dutch Buzz ...
Trimethylolpropane phosphite
... is very toxic and is a convulsant. LD50 is 1.1 mg per kg bodyweight (mice, i.p.). Ende, ...
Nocturnal epilepsy
To minimize epileptic seizures in these people, it is important to find an anti-convulsant medication that does not disrupt a ... The anti-convulsant medications that were tested to meet this criterion are: phenobarbital, phenytoin, carbamazepine, valproate ... Despite the effectiveness of anti-convulsants in people who suffer from nocturnal epilepsy, the drugs are shown to disrupt a ... Another study determined that anti-convulsant medications can minimize epilepsy not just in people who are awake, but also in ...
Convulsant - Wikipedia
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs ... Some convulsants such as pentetrazol and flurothyl were previously used in shock therapy in psychiatric medicine, as an ... Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. Convulsions ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ...
Trevor Dunn's Trio-Convulsant - Wikipedia
Anti-convulsant syndrome awareness | Otago Daily Times Online News
Foetal Anti-Convulsant Syndrome New Zealand executive officer Denise Astill said the damage caused by the anti-convulsant ... Anti-convulsant syndrome awareness. You are not permitted to download, save or email this image. Visit image gallery to ... Mrs Carlson-McLaren was quick to say that not all women on anti-convulsant drugs would have a child affected by FACS, but there ... The group believed all anti-convulsant medications carried a risk, but if a woman was on Epilim (sodium valproate) the risk of ...
Convulsants | definition of convulsants by Medical dictionary
... convulsants explanation free. What is convulsants? Meaning of convulsants medical term. What does convulsants mean? ... Looking for online definition of convulsants in the Medical Dictionary? ... convulsant. a drug which causes convulsions.. Patient discussion about convulsant. Q. my friend has convulsions what can i do ... convulsant. (redirected from convulsants). Also found in: Dictionary. con·vul·sant. (kon-vŭlsant), A substance that produces ...
Anti-convulsant pregabalin effective for patients after total knee replacement - Thaindian News
Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. - PubMed - NCBI
Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation
These studies show that loss of Kv4.2 channels is associated with enhanced susceptibility to convulsant stimulation, supporting ... Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation Epilepsia. 2009 Jul;50(7):1741-51. doi: ... In these studies, we evaluated young adult Kv4.2 knockout mice for spontaneous seizures and the response to convulsant ... Discussion: These studies show that loss of Kv4.2 channels is associated with enhanced susceptibility to convulsant stimulation ...
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Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures
We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the ... Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures Dis Model Mech. 2012 Nov ... We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the ... high-throughput in vivo indicator of the neural response to convulsant treatment and lends itself well to chemical screening ...
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Repetitive Convulsant-Induced Seizures Reduce the Number But Not Precision of Hippocampal Place Cells | Journal of Neuroscience
Repetitive Convulsant-Induced Seizures Reduce the Number But Not Precision of Hippocampal Place Cells. Hai Lin, Balázs Hangya, ... Flurothyl(bis-2,2,2-triflurothyl ether), a potent, rapidly acting CNS convulsant, induces seizure due to its antagonism to GABA ... Repetitive Convulsant-Induced Seizures Reduce the Number But Not Precision of Hippocampal Place Cells ... Repetitive one-per-day seizures induced in otherwise normal rats by the volatile convulsant flurothyl decrease the accuracy of ...
Convulsants Acting at the Inhibitory Glycine Receptor | Springer for Research & Development
1994) Convulsants Acting at the Inhibitory Glycine Receptor. In: Herken H., Hucho F. (eds) Selective Neurotoxicity. Springer ... Hill RG, Simmonds MA, Straughan DW (1976) Antagonism of γ-aminobutyric acid and glycine by convulsants in the cuneate nucleus ... Longo VG, Silvestrini B, Bovert D (1959) An investigation of convulsant properties of the 5-7-diphenyl-l-3-diazaadamantan-6-ol ... Barker JL, McBurney RN, Mathers DA (1983) Convulsant-induced depression of amino acid responses in cultured mouse spinal ...
Anti-convulsant drug significantly reduced major depression symptoms
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Anti-Convulsant Activity of Coleus amboinicus (lour.) | 123 Help Me
AMMONIUM ION CONTENT AND ELECTRICAL ACTIVITY OF THE BRAIN DURING THE PRECONVULSIVE AND CONVULSIVE PHASES INDUCED BY VARIOUS...
ION CONTENT AND ELECTRICAL ACTIVITY OF THE BRAIN DURING THE PRECONVULSIVE AND CONVULSIVE PHASES INDUCED BY VARIOUS CONVULSANTS ... ION CONTENT AND ELECTRICAL ACTIVITY OF THE BRAIN DURING THE PRECONVULSIVE AND CONVULSIVE PHASES INDUCED BY VARIOUS CONVULSANTS ... ION CONTENT AND ELECTRICAL ACTIVITY OF THE BRAIN DURING THE PRECONVULSIVE AND CONVULSIVE PHASES INDUCED BY VARIOUS CONVULSANTS ... ION CONTENT AND ELECTRICAL ACTIVITY OF THE BRAIN DURING THE PRECONVULSIVE AND CONVULSIVE PHASES INDUCED BY VARIOUS CONVULSANTS ...
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Under special conditions the convulsant barbiturate was shown to increase the mean convulsant dose of a timed intravenous ... The convulsant barbiturate enhanced the crossed-extensor reflex elicited by electrical stimulation of the contralateral sciatic ... The low to medium-voltage, medium to fast-frequency pattern observed in the EEG with the convulsant barbiturate was still ... However, prior abolition of the crossed-extensor reflex by pentobarbital was not antagonized by small doses of the convulsant ...
Pharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Fluoroquinolones in Rats | Antimicrobial Agents and...
The highest convulsant dose, observed for enoxacin (2,414 ± 301 μmol/kg), was about 2.5 higher on average than the lowest dose ... The main advantages of the approach used in this study, over those of other strategies, are that the convulsant effects of FQs ... One possible explanation is that GABAA is not solely responsible for the convulsant activities of FQs but that other mediators ... When applicable, the in vivo approach used in this study seems to be very valuable in assessing the convulsant activities of ...
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Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats. John Rossi III, Anne E. ... Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats. John Rossi, Anne E. Jung ... Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats. John Rossi, Anne E. Jung ... Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats ...
Most recent papers with the keyword anti convulsants | Read by QxMD
Our data revealed the anti-convulsant effects of lower doses of sumatriptan, and pro-convulsant effects of higher doses of ... Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in ... GR 127935, a selective 5-HT1B/D antagonist, could abolish the sumatriptan anti-convulsant effects, but it was ineffective ... However, all available anesthetic agents have anti-convulsant activity. We compared the effect of thiopental and propofol on ...
Anti-convulsant | definition of Anti-convulsant by Medical dictionary
Anti-convulsant explanation free. What is Anti-convulsant? Meaning of Anti-convulsant medical term. What does Anti-convulsant ... Looking for online definition of Anti-convulsant in the Medical Dictionary? ... redirected from Anti-convulsant). Also found in: Dictionary, Thesaurus, Encyclopedia.. Related to Anti-convulsant: ... The group leading the action, the Organisation for Anti-Convulsant Syndrome, is staging a meeting in Liverpool to seek out ...
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1. Hospital admission: the primary outcome will be the time to hospital admission during the scheduled randomised treatment period. Admission is a useful indicator of a severe relapse of illness because, since bed provision is now minimal, the clinical threshold for admission is high. Admission to hospital is a useful pragmatic outcome: the majority of patients and clinicians view admission as a negative event that an effective maintenance treatment would be expected to prevent. In certain sites, because some mental health services use intensive alternatives to hospital treatment, the primary outcome will need to be a comparable administrative event such as new attendance at a day patient facility or active home treatment. The appropriate primary outcome will be established with each site before the trial starts and, for the purposes of the trial, a proxy must be 7 days per week treatment at day hospital or 7 days per week home treatment or 24 hour admission to flats and hostel accommodation ...
Effects of anesthetic agents on seizure-induction with intra-cortical injection of convulsants. - Nuffield Department of...
We examined three commonly used injected anesthetic for their impact on seizures induced by three convulsant agents. METHODS: ... the occurrence of spreading depressions and the presence of movements in response to the convulsants. RESULTS: Fentanyl plus ... for seizure onset for fentanyl plus droperidol compared to paralyzed unanesthetised rats were seen for any of the convulsants ( ... plus droperidol has useful properties as an anesthetic agent in studies of seizure induction with different convulsants. ...
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Convulsants That Decrease Inhibition - Mental Health
Much of our understanding of the cellular basis of epilepsy comes from the application of convulsants to the brain, in whole ... Convulsants That Decrease Inhibition. Last Updated on Mon, 28 Oct 2019 , Mental Health ... In addition, substances active at modulatory sites on GABA receptors can also exert convulsant activity, such as inverse ... Penicillin, the first widely used convulsant, is a weak antagonist of the recep ...
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α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification | PNAS
α-Thujone Is a Convulsant.. The i.p. LD50 of α-thujone in mice is about 45 mg/kg, generally with 0% and 100% mortality at 30 ... Emphasis is placed on the hypothesis that the convulsant action is caused by modulating the GABA-gated chloride channel. ... The convulsant action led to multiple speculations on mechanisms, one of which was antagonism of the γ-aminobutyric acid (GABA ...
PentylenetetrazoleGabapentinPhenytoinGABAADrugsPharmacologyMedicationAnticonvulsantPicrotoxinRatsStimulationInverse agonistsPENTYLENETETRAZOLGABAVivoNeuronesPotentZebrafishFlurothylSeizures inducedSeizure inductionPotassium ChannelsConvulsionsVitroFACSDepressantDrugPentobarbitalDosesReduced the frequencyTopamaxDoseOrganisationActivityFrequencyDecreaseMechanisticBrainAntiResponseResults
Pentylenetetrazole3
- We found that exposure of 2-day-old zebrafish embryos to the convulsant agent pentylenetetrazole (PTZ) rapidly induces the expression of synaptic-activity-regulated genes in the CNS, and elicited vigorous episodes of calcium (Ca(2+)) flux in muscle cells as well as intense locomotor activity. (nih.gov)
- Under special conditions the convulsant barbiturate was shown to increase the mean convulsant dose of a timed intravenous infusion of pentylenetetrazole. (aspetjournals.org)
- Comparable amounts of pentobarbital were much more effective in increasing the mean convulsant dose of pentylenetetrazole. (aspetjournals.org)
Gabapentin2
- However, another drug which has recently shown promise is the anti-convulsant drug gabapentin. (thefreedictionary.com)
- Gabapentin is in a class of medications called anti-convulsants, which means that it was originally developed to treat seizures. (oncolink.org)
Phenytoin3
- The present studies showed that significant depression of in vitro lymphocyte responsiveness occurred with exposure to two anti‐convulsant agents (phenytoin and phenobarbital) and dexamethasone. (elsevier.com)
- Female gonadal sex steroids potentiate the anti-convulsant activity of phenytoin sodium. (bvsalud.org)
- The results suggest that there is an existing beneficial influence of the oral contraceptives both individually and in combination on the anti-convulsant activity of phenytoin , and this needs to be further probed. (bvsalud.org)
GABAA3
- Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. (wikipedia.org)
- Convulsants those actions previously unexplained (including penicillin and PTZ) may act as relatively selective antagonists of the action of GABA at GABAA receptors, the ma. (123helpme.com)
- Binding of the cage convulsant, [3H]TBOB, to sites linked to the GABAA receptor complex. (muscimol.xyz)
Drugs5
- Many other drugs may cause convulsions as a side effect at high doses (e.g. bupropion, tramadol, pethidine, dextropropoxyphene, clomipramine) but only drugs whose primary action is to cause convulsions are known as convulsants. (wikipedia.org)
- Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. (wikipedia.org)
- Ms Short, from Anglesey, said, 'I am very lucky to have a lovely son, but each day he suffers the damage caused by the anti-convulsant drugs. (thefreedictionary.com)
- This specific discovery is important as it may lead to more effective use of cilantro as an anti-convulsant, or to modifications of dodecenal to develop safer and more effective anticonvulsant drugs,' says Abbott. (news-medical.net)
- Anti-convulsant drugs may be given. (faqs.org)
Pharmacology1
- Crabbe, JC & Kosobud, A 1989, ' Genetic sensitivity to convulsants is determined by seizure sign rather than pharmacologic specificity ', Proceedings of the Western Pharmacology Society , vol. 32, pp. 161. (elsevier.com)
Medication3
- Information kits are being developed for doctors nationally to help inform women about the risk anti-convulsant medication may have for unborn children during pregnancy. (odt.co.nz)
- Foetal Anti-Convulsant Syndrome New Zealand executive officer Denise Astill said the damage caused by the anti-convulsant medication would become a bigger catastrophe than the Thalidomide babies. (odt.co.nz)
- As an organisation whose that supports those families whose children have been prenatally effected by anti-convulsant medication we have been continually shocked at the lack of awareness of adverse drug effects and their effects upon the general public. (alltrials.net)
Anticonvulsant4
- A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. (wikipedia.org)
- Fisher's exact test was performed to determine significance of other anticonvulsant and convulsant properties results. (thefreedictionary.com)
- Benzodiazepines are undoubtedly potent anti-convulsants on acute administration but their use in long-term treatment of epilepsy is limited by the development of tolerance to the anticonvulsant effects and by side-effects such as sedation and psychomotor slowing (38,39). (thefreedictionary.com)
- In mice, S-mTFD-MPPB acted as a convulsant, whereas R-mTFD-MPPB acted as an anticonvulsant. (elsevier.com)
Picrotoxin1
- METHODS AND RESULTS: By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the [gamma]-aminobutyric acid type A ([GABA. (thefreedictionary.com)
Rats1
- Repetitive one-per-day seizures induced in otherwise normal rats by the volatile convulsant flurothyl decrease the accuracy of locating a hidden goal without changing the mean location of goal selection. (jneurosci.org)
Stimulation4
- Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. (nih.gov)
- In these studies, we evaluated young adult Kv4.2 knockout mice for spontaneous seizures and the response to convulsant stimulation in the whole animal in vivo and in hippocampal slices in vitro. (nih.gov)
- These studies show that loss of Kv4.2 channels is associated with enhanced susceptibility to convulsant stimulation, supporting the concept that Kv4.2 deficiency may contribute to aberrant network excitability and regulate seizure threshold. (nih.gov)
- The convulsant barbiturate enhanced the crossed-extensor reflex elicited by electrical stimulation of the contralateral sciatic nerve while pentobarbital depressed this response. (aspetjournals.org)
Inverse agonists1
- In addition, substances active at modulatory sites on GABA receptors can also exert convulsant activity, such as inverse agonists of the benzodiazepine receptor. (euroformhealthcare.biz)
PENTYLENETETRAZOL1
- Here we further studied in vivo the sensitivity of the hippocampal CA1 neurons in response to CTZ in epileptogenesis in comparison with two other classic convulsants of kainic acid (KA) and pentylenetetrazol (PTZ). (naver.com)
GABA6
- Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. (thefreedictionary.com)
- Here, we present evidence that RDX binds at the convulsant site of the [gamma]-aminobutyric acid type A ([GABA. (thefreedictionary.com)
- The key concern is that, under these conditions, GABA binding experiments may not be relevant for predicting the convulsant activities of FQs administered alone. (asm.org)
- 1 [ 35 S]t-Butylbicyclophosphorothionate (TBPS) binding to the convulsant sites of the γ-aminobutyric acid (GABA(A)) receptor complex was measured in washed membranes prepared from rat forebrain. (elsevier.com)
- 4 The decrease in TBPS binding by butanedione pretreatment could not be prevented by GABA or by picrotoxinin, a ligand of the convulsant sites. (elsevier.com)
- Maksay, G 1993, ' Inactivation of the convulsant site of the GABA(A) receptor complex by arginine-specific reagents and its protection by the anion binding sites ', Molecular Neuropharmacology , vol. 3, no. 3, pp. 161-165. (elsevier.com)
Vivo3
- We conclude that this in situ hybridisation assay for fos transcription in the zebrafish embryonic CNS is a robust, high-throughput in vivo indicator of the neural response to convulsant treatment and lends itself well to chemical screening applications. (nih.gov)
- We have recently proposed an in vivo methodology that requires no mechanistic assumption for the assessment of FQs' convulsant activities ( 9 ). (asm.org)
- Much of our understanding of the cellular basis of epilepsy comes from the application of convulsants to the brain, in whole animal experiments and, more recently, to isolated slices of brain tissue maintained ex vivo. (euroformhealthcare.biz)
Neurones1
- Barker JL, McBurney RN, Mathers DA (1983) Convulsant-induced depression of amino acid responses in cultured mouse spinal neurones studied under voltage clamp. (springer.com)
Potent1
- Toxopyrimidine is a vitamin B 6 antagonist with potent convulsant effects. (wikipedia.org)
Zebrafish1
- At 7 days postfertilization (dpf), after having undergone completion of brain formation at 5 dpf, zebrafish exhibit behavioral, electro-graphic, and molecular changes to chemical convulsants that would be expected from a rodent seizure model. (thefreedictionary.com)
Flurothyl1
- Some convulsants such as pentetrazol and flurothyl were previously used in shock therapy in psychiatric medicine, as an alternative to electroconvulsive therapy. (wikipedia.org)
Seizures induced1
- We examined three commonly used injected anesthetic for their impact on seizures induced by three convulsant agents. (ox.ac.uk)
Seizure induction3
- A] receptor convulsant site is the primary mechanism of seizure induction by RDX and that reduction of GABAergic inhibitory transmission in the amygdala is involved in the generation of RDX-induced seizures. (thefreedictionary.com)
- Effects of anesthetic agents on seizure-induction with intra-cortical injection of convulsants. (ox.ac.uk)
- CONCLUSION: Fentanyl plus droperidol has useful properties as an anesthetic agent in studies of seizure induction with different convulsants. (ox.ac.uk)
Potassium Channels1
- PDF] Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. (semanticscholar.org)
Convulsions1
- The purpose: Studying of efficiency of the combined application of the citicoline possessing nootropic and anticonvulsive action and antiepileptic drug of diazepam on the acute generalized convulsions (AGC) caused by a convulsant pentylentetrazole (PTZ). (bireme.br)
Vitro1
- For the two classes of caprolactams, with respect to inhibition or enhancement of muscimol binding, there appeared to be a relationship between in vitro effects and their convulsant or depressant activity in mice. (muscimol.xyz)
FACS2
- Weston mother and Foetal Anti-Convulsant Syndrome New Zealand support group education assistant Tanya Carlson-McLaren said the kits, due for release in November, contained information pamphlets for educators, family members, and health professionals about foetal anti-convulsant syndrome (FACS). (odt.co.nz)
- Cute Georgie who travelled from her home in Leicester, has brain damage and a condition known as Foetal Anti-Convulsant Syndrome (FACS). (thefreedictionary.com)
Depressant4
- Depending upon the dose, the convulsant barbiturate has both stimulant and depressant properties. (aspetjournals.org)
- The depressant actions of the convulsant barbiturate appear to be real and not secondary to the stimulant effects. (aspetjournals.org)
- Simple observations of an intact animal given the convulsant barbiturate offer no clue to primary depressant effects. (aspetjournals.org)
- Differential modulation of gamma-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant or convulsant activity. (muscimol.xyz)
Drug1
- Valproic acid (VPA) is a widely used anti‑epileptic and anti‑convulsant drug. (readbyqxmd.com)
Pentobarbital3
- The central nervous system effects of a convulsant barbiturate, sodium 5-ethyl-5-(1,3-dimethylbutyl) barbiturate, were compared with the actions of pentobarbital in cats. (aspetjournals.org)
- In the remaining two preparations the convulsant barbiturate reduced the frequency of spindle bursts and prolonged the interval between bursts in a manner similar to that of pentobarbital. (aspetjournals.org)
- However, prior abolition of the crossed-extensor reflex by pentobarbital was not antagonized by small doses of the convulsant barbiturate. (aspetjournals.org)
Doses2
- The convulsant activity previously observed at high doses was also investigated. (thefreedictionary.com)
- Nantenine showed a dose-dependent convulsant activity at doses ranging from 75 to 105 mg/kg. (thefreedictionary.com)
Reduced the frequency1
- Readers have also reported that a daily regimen of anti-inflammatory or anti-convulsant medicines have reduced the frequency and severity of their headaches. (thefreedictionary.com)
Topamax1
- The nurse ultimately discovers that the original physician's order was for Topamax (an anti-convulsant agent) 200mg PO/PT twice daily, not Toprol-XL (an anti-hypertensive agent). (thefreedictionary.com)
Dose1
- It is a biological product containing multiple compounds with unclear, possible, anti- or pro-convulsant effects, delivered in varying amounts from dose to dose,' he adds. (freerepublic.com)
Organisation1
- The group leading the action, the Organisation for Anti-Convulsant Syndrome, is staging a meeting in Liverpool to seek out further potential victims on top of the nine families already registered. (thefreedictionary.com)
Activity3
- Anti-Convulsant Activity of Coleus amboinicus (lour. (123helpme.com)
- The presence of a methyl group on the piperazine moiety decreased the pharmacodynamic contribution to the convulsant activity by severalfold, and the ratios of concentrations of the FQs in cerebrospinal fluid (CSF) to concentrations of unbound FQs in plasma varied from about 5 to 75% as a function of lipophilicity. (asm.org)
- We recorded EEG activity, the latencies to seizure discharges, the occurrence of spreading depressions and the presence of movements in response to the convulsants. (ox.ac.uk)
Frequency2
- The low to medium-voltage, medium to fast-frequency pattern observed in the EEG with the convulsant barbiturate was still present in three of five mesencephalic preparations verified by autopsy to be complete transections. (aspetjournals.org)
- A meta-analysis of the four RCTs reported no evidence of an effect on the frequency of first seizure in patients receiving anti-convulsant prophylaxis. (canceraustralia.gov.au)
Decrease1
- A systematic review by Mikkelson et al (2010) assessed if prophylactic anti-convulsants decrease the risk of seizures in patients with metastatic brain tumours compared with no treatment. (canceraustralia.gov.au)
Mechanistic1
- To apply the same strategy to locate the convulsant sites requires the creation and mechanistic characterization of a suitable agent. (elsevier.com)
Brain2
- The Quality Standards Subcommittee of the American Academy of Neurology published a practice parameter on the use of prophylactic anti-convulsants in patients with primary and metastatic brain tumours (2000). (canceraustralia.gov.au)
- The practice parameter concluded that in 12 studies (four RCTs and eight cohort studies) examining the use of prophylactic anti-convulsants to prevent first seizures in patients with brain metastases, none have demonstrated efficacy. (canceraustralia.gov.au)
Anti6
- However, the action claims that adverse reactions to Vigabatrin, an anti-convulsant which was introduced in the late 1980s, have caused such severe eye problems that some patients have even been registered blind. (thefreedictionary.com)
- SNRIs, anti-convulsants). (cdc.gov)
- The review concluded that there is a lack of clear and robust benefit from the routine prophylactic use of anti-convulsants. (canceraustralia.gov.au)
- Artificial Sweeteners Act as Anti- Convulsants. (blogspot.com)
- Anti-convulsants, HIV protease inhibitors, methadone. (thebody.com)
- I asked my neuro about adding a anti convulsant. (healingwell.com)
Response1
- In addition to enhancing induced seizure behavior, p,p '-DDE also promotes a unique and readily observed head-shake behavior in response to the two chemical convulsants (Tiedeken and Ramsdell 2009). (thefreedictionary.com)
Results1
- Thus, the inhibitory sites are not enantioselective, and the convulsant action of S-mTFD-MPPB results from its negligible affinity for the enhancing, anaesthetic sites. (elsevier.com)